LOCUS 029_IIG_Bs27_007_SNP 3631657 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1e5-cvskbth VERSION urn.local...1e5-cvskbth KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3631547..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..399834) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399520..399539 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399521 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="upshifts" CDS 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" /label="yclG CDS" gene 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /label="yclG gene" promotor_-10 complement(399831..399849) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399844) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399865..399870) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401305 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" /label="yczF CDS" gene complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /label="yczF gene" promotor_-10 complement(401570..401581) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401572) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401596..401602) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 401617..401623 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 401637..401648 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401650 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="upshifts" CDS 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" /label="gerKA CDS" gene 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /label="gerKA gene" CDS 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" /label="gerKC CDS" gene 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /label="gerKC gene" CDS 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" /label="gerKB CDS" gene 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /label="gerKB gene" downshifts 405654 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" /label="downshifts" CDS complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" /label="yclH CDS" gene complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /label="yclH gene" CDS complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" /label="yclI CDS" gene complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /label="yclI gene" misc_feature 408101..408120 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408104 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" /label="yclJ CDS" gene 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /label="yclJ gene" CDS 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" /label="yclK CDS" gene 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /label="yclK gene" downshifts 410211 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" /label="downshifts" S_feature 410256..410360 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410350..410369 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410362 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(410394) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" /label="downshifts" CDS 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" /label="rapC CDS" gene 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /label="rapC gene" promotor_-35 411246..411251 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411264 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 411268..411286 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411408..411416 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411428..411446 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411440 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" /label="phrC CDS" gene 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /label="phrC gene" downshifts 411639 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(411707) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" /label="yczM CDS" gene complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /label="yczM gene" downshifts complement(411912) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" /label="yczN CDS" gene complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /label="yczN gene" promotor_-10 complement(412057..412076) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412068) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(412089..412098) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" /label="thrD CDS" gene complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /label="thrD gene" downshifts complement(412198) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(412242) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(413590..413609) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413606) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413624..413631) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413745..413749 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413765..413784 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413777 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 413808..413815 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413829..413848 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 413838..413938 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 413838 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" CDS 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" /label="pbtN CDS" gene 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /label="pbtN gene" CDS 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" /label="pbtO CDS" gene 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /label="pbtO gene" CDS 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" /label="pbtP CDS" gene 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /label="pbtP gene" CDS 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" /label="pbtQ CDS" gene 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /label="pbtQ gene" downshifts 417539 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" /label="ycnB CDS" gene complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /label="ycnB gene" downshifts complement(417624) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" /label="ycnC CDS" gene complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /label="ycnC gene" S_feature complement(419920..419986) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(419985..420004) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(419994) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(420019..420025) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" /label="nfrAB CDS" gene complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /label="nfrAB gene" downshifts complement(420096) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" /label="ycnE CDS" gene complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /label="ycnE gene" promotor_-35 421102..421109 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421123..421142 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421142 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(421180..421199) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421196) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421213..421220) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421241..421248 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421253 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 421259..421278 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" /label="yczG CDS" gene 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /label="yczG gene" downshifts 421582 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(421916..421927) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421922) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421941..421947) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423074..423093) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423075..423082 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423081) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 423096..423115 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423100 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(423104..423111) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 424326..424332 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424346..424364 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424354 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 424450..424457 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424472..424491 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424481 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 425913 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 425963..425969 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 425983..425994 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 425984 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 427016..427035 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427016 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 427104 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 427698 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(427752) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(430622..430641) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430637) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(430655..430662) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 430722..430741 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 430734 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 431089 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 431182..431189 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431203..431222 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431208 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 431218..431290 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 434289 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 434335..434338 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434354..434373 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434356 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 434631..434639 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434653..434672 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434663 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 435455 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 435528..435535 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435548..435567 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435561 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 436160..436884 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(436845..436864) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 436861..436867 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(436868) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436880..436899 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 436886 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 437282 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(437358) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(437512..437530) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437534) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(437545..437551) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437564..437571 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437585..437604 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437588 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 438361 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(438437) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 438467..438473 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438487..438506 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438493..438589 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438493 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 442652 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 442746..442846 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 442806 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 443932..443941 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443955..443974 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443965 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 444625 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(444637..445062) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(444682) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 444715..444721 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444735..444754 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444736 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 445058..445468 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(445371..445390) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445387) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 445444..445448 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445465..445484 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445470 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 447508..447608 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 448491 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 448584..448591 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448605..448624 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 448609..448696 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 448609 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 450768 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 450810..450816 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450830..450848 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450842 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 450853..450934 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 450896..450903 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450917..450936 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450936 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 452488 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(452557) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(453136..453154) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453150) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(453169..453175) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453211..453217 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453229 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 453232..453250 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 454636 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 454684..454691 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454705..454724 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454707 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 455307..455313 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455328..455346 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455341 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 455797..455805 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455816..455835 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 455835..456201 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 455835 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(455861..455961) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(455901) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 456158 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 456238..456247 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456260..456275 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456265 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 457088 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(457155) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(457469..457488) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457469..457487 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457475 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(457485) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 457563..457570 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457584..457603 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457588 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 458057..458060 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458069 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 458077..458096 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 460291 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 460357..460363 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460378..460396 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460379..460510 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460379 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 467507 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 467620..467627 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467642..467661 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 467649 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 467800 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 467845..467998 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 469814 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 470343..470349 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470364..470382 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470365 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(471233..472092) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472094..472205) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472105 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(472137) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(472165..472265) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472174..472179 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472196..472214 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472205) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 472206..472421 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472206 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(472272..472343) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472315) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(472626..472645) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472644) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(472657..472664) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(472733) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(474053..474072) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474065) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(474067..474144) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474085..474092) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474128..474147) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474144) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(474161..474170) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(474229) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(474295) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(475027..475045) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475044) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(475059..475065) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475077 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 475085..475104 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 475935 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476012..476018 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476032..476050 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476040 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(476077) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 476461 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(476495) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(476498..476501) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476523..476530 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476542..476561 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476549 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(476973..477266) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477211 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 477255 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(477311) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(478150..478168) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478171) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478182..478188) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 478525..478532 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478547..479334 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478547..478566 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478548 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(479278..479297) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479283) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(479311..479318) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 481613..481687 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 481654..481661 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481676..481693 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481689 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 482991 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(483045) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 483082..483099 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483084 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 484199..484442 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484399 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 486220..486239 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486225 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 486566 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 486611..486680 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 486646..486653 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486667..486686 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486681 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 487846 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(487907) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(488069..488237) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488229..488248) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488239) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488263..488270) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488378..488383 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488399..488417 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488403 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 488669..488678 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488691..488706 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488694 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(489250..489319) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489293) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 489306..489655 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 489636..489640 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489649..489663 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 489657..489814 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 489657 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(489661..489680) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489676) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489694..489701) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 490867 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 492355..492361 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492375..492386 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492385 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 492428..492447 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492429..492603 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492429 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 492571..492578 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492593..492612 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 492605..492672 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 492605 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 494201 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 494321..494380 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494321..494330 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494323 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 494342..494357 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 496301 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 496346..496673 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496355) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 496643..496648 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496661..496680 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496675..497276 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 496675 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(497206..497225) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497217) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 497645..497650 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 497666..497807 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 497666..497684 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 497666 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 498809 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 498869..498876 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498890..498909 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 498897 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 500037..500042 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500057..500075 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500063 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 500138..500141 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500157..500176 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500158 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(500650..501126) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(500693) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 500840 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 500894..500901 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500915..500934 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500923 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(501109..501127) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501126) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501128..501727) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501141..501148) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(501716..501734) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501727) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501729..502317) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(501748..501754) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(502315..502334) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502332) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(502348..502357) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 503587..503593 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 503608..503626 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 503614 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 505802 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 505860..505866 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505881..505900 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(505889,505891) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 505893 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 506320..506328 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506340..506359 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 506355 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(506588..509643) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 507191 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 507247..507248 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507264..507283 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507264 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 509457..509476 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509479..509695 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509479 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(509632..509651) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(509649) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509666..509674) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 510154..510160 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510175..510194 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510183..510270 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510183 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(510215) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 510887 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 510988..510989 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<510989..511295) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 511008 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(511040) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(511991..512010) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(512004) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(512025..512032) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 512104..512108 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 512125..512144 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 512129 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 512130..512574 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 512986..513055 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 513012 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 514687..514691 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 514708..514727 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 514717 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 517058..517617 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 518847..518851 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 518866..518885 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 518874 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(518921,518923) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 519114 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 520171..520178 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520192..520211 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 520203..520320 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 520203 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(520238) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(520419..521207) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 520424 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 520525 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 521678..522223 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(521721) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(521728..521747) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(521763..521770) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 522190 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(523580) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(523584..523603) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(525636..525641) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(525643..525644) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(525648) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 525717..525723 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 525731 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 525737..525756 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 527134 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 528569..528575 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528590..528609 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 528597 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 528608..528718 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 529194 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 529245..529252 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 529267..529286 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 529268 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 530038 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(530114) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 530127..530134 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530148 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530149..530168 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(531055..531074) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531062) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(531086..531091) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 532334..532340 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 532355..532374 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(532356..532375) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 532370 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(532380) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532390..532397) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 533965..533972 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 533983..534002 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 533997 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 534457..535711 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(534514) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(535082..535162) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(535509..535528) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(535526) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 535700..535719 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 535713 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 536506 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 536704 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(536781) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(537156..537220) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 537208..537215 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(537209..537228) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537222) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 537229..537248 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 537232 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(537243..537250) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 539326..539330 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 539344 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 539345..539364 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 540268 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 540401..540404 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 540411..540597 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 540411 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 540419..540438 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 542697..542705 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 542716..542734 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 542733 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 542798 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 543546 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(546859..546878) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 546867..546874 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546878) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 546889..546908 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546891 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546893..546899) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 547638 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(547690) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(548151..548170) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548175) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548184..548191) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 548484..548486 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548502..548521 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548518 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 550652 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(550685..550704) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550706) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(550718..550725) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 550766..550771 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 550784 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 550786..550804 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(551850..551868) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(551850) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(552952..553359) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 552969..552973 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 552983 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 552986..553005 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(552997) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(554263..554358) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(554338..554357) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(554358) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(554371..554378) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(556084..556103) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(556097) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(556119..556126) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(556186) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(557060..557152) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(557133..557152) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(557150) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(557168..557175) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 557341..557348 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 557363..557382 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 557369 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 557879..557885 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 557890 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 557899..557917 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 559097..559100 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559115..559134 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559122..559210 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 559122 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 559591 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 559714..559733 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 559716..559785 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 559716 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 560112 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(560188) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 560212..560218 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560233..560244 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 560244 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(560401..560562) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(560566..560931) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(560606) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 561146 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(561183..561202) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561200) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(561202..561285) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(561216..561225) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(561934..561945) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561948) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561960..561966) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(561964..562797) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 561979..561984 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561999..562010 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562004 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(563792..563811) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(563796) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563825..563834) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563989..563996 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 564012..564031 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 564020 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 564998..565159 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 565634..566326 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(565776) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(567471..567668) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 567485..567487 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567504..567522 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567508 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(567514) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 567634 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567660..567679) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567672) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567692..567699) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(567755) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(569182..569201) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(569197) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(569271,569273) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 569272..569305 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(569318) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569848..569867) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569867) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569883..569886) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569904..569911 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569926..569945 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569944 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(569956..570357) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(569956..570084) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(569956..570357) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(569956..570084) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 569974..570066 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 569974..570066 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 569976..569977 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(570288..570482) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(570288..570482) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(570515..570526) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(570523) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(570540..570546) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 570601..570608 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570622..570641 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 570624..570724 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 570626 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(570672) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 570684 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 570692..570699 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570713..570732 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 570728..570815 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 570728 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 570816..570892 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 570816..570892 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 570906..570979 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 570906..570979 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 571139..572693 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 571139..572693 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 572861..575788 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 572861..575788 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 575844..575960 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 575844..575960 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 575974..576050 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 575974..576050 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 576111..576187 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 576111..576187 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 576184 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 576288..576292 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 576308..576327 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576312 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 576368..577345 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 576368..577345 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 577360..577836 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 577360..577836 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 577817..578506 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 577817..578506 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 578516..578971 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 578516..578971 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 578964..580004 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 578964..580004 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 579968 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(580234..582162) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(580234..582162) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(580251) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 581914..581933 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 581924 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 581926..582115 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 582080..582087 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582101..582120 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 582117..582287 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 582117 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(582182..582201) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582194) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(582215..582222) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 582288..582800 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 582288..582800 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 582797..583444 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 582797..583444 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 583274..583374 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 583334 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 583466..583639 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 583466..583639 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 583646..584410 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 583646..584410 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 584390 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(584448..584639) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(584448..584639) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(584465) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(584636..585370) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(584636..585370) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 585028..585033 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585048..585066 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585050 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 585369..585370 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 585380..585394 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 585402 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(585407..585426) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 585424..585532 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(585427) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(585440..585445) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 585506..585512 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585526..585545 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 585534..585608 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 585534 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 585609..585893 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 585609..585893 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 585940..587574 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 585940..587574 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 587575..587667 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 587624 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(587662..587790) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(587662..587790) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 587669..>588895 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(587793..587951) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(587793..587951) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(587996..588124) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(587996..588124) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(588217..588426) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(588217..588426) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(588419..588724) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(588419..588724) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(588895,588902) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 588896..588901 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(589000..591489) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(589000..591489) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(589022) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(591503..591522) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(591529) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(591536..591543) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 591592..591593 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 591608..591690 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 591608 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 591609..591628 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 591691..592752 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 591691..592752 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 592826..594217 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 592826..594217 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 594244..594251 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 594265..594284 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 594270 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 594312..595274 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 594312..595274 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 595259 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 595399..595408 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 595415 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 595421..595436 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 595470..596153 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 595470..596153 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 596154..596218 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 596219..597244 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 596219..597244 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 597244..598008 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 597244..598008 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 598039..599010 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 598039..599010 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 599000 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 599044 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(599057..600082) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(599057..600082) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(600114..600133) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(600132) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(600147..600153) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 600342..600349 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 600362 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 600364..600666 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 600364..600383 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 600667..602088 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 600667..602088 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 602080 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(602136) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(602136..603176) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(602136..603176) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 602716..602725 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 602739..602758 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 602740..603275 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 602740 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(603177..603471) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 603276..603295 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 603277..603574 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 603277 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(603466..603480) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(603471) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 603573..603592 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 603576 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 603615..603986 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 603615..603986 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 603972 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 604052..605098 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 604052..605098 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 605072 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(605132..605290) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(605132..605290) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(605148) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(605347..605479) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(605390) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(605480..605689) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(605480..605689) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(605722..605741) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(605733) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(605772..606587) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(605772..606587) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 606414..606423 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 606436..606455 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 606436 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(606600..607589) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(606600..607589) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(607454..607472) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607462) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607488..607493) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(607611..607626) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607632) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607638..607647) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(607687..609228) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(607687..609228) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(607700) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(609259..609278) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(609273) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(609292..609301) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(609380..610789) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(609380..610789) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(609394) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(610827..611114) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(610827..611114) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(610830..610849) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(610844) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 611120..611127 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 611143..611162 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 611144 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 611187..612059 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 611187..612059 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 612024 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(612299) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 612353..612372 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 612363 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 612409..613371 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 612409..613371 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 613371..614567 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 613371..614567 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 614589..616802 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 614589..616802 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 616797..616804 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616819..616838 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 616835..616964 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 616835 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 616965..618506 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 616965..618506 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 618492 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 618613..618617 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 618633..618652 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 618643 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 618650..618752 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 618650..618752 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 618778 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 618887..620209 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 618887..620209 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 620187 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 620230 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 620259..620268 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 620279..620419 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 620279 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620281..620296 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620420..621223 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 620420..621223 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 621208 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 621291..621298 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621312..621331 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621318..621381 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 621318 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 621382..621549 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 621382..621549 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 621556 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 621600..621606 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621621..621639 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621624..621710 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 621624 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 621689..621696 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621710..621729 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 621712 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 621763..622317 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 621763..622317 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 622317..622514 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 622317..622514 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 622504 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 622560..622567 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 622582..622601 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 622584 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 622594..622696 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 622594..622696 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 622697..622836 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 622837..623325 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 622837..623325 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 623318..624460 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 623318..624460 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 624457..625752 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 624457..625752 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(624762..624781) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(624783) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(624796..624803) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 625826..626551 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 625826..626551 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 626544..626798 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 626544..626798 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 626795..627478 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 626795..627478 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 627462..629690 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 627462..629690 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(627710) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 629666..631096 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 629666..631096 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 631097..631197 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 631198..632238 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 631198..632238 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 632235..632822 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 632235..632822 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 632245..632259 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 632254 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(632521..632539) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632528) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632555..632560) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 632819..634357 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 632819..634357 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 634373..635641 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 634373..635641 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 635626 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(635681..636100) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(635681..636100) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(636170..636189) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(636179) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 636244..637518 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 636244..637518 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 637467 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(637533..637760) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(637533..637760) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(637544) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(637761..638181) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 637828..637833 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 637844 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 637847..637866 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 637889..639631 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 637889..639631 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(638166..638177) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(638181) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(638191..638197) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 638212 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 639605..639611 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 639623 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 639624..639643 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 639658..640653 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 639658..640653 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 640656..640970 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 640656..640970 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 640833 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 640975 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(641005..642582) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(641005..642582) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(641019) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(642596..642615) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(642615) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(642630..642636) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 642779..642782 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 642796 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 642799..642818 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 642847..643533 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 642847..643533 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 643595..645814 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 643595..645814 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 645838..647844 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 645838..647844 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 647860..649050 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 647860..649050 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(648055..648059) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(648059) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 649087..649106 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 649095..649211 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 649095 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(649159) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 649212..650222 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 649212..650222 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(649229..649329) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(649269) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 650205 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 650249..651053 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(650260..650958) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(650260..650958) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(650281) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(650978..650996) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650999) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(651012..651017) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(651065..652543) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(651065..652543) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(651079) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(651931) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(651934..651947) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(652544..652674) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(652665..652683) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(652674) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(652698..652704) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 652805..652808 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 652823..652956 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 652823 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 652825..652844 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 652957..653247 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 652957..653247 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 653263..654720 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 653263..654720 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 654734..656164 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 654734..656164 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 656145 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(656179..657048) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(656179..657048) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(656221) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 656838..656843 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 656859..656877 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 656871 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(657049..657123) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 657101..657108 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(657117..657136) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 657123 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 657124..657143 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657130) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(657151..657158) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 657180..660338 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 657180..660338 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 660325 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 660577..660580 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660595..660614 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660603 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 660661..661572 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 660661..661572 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 661573..661827 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 661828..663207 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 661828..663207 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 663208..663800 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(663220..664122) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(663220..664122) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 663757 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 663802..664102 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 664103..664438 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 664103..664438 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 664439..664512 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 664513..667152 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 664513..667152 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 667164..668963 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 667164..668963 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(667404..667419) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667419) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(667431..667440) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 668964..669075 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 669076..670224 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 669076..670224 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 670225..671414 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(670486..670791) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(670486..670791) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(670858..671064) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(670858..671064) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(671304..671759) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(671304..671759) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(671317) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(671779..673788) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(671779..673788) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(672146..672165) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(672153) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(672178..672183) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(673815..673834) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(673825) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 674000..675022 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 674000..675022 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 675122..675129 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 675143..675162 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 675144 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 675184..676314 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 675184..676314 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 676304..676477 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 676304..676477 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 676432 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 676478..676582 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 676549..676556 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 676571..676590 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 676584 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 676637..677356 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 676637..677356 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(676639) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 677214..677221 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 677235..677254 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 677245 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 677338 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 677425..677434 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 677448..677467 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 677451 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(677455..677473) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(677475) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(677489..677494) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 677490..677927 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 677490..677927 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(677497) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 677927 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 677987..677994 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 678010..678029 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 678015 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 678042..678626 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 678042..678626 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 678607 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 678705..679148 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 678705..679148 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 679145..680005 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 679145..680005 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 680067..680072 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 680088..680106 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 680088 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(680110..680124) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(680115) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(680132..680136) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 680132..680380 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 680132..680380 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 680364..680627 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 680364..680627 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 680642..681211 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 680642..681211 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 681212..681290 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 681263..681268 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 681283..681302 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 681292 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 681336..681878 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 681336..681878 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 681845 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 681901..682203 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 681901..682203 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 682246..682254 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 682265..682283 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682271 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 682318..682947 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 682318..682947 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 682944..684677 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 682944..684677 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 684677..685783 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 684677..685783 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 685737 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 685822..685825 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685840..685859 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685847 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 685887..687170 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 685887..687170 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 687167..688096 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 687167..688096 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 688100..688990 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 688100..688990 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 689006..690040 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 689006..690040 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 690063..692348 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 690063..692348 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 692362..693060 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 692362..693060 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 693053..693715 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 693053..693715 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 693712..694338 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 693712..694338 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 694459..696321 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 694459..696321 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 694499..694599 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 694559 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(695097) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(695098..695117) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(695130..695139) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 696367..698205 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 696367..698205 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 698363..699016 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 698363..699016 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 699024..701015 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 699024..701015 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 701059..703632 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 701059..703632 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(702381..702399) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(702394) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(702415..702420) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 703754..705262 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 703754..705262 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 705317..706273 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 705317..706273 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(705591) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(705617..705717) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(705657) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 706287..707174 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 706287..707174 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 706921..706926 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706942..706960 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706945 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 707183..708523 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 707183..708523 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(707617..709308) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 708524..708605 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 708606..709301 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 708606..709301 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 709299 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(709338..709664) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(709338..709664) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(709353) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 709651 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(709687..709706) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(709705) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(709721..709728) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(709768..710130) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(709768..710130) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(710153..710172) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(710167) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(710185..710191) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(710201..710761) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(710233) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(710744..710763) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(710761) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(710777..710786) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 710849..710856 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 710865 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 710869..710888 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 710914..711495 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 710914..711495 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 711489..711785 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 711489..711785 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 711777 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 711856..711863 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711877..711896 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711885 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 711940..712107 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 711940..712107 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 712149..712156 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 712172..712191 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 712173 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 712217..712861 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 712217..712861 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 712797 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 712841 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 712861..713853 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 712861..713853 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 713787 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 713831 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(713877..714380) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(713877..714380) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(714405..714424) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(714413) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(714438..714445) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 714543..715652 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 714543..715652 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 715635 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(715687..716757) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(715687..716757) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(715711) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(716788..716807) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(716814) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(716822..716829) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 716837..716843 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 716858..716876 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 716867 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 716907..720092 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 716907..720092 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 720079 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 720142..720147 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720163..720181 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 720184 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 720212..720215 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720232..720251 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 720233..720538 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 720233 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 720539..722458 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 720539..722458 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 722457 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 722546..722555 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 722565..722693 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 722565 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 722569..722588 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(722619) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 722694..723458 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 722694..723458 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 723465..724433 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 723465..724433 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 724457..725368 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 724457..725368 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 725246..725255 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 725268..725287 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 725271 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 725397..726575 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 725397..726575 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 726116..726122 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 726137..726156 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 726151 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 726576..727511 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 726576..727511 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 727383 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 727493 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(727534) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(727542..728771) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(727542..728771) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(728800..728819) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(728818) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(728835..728842) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(728882..729589) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(728882..729589) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(728911) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(729612..729631) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(729635) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(729681..731066) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(729681..731066) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(729703) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(731115..731134) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(731132) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(731149..731156) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 731234..731241 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 731249 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 731255..731273 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 731316..732773 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 731316..732773 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(732109..732128) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(732123) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(732141..732150) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 732787..733647 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 732787..733647 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 733631 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 733715..733722 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 733736..733755 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 733741 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 733782..735671 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 733782..735671 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 735655 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 735735..735754 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 735743 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 735794..736240 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 735794..736240 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(735796) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(735880..735883) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735885) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(735901..735902) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 736227 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 736303..736310 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736324..736343 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 736336 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 736365..736787 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 736365..736787 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 736623 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 736853..738043 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 736853..738043 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(738107) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 738334..738489 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 738334..738489 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(738609..740165) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(738609..740165) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(738633) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 739995..740001 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740016..740027 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740033 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(740215..740234) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(740219) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(740250..740254) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 740275..740278 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740294..740313 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740297 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 740338..741468 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 740338..741468 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 741451 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 741536..741982 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 741536..741982 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(742035..743054) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(742035..743054) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(742045) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(743075..743094) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(743079) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(743081..743535) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(743107..743114) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 743173..743180 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 743194..743213 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 743201..744298 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 743201 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(743536..744756) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(743536..744756) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(744793..744812) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(744800) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(744828..744835) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 744854..744861 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 744873..745048 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 744873 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 744876..744895 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 745005 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 745092..746555 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 745092..746555 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(745457..747127) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 746556..747049 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 747037..747042 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 747051..750316 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 747051 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 747058..747076 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(747128..747928) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(747128..747928) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(747941..748942) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(747941..748942) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(748528..748547) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(748540) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(748562..748569) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(748939..749940) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(748939..749940) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(750010..750029) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(750012..750959) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(750012..750959) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(750031) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(750031) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 750286..750291 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750307..750325 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 750318..750943 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 750318 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 750939..750958 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 750945..751476 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 750945 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(751001..751020) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(751008) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(751034..751041) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(751068..751436) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(751068..751436) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(751437..751549) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(751538..751557) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(751549) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(751569..751576) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 751617..751623 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751637..751655 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751637 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 751680..752027 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 751680..752027 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(751681) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 752023 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 752068..752148 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 752149..752168 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 752150 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 752218..753480 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 752218..753480 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 753475 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 753533..753536 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753551..753570 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753559 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 753607..755043 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 753607..755043 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 755035 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 755134..755153 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 755145 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 755170..756798 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 755170..756798 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 756770..757450 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 756770..757450 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 757453..758412 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 757453..758412 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 758381 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 758504..758511 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 758524..758543 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 758535..758607 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 758535 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 758608..759909 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 758608..759909 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 759906..759912 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 759926..759937 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 759927 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 759965..760759 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 759965..760759 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 760735 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 760814..760817 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 760832..760851 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 760845 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 760878..761969 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 760878..761969 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(761960..762235) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(761960..762235) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 761970..762301 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(762249..762268) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(762263) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(762283..762290) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 762302..762967 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 762302..762967 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(763008..763145) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(763008..763145) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(763022) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(763146..763276) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(763262..763280) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 763272..763277 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(763276) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 763287..764351 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 763288 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 763293..763311 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(763296..763301) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(763302..763457) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(763302..763457) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(763458..763563) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(763564..763878) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(763564..763878) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(763879..763959) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(763960..764709) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(763960..764709) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(764738..764757) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(764751) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(764753..765889) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(764769..764777) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 764820..764821 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764841..764860 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 764844 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 764881..766239 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 764881..766239 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(765875..765894) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765889) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765908..765917) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 766125 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 766235 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(766272..768221) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(766272..768221) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(766289) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 767331..767337 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 767353..767371 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 767357..768321 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 767357 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768222..768296) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(768273..768292) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768296) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768298..768820) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(768308..768312) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 768322..768459 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 768322..768459 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 768437 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 768438..768457 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 768478..768870 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 768478..768870 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(768818..768836) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768833) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(768852..768857) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768939..768945 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768960..768978 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 768960 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 768995..770410 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 768995..770410 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(768996) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(769022..769122) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(769062) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(770407..771483) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(770407..771483) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 770411..773777 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(771507..771707) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(771507..771707) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(771723..772877) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(771723..772877) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(772858..774399) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(772858..774399) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(774449..774460) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(774452) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(774474..774480) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 774509..774516 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 774531..774550 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 774538 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(774584) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 774592..776004 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 774592..776004 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(774610..774710) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(774650) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 776075..777760 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 776075..777760 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(776381..776396) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776388) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776409..776418) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 777733..777737 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777753..777772 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 777756 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 777781..778497 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 777781..778497 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 778490 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 778572..778575 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778591..778610 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778600 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 778637..779302 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 778637..779302 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 779283 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(779339..783727) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(779339..783727) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(779358) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(783760..783779) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(783777) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(783794..783797) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 783904..783910 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783924..783942 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 783927 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 783970..784488 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 783970..784488 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 784474 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(784518) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 784519..786169 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(784528..785718) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(784528..785718) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(785719..785810) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(785811..786026) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(785811..786026) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(785870) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(786058..786077) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786072) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(786092..786093) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 786139..786146 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786161..786180 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786171 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 786229..786699 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 786229..786699 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 786717..787037 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 786717..787037 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 787061..787888 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 787061..787888 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 787867..787873 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 787888..787899 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 787906..788062 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 787906 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(787938) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 788037 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(788087..789262) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(788087..789262) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(788092) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 788699..788705 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 788721..788739 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 788725..789378 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 788725 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(789287..789306) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(789302) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(789320..789327) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 789368..789373 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 789380 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 789388..789406 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 789430..790485 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 789430..790485 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 790499..790505 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790520..790531 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790524 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 790556..791350 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 790556..791350 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 791338 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(791389..792231) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(791389..792231) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(791391) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(792232..793353) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(792232..793353) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(793394..793413) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793412) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(793429..793433) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 793441..793448 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 793462..793481 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 793472 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 793498..793683 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 793498..793683 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 793662 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 793726..793732 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 793738 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 793747..793758 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 793784..794575 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 793784..794575 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 794573 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(794613..795473) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(794613..795473) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(794627) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(795493..795512) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(795507) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(795528..795531) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(795572..796531) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(795572..796531) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(795595) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(796542..796561) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(796545) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(796577..796580) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 796592..796596 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796610..796629 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 796619 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 796650..797513 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 796650..797513 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 797514..797626 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 797627..799027 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 797627..799027 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 799039 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 799333..799340 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799356..799375 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799362 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 799369..799652 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 799653..799919 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 799653..799919 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(799867..799886) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(799885) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(799901..799904) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 799920..800401 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 800372..800375 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 800392..800411 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 800403..800650 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 800403 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 800651..801628 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 800651..801628 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 801629..801721 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 801678 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 801762..801768 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 801780..801799 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 801789 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 801824..802276 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 801824..802276 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 802306..802995 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 802306..802995 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 803000 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 803172..803190 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 803179 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 803227..804228 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 803227..804228 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 804232..805260 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 804232..805260 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 805274..806470 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 805274..806470 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(805275) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 806491..807867 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 806491..807867 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 807861 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 807914..807921 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 807934..807953 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 807942 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 807983..809800 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 807983..809800 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 809801..809807 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 809819 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 809822..809833 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 809854..810033 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 809854..810033 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 810017 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(810069..810398) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(810069..810398) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(810083) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(810448..810906) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(810448..810906) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(810907..810999) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(811000..811557) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(811000..811557) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 811423..811428 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 811436 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 811443..811461 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 811447..812034 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(811589..812356) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(811589..812356) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(812368..813591) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(812368..813591) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(813597..813911) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(813597..813911) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(813959..813978) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(813972) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(813993..813996) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 814203..814222 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 814206 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 814247..815596 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 814247..815596 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 815625..815644 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 815627 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 815661..816425 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 815661..816425 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(815805..815819) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(815835..815841) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(815835) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 816440..818023 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 816440..818023 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 818003 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 818052..818059 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818074..818093 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818082 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 818129..819850 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 818129..819850 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 819844..821658 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 819844..821658 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 821633 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 821740..821747 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821761..821780 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821765 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 821813..822217 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 821813..822217 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 822235..823092 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 822235..823092 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 823079 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 823186..824130 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 823186..824130 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(823997) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(824045..824145) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(824085) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 824305..825753 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 824305..825753 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 825780..826721 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 825780..826721 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 826731..827912 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 826731..827912 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 827902 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 827972..827978 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827993..828012 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 828011 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 828036..829238 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 828036..829238 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 829235..829897 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 829235..829897 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 829905 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 830041..830976 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 830041..830976 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 830989..832179 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 830989..832179 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 832193..833350 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 832193..833350 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 832304..832309 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832324..832342 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 832325 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(833348..833422) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(833391) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(833423..833971) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(833423..833971) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(833972..834051) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(834040..834059) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(834051) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(834073..834078) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 834174..834177 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 834193..834212 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 834200 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 834244..834876 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 834244..834876 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 834855 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 834991..834996 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835010..835029 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835020 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 835065..836153 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 835065..836153 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(835555..835943) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(835943) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(835945..835964) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(835977..835985) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(836189..836806) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(836189..836806) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(836207) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(836772..838025) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(836772..838025) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(836833..836852) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(836845) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(836866..836873) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(838059..838078) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(838077) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(838093..838100) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 838104..838123 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 838109 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 838149..838685 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 838149..838685 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(838682..840238) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(838682..840238) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(840260..840278) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840277) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840294..840297) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(840349..840831) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(840349..840831) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(840365) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(840856..840875) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840872) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840890..840896) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 840917..840924 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840938..840957 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840946 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 841003..843573 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 841003..843573 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 843544 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(843591..844568) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(843591..844568) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(843602) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 844583..844590 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(844595..844614) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 844605..844624 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 844607..844698 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 844607 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(844612) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(844629..844636) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 844699..845700 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 844699..845700 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 845697..846728 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 845697..846728 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 846709 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 846779..846781 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846797..846816 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846800 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 846843..847724 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 846843..847724 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 847735..847742 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 847758..847777 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 847767 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 847812..848396 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 847812..848396 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 848383 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(848435..848626) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(848435..848626) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(848453) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(848658) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(848661..848672) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(848687..848693) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(848693..848803) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(848693..848803) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(848832..848843) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(848834) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(848858..848864) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(848858..849769) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(848858..849769) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 849655..849658 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 849675..849694 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 849685..849857 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 849685 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(849791..849809) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(849805) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(849823..849829) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 849858..850652 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 849858..850652 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 850654..850968 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 850654..850968 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(850876..851144) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 850958 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 851042..851047 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 851063..851082 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 851068 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 851111..852304 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 851111..852304 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 852305..852539 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(852337..852489) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(852337..852489) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(852354) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 852518..852525 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 852539..852558 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 852541..852613 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 852541 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(852548..852559) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(852558) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(852574..852580) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 852614..852883 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 852614..852883 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 852872 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 852961..852967 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 852982 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 852983..853001 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 853028..853546 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 853028..853546 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 853547..853614 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 853582..853591 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 853603..853618 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 853616 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 853631..853963 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 853631..853963 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 853950..854810 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 853950..854810 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 854808 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 854868..854874 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854888..854899 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 854896..854960 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 854896 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(854918..854937) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(854927) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 854943..854949 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(854951..854952) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 854962..855042 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 854962 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 854964..854982 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 855043..856032 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 855043..856032 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(855192) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(855197..855201) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(855218..855222) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 856033..856103 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 856104..858689 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 856104..858689 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 858658 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(858682..859665) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(858682..859665) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(858716) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 859139..859148 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859161..859180 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859165 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(859666..859813) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 859770..859774 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859790..859809 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859797 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 859803..859880 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(859811..859830) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859813) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859845..859852) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 859881..860990 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 859881..860990 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 860827..860831 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 860847..860866 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 860859 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 860991..861303 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(860998..861222) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(860998..861222) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(861252..861263) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(861254) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(861277..861283) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 861304..862056 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 861304..862056 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 862073..862079 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862094..862105 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 862095 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(862102..862116) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(862123) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(862125..862129) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 862125..862379 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 862125..862379 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 862377 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(862402) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 862468..862812 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 862468..862812 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 862475..862483 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862494..862512 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 862496 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 862795 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 862851..862858 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862872..862891 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 862881..862955 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 862881 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 862956..863486 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 862956..863486 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 863477 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 863574..865316 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 863574..865316 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 865303 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(865393..866454) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(865393..866454) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(865404) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(866455..866545) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(866543..866562) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866552) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866577..866584) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(866674..867963) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(866674..867963) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(866677) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(867991..868010) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(868010) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(868012..868723) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(868022..868027) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 868056..868063 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868077..868096 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868077 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 868116..868589 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 868116..868589 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 868626..868633 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868648..868667 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868654 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 868712..869149 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 868712..869149 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 869131 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(869184..869537) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(869184..869537) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 869197 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(869207) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 869533..869537 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 869545..869559 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(869549..869568) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 869549..869640 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 869549 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(869559) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 869617..869620 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 869635..869654 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 869642..869744 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 869642 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 869745..870629 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 869745..870629 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 870612..870619 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 870633..870652 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 870648..870920 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 870648 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(870681) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 870921..872475 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 870921..872475 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 872643..875570 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 872643..875570 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 875571..875656 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 875632..875639 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875653..875672 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875658 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 875682..875797 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 875682..875797 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 875807..875881 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 875807..875881 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 875887..875978 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 875887..875978 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 875974 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 876013..876084 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 876013..876084 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 876094..876169 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 876094..876169 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 876179..876255 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 876179..876255 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 876267..876343 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 876267..876343 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 876356..876431 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 876356..876431 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 876437..876509 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 876437..876509 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 876532..876616 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 876532..876616 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 876622..876695 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 876622..876695 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 876720..876795 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 876720..876795 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 876805..876876 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 876805..876876 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 876926..877000 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 876926..877000 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 877006..877076 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 877006..877076 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 877084..877172 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 877084..877172 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 877173..877249 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 877206 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 877251..877419 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 877376..877383 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 877382 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 877397..877416 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877421 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 877438..877519 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 877438..877519 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(877455..877472) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(877458) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(877493..877498) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(877528) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(877598..878374) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(877598..878374) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(877612) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(878401..878416) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(878423) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(878429..878438) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 878458..878464 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 878479..878490 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 878482 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 878516..878719 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 878516..878719 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 878702 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(878778) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(878804..879076) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(878804..879076) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(879035..879053) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(879042) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 879057..879064 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(879070..879075) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879077..879096 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 879085 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 879118..879810 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 879118..879810 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 879839..879843 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(879842..879861) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(879854) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 879857..879876 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(879876..879883) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 879880..879987 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 879880..879987 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 879887 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 880018 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 880120..881892 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 880120..881892 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 881868 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 881913..882838 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(881930..883285) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(881930..883285) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(883313..883332) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(883330) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(883346..883355) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 883403..883409 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 883424..883443 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 883452 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 883536..883733 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 883536..883733 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(883760..885211) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(883760..885211) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(883770) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 885188..885194 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885209..885228 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885212 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(885229..885248) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 885234..885563 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(885248) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(885262..885269) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(885307..885325) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(885332) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 885520 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 885619..886386 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 885619..886386 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 886404..887402 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 886404..887402 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 887399..888229 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 887399..888229 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 888252..889382 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 888252..889382 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 889409..889428 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 889415 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 889486..890022 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 889486..890022 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 890023..890093 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 890063..890070 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890084..890103 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890095 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 890134..890403 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 890134..890403 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 890206..890210 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890233..890249 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890249 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 890390 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(890421..890894) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(890421..890894) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(890457) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(890896..891096) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(890896..891096) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(891125..891144) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891139) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891157..891164) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891220..891225 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891239..891258 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891239 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 891290..891363 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 891290..891363 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 891364..891546 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(891454..892077) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(891454..892077) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(891469) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 891503 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 891548..892159 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(892101..892120) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(892122) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(892134..892141) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 892160..893320 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 892160..893320 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 893329 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 893346..893358 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 893351 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 893387..894322 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 893387..894322 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(893405) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 894306..894309 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 894324 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 894325..894344 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 894360..894842 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 894360..894842 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 894825 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 894892..895608 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 894892..895608 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 894912..894919 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 894934..894953 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 894935 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 895599..896312 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 895599..896312 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 896324..897031 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 896324..897031 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 896915 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 896959 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 897025 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(897058..897233) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(897101) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(897225..897244) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897233) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(897259..897266) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 897298..897303 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 897319..897337 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 897319 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 897381..899276 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 897381..899276 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 897823..897923 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 897883 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 897949 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 899269 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 899333..899338 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899354..899372 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 899357..899455 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 899357 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 899456..900634 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 899456..900634 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 899654..899657 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899672..899691 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 899676 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(899917) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 900613 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 900721..900728 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 900743..900762 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 900743 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 900794..901258 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 900794..901258 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 901083..901089 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901104..901122 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901117 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 901267..901273 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901287..901298 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901293 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 901294..901959 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 901294..901959 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 902000..903598 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 902000..903598 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 903621..904151 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 903621..904151 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 904164..904538 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 904164..904538 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 904527 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 904538..904693 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 904538..904693 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 904628..904634 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904649..904668 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 904659 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 904698..905459 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 904698..905459 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(905011..905029) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(905025) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(905045..905050) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 905462..905827 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 905462..905827 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 905829..906527 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 905829..906527 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 906544..907461 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 906544..907461 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 907454..908395 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 907454..908395 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 908377 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(908487..908690) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(908487..908690) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(908501) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(908691..908818) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 908778..908789 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 908795 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(908807..908826) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908818) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(908820..909958) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(908840..908845) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 908985..908992 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 909007..909025 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 909014 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 909015..909125 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 909126..909956 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 909126..909956 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 909915 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(909959..911038) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(909959..911038) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(911048..911067) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(911069) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(911083..911087) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 911145..911152 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 911166..911185 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 911172 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 911211..912602 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 911211..912602 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(912238..912641) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 912581 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(912642..913097) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(912642..913097) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(913112..913130) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913140) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(913145..913151) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 913189..913195 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913209..913220 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913213 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 913247..913816 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 913247..913816 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 913443..913449 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 913460 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 913463..913474 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 913791 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 913859..913868 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913882..913901 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913892 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 913937..914905 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 913937..914905 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 914781 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(914837..915490) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(914837..915490) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(914854) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(915521..915532) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(915523) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(915547..915553) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 915562..915570 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 915573..919226 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 915573..919226 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 915581..915599 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915596 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 919223..919819 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 919223..919819 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 919798 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(919849..920757) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(919849..920757) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 920813..920821 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(920814..920825) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(920820) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(920822..921308) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 920832 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 920835..920854 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(920839..920845) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 920868..921263 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 920868..921263 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(921294..921313) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(921308) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 921348..921354 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 921363 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 921368..921379 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(921378..921392) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(921392) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(921400..921404) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 921400..921822 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 921400..921822 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(921726..921826) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(921766) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 921800 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(921832) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 921872..921879 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 921893..921912 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 921901 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 921949..922611 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 921949..922611 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 922627..924168 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 922627..924168 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 924151 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 924252..924443 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 924252..924443 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 924474..924481 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 924496..924515 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 924507..924588 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 924507 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 924589..925941 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 924589..925941 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 925969..926547 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 925969..926547 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 926542..926549 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926564..926583 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926575 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 926590 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 926635..926725 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 926726..927550 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 926726..927550 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 927569..929059 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 927569..929059 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 928370..928376 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 928391..928410 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 928401 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 929060..929148 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 929105 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 929111..929211 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 929171 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 929200..930867 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 929200..930867 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 930629..930634 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 930649..930667 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 930658 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 930712..930718 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930733 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930734..930752 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 930835 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 930880..930953 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 930935..930942 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930955 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930956..930975 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 930999..932744 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 930999..932744 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 932733 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 932778..932847 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 932849..932868 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 932849 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 932893..934032 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 932893..934032 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 934029..934673 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 934029..934673 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 934670..935194 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 934670..935194 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 935159 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(935209..935451) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(935209..935451) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(935230) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(935487..935498) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(935498) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(935512..935519) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 935586..935592 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 935606..935617 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 935616 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 935652..935975 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 935652..935975 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 935976..937842 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(936017..937483) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(936017..937483) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(936029) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(936116) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(937523..937541) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937535) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(937555..937562) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(937636..938076) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(937636..938076) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(937666) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 938064..938070 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938084..938095 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 938086..938196 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 938086 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(938098..938117) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938114) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938129..938135) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 938155 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(938183..939841) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(938183..939841) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(938188) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(939732..939750) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(939752) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(939764..939770) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 939813..939818 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 939834..939852 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 939847 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 939872..941278 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 939872..941278 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 941258 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(941308..942693) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(941308..942693) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(941334) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(942720) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(942722..944253) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(942730..942741) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 942849..942856 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 942869..942888 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 942875..943162 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 942875 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 943125..943128 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 943143..943162 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943164 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 943223..944227 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 943223..944227 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 944089 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 944219 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(944253) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(944260..944275) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 944265 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(944287..944296) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(944298..945173) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(944298..945173) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 945226..945227 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(945239..945258) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 945244..945263 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(945245) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 945254 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(945273..945278) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 945282..946382 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 945282..946382 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 946393..946399 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 946414..946432 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 946419 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 946456..947325 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 946456..947325 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 947333 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 947410..947413 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 947425 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 947428..947447 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 947473..947492 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 947478..947574 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 947478 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 947575..948972 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 947575..948972 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 948952 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 949033..949037 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 949053..949072 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 949060 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 949090..950445 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 949090..950445 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 950426 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(950480..951889) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(950480..951889) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 951938..951941 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951956..951975 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951958 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(951960..951979) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951972) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951995..951999) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 951999..952427 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 951999..952427 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 952406 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(952458..952748) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(952458..952748) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(952482) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(952736..953812) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(952736..953812) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(953802..954293) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(953802..954293) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(954294..954396) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(954385..954404) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954396) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(954418..954421) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 954434..954440 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 954451 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 954455..954473 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(954484) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 954490..955485 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 954490..955485 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 955464 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 955547..955550 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 955565..955584 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 955570 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 955620..956219 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 955620..956219 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 956234 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 956279..958233 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(956288..957622) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(956288..957622) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(956307) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(957683..958114) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(957683..958114) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(958126..958145) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(958136) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(958160..958166) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(958162..958262) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 958197..958204 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(958202) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 958218..958237 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 958235 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 958271..959452 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 958271..959452 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 959437 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 959482..959620 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 959616..959635 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 959622..959778 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 959622 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 959779..961164 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 959779..961164 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 961054 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 961140 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(961178..961534) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(961178..961534) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(961531..961926) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(961531..961926) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(961913..962644) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(961913..962644) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(962669..962688) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(962690) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 962737..962745 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 962754 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 962759..962774 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 962768..962841 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 962828..962829 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 962843 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 962845..962864 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 962878..962985 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 962878..962985 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 962986..963039 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 963010 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 963090..963109 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 963096 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 963134..964249 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 963134..964249 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 964229 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 964286..964305 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 964286 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 964319..965062 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 964319..965062 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 965034 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(965086..965934) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(965086..965934) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(965110) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 965930..965935 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(965935..966034) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 965951..965969 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965953 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 965958..966153 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(966023..966042) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(966037) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(966057..966060) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 966152..966171 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 966155..966218 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 966155 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 966219..967067 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 966219..967067 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 967058 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(967110..968471) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(967110..968471) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(967134) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(968472..968542) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(968515..968534) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(968542) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(968598..969098) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(968598..969098) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(968630) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(969120..969138) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(969140) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(969153..969159) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 969177..969184 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 969192..969261 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 969193 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 969199..969218 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 969262..969423 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 969262..969423 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 969353 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 969424..969542 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 969543..971300 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 969543..971300 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 971297..973318 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 971297..973318 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 973306 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(973367..973987) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(973367..973987) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(973382) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 973972..974072 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(974001..974020) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974016) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(974026..974151) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(974026..974151) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 974032 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974035..974038) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(974165..974184) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974174) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974198..974207) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 974230 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(974256..974459) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(974256..974459) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(974261) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(974460..974570) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 974500..974600 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 974560 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(974576) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(974580..974591) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(974606..974612) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(974668..974886) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(974668..974886) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(974702) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(974927..974946) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974944) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974960..974967) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(975036..976397) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(975036..976397) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(975054) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(975098) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(976387..977478) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(976387..977478) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(976802..976816) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(976814) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(976830..976838) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(977479..977584) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(977568..977586) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977588) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977602..977607) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 977650..977657 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977672..977691 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977683 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 977745..978878 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 977745..978878 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 978879..978970 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 978971..979324 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 978971..979324 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 979312 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(979368..980441) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(979368..980441) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(979475) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(980463..980482) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(980475) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(980496..980503) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 980578..980585 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 980598 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 980600..980619 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 980609..980762 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 980719 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 980764..980847 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 980804 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 980860..980865 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980881..980899 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980890 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 980927..981793 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 980927..981793 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 981775 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 981838..981841 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 981856..981875 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 981864 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 981905..983410 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 981905..983410 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 983380 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(983428..984645) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(983428..984645) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(983434) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(984652..985149) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(984652..985149) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(985213..985551) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(985213..985551) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(985563..985582) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(985587) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(985596..985603) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 985623..985630 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 985645..985664 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 985655 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 985716..986483 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 985716..986483 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 986484 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(986504..986689) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(986504..986689) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(986725..986743) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(986736) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(986754..986762) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 986763..986766 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986781..986800 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986791 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 986816..987712 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 986816..987712 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 987705..988964 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 987705..988964 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 988948 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 989012..989019 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 989031..989050 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 989036 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 989071..990297 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 989071..990297 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(989772) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 990302..993193 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 990302..993193 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 991583..991588 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 991604..991622 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991610 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 993201..993206 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 993221..993240 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 993236 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 993267..994211 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 993267..994211 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 994189 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 994270..994275 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 994291..994309 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 994294 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 994336..994548 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 994336..994548 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 994541 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(994579) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(994589..995467) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(994589..995467) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(994777) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(995505..995524) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995529) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(995538..995545) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 995565..995574 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 995586 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 995587..995606 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(995623..995637) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995624) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 995627..995713 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 995627..995713 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(995646..995650) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 995714..995965 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 995838..995924 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 995838..995924 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 995922 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(995934..996196) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 995967..996450 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(995977) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(996189..996208) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996196) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(996198..996266) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(996222..996227) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(996267..996785) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(996267..996785) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 996572..996580 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 996592..996610 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 996605 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(996816..996835) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996834) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(996851..996857) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 996934..996937 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 996952..996971 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 996957 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 996993..997334 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 996993..997334 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(997188..997330) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(997231) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(997331..997942) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(997331..997942) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 997335..998100 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(997407) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 997938..997942 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997950..997963 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997962 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(997967..997986) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(997990) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(998001..998004) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 998057 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(998120..998476) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(998120..998476) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(998124) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 998553..998558 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(998559..998578) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(998573) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 998574..998592 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 998574 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(998575..998838) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 998606..998797 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 998606..998797 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 998798..1000233 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(998871..999389) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(998871..999389) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(998883) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(999390..999477) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(999469..999488) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999477) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999502..999509) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(999514..1000593) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(999514..1000593) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(1000632..1000651) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1000643) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1000645..1000726) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1000740..1001177) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(1000740..1001177) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(1000771) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1001210..1001229) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1001224) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 1001227 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(1001243..1001250) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1001249..1001545) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1001292) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1001543..1001554) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1001549) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1001569..1001575) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1001605..1001612 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1001626..1001645 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1001635 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 1001665..1002408 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 1001665..1002408 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 1002401..1003627 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 1002401..1003627 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(1002960..1002978) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002975) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002994..1002999) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1003647..1004357 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 1003647..1004357 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 1004321 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1004375..1005565) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(1004375..1005565) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(1004385) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1004450) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1005589..1005608) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005610) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005622..1005627) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1005638..1007029) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(1005638..1007029) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(1007040..1007059) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1007045) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1007072..1007081) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1007095..1007409) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(1007095..1007409) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(1007454..1007954) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(1007454..1007954) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(1007481) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1007967..1007986) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1007969..1007973 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1007988) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1007989..1008008 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007990 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1008003..1008004) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1008021..1008027 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1008042..1008053 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008047 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 1008076..1010220 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 1008076..1010220 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(1008120..1008131) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1008123) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1008145..1008151) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1010257..1010263 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1010277..1010296 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1010287 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 1010342..1011403 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 1010342..1011403 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 1011475..1012407 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 1011475..1012407 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 1012422..1013834 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 1012422..1013834 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 1012425 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1013811 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1013895..1013902 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1013916..1013935 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1013921 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 1013980..1014555 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 1013980..1014555 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 1014299..1014302 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1014317 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1014319..1014338 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1014556..1014625 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1014626..1016953 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 1014626..1016953 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 1016935 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1016995..1017972) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(1016995..1017972) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(1017008) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1017986..1018005) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1018004) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1018019..1018025) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1018031..1018039 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018050..1018068 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018057 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1018099..1018875 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 1018099..1018875 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(1018591..1019212) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1018876..1019247 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1019190..1019209) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1019211) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1019223..1019232) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1019225..1019232 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019247..1019266 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019249 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1019288..1020328 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 1019288..1020328 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 1020341..1020748 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 1020341..1020748 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 1020719 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(1020785..1022074) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(1020785..1022074) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(1020815) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1022075..1022175) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1022174..1022193) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022175) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1022177..1022313) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1022208..1022214) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1022345..1022485) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1022345..1022485) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1022358) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1022504..1022523) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022523) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022536..1022543) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022567..1022573 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022587..1022606 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022590 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1022637..1023371 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1022637..1023371 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1023384..1024379 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1023384..1024379 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1024444..1025088 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1024444..1025088 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1025076 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1025116..1025119 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1025134..1025153 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1025141 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1025205..1026746 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1025205..1026746 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1026726 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1026785..1027180) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1026785..1027180) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1026802) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1027200..1027211) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027204) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1027226..1027232) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1027265..1027268 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1027276 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1027283..1027302 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1027329..1028609 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1027329..1028609 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1027756..1027775) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027770) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1027791..1027796) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1028596 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1028646) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1028648..1029793) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1028648..1029793) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1029794..1029860) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1029849..1029868) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1029866) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1029884..1029888) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1030173..1030180 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1030195..1030214 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1030197 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1030228..1030677 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1030228..1030677 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1030693..1030700 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1030715..1030734 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1030722 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1030749..1031741 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1030749..1031741 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1031742 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1031787..1031897 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1031875..1031882 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031898..1031917 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031899 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1031958..1032929 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1031958..1032929 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1032908 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1032961..1033542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1032961..1033542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1032984) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1033566..1033585) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033578) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033601..1033604) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1033613..1034707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1033613..1034707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1034704..1036143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1034704..1036143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1036150..1036710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1036150..1036710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1036160..1036179) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1036174) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1036735..1036754) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1036749) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1036769..1036776) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1036845..1038143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1036845..1038143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1036856) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1038197..1038215) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1038200) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1038229..1038235) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1038282..1039811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1038282..1039811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1039838..1039856) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1039848) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1039867..1039872 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1039871..1039876) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1039884 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1039888..1039906 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1039923..1040780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1039923..1040780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1040762 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1040808..1041041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1040808..1041041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1040841) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1041058..1041077) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1041061..1041062 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1041061 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1041065..1041080 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1041080) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1041082..1041937) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1041092..1041099) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1041264..1041271 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1041283..1041302 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1041289 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1041334..1041912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1041334..1041912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1041913..1042058 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1041959..1042858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1041959..1042858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1041982) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1042045..1042048 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1042060 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1042066..1042070 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1042104 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1042149..1043015 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1042885..1042903) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1042902) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1042918..1042924) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1042992..1042999 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043014..1043033 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043017 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1043075..1043344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1043075..1043344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1043336 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1043384) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1043387..1044856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1043387..1044856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1044853..1045053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1044853..1045053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1045054..1045172) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1045155..1045174) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045172) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045187..1045194) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1045260) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1045261..1045623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1045261..1045623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1045461..1045466 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1045482..1045500 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1045483 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1045492..1045731 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1045653..1045672) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045671) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045687..1045694) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1045713..1045720 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1045733 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1045734..1045753 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1045775..1046398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1045775..1046398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1046400..1046906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1046400..1046906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1046899 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1046957..1046964 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1046978..1046997 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1046987..1047086 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1046987 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1047087..1048586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1047087..1048586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1048594..1048601 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1048613 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1048615..1048634 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1048663..1049190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1048663..1049190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1049152 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1049204..>1049224) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(1049224,1049240) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 1049225..1049239 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <1049240..1049526 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<1049240..1049361) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1049246) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1049362..1050516) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1049362..1050516) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1050517..1050588) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1050571..1050590) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1050587) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1050604..1050609) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1050623..1051828) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1050623..1051828) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1051849..1051868 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1051854 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1051942..1053669 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1051942..1053669 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1053255..1053262 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1053277..1053296 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1053284 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1053699..1054025) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1053699..1054025) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1054143..1054580) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1054143..1054580) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1054152) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1054611..1054630) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1054631) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1054643..1054652) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1054700..1054707 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1054721..1054740 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1054733 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1054764..1058264 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1054764..1058264 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1058251..1061949 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1058251..1061949 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1061950..1062020 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1062021..1063196 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1062021..1063196 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1063193..1066585 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1063193..1066585 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1065840..1065846 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1065861..1065872 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1065868 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1065937..1066910) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1066599..1066901 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1066599..1066901 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1066881 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(1066955) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" SCAR 1066959..1066960 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_007" downshifts 1066979 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1067018..1067605) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1067018..1067605) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1067620..1067639) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1067639) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1067655..1067657) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1067660..1067666 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1067678 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1067681..1067699 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1067684..1067750 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1067751..1069595 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1067751..1069595 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1069596..1069663 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1069620 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1069725..1070204) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1069725..1070204) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1070224) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1070228..1070246) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1070257..1070265) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1070396..1070400 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1070413 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1070415..1070434 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1070436..1071260 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1070436..1071260 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1070648..1070654 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1070669..1070687 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1070676 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1071270..1072720 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1071290..1072657) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1071290..1072657) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1072689..1072696 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072710..1072729 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1072722 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1072781..1073644 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1072781..1073644 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1073662..1074675 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1073662..1074675 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1074658 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1074727..1074734 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1074749..1074768 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1074768..1074883 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1074768 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1074884..1075912 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1074884..1075912 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1075934 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1075963..1076472) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1075963..1076472) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1075982) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1076485..1076503) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1076501) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1076515..1076523) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1076522..1077184) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1076522..1077184) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1077203..1077209 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1077223..1077242 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1077232 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1077251..1078705 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1077251..1078705 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1078560..1078712) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1078595) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1078713..1079351) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1078713..1079351) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1079352..1079486) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1079400..1079405 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1079421..1079439 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1079422 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1079432..1079556 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1079472..1079491) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1079486) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1079506..1079513) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1079557..1080363 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1079557..1080363 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1080356 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1080391..1080990) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1080391..1080990) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1080410) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1080987..1082156) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1080987..1082156) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1082157..1082268) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1082269..1082979) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1082269..1082979) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1083023..1083042) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1083045) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1083055..1083064) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1083094..1083103 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1083117..1083136 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1083128 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1083164..1083850 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1083164..1083850 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1083847..1084605 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1083847..1084605 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1084602 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1084650..1085279) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1084650..1085279) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1085313..1085331) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085330) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1085346..1085351) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1085375..1086490) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1085375..1086490) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1085404) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1086499..1087767) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1086499..1087767) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1087793..1087804) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1087802) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1087818..1087824) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1087879..1088727) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1087879..1088727) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1087890) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1088732..1089181) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1088732..1089181) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1089202..1089221) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1089216) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1089237..1089238) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1089271..1091109) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1089271..1091109) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1089298) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1091191) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1091199..1091316) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1091199..1091316) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1091368..1091387) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1091382) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1091402..1091409) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1091423..1091914) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1091423..1091914) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1091932..1091935 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1091938..1091957) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1091950..1091969 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1091951 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1091956) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1091972..1091979) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1092013..1092909 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1092013..1092909 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1092896 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1092962..1093546) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" /label="yitM CDS" gene complement(1092962..1093546) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /label="yitM gene" downshifts complement(1092972) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1093543..1094472) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" /label="yitO CDS" gene complement(1093543..1094472) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /label="yitO gene" upshifts complement(1093630) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1094457..1094993) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" /label="yitP CDS" gene complement(1094457..1094993) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /label="yitP gene" promotor_-10 complement(1095029..1095048) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1095043) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1095063..1095066) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1095134..1095141 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1095156..1095175 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1095159 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="upshifts" CDS 1095171..1095518 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" /label="yizB CDS" gene 1095171..1095518 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /label="yizB gene" CDS 1095515..1096102 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" /label="yitQ CDS" gene 1095515..1096102 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /label="yitQ gene" CDS 1096122..1096415 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" /label="yitR CDS" gene 1096122..1096415 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /label="yitR gene" downshifts 1096395 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1096439 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS 1096551..1098167 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" /label="nprB CDS" gene 1096551..1098167 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /label="nprB gene" downshifts 1098155 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" CDS complement(1098214..1099065) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" /label="fakBB CDS" gene complement(1098214..1099065) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /label="fakBB gene" downshifts complement(1098231) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1098612..1098619 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1098634..1098653 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1098639..1099164 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1098641 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1099106..1099125) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1099129) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1099143..1099148 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1099163..1099181 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1099166 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1099203..1100045 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1099203..1100045 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1099698..1099706 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1099717..1099735 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1099717 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1100046..1100159 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1100160..1100519 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1100160..1100519 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1100508 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1100550..1100747) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1100550..1100747) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1100563) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1100748..1100944) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1100944) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1100946..1100957) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1100972..1100978) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1101004..1101816) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1101004..1101816) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1101854..1101873) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1101874..1101881 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1101874) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1101887..1101894) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1101893..1101912 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1101895 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1101937..1102704 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1101937..1102704 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1102713..1102719 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1102733 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1102734..1102753 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1102768..1103076 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1102768..1103076 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1103061 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1103106..1103371 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1103372..1104802 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1103372..1104802 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1104847..1105341 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1104847..1105341 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1105305 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1105479..1105486 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1105485 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1105500..1105519 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1105548..1106585 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1105548..1106585 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1106605..1107825 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1106605..1107825 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1107840..1108616 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1107840..1108616 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1108613..1109770 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1108613..1109770 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1109841..1110896 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1109841..1110896 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1110451,1110452) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1110730..1110749) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1110740) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1110889..1113981 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1110889..1113981 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1113969..1114928 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1113969..1114928 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1114891 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1114931..1115205) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1114956..1114962 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1114964) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1114977..1114988 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1114998 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1115014..1115193 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1115014..1115193 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1115203 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1115239..1115424) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1115239..1115424) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1115250) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1115453..1115472) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115470) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115483..1115490) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1115525..1115531 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1115543..1115562 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1115548 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1115605..1115614 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1115614 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1115627..1115646 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1115673..1116407 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1115673..1116407 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1116166..1116768) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1116388..1116393 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1116406 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1116406 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1116409..1116427 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1116489..1117046 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1116489..1117046 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1116748..1116767) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1116768) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1116782..1116786) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1117053..1117060 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1117075..1117094 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1117087 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1117137..1118090 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1117137..1118090 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1117754..1117758 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1117774..1117793 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1117787 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1118105..1118296 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1118105..1118296 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1118275 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1118320..1118660 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1118326..1118565) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1118326..1118565) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1118342) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1118578..1118597) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1118599) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1118611..1118620) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1118626..1118633 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118648..1118667 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118662 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1118730..1119668 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1118730..1119668 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1118807..1118816 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1118825 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1118828..1118843 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1119691..1120932 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1119691..1120932 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1119905..1119923) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1119913) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1119939..1119944) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1120783 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1120916 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1120957..1120966 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1120979..1120998 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1120981 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1120993..1121001 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1121008..1121793 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1121008..1121793 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1121013..1121031 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1121025 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1121794..1121878 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1121810..1121828) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1121827) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1121843..1121848) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1121846..1121853 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1121868..1121887 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1121880..1121984 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1121880 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1121985..1122971 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1121985..1122971 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1122968..1123957 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1122968..1123957 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1123963..1123969 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1123968..1124044 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1123968 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1124045..1124536 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1124045..1124536 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1124509..1125675 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1124509..1125675 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1125666 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1125751..1126701 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1125751..1126701 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1126718..1127629 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1126718..1127629 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1127643 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1127688..1127795 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1127768..1127773 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1127789..1127807 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1127797 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1127834..1128586 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1127834..1128586 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1128566 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1128621..1129613) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1128621..1129613) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1128642) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1129672..1129886) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1129672..1129886) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1129720) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1129905..1129924) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1129918) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1130173..1130180 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1130194..1130356 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1130195..1130214 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1130195 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1130357..1131994 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1130357..1131994 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1131888 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1131995..1132101 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1132102..1133037 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1132102..1133037 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1132145..1132164) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1132162) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1132180..1132186) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1133041..1133958 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1133041..1133958 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1133963..1135039 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1133963..1135039 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1135041..1135958 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1135041..1135958 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1135928 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1136008..1136011 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1136024 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1136026..1136045 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1136065..1137282 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1136065..1137282 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1137335..1137344 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1137357..1137372 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1137366..1137445 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1137366 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1137446..1138024 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1137446..1138024 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1138025..1138139 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1138076..1138095) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138080) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1138109..1138116) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1138142..1138155 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1138142 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1138205..1138600 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1138205..1138600 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1138436..1138536) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1138476) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1138598 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1138643..1139432 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1138643..1139299) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1138643..1139299) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1139329..1139347) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1139344) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1139362..1139367) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1139405..1139412 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1139426..1139445 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1139434..1139575 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1139434 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1139469..1139609 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1139469..1139609 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1139576..1140232 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1139576..1140232 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1140222 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1140227..1140349) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1140227..1140349) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1140267..1140356 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1140335..1140343 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1140354..1140372 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1140358..1140422 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1140358 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1140423..1141544 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1140423..1141544 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1141198..1141204 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1141216 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1141219..1141237 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1141430..1141438 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1141450..1141468 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1141457 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1141538..1141544 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1141559..1141570 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1141568 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1141591..1143603 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1141591..1143603 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1141666..1141673 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1141688..1141707 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1141700 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1143550 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1143604..1143905 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1143641..1143808) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1143641..1143808) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1143654) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1143828..1143846) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1143844) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1143862..1143867) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1143898..1143905 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1143907..1144032 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1143907 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1143913..1144051 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1143913..1144051 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1143920..1143939 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1143989 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1144122..1145021) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1144122..1145021) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1144153) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1144357..1144362 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1144369 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1144378..1144396 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1144385..1146286 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1145018..1145416) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1145018..1145416) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1145417..1145596) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1145588..1145607) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1145596) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1145619..1145626) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1145671..1146216) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1145671..1146216) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1145695) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1146217..1146419) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1146420..1146992) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1146420..1146992) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1146565..1146583) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1146574) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1146596..1146603) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1147021..1147040) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1147038) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1147054..1147057 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1147055..1147062) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1147070 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1147073..1147092 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1147117..1147485 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1147117..1147485 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1147514..1148149 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1147514..1148149 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1148168..1148968 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1148168..1148968 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1149031..1149882 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1149031..1149882 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1149841 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1149895..1150629) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1149895..1150629) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1149917) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1150751..1150755 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1150772..1150791 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1150786 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1150787..1150863 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1150864..1152708 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1150864..1152708 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1151191..1151210) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1151215) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1152710..1152717 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1152731..1152750 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1152737 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1152770..1152878 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1152770..1152878 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1152873 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1152957..1153667 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1152957..1153667 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1153642..1154259 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1153642..1154259 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1154243..1155352 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1154243..1155352 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1155352..1155552 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1155352..1155552 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1155549..1156319 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1155549..1156319 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1156316..1157326 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1156316..1157326 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1157345..1158160 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1157345..1158160 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1158134 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1158207..1158213 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1158226..1158245 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1158236 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1158296..1159072 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1158296..1159072 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1159061 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" promotor_-35 1159120..1159125 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1159141..1159159 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1159145 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1159157..1159171) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1159157) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1159173..1159856 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" /label="cotO CDS" gene 1159173..1159856 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /label="cotO gene" promotor_-35 complement(1159179..1159183) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1159851 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1159939 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1159950..1160396) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" /label="cotZ CDS" gene complement(1159950..1160396) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /label="cotZ gene" downshifts complement(1159971) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1160397..1160523) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1160524..1161012) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" /label="cotY CDS" gene complement(1160524..1161012) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /label="cotY gene" promotor_-35 1160692..1160698 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1160713..1160732 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1160731 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1161008..1161012 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1161021..1161035 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1161039 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1161049..1161068) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1161066) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1161082..1161091) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1161098..1161116) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1161115) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1161132..1161137) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1161149 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1161164..1161682) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" /label="cotX CDS" gene complement(1161164..1161682) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /label="cotX gene" downshifts complement(1161188) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" /label="downshifts" downshifts 1161193 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature complement(1161683..1161780) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1161781..1162098) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" /label="cotW CDS" gene complement(1161781..1162098) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /label="cotW gene" CDS complement(1162139..1162525) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" /label="cotV CDS" gene complement(1162139..1162525) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /label="cotV gene" promotor_-35 1162521..1162525 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1162533..1162547 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1162535 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1162545..1162564) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1162567) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1162569..1163073) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 1162622..1162627 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1162643..1162661 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1162645 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="upshifts" CDS 1162685..1163041 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" /label="yjcA CDS" gene 1162685..1163041 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /label="yjcA gene" promotor_-35 1163051..1163060 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1163058..1163077) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1163066..1163299) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" /label="protein remnant CDS" gene complement(1163066..1163299) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo /label="gene" upshifts complement(1163073) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="upshifts" S_feature 1163074..1163260 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1163074..1163091 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1163074 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="upshifts" promotor_-35 complement(1163091..1163100) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1163117) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" downshifts 1163217 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" upshifts complement(1163271) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1163272..1163281 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1163279..1163286) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1163295..1163314 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1163305 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" CDS 1163323..1163529 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" /label="yjzK CDS" gene 1163323..1163529 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /label="yjzK gene" CDS 1163366..1163581 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" /label="yjcB CDS" gene 1163366..1163581 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /label="yjcB gene" promotor_-35 1163553..1163562 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1163575..1163594 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1163580 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1163587..1163601) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1163601) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1163611..1163615) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1163611..1163760 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" /label="yjcZ CDS" gene 1163611..1163760 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /label="yjcZ gene" downshifts 1163701 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature 1163761..1163892 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1163893..1164147 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" /label="spoVIF CDS" gene 1163893..1164147 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /label="spoVIF gene" downshifts 1164132 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" /label="downshifts" downshifts complement(1164151) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" /label="downshifts" S_feature 1164177..1165277 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1164221..1166500) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1164221..1166500) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1164239) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1166375..1166549) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1166428..1166436 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166447..1166465 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1166451..1166586 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1166451 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1166537..1166556) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1166548) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1166564..1166570 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1166572..1166576) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166585..1166603 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166588 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1166617..1166871 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1166617..1166871 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1166847 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1166937) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1166944..1167366) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1166944..1167366) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1167370..1167885) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1167370..1167885) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1167922..1168644) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1167922..1168644) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1168683..1168702) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1168704) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1168753..1168760 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1168775..1168794 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1168779 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1168812..1168932 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1168812..1168932 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1168937 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1169000..1170121 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1169000..1170121 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1170114..1171286 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1170114..1171286 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1171269 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1171303..1171321 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1171313 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1171314..1172843 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1171319..1171864) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1171319..1171864) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1171340) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1171934..1173124) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1171934..1173124) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1173150..1173169) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1173154) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1173184..1173191) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1173218..1173225 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1173229 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1173239..1173258 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1173297..1173369 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1173297..1173369 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1173311..1173328) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1173325) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1173349..1173355) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1173359 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1173384..1174119) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1173404..1175052 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1173413) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1174121..1174209) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1174164) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1174210..1175439) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1174210..1175439) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1174332) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1175009 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1175440..1175525) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1175480..1175487 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1175502..1175521 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1175511..1175530) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1175515 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1175529) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1175543..1175549) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1175565..1175885 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1175565..1175885 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1175895 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1175940..1176037 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1176038..1176169 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1176038..1176169 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1176185..1176358 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1176185..1176358 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1176395..1176856 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1176395..1176856 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1176827..1176834 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1176849..1176868 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1176857..1177097 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1176857 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1177070..1177077 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1177091..1177109 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1177099 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1177122..1177625 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1177122..1177625 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1177637..1177921 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1177637..1177921 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1177891 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1177923) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1177934..1177937) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1178082..1178609 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1178082..1178609 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1178756..1178761 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1178774..1178793 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1178777 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1178783..1179100 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1178783..1179100 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1179101..1179336 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1179337..1180092 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1179337..1180092 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1180093..1180180 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1180137 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1180180..1180240) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1180211) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1180241..1180588) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1180241..1180588) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1180620..1180638) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1180633) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1180635..1181091) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1180649..1180657) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1181051..1181069 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1181063 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1181069..1181088) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1181091) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1181102..1181109) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1181139..1183085 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1181139..1183085 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1183061 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1183115..1183116 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1183116..1183214 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1183189..1183195 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1183210..1183229 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1183216..1183284 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1183216 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1183285..1183767 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1183285..1183767 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1183747 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1183813..1184319) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1183813..1184319) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1183837) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1184344..1184363) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1184350) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1184352..1184537) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1184538..1184933) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1184538..1184933) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1184956..1184974) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1184969) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1184971..1185671) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1184989..1184994) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1185077..1185084 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1185098..1185117 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1185109 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1185162..1185641 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1185162..1185641 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1185640 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1185681..1185875) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1185681..1185875) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1185716) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1185889..1185904) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1185905) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1185916..1185925) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1186041..1186370) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1186041..1186370) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1186407..1186426) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1186420) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1186422..1186989) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1186441..1186446) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1186474..1186478 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1186494..1186513 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1186498..1186999 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1186498 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1186990..1187979) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1186990..1187979) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1187980..1187999) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1187983) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1188013..1188018) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1188102..1188350) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1188102..1188350) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1188112) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1188346..1188350 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1188359..1188373 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1188368 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1188375..1188394) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1188384) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1188408..1188417) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1188465..1188472 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1188479..1188498) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1188486..1188505 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1188488) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1188499 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1188500..1188603 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1188512..1188519) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1188604..1190007 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1188604..1190007 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1189996 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1190047..1190520) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1190047..1190520) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1190051) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1190542..1190560) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1190560) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1190575..1190580) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1190645..1190812) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1190645..1190812) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1190648) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1190824..1190842) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1190833) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1190855..1190862) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1190939..1191838 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1190939..1191838 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1191847..1192245) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1191847..1192245) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1191877) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1192274..1192293) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1192293) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1192308..1192315) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1192346..1192921) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1192346..1192921) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1192361) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1192940..1192958) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1192955) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1192972..1192978) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1192996..1193002 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1193017..1193035 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1193018 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1193067..1196024 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1193067..1196024 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1196017..1196577 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1196017..1196577 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1196570 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1196615..1196733 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1196711..1196714 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1196730..1196749 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1196735 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1196774..1197415 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1196774..1197415 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1196783) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1197388 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1197494..1198120 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1197494..1198120 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1198122 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1198125) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1198151..1198429) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1198151..1198429) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1198169) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1198458..1198469) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1198471..1198477) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1198477) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1198479..1198895) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1198647 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1198648..1198667 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1198665..1198819 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1198820..1200010 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1198820..1200010 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1198893..1198912) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198895) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1198926..1198935) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1200033..1201211 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1200033..1201211 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1201252..1201440) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1201252..1201440) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1201268) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1201466..1201485) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1201469) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1201499..1201505) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1201527..1201534 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1201549..1201568 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201560 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1201575..1201594) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1201579) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1201609..1201616) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1201614..1202426 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1201614..1202426 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1202405 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1202472..1203224) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1202472..1203224) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1202481) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1203224..1203976) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1203224..1203976) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1204096..1205070) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1204096..1205070) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1204131) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1205091..1205110) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1205117) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1205119..1207625) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1205125..1205132) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1205153..1205159 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205174..1205192 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1205177 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1205202..1205699 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1205202..1205699 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1205700..1205813 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1205793..1205797 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205813..1205832 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1205815..1206087 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1205815 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1206088..1206510 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1206088..1206510 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1206550..1207728 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1206550..1207728 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1207559..1207659 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1207617..1207635) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1207619 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1207625) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1207647..1207655) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1207727 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1207836..1207843 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1207858..1207877 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1207883 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1207926..1209347 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1207926..1209347 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1209415..1210794 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1209415..1210794 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1209934..1209953) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209939) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1209967..1209974) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1210819 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1210829..1210836 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1210831..1210898 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1210899..1211912 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1210899..1211912 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1211918..1212937 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1211918..1212937 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1212962..1214041 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1212962..1214041 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1214038..1214874 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1214038..1214874 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1214922..1216190 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1214922..1216190 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1216134..1216137 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1216153..1216157 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1216155 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1216223..1216242 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1216223 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1216278..1217279 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1216278..1217279 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1216961..1217061) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1217001) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1217255 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1217356..1218798 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1217356..1218798 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1218795..1220288 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1218795..1220288 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1220327..1221091) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1220327..1221091) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1220346) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1220859,1220861) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1221118,1221125) /created_by="User" /modified_by="User" /label="TF8A" N_region 1221119..1221124 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1221127..1221447 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1221127..1221447 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1221456 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1221465..1221668) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1221484..1221621) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1221484..1221621) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1221508) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1221707..1221877) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1221707..1221877) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1221713) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1221877..1222623) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1221877..1222623) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1222458..1222477) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1222475) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1222493..1222500) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1222649..1222667) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1222662) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1222683..1222688) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1222733..1223734) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1222733..1223734) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1222762) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1223747..1224364) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1223747..1224364) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1224400..1224419) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224402) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1224404..1224501) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1224435..1224439) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1224481..1224500) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224501) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1224515..1224522) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1224546..1224565) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1224558) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1224640..1225956) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1224640..1225956) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1224655) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1226003..1226022) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1226019) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1226037..1226040) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1226239..1226246 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1226261..1226280 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1226273..1226344 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1226273 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1226345..1227295 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1226345..1227295 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1227283 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1227396..1227542 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1227396..1227542 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1227550..1229700 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1227550..1229700 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1228439..1228539 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1228499 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1228587 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1229712..1230683 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1229712..1230683 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1230040..1230681) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1230726) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1230751..1231117) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1230794) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1231097..1231112) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1231117) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1231124..1231133) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1231201..1232550) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1231201..1232550) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1231215) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1232590..1232597 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1232602..1232621) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1232610 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1232612..1232631 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1232620) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1232622..1232704) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1232632..1232639) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1232661..1232667 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1232682..1232701 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1232685 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1232687..1232706) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232704) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1232719..1233537 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1232719..1233537 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1232722..1232725) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1233515 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1233594..1233601 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233616..1233635 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1233620 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1233666..1234490 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1233666..1234490 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1234507..1235433 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1234507..1235433 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1235439..1236401 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1235439..1236401 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1236133..1236138 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1236154..1236172 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1236155 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1236406..1237413 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1236406..1237413 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1237416..1239065 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1237416..1239065 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1239059 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1239153..1240112 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1239153..1240112 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1240109..1241209 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1240109..1241209 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1241206..1242096 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1241206..1242096 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1242109..1243098 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1242109..1243098 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1242392..1243119) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1243088 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1243133..1244301 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1243141..1244190) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1243141..1244190) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1243164) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1244217..1244236) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244228) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1244251..1244258) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1244280..1245140) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1244280..1245140) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1245165..1245183) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1245182) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1245199..1245205) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1245214..1245221 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1245235..1245254 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1245242 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1245300..1245818 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1245300..1245818 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1245809 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1245883..1245889 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1245901..1246007 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1245901 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1245903..1245914 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1245982..1245985 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1246001..1246020 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246009 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1246057..1247256 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1246057..1247256 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1247245 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1247290..1247661 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1247333..1247557) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1247333..1247557) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1247637..1247643 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1247657..1247668 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1247663 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1247702..1248433 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1247702..1248433 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1248411 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1248472..1248480 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248491..1248509 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248499 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1248525..1249052 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1248525..1249052 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1249042..1249560 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1249042..1249560 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1249554..1249561 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1249575..1249594 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1249578 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1249593..1249704 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1249593..1249704 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1249667 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1249782..1250120 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1249782..1250120 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1250120..1250437 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1250120..1250437 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1250437..1250440 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1250456..1250475 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1250468 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1250508..1251410 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1250508..1251410 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1251401 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1251457..1251463 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1251469 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1251477..1251496 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1251498..1251708 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1251498..1251708 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1251666 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1251761..1252858 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1251761..1252858 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1251948..1251950 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1251952..1251956 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1251952 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1252870..1254117 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1252870..1254117 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1254108 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1254179..1254186 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1254201..1254220 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1254210 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1254243..1254668 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1254243..1254668 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1254657 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1254699..1255142) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1254699..1255142) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1254733) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1255169..1255188) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1255175) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1255203..1255206) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1255224..1255230 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255244..1255262 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1255250 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1255285..1255695 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1255285..1255695 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1255673 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1255722..1255892 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1255722..1255892 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1255893..1256570 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1255942..1256412) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1255942..1256412) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1255966) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1256434..1256453) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1256450) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1256452..1256559) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1256469..1256472) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1256528 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1256585..1258873) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1256585..1258873) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1256604) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1258874..1258936) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1258896..1258996) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1258936) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1259001..1259156) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1259001..1259156) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1259002) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1259189..1259208) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1259201) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1259203..1259288) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1259224..1259231) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1259289..1260248) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1259289..1260248) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1260249..1260300) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1260293..1260312) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1260305) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1260326..1260332) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1260417..1260420 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1260433 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1260436..1260455 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1260471..1261304 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1260471..1261304 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1261280 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1261335..1262099) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1261335..1262099) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1261356) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1262074..1263717) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1262074..1263717) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1263704..1264303) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1263704..1264303) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1264305..1264907) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1264305..1264907) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1264985) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1265004..1265116) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1265004..1265116) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1265117..1265120 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1265131..1265150) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1265136..1265155 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1265147 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1265152) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1265165..1265172) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1265218..1265904 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1265218..1265904 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1265908..1267272 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1265908..1267272 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1267269..1267949 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1267269..1267949 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1267978..1267983 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1267999..1268017 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1268002 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1268041..1268553 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1268041..1268553 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1268539 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1268584..1268590 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268604..1268615 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1268605 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1268636..1268773 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1268636..1268773 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1268746 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1268832..1268839 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268853..1268872 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1268855..1269174 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1268855 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1268887..1269040 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1268887..1269040 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1269152..1269161 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1269174..1269193 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1269176..1269277 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1269176 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1269278..1270633 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1269278..1270633 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1270624 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1270676..1271008) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1270676..1271008) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1271024..1271043) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1271034) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1271036..1271424) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1271059..1271064) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1271096..1271196 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1271156 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1271203..1271358 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1271203..1271358 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1271367..1271374 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1271381..1271398 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271398 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1271409..1271428) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1271424) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1271442..1271448) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1271446..1271628 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1271446..1271628 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1271596 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1271653..1271661 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1271672..1271690 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1271678..1271760 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1271678 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1271761..1272225 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1271761..1272225 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1272210 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1272240..1273361) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1272240..1273361) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1272649..1272657 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1272671..1272690 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1272674..1273452 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1272674 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1273390..1273401) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1273410) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1273416..1273422) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1273453..1274004 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1273453..1274004 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1273972 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1274032..1274844) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1274032..1274844) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1274804..1274823) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1274818) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1274837..1274842) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1274945..1274951 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1274962..1275036 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1274962 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1274965..1274976 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1275037..1276731 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1275037..1276731 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1276744..1277757 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1276744..1277757 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1277742 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1277783..1279618) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1277783..1279618) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1277832) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1279622..1280557) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1279622..1280557) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1280528..1280539) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1280538) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1280554..1280560) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1280594..1282996) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1280594..1282996) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1280626) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1282844..1283046) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1283035..1283053) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1283046) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1283067..1283074) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1283113..1283120 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1283134..1283153 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1283146 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1283177..1283842 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1283177..1283842 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1283711..1283730) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1283728) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1283744..1283753) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1283837..1283844 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1283859..1283878 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1283872 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1283898..1284031 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1283898..1284031 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1283919..1284893 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1283919..1284893 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1283982 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1284881 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1285003..1285011 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1285025..1285033 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1285035 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1285038..1285124 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1285097..1285104 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1285118..1285137 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1285126 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1285157..1285912 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1285157..1285912 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1285909..1287054 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1285909..1287054 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1287055..1288214 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1287065..1287259) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1287065..1287259) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1287072) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1287302..1287313) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287312) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1287328..1287334) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1287390..1288091) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1287390..1288091) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1287424) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1288092..1288172) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1288164..1288183) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1288172) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1288188..1288195 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1288197..1288204) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1288209..1288228 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1288216 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1288262..1289158 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1288262..1289158 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1289152 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1289263..1289267 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289283..1289302 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1289287 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1289332..1290681 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1289332..1290681 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1290669 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1290730..1290736 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1290750..1290761 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1290758..1290825 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1290758 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1290826..1290981 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1290826..1290981 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1290984..1291160 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1290984..1291160 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1291050..1291150 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1291110 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1291156 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1291203..1292225) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1291203..1292225) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1291226) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1292270..1292289) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1292286) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1292301..1292307) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1292414..1292422 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1292430 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1292433..1292451 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1292478..1294694 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1292478..1294694 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1294469..1295409) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1294547..1294554 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1294569..1294588 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1294571 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1294691..1295188 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1294691..1295188 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1295189..1295428 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1295278..1295403 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1295278..1295403 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1295396 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1295437..1296498) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1295437..1296498) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1295454) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1296506..1297699) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1296506..1297699) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1296566 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1297786) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1297792..1297948) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1297792..1297948) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1297983..1298002) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1297984) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1298018..1298025) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1298028..1298031 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1298032..1298811) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1298032..1298811) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1298047..1298066 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1298056 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1298504..1298511 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1298524..1298543 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1298539 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1298546..1298863 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1298833..1298840 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1298841..1298860) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1298855..1298874 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298855) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1298865 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1298876..1298883) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1298906..1300102 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1298906..1300102 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1300084..1300091 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1300106..1300125 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1300125 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1300141..1300241 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1300141..1300241 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1300240 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1300326..1301543 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1300326..1301543 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1301540..1302247 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1301540..1302247 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1302205..1302834 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1302205..1302834 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1302849..1303385 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1302849..1303385 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1303232..1303425) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1303385 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1303426..1303746) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1303426..1303746) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1303484) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1303747..1303836) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1303772..1303778 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1303793..1303811 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1303803 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1303804..1303888 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1303818..1303837) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1303835) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1303852..1303855) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1303862..1303869 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1303884..1303903 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1303890..1303948 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1303890 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1303946) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1303949..1304206 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1303949..1304206 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1304200 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1304292..1304723 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1304292..1304723 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1304751..1306271) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1304751..1306271) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1304763) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1305472..1305478 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1305492..1305503 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1305498 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1306279..1306298) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1306300) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1306398..1306405 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1306420..1306439 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1306422 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1306464..1306901 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1306464..1306901 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1306884 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1306941..1307726) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1306941..1307726) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1306960) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1307422) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1307698..1308510) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1307698..1308510) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1308541..1308559) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1308557) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1308573..1308580) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1308648..1308870) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1308680) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1308893..1310992) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1308893..1310992) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1308915) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1310993..1311243) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1311203..1311303) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1311243) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1311279..1311284 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1311294 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1311300..1311318 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1311357..1312400 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1311357..1312400 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1312401..1312492 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1312469..1312473 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1312490..1312509 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1312494 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1312539..1312583 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1312539..1312583 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1312560 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1312605..1312712 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1312713..1313372 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1312713..1313372 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1313365..1313814 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1313365..1313814 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1313807..1314538 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1313807..1314538 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1314556..1315053 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1314556..1315053 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1315054..1315330 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1315288 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1315298) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1315367..1315611) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1315408) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1315612..1315968) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1315612..1315968) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1315999..1316018) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1316016) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1316053..1316071 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1316058 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1316137..1316883 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1316137..1316883 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1316938 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1317286..1317294 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1317308..1317327 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1317312 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1317364..1318563 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1317364..1318563 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1317446..1317452 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1317467..1317485 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1317473 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1318532..1318534 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1318554..1318572 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1318566 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1318579..1318806 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1318579..1318806 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1318656..1318675) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1318664) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1318807..1318902 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1318903..1319601 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1318903..1319601 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1319554..1320380) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1319582..1319833 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1319582..1319833 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1320083..1320098 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1320106..1320317 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1320106 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1320282 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1320369..1320388) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1320391) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1320404..1320411) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1320456..1320463 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1320478..1320497 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1320480 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1320516..1320806 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1320516..1320806 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1320843..1320926) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1320886) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1320927..1321112) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1320927..1321112) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1321145..1321164) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1321156) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1321158..1321502) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1321178..1321185) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1321211..1321216 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1321232..1321251 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1321239 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1321278..1321472 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1321278..1321472 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1321448 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1321493..1321511) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1321509) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1321528..1321533) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1321771..1322397 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1321771..1322397 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1322328 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1322454..1322459 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1322466 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1322475..1322493 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1322515..1323852 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1322515..1323852 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1323903..1324400 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1323903..1324400 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1324249..1324255 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1324264 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1324270..1324288 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1324374 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1324495..1324501 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1324512..1324531 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1324524 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1324528..1324635 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1324636..1326549 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1324636..1326549 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1324785..1324804) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1324802) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1324817..1324826) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1324953..1324972) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1324978) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1324986..1324992) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1326530 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1326606) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1326817..1326836) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1326826) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1326850..1326857) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1326901..1326920 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1326911 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1326956..1328047 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1326956..1328047 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1327696 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1328026 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1328060..1328278) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1328071..1328328 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1328265..1328284) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1328278) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1328300..1328307) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1328329..1329294 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1328329..1329294 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1329312..1329319 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1329334..1329353 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1329346 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1329357..1330223 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1329357..1330223 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1330078..1330082 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1330099..1330118 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1330107 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1330225 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1330270..1330421 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1330270..1330421 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1330270..1330421 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1330399..1330405 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1330419..1330430 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1330423 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1330452..1332551 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1330452..1332551 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1332569..1332573 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1332589..1332608 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1332600 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1332649..1332915 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1332649..1332915 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1332915..1334627 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1332915..1334627 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1334614 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1334667..1334673 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1334688..1334699 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1334691 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1334718..1334957 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1334718..1334957 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1334738..1336077) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1335035..1336063 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1335035..1336063 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1336033 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1336078..1336758) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1336078..1336758) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1336768..1336787) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1336791) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1336802..1336809) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1336843..1336850 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1336864..1336882 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1336870 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1336893..1338860 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1336893..1338860 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1337333..1337348) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1337345) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1338831 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1338904..1338906 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1338922..1338941 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1338932 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1338974) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1338998..1339864 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1338998..1339864 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1339844 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1339903..1340676) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1339903..1340676) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1339920) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1340708..1340727) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1340718) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1340951..1340970 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1340964 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1340966..1341069 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1341013..1343127 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1341013..1343127 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1342306..1342324) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1342318) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1342340..1342345) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1343108 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1343200..1343208 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1343220..1343238 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1343232 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1343291..1345111 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1343291..1345111 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1345122..1346303) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1345122..1346303) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1345156) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1346331..1346350) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1346347) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1346379..1346397) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1346391) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1346393..1346461) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1346412..1346417) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1346455..1346474) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1346461) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1346505..1346666) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1346505..1346666) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1346689..1346708) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1346702) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1346722..1346729) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1346803..1346810 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1346822 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1346823..1346841 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1346870..1347781 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1346870..1347781 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1346875) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1347324..1347332 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1347346..1347363 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1347349 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1347766 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1347825..1348289) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1347825..1348289) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1347843) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1348319..1348338) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1348329) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1348353..1348360) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1348415..1349707) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1348415..1349707) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1348437) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1349731..1349750) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1349735) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1349766..1349770) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1349783..1350277) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1349783..1350277) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1350293..1350312) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1350309) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1350326..1350335) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1350334..1351194) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1350334..1351194) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1351215..1351234) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1351228) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1351265..1351272 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1351288..1351307 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1351301 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1351337..1352101 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1351337..1352101 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1352102..1352250 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1352231..1352249 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1352252..1352401 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1352252 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1352299) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1352402..1354132 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1352402..1354132 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1354198..1354716 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1354198..1354716 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1354714 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1354759..1354764 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1354777..1354796 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1354780 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1354812..1355360 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1354812..1355360 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1355361..1355512 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1355513..1356736 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1355513..1356736 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1356699..1356717) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1356709) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1356715 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1356732..1356737) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1356785..1356792 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1356804..1356905 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1356804 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1356807..1356826 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1356822..1356905 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1356822..1356905 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1356862 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1356916..1356921 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1356936..1357220 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1356936 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1356938..1356956 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1357197..1357203 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1357217..1357228 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1357222..1357309 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1357222 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1357298..1357317 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1357311 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1357382..1357621 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1357382..1357621 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1357622..1357730 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1357731..1358249 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1357731..1358249 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1358286..1358293 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1358307..1358326 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1358321 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1358383..1358580 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1358383..1358580 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1358576 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1358621..1358717 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1358718..1359161 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1358718..1359161 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1359162..1359269 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1359237..1359242 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1359257..1359276 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359271 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1359310..1360191 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1359310..1360191 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1360170 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1360226..1360233 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1360248..1360267 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1360253 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1360303..1360779 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1360303..1360779 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1360769..1361662 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1360769..1361662 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1361678..1362133 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1361678..1362133 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1361949..1361968) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1361962) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1361982..1361990) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1362127 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1362172..1362179 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1362193..1362212 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1362194 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1362238..1362948 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1362238..1362948 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1362247) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1362357..1362361) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1362357) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1363018..1364142 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1363018..1364142 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1364154..1364160 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1364174..1364185 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1364176 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1364180..1364194) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1364204..1364208) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1364204..1364449 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1364204..1364449 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1364205) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1364437 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1364482..1365432 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1364486..1365289) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1364486..1365289) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1364498) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1365340..1365359) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1365349) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1365373..1365380) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1365405..1365412 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1365427..1365446 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1365434..1365525 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1365434 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1365526..1366068 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1365526..1366068 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1366140..1366586 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1366140..1366586 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1366594 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1366979..1366986 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1366999 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1367001..1367020 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1367052..1367627 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1367052..1367627 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1367605 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1367668..1368633) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1367668..1368633) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1367681) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1367977..1367978 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1367996..1368015 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1368002..1368726 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1368002 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1368654..1368672) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1368675) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1368687..1368692) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1368713..1368719 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1368729 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1368733..1368752 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1368770..1369369 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1368770..1369369 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1369420..1370439 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1369420..1370439 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1370457..1371749 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1370457..1371749 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1371710..1372231 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1371710..1372231 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1372231..1372704 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1372231..1372704 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1372697..1372930 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1372697..1372930 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1372909 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1372975..1372980 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1372997..1373015 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1373005 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1373017..1373103 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1373093..1373096 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1373105 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1373111..1373130 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1373154..1374911 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1373154..1374911 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1374923..1376737 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1374923..1376737 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1375360..1375379) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1375370) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1375394..1375401) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1376788..1376797 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1376809..1376824 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1376813 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1376847..1377542 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1376847..1377542 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1377547..1378680 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1377547..1378680 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1378681..1379373 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1378681..1379373 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1379370..1380563 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1379370..1380563 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1380541 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1380612..1380618 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1380632..1380643 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1380640 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1380685..1380692 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1380707..1380726 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1380712..1380803 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1380712 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1380767..1380774 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1380788..1380807 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1380805 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1380843..1381598 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1380843..1381598 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1380991) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1380993..1380995) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1381595..1382506 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1381595..1382506 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1382521..1384428 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1382521..1384428 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1384413 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1384497..1384504 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1384515..1384534 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1384518 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1384573..1385154 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1384573..1385154 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1385139 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1385183 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1385188..1385457) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1385188..1385457) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1385193) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1385458..1385523) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1385504..1385523) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1385523) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1385576..1385583 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1385594..1385613 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1385598 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1385638..1387260 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1385638..1387260 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1387248 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1387317..1388228 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1387317..1388228 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1388233 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1388262..1389494) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1388262..1389494) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1388273) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1389512..1389531) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1389536) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1389546..1389551) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1389604..1389738) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1389604..1389738) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1389615) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1389760..1389778) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1389771) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1389773..1389838) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1389794..1389799) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1389839..1390846) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1389839..1390846) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1390892) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1390893..1390901) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1390915..1390923) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1391033..1391042 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1391054 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1391055..1391070 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1391057..1391129 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1391130..1391408 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1391130..1391408 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1391406 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1391440..1393069) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1391451..1391555 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1391463) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1391537..1391544 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1391556..1391575 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1391557 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1391598..1392884 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1391598..1392884 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1392900..1393733 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1392900..1393733 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1393066..1393084) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1393081) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1393100..1393105) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1393796..1394461 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1393796..1394461 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1394445 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1394552..1394558 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1394573..1394592) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1394573..1394592 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394585 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1394587) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1394616..1396349 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1394616..1396349 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1395744..1396348) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1396338 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1396383..1398050) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1396383..1398050) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1396393) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1398056..1398265) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1398056..1398265) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1398302..1398321) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1398324) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1398326..1398503) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1398336..1398339) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1398504) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1398506..1398517) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1398531..1398537) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1398576..1398583 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398597..1398616 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398613 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1398651..1399424 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1398651..1399424 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1399395 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1399460..1400014) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1399460..1400014) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1399471) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1400036..1400055) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1400046) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1400070..1400077) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1400099 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1400123) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1400124..1400282) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1400124..1400282) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1400189..1400332) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1400189..1400332) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1400278..1400282 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1400283..1400351) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1400292..1400306 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1400319 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1400335..1400354) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1400364) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1400367..1400376) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1400438..1400445 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400459..1400478 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1400463 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1400496..1401167 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1400496..1401167 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1400835..1400844 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400857..1400875 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1400869 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1401114 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1401342..1401347 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1401364..1401383 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1401365..1401590 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1401365 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1401369..1401388) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1401385) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1401489..1401497) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401495) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1401511..1401519) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1401591..1402706 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1401591..1402706 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1402710..1403687 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1402710..1403687 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1403688..1403801 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1403722..1403741) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1403739) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1403756..1403759) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1403802..1405130 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1403802..1405130 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1403946..1403953 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1403968..1403987 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1403971 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1405135..1406547 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1405135..1406547 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1406544 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1406592..1406966) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1406592..1406966) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1406640) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1406997..1407016) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1407007) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1407170..1407175 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1407191..1407209 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1407201 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1407205..1407314 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1407237) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1407298..1407305 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1407316 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1407320..1407339 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1407335..1407545 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1407335..1407545 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1407385..1407504 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1407385..1407504 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1407391) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1407491 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1407536..1409139 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1407544..1409016) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1407544..1409016) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1407562) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1409017..1409112) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1409095..1409114) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1409112) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1409119..1409122 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1409129..1409136) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1409137..1409156 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1409141 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1409201..1409467 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1409201..1409467 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1409449 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1409500..1410138) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1409500..1410138) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1409525) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1410159..1410178) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1410183) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1410193..1410197) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1410208..1410214 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1410229..1410247 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1410230 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1410268..1410277 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1410290..1410309 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1410294..1410377 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1410294 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1410378..1410566 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1410378..1410566 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1410383) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1410559 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1410581) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1410589..1410592) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1410636..1410639 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1410656..1410675 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1410659 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1410706..1411503 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1410706..1411503 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1411529..1411957 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1411529..1411957 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1411914 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1411958..1412911 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1412033) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1412035..1412949) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1412035..1412949) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1413015..1413034) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1413023) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1413049..1413056) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1413301..1414866) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1413301..1414866) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1414901..1414920) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1414912) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1414934..1414941) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1415151..1417091 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1415151..1417091 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1417081..1417350 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1417081..1417350 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1417316..1417320 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1417334..1417353 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1417347 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1417350..1417871 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1417350..1417871 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1417868..1418161 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1417868..1418161 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1418201..1418812) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1418201..1418812) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1418215) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1418844..1418863) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1418853) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1418878..1418881) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1419068) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1419085..1419273) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1419085..1419273) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1419139) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1419295..1419314) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1419312) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1419327..1419334) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1419340..1419359 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1419347 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1419386..1421224 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1419386..1421224 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1421281..1421598 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1421281..1421598 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1421572 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1421647) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1421654..1421863) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1421654..1421863) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1421877..1421896) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1421892) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1421946..1422575) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1421946..1422575) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1421977) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1422477..1422495) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1422483) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1422507..1422515) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1422610..1422621) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1422615) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1422627..1422632 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1422636..1422642) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1422648..1422666 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1422648 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1422649..1422729 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1422730..1424058 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1422730..1424058 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1423914..1424061) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1423957) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1424059..1424649 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1424062..1424547) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1424062..1424547) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1424559..1424578) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1424587) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1424593..1424600) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1424650..1425579 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1424650..1425579 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1425164..1425183 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1425173 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1425603..1425606 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1425621..1425640 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1425629 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1425677..1425958 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1425677..1425958 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1425947 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1426021..1426024 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1426037..1426163 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1426037 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1426042..1426048 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1426164..1427375 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1426164..1427375 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1427385..1427389 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1427404..1427423 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1427423 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1427450..1430896 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1427450..1430896 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1430462..1430480) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1430482) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1430496..1430501) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1430876 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1430921 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1430953) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1430965 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1431299..1432219) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1431299..1432219) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1431305) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1432259..1432278) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1432274) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1432292..1432299) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1432354..1432361 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1432375..1432394 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1432376..1432481 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1432376 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1432483..1432573 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1432483 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1432489..1432492 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1432507..1432523 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1432574..1433491 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1432574..1433491 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1433520 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1433539 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1433540..1433545 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1433599..1433604 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1433619..1433637 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1433627..1433730 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1433627 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1433731..1434801 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1433731..1434801 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1434834..1436702 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1434834..1436702 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1436702..1437325 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1436702..1437325 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1437328..1437660 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1437328..1437660 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1437687..1438580 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1437687..1438580 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1438555 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1438612..1438974) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1438612..1438974) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1438631) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1438967..1438971 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1438980..1438993 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1438998..1439017) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1439002..1439113 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1439002 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1439010) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1439032..1439039) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1439114..1439560 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1439114..1439560 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1439146..1439153 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439165..1439184 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439170 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1439569..1439576 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439590..1439609 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439601 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1439644..1440684 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1439644..1440684 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1440607..1440625) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1440612) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1440641..1440646) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1440664 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1440848..1440857 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1440871..1440890 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1440885 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1440916..1441314 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1440916..1441314 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1440920) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1441330..1441569 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1441330..1441569 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1441548 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1441636..1441643 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1441654..1441673 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1441659 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1441685..1442134 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1441685..1442134 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1442120 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1442189..1442461 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1442189..1442461 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1442266..1442489) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1442464..1442584 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1442464..1442584 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1442491..1442614) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1442534) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1442585..1442690 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1442615..1442627) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1442622) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1442642..1442648) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1442671..1442675 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1442691..1442710 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1442692..1442783 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1442692 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1442784..1443338 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1442784..1443338 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1443343..1443828 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1443343..1443828 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1443795 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1443839..1445065) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1443839..1445065) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1443840..1445114 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1445066..1445167) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1445089..1445096 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1445108..1445127 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1445116..1445245 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1445116 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1445162..1445180) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1445177) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1445197..1445202) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1445246..1446028 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1445246..1446028 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1445808..1445814 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1445828..1445839 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1445839 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1446030..1447055 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1446030..1447055 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1446939 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1447072..1448319) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1447072..1448319) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1447099) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1448236..1448242 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1448256..1448267 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1448260 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1448316..1448501) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1448316..1448501) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1448334..1448338 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1448354..1448373 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1448363..1448498 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1448363 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1448392..1448411) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1448402) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1448425..1448432) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1448469..1448476 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1448490..1448509 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1448500 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1448529..1449047 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1448529..1449047 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1449069..1449248 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1449069..1449248 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1449228 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1449271) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1449275..1449278) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1449329..1449334 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449350..1449368 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1449351 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1449394..1449975 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1449394..1449975 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1449976 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1450032..1450514) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1450032..1450514) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1450051) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1450504 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1450537..1450556) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1450556) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1450570..1450577) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1450614..1450620 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1450632..1450651 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1450634 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1450674..1451570 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1450674..1451570 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1451641..1453260 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1451641..1453260 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1453232 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1453294..1453297 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1453312..1453385 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1453312..1453331 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1453312 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1453369) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1453386..1453817 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1453386..1453817 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1453887..1454822 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1453887..1454822 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1454489..1455941) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1454862..1455215 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1454862..1455215 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1455212..1457362 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1455212..1457362 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1455922..1455940) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1455941) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1455955..1455961) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1457345 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1457417..1457422 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1457438..1457456 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1457438 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1457479..1459419 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1457479..1459419 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1459215..1459221 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1459236..1459244 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1459242 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1459392 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1459437..1459504 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1459474..1459478 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1459494..1459513 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1459506..1459594 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1459506 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1459595..1461079 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1459595..1461079 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1461080..1461190 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1461191..1462165 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1461191..1462165 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1462166..1463521 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1462166..1463521 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1463345..1463350 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1463366..1463384 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1463376 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1463582..1464682 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1463582..1464682 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1464683..1464804 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1464805..1465896 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1464805..1465896 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1465285..1465294 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1465307..1465322 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1465312 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1465318..1465418 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1465378 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1465928..1466839 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1465928..1466839 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1466857 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1466969..1467760 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1466969..1467760 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1467757..1468452 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1467757..1468452 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1468475..1469182 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1468475..1469182 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1469200..1469565 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1469200..1469565 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1469417..1469420 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1469436..1469455 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1469452 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1469566..1469738 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1469739..1471061 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1469739..1471061 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1469946) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1469950..1469954) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1469969..1469973) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1471097..1472245 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1471097..1472245 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1472219 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1472340,1472347) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1472341..1472346 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1472347..1472392 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1472357..1472364 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1472377..1472396 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1472394 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1472451..1473245 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1472451..1473245 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1473163..1473166 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1473181..1473200 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1473189 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1473258..1473359 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1473258..1473359 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1473346 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1473447..1474727 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1473447..1474727 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1474668..1474684) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1474673) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1474748..1474753 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1474769..1474787 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1474773 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1474810..1475055 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1474810..1475055 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1474971..1474979 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1474990..1475008 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1474998 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1475056..1475166 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1475158..1475177 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1475168 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1475218..1476054 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1475218..1476054 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1476061..1476753 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1476061..1476753 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1476750..1477205 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1476750..1477205 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1477212..1477484 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1477212..1477484 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1477473 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1477545..1478318 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1477545..1478318 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1478034..1478041 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478055..1478073 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478078 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1478319..1478411 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1478412..1478906 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1478412..1478906 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1478919..1478926 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478940..1478959 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478947 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1478969..1479195 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1478969..1479195 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1479162 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1479248..1482013 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1479248..1482013 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1482004 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1482059) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1482094..1482100 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1482115..1482126 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1482115 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1482158..1482532 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1482158..1482532 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1482564..1482568 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1482583 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1482584..1482603 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1482635..1483099 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1482635..1483099 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1483101..1484012 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1483101..1484012 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1484007..1484014 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1484029..1484048 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1484043 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1484052..1484168 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1484052..1484168 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1484195..1484740 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1484195..1484740 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1484389) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1484731 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1484744..1484861 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1484744..1484861 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1484914..1486221 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1484914..1486221 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1486222..1486336 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1486222..1486336 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1486367..1487281 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1486367..1487281 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1487265..1488551 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1487265..1488551 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1488548..1489642 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1488548..1489642 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1489627..1492842 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1489627..1492842 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1492839..1493609 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1492839..1493609 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1493609..1494544 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1493609..1494544 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1494513..1495232 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1494513..1495232 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1495211..1495861 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1495211..1495861 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1495863 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1495908..1495980 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1495960..1495967 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1495981..1496000 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1495982 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1496006..1496111 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1496006..1496111 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1496112..1496272 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1496273..1496974 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1496273..1496974 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1496986..1498050 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1496986..1498050 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1498099..1499247 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1498099..1499247 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1498188) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1498200..1498204) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1498222..1498223) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1499260..1499853 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1499260..1499853 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1499854..1499951 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1499952..1500725 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1499952..1500725 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1500630..1500637 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1500652..1500671 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1500653 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1500728..1501513 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1500728..1501513 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1501494..1501982 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1501494..1501982 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1501962 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1502009) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1502022..1503740) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1502022..1503740) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1503762..1503781) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1503776..1503781 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1503776) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1503794..1503799) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1503797..1503815 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1503801 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1503856..1506528 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1503856..1506528 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1505261..1505280) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1505272) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1505295..1505302) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1506534..1506553 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1506537..1506610 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1506537 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1506611..1507486 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1506611..1507486 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1507563..1507832 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1507563..1507832 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1507643..1507647) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1507648) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1507840..1508454 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1507840..1508454 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1508458..1508661 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1508458..1508661 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1508650 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1508742..1509962 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1508742..1509962 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1509801..1510376) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1509959..1512376 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1509959..1512376 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1510372..1510390) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1510376) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1510404..1510410) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1512227..1512231 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1512247..1512266 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1512258 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1512403..1512885 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1512403..1512885 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1512890..1513843 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1512890..1513843 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1513830..1515173 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1513830..1515173 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1515177..1516268 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1515177..1516268 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1516275..1517039 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1516275..1517039 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1516328 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1517033..1518979 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1517033..1518979 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1518888..1518894 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1518908..1518926 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1518924 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1518994..1519890 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1518994..1519890 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1519895..1520548 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1519895..1520548 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1520546..1520555 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1520569..1520588 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1520574 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1520621..1521265 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1520621..1521265 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1521026..1521032 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1521043 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1521047..1521065 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1521156..1521161 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1521177..1521195 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1521190 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1521266..1521336 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1521337..1521417 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1521337..1521417 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1521432 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1521477..1521849 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1521490..1521678) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1521490..1521678) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1521506) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1521552) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1521679..1521771) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1521753..1521772) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1521771) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1521788..1521791) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1521822..1521829 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1521844..1521862 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1521851 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1521890..1521893 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1521908..1521927 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1521916 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1521955..1522317 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1521955..1522317 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1522168) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1522333..1523994 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1522333..1523994 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1523995..1524084 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1524057..1524064 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1524078..1524097 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1524086 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1524133..1524795 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1524133..1524795 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1524821..1525723 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1524821..1525723 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1525701..1527749 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1525701..1527749 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1527785..1527792 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1527807..1527826 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1527813 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1527858..1528424 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1527858..1528424 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1528438..1529439 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1528438..1529439 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1529458..1530411 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1529458..1530411 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1530404..1531144 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1530404..1531144 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1531175..1531179 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1531195..1531214 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1531200 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1531228..1531461 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1531228..1531461 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1531442 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1531470..1531570 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1531530..1531600 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1531530 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1531601..1532350 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1531601..1532350 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1532322 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1532392..1532398 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1532410..1532429 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1532432 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1532451..1536011 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1532451..1536011 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1535945..1537015) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1536031..1537020 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1536031..1537020 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1537007 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1537057..1537542) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1537057..1537542) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1537060) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1537564..1537582) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1537580) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1537596..1537603) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1537645..1537651 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1537666..1537685 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1537668 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1537719..1538051 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1537719..1538051 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1537722) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1538065..1539405 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1538065..1539405 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1539406..1539510 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1539511..1539783 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1539511..1539783 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1539783..1540028 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1539783..1540028 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1540000 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1540045..1540149 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1540150..1540536 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1540150..1540536 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1540541..1541065 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1540541..1541065 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1541062..1541793 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1541062..1541793 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1541799..1541806 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1541820..1541839 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1541824 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1541872..1541913 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1541872..1541913 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1541933..1542280 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1541933..1542280 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1542282 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1542335..1542341 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1542354..1542422 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1542354 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1542355..1542374 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1542423..1543271 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1542423..1543271 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1543292..1543299 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1543312..1543330 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1543322 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1543342..1544109 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1543342..1544109 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1544141..1545871 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1544141..1545871 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1545378) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1545379..1545398) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1545413..1545420) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1545868..1546149 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1545868..1546149 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1545981 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1546150..1546269 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1546241..1546248 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1546262..1546281 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1546271 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1546322..1547479 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1546322..1547479 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1546394..1546494) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1546434) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1547508..1548410 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1547508..1548410 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1548400 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1548471..1549364 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1548471..1549364 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1549370..1549377 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1549392..1549411 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1549399..1549551 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1549399 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1549552..1551627 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1549552..1551627 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1551597 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1551659..1551664 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1551671 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1551680..1551698 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1551703..1553010 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1551703..1553010 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1553016..1553020 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1553037..1553056 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1553047 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1553078..1553992 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1553078..1553992 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1553117..1553121 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1553134 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1553137..1553156 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1554005..1554550 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1554005..1554550 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1554567..1555970 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1554567..1555970 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1556010..1556789 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1556010..1556789 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1556764 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1556808 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1556909..1556916 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1556929..1556947 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1556940..1557093 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1556940 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1557068..1557075 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1557090..1557109 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1557095 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1557169..1557558 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1557169..1557558 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1557558..1558010 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1557558..1558010 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" SCAR 1558011..1558012 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_004" CDS 1558067..1558831 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1558067..1558831 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1558841..1558847 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1558860..1559363 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1558860..1559363 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1558862..1558873 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1558876 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1559359..1559365 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1559380..1559399 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1559382..1559506 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1559382 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1559507..1560247 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1559507..1560247 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1560229 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1560274..1560348 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1560349..1561230 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1560349..1561230 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1561231..1561375 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1561376..1562098 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1561376..1562098 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1562100..1562657 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1562100..1562657 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1562604) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1562646..1562649 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1562664..1562683 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1562682..1562787 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1562682 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1562788..1563570 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1562788..1563570 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1563574..1564383 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1563574..1564383 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1564364..1564371 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1564386..1564405 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1564387 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1564445..1565596 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1564445..1565596 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1565603..1566871 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1565603..1566871 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1566904..1568598 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1566904..1568598 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1568599..1568706 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1568707..1573020 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1568707..1573020 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1573021..1573085 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1573031..1573248 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1573031..1573248 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1573057..1573063 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1573078..1573089 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1573087..1573154 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1573087 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1573137..1573143 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1573156..1573349 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1573156 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1573157..1573176 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1573350..1573820 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1573350..1573820 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1573671) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1573855..1574970 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1573855..1574970 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1573917..1574017) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1573957) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1574984..1575259 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1574984..1575259 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1575261..1575563 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1575261..1575563 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1575583..1577733 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1575583..1577733 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1577628..1577634 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1577643 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1577649..1577667 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1577730..1578008 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1577730..1578008 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1578025..1578378 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1578025..1578378 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1578369 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1578460..1579389 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1578460..1579389 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1579174..1579181 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1579195..1579214 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1579204 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1579408..1580358 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1579408..1580358 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1580391..1580397 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1580398..1580514 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1580398 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1580412..1580431 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1580515..1580784 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1580515..1580784 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1580767 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1580812..1580897 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1580878..1580881 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1580897..1580916 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1580899 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1580957..1583074 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1580957..1583074 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1582857 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1583058 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1583103..1583191 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1583192..1584151 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1583192..1584151 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1583260..1583268) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1583263) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1583282..1583289) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1583755..1583760 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1583776..1583794 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1583781 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1584191..1585420 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1584191..1585420 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1585409 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1585449..1585454 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1585464 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1585470..1585488 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1585498..1585755 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1585498..1585755 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1585756..1585810 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1585783 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1585852..1585861 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1585871..1585940 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1585871 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1585875..1585894 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1585941..1586834 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1585941..1586834 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1586837..1587439 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1586837..1587439 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1587493..1587512 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1587493..1587564 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1587493 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1587565..1588605 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1587565..1588605 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1588606..1588696 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1588697..1589911 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1588697..1589911 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1589942..1590814 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1589942..1590814 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1590285..1591469) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1590821 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1590914..1590917 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1590931 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1590933..1590952 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1590992..1592659 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1590992..1592659 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1591456..1591474) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1591473) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1591490..1591495) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1592647 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1592714..1592720 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1592734..1592745 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1592735 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1592775..1593512 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1592775..1593512 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1593509..1593721 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1593509..1593721 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1593749..1593768 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1593763 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1593852..1596215 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1593852..1596215 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1596216..1596316 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1596277..1596284 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1596299..1596318 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1596317 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1596359..1597084 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1596359..1597084 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1597071 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1597140..1597146 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1597159 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1597161..1597172 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1597223..1598431 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1597223..1598431 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1598389 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1598500..1598507 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1598520..1598539 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1598542 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1598554..1598557 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1598573..1598585 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1598587 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1598611..1599891 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1598611..1599891 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1599888..1601174 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1599888..1601174 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1601024 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1601175..1601228 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1601229..1601957 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1601229..1601957 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1601973..1601979 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1601991 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1601993..1602004 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1602004) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1602015..1602029) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1602038..1602042) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1602038..1602295 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1602038..1602295 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1602280 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1602312) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1602353..1602356 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1602371..1602390 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1602371 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1602425..1602940 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1602425..1602940 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1602876..1603214 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1602876..1603214 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1603281..1604147 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1603281..1604147 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1603344..1603444 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1603404 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1604107 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1604197..1604778 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1604197..1604778 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1604796..1606046 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1604796..1606046 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1606047..1606173 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1606153..1606160 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1606175..1606194 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1606175 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1606219..1607265 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1606219..1607265 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1607277 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1607322..1607387 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1607359..1607368 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1607381..1607396 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1607389 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1607433..1608608 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1607433..1608608 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1608609..1608708 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1608682..1608689 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1608703..1608722 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1608710..1608883 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1608710 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1608884..1610446 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1608884..1610446 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1610423 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1610515..1611309 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1610515..1611309 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1611064..1611069 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1611085..1611103 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1611105 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1611353..1611358 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1611369..1611508 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1611369 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1611374..1611392 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1611401) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1611412..1611425) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1611434..1611438) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1611445) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1611509..1611769 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1611509..1611769 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1611721 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1611753) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1611765 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1611810..1611984 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1611968..1611975 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1611986 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1611990..1612009 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1612035..1613078 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1612035..1613078 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1613091..1614269 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1613091..1614269 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1614251 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1614349..1614352 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1614361 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1614367..1614386 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1614417..1615946 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1614417..1615946 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1615948..1616379 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1615948..1616379 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1616362 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1616510..1616515 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1616531..1616549 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1616539..1616640 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1616539 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1616641..1617186 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1616641..1617186 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1617180 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1617187) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1617244..1617247 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1617262..1617281 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1617266 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1617319..1619895 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1617319..1619895 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1619911..1621794 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1619911..1621794 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1621697..1622191) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1621709 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1621719) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1621941..1621948 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1621963..1621982 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1621973..1622106 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1621973 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1621978..1622128) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1621978..1622128) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1622063 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1622192..1622647) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1622192..1622647) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1622648..1622739) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1622727..1622746) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1622739) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1622763..1622766) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1622802..1623359) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1622802..1623359) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1623450..1623451 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1623502) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1623508..1623864) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1623508..1623864) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1623924..1623937) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1623929) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1623943..1624767) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1623943..1624767) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1624789..1624808) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1624805) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1624820..1624826) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1624878..1626206) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1624878..1626206) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1624885) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1626229..1626248) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1626248) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1626262..1626270) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1626363..1626370 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1626378..1626397) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1626386..1626405 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1626389) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1626392 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1626410..1626417) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1626431..1626508 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1626431..1626508 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1626433) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1626486..1626662 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1626486..1626662 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1626643 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1626688..1626876 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1626871..1626890 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1626878 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1626942..1627649 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1626942..1627649 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1627660..1627666 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1627680..1627699 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1627684 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1627719..1628171 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1627719..1628171 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1628159 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1628185..1628538) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1628185..1628538) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1628226) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1628552..1628869) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1628552..1628869) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1628913..1628932) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1628921) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1628947..1628954) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1629006..1629281) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1629006..1629281) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1629007) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1629277..1629282 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1629298..1629316 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1629308..1629327) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1629318 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1629321) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1629340..1629349) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1629370..1629783 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1629370..1629783 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1629834 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1629840..1629859 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1629883..1630827 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1629883..1630827 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1630807..1630815 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1630826..1630844 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1630828 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1630867..1631088 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1630867..1631088 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1630878) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1630940..1630944) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1630944) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1630959..1630964) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1631088 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1631284..1631556 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1631284..1631556 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1631572..1631579 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1631593..1631612 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1631595 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1631638..1631868 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1631638..1631868 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1631869..1631945 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1631902 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1631947..1632054 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1632027..1632034 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1632048..1632067 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1632056 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1632111..1632503 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1632111..1632503 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1632463..1634565 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1632463..1634565 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1634583..1635572 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1634583..1635572 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1635532 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1635586..1636245) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1635601) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1635622..1636242 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1635622..1636242 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1636223 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1636258..1636262 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1636280..1636647 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1636280 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1636284..1636301 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1636290) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1636306..1637073) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1636306..1637073) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1637082..1637101) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1637105) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1637114..1637123) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1637227..1637232 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1637248..1637266 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1637248 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1637530..1637535 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1637552..1637570 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1637556..1637696 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1637556 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1637697..1638665 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1637697..1638665 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1638634 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1638729..1638737 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1638744 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1638748..1638767 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1638798..1640060 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1638798..1640060 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1640078..1641343 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1640078..1641343 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1641391..1641398 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1641413..1641432 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1641425 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1641453..1641860 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1641453..1641860 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1641459) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1641841..1641859 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1641866 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1641919) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1641919..1643253 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1641919..1643253 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1643230 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1643275..>1643324 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1643324..1643325 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1643325..1644077 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1643417..1643435) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1643435) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1643451..1643456) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1644078..1645469 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1644078..1645469 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1645500..1647101 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1645500..1647101 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1645616..1645921) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1645916..1645935) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1645921) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1645949..1645957) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1647099 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1647238..1648392) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1647238..1648392) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1647241) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1648291..1648469) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1648437..1648443 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1648452..1648471) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1648453..1648469 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1648463 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1648469) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1648486..1648489) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1648496..1648503 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1648518..1648537 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1648529..1648633 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1648530 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1648634..1649971 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1648634..1649971 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1649972..1650046 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1650003 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1650122..1651621 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1650122..1651621 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1651622..1651937 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1651895 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1652104..1652739) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1652104..1652739) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1652776..1652795) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1652785) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1652810..1652817) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1652927..1652934 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1652949..1652968 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1652951..1653149 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1652951 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1653150..1654565 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1653150..1654565 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1654555 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1654658) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1654667..1655851) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1654667..1655851) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1655852..1655931) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1655924..1655942) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1655935) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1655958..1655963) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1656243..1656250 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1656265..1656284 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1656273 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1656315..1656776 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1656315..1656776 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1656806..1657240 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1656806..1657240 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1656989..1657294) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1657087 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1657241..1658337 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1657296..1657581) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1657339) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1657576..1657595) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1657581) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1657607..1657612) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1657843) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1657843..1658103) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1657843..1658103) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1658124..1658143) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1658134) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1658156..1658165) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1658338..1658463 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1658338..1658463 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1658464..1658580 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1658507..1658671 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1658507..1658671 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1658555..1658564 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1658578..1658597 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1658582..1658892 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1658582 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1658873..1658880 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1658894..1658913 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1658894 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1658945..1659784 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1658945..1659784 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1658967..1658986) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1658988) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1659001..1659004) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1659744 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1659890) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1659891..1660197) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1659907..1660194) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1659907..1660194) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1659934) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1660021..1660029 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1660043..1660062 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1660045 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1660056..1660216 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1660188 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1660237..1660959) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1660237..1660959) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1660242) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1660984..1661003) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1660992) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1660994..1661118) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1661119..1661475) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1661119..1661475) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1661499..1661518) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1661516) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661534..1661538) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1661715) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1661721..1661921) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1661721..1661921) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1661904 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1661943..1661962) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1661955) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661975..1661984) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1662096..1662284) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1662096..1662284) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1662112) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1662253..1662260) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1662266) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1662313..1662332) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1662331) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1662347..1662354) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1662363..1662500 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1662363..1662500 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1662394..1662399 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1662414..1662432 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1662432..1662534 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1662432 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1662535..1662933 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1662535..1662933 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1662934..1663738 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1662998..1663432) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1662998..1663432) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1663014) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1663462..1663481) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1663478) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1663495..1663502) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1663739..1663927 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1663739..1663927 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1663928..1664013 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1663972 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1664042..1664048 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1664060..1664219 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1664060 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1664062..1664073 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1664220..1665782 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1664220..1665782 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1664523..1664542) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1664532) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1664557..1664564) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1665812..1666903 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1665812..1666903 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1666893..1668107 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1666893..1668107 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1668185..1668192 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1668207..1668226 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1668218 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1668254..1669060 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1668254..1669060 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1668868..1669966) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1669065..1669682 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1669065..1669682 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1669679..1671319 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1669679..1671319 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1669953..1669972) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1669966) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1669986..1669994) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1670959..1671725) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1671356..1671721 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1671356..1671721 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1671698 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1671718..1671998) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1671718..1671998) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1671727..1671858) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1671770) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1671818..1671827 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1671840..1671849) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1671841..1671860 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1671846 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1671848..1671946 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1671858) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1671860..1671990) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1671947..1672705 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1671947..1672705 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1671980 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1671996..1672015) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1671997) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1672030..1672037) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1672520..1672731) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1672684 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1672729..1673348 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1672732..1673271) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1672732..1673271) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1673272..1673286) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1673278) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1673300..1673306) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1673326..1673335 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1673348..1673363 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1673350 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1673389..1673823 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1673389..1673823 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1673681..1674028 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1673681..1674028 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1673824..1674156 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1674115..1674124 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1674136..1674151 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1674158..1674336 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1674158 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1674227..1674306 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1674227..1674306 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1674293 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1674365..1674982) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1674365..1674982) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1674366) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1675006..1675025) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675027) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1675039..1675046) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1675062..1675069 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1675081 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1675083..1675102 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1675132..1675449 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1675132..1675449 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1675149..1675167) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675152) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1675181..1675188) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1675468..1676121 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1675468..1676121 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1676124..1676131 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1676145..1676164 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1676158 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1676185..1676418 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1676185..1676418 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1676419..1676554 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1676522..1676529 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1676543..1676562 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1676556 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1676587..1678590 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1676587..1678590 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1676791..1676810) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1676808) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1678580 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1678592..1679250) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1678690 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1678691..1678710 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1678743..1679189 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1678743..1679189 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1679213..1679232 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1679221 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1679232..1679249) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1679250) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1679268..1679272) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1679275..1679493 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1679275..1679493 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1679505 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1679550..1679849 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1679567..1679740) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1679567..1679740) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1679580) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1679778..1679797) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1679785) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1679811..1679818) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1679820..1679828 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1679840..1679859) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1679840..1679858 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1679851..1679959 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1679851 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1679852) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1679874..1679881) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1679960..1680667 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1679960..1680667 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1680687..1680694 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1680706..1680725 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1680714 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1680756..1681118 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1680756..1681118 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1681136..1681139 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1681154..1681173 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1681165 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1681197..1681688 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1681197..1681688 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1681684 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1681719..1682147) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1681719..1682147) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1681736) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1682165..1682184) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1682177) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1682179..1682264) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1682198..1682205) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1682235..1682244 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1682254..1682363 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1682254 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1682257..1682276 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1682259..1682278) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1682264) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1682266..1682349) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1682293..1682296) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1682320 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1682381..1682773) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1682381..1682773) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1682394) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1682616..1682621 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1682637..1682655 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1682641 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1682751..1682755 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1682765..1682779 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1682780..1682799) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1682782 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1682795) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1682813..1682822) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1682854..1683000) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1682854..1683000) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1682875) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1683032..1683178) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1683032..1683178) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1683178..1683311 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1683178 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1683189..1683191 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1683194..1683205) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1683208) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1683220..1683226) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1683301..1683308 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1683313..1683405 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1683313 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1683323..1683342 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1683364) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1683406..1686135 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1683406..1686135 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1683426..1683430) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1683430) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1686136..1686206 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1686207..1686719 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1686207..1686719 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1686676 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1686745..1686751 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1686764 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1686766..1686777 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1686800..1686925 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1686800..1686925 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1686818) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1686939..1686945 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1686960..1686971 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1686962 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1686990..1687136 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1686990..1687136 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1687173..1687424 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1687173..1687424 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1687402 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1687445..1687450 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1687464..1687483 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1687468..1687559 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1687468 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1687560..1687925 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1687560..1687925 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1687941..1688240 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1687941..1688240 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1688216 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1688271..1688558) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1688271..1688558) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1688292) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1688358) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1688588..1688607) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1688600) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1688623..1688630) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1688646..1689227) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1688646..1689227) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1689228..1689358 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1689253..1689272) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1689270) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1689343..1689346 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1689360 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1689362..1689381 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1689397..1689804 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1689397..1689804 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1689800 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1689866..1689869 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1689884..1689903 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1689888..1690202 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1689888 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1690203..1692170 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1690203..1692170 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1692174..1694594 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1692174..1694594 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1694574 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1694602..1694791) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1694641..1694817) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1694641..1694817) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1694645) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1694792..1695202) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1694792..1695202) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1695175..1695194) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1695178) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1695209..1695216) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1695243..1695262) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1695244) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1695277..1695284) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1695291..1695310) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1695302) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1695324..1695333) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1695550..1695555 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1695568..1695587 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1695573 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1695586..1695650 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1695651..1697048 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1695651..1697048 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1697037 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1697082 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1697138..1697884) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1697261..1697268 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1697280 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1697281..1697300 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1697351..1698850 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1697351..1698850 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1697883..1697902) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697906) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1697916..1697925) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1698798 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1698918..1699181 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1698918..1699181 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1699440) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1699440..1700708) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1699440..1700708) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1700709..1700838) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1700839..1702380) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1700839..1702380) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1702381..1702702) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1702692..1702711) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1702703) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1702726..1702729) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1702929..1702936 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1702949..1702968 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1702956 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1702975..1703421 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1702975..1703421 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1703428..1704321 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1703428..1704321 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1703938..1703957 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1703946 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1704394..1704990 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1704394..1704990 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1704980 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1705039..1706238) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1705039..1706238) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1706239..1706310) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1706298..1706309) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1706310) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1706324..1706330) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1706408..1707943) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1706408..1707943) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1706420) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1707954..1708736) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1707954..1708736) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1708757..1709656) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1708757..1709656) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1709671..1709892) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1709671..1709892) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1709907..1711241) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1709907..1711241) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1711251..1712900) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1711251..1712900) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1711300..1711400 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1711360 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1712944..1714086) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1712944..1714086) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1714105..1714123) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1714122) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1714139..1714144) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1714177..1714482) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1714177..1714482) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1714472..1714645) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1714472..1714645) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1714753..1716285) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1714753..1716285) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1714764) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1716320..1716339) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1716320) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1716352..1716361) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1716421..1716813) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1716421..1716813) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1716452) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1716841..1716852) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1716848) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1716866..1716872) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1716920,1716927) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1716921..1716926 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1716927..1717032) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1717017..1717036) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1717032) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1717050..1717057) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1717306..1718781) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1717306..1718781) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1717318) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1718815..1719792) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1718815..1719792) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1719821..1719839) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1719833) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1719851..1719859) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1719926..1721317) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1719926..1721317) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1719940) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1720086 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1721107..1721113 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1721127..1721145 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1721138..1721471 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1721138 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1721318..1721422) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1721382..1721482) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1721422) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1721444..1721449 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1721465..1721483 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1721473 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1721531..1721538 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1721551..1721570 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1721554 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1721603..1722148 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1721603..1722148 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1722132 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1722242..1722314) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1722242..1722314) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1722340) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1722367..1722912) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1722367..1722912) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1722952..1722971) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1722966) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1722985..1722992) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1723228..1723458) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1723228..1723458) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1723242) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1723484..1723503) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1723496) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1723515..1723521) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1723550..1723569) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1723560) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1723573..1723580 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1723594..1723613 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1723598 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1723643..1725406 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1723643..1725406 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1725387 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1725507..1726364) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1725507..1726364) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1726410..1726429) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1726430) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1726443..1726450) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1726492..1727481 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1726492..1727481 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1726548..1727506) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1727538..1729019) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1727538..1729019) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1727551) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1729036..1733598) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1729036..1733598) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1732059..1732159 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1732119 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1733599..1733670) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1733650..1733669) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1733667..1733674 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1733670) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733684..1733691) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1733686 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1733689..1733708 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1733745..1734647 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1733745..1734647 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1734627 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1734699..1735814) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1734699..1735814) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1735811..1736704) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1735811..1736704) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1736709..1736728) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1736717 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1736727) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1736742..1736748) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1736757..1736775) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1736775) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1736791..1736796) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1736852..1737220) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1736852..1737220) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1737255..1737273) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1737278) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1737280..1737399) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1737285..1737293) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1737391..1737410) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1737399) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1737401..1737497) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1737425..1737432) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1737520..1738236) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1737520..1738236) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1737542) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1738274..1738293) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738283) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1738309..1738312) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1738337..1738343 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1738357..1738375 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1738362 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1738387..1738692 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1738387..1738692 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1738676 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1738763..1739533 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1738763..1739533 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1739515..1739522 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1739534 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1739537..1739556 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1739577..1740110 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1739577..1740110 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1740111..1740196 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1740153 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1740189..1741433) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1740189..1741433) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1740198..1740937 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1740203) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1741434..1741526) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1741527..1742990) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1741527..1742990) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1743008..1744042) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1743008..1744042) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1744054..1744125) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1744097) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1744126..1744217) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1744126..1744217) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1744245..1744264) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1744257) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1744279..1744286) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1744299..1744306 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1744320..1744339 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1744324 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1744366..1746408 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1744366..1746408 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1746416..1746425 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1746438..1746453 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1746441 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1746475..1746768 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1746475..1746768 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1746748 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1746793..1747140) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1746824) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1747141..1747545) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1747141..1747545) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1747546..1747641) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1747631..1747646) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1747631..1747750) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1747631..1747750) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1747641) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1747659..1747668) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1747746..1747752 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1747766..1747777 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1747777..1747985 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1747777 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1747820..1747942 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1747820..1747942 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1747986..1748279 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1747986..1748279 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1748280..1748373 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1748330 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1748395..1750080) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1748395..1750080) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1748407) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1750081..1750168) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1750160..1750178) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1750168) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1750192..1750199) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1750337..1750346 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1750356 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1750359..1750378 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1750405..1751856 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1750405..1751856 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1751832 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1751893..1752591) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1751893..1752591) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1751908) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1752626..1752645) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1752645) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1752647..1752860) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1752659..1752666) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1752861..1753538) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1752861..1753538) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1753539..1756028) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1753711..1754748 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1753711..1754748 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1754945..1754951 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1754966..1754977 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1754978 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1755005..1755688 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1755005..1755688 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1756029..1756334) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1756029..1756334) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1756335..1756436) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1756415..1756434) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1756436) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1756449..1756456) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1756464..1756566) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1756506) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1756567..1757745) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1756567..1757745) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1757771..1757790) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1757790) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1757804..1757813) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1757868..1758356) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1757868..1758356) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1757893) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1758381..1758536) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1758381..1758536) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1758576..1759331) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1758576..1759331) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1759584..1759589 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1759605..1759623 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1759620 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1759639..1759995 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1759639..1759995 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1759954..1760193) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1759954..1760193) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1759996..1760432 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1760194..1760295) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1760296..1760793) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1760296..1760793) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1760794..1760893) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1760894..1761805) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1760894..1761805) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1761827..1761838) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1761829) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1761853..1761859) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1762089..1762096 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1762105 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1762111..1762130 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1762152..1762634 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1762152..1762634 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1762644..1762898 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1762644..1762898 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1762899..1763003 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1763004..1763798 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1763004..1763798 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1763799..1764809 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1763922..1764794) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1763922..1764794) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1764895..1765773 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1764895..1765773 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1765886..1765945) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1765921) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1765946..1766377) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1765946..1766377) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1766397..1766416) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1766405) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1766407..1766640) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1766430..1766436) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1766641..1766659) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1766641..1767273) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1766641..1767273) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1766647) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1766675..1766680) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1767411..1767418 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1767433..1767452 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1767437 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1767499..1768419 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1767499..1768419 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1767930..1767949) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1767945) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1767964..1767971) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1768420..1769077 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1768916..1769278) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1768916..1769278) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1769339..1769551) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1769339..1769551) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1769590..1769597 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1769612..1769631 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1769615 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1769655..1769918 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1769655..1769918 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1769896 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1770295..1772895) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1770295..1772895) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1772896..1773005) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1772921..1772928 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1772943..1772962 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1772951..1773578 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1772951 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1772995..1773014) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1773005) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1773029..1773035) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1773051..1773510) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1773093) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1773555) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1773565..1774206) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1773565..1774206) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1774207..1774324) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1774301..1774320) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1774324) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1774334..1774336) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1774412,1774419) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1774413..1774418 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1774419..1774503 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1774419..1774496 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1774419..1774483) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1774419..1774503 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1774481 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1774514..1774846) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1774514..1774846) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1774528) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1774911..1775636) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1774911..1775636) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1775651..1776394) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1775651..1776394) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1776422..1776441) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1776441) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1776455..1776461) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1776472..1777047) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1776472..1777047) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1777053..1777754) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1777053..1777754) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1777784..1777803) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1777784) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1777788..1777803) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1777818..1777825) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1777818..1777825) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1777828) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1777831..1778313) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1777831..1778313) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1778352..1778369) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1778356) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1778367..1779308) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1778367..1779308) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1778400) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1779338..1779357) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1779346) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1779371..1779375) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1779379..1779388 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1779401..1779420 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1779409 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1779424..1779488 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1779460..1779465 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1779481..1779499 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1779490 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1779514..1780059 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1779514..1780059 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1780018 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1780086..1780409) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1780086..1780409) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1780093) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1780430..1780449) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1780441) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1780462..1780469) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1780530..1780536 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1780547 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1780551..1780570 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1780603..1781280 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1780603..1781280 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1781272 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1781370..1781906) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1781370..1781906) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1781393) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1781933..1781952) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1781953) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1781966..1781973) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1782043..1782825) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1782043..1782825) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1782052) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1782847..1782865) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1782866) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1782879..1782885) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1782922..1782929 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1782944..1782963 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1782948 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1782996..1783493 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1782996..1783493 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1783500..1783503 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1783519..1783538 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1783521 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1783557..1784534 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1783557..1784534 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1784506 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1784631..1784638 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1784653..1784672 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1784660 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1784696..1785754 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1784696..1785754 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1785755..1785824 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1785808..1785814 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1785826..1785845 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1785826 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1785874..1786986 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1785874..1786986 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1787005..1787604 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1787005..1787604 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1787542 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1787586 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1787626..1788124) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1787662) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1788096..1788105 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1788108..1788126) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1788117..1788311 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1788117 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1788118..1788137 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1788124) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1788143..1788148) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1788199..1789062) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1788199..1789062) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1788212) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1788268 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1788300) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1788313..1789080 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1789058..1789062 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1789071..1789085 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1789082 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1789101..1789120) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1789114) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1789116..1789309) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1789132..1789138) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1789310..1791085) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1789310..1791085) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1791086..1791216) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1791209..1791411) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1791209..1791411) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1791261) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1791409..1791428) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1791427) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1791429..1791621) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1791441..1791448) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1791650..1792276) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1791650..1792276) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1791666) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1792310..1792329) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1792323) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1792343..1792350) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1792427..1792918) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1792427..1792918) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1792436) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1792930..1792948) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1792942) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1792962..1792968) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1792993..1793325) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1792993..1793325) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1793326..1793616) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1793341..1793346 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1793361..1793379 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1793363 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1793403..1793630 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1793403..1793630 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1793617..1794093) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1793617..1794093) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1793631..1794138 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1794094..1794196) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1794111..1794116 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1794131..1794149 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1794140 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1794160..1794423 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1794160..1794423 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1794176..1794195) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1794196) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1794198..1794723) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1794209..1794213) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1794428..1794661 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1794428..1794661 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1794648 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1794747..1795091) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1794747..1795091) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1794768) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1795092..1795164) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1795160..1795179) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1795164) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1795166..1795269) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1795193..1795198) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1795256..1795271) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1795269) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1795284..1795293) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1795412) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1795448..1795651) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1795448..1795651) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1795672..1795691) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1795690) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1795692..1795758) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1795707..1795714) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1795724..1795731 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1795743 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1795745..1795757) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1795745..1795764 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1795748..1795880 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1795769) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1795881..1797368 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1795881..1797368 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1796324..1796341) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1796330) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1796354..1796362) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1797354 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1797416..1797421 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1797437..1797455 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1797442 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1797469..1799367 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1797469..1799367 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1798412..1798431) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1798420) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1798445..1798454) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1799357..1800202 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1799357..1800202 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1800203..1801709 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1800235..1801572) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1800235..1801572) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1800246) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1801600..1801619) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1801615) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1801617..1802775) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1801634..1801641) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1801693..1801696 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1801711..1801730 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1801711 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1801791..1802756 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1801791..1802756 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1802744 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1802806..1804059) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1802806..1804059) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1802820) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1804075..1806909) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1804075..1806909) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1807004..1807023) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1807019) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1807021..1807137) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1807038..1807045) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1807138..1809054) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1807138..1809054) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1809065..1809979) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1809065..1809979) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1809983..1810002) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1809998) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1810019..1810023) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1810043..1810633) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1810043..1810633) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1810726..1811970) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1810726..1811970) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1810728) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1812033..1812051) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1812046) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1812048..1812268) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1812064..1812071) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1812254..1812272) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1812268) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1812284..1812292) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1812352..1813569) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1812352..1813569) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1812378) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1813602..1813621) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1813610) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1813635..1813642) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1813805..1814428) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1813805..1814428) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1814429..1814579) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1814455..1814461 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1814467 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1814475..1814486 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1814493..1814501 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1814509..1814609 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1814513..1814531 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1814524 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1814562..1814580) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1814569..1814654 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1814569 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1814579) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1814596..1814602) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1814630..1814637 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1814650..1814669 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1814656 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1814694..1816052 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1814694..1816052 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1815036..1815047) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1815041) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1815061..1815067) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1816068..1816916 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1816068..1816916 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1816332..1816351) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1816339) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1816365..1816373) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1816879 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1816911) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1816942..1817607) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1816942..1817607) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1816956) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1817626..1817976) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1817626..1817976) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1817973..1818251) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1817973..1818251) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1818278..1818297) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1818294) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1818312..1818318) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1818327..1819223) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1818327..1819223) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1819065..1819074 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1819085 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1819088..1819107 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1819103..1819321 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1819247..1819266) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1819267) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1819278..1819285) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1819322..1819795 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1819322..1819795 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1819792 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1819830..1820066) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1819830..1820066) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1819838) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1820089..1820108) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1820104) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1820122..1820131) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1820151..1821485) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1820151..1821485) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1821486..1821621) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1821618..1821637) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1821628) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1821652..1821659) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1821717..1821724 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1821739..1821758 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1821742 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1821743..1821849 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1821850..1822239 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1821850..1822239 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1822249 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1822646..1822984) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1822646..1822984) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1823007..1823014 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1823028..1823047 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1823037 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1823041..1823113 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1823072..1823091) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1823075) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1823103..1823109) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1823114..1823722 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1823114..1823722 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1823712 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1823765..1824367) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1823765..1824367) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1824383..1825294) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1824383..1825294) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1825323..1825342) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1825339) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1825358..1825363) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1825415..1825418 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1825433..1825452 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1825435 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1825478..1825678 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1825478..1825678 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1825678..1827168 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1825678..1827168 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1826413..1826424) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1826417) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1826438..1826444) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1827156 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1827203..1828603) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1827203..1828603) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1827227) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1828374..1828383 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1828395..1828410 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1828409 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1828623..1828642) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1828643) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1828656..1828663) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1828702..1828711 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1828717 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1828724..1828743 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1828756..1829457 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1828756..1829457 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1829482..1829490 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1829504..1829523 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1829509 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1829545..1829796 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1829545..1829796 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1829817 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1829867..1830688) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1829867..1830688) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1829893) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1830689..1830770) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1830771..1831472) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1830771..1831472) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1831473..1831562) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1831547..1831566) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1831562) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1831582..1831586) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1831620..1831626 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1831641..1831652 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1831658 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1831674..1831799 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1831674..1831799 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1831797 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1831839..1832153) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1831839..1832153) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1831851) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1832174..1832192) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1832181) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1832203..1832211) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1832214..1832825) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1832214..1832825) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1832903..1833079) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1832903..1833079) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1832907) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1832918) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1832922..1832941) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1832957..1832960) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1833093..1833111) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1833114) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1833116..1833337) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1833127..1833132) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1833137..1833142 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1833157..1833175 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1833159 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1833198..1833341 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1833198..1833341 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1833338..1834018) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1833338..1834018) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1833342..1834353 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1834045..1834064) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1834051) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1834078..1834087) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1834169..1834393) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1834169..1834393) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1834183) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1834434..1834453) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1834446) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1834480..1834758) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1834480..1834758) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1834755..1836170) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1834755..1836170) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1835426..1835429 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1835445..1835464 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1835450 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1836199..1837026) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1836199..1837026) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1837004..1838314) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1837004..1838314) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1838323..1838976) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1838323..1838976) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1838961..1839650) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1838961..1839650) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1839657..1840991) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1839657..1840991) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1840972..1841127) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1840972..1841127) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1841010..1841028) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1841026) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1841044..1841049) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1841121..1841354) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1841121..1841354) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1841128) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1841230..1841234 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1841243..1841257 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1841258 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1841259..1841278) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1841268) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1841293..1841302) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1841314..1842093) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1841314..1842093) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1842122..1843402) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1842122..1843402) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1842770..1842788) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1842786) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1842802..1842809) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1843370..1843388) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1843380) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1843404..1843409) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1843467..1843772) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1843467..1843772) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1843600) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1843796..1843815) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1843811) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1843829..1843838) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1843908..1843917 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1843931..1843950 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1843931 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1843952) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1843954..1843968) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1843977..1843981) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1843977..1844378 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1843977..1844378 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1844385..1845338 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1844385..1845338 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1845328 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1845409..1846557) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1845409..1846557) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1845426) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1846570..1846574 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1846583..1846602) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1846590..1846609 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1846592) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1846600 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1846861..1846869 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1846883..1846902 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1846886 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1846927..1847952 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1846927..1847952 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1847330 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1847332..1847336 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1847346..1847347 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1847944 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1847996..1848427) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1847996..1848427) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1848001) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1848428..1848961) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1848428..1848961) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1848965..1848971 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1848982..1849092 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1848982 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1848984..1849003 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1848989..1849008) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1849009) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1849024..1849025) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1849093..1849518 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1849093..1849518 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1849506 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1849551..1850782 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1849568..1850905) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1849568..1850905) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1850977..1851171) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1850977..1851171) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1850990) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1851184..1851747) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1851184..1851747) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1851757..1852524) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1851757..1852524) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1852548..1852567) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1852565) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1852578..1852585) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1852602..1853183) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1852602..1853183) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1853184..1853299) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1853331..1853582) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1853331..1853582) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1853344) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1853605..1853624) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1853619) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1853668..1854936) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1853668..1854936) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1854970..1854989) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1854989) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1855001..1855008) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1855143..1855162 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1855146 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1855185..1856180 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1855185..1856180 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1856201..1856842 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1856201..1856842 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1856843..1857944 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1856881..1857501) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1856881..1857501) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1856907) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1857502..1858008) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1857502..1858008) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1858005..1858799) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1858005..1858799) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1858883..1859416) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1858883..1859416) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1858888) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1859346..1859351 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1859362..1860308 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1859364 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1859368..1859386 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1859434..1860045) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1859434..1860045) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1860077..1860096) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1860096) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1860109..1860114) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1860265 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1860305..1861078) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1860305..1861078) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1860340) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1861120..1861554) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1861120..1861554) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1861132) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1861583..1861602) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1861594) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1861596..1861660) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1861616..1861623) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1861639) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1861661..1863337) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1861661..1863337) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1863338..1863528) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1863517..1863536) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1863528) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1863551..1863554) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1863626..1864759) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1863626..1864759) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1863642) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1864781..1864800) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1864784) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1864819..1865436) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1864819..1865436) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1865452..1865934) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1865452..1865934) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1865935..1866082) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1866073..1866091) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1866083) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1866102..1866110) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1866136..1866145 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1866158..1866173 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1866160..1866246 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1866160 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1866209..1866216 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1866231..1866250 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1866248 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1866277..1867182 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1866277..1867182 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1867217..1867236 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1867231 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1867232..1867412 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1867413..1868561 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1867413..1868561 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1867582..1868611) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1868557 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1868593..1868612) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1868611) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1868627..1868635) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1868642..1868788 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1868642..1868788 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1868681..1868688 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1868702..1868721 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1868713..1868803 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1868713 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1868804..1869004 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1868804..1869004 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1869019 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1869056..1869238) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1869056..1869238) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1869064..1869369 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1869073) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1869299..1869317) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1869331..1869337) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1869335) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1869345..1869351 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1869366..1869377 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1869371 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1869394..1869663 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1869394..1869663 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1869518 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1869646 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1869691..1869873) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1869691..1869873) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1869711) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1869866..1870546) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1869866..1870546) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1870547..1870684) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1870563..1870568 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1870581..1870600 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1870586 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1870629..1871318 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1870629..1871318 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1870682..1870698) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1870685) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1870686..1871075) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1871056..1871075) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1871073) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1871087..1871095) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1871318..1871716 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1871318..1871716 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1871709..1871715 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1871730..1871741 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1871741 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1871758..1871886 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1871758..1871886 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1871887..1872867 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1871894..1872784) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1871894..1872784) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1871931) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1872806..1872825) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1872813) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1872837..1872843) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1872841 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1872885..1873031) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1872885..1873031) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1872901) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1873055) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1873056..1873067) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1873082..1873088) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1873106..1873363) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1873106..1873363) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1873383..1873402) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873398) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1873414..1873421) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1873428..1877009) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1873428..1877009) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1877010..1877081) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1877071..1877090) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1877081) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1877126..1877323) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1877169) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1877185..1877274) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1877185..1877274) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1877302..1877321) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1877323) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1877336..1877343) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1877345..1877851) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1877345..1877851) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1877855..1878952) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1877855..1878952) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1878970..1878981) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1878973) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1878996..1879002) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1879026..1880342) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1879026..1880342) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1879039) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1880339..1880923) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1880339..1880923) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1881012..1881112) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1881012..1881112) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1881019) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1881113..1881253) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1881254..1882759) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1881254..1882759) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1882695..1882795) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1882735) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1882747 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1882785..1882804) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1882801) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1882818..1882825) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1882871..1883863) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1882871..1883863) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1882889) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1883908..1884498) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1883908..1884498) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1884500..1885474) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1884500..1885474) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1885512..1886531) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1885512..1886531) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1886579..1886598) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1886589) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1886610..1886617) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1886652..1886659 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1886673..1886752 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1886673 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1886674..1886693 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1886753..1887580 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1886753..1887580 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1887582..1888346 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1887582..1888346 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1888335 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1888377) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1888387..1890312) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1888387..1890312) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1890343..1890362) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1890347) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1890349..1890413) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1890377..1890381) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1890414..1890605) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1890414..1890605) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1890624..1890642) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1890633) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1890635..1890940) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1890658..1890663) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1890672..1890678 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1890693..1890704 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1890702 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1890769..1890921 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1890769..1890921 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1890931 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1890974..1892131) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1890974..1892131) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1890985) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1892219..1892619) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1892219..1892619) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1892229) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1892616..1892635) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1892634) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1892650..1892656) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1892678..1892974) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1892678..1892974) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1892999..1893018) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1893009) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1893032..1893039) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1893052..1893681) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1893052..1893681) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1893647) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1893683..1893910) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1893683..1893910) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1893938..1893957) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1893953) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1893955..1894109) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1893971..1893979) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1893994..1894122) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1893994..1894122) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1894109) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1894111..1894222) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1894112..1894131) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1894147..1894151) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1894223..1895464) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1894223..1895464) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1895178..1895196) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1895187) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1895211..1895218) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1895480..1897729) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1895480..1897729) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1897745..1897764) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1897761) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1897778..1897784) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1897832..1898338) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1897832..1898338) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1897855) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1898382..1898401) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1898399) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1898415..1898422) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1898420..1898429 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1898443..1898462 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1898455 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1898476..1898895 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1898476..1898895 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1898896..1899046 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1898916..1899293) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1898916..1899293) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1898949) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1899291..1899436 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1899323..1899341) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1899342) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1899355..1899364) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1899437..1899456 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1899438 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1899481..1899669 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1899481..1899669 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1899685 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1899708..1900079) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1899708..1900079) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1899741) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1900091..1900110) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1900104) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1900123..1900128) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1900125..1900370) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1900125..1900370) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1900396..1900414) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1900401) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1900426..1900434) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1900520..1900526 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1900541..1900552 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1900548 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1900569..1900673 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1900569..1900673 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1900655 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1900698..1901660) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1900698..1901660) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1900828..1900837 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1900849..1900864 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1900849 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1900853..1901188 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1901159..1901163 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1901179..1901198 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1901190..1901700 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1901190 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1901661..1902117) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1901701..1902321 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1901701..1902321 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1902106..1902117) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1902117) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1902132..1902138) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1902343..1905087 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1902343..1905087 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1904757) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1905073 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1905163..1905657) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1905163..1905657) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1905176) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1905654..1906313) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1905654..1906313) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1906332..1907030) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1906332..1907030) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1907031..1907122) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1907123..1908415) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1907123..1908415) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1908416..1908477) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1908477..1908496) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1908477) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1908511..1908518) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1908559..1909740) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1908559..1909740) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1908563) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1909763..1910248) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1909763..1910248) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1910196..1910215) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1910213) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1910228..1910235) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1910257..1910427) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1910257..1910427) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1910428..1910499) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1910461..1910467 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1910482..1910501) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1910482..1910493 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1910489..1910563 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1910489 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1910499) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1910501..1910569) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1910517..1910523) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1910533 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1910570..1913365) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1910570..1913365) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1911038..1911042 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1911039 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1911044..1911048 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1911695..1911710) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1911709) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1911723..1911732) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1913366..1913490) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1913491..1913874) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1913491..1913874) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1913876..1914736) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1913876..1914736) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1914738..1915571) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1914738..1915571) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1915572..1915779) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1915774..1915793) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915779) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1915810..1915814) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1915817..1916794) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1915817..1916794) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1916779..1917972) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1916779..1917972) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1917977..1919110) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1917977..1919110) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1919107..1919817) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1919107..1919817) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1919810..1920223) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1919810..1920223) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1920239..1921042) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1920239..1921042) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1921054..1921389) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1921054..1921389) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1921409..1921428) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1921419) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1921442..1921449) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1921458..1921465 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1921474..1921493) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1921479..1921498 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1921485 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1921493) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1921529..1922401 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1921529..1922401 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1922443..1923237) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1922443..1923237) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1922468) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1923238..1923305) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1923306..1923863) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1923306..1923863) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1923864..1923943) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1923988) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1924010..1924777) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1924010..1924777) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1924812..1925486) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1924812..1925486) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1925488..1925991) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1925488..1925991) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1926000 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1926055..1926074) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1926055) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1926089..1926096) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1926134..1926580) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1926134..1926580) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1926583 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1926635..1927174) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1926635..1927174) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1926648) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1927207..1927225) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1927218) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1927237..1927245) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1927246..1928517) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1927246..1928517) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1928518..1928585) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1928582..1928601) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1928585) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1928615..1928622) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1928652..1928671) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1928658) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1928660..1928804) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1928682..1928689) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1928786..1928804) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1928804) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1928820..1928825) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1928853..1930139) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1928853..1930139) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1928876) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1930150..1931265) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1930150..1931265) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1931314..1932396) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1931314..1932396) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1932407..1933210) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1932407..1933210) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1932895..1932914) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1932912) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1932926..1932933) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1933203..1934405) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1933203..1934405) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1934386..1935033) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1934386..1935033) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1934480) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1934656..1934659) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1934656) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1934876) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1935038..1935790 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1935038..1935790) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1935038..1935790) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1935071..1935073) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1935074 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1935180,1935183) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935194,1935196) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935196,1935198) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935221,1935223) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935223,1935227) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935229,1935231) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935238,1935240) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935253,1935255) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935256,1935258) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935261,1935263) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935271,1935273) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935274,1935276) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935277,1935279) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935283,1935285) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935309,1935311) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935341,1935343) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935394,1935396) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935442,1935444) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935457,1935461) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935475,1935477) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935484,1935486) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935496,1935498) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935561,1935563) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935571,1935573) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935579,1935582) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935599,1935601) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935615,1935617) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935643,1935645) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935658,1935660) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935683,1935685) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935700,1935702) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1935715,1935717) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1935783..1936799) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1935783..1936799) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1936771..1938318) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1936771..1938318) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1938397..1938528) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1938440) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1938519..1938538) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1938528) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1938534..1938917) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1938534..1938917) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1938553..1938560) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1938914..1940002) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1938914..1940002) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1939043..1939058) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1939056) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1939071..1939079) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1940002..1941174) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1940002..1941174) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1941209..1941228) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1941226) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1941241..1941248) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1941249..1942019) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1941249..1942019) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1942045..1942064) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1942062) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1942076..1942082) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1942094..1942255) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1942137) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1942256..1942705) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1942256..1942705) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1942748..1942767) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1942755) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1942780..1942787) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1942821..1943867) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1942821..1943867) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1943809..1944510) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1943809..1944510) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1944517..1945272) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1944517..1945272) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1945273..1945358) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1945347..1945366) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1945358) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1945377..1945384) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1945436..1945663) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1945436..1945663) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1945457) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1945685..1946257) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1945685..1946257) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1946286..1946305) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1946296) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1946298..1946381) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1946318..1946324) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1946426) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1946445..1946723) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1946445..1946723) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1946724..1946949) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1946931..1946950) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1946949) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1946967..1946972) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1947097..1948575) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1947097..1948575) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1947110) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1948576..1948737) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1948724..1948742) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1948749) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1948756..1949490) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1948756..1949490) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1948757..1948762) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1948782) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1949512..1949715) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1949512..1949715) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1949751..1949770) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949772) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1949784..1949791) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1949837..1950036) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1949880) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1950011..1950030) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1950036) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1950044..1950053) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1950053..1951090) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1950053..1951090) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1951108..1952418) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1951108..1952418) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1952419..1952543) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1952529..1952548) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952543) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1952563..1952566) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1952572..1952766) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1952572..1952766) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1952763..1953656) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1952763..1953656) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1953653..1954252) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1953653..1954252) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1954125..1954131 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1954140..1954323 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1954142 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1954145..1954156 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1954263..1954281) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1954282) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1954297..1954302) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1954330..1954461 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1954330..1954461 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1954449 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1954504..1955553) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1954504..1955553) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1954524) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1955428) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1955566..1956714) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1955566..1956714) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1955895..1955898 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1955922 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1955988 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1956692 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1956715..1956854) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1956853..1956872) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1956854) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1956856..1956946) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1956887..1956894) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1956947..1957621) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1956947..1957621) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1957622..1957699) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1957700..1957876) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1957700..1957876) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1957888..1957906) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1957905) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1957921..1957927) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1957921..1958574) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1957921..1958574) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1958604..1958623) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1958617) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1958639..1958643) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1958667..1960019) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1958667..1960019) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1958682) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1960054..1960971) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1960054..1960971) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1960442) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1960593..1960600) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1960596) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1961009..1961020) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961018) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1961034..1961040) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1961110..1961766) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1961110..1961766) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1961124) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1961791..1961810) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1961806) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1961886..1962860) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1961886..1962860) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1961894) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1962714..1962719 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1962735..1962753 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1962745..1962938 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1962745 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1962896 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1962969..1964252) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1962969..1964252) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1962972) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1963010..1963016 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1963028..1963032 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1963028 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1964295..1964314) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1964316) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1964329..1964336) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1964408..1964992) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1964408..1964992) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1964410) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1964993..1965074) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1965067..1965086) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1965074) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1965100..1965107) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1965151..1965930) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1965151..1965930) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1965956..1965971) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1965967) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1965983..1965992) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1966016..1966459) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1966016..1966459) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1966033) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1966522..1967244) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1966522..1967244) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1966803) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1967195..1967764) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1967195..1967764) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1967513..1967531) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1967529) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1967546..1967552) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1967783..1968529 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(1967824..1969314) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(1967824..1969314) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(1969307..1970365) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(1969307..1970365) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 1969655..1969664 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1969675..1970465 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 1969675 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1969677..1969696 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1970406..1970425) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1970429) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1970437..1970444) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1970443..1970449 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 1970463..1970482 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 1970467..1970536 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 1970467 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 1970516..1970523 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1970538..1970630 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 1970538..1970557 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1970538 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 1970631..1970879 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 1970631..1970879 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 1970863 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1970919..1971491) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(1970919..1971491) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(1970939) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1971483..1971790) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(1971483..1971790) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(1971492..1971596) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(1971789..1971808) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1971805) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1971822..1971828) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1971917..1971924 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1971935 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1971939..1971958 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1971988..1973565 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 1971988..1973565 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 1973547 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(1973608..1974375) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(1973608..1974375) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(1973623) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1973877..1974489 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(1974402..1974421) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1974415) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1974436..1974439) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1974449 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(1974487..1975593) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(1974487..1975593) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(1974504) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(1975529..1976113) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(1975529..1976113) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 1975907..1975912 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1975923 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1975927..1975931 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1976064..1976069 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1976081 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1976085..1976103 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1976121 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1976162..1976181) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1976166..1976273 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(1976170) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1976194..1976201) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1976229 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(1976258..1976316) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(1976289) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1976317..1978086) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(1976317..1978086) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(1976373) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(1978083..1978805) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(1978083..1978805) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(1978806..1978885) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(1978886..1980061) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(1978886..1980061) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(1980081..1981709) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(1980081..1981709) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(1981706..1982245) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(1981706..1982245) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(1982246..1982339) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(1982340..1983074) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(1982340..1983074) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(1983083..1983102) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1983106) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1983117..1983121) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1983166..1983702) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(1983166..1983702) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(1983171..1983190) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1983175) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1983205..1983212) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1983707..1984297) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(1983707..1984297) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(1984285..1985433) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(1984285..1985433) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(1985455..1985473) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1985462) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1985488..1985493) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1985556..1986095) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(1985556..1986095) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(1985569) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1986104..1986121) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1986119) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1986136..1986141) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1986150..1986743) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(1986150..1986743) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(1986733..1987488) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(1986733..1987488) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 1987332..1987341 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1987354..1987373 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1987363 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1987534..1987553) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1987549) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1987567..1987574) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1987714..1987721 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1987732..1987751 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1987737 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 1987769..1988293 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 1987769..1988293 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(1988307..1988681) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(1988307..1988681) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(1988323) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1988743..1988762) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1988755) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1988774..1988781) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1988794..1989258) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(1988794..1989258) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 1989129..1989133 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1989147..1989151 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1989150 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1989291..1990487) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(1989291..1990487) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(1990502..1991149) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(1990502..1991149) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(1991160..1992245) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(1991160..1992245) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(1992246..1992374) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(1992375..1992519) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(1992375..1992519) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(1992536..1992555) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1992546) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1992570..1992577) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1992639..1992983) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(1992639..1992983) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(1992654) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1993015..1993033) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1993028) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1993042..1993047 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1993048..1993054) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1993062..1993984 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 1993062 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1993063..1993081 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1993069..1993084) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1993072) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1993074..1993140) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(1993097..1993106) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1993135..1993143) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1993140) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1993157..1993165) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1993218..1993772) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(1993218..1993772) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(1993228) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1993798..1993817) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1993816) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1993818..1994217) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(1993829..1993835) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1994039..1994275 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 1994039..1994275 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(1994218..1994424) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(1994218..1994424) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(1994457..1994476) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1994479) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(1994533..1994787) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(1994533..1994787) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 1994667..1994676 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1994678..1995067) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(1994678..1995067) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 1994690..1995761 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 1994690..1994709 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1994690 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1995045..1995248) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(1995045..1995248) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 1995657..1995773 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 1995657..1995773 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 1995724 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 1995850..1995859 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1995872..1995891 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1995872 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1995914..1996126 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 1995914..1996126 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 1996120 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(1996262) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1996262..1996693) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(1996262..1996693) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(1996694..1996780) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(1996763..1996782) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1996780) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1996796..1996801) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1996830..1996839 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1996849..1996946 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 1996849 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1996852..1996867 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1996947..1997819 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 1996947..1997819 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 1997726 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1997792 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1997849..1999168) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(1997849..1999168) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(1997869) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1999169..1999233) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(1999229..1999248) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999233) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1999263..1999270) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1999274..1999892) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(1999274..1999892) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(1999878,1999885) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 1999879..1999884 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<1999885..1999901) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(1999902..2001071) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(1999902..2001071) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(2001100..2001111) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2001115) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2001125..2001131) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2001217) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2001226..2002041) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(2001226..2002041) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(2002054..2003238) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(2002054..2003238) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(2003287..2003306) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2003305) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2003307..2003398) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2003322..2003329) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2003399..2004289) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(2003399..2004289) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(2004297..2004524) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(2004297..2004524) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(2004427..2004446) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2004438) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2004460..2004467) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2004517) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2004526..2004544) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2004554..2004572) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2004560..2004566) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2004567) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2004589..2004594) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2004649) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(2004649..2005098) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(2004649..2005098) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(2005122..2005141) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2005132) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(2005134..2005210) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2005157..2005161) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2005211..2005855) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(2005211..2005855) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(2005886..2005904) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2005903) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(2005919..2005924) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2005956..2006171) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(2005956..2006171) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(2006036) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2006271..2007590) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(2006271..2007590) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(2006278) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(2007608..2009014) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(2007608..2009014) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(2009062..2009081) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2009071) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2009073..2009154) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2009096..2009103) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2009155..2010582) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(2009155..2010582) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(2010627..2011616) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(2010627..2011616) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(2011617..2011696) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2011678..2011697) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2011696) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2011698..2012018) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2011712..2011719) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2011737..2011744 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2011757..2011776 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2011759 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 2011798..2012148 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 2011798..2012148 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(2012020..2012156) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2012063) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(2012157..2013320) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(2012157..2013320) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(2013317..2013874) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(2013317..2013874) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(2013804..2013904) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2013844) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2013888..2013893 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2013909..2013927 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2013911..2013925) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2013915 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 2013922..2014096 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2013927..2013930) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2013930) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 2013949..2014071 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 2013949..2014071 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 2014072..2014079 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2014093..2014112 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2014098 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 2014134..2015054 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 2014134..2015054 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 2015043 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2015086..2015310) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(2015086..2015310) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(2015143) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2015333..2015352) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2015340) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2015367..2015374) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2015389..2015396 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2015411..2015430 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2015418 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 2015472..2016389 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 2015472..2016389 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 2016364 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(2016429..2016668) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(2016429..2016668) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(2016440) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2016681..2017004) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(2016681..2017004) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(2016747..2016766) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2016748) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2016780..2016787) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2017001..2018032) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(2017001..2018032) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(2017028..2017047) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2017035) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2017058..2017065) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2018025..2018369) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(2018025..2018369) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(2018379..2018849) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(2018379..2018849) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(2018850..2018926) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2018850 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2018901..2018920) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2018926) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2018928..2019034) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2018935..2018942) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2019035..2019373) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(2019035..2019373) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(2019370..2020608) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(2019370..2020608) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 2019532..2019533 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2019543 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2019598 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2020633..2020651) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2020642) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(2020668..2020673) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2020713..2020716 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2020731..2020750 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2020740 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 2020774..2020980 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 2020774..2020980 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 2021463..2021466 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2021481..2021500 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2021497 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 2021529..2022761 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 2021529..2022761 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 2022608..2022970 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 2022608..2022970 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(2022787..2022966) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2022820) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2022967..2023353) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(2022967..2023353) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(2023357..2024316) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(2023357..2024316) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(2024317..2024387) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2024388..2025734) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(2024388..2025734) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(2025735..2025809) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2025810..2026589) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(2025810..2026589) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(2026595..2027554) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(2026595..2027554) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(2027576..2027595) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2027595) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2027610..2027617) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2027651..2027658 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2027672..2027958 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2027672 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2027674..2027693 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2027688..2027933 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 2027688..2027933 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 2027959..2028795 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 2027959..2028795 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 2028793 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2028836..2030479) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(2028836..2030479) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(2028848) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2030497..2030503 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2030510 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2030517..2030528 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2030535..2030554) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2030540) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2030586..2030593 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2030607..2030626 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2030609 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2030651..2031667 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 2030651..2031667 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 2031654 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 2031716..2031725 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2031738..2031753 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2031742 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2031777..2032538 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 2031777..2032538 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 2032446 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2032534 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2032566..2032766) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2032582..2032707) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(2032582..2032707) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(2032609) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2032700..2032732) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(2032700..2032732) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(2032760..2032779) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2032766) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2032792..2032799) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2032814..2033737) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(2032814..2033737) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2033763..2033782) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2033776) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2033796..2033801) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2033875..2033882 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2033896..2033915 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2033898..2033963 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2033898 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2033964..2035433 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2033964..2035433 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2035416 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2035441..2035480 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2035453,2035456) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2035461,2035462) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2035473,2035474) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2035482 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2035556..2036965) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2035556..2036965) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2035573) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2035646) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2037029..2037047) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2037031) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2037075..2038319) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2037075..2038319) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2038320..2038594) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2038340..2038347 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2038361..2038380 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2038361 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2038392..2038679 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2038392..2038679 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2038576..2038595) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2038596) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2038611..2038614) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2038710..2039537 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2038710..2039537 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2039354 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2039530 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2039542..2040462) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2039585) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2039655..2039661 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2039675..2039693 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2039684 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2039717..2040445 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2039717..2040445 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2040486..2041601) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2040486..2041601) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2040507) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2041619..2043142) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2041619..2043142) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2042725..2042744) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2042747) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2042759..2042763) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2043135..2043557) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2043135..2043557) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2043586..2043593 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2043607..2043626 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2043621..2043774 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2043621 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2043731 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2043759..2044289) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2043759..2044289) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2043776..2044411 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2044306..2044317) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2044313) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2044332..2044338) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2044341..2045309) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2044341..2045309) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2044357) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2045380..2046102) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2045380..2046102) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2045391) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2046095..2046754) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2046095..2046754) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2046755..2046834) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2046835..2047602) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2046835..2047602) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2047652..2047671) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2047667) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2047686..2047693) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2047870..2048307) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2047870..2048307) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2047879) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2048331..2048350) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2048352) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2048365..2048372) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2048405..2048411 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2048424 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2048426..2048444 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2048468..2049361 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2048468..2049361 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2049394..2049401 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2049417..2049436 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2049425 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2049462..2050631 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2049462..2050631 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2050614 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2050704..2051540 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2050704..2051540 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2051538 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2051602) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2051602..2052876) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2051602..2052876) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2052899..2053882) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2052899..2053882) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2053896..2054888) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2053896..2054888) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2054910..2056334) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2054910..2056334) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2056355..2057446) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2056355..2057446) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2057465..2058559) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2057465..2058559) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2058571..2059470) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2058571..2059470) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2059506..2059525) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2059511) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2059513..2059594) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2059595..2061673) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2059595..2061673) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2061733..2061752) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2061750) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2061760..2061767 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2061769..2061772) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2061781..2061800 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2061788 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2061826..2062062 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2061826..2062062 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2062053 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2062104..2063009) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2062104..2063009) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2062107) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2063027..2064445) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2063027..2064445) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2063322..2063341) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2063339) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2064460..2065578) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2064460..2065578) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2065612..2066751) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2065612..2066751) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2066779..2067642) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2066779..2067642) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2067667..2068848) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2067667..2068848) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2068428) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2068535..2068541) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2068538) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2068762..2068862) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2068802) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2068895..2068913) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2068913) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2068929..2068934) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2068975..2069706) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2068975..2069706) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2068982) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2069729..2069748) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2069740) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2069763..2069766) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2069785..2070405) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2069785..2070405) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2070420..2070713) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2070420..2070713) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2070733..2070752) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2070739) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2070767..2070774) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2070969..2070976 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2070990..2071009 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2071007..2071212 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2071007 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2071021..2071173 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2071021..2071173 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2071181..2071188 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2071203..2071222 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2071214 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2071246..2072364 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2071246..2072364 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2072349 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2072391..2072561) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2072434) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2072545..2072560) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2072561) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2072563..2072691) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2072572..2072581) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2072690..2072709) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2072713) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2072723..2072731) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2072823) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2072829..2073632) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2072829..2073632) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2073675..2073693) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2073681) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2073683..2073835) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2073704..2073712) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2073831..2073850) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2073843) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2073862..2073869) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 2073877..2073878 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_005" CDS complement(2073938..2075668) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2073938..2075668) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2073953) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2075705..2076154) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2075705..2076154) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2076155..2076240) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2076252..2077097) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2076252..2077097) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2076285) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2077094..2078995) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2077094..2078995) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2078203..2078209 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2078224..2078235 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2078232 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2078996..2079124) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2079119..2079138) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2079124) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2079153..2079159) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2079170..2080060) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2079170..2080060) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2080050..2080304) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2080050..2080304) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2080301..2081647) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2080301..2081647) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2081648..2081784) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2081785..2082636) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2081785..2082636) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2082648..2083043) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2082648..2083043) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2083086..2083105) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2083105) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2083107..2083269) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2083307..2083714) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2083307..2083714) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2083314) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2083735..2085087) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2083735..2085087) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2084616..2084635) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2084623) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2084650..2084656) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2085099..2085578) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2085099..2085578) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2085637..2085656) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085648) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2085670..2085677) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2085734..2086390) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2085734..2086390) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2085741) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2086391..2087080) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2086391..2087080) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2087073..2087693) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2087073..2087693) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2087399..2087417) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2087417) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2087433..2087438) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2087707..2088906) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2087707..2088906) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2088925..2089326) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2088925..2089326) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2089333..2089539) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2089333..2089539) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2089562..2090077) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2089562..2090077) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2090071..2090994) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2090071..2090994) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2090995..2091069) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2091070..2091351) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2091070..2091351) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2091371..2091389) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2091394) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2091405..2091410) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2091496..2092053) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2091496..2092053) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2091508) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2092078..2093139) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2092078..2093139) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2093136..2093582) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2093136..2093582) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2093631..2093650) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093647) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2093663..2093670) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2093669..2094205) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2093669..2094205) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2094218..2094229) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2094227) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2094243..2094249) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2094275..2094281 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2094294 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2094296..2094314 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2094351..2094354 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2094369..2094388 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2094380 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2094432..2095388 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2094432..2095388 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2095428..2095823 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2095428..2095823 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2095706..2095806 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2095766 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2095809 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2095820..2096695) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2095820..2096695) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2096722..2096740) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2096739) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2096756..2096761) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2096821..2097249) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2096821..2097249) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2096848) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2097284..2097303) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2097292) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2097319..2097323) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2097349..2098185) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2097349..2098185) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2098209..2098228) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2098220) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2098222..2098766) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2098242..2098249) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2098266..2098271 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2098285..2098304 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2098285 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2098296..2098375 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2098376..2098756 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2098376..2098756 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2098692 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2098736 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2098791..2100257) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2098791..2100257) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2098811) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2100250..2101596) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2100250..2101596) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2101626..2102714) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2101626..2102714) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2102788..2102987) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2102788..2102987) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2102838) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2102988..2103058) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2102991..2102996 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2103012..2103030 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2103016 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2103026..2103155 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2103044..2103063) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2103058) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2103077..2103084) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2103156..2104829 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2103156..2104829 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2104850..2105644 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2104850..2105644 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2105180..2105181 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2105186 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2105668..2105671 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2105687..2105706 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2105688..2105826 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2105688 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2105827..2106000 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2105827..2106000 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2105985..2105989 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2106002..2106021 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2106002 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2106034..2106369 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2106034..2106369 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2106346 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2106436 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(2106468) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2106485,2106492) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 2106486..2106491 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 2106561..2106567 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2106568 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2106581..2106592 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2106611..2106937 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2106611..2106937 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2106754..2106978) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2106797) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2106919 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2106979..2107158) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2106979..2107158) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2107177..2107195) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2107192) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2107210..2107216) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2107229..2107603) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2107229..2107603) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2107604..2107987) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2107604..2107987) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2108013..2108360) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2108013..2108360) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2108344..2108775) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2108344..2108775) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2108765..2109061) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2108765..2109061) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2109075..2110046) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2109075..2110046) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2110099..2111169) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2110099..2111169) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2111187..2111206) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2111203) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2111220..2111227) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2111352..2111580) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2111393) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2111581..2112534) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2111581..2112534) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2112558..2112577) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2112579) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2112591..2112597) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2112617..2112623 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2112638..2112656 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2112656 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2112677..2114005 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2112677..2114005 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2114006..2114980 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2114058..2114894) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2114058..2114894) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2114895..2115079) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2114981..2115051 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2114981..2115051 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2115118..2115498) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2115118..2115498) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2115124) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2115527..2115545) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2115546) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2115560..2115566) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2115585..2115590 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2115606..2115624 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2115615 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2115665..2115672 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2115687 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2115688..2115707 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2115730..2115975 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2115730..2115975 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2115872 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2115961 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2116006..2116761 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2116015..2116650) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2116015..2116650) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2116040) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2116672..2116691) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2116689) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2116705..2116712) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2116729..2116736 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2116751..2116770 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2116763 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2116783) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2116785..2116799) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2116807..2116811) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2116807..2116980 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2116807..2116980 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2116968 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2117012..2117326) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2117012..2117326) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2117013..2118080 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2117026) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2117329..2118390) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2117329..2118390) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2118452..2119582) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2118452..2119582) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2119590..2119608) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119622) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119624..2119629) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2119665..2121581) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2119665..2121581) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2119692) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2120697..2120703 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2120716..2121745 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2120716 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2120719..2120737 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2121582..2121648) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2121642..2121661) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2121648) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2121676..2121683) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2121698..2122663) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2121698..2122663) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2122674..2122889) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2122674..2122889) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2122890..2122998) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2122999..2124522) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2122999..2124522) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2124540..2124559) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2124553) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2124574..2124581) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2124612..2124785) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2124612..2124785) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2124639) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2124801..2124812) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2124813) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2124826..2124832) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2124852..2125415) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2124852..2125415) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2125416..2125499) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2125500..2125649) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2125500..2125649) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2125546) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2125686..2125705) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2125696) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2125721..2125724) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2125733..2126812) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2125733..2126812) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2126809..2127279) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2126809..2127279) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2127224..2127232 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2127246..2127254 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2127247..2127420 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2127248 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2127315..2127334) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2127327) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2127346..2127353) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2127392..2127396 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2127412..2127431 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2127422 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2127459..2127812 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2127459..2127812 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2127809..2128273 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2127809..2128273 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2128259 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2128302..2129084) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2128302..2129084) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2128313) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2129095..2129904) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2129095..2129904) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2129925..2130809) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2129925..2130809) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2130809..2131738) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2130809..2131738) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2131807..2132709) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2131807..2132709) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2132764) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2132772..2132788) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2132799..2132801) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2132818,2132820) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2132864..2135014) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2132864..2135014) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2132874) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2133608..2133626) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2133616) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2133642..2133648) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2134303..2134322) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2134320) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2134336..2134345) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2135064..2135083) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2135069) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2135099..2135103) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2135128..2136420) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2135128..2136420) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2136443..2136454) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2136454) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2136468..2136474) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2136527..2137135) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2136527..2137135) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2136542) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2137187..2137206) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2137198) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2137200..2137268) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2137221..2137228) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2137259..2137277) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2137268) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2137292..2137298) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2137314..2137796) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2137314..2137796) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2137797..2138089) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2137839..2137845 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2137860..2137879 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2137873 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2137906..2138673 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2137906..2138673 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2138087..2138105) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2138089) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2138091..2139027) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2138119..2138125) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2138674..2139104 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2139061 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2139072) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2139089..2139517) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2139089..2139517) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2139513..2139517 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2139527..2139541 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2139536 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2139540..2139559) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2139563) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2139574..2139581) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2139732..2139737 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2139753..2139771 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2139765 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2139794..2140093 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2139794..2140093 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2140106..2140113 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2140128..2140147 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2140139..2140215 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2140139 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2140216..2141349 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2140216..2141349 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2141330 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2141375..2141764) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2141375..2141764) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2141401) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2141795..2141806) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2141799) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2141820..2141826) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2141839..2141846 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2141857..2141876 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2141858 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2141897..2142478 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2141897..2142478 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2142476 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2142521..2143129 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2142521..2142958) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2142521..2142958) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2142525) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2142959..2143053) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2143049..2143068) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2143053) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2143083..2143090) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2143096..2143977) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2143096..2143977) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2143973..2143978 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2143994..2144012 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2144010 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2144015..2144034) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2144021) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2144023..2144350) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2144039..2144048 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2144055 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2144061..2144080 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2144093..2144347 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2144093..2144347 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2144334 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2144374..2145267) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2144374..2145267) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2144379..2145180 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2144395) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2145277..2146593) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2145277..2146593) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2146629..2146648) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146640) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146664..2146668) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2146697..2146706 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2146718 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2146720..2146739 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2146762..2147505 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2146762..2147505 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2147487 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2147509..2147516 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2147530..2147549 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2147532..2147627 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2147532 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2147628..2148572 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2147628..2148572 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2148543 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2148595..2149716) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2148595..2149716) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2148620) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2149709..2150359) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2149709..2150359) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2150360..2150468) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2150456..2150475) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2150468) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2150470..2150583) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2150491..2150495) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2150616..2150978) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2150616..2150978) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2150628) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2150974..2150978 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2150986..2151000 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2151007 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2151015..2151034) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2151017) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2151019..2151140) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2151046..2151053) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2151129..2151148) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2151137..2151156 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2151140) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2151142..2151281) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2151143..2151247 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2151143 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2151162..2151168) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2151211..2151218 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2151232..2151251 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2151249..2153398 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2151249 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2151307..2152422) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2151307..2152422) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2151326) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2152423..2152620) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2152621..2154432) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2152621..2154432) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2154027..2154033 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2154043 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2154045..2154064 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2154072..2154368 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2154072..2154368 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2154466..2154960) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2154466..2154960) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2154933..2154951) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2154944) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2154961..2155074) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2154963..2154971) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2154969..2154974 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2154990..2155008 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2155005 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2155059..2155077) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2155074) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2155076..2155153) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2155093..2155098) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2155119..2155138) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2155153) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2155154..2155157) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2155214..2156026) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2155214..2156026) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2156052..2156690) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2156052..2156690) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2156691..2156822) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2156816..2156835) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2156823..2158862) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2156823..2158862) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2156825) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2156850..2156857) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2156869) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2156935) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2158855..2159742) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2158855..2159742) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2159825..2159999) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2159825..2159999) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2159859) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2159974..2159979 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2159995..2160013 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2160003..2160022) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2160005..2161417 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2160005 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2160015) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2160037..2160044) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2160039..2160806) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2160039..2160806) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2160843..2160986) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2160843..2160986) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2160987..2161133) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2161134..2162039) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2161134..2162039) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2162020..2162430) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2162020..2162430) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2162468..2162487) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2162479) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2162481..2162548) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2162502..2162505) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2162549..2162920) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2162549..2162920) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2162901..2163374) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2162901..2163374) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2163375..2165510) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2163375..2165510) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2165354..2165359 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2165374 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2165375..2165393 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2165589..2166548) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2165589..2166548) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2165604) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2166545..2167741) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2166545..2167741) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2166612..2166631) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2166617) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2166645..2166652) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2166692..2166710) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2166704) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2166725..2166731) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2166919) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2166933..2166944) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2166959..2166965) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2167760..2168041) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2167760..2168041) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2168098..2168517) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2168098..2168517) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2168112) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2168542..2169537) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2168542..2169537) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2169559..2170872) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2169559..2170872) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2170908..2170923) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2170925) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2170936..2170945) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2171003..2171449) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2171003..2171449) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2171016) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2171214) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2171464..2171637) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2171464..2171637) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2171573..2171577 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2171578 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2171698..2171717) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2171713) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2171731..2171738) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2171756..2171761 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2171776 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2171777..2171795 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2171810..2172733 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2171810..2172733 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2172770..2174125) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2172770..2174125) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2172776) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2174125..2174895) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2174125..2174895) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2174918..2175853) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2174918..2175853) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2175878..2177005) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2175878..2177005) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2176922..2176925 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2176933 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2177006..2177183) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2177045..2177135 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2177045..2177135 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2177205..2179040) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2177205..2179040) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2177228) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2179064..2179627) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2179064..2179627) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2179628..2179698) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2179699..2180730) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2179699..2180730) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2180771..2180790) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2180784) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2180805..2180812) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2180811..2181950) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2180811..2181950) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2181823..2181834) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2181827) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2181848..2181854) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2182003..2183841) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2182003..2183841) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2182025) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2183876..2183895) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2183893) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2183911..2183915) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2183975..2184313) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2183975..2184313) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2183981) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2184330..2185535) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2184330..2185535) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2185555..2185573) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2185567) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2185589..2185594) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2185598..2186704) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2185598..2186704) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2186732..2186743) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2186739) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2186758..2186764) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2186803..2186806 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2186819 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2186822..2186841 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2186833..2186907 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2186908..2187174 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2186908..2187174 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2187163 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2187189..2188232) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2187189..2188232) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2187234) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2188261..2188280) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2188272..2188421) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2188272..2188421) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2188273) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2188294..2188298) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2188296..2188635) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2188339) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2188408..2188414 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2188428..2188447 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2188429 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2188462..2188596 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2188462..2188596 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2188590 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2188636..2190966) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2188636..2190966) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2188653..2188672) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2188669) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2188686..2188695) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2190970..2191539) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2190970..2191539) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2191566..2191585) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2191576) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2191600..2191607) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2191606..2192223) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2191606..2192223) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2192244..2192249 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2192261 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2192265..2192283 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2192284..2192298) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2192286) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2192288..2193135) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2192307..2192311) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2192307..2193128 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2192307..2193128 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2193123..2193142) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2193129..2193209 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2193136) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2193156..2193163) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2193169 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2193194..2193937) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2193194..2193937) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2193224) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2193934..2194290) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2193934..2194290) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2194308..2194868) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2194308..2194868) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2194858..2195427) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2194858..2195427) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2195439..2195729) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2195439..2195729) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2195723..2196565) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2195723..2196565) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2196557 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2196583..2197683) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2196583..2197683) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2197687..2198205) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2197687..2198205) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2198115..2198132) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198129) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2198148..2198151) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2198206..2198767) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2198239) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2198430..2198437 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2198448..2198548 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2198448..2198467 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2198448 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2198498..2198756) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2198498..2198756) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2198549..2198707 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2198549..2198707 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2198708..2198954 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2198755..2198774) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198766) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2198790..2198794) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2198818..2198965) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2198855) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2198911 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2198956..>2199033 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2198960..2198979) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198965) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2198992..2199001) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2199033,2199035) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" N_region 2199034 /note="inserted C residue" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" S_feature <2199035..2199477 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" CDS complement(2199048..2199464) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2199048..2199464) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2199510..2200808) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2199510..2200808) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2200795..2201490) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2200795..2201490) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2201556..2201573) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2201565) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2201651..2201657 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2201664..2201682 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2201679 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2201758..2202975 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2201758..2202975 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2202217..2202224 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2202239..2202258 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2202255 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2202894..2203142 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2202894..2203142 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2203071..2204118) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2203487..2204044 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2203487..2204044 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2204045..2204167 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2204120..2204534) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2204163) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2204535..2205059) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2204535..2205059) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2204907..2204914 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2204925..2204944 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2204939 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2205060..2205147) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2205142..2205161) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2205147) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2205149..>2205285) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2205176..2205183) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2205285,2205292) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2205286..2205291 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2205344..2205874) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2205344..2205874) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2205920..2205939) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2205943) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2205953..2205960) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2206009..2206989 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2206009..2206989 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2207263..2208579) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2207263..2208579) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2208580..2208693) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2208694..2209563) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2208694..2209563) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2209586..2209605) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2209603) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2209620..2209625) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2209670..2209671) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2209678) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2209708..2209709) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2209708..2210811 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2209708..2210811 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2210701..2210720 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2210707 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2211058) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2211084..2211917) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2211084..2211917) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2211947..2211966) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2211956) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2212122..2212126 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2212137..2212359 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2212137 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2212141..2212160 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2212360..2212623 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2212360..2212623 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2212611 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2212760..2213575 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2212760..2213575 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2213910..2213982) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2213953) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2213983..2214339) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2213983..2214339) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2214392..2214751) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2214392..2214751) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2214844..2214863) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2214854) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2215023..2215124) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2215023..2215124) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2215164..2215266) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2215206) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2215267..2215653) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2215267..2215653) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2215695..2215711) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2215711) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2215844..2215850 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2215865..2215876 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2215865 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2215902..2216147 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2215902..2216147 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2216165..2216533 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2216165..2216533 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2216552..2217688 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2216552..2217688 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2217707..2217904 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2217707..2217904 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2217920..2218219 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2217920..2218219 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2218210 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2218482..2218904) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2218482..2218904) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2218902..2218905 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2218921..2218940 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2218936..2219086 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2218936 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2218939..2218958) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2218946) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2218972..2218979) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2219055..2219074) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2219063) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2219087..2219281 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2219087..2219281 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2219089..2219096) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2219299..2219306 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2219322..2219341 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2219326 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2219327..2219411 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2219412..2220461 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2219412..2220461 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2220529..2220536 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2220551..2220570 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2220564 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2220592..2221101 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2220592..2221101 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2221070 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2221115..2222220 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2221143..2223176) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2221143..2223176) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2221168) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2223085..2223252) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2223085..2223252) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2223177..2223332) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2223333..2224160) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2223333..2224160) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2224181..2224990) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2224181..2224990) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2225007..2225495) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2225007..2225495) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2225495..2225935) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2225495..2225935) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2225932 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2225972..2225990) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2225976) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2226125..2228932) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2226125..2228932) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2229148..2229167) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2229154) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2229479..2229619 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2229479..2229619 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2229600..2229619 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2229610 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2229658..2231046 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2229658..2231046 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2231035 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2231068..2231141) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2231110) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2231142..2231774) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2231142..2231774) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2231198) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2231828..2231847) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231839) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2231853..2231859 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2231862..2231869) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2231873..2231892 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2231878 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2231927..2232754 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2231927..2232754 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2232750 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2232867..2232876 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2232889..2232904 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2232894 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2232950..2233450 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2232950..2233450 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2233450..2234307 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2233450..2234307 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2234325..2234336) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2234344) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2234351..2234357) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2234418..2236322 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2234418..2236322 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2236403..2236409 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2236425..2236443 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2236431 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2236456..2236746 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2236456..2236746 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2236747..2236862 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2236844..2236851 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2236864..2236989 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2236864 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2236865..2236883 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2236883..2236983 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2236883..2236983 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2236946 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2236990..2240154) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2236990..2240154) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2237006) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2238140..2238149 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2238163..2238182 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2238184 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2240170..2240754) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2240170..2240754) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2240977..2241519) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2240977..2241519) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2241520..2241605) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2241603..2241618) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2241605) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2241631..2241640) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2241674..2241890) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2241708..2241866) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2241708..2241866) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2241717) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2241888..2241907) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2241890) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2241892..2242022) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2241921..2241930) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2242023..2242172) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2242023..2242172) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2242166 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2242173..2242263) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2242265..2242484) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2242308) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2242430 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2242463..2242482) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2242484) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2242486..2242561) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2242497..2242504) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2242562..2243362) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2242562..2243362) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2243431..2243584) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2243474) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2243575..2243594) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2243584) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2243609..2243615) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2243625..2243993) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2243625..2243993) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2243994..2244090) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2244076..2244095) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2244080..2244083 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2244096) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2244099..2244118 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2244101 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2244102..2244308 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2244111..2244115) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2244309..2247251 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2244309..2247251 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2247270..2247752 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2247270..2247752 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2247732 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2247788..2248018) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2247788..2248018) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2247808) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2248019..2248100) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2248101..2249240) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2248101..2249240) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2249242..2250165) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2249242..2250165) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2250158) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2250166..2250229) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2250230..2250925) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2250230..2250925) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2250665..2250684) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2250683) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2250697..2250706) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2250946..2251587) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2250946..2251587) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2251154..2251173) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2251173) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2251190..2251193) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2251639..2251648 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2251645..2251664) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2251651) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2251661..2251680 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2251670..2251734 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2251670 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2251680..2251683) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2251715..2251722 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2251736 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2251738..2251755 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2251780..2251983 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2251780..2251983 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2251990 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2252020..2252721) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2252020..2252721) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2252032) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2252786..2254540) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2252786..2254540) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2252814..2252833) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2252824) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2253855..2253870) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2253858) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2253883..2253892) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2254086..2254104) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2254100) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2254119..2254126 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2254119..2254124) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2254141..2254160 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2254146 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2254594..2255067) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2254594..2255067) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2254601) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2255068..2255200) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2255182..2255201) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255200) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2255202..2255310) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2255215..2255222) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2255303..2255322) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255310) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2255318..2255953) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2255318..2255953) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2255338..2255342) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2255448..2255453 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2255469..2255487 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2255476 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2255960..2257228) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2255960..2257228) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2257247..2258176) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2257247..2258176) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2258182..2258835) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2258182..2258835) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2258836..2258940) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2258922..2258941) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2258940) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2258957..2258961) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2258987..2260069) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2258987..2260069) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2259021) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2260085..2260104) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2260105) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2260119..2260122) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2260195) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2260200..2260481) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2260200..2260481) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2260260) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2260499..2260915) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2260499..2260915) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2260747..2260765) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2260766) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2260781..2260786) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2260923..2261189) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2260923..2261189) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2261077..2261085 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2261100..2261119 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2261108..2262297 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2261108 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2261190..2261250) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2261244..2261263) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2261250) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2261274..2263910) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2261274..2263910) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2261277..2261284) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2263676..2263694) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2263692) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2263708..2263715) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2263911..2263989) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2263990..2264197) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2263990..2264197) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2264205..2264224) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2264220) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2264239..2264246) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2264241..2265302) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2264241..2265302) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2265211..2265216 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2265222..2265457 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2265223 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2265232..2265250 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2265319..2265330) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2265320) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2265344..2265350) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2265458..2266186 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2265458..2266186 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2265914) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2266208..2267029 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2266208..2267029 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2267090..2267740 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2267090..2267740 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2267757..2268413 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2267757..2268413 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2268412 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2268448..2268579) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2268448..2268579) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2268466) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2268601..2268792) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2268601..2268792) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2268804..2269328) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2268804..2269328) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2268915) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2268919..2268930) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2268945..2268951) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2269299..2269310) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2269305) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2269325..2269331) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2269386..2271782) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2269386..2271782) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2269412) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2269632..2269638 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2269646 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2269653..2269664 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2269666..2270015 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2269767) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2271807..2272427) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2271807..2272427) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2272513..2273628) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2272513..2273628) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2272514) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2273659..2274798) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2273659..2274798) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2274365..2274384) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2274377) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2274398..2274405) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2274817..2275233) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2274817..2275233) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2275234..2275331) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2275316..2275335) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2275331) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2275351..2275354) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2275379..2275386 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2275400..2275419 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2275408 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2275436..2276701 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2275436..2276701 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2276700 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2276743..2277507) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2276743..2277507) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2276761) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2277591..2277791) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2277591..2277791) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2277609) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2277778 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2277779..2277788 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2277789..2277808) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2277800) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2277821..2277828) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2277843..2279621) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2277843..2279621) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2279635..2280909) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2279635..2280909) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2280999..2281231) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2280999..2281231) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2281029) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2281241..2281244 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2281255..2281274) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2281259..2281278 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2281261..2281545 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2281261 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2281274) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2281289..2281296) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2281291..2281461) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2281291..2281461) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2281492..2281503) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2281509) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2281518..2281524) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2281521..2281528 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2281542..2281560 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2281547 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2281594..2283150 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2281594..2283150 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2283129 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2283177..2283575) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2283177..2283575) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2283185) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2283629..2285833) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2283629..2285833) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2285862..2285881) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2285869) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2285871..2285961) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2285896..2285903) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2285925 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2286001..2286513) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2286001..2286513) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2286006) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2286519..2288879) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2286519..2288879) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2286983..2287002) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2286991) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2287016..2287025) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2288893..2288912) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288904) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2288927..2288933) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2288946..2289269) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2288946..2289269) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2289290..2289308) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2289301) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2289323..2289329) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2289345..2289842) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2289345..2289842) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2289843..2289918) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2289912..2289931) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2289918) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2289945..2289952) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2290000..2292213) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2290000..2292213) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2290005) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2291772..2291777 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2291791..2291810 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2291799 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2292252..2292548) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2292252..2292548) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2292459 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2292549..2292627) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2292589..2292594 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2292611..2292629 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2292613..2292632) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2292613 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2292627) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2292629..2293547) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2292647..2292650) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2292664..2294220 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2292664..2294220 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2293533..2293551) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2293547) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2293563..2293571) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2294221..2294985 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2294224..2294880) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2294224..2294880) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2294899..2294910) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294911) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2294924..2294930) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2294963..2294968 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2294984..2295002 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2294987 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2295015..2295467 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2295015..2295467 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2295451 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2295506) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2295524..2295790) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2295524..2295790) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2295827..2296972) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2295827..2296972) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2295879) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2295923) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2295925..2295944) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2295959..2295964) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2296999..2298027) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2296999..2298027) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2298057..2298257) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2298057..2298257) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2298250..2299254) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2298250..2299254) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2299265..2299870) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2299265..2299870) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2299889..2299908) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2299905) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2299907..2300008) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2299919..2299925) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2300009..2300521) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2300009..2300521) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2300550..2300561) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2300565) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2300569..2301876) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2300569..2301876) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2300576..2300582) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2301830) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2301900..2301918) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2301915) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2301933..2301939) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2301947..2302972) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2301947..2302972) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2303009..2303028) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2303029) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2303043..2303050) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2303098..2303105 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2303119..2303138 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2303127 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2303159..2303164 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2303173 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2303180..2303198 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2303210..2303857 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2303210..2303857 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2303532..2303865) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2303836 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2303867..2304064) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2303903..2304025) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2303903..2304025) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2303910) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2304073) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2304074..2304091) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2304098..2304105) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2304110..2304400 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2304110..2304400 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2304121..2304140 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2304121..2304268 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2304121 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2304407..2304547 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2304407..2304547 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2304536 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2304596..2304602 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2304610..2304710 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2304617..2304635 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2304618 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2304670 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2304711..2306165 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2304711..2306165 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2306166 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2306206..2306928) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2306206..2306928) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2306211..2306632 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2306222) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2306951..2306970) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2306968) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2306984..2306991) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2307031..2307627) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2307031..2307627) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2307046) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2307670..2307681) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2307672) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2307674..2307738) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2307696..2307702) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2307775..2308938) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2307775..2308938) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2307783) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2308939..2309014) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2308990..2309008) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2309014) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2309024..2309029) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2309055..2310161) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2309055..2310161) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2309737..2309755) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2309762) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2309771..2309776) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2310073 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2310074..2310077 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2310148..2311017) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2310148..2311017) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2310242 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2310971..2312566) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2310971..2312566) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2312594..2312601 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2312594..2312613) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2312615 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2312617..2312636 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2312618) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2312628..2312635) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2312669..2313856 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2312669..2313856 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2312670..2312689) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2312688) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2312704..2312713) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2313571..2313576 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2313585 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2313587..2313606 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2313816..2314358 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2313816..2314358 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2314341 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2314383..2315240) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2314383..2315240) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2314386..2315095 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2314403) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2315257..2315700) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2315257..2315700) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2315761..2317047) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2315761..2317047) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2317081..2317659) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2317081..2317659) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2317660..2317725) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2317710..2317729) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2317725) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2317727..2317944) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2317737..2317859 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2317737..2317859 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2317743..2317750) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2317980..2318264) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2317980..2318264) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2317989) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2318277..2318615) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2318277..2318615) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2318618..2318926) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2318618..2318926) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2318940..2319015) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2318940..2319015) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2319027..2319046) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2319047) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2319060..2319067) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2319073..2319939) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2319073..2319939) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2319932..2320726) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2319932..2320726) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2320729 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2320735..2320835 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2320750..2320768) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2320761) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2320784..2320789) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2320795 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2320838 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2320873) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2320876..2321682) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2320876..2321682) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2321684..2322364) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2321684..2322364) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2322417..2322935) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2322417..2322935) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2322932..2323804) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2322932..2323804) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2323835..2324848) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2323835..2324848) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2324889) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2324901..2324919) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2324940..2325635) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2324940..2325635) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2325672..2326241) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2325672..2326241) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2326093..2326108) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2326102) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2326121..2326130) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2326280..2326299) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2326296) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2326313..2326319) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2326392) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2326394..2327392) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2326394..2327392) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2327439..2327458) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2327447) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2327470..2327477) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2327515) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2327526..2328272) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2327526..2328272) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2328300..2328319) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2328307) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2328334..2328341) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2328412..2329704) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2328412..2329704) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2328417) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2329705..2329763) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2329764..2332406) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2329764..2332406) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2332407..2332465) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2332466..2332688) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2332466..2332688) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2332509) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2332717..2332736) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2332729) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2332731..2332839) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2332751..2332756) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2332793..2332802 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2332815..2332834 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2332816 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2332832..2332846) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2332839) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2332854..2332858) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2332854..2333045 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2332854..2333045 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2333064..2334089) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2333064..2334089) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2333094) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2334122..2335849) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2334122..2335849) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2335451..2335454 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2335470..2335489 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2335476 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2335845..2335849 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2335858..2335872 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2335872 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2335887..2335905) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2335903) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2335921..2335926) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2335980..2337272) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2335980..2337272) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2335997) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2337302..2338276) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2337302..2338276) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2338273..2339061) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2338273..2339061) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2339051..2339995) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2339051..2339995) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2340028..2340858) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2340028..2340858) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2340866..2342233) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2340866..2342233) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2342297..2342316) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2342303) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2342305..2342394) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2342354..2342373 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2342362 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2342391..2342410) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2342394) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2342396..2342812) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2342421..2342429) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2342463..2342960 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2342463..2342960 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2342796..2342814) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2342812) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2342814..2342944) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2342830..2342836) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2342924..2342935) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2342944) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2342950..2342956) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2342982..2343569) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2342982..2343569) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2343010) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2343566..2345890) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2343566..2345890) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2345891..2346002) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2345987..2346006) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2346002) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2346020..2346027) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2346071..2347729) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2346071..2347729) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2346090) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2347773..2347791) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2347784) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2347807..2347812) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2347881..2349143) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2347881..2349143) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2347891) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2349144..2349233) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2349221..2349240) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2349233) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2349235..2349366) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2349252..2349259) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2349411) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2349415..2350689) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2349415..2350689) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2350690..2350879) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2350866..2350885) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2350879) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2350900..2350904) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2350917..2351921) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2350917..2351921) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2351946..2351965) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2351964) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2351977..2351984) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2352040..2352639) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2352040..2352639) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2352061) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2352652..2354070) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2352652..2354070) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2353959..2353963 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2353978..2353982 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2353978 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2354120..2355217) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2354120..2355217) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2355238..2356794) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2355238..2356794) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2355634..2355637 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2355650..2358091 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2355650 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2355652..2355671 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2356781..2357809) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2356781..2357809) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2357833..2358351) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2357833..2358351) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2358072..2358075 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2358091..2358095 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2358093 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2358348..2360072) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2358348..2360072) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2360073..2360193) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2360194..2360440) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2360194..2360440) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2360237) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2360441..2360567) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2360549..2360568) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2360567) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2360569..2360699) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2360583..2360590) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2360694..2360713) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2360703) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2360727..2360730) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2360825..2360834 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2360848..2360867 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2360850 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2360888..2361223 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2360888..2361223 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2361217 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2361304..2361311 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2361325..2361344 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2361327..2361391 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2361327 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2361392..2361847 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2361392..2361847 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2361955..2361961 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2361975..2361993 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2361982 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2362031..2362852 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2362031..2362852 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2362845 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2362909 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2362916..2362989) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2362916..2362989) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2362950) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2363026..2363045) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2363029) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2363059..2363066) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2363120..2363629) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2363120..2363629) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2363137) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2363645..2364241) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2363645..2364241) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2364254..2364991) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2364254..2364991) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2365073..2365092) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2365089) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2365102..2366202) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2365102..2366202) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2365107..2365112) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2365119) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2366225..2366243) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2366241) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2366258..2366263) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2366317..2367135) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2366317..2367135) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2366329) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2367143..2367583) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2367143..2367583) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2367626..2367645) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2367635) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2367637..2367779) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2367661..2367665) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2367824) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2367827..2368051) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2367827..2368051) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2368100 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2368102..2368120 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2368109..2368128) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2368129) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2368142..2368151) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2368167..2368610) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2368167..2368610) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2368671..2369432) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2368671..2369432) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2368679) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2369435..2371195) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2369435..2371195) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2371229..2371837) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2371229..2371837) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2371607..2371614 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2371627..2371646 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2371629 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2371838..2371933) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2371923..2371942) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2371933) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2371935..2372556) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2371957..2371964) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2372072..2372076 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2372086..2372186 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2372093..2372112 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2372102 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2372130..2372576 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2372130..2372576 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2372146 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2372564 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2372602) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2372620..2373846) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2372620..2373111) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2372620..2373846) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2372620..2373111) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2373960) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2373972..2374151) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2373972..2374151) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2374004) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2374176..2374195) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2374183) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2374208..2374215) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2374216..2375988) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2374216..2375988) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2376015..2376034) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2376029) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2376048..2376055) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2376118) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2376124..2376438) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2376124..2376438) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2376464..2376483) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376478) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2376480..2376689) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2376499..2376501) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2376583..2376693) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2376583..2376693) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2376679..2376697) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2376689) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2376712..2376718) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2376761..2378248) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2376761..2378248) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2378249..2378361) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2378342..2378361) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2378361) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2378376..2378383) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2378465..2379442) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2378465..2379442) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2378473) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2379478..2380251) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2379478..2380251) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2380266..2381042) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2380266..2381042) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2380331 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2381057..2381641) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2381057..2381641) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2381683..2381702) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2381683) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2381715..2381722) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2381746..2383428) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2381746..2383428) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2383457..2383476) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2383465) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2383553) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2383617..2384021) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2383617..2384021) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2383619) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2384036..2386393) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2384036..2386393) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2386414..2388126) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2386414..2388126) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2388127..2388199) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2388200..2388733) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2388200..2388733) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2388740..2388997) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2388740..2388997) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2389024..2389043) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2389040) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2389055..2389062) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2389080..2389099 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2389087 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2389131..2390072 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2389131..2390072 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2389804..2389823) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2389819) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2389837..2389844) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2390055 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2390087) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2390108..2392522) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2390108..2392522) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2390131) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2392538..2393572) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2392538..2393572) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2393573..2393893) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2393654..2393860 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2393654..2393860 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2393883..2394147 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2393883 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2393888..2393907) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2393890..2393904 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2393893) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2393922..2393925) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2393927..2394673) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2393927..2394673) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2394700..2394719) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2394706..2394712 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2394713) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2394726..2394737 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2394733..2394739) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2394740 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2394792..2395007 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2394792..2395007 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2394989..2396401) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2395018..2395025 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2395041..2395060 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2395049 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2395076..2396182 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2395076..2396182 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2396218..2396221 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2396237..2396256 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2396241 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2396285..2397697 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2396285..2397697 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2396387..2396406) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2396401) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2396419..2396428) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2397694..2399028 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2397694..2399028 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2398727,2398729) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2399026 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2399065) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2399067..2399309) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2399067..2399309) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2399310..2399481) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2399369..2399539) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2399369..2399539) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2399482..2401278) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2399482..2401278) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2399584..2399602) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2399602) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2399614..2399622) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2401275 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2401303..2401322) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2401313) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2401337..2401343) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2401373..2401429) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2401397) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2401430..2402932) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2401430..2402932) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2402803) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2402907..2403007) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2402947) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2402951..2403796) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2402951..2403796) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2403797..2404738) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2403797..2404738) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2404774..2406075) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2404774..2406075) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2406106..2407290) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2406106..2407290) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2407287..2408105) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2407287..2408105) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2408083..2408772) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2408083..2408772) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2408789..2410471) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2408789..2410471) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2410485..2411975) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2410485..2411975) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2412068..2412087) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2412075) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2412077..2412152) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2412102..2412109) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2412153..2413124) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2412153..2413124) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2413125..2413253) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2413238..2413257) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2413253) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2413272..2413275) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2413321..2414406) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2413321..2414406) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2413335) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2414432..2414451) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2414455) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2414466..2414473) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2414524..2414533 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2414539 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2414545..2414560 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2414590..2414982 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2414590..2414982 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2414953 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2414998..2415304 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2414998..2415267) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2414998..2415267) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2415014) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2415183) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2415261 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2415324..2415683) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2415324..2415683) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2415337) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2415715..2415915) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2415715..2415915) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2415928..2416449) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2415928..2416449) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2416511..2416650) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2416511..2416650) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2416647..2416666) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2416657) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2416659..2416723) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2416680..2416687) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2416705..2416724) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2416723) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2416740..2416744) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2416842..2416849 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2416863..2416881 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2416863 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2416895..2417560 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2416895..2417560 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2417538 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2417592..2418287) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2417592..2418287) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2417614) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2417658) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2418309..2418749) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2418309..2418749) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2418771..2418790) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2418790) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2418806..2418809) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2418883..2419608) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2418883..2419608) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2418912) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2419586..2421367) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2419586..2421367) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2421451..2421454 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2421463..2421482) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2421468) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2421469..2421488 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2421476 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2421534..2422316 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2421534..2422316 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2422300 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2422350) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2422357..2424288) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2422357..2424288) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2424332..2424579) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2424332..2424579) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2424335..2424344) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2424335) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2424390) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2424590..2424609) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2424603) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2424605..2424685) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2424625..2424629) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2424686..2425531) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2424686..2425531) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2425551..2425569) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2425557) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2425585..2425590) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2425610..2426251) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2425610..2426251) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2426285..2427220) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2426285..2427220) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2427248..2428666) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2427248..2428666) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2428695..2428714) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2428703) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2428729..2428732) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2428781..2429239) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2428781..2429239) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2428800) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2429240..2429387) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2429378..2429397) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2429387) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2429389..2429467) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2429412..2429415) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2429512) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2429513..2429893) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2429513..2429893) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2429894..2430048) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2430028..2430047) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2430035 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2430036..2430055 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2430048) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2430062..2430068) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2430126..2430137) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2430132..2431154) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2430132..2431154) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2430133) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2430152..2430158) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2431198..2431217) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2431229) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2431230..2431237) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2431360..2431740) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2431360..2431740) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2431384) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2431741..2431871) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2431796..2431800 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2431816..2431835 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2431817..2431923 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2431817 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2431861..2431880) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2431871) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2431895..2431902) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2431924..2433114 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2431924..2433114 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2432746..2432764) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2432762) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2432780..2432785) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2433138..2433980 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2433138..2433980 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2433753..2433758 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2433774..2433792 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2433775 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2433973 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2434013) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2434022..2434615) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2434022..2434615) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2434631..2435263) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2434631..2435263) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2435264..2435428) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2435429..2436259) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2435429..2436259) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2436282..2438924) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2436282..2438924) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2438979..2438998) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2438988) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2439012..2439019) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2439048..2439167) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2439091) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2439168..2440907) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2439168..2440907) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2440900..2441622) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2440900..2441622) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2441690..2441709) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2441700) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2441702..2441802) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2441723..2441729) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2441834..2442772) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2441834..2442772) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2441847) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2442816..2444087) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2442816..2444087) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2443872..2443891) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2443884) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2444088..2444170) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2444170) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2444172..2444250) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2444172..2444191) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2444207..2444211) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2444251..2445369) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2444251..2445369) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2444864 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2445211..2445214 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2445219 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2445348 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2445370..2445576) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2445544..2445556 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2445555 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2445562..2445581) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2445576) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2445596..2445600) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2445696) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2445703..2446167) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2445703..2446167) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2446180..2446199) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2446194) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2446196..2447381) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2446196..2446201 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2446212..2446220) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2446216..2446234 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2446222 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2446264..2447379 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2446264..2447379 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2447350 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2447412..2447795) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2447412..2447795) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2447426) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2447796..2447887) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2447888..2449645) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2447888..2449645) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2449688..2450647) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2449688..2450647) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2450648..2450749) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2450738..2450757) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450749) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2450773..2450777) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2450831..2451808) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2450831..2451808) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2450858) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2451793..2452665) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2451793..2452665) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2452627..2452632 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2452648..2452666 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2452652..2453826 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2452652 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2452666..2452749) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2452738..2452757) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2452749) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2452751..2452903) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2452773..2452777) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2452905..2452999) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2452948) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2453000..2454232) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2453000..2454232) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2454233..2454349) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2454337..2454356) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2454349) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2454369..2457716) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2454369..2457716) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2454370..2454377) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2455381..2455390 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2455402..2455417 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2455402 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2455590..2455609) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2455609) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2455623..2455630) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2457747..2457766) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2457765) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2457780..2457787) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2457805..2457810 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2457822 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2457826..2457844 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2457856..2458197 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2457856..2458197 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2458194..2458697 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2458194..2458697 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2458730..2458733 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2458748..2458767 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2458748 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2458799..2458990 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2458799..2458990 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2458800) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2458966 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2459008..2459949) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2459008..2459949) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2459011..2459382 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2459043) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2459351..2459360 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2459374..2459393 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2459384..2459778 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2459384 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2459740..2459746 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2459762..2459781 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2459780..2460079 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2459780 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2459968..2459987) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2459984) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2459986..2460400) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2460002..2460005) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2460080..2460382 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2460080..2460382 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2460383..2462178 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2460401..2461720) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2460401..2461720) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2461746..2461765) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461767) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2461780..2461785) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2461896..2462798) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2461896..2462798) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2462817..2464067) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2462817..2464067) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2464085..2464777) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2464085..2464777) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2464824..2466152) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2464824..2466152) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2466149..2466430) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2466149..2466430) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2466445..2467449) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2466445..2467449) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2467446..2468225) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2467446..2468225) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2468222..2468929) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2468222..2468929) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2468959..2469678) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2468959..2469678) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2469504..2469511 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2469526..2469545 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2469526 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2469700..2470512) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2469700..2470512) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2470526..2471335) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2470526..2471335) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2471349..2471885) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2471349..2471885) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2471922..2471929 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2471940..2471959) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2471943..2471962 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2471946..2472037 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2471946 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2471956) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2471973..2471980) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2472038..2472964 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2472038..2472964 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2472440..2472969) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2473014) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2473015..2473698) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2473015..2473698) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2473699..2473760) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2473761..2474528) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2473761..2474528) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2474573..2474592) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2474595) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2474608..2474610) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2474655..2474891) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2474655..2474891) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2474740 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2474760) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2474851..2476236) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2474851..2476236) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2476233..2477444) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2476233..2477444) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2477445..2477522) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2477515..2477534) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2477521) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2477549..2477556) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2477614..2478126) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2477614..2478126) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2477632) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2478152..2478171) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2478160) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2478185..2478192) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2478211..2479398) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2478211..2479398) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2478226) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2479399..2479503) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2479488..2479507) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2479503) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2479505..2479634) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2479523..2479527) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2479571..2479774) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2479571..2479774) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2479632..2479643) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2479634) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2479658..2479664) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2479746..2480735) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2479746..2480735) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2479764) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2480796..2481299) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2480796..2481299) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2480802) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2481016..2481116 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2481076 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2481295 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2481322..2481341) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2481338) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2481355..2481362) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2481409..2481864) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2481409..2481864) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2481437) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2481878..2482558) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2481878..2482558) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2481970) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2481977..2481988) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2482003..2482009) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2482296) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2482571..2482589) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2482585) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2482604..2482609) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2482633..2483127) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2482633..2483127) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2482648) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2483140..2484147) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2483140..2484147) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2484171..2484186) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2484188) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2484190..2484269) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2484198..2484207) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2484247..2484266 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2484257 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2484262..2484281) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2484266..2484332 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2484269) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2484297..2484301) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2484333..2485136 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2484333..2485136 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2485066 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2485124 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2485168..2486757) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2485168..2486757) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2485177) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2486777..2488366) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2486777..2488366) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2488412..2488429) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2488417) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2488445..2488451) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2488544) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2488545..2488754) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2488545..2488754) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2488750..2488754 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2488754 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2488763..2488777 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2488775..2488786) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2488786) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2488801..2488807) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2488848..2490053) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2488848..2490053) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2490057..2491202) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2490057..2491202) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2491203..2492346) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2491289..2491296 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2491307..2491396 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2491307 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2491309..2491328 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2491397..2492734 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2491397..2492734 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2492332..2492351) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2492346) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2492366..2492373) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2492710 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2492829..2494517) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2492829..2494517) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2492830) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2494518..2494623) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2494600..2494608 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2494611..2494630) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2494619..2494638 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2494623) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2494623 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2494624..2494713 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2494625..2495184) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2494646..2494648) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2494714..2495520 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2494714..2495520 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2495188..2495207) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2495201) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2495219..2495226) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2495470..2495516) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2495492) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2495517..2496140) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2495517..2496140) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2495521..2495863 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2495841..2495848 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2495863..2495882 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2495865..2496008 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2495865 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2495980..2495984 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2496000..2496019 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2496010..2496140 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2496010 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2496142..2496266 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2496142 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2496156..2496174) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2496158..2496177 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2496174) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2496185..2496193) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2496267..2496758 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2496267..2496758 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2496737 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2496796..2498535) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2496796..2498535) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2496814) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2498009..2498016 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2498030..2498048 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2498033 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2498035..2498630 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2498565..2498584) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2498573) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2498575..2499408) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2498611..2498618 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2498632..2498829 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2498632..2498651 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2498632 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2498689..2498821 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2498689..2498821 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2498830..2499432 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2498830..2499432 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2499355 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2499410..2499629) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2499418 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2499453) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2499465 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2499510..2499683 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2499625..2499643) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2499637) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2499641 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2499658..2499664) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2499703..2500971) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2499703..2500971) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2499729) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2500995..2501268) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2500995..2501268) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2501016..2501159) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2501059) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2501266..2501285) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2501278) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2501298..2501305) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2501313..2503031) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2501313..2503031) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2503045..2503052 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2503059..2503078) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2503067..2503086 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2503073 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2503082) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2503092..2503098) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2503115..2503122 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2503136..2503155 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2503139 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2503192..2503824 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2503192..2503824 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2503397..2503405 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2503419..2503438 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2503425 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2503851..2504495 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2503851..2504495 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2504492..2505655 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2504492..2505655 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2505646 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2505666..2506394) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2505666..2506394) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2505702) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2506384..2507202) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2506384..2507202) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2507265..2508269) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2507265..2508269) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2507282) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2508304..2508323) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2508319) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2508321..2508429) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2508429..2508448) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2508429) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2508431..2508496) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2508462..2508468) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2508542) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2508545..2509621) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2508545..2509621) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2509662..2509681) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2509682) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2509684..2509784) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2509696..2509703) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2509718 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2509772..2509791) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2509784) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2509805..2509811) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2509857..2510183) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2509857..2510183) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2509866) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2510207..2510662) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2510207..2510662) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2510693..2511115) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2510693..2511115) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2511136..2511154) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2511149) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2511168..2511174) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2511188..2511206) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2511197) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2511217..2511225) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2511277..2512575) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2511277..2512575) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2511286) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2512600..2512619) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2512601) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2512603..2512799) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2512632..2512641) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2512782..2512801) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2512799) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2512813..2512819) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2512825..2515683) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2512825..2515683) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2515717..2515736) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2515727) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2515752..2515756) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2515826) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2515843..2516448) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2515843..2516448) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2516464..2517273) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2516464..2517273) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2517288..2517611) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2517288..2517611) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2517612..2517750) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2517650..2517766) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2517650..2517766) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2517737..2517756) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2517750) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2517758..2517765 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2517780..2517799 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2517785 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2517846..2518292 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2517846..2518292 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2518293..2519021 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2518347..2519420) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2518347..2519420) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2518366) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2519442..2519461) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2519446) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2519475..2519482) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2519517..2519520 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2519535..2519554 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2519540 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2519579..2519896 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2519579..2519896 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2519896 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2519949..2521649) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2519949..2521649) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2519968) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2521681..2521699) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2521688) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2521714..2521720) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2521731..2522501) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2521731..2522501) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2522502..2522590) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2522588..2522607) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2522590) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2522623..2522627) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2522647..2523288) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2522647..2523288) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2522657) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2522722) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2523314..2523333) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2523323) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2523325..2523773) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2523349..2523353) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2523432..2523438 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2523453..2523464 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2523460 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2523495..2523773 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2523495..2523773 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2523774..2523944 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2523774..2524388) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2523774..2524388) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2523922 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2524389..2524724) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2524716..2524735) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2524724) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2524750..2524757) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2524751..2526907) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2524751..2526907) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2526448,2526450) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2526933..2527862) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2526933..2527862) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2527911..2528825) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2527911..2528825) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2528588..2528606) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2528596) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2528620..2528626) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2528851..2529402) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2528851..2529402) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2529265..2529284 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2529268 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2529425..2529444) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2529437) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2529460..2529463) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2529485..2529492 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2529503..2529522 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2529506..2529517) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2529510 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2529520) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2529531..2529537) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2529551..2530486 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2529551..2530486 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2530462 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2530520..2531911) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2530520..2531911) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2530532) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2531912..2532352) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2531938..2531943 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2531957..2531976 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2531970 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2532008..2533306 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2532008..2533306 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2532329..2532348) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2532352) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2532363..2532369) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2533293 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2533346..2534503) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2533346..2534503) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2533371) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2533619..2533624 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2533639..2533657 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2533647 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2534500..2535210) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2534500..2535210) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2535224..2535239) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2535241) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2535251..2535260) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2535267..2535268 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2535280..2535385 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2535280 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2535288..2535298 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2535351..2535357 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2535372..2535391 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2535387..2535500 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2535387 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2535501..2535722 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2535501..2535722 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2535705 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2535774 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2535843..2536562) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2535843..2536562) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2535857) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2536628) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2536631..2538265) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2536631..2538265) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2538297..2538316) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2538313) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2538383..2538387 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2538403..2538422 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2538421 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2538467..2539729 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2538467..2539729 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2539730..2539828 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2539802..2539808 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2539824..2539842 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2539830..2539917 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2539830 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2539918..2541456 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2539918..2541456 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2541436 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2541493..2541675) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2541493..2541675) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2541512) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2541690..2541708) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2541710) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2541724..2541729) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2541743..2542411) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2541743..2542411) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2542433..2543719) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2542433..2543719) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2543731..2544234) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2543731..2544234) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2544231..2545352) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2544231..2545352) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2545360..2546325) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2545360..2546325) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2546351) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2546352..2546371) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2546386..2546393) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2546481..2546488 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2546501 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2546504..2546523 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2546541..2548859 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2546541..2548859 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2548849 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2548900..2550396) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2548900..2550396) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2548902) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2550421..2551281) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2550421..2551281) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2551357..2551376) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2551366) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2551392..2551399) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2551488..2552249) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2551488..2552249) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2551517) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2552250..2552325) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2552326..2553513) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2552326..2553513) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2553582..2554589) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2553582..2554589) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2554592..2555287) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2554592..2555287) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2555284..2556453) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2555284..2556453) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2555320..2555327 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2555342..2555361 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2555360 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2556443..2557789) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2556443..2557789) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2556859..2556863 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2556878 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2556879..2556897 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2557779..2558555) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2557779..2558555) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2558556..2558648) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2558634..2558653) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2558648) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2558668..2558675) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2558765..2559664) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2558765..2559664) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2559687..2559705) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2559704) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2559716..2559724) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2559794..2559801 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2559817..2559836 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2559823 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2559882..2560916 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2559882..2560916 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2560865..2560872 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2560887..2560895 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2560904 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2560950..2562230 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2560950..2562230 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2562223..2563134 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2562223..2563134 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2563131..2563961 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2563131..2563961 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2563934..2563938 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2563954..2563973 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2563962 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2563981..2565279 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2563981..2565279 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2565260 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2565301..2565612) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2565301..2565612) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2565312) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2565636..2565655) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565644) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2565670..2565677) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2565678 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2565729..2568143) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2565729..2568143) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2565733) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2568144..2568239) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2568253..2568467) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2568253..2568467) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2568284) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2568479..2568498) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2568500) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2568504..2568509 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2568513..2568518) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2568525..2568543 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2568538..2568978 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2568538 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2568570..2568905) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2568570..2568905) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2568900..2569164) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2569149..2569168) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2569164) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2569183..2569190) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2569203..2569210 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2569224..2569243 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2569240 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2569242..2569309 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2569310..2570095 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2569310..2570095 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2570096..2570152 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2570332..2571525) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2570332..2571525) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2570352) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2571526..2571624) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2571605..2571624) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2571624) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2571638..2571645) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2571662..2571665 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2571680..2571699 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2571684 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2571714..2572460 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2571714..2572460 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2572355 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2572454 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2572497..2574437) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2572497..2574437) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2572508) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2574427..2575188) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2574427..2575188) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2575212..2575230) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2575231) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2575290..2576294) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2575290..2576294) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2575329) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2576287..2576982) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2576287..2576982) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2577006..2577024) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577018) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2577040..2577043) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2577079..2578389) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2577079..2578389) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2577101) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2578379..2579074) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2578379..2579074) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2579089..2580066) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2579089..2580066) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2580096..2581082) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2580096..2581082) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2580952..2580961 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2580968 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2580974..2580989 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2581076..2581954) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2581076..2581954) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2581947..2582339) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2581947..2582339) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2582340..2582584) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2582373..2582510) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2582373..2582510) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2582508 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2582579..2582598) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2582584) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2582612..2582619) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2582665..2582937) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2582665..2582937) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2582672) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2582977..2582988) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2582981..2582989 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2582981) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2582992 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2583003..2583009) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2583003..2583021 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2583032..2583037 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2583051..2583070 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2583058 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2583099..2584067 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2583099..2584067 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2584064..2584648 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2584064..2584648 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2584612 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2584638..>2584769) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2584638..>2584769) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2584679) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2584772..2584773 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2584773..2584788) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2584779..2584798) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2584788) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2584790..2584924) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2584810..2584817) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2584899..2584918) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2584924) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2585017..2586408) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2585017..2586408) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2585025) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2586409..2586543) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2586544..2588442) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2586544..2588442) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2587600..2587606 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2587621..2587632 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2587633 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2588443..2588566) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2588592..2589794) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2588592..2589794) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2588611) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2589837..2589848) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2589843) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2589845..2589961) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2589862..2589868) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2589962..2590100) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2589962..2590100) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2590060 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2590109..2590128) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2590124) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2590145..2590149) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2590221..2590228 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2590240 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2590242..2590261 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2590297..2591880 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2590297..2591880 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2591869 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2591919..2592161) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2591919..2592161) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2591933) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2592213..2592986) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2592213..2592986) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2592987..2593077) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2593053..2593062 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2593066..2593085) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2593074 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2593075..2593094 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2593079) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2593100..2593107) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2593137..2594141 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2593137..2594141 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2594154..2594936 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2594154..2594936 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2594158..2595706) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2594911..2595723 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2594911..2595723 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2595708 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2595750..2596226) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2595750..2596226) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2595751) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2596256..2596275) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2596269) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2596271..2596405) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2596405) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2596407..2596418) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2596433..2596439) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2596435..2596839) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2596435..2596839) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2596867..2596886) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2596884) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2596886..2596972) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2596899..2596908) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2597005..2597442) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2597005..2597442) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2597017) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2597459..2597477) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2597477) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2597479..2597704) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2597492..2597498) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2597534..2597553 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2597535..2597711 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2597535..2597711 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2597536 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2597705..2598142) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2597705..2598142) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2597731 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2598161..2598180) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2598182) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2598191..2598199) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2598262..2598735) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2598262..2598735) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2598271) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2598358) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2598736..2599087) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2598807..2598814 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2598827..2598846 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2598832 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2598864..2599091 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2598864..2599091 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2599088..2599651) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2599088..2599651) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2599676..2599695) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2599691) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2599745..2599993) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2599745..2599993) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2599766) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2600021..2600040) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2600054..2600061) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2600058) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2600120..2600126 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2600140..2600151 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2600152 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2600198..2601529 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2600198..2601529 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2601573..2602613 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2601573..2602613 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2602607..2602613 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2602628..2602639 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2602638 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2602667..2602825 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2602667..2602825 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2602814 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2602844..2603731) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2602844..2603731) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2602867) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2603721..2605028) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2603721..2605028) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2605034..2605786) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2605034..2605786) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2605805..2606725) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2605805..2606725) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2606761..2606772) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606762) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2606764..2606855) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2606786..2606792) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2606840 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2606841..2606860) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2606843..2606855 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2606855) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2606857..2606938) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2606875..2606882) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2606938) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2606947..2606966) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2606980..2606987) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2607005..2608120) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2607005..2608120) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2607048) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2608117..2609577) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2608117..2609577) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2609020..2609038) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2609024) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2609053..2609059) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2609666) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2609668..2610483) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2609668..2610483) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2610518..2611342) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2610518..2611342) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2610600..2610619) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2610600) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2610635..2610638) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2610766) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2610776..2610787) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2610802..2610808) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2611330..2613072) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2611330..2613072) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2613069..2614484) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2613069..2614484) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2614485..2614597) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2614577..2614596) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2614597) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2614599..2614749) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2614612..2614615) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2614710..2614716 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2614730..2614749) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2614730..2614741 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2614738 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2614749) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2614763..2614772) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2614774..2615493 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2614774..2615493 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2614844..2615501) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2615482 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2615502..2616320) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2615502..2616320) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2616341..2616360) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2616355) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2616375..2616383) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2616421..2616429 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2616442..2616461 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2616443 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2616492..2617778 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2616492..2617778 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2617775..2618725 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2617775..2618725 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2618728..2619951 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2618728..2619951 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2619875) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2619952..2620519 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2620025..2620456) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2620025..2620456) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2620051) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2620458..2621513) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2620458..2621513) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2621528..2622661) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2621528..2622661) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2622694..2622713) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2622713) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2622726..2622735) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2622799..2622808 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2622822..2622841 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2622824 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2622851..2623924 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2622851..2623924 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2623148..2623154 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2623165 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2623168..2623179 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2623913 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2623951..2623957 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2623972 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2623973..2623991 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2624004..2624471 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2624004..2624471 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2624443 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2624502..2626898) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2624502..2626898) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2624517) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2626885..2628339) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2626885..2628339) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2628336..2629367) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2628336..2629367) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2629391..2630533) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2629391..2630533) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2630530..2632413) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2630530..2632413) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2631239..2632658 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2632445..2632460) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2632458) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2632475..2632480) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2632525) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2632646..2632717) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2632646..2632717) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2632743..2632833) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2632743..2632833) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2632837..2632911) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2632837..2632911) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2632922..2632998) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2632922..2632998) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2633014..2633087) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2633014..2633087) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2633098..2633173) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2633098..2633173) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2633191..2633266) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2633191..2633266) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2633279..2633355) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2633279..2633355) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2633367..2633443) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2633367..2633443) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2633461..2633553) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2633461..2633553) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2633560..2633636) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2633560..2633636) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2633639..2633715) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2633639..2633715) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2633735..2633807) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2633735..2633807) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2633813..2633889) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2633813..2633889) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2633905..2633981) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2633905..2633981) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2633991..2634076) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2633991..2634076) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2634091..2634165) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2634091..2634165) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2634171..2634257) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2634171..2634257) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2634268..2634343) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2634268..2634343) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2634381..2634456) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2634381..2634456) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2634489..2634564) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2634489..2634564) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2634585..2634702) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2634585..2634702) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2634758..2637685) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2634758..2637685) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2637853..2639407) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2637853..2639407) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2639209,2639211) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2639408..2639699) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2639535..2639543 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2639541 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2639651 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2639672..2639691) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2639699) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2639701..2640667) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2639705..2639712) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2639824..2639827 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2639839 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2639842..2639861 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2639872..2639973 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2639872..2639973 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2639972 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2640073..2640651 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2640073..2640651 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2640641 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2640693..2641214) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2640693..2641214) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2640711) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2640783) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2641232..2642761) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2641232..2642761) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2642782..2643306) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2642782..2643306) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2643350..2643365) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2643356) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2643358..2643445) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2643377..2643386) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2643430..2643448) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2643440 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2643444..2643463 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2643445) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2643463..2643468) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2643474..2643962 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2643474..2643962 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2643939 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2643968..2644546) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2643968..2644546) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2643984..2644375 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2643995) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2644580..2644599) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2644589) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2644613..2644620) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2644634..2645842) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2644634..2645842) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2644655) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2645611..2645630) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2645623) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2645645..2645652) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2645859..2647331) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2645859..2647331) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2647382..2647401) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2647383) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2647416..2647423) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2647443..2647449 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2647463..2647482 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2647478 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2647530..2648072 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2647530..2648072 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2648055 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2648149..2648156 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2648169..2648269 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2648169 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2648171..2648190 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2648270..2648815 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2648270..2648815 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2648802 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2648907..2648914 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2648928..2648947 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2648935 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2648940..2649108 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2648940..2649108 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2649089 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2649181..2649849 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2649181..2649849 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2649856..2651193 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2649856..2651193 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2651179 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2651229..2651492) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2651229..2651492) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2651247) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2651532..2651551) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2651534) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2651564..2651571) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2651601..2652449) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2651601..2652449) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2652494..2652513) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2652504) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2652528..2652535) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2652610..2654145) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2652610..2654145) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2652619) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2653803..2653903 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2653863 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2653929 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2654146..2654313) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2654302..2654321) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2654313) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2654315..2655192) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2654336..2654343) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2654555..2654564 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2654578..2654597 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2654578 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2654630..2655115 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2654630..2655115 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2655116..2655402 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2655222..2655294) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2655222..2655294) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2655237) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2655281) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2655305..2655324) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2655325) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2655339..2655342) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2655359 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2655402..2656232) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2655402..2656232) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2655413) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2656233..2656324) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2656325..2657491) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2656325..2657491) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2657487..2657491 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2657499..2657513 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2657515..2657534) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2657515 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2657534) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2657548..2657555) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2657613..2657620 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2657626 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2657631..2657650 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2657673..2658659 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2657673..2658659 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2658630 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2658700..2659974) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2658700..2659974) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2658713) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2660000..2660314) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2660000..2660314) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2660332..2661789) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2660332..2661789) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2661794..2662570) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2661794..2662570) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2662604..2662623) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2662620) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2662627..2664696) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2662627..2664696) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2664729..2664748) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2664741) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2664762..2664768) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2664834..2666822) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2664834..2666822) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2664853) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2666826..2666833 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2666843..2666861) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2666849..2666868 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2666856) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2666865 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2666875..2666882) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2666931 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2666936..2668921) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2666936..2668921) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2666941) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2668942..2668960) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2668957) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2668959..2669046) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2668974..2668981) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2669047..2671035) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2669047..2671035) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2671060..2671078) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2671075) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2671092..2671099) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2671212..2673200) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2671212..2673200) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2671231) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2673221..2673239) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2673242) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2673252..2673259) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2673302..2673311 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2673325..2673344 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2673328 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2673358..2674095 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2673358..2674095 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2673383..2673402) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2673391) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2673418..2673422) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2674096..2676916 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2674109..2674363) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2674109..2674363) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2674135) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2674364..2674620) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2674621..2675019) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2674621..2675019) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2674979..2675113) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2674979..2675113) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2675062..2675081) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2675069) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2675096..2675102) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2675139..2676803) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2675139..2676803) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2675155) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2676111..2676130) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2676116) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2676144..2676151) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2676828..2676846) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2676845) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2676862..2676867) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2676930..2678219) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2676930..2678219) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2676939) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2677748..2677754 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2677768..2677786 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2677774 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2677778..2678430 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2678263..2678940) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2678263..2678940) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2678273) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2678615..2679291 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2678975..2678994) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2678982..2679245) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2678982..2679245) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2678996) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2679008..2679015) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2679257..2679275) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2679271) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2679291..2679296) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2679292..2679624 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2679292..2679624 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2679309..2679315 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2679330..2679347 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2679341 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2679621..2680607 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2679621..2680607 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2680582) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2680604..2681008) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2680604..2681008) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2681009..2681067) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2681068..2681439) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2681068..2681439) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2681498..2682850) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2681498..2682850) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2681509) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2681665..2681683) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2681682) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2681699..2681704) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2682823) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2682826..2682837) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2682882..2682901) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2682888) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2682890..2682961) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2682916..2682919) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2682962..2684134) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2682962..2684134) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2683297..2684218 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2684167..2684186) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2684180) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2684203..2684206) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2684238..2685401) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2684238..2685401) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2684253) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2685416..2685435) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2685434) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2685436..2685591) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2685450..2685457) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2685487..2685493 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2685508..2685526 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2685518 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2685519..2685577 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2685564..2685570 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2685566..2685577) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2685579 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2685584..2685595 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2685591..2685597) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2685591) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2685593..2685904) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2685631..2685867 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2685631..2685867 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2685827 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2685893 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2685945..2686337) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2685945..2686337) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2685949) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2686379..2686398) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2686386) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2686388..2686538) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2686414..2686418) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2686441..2686447 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2686454..2687438 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2686454 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2686462..2686480 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2686539..2687699) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2686539..2687699) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2687591..2687597 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2687609 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2687611..2687615 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2687700..2688200) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2687700..2688200) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2688230..2688249) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2688236..2688242 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2688251) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2688257..2688268 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2688257 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2688260..2688267) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2688269..2688347 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2688348..2689169 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2688348..2689169 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2689149 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2689196) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2689198..2689458) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2689198..2689458) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2689448..2689451 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2689466..2689485 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2689478 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2689479..2689544 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2689484..2689503) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2689489) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2689515..2689521) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2689545..2690708 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2689545..2690708 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2690771..2690777 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2690789..2690808 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2690799 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2690834..2692120 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2690834..2692120 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2691836..2692578) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2692115..2692122 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2692136..2692155 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2692137 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2692166..2692552 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2692166..2692552 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2692534 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2692579..2693196) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2692579..2693196) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2693231..2693249) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2693248) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2693250..2695338) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2693264..2693269) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2693312..2693315 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2693330..2693349 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2693341 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2693407..2694585 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2693407..2694585 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2694623..2694629 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2694641..2694660 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2694646 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2694678..2696552 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2694678..2696552 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2695318..2695337) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2695338) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2695351..2695360) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2696573..2696986 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2696573..2696986 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2696978 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2697189..2697746) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2697189..2697746) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2697210..2697229 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2697220 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2697230) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2697242..2697923 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2697772..2697791) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2697780) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2697807..2697811) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2697924..2699525 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2697924..2699525 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2699518..2700225 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2699518..2700225 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2700210 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2700389..2700396 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2700407..2700696 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2700407 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2700411..2700430 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2700697..2701776 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2700697..2701776 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2701852..2703384 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2701852..2703384 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2703377..2704423 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2703377..2704423 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2704424..2705383 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2704424..2705383 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2705384..2705505 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2705478..2705481 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2705496..2705515 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2705507 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2705537..2706883 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2705537..2706883 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2706866 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2706919..2707134) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2706919..2707134) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2707074..2707080 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2707094..2707105 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2707098 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2707145..2707163) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2707152) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2707177..2707184 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2707179..2707184) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2707199..2707294 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2707199..2707218 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2707199 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2707257..2707261 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2707277..2707296 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2707296..2707445 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2707296 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2707365..2709770 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2707365..2709770 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2709763..2710194 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2709763..2710194 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2710194..2710535 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2710194..2710535 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2710426..2710526 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2710486 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2710528..2712009 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2710528..2712009 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2711261..2713129) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2712015..2712491 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2712015..2712491 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2712491..2712775 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2712491..2712775 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2712759..2713133 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2712759..2713133 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2713104 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2713172..2713552) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2713172..2713552) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2713174) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2713571..2714215) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2713571..2714215) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2714216..2714295) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2714296..2716605) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2714296..2716605) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2715290..2715297 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2715311..2715330 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2715326 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2716199..2717170 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2716199 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2716211..2716227 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2716620..2716787) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2716620..2716787) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2716775..2717673) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2716775..2717673) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2717674..2717787) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2717781..2717800) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2717787) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2717814..2717820) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2717858..2717998) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2717858..2717998) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2717887) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2717999..2718085) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2718069..2718088) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718085) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2718102..2718108) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2718185..2718203) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718195) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2718218..2718224) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2718220..2718345 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2718220..2718345 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2718373..2718802) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2718398..2718403 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2718415) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2718418..2718436 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2718420 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2718459..2718827 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2718459..2718827 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2718803..2720032) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2718803..2720032) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2718828..2720141 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2720067..2720086) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2720086) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2720099 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2720101..2720108) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2720169..2721641) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2720169..2721641) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2720179) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2721522..2721526 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2721529 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2721639 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2721657..2722208) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2721657..2722208) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2722230..2722249) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722243) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2722262..2722269) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2722305..2722703) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2722305..2722703) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2722704..2722774) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2722775..2723023) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2722775..2723023) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2723046..2723065) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2723057) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2723081..2723084) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2723096..2723317) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2723096..2723317) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2723123) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2723311 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2723335..2723354) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2723341) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2723367..2723376) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2723377..2724486) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2723377..2724486) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2724138..2724145 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2724160..2724179 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2724169..2724563 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2724169 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2724534..2724553) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2724550) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2724552..2724992) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2724555..2724557 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2724565 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2724567..2724572) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2724573..2724592 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2724601..2724990 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2724601..2724990 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2725031..2725267) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2725031..2725267) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2725037) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2725287..2725306) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2725301) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2725303..2725443) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2725320..2725329) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2725444..2725974) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2725444..2725974) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2725994..2726013) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2726005) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2726007..2726093) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2726025..2726033) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2726088..2726107) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726095) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2726121..2726130) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2726172..2726903) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2726172..2726903) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2726202) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2726918..2726937) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726929) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2726952..2726959) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2726966..2727421) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2726966..2727421) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2727374..2727380 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2727395..2727413 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2727403..2729770 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2727403 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2727453..2730683) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2727453..2730683) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2730680..2735167) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2730680..2735167) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2734442..2734448 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2734463..2734481 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2734469..2735431 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2734469 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2735228..2736583) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2735228..2736583) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2735249) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2736598..2736837) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2736598..2736837) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2736907..2737200) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2736907..2737200) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2736917) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2737194 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2737201..2737279) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2737242..2737249 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2737259..2737278) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2737260 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2737264..2737281 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2737279) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2737293..2737300) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2737338..2737343 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2737358..2737377 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2737370..2737476 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2737370 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2737545..2737551 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2737565..2737584 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2737568 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2737673..2737676 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2737685 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2737688..2737707) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2737692..2737711 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2737710) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2737721..2738989 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2737721..2738989 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2737722..2737729) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2739049..2739068 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2739054 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2739091..2740227 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2739091..2740227 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2740227 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2740276..2740284 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2740294 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2740296..2740314 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2740339..2741016 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2740339..2741016 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2741000 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2741060..2741269) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2741060..2741269) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2741072) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2741285..2748421) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2741285..2748421) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2748441..2749379) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2748441..2749379) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2749407..2751026) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2749407..2751026) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2751055..2752251) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2751055..2752251) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2752099..2752106 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752121..2752140 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2752128 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2752277..2753062) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2752277..2753062) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2753063..2753172) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2753167..2753186) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2753172) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2753174..2753255) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2753200..2753207) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2753256..2754125) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2753256..2754125) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2754126..2754206) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2754190..2754209) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2754206) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2754223..2754230) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2754339..2754935) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2754339..2754935) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2754936..2755020) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2754971..2754978 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2754988 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2754993..2755012 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2755014..2755028) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2755020) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2755036..2755040) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2755036..2755638 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2755036..2755638 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2755624 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2755708..2757036) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2755708..2757036) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2755724) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2757090..2757109) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2757093) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2757124..2757131) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2757183..2758685) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2757183..2758685) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2757198) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2758250..2758264 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2758266 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2758686..2758760) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2758708..2758715 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2758726..2758745 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2758728..2758842 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2758728 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2758755..2758774) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2758765) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2758843..2759319 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2758843..2759319 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2759268 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2759350..2760006) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2759350..2760006) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2759378) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2759654..2759663 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2759677..2759696 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2759694 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2759696..2760142 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2760020) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2760022..2760033) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2760048..2760054) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2760099 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2760110..2760430) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2760110..2760430) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2760124) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2760144..2760354 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2760296..2760396 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2760356..2760465 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2760356 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2760422 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2760449..2760468) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2760454) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2760467..2761018 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2760483..2760490) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2760484..2760627) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2760484..2760627) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2760651..2760670) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2760672) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2760686..2760689) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2760800..2762020) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2760800..2762020) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2760828) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2762021..2762148) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2762148) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2762150..2762214) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2762150..2762168) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2762184..2762189) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2762205..2762224) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2762213) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2762239..2762246) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2762288..2762295 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2762307..2762326 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2762307 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2762352..2763350 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2762352..2763350 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2762375..2762393) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2762390) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2762410..2762415) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2763326 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2763389..2763529) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2763389..2763529) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2763401) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2763530..2763659) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2763640..2763659) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2763659) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2763661..2763908) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2763673..2763679) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2763716..2763723 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2763737..2763756 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2763745 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2763808..2764788 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2763808..2764788 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2763909) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2763913..2763924) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2763938..2763944) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2764756 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2764861) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2764862..2765485) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2764862..2765485) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2765509..2766027) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2765509..2766027) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2766074..2766093) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2766086) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2766088..2766196) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2766183..2766200) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2766194) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2766215..2766222) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2766350) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2766365..2766727) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2766365..2766727) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2766758..2766777) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2766768) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2766791..2766798) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2766806..2767660) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2766806..2767660) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2767376..2767395) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2767384) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2767408..2767417) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2767682..2767701) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2767696) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2767716..2767719) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2767783..2768997) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2767783..2768997) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2768332..2768338 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2768353..2768371 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2768360 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2768364..2769133 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2769034..2769053) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2769039) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2769068..2769075) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2769090 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2769134..2769370) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2769134..2769370) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2769135..2769551 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2769152) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2769335..2769336) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2769340..2769344) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2769342) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2769385..2769404) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2769386) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2769418..2769425) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2769528..2769533 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2769547..2769566 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2769553 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2769633..2770700 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2769633..2770700 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2770684 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2770726..2771052) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2770726..2771052) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2770749) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2771084..2771103) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2771101) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2771116..2771123) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2771136..2771140 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2771152..2771487 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2771152..2771487 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2771153..2771172 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2771158 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2771277) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2771465 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2771529..2773502) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2771529..2773502) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2771541) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2773517..2773535) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2773540) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2773547..2773555) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2773610..2774539) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2773610..2774539) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2773623) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2774536..2775594) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2774536..2775594) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2775594..2776895) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2775594..2776895) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2776780..2776789 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2776804..2776823 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2776811 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2776896..2776977) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2776962..2776981) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2776977) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2776979..2777095) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2776996..2777003) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2777096..2778115) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2777096..2778115) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2777923..2777928 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2777944..2777962 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2777948 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2778138..2778156) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2778145) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2778154..2778159 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2778172..2778177) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2778175..2778239 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2778175..2778193 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2778175 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2778212..2778221 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2778234..2778253 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2778241 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2778268..2778768 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2778268..2778768 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2778795..2779565) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2778795..2779565) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2778823) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2779594..2780028) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2779594..2780028) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2780052..2780327) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2780052..2780327) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2780347..2780366) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2780372) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2780374..2781066) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2780380..2780387) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2780390..2780396 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2780411..2780422 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2780419 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2780442..2781074 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2780442..2781074 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2781035 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2781090..2781986) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2781090..2781986) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2781111) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2781987..2782121) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2782108..2782127) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2782121) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2782143..2782147) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2782161..2782167 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2782181..2782192 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2782193 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2782221..2783201 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2782221..2783201 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2782299) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2782313..2782332) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2782349..2782352) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2783193 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2783229..2783993) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2783229..2783993) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2783245) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2784007..2784025) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2784015) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2784041..2784046) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2784066..2784371) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2784066..2784371) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2784074) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2784385..2784404) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2784408) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2784418..2784426) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2784436..2785824) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2784436..2785824) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2785844..2786665) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2785844..2786665) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2786683..2787531) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2786683..2787531) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2787050..2787055 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2787071..2787089 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2787085 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2787542..2787561) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2787557) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2787569..2787916) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2787569..2787916) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2787929..2787948) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2787948) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2787962..2787968) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2788013..2789353) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2788013..2789353) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2788041) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2789097) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2789410..2789416 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2789430..2789449 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2789432..2789450) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2789438 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2789439..2789527 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2789449) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2789466..2789471) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2789528..2791123 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2789528..2791123 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2791268..2792617 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2791268..2792617 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2792623..2793915 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2792623..2793915 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2793928..2795412 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2793928..2795412 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2795412..2795756 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2795412..2795756 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2795478..2795481 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2795499..2795518 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2795511 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2795731 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2795772..2796159) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2796119..2796128 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2796141..2796160 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2796144 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2796180..2796311) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2796180..2796311 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2796180..2796311 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2796180..2796311) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2796312..2796380 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2796347 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2796517..2797038) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2796517..2797038) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2797029..2799266) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2797029..2799266) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2799267..2800100) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2799267..2800100) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2800097..2800714) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2800097..2800714) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2800206) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2800711..2801703) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2800711..2801703) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2801704..2801790) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2801768..2801787) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2801790) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2801801..2801806) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2801932..2803182) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2801932..2803182) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2803199..2804437) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2803199..2804437) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2804660..2804797 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2804660..2804797 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2804819..2804822 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2804837..2804856 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2804838 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2804879..2805745 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2804879..2805745 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2805748 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2805779..2806882) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2805779..2806882) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2805794) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2806883..2807816) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2806920..2806927 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2806941..2806960 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2806951 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2807002..2807008 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2807019 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2807023..2807042 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2807064..2807792 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2807064..2807792 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2807817..2808671) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2807817..2808671) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2808004..2808023) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2808016) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2808174..2808274) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2808214) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2808685..2809587) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2808685..2809587) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2809591..2810469) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2809591..2810469) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2810527..2811795) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2810527..2811795) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2811686..2811786 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2811746 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2811866) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2811876..2812862) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2811876..2812862) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2812809 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2812812..2812816 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2812905..2812924) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2812918) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2812939..2812946) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2813076) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2813078..2813452) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2813078..2813452) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2813516) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2813523..2813534) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2813548..2813554) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2813555..2814673) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2813555..2814673) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2814698..2814717) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2814704) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2814706..2815316) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2814731..2814737) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2814770..2814779 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2814793..2814812 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2814797 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2814810..2814825) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2814814) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2814832..2814836) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2814832..2814978 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2814832..2814978 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2814978..2815253 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2814978..2815253 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2815122) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2815138..2815152) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2815161..2815165) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2815233 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2815317..2815700) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2815317..2815700) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2815701..2815810) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2815811..2816089) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2815811..2816089) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2816087..2816106) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2816111) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2816121..2816128) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2816252..2816358) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2816295) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2816359..2817756) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2816359..2817756) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2817554 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2817777..2818220) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2817777..2818220) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2818210..2819430) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2818210..2819430) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2819430..2820743) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2819430..2820743) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2820761..2821546) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2820761..2821546) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2821590..2821609) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2821591) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2821623..2821630) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2821647..2821666) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2821656) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2821658..2821739) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2821682..2821686) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2821703..2821950) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2821703..2821950) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2821740..2821877) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2821740..2821877) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2821878..2821962) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2821946..2821965) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2821962) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2821964..2822070) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2821981..2821984) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2822071..2822448) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2822071..2822448) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2822465..2822476) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2822471) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2822490..2822496) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2822533..2823357) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2822533..2823357) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2822541) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2822690) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2822717..2822722 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2822738..2822756 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2822740 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2823371..2824039) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2823371..2824039) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2824032..2825057) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2824032..2825057) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2825058..2825162) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2825163..2825269) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2825163..2825269) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2825232 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2825296..2825315) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2825308) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2825310..2825383) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2825331..2825338) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2825384..2825728) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2825384..2825728) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2825729..2825834) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2825835..2826155) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2825835..2826155) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2826157..2826597) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2826157..2826597) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2826597..2826833) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2826597..2826833) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2826609) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2826848) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2826853..2826864) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2826879..2826885) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2826889..2827272) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2826889..2827272) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2827299..2827318) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2827310) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2827331..2827338) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2827339..2827695) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2827339..2827695) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2827718..2827737) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2827728) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2827751..2827756) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2827806..2829590) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2827806..2829590) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2827816) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2829605..2830780) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2829605..2830780) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2830791..2833160) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2830791..2833160) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2832579..2832584 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2832599..2832617 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2832602 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2833228..2833247) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2833231) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2833239..2833505) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2833261..2833268) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2833286..2833292 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2833307..2833318 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2833329 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2833335..2833481 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2833335..2833481 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2833482..2834508 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2833506..2834414) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2833506..2834414) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2834415..2834937) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2834509..2834754 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2834509..2834754 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2834767..2835099 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2834767..2835099 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2834920..2834939) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2834937) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2834953..2834962) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2835088 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2835160..2835167 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2835181..2835200 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2835192 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2835258..2835725 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2835258..2835725 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2835722..2837347 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2835722..2837347 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2837332 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2837383..2837766) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2837383..2837766) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2837785..2838174) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2837785..2838174) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2838196..2838525) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2838196..2838525) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2838560..2838579) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2838567..2838574 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2838574) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2838589..2838608 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2838593..2838600) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2838599 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2838659..2839546 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2838659..2839546 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2839566..2839853) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2839566..2839853) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2839578) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2839878..2840705) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2839878..2840705) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2839894) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2840706..2840843) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2840828..2840847) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2840843) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2840863..2840866) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2840923..2841360) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2840923..2841360) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2841384..2841402) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2841390) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2841418..2841423) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2841470..2842978) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2841470..2842978) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2841491) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2842969..2843265) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2842969..2843265) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2843288..2843307) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843304) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2843322..2843325) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2843342..2843347 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2843359..2843378 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2843359 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2843399..2844241 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2843399..2844241 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2843771..2843777 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2843792..2843803 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2843800 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2844268..2844275 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2844284 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2844287..2844306 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2844331..2844792 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2844331..2844792 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2844768 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2844836..2846212) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2844836..2846212) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2844844) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2846213..2846384) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2846365..2846384) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2846384) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2846395..2846402) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2846445..2846464) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2846455..2846474 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2846457 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2846463) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2846465..2847528) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2846479..2846486) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2846490..2847167 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2846490..2847167 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2847164..2848519 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2847164..2848519 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2847618..2848546) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2848487 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2848547..2848711) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2848547..2848711) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2848735..2848742 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2848756..2848775 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2848760..2848779) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2848766..2848878 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2848766 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2848773) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2848775..2849053) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2848793..2848800) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2848879..2849754 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2848879..2849754 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2849043..2849062) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2849053) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2849055..2849596) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2849076..2849083) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2849588..2849606) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2849596) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2849598..2849727) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2849619..2849626) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2849729 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2849772) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2849790..2851178) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2849790..2851178) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2851202) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2851207..2851225) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2851236..2851244) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2851245..2851430) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2851245..2851430) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2851434 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2851474..2851493) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2851483..2851489 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2851488) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2851503..2851514 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2851506 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2851509..2851512) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2851548..2852996 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2851548..2852996 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2852544..2855187) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2852965..2854062 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2852965..2854062 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2854059..2855180 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2854059..2855180 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2855188..2855823) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2855188..2855823) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2855801..2856883) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2855801..2856883) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2856880..2857605) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2856880..2857605) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2857639..2858511) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2857639..2858511) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2858530..2858549) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2858550) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2858564..2858567) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2858612..2859289) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2858612..2859289) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2858628) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2859316..2859696) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2859316..2859696) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2859719..2859738) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2859739) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2859753..2859756) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2859858..2861126) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2859858..2861126) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2859871) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2861160..2861179) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2861171) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2861194..2861201) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2861297) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2861303..2861884) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2861303..2861884) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2861907..2863235) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2861907..2863235) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2863235..2864296) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2863235..2864296) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2864259..2865203) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2864259..2865203) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2865204..2865473) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2865312..2865442) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2865312..2865442) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2865450..2865469) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2865473) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2865475..2866402) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2865485..2865492) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2865535..2865542 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2865557..2865576 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2865561 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2865601..2866392 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2865601..2866392 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2866263 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2866373 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2866430..2867308) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2866430..2867308) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2866447) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2867332..2867350) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2867351) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2867364..2867370) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2867380..2869122) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2867380..2869122) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2869119..2869832) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2869119..2869832) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2869863..2869882) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2869881) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2869985..2870224) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2869985..2870224) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2869992) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2870220..2870238) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2870228..2870758) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2870228..2870758) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2870229) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2870253..2870259) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2870761..2870780) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870768) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2870773..2871111 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2870773..2871111 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2870795..2870802) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2870811..2870830) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870823) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2870845..2870851) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2870857..2870957 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2870917 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2871085..2871185 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2871145..2871231 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2871145 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2871232..2872389 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2871232..2872389 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2872375 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2872450..2872860 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2872450..2872860 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2872859 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2872894..2874123) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2872894..2874123) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2872911) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2874116..2874805) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2874116..2874805) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2874789..2875982) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2874789..2875982) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2876026..2876045) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2876039) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2876060..2876067) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2876153..2876962) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2876153..2876962) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2876170) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2876309..2876318 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2876331..2876350 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2876335 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2876978..2877988) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2876978..2877988) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2877988..2879142) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2877988..2879142) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2879075..2879094) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2879092) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2879106..2879113) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2879154..2879161 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2879176..2879195 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2879185 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2879240..2880187 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2879240..2880187 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2880163 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2880207 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2880361 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2880422..2881831) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2880422..2881831) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2880437) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2881249..2881253 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2881271..2881287 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2881278 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2881285..2882252 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2881933) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2881935..2882114) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2881935..2882114) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2882144..2882161) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2882155) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2882176..2882183) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2882209 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2882231..2882371) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2882231..2882371) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2882241) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2882399) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2882401..2882989) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2882404..2882415) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2882429..2882435) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2882461..2882468 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2882482 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2882484..2882503 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2882538..2883020 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2882538..2883020 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2883034..2883041 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2883055..2883074 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2883067 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2883120..2884973 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2883120..2884973 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2884959 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2885001..2885927) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2885001..2885927) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2885013) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2885939..2885958) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2885960) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2885974..2885977) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2885996..2886015 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2886005 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2886038..2886820 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2886038..2886820 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2886792..2887484 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2886792..2887484 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2887476 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2887515..2888345) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2887515..2888345) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2887521) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2888208..2888212 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2888228..2888232 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2888237 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2888347 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2888375..2888394) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2888393) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2888409..2888416) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2888501..2888507 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2888521 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2888522..2888540 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2888568..2889053 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2888568..2889053 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2889052 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2889097..2891109) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2889097..2891109) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2889105) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2890775..2890779) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2890777) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2891110..2891261) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2891238..2891256) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2891261) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2891364..2893079) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2891364..2893079) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2891371) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2893105..2894922) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2893105..2894922) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2894964..2894983) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2894973..2894980 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2894983) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2894986 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2894993..2895012 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2894996..2895003) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2895093..2897417) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2895093..2897417) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2895111) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2897437..2897444 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2897459..2897478 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2897460..2897475) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2897463 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2897465) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2897510..2897529) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2897519) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2897545..2897551) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2897555..2897574) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2897575) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2897588..2897596) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2897602) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2897615..2898223) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2897615..2898223) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2898262..2898281) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2898279) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2898297..2898301) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2898410..2898826) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2898410..2898826) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2898420) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2898831..2899499) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2898831..2899499) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2899551..2899570) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2899566) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2899577) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2899584..2899589) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2899619..2901727) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2899619..2901727) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2901719..2901820) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2901814..2901833) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2901820) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2901849..2901856) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2901887..2904295) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2901887..2904295) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2901909) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2901975) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2904296..2904378) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2904379..2904588) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2904379..2904588) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2904612..2904631) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2904633) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2904644..2904650) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2904662..2904967) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2904662..2904967) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2904931..2904950 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2904942 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2904981..2905000) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2905007) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2905014..2905020) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2905059..2905065 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2905080..2905098 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2905088 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2905095..2906171 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2905095..2906171 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2906158 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2906208..2906843) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2906208..2906843) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2906221) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2906844..2906941) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2906921..2906940) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2906941) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2906954..2906960) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2907003..2908898) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2907003..2908898) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2908949..2908960) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2908949) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2908975..2908981) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2909048) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2909061..2909462) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2909061..2909462) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2909459..2909818) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2909459..2909818) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2909815..2910387) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2909815..2910387) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2910425..2910444) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2910430) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2910458..2910465) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2910498..2911292) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2910498..2911292) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2911313..2911331) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2911325) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2911346..2911352) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2911358..2911377) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2911369) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2911371..2911436) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2911391..2911398) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2911478..2911837) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2911478..2911837) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2911481) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2911821..2911829) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2911831) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2911844..2911849) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2911889..2911908) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2911897) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2911899..2911963) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2911921..2911925) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2911963) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2911964..2911983) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2911998..2912005) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2912014..2912484) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2912014..2912484) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2912311..2912411 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2912371 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2912481 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2912529..2912548) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2912535) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2912537..2912628) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2912564..2912567) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2912629..2914968) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2912629..2914968) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2913729..2913732 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2913748..2913751 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2913757 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2914987..2915727) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2914987..2915727) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2915383..2915401) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2915395) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2915416..2915422) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2915755..2915773) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2915769) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2915857) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2915859..2916089) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2915859..2916089) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2916119..2916138) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2916140) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2916153..2916156) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2916178..2916184 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2916198..2916209 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2916199 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2916238..2917008 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2916238..2917008 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2916260..2916268 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2916279..2916297 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2916309 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2917048..2917281) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2917048..2917281) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2917372..2917379 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2917387 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2917391..2917410 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2917433..2917840 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2917433..2917840 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2917870..2918289 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2917870..2918289 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2918327..2918334 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2918348..2918367 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2918355 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2918381..2918707 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2918381..2918707 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2918708..2918792 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2918763..2918770 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2918783..2918801 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2918794 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2918832..2920532 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2918832..2920532 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2919548..2920541) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2920510 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2920572..2921252) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2920572..2921252) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2920586) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2920946..2920952 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2920967..2920985 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2920972..2923723 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2920972 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2921269..2922189) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2921269..2922189) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2922201..2922854) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2922201..2922854) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2922871..2924016) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2922871..2924016) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2924017..2924084) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2924084) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2924085..2924104) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2924115..2924119 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2924119..2924122) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2924135..2924153 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2924140 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2924235..2924239 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2924255..2924274 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2924258 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2924300..2924833 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2924300..2924833 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2924500..>2924899) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2924822 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2924899,2924906) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2924900..2924905 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2924906..2924981 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2924906..2924972) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2924977..2925666) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2924977..2925666) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2925017) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2925609..2925617 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2925631..2925650 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2925645 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2925684..2926595) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2925684..2926595) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2926615..2927268) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2926615..2927268) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2927291..2928433) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2927291..2928433) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2928477..2928496) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2928492) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2928511..2928514) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2928630..2928637 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2928650..2928669 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2928661 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2928697..2929254 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2928697..2929254 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2929255..2930019 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2929272..2929907) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2929272..2929907) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2929285) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2929948..2929966) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2929954) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2929982..2929988) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2929993..2930000 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2930012..2930031 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2930021 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2930057..2930671 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2930057..2930671 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2930657 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2930725..2930728 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2930743..2930762 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2930751 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2930803..2931501 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2930803..2931501 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2931474 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2931537..2933354) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2931537..2933354) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2931556) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2931727) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2933396..2933415) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2933400..2933419 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2933405 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2933409) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2933474..2933941 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2933474..2933941 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2933938 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2933986..2935278) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2933986..2935278) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2933996) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2935308..2936843) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2935308..2936843) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2936836..2937597) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2936836..2937597) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2937628..2938812) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2937628..2938812) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2938813..2939053) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2939053) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2939055..2939128) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2939067..2939086) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2939102..2939106) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2939129..2940136) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2939129..2940136) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2940055..2940058 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2940075..2940077 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2940077 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2940183..2941205) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2940183..2941205) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2940199) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2940227..2940228) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2941206..2941317) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2941243 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2941298..2941317) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2941317) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2941319..2941429) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2941331..2941338) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2941412..2941431) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2941427) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2941444..2941453) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2941503..2942897) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2941503..2942897) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2941517) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2942996..2943015) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2943010) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2943030..2943037) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2943037..2943044 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2943058..2943077 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2943064 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2943101..2944189 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2943101..2944189 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2944169 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2944238..2945248) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2944238..2945248) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2944245) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2945249..2945326) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2945316..2945335) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2945326) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2945349..2945356) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2945405..2946283) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2945405..2946283) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2945941..2945947 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2945962..2945973 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2945973 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2946317..2946324 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2946330..2946349) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2946335) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2946338..2946357 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2946340 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2946363..2946367) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2946383..2947300 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2946383..2947300 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2947289 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2947341..2948684) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2947341..2948684) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2948753..2948988) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2948753..2948988) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2948887) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2948989..2949085) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2949086..2950120) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2949086..2950120) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2950142..2950160) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2950148) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2950173..2950180) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2950228..2950950) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2950228..2950950) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2950244) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2950950..2952389) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2950950..2952389) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2951937..2951940 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2951957 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2951958..2951962 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2952111 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2952265 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2952266..2952267 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2952416..2953132) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2952416..2953132) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2953036..2953043 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2953057..2953059 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2953057 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2953130 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2953133..2953199) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2953196..2953215) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2953199) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2953230..2953237) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2953307..2953909) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2953307..2953909) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2953926..2955041) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2953926..2955041) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2955045..2955782) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2955045..2955782) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2955071..2955090) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2955085) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2955102..2955109) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2955783..2956688) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2955783..2956688) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(2956708..2956726) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2956719) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2956742..2956745) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2956897..2956904 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2956915..2956934 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2956922 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 2956972..2957781 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 2956972..2957781 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 2957817..2959028 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 2957817..2959028 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 2959015 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2959082..2960371) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(2959082..2960371) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(2960451..2962514) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(2960451..2962514) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(2962533..2963384) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(2962533..2963384) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(2963388..2964644) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(2963388..2964644) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(2964684..2965949) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(2964684..2965949) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(2965981..2966000) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2966003) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2966015..2966022) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2966090..2967082) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(2966090..2967082) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(2966124) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(2967212..2967261) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(2967235) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2967262..2967921) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(2967262..2967921) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(2967922..2968027) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(2968019..2968038) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2968028) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2968053..2968056) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2968080..2968087 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2968102..2968121 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2968102 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 2968105..2968210 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(2968111..2968128) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2968115) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2968136..2968142) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2968211..2969902 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 2968211..2969902 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 2969887 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2969929..2971239) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(2969929..2971239) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 2969932..2971002 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(2969941) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2971059..2971078 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2971059..2971317 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 2971059 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2971253..2971272) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2971268) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2971287..2971290) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2971318..2971536 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 2971318..2971536 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 2971515 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(2971543,2971550) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 2971544..2971549 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 2971581..2971584 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2971590 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2971601..2971619 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2971635..2973104 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 2971635..2973104 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 2973081 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 2973107..2973298 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 2973107..2973298 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 2973277 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2973325..2973810) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(2973325..2973810) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(2973833..2974144) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(2973833..2974144) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(2974196..2974288) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(2974196..2974288) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(2974328..2974347) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2974345) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2974361..2974368) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2974419..2975102) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(2974419..2975102) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(2974437) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(2975118..2976473) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(2975118..2976473) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(2976485..2976500) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2976501) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2976512..2976521) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2976775..2976782 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2976796..2976815 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2976799 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2976821..2977011 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 2977012..2978433 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 2977012..2978433 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 2978427 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2978507..2980057 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 2978507..2980057 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 2980101..2980107 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2980121..2980132 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2980121 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 2980165..2981727 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 2980165..2981727 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 2981705 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2981717..2982406 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 2981717..2982406 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 2981756..2981763 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2981777..2981796 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2981786 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 2982387 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(2982485) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 2982488..2982823 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 2982488..2982823 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 2982823..2983143 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 2982823..2983143 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 2983144..2983334 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(2983179..2983691) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(2983179..2983691) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 2983311 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2983727..2983738) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2983733) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2983753..2983759) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2983806..2983942) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(2983849) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(2983943..2985286) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(2983943..2985286) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(2985315..2985334) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2985323) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2985347..2985356) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2985348..2985353 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2985369..2985387 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2985372 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2985581..2985590 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2985599 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2985604..2985623 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2985642..2986604 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 2985642..2986604 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 2986605..2986858 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(2986885) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(2986889..2986964) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(2986889..2986964) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(2986991..2987010) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2987012) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2987026..2987029) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2987095..2987101 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2987111..2987186 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 2987111 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2987116..2987135 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2987163..2987170 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2987184..2987203 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2987188 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 2987234..2987827 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 2987234..2987827 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 2987816 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 2987861..2988259 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(2987873..2988553) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(2987873..2988553) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(2987897) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(2988550..2990235) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(2988550..2990235) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(2990228..2992501) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(2990228..2992501) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(2992479..2993363) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(2992479..2993363) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(2993369..2994205) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(2993369..2994205) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(2994206..2995513) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(2994206..2995513) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 2994571..2994580 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2994593..2994612 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2994597 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2995553..2996806) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(2995553..2996806) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(2996807..2996901) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(2996902..2998671) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(2996902..2998671) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 2998592..2998597 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2998613..2998631 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2998623 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2998709..2998728) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2998722) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2998741..2998748) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2998784..2999734) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(2998784..2999734) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(2999749..2999767) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2999762) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2999779..2999787) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2999868) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2999940..3000515) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(2999940..3000515) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(2999952) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3000558..3000577) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3000564..3000571 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3000574) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 3000581 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3000584..3000603 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3000592..3000599) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3000632..3000952 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 3000632..3000952 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 3000933 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3000979) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(3000979..3002571) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(3000979..3002571) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(3002590..3003183) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(3002590..3003183) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(3003225..3003244) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3003238) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3003259..3003263) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3003309..3003314 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3003330..3003348 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003331 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3003504..3003511 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3003525..3003544 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003529 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 3003566..3004543 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 3003566..3004543 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 3004515 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3004581..3006521) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(3004581..3006521) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(3004605) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(3006496..3007275) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(3006496..3007275) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(3007276..3007357) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3007358..3008428) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(3007358..3008428) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(3008422..3009135) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(3008422..3009135) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(3009181..3009200) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3009193) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3009195..3009456) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3009213..3009216) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3009216..3009223 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3009234..3009253 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3009239 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3009282..3009491 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 3009282..3009491 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 3009469 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3009501) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3009527..3010291) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(3009527..3010291) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(3009549) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3010292..3010549) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(3010292..3010549) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(3010573..3011523) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(3010573..3011523) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(3011546..3012499) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(3011546..3012499) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(3012501..3013388) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(3012501..3013388) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(3013413..3013889) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(3013413..3013889) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(3013909..3013928) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3013923) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3013944..3013948) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3013967..3013986) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3013980) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3014001..3014004) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3014056..3014206) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3014099) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(3014207..3015157) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(3014207..3015157) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(3015158..3015245) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3015234..3015253) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3015245) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3015247..3015338) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3015268..3015271) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3015286..3015292 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3015306..3015324 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3015320 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 3015321..3018707 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3015363..3016784) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(3015363..3016784) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(3015383) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(3015507) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 3016411..3016415 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3016421 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3016700..3016704 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3016707 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3016785..3016982) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3016905 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3016970..3016989) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3016982) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(3017001..3017008) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3017165..3018619) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(3017165..3018619) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(3017185) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(3018620..3018744) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3018665 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3018745..3020514) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(3018745..3020514) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(3020515..3020589) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3020578..3020597) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3020589) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(3020679..3021038) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(3020679..3021038) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(3020699) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3021053..3022963) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(3021053..3022963) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(3022965..3023690) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(3022965..3023690) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(3023691..3023779) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3023779..3023798) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023779) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3023781..3023910) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3023814..3023817) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3023936..3024565) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(3023936..3024565) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(3023955) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(3024562..3025320) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(3024562..3025320) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(3025317..3026054) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(3025317..3026054) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(3026051..3026689) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(3026051..3026689) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 3026547..3026647 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3026607 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3026690..3027274) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(3026690..3027274) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(3027271..3028554) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(3027271..3028554) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(3028551..3029192) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(3028551..3029192) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(3029185..3030360) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(3029185..3030360) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(3030361..3030438) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3030404..3030410 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3030422..3030441 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3030422..3030441) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3030435 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3030438) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3030454..3030461) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3030570..3030589 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3030577 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 3030611..3031363 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 3030611..3031363 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 3031364..3031602 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3031385..3031396) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3031391) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3031411..3031417) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3031603..3032268 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 3031603..3032268 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 3032239 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3032288..3032806) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(3032288..3032806) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(3032322) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3032810..3033460) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(3032810..3033460) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3033457..3034395) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3033457..3034395) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3034419..3035228) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3034419..3035228) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3035242..3036174) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3035242..3036174) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3036216..3036235) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3036222) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3036251..3036256) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3036291..3036298 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3036310 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3036313..3036330 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3036356..3037546 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3036356..3037546 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3037344..3037350 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3037365 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3037366..3037384 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3037543..3038271 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3037543..3038271 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3038289..3039020 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3038289..3039020 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3039040..3042909) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3039040..3042909) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3039162) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3042929..3042940) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3042936) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3042955..3042961) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3042999..3043005 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3043019..3043038 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3043024 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3043074..3043547 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3043074..3043547 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3043548..3043655 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3043588..3044805) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3043588..3044805) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3043601) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3043627..3043632 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3043647..3043658 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3043657..3043942 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3043657 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3043899 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3044821..3045567) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3044821..3045567) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3045568..3045754) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3045740..3045759) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3045754) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3045773..3045780) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3045888..3045895 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3045910..3045929 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3045922 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3045923..3045992 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3045993..3046502 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3045993..3046502 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3046398..3047736) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3046439) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3046523..3047734 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3046523..3047734 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3047732 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3047762..3048121) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3047762..3048121) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3047777..3048493 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3047781) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3048123..3048320) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3048123..3048320) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3048325..3049422) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3048325..3049422) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3049447..3049773) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3049447..3049773) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3049826..3049841) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3049841) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3049843..3050333) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3049853..3049862) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3049921..3049924 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3049939..3049958 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3049949 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3049991..3050221 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3049991..3050221 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3050324..3050343) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3050334) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3050359..3050363) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3050420..3050902) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3050420..3050902) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3050428 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3050443) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3050575) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3050583..3050586) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3050663..3050667) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3050663) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3050683..3050686) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3050903..3051036) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3051064..3053937) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3051064..3053937) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3051081) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3053945..3055930) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3053945..3055930) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3055964..3055983) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3055976) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3055978..3056063) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3055995..3056002) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3056108) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3056116..3056346) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3056116..3056346) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3056373..3056392) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3056383) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3056385..3056449) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3056406..3056413) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3056426..3056444) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3056447) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3056459..3056465) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3056515) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3056541..3056641) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3056581) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3056663..3056670 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3056684..3056703 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3056701 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3056793..3059288 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3056793..3059288 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3059303..3059307 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3059321 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3059364..3059933 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3059364..3059933 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3059964..3061298 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3059964..3061298 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3061279 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3061346..3062539) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3061346..3062539) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3061355) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3061420) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3062540..3062617) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3062543) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3062618..3062956) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3062618..3062956) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3062931..3063047) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3062931..3063047) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3063048..3063137) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3063119..3063137) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3063137) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3063139..3063219) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3063151..3063156) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3063205..3063223) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3063219) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3063237..3063244) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3063356..3064798) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3063356..3064798) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3063445) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3064844..3064855) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3064855) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3064870..3064876) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3064938..3065828) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3064938..3065828) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3064955) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3065821..3066507) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3065821..3066507) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3066508..3066640) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3066630..3066649) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3066640) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3066664..3066667) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3066741..3067079) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3066741..3067079) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3066742) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3067106..3067125) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3067119) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3067128..3068012) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3067128..3068012) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3067139..3067146) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3068000..3068019) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3068021) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3068034..3068041) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3069169..3069240), complement(3068139..3069167)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3068139..3069240) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3068155) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3069241..3069309) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3069310..3071835) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3069310..3071835) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3071836..3071916) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3071906..3071925) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3071916) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3072003..3072572) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3072003..3072572) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3072011) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3072539..3072545 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3072558..3072577 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3072565 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3072599..3072617) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3072607) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3072609..3072729) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3072629..3072637) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3072713..3072731) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3072729) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3072747..3072752) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3072763..3073140) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" /label="yvzG CDS" gene complement(3072763..3073140) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /label="yvzG gene" CDS complement(3073150..3073491) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" /label="fliT CDS" gene complement(3073150..3073491) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /label="fliT gene" CDS complement(3073488..3073889) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" /label="fliS CDS" gene complement(3073488..3073889) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /label="fliS gene" CDS complement(3073911..3075407) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" /label="fliD CDS" gene complement(3073911..3075407) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /label="fliD gene" CDS complement(3075425..3075754) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" /label="yvyC CDS" gene complement(3075425..3075754) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /label="yvyC gene" downshifts 3075751 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3075776..3075794) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3075791) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3075793..3075897) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3075808..3075815) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3075886..3075905) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3075897) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="upshifts" CDS complement(3075987..3076901) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" /label="hag CDS" gene complement(3075987..3076901) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /label="hag gene" downshifts complement(3076007) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature complement(3076902..3077010) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3076968..3076969 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3076978..3076992 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3076987 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3076989..3077007) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3077010) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="upshifts" promotor_-35 complement(3077020..3077027) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3077046..3077270) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" /label="csrA CDS" gene complement(3077046..3077270) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /label="csrA gene" downshifts complement(3077085) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3077264..3077695) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" /label="fliW CDS" gene complement(3077264..3077695) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /label="fliW gene" CDS complement(3077716..3078291) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" /label="yviE CDS" gene complement(3077716..3078291) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /label="yviE gene" CDS complement(3078338..3079234) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" /label="flgL CDS" gene complement(3078338..3079234) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /label="flgL gene" downshifts complement(3078361) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" misc_feature 3078650..3078653 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3078659 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3079245..3080768) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " /label="flgK CDS" gene complement(3079245..3080768) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /label="flgK gene" CDS complement(3080787..3081269) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3080787..3081269) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3081285..3081551) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3081285..3081551) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3081552..3081631) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3081632..3082051) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3081632..3082051) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3082090..3082108) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3082101) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3082122..3082129) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3082125..3082847) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3082125..3082847) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3082811..3083107) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3082811..3083107) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3083133..3083152) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3083146) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3083163..3083170) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3083167..3084558) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3083167..3084558) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3084572..3084591) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3084587) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3084605..3084612) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3084664..3085509) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3084664..3085509) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3084675) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3084926..3084933 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3084947..3084966 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3084957..3086689 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3084957 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3085536..3085555) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3085555) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3085570..3085573) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3085607..3086296) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3085607..3086296) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3085621) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3086297..3086378) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3086379..3087536) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3086379..3087536) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3087537..3087664) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3087584..3087587 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3087602..3087621 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3087613..3087699 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3087613 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3087658..3087677) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3087664) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3087681..3087689 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3087688..3087695) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3087701 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3087703..3087711 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3087753..3088406 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3087753..3088406 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3088109..3088701) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3088406..3089581 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3088406..3089581 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3088697..3088715) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3088706) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3088729..3088735) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3089553 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3089654..3090730) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3089654..3090730) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3089670) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3089716..3089725 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3089739..3089758 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3089747..3090980 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3089747 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3090731..3090813) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3090801..3090820) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3090813) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3090832..3090838) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3090875..3092068) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3090875..3092068) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3090905) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3092097..3092855) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3092097..3092855) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3092879..3093559) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3092879..3093559) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3093588..3095054) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3093588..3095054) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3095055..3095138) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3095139..3096524) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3095139..3096524) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3096586..3097755) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3096586..3097755) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3097752..3099203) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3097752..3099203) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3099259..3099408) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3099259..3099408) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3099353..3099892) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3099353..3099892) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3099948..3099965) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3099952) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3100119..3101609) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3100119..3101609) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3100141) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3101648..3103765) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3101648..3103765) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3103789..3104097) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3103789..3104097) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3104003 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3104093..3104097 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3104106..3104120 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3104107..3104125) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3104113 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3104139..3104146) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3104142) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3104163..3104171 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3104185..3104198 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3104203 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3104281..3105201 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3104281..3105201 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3105191 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3105241..3106383) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3105241..3106383) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3105265) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3106422..3106441) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3106436) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3106456..3106459) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3106512..3106516 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3106532..3106551 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3106533..3106628 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3106534 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3106629..3107507 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3106629..3107507 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3107508..3108599 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3107577..3107932) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3107841..3108059 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3107841..3108059 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3107933..3108016) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3107933..3108016) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3108017..3108208) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3108209..3110911) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3108209..3110911) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3110912..3111034) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3110933..3110939 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3110954..3110972 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3110959..3113791 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3110959 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3111035..3112375) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3111035..3112375) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3112416..3112622) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3112416..3112622) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3112623..3113496) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3113490..3113509) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3113496) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3113498..3113737) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3113522..3113528) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3113719..3113737) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3113737) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3113751..3113758) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3113760..3113767 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3113779..3113798 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3113793..3113923 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3113793 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3113865..3113965 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3113925 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3113929..3114525 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3113929..3114525 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3114123 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3114564..3116147) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3114564..3116147) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3114607 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3116167..3116994) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3116167..3116994) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3116995..3117059) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3117055..3117074) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3117059) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3117061..3117158) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3117090..3117093) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3117159..3119399) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3117159..3119399) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3119399..3121420) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3119399..3121420) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3120162..3120171 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3120184..3120199 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3120195 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3121421..3121580) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3121581..3121970) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3121581..3121970) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3121971..3122105) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3122089..3122108) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122105) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3122119..3122126) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3122260..3122266 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3122277..3122369 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3122277 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3122278..3122297 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3122370..3123140 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3122370..3123140 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3122497..3122845) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3122849..3122860) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122853) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3122875..3122881) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3123165 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3123173..3124318 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3123173..3124318 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3124306 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3124360..3124367 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3124382..3124401 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3124392 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3124438..3125766 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3124438..3125766 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3125761 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3125822) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR 3125846..3125847 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_002" downshifts 3125870 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3125923..3127164) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3125923..3127164) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3125942) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3127186..3127204) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3127208) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3127217..3127224) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3127305..3127472) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3127305..3127472) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3127332) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3127487..3128629) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3127487..3128629) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3128648..3129097) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3128648..3129097) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3128791..3128797 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3128805 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3128811..3128829 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3128818..3131027 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3129112..3130293) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3129112..3130293) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3131007..3131014 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3131029 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3131030..3131049 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3131050) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3131055..3131069) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3131077..3131081) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3131077..3132057 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3131077..3132057 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3131906..3131913 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3131927..3131946 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3131942 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3132059..3132940 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3132059..3132940 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3132937..3133332 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3132937..3133332 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3133348..3134829 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3133348..3134829 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3134831..3135799 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3134831..3135799 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3135811..3136728 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3135811..3136728 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3136737..3136743 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3136758..3136776 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3136760 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3136810..3137346 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3136810..3137346 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3137329 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3137374..3137484 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3137453..3137459 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137474..3137485 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137486 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3137502..3137798 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3137502..3137798 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3137799..3138451 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3137838..3138365) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3137838..3138365) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3137848) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3138385..3138404) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3138398) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3138409 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3138418..3138425) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3138464) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3138465..3139232) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3138465..3139232) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3139294..3141006) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3139294..3141006) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3139905..3139914 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3139928..3139947 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3139928 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3141060..3141079) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3141065) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3141085..3141092 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3141094..3141098) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3141106..3141125 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3141116 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3141164..3142072 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3141164..3142072 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3142140..3142148 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3142150..3142282 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3142150 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3142162..3142181 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3142283..3143611 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3142283..3143611 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3143602 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3143668..3144345) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3143668..3144345) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3143678) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3144405..3145547) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3144405..3145547) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3145584..3145603) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3145592) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3145594..3145674) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3145617..3145625) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3145675..3146763) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3145675..3146763) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3146764..3146877) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3146819..3146828 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146841..3146860 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146854 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3146877) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3146881..3146895) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3146904..3146908) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3146904..3147491 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3146904..3147491 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3146992..3147471 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3146992..3147471 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3147375..3147572) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3147408 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3147418) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3147477 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3147556 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3147571..3147590) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3147577) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3147599..3147606 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3147603..3147612) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3147621..3147640 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3147627 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3147665..3148282 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3147665..3148282 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3148283..3148383 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3148340 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3148409..3148418 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3148430..3148445 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3148431 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3148460..3148795 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3148460..3148795 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3148751..3148769) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3148760) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3148784..3148789) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3148794 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3148800..3150377) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3148800..3150377) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3148839..3150550 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3150528..3150535 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3150546..3150565 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3150552 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3150591..3151067 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3150591..3151067 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3151081..3151674 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3151081..3151674 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3151671..3152207 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3151671..3152207 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3152188 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3152234..3152455) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3152234..3152455) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3152402 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3152409..3152410 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3152452..3152997) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3152452..3152997) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3153014..3153021 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3153036..3153055 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3153040 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3153120..3154001 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3153120..3154001 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3154086..3154802) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3154086..3154802) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3154106) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3154812..3155276) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3154812..3155276) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3155266..3157074) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3155266..3157074) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3157093..3157353) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3157093..3157353) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3157363..3157785) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3157363..3157785) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3157786..3157868) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3157860..3157879) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3157868) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3157892..3157899) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3158002..3158127) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3158002..3158127) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3158045..3158176) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3158088) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3158177..3158962) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3158177..3158962) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3158963..3159078) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3159071..3159090) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3159078) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3159104..3159111) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3159154..3160476) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3159154..3160476) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3159166) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3160510) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3160512..3160637) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3160512..3160530) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3160546..3160551) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3160617..3160636) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3160637) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3160671..3161435) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3160671..3161435) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3161454) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3161488..3162201) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3161488..3162201) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3161505) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3162191..3162937) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3162191..3162937) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3162969..3162988) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3162981) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3163005..3163008) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3163171..3163314) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3163171..3163314) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3163192) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3163315..3163400) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3163390..3163401) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3163400) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3163402..3163632) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3163439..3163443 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3163459..3163478 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3163468 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3163518..3165128 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3163518..3165128 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3163620..3163638) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3163632) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3163634..3163808) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3163652..3163659) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3163795..3163814) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3163808) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3163828..3163836) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3165115..3167883 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3165115..3167883 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3167932) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3168009..3168866) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3168009..3168866) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3168872..3169648) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3168872..3169648) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3169674..3169693) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3169696) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3169698..3169770) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3169708..3169715) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3169772..3169871) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3169815) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3169872..3170213) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3169872..3170213) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3170235..3170254) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3170254) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3170268..3170275) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3170290..3170673) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3170290..3170673) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3170695..3170714) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3170702..3170721 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3170706 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3170715) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3170729..3170736) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3170796..3170815 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3170799 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3170848) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3170848..3171258 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3170848..3171258 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3171259..3171342 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3171300 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3171398..3171706) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3171398..3171706) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3171399) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3172050..3172886 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3172050..3172886 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3172266..3172273 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3172288..3172307 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3172291 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3172885 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3172933..3173325) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3172933..3173325) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3172939) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3173398..3173823) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3173398..3173823) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3173884..3173903) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3173900) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3173902..3173986) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3173918..3173925) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3173965 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3173968..3173987 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3173978..3173997) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3173986) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3173988..3175072) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3174011..3174016) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3174015..3175079 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3174015..3175079 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3175080..3175964 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3175102..3175911) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3175102..3175911) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3175117) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3175945..3176757) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3175945..3176757) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3176758..3176837) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3176788..3176795 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3176809..3176828 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3176818 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3176831..3176849) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3176837) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3176863..3176870) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3176920..3177921) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3176920..3177921) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3176926) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3177976..3177995) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3178000) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3178002..3178086) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3178087..3178368) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3178087..3178368) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3178383..3178493) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3178383..3178493) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3178524..3178542) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3178546) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3178558..3178563) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3178639..3178645 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3178659..3178678 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3178675 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3178718..3179131 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3178718..3179131 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3179153..3180343 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3179153..3180343 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3180434..3181840) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3180434..3181840) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3180731) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3181873..3181892) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3181891) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3181907..3181910) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3181946..3183418) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3181946..3183418) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3183599..3184957) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3183599..3184957) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3183613) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3184957..3185526) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3184957..3185526) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3185545..3185556) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3185563) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3185570..3185576) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3185633..3185800) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3185633..3185800) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3185710..3186174) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3185710..3186174) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3186204..3186223) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3186209) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3186237..3186244) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3186375..3186378 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3186393..3186412 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3186397 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3186456..3187670 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3186456..3187670 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3187286..3187304) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3187287) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3187318..3187325) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3187536..3187542 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3187556..3187575 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3187558 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3187682..3188032 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3187682..3188032 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3188025 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3188084..3188092 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3188106..3188114 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3188113 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3188155..3188164 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3188177..3188192 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3188181 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3188213..3188794 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3188213..3188794 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3188311..3188330) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3188321) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3188344..3188352) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3188775 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3188835..3189257) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3188835..3189257) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3188854) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3189292..3189307) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3189311) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3189320..3189329) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3189368..3190219) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3189368..3190219) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3189377) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3189619) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3189856..3189858 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3189875..3189894 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3189876..3190222 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3189876 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3190214..3190217 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3190224..3190359 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3190224 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3190253) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3190259..3190268) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3190360..3190851 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3190360..3190851 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3190589..3190594 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3190610..3190628 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3190621 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3190712..3191620) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3190848..3191366 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3190848..3191366 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3191171 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3191369 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3191525..3191656 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3191525..3191656 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3191653..3192087) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3191653..3192087) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3191665) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3192136..3192155) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3192143) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3192145..3192442) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3192170..3192177) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3192216..3192220 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3192237..3192256 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3192249..3192329 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3192250 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3192330..3193778 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3192330..3193778 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3192442) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3192443..3192461) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3192444..3192787) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3192477..3192483) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3192765..3192783) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3192787) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3192799..3192804) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3193767 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3193799..3194572) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3193799..3194572) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3193821) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3194647..3194650 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3194666..3194685 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3194670 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3194717..3195100 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3194717..3195100 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3195087 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3195135..3195776) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3195135..3195776) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3195185) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3195844..3196245) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3195844..3196245) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3196294..3196313) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3196304) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3196306..3196379) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3196328..3196333) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3196380..3198089) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3196380..3198089) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3198086..3198460) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3198086..3198460) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3198457..3198774) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3198457..3198774) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3198775..3198859) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3198859) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3198861..3198874) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3198861..3198954) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3198955..3199119) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3198955..3199119) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3199042..3199060) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3199054) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3199072..3199080) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3199120..3199291) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3199292..3199474) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3199292..3199474) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3199475..3199621) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3199609..3199628) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3199621) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3199623..3199737) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3199643..3199650) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3199724,3199726) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3199751 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3199754..3199758 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3199771..3199959) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3199771..3199959) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3199782) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3199949 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3199985..3200003) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3199996) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3200017..3200023) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3200032..3200532) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3200032..3200532) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3200568..3200587) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3200575) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3200601..3200607) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3200667..3201800) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3200667..3201800) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3200685) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3201827..3201846) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3201834) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3201897..3201915) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3201913) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3201929..3201936) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3201992..3203017) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3201992..3203017) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3202005) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3203033..3203821) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3203033..3203821) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3203847..3203866) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203853) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3203855..3204066) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3203880..3203887) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3204067..3204228) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3204067..3204228) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3204241..3204259) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3204261) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3204273..3204279) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3204322..3204996) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3204322..3204996) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3204337) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3205049..3205189) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3205049..3205189) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3205320..3206003) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3205320..3206003) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3206380..3206384 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3206389..3207420) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3206389..3207420) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3206399..3206418 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3206405) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3206417 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3207448..3207466) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3207461) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3207463..3207580) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3207482..3207487) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3207522..3207527 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3207539..3210199 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3207539 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3207543..3207561 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3207616..3208926) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3207616..3208926) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3207625) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3208950..3208969) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3208957) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3208960..3209700) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3208960..3209700) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3208983..3208992) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3209331) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3209333..3209341) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3209355..3209363) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3209455..3209470) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3209463) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3209483..3209492) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3209701..3209828) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3209829..3210059) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3209829..3210059) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3210060..3210322) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3210195..3210214 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3210201 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3210229..3210702 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3210229..3210702 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3210306..3210325) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3210322) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3210324..3210707) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3210340..3210343) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3210736..3211134) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3210736..3211134) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3210752) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3211126..3211144) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3211135) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3211158..3211164) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3211158..3212579) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3211158..3212579) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3212605..3213468) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3212605..3213468) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3213469..3213544) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3213545..3215053) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3213545..3215053) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3215070..3215615) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3215070..3215615) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3215612..3216124) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3215612..3216124) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3216125..3216286) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3216287..3216499) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3216287..3216499) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3216545..3217279) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3216545..3217279) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3217093..3217193 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3217153 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3217287..3217670) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3217287..3217670) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3217359..3217377) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3217361) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3217671..3217941) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3217903..3217912 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3217912 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3217917..3217936) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3217926..3217945 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3217941) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3217943..3218064) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3217949..3217956) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3218093..3218722) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3218093..3218722) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3218109) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3218766..3218785) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3218789) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3218800..3218807) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3218857..3220104) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3218857..3220104) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3218880) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3220146..3220165) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3220163) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3220165..3220249) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3220180..3220185) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3220294) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3220311..3220853) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3220311..3220853) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3220866..3221315) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3220866..3221315) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3221316..3221415) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3221407..3221426) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3221415) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3221440..3221447) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3221472..3221924) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3221472..3221924) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3221941..3221960) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3221959) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3221975..3221978) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3222000..3222557) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3222000..3222557) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3222584..3222602) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3222597) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3222618..3222623) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3222636..3223676) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3222636..3223676) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3222641) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3223677..3223741) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3223731..3223750) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3223741) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3223743..3223832) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3223766..3223770) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3223833..3224276) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3223833..3224276) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3224343..3225017) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3224343..3225017) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3224779..3224797) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3224786) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3224812..3224818) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3225049..3225066) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3225050) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3225082..3225087) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3225123 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3225127..3225146 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3225158..3225520 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3225158..3225520 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3225533) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3225537..3225824) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3225537..3225824) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3225825..3225883) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3225881..3225900) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3225884..3226750) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3225884..3226750) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3225897) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3225913..3225922) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3226752..3227822) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3226752..3227822) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3226755) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3227823 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3227850..3227869) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3227874) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3227876..3227987) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3227883..3227889) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3227919..3227938 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3227933 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3227948..3228334 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3227948..3228334 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3227969..3227987) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3227987) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3228001..3228008) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3228402..3228410 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3228421..3228439 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3228422 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3228456..3229010 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3228456..3229010 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3228940..3228944 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3228945 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3228989 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3229044..3230003) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3229044..3230003) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3229066) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3230041..3230059) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3230055) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3230074..3230080) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3230085..3231833) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3230085..3231833) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3230559..3230577) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3230567) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3230592..3230598) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3231834..3231924) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3231908..3231927) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3231924) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3231941..3231948) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3232067) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3232072..3232659) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3232072..3232659) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3232748..3232948) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3232748..3232948) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3232761) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3232949..3233026) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3233022..3233041) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233026) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3233055..3233062) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3233067..3234350) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3233067..3234350) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3234351..3234653) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3234381..3234542) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3234381..3234542) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3234633..3234652) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3234653) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3234668..3234672) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3234757..3235722) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3234757..3235722) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3234763) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3235339..3235348 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3235361..3235380 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3235369 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3235753..3237042) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3235753..3237042) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3237043..3237402) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3237421..3238059) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3237421..3238059) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3237447) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3238060..3238178) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3238179..3239036) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3238179..3239036) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3239037..3239163) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3239145..3239164) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3239163) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3239178..3239185) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3239217..3239591) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3239217..3239591) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3239631..3239649) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3239645) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3239647..3240286) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3239648..3239651 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3239660..3239668) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3239667..3239686 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3239680 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3239694..3239699 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3239715..3239734 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3239725 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3239757..3240278 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3239757..3240278 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3240221..3240224 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3240239..3240258 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3240253 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3240276..3240295) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3240286) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3240297 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3240310..3240317) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3240360..3241967) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3240360..3241967) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3240373) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3241968..3242155) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3242143..3242162) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3242155) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3242177..3242184) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3242209..3242730) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3242209..3242730) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3242265) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3242731..3242833) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3242814..3242833) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3242833) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3242835..3242912) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3242849..3242852) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3242913..3244052) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3242913..3244052) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3244049..3246166) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3244049..3246166) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3246167..3246225) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3246226..3246245) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3246239) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3246259..3246266) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3246265..3246271 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3246285..3246296 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3246290 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3246321..3247517 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3246321..3247517 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3246513..3247391) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3247381..3247399) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3247392) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3247415..3247420) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3247530..3248492 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3247530..3248492 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3248506..3248512 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3248527..3248545 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3248527 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3248573..3248845 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3248573..3248845 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3248579) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3248835 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3248880..3249286 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3248887..3249411) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3248887..3249411) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3248909) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3249421..3251148) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3249421..3251148) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3251182..3251201) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3251196) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3251215..3251221) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3251237..3252739) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3251237..3252739) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3252763..3252781) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3252781) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3252796..3252802) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3252826..3253198) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3252869) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3253225..3253896) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3253225..3253896) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3253243) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3253893..3254447) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3253893..3254447) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3254473..3255936) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3254473..3255936) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3255926..3259612) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3255926..3259612) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3259643..3259662) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3259667) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3259669..3259798) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3259808..3260284) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3259808..3260284) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3259843) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3260307..3260326) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3260319) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3260341..3260344) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3260391 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3260394..3260413 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3260428..3261147 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3260428..3261147 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3261131 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3261179..3261895) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3261179..3261895) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3261181) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3261251) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3261921..3261940) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3261933) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3261994..3263181) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3261994..3263181) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3263211..3263230) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3263229) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3263317..3264987) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3263317..3264987) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3263319) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3264984..3265412) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3264984..3265412) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3265480..3265494 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3265480..3265499) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3265487 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3265496) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3265516..3265519) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3265551..3265570) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3265563) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3265592,3265599) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3265593..3265598 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3265599..3268077 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3265600..3266976) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3265600..3266976) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3267015..3268370) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3267015..3268370) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3268406..3268425) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3268424) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3268438..3268447) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3268550..3268569 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3268551 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3268596) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3268600..3269745 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3268600..3269745 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3269604..3269608 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3269625..3269644 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3269632 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3269715) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3269729..3269848 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3269729..3269848 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3269833 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3269878..3269946 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3269947..3270420 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3269947..3270420 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3270409 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3270452..3271324) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3270452..3271324) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3270463) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3270529) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3271385..3272215) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3271385..3272215) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3272216..3272311) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3272299..3272318) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272310) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3272331..3272338) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3272356..3272361 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3272377..3272395 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3272379 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3272417..3274492 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3272417..3274492 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3274545) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3274669..3274784) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3274712) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3274785..3275303) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3274785..3275303) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3275317..3275976) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3275317..3275976) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3275999..3276002 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3276012..3276031) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3276017..3276036 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3276020 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3276030) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3276032..3276315) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3276046..3276053) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3276085..3276273 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3276085..3276273 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3276262 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3276316..3276735) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3276316..3276735) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3276785..3276804) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3276796) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3276819..3276826) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3276855..3278771) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3276855..3278771) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3278049..3278067) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278054) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3278084..3278088) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3278802) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3278825..3279046) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3278825..3279046) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3279078..3279299) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3279078..3279299) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3279331..3279593) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3279342 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3279374) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3279381..3279536) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3279381..3279536) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3279543..3279546 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3279555..3279568 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3279562 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3279570..3279589) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279593) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3279603..3279609) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3279616..3281016) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3279616..3281016) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3281016..3281486) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3281016..3281486) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3281442) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3281598..3282098) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3281598..3282098) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3281601) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3282134..3283435) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3282134..3283435) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3283459..3283478) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283473) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3283475..3283596) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3283494..3283496) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3283597..3283821) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3283597..3283821) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3283822..3283906) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3283895..3283914) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283905) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3283929..3283932) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3283972..3283978 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3283993..3284004 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3283994 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3284036..3284812 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3284036..3284812 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3284798 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3284900..3284907 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3284922..3284941 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3284926..3289152 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3284926 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3284956..3285846) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3284956..3285846) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3285846..3285946) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3285886) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3286014..3286859) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3286014..3286859) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3286177) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3286908..3287807) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3286908..3287807) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3287850..3287869) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3287853) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3287883..3287890) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3287954) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3287954..3288925) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3287954..3288925) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3288960..3288979) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3288985) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3288995..3288999) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3289073..3289084) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3289076) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3289098..3289104) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3289147..3289166 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3289154 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3289195..3289959 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3289195..3289959 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3289946 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3289966,3289973) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3289967..3289972 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3289973..3290025 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3289975..3291213) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3289975..3291213) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3291255..3291274) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3291267) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3291286..3291293) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3291423..3292835) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3291423..3292835) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3291430) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3292835..3294535) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3292835..3294535) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3293504..3293520) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3293516) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3294609..3296156) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3294609..3296156) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3294616) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3296200) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3296202..3296382) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3296203..3296221) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3296383..3297657) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3296383..3297657) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3297658..3297740) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3297740) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3297753..3297771) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3297833) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3297834..3298298) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3297834..3298298) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3298299..3298409) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3298391..3298410) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3298409) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3298425..3298432) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3298620) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3298622..3299077) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3298622..3299077) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3298712..3298731 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3298720 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3299070..3299921) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3299070..3299921) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3299935..3300882) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3299935..3300882) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3300882..3301622) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3300882..3301622) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3301640..3301645 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3301646 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3301647..3302666) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3301647..3302666) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3301660..3301678 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3302530..3302539 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3302552..3302567 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3302563 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3302669..3303391) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3302669..3303391) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3303384..3304505) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3303384..3304505) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3304505..3305374) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3304505..3305374) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3305375..3306544) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3305375..3306544) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3306565..3307989) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3306565..3307989) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3307994..3308764) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3307994..3308764) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3308799..3308818) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3308813) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3308832..3308841) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3308932..3308937 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3308953..3308971 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3308955..3309083 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3308955 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3309084..3309629 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3309084..3309629 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3309615 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3309673..3310044) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3309673..3310044) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3309691) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3310106..3311428) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3310106..3311428) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3311448..3311765) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3311448..3311765) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3311794..3311813) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3311805) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3311827..3311833) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3311868..3311875 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3311891..3311910 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3311894 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3311933..3313303 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3311933..3313303 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3313328..3314005) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3313328..3314005) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3313342) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3313832..3313851) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3313848) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3313867..3313872) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3314019..3314825) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3314019..3314825) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3314318..3314336) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3314332) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3314351..3314357) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3314854..3314873) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3314860) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3314889..3314896) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3314915..3315448) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3314915..3315448) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3315496..3316131) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3315496..3316131) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3316124..3316462) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3316124..3316462) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3316484..3316503) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3316495) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3316518..3316525) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3316546..3316549 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3316564..3316583 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3316564 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3316606..3317421 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3316606..3317421 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3317400 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3317476) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3317511..3317759) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3317511..3317759) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3317531) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3317777) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3317779..3317852) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3317787..3317793) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3317853..3319292) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3317853..3319292) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3319289..3320674) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3319289..3320674) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3320693..3320702) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3320707) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3320709..3320773) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3320752..3320769) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3320773) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3320785..3320792) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3320815..3320834) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3320833) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3320848..3320855) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3320914..3320917 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3320924 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3320932..3320951 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3320976..3321746 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3320976..3321746 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3321747..3322814 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3321785..3322615) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3321785..3322615) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3321786) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3322641..3322660) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3322647) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3322655..3322957) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3322655..3322957) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3322675..3322682) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3322958..3323096) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3323081..3323100) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3323096) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3323411..3323419 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3323430..3323448 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3323431 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3323487..3325907 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" /label="vpr CDS" gene 3323487..3325907 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /label="vpr gene" upshifts 3323645 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3323654..3323673 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3325895 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3325945..3326946) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3325945..3326946) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3326947..3327108) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3327120..3327869) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3327120..3327869) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3327153) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3327887..3327906) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3327904) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3327921..3327924) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3327975..3329156) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3327975..3329156) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3327989) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3329157..3329288) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3329282..3329297) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3329288) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3329309..3329318) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3329523..3329530 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3329541..3329651 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3329541..3329560 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3329541 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3329652..3329915 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3329652..3329915 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3329805 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3329921 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3329958..3330332) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3329958..3330332) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3329969) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3330334..3330948) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3330334..3330948) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3330962..3332911) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3330962..3332911) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3332175..3332194 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3332181 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3332605..3332705 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3332665 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3332775 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3332939..3333904) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3332939..3333904) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3333905..3333973) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3333960..3333979) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3333973) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3333975..3334160) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3333992..3333996) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3334091..3334096 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3334112..3334130 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3334117 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3334151..3334170) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3334160) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3334162..3334271) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3334185..3334189) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3334227 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3334256..3334275) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3334271) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3334291..3334295) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3334349..3334367) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3334354..3334360 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3334366) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3334375..3334393 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3334378 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3334383..3334388) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3334420..3334665 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3334420..3334665 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3334647 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3334736..3336277) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3334736..3336277) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3334765) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3336281..3337453) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3336281..3337453) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3337471..3337489) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3337493) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3337504..3337510) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3337534..3337917) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3337534..3337917) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3337935..3338606) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3337935..3338606) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3338628..3338647) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3338637) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3338663..3338666) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3338747..3338750 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3338765..3338784 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3338774..3338961 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3338774 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3338962..3339120 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3338962..3339120 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3339121..3339505 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3339486..3339491 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3339507..3339525 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3339507 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3339563..3339871 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3339563..3339871 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3339649) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3339653..3339753) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3339693) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3339868..3341409 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3339868..3341409 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3341400 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3341440..3342042) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3341440..3342042) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3341454) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3342043..3342324) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3342325..3343575) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3342325..3343575) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3342421) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3343594..3344751) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3343594..3344751) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3343667..3343686) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3343694) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3344748..3346193) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3344748..3346193) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3346227..3346246) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3346237) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3346260..3346267) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3346350..3347018) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3346350..3347018) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3346359) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3347015..3347833) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3347015..3347833) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3347841..3348746) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3347841..3348746) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3348481..3348500) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3348492) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3348787..3348806) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3348797..3348804 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3348808) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3348816 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3348818..3348837 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3348822..3348829) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3348852..3349238 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3348852..3349238 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3349220..3349897 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3349220..3349897 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3349869 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3349941..3349948 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3349959 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3349962..3349981 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3350001..3351200 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3350001..3351200 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3351234..3351431 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3351234..3351431 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3351410 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3351466..3352656) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3351466..3352656) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3351481) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3351565) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3352680..3352699) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3352696) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3352716..3352723 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3352732 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3352737..3352756 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3352777..3353157 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3352777..3353157 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3353055 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3353126 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3353195..3353872) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3353195..3353872) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3353202) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3353881..3353900) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3353906) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3353912..3353918) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3353949..3355283) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3353949..3355283) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3355331..3355349) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3355354) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3355448..3355455 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3355460 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3355469..3355487 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3355511..3357448 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3355511..3357448 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3356655..3356674) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3356656) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3356688..3356696) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3357438 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3357551..3357558 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3357573..3357592 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3357592 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3357804..3357811 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3357824..3357843 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3357824 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3357876..3359255 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3357876..3359255 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3358964..3360167) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3359309..3360151 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3359309..3360151 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3360202..3361062) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3360202..3361062) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3360212) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3361046 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3361084..3361102) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3361102) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3361117..3361123) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3361172..3361885) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3361172..3361885) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3361287..3361288 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3361308..3361325 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3361310 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3361913..3361924) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3361914) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3361939..3361945) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3361960..3361966 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3361981..3362000 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3361991 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3362036..3362551 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3362036..3362551 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3362552..3362758 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3362552..3362758 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3362718 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3362800..3364041 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3362800..3364041 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3364132..3364140 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3364151..3364169 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3364162 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3364197..3365564 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3364197..3365564 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3365541 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3365594..3366226) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3365594..3366226) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3365612) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3366262..3366277) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3366270) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3366290..3366298) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3366368..3367303) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3366368..3367303) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3366380) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3367047..3367056 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3367070..3367089 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3367074 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3367304..3367391) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3367374..3367393) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367391) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3367409..3367413) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3367436..3367448) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367436) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3367463..3367469) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3367466..3367600) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3367466..3367600) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3367547..3367554 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3367568..3367587 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3367577 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3367580..3367684 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3367679..3367688 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3367686 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3367700..3367715 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367722) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3367724..3367738) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3367750..3367899 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3367750..3367899 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3367917..3369428 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3367917..3369428 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3369425..3370612 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3369425..3370612 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3370629..3370865 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3370629..3370865 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3370865..3372043 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3370865..3372043 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3372044..3372133 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3372134..3372892 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3372134..3372892 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3372860 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3372894..3374121) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3372940..3372947 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3372961..3372980 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3372974 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3373033..3374124 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3373033..3374124 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3374026 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3374114 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3374158..3375486) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3374158..3375486) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3374166) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3375483..3375815) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3375483..3375815) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3375834..3377192) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3375834..3377192) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3377208..3377516) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3377208..3377516) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3377561..3377580) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3377577) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3377594..3377600) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3377645) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3377645..3379570) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3377645..3379570) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3378308..3378317 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3378331..3378350 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3378339 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3379643..3379660) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3379667) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3379675..3379682) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3379733..3379891) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3379733..3379891) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3379760) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3379920..3380510) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3379920..3380510) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3380538..3380556) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3380549) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3380570..3380576) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3380579..3380585 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3380601..3380619 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3380604 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3380639..3382282 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3380639..3382282 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3380776..3382325) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3382277 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3382327..3382418) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3382329..3382335 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3382343 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3382350..3382369 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3382370) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3382387..3383589 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3382387..3383589 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3382420..3383585) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3382463) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3383586..3384362) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3383586..3384362) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3384359..3385246) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3384359..3385246) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3385253..3385441) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3385253..3385441) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3385438..3385644) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3385438..3385644) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3385641..3385961) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3385641..3385961) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3385774..3385783 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3385796..3385815 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3385798 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3385954..3386490) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3385954..3386490) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3386518) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3386519..3386534) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3386546..3386555) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3386621..3386628 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3386642..3386661 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3386651 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3386702..3388075 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3386702..3388075 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3386982..3387524) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3387512..3387531) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3387524) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3387546..3387553) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3387910 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3388090..3388920) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3388090..3388920) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3388096) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3388939..3388957) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3388954) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3388972..3388978) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3388998) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3389000..3389019) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3389006..3390733) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3389006..3390733) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3389105) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3390730..3392433) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3390730..3392433) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3392433..3393449) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3392433..3393449) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3393323..3393341) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3393332) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3393357..3393362) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3393433..3394839) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3393433..3394839) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3394840..3395048) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3395031..3395050) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3395048) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3395050..3395158) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3395064..3395069) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3395155..3395174) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3395170) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3395188..3395195) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3395316..3395323 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3395333 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3395338..3395356 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3395395..3396747 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3395395..3396747 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3396346..3398828) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3396732 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3396823..3396842 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3396829 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3396869..3398557 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3396869..3398557 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3398555..3398564 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3398576..3398591 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3398580 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3398615..3398815 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3398615..3398815 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3398816..3399760 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3398829..3399668) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3398829..3399668) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3399694..3399712) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399712) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3399725..3399732) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3399727 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3399775..3400872) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3399775..3400872) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3399776) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3400905..3400924) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3400922) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3400924..3400992) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3400937..3400944) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3400993..3401886) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3400993..3401886) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3401913..3401932) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3401932) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3401946..3401953) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3401960..3401965 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3401981..3401999 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3401990 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3402007..3402013 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3402028..3402046 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3402034 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3402070..3403527 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3402070..3403527 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3402953..3402971) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3402968) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3402986..3402991) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3403508 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3403552 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3403569..3404405) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3403569..3404405) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3403587) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3404482..3404584) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3404482..3404584) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3404508) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3404610..3404629) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3404621) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3404623..3405364) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3404643..3404649) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3404701..3404708 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3404721..3404739 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3404730 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3404740..3404825 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3404801..3404808 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3404822..3404841 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3404827 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3404973..3405515 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3404973..3405515 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3405340..3405359) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3405364) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3405373..3405382) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3405505 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3405550..3405872 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3405590..3406609) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3405590..3406609) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3405608) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3406635..3406654) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3406649) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3406669..3406672) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3406724..3407230) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3406724..3407230) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3407236..3407255) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3407258) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3407260..3407263 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3407269..3407275) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3407278..3407297 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3407281 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3407360..3408235 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3407360..3408235 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3407610..3407698) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3407632) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3407658..3407758) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3407698) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3408313..3408786 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3408313..3408786 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3408804..3410024 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3408804..3410024 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3410011..3410667 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3410011..3410667 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3410665..3410670 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3410684..3410703 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3410687 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3410717..3411949 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3410717..3411949 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3410734) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3411934 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3411995..3412004 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3412017..3412032 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3412019..3412241 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3412019 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3412198 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3412252..3412258 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3412271..3412371 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3412271 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3412273..3412291 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3412350..3412357 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3412371..3412389 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3412373..3412470 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3412373 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3412471..3412734 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3412471..3412734 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3412498..3412501 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3412516..3412535 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3412528 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3412682 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3412726 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3412801..3412810 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3412816 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3412822..3412837 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3412863..3413351 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3412863..3413351 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3413356..3413363 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3413377..3413396 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3413387 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3413417..3413523 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3413417..3413523 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3413518 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3413606..3414739 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3413606..3414739 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3413879..3414122) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3414117..3414136) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3414126) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3414151..3414158) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3414745..3414752 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3414767..3414786 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3414773 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3414808..3414914 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3414808..3414914 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3414861 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3414915..3414991 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3414992..3416128 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3414992..3416128 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3416115 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3416181..3416954) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3416181..3416954) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3416191) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3416971..3417621) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3416971..3417621) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3417618..3418334) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3417618..3418334) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3418358..3419776) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3418358..3419776) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3418944..3418962) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3418963) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3418978..3418983) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3419777..3419861) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3419845..3419863) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3419861) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3419879..3419884) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3419930..3420778) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3419930..3420778) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3419940) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3420779..3420964) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3420953..3420972) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3420964) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3420966..3421691) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3420988..3420992) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3421126..3421133 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3421146..3421165 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3421155 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3421165..3421267 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3421165..3421267 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3421268..3421371 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3421343..3421349 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3421363..3421374 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3421373 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3421394..3422587 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3421394..3422587 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3421678..3421696) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3421694) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3421709..3421716) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3422363 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3422583 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3422629..3423057) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3422629..3423057) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3423058..3423300) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3423058..3423300) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3423301..3423364) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3423353..3423368) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3423364) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3423380..3423389) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3423397 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3423445..3423735) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3423445..3423735) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3423451) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3423760..3423779) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3423777) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3423785..3425845) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3423785..3425845) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3423793..3423800) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3425874..3425892) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3425878) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3425907..3425913) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3425938..3425943 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3425957 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3425959..3425977 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3425971..3426045 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3426046..3427326 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3426046..3427326 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3427327..3427466 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3427423 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3427484..3428212) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3427484..3428212) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3427501) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3428243..3428262) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3428254) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3428276..3428283) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3428400..3428507) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3428443) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3428508..3429341) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3428508..3429341) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3429372..3429391) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3429391) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3429405..3429412) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3429437..3430117) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3429437..3430117) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3430164..3430183) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3430173) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3430197..3430204) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3430265..3430268 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3430283..3430302 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3430283 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3430324..3431610 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3430324..3431610 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3431055..3431073) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3431063) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3431087..3431094) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3431581 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3431629..3433068) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3431629..3433068) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3431652) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3433092..3433111) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3433109) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3433150..3434298) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3433150..3434298) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3434325..3434341) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3434341) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3434343..3434427) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3434356..3434361) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3434428..3434616) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3434428..3434616) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3434647..3434778) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3434647..3434778) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3434790..3435251) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3434790..3435251) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3435267..3435563) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3435267..3435563) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3435591..3436079) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3435591..3436079) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3436097..3436549) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3436097..3436549) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3436550..3436618) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3436619..3436948) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3436619..3436948) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3436949..3437070) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3437071..3437487) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3437071..3437487) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3437538..3437906) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3437538..3437906) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3437900..3438370) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3437900..3438370) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3438371..3438695) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3438696..3439124) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3438696..3439124) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3439186..3446190) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3439186..3446190) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3446197..3446211 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3446211 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3446221..3446240) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3446236) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3446255..3446262) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3446352..3447287) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3446352..3447287) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3446573) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3447288..3447408) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3447439..3447885) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3447439..3447885) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3447453) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3447922..3447941) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3447929) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3447955..3447962) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3447988..3449397) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3447988..3449397) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3449420..3451249) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3449420..3451249) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3451241..3451341) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3451281) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3451283..3451475) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3451456..3451475) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3451475) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3451477..3451610) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3451488..3451495) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3451632..3451940) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3451632..3451940) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3451655) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3451986..3452429) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3451986..3452429) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3452426..3454135) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3452426..3454135) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3453297..3453316) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3453305) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3454155..3454424) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3454155..3454424) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3454436..3454801) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3454436..3454801) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3454802..3454867) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3454854..3454873) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3454867) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3454888..3454891) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3455108..3456517) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3455108..3456517) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3455131) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3456518..3456627) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3456651..3456815) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3456651..3456815) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3456700..3456718) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3456715) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3456729..3456737) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3457007..3457026) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3457023) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3457039..3457046) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3457055..3457062 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3457077..3457096 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3457080 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3457134..3457580 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3457134..3457580 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3457585 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3457693..3459219 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3457693..3459219 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3459216..3460874 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3459216..3460874 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3460887..3462152 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3460887..3462152 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3462145..3463104 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3462145..3463104 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3463105..3463179 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3463180..3464607 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3463180..3464607 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3464603 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3464651..3465952) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3464651..3465952) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3464668) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3465982..3467163) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3465982..3467163) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3467164..3467243) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3467244..3467915) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3467244..3467915) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3467864..3467867 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3467882 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3467883..3467902 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3467943..3467962) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3467958) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3467976..3467983) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3468021..3468962) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3468021..3468962) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3469007..3469026) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3469013) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3469015..3469095) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3469042..3469045) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3469096..3469923) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " /label="yxxB CDS" gene complement(3469096..3469923) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /label="yxxB gene" downshifts complement(3469895) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3469948..3469966) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3469961) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3469980..3469986) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3469996..3471108) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" /label="yxeR CDS" gene complement(3469996..3471108) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /label="yxeR gene" CDS complement(3471178..3472515) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" /label="yxeQ CDS" gene complement(3471178..3472515) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /label="yxeQ gene" CDS complement(3472512..3473654) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" /label="sndB CDS" gene complement(3472512..3473654) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /label="sndB gene" CDS complement(3473671..3474420) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" /label="yxeO CDS" gene complement(3473671..3474420) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /label="yxeO gene" CDS complement(3474433..3475107) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" /label="yxeN CDS" gene complement(3474433..3475107) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /label="yxeN gene" CDS complement(3475130..3475924) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" /label="yxeM CDS" gene complement(3475130..3475924) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /label="yxeM gene" promotor_-35 3475496..3475505 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3475517 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3475518..3475533 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3475949..3476446) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" /label="snaB CDS" gene complement(3475949..3476446) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /label="snaB gene" CDS complement(3476460..3477785) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" /label="yxeK CDS" gene complement(3476460..3477785) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /label="yxeK gene" promotor_-10 complement(3477862..3477881) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3477866) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3477895..3477902) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3477971..3478198) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" /label="yxeJ CDS" gene complement(3477971..3478198) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /label="yxeJ gene" CDS complement(3478185..3479171) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" /label="yxeI CDS" gene complement(3478185..3479171) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /label="yxeI gene" downshifts complement(3478189) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3478322..3478331 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3478345..3478364 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3478355..3478988 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3478355 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3479226..3479245) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3479237) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3479260..3479267) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3479326..3480138) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" /label="hadM CDS" gene complement(3479326..3480138) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /label="hadM gene" promotor_-10 complement(3480168..3480187) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3480178..3480735) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" /label="yxeG CDS" gene complement(3480178..3480735) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /label="yxeG gene" upshifts complement(3480191) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3480202..3480209) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3480716..3481150) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" /label="yxeF CDS" gene complement(3480716..3481150) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /label="yxeF gene" promotor_-35 3481175..3481184 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3481194 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3481197..3481216 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3481210) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3481211..3481622) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3481216..3481230) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3481239..3481243) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3481239..3481604 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" /label="cotNE CDS" gene 3481239..3481604 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /label="cotNE gene" downshifts 3481618 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3481622..3481626) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3481622) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3481624..3481710) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-10 complement(3481703..3481722) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3481710) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3481736..3481743) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3481783..3481789 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3481803..3481814 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3481810 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="upshifts" CDS 3481852..3482205 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" /label="yxeD CDS" gene 3481852..3482205 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /label="yxeD gene" downshifts 3482200 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(3482249..3482647) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" /label="yxeC CDS" gene complement(3482249..3482647) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /label="yxeC gene" downshifts complement(3482257) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3482662..3482681) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3482678) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3482696..3482699) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3482735..3482742 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3482751..3482769) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3482757..3482776 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3482766 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3482766) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3482785..3482790) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3482825..3483790 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" /label="frxB CDS" gene 3482825..3483790 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /label="frxB gene" upshifts 3483218 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3483225..3483243 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3483697 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" /label="downshifts" downshifts 3483768 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" /label="downshifts" S_feature 3483813..3484609 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3483831..3484178) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" /label="yxeA CDS" gene complement(3483831..3484178) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /label="yxeA gene" downshifts complement(3483844) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3484192..3486060) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" /label="tpeM CDS" gene complement(3484192..3486060) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /label="tpeM gene" CDS complement(3486035..3486808) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" /label="tpeL CDS" gene complement(3486035..3486808) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /label="tpeL gene" CDS complement(3486952..3487929) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" /label="tpeK CDS" gene complement(3486952..3487929) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /label="tpeK gene" CDS complement(3487926..3488615) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" /label="tpeJ CDS" gene complement(3487926..3488615) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /label="tpeJ gene" promotor_-10 complement(3488642..3488661) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3488660) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3488676..3488682) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3488723..3489595) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" /label="iolJ CDS" gene complement(3488723..3489595) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /label="iolJ gene" downshifts complement(3488727) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3489616..3490452) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" /label="iolI CDS" gene complement(3489616..3490452) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /label="iolI gene" S_feature complement(3490453..3490537) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3490538..3491407) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" /label="iolH CDS" gene complement(3490538..3491407) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /label="iolH gene" CDS complement(3491427..3492461) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" /label="iolG CDS" gene complement(3491427..3492461) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /label="iolG gene" CDS complement(3492484..3493800) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" /label="iolF CDS" gene complement(3492484..3493800) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /label="iolF gene" CDS complement(3493815..3494708) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" /label="iolE CDS" gene complement(3493815..3494708) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /label="iolE gene" CDS complement(3494725..3496638) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" /label="iolD CDS" gene complement(3494725..3496638) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /label="iolD gene" CDS complement(3496671..3497648) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" /label="iolC CDS" gene complement(3496671..3497648) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /label="iolC gene" CDS complement(3497672..3498487) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" /label="iolB CDS" gene complement(3497672..3498487) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /label="iolB gene" S_feature complement(3498488..3498561) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3498562..3500025) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" /label="iolA CDS" gene complement(3498562..3500025) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /label="iolA gene" S_feature complement(3500026..3500230) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3500029..3500036 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3500052..3500071 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3500059 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="upshifts" S_feature 3500066..3500372 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3500212..3500231) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3500230) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3500232..3500384) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3500246..3500253) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3500332..3500339 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3500354..3500373 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3500374 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="upshifts" promotor_-10 complement(3500385..3500404) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3500401) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="upshifts" promotor_-35 complement(3500420..3500427) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3500441..3501196 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" /label="iolR CDS" gene 3500441..3501196 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /label="iolR gene" promotor_-35 3501175..3501181 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3501196..3501215 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3501210 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3501250..3502182 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" /label="iolS CDS" gene 3501250..3502182 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /label="iolS gene" downshifts 3502184 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-35 3502261..3502268 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3502282..3502301 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3502288..3502443 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3502288 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3502444..3503094 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" /label="yxcE CDS" gene 3502444..3503094 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /label="yxcE gene" CDS 3503098..3503406 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" /label="yxcD CDS" gene 3503098..3503406 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /label="yxcD gene" downshifts 3503408 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 3503550..3503556 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3503572..3503590 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3503582 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3503644..3505029 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3503644..3505029 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3505015 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3505060..3505610 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3505071..3506951) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3505071..3506951) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3505077) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3506952..3507049) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3507040..3507059) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3507049) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3507074..3507081) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3507119..3507370) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3507119..3507370) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3507137) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3507392..3507411) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3507401) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3507434..3507440 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3507454..3507472 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3507455 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3507487..3508308 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3507487..3508308 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3508292 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3508337..3509479) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3508337..3509479) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3508347) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3509480..3509579) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3509567..3509586) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3509578) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3509600..3509607) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3509622..3510959 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3509622..3510959 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3510364..3510964) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3510998..3511477) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3510998..3511477) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3511009) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3511557..3512549) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3511557..3512549) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3511581) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3512539 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3512572..3512591) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3512590) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3512606..3512613) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3512612..3512619 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3512633..3513057 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3512633 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3512634..3512653 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3512639..3513051 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3512639..3513051 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3512659) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3512669..3512683) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3512691..3512695) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3513023 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3513058..3513792 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3513058..3513792 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3513792..3514061 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3513792..3514061 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3514065..3514547 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3514065..3514547 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3514568..3516811 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3514568..3516811 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3516808..3518007 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3516808..3518007 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3517763..3517781) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3517785) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3517796..3517802) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3517998 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3518071) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3518071..3519303) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3518071..3519303) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3519335..3519354) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3519347) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3519368..3519373) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3519404..3519829) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3519404..3519829) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3519857..3519876) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3519871) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3519889..3519895) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3520021..3520028 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3520038 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3520043..3520062 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3520086..3520541 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3520086..3520541 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3520479 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3520542..3521155 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3520571..3521779) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3520571..3521779) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3520598) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3521780..3521886) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3521887..3522900) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3521887..3522900) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3522901..3522974) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3522959..3522978) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3522974) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3522991..3522998) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3522994..3523569) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3522994..3523569) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3523018) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3523598..3523617) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3523612) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3523632..3523639) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3523640..3523646 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3523661..3523679 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3523668 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3523700..3524770 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3523700..3524770 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3524768 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3524827..3525258) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3524827..3525258) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3525288..3525295 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3525309..3525328 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3525318..3525484 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3525318 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3525370..3525389) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3525390) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3525404..3525411) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3525485..3525889 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3525485..3525889 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3525506..3526558) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3525859..3526551 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3525859..3526551 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3526591..3527622) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3526591..3527622) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3526603) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3527589..3527592 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3527605 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3527609..3527628 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3527659..3527677) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3527677) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3527692..3527698) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3527715..3528863) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3527715..3528863) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3528902..3528921) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3528913) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3528932..3528939) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3528985..3528992 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3529006..3529025 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3529013 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3529059..3529790 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3529059..3529790 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3529783..3531324 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3529783..3531324 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3531353..3532699 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3531353..3532699 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3532152..3532156 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3532172..3532191 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3532181 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3532722..3534128 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3532722..3534128 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3534117 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3534225..3534244 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3534227..3534518 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3534227 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3534491..3534498 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3534513..3534532 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3534520 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3534542..3534549 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3534564..3534583 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3534567) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3534570..3534584) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3534579 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3534592..3534596) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3534592..3535155 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3534592..3535155 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3535169..3536698 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3535169..3536698 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3536525) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3536691 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3536724..3536807) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3536767) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3536808..3538247) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3536808..3538247) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3538261..3538491) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3538261..3538491) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3538492..3538703) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3538700..3538719) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3538705) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3538734..3538741) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3538767..3538774 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3538785..3538804 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3538800 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3538835..3539545 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3538835..3539545 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3539573..3539731 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3539573..3539731 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3539808 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3539862..3540584) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3539862..3540584) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3539874) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3540485..3540488 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3540504..3540508 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3540519 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3540605..3541234) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3540605..3541234) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3541235..3541383) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3541384..3542142) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3541384..3542142) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3541832..3541851) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3541848) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3541864..3541871) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3542123..3543082) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3542123..3543082) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3543071 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3543118..3543121 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3543126 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3543140..3543289) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3543140..3543289) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3543147) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3543198..3543215 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3543203 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3543284 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3543310..3543329) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3543331) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3543344..3543351) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3543624..3543631 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3543646..3543665 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3543650 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3543761..3545686 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3543761..3545686 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3545687..3547051 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3545899..3546219) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3546220..3547980) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3546220..3547980) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3546263) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3547048..3547049 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3547053 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3547980..3548378) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3547980..3548378) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3548371..3549816) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3548371..3549816) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3549066..3549073 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3549085..3549104 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3549095..3550144 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3549095 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3549817..3550077) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3550078..3550557) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3550078..3550557) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3550558..3550637) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3550638..3550808) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3550638..3550808) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3550849..3550868) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3550865) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3550882..3550887) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3550931..3550938 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3550951..3550970 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3550968 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3550993..3551406 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3550993..3551406 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3551386 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3551440..3552666) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3551440..3552666) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3551455) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3552689..3552707) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3552694) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3552719..3552727) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3552729..3552899) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3552729..3552899) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3552918..3552936) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3552936) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3552950..3552956) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3553004..3553252) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3553004..3553252) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3553268..3554431) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3553268..3554431) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3553302..3553320) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3553310) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3553332..3553340) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3554442..3555179) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3554442..3555179) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3555221..3555239) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3555227) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3555253..3555261) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3555321..3555791) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3555321..3555791) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3555334) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3555792..3555862) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3555823..3555829 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3555843..3555862 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3555844..3555863) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3555844 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3555862) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3555864..3556139) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3555878..3555885) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3555902..3556999 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3555902..3556999 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3556130..3556148) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3556139) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3556163..3556168) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3556723..3556731 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3556743..3556761 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3556756 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3557000..3557116 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3557000..3557116 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3557105 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3557353..3558243) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3557353..3558243) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3557359) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3557421) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3558317..3559720) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3558317..3559720) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3559721..3559942) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3559943..3561148) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3559943..3561148) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3561205..3561223) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3561208) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3561318..3561323 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3561338..3561357 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3561353 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3561389..3562774 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3561389..3562774 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3562756..3562944) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3562756..3562944) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3563061..3563189) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3563061..3563189) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3563113 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3563209..3564411) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3563209..3564411) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3563233) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3564443..3564454) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3564443) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3564469..3564475) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3564493..3565287) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3564493..3565287) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3565309..3566151) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3565309..3566151) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3566138..3567505) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3566138..3567505) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3566732,3566734) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3567495..3569330) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3567495..3569330) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3569338..3570045) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3569338..3570045) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3570046..3570142) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3570130..3570149) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3570142) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3570144..3570336) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3570165..3570168) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3570336) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3570346..3570365) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3570428) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3570429..3570501) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3570429..3570501) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3570537..3570613) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3570537..3570613) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3570614..3570694) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3570695..3570766) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3570695..3570766) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3570776..3570851) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3570776..3570851) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3570823..3570839 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3570836 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3570852..3570948) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3570932..3570951) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3570948) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3570965..3570972) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3570982..3571083) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3571022) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3571076..3572368) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3571076..3572368) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3571087) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3572408..3572427) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3572428) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3572442..3572449) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3572574..3572993) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3572574..3572993) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3572991..3573002) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3573002) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3573017..3573023) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3573114..3574478) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3573114..3574478) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3573134) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3573178) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3574509..3574528) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3574523) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3574543..3574545) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3574590..3574596 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3574611..3574629 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3574613 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3574648..3574848 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3574648..3574848 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3574818 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3574863..3575184 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3574896..3575099) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3574896..3575099) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3575100..3575400) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3575165..3575168 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3575183..3575202 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3575186 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3575220..3575360 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3575220..3575360 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3575361..3575432 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3575408) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3575411..3575425) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3575433..3575437) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3575433..3576641 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3575433..3576641 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3576622 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3576746..3578803 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3576746..3578803 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3578668 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3578840..3579289) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3578840..3579289) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3578854) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3579286..3581265) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3579286..3581265) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3579767..3579786) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3579770) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3580183..3580190 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3580204..3580222 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3580208..3580874 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3580208 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3581302..3582231) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3581302..3582231) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3582232..3582368) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3582350..3582369) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3582368) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3582384..3582389) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3582458..3582607) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3582458..3582607) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3582484) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3582646..3582665) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3582663) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3582679..3582685) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3582686..3582695 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3582708..3582727 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3582714 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3582726) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3582728..3583241) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3582730..3582744) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3582753..3582757) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3582753..3583235 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3582753..3583235 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3583222 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3583265..3583642) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3583265..3583642) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3583267..3583796 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3583286) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3583697..3583716) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3583709) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3583730..3583737) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3583778..3583782 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3583796..3583815 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3583798 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3583823..3583837) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3583826) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3583847..3584776 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3583847..3584776 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3584762 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3584805) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" /label="downshifts" CDS complement(3584809..3585255) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" /label="yybP CDS" gene complement(3584809..3585255) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /label="yybP gene" S_feature complement(3585256..3585586) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3585445..3585562) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /label="mswM RNA" gene complement(3585445..3585562) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /label="mswM gene" promotor_-10 complement(3585577..3585596) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3585585) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3585610..3585617) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3585623..3585629 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3585642 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3585644..3585662 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3585658..3585664 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3585679..3585690 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3585686 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" CDS 3585688..3586995 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" /label="yybO CDS" gene 3585688..3586995 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /label="yybO gene" downshifts complement(3586796) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 3586984 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3587039..3587278) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" /label="yyzI CDS" gene complement(3587039..3587278) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo /label="yyzI gene" downshifts complement(3587060) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3587064..3587164) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3587104) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3587268..3587432) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" /label="yyzJ CDS" gene complement(3587268..3587432) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo /label="yyzJ gene" CDS complement(3587444..3587629) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" /label="hypothetical protein CDS" gene complement(3587444..3587629) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /label="gene" downshifts 3587710 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" /label="downshifts" CDS complement(3587902..3588048) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" /label="yyzK CDS" gene complement(3587902..3588048) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo /label="yyzK gene" CDS complement(3588030..3588179) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" /label="yyzL CDS" gene complement(3588030..3588179) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo /label="yyzL gene" misc_feature complement(3588495..3588511) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3588512) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3588531..3588538 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3588553..3588756 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3588553..3588572 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3588553 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3588574..3588588) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3588578) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="upshifts" CDS 3588757..3589194 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" /label="yybN CDS" gene 3588757..3589194 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /label="yybN gene" S_feature 3589195..3589271 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3589228 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" /label="downshifts" CDS 3589308..3590063 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" /label="yybM CDS" gene 3589308..3590063 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /label="yybM gene" S_feature complement(3589903..3592492) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3590053..3590763 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" /label="yybL CDS" gene 3590053..3590763 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /label="yybL gene" downshifts 3590262 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" /label="downshifts" CDS 3590760..3591515 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" /label="yybK CDS" gene 3590760..3591515 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /label="yybK gene" CDS 3591512..3592167 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKLKRLQF*IISLIHLKKEQFMDYLGVMVLERPCYF VHYPG**SLLKGV*LLKVNNYIKISLFLKV*D*L*KICSYFLSMMLLLTLKFCQKLKR SHQIMIY*ILLVELVWKILIV*RLVNSR*E*NND*ILHRLFLKNLIYCYLMNQQMRLM KKELHLFMTFFYKRKKGELPLLLLVITRKILYLYVTLH*K*IMDV*KLQKK*YIRKIV " /label="yybJ CDS" gene 3591512..3592167 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /label="yybJ gene" S_feature 3592168..3592482 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3592439 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 3592483 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(3592537) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" /label="downshifts" CDS complement(3592542..3593330) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" /label="ictI CDS" gene complement(3592542..3593330) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /label="ictI gene" promotor_-10 complement(3593354..3593372) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3593373) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3593388..3593393) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3593398..3593787) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" /label="yybH CDS" gene complement(3593398..3593787) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /label="yybH gene" promotor_-35 3593856..3593859 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3593874..3593893 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3593887 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="upshifts" CDS 3593933..3594772 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" /label="yybG CDS" gene 3593933..3594772 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /label="yybG gene" downshifts 3594749 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3594805..3596019) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" /label="yybF CDS" gene complement(3594805..3596019) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /label="yybF gene" downshifts complement(3594823) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(3596020..3596123) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3596116..3596135) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3596124..3596131 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3596126) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3596145..3596164 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3596149..3596156) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3596157 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="upshifts" CDS 3596206..3597084 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" /label="yybE CDS" gene 3596206..3597084 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /label="yybE gene" CDS 3597098..3597541 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" /label="yybD CDS" gene 3597098..3597541 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /label="yybD gene" CDS 3597624..3598103 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " /label="yybC CDS" gene 3597624..3598103 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /label="yybC gene" downshifts 3598093 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(3598278..3598940) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" /label="yybB CDS" gene complement(3598278..3598940) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /label="yybB gene" CDS complement(3599087..3599539) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" /label="yybA CDS" gene complement(3599087..3599539) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /label="yybA gene" promotor_-35 3599563..3599570 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3599585..3599604 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3599587 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="upshifts" S_feature 3599589..3599658 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3599592..3599611) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3599594) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3599624..3599631) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3599659..3600105 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" /label="yyaT CDS" gene 3599659..3600105 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /label="yyaT gene" CDS 3600102..3600707 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" /label="yyaS CDS" gene 3600102..3600707 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /label="yyaS gene" CDS complement(3600802..3601323) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" /label="yyaR CDS" gene complement(3600802..3601323) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /label="yyaR gene" S_feature complement(3601324..3602151) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3601372..3601379 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3601393 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3601394..3601413 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3601459..3601733 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3601459 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3601462..3601467 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3601480..3601499 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3601734..3602090 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" /label="yyaQ CDS" gene 3601734..3602090 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /label="yyaQ gene" S_feature 3602091..3602249 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3602133..3602152) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3602151) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3602167..3602174) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3602250..3602816 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" /label="yyaP CDS" gene 3602250..3602816 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /label="yyaP gene" CDS complement(3603323..3604699) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" /label="tetB CDS" gene complement(3603323..3604699) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /label="tetB gene" CDS complement(3604733..3604795) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" /label="tetL CDS" gene complement(3604733..3604795) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /label="tetL gene" promotor_-10 complement(3604816..3604835) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3604835) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3604848..3604855) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3604983..3604989 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3605005..3605024 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3605011 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="upshifts" CDS 3605048..3605287 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" /label="yyaO CDS" gene 3605048..3605287 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /label="yyaO gene" downshifts 3605296 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 3605380..3605387 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3605403..3605422 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3605419 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="upshifts" CDS 3605438..3605854 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" /label="yyaN CDS" gene 3605438..3605854 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /label="yyaN gene" CDS 3605851..3606768 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" /label="yyaM CDS" gene 3605851..3606768 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /label="yyaM gene" misc_feature 3606795..3606814 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3606805 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3606809..3606828) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3606815) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3606840..3608909 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" /label="yyaL CDS" gene 3606840..3608909 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /label="yyaL gene" promotor_-35 complement(3606842..3606849) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3608873 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3608906..3609805) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" /label="yyaK CDS" gene complement(3608906..3609805) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /label="yyaK gene" downshifts complement(3608949) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3609834..3609853) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3609850) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3609852..3611083) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3609868..3609875) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3609946..3609953 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3609967..3609986 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3609973 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3610031..3611386 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" /label="yyaJ CDS" gene 3610031..3611386 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /label="yyaJ gene" promotor_-10 complement(3611069..3611088) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3611093) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3611102..3611111) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3611420..3611974) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3611420..3611974) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3611992..3612372) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3611992..3612372) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3612428..3613363) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3612428..3613363) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3613353..3613362 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3613376..3613395 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3613383 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3613407..3613426) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3613421) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3613422..3614180) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3613422..3614180) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3613439..3613446) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3613713..3614216 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3614175 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3614245..3614484) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3614245..3614484) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3614251) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3614319) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3614528..3615046) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3614528..3615046) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3615087..3615374) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3615087..3615374) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3615375..3615441) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3615440..3615459) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3615441) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3615473..3615478) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3615485..3616585) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3615485..3616585) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3616633..3616652) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3616648) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3616667..3616674) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3616712..3618715) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3616712..3618715) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3618766..3618972) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3618766..3618972) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3618934..3618953) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3618959) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3618968..3618974) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3618998..3619017) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3619009) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3619034..3619038) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3619066..3620082) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3619066..3620082) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3620115..3620133) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3620127) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3620149..3620154) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3620258) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3620442..3620447 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3620460..3620541 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3620460 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3620463..3620481 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3620542..3621159 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3620542..3621159 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3621130..3621138 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3621149 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3621152..3621170 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3621171 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3621198..3622046) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3621198..3622046) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3621218) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3622039..3622800) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3622039..3622800) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3622834..3622853) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3622852) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3622944) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3622947..3622955) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3622969..3622977) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3622981..3622989 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3622997 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3623001..3623019 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3623048..3623488 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3623048..3623488 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3623437 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3623539..3624390) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3623539..3624390) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3623558) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3624391..3624511) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3624512..3625231) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3624512..3625231) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3625245..3627131) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3625245..3627131) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3627152..3628531) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3627152..3628531) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3628532..3628662) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3628654..3628673) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3628662) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3628689..3628693) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3628717..3628736) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3628727) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3628750..3628757) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3628817..3628823 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3628828..3631113 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3628828 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3628838..3628857 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3628842..3629468) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3628842..3629468) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3628859) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3629465..3630250) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3629465..3630250) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3630295..3630314) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3630307) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3630309..3630394) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3630326..3630332) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3630395..3630745) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3630395..3630745) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3630746..3630896) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3630897..3631031) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3630897..3631031) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3631055..3631155 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3631067..3631086) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3631077) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3631079..3631147) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3631102..3631109) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3631115..>3631248 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3631115 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3631133..3631152) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3631147) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3631168..3631172) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3631249..3631396 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3631272..3631545) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3631398..3631657 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggcctttgt gagtaacatg atagtaatca 399541 tagagaagga ggctcgcaat tggctgaatt catattaaat gcagcggatt tcggtgttcc 399601 tagagatggt aaaacggatt cgacagaacg gattaatcag tgcctcagta cagctgtttc 399661 gaaaggctat catactgtct ggtttccaaa gggaacatat ttaatagacg caacgcttgg 399721 cggagatctt aatcagaggt ttcgaaacgc ggggatcatt gttcccggca accttgagat 399781 tatgatggac cccgaatgta tcatgaaagt gataccgaat agttcgtggg gttattccgc 399841 attttatgta ggcaagcaag agaatataac tatttccgga ggacaaatta tcggcgaacg 399901 ggatgagcat acgtatgcct cggcggggat aaggtcaacc catgaatggg gctttggcat 399961 atgtattgaa ggatgctcga atgttgtcat tgatgatgtg aaaatttccg attttaccgg 400021 cgatgggatc atagtcagcc caaggggatt aaagaccaat caagattatc gaacgtcaga 400081 gcaaattatc atccgccgct gtgaggttcg gcggtcgagg agaaataaca tttccattac 400141 cggatgtgac atggtcacgg tggaggaatg cttgattgaa gatgccggaa cggggaatgg 400201 aacagcgccg aaattcggaa ttgacattga aggatatggc gaaggtgacg ttgattatga 400261 ggaaccgatt aatgtatcaa ttcgcaataa ccactttgtt ggaaacgttt caagttctgt 400321 gaccaatttt aacgggtatg gcattttaat agaaggaaat cactcagaca atacaatcag 400381 ctacggatat gggacgcaaa cagtgatcaa gggcaatatt ctgagacgcc ctgaagacgc 400441 ggcggctgcg ccaagagtcg ggataaccgg actcggtgta tcacaaggaa aagagaccag 400501 tgatgcagtg atcgctggca acctcattac cggattttca actggaattg atgtcagggg 400561 aaagagcgtt cttgtgacga acaacaaaat cagcaacttt gaaaacacag ggatattggt 400621 ttatcagtcc tccgacgtaa aggtagacgg aaaccaaatt caaaacggac tgtctgaaac 400681 aaggcgcagc atcggtcttc gcgcagtgct gtcagatgac atcgcatttc tgaataactg 400741 tctcattcaa gtcgttgacg gtgtgaacgt ttccggcgga aatatgatca ttaaagataa 400801 tctcctgaga aaattcagcc ggggcatttg gattgctcaa gggaacgcgg tgattgaagg 400861 gaatacactg aatcctgacg cgtttgaagc agtgccggaa tcatattctg tttccgtcac 400921 aaacaatgcc ggcgccatca tcaaaaacaa tacatttaaa gagttcaaaa attaccccat 400981 ttattgctcc acaagtgcaa aaacctcaat tatcggcaac cacttagagc gatccccgct 401041 tttggtcacc atctatatca gcgcaggtgt gcatgagatt tttgataata ccatttcagt 401101 caacagaaca gccgggaatc cgattgtgat ttatctcaat ggctctgcag gctctatcat 401161 ctctggaaac accatcaata acctctccgc gggcactgcg acagctattc aaacaaacac 401221 gtcaaccaat tccaaaatca tcggcaaccg catttttaaa gggaccatca acaaacacag 401281 cagtgataca atagacggca atatgattgt ctgaaaaaag cgcccccctt taggggttct 401341 tttttttcga tttatagatc acgtacattt ctctcacaag tactaacaca aaaaataaaa 401401 gcacgaccca ttccgcaaat gttgtcatct taaagctgga catattgtta taaacggctt 401461 ttgttaaact gaacccttga agcatgtcca tcaacacaga aatagctaat aaacaaatta 401521 atatgaatcc ggtcacgccc aatatcttca tgcttcatca tcctccgctt ttagtgtcta 401581 tctttggcgg agaagttata ccgcatctaa ccctaatgca taatctcaat tttaaaagga 401641 agaatatgag aaaacgacaa ggaaaggtat ttgtgtatgc ctttattttc taagcgaaag 401701 aacaataccg attcaaaaga caagcagaat acagacgaaa ggaatcagga acagcagcaa 401761 gaaaaagaaa ggccggttct catttctcca agtttagcaa agaatatagc ggaaacgaaa 401821 aaggaagtcg gaagcagctc tgacgtcatc attcgcgaga ttaaaatcgg ggagcaggat 401881 catgtccacc tagctgttat ctatatttct gggctggtcg ataataacac gatccatgag 401941 tcgttaattg acccattggt acaggatgag tctatccaga atactcatgc gatccagcaa 402001 attcttgaaa aaacgctccc gctgggcggg gtgaaagcgg aaaagagctg ggacaagctt 402061 ttttccgagt taatgcttgg caatgcgctc atttttgctg atggccatga tgaagctttg 402121 atttgcagca ctcaaggggg agagcagcgc tccatccaag agccgagcac ccaggtgtca 402181 ttccgcggcc cgcgccaagg gtttacagag tctctgcaaa ccaatatttc catgatccgg 402241 cgatacatta aaaatccgaa tttatgggtt gaaaaaatga aaaaaggttc tgttacgaat 402301 acggatatcg ctctcatgta cattcaagga atatgtgatg aaaaggtgct gaaggaagtg 402361 aaacagcgcc tggaaaaaat agatattgac agtattttgg aatctggata tattgagcag 402421 ctgattgaag atgaaacctt tacgacgttt ccgactatgt atcatacaga acgccctgat 402481 gttgtagcgg gtaatctgtt agaaggaaga ttcgcgatta ttgtggacgg aacaccgttt 402541 gtgcttattg ccccagcctt atttgtccag ttttttcagt ctgttgagga ttattattcg 402601 cgttttgaca ttgcgacaag cataagaatt cttcgtgttt tagtcttttt catttcgctt 402661 gtggcaccag ctgtatacgt ggcagccacg acgtttcatc aagaaatgat accgactcag 402721 ctgttagtgg tcattgcggc ccagcgggaa attgtcccgt ttccggctgt tgtggaggcg 402781 ctgacgatgg aggttgcttt tgagattctg agggaagcgg gagtcaggct gccccgggtt 402841 gtcggctcgg cagtgtcaat cgtaggcgcg ctcgtaatcg gccaggctgc cgtacaggct 402901 ggtatcgtct ctccggcaat ggtgattatc gtggcactca ccgcgattgc gagcttcgca 402961 acaccggcgt ttgcaatggc gatttcagcc cggcttattc ggtttatctt tattattgcc 403021 tcagctgtta tgggttttta cgggctgatt ttagggatca ttatgatgtt tgtccactta 403081 tgcagtcttc gttcattcgg cgttccatat atgtcgccgc ttgcaccttt ttcttcacaa 403141 ggcgtaaagg acgcgctttt ccgggttccg tggtgggccg atgaaaaaag gccggaatcg 403201 gtcagcaagg aagataaggt gcggcagggg aaagatcaac gcccagagcc ggccgcttca 403261 cgaggaatgg tgaacaaaga tttggaagaa ggggatcaga atggtacgta aatgtctatt 403321 agccgttctc atgcttttga gcgtcattgt gctgcccggc tgctgggata agcgggagct 403381 gacggatctt gcgattatct cggcgattgg catcgatcgg acaaacgaca gcaactacgt 403441 gctgcatctt caaattatca atccaggaaa tgttgccggc ggccttcagg gaggcggtgc 403501 tggagacagg ccgcctgtat ctgtctattc gattgaaggt aacaatataa cggaagcact 403561 cagaaaagcc tccatgaagg tatcacggcg gctttatttt gcccatacca atctagtcgt 403621 gatcaatgaa aagctggcaa aagaagaagg tttggatttt gtattagata atcttgaccg 403681 ggacacagaa ttcaggacaa cagcaacatt cgtcgttgcc cataaaacaa aagcagaaaa 403741 tattgtgaaa atcttgacgc cgattgataa aattccgtca aataaagtca ataaaacact 403801 cgatttcacg gaggcacaat acgggcgggt ggtcaaaatc aatattcagg acgttttgaa 403861 aacacttgcc gccaacacta tggcaccggt catccccgga tatatgatga ttggtgacga 403921 taaaaaagga gtcagcatgg aaaacacgca ggcgactgac ccgaaagcca ttcttcaggc 403981 agatggtttg gcggtttttg ataaggcagg atatttaaag tattggctgg aagatgatga 404041 aagcgtgggg gcagtctggc ttatgaataa gatccagcat acgtttatta atgctgactg 404101 gggcaagacg aaggatgcgg tcagcttgca ggttacccat caagatacaa agctggtacc 404161 gaaaatgcgg aacggacgcc cgtacatcca tgtgaaagtg tcggttgaag gtattataga 404221 tgctgtcaaa taccctttcc aattgtctga tcccaaggtg ctggccgcta ttgaaaaagc 404281 gctcaacaaa gagcttgaaa aggaaatcag ccatactgtg aaaaagatta agaagaataa 404341 aatagatttt atcggttttg gtgacacgat atatagaaag tatccggagc agtgggagaa 404401 aatgaaggac acttgggaca aagaatattt gccggaactg cccatcgatg tgaaggccga 404461 gacgtatatc agaaggacgg gattgcgaaa caatccgatc aaacaccagt ttaaagatga 404521 ttaggtctga agaaagggga agtgacagat ggaaaaagcc agaataagca taaggcagtt 404581 gtttgtcatg attatcattt ttgaactggg cagctcctta ttgattacac cgggatcaat 404641 ggcgggcagg gatgcttgga tagcagtttt attaggctgt gcgatcggac tgtttctttt 404701 ctatttgtat caaggcattt atcaatgtta tccgaattct tctccgaaag aatatatgga 404761 tgatatgctg ggaaccaagc tgagctggct gttttcattt ctctatatct tgtactttgc 404821 ctatattgcc gcaagggtgc tgcgtgactt tggagaaatg ctgctgacgt ttgcttatca 404881 tgatacacct atcattattg taaatgcttt attaatggta gtaagcatat atgccgtaag 404941 aaaaggaatt gaagtactcg cacgcgcggc cgaacttctt ttcggggcca tgtatttact 405001 gggcgcgatc ggccttgtgc tgattattgt ctcagggact atagacccgc acaatttaaa 405061 gccggttttg gcaaacggca tttctcctgt ccttcactct gttttcacac agaccatgta 405121 cgttccattt ggtgaagttg ttttatttgt gatgattttc cctaacctga atgacagaaa 405181 agatgtgaaa aaaatgggga tgatcgccat ggctattagc ggattgattg tggcgctcac 405241 cgtggcgatt aatattagcg tgcttgatgt tgatcttaca ctcagatccc agtttccgct 405301 tttaagcacg atccagacaa tcaaggtcga agaattttta gaccggctcg atgtcttttt 405361 tatgctggcg ctgatcatcg gcggcttctt taaggtcagc ctctacttat atgccactgt 405421 ggttgggaca tctacgctct ttaaggaaaa gaacccctct caattggctt atccgatggg 405481 attgggcatc ttaatccttt ctataacgat cgcgactaac ttttcggagc acttgaatga 405541 aggcctgaac gtggtgccgc tgtatattca tttgcctttt caattattgt ttccgctctt 405601 tctgtttatt gtggccgttt ggaaaaagaa acgaagagag aagtcaaaag gggaggaagc 405661 aaaaaaatga taaaaagagc ggggggatgc ggccgccgct ctttttatgt tcacttctat 405721 ataaaagggg gatatagggt gcgcccctgt ctgcactggc agaggcgcgt tttgttatac 405781 gactgcgacg ttttccttca cagtaaaact tcctcttgaa agtctgatat tgatgtctga 405841 cacttttgca atttgttcat cgtgcgtcac cataatgacg catttatctt ccttgtgcgc 405901 cagatcctga aagagccgta cgatctcttt tgatgtgtcc tcatcaaggt ttccggtcgg 405961 ttcatcggct acgataagat ccgtgtcaca gcagaaagcc cttgtaattg atacccgctg 406021 ctgctgtccg ccgctcagtg tgagcacttt ttgccgggct tgtttttcgt tgatgccaac 406081 cttctgcagc atgtcaagcg catatgattc tttgttcttt tctttagaac ctgtgatttc 406141 catagcggtt gtgacgttct gcaaagccgt catatacggg agcaggttgt acgcctgaaa 406201 gacgattgat acatattgat ttctgaaatt ggttaagccg attttagaaa ccgcttttcc 406261 gtcgtaaagg atgtttcctt cttttggtgc gtcaagtccg cctgccagag acaggaaagt 406321 ggttttcccc gtccctgatg ttccgacgat tgtgtagaat tttccttttt gaaagctgat 406381 gttaatatcc tgaaacaatg gctggctttt gtttttatac cagtagccga cttgttgaaa 406441 ttgtaataag ctcataggtt ccgcctcttt ctattcctgt tttgtcaata tcgttttcgg 406501 atgaagccgc agtactgaaa ttgacggcag caatgttgca atgattgcga ttaggatgcc 406561 gatcccgcca agtataagca tgtcgttcat agaaaccgcg acgttcagtg aatcgataac 406621 gtccacgttg gatgaactgt ggccgaacat tttgccgccc atgccgccac cgccgccggg 406681 catttgtccg cttgcggttt gcgttgaatc ggttgatgaa ctgatttgct gggataaaag 406741 ctgatttcca agctgattcg cgacgagatt tcccgtcaca gatgcaaggc cgatagcgat 406801 aacggccaca atcagaatct cagtcaagaa ctgtccaatc aatttccatc gtttttcacc 406861 gatggccatt aacacgccca tttcgtattt gcgctccctg attgacatca tgacaatcag 406921 gccaagaatg acggcgcctg ccactgatac aagatacacc acgtttttag agaaagaagc 406981 cacattttca atcggtccga ccatttgctg gtaaagctga tcgtttgtat tcagtgtgta 407041 cgtatcaaag tcaattgatg ttttcttcgc tgcttttacg aaagtatcca tatttttcgc 407101 gtcgtccata tagtaaacag ctgagtcaat cgtattttta tagtcgtcgc ctttcaatgc 407161 cgctgttgct gtgtaaggcg tataaagctt gttataagga tttaagaaag agaaattttg 407221 ggcttggtca tcacctgaag atgttgtttt ataaataccg acgatcttca gttttactgt 407281 tgtatcctca tccgttgctg attcaattgt gatcgaatcg ccaacgctta aatcattttc 407341 ttccgctaat gtttcgttga tcactgttac ttttttgccg acatctgatt ttgtaatcgc 407401 gcgtccgtct gtgatttttg aatctccgtc agagaaatca tcgactaacg ctgtgctgat 407461 gacaccttca atagaaagat cagcttgaac catttgcggt ccgccttgtc ctccgccttg 407521 actgttttta gcgtttgagc ttgaactgct ggagctggaa tcacttgaac tagagctttc 407581 aatcgcatca aagtttcccg cgttggctga agctgatgtg gtgtaattgt agctcttcac 407641 atgatcaagc gctgcaagct tattcgcatc agacactttg atcggtgtgg attcgaagct 407701 gcgcttttca ccgctgtcct gctgtttttc catttgcttt tggcggtcaa cctgaagtgt 407761 cacgcttcca ccgagttcct gtctggccag ttcgcttgac ttttgtgctg ccgactggat 407821 ggcgaggcct gatagaacaa agacacatat gactgtaaac acaaataatt gcaataacgt 407881 ttttcccttt ttagccttca tattccaaaa ggcccgtttg ataaagttca tttatgttcc 407941 tccgtatagg tatttttatt gataagaccg cctctggggc gcgtcccctt gctgataaat 408001 taatagtagt ccaaaggtat gaaaaaaata tgaacaatct atttctagtt gatgaaataa 408061 aaactaacaa ttgtgaaacg caaaaccttc tgtttaaaat ggtgctatta tataaaaaag 408121 catcaaaaca accggaggat ataatgaaaa tattaatgat agaagataat gttagtgtat 408181 gtacgatgac ggagatgttc ttttttaaag aaggttttga agccgaattc gttcatgacg 408241 ggttagaagg gtaccagcgt tttacggaag aaaattggga tctaatcatt ttggatatca 408301 tgcttccatc tatggacggc gtgaccatct gcagaaaaat aagagagaca agcacggtgc 408361 cgattatcat gctgactgcc aaagacactg aatcagatca ggtcatcggt tttgagatgg 408421 gggcggacga ttatgtcaca aagccgttca gcccgctgac attggttgcc cgcatcaaag 408481 ccgtcatcag aagatataag gcgacaggca aagcggttat tgatgaagat atgattgaaa 408541 cggaatgctt taccattaat aagaagacga gagaagtatt attaaacgga gagcctgtag 408601 aaaatctcac gccgaaggaa ttcgatctgc tttattacct tgtccaaaat ccgcggcagg 408661 tgttctccag agaacagctg cttgagcagg tatggggcta tcaattttat ggagatgagc 408721 gaacggttga cgttcatatc aaacggctgc ggaaaaagct tgccagcgag gacaagcctt 408781 tcctgtatac tgtgtgggga gtagggtata aatttgatga agattaaata tttatatcag 408841 ctgctgctaa gccatatcag cattttgatt ttagcgtttg tcattatcat ttctctgttt 408901 tcccactttg tgaaggaatt tgcctatcag aacaaagtag aggaattgac gtcatatgcg 408961 gtgcagattg caaatgaatt ccaatccggc caggtggaca tgcgcaggct ctatccttat 409021 caggacattt taagcacaag aaagacgcaa tttatcatct ttaatgaaga gcagcagcct 409081 tattttcttc ctgaaggctt tcatcaccca ccaagggaac agctgaagaa atcagaatgg 409141 aataagctga aaaaagggca gactgtcacg atcagggcag atggccgttt tgatgatgaa 409201 gtgtcccttg tggcgcagcc tatatttgtt cagaacgaat ttaaaggcgc cgttctgctg 409261 atttctccga tcagcggtgt tgaacagatg gtcaatcagg tcaacctcta tatgttttac 409321 gctgtgatca gcacgcttgt gattacgatt cttgtgagct ggcttctgtc caaattccat 409381 gtcaagcgga ttcaaaagct gagagaagcg acagataaag tggcttccgg cgattatgac 409441 atccatttgg aaaacagcta cggggacgaa atcggcgtac tggcgtctga ctttaatatc 409501 atggcgaaaa aactaaagca gtcaagggat gaaatcgagc gccttgagaa gcggagaagg 409561 cagtttatcg ctgacgtgtc acatgaatta aaaacaccgc tgacgacgat caacggtttg 409621 gttgaagggt tgaacagcca tacgattcct gaggataaaa aggataaatg cttctcgctg 409681 atcagtgagg aaacgaagcg catgctgcgg ctcgtaaaag aaaatctgga ttatgaaaaa 409741 atcagatccc agcaaattac cttgaacaag ctagacgttc ctctgatcga ggtgtttgaa 409801 atcgtgaaag agcacttgca gcagcaggcg gaagaaaaac aaaacaagct gatgatccaa 409861 gtagaggatc acgtcatcgt acatgccgat tatgaccggt tcattcaaat tctcgtcaac 409921 attacgaaaa acagcatcca atttacgcaa aacggtgaca tttggctgcg cggaatggaa 409981 ggttataaag agacgattat tgaaattgaa gacacgggta tcggcattcc aaaagaggat 410041 attgagcata tttgggagcg attctataaa gcagatattt caagaacgaa cacagcatac 410101 ggtgaatacg gactcggtct ctcgatcgtc aggcagctcg ttgaaatgca ccagggcaca 410161 gtagaaatca agagtgaaga agggaaaggc acaaagttca tcatccgcct tcctttaacg 410221 gcaaaacagc aatagcatac agggcggcgc atcaactgat gcatccgcct tttttgcaca 410281 ccgcttcggt ttattgcgtg ctcccgaaaa caaagattgc gtgtttttcg ggttgggacg 410341 gcctataaac atgataaaat atgacataaa cagtttttga tgggagaggg tgaaggaatg 410401 aagagtgggg taattccttc ttcagcggtc ggtcaaaaaa ttaacgagtg gtacagatat 410461 atccggacat tcagcgtgcc ggatgccgaa gtgttaaaag ctgaaatcca gcaggaactg 410521 aaacacatgc agcatgattc caacttgctg ctttattatt cactaatgga attccggcac 410581 cagcttatgc tggattatct tgagccgtta gagaaattaa atatcgaaga ccagccaagc 410641 ctgtctgaat tatcaagaaa cattgacagc aaccaggcag atctcaaagg gctgctcgac 410701 tattacgtga atttttttcg cgggatgtat gaatttgata agcgggaatt tatttctgcc 410761 attacatact ataaacaggc ggagaaaaag ctctcctttg tcgcagacca tattgaacgg 410821 gctgaattct attttaaaat cgcggaagct tattattata tgaagcaaac gtatttttca 410881 ttgattaata taaaaaacgc ctatgaaatt tacgtggagc aggaaaccta taatgtgaga 410941 atcattcagt gccatttcgt cttcggggtc aacctgatgg atgaaagaaa tttcgaacaa 411001 gccgcacgcc atttcaaatt ggcgctcaac atggcccaag cagaacaaaa agcccagctg 411061 gttggaagag catactacaa tctcgggtta tgctattaca atcaagacct tctagaccct 411121 gccattgatt actttgaaaa agcggtctcc acatttgaaa gcagcaggat cgtcaattct 411181 ctcccgcaag cctatttttt aatcaccctg atttattata aacagggaaa acatgataaa 411241 gcttcggaat atcacaagcg gggctatgaa tatgctaaag aaacagacga tgcagactat 411301 gccgtaaaat tcgagttttt gcaatcccta tatctggatc agcccaatga agaaggaatc 411361 gaacgatgtt tccagtactt aaaaaataaa aatatgtacg ctgatataga ggatttagcc 411421 ctagaagtag caaaatatta ctatgaacag aaatggttta aactgtctgc ttcctacttt 411481 ctacaagttg aagaggcaag aaaacaaata caaaggagtg aaggtttgta tgaaattgaa 411541 atctaagttg tttgttattt gtttggccgc agccgcgatt tttacagcgg ctggcgtttc 411601 tgctaatgcg gaagcactcg actttcatgt gacagaaaga ggaatgacgt aagaacaagc 411661 cccttctcat tagcgagaag gggtttttct tttcaaaaaa acaccgcaag acatagtctt 411721 gcggtgccgc cttcatggag attacgttta tttagtagcc tcctacaaat gcagttccca 411781 caatgatcaa gaggataaat aacacaacaa tcaaagcgaa agaagttccg taacctgaca 411841 ttttgtgcac ctccttgcga gattgcttca gcaaatgctg caaaactgtg gcggacaggg 411901 tcccgcagag acggtcagca gcttagaagc cgccaacaaa cgcagtccct acgataatta 411961 atagaataaa caatacaacg attaaagcga aagaactgat gccgccgtaa ccgccgccgt 412021 tagagtatcc tgacataagg tttcacctcc ctatgaagga tactataaga tatgctgaac 412081 cgatccattt ggcagggata atagtggaca agagaaaaaa tgaagaattc ggctatatga 412141 aggtgatata aaaaaatagc gggcgctgcc gcccgctatt tatgtacgat taagagatca 412201 gcacgcccgc gaaaaattcc tggtataacg cttgaacggc ttttctttct tcggcttctt 412261 ttacgccaaa catcatgctc acttcagaag acccctgatt gatcatttcg atattcacct 412321 gtgcctctga taatgctttg gcggctcttg ccgttgtacc gacattgtgg cgcatcgctt 412381 cccctacaac cataatcagg gcgagatgat gctcgacgat gacttcatcg gcatgcaaat 412441 cctcttcgat ccgtttgatg acgctgcgtt cagtggcggc atccatttgc ccctgccgta 412501 aaatgattgt catgtcatcg attcccgatg gaacatgctc atacgtcaaa ccatgctcct 412561 ccaggatttg aagggctctg cggccaaaac cgatttctct gttcatgaga tacttgctga 412621 tataaatgct gcaaaaaccg gtgtcgctgg caatgccgac gacaggcccg tttgtgttat 412681 cccgcttgct gacgacgcgg gtgccttcgg ctgaggggtt gttcgtattt ttgatctgaa 412741 caggaatccc cgctctgaat gccggaatga gcgcttcatc atgaaacact gaaaaacccg 412801 cgtaggacag ctcccgcatc tctctatatg tcagctcgct gatttccttt ggattctcaa 412861 cgaaggacgg attgacagaa tacacagcgt ctacgtctgt aaagttttcg tacaaatcgg 412921 cttgtagtcc gttggcaaga atcgaaccgg taatatcaga accgctccgt gagaatgtga 412981 tcacatcgcc atccttgctg aatccgaaaa aaccgggaaa aatgatgagt ccgtcacgtt 413041 cccgaagacg atagaggttt tgataggatt caggaagaac ttgcgcgttg ccgggttcat 413101 ttgtcacaaa gaggccggca tccttcgggt ttacatattc cgctttgacg cctttataac 413161 ggaagtaagc ggcgatcagt ttggcattgt tatcctctcc gctggccttg actgcgtcaa 413221 ggtattgttc gggattgctt ttgtctcctt ctaaaagcgt aaacagatca tctctgattt 413281 tttcgataat gctttgcccc agctgaagct cattggcgat gagagcgtac cgttccacaa 413341 cagcttccgc cagttcaggt gcgctgcctg ttgccaaata ttgttctgca catgcgatta 413401 agagatcagt cactttcgta tcctcggcat agtgttttcc cggagctgaa acgactacag 413461 ctttccgtgc cggatctgag gtaacgatgt gaaacacctt gtcaagctgg gcgcctgaag 413521 caagtgagct gcctccgaat ttaacgacct tcatgtttac atctcctaat gtttaaaatt 413581 ttcacacaaa tttagtattt attatctctc tttcagtact gtaaatcaag ggggaatttc 413641 tttctcagga gaacatttgt atttttcacg aggaataatg ttaggtttgc tgaccgtatg 413701 cctgcgttat aaagataaat atggtaaaca gcctaacgtt ttgggatgga aaatggttag 413761 aatgattagt aaaattgata aatgactagg ttaatatttt taaagaatat tgactaaccc 413821 tataaaaatg gtaatatgta aatgataatg ataatcaatt actatatggc catattgttt 413881 tgagtccttg cggagtagga gatacgttct ttttgctgta aggatgtaag gaggcagcat 413941 gaagctacgt tacttattta ttctacttat catattagca gtcacatctg tatttatcgg 414001 tgtagaagat ctgtcgccgc ttgatctctt cgatttaagc aaacaagagg cgtcaacgct 414061 gtttgcaagc cgtttgccgc gattgatcag cattgtcatt gcgggattaa gcatgagcat 414121 ctgcggtttg attatgcagc agatcagcag aaataaattc gtgtcaccga cgacggcggg 414181 cacgatggat tgggcgaggc tcggcatttt aatttccttg ctgctgttta catccgccag 414241 tcctttaatc aaaatgctgg tcgcgtttgt ctttgccctt gcaggaaatt ttctgtttat 414301 gaaaatcctt gaaagaatca agtttaacga caccatcttt attccgcttg tcggtttaat 414361 gctcgggaat atcgtcagtt caatcgcgac atttatcgca tataaatatg acttgatcca 414421 gaatgtgtca tcatggctgc agggagactt ctctttagtc gtgaaaggaa gatacgagct 414481 tctttatctg agtattccgc tcgtcatcat tgcctatgtg tatgcggata aattcacatt 414541 ggccggtatg ggtgaaagct tttctgtcaa cctcggcctc aagtataaac gggttgtgaa 414601 catcgggctc attatcgtgt ccctgatcac gtctcttgtc attttgactg tcggtatgct 414661 gccgtttctc ggtttaatca tcccgaatat tgtatcgatt tacagaggag acaatctgaa 414721 gagcagcctg ccgcatactg tgctgttggg agcggttttt gtgctgtttt gcgatatact 414781 gggcagaatc attatcttcc cttatgaaat ctcgattggc ctgatggtcg gaatcatcgg 414841 cagcggcatt ttcctgttta tgctgttaag gagaaaagcc tatgcgtaac cagatgaaaa 414901 tagctttgct cgttggttta gccattgtat gtattggctt gtttttgttt tatgacttag 414961 gcaattggga ttacaccctg ccgagacgaa tcaaaaaagt cgctgccatt gtgctgactg 415021 ggggagcgat tgcgttttcg accatgatct ttcaaacgat tacgaacaac cgcatcctga 415081 cgccgagcat tttgggcctt gattctctct acatgctgat tcagactggc attatctttt 415141 tgttcggttc tgcgaatatg gtcatcatga ataaaaacat caactttatc atctctgttc 415201 tgctgatgat cctgttttct cttgttttgt atcagatcat gttcaagggt gaggggagaa 415261 atatcttttt ccttctgctt atcggaatcg tgtttggcac gctgttcagc agcctgtctt 415321 cttttatgca gatgctgatt gatccgaacg agttccaagt tgtgcaggac aagatgtttg 415381 ccagctttaa caatatcaat acggatttgt tatggctcgc gttcatcatc ttcctgctga 415441 caggcgttta tgtctggcgt tttacaaaat ttttcgatgt gctgtcgctc ggacgcgagc 415501 acgccgtgaa tttgggcatt gactacgaca aagtggtgaa gcagatgctg atcgtggttg 415561 cgattttggt ttctgtttca acagcgctag tcgggccgat tatgttttta ggccttctgg 415621 tcgtcaacct ggcgagagaa ttcctgaaaa catataagca ttcatactta atcgcaggct 415681 ccgttttcat cagcatcatt gcgctggtcg gagggcagtt tgtggttgag aaagtgttta 415741 ccttctcaac gacgctgagc gtcattatta attttgccgg cgggatttat tttatctact 415801 tgctgttaaa ggagaataaa tcatggtaga ggtcagaaat gtaagcaaac aatatggcgg 415861 gaaagttgtt cttgaagaga cgtcagtcac gattcaaaag ggcaaaatca cctcgtttat 415921 cggtcctaac ggcgccggca aaagtacgct gctgtctatc atgagccgcc tgatcaaaaa 415981 ggattccggc gagatttaca tagacggaca agagattgga gcatgtgaca gcaaagagct 416041 tgccaagaaa atgagcattt tgaagcaggc gaaccaaatc aatatcaggc tcacgatcaa 416101 agacctcgtc agttttggca ggtttccgta ctcacagggc cggctgacag aggaagactg 416161 ggttcatatc aaccaggcgc ttagctatat gaagctggaa gacattcaag acaaatactt 416221 ggatcagctg agcggcggac agtgccaaag ggcatttatc gccatggtca ttgcccagga 416281 cacagattat atctttctgg atgaaccgct gaacaatctg gatatgaaac actcagttga 416341 aattatgaaa ctgctgaaac ggctggtaga ggagcttgga aaaacgatcg tgatcgtcat 416401 tcacgatatc aattttgctt cagtctattc tgactatatc gtcgctttga aaaacggccg 416461 aatcgttaaa gaaggaccgc ctgaagaaat gatagaaaca tcagtgcttg aggaaatcta 416521 cgatatgacc atcccgattc agacgattga taatcaaaga ataggtgttt atttttctta 416581 atatatagaa gaggtgagga gcatgaaaaa gttcgcgtta ctattcatcg ctttggtcac 416641 tgccgttgtc atttctgcat gcggaaacca aagcacaagc agcaaaggtt ctgatacaaa 416701 gaaagaacaa atcacagtga aacaccagct cgacaaaaac ggcacaaaag taccgaagaa 416761 ccctaaaaaa gttgtcgtat ttgactttgg aagcttagat acattagata aactaggact 416821 tgatgatata gtagcgggcc tgccgaaaca agtccttcct aaatatctgt ccaaattcaa 416881 ggatgacaaa tacgctgatg tcggcagctt aaaagagcca gacttcgaca aagtggcaga 416941 attagatcct gatctgatca ttatttcagc aagacaatct gagtcttaca aagaattctc 417001 taaaattgcg ccgacgattt accttggtgt agatacagcg aagtacatgg aatcatttaa 417061 atcagacgct gaaacaatcg gtaaaatctt tgataaagaa gacaaagtga aagatgagct 417121 cgcaaacatt gatcactcaa tcgcagatgt aaagaaaacc gctgaaaagc ttaacaaaaa 417181 cggtctcgtc atcatggcga acgatggaaa aatcagcgcg ttcggcccta aatcaagata 417241 cggcctgatc catgacgtat tcggcgtggc tccggctgat caaaacatca aagcgtctac 417301 gcacggacaa agtgtttctt acgagtacat ttcaaaaaca aaccctgatt acttgtttgt 417361 tattgaccgc ggtacagcaa tcggagaaac atcatctaca aaacaagtcg tggaaaacga 417421 ttatgtgaaa aacgtaaacg cagtgaaaaa tggtcatgtc atctaccttg attctgctac 417481 ttggtattta tcaggaggcg gacttgagtc tatgacgcaa atgattaaag aagtgaaaga 417541 cggtttagaa aagtaaaacc aaaaagagcc tccgctaaat agcggggctc tttttttgtt 417601 aatcagcgtg ccggctgctg ttcggcaggg cgctgaggtt tctttaatgt gaatgagaga 417661 aggaagccga caagtgcaat gacggcagcc actataaaag cggcgttcat gccgtgcagg 417721 gcggcgtgct tcacatttgt cgtgcctgca tgtgccgcct ggttgctcat cacggaaacc 417781 aatagtgcgg ttccgatcga gccgccgact tggcgaatcg tgttgttcat cgcagttccg 417841 tgcggaatca agtggcgcgg cagcgcattg attccggctg ttgtcaccgg catcatgatc 417901 atggcggtgc ctaagagacg aacggtgtat aaaacgacaa tccaagcgag tgacgtatgg 417961 tcagtcagct gcataaacgg cagagatgtc aggaagatga tgcagaaacc ggcaatcgcc 418021 agccctcttc cgccgacacg gtcaaaaatt ctgccgataa tcggcgacat aaagcccatc 418081 acaacggctc ccggcaggag cataagccct gtatcaaaag ctgtgacgtc tctgacattt 418141 tgtgtataaa gcggcaggat ggtttccgta ccgatcaata atgcaaagac gagggttccc 418201 agcagtgttg ttaagctgaa aacgccaaac gtgaagacgc ggaattccag catcggtttt 418261 ttaagcttca tttgtcttgt gataaacaag agcagcgcga tgacacccac cagcagtgaa 418321 atcaagacgg ttgaactgga ccagccataa gagccgacgc ttgagaagcc gtacagaagg 418381 ccgccgaacc caaatgttga aaggatgact gataaaatat caatctgtgt ttttcttaaa 418441 gtcgtcacgt ttttcatcag gatgctggca agaatcaaat caatcacagc aaacggaaga 418501 ataatataaa acaatgatct ccaagagaaa gcttcgacag cccatccgga aagagtcggt 418561 ccgatcgcag gcgcgaatga gatgaccaat ccgaccatac ccatagcctg gccgcgcttt 418621 tcaatcggaa agattgtcag gaatacagtc tgcatgagcg gcatcataat gccggctcca 418681 gccgcttgaa tgatacgcgc tgtcagcaga accgggaagt tcggcgcgaa cgctccgacg 418741 actgttccgg cagtgaaaat gctcattgct gtgatgagca gcgcccggct tgtgaatttc 418801 tcaattaaaa acgcggtaat cggaattaaa atcccgttgg ttaacataaa tgatgttgtc 418861 agccattgtg cttggttggc atcgacattg aaatccctca tgatatgggg aagtgcagta 418921 atcaacaatg tctggttcaa aatcgccaca aacgctccgg ctaacaaaat gccgacaatg 418981 acagaacggt taaaaggttt ttgttcaata cttgtgttca atacatatcc cttcttttct 419041 ctaagtaatt aacagtgttt ttaacatgga aacgggctgt gttaaaacac cggtttgttc 419101 cagatagcca atcagtgatt tgagtaaaaa agcgcggggt tcttccttct tcgcttcttc 419161 ctccagcata gcggctgcgg atgtcagttc atctacgtca tagtccgcgg cggacaggga 419221 agagatgcct ttatgtaatt ccttcaggct ttccgataat aggactgatt tatcctttgg 419281 cttgtaggag gatgctgaat gaatataaag ctcgatggct tcgggcggaa gaagagactg 419341 gcgggtttcc ctgtttttga taatctgatt gagggtgctg atgataaact ctgcgatcgg 419401 gtcaagctca agcggttttt cctcgatttt gatcagcatt aaaaactcac gcatcatgcc 419461 gtgaagaatg ataaccaaat cccacacaaa cgggagaatg gtttctccat acgcctggat 419521 cagcgaatcg cggtgccagc agataatcgt cgatctggtc tgatggatat gctgtttgac 419581 ccggtcattg tgcagcttgg ggtttccgta ggtcagcata ttgaaaaact gctgattccg 419641 cctgaagccc tccagttcca ttttgacctt ttgcgtcaaa cgctcctccg gtgtaagtgc 419701 tgtattttcc tgaagtcttg aggccgcggc caccatttgc ttctggttaa atgacagcag 419761 ctccaaaagc agatcttctt tagattggaa cagcttatat atcgaagctt ttgacatctt 419821 acattcttct gcgatcgcct gcatggaaac cgacgtaaaa tccttttccg aaaaaagctt 419881 tcgcgcggct aacaagatat ctgttttttt atcaagcatc tcatggcttc cttctttctt 419941 gaacattaga aaacccattg gttcacagaa aaccaatgag taacaatgaa aaaattttac 420001 cagataaaca aaatagaagt caatggattt taaccgggta aatgaaaggc ctgccggaaa 420061 atccgacagg ccgaataaga gcttattttt caactttaaa tccttgtttt tcaagcattt 420121 cacggatgtg cggatagtac aggcgctcat agtaggaagc gatgctctgt gaccagtttc 420181 ttgtttcttt tccgtttgtc cgtttattca tgtattcaga catctgttcg tcgtatgcct 420241 gaatgtgaga cgtcagctca tcctgattca aataagtttc ctgatgattg acagcttcct 420301 gcggcaagcg cggttttttc gctgaacggt cggcaggatg cccaatgaca aggccggata 420361 aagggaacac gtatttcgga agctcaagca gttcgatcag ctcttgaggg tttccgcgaa 420421 ctgcaccgat cggaactgtg ccaagtccga gtgactcagc cgctgctgtt gctgtgccga 420481 gggcaatacc agcgtctact gcgccgacaa gaacagattc caatccattt gtgatttcca 420541 ttttgaaatc atgcagatct tcaagcgcaa ttttggcccg gttaaaatct gcgcagaaca 420601 gcaggaaaac aggagcttga tcgatccatg gctggccgcc tgccagctcg gagattttct 420661 ttttgcgctc tttatcctgg actgtgatca cagtcacttg ctgtccgttg atagaagaag 420721 gggctgattg caccgcttca atgatttggt ccaattgctc ctgagctaca ggctcatctg 420781 tgtagctgcg aatcgagcgg tggtctgtta aagatttaat cacttcattc atatgagaca 420841 cccttccttt actcgctaag ctctgtgcgg acaacatcaa gaggagcgct cagcagttct 420901 tttccttttg cgacaaaccc ttggaaatgc gcagtttcgt tatggaattt cattgccgct 420961 tcatctttcc atttttcaag catgacaaat gtattttctt cgcctacttt ttcgaatagg 421021 tcgtattgcg cgttgccttc ctcagctctt gaatgctgaa caagtgattg agcctcgctc 421081 aaaaattcct cgcgtttttc tggttttact ttgatgtaag cttgtaatac gatcatgtaa 421141 atctcctccg tcgttatgcg aatttattgt tcgaatttca tcgaactaaa tgtaacatgt 421201 attctaaatg aggtaaagga aaaaccctta tatagtaaaa ttgtcattct aattgttgta 421261 tgatacattt gtgtcatgaa cattccaaac catccagaaa cagaaacatt gcagctgaca 421321 aaggttcttc atgcacttag tgatccgctt cgtttagagc tcgtcaagca attagctgaa 421381 gcaaaagaaa aaacgtgcag cacctgtgca gatgtgcagg ttgccaaatc gactttgtcg 421441 catcatttta aagttttgag agaatcaggc atcgctcaag ttcggataga aggaaagcgc 421501 cggtattatt cgcttcgcgc tgaagacctt gaaaaggcat ttccgggact gcttgaagcc 421561 gtgctgaatg tagaccagga ccgctggtga atcaatcccc tgtaacgggg atttttttat 421621 gtccgtaaac cgctttgaaa agccgctgca caccctcctg aatatcttct tccttcagcc 421681 gtgcaaagcc gataatgaga gcaggcctgc ccgtttgccg cttgttttcc ttcaagttaa 421741 atcggctcat tccgaatatt tcaagctgca gcccggcagc atgtgacagg atgtcttgtt 421801 cggtgcgcct ggtatcaaat tcggtaacaa aatgcagccc cgcatttgcc ccttttacgg 421861 taacctctcc gctgaactct gcttctaaag cggtgatcag gcgttctctc ttttctttat 421921 aatgctgctt catttttttt atatgcttct gatattcacc agactcgata aattcctgca 421981 gggtgagctg tgtgagtgat gagcaagtct gcagatcata gccccgctgt ttgtatgccc 422041 tcaacagctc aggcggcaac accatatagc tgatccgtaa gccggggaga agggactttg 422101 aaaaggttcc catatagatg acattttgaa aacggtcgag gctttgcagc gccggaatac 422161 tgtctacatc atatgtgaat tcactatcat aatcgtcctc aatgatatat cggcgcggct 422221 cctcggctgc ccagttcagc agctgaattc ttctggatac aggcataatc gttccggacg 422281 gaaactgatg cgacggggtg gtcaccagca catctggctg ctgtctggtg atttcagcaa 422341 tcgacatgcc tttttcatcc agcatgatcg tctttacttg ttttccggca ttcttcaaaa 422401 gctgatacat gcgcctgtag ccaggctcct ccatcgcata cacggcttcc ttgggtaaaa 422461 gctcagtcaa cagctgcatg agcacctgtg tgcctgcccc tatgatcatt tgttccggcc 422521 tgcattttac acccctcgtc agggaaatga gcctcgtaat ggccgctctc acttcatata 422581 tcccttgcgg atgtgacata tcgccgagcg tgcggtatga gcgggaggcc gctttttgct 422641 cgcagcggaa ccagcttttg atcggaaaat ggtctgtatc ggaactcatg tgtgaaaacg 422701 atatccaatc gctctggtcg atgtgaatct cttttaggtc atccggcagt gcaaatggag 422761 ggtgctcctc ggcggaaaac atgtctagtt cctccacgaa gaaacccttt cgttcaatgg 422821 cgtacaaata cccctcagcc agcagctgct gataggctga attcactgaa tttacgctga 422881 ccttgagatt ttcagccagc tcccgcttgg agggaacctt cgagtgcggc agcagattgc 422941 ggctgaggat ttcttttttc agcttttgat aaatttgctg atagatataa tcggcttgtt 423001 ctgaacgatc gagtgtaatc gtgatatcca ttttgtagtt tctccttctg ataccatcaa 423061 aaagttataa ttggtacttt tcatcatacc aaagagaagt cagaatgata agaaaatacc 423121 gacaggggga tattcacatg agtcaaacaa cagcaagcat cacaactgca caatggcagc 423181 aaaaacggga tcaatttgtg tcaaaaggtg tgagcaacgg caaccgcagt ctggcggtca 423241 aaggagaagg ggccgagctg tacgatctgg atggccggag atttattgat tttgcaggcg 423301 ccatcggcac gttaaatgtc ggacactcgc atccgaaggt ggttgaggct gtgaagcggc 423361 aggcggagga gctgattcat cctggtttta atgtcatgat gtacccgact tatatcgaat 423421 tagcagaaaa actgtgcggc atcgcgccgg gcagccatga gaaaaaagcg atttttctta 423481 actcaggggc agaagcggtc gaaaacgctg tgaaaatcgc cagaaagtat acaaagcgcc 423541 aaggcgttgt ctcgtttaca cgcgggtttc acgggcgcac gaatatgacg atgagcatga 423601 caagcaaggt aaaaccttat aaattcggtt tcgggccttt tgcgccagag gtttatcaag 423661 cgccgttccc ttattattat cagaagccgg ccggcatgag tgatgaaagc tatgacgata 423721 tggtcattca agcattcaat gatttcttta tcgcttcagt ggcgcctgaa acggtggcgt 423781 gtgtcgtgat ggagccagtg cagggagaag gcggatttat tattccttcg aaacggttcg 423841 tacagcacgt cgcttcattc tgcaaagaac acggcattgt ttttgttgct gatgaaatcc 423901 aaaccggctt tgccagaact ggcacttatt tcgcaattga gcactttgat gtagtgcccg 423961 atctgatcac ggtttctaaa tcgcttgcgg caggcctgcc attaagcggt gtgatcgggc 424021 gtgcggaaat gcttgatgcg gcagcgccag gggagctggg cggcacgtat gccggcagcc 424081 cgctcggctg cgcggcggct ttggcagtct tggatattat cgaagaagaa ggactgaatg 424141 agcgatctga agaaattggc aaaatcattg aagacaaggc gtatgagtgg aaacaagaat 424201 tcccgttcat cggtgacatc cgcagactcg gggcgatggc cgcaatcgaa atcgtcaagg 424261 atcctgacac gcgtgagcct gataagacaa aagcagcagc gatcgcggcc tatgcgaatc 424321 aaaacggatt acttttgctg acagcgggaa ttaacggtaa tatcatccgc tttttgacac 424381 cgctcgtcat ctcagacagc ctattaaatg aagggctcag catcttggag gcgggcctgc 424441 gagcttaatc attggaaaga aaatggccgg gtctgctatc attttaagta atcatgaaaa 424501 gaaaggaatg ttcaatatgc cagatcaatt aacggtctac aacccggcta cgggcgagga 424561 gatcaaaacg attcctcagc aatcagccac agaggtagaa gaagccattg aacgttcaca 424621 tcaagcgttt aaaacgtggt ctaaaacatc agcgaacgaa agaacgtctc ttttgaaaaa 424681 atggtatgag ctgattgttg aacataaaga agagcttgca gatttaatta caaaggaaaa 424741 cggaaaacca taccaggaag cagtcggcga ggtactttac ggcgcaggct atatcgaatg 424801 gttcgcagag gaagcgaagc gtgtgtacgg aagaacggtc ccggccccga caactggtaa 424861 acgaattgtt gtcacacgcc agccggtcgg ccccgttgct gctatcacgc cctggaattt 424921 cccgaatgcg atgattacac gcaaagcggc gcctgctctt gccgccggct gtacatttat 424981 catcaagccg gcgccggaca caccgctgtc tgcttatgaa ctagcgcgcc tcgcatatga 425041 agcgggcatt ccgaaggatg ttcttcaggt tgtgatcggc gatggagaag aaatcggaaa 425101 tgtgttcaca agcagtccga aaatccgcaa aatcacgttc acaggctcaa cacctgtagg 425161 gaaaatcctt atgaaaaaca gcgctgacac cgtaaagcac gtctcaatgg agctcggcgg 425221 acacgccccg ctgatcgtag atgaagatgc ggacattgac cttgccgttg aacaggcgat 425281 ggcgtccaaa taccgaaacg ccggccaaac ctgcgtatgt gccaaccgcc tgatcgttca 425341 tgaatccatt aaagatgaat ttgctgcgaa actgagcgag caagtgtcta agctgaaagt 425401 cggaaatgga cttgaggaag gcgtcaatgt cggcccgatt atcaacaaac gaggcttcga 425461 aaaaatcgtc agccaaatag atgatgcggt tgaaaaaggc gcgaaagtga ttgctggggg 425521 cacatatgac cgaaacgatg acaaagggtg ctactttgtg aatccgacag tgctcaccga 425581 tgtcgatacg tccatgaaca tcatgcatga ggaaacattc ggcccggtcg ccccgatcgt 425641 cacgttttct gatattgatg aagcgattca gcttgccaac gatacaccgt atggcttggc 425701 tgcttacttc ttcacagaaa actaccgccg cggcatctat atttccgaga atctagagta 425761 tggcattatc ggctggaatg acggcggacc gtcagcggtt caagcgccat tcggcggaat 425821 gaaagaaagc ggcatcggcc gtgaaggcgg ttcagaaggt atcgagccgt accttgaaac 425881 aaaatatttg tccatcggtt tataaaagaa tgcacgctcc tgagagctgc cggattttcc 425941 ggcagctctt tttgtgttcc ggcgaataat cacaacaatt ccagccaaaa taacagcaaa 426001 tacattttga aagaaggttc cccaacaatg gatttattat tggctcttct cccggctttg 426061 ttttggggga gcattgttct cttcaatgtg aaattaggcg gcgggccgta cagccagaca 426121 ctgggaacga cgatcggggc actcattgtt tctatcgtta tttacttttt tgttcagccc 426181 gttctgtccc ttcgcatttt tattgttgga atcgtatccg gcttattttg gtcacttgga 426241 caggccaacc agttgaaaag cattcaattg atgggcgtgt cgaaaacaat gccgatttcc 426301 acaggaatgc agctcgtttc cacctcgctg ttcggtgtga tcgtgttccg cgaatggtca 426361 acaccgattg cgattacgct tggcgttctc gctttgatct ttatcattgt gggaatcatt 426421 ctcacgtcct tggaagataa gaatgataaa aaagagggcg agccaagcaa tttgaaaaag 426481 ggcattttga ttctccttgt ttcgactctt ggttatttgg tttatgtagt cgtggctaga 426541 ttattcaatg tgtccggctg gtccgcgctg ctgccacagg caattggcat ggtggtcggg 426601 gggttagttt taacctatag acacaaaccc tttaacaagt atgcgatcag aaatattctc 426661 ccagggttaa tctgggcagg cggaaatatg tttttgttta tttctcagcc gcgagtcggc 426721 gttgcaacga gcttttccct ttcacaaatg ggaattgtca tttctacgct cggcggtatt 426781 ttcatcctgc gtgaaaagaa aacgaaacgc cagctaatag caattgcgat cgggattatc 426841 ctgattattg ccgccgccgt attcttagga atcgccaaaa caaattcata acaaatggag 426901 gaggatgtat atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc 426961 agggctcgga aaggcgatgg ccattcgctt cggcaaggag caggcaaaag tggttatcaa 427021 ctattatagt aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg 427081 tgaagctgtt gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca 427141 aacggcaatt aaggagttcg gcacactcga tattatgatt aataatgccg gtcttgaaaa 427201 tcctgtgcca tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt 427261 aacgggtgcc tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa 427321 gggaaatgtc attaacatgt ccagtgtgca cgaagtgatt ccttggccgt tatttgtcca 427381 ctatgcggca agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc 427441 gccgaagggc attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc 427501 tgaaaaattc gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggata 427561 tatcggcgaa ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag 427621 ctacgtcaca ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca 427681 ggcaggccgc ggttaaacat aaaaagcgac ccagacatga catctggatc gctttcttta 427741 ttaggcacgc tttttcttta caagtgctgc tacagataaa ataatggcag ccgcagacag 427801 caccatcgct gtaatgtcta gagctgaaga acctgagttt tcggaatcgt cttctgtttt 427861 cgtggcgccg tgctcatctg tcacttgctt tgcagacgtg atgtttgtaa tggaatgagg 427921 tgtatcggca tcctcgtcac ctgtccactc aacaatgctg ccgtctttgt aatattggta 427981 tgcgtcccaa gcagcttcct ccgctttgtc agggtttttg gcaacaaagg taaactgctg 428041 gaactggcct tcctgaatgc ctccgtcagt cgcctcccat gtcacggata ctgatttgtc 428101 atcatgtttt tgagtggaaa ccttccagcc cggaattggc tcatattgct ggaattcaac 428161 atccttcggc attttgagga caaccttcgt tgtcggcaga tttttctcag aaggaacctt 428221 cattgtatac gtttcccaag agcctgcagc agactcagcc ggttttacag aaacatgcgc 428281 gctggcaggg gccgtaaaga ataagaggga gccgacaata gccggacata gtgtcaatgc 428341 gatttttttc aacaacgtaa acactcctta attggtcttt gtaaacatga tattgatttc 428401 gttaaagtcg ccggtcaggc cgtggacttt gatcttccag tttccttttt cattaatcga 428461 caggttttga tcttggaaga cgccttttgt tttttctttt aatgtaaagg tgcttttgtt 428521 ttcgctgcct gacaggcctg ttttataaac ggttaacgtg atttgctgga tgtttttcac 428581 gggatcaccg ttatggtcgg tgacccgcag ctcaaaaaca ttttttccag gctggtttgg 428641 gctgatgctg agagaaacgc tttgtccgtt ctctatcgct ttggtttggt agaacggttc 428701 cggcgctggc tcaggcgggc ttggcaggct tgtaaacacg gccgctgtga tcaatacagc 428761 gatgccgatt gcccactccg ctttcaacgt tcggctgatt cctgtgcggc gctgctttct 428821 ggtaagcaga aaatgaattg cgcctaagac cagcatgaaa acaaacagcc cgcttttcac 428881 taaaagagct tgtccgtacg ctgtatggaa cagtgaatcc attgaacgaa tgatgaaaaa 428941 tccattgagc aagcctgaaa acaaaatgac gccgactgca gtgagcgccc atggggagaa 429001 ccgtctgacc gtctcccacg cgagcgtttt gtcaggctgc ctccattctt ttgagagcag 429061 caaaacgagt gccgctattc cgccgaccca gatggaagcg gaagttaaat gaaggaaatc 429121 catcaaaatg ccgaccgttt tttcttcaac gacagcagca tgcccggtaa acgccttggc 429181 aagcaggaga ccgaaaaaga aaatgagcgg cgctgtccaa tagccaaagg atgaaaagcg 429241 gtttttccgt atcgcaggga tgacagacag tgcgagcagc acgaacagcg cagcctgtat 429301 gatccaaatg gagccgcctg ctgtctcaaa cagtgtttct ctgatgtagc ccggctggaa 429361 tgcgctgccc cagccgccgc ctgcgttcgc ttttgtctga atcggaagct gaagcaaaag 429421 cgccagcccc aatgctgcga tcgagccggt caggatacgt ctcgtccgtt tgacgagctg 429481 ttctgatttc cctttatacc agaaaagatg gaagaaaacc gttccgataa acagagataa 429541 ggctgtatac agaatcgcgc gatctgctgc tgttcccgga ttcagcgctg aatcggctgc 429601 tttttggctg ctgaatccgc catccgcttt cccgatactg aacggaatga cgccggaaac 429661 aggatgtcca tccgcggata cggcattcca ttccgctctg tacacatctt taggcagatt 429721 cttcttcagc ttcactgtca tgatgtgatg attatctttt ttgatttcag tcttgtccgt 429781 atccacacgg tcgccgtttg aattatagac tttaatgtaa tgaaaccctt cttcaaccgg 429841 ttcattaaat tcgatttcca cctgcgcagg ggcgcttttt aattcgctgt tttccccagg 429901 tgaagatttg acaatatagg cgtgagcaaa gcttgttttc ggcaggaaaa caagaaaaag 429961 cagaaggatg atccaccatc tgtttcgctt catcactcag acaccacctt ccgctgtatg 430021 tgttgtgtta tttcttggtg caggtgcagc gtttctttcg gtcttgaagc atgtcttcca 430081 gcgcttggtc gaaagtgcag acggctccgc cgaatccttt ttgaaatcgt tcggcatggt 430141 caagtgtcgc aaacggaatg gcctgcggct ggcagcagtg caggtttaat tcagcattta 430201 cgacgaaata agccgaaccg gcactgacgg ttgtctgtaa cagaaaatct ctgcaaatca 430261 agtgtgaaac ctcttccgtt ttatccgcgt aacgcaaaaa cgcgcaatgt gcgcagcata 430321 gctgttcaat gtcttggttt accgtaatca gctgaaccga atgagcttga ttgacgggct 430381 tcaagcaata gctgcacata tgatctgttt gaggtgttcg gacggggagc gtgatgccgc 430441 cggccgtttt aatgacctga tttgactgaa ccagctgatt gacatctcta tataccgtca 430501 tttccgaaac gccgaacctt gcgctgatgt cagaaattct aagcgagcct tcttctttca 430561 gccacttcag tatgtgttgc tgtctattaa tcggaagcat tcatacaccc tcttcattaa 430621 gatctattta agcgtagagg attttagaga cggagacaag taagtggatg ataaaaaatg 430681 tgaaaatgtg ttgaacagca acaaaacgaa acagaaggga ctctggtata atagacagat 430741 ggaatagaaa gtgaggaata ccctatgaaa gaaacaccat gcccgaactg cggcaaacct 430801 ttgacaggcg atatggtcag atcatcaaat gtgccttgtc aatttcgctg cggccactgc 430861 cgggaacggc tttatgaata taaagtttca gctccgatta tgctggtatc attagcggcc 430921 atcgtgctgc ttatttatct tttgatgctc ctccgcaatg cggcaggctc agtgctgcca 430981 gctgtacagc acgtgccgat ggctgtattt gcgcttgtgt gcgcgtatcc cgtttttatt 431041 gtgagtgagc ggatgattgc aaagtacgtg attcaaaatg gcaacatcat ttatagagga 431101 aagagaaaag gctcctgaaa ccaggagcct ttttattttt aaaaaattgt cacagtcatg 431161 tgccaaagtc ctctttactt tcaattgtat agggactgta agcgttttaa catagagtca 431221 aagggaagca tcattctctg aacatatttt tgtatcttac agcgacaaac aaaacaggga 431281 gggtttatat atgcagcagc aagaacagca gcaaggcggc atgaaagtga aagtgcaacg 431341 ctttgggagt tatttgagcg gaatgatcat gccgaatatc ggcgcgttta tcgcgtgggg 431401 tatcattacc gcgctgttta ttccggcagg atggtttccg aatgaacagc tgaacacgct 431461 ggtcagcccg atgattacgt atttattgcc gcttttgata gcgtatacag gcggaaaaat 431521 gatctacgac caccgcggcg gagttgtcgg agcgacagcg gcaattgggg tgattgtagg 431581 atcggatatt ccaatgtttt taggcgcaat gattatgggt ccgcttggcg gatacctcat 431641 taaacagact gataaattat tcaaggataa agtcaagcaa ggctttgaaa tgctgatcaa 431701 caactttacg gcagggattg tcggcgcggc tttaacgatt ctcgcgtttt acgccatcgg 431761 cccggttgtc ttgacgctaa ataaattgct ggcggctggt gtggaagtca ttgtacacgc 431821 taatttactg ccggtagcca gtgtttttgt agaaccggcg aaagtgttgt tccttaacaa 431881 cgccataaac catggaatct taagcccgat cggaatcgag caagcatctc aaacaggaaa 431941 atcaattctg tttttagtag aagcaaaccc tggaccgggg ctcggcattt tgctggccta 432001 catgttcttt ggcaaaggat cttcaaaatc aacggctccc ggtgcggcga tcatccattt 432061 cttcggaggg attcacgaga tttacttccc gtacattctg atgaaaccgg ccctgattct 432121 cgcagccatt gccggcggag caagcggact cttaacattt acgatcttta atgccggact 432181 tgtcgcggca gcgtcaccgg gaagcattat cgcattgatg gcaatgacgc caagaggagg 432241 ctatttcggc gtattggcgg gtgtattggt cgctgcagct gtatcgttca tcgtttcagc 432301 agtgatcctg aaatcctcta aagctagtga agaagacctg gctgccgcaa cagaaaaaat 432361 gcagtccatg aaggggaaga aaagccaagc agcagctgct ttagaggcgg aacaagccaa 432421 agcagaagaa gcgtctgagc tgtctcctga aagcgtgaac aaaattatct ttgcgtgtga 432481 tgcgggaatg ggatcaagtg ccatgggggc atccatctta agaaacaaag tgaaaaaagc 432541 ggagcttgac atcagtgtga ccaacacggc cattaacaat ctgccaagcg atgcggatat 432601 tgtcatcacc cacaaagatt taacagaccg cgcgaaagca aagctgccga acgcgacgca 432661 catatcagtg gataacttct taaacagccc gaaatacgac gagctgattg aaaagctgaa 432721 aaagtaatct tatagaaaga gagtgattgt catgcaagta ctcgcaaagg aaaacattaa 432781 actcaatcaa acggtatcat caaaagaaga ggctatcaaa ttggcaggcc agacgctgat 432841 tgacaacggc tacgtgacag aggattacat tagcaaaatg tttgaacgtg aagaaacgtc 432901 ttctacgttt atggggaatt tcattgccat tccacacggc acagaagaag cgaaaagcga 432961 ggtgcttcac tcaggaattt caatcataca gattccagag ggcgttgagt acggagaagg 433021 caacacggca aaagtggtat tcggcattgc gggtaaaaat aatgagcatt tagacatttt 433081 gtctaacatc gccattatct gttcagaaga agaaaacatt gaacgcctga tctccgctaa 433141 aagcgaagaa gatttgatcg ccattttcaa cgaggtgaac tgacatgatc gccttacatt 433201 tcggtgcggg aaatatcggg agaggattta tcggcgcgct gcttcaccac tccggctatg 433261 atgtggtgtt tgcggatgtg aacgaaacga tggtcagcct cctcaatgaa aaaaaagaat 433321 acacagtgga actggcggaa gagggacgtt catcggagat cattggcccg gtgagcgcta 433381 ttaacagcgg cagtcagacc gaggagctgt accggctgat gaatgaggcg gcgctcatca 433441 caacagctgt cggcccgaat gtgctgaagc tgattgcccc gtctatcgca gaaggtttaa 433501 gacgaagaaa tactgcaaac acactgaata tcattgcctg cgaaaatatg attggcggaa 433561 gcagcttctt aaagaaagaa atatacagcc atttaacgga agcagagcag aaatccgtca 433621 gtgaaacggt aggttttccg aattctgccg ttgaccggat cgtcccgatt cagcatcatg 433681 aagacccgct gaaagtatcg gttgaaccat ttttcgaatg ggtcattgat gaatcaggct 433741 ttaaagggaa aacaccagtc ataaacggcg cactgtttgt tgatgattta acgccgtaca 433801 tcgaacggaa gctgtttacg gtcaataccg gacacgcggt cacagcgtat gtcggctatc 433861 agcgcggact caaaacggtc aaagaagcaa ttgatcatcc ggaaatccgc cgtgttgttc 433921 attcggcgct gcttgaaact ggtgactatc tcgtcaaatc gtatggcttt aagcaaactg 433981 aacacgaaca atatatcaaa aaaatcatcg gtcgctttga aaatcctttc atttcggacg 434041 atgtgacccg cgtagcgagg tcacctctca gaaaactggg agaaaatgat agacttgtag 434101 gcccggcaaa gaaaataaaa gaaccgaatg cactggctga aggaattgcc gcagcactgc 434161 gcttcgattt caccggtgac cctgaagcgg ttgaactgca agcgctgatc gaagaaaaag 434221 gatacagcgg cgtacttcaa gaggtgtgcg gcattcagtc ccatgaaccg ttgcacgcca 434281 tcattttaaa gaaacttaat caataaccga ccacccgtga cacaatgtca cgggcttttt 434341 ttactatctc gcaatctagt ataatagaaa gcgcttacga taacagggga aggagaatga 434401 cgatgaaaca atttgagatt gcggcaatac cgggagacgg agtaggaaaa gaggttgtag 434461 cggctgctga gaaagtgctt catacagcgg ctgaggtaca cggaggtttg tcattctcat 434521 tcacagcttt tccatggagc tgtgattatt acttggagca cggcaaaatg atgcccgaag 434581 atggaataca tacgcttact caatttgaag cagttttttt gggagctgtc ggaaatccga 434641 agctggttcc cgatcatata tcgttatggg ggctgctgct gaaaatccgg agggagcttg 434701 agctttccat taatatgaga cccgccaaac aaatggcagg cattacgtcg ccgcttctgc 434761 atccaaatga ttttgacttc gtggtgattc gcgagaacag tgaaggtgaa tacagtgaag 434821 ttggcgggcg cattcacaga ggcgatgatg aaatcgccat ccagaatgcc gtgtttacga 434881 gaaaagcgac agaacgtgtc atgcgctttg ccttcgaatt ggcgaaaaaa cggcgcagcc 434941 atgtgacaag cgccacaaag tctaacggca tttatcacgc gatgccgttt tgggatgaag 435001 tctttcagca gacagccgct gattatagcg gaatcgaaac atcatctcag catattgatg 435061 cgctggccgc tttttttgtg acgcgtccgg aaacgtttga tgtcattgtg gcgagcaact 435121 tgttcggtga tattttaacc gacatcagct caagcctgat gggaagcatc ggcattgcgc 435181 cttctgcgaa catcaatcca tccggcaaat atccgtccat gtttgaaccg gttcacggct 435241 cagctcctga cattgccgga cagggccttg ccaatccgat cggccagatt tggacagcga 435301 agctgatgct cgaccacttc ggagaggaag aattgggggc gaaaattctg gatgtaatgg 435361 agcaagtgac tgccgacggc atcaaaacac gcgacattgg gggacaaagc acaacggctg 435421 aggtcactga tgaaatctgt tcgcgcttaa gaaagctctg atgaatcagg ccggtggcag 435481 atggctgccc cggcctgtcc atttccttac gaaaatttcc acgaaagtct aaccaagcag 435541 atccaaatgc tgtataataa tttggaattc ttaggaaagc atcgggtgaa ggaagttgaa 435601 tgcaaaaaca atcacgttaa agaaaaaaag aaaaatcaaa acgatcgttg tactcagtat 435661 cattatgatc gcagctctca tttttacgat cagattggtg ttttacaagc cttttcttat 435721 tgaaggatca tcaatggccc caacgcttaa agactcagaa agaattctgg ttgataaagc 435781 agtcaaatgg actggcgggt ttcacagagg agacatcata gtcattcatg acaaaaagag 435841 cggccgctca tttgtcaaac gtttaatcgg tttgcctggt gacagcatta aaatgaaaaa 435901 tgatcagcta tacataaatg ataaaaaggt ggaagaacca tacttaaagg aatataaaca 435961 ggaggtcaaa gagtcgggtg taaccttaac aggtgacttc gaagttgagg ttccttccgg 436021 taaatatttt gtgatgggag ataaccgtct caattcactg gatagcagaa acggaatggg 436081 catgccttct gaggacgata tcatcggtac tgaatctctc gtcttttatc cattcggtga 436141 gatgagacag gcaaaataaa atgcaatgca aaaagaacat ggaacatgac ggcaccgata 436201 ataaagcgcc gtgcacgttt aaaaaaatga tgatgaaacg gtgcggagcc ggctttccgc 436261 cccgtttttt atgatagaaa gcgttttgaa gaaaagggcc ctgttgaaat aaacagaatc 436321 aggattggcg aagccgtgaa gcgcatcgaa ttggtaaatc tcaagatggg tatgctgttt 436381 ttcccgcagt tttttgataa gaagcgctac gtcaaacgac ggctcataat tagggaaaaa 436441 caataggacc gggcaggctg gcatgtgatg aagagagtcg cgtatccggg aaccgtaata 436501 acaaaccgat ccgctcacct caggcatact gctgcatttc catgcgatag tagcccccac 436561 gctgaatcca atcacaaaga tgtgccgtcc ggcgttttgc ctgatcacat tctggatgat 436621 ggtttctccc gttttcagcc tttcgtgttt tgtaaattgt tcgtatgccg ttttttcttc 436681 tttcagtgtg tagacttcat cctcgccgag caggttgggc gtcaacacat catatccagc 436741 cattttgatc agccggccca tctttttcat atggctgttt acaccatata tttcgtgtgc 436801 gagaatgaca agcggttttg ggaacataac ggcctccttt tgtgtttttt ccattatatc 436861 ctatcgtttc actttaggct gagatataat ggtcaaaaaa aggagatata aaatgaactc 436921 attatctttg cctcaccgct atccattttt gtttattgat ggcgtgacgg atagcgagcc 436981 cggcaaacat gcggcagctt ataagctgat tagtgagaac gactggttta tcactgatac 437041 gcaaacagaa atgccgtttt cacttgtgat tgaagcgctt gcgcaaaccg cggcttttac 437101 aggaattaca gatgagaaca gcttgggatt attgtcttcg gtgaagaaag cggaaaagct 437161 gggagaagct gtgcctggtg accggcttga tcttacgttt gaagtcacgc gcaatcggcg 437221 cgggtttgtg ttcggacatg ccaaggcatc agttggagag cagcctgttg ctgaagctga 437281 aatcggcatc tatattgaaa aatgaaaaaa acccttcaca acattttgtg aggggttcta 437341 ttttgtgtcg taatcccgtt cgctttgaga gttatctctt tgctggcgtt tgtgtttttc 437401 atcattcata ttttccttca gctcttcatt aggaatcgga tcggttaagt cgttgtgctc 437461 ggggttttca tttggtttgt tttgctgttt tttttctgtc atgtttgatc acctcaccgt 437521 ttgttttcct cttattcatt ctcctcaaac ataggaaatc gcttttttgt cccgctgggt 437581 ataatgtatt agaatagaga gaagcacaac aaaaagataa agagaggtac atatatgtct 437641 gttcaaagag aagatgtaga tatcaagctg atcgcaattg atatggatgg tacactgctg 437701 aacgacgagc agctgatctc ggatgaaaac cgcaaagcca ttcgtgaagc ggaggataaa 437761 ggtgtgtatg tggtgatcag cacgggccgg acgctgatga cgtgcaggga gctggcggaa 437821 tcgctaaagc tgtcatcctt tctaatcacg gcaaacggca gtgaaatttg ggattcgaat 437881 tttaatttgg tggaacggaa gctgcttcat acggaccata ttcaaatgat gtgggatttg 437941 cggaataagc acaacactaa tttctgggct tctacggtga ataaagtatg gagaggcgag 438001 tttccggaaa acattacgga tcatgaatgg ctcaaattcg gctttgacat cgaggatgac 438061 gatatccgaa acgaagtgct tgaggagctg agaaaaaaca aagagctcga aatcacaaat 438121 tcaagtccga caaacattga agtcaacgcg cttggcatca acaaagctgc agcccttgcc 438181 aaggttacgg aaaaactcgg ctttacaatg gagaatgtga tggcgatggg cgacagcctt 438241 aatgacattg cgatgatcaa agaagcgggt cttggcgtcg caatgggcaa tgcgcaagac 438301 atcgtaaaag aaacggctga ttatatcacg gatacaaata ttgaggatgg tgtcgctaaa 438361 gcgattcgcc attgggtact ataaaaaaag agagtcctaa gatggactct cttttttagt 438421 ttggcaggtt ttattctggg accatggtag gttttctgac aaaagtattt cacaaactga 438481 tatgattcac ttataatgaa ataaagttca aaaattcgga atagtcgttc cgaatttcgg 438541 gacaataaat gacataaagc atatcgtttg ctttggcagg agggattctg tgtttcagat 438601 tgatttaaac tgtgatttag gagaaagctt cggagcctac aagataggcc ttgaccaaga 438661 tattttagag tatgtgacat cagcgaatat cgcatgcgga tttcatgcag gagatcctag 438721 tgttatgcga aaaaccgtcg cgcttgcagc agaaagaggc gtgaaaatgg gtgcgcatcc 438781 gggcttgccg gatttactcg gttttgggcg ccgcaatatg gcgatttctc ctgaggaagc 438841 gtatgatctt gtcgtttatc aaattggcgc gctctctggc tttctaaaag cagagggact 438901 tcacatgcag cacgtcaagc cgcatggcgc tttatacaat atggcggcag tcgatcaaaa 438961 actgtcggat gctatcgcga aagctgtcta taaggttgat cccggcctga ttcttttcgg 439021 tcttgctgag agcgagcttg taaaagcggg agaacggatc ggacttcaga ccgcaaatga 439081 agtgttcgcc gacagaacat accaatcgga cggcacgctg acaccgcgct cccagccgga 439141 cgcactcatt gaaagtgatg atgccgccgt cacccaggtc atcaaaatgg tgaaagaagg 439201 ggcggtcaaa tctcagcaag gacatgatgt gtcattaaaa gcagatacag tctgcattca 439261 tggagatgga gcccatgcgc tgacatttgc gcaaaaaatc agaaaacagc tcaaagcggc 439321 tggaattgaa gtgacagcta tttcagaaca gaggtcaaca taaaggagga acaatagatg 439381 gagcagcaga aaaagacagc aggaaaaaaa gcgggcagct ggtcattgct gatgggcgcc 439441 gcctttttaa tggcgacatc agcaatcgga ccgggtttcc tcacccaaac cgcaacattc 439501 acaaacacac tcgcagcaag cttcggtttt gtcatcttaa tctctattat tttagatatt 439561 ttcgcccaaa ccaatgtgtg gcgcatcatc gcagtttctg gaaaacgagg tcaggaaatt 439621 gcgaatatgg tgcttcccgg actggggtat ttcatcgcca ttctcgtcgt gcttggcgga 439681 ctagctttta atattgggaa tatcggaggg gccgggctgg gacttcaggt gctgttcggc 439741 attacacctg aaacaggcgc tttaatcagt gccgttatcg ccattttgat ttttgtcatc 439801 aaggaagcag gaaaagcgat ggaccgtttt acgcaaatcg cggggttcgt gatgattatt 439861 ttaacggtct acgttgcggc gacgacagct cctccggtcg gacaggcagt cgcaaataca 439921 ttcgtcccgg aacacatcag catatttgcc attgtcaccc tagtgggcgg aaccgtcggc 439981 ggttatatca catttgccgg aggacaccgt ttgcttgatg ccggaattaa aggaaaggaa 440041 tccattccgc aggtgacaaa gagctcggtt gtcggcattt taattacatc tgtcatgcgt 440101 atcgctcttt ttcttgcggt tctaggcgtt gtatcgaaag gcctgcacat cgatgaaagc 440161 aacccggcgg cttctgtctt caagctggct gctggaaatg tcggttataa aattttcgga 440221 ttgatcatgt ggtctgcggc gattacgtct gttattggag cagcctatac atctgtttca 440281 ttttttaaaa ccttttctcc aaaaattgaa aagaattcac gcggtattat tatcggattt 440341 attgtggttt ctacgttagc ttttgtcaca atcggccagc ctgcgaagat cctcgtcctt 440401 gtcggttcac tgaacggctt aattctgccg attgcgctcg gaacgctgct tgttgccgcc 440461 tacaagaaaa acattgtcgg tgattataag catccgcttt ggctgacaag cacaggcgcg 440521 cttgtagtga ttgtaatggc agttatggga atctacacgt tatgtacaca acttcctcaa 440581 ttgtggagct gatataagtg gagcaattaa acaaaatggc gccaaaggat gtacgcgccc 440641 tgatacgaga ggggaaaata aacgggccga ccgcaggcat gtccggcggc tacgcccaag 440701 cgaatcttgt ggttttgaaa aaggaccttg cgtttgattt tctgctgttt tgccagcgaa 440761 atcaaaagcc ctgccccgtg ctggatgtga ctgaagcagg ttcgcctgtg ccgtctctgg 440821 ctgcgccgga tgctgatatc agaacggact ttccgaaata ccgtatttac aggcacggta 440881 tcctaacgga agaagtatct gatattacgc catactggga ggacgatttt gtcggctttc 440941 tgatcggatg cagtttctcc tttgaacagg cactgatcaa taatgggata gctgtccggc 441001 atattgatga ggggacaaac gtctcaatgt ataaaacgaa tatcgattgt gttccggcgg 441061 gggcgtttca cggacagatg gttgtcagca tgaggccggt tcctgaacgg ctggctgtac 441121 gtgctgcaca agtgacctcg cgttttccgg ctgtgcacgg agggccgatc catattggca 441181 atccgggagc aatcgggatt cgcgatctcg ggaaaccgga tttcggagat gccgtttcca 441241 ttcgtgacgg cgaggttcct gttttttggg catgcggagt gaccccgcaa gccgtggcta 441301 tgaatgtaaa gcctgaaatg gtcatcacac atgcgccggg gcatatgctc atcacagata 441361 ttcgagacga gtcgcttgcg gtgctgtagc ctctcgtcat cctgatgaac gagaattaaa 441421 agaggtgaga aagatgactg tacgatatca aatcgaacag ctcggtgatt ctgcaatgat 441481 gatccgattc ggagaagaaa tcaatgaaca ggtcaacggc attgtccatg cagcggccgc 441541 ttatatagaa gaacagccat ttccgggatt cattgaatgt atcccggctt ttacaagtct 441601 aaccgtattt tatgatatgt atgaagtgta caagcatttg cctcaaggca taagctcacc 441661 ttttgagagt gtcaagcgcg atgtcgaaga gcggctggca gaaatagccg aagactatga 441721 ggtcaaccgc cgtattgtag aaattcccgt ttgctatggc ggtgaattcg gtccggattt 441781 agaagaggtg gcgaagatca atcaactgtc accggaggaa gtaatcgaca ttcatacaaa 441841 cggtgaatat gtggtgtata tgcttggctt cgcgcccggt tttccttttc taggcgggat 441901 gtcaaaacgc attgcagctc cgagaaaatc atcgccaaga ccgtcgattc ccgcaggttc 441961 ggtcggtatt gcgggattgc agacaggcgt ttatccgatt tcaacgccgg gcggctggca 442021 gctgatcggc aaaacgccgc tggctctttt ccggccgcag gaaaacccgc cgacattgct 442081 gcgggcggga gatattgtga aattcgttcg catctcagaa aaagactatc acgcctataa 442141 ggaggagtcc aattgagcat gaaagtatta aagcccggac tgctcacaac ggttcaggat 442201 ataggcagaa cgggttacca aaaatacggc gttctggcca gcggcgctat ggacacggtt 442261 tcactgcgca ttgccaatct gttgatagga aacggcgaaa atgaagcagg tctcgaaata 442321 acgatgatgg ggcccggtcc gtcgtttcat ttttcaaaac agacactgat tgctgtgaca 442381 ggggcggact tcacgctgcg tattaatgac gaggaagcgc ctttatggaa gcctgtgctc 442441 atcaaggaaa acagcacggt cagctttggc ccctgcaaac tcggcagccg tgcttatttg 442501 gcggcagctg gcggcattga ggtgcctgcc gtcatggaaa gtaaaagcac atacgtcaga 442561 ggaagcattg gcggacttca tggcagagcg cttcaaaaag aagatgaact gaacattgga 442621 gagatgtcag ctctttcgca aaccatcctt tctcgcttaa gttcgcagct tggaaaacag 442681 ggatttgcag caccgaagtg gtcagtcagc cgcggcagat ttctgccatt gaagaagaat 442741 cccgtcattc gggtgctgga aggaaagcaa tttgcctttt tcacagaaga atcaaaaacg 442801 cgtttttatg aagaagcatt tcgtgtcacg ccgcagtccg accgtatggg ctacaggctc 442861 aaaggagaac cgctcgaact gaaggccccg cttgagatgg tgtcggaagc ggtttcattc 442921 ggaacagttc aggtgccgcc tgacggcaac ccgattatcc tgcttgcaga ccggcagacg 442981 actggcggct atccgaggat cgcgcacatc atatccgctg atcttccgat tgtttcccaa 443041 atcatgccgg gcgagcacgt tcagtttgag cctgtgtccc tccaggaggc agaagcgctt 443101 gcggtagaac gggaacagca tataaaagaa ctgaaaacga gaatgaagat ggaatggctg 443161 acatagcaaa ggggatgaat gatgcagaat aaaaataaaa ccgtagtcaa atctatggcg 443221 ctgcttaatt tgtttttgca taaaccaagc ctaaccttaa gtgaactggt gtcgctgacg 443281 ggaatgccga agacctctgt tcaccggatg gtcagctcct tggaggaaat ggggttcctc 443341 agtcgggatg cgtccggcgc ttattcgctg ggattggtgt ttttggaatt cggacagctt 443401 gtcgctgaca ggctggatat cagaaaaata gcgaaaccgg tgatggaaga gctgtgccgg 443461 gaagtggatg aggccgtgca gttgatcatg agggacggca atgaagcgat atacgttgag 443521 aaaatagaag ggacacagac tgtgcggctg tatacggcga tcggcaggcg ttccccccta 443581 tacgcgggag cgtgcgccag aagcattctg tcctttcttc cccgtgaaga aatcgaagca 443641 tacatcaaac aaaccgagct catttcgatt ggctccggaa cgattaccga tcccgaaaaa 443701 ctgcttcagg agattgatgc ctctgtgcaa aatggctata ctgtcagcta ttcagagctc 443761 gaaaactata cggcggcgat cggcgccccg atctttaacc atgagcgcca ggtggcagcc 443821 ggcattagca ttgcaggctt tgaagcgaga tttacagaag acaggctgcc ctatttaaca 443881 gaaaaggtga aggacgccgc tttacagatt tcaagaaaaa taggatatac ataagtagcc 443941 aatcttttct ctgctgcgta cattaacgta tcgacgttca agagtggagg aaagaacatg 444001 gtgcttcgat atacagctct gggcgattcc ttgacgacag ggagaggctc cgggctgttt 444061 tcacccggct tcgtccagcg ttttggggac atgatggaag ctgacttgaa aacaagaacg 444121 gcaataaaca tatttgccag atcaggtctg aatacagaag agattttggg actcctgtca 444181 tatccctatg tgcaaaaatg tattcgagat gctgatatga taacgatcac agggtgcgga 444241 aacgatctca tcgattcggt cttagcctac caaacctcta aggatgaaac gattttcagc 444301 cgtgtatccg cccattgcca tgagaatttt gaaaagatga ttgccaaagt cgccgagatt 444361 aaaggagaaa atccttcccc gtacgccatt cgtgtgttca acttatacaa tccgtttccc 444421 gaaattgata tcgccggcaa atggatcact tcgtttaatt cacatttaga aacacttgca 444481 tcagcacccc atgtcaaaat cgcggatgcc tatagcatct tcaaaggcaa agaacaggaa 444541 tatctgtcct ttgacggtgt ccatccgaac agcaaaggct atcaagcgat ggctgaagcc 444601 gttcacaagc taggctataa agaattatca gtttcataga aaacgcgcct catgacaggc 444661 gcgtttttta tgtgtgatcg aaatattaaa agaaacttaa aattctctgt cttctgttct 444721 acagacaaac aaagtgcgct agaataatgg agggcgtagg caaatatagc cataacgttc 444781 aatatttcgt atataaggaa ggatggtcct tttgtttcgg atttttaaaa tgtcttttgc 444841 ggttatcatt attatactgg cgcttattgc ttttaactat acggaacaca cctctgtaat 444901 ccaatcggtc atgctcgtct ttcttggtgc ggtcatgttt atgcaggggc ttgaagagcg 444961 caaaaaagaa aatgacggct caggcgcttt taatatttat accgccgttt ttgtatggtc 445021 tgtctccctt atcggtttta cacttcatat tatataaatc tattacacat cctgaaaatg 445081 ctcgaccgtc gggaacgggg tatagaaccg atgaagcaag gctttccact cttgatactc 445141 tgaagaaccg cgaaagcctt ccgtatggtc ctcaagtgtt tcccactcca caagaagcag 445201 atatttatgc gtttcctcca tgcattttga taacgagtga gtgatatagc ccttcatgcc 445261 ggaaataatc ggcgcagctt gccggaatgc atcctcaaac tcttgttcaa ggccttcttt 445321 aatgtgaagc attgctgcct ctctgaccat gctatccctt ctttctgtct tttcaaatag 445381 tctacagcaa acgataggag atttctgcaa aatcggtgaa cttttccttc attttcaaaa 445441 aaatcttgca cgcaccaatt caattaagag aaaataacaa gtggaaggca ggggaaagtc 445501 atgttaaaaa agtgtattct actagtattt ctatgcgtcg gattgattgg gttaatcgga 445561 tgctccaaaa cagattcacc agaggatcgc atggaagcat tcgtgaaaca gtggaacgat 445621 cagcaattcg atgacatgta tcaaagcctg actaaagatg tcaaaaaaga aatctccaaa 445681 aaagatttcg tcaacaggta taaagccatc tatgagcagg ccggcgtaaa aaatttgaaa 445741 gtcactgcgg gagaagtaga taaggacgat caagacaaca agacgatgaa acatatcccg 445801 tataaagtca gcatgaacac aaatgccggc aaagtcagct tcaagaatac tgctgtgctg 445861 aaattagaaa aaacagatga cgaggagtca tggaatatag attgggaccc atcgtttatt 445921 ttcaagcagc tggctgacga caaaaccgtg caaattatga gcattgaacc gaaacgaggc 445981 caaatttacg ataaaaatgg aaaaggctta gccgtcaata cagatgttcc ggaaattgga 446041 attgttcccg gagagcttgg cgataaaaaa gagaaagtca taaaagaact cgccaaaaaa 446101 cttgatttga ctgaagacga catcaagaaa aagctggatc aaggctgggt aaaagacgat 446161 tcgtttgtgc cgctcaaaaa ggtcaagcct gaccaggaga aattagtttc tgaagcgacg 446221 tcattacaag gcgtaacaag aacgaatgtc agctcccgct actatccgta tggcgaaaag 446281 acagcccatt tgacaggcta tgtccgcgcc attacagcgg aagaactgaa gaaaaagaaa 446341 gaaggaacgt acagcgatac gtctaacatc ggtatcgccg gacttgaaaa tgtgtatgaa 446401 gacaagctaa gaggcacaac tggctggaaa atctacgtgc cgcaaaccgg ggaagtcatc 446461 gctgaaaaga aagcaaagga cggcgaggat cttcacctca caattgatat caaaacgcaa 446521 atgaagctgt atgatgaact gaaggatgac agcggggcgg cagtcgcgct gcagccgaag 446581 acaggcgaaa cactcgccct tgtcagcgcg ccttcctacg atccaaacgg atttattttc 446641 ggctggagcg ataaggaatg gaaaaagcta aacaaagata aaaacaatcc gttttcagcg 446701 aaattcaata agacatacgc gccaggttct accattaaac cgattgcggc tgctattgga 446761 atcaaaaacg gcacccttaa agccgatgag aagaaaacaa tcaaaggcaa ggagtggcaa 446821 aaagattcaa gctggggcgg ctattcagtg acacgtgtgt ctgagagact tcaacaagtc 446881 gatttggaaa acgcccttat tacgtcagac aatatttatt ttgcccagaa tgcgcttgat 446941 atgggagcgg acacctttac aaaaggcttg aagacattcg gtttttcaga ggacgttccg 447001 tacgaattcc cgatccagaa atcgtctatt gcaaatgaca agcttgattc agacattttg 447061 cttgcggata caggctacgg acaagggcaa atgcaaatgt ctccgcttca cttggcaact 447121 gcttacacgc catttgttga caatggagac cttgtcaaac cgacgctgat caaaaaagat 447181 tcacaaacag ctgatgtttg gcacaagcaa gtggtcacga aggaaggagc ggcagacatt 447241 acaaaaggtc tgaaaggcgt tgtggaagat gagcgcggat cagcgtatca gcctgtcgtg 447301 aaaggaatca cagtggctgg aaaaacagga acagccgagc tgaaaacatc aaaagatgat 447361 aaagacggca cggaaaatgg ctggtttgtc ggctacgatt acgaaaacaa agacctgctt 447421 gtcgccatga tgatccaaaa tgtgcaggac cgcggcggca gccactatgt cgttgagaaa 447481 gcgaaaaagc aatttcaatc gaattaaaat gtctttttaa aaggagcgaa aggaaaaagg 447541 ggatctgagg ccgaatgaac tagtaagggg gcaaaacccg gtttatacaa agaaaagagg 447601 gattttgcat gcagcgtatt caattggcgg aggatcttca attttcaaga gtcatacacg 447661 ggctttggcg gctgaatgaa tggaactatt cagatgctga acttctaagc ctcattgaat 447721 ggtgtatcga tcacggcatc acgacctttg atcatgcgga tatttatgga ggctatacgt 447781 gcgaaaagct gtttggaaac gcccttgccc tttcgcctgg attaagagaa aacatagagt 447841 tggtcacaaa atgcggtatc gttcttgaat cgcctgaacg gcccgctcac agatcgcatc 447901 attataacac aagcaaatcg catattttgg catccgttga gcaatcgctt atgaacctta 447961 ggacggatta tatcgatatg cttttgattc acagaccgga cccgctcatg gatccggagg 448021 gggtagcaga ggcgtttcag gccttgaaat gctctggcaa ggtcaggtac tttggcgttt 448081 caaattttaa agatcaccag tatcggatgc tggaatcata tttgcctgag aagctcgtaa 448141 ccaaccagat tgagctttcc gcatacgaat tagaaaatat gctcgacggc actttgaacc 448201 tgtgccagga aaaacggatt ccgccgatgg cttggtcgcc tctggcaggc ggcaaagtat 448261 tcactgaaaa cacggataaa gaccgacgtg tccgtacggc gcttgaatcc gtccaagggg 448321 aaatcggcgc cgcttcattg gacgaggtga tgtacgcatg gctgtatacg catccggccg 448381 gcatcatgcc gattgtcgga agcggaaagc gcgagcggat ttccgccgcg ataaatgcgt 448441 tgtcatacaa gcttgaccag gatcaatggt tccgcatttt tacagccgta cagggttacg 448501 atattccata aaaagcatca gtttaccagc tgatgctttt tcaatattgt cacaccgctt 448561 agtgccaaat taccatttat aagtgattga ttctttcttg aaagcgtttt atattaaaag 448621 gaaacctctc tatatcctct actgcatctc cttgcgactt catccgcaca tcaagattgg 448681 ctaggaggtc ttttttatgt atatgactgc cagagaacaa aagctgttaa agcacttatt 448741 attacaaaac agatatataa ccgtaactga gcttgctgag ctgatgcaag tcagcacgag 448801 aaccattcac agggaactca aatcaattaa accgctgatg gaaaccgtgg ggcttacgtt 448861 agataaacag cccggtaaag ggttgaaagc agtgggaagt cccgagggta aacaaaagct 448921 gcttactgat ttatcatatg aacagcatga atacagcgcc gacgaacgga aactgctcat 448981 tctttgttcg ttattagagt ctcaggagcc cgtcaaactg tacacgcttg ctcatgatct 449041 ccaggtgacg aatgccacgg tcagctatga cttagatgag ctcgagaagt ggatttctcc 449101 ctttggactg acactgatcc gcaaaagagg ttttggcatc cagctcatag ggccggagaa 449161 tgcgaaacgg aaaattgtcg gcaacttgat tgtgaaccgt ctcgacatcc aaatgttttt 449221 ggaagcggtt gaattaaaca tcaaaggaaa aaccgattct tcagagaaaa tgttcggggt 449281 tgtcagcaaa ggtgagctgt taaaaatgga gcgcatctta tttcagctca aagaaaaaat 449341 cgctttttca ttgtccgaca gctcctatat agcgctcgtc gtccatctga cgtatgcgat 449401 cgaacgaatt aagcttgggg aaactatcac catggagcaa aatgagcttg aggaactgat 449461 gaatgcgaag gaatacagct ccgctcttga aatcgcgggc gagcttgaac gtgccttcgg 449521 cgtgacgatt ccagaggcgg aggtcggcta tattacaatc catcttcgaa gcgccaatcg 449581 aaaatacaaa acagaataca aagcgcagga aattgagctg gaaacagccc tgcaaacaaa 449641 gcggctcatt gcttttattt cagacaaaat cagaatggat ctgacgaaaa actactcttt 449701 atatgaaggc ttgattgccc atttggagcc ggccgtcagc cgcataaaag aaaatattga 449761 gatatacaat ccgatgaagg aacagatcaa gcgcgattat tttctgcttt atatggcgat 449821 cgaagaaggt gtcgaaaagt attttccggg catgtccttt tctgatgatg aaatcgcttt 449881 tatcgttctt cactttggct cggctcttga aatcaaaaaa gaagaagcaa aagtgaaagc 449941 gcttgtcgtc tgctcaagcg ggatcggctc ctcgaaaatg cttgcctcca gactgaaaaa 450001 agagctgccg gaaattgaat cgtttgatat gtcatctctg atcgagctaa aggggaagga 450061 tgttcaagcc tatgatatga ttgtgtccac tgtaccgatt ccttatgaaa acattgatta 450121 catcatggtc agcccactat taaatgagga agacgcaaac caggtcaagc agtatatcaa 450181 gcggaagatt ccccttattc ttaacaaaaa aagaagctcg aaggaagagg cgcagcaagc 450241 tgatgtacct gacatgctgg aggcggcgga aagcataggg cggtatatgg aagttatcca 450301 agatgttctg cgccatttta cgctagctca actcaaaaca aacccggacc atagcatgct 450361 tctgctagag ctttttcaac agctgaagaa ggatggcctg atccgtgatc cggaaaaagc 450421 cgcggtttgc ctggctgagc gggagaaaca agggggattg ggaatccccg gaacaaacat 450481 ggcgctttat catctcaaaa atgatgaaat cgtcctgcct tttttcaaaa tgtttgatct 450541 cagcaccccc tatgaagtgg atggcatgga cggaaatacc ctcaggatga cacgcattct 450601 cgtcatgatg gcgcctggct cattatctgc tgaaggctcg gagattttaa gcgcgatcag 450661 ctcggcaatt atcgagagcg gagaaagcat ggcggggttt caggaagaag gaggacaaga 450721 attgtatcag cggttaaacc gcatattttt cacatggatg aaagaaaaaa acatactgta 450781 aacctgcatg gcacacgtca aaaatttggc gtgtgttttt ctgtggatgg ggaacaaaat 450841 aagaaaatgt gggactattt tatcattcag tattggaata attccaaaat gaaatagttt 450901 tacaagttat cttttttggg ttaaaatggg tgaggtaagg aagaaaatct aacaaattat 450961 tgaagattca agagaatata ggagatgacg atatggaaac attacagcat ctgattctgc 451021 atgacatgcc gaatagcgaa gaaatagagg ctgtaaaaag cggagaccat acactgacat 451081 ataaaggtta ccgtaaacgg attaatcagc tggcgaatgc catgcttcaa aaaggaattc 451141 aaaagggcga ccgtgttgca ttgctttgca aaaacggcca tcccgcctca actgttatgt 451201 tcgccgcact tgaaataggt gctgttgtcg tacctgtcag ctggcagctg aaaccatatg 451261 aaatgacagg cattttaaaa gcaagtgaac caaaagcgat gttttacgga gcggagttta 451321 aagagatact ggatgaagtt cttcctgaat tgtcctcact gtgtgtaaca atggaaacag 451381 gaacagctta cgaaacatct gctgaatttg aagcgctgtt tgcaggtcct gatcatttgc 451441 cagagacgga aatggtttca cctgatgata cagcacttct gatgtttaca tctggaacaa 451501 cgggaaaccc gaaaagatgc atgattacac atggcggcat atacagatac gttaaaaaat 451561 ccaacagctc aatagcacgt atgaagggcc ttcgttttct cgcgtgccat ccgatttatc 451621 atacgagtgc gctcatttgc atcatgcttg gaacgtttgc agaaacaaca tttgtgttta 451681 caaaggatca agatcctgtt cacatgctga aggtcattga agaagagaag attcagaccg 451741 tgatggctct tcctgtgttc tacacgtatt tgcttgaggc gtgggaaaag caccaaactg 451801 acttatcttc gcttgttatt ttaatgacag gcggaacaaa agtgccgagc agcctaataa 451861 gccgctatct tgatattggc attccgcttg cgcatggcta tggaagtact gaggcttggg 451921 gcatcagcac atggacgcct gatatgggaa tggataaagc ggcatctgca ggaaaacctg 451981 tggcaggtgt taaagtcaaa gtggaagatc ctctgaccgg agaagaactt cctcaaggag 452041 aaatcggcga aatcgttgtt catactccat tcttatttaa aggctatgaa gacaatcctg 452101 aagcaacagc gaaagtgctg caaaatggat ggtttagaac cggagattca ggatatgtag 452161 atgaagatgg ctttattttc atcacgggac gctacaagga tgtcattatt tacggaggcg 452221 ataacgtcta tcctgatcag gttgaagaag ttatccagca gatcccggga atccttgaaa 452281 cggctgtggt cggtattcct gacccgcttt acggtgaaaa accgaaagct tttatcgtga 452341 aaaatggcgg ccagcgcatc acggaagagg atgtcatcgc attttgtaaa gaacgcctgt 452401 ccgcttacaa aatacctgaa gttgaatttg ttaacgaact gccgaaaaac aaccttggca 452461 aggtgaaaaa agacgtcctg cgcaatcagg ctgtacattc ataaaagaag aagcccgtcc 452521 actttatgtg gcgggcttct ttgcagttgc acagacggaa agctcaggct taatgttctt 452581 aaattgtata tcaatgtctt cgaagccggc tgctttaaag tcagcaatca tctgtcttcc 452641 aaatgatttg gttttctcag gactggcatc cgcttcccgc ggctgcatcg taatggctgc 452701 tttgccgcct ggctttaatg cccgataaat ctgttttatg ccttttgttt ggtcattcca 452761 aatggtgtag ttgttaacgg aaatcacttt atcataaaac gaggcgggga gaggaaatgt 452821 ctcgatgctt ccttgtatca ggcgtacgcc ctttggtttc actctgcggg cggccagctt 452881 cagcatggcc tctgatacat caatcccatg aagatgaaca tccttctcgc gtttcagcat 452941 ctgctgcatg cagtatcccg ggccaaaccc gacttctaaa atgctgtccc cgcgcgtgat 453001 acccagctga ttgattgtcc actgattcag tgtttgattt tcagcagcca tgatgtaccc 453061 ggcaatcatg ccgatgacgc cctttggcct gctgaatctt ctagaaagca tgttaatcat 453121 tcagcaacca accccctttt tgagttaatt tcctctcagc gttccatgtg aaacattttt 453181 ctgataaagc aatgcgaagg tgccaagcca tgtttatcca aagagtgtgt gaggtacaca 453241 acaaatagac atgaaaacaa aggaggagaa tcatcatggc aaattatcca aaagaactgc 453301 cggcacaaac tcaaagtcgc cagccgggaa ttgaaagcga aatgaatcca agtccggtgt 453361 atgagtacga ggattataaa ggagcagaca aattaaaagg aaaagtagct cttattacag 453421 gcggcgacag cgggatcgga cgcgcggttt ccgtcgctta cgcaaaggaa ggcgcagaca 453481 tcgccattgt gtataaggat gagcatgaag acgctgagga gacgaagaaa cgtgttgaac 453541 aagaaggcgt aaaatgcctg ctgattgctg gtgacgtagg tgaagaggaa ttctgcaatg 453601 aagcggttga aaaaacggtc aaggaactag gcggccttga catccttgtc aacaatgcag 453661 gtgaacagca cccgaaggaa agcatcaaag atattacgag cgaacagctt caccgcacat 453721 tcaaaacaaa tttttattct caattttatt tgactaaaaa agcaattgat tacctgaaac 453781 cgggcagcgc catcatcaat acgacatcca tcaacccgta cgtagggaac ccgacactga 453841 ttgattatac agcgacaaaa ggggcgatca atgcctttac aagaacaatg gcgcaggcgc 453901 ttgtcaaaga cggcatccgt gtaaatgcag tcgcgccggg tccaatttgg acgccactaa 453961 tcccagctac gttccctgaa gaaacagttg ctcaatttgg gcaagatacg ccgatgggcc 454021 gtcctggaca gcctgttgag cacgtcggct gttatgtgct tctggcatca gatgagtcct 454081 cttacatgac aggtcagacc ctgcatgtca acggcggaaa ctttgtgacg acataagagg 454141 gagtgagaca tatgggcatc acgaaagaag aagtgaacag ctactatcaa aaagcaggga 454201 ttgtattaac ggacgaggaa gtagaccaaa tccagctgat ggattacggc ttaggaaaag 454261 aaagaaaagt cgggctccag ctcttcgtct acgtcaatac agaccgttat tgttcaaagg 454321 aattggtgct gtttccggga cagacttgcc cggaacaccg ccatccaccg gtcgacggcc 454381 aggaaggcaa gcaggagacc ttccgctgcc gctacggaaa agtgtatctt tacgtagaag 454441 gagaaaaaac gccgcttcca aaagttctcc ctcctcagga agacagagaa cactatacgg 454501 tctggcacga aattgagcta gaaccgggcg ggcaatacac gattccacca aacacaaagc 454561 attggttcca ggccggggaa gaaggtgccg tcgtgacgga aatgtcatcg acgagcacgg 454621 ataaacatga tatctttacc gatccaagaa tataaggatg ggcttaacag cccatccttt 454681 ttgtattgaa aaaaacagaa tcatcgctat aatgggtaaa aaaggaaaga gggcgaggca 454741 atgttcactt gcaaggtaaa tgagcacatc accatccgat tattggagcc gaaggatgcg 454801 gagcggctgg ccgaactcat tatccaaaat cagcagcggc ttggcaagtg gctgtttttt 454861 gcggaaaatc caagcagcgc tgacacgtac cgagaaacaa tcattccaga ttggcggcgc 454921 cagtatgccg acctgaacgg cattgaggcg ggtctccttt atgacggcag cctatgcggc 454981 atgatcagcc tgcataacct tgatcaagtg aatcgtaagg cggaaatcgg atattggatt 455041 gccaaagaat ttgaagggaa aggcattatt acagctgcct gccgaaaact cattacgtat 455101 gcttttgaag agcttgagct gaatcgtgtg gcgatctgtg cggctgtcgg aaacgaaaaa 455161 agcagagcgg ttccggagcg gatcgggttt ctagaggaag gaaaggcacg ggatggctta 455221 tacgtaaacg gcatgcatca cgacctcgtc tactacagtc tgttaaagcg tgaatgggaa 455281 ggcgaaaaat aaagagcaca ctttcttgtt taaatcttcc ccggatgtgg aaaagtaaca 455341 gcggagacgt taaaaaggag tgattcgaga tgaatcagca agacattaaa caaaaagtgc 455401 ttgatgttct agatcaccat aaagtaggtt cgctcgcaac agttcaaaag ggcaaaccgc 455461 attcccgcta catgactttt ttccatgacg ggctgacgat ttacacaccg acaagcaagg 455521 aaactcataa agcggaagaa attgagaaca accccaatgt ccacatttta ttaggctatg 455581 attgtgaagg ttttggcgac gcatatgtcg aagttgccgg aaaagcaaag atcaacaatt 455641 cggcagaact caaggacaaa atatggagtt ccaaattaga gcgctggttt gacggcaagg 455701 atgatccgaa tctggtgatt cttgaaattg aaccggagga tatcagatta atgaatgccg 455761 gggagaaaac accggtctca ctcgaactat aaaaaatttg tgttttcagg ggcgatatgt 455821 tattatgaat agctagtaag aaaaataagc aaataaaaaa gaaagtaaac ttcttttttc 455881 tgttttgaga gagaagctta ccgcttccca agcagcataa ccagctgccc ttattctttt 455941 ccttcataac aaatcgcccc taacgatgag atggaaaaaa gacttttttg ttttacaatt 456001 cacaccggcg cggcttcgga gccgcagtga cgattgagag gtagggcttt cgttgtcttg 456061 tgttcaagaa atttccatgg tgtttacttt ccagaatgat tcttcggaac aatgctttat 456121 gaatctaacc cgcctgactt ggcggatgat ataatcttta tttgcgtata gaaaagaata 456181 agacaaaccg cccggcgtac gccggacggt ttttttattg caaaaaacac atcgtactga 456241 aacctccttg tcttctttcc agtcttatct ctaggatgaa attggaggaa gaataacgtg 456301 catgtcatta caacacaagt actttttatt ttttgttttt tattgctgat tcactcgata 456361 gaaaccttag cctatgcgac aaggctttcc ggagctcgcg ttggatttat tgcgtccgcg 456421 ctttctctgt ttaatgtcat ggtcatcgta tccagaatgt cgaatatggt gcagcagccc 456481 tttactgggc atttaattga tgatgctgga aaaaacgcac tggcgattgt aggggagcag 456541 ttccgctttt taattttcgg atcgacagtc ggcaccattt tgggcattat cctgctcccg 456601 tcttttgtcg ctcttttttc acgggcgatt attcacttgg cgggcggcgg cggctccgtt 456661 tttcaagtat tccgaaaggg attctcgaaa caaggattca aaaatgccct ttcctatttg 456721 cgtctgccgt ccatttcata tgtaaaagga tttcatatgc gcttgattcc gaagcgtttg 456781 tttgtcatca acatgctgat cacatcgatt tatacgattg gtgtgctttc ggctttatac 456841 gcaggccttt tggcgccgga gcgcagcacg acagccgtca tggcttcggg tttgatcaac 456901 ggaattgcaa cgatgctgct ggctattttt gttgatccta aggtatccgt tcttgctgat 456961 gatgtggcaa aaggaaaacg aagctatatc tatttaaaat ggacctctgt cacaatggtc 457021 acatcaaggg tggcgggcac actcctcgcc cagctcatgt ttattcccgg ggcctactat 457081 atcgcgtggc tgacaaagtg gttttaataa gaaaggctgg atcataaaga tccagccttt 457141 ttgcgcttcc ttatttatag ttccttaatc cgcggtcgta caaaaaattt ccgaatggga 457201 cgaaagcggc gatgaagccg gcagctgacc atttcagcgg ccatttgaca gagaaggttg 457261 cataagccaa gacaagcaaa tacaaaatga acaacccgcc gtgaaccgaa ccgacaattg 457321 tcaccgcaag cggaaggcct gcccaatatt taagcggcat agcgatgaac aacaggatta 457381 agagtgacat tccttcaata aaacccatcg tgcgaagtct tccgatcggc gtgtgcagca 457441 taaatcgccc tccttgtgga cacgttttca ttttatacta taaacaatcc gggggggcat 457501 atgacagctt tcaaaaaatg ttcggaaaac attcattttt acatgccttt tctagggaac 457561 tgtacttgtc atttacaaaa atacccgaga taatgtgtac aaaatcaaaa aagaaggatg 457621 ttgaaatgaa acttgaccag attgatctga atatcattga ggagctgaag aaggacagcc 457681 gtttgtcgat gagggaatta ggcagaaaaa ttaagctgtc gcctccatct gtaacagaac 457741 gggtaagaca gcttgaatcg tttggcatca tcaagcaata cacgctggag gtcgaccaga 457801 aaaaactggg gcttcccgtt tcctgcattg tggaagcaac cgttaaaaac gcggattatg 457861 agcggttcaa aagctatatt caaacattgc cgaatattga attttgctac cggattgcgg 457921 gtgcagcctg ctatatgctg aaaatcaatg ccgaaagcct cgaagcggta gaagatttca 457981 ttaacaaaac atcgccctac gcgcaaaccg tcactcacgt cattttctca gaaattgaca 458041 cgaaaaacgg gcgcggttag agagtgccgc gcgaagtctg ttataataac aggatgagcg 458101 tgaaagaaag agaagtgatc aagcatgtca aaaacagttg tattagctga aaaaccttca 458161 gtcggccggg atttagcccg ggtactgaag tgccataaaa aaggaaacgg ttatctcgaa 458221 ggcgatcaat atattgtgac ttgggcttta ggccatttgg tgacgcttgc tgatccggaa 458281 ggctacggaa aagaatttca atcatggcgc ctagaggatc tgccgattat cccagaaccc 458341 ttgaagcttg tggtgataaa aaaaaccgga aagcagttca atgcagtcaa atcccagctt 458401 acccgtaaag acgtcaatca gattgtcatc gcgactgacg caggccggga aggtgagctt 458461 gttgcgcgct ggatcattga gaaagcgaat gtccgaaaac caatcaagcg gctgtggatt 458521 tcatctgtga cggataaagc gatcaaggaa ggttttcaaa agctgcgcag cggcaaagaa 458581 tatgaaaacc tgtaccattc tgccgtcgcc agagcggaag cggattggat tgtggggatc 458641 aacgccaccc gtgcacttac cacaaaattc aatgcccagc tctcatgcgg gcgtgtgcag 458701 actccgacgc ttgccatgat tgcaaagcgc gaggcagaca ttcaggcgtt tacgcccgtt 458761 ccgtattacg gcatacgtgc tgcagtcgac ggcatgacgc tgacgtggca ggataagaaa 458821 tcaaagcaga cgagaacgtt caatcaagat gtaacaagcc gtttgctaaa aaatctccaa 458881 ggaaagcaag cggtcgtagc tgagctgaaa aaaacagcga aaaaaagctt tgcgcctgcg 458941 ctttatgatt taacggagct ccagcgtgac gcccacaagc gcttcggttt ttctgccaaa 459001 gaaacgcttt ctgtcctgca gaagctatat gagcagcata agctcgtcac atatccgcgg 459061 acggactcta gatttttatc cagtgacatc gtcccgacgt taaaagaccg tctggaaggc 459121 atggaagtaa aaccgtatgc ccaatatgtc agccaaatta aaaaacgcgg cattaaatct 459181 cataaaggat atgtcaatga cgcgaaggtg tcagaccacc acgcgattat cccgaccgaa 459241 gagccgctcg ttctcagcag tctgagtgat aaagaacgaa agctgtatga cctgattgcg 459301 aaacgtttcc tggctgtatt aatgcctgca ttcgaatatg aggaaacaaa ggtcatcgca 459361 gaaatcggcg gagaaacctt tacggcgaaa ggcaaaaccg tgcagtcgca agggtggaaa 459421 gccgtttatg atatggcgga agaggatgat gagcaggagg atgacagaga tcagacactt 459481 cctgcgcttc aaaaaggcga cacacttgcc gtccgcacgt taacggaaac aagcggccaa 459541 acgaagccgc ctgcccgctt taatgaaggg accttgctgt cagcgatgga aaacccaagc 459601 gcgtttatgc agggagaaga aaaaggcctc gtcaaaacgc ttggagaaac aggcggcctc 459661 ggcacggtgg caacgcgtgc cgacattatt gaaaaactgt tcaacagctt tttaatcgag 459721 aaaaaaggcc aagatatttt tatcacatct aaaggaaaac agctcctgca gcttgttccg 459781 gaggatctga aatcaccggc cttaacagca gaatgggagc aaaagctgtc tgcgatcgcg 459841 gccggcaaat tgaaatcggc tgtttttatt aaagatatga aggcttacgc tcaccaaacg 459901 gtaaaagaaa tcaaaaacag cagccaaacc ttccgacatg acaacattac gggaacggca 459961 tgtccggaat gcggcaaaat gatgctgaaa gtaaacggca aacgcgggac gatgctcgtg 460021 tgccaagatc gtgaatgcgg aagcagaaaa acgattgccc gaaaaacaaa cgcacgctgc 460081 ccaaattgcc ataaaagaat ggagcttcgc ggccaaggcg agggccaaac ctttgcgtgt 460141 gtgtgcggtc accgtgaaaa gctctctgta tttgaaaaac gaaaaaacaa agacaaagcg 460201 cgtgctacca aacgggacgt atcctcttat atgaaaaaac aaaataaaga tgagccgatt 460261 aacaacgcgc tggcagaaca gctgaaaaaa ctcggtttgg ataaataata aaaaaacctg 460321 tgcctatcgc acaggttttt tattggactt aggtcctgtt ttcttaatgt tcaaaaaggg 460381 aaaaaaaagc tagcaatctg catttttttt cttttatagt aaatgtactt tgtaacatgg 460441 cagtcatatt ttcgtctata actatttgtg agcgtctgat ttgcttcagg cgacaaaggg 460501 ggatttgcct gtgaggcatg tactaattgc tgtcatctta ttcttcttat ctatcggact 460561 ttccgcaggg tgtgctgaag ctggaaacaa gacccaaaat cagtcggcga cagaagtgaa 460621 tgccagcccg ctccagccgg cggaatattt catctatcac aatttaatga atgacaaagg 460681 gctgatcaaa accgattttt cagaccagcc ttcttacttg tcggaatctc tcggactgtg 460741 gatggagttt ctgctcagca aaaatgacgc accacatttc caggatcaat atcagcatct 460801 gactgattca tttctgatga gcaatcactt ggtgacgtgg aagattcaaa atggccaagc 460861 gagcgggacg aatgcgctga tagatgatat gagaattatg ctgtctcttg accaagccgc 460921 cgcaaaatgg ggccgcagcg actacgcgca aacggctagg gatatcggca cgtctttgaa 460981 gacatacaat atgaacaacg ggttttttac agacttttac gactcacagg ccgcttcaaa 461041 ggatgtgacg ctttcatacg tcatgcctga tgccttagct gtcttaaaga agaatggaat 461101 catagacgaa gaaacagaac agcggaatgc caatgttctc tattcagctc ctttaaaaaa 461161 tggctttctg ccgaagacat acagctcgga gacgaaggaa tacacatatg atagtgaaat 461221 caacctgatt gatcagcttt acgctgcttg gcatttgccg gaaggggatg aaaaagcatc 461281 tgttttagcg gactggatca agcaggaatt tcagaaaaac ggaaagctgt acgggcggta 461341 ttcggcatat acgaaggagc ctgccgtcca atatgagtct ccatccgtat atgccttagc 461401 cgtattgttt ttgacaaaac agcatgaaaa cagttctgtc atcaaagcca tatatgatag 461461 aatgaatgac tttgaaattc atgatccggt gaaatcgtat tatggaggct atatgagcgg 461521 cactcagacg cattcatttg acaatctgct gccgctgtta gccgaaagga agctttttaa 461581 tgaaaatatc attcagtgaa tcacaaaaat tatttgctta tttttcaggg ctcatcgcgg 461641 ccctgtcttt gtttatttat tatgtgtcag cccagcaatc agaaggtgct ctgatccttt 461701 gcatcacatt tggcgtcatc gccgcaggca tctggttcgg cccgatttac gcgctggcag 461761 tgaccttaat cgtactcttt gttctcggca ccttaatgat gtttttccag actggacaga 461821 catcgctctt tccggctgag gaagggctgc gaatgcttgt cgtgtgggga atcgcgcttt 461881 tgctgttttc ttttatttct ggaagaatcc acgatattac agcagagctt cggcgctcaa 461941 tgacacggct tcaatccgaa attaaaagct atgttgctgt tgacagagtg actggttttg 462001 ataacaagca aaggatgaag ctggaacttt cagaagaaat caagcgggcg gagcgctacg 462061 gcaattcttt tgtgtttttg ctgctccata tgcattattt caaagagttt aagtctttgt 462121 acggtgaaaa agaaacggac cgcctcttcc aatatgtcgg tcagcaaatc aggacaagcg 462181 ttcgggaaac ggataagaaa ttccgtccct ctgacgagcg tatcgggatc gtgctgacgc 462241 acacgcctgc tgaacatatg ccggccgttc tgactaagct gaagaaacaa ttggatacat 462301 atcagctgga aaatggaaag tatgtgtcgc ttacgttcca cgtttgctat ttgccctacc 462361 gcaacgatat ccaaacagct gatcaatttt tagaagaact ggaaaacgag atgatgatga 462421 atgaactata aaggaatcac attgctatgc gtcatgatgc ttctattttc agctattgcg 462481 tcttttcccg tttctgcgca agcgaaagat caggatgccg gcattctcat catctactca 462541 accttggacg gcaaagagtc gtcacaagtc aaaatgctcg atttgcttgc gggccacttt 462601 acatcccatg tgacagtcaa aaaagattca gacgttgaag cgtcggattt caaagggaaa 462661 gaccatgtga tttattacgg ccaaacgaaa agaaagctca gccaaaaatt gctgtctctt 462721 atcagcggcg tgaaaaaacc ggttgtcgcc attggctata acgcaggcca aatcagccaa 462781 ttttctgggc tttcattagc ccgcaaagaa aatgtgtttc aggttcacag caggtcagaa 462841 aaggccgatg tgtctctgga aagcgggctt aacgtgctga gtgtatcagg cctgaaagga 462901 acggcgcttt acaccttcaa agcggatgaa ggcacaacgc attcttttat atggaaaaca 462961 aaaaaaggga atgtgtacat tggattaaca aatttgttaa atgacaattt gatcgtggcg 463021 aaacagctca gagaagcttt cggagagaag gcggggacga cgttattgta tttgcgtctc 463081 gaggatatca gcccgatgtc tgatgaaaaa ctgctgcttc aagccggtac atacctgcat 463141 aagcggcata ttccttttat cctggcggtc attccggttt acttgaatcc ggaaacaggc 463201 gacaaagtgt atttgtctaa tcaaccgaag atggtcaagg tgctgaagaa gctgcaaagc 463261 atgggcggca gtatcatagt tcacggctat actcacgctt atcgctacag tgaaacagga 463321 gagggatttg aattttggga tgcaaaggcg gatcagccga ttacatccgg aaatgccgaa 463381 gaccccccgt ccattttgga gaaagaacag gacttcccga acgaacaagc ctatcacagc 463441 tatcttgaac catttcggga aaaggaagaa acgtatacaa aacaaaaact gacgcgtgcc 463501 attgaggatt tgacatcatc gggtctttac ccgctggcgt ttgaagcgcc gcattacacg 463561 atgtccgaat atggctatca aatcgcctcg cagtatttta caagcatttt cggccaggtc 463621 cagctcagca gcacaacatg gaaaacatcc ggtgcacctc cgtttgtgac tgctccttcg 463681 atgctgcacg gaatgacgct ttatccggaa acgatcggct ttgtcgacac atcgaagcaa 463741 aacccgctcg gtgagatgga ggagcatatc tcccagatga ttgattttga aggcggagta 463801 gccggaggat tttatcaccc gtaccttggg atgaaatatc tgcctgagct ggttgatcag 463861 atggaacgca ttccagacag tgaatggctt gatttaaaga aaacgaaaca aaccgtcaaa 463921 acagacaaag tggaaattca tacaagcggt gacggaacga ttcaggtgaa aaacggcgta 463981 agccccattt acgagttttt cgatcatcac cggcaaaccc ctctggaaaa ggcgttatgg 464041 attctctccg ctgttgtgct cttatttgtc atcatgtttg tcagttatac gttttacttg 464101 agagccacat tgaaaaaacg aatttttaag gagagaagaa gccttgggta atacgctgtt 464161 ctttatctcg ctaagtttaa tatgggttat gcttctctac cacatgttcc tcatgcaggg 464221 cgggtttcgc cactatatga ccttcgaacg gaatatcccg aagtggagag aaaatatgaa 464281 ggaactgccg aaggtcagcg tcctcatccc ggcgcataac gaagaggttg tgattcggca 464341 gacgctgaag gccatggtca acctttatta tccgaaggac cggctggaga ttatcgtcgt 464401 taatgataat tcatcagacc ggacgggtga tatcgtcaat gaattttccg agaaatacga 464461 tttcatcaaa atggtgatta cgaagccgcc aaatgcagga aaaggaaaat cctctgcact 464521 taactcgggt tttgccgaat cgaacggcga tgtgatctgt gtgtatgacg ccgacaacac 464581 gcctgagaaa atggccgtgt attacctcgt gctcggcctg atgaatgacg aaaaggcagg 464641 cgccgtggta gggaaattcc gcgtcatcaa tgcggcaaag acgctgctga cgaggtttat 464701 taatatcgaa acgatctgtt ttcagtggat ggcccaggga ggcagatgga agtggttcaa 464761 aatcgccacg atcccaggca ccaacttcgc gatccgcaga agcattatcg aaaagctcgg 464821 aggctgggat gacaaagcgc tcgctgagga tactgagctg accatccggg tatataatct 464881 cggctatcac atccgctttt tccctgccgc catcacgtgg gagcaggaac cggaaacatg 464941 gaaggtatgg tggcgccagc gcacccgatg ggcgcgcggc aatcaatatg tcgtgctcaa 465001 atttttggcg cagtttttta agctgaaacg aaaacggatt atctttgatt tgttttattt 465061 tttctttacg tacttcctgt ttttctttgg cgtgatcatg tcaaatgcga tttttgtagt 465121 gaatttgttt tatgatttgc atttgtctgt tggatttttg gcaatgattc tctggatttt 465181 ggcgtttttc ttatttatga cagaggtcat gattacgttg agcattgaaa aaacagaaat 465241 gaacaagcaa aactttttta tcgtatttct catgtacttc acatactcgc aggcatggat 465301 tgtgcttgtt atctactctt tattcgtaga aatcaagcac cgtttattca agcaagaggt 465361 caaatggtac aagacagaac gatacaatca acataaaagc gggtgacctt tttgaaacaa 465421 ataatgattt ttctcacaag cttcatgctg ctggcgatga ctggacaaac ggctcttgcc 465481 aaagacgtac aggtcagcgg ttcgctcctt gggaaaagca gccaagaaca agccaaacag 465541 caggtgctga caagcgagct gattacactg tatggatcaa aagacagcgc agagctgacg 465601 tatcagatcc cggcaggcgc ctcttcgggc aatcagcaat tggtaatcga atacgaggca 465661 tcaaatcttt taatttctcc atcatcgtta acggttgtca ttgatgatga accggtcaag 465721 acgttaaagc ttgatggtga ttccaaacgg aaaacagtga agctgaatct gaataaaagc 465781 cagtctgcgc aaggctatca caacgtatcg ctgaaattct acggcgtaat gaaagagggc 465841 gtgtgcgtca gacaggatac atcaggcaac tggatcaaaa tttatccgga cagccggctg 465901 acacttgctg acagcagtga agcgaaggga acgtcgctgg accattatcc gtatcctttc 465961 gcccaatctg gaaatacagc ggaagaaaca gctatcgtca ttccggataa cccaagttca 466021 gcagaaatag aagctgctgt taaaacagaa ggctatttga aaacggtgga cagcagtgtc 466081 agtattgcgt atgtcacgga atctgaactg aaaaaaatcg ataagccgac gattgttatc 466141 ggcgtggaca agcattggaa cggcaaagtg aaaaaactgt tgaaacaagc cgggctacag 466201 gcaaaaggag aaaaccttct gcttgcggag cgggtgctga aagcagaggg caaacagcag 466261 ccggttctgt ttgcgcaagc ggcgtccgag gacgcgctca caaaaaaaat cagcgtgatg 466321 acagatcaga catatacagg ccagctcagc ggcgatacac tttcaatcag caagcttcag 466381 cagactgaaa aaaaagaaag cgataagctg acccttgaga attttggagc gggtgatatc 466441 acaattggag ccgacaaaac atcttcagca cattattttt atccggcttc ggctgtttta 466501 gatgaaaacc aatcggcgaa gctgtcgctt aaactgaaaa agtctgaaac gattcaagcc 466561 tcaacggctg aaaacgagtc agcctctcag gctgcagaac tgaaagtgat gatcaacggc 466621 cagccgcact cggtccggct tgatgaatta ggaaaagaag ataaaaacgg attctatcat 466681 gtcacagtga aagtggaccc taagctgctg caaaaaaacc gctacattga tattcagttc 466741 gtcacgaccg gtttaaagga aaacaaccct tgtaacacca ctgatgaaga aaagtgggtt 466801 tttatcgata aaaacagtac attatcatac gccatcaaag gcatgtcccc gtcagcggat 466861 tttcaagagt ggccgctgcc ttacgccgga aaccaggatc aaacaacgtt aatcgtgctt 466921 cctgacaccg taagccaatc gaagctagag gagctttctc tcgtaacaga atcctttggc 466981 aacgaagcac agcattcata tacggtaaag aaatcatctg acgttacagc aaatgatgcg 467041 aaaggacgaa acctcatttt cataggaggg atcaatcaat tttctcttct gaaggagaaa 467101 tcatcagatc tgcttgtgcc gcaggaaaag aacggctcgt ttgatgtatc tagtttcgag 467161 atgctgaatg agacgacaaa acaagtggta tttacccaag catcggtttg ggattcacgc 467221 tatacaatgg ctgtctttgc accgtcaaaa ggagatggca cggctgtcac aaaagagatc 467281 atcagttatc tgaacagcaa cgatgagtcg gcaaccgtcc ttaatgaaac aaacagccag 467341 caggtgttta caaaccacca gcagctcaaa tcggaaacaa acagttccga tgcagaacaa 467401 ccaacacagg atcatagcca gaaatggatg tatattggtg tgctggcact cattatggtg 467461 gttgcggcag tgttcatttg gattgccgta agacgcaaaa aaagaaagac agatacagaa 467521 taaaacagag gcgattttag cctctgtttt tttatttttg gtaagtaaat tccatttgtg 467581 gaacctgtca ttttattttt ttctctcagc caataagcct ctttacaacg tgcgggaacg 467641 ggagtatgat ctcttttaga aaacaaatcg cttaatctga aatcagagcg ggggacccaa 467701 tagaacggct ttttgccgtt ggggtgaatc ctttttaggt agggctaact ctcatatgcc 467761 cgaatccgtc agctaacctc gtaagcgttc gtgagaggag atgaatgaaa cctgtgttcg 467821 atgttatggc acaggggcat ccgtttgcct ctgtgttttt tgttgttcat ttttgaatgc 467881 aaatcgcata cagagacatc atagcagaaa ggactatcat caacatgtga gagcaagaca 467941 ctgatggatg ttttattgtt ttaattgaaa aatgagaaat taaaagggga agacatcgat 468001 gtatcattca atcaaacgtt ttttgattgg gaaaccacta aaatcccaag cagctggaga 468061 gcaaaaactg acgaaattaa aagccttggc tatgctttcc tcagatgcgc tgtcatctgt 468121 cgcatatggg acagaacaaa ttctaatcat tttggcaaca atcagtgcag ccgcattttg 468181 gtactccatt ccgattgcgg ttggcgttct catcttgctg ctcgcactga ttctttcata 468241 caggcaaatt atttacgctt atccgcaggg cggcggggcg tatatcgttt ctaaagaaaa 468301 tctcggtgaa aaaccgggat tgattgcggg cggttcattg cttgttgatt atattttaac 468361 agtagcggta agtatttccg caggcacgga tgccatcacg tcagcctttc ctgcattgca 468421 tgattatcat gtgccgatcg ctatttttct cgtgttagtg attatgattt tgaacctgcg 468481 cgggctttcg gaatcagcat ccatacttgc ctacccggtt tatctgtttg tggtggcgct 468541 tttggttctc attgcagtcg ggttgtttaa acttatgaca ggacaaatag accagccagc 468601 ccatcataca tcgctcggca cacctgtagc cggcattacg ctatttttgc tgcttaaggc 468661 tttttcctcc ggatgctcag cgttgaccgg ggttgaggcc atttctaatg cgattcctgc 468721 attcaaaaac ccgcctgcgc gaaacgcggc aagaacgctt gcgatgatgg ggattttgct 468781 ggcgattctg ttttccggca tcacggttct cgcgtacggg tatggtacgg cgccgaaacc 468841 tgatgaaaca gtggtttcac aaattgcgtc cgaaaccttt gggcggaatg tgttctacta 468901 tgtcatccaa ggtgtcacat cgcttatttt ggttcttgcg gcaaatacgg gattctcagc 468961 cttcccgcag cttgccttca acctggcgag agaccagtat atgccgcgaa tgtttacagt 469021 caggggcgac cgcttaggct tctcaaatgg gattatcttt ttaggctttg cctccattgt 469081 tctcattatc ttattcgggg gacagacgga gcacttaatc ccgttatatg ctgtgggcgt 469141 atttattcca tttacgcttt cacaaaccgg catgtgcatg aaatggatca agcaaaaacc 469201 aaaaggctgg atcggaaaaa tgctgatcaa ctcctgcggc gctctgatat catttatggt 469261 tctatccatt ctgtttgtga cgaagtttaa tgtcgtatgg cctgtgttaa tctttatgcc 469321 tatcgtcgtt ttgctgtttt ttgcgattaa aaatcactat actgcggttg gtgaacagct 469381 tcgcatcgta gacaaagagc cggaagaaat caaaggcacc gttgtgattg tgcctgtggc 469441 cggtgtcacc accgtcgtgc aaaaatcgat tcactatgcg aaatcactgt ccgatcaggt 469501 gatcgccgtt cacgtgtcat ttgacagaga acaggaaaag aaattcgaaa aacgttggga 469561 agagcttaat aacggagtgc gtctcgtgac gcttcactcc tcttacagaa gccttgtcca 469621 tccgtttgat aagtttttgg aaacagttga ggcaaaagcg aagaaggagc agttttccgt 469681 tatggtgctg tttccgcaat ttataacgaa aaaacgctgg cacaccatcc ttcacaacca 469741 atcggccttc ctcctcagag tccggctgtt ctggaaaaag gacataatgg ttgccacact 469801 gccgtatcat tttaaaaagt aaagctctag gaccaaggga atcaccttgg tcctttttag 469861 cgggaaaagg aggtatgggg gtgtatacac aaggtgcttt tgtgatcgta ttgaacgaaa 469921 gtcagcaaat tctgctggtg aaacgaaaag atgtccctct atgggatttg ccgggcggca 469981 gggttgatcc cggggaatcg gctgaggaag cggcagtgcg ggagatattg gaagaaacgg 470041 gatacaatgc agcgctttct gcgaaaatag gtgtttacca aaggccaaag tttcaagatg 470101 aacagcatct gtttttcgga agcattacag gcggacaagc aatggctgac ggcacagaga 470161 cagcgggatt aaagtgggtt tccccggggc gtttgccgct ttttatggtg ccgaatcgaa 470221 aaaggcagat caatgatttc aagaacggcg ctcaagatgt aaatgtcacc gtcaaggata 470281 gcgggttgct cgcggcgatc gacctgttga aaagaagact gggcaagtga ttcaggtctc 470341 cgggttttaa agcctttctc ctgtggtatt gaaaaaagga aaaaggagga tacgttatgg 470401 cacacaaaac tgcaggacaa gcaatgacag agctgcttga gcaatgggga gttgatcatg 470461 tatacggcat ccccggagac agtataaatg agtttatcga agaattaaga cacgaaagaa 470521 atcaactgaa gttcattcaa acccgccacg aagaggtagc ggcactggca gccgcggctg 470581 aagcaaaact caccggcaag atcggagtct gtctgtcaat cgcagggccg ggagcggtgc 470641 acttattaaa tggtttatat gatgctaaag ccgacggcgc ccctgtgctg gcgattgcag 470701 gacaggtttc ttctggcgaa gtcggacggg actatttcca ggagattaag ctggagcaaa 470761 tgtttgagga cgtggccgtg ttcaacagag aggtacatag cgcggaatca cttccggatc 470821 tcttaaatca ggcgatcagg accgcctaca gcaaaaaagg cgttgcggta ttgagcgtgt 470881 cagatgattt gtttgcggag aaaatcaaac gggagcccgt gtatacttca ccggtgtata 470941 ttgaagggaa cctagaaccg aaaaaagaac agctcgtcac ctgcgcccaa tatattaata 471001 acgctaagaa accgattatc ctggcagggc agggaatgaa aaaggcgaaa cgggagctct 471061 tagaatttgc ggacaaagcc gccgctccga tcgttgttac actcccggca aagggtgttg 471121 ttcccgataa gcacccacat tttctcggca acctcggtca gatcggaaca aagccggctt 471181 acgaggcaat ggaggaatgt gatttattaa tcatgctcgg aacgtcattc ccgtaccgtg 471241 attatttgcc tgatgacacg ccggcgatac agctcgattc agacccggca aaaatcggaa 471301 aacggtatcc ggtgacagcg ggccttgtct gtgattcggc tctcggtttg cgcgaattga 471361 cagagtatat tgaacgcaag gaagacagaa gattcctgaa tgcctgcaca gaacatatgc 471421 agcattggtg gaacgaaatt gaaaaagatg agacagaggc aacaacaccg cttaaacctc 471481 agcaggtcgt ggcccgtctt caggaagcgg cagccgatga tgcggtgctc tctgtagatg 471541 tcggcactgt gacagtctgg atggcgcgtc atttcaaaat gaacgcgaat caggatttca 471601 tcgtttccag ctggcttgcg acaatgggct gcggcctgcc gggagcgatt gcagcgagct 471661 tgtccgaacc ggaacgccag gcgatcgccg tctgcggtga cgggggattt tccatggtca 471721 tgcaggacct tccgaccgcc gttaaatata agctcccgat cacagtcgtt attttaaaca 471781 acgaaaatct cggcatgatt gagtacgagc agcaggtcaa aggcaatatc gactatgtca 471841 caaaacttca aaatgtcgac tatgccgcat ttgcagaaag ctgcggagca aagggcatca 471901 aagtgaccaa agcggaagag cttgcgccgg cttttcatga ggcgctgcac tctgaccaac 471961 cggtcgtagt ggatgtcatg attggaaacg aaccgccgct tcctggcaaa atcacctacg 472021 ggcaggcgaa aggctttagc aagtacatgc tgaaaaactt cttcgaaaac caaaaatttg 472081 aaatgccgtc actgaagaaa agtttgaaac ggttatttta aaaaaacagg ggccctaaga 472141 gcccttgttt tttttttttt ttttggaaac aaatgtattt tcagcatgtt tgaattcata 472201 aaatgatcgg tatatgtatt aggaactgat ttcgccatac tcgaaacaga caaaaggaca 472261 aatgcatctt gtttcaaagg aagatgcatt tgtccttgca tgcttattct tatcaaatct 472321 tacagaactc ttctcataat aggttatttt tcttttttct tcagcccgaa gaagaaagga 472381 aaagcagaac cgaccaagaa ggtgccgaat aaaaacatgc cgccgataaa cacgtggaaa 472441 tttgtgtgtc cggccgtaaa cgccgtgatt agggaaatga tactgagcac gatcatggca 472501 atgccgggcg cgactctcat ttttcccttg gatttatggg cagcaacaga acataaaatg 472561 ccgataacaa taggaacaat ccacaaataa aacagaataa atactgacat catcaaaact 472621 ccgatttttc ttctatcata acaaatttct gtcaaaaagg gtatcaatga gcttttgcgg 472681 aaaaataaaa accggcttta gaagccggtt tttttatcga aacgtatcta caattaaaaa 472741 cacattcaaa gcaacgatca atacagcaat cagccaagac accactgtga tccatttggc 472801 gttgatcaga gatcccatga tccgtttatt gcttgtaaac ataataagcg gaatgagggc 472861 aaaggcgatc ccgaaggaca gcacgacctg gctcagtacg agagcggtcg tcggattaac 472921 acctgacgcg atgatcaaga tcggcggaat gatcgtgata aaacgccgta catacagcgg 472981 aatgcggtag ttgataaatc cttgcataat cacgtcgcct gaaagtgtgc cgacagacga 473041 actggataga ccggcaacga gcagcccgat cccgaacaaa gccgcagaca tagggctgac 473101 aagatgtccg aattgctgaa atgcgacgtc gagatcctca acaaacaggc cgtttttgaa 473161 gaataatgcg gcagccacaa tcagcatact tgcattaata gcccctgcaa tcagcatcgc 473221 tattaaaata tcaataaatt caaacctaaa gatttttttc cgttctgcat cagttttgcc 473281 aaccacccgc cgctgtgtaa gggcagagtg taaataaatg gcgtgcggca taacagttgc 473341 gccaagaata cccgctgcaa gaagcacact gtcggtgcca tgaaacgccg ggacaaaaag 473401 gcccttcatc actgacacgg catcaggctt tgcgaaaaag gtctgcaacg caaaggcgat 473461 cacgaccaca aacagcatac cggcaatacc tgcttcaagt gagcgataac cacggcgctg 473521 aagctccaat atcgcgaaag aaccgatcgc cgcaataata gacgcttcaa gcatcggaat 473581 gccgaacagc aaatacagtc ccagagccgc tccgataaat tccgccagat cagttgcgat 473641 aatgaccaac tcgccctgaa tccataatcc gatcgagaca ggcttcggga attcttcacg 473701 ggcaacctca ggcagatttt tgcctgtcgc aataccgagt ttggcggata gggattgaat 473761 taaaagcgcc atgatattgg aaaataagat cacccataag agcatatatc cgtatttaga 473821 acccgccgaa atattcgttg cgaagttgcc gggatcaata taggcaatgg ctgctataaa 473881 tgcagggccg agaaaaggga gcagccctct gaatcctctg attttcccgt caagcgcatc 473941 ttggacggct ttggaacggg gagattgtgc tgtgatgtcc ttgttcatca tgtctcacct 474001 gaattctgtt tgtttttgcc gtacaacaaa gagtttcctt aaggcaaatt attttatcta 474061 catcatatga ccatcccggt ttcttgtcaa ccgaaaatgt tcaaaataca cttctgaatt 474121 tttccctgtt atgtaacatg atatgtaggg attcgtgata aggtcccata taaaaagaca 474181 tcgtttcatt tcgaaacgat gcctcctgta tctaatgagt ctaggcttcc ttccgcagcc 474241 cgcggaatat aaggcccagc aagaacacga agatggctgc cccgatgatg gccgggaaaa 474301 tagcaaagcc ggcgaggctc ggtccccatg tgccaagaag tccgtgccca atccaagcgc 474361 cgatcagccc ggcaatcata gagccgaaaa ttcctcccgg cagccggttt cctacaatgg 474421 cgctcccaat taatccgata acaattgcaa caactaatga aaccaaaaag ctaagcatca 474481 tgatcacctc tcataaatga tttaccaatc aataaccgct cctgatcatt tcgaaacact 474541 tgaaagcata ttcctttatg atcctgtttt aatctttctc tgcacactgc cgtcagctaa 474601 atgaacaatg acctcagtgc ctttatgcgc cgcgatttcc tttgcccgtt caatcgcttc 474661 tttctttgta tccttgattt cagacacacg tttggcgccc tcggctttga ctgcccagcc 474721 ttttttatgc ttaataacat gctctgcttt attcatgagc tcggggccgc tgccgctgct 474781 tggatcagca tcgcgttctg tctcatcatc atgcgtcagg aaatcatcaa tttcatctgt 474841 agaggcgttt tccgcccatt ccttcgcttt gcttgtcgca attggaatcg cgcgcccttc 474901 ctcatagcct tcatcaatca tcgcattcgc aatgtctatc gccttttttc tcaccggctt 474961 ctcaagattt tttaatgaag caggataatc cttcatcgac caaggcatgt ctatcactcc 475021 ttttcctttt ataaaaatgg tacccgcagg tgaaaaataa aaacgcatcc gaaaaaatga 475081 aggtatacta tatagtagaa aaaacggaag ggaagtgcgg gttgggtgcc aacagaacga 475141 aaagaagact tacatcagca attaaaagag atagagaaat gggaaaaaga tcagcaaaaa 475201 gtctggtttt gggaaaagct cagccgtctc ccgtttcaac tcctggacaa gctgacacca 475261 gaattcatcc agaaaaagat cggcaagctc ttggatgagg tcggcagctt tgttcaaaca 475321 ggcggacagt acctgacatc tgaaaaacag attatcagga tgtttcaaaa gaaactgccg 475381 gaggagatct ttgaatcgct ggaggacatc cggaaagcgc ctcttcctgt catggatgaa 475441 attgcggaag gaatgggcaa aaacagaacc aacgcagcaa ccgttcaagg cgcgacaacc 475501 ggtgtgggcg gcgtgtttac gctggcggca gacattccgg cagtgcttgg cttatcacta 475561 aaaacattac aggatatcgc agtcgcatac ggctatgacc caaaggagaa aaaagaacga 475621 gtcttcattg tgaaatgcct gcagcttacg tcggctgatg ttgtcggcaa aagatcgatt 475681 ttgcaggaat taaaacacta cgatcaagac cgtacatata agaatgtcgc ttctcaaatc 475741 caaggctggc gagaagtcgt tttgggctat cgagacacgt ttggctggaa aaaacttttc 475801 cagatagtgc cggttgccgg aatggttttt ggcgccgctg ccaatcgctc aacattaaac 475861 gacattaccg agacaggcat gatgctgtac aaaaagaggc gcattcttga acgactgaaa 475921 gaaacagaac gagagatgga atagcagaaa gcagacggac accgcgatcc gcctgctttt 475981 tttagtggaa acatacccaa tgtgttttgt ttgtttaaaa gaattgtgag cgggaataca 476041 acaaccaaca ccaattaaag gaggaattca aaatggcaga caataacaaa atgagcagag 476101 aagaagcagg tagaaaaggc ggagaaacaa caagcaagaa ccatgacaaa gaattctatc 476161 aagagattgg tcaaaaaggc ggagaagcca ctagcaaaaa ccatgacaaa gaattctatc 476221 aggaaatcgg cgaaaaaggc ggagaagcca ctagcaagaa ccatgacaaa gagttctatc 476281 aagaaatcgg tgaaaaaggc ggagaagcca ctagcgaaaa tcatgacaaa gaattctatc 476341 aagaaatcgg ccgaaaaggc ggagaggcaa caagcaaaaa tcatgataaa gaattctacc 476401 aagaaattgg ctcaaaaggc ggaaacgccc gcaacaacga ctaatcaaaa gcataaaggc 476461 agacaacctg taaataaaaa agcgatccgg cacatcagct ggatcgcttt tttttggaat 476521 cttctcaatt tatgccgcta ttgagataca ataagtgaaa aaggggtttt cgctaatgtc 476581 caagatgcaa aacttgctcg ccatcgcaaa tgaagtcaaa gaaaagcacg ccaatttttc 476641 aatctcagag gtcaacgacc actgcgtgcg ccttgcggtg tttacgggag aatatgactg 476701 gcaccatcac cctgactcag acgaattgtt tattgttctt gaaggggagc tgctgatcga 476761 ttttaaggac aaagaaaccg cggtgctcaa agcaaatgac agcctgctga tccctaaagg 476821 cacggttcac cgcacacgct cttacgtcag aacggtaaat ctctgtgtgg agcataaaca 476881 agccgaaacc gtcatcatag aggagcagcc atgctaatca aaaagatgat atgtgaagta 476941 gatgctgcaa acgctgaagc atttgcaaaa gcgcagtcac agtgggaagc gttatcgcat 477001 ataagcggct ttatcaaaca ggccggcggc tggcgaaaaa cgatagacga gccgctcacc 477061 gcagaaatca tcagtgtatg ggaaaacaga gaagcctatg atcattttat ggagaacgaa 477121 catgacagca tatacgagga aaacgatcag aaggctgtaa ttctttcgat agaggtgacg 477181 gtgtacgaag aggataaacc gttcgttcac gatctgttac ataaccccga tatccggtac 477241 gaaccaaact ggacggttct gaaggcataa tcaaagccca aaacatcatg ttttgggctt 477301 gtctctttac tcgcgtcccg gaagtgtatt atgaacaaaa ggcggtgctg gttttaactc 477361 cggtttttct ccaaacgttt ttgcttcttt cacatattca aaggcttctc cgtccggcgc 477421 tttttcattc agccagtttt gctcggcgct tacttcgcct tcagagaaat tgataagctg 477481 atgtgagaac tcttgttttt cgagcgcttt cgggaatgta cccggcacaa ccggaccttc 477541 ctgtgcttct aattctttaa tggcggcgag ccattggttc tggtgcatcg tgtcacgcgc 477601 cagcaggaag ctgagcatat ctttgacgcc tttgtcatcc gtcatttcaa acaggcgtgc 477661 gacctgcaga cggccctgag attccgcatt caggttggcg cggaagtctg ccagcaggtt 477721 tccgcttgct acgatataac cgccgctcca aggtacgcct gtactgcttt ccggcatggc 477781 gccaagtcct gatacaatcg catggtgagg gttcatgccg cctaggatgg agccgatgac 477841 cggatcttca gcagcttttt cctgctgatc aagaggggca tcctcaagaa gtctggcaat 477901 catcgttgcg atcatttcaa catgcccgag ctcctcagtt gccgtatcca tcagcaagtc 477961 cttgtatttt tcatttcctc ttgtgttcca gccttgaaat aagtactgca tggcaactga 478021 aatttctccg aattgcccgc ctaaaatttc ttgcattttt ttagcgaata atggatctgg 478081 acgatctggt ttagcaggat gctgcagcat ttttgtgtgc ttaaacatgt acccatctcc 478141 tttttcgttt atctcttttt atatttccga tcgatagaaa gataaacgaa aaacagcgta 478201 tcgagatggg aactatgaat cttttcgcag ctccaacagt tcccggatca gctcccggcc 478261 aaagatgggc tcatactgcc ggtaaacagg gtcaagacgc ttcatccatt cttgtttctc 478321 tttatctgac agctcataaa tatgtatagc agaattcttt ttgatttctt ccagctgctc 478381 cttgttcatt tgttcggcat acgtttcatt ccactccgtt gtctccttca tcgcttcagt 478441 caaaatgcgt cttgtttctg gtgtttgcgc cttccagaag tgttcatcag tcatgacagc 478501 gtagccgaga taaccgtggc tgcttattgt caaatagtcc tgaacattat aaaatttttt 478561 agaatagatg tttgaaattg tattttcttc gccatcgact acattgtttt ctaacagctg 478621 aaaggtagaa ttgaaggatt cctgatgagg tgttgcgcca agcagcttga actgatcctc 478681 aatcacatcg ctttgcataa tgcgcagatc ctgccctttt aagtcatccg gtgttttgac 478741 cggcccttga tttgttgtga tttgcttaaa gccgttcgtc caataggcca atcctttcaa 478801 ttggtttttc tttagagaat caaacagctg tgtgccgatg cttccgttca gccctttttt 478861 gacggcgttg taatctgtaa atgcatacgg cagatccagc actccccatt caggcgagag 478921 catgccgagc ttcgatgtgg agggggcgat aaattgaaca tcgccgtttt gcaatgcttc 478981 aatttcttca atgtccgagt acaggcttcc attcggaaat acttctattt ttatttttcc 479041 gcctgatttt tcgttcacca gatcagcgaa tttattggcg gccagccctt ttggcgtatt 479101 ttcagcaacc acgtggctga atttaaacac gatttgatcc tgcaggcctt cctggtcgtc 479161 atcataaaca atctttttat tgccggtatg atcatggaat ccgataaata aagcggttgc 479221 aattccagcg atcatcagtg cgagacatgc aagcaaactc ttcatgaaaa gccctcccct 479281 atgttaagga taatgggggc tatgacattc gtaaagacct gaaaggagaa gctgatgaac 479341 aaaaagaagc tctcaatccg ttggaaaatc acgatcttat cctatatact cgtcattttc 479401 tcctttttga tcggcggcat tgtgctcatc ggcaacattc agcatacaga ggagcgggag 479461 ctgaaaaagc ggctgatgaa tacggcccgg acggtgtcag agatgacaga agtgaaagaa 479521 gccttggcgc gaaaaaaaca aacagaagcg gttcgccatg cggttgaaga aatcaggatg 479581 attaatgaag cagactatat tgtcgtcatg gatatgaatc acatccgata tacgcatcct 479641 gtcagcacaa gcattggcaa gaaatcagaa ggtgcagacg aggaggcagc ttttgcggag 479701 cacatttatt tctctgaagc aaagggcgag atcggcacgg cggttcgcgc tttttatccg 479761 gtaaaggatc aagacctgaa ccaaataggc gtggtgcttg tcggaaaaac gctgccgggg 479821 atcgctgaca tcctgcttca tttaaagcgt gatatcgcct tcatcgttgt gctgacactc 479881 ggctttggcc ttgctggttc ctttttgctg gcccgccata tcaaaaaaca aatgtttcag 479941 cttgaacccc atgagattgt ccgaatgtat gaagaacgga cagcgacgtt tcactcgatg 480001 aatgaagggg tgatcgctat tgacaatcgt ctcgtcatta cgatcttcaa tgaaaaagcg 480061 aaacagatct ttgaagtgca gggggatcta atcggcaagg tgatttggga ggttctcaag 480121 gattcgcgcc tgcccgaaat cgtggagcgg aacaaagcgg tttataatga agaaattcgt 480181 gtcagcggta aggtgatcat gagcagcaga attccgatcg tcatgaagaa aaaagtgatc 480241 ggcgccgttg cgatttttca ggacagaacg gaagcggcca agatggcaga ggaattgact 480301 ggtgtcagaa actttgtgga ggcgctccgt gtccaaaacc atgagcatat gaataagctg 480361 cacacgatcg ccggtctcat ccagctgggg aaatctgaaa aagccttgca gcttgcattc 480421 caggcgtcaa ctgagcagga aaatgtgact gaatttctgc accgctcgat tcaaaatgac 480481 gctgcggcag gccttctatt aagtaaaatc agaaggggaa gagagctcgg cattgctgtt 480541 catatagatg aaaacagcag tcttcagcaa tttcccgagc atgttgatca gcatgatatt 480601 gtcgtgcttt tggggaatct gattgaaaat gccttcggct catttgaaac cgttcaatct 480661 gaagacaaac gaattgacat tagtatcgaa caaacagatg atatccttgc tattttaata 480721 gaagataacg gctgcggaat tgaaccgaca catatgcctc gcctttatga caaaggtttt 480781 acggtcaata aaactggcgg cacaggctat ggcctgtatc tagtgaaaca aatcatagac 480841 aaaggatcgg gcacgataga agttgattca catgcggggc aggggacatc tttttctatc 480901 gtttttccaa tgaaggggga ggaagcacag catggctcgt aaagaatgga aggttctgct 480961 cattgaagac gatccgatgg ttcaagaggt caataaggat ttcattacaa ctgttaaagg 481021 cgttactgtc tgtgcaacgg caggaaacgg agaggaaggc atgaagctga ttaaagaaga 481081 acagccagat ctcgtcattc tcgatgtgta catgccgaaa aaagacggca tcaagacctt 481141 gcaggagatc agaaagcaaa agcttgaagt ggatgtcatt gtcgtctccg ctgcaaaaga 481201 caaggaaacg atctcactca tgctgcaaaa cggggcggtt gactatatct taaagccgtt 481261 taagcttgag cgaatgagac aggcactcga aaagtacaag caatataaac aaaaaatcga 481321 agcgaatgat acgctgtccc aggaacagct cgatgcgatc ctgaatattc cgcagcaggc 481381 cgtacaggat ctgccgaaag ggttgaatca cttcacgatg aatgaagtca ctgctttttt 481441 gaaacagcaa accgcatccc tttctgctga agaggttgcc aaggcgctcg gcatcgccag 481501 agtgacagcc agacgatatc ttgattactt agaaaaaacc gggatcatca aattggacgt 481561 tcaatacggc ggagtcggcc ggccggtcaa ccgctacgtg ttaaaaggat aaacctgaga 481621 ccaaaaagac caaaatgtcc gttatgatca taaacttccc cagactgtat gaaaacgcta 481681 tcattctagt aagaaagaca caaaaggcga ataggacagg gggatgaagg atatgaaact 481741 gtttaaaaat ttaacagttc aggtcataac cgcggtcatc atcggggtca ttgtcgggct 481801 ggtctggccg gatgtcggca aagaaatgaa accgcttggt gatacattta tcaacgctgt 481861 taaaatggtg atcgcaccaa tcattttctt cacaatcgtt ctcgggattg caaaaatggg 481921 cgatatgaag aaggttggaa aagtaggggg aaaagcgttt atctatttcg aggttgtcac 481981 caccctcgca ctcattatcg gtttatttgt cgtcaatatt atgaagccgg gtgcgggtct 482041 tgattacagc aagcttgaaa aaggagatgt atcacaatac acgcaaaatg gcggtcaggg 482101 aatcgactgg attgaattta ttacacacat tgttccgtcc aacatggttg atgccttcgc 482161 aaaaggggac attttgcagg tcttattctt ttctattctt ttcggagtgg gtcttgcggc 482221 attaggcgaa aaaggaaaaa gcgtcattga tttcttcgac aaggtttctc acgttttttt 482281 caaaattatc ggctacatta tgcgtgccgc gccaatcggg gcattcgggg cgatggcgta 482341 tacaatcgga cacttcgggc tcgattccat caaaccgctg gcaagcttaa tgatgtctgt 482401 ttatattacg atgttcctgt tcgtatttgt tgctttaaat atcatctgca agctttacgg 482461 attcagcctg tggaattacc ttcgcttcat taaggatgag cttttgatcg tgcttggcac 482521 aagctcttcc gaatcggtgc ttccgcgtat gatggataaa atggagcgct acggctgttc 482581 caaatccgtt gtcgggcttg ttattccgac gggctattcg tttaacctcg acggcacatc 482641 catctattta tcaatggcga ctgtcttttt ggcacaggtg tttggagtag acctcagcat 482701 cggccagcaa attacgatta tcctcgttct gatgctgaca tcgaagggag cggcaggtgt 482761 gacgggaagc ggatttatcg tccttgcctc aacgctgtca gcgctgcagg tcattccgct 482821 ggaggggctt gcactcctgc tcggggtcga ccgtttcatg agtgaaggaa gagccattgt 482881 gaacctgatc ggaaacggaa tcgccacgat cattgttgcc aaaagcgaaa atgaatttga 482941 tgaagcaaaa agcatagagg ctgttgaagg catgaaaaaa atgaaaacag cagtctgaaa 483001 aaagaacggc ccatccatgg gccgtttttt taattgttta agaattatta aggtaaggac 483061 agagacctca gcattttttt gttatataat ttacaaatgg atactatatt gaatgaagga 483121 cgtttgtcct aacaggagtg tataaatggc cgctttagtt aaattttttc agcacccggg 483181 agtaaggcgt ttctccatct ttgtcgtgtt aactggtgtg ttatatctat ttaagagcat 483241 gatcaactta atattgctta ccttcatttt cacatttcta atggatcgtt tggagcttgt 483301 cgtgcggcag tttgtaagcc agttcttccg cgtgagccag cgggttgtca ttacgtttct 483361 ttacatgttg ctggctgtgc tgcttacagt cgggggcttt gtgttttatc cggtcgtcgc 483421 ggcgcagatc cagcagctgg taaagcagat taaacatatt gcgtatcatc ctgacagcat 483481 ccctttcttt gatgagatca ccagtgtctt cggagatatt aacatcagtt catatgtcaa 483541 agagggcttc aatgtagtgt atacgtatct ggccgatatc agcacattcg gcttgcaggt 483601 cgtgatggcg ctcattctta gcatgttttt cttatttgag aaaaaacggc tttctgaatt 483661 catggcgaaa tttaaaacga gcaaacttag ggtcttttat gaggagattg cttttttcgg 483721 aagcaaattt gcaagaacgt tcggcaaggt gctcgaggct caatttatca ttgcgctcgt 483781 caactgtatt ctgacgttta tcgcgctttg gattatgcat tttccgcagc tgtttgggct 483841 ttcgattatg gtgttcttcc ttggattgat ccctgtagca ggcgtcgtca tttccctgat 483901 tccgctcagc attatcgcct acagcactgg cggtggaatg tatgtgctct acattgtcct 483961 tgtcatattc gccattcatg cgatcgaaac ctatttctta aatccgaagc tgatgtcggc 484021 gaaaacagag ctgccaatct ttttcacctt cacagtactc attttctctg aacacttctt 484081 cggcatttgg ggtttaatta tcgggattcc gatctttgtg tttctccttg atattctgga 484141 tgtcaccaac aaggaagata ggtctaaagg accccgagag aatagcgata aaaagtagtt 484201 taaaatcgaa taatgagtgt gcctcgatct gccggcctgc ctgttcaggg catggaatta 484261 agactcggaa tcggagcttg gcattgcctt gcacagtggt gaacacaaca ggtgacaatg 484321 cttgtcatca gtacggaaac tgaaaagaac aaacagtcgg agcaaacgct catcatcggt 484381 ttaaccaaac atttggaagc aacaaatgct ataatacaaa cagtgcctaa tgttgggcac 484441 tgtttatttt ttgtcgaaaa aggaggaagg ctttatggct gagccgattt tacatattga 484501 aggcctcgat aaaaaaattg ggtctaaaca gattttaaaa cagatcagca tggacgtcat 484561 ggagggtgaa atcatcggcc ttctcggtcc gaatggttcc ggaaaaacaa cactcatccg 484621 tatcatcgtc gggctgttga aacaaaacag cggaagcgtg acaatcagcg gattccagca 484681 tgatacagag tttgaaaaag cgatggaagc ggttggagcg attgttgaga accctgagtt 484741 ctatccgtac ctgacaggct gggaaaacct caagcacttt gcgaatatgc acaaaaaaat 484801 agcggatgaa cggcttgatg aagtggtgga acgtgtcggg ctgacgtcag cgattcatga 484861 taaggtgaaa acctattccc ttgggatgcg ccagcgtctg ggaatcgccc aggcaattct 484921 tcaccggccg aagcttctca ttctagatga accgacaaac ggcctcgatc ctgcggggat 484981 gaaggatttt cgggatcata ttaaggaact cgcagaaatg gaaggaacag ctgtcctgtt 485041 cgccactcat ttattgcgcg aggttgaaga cttgtgcgac cgtgtcatca tcattcaaaa 485101 aggtgagatc aaagcggaag tcagcttaca aggaaccgat caaaccacag aaaaagcgat 485161 tatagaagtg cagccgcaag aaaaagcgct caattggctg acaggcaatc aatatcaagc 485221 tgagagccaa gacgggacga ttgtagttga ggtggcaaaa gaaaacatac cggagctgaa 485281 ccgatcactt gtcggacaag atctgaatgt attttccatt acgccttaca cgcagtcact 485341 ggaagacgaa tttataaaag cgacaacagc tcatcaagag gagggagaag agcttgtcta 485401 aattaatttg gaatgaacat atgaaacttt ttaatcggaa ggtcactttg gtttctctta 485461 tcctgatggc tgtctttcaa ttcttcatgg cattgatcat taaacggatt gtcatcagtg 485521 ccggaacaga tgaaaacttc atcggctatt tatcgtatac accgagcctg aacattttgc 485581 tgcaggcttt aacgatcgta attgcagcaa caattgtttc gatggaattt gataaaaaga 485641 cgatcaaatt tttgctcatt cgtccggtta aacgccaaaa ggtcttttgg tcaaaattaa 485701 tcacagtcgt gatggtcagc ttctatttgt atttggcata ctacattctg gcattattat 485761 tcggtctctt gttttttggc acatcggtga ctgcggaatc aaagacattg ctggtcaaca 485821 ccttggcgct gatcgggtca aactggcttg aagctgtaat gatgggatta ttcgggctgc 485881 tttgttcttc gctgttccgc aatagcgcgg tagcagttgt tgtttctttt gtcgttttat 485941 acggagcgag tacacttgtt cagctcatga agttgtttga aaacaagtgg ggcagctttt 486001 tgctttttgc gaacactgac tttacgcaat acagaagcgg agagacagcg ttgttttcag 486061 gcatgacgcc attgttttca attggaattc tcatcataca tgccatattc ttcatcgttg 486121 ttggctggtg gtgcttctgt aaacgggatg ttcgggtcta aaggcaagga atgacatttt 486181 tgtgaaaaag ctcacgtaaa tcaatatcat ttgatatttt ggtttatact aaaggtactg 486241 acggaggtgt ctcgattgag gaactttatt accgctttac cgatcgtatt gctgcttgga 486301 ttctcatttg tgtcattcat gtttcagttt gaacatcttg tttatttcag gctcgcgctt 486361 gggttgtttt ctctcgtggg actgtacatg atatataaaa tgaagacggg catccgctat 486421 tttatcatct atctgtatgc cagctggatt gtgttggccg cagtgaccgc ttttgaagag 486481 ccgattttct caagcttttt ctttggcggc ctggtgatga cgatgggtta cctgacatat 486541 atgctgattt atctcggcat gaaacaagac cgggatgcaa atcctgtgta atcgcgctgt 486601 tcccttgggg aacggcgtgt ttttctatac tgggcaaaag gttaacagtt gcggaaaaat 486661 ggcaggaaat ctataataca tattaaattt atcggaatta aaactggggg gctgccggat 486721 gtcattattt atacaaaacg atcaacagcg gcaatggatg gagaaaatcg gacggattgc 486781 ggatgaattt cagcaaacag ctgctgaaga tgacgaacag ggacgttttc ctgcagagaa 486841 aatacaaaaa ctgcgtgatg ctgggtatac agcattaaca ttgccggcat ctcatggcgg 486901 agggggcatt tctgtttacg atatgctctt gtttcaagaa cggcttgcac ggggagatgc 486961 tccgacggct cttagcatcg gctggcattt gagcgtgatc ggggagcttg gagaaggcaa 487021 cagctgggat gaagacgtat ttgcatttgt tgccaaggaa gtccaaaacg gagccgtcat 487081 taacagggcg gcgactgaag cgaaaaccgg aagcccgaca agaggagggc gtcccggtac 487141 acacgccgtc aaaaaggatg gcaaatgggc agtgaacggg agaaaaacct ttacgacgat 487201 gtcacaagct ctggattatt ttttagtaac cgcatggatt gaggacaaac aaacaacagg 487261 cgtgtttctc attcataaag atgatcccgg cttgtcgatt gaagaaacgt gggatatgat 487321 ggcgatgcgg gcgactggga gccatgacct tgtactgaac gaagtaatgc ttgatgagaa 487381 taagctggtg gaactgcttc aagggcctcg tggagctaag ccgaatggct ggctgcttca 487441 cattcctgcg atttatcttg gtgtggctca agctgctcgt gactatgcag tgcaatttgc 487501 atctgagtat tctccaaaca gcttgaatgg accgatcaag aatgtcccgg ccgtacagca 487561 aagaacaggc gaaatggagc ttgaactgct caatgccaga cactttcttt tccatatcgc 487621 tcaattgtat gacgatccgg tgcggcgtcc acacttgacc agcgagctcg gtgcggcgaa 487681 acatatcgtc acaaacgctg cgctgtctgt tgttgataaa gcgatgagaa ttgtcggggc 487741 caaaagcctg gaacgaacca acccgcttca gcgctattac cgtgatgtgc gcgccggtct 487801 tcacaacccg ccgatggatg acgccgtgat acacaagctg gcagctgaag cgtttgagtc 487861 ataaaaaaaa gagccttacc ggctcttttt atgtattgtt ttgctcttgc agattttttt 487921 gatgcttgcg gtcgatcctg tcataaataa cgttcatcag ctttggattg cccataatcg 487981 cctctttgtt ttcctggatc agctgttggt aagttttcac tttacgcttc ggcatgctcc 488041 ggcgccctcc tgacatgttt gtattcactt tctaactccg tcagcgacaa ttcatacaga 488101 tgacgctttg actttttgta tataccattc tgtattaaca gatgaatgag ctgttttttt 488161 ctgatttctg cagactgagg tgtcattgtg tcaccaacct ccaatcaaac gatattgata 488221 atcattatca attaacttca gtatacaatg tccgcaatag cctgtaaaga tgaaaagagt 488281 cctattcttg gccaatttac aaacattcaa caaatcgaca aaaagtttcc cgggcaataa 488341 tttgctgtcg aaatattccg cttcattgaa cgcaccctgc tatttttcat gttttgaacc 488401 atactatgta atagaatgga ggctggtatt caatggagcg gacagaaaat ctgaaaaagg 488461 gagaaaaagg ggcgctcctc aatatttttg catatgtcat ccttgctgtt gtaaagctag 488521 ttatcgggat tctatatcat tctgaagcgc tgagagcaga cgggttaaat aatggaacag 488581 atattgttgc gtcagtagca gtgctgatag gattgcggat ttctcaaaga ccggctgaca 488641 gcgatcatcc atacggccat tatcgggctg aaacaatttc gtctcttgtt gcgtctttta 488701 ttatgatggc agtcggcatt gaagtgttaa tcggcggagg aaaagcgatt gcgggcggca 488761 caacggaaac gccaaatctt atcgcggcat ggacggcgtt aggcagtgct gtgtttatgt 488821 atggcatcta tttatataac aaaaggctgg cagcgtccat taaaagctct gccctgatgg 488881 cagcggcaaa ggacagcagg tcagacgctt ttgtaagtgc cggcgcgttt atcggtgttt 488941 tttcgtccca gctgaagctg ccgtgggttg atccggtaac ggcttttatc atcggcatca 489001 tcatttgcaa aactgcgtgg gatatcttta aagacgcttc acattcctta acagacggct 489061 tccatttaaa agatcttgag ccttacaaac agaccgtcgg caggatcgaa aatgtgcatc 489121 gcctaaagga tgtgaaagcg aggtatttag gcagtacagt tcatatcgag atggtgatta 489181 cggttgatcc gaagcttaca gtagaagaag gccatggagt ggcggatgaa gtagaagaca 489241 aaataaaaca tgaacacgat gtcactcatg ttcatgttca tgtagagcct gacgacataa 489301 aataaggctg tttaacgaat tagcttatat gttcagataa aaattcagtc acttcttcag 489361 gcgttttggc attggcgctg tgaaggtgag ctgttttttc accgttcttg aaaataagca 489421 ggctgggaat gcccattact tggtattttt cagccaggtc aggaagctcg tccttattca 489481 gctcatacca gtcgttttgg ttgtattctt ccaaaatatc gccgatgaac atattcatgc 489541 gtgtgcagtc tgggcaccaa tcagcataaa actttacaat gatttcttta tcagattgaa 489601 tcagttcatt aaattgttcg tttgttgtga tttttttcat atgtcacatc tccttttcaa 489661 tgccatttta atataaaata aaaaggaatt acatacaaat gcattcaaca tcagcatgcc 489721 caaaaataat tagatcattt tccggtgaaa atgataagat agtaaagatg aattgtagtg 489781 gggggagtat ccattgaaaa caagtctagg attagtgtac ggaggaaagt cggcagaaca 489841 taatgtttcc ctgcagacag ctctggctgt aatcaaagcg ctaaatactg agaagtttga 489901 tatacatccg atttatataa cagaaaaagg cgaatgggtt agaggcgccc gtttaactga 489961 acctgtttca aacgtgaaaa tgcttcaatt tgagcaagga ggcagtgctt tttctccagc 490021 tgccctgaac caggagatgt ttccgcagga agcgtcacag caaaatgaag ccatcgacgt 490081 cgtattcccg ctcctccacg gaccgaacgg agaagacggt acgatccagg gaatgctcga 490141 gctgttgaac attccttatg tcggcaacgg agtgcttgct tcctcagctg gcatggataa 490201 agttgtcatg aaacatttat ttgcgcaggt tggccttgct caggctaaat acgcagcttt 490261 ccttaagaaa gactggactc gttctccgaa agaaagctgt gaggaggttg aacaggaatt 490321 aggctaccct tgcttcgtaa aaccggcgaa cctcggctca agtgtcggaa tcagcaaatg 490381 ccgaaaccgt gaagaactgc aaaaagcgtt tgagcttgct ttccaatatg accgcaaagt 490441 cgtcgttgaa gaaggaatta acggccgcga gatcgaaatc ggcgttcttg gaaatgatga 490501 tcctaaatgc tctgttgtgg gagaaatcgc accgaagaca gatttctacg attacaaagc 490561 gaaatatgag gatggagata ctgatctgat gattccggcg attgtgactg atgaggaata 490621 cgcaacaatc agtgatatgg cgatcaaagc gtttaaagcg atcgacggtt caggactcgt 490681 cagagcggac tttttcctga cagctgacgg cgaagttctg atcaatgaag tcaacacaat 490741 gcctggcttt acacctttca gcatgttccc gttgctctgg aaagaagccg gagtggaata 490801 tgctgacctg attgaacagc ttgtggagct tgcaaaagaa cgccacgctg aaaaacaatt 490861 gattaagcat acattctaat gaagaaggac actgccggta aaagggcagt gttttttccc 490921 gtatatacaa aagaaagaga gggaccttac ttgattaagc gaacagtaaa aaacattgcc 490981 gaaatggtta aaggcacact agcaaatccg caatatgaac aaacagtcat tcatggagtg 491041 gcaaccgata caagaaaact ggaacaacat cagctcttta ttccgctgaa aggggaacgt 491101 tttgacggcc actcttttgt ggagcaggcc tttgaagctg gtgtagcggc tgttctttgg 491161 gatcggtcag taccaaatcc gcccgagaat cacgccgtca ttttagtgga cgataccctt 491221 actgcacttc agcagcttgc aaaagcttat ttgcaggagc ttggcacgcg tgtcatcgga 491281 gtaaccggaa gcaatggcaa aacgacaaca aaagatatga ttcacgccgt attggggacc 491341 cagtaccgtg tccacaaaac tggaggaaac ttcaataatc atatcggttt gccgctgacg 491401 gttttagcga tgcctgaaaa tacggagatc gccgtattgg agatgggaat gagcgccaaa 491461 ggagaaattg acctcttgag ccgactggca aacccggatg cggcagtgat tacgaatatc 491521 ggcgaatcgc atatgcaaga cctcggctct agagagggca tcgcggaggc gaagcttgaa 491581 atcataaacg ggcttaaaga agacggagtg ctgatttata tcggggacga accgcttctt 491641 caaaatgcat acagctgcca gacgaaaacg tacggtacgg gaacgcataa tgattatcag 491701 cttcaggatg tcagccagag tgaggaagga acccatttta caatcaaagg gatagaaaac 491761 acgtttttta ttccaatact cggcaagcac aatgtgatga acgccatggc tgcaattgct 491821 gcaggggctt attttggcat cgcgcctgag gatgcggcaa aaggactgag cggcctaaag 491881 gtaaccggga tgaggcttga actcatcaaa acagacagcg gcctttcgat aatcaatgac 491941 gcttataatg cgagcccgac ttccatgaaa gctgcaattc aattgacaga aagccttgaa 492001 ggctacggca aaaaaatgct cgtgctcggt gatatgcttg aactcggcga tcttgaagaa 492061 acgttccata aagagtgcgg cgctgtgatc agccctgata aaattgaccg cgtctttacg 492121 tacggaaaac tgggagcttt tatcgcggaa ggcgccctga aacactttga gaaagaccgc 492181 gtcagccatt acactgagaa aaaagatctc cttcaagctg tgaaggaaaa cgcatcaaaa 492241 ggcgatttga ttttattcaa agcgtccaga ggtatgaagc ttgaagaaat cgttaaagat 492301 ttaatagaga gcccgctttc ataagaaaat attttgcgaa aaaacgcata ttgcatcata 492361 aaataacctg atatgcaaac actaatgtat gccggccgaa aattatgtat atctggccgg 492421 ctgcggctat gatacaatat atataggtta tttcgcgata cgaacatatt cgtccggact 492481 tttcatcgtg acccgaagtt ctccgctgga ttcttgggag cggatggagc agcagccggc 492541 atattcgaga tgccgatctg cttctcatct tattgaaaaa caaatagtgt aatggtaaga 492601 taaaacttaa agtaattcgg gctttgtata cggatggatc ctgtccttct tgtctaaagg 492661 gcagttttat aagtggtaaa tcacgacatt actgaaacag caattagaag gagtttgaat 492721 aatttgacta taacgtttca agattttaat ttaagttctg atctcatgaa agcaattaat 492781 cgtatgggat ttgaagaagc aacaccgatt caggcacaaa cgataccgct cggactttca 492841 aataaagacg tcattggaca agcgcaaaca ggtacaggta aaacagctgc gtttggtata 492901 ccccttgttg aaaaaattaa ccccgagtct cctaatattc aagcaatcgt aatcgcgcca 492961 acccgtgaat tagccattca agtatctgaa gaattgtata aaatcggaca agataaacgt 493021 gcgaaggttc ttcctattta cggcggacag gatattggac ggcaaatccg ggcgttaaag 493081 aagaatccga atattattgt cggaacacct ggacgtcttc ttgaccacat caaccgccgc 493141 accattcgtt taaacaatgt aaataccgtt gtaatggatg aagcggatga aatgctgaac 493201 atgggattca ttgacgatat tgaatctatc ctttcaaacg tgccaagcga gcatcagaca 493261 cttctgttct ctgccacaat gcctgcgccg atcaaacgca ttgcagagcg cttcatgact 493321 gagccggaac acgtaaaagt aaaagcgaaa gaaatgacgg tttctaacat tcagcagttc 493381 tatttggaag tgcaagaacg taaaaaattc gatacactga ctcgccttct tgatattcag 493441 tctcctgagc ttgcgatcgt attcggacgt acaaaacgcc gtgtcgatga gctggctgaa 493501 gctctgaacc ttcgcggata tgcagctgaa ggtattcacg gtgacttaac gcaggcgaaa 493561 cgtatggttg cgcttcgtaa atttaaagaa ggcgcaatcg aagttctagt cgcaactgat 493621 gttgccgctc gcggacttga tatctcaggt gttacacacg tatacaactt cgacgtgcct 493681 caagatcctg aaagctacgt tcaccgtatc ggaagaacgg gccgtgcagg aaaaacaggt 493741 atggcgatga cgttcattac accgcgtgag aaaagcatgc ttcgcgcaat tgaacaaaca 493801 acaaaacgca aaatggaccg catgaaggag cctacacttg atgaagcgtt agaaggtcag 493861 caacaggtta ctgttgaacg tcttcgcaca acaatcagtg aaaacaacct gaacttctac 493921 atgacagcgg cagctgagct gcttgaagat catgatgcag taacagtggt tgcggcggct 493981 atcaaaatgg ctacaaaaga gccagacgac acaccggttc gcttaacaga cgaagcgccg 494041 atggtcagca aacgctacaa gaaccagcgc tcttctaaac gcagagacgg tcaaggcggc 494101 ggctaccgcg gcggaaaagg gaaaagcaac aaccgttctt cctatgacaa aaagcgttca 494161 aacgatcgcc gttcttcagg tgacagacgc cagaaaaaat cttactaatt tgatcgattc 494221 agagcccaaa acatgatgtt ttgggctttt ttatgttcgt gatttgttat tcagcaaact 494281 ttcagctgac ggaagccatt tttctctgta tgcttaagaa tgaaaccttt ctgtaaaaga 494341 gacgtataaa taacgacgaa aaaaagggag gtaggtattt ttgagagagc agccaaaaaa 494401 ccaaatcagt ccagacggat taaaggtttg gcgacttcaa gagatcatca tatccgctgt 494461 ttgcttgctt attgtcattg cagttgcagt gttaagctat tattttcatt ggccgtactg 494521 gatcagcggc gtgctcggcg ctgtttggct gctgggatcg attgtgacgg tctttatcat 494581 tccgaaggtc cgtcataagg tgtggcgata tgaagtccat gaacatgaaa tagatattca 494641 gtcaggtatt tttgtggtga cacgtgtgat tgttccgatg gtcagagttc agcacgtcga 494701 tacgtcacaa gggccattat taaaaaaata caacctggca acggtgaaaa tttccacagc 494761 cgcgaccgtt cattcgatcc ccgctttaga gatggaggaa gcggatcggc taagagactc 494821 catttcccgt ctggcgaggg tgactgacga tgatgtctga accgaaacgc ctgcacccgg 494881 tggcagtcat tttgaattta tgccatacca ttattcaaac gataaaaaat atcattctgc 494941 cattcttttt tgtgtatatt gtcaattcaa accatactgt ccgtttttac ggagccattg 495001 cgctcggtgt gctgttcatc tggcttgtag cggcaagcat tatcaaatgg agaaggttta 495061 cctatcgaat tgaagatgat gaatttagaa ttgaagaagg cttatttgtt acgaaaaaac 495121 gatacatatc gattgatcgg attcaaacaa tgaatacgag cgcgggcctt gtccagcaaa 495181 tctttaagct tgtgaagctg caaattgaaa cagcaggcgg aggcaaggag gcagaagccg 495241 ttctttctgc tatttctgtt gaagaagcgg aacgcatcaa agaagctgtc tttaagaaaa 495301 aagcgcaaag acgagaaaat gaacttgatg aagaacggct tgaagctgaa gaggagttgg 495361 atccgtccgt tgaggtgcaa gagcactatc gcatgaacgc gaaagaattg ctcatggccg 495421 cttctacctc cggcggaatc ggagtcatta tctccgctgt atttgcactt atttcccagc 495481 ttgatgaagt gctgccgatg gattggttat tcgataaatt ttccttcctt cagcacgcca 495541 gcatcggtat ttatgcggta ctcattttta tcggtttatt tatcgcctgg attttcagca 495601 tcgcgggcat gatgtttaga tacgcgaact ttcaaatcat aaaaaaagag caggaactgg 495661 tgatttcaag gggaattatt gaaaaacatc aagtcacgat tccgctgcga aaaatacaag 495721 ccattaaaat caaagaaaat atcattcgcc agcttttcgg ctttgtaacg gtgtccatcg 495781 tcagcgcagg aggcggcgac cgggaaaaag aagaaggcgc tttgaccatt ctctttccaa 495841 tgattcataa aaaaaagctt ccgcacatgc tccgaacatt tacgccggaa tacacgctgg 495901 aagaaaactg ccgccgcctg ccgcggcgcg cgttgaaacg ctatttgttc cgttctgtca 495961 ttttttcact ctttttgatc atcccgttat gtatcttctt tcagccatgg ggctatctgt 496021 cagtgatcct gctgccgata gaattgctct tcggctatct cgcgtataaa gaggctgcat 496081 ggacgatcaa cggggaccgt cttcagctga cgtctagatt tataggcaga acaaccgcca 496141 ttgtactgaa aaaacgaatg caggtctgca agttcagcca atcctatttc caaaagaaag 496201 gccgcttgta taccatttct acttcggtga aatcatcgag ccatatggaa gagttaacgg 496261 tgagggacgt aggtgaagag gatgcagcct tcattttaaa gtggtactca tatgaaaaag 496321 cggacggtta ataccgccgc tccagcgtgt cggcaaaccc tcgcattcgt tgtcaggact 496381 gcgcttcggt gctcaatgcg aagtggatca acggctaaat tctcaggcgt cctgcctaaa 496441 cgccgtcgtc atcacatcct gtgaaagtcc gctcctatgc tcgtccttcc tagacttcat 496501 gggttttcaa tcacgctgaa aagatgacaa aatcctaaaa tgaaaaccat tttaggattt 496561 tgtcaacaat ctgaagcggc ggttaatacc gccgctcttt tttttgcacg cataaaaacg 496621 aaagaagaaa cccgccgcat agtccaaaca aatgggccat catgttaata ttggagttga 496681 taaacgacat gagaacggca aatgcgagca gtgtgatgat cattttggaa tgctcctgcc 496741 caattaactc attgcgaaaa agaaccataa acaggtatac gccaaatagc ccgaaaatgg 496801 cgcctgaagc cccgacatgc acgtaatcaa gcggctctgt aacataagtg ccgatattgc 496861 cgatgatgcc ggagccggcg tatacaagaa ggaaacgcgc ttttcccagc atgcgttcca 496921 aagccggggc aaataaaaag atggacatgg aattaaacag cagatgtgtg aaaccggcgt 496981 gcagcaaaat cggtgtgata agccgccacc attcaccgtt tgcgacacct agattatagc 497041 ctgtgacggt atccctccat aacacgactg aatgggcagg aagtgaaaaa aacagccaga 497101 gaacagcttg caaagccaat ataaaggtga caacggggta aagcctgata aatgtttgaa 497161 aattttcagt ccgtataaac attccgagcc ccttttcttc attttggtat atctatagta 497221 acacgtttat gagacaaacc atttaaatag tacgtacgca aaggaggtta tcatacatga 497281 tttacggcat tgggctggac attaccgagc ttaaacggat cgcctctatg gctgggcgcc 497341 agaaaaggtt tgccgagcgg attttgacgc gaagcgagct tgaccaatac tatgagcttt 497401 cagagaaaag aaaaaacgaa tttctcgcgg gcagattcgc ggcaaaagaa gcgttctcga 497461 aagcatttgg caccggcatt gggaggcagc tcagctttca ggacattgaa attaggaaag 497521 accaaaatgg caagccctat atcatttgta cgaaactgag ccaggccgcc gttcacgtat 497581 cgatcactca tacaaaagaa tacgctgccg cgcaggttgt gattgaaagg ttgtcaagct 497641 agtctgcata ttagggaaac cccactcata tatttgatag tgcattaagg gagacaagtt 497701 gtttgaggct tttatggtac gcatctgttc tgcctaaacg tgtaccgagc gtaccgttaa 497761 agtcaaacaa gcgatttctt ccttttacat caattgagaa aaaggggttg aaaaaggtga 497821 gaaaaagctt tgttttgctt ttaacgggac tgcttgctgt tcttattctt tctgcctgcg 497881 ggcaaaaaac acagcaagat attgtggccg ggttagatga aaaggcgaaa gaatacacct 497941 cgtacaaagc aaaagcgaaa atgaccatcg agacagggag tgagcctcaa gtatacaatg 498001 tggaaatctg gcacaaaaag ccgtctctgt acagggttta tttagaaaat ccgaaaaagg 498061 accaaaacca agtcatttta cgaaatgaaa acggagtatt cgttctcacg ccgtctttaa 498121 ataagagctt cagatttcaa agcgattggc cgaacaacag cagccaggtt tatctgtttg 498181 aatcgctcgt aaaggatgtt caaaacgatt cggatgcagt tttcacagcg aaagaaaaga 498241 aatacgtatt tgaaacaaaa acaaactatc agcataacaa aatgctgccc acgcaagaaa 498301 tcacatttaa caaaaaagat atgagcccgt catctgtcaa agtgatggat actgaccgga 498361 aagtgatggt caaagtagaa ttcagcagct ttgaatttaa taaacaattt gataaagaat 498421 catttgatga aaagaaaaat atgacccttt ctcaaatgga tgtcgccaca agcgcaaagc 498481 cttccgatac atttgcggtc aaaacgccgc tggaactgcc gcttggcgtc aagctgcttg 498541 aagaaaaaga tatatctact gaagacggga agcgcatcat catgacgtac ggaggagaaa 498601 aatcatttac gttaattcag gaaaaagccc agattgccaa ggcttcctcc tccgttacgc 498661 tgaacggcga accggtaaat ctcggctaca ccatcggcgc cctgtcggat gcatcattat 498721 catggacata tgacggcgta gattaccttc tctcttctaa agatctttct aaagaggaaa 498781 tggtgacagt agcgaaaagc atgcagggac aatcatcgaa ataaccgcca aaggccaaac 498841 atgatttggc ctttttttcg ttagacatcg tttcccttta gcctttaatt ttagtatgat 498901 atgtaaatga tattgaataa aagctaggaa gtgtcgtaat gagcacaaaa cctttttaca 498961 gagatacgtg ggcggaaatt gacttgtccg cgataaagga aaatgtcagc aatatgaaaa 499021 aacatatcgg tgaacatgtc cacttgatgg cagttgtgaa agcaaacgcc tacgggcatg 499081 gtgatgcaga aacagcaaag gctgctcttg acgcaggtgc ttcatgcttg gccgtggcca 499141 ttttggatga agcgatttca ctgcgcaaaa agggattgaa ggcgcctata ttggtgcttg 499201 gcgcggttcc cccggagtat gtggcaatcg ctgctgagta tgacgtgacc ttaacaggtt 499261 attctgttga atggcttcag gaggcagccc gccacacgaa aaaaggttct cttcattttc 499321 atctgaaggt cgatacgggg atgaacagac ttggtgtaaa aacagaggaa gaagttcaga 499381 acgtgatggc aattcttgac cgcaaccctc gtttaaagtg caaaggggta tttacccatt 499441 ttgcgacagc ggatgaaaaa gaaagaggct atttcttaat gcagtttgag cgctttaaag 499501 agctgattgc tccgctgccg ttaaagaatc taatggtcca ctgcgcgaac agcgccgctg 499561 gactccggct gaaaaaaggc ttttttaatg cagtcagatt cggcatcggc atgtatggcc 499621 ttcgcccgtc tgctgacatg tcggacgaga taccgtttca gctgcgtccg gcatttaccc 499681 tgcattcgac actgtcacat gtcaaactga tcagaaaagg cgagagcgtc agctacggag 499741 ccgagtacac agcggaaaaa gacacatgga tcgggacggt gcctgtaggc tatgcggacg 499801 gctggctccg aaaattgaaa gggaccgaca tccttgtgaa gggaaaacgc ctgaaaattg 499861 ccggccgaat ttgcatggac caatttatgg tggagctgga tcaggaatat ccgccgggca 499921 caaaagtcac attaataggc cggcaggggg atgaatatat ttccatggat gagattgcag 499981 gaaggctcga aaccattaac tatgaggtgg cctgtacaat aagttcccgt gttccccgta 500041 tgtttttgga aaatgggagt ataatggaag taagaaatcc tttattgcag gtaaatataa 500101 gcaattaact tacctaaatg gagaattcat aaaacagctt tgcttgaaga gtgaataatg 500161 gtatcattat cactggatgg ataaaagagt cgtatccgta agtttggtgg aggtgtatgt 500221 tttttgtctg aatccagcgc aagaaccgaa atgaaaatca gcttgcccga aaacctagta 500281 gctgaattgg atggtgtagc gatgcgggag aaacgaagca gaaacgaact gatatcacaa 500341 gcagtgagag cgtatgtcag cgaacgaaca actcgtcaca accgtgattt gatgagacgc 500401 ggctatatgg aaatggcgaa aatcaacctg aatatttctt ctgaggctca ctttgcggag 500461 tgcgaggctg aaacgacagt tgagcgctta gtcagcggag gataatcatt tgattgtgaa 500521 acgcggcgat gtttattttg ctgatttatc tcctgttgtt ggctcagagc aaggcggggt 500581 gcgcccggtt ttagtgatcc aaaatgacat cggaaatcgc ttcagcccaa ctgctattgt 500641 tgcagccata acagcacaaa tacagaaagc gaaattacca acccacgtcg aaatcgatgc 500701 aaaacgctac ggttttgaaa gagattccgt tattttgctg gagcaaattc ggacgattga 500761 caagcaaagg ttaacggata agattactca tctggatgat gaaatgatgg ataaggttga 500821 tgaagcctta caaatcagtt tggcactcat tgatttttag acatatttgc aggttgctca 500881 aatagagcaa ctttttttgt tttcaaaaaa cataaacgat ataatagtga aataacgaaa 500941 aaatatgttg ttttttattg ggaggtaagc gaatttgatg tcgaaccaga ctgtatacca 501001 gttcattgcc gaaaatcaaa atgaactgct ccaactgtgg actgacacac taaaagaatt 501061 aagcgagcaa gaatcctatc agctgactga ccaagtgtat gaaaatatat ctaaagaata 501121 tatcgacatt ctgctgctgt ctgttaagga cgaaaatgct gctgaaagcc aaatcagcga 501181 actggcgctt cgagcggtcc aaatcggact gtctatgaag tttttggcta ctgcacttgc 501241 cgaattctgg aagcgtctct acacgaaaat gaatgataag agattgccag atcaagagag 501301 cacggaatta atctggcaga ttgatcgctt tttcagcccg attaacacag aaatttttaa 501361 tcaatactca atctcatggg aaaaaacagt atccctgcaa aaaatcgcgc tgcaagagct 501421 gtctgcgccg cttatcccgg tgtttgaaaa tatcactgtg atgcctcttg tcggaacaat 501481 tgataccgaa cgcgcgaaac gaattatgga aaaccttctt aatggcgtcg tcaaacaccg 501541 ttcccaagtc gtgctgattg acattacagg tgtccctgtc gtcgatacga tggttgccca 501601 tcatattatt caggcatcag aagctgtaag gcttgtcgga gcaaaatgcc tgctggccgg 501661 aatccgtccg gaaattgctc aaacaatcgt caacctgggg attgatttat cccaagttat 501721 aactaagaat accctgcaaa aaggaattca aacagcattg gaaatgacgg atcgaaaaat 501781 cgtttcattg ggggaataac attttgagac atccgaaaat cccgatcttg aaactgtata 501841 attgcttatt agtgtccatt cagtgggaac ttgatgacca gacagcatta acttttcaag 501901 aagacttatt aaataaaata tacgaaacag gtgctaacgg agtcgtcatt gacctgacat 501961 ctgtggatat gattgattca tttatcgcga aagtgctggg ggacgtcatt acaatgtcta 502021 agttaatggg ggctaaagtc gtcttgaccg gcattcagcc cgctgtggca gtgacgctga 502081 ttgaacttgg aatcgcgctt gaggaaatcg aaactgcgct cgacttagag caggggcttg 502141 agacattgaa gcgggaattg ggggaatagc gaatgaacga ccaatcctgt gtaagaatca 502201 tgacagaatg ggatattgtg gccgccagac agctgggacg aaacgttgcg aaagaactgg 502261 gtttcggcac ggtagaccag gctagaatta caacggctat ttcagaatta gccaggaata 502321 tttatttata tgccggcaaa gggcagattg gaattgaaca ggtcgcagac agaggaaaaa 502381 aaggcctgaa aatcatagcg gaagaccaag ggccgggaat tcctgatatc cgaaaagtca 502441 tggaagacgg gttttcaacg tctggaggac ttggtgcggg acttcccggg gtcaaaaggc 502501 tgatggatga attcagctta aattccgtag cgggggaagg aacagagata caagccatca 502561 aatggcttcg gtaggaggta agaacgtgga ttttagggag gttattgagc agcggtatca 502621 tcagctgctt agtcgatata tagccgaatt aacagaaaca tctttatatc aagcccaaaa 502681 attcagccga aaaacaatcg agcaccaaat tcctccggaa gaaatcatca gcattcacag 502741 aaaagtgctg aaggagctgt atccaagtct cccggaagat gtgtttcatt cgctggattt 502801 tttaatagaa gtcatgattg gctatggaat ggcttatcag gagcatcaaa cccttagagg 502861 gatacagcag gaaatcaaat cagaaattga aatcgcggca aatgtccagc agacgcttct 502921 cggaactaaa gttcctcagg aggaagcgct ggatatcggc gccatcagtg ttcccgctaa 502981 acagatgagc ggtgattact accactttgt caaagacaag gaatccatca atatcgcaat 503041 cgcggacgtg atcggaaaag gcattccagc ggctttatgc atgtccatga ttaaatacgc 503101 aatggactct ttgccggaaa cgggcataca cccttctcaa gtgctgaaaa atttgaatcg 503161 tgttgttgaa caaaacgttg atgccagtat gtttattacg atgttttatg cgaattacaa 503221 tatggacaag catcaattta catatgcttc agcgggacat gaaccgggat tctattattc 503281 tcaaaaagac aacacgtttt acgatttaga ggccaaagga ctcgttctcg gcatctcgca 503341 ggactatgac tacaaacaat tcgatcagca tctggaaaag ggcgatatga ttgttttatt 503401 ttctgacggc gtcacagaat gcagaacgga aaacggtttc ttggagcgtc ctgatctgca 503461 gaagctcatt gaggaacata tgtgttcctc tgcgcaggaa atggtcaaaa acatttatga 503521 cagcctcctc aaattgcagg attttcagct tcacgatgat tttacgttaa ttgttttgcg 503581 gagaaaggtt taacgtctgt cagacgaggg tataaagcaa ctagtgattt gaaggaaaat 503641 ttgaggtgat acgaatgaat ataaatgttg atgtgaagca aaacgagaat gatatacaag 503701 taaacattgc aggagaaatt gatgtatact cagccccggt gcttagagag aagctcgttc 503761 ctctggcaga acaaggagct gacttaagaa tttgcctgaa agatgtcagc tacatggaca 503821 gtaccggatt gggcgttttt gtagggacct ttaaaatggt gaaaaaacaa ggtggttcgc 503881 tgaaacttga aaatctttct gaacggctga tccgactgtt tgacattaca ggcttgaagg 503941 acatcattga tatttctgca aagtcagaag gtggagtgca atgaagaata atgctgatta 504001 catcgaaatg aaagtgccgg cccaacctga atatgtggga attataagac tgacgctgtc 504061 aggggtcgca agcagaatgg gctatacgta cgatgaaatt gaagacttga aaatcgcagt 504121 cagtgaggcg tgcacaaatg cggttcagca cgcttacaaa gaagataaaa atggggaagt 504181 gtcaatacga ttcggtgtgt ttgaagaccg tttagaggtt attgtggcgg atgaaggaga 504241 cagctttgac tttgatcaaa agcagcagga tctagggccg tacacacctt cgcacacagt 504301 tgatcaatta tcagaaggag ggctcggtct atatttaatg gaaacgctca tggatgaagt 504361 cagagtgcaa aaccactccg gcgtcaccgt agcgatgaca aagtatttaa atggggagcg 504421 agttgatcat gacacaacca tcaaaaacta cgaaactaac taaagatgaa gtcgatcggc 504481 tcataagcga ttaccaaaca aagcaagatg aacaagcgca ggaaacgctt gtgcgggtgt 504541 atacaaatct ggttgacatg cttgcgaaaa aatactcaaa aggcaaaagc ttccacgagg 504601 atctccgcca ggtcggcatg atcgggctgc taggcgcgat taagcgatac gatcctgttg 504661 tcggcaaatc gtttgaagct tttgcaatcc cgacaatcat cggtgaaatt aaacgtttcc 504721 tcagagataa aacatggagc gttcatgtgc cgagacgaat taaagaactc ggtccaagaa 504781 tcaaaatggc ggttgatcag ctgaccactg aaacacaaag atcgccgaaa gtcgaagaga 504841 ttgccgaatt cctcgatgtt tctgaagaag aggttcttga aacgatggaa atgggcaaaa 504901 gctatcaagc cttatccgtt gaccacagca ttgaagcgga ttcggacgga agcactgtca 504961 cgattcttga tatcgtcgga tcacaggagg acggatatga gcgggtcaac cagcaattga 505021 tgctgcaaag cgtgcttcat gtcctttcag accgtgagaa acaaatcata gaccttacgt 505081 atattcaaaa caaaagccaa aaagaaactg gggacattct cggtatatct caaatgcacg 505141 tctcgcgctt gcaacgcaaa gctgtgaaga agctcagaga ggccttgatt gaagatccct 505201 cgatggagtt aatgtaatga tccaggttga agaaaacgag catattcaaa ctctagtata 505261 tcaactgaat aaagaaggga aatcgatttg cggtgacagt ttttttatga aagctgatga 505321 taaggagtta atttgcgcgg ttgctgacgg actgggaagt ggatcacttg ctaacgaatc 505381 ctctgcagcc atcaaagact tagtggaaaa ctatgcgagt gaagacgtag aaagcattat 505441 cgaacgctgt aatcaggcga tgaaaaacaa aagaggcgct acagcatcta tcctgaaaat 505501 caattttgag caaaggcagt ttacgtactg ctctgtcgga aatgtacggt ttattctgca 505561 ttccccgtct ggtgaaagct tttatcctct gccgatttcg ggctatttat caggcaagcc 505621 gcaaaaatac aaaacgcaca ccgccaccta tgaaaagggt tcaaagttca ttatacatac 505681 agatggactc aacgtacctg atatccgctc ccatttgaaa aaaggccaat cggtagaaga 505741 aatatcgaat tcgctgaaaa tgtatacgac atcgagaaaa gatgacctga cctatattct 505801 cggacagctg tcctaaaaaa ccagaaaaag aagctggaca tccggcttct tttttttgcg 505861 gttgactatt aataagtgcg cttattatac ttaataagtg aacttatcat tctgggagct 505921 tatgggatgt ggaattatga atacacagcg atagctgatg tggatgtggg aaaacctgga 505981 actgttatca ggaaacagaa acaatggatc aatgggagac gggtattgca tcagattctt 506041 tgaaaggaca atttcaaaat ggaacggaag gaacattgct tctgcaagga aaaacaattc 506101 tcttatggct tgagcatgtg gagaaacatc gggcgttttc tgtcatggtc aacatgcccg 506161 catagcaatg taataatgga gttttttcac gtgcttcaaa agcaaaaaga agatttgtgt 506221 atcacatatg gaattgtatt agaaggcgct gaagcaaaaa agtggggaga aatcattggg 506281 actgaactgt ctaaagacat gccgacggct gtcagcaggc ttgtccatct ttacggagga 506341 gtgataaaat gaacacaaat tactggatcg gcgttgtgtc agagcaacat gtattaaaag 506401 gcgctgccgg cggttttgca cagctgtgcc atggaaaaaa agccccgctc gccaaaatga 506461 aagagggaga ttggctgatt tattattctc cgagagacgc atatccagac ggcaaactgc 506521 tgcgaagctt tactgcgatc ggcaaagtaa aaagcggaaa catctatccg tatcaaatgg 506581 ctccgaattt tattccatac cgattagata tagactatta tccatgccat aaaatcggtt 506641 tttacgacat taaatcaaag cttgaatttg ttcaggaaac caagcatctt ggctttttat 506701 ttcgcagagg acactttgaa ataagcaaaa aagatttttt gacaatagca caagcgatgg 506761 gagttaacat aagtggaatg gcactctaaa tttagcggtc cgaacacaag cccgggcttt 506821 ttattatggc aggccacgca aagttggcag cggaaagtag gaaaagcatt ggctgagttt 506881 gacctgaccc acgttcaatt tgttctgctg acctcgtgca agtatatgat tgctcacgga 506941 gaaaccgtca cgcaaaaaaa acttgcaagc ttcagccaga ccaatatcat gatggtttcg 507001 gaggttgtgc ggacgcttga gaaaaaagga tttatcgaaa gaagcaaaaa tccccaggat 507061 aaaagagagg tcctcctgtc tcttacagaa ataggaggag aaaaagtaac agcggctttg 507121 ccaattgttg agaagattga tcaagccttc tttgcagctg cgatgaaaaa agagaatttt 507181 ctgagcggct tacaggaact attgaaacat gagtaaagat acgggcagcg ccagctgtct 507241 ttttttatgt gtttttttcg gtttttgata cactagagaa agaacgacaa aattggaggc 507301 tttggttaca tggaaacgtc agccctttta aaacagcaaa ttgcgaaaga aataggttta 507361 tcacaaaaac acgttgaaag tgtcatccgc ctgcttgagg acggcaatac agtcccgttt 507421 attgcccggt atcgaaaaga gcagacgggt tcaatggatg aggttcagat tcagacgatt 507481 tctgaacgct ggcaatacat acaaaacctg aatcagcgaa aagaagaagt catcaggctg 507541 attgcagagc aggataaact gacagataat ctaaaacgta aaatcgagca atcggtgaag 507601 cttcaggaag tggaagacct ttaccgccct tataaacaaa aacgtaaaac aaaggcgaca 507661 gtcgccaaaa gcaaaggcct tgagccgctt gccgactata tcctgacact tccccaagat 507721 gatcatctgg cagcaactgc agaccaatac atcagcgaag aaaaagaagt gttcacacga 507781 gaagaagcga ttgaaggcgc caagcacatt attgcggaac aaatctcaga cgagccgacc 507841 ttcagaaagt ggattcgcca ggaaaccttc aaaagaggaa ccattaagtc tgcagccgga 507901 aagtcggcag acaccgatga gaaaaatgtg tatgaaatgt attacgagta tgaagagcca 507961 attgcaaaag ttgttccgca tagggtgctg gcaatgaacc gcggcgaaaa agaagacatt 508021 ttaaaggtag cgatcgaacc gcctgcggat cacattaagg cgtatttaga aaaacaaatc 508081 atcaaaaatc gctcaacatc cgtaagagag attttgcagg agacaattga agacagctat 508141 aaaaggctga tccagccggc aatcgagcgt gaaatcagga aagagctctc agaaaaagct 508201 gatgaacagg cgattcatat tttctcagag aacttgagaa agcttctttt gcagccgccg 508261 atgaaaggca aaaccgttct cggtgttgac ccagcctttc gaactggctg taagctcgct 508321 gtgtcagatg agaccggaaa agtcttgaaa attgatgtga tctatccgca tgcgccagtc 508381 aacaaaacaa aagaagccca tgaaaaagtg aaaaagattc ttgagcagta tcaagtcgag 508441 atggtggcga tcggaaacgg cacagcatcc agagaaacag agcaattcat cgtcaatgta 508501 ctcagagaca tgccgcgcaa aatttattat gtgatcgtca atgaagcggg agcaagcgtc 508561 tattcggctt cagagcttgc cagagaagaa ttccctgacc ttaaggttga agagcgcagt 508621 gccgtatcta ttgctcggag acttcaagac ccgctcgcgg agctcgttaa gatcgatccg 508681 aagtctgttg gtgtcggaca gtatcagcat gacgtcagcc aaaaacgctt aaatgaatct 508741 ctgcggtttg tcgtcgaaac tgtcgtaaac caggttggag taaacgtcaa cacagcctcc 508801 gccgcgctgc ttcaatatgt agctggatta tcgaagtctg tagcaggcaa cgttgtcaaa 508861 aaacgtgagg aaatcggaaa gttttcaaat cgaaaagaac tgaaggacat cccaaggtta 508921 ggtgcgaaaa cctatgagca atgtatcggt ttcttaagag tgcaggaagg gacagagcct 508981 ttggatagaa caggcatcca cccggaaagc tataaagaaa caaaagcact tttgaaaaaa 509041 ctcggacttt caacagaaca tatcggcacg gcggaattga aggacaaaat caatcagctg 509101 gcgctctctg aaacggcaaa agagctggga atcggcgaaa tcactctgaa agacatttgt 509161 gaacagctga caaggccgga acgcgatcca cgcgataagg tgcctaagcc tttgctgaaa 509221 acagacgtcc ttcagctgga agatttgaaa gagggaatgg aactgcaggg caccgtgcgc 509281 aatgtagtgg acttcggagc gtttgttgat atcggagtca aacaagacgg gcttgtgcat 509341 atctcaaaat tgagcaatca attcgtcaag catcctcttg atgtcgtatc tgtcggcgat 509401 attgtgacag tttgggttga cggcgtagat gtacaaaaag gcagagtatc gctgtctatg 509461 gtaaaataaa agcactgctt acgagcagtg ttttttccta tagaaatacc agcattgatt 509521 cagcagttta atttggtaat tatctttttc aaggaacgct ttttgcatct gctttttaag 509581 ccaatttggc ataggctcat tcctcctcag cttttatcat aagagggaca gtgattacca 509641 tattgtatgc gaacggtgaa ttgtcccgtt caatgttttt taagtgaggt gcaccatgga 509701 taacaaagag cttcaaaagc tgacagagga tatttctgaa acatatttta aaaagccgtt 509761 ccgccatcag gcgcttttta atgaccggct taaaaccact ggcggcaggt acctgttaac 509821 ctcccataac attgaattga acagaaaata tttgattgaa cacggcaggg aggaactgat 509881 tggcatcatc aagcacgagc tctgccatta tcatcttcat cttgaaggaa aagggtacaa 509941 gcacagagac agagatttta gaatgctatt gcagcaggtc aacgcgccga ggttctgtac 510001 accccttaag aaaaaagcgg aaaacaaaaa aacttatatg tatatctgta cgacctgcgg 510061 ccaacagtat ataaagaagc gcgccatgaa ccctgacaga tacagatgcg gaaaatgccg 510121 cggaaaaata aaaagaattt tttcgtgaaa aaggttgacg aatatggcaa gcctatgtta 510181 cattataaaa gtcgtcacga gagataaata aaaacattta cctcttgaca ctgcaaatca 510241 aggctgatat aataagtctt gtctcattat tccacagtag ctcagtggta gagctatcgg 510301 ctgttaaccg atcggtcgca ggttcgaatc ctgcctgtgg agccatattg gagaagtact 510361 caagtggctg aagaggcgcc cctgctaagg gtgtaggtcg cgtaagcggc gcgagggttc 510421 aaatccctcc ttctccgcca taagatttcg atataagttc tcaaccatcg gcccgttggt 510481 caagcggtta agacaccgcc ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc 510541 attccatttc gttgggctat agccaagcgg taaggcaacg gactttgact ccgtcatgcg 510601 ttggttcgaa tccagctagc ccagccattt ttatttttga aatctaatag taagagccat 510661 tagctcagtt ggtagagcat ctgactttta atcagagggt cgaaggttcg agtccttcat 510721 ggctcaccat ttgtcttttt gcgggtgtgg cggaattggc agacgcgcta gacttaggat 510781 ctagtgtctt acgacgtggg ggttcgagtc ccttcacccg cactttattt acaaagtgca 510841 cgcaaatctg ttttactagg ttaagagcct actaaaccag cacaacacaa tttaatgatc 510901 acgcggtcgt ggcggaatgg cagacgcgct aggttgaggg cctagtgggt gaataacccg 510961 tggaggttca agtcctctcg gccgcatctc aataatacca agggtttaac cacctttggt 511021 attatttttt tgtgtggaaa atacggctat gggagaagac ttgctcacca aaactcacca 511081 gttacttaaa gtaagtcatc caaacggtcg gcggttcctt ctgtttatta ggaaaaagat 511141 atccgttcat tgtaaaagaa acgaaccatg tcctattcgt tcaaaaaaac taaagggtga 511201 tacatattat acatgattaa tatgtatcac ccttttcttt cttgttcaac aatcgcgctt 511261 gaggagaaca taagctaata caactgactc gatttctaaa gttgctccat tcttttttta 511321 aacaactcat ccacaacctg ttttaaaatc tcgtacgact gaatttcctt gctcaattcg 511381 taaatattag ataacacaat taattcatct gcgtgataca tttgttggaa atcaattagt 511441 tcgcgacgaa ttgtttctcg atcacccatg attgtatacc ccagtcgact gtggagaatt 511501 tctaattcaa actgtgataa cgattctagg aagttttcag tgggtggaat aagcttactt 511561 aaattatttg tataaatatc aatatacacc tgcaaatgac ttgcagaaat aaaagatgcc 511621 tcgtctatag attctgctgc aatcacatta atgcaagcga tcacataagg ttcttgtaaa 511681 taagaagacg gttggaaatt ttctcgataa atagagagcg cttcttccat cgaatggggt 511741 gaaaattgag cgccaaatgc atagggtaaa ccaagctttg cagcaatttc cgctgaatcc 511801 gttgaggatc ctaacacaaa aacaggcaca tgcgttccaa tacccggata agcgcgaacc 511861 tcaccctgta cactcttatc cccgacaaaa cgcaaaatat catttacttc tctttcaaag 511921 aaaaacactc cattatggtt ggaacgacga atcacatcgg ccgttttttg atccgttccg 511981 ggtgcgcgtc ctaatgccaa atctacacga tttggatata atgtttcaag tgttccaaat 512041 tgctccgcta cgattaatgg ggaatgattt ggcaacataa taccccctga acctacgcga 512101 atgtcttttg tatttgctaa tatatgttgt acaattgata cggttgctgc acttgcataa 512161 gcgtcgtgat tatgatgctc tgcaaaccaa atccgtttat agcccatatt atctacagct 512221 ttagctaatg acactgcaga atcaatccct tgtttcattg tttctccttg tcttaatgga 512281 gcaactgata aaacagatat atcaaatttt ttcataattt cacctctaaa ataatgaact 512341 tatacaagat caatggaaaa aacattttga aaaattgttt catattaaat ggtgtccatt 512401 cctctttgat ttgcatgcaa ataaatatat actttctcaa acgatcaata cataggcaaa 512461 ataaagttat ttcacaattt cactttactt ttaaagtttt aagcaaacat aaaaaaatgt 512521 tcagtgaaca aaatatgtaa aatacatctt atttttcaga aaggatacaa gaaaatgatt 512581 gatgaaatag ataaaaaaat acttgatgag ctgtctaaaa atagtcgcct tacaatgaaa 512641 aaattagggg aaaaagtaca tctcactgca ccagcaaccg catcaagagt agtaaagtta 512701 atagacaatg gcataataaa aggatgtagt atcgaagtga atcaagtgaa attaggcttc 512761 tctatacatg cttttcttaa tatttatatc gaaaaaatcc atcatcaacc ctatttagct 512821 tttatagaaa cacaagataa ctatgtaata aacaattata aagttagtgg agacggttgc 512881 tatttgcttg aatgtaaatt tccttcaaac gaggtattag atcaattttt aaatgactta 512941 aataaacatg caaactataa agtgtcgatt gttattggta aatagttaac tttataaaac 513001 ggagatgtgc ggtcatataa catgatatat atgctctaaa aaagccctag gttggatatg 513061 gaatttacca agctggggcc tttttataca ttataataac aagcgcatta ttcatcagac 513121 attaatgaag tattataatg cttttttact tccttaatag acaaataaag ctgatagttt 513181 ccatacttca ataaatcatt cagaaggtga tttaaaactt cttgtgaatg aaccgttacc 513241 ttcagaagat aacatgcatc tcccgaaaca cgatgagctt cgctaatttc attacgagta 513301 gcaataaatt tcaataaatc atcatgcata tatgcattca tgaaaaagaa gacaaaggct 513361 gtaaaagaaa accccatctt caattcatca accacaatcg aatatgcttt aatgataccg 513421 ttatcctcca tttttttgat gcgattgcct accgcttgtc ctgtcatatg aattttttca 513481 ccgatttctt tccattgtat ccgagcattt ttatttaata attggagaat ttgaaaatca 513541 attgaatcaa tttgcatagt aactcctttc acagtgaaaa agttttacaa aatagtattt 513601 catgagacca tcgaaaattc aatggaaatt atatatcctt atacagtata aaaattttaa 513661 gaggtgaaaa aatgacaaca gctttattag tgattgatat tcaaaatgat tactttccaa 513721 atgggaagat ggctttaaca aacccagaga aagcagcaca aaatgcggct aaactacttt 513781 cacactttag aaacacaggc gcacctgtct ttcatgtaca gcatatcaca gaaggtaaca 513841 tcgctcattt tttccatcca aatacagaag gtgtcgaaat tcatgagtca gtacgtccat 513901 tagagaaaga gacagtcatt gtaaaacata tgccgaatag ctttttcaat acagatttaa 513961 atggaaagct acaagaagaa ggggttaaag aattagttgt ttgcggtatg atgtcccata 514021 tgtgtattga tgcaacagtt cgttctgcag ttgaacatgg ttatgtatgc caagtggtag 514081 aagatgcttg cgcaacaaca acattgcaaa ttgaagataa aatcgttcct gctgagcatg 514141 tccattacgc atttatggcc gcattaaatg gtgtctatgc aacagtaaaa accacagagg 514201 catttttaaa ataaaagaat ttcctgcgcg aacataacgt ctttcttttc acaagaaaga 514261 tgattcaaca acttaaaaaa ggatgttcag aaaaatactt ctggacatcc tttattcatt 514321 atcttttatt gtttttcagt atcattattc ccatctgata aaagatcaag atgtcctgtt 514381 tttgatccat agtaagacca tatacaggga ttgtttttgc cataaatata gatattgatg 514441 aaggtttaca taaagcacct aattgcttga tttactttaa tgttagatcc ctcaataact 514501 ccattctctt ctaatttctc tactctagct gtagctgctg ggcatgttaa atgtactctc 514561 tcccagatct ttcattgaat tcggctatta tacataattt ctctataatt ttttatctgt 514621 ttgatctatt tgaacgttaa ttcctttcga aaataaagtc aaagagttaa aacacttttt 514681 tttatctatg tattcgaaca ctgctgatat tatacactta actctgtcga tctaagacaa 514741 ataaaaaaag aaagtgagtt gtaaatatga atattacaca aattcgaaat gcaacaattg 514801 ttgtaaaata cgcaaataaa aaatttttga tagatcctat gttagcagag aaaggtacgt 514861 acgctacttt ccctgaaacg atcagacaag atttatttaa tcctttggtg agtttgccaa 514921 catcaattga taacattctg gatggcgtag atgcggtaat tgttactcat ctacacctag 514981 atcactttga tgatgtggca aaaaacgtat tgccaaaaaa catcaaaatg tttgttcaaa 515041 atgaagcaga tgcaaaagaa gtaaaagcaa gtggtttcaa aaatgtagaa gtgctacatc 515101 aagacactgt ttttgaaggg atccaattag taaaaacaaa aggtgaacat ggcagagggg 515161 aagagttatt aaacttaatg ggtgatgttt gtggattagt attcaagcac ccaagtgaaa 515221 aagttttata tgtagctggg gatacagttt ggtatgatgc tatcgaagac gagattcata 515281 cacatcaacc agaaatcatt gtggttaatg gtggagacaa tcaaagatta gatttaggtt 515341 cactcatcat gggaaaagaa gacatctatg aagttcacaa ggctgctcct catgctaaga 515401 ttatatctgt tcatatggaa gctgttaacc attggacact atctagagaa gaattaaaaa 515461 actttagtaa agaaaaagga ttctcaagta atattttagt gccagaagat ggcgagtctt 515521 acacatttta atatgaacac cgacaaataa atagaagaag ctcataatta taaaaactaa 515581 tcatgagctt cttctaataa tgaatatttt aaattttaaa tatatcgaaa atcctaaata 515641 tacggaataa caaaaatgga atgttccaat gatgacaaaa aaacttgaaa agcaacaaag 515701 atgtgtcgtt aggaggtaga attcatggta atgacaaaaa aagatacaaa tatatcaaca 515761 cagcagcctc tttggttaca aggttatatt gattcaccag aaaaacaaaa ccaactttat 515821 aaaaaaacat taaaaatctt gattttttca caaatatttg ggggagcagg acttggagct 515881 gggataacag ttggggcgct tcttgcacaa gatatgatag gatcggaaaa tgtagcagga 515941 attccaactg ccctctttac ttttggatct gccgtagctg ccctgcttat aggagcatcc 516001 tcacaacgtt ttggtcgcag agctggactt gcaggtggtt tccttatagg cggattaggt 516061 gctataggtg tgataatcgc ggctttaatt aacagcgttg ccctattatt tgtttctctt 516121 cttatttatg gagcaggtat ggcttctaat cttcaagttc ggtatgctgg gacagacctt 516181 gcaaatgaga aacaacgggc aactgctgca agtatggcct tagtttctac tactttagga 516241 gctgtagtag gtcctaactt agttaataca atgggggaat ttgcagattc aattggtgtt 516301 cccaatttag ctggtccgtt tattatgtca ggagcagctt ttataattgc tggaattatt 516361 ctcttaattt ttcttcgtcc agatccgctg tttgtatcaa cagctattgc gaatgctgag 516421 aaaaaagacg ataaagtaca aataggagga agtctaaaaa atcctgctat agacaaaaaa 516481 ggaataatgg taggagctgt cattatgatt ttagctcaac taatcatgac agctattatg 516541 acaatgacac cggttcacat gggtcatcac ggtcatggtt taagcgaagt gggattagtt 516601 ataggactcc atattgcagc gatgtatctt ccttcaccat tgactggttt attagtagat 516661 aagtttggtc gcacaactat ggctattgct tcaggtgcca cacttcttgc cgctgggttg 516721 gtggcagcta ttgcaccggc agactcatta tcattgctaa tcctagcact agtattacta 516781 ggggtaggtt ggaactttgg tttactaacg ggaactgccc ttattataga ttcaacacat 516841 ccatctctac gtgcaaaaac acagggaaca ttcgatgttt tattagcact atcaggagca 516901 gcaggtggag ccttgtcagg aatggttgtt gcacattcta gttatacaat actatcaatt 516961 tctggagccg ttttatcatt gttactcatt ccagtagtta tttggtattt tagaaggatt 517021 caggaaaaag cataagctta tataactgtc tttgaagaac ctaagtagac attactttac 517081 cggaacctcc tttttctatt tattatagta aggagttgac atggcattag tggcatgtgt 517141 ataactacac aattatttgg gattcagaga gcatgtaatg aacggaagag ataattattt 517201 atcactttta ttattgtacg gtgttcttgt ggcattaagt tcagtcaatt ttggtctaac 517261 tgttttcttt ttgttttcat cacctctcca tattattaac aaacacgaaa aggattttaa 517321 tgaaaataaa atgattagcg tatgtatctc taattttcaa aatgaatgaa tagtcctttt 517381 taagatttac acacttattc tccaaggaaa aatgactcaa tttttcgatt ttttatgtaa 517441 atcaaaaaag aatcatgtta gagtaggtgt gctgaaaata attcaaaaaa ttattttgcg 517501 atatgattaa agtaatattg ccagagagtt tcaattggac aaaattgtaa gtgtttaata 517561 cactggggct gcaatcaaat atgcacctgg aatcaattgc taaacggggg agtttatatg 517621 aacaacaaga aaaatatctt tgatattgtt atgtacatta ttttcggtgt gttaagtctt 517681 tttctagttg caaaaactga ttatggcact ggagttttag tgtttgttgc aattttatac 517741 ctcgctgtta ttgcttataa aattaagcaa gtatttagta attcagattc ttaaggtgta 517801 acacaaggag gatttcaatt gagaaagaaa agagttatta cttgtgttat ggctgcatca 517861 ttgactttag gctcactttt acctgcaggt tacgcttctg caaaggagga ctctaagaca 517921 accccttctt acgaagaact agctctacat tacaaaatga aaagtgaaaa gatttcatcg 517981 aacgggaaat tagttgaaat tgagtatgtg agtggaaatg aaactcacaa agttcagatg 518041 aacggaaata atcatactgt aaaagtcgat ggcatagaac aaaaaggttt aaactttgag 518101 tatgatgaaa atgttgctaa aagaacaaat tatgaaaaca ataatttgaa atcaaatgaa 518161 ttcacaacac aggctgcaaa acctaaaaag ggataccatt atgtggggac tttatctggg 518221 catacaaaag cagctaaaaa tgcgttatca gttacaatgt cattagtcgg tattgtccct 518281 ggcttgggat gggggagtaa ggctgccact attttattct cttattgggc aaaagaacaa 518341 atccctgatg cgtattataa atatgattta tacgaaaaag gagcaatgac tgatagttgg 518401 tatcagtatg ctacagttca attttttgaa gataaagctc ataaaaagaa aatgggcaaa 518461 ccttggacaa gtactcctgc aaaagtagat ttacctaata gctaatttta aaatcacttt 518521 gtctttataa aggacaaagt gattttttgt tatacagaag taaaatccct cgtctgagga 518581 atcttggaaa aaacttggtt caattttgat ataacatgtt tttttcttgc taatttagtt 518641 tttctatgta tcgctacaca ttctaaataa taagatatta gccggacggt tgatgccaag 518701 ctcaaaagtt tatatggaag tcaaagcata aaaaagggtg ttacaacgtg tagtcttctt 518761 tttattttgc caacgtaaca agtgtgaaag taatgatttg taggatcagt taagaaaggt 518821 ttaagattag atattgaaaa attttatata ttttcaataa aatactggta ctataataaa 518881 tgtatacaga ttgtatggag atgtaattaa ttaaaaagga gttttttaat tgcgttggag 518941 taaatggttc aatgtttttt gtatagtagc attgggatca atatatggtt ataaattatt 519001 tactaaccaa gaagtcagta ctactcgttt aataatagct tctgtaattg tgttgtggaa 519061 tattgttgga ctttttagca aagaatcagt aaaacaagca cagcaagcaa attaaaagtc 519121 ataaagttgg gaaagaagga tgttacttat gtagtatcct tctttattat tccttgaaaa 519181 atgaaacaaa ttggagatta cagcttatat aatcaattga agtcgttgat tattttcatg 519241 aacaggagat ttaatgcttt ctgatgaaat attatcgtat gaatgttgca agaggaaacg 519301 ttactcaaag attacaggga tgtgatgaac actcctcttt atcgcactca cctgacccca 519361 aattgttggg gaagggcagg tacggaagat agagtatttt ttcttcgtaa caaatcgaaa 519421 aggttggata ataaaaaact tataatctaa ggcggtatat agttgtgaaa aaggcgttat 519481 ttcttatatt agaccagtat gcagattggg aaggtgttta cttagcatct gcattaaatc 519541 aaagagaaga ttggtcggtt cacactgttt ctttagaccc tattgtaagc tcaataggtg 519601 gttttaaaac atctgtcgat tacataatag ggttagaacc tgcaaatttt aatttgctag 519661 ttatgattgg cggggattcc tggagtaatg acaataaaaa actattacat tttgtaaaaa 519721 ctgcatttca aaaaaacatt ccaatagcag cgatatgcgg tgcagtggat tttttggcga 519781 agaatggttt gctgaataat catagccata caggtaattt tgtttactta tggaaagatt 519841 acaaacaata taaaccgatt agcagttttg tagagaaaca agcagtaaga gataaaaatt 519901 tggttactgc taatggaact gcccctattg aatttactaa tttaatttta gagatgattg 519961 attttgatac tcctgagaac atagagaaaa tgatgtatat gaatcgttat ggtttttatc 520021 atttttgtga taaatatgga aatccatttg ttgattaatt tgctggaaat gattttcccg 520081 aatagggggc tttgcgattg agttgaattt cctaataaag caaagaaaga tgatttgagg 520141 tcaagtttaa caaataatgc catcaatatt aatttgcagt tatttccgat tcctgatata 520201 ataaagaaga attatttttg ttcggtgtaa aggatagtat gaagattgac ttttcgtctt 520261 gatgatactt tgggcaagga tagtatatac tgtgtggtta cacactagga ggcaacaaaa 520321 atggaacaag gtacagttaa atggtttaat gcagaaaaag gttttggctt tatcgaacgc 520381 gaaaatggag acgatgtatt cgtacacttt tctgcaatcc aaagtgacgg attcaaatct 520441 ttagacgaag gtcaaaaagt atcgtttgac gttgagcaag gtgctcgtgg agctcaagct 520501 gctaacgttc aaaaagctta atcttcaatc gtttatacaa acaggctctt tatatagggc 520561 ctgttttttt atgtctatat catactcaat aaaaaaccct actcaacgtt cgagtaggga 520621 gatgctacaa ggtaatagaa aaagatttaa aacttcaaag gtttgtttac agtataacat 520681 actggattga caatatgcgg aatgtatata aattatttaa tgttttgttc aaatatagat 520741 aactgactct ttttttcact aacctgttcg ttcatttaag taagattaga tgaattataa 520801 aaatggtttc atctaaatgt tatcaactcg catatctctt ttatgagaag aagataaaca 520861 attattattc aatgttgcag tggatataag aaattcttaa aaataatgag gagatcgatt 520921 gtttttttct cctggaaata atcacttaga gatacctaaa acaatgaaag ccctacctct 520981 cttccatcct tacggctcct tgtccgtgcc agtgtgaatc aggatactaa aaaaagtgac 521041 tattttattg agttttttgg taaaacttca atcttcgcag aagaaatgta aataataaaa 521101 atggattaga atgtaggaat aacaaaagag gtcgttaatg ttctaaacat aagttggaga 521161 agatttgctt ttcatcataa tattccgaaa tatcttttgg gatgtatcta accaaaactt 521221 tttatttgtt tttcagtgat tcctttaatt acttccagtt cactaatcaa aaattcatat 521281 gcattatcca gcattttttt ttcgcttgca ttaagtgctt tttctttctt catacgcatt 521341 aaatcacgta caacttcagc accttcttgt atttcacctg tttttatttt gtccgtgttt 521401 attttgtacc tttgcttcca tggcagtaac ctatcggatt ctccatgctg aaaaatgtgc 521461 ataatgtgtt ttaatgcaag tatatcggta actggtcgta tattcgaact caatatttta 521521 ctcgttggaa tcataactgt catattactg attgacattc ttatgacata atactgttgt 521581 ttttcctcta agaattcttt ttcttctatg gcttcaatta tacctgctcc gtgcattgga 521641 taaacaatgt tatcgccaat ttgaaacata tcatccacct ccatatatgg tatccttctt 521701 aagattacca tatatggagg tgtaatatca aaattttaat aataacatga tcgaattttt 521761 gatgtcaata acttttttga aaaaacagat caagcaaaaa caatagggaa cgtgtcggat 521821 ttccaatcag gaaaaggtca attgatccgt gtgagcagtt tttcattggc tcaatgacat 521881 tacagaaatg atttgagtag ataagaaaga acgatattcg tgaaatgtca gctaaaaata 521941 tttaaagcac atgattaagt tctaatttct ttaccgattt gatatggata acggccgact 522001 tacttaatga tgcattttca cttatcttgc aagcagaaaa aggtttgttg ataaacattt 522061 agccaccaaa ttggcattat tatcagggaa attgacaacc ttcaaatggg tattgaggcg 522121 agaagaaaaa taaagaaagg agagattata aatgaagacc agaacataaa gaagtaaagg 522181 ggaaagaaca aggttaattg aaaagcaaac tatataaaat agtttgcttt tttttgttat 522241 gacttcactt ctttttcttt ctctttaatg actaataaaa caccgctcag aattaaaaac 522301 gaacctatcc aaaatgtccc gcctatttgt tctccaagca gaatccatcc gagtaaggtt 522361 ccaaccagag gctgaaaaaa gaaaaagagg cctccacttg aggcatttaa taattgtaag 522421 ccgtggttcc acaataaaaa tgcacaagct gttgaaacaa ttcccaaata caaaaggcca 522481 cctagaattt tagggtcaag cagtagtggc gtaaaaatcg tgctagggga gtaccattaa 522541 cagggactcc atttattaat agaataaact ttatgaattc atttttttgt atgataatgg 522601 cgtcatattc atcgcttgtt gaaatttact tatgaaataa ctggtactgt taaatccaac 522661 ttgataagac acttctgtca cattggattc agggtgttgc agtaataata agcttttttg 522721 aattctataa tccattacat aacgtaatgg cgtcttattc agcattcgtt taaaataacg 522781 gcagcattca gaacggctca gttggccagc ttttgcaatg tcctctaatg tgattttttc 522841 aacataatgg agatggatcc agtttaacat ttgtttcatt cgatgacttt ttatcatttc 522901 agattgatcg tactctaatt gaaaaccatt aacgaccagg tttttccaca ttaacgttaa 522961 ttgcatcgta atgtcaatct catagagcga tgtcttttgt tgaatcaatt gatttatttt 523021 tttaacagca tctagaatat tttttgccca ctgttgattt ccagccaaaa ataaataggg 523081 caaattggtt gaaaacatat agggctgaac atagcttgaa tacagttcct gagataaaac 523141 gaaatggggt gacacattca agcaaatata cgtacaatcc gagccttcct tttcttcggc 523201 catgtgcagg tagccgctat tgataaataa tccatcccct tcgtgaacct ctattttttc 523261 ttcatttatt tgaaagagag ctatcccttt tagtatcaaa acaaattgga tttcatcatg 523321 ccaatgaagc ggaatatagc catttatatt ttgattgatc gttgtcttgt agcaggcaac 523381 tggcaattct accgttcggt gctctgttaa ttcttttaaa ttttgatcga tcacaaaatt 523441 cttcattctg acttcacacc tcaatatatt tatatttttt cattcaattt gagtattttt 523501 tatcatgttt tgcatttatt ataacactat tattatattt attagtgagg agtcatgtat 523561 gaatacttcc aatagaagaa tgggattgtt ctatgttatc acaggggcga catgttgggg 523621 gattggaggc acagtagcca aaaaactttt tcaagaatat caaattgatg tcaattggct 523681 tgtaacgaca cgcttgctta cggctggaat gttactttta atgctgcaac tgttcagaaa 523741 ggatcgttcc caggttattg aggtgtggaa acacaaagcg tcggctggcc agcttctaat 523801 ttttggccta ttgggaatgc tagctgtgca gtacacatat atggcatcca ttcaacatgg 523861 gaatgctgcc gttgctacgt tattgcaata tttatcccca gtaatcgtca ttatctacac 523921 gctgttgcga aaacaaacgg ttcttaccaa acaagatatc ataactgttg tacttgcttt 523981 agtgggttgc ttttttttgt taacaaatgg ttcaatgtct caactttcag tgccggcagc 524041 tgcagtagta tggggagttt tatcaggatt cgcggcagct ttttatactt tgtatgccgt 524101 tggtttatta aataaatttg attctcttgt cgttgtaggt tgggctatga ttattggcgg 524161 ttttgcattg ggttttatcc atccgccatg gcaactggat tttcaacgat taactgctga 524221 ggcgtatgca tatatcttat tcgtgatatt atttggaaca atgattgcgt tctggttctt 524281 cataaaaagc ttggaaagcc tctctccaaa agaaacaagc ctactaggca gtctagagcc 524341 tctatcagct gttgtaacaa ctgtcgtttg gttaaaagcg ccatttggtt cttttcaatg 524401 gattggtgct atttgtatta tagggataac tttaatattg gctttacata aagagccttc 524461 tatggagagt gaaaaatcga tattaaagat taggaatcat gcaaatcggg atatataggg 524521 gctttttttg cttacatgac cggtccggca atgaaaaaca ctggtggagt ttgagccctc 524581 tcggcagtat caaaaatacc aagggttttg acgccctagg tattttttct tcaagaacct 524641 tcaatttttc ttctctgatt gaaaaacgta ttactttttt gtgattggta tccaaatttc 524701 acttttaaaa gatggtgatg ttacatcctt atgctcgttc cacaatattt ctggaccttc 524761 tatttgttcg taatttgacg atggaaacca ttcggaataa atgcgtcccc atacttcttg 524821 cagtgtatcc ggaaatggcc cgattgattc gaatacagcc catgttgagg caggaacttc 524881 aagccgtgag aagttatctg gacaccgttt cgttgtggct gcgccaatat agtgatcgag 524941 ctctccgttt tcctctgtcc gaccttcaga aaaattcgtg gatgcactaa tgaggcctga 525001 tggtgctaca ttagatagct cttttagttt atttattgct ttttcatcta aactttccca 525061 catagatgca atttccggat taattccttt gaaaataata ggaactcttt ttttaatgcc 525121 aacgatgcga aatgcctctt tttcttcaat acggtagttc atttcatttc ctcctttaat 525181 tgttagctgg aaggtcattc gtggataagc tttaagggaa tggccattaa atctggcttt 525241 tgatgggttt atgccatgta aattttggaa tgcccgtgca aaagaatctg gtgagttata 525301 accgtacttt attgcaatat caatcacttt tacattgctg tctttcagtt caaaagctgc 525361 aagagtaaga cgtctgcgac gaatatattc cgataatgaa atacctgcaa ggaaggaaaa 525421 catcctttta aaatgatatt cagagcagaa agcaagcttt gctgcctctt gaaaatcaat 525481 atcattagtg aggttttctt caatatactt taacgcccta ttcatacttt taagcaaatc 525541 catttatttg gcctccttta accaaagaat aacaggagtg aaatgtattt atccgacatt 525601 ctgtgcacag ttttgcagga tgacttatat gaaataaagt aagtgattca cttgtatttg 525661 tacaggtttt attgaagcat gctgttcata aaaaggcatc aataaaagaa agttataatt 525721 gtcttataaa cggcacattc atataattga gtgaaaaagg atgcgtatca tgcctatcaa 525781 ttcttttgaa aattatccga tgagctggaa gccatcgatt gataaagctg aaaagcctat 525841 ttataaagca cttgcagggc aattggaaca ggatatttta aacggagttt tattacctgg 525901 aacaaaactt cctccacagc gagaattggc cgattatcta gatttaaatg tgagtacgat 525961 ttcaaaagca tttaaagtgt gtgagttaaa agggctgctg agtgcgactg tagggagcgg 526021 cacatttgta tcgtatgatg cgttgtcgaa tgcgtattta cttgaggata ctaagccgac 526081 acatttaatt gaaatgggag caatacttcc agatcacgct tcatatgagc ccttgttata 526141 ccaactgaaa aacatggttc atgaggagga ttatgaaaaa tggtttagct atggccgggc 526201 aggtgaaagc ctttggcaaa aagatgcagc tgtaaagctc atccaaagag gcggatttga 526261 aacatccgtt gatcacattt tatttgcaaa tggagggcaa aatgcgattg cagcgacatt 526321 ggcgagtctt tgtaagcctg gagatcgcat cggagttgac catcatacgt accctggatt 526381 aaaaactgtt gcatcattgc ttagtgtgca aatcgtaccg ataaaatcag aaaacgatga 526441 aatgagtccg gagtcacttg aatatgcgtg taaaaacgaa aatattaaag gtttgtattt 526501 aatcccggat tatcataatc cgacgacttc ctttatgtct gttgagaatc gaagaatggt 526561 tgcagacatt gtaaagaaat ataatctgtt tgttattgag gatgcatcgt accatcttct 526621 caacaaaaat ccgcttccgg cactcgcctc attcgcaccg caacaggtta ttcatattgc 526681 aagtttatca aaatcgttag cgccaggcct gcgtttggct tatgtagcag tgccgagaca 526741 atataaggag ccaatatcaa aggcgcttta taatttaaat ataactgttt ccccgctatt 526801 agctgaactt actgctcgca cgattgtatc aaatcaattt gaagtcttaa ttgagagtca 526861 tcgtgaacaa accattcgca gaaatcaact cgtaaaccga tatgttgcgg gatatacatg 526921 tttaggtgtt gaaacaggca tttttcgttg gttgttgtta ccgggtaaaa tgtctggtgc 526981 cgaatttgaa gaattggctg ctcgacttgg cgtgcaagtg tatgcggctg aacgctttgt 527041 agtgggaaat agttgtcctg aaagggctgt aagggtttct gtctgtgcac caaaaacact 527101 tgaagagctt gaacaaggat taatgatcct gagacgtttg ctagacgatc ttacctaata 527161 ttgtttgcca tacaattatg acattgtatg gcttttttgt gcgtgttatg atgatccaca 527221 tctagaggga ggtttataca aaattggctt ttagaaagga aggtcagatg atgttagaca 527281 aggacagcgt aaaagcaata gatgttcaaa ctgcttcatt acagagctac atcagttcac 527341 cagaaaaaca aaaatcgtta tacaagcgta cactattcgt tgtgagtatc tcacaaattt 527401 ttggcggtgc ggggctggcg gcaggagtga ctgtcggtgc gcttattgca cagcaaatgc 527461 ttggcactga tgcgtttgct ggtttgcctt ctgctttatt tactttaggg tcagcaggat 527521 ctgcattaat tgttggaaga ctttctcaac gttatggccg tcgaacaggt ctttcagctg 527581 gctttatgat tggcggactt ggagcaatag gcgttattat ggcagcaatc ataaatagta 527641 ttttcttgtt atttatttcg ttgcttattt acggtgcagg tacagccact aatttacagg 527701 cccgttatgc aggtacagac ttagcaaatc ataagcagcg agcgactgct gttagtataa 527761 ccatggtttt tactacattt ggcgcagtgg caggtccaag cttagtgaat gtgatggggg 527821 atttcgctct ttctattggt gttccatcac ttgctggccc tttcatttta gccgcagcag 527881 catatatgtt agcaggtgtg gtccttttca ttatgcttcg tccagatcca ttagttatag 527941 caagaacaat agaagcggca aatgaagagc ctggtgataa aggacatttg gcggcaactg 528001 agcatacaga aaacaaaaaa gggataatcg ttggggcaac ggttatggtt cttacccaaa 528061 tagtaatggt agctattatg acaatgacac cggttcatat gagacatcat gggcatgact 528121 tgggtgcagt cggtcttgtt attggttttc atataggtgc tatgtatctc ccttcacttg 528181 ttacaggtgt tcttgtagat aggttgggac gtaccgcaat ggctatttcc tctggaacaa 528241 cgttgctttt ggcaggtgta atagcagcat ttgctccggg agaatctatg attcttctcg 528301 tcattgctct ttctttactg ggattagggt ggaattttgg tttgataagc gggactgccc 528361 ttattgtaga ttcaactgat actgccacac gagctaaaac gcaggggaca gtggatgttc 528421 tgattgcgtt gtcaggagct gctggcggag cattatctgg aatgattgtg gcaggttcaa 528481 gttacctcgc attatcactt attggaggga ttttgtcctt attactcatt ccggtggtgg 528541 tatggtctag gggccgctaa agggtaggat tgtttaattt acattaattt gttatattgt 528601 tagataaagt atattgcagc atctaatatt ctaacgaact atagttgctc cattaaatct 528661 attataaaga tttgaccagg attccttata gctgtgtcac tcactgcata ttctttaatt 528721 gaatcacata aaatggttat cggatttgaa aaaggcagga ttactcgctt taggtaaagg 528781 agtcataacg ttgttaaaaa ggttttctct tgttattgtt acactaatga tgtctatcgt 528841 tgttgtttta gcggctgcta aagagtcgcc tggagatcat gtcatctcat ttgatgaacc 528901 tattatcttg atgatctcaa ttggaatcgt tgtattttta ttgatccctc cattagtcat 528961 gtcctttttt ggcaatttgg ttgtaagaat aatatctggt gtataccaat gttttatcgt 529021 tttcactttt ctggggctca ttccaattgg atttcttatt cccaatggct ttttgacaat 529081 tctagtttct attgcaggaa ctttagtcag tatagctagt gttgccgtaa ccttatgcat 529141 tggcaagaat aaaaaagata tataatcatc gaattgttat tttttcagat tgtcagtgaa 529201 ataattatac aaaaagagaa ggcttgtggg ccttcttttt ttgttgttgc atcatcccca 529261 ctttgagctt aatctattga ataataagag aaggaaccta tagaagaata aaataaatac 529321 cgagatgtca aaaataaaac tggacttcat tattgtgaat tcacgtaaat gtaaaaagat 529381 tggaaagagg ggaattcctt catgacaaat agcagaacaa atccgaaggt tgatgaattt 529441 ttaagtaaag cgaaaaagtg gaaggaagaa tttgagaagt tgagaaccat cattcttgac 529501 tgtgagctga ctgaagattt taagtggatg catccttgtt acacatatca taataaaaat 529561 attgttttaa tacatgggtt taaagaatat tgcgcgcttc tgttccacaa aggcgtctta 529621 ttacaggata cagatggaat tctcattcaa caaacggaga atgtacaggc ggcgcgccag 529681 attcggttta caaatgttca ggaaataaat gagctagaaa acattttgaa agcctatatt 529741 cacgaagcca ttgaagttga aaaagccggt ttgaaagtgg atgttaacaa aaatattgaa 529801 ttgaacattc ctgaagaact tcaaaataaa ttcgatgaaa tccctgcatt gaaaattgct 529861 tttgaagctt tgaccccggg acggcaaaga gcgtacactc tttatttttc tcaagccaaa 529921 caatccaaaa cccgagaatc gagagtcgaa aaatatgtgc aaaaaattct cgatggaaag 529981 ggattaaagg attaggcacg ccaaggttca ggctaaagga atagcatcat agcgtaataa 530041 gatcatttct atagaagaaa aacaagcata gtaagatgct tgttttttct taggacaaca 530101 ttcacttact gctgaaatgc ttctaacatt gtatgccact agacagcgtt ataaaatatt 530161 aatgcaacac ctagaaatct atccaatgaa atagctcaat ggtatggctc attacattta 530221 gaatgcctag gagaactaat agaaccggaa gatttttagc aagttactac actccaaact 530281 ttgtttttgt attaatatac cttattaacc attgttttta gtcaggtgca gacaaacgaa 530341 tactgattaa tgaatcatca tgatatcaat gagccgcttg attttttcat cgtcgcctgt 530401 atcaacgtac actgtttttc tgttttttat gatactctca gtcacttccc gcatgacgcc 530461 tttttctata tcatcagcgg aatcccagcg taaaggcaca ttatatacat gaattgtgcc 530521 atccccattg ccatgataag tgactgatcc atccactaaa cgagaacctg ccaactgggt 530581 cacattttct ggatagctgg cacttgtatc atcattagga ttaattggct cgccagccgc 530641 aatatgtcga acatttaatt catctatctc ttgattaggt ccaagttgaa gccaaactct 530701 ggcatattca attttttccg aagagtatgc tgccaataca ttgtcttctt tgcttttctc 530761 ttctgctgaa gaggtatcat ttgcagcttt tgttgcggat tcttctgatt ctgttattgg 530821 ctccgcttca tccttgcgta ttttggtgct ctcttcaggc tcagtgtgtt tttcgtcagt 530881 ttgcacagca gaagcttgat ttgaaggttg ttgtgcttct ccatccttac tgtccgtaca 530941 tccagcaagc aaaatcataa gcagcagggc agtattgcaa taacatatct ttctgcgttt 531001 cttcattttt tcattcctct ctattaattc aggtcagctt catatataag tttatgtatc 531061 taaatattac catggaatag ataggatgat attgaaaact gtttaagaag aggaaacgat 531121 cttgaatagc atcgcgaaaa cctaagaatc ttaagaagtt ttgccccttt ttcttcaggt 531181 attgaatgta aagtgggata taaatgcaaa caaaaacgaa atgccttatc cacctcgtgt 531241 catggcagaa aaagtggggg atttattaga gcggatttga taatggcggc aggtaaatgg 531301 gtgttgactt atatgtctaa gcgggagact caagtctgct cgatcgcata caaaatacca 531361 agggccagca acccttggta tttttatacc ttcatgcatt tttgaagttt atgcttaaag 531421 gtctgcctta ctttgcaaat cgccgagctg ctgcaacgca catgataacg gcgatattca 531481 ctgctacgag tgcccagccc actttctcgt gcagaatcac tgaggcaagc agcagtccaa 531541 aaaaaggctg gagaagctgg agctgcccaa ccgctgcaat tcccccttgg gcaagacctc 531601 gataccagaa cacgaagcca atcagcatgc tgaataagga tacatatgca agactgagca 531661 gtgcgggaac gccgatcgcc gaccatgagt ccggcgtaaa aaagaacgac aatggcagca 531721 taagaggaag cgacagaacg agtgcccatg agatcacctg ccaattcccc agacgccgtg 531781 aaagtttggc cccttctgca taaccaagac cgcatacgac aatagaagcc agcatgtacg 531841 cgtcgccaag cggggatgaa cctcccccct gaatgagggc gaaacctgct actaacaagc 531901 tgccggcagc tgagaaaatc cagaagacgg ggcgagggcg ttcacccccg cgcagtacgc 531961 cgaagactgc cgttgcgagt ggaagaagtc caatgaagac aatggcgtgt gcggatgtga 532021 catgctgaag cgctaaagct gtcagcaacg ggaaaccaat cactacgccg aacgctacca 532081 ctaacaatga aatgagatct cttttggcag gatgctgctg ccggaagatg agaaggagac 532141 ctcccgccag tacaccagct atcgcagcac ggcaaactgt gagaaataac ggatcgaagt 532201 ctgacacagc caaacgggtc gcaggcagcg agccgctgaa aatgagtacg cctataaaac 532261 catttatcca gccatttgtt gttttgttca ttataatcac tccacatatc tttcttgttc 532321 attgtctgta ttttcttaac aaaaccagca gctaaggatt acaatgacta taaactggaa 532381 ttggcctttt ataaacagcc agttttcata aaaaaatgca taccagttag gagaacaacg 532441 cgcaaatgga tatcacgcct tttttgaata gaactctgga tattccgctt tatcagcagc 532501 tttatcggta ttttaaagaa aatatgcatc ggggccgtat tcaaaaagga atgaagcttc 532561 cttcaaaaag actcctggcg aatcagcttt ccatcagcca aacgactgta gaacgtgcct 532621 atgaacagct cgctgctgaa ggttatattg tgagcaagcc aagaagcggg tggtttgctg 532681 attatcatga ttctgatttt gcttatgata gaatgccaag cacaacaccc attcaacaag 532741 aagcagaaga aaataaacaa tggattgatt ttcattatgg gaatgtagat tcttcttact 532801 tccctttttc cgcatggcga aaaagcatgg tcaatagctt agaccaatat ggacacgagc 532861 tttatcggcc gggacatgtt ttaggagagt ttgagctgag aacactcatt gcagagtacc 532921 tgtatcaatc tcggggggtt cattgcggcc ctgaacaagt gattataggt gccgggaacc 532981 ctattctgct gcaaatcttg tgccaagttt ttgagccgaa tatttctata gggtatgagg 533041 atcctggtta tccaagagca cgcaagattt ttgaagccaa ccgcatgaat attgttccta 533101 taccagtcga tgatgaggga atctgtatac agaagatcaa agaacagcag ccaaaccttg 533161 tatatgtcac accttcccat caatttacgc tgggaaccat aatgacaata aacagaagaa 533221 ttcagctgct caaatgggcg gccgaaaatc aatcctttat catagaggat gattatgacg 533281 gggaatttag gtacacagga cagccggttc cttctctgca agggcttgat cagcataacc 533341 gtgtcattta tatgggcact ttttctaagt ctcttttgcc ctcgctgcgt atcagctata 533401 tgattcttcc ttcgcctctt ttaaaaaagg gtcatgaaat cacgtcctta tataagcaga 533461 cagtgtcctg ccacagtcag ctaaccctag ctgaatttat aaaaaatgga gagtggcaaa 533521 aacacatcaa cagaatgaga aaactttacc gcaaaaaaag agccattgta ttagaggcag 533581 tgcaaaggga attaggagag catgtcagaa tccgcggaga aaactctggg cttcgtatct 533641 tacttgacgt ttatttgcca tttggtgaaa aagagttaat tgagaaggcg aaaaaacatg 533701 gagtaaaaat ttatcctgtt tctctttctt atcaacatca tcctcctaca aaaacggtct 533761 cgctcgggtt tgcaggggtt tctgaatccg acataagaga aggcataaaa aaactgaagg 533821 ctgcctggaa gatatgaggg agctttcagt ttagcaaaac ggccaagtga cgactaagtg 533881 ttgagagctg ttcaatattt tttaagtata tgatgagtgc ctgcagtcca ggccacgata 533941 cgtctgttta gcgaaaaaca gaatttttta tttgctcctc acagtgctaa aataaacaaa 534001 atagacaatt gaaaaaatag aggtgtaaga atgaagttag atgagtttac aattggccag 534061 gtcttcaaaa cgaaatcatt aaaagtatca aaagatgata ttatgcggtt tgcgggtgaa 534121 tttgaccctc agtatatgca tgtagatgaa gaaaaagcga gtaaaggcag atttaatgga 534181 attatcgctt ccggcataca aacactggcc atatctttta aactttggat tgaagaaggt 534241 ttctatggag acgatattat agccggaaca gagatgaatc atatgacatt cataaaaccc 534301 gtatatccgg atgatgaatt gtttacaatt gttgaggttc ttgataagca gccaaagaga 534361 aatgaattgg gaatactcac agtattgcta tctacttata atcaaaaaga agtaaaagtg 534421 tttgaaggtg agttatctgt attgatcaaa cgataactca gaaagcccgc ttttcgcggg 534481 ctcgattgaa gcagatgggt gaaagatgtt agcgggtttc ctttgaaaaa taagaggtta 534541 aaacatcata aacaataggc aaagaagtaa atccctcatc ttctagaaaa tgacctccgt 534601 gctgaacttc atataacgca gcatcaattt gttgtgccag atccttgctg aatgaaaaag 534661 gcacaatttg gtcgtcctta gaagcaatga cagcacggtg cttcgcggac tcgatgattt 534721 tttgatgatc aaacgatccc tgtgtaaatt catctaacat ctgtaaagtg ggcaatgatt 534781 tggcaaagcc ggaaacaagt atgattccgc caagctgttt tcgtaattga agatgttcca 534841 aaaatctcaa aatggcgggg caacctaagc tgtgcgcaac caaatacgta ttttcatgta 534901 aagtgtgctg atataaagag agtgtatcca gccaatcctc aagtcttggc tggagcggat 534961 taggcatgtt taaaatgtct gcttggaccc catctgcgag cagacgtttt ttcagccaag 535021 ggaaccaatg atttgttgag gaggctctgt agccatgaat gatatagact tgttttgtca 535081 ttatttcctc ctaagaaata ttttcattca gtataaaatt cctctcattg ggaaacaagt 535141 acgcactttt ttgtaagtag ctttacatat gaggccctcc ttgtgccatt ccccacttac 535201 acatctcatc tatgagggga tacaaagatc gccctctgtc agataacgaa tactctactt 535261 tcagtggggt gtgagaaacc tcagaccgat gaataaggcc gtcagtttgc aattccttaa 535321 gctgtgcgct taacatttta tgggtgatga agggcatagc ccttttcagc tcgccgtatc 535381 tcatcgtttt ttcacaccct aactcataga gaattctcat tttccatttg ccccctataa 535441 gagataaggt gtattcaaat ggggcttgtt tactgcggca caggctattc attgtaatca 535501 aacctccttt tttaagtatc atatcagaat aaattaggat tttcggtgtt gaagtttgag 535561 ggcgattcac gatctgaagt gaaaggggcc gcttgctcaa caggcggcac ggtacatgaa 535621 tgttctaagt caaagagggt taccttactg ttagttactt tatttaaaaa aacgcatgtt 535681 tttagctgaa aatatctatt atggtatatt taaatataaa gaaatatttg agaaatgagg 535741 aatggtatga atacacccaa aaaacataag aaatttaaag cgaaaatgat tctccaaatc 535801 atcatggtta tcattggagg aatcatagcg gcatatggac tagaaacagt gctcattcca 535861 aacagtgtat ctgatggagg ggtgacgggt cttagcatcg ttggttcaca gctattcaac 535921 ttgccgctgg ggattttgat tgctgtgatc aacattccat ttgtctggtt aggatataag 535981 caaattggga aaagctttgc attattatca attatcggaa tcgtatcgct tgccgcgggg 536041 acaagctttt tccaccacac acccgctatc atagaaggag ataccctgtt aattaccgtt 536101 gtcggcggga ttatccttgg attcggaatg gggctggcgc tgcgtaatgg cggcgcatta 536161 gatggaattg acatgcttgc tgtgctgcta tcccgaaaac tgccattcgg aacgagcgat 536221 ctcattctat tcttaaacct atttgtgttt atttttgttt ccacagtatt tggcttacaa 536281 ggggcattgc tttcagtcat tgcttactac attgcatcca aagtgattca tgttgtggag 536341 gaaggcttaa gcggctctaa aacctttcaa attattacaa cccaacctga attaatggta 536401 gagacaatac gtgatcaatt aggccgaagc gccacatata aagaagctta cgggggtttt 536461 tcccacgaga aatttaaaga aatcacatgt gtcatcaacc gtttagaaga aaccaaacta 536521 aaggaaatta ttaatgatat tgataaaact gcctttgtta ccgtgtatga tgtagctgaa 536581 gtgaagggca gcaattttag aaatcttaat catcactaaa aaatagaatg acctttttaa 536641 ccgtaactga catgccgcgg gtaatttaat caaaaacact tttttgaggc ttgtgggtga 536701 ataaccggtg aaggtctgaa tcacagaaat accaagggcg tcaaaaccct tggtattttt 536761 tctggttatt agattttatc ttcagcttta cgtgctgctt cgagcttatc aatcctgtct 536821 ttatattttt ctccccagtc cttcatgtgc aggataacag gttctaatgt tcttccaaac 536881 tcagttaaag agtattcgac ttttggaggg acctgtttat aaacctcgcg gtgaatcacg 536941 ccatcccgtt ccaattctct taattgtagc gtgagcatac gctgggtaat ttttgggtat 537001 agttttcgaa actcattaaa cctcttttta ccgtcaatga gatgataaag aagaatgcct 537061 ttccacttac ctccgatgat atctaatgtt gtctccaccg gacatccttc aaagtcatca 537121 gaagaataat caatgccgag tttacgattt ctcaagctgt tcactcctaa tagtatactt 537181 tttgatacta tatacattca atgtgcgtac tttttatatt ttaatataca tcatataatg 537241 atgtcacatc taaggaatga aaggaatgga tcatatgaaa acactcgtac tcgttgtaca 537301 tccgaatata gaatcctctc gtatcaataa aaagtggaaa gaagccgttt taagtgaacc 537361 agatgtaact gtccatgatc tttatgaaaa atatcgcgat caaccaattg atgtggaatt 537421 tgaacaacag cagctcctgg cccatgaccg tatcgttttt cagtttccat tatactggta 537481 cagcagccca ccgcttttaa aacagtggtt tgatgaagtg tttacgtttg gctgggctca 537541 tggtcccggc ggaaataaat tgaaggggaa agagtgggta actgccatgt ccatcggttc 537601 acctgaacac tcttatcaag ccggcggata taacttgttt tcgataagcg agctgacaaa 537661 accgttccaa gcatctgccc atttagtagg catgacctat ctgccttcct ttgccgaata 537721 tcgcgccaat acaatcagtg accaagaaat tgccgaaagt gcgaatcggt atgtaaagca 537781 tattacaaat atagaattaa acccgaaggt tcgcctgcaa aggtatttga aacagctgga 537841 gagtgtcgat ttaacataaa gattgatttt tgaaaatcct gtactcacca agcaggattt 537901 tttcttgttc agcagaggga ttttaacata tagcaaaaaa agaagaagcc accaaaaata 537961 agctatttgc ttggtcctga ctgcttattt ttggtgaaat acttatttct ctgtgatgaa 538021 ataaagcaaa gcgatgaccg gaaaagcgat tccaatccat aatgctgtac tccatccgcc 538081 tgaggcatat gcccatcctc caattgatga ccctatcgca ccgcctagaa agaagatcgc 538141 catgaataat ccgtttaatc gactgcgaat ttcaggcgcc aacgaaaaaa tagcacgttg 538201 actgagcaca aggtttgcag atacacccat atctaacaga atagcagcgg ccactagaac 538261 tgttataccg acgggggagc tgctctgaat catgagcggc agtaataaag agacaacgac 538321 aacaccgaga gcgattccag tggcaagcct ggttaagcct cgatcagcca ggcggccgcc 538381 tattggtgca gtgactgcac ccgcaatgcc caccaatgcg tagagtgcta ttgccttctg 538441 agaaaaatga aaatcaggac cggacaataa taaaggaaca gttgtccaga acaagctgaa 538501 agctccaaat acaaacgcat gatagatggc acggcggcgt aagactggag tcgtgcgcag 538561 cagcttccac attgaaccga gtaaggcagt atagtttgta tttgctgttg gttttctggc 538621 aggaagcact tttgataata cgatggccag gataacactt accacggcgg acaaagcgaa 538681 tattgcattc cacccccaga tatcagcgac tagactagat atcggacggg aaagcataat 538741 accgagtaat aagccgctca tgacattgcc aacaacccgg ccgcgtgcag cgtctgatgc 538801 aaggtatgat gcaaatggaa caagcacttg ggctgcgatt gatcccaatc cgacgaaaaa 538861 cgcagctgct aaaaacagtg ttccatgctt cacaaatgct gttagtgtca aagccgctgc 538921 gcttagaagg agcgatacaa caataagttt tttgttttcg ataatatctc ctaaagggac 538981 aaggaatagt aagccggcaa cgtatccgat ttgggtgagt gtgacaatca atccagcacc 539041 gcttggagaa agtccaattg ccttactaat taatccgacc aagggttgtg catagtaaag 539101 attagcaaca atgataccgc atgcagttgc gagaagaagg gttaaactgg gtgaaatcct 539161 ctgacctgct tgtttgtttc cattagccat atgaatgaac tcctttttaa gtggtttttt 539221 gagtgtaatc atgacttctc acaagtgatt ttataaactg aacgttcagt ttcgtcgatt 539281 aataaaaata atatactaaa cgttcagttt tgtaaatgga tttctgtttt ctttttttat 539341 tcaatttaag tatactgaac gtatagttta tattgcggga aggaatgatt tatgtgcaga 539401 gtaaacgagg gcggccgcgt gatgaaggaa cgcataaggc gattctctct gcagcctatg 539461 acctattgct ggaaaaaggc ttcgatgcgg tgacagtcga taaaattgcc gagcgtgcga 539521 aagtgagtaa agcaacgatt tataaatggt ggtctaacaa ggctgccgtt atcatggaca 539581 gctttctttc gaccgcgacg gacaggctgc ctgtgcctga tacagggtcg tcagtacaag 539641 atatagtaac ccacgccacg aatttagcta ggtttttgac aagccgggaa ggaaccgtta 539701 ttaaggaatt aataggtgca gggcagttgg atgaaaaatt ggcagaagaa tatcgcacgc 539761 gatttttcca gcctcgccgc ctccaagcga aaggccttct agaaaaggga attcagaaag 539821 gtgaattgag agagaatctt gatattgaag taagcataga tctcatttac ggaccaattt 539881 tctatcgtct gcttataaca ggggatgagg tgaatgattc ctatgtgcgt gatttggtga 539941 tgaatgcgtt taagggagtt caagctacct ctgctacaga gagtatgtag ctgataagaa 540001 ctgcaaaagc tgcggattat atgacaaatt ggttccatcg tacagtgaaa tataagattt 540061 ttgttgctga gcggaatcat cgagggaaaa gttctcttat cggatgtcga aaaagaagtc 540121 attcaatcgt gaatacataa catcatatta ttacattcct tttcatcgat tggaacaagg 540181 gttctatact tcaatggaat accgcaaagt tggagtattt aaacaacagg ggaaaatcga 540241 tggccattat gtaggtgtca tggcaatgga aaaaatactt gcaatgtaaa caggcctcta 540301 aagagacctg ttttttaata tccagatgat tgtctagttt cagcttgggc tctatgacca 540361 ctcccataac tgaaatagtc taatatttat accagaaggg attgtttata taaataaaag 540421 tttatataat gacgggggcg ctaaggaaac gcggggagcg actcaggttt tcgtttcaaa 540481 gttttgatcc ttaagatata cggagcgcta catatggaaa cgtaaagggg aatgtataat 540541 catttggcgt gtatataacg atttgcttat atattgattt gggaaggagg agctcatatg 540601 acgattgatg ttgcggcgat gactcgttgt ttgaaaacac ttagtgatca aactaggctt 540661 atcatgatga gattatttct tgaacaagaa tattgtgtct gtcaattggt tgatatgttc 540721 gaaatgagcc agcccgccat aagccagcat ttgcggaaat taaaaaacgc aggttttgtg 540781 aatgaggaca gaagaggcca atggcgttat tattcaataa atggttcctg tcctgagttt 540841 gatacattgc aattgatctt acatcaaatt gatcaagagg atgaattgtt aaaccatatc 540901 aaacaaaaga aaactcaagc gtgttgccag taaggaggca ttagattgac atcaatgatt 540961 ttggcagtat tcatcttttt attaactcta gtattggtca tatggcagcc gaaaaattta 541021 tctatagggt ggtcagcctg tggaggcgca gttttagctc taatagcagg tgttgtcaat 541081 tttcatgatg tgttaactgt gacagggatt gtttggaatg cgaccttggc ttttgtggcc 541141 atcatactga tatcgttaat tcttgataat atcggtttct ttgaatgggc agcgcttcat 541201 atggctaagg ctgcaaaagg atacggtgtg cggatgttcg tttatgtatc tctattagga 541261 gctatcgtcg ccgcgttatt tgcaaatgac ggtgcagctc ttatattgac accaatcgta 541321 ttagcgatgg tcagagcatt acattttaat gaaaaattag tttttccttt tatcattgcc 541381 agcggattta ttgcggatac cacttcgctt ccttttgtag taagcaattt ggtcaacatt 541441 gtttcagcgg actattttca tattacgttt attgattatg catccagaat ggttgtcccg 541501 tacctgtttt cgctgctggc gagcatcatt gtactttacc ttttctttag aaaaagcata 541561 ccaaaacgct atgatctgac tgaggttaaa aaacctgttg aagcaattaa agatcaaaac 541621 atgttcagac tgtcatggta tatcttaggg ctgctgttaa ttggatattt tgcaagtgaa 541681 tttttttcta tccctgtatc agtggtagcg ggcagcattg caatcatttt cttaatcgct 541741 gcgcaaaaga gtccggccgt ccatacaaag aaagtggtga aagaggcgcc atgggctatc 541801 gtattctttt caattggcat gtacgttgtt gtgtatggtg tccgaaatgc cggattaacg 541861 gatgtccttt cagatgtgat tcaagccgca gctgatcaag gattgtttgc tgggacaatt 541921 ggaatgggct ttattgcggc gattctttct tccattatga ataacttgcc gactgttatg 541981 attgacgcat tggccattgc cggtacagat acacatggga tgatgagaga agcgcttatt 542041 tatgcaaatg tgatcggttc agatttaggg cctaaaataa caccgattgg ttccttagcg 542101 acattattat ggcttcatgt tctttcgcac aaaggtatga agatttcctg gggcacgtat 542161 tttaaaacag gaattatcct cacgataccc actttattga tcacacttgt cggcctgtat 542221 atttggctgc tgataatcca ttcttgtttc taaaaggaca aggtcactat atcaaggaaa 542281 acaatgcact ggtaactctt gccgcagcca aatggctgaa gggtggggga gaaaatacct 542341 tggggctaag tggaatgtgt acagcgcagg aatcgaagct caaggatgac atcgagtgct 542401 gtcaaagcaa tgaaagaagc agggattgat atttcaaatc aaacatcgga gaaatttgat 542461 gatccggcaa aagcacacgg aacagaagaa gtgtttccaa agggtccgtg atgaaattgg 542521 tgaccgttta aaacagtttg ctgtaactgg ggaataaaga atcgatatat tcagcgtttt 542581 cttgggttat ataatacaat gtgttgttca acaggtgtct gcgagctgag tgcagacacc 542641 tgtttttgtt tttatttgtc tgagattcgt aacagggaag ttatttagct ggtgacagag 542701 gaaaattgat ttgtgaacag aatcatgaag gagacggtgt tttaaaggag ttgtctgttt 542761 tgcaggaatt aacaaaaaaa aaatacagta gcttaaaaac aatgtttgat gacaaatatt 542821 gtcccacatt tgtctattca atattagacc aaaccattcc gggagctgtt tatgcagatg 542881 atcaaacctt tcctaaatcg ttttttatag gaactgaatc aggcatttat tttattgcgg 542941 gagaccaagg gaatcgggat tttcatgatt tcattgcagg atattatgaa gaacaagtga 543001 aatcatcaaa acgatttacc ttgttttctt ccagtgatac atgggatagc gtactgaaac 543061 ccatactgaa agatgactta aaccaaatga gaagagctgc attttcttat caaccaaaat 543121 ctttcaaaaa gactttgcaa ctgccaaagg ggcttgtatt gaaaagaatt gacgaagaca 543181 tcatttcaca tagcacagcg tttaacagcg cgtattatga ggagtattgg aattctgtct 543241 cacagtttgc ttcaaaaggt tttggatttg ccgtattaca tggcaatcac gtagtaagtg 543301 agtgtacctc tatattttta gggcataatc gagcggaaat ggatatctat acacttgaag 543361 aatatagagg actggggtta gcttattgcg tagcaaatag gtttatagcg ttttgtatgg 543421 aaaatgggat tgttcctagc tgggattgtg atatttgcaa caattcgtcc attgcattag 543481 cagctaaact agggtttaag acggtaacgg aatacactat ttactactct ggctaacctt 543541 aatgaaagaa ccttaaaagg agataccaac cgatgttggt atcttttttg ttttagagtt 543601 tttttaccct tttagcagaa aaatgggtga tgaaaatctt attcatttta tttactttta 543661 ggtaggtaaa acataccccg ccaactgtaa ccactccgcc tagcagagag agcagtgtgg 543721 gtatctcgcc gatccagagc caagatatga tcaaggctaa agccggtgta acataaagtg 543781 aaagggttgc ttctgaagca ccgacgaatg aagtgacata tgctagtgcg aagtaaggaa 543841 taaccgtcgg caataatcct aagtaaacga tagacaaagt tgcgcttatt gaagcgttca 543901 tcatctcttc gcctaagcct ggcagaaaca caagcatagg tattgttccg ccccaaatgg 543961 tgaatgtaac gaatggaata aaaccatatt tttttatata gcgggcttga aaaacgaaat 544021 aaatactctc cgaaaatgct gccagcagga tgaccaagat accgctcatt gaatatgtaa 544081 agtctcccgc cccaaatgca atcaataata cacccaataa actgatcata gagccaagcc 544141 atttcgtaaa tccaaaatgc tctttataaa acaggcggga tagcatggct gagaagatcg 544201 gtgccgtagt aacgagtaag cttgcaactc cggcactaac tgttttttca ccgatgttca 544261 gcaaaatgtg atagaatgca aatcctaaaa accctaaaag aaaaatggca ggaatgtctt 544321 tcaagtcggg taggcgcatc tgagtcaaaa cagcaaaaag caataatgcc atagagccga 544381 ttaacaaacg aaataaagca aggtgttctg gcgtgtaccc ttcaagtcct gcgcgaattc 544441 ccggaaaagc agatgcccat aaaccaatca tgagactatg agatatcatt atttgaactg 544501 ttttctttcg cattcctctc actcctcttt acaaaaacca accagttatt taatgtgttt 544561 ctatactaat aaagatttga tgatatggct tcaaccagtt caatagattt tgacccaacc 544621 aatttatttt aaggagaccg attctatgag ctttccagaa gaaaaaaaga tgaaaaagct 544681 ccctaagtac agacaaatcg ttcattttat taaagagaaa ataggaaatg gagagtggcc 544741 gattggaagc aagattccaa gccagcgcac gcttgcaaaa gattttcagg taaatcggag 544801 cacagtgatt acagcgttag aggaattgat ggccgatggg ctaatagaag gcacaatggg 544861 gaaaggcaca gttgttatca acaacacatg gacactgatg gctaagaatt ctgctcccga 544921 ttgggatcaa tatgtcacct ctggcattca gatgccaagc cgaaaaatcg ttcaagagat 544981 aaatcaatca gaatcaaata cagaccttat acagctcagt aaaggtgaac tttcagctga 545041 gatttttcct ttggctgtta tgaaagagat gatggggaag gtatctcaac acatggaggc 545101 attcggatat gaagaaccaa aaggttactt acctttgagg gaggcattaa gcaactattt 545161 aaaaaccatt ggaatcaacg tctcatcttc ttccattctg attgtctcag gagcgttgca 545221 agccttgcag ctgatatcaa tggggctgtt acaaagagga tcaaccgttt atcttgatca 545281 gccctcctac ctttattcat tacacgtatt tcaatcagct ggtatgaagc tgactggact 545341 tcctatggat aatgaaggac ttttgcctga aaatgttcat ttaacaagag gagagcgggg 545401 aagggctatc ttatatacaa atccatgttt tcacaatccg actggtattc ttatgtctaa 545461 aaagcgacgg gaagaaatcc tagcagtaag tgagaataca cagcttccta ttattgaaga 545521 tgacatttat cgtgagttat ggatcgatga aattccgcca tatcctatta aaacaattga 545581 taaaaatgga cacgtactgt acataggaag tttatcgaaa acattaagcc caggtttgag 545641 gattggatgg atcgtcggac cggaaccggt gattgaacgt ttatctgaca ttaaaatgca 545701 aacagattac ggatccagtt cgctatccca gagagtagcg gcagagtggt ttacttccgg 545761 ccactaccag cagcatgtag aaaaggttag gcagcaatta aaggtgagaa gagaattggc 545821 cttgagtgct ttagaaactc atttgaaaga agtggcgaca tggaatatcc caaaaggagg 545881 gttttttgtc tggataaaaa tattgccttc catatcaatg aaattacttt atactaaagc 545941 cttatcaaaa gggattctga tcaatctcgg cagtatctat gctcaggaaa aagggaatta 546001 tattcgctta tcatatgctt atgcatctct tgaagacctt caaaagggga tttatgagtt 546061 gggtttaatg attaaagaat tggcaagcag gtaactttta tatccttaaa tggatgtttc 546121 actaaaaaag agatcaagcc taatgatcgc ttgatctgat aataacaagg gttactagaa 546181 tagaccaaat catggttcgg tcttaaaata atcatgtctc tgaacgaaaa gtctttccga 546241 cttctcttcc taaaccaaag tagtgtctga aattatagat aagcgggctc catttggaag 546301 ggttgatatg gttttcgtcc agaatgatac tttcctcggc atgaaaatgt agtgcctgcg 546361 tctctacaat tgcgaatgac gattcatatt ctggaagccg aatgtgtttc acttcggctt 546421 cgatttggat agggcattct ttaattcgtg ttggtgatac tgtttttgat tgtaaaggcg 546481 ttaaccctgc tgcctcgtat ttttcttttt tatatgtaaa tccgatctgc ttctttaaag 546541 gcggtatact cttttttccg ctataagatg aaattctttc aacgttttcc cataaatccg 546601 ggccaggcaa gtttatgaca cactctttgt gtctttccaa attgtcgatg gcttttcctc 546661 ccagtcctac tccaaggatt atataatgtc caagagccca agaagaagac ataggactaa 546721 tattagtggt tccatcctca ttcaatgtgg ttagaagaaa tgtcgaggta ccataataca 546781 tgatcttggg tttgatttcc ttaaatcgac gagtgtcttg ttttttgatg tccaacgttt 546841 tttcctcctt gtcacgctta catttatatt gtaaaggatt aacatttcaa ctatcatcga 546901 aatatgaatg taaggaggaa aatcatgaat cctaatattg caaaaatctc ttcgttgcta 546961 tcagatccct cgcgttcttc cattcttctc agtctgatgg atggaaggat acaccctgcg 547021 ggagagcttg catatctcgc taacattaaa cctcaaactg caagttttca cctgaataaa 547081 ttgcttgaag caaagctgat tagcgtagag aagcatggga gacatcggta ttacagattg 547141 gctgactcag atgctgcaaa tgtgatcgaa caattgcttc atattgcgcc taaagcaaaa 547201 gtcaaatctt taaaagagtc aaaagagaaa aaggacttgc atttcgcccg gacctgttat 547261 gatcatttgg caggttatgt gggcgtgcaa atggcacatt cactagttga gcaggggatg 547321 ttaaaaaaag ttgatttaaa ctttgaggtg acttcagagg gtgctttatt cttttcgaag 547381 ttaggcatca atgaagagca acaacggaat aagaggagag cctttgcccg ctgctgtttg 547441 gattggagtg aacggcagca tcatattgca ggagcattag gaaacgccct attggtgcgc 547501 atgttagaag aagaatggat cgttcgtatg cctaaaacga gagcgattag gattacacaa 547561 agcgggaaaa tcgcgtttga aaagcaccta aacgtgaaga tttaggattt tgaagcggaa 547621 acatcagatg atgaggcacg atatctagga ggagtaagat ttgttctaat cttactcctt 547681 cttcttattt tgaagcagct cgattcccca ttgcaataga gatgcggttc caactgttta 547741 tttgattaat gatcagaaca aggtcaacat attgttcctc atcataatgt tcccgcaccc 547801 gatgatatag ctcatcagga acccttttag atggaatgag cgtgatgtgt tcagatagtt 547861 cgagagccgc tttctcttca ggtgagtaaa aatcacattc attccaagca tgtaaacagt 547921 aaattcgctg ttcagtttct cccattttgc gggcatcgga cgtatgcata tctatgcaga 547981 aggcacagcc gttcatttga gagactctga ttttgattag ttctctcgtc gttcggttaa 548041 ttgaggattg tttcgtgtat ttctccatat ccatcatgat tttcatacct tcaggtgcaa 548101 tctcatagta ggacactctt tgactcataa agcaagactc ctttccatag aatacctaga 548161 ttgtatcccg gtattgatca ttttaccaat gtgcggtttg aatgacagct gtttcagcgt 548221 cttttggaaa gaagcttctt tgaataaaaa taagggtagc cagcaatgat gagtggagct 548281 gctaatgcaa gcagtatcca tgagcctgat tggctgtctc tagtgactct aatgaatata 548341 taagtaccga tcagaaaata taataaagca cctagaaacc aatacatgtt cattcctctt 548401 tttccttgct ttttggttgc gcatttttgt ctgtcatatg gcttaatcga tcagggttct 548461 gattttttaa taccttttcg gtccggattc cttttctctt taatgataaa attgtgagat 548521 caatcgattt caatgatgat cattccttca atgaatagta agttccttat gattttaaag 548581 gtaaatttga aaagataaaa cgtacataga ggcagaacgt tcatgtacgt ttgggcaatg 548641 atcacttgtt ggaaactcta atgtttccct gcacctgata ttgttgtgtt ccttctcttc 548701 ctataaaatg attggataca tgtatgtttg cacgttgaaa tatgggttcg attttcatga 548761 atctctattc ggtgaaacag gtaaaggaag tggataaggt ttgcttataa ggaatccttt 548821 taaagataaa tattactcac atgataggcg ggcattaaac atgcttgcac tcagagtgcc 548881 gggcctggct tttattctca tgatctatat agcctctatc gtgctgcaat ttgtttctgg 548941 gggctggtcc attttattgc tttatgcgtt taccatatta atcgccattt ttgctttgct 549001 tcattggcac tcatatcgct gggttaagaa aagagtgatt ctgtatttcg cggtacaagg 549061 tttgatcacc tttgcacttg ctaatctcat gactggcttc tttatacttg tgattatcgg 549121 cctttatgca tttttaattg gacaaattat aggaatggca gacagaagaa ggacttttct 549181 cattctttat ctattgctgc tgctggtcat aaattcggcg tatcaccttc ataaaggtga 549241 agttttgcat tttattgtta ttgctgcgcc gatcatgatt gtcatcatca cttatgccgc 549301 aacatttttt gcccaagtcg atgaaaaaat aaaagctcaa ttgactcttg aaaggctgga 549361 gctggctcat cagcaggtag aacagctgac gctgcagaac gaaagacagc ggatggcccg 549421 agacttacac gatacgcttg ctcaaggtct tgtcagttta aatatgcagc tggatgcgat 549481 tcatgttcat ctcgccaaag gcaacacaga gagagcgaag gaaatcatac aacaatcgat 549541 gaaaagagtg aaaagcacaa tagctgatgc acgttcagct attgacgatc tccgcagcaa 549601 atcagaagaa atcggtgttt taaaagaaag aattacctcg ctaatggatc attttataga 549661 gtcgacaggc atggcttgtt tattagatta cagattgcat caggtgctgg atgtgcgtac 549721 agctgaaaac tgttattaca tcattggaga atgcatgacg aatgcggcaa agcatgctga 549781 ggcgaaaaca atctggatat ccatttggga tgatgaaaag ggaaggctcc atttaacagt 549841 taaggataac ggcaagggat ttgatgttga aaaaggaaag aaaaagagag gacattatgg 549901 gcttcttggc atacaagaac gcgtcagggc aataaatggc caattcaata tcaagagtac 549961 aaaattgaaa ggaacacaaa ttgagatcac tgtaccaatt cagggagaga tgcaagatga 550021 ataaggtttt aatcgttgat gaccatcttg tcgtgaggga aggtctgaag cttttaattg 550081 aaacgaatga tcaatacacc attataggag aggcggaaaa tggaaaagta gcagtccgtc 550141 ttgcagatga attagaaccg gatatcattc tgatggattt gtatatgccg gagatgagcg 550201 ggttagaggc cattaaacaa ataaaagaaa aacacgatac ccccatcatt attttgacta 550261 catataatga agatcactta atgatcgaag ggattgaatt aggagcgaaa ggatatctgt 550321 taaaagatac gagttcagaa accctttttc acacaatgga tgcagccatc agaggaaatg 550381 tgctattgca gcctgatatc cttaaacgtc tgcaagaaat ccaatttgag cggatgaaaa 550441 agcagcgcaa tgagacgcag ctgacagaaa aggaagtcat tgttctaaaa gcaattgcta 550501 aaggtcttaa aagcaaagcg attgcctttg atttgggcgt ctctgagcga acagtaaagt 550561 ccagattaac gtccatttac aataaattag gcgcgaattc aagaactgag gcagtaacga 550621 ttgccatgca aaaaggtatt ctgacaatag acaactaaac tgcatatttg aaaattgccc 550681 aaacgtacat gcccgaatgt acgttttttt catttcattg tcaactacaa tgagaaagaa 550741 tgtgatcaag caatgtgttg aaaggagatt atcatgtcaa aaatgttata tacattagga 550801 ggatgggttg ctcgcaatcg cataaaagca atatgtgcgt ggatcgttgt gttagttgct 550861 gcgataggcc ttgcagtgac cttgaaacca agtttttctg aggatatgtc catacctgac 550921 acaccttcgg aaaaagcgat ggatgtgatt caaaaagaat ttcctcatgg tcctgataaa 550981 gggagcatac gggttatttt cggtgctggt gatggggaga aacttactgg gaagccagca 551041 aaaaaagcaa tagaagatac gttcaaagaa atcagtaaag atgattctgt tgactcgatt 551101 gcaagtcctt ttgtgacagg gacaatcgcg aaagatggca cagttgccta tgctgatatc 551161 cagtataaat catcagcaga tgatataaag gattactcta tcaaacactt aaaagacagt 551221 ttgaaaatgg ctgatgatga aggattgcaa actgagctaa gcggagatgt accgggagcg 551281 gagatggaga taggcggtgt ctctgaaatt gtcggcatta tcttggcttt tgtcgtttta 551341 gccattacat tcggttcttt attaatagca ggtttgccga ttttaactgc actgattggt 551401 ttaggtgtaa gtattggact ggttttgatt gggacacaag tatttgatat tgcttctgtc 551461 agtctttcat tagccggaat gattggcctt gctgttggta ttgattatgc tttatttatt 551521 tttacgaaac accgccagtt tttaggcgaa ggcatacaaa agaatgaatc aattgcgaga 551581 gccgtgggaa cagcgggaag tgcagtggtt tttgccggac ttactgttat cgttgcactt 551641 tgcggattaa ctgtcgttaa cattcctttt atgtctgcga tggggctgac agcagggctt 551701 agtgtactga tggctgtttt ggcttccatc acacttgtgc ctgcggtctt atcgattgca 551761 gggaagcgga tgattccgaa atcaaacaag aaaatagaaa aacaaagcac tgaaacaaat 551821 gtctggggac gctttgtcac caaaaatcct atcatgctaa gtgtatgcag cattctgatt 551881 ttgatcgtca ttagtatccc atctatgcat ttggaactgg gcttgcctga tgctgggatg 551941 aaagctaagg ataatccgga tcgccgggca tatgacttgc ttgccgaagg ctttggagaa 552001 ggatttaatg gccaattaac aatcgtagcg gatgccacaa atgctacaga aaataaggcg 552061 gaggctttcg cagatgcagt gaaagaaata aagggcttag accatgtagc aagtgtcact 552121 cctgcaatgc ctaataaaga agggaacttt gccatcatta cggtcgttcc tgaaacaggt 552181 ccaaatgatg tcacaacgaa agatttggta catgatgtac gcagtttatc agataaaaac 552241 ggagtagatt tgcttgttac tggatcaact gcagtgaata ttgacatttc agatcgcctg 552301 aatgatgcga taccggtgtt tgctgtactt attgttggct ttgcgtttgt attgctgacc 552361 atcgttttcc gttcgctgct tgtgccgctt gttgctgttg caggtttcat gttgacgatg 552421 acagccactc ttggaatctg tgtatttgtc ttgcaagacg ggaatctcat cgactttttc 552481 aaaatacctg aaaaagggcc gatactcgcg ttcctgccga ttttatcgat tgggattctg 552541 ttcgggttag ccatggatta tcaagtattc cttgtcagca gaatgcgtga agaatatgta 552601 aaaacaaaca atccagtaca agccattcag gctggattaa aacacagtgg tcctgttgtt 552661 acagcagccg gcttgatcat gatcttcgtt tttgcaggat ttatctttgc aggcgaagct 552721 tctattaaag ccaatgggct ggctctttcc tttggtgtac tctttgatgc ctttattgta 552781 agaatgacac tgattccaag tgtcatgaag ctgatgggga atgcagcctg gtatttgccg 552841 aaatggttag acaagattat tccgaatgtg gatatagaag ggcatcaact gacaaaggaa 552901 atacagccgg aaatagatca tgaacaaaag aaacaaatca gtgtgtaata gaaaaagcag 552961 atcttttatg atctgctctt ttgcttatgg tagtatttag aagatgaagt cggcagttaa 553021 aaggagacgc ttatggcgcc atcactcatt ttcgatatgg atggaacttt gtttcatatt 553081 ggcagaagct gcatcatact agcaggcatc ccaggagaag tgacatgatt ttttgacttt 553141 gcattcacta cttgatgcca aggatcttga gaatccttct tgaaaataaa ggattttaca 553201 actgatcata taagaaacct aaagaaacaa gcacacaaaa ccagctgcgg gttttgtcca 553261 agaaaaatag agtccataag agggactcta ttttttgaag tgcccggcta gaagcatatt 553321 gcaggacttt atgaatgcaa atcactatct tataagccct taccgtgaaa tgcctgtttc 553381 tgcattgaaa aaacgcatta cacgttcatt tacgtaagtg ggttgttcca tcgataaaac 553441 atgtccggca tttttaatga cttccgcctc aatatctgga acgaatgaag aggctcggtg 553501 cagggctgag tggggatcat agatgacttc atgttcacca agtaataata ggataggaac 553561 tcttgctgaa cgtaattcct catcggtaaa aacatacgga aatccgtcgg cattaggatt 553621 tggatttctt gatccatcct gccacattac ccctgcctta aactgcttca caaaaatcgg 553681 gtgcagcaca ttctgatcat tcatcatcca atttaagaat gtttcaactc catttgacgc 553741 tgtaaggcca agagcgtatt tgtagaaatc gtgatgaaat ggcaaaaacg tttctgccgg 553801 actcagtata gctgcgcttt ttactctctc aggcatacgt aaaaggaaat tcatcgtatg 553861 gagaccgcca agcgaaagtc cgatcatgtg ggacttttcg atccccagat tgtcaaacac 553921 atcaagaagc caattggcgt aatccgttct tgtaccgctt acattctcag gaatactctt 553981 gtttttatca cctatgatat caactgcata agttctgtat ttactgctcc aatcggcgat 554041 gttgggatac cacatcgtcg agctgaataa tgctccgtgg agtaatacaa gcggcggggc 554101 atcctctggg ccgcttgcaa tcacatgtgt ttgaccaaaa cgagtagata tatagaatga 554161 tttacaacgg accggccaaa gactaaggct ttcattataa gtttgataat agcggatacc 554221 gttgtcactt aattcgggaa tactagatga atggtttgac atacaaatgc ccctcccaat 554281 tttgtttaaa tgaatgtgcc gtttcgtgat ggggaatctg attttgatat aacagacttt 554341 atttacaata taatacagtt gttattagac gtcaaatcca agatgaaaag gaaaaaaacg 554401 attgaaacag attattgaaa atcaatataa cagaatatta acctcctttg tggagccgct 554461 tcattaaaac cgcaatccaa atgcatgaat cacaaaaatc acaacaggag ggatcaggag 554521 ggaaggcagc agattcagtg ttttgaactt cttgattcca agaatgctta gacctgaact 554581 gaggatgagt atgcctccca caattgtgat ttcattaata aggtctgtat tgattgcgct 554641 ctccattact tgtgcaaata aatagatgga gccctgccag gaaaataata caagtgcggc 554701 agccgctatt ccaaaaccaa aagttgaagc gagcacaatg gaggtgatcc catctaacat 554761 cccgtttgtc agaaggtatg tataatctcc atgcaaagcg gcttcaacag ggcctaatat 554821 tgacagcgaa cctatacaaa ataataagac cgcagttgat aagccctctg ctaaattgct 554881 tttagaaaat ttgttcacca gcttgttgaa tcgtaattct aaattgatga tctggcctag 554941 caaacctcca atggctaaac tcacgatgaa tagaatgggg tatttactat caggcaaatg 555001 ctgtgtaatg gcgttgatcc ccagtgcgac cgcagcgaat cccattgcct gcatcaaaat 555061 atcctggtat tcatctttaa tgcctttttt gaatatcccc ccgattatgc ttcctgcaat 555121 gatcatcact gtgttaaaaa tcgttccaaa cataagcttt ctcctccaaa aatcattcct 555181 gcataaaaaa taaaccctct agttagtaga gagtcaaggg agatcaaaac atattcatga 555241 gattatttga tgggcagcag gatttcagtc acgtaattat ctaggttatt cgtaatgcca 555301 taatcaatga gtgtgatttc gattgagtcc cctgctacct cataatgatg ttctttcata 555361 tatgccagta attttttgta gtatggttcg gcttctggat gtgacccttt aaacctaatt 555421 tgcagatatt ctcttgaagg aaagatgatt tctgaagaag ttttttcatt ttcatcttca 555481 agaatcataa atatactgga atatttgtca aactgttttg ctttcacatt tgctgcagaa 555541 atggataaac caatcttgcc tatgaatata tcttcgttta cattcaggtg ggttctcaat 555601 tcagctaacg aatgttcgat atcatggccg agaacatatt catgctgcaa ataggccaca 555661 cgcattgcgg gaagtttgat ttttgaaatt tgatgtaacg gcatgttaac ggcatcttct 555721 atatgtgtga tgcgtcggga gatctttcgt tcaatgcgtt ccaattcttt cttcttgcga 555781 tcaatttcaa cctgctggct ttttagtaaa tgaagaagag tgtttgtatt ttgagagtta 555841 taaaaatcaa gaagcttatt gattggcagg cctagggccc tcaaatactt gatggtatcc 555901 agccgctcaa actgttgggt agaataatat ctatagttcg tttgctcatc tttatattcc 555961 ggtttcaaaa ggccgatttc atcataatac cgaagagcag agattttcac attgaataac 556021 tttgacactt ctccaatcga aaaaaattcc ttcattctaa caacctttct gtcctatgat 556081 tgatatacac acattatata gtacggcgag tactaaaggt aaagtttgca gcataaagaa 556141 aaaactcctt ctaaaaagga gcttttcatt cttcgaaata aggatttaca tggatgagca 556201 cttcttctac atctgaaaac tgtcttttga tttcatttcg aatttcgcgg gcaatgtcgt 556261 gtccctgctt aattgtcaaa tcatgatcca aagataaacg gacatcaagc aatttatagt 556321 ggccatgttc tcgcgcgcgg attctatcaa ttcgttttac ctgatcacat tgaaaaataa 556381 cagctttata ttcctctatc agctcgggat caacactctt ttccatgagc acatcaacag 556441 acggcctgat taattccatt gaaatcttaa aaatgaggta agcaacgatt gcactggcaa 556501 tggcatcggc gtacaacaga taggaccatc cacggctgtt tccgatgata gccaacagga 556561 cgccgataaa agcggcaaga gaggcaacga tatcgccttt atgatcgtac gcaatcgcta 556621 taatcgcttt gctgttccat tttttccctt gctttataga ataacgatat aagatttcct 556681 tagccacgta cgaaatcaga gccgcaaaca atgcgctgta ttggggaacg cttggccctt 556741 taacaaagga cagaatcgct tctatgagga tataaacgga tacgatcact aagataattc 556801 ctacaatcgc ctcactaatg acttcagctt ttccgtgacc aaaaggatgg tcttgatcgg 556861 gcggtttatt ggaaattccg atcactgcca agactgcaat cgaagcaacg acatctgccg 556921 cggaatgtat tccgtctgca aacacggctt cactatcgcc taccagccca aaaaagacct 556981 ttcctgccat taagatcaga ttggcgatca atgcaatcaa agcaactttt ctgcttattt 557041 gttctctttc acttgccatt ttttcctcct ataaaactgc acaaaaaaat aggagtgctc 557101 tatatacgct ctccgtatcc tttcctgtgt aatcactttg tttatcatac caattcaatt 557161 tcgagtgggt ctatagcaac gttgtttcct gtttactaat aaataaggtg acagaaaaaa 557221 agttggagct atgctaaaaa ggtcatacag caaacaaatg agttcttatg taacaacagt 557281 gatgattcgc tattaaaatg ctgccgtcag tgaaaaattt ccacctaatt ttcaaaaacc 557341 tattgacatg agaagatctg tattttacta ttatctcata ttcaagatat tttaatttga 557401 gatatttggt cggaaagatc agcgatcaag cgcaactcta agtgttcaat cgttgtcagt 557461 tcttttacac aatattcaat atgatttttt ataacataat atctcgaatt cgagataaaa 557521 gggagtgtag cgtaatggct gaatttactc atttagtcaa tgaaagacga tctgcaagca 557581 attttctttc aggtcatcca atcacaaaag aagatctcaa tgagatgttt gaattggttg 557641 cattggcacc atcggctttt aatttgcagc atacaaaata tgtgacggtt cttgaccagg 557701 acgtaaagga aaagctgaag caggccgcaa acggacaata taaagtggtt agctcttctg 557761 cggttctctt ggtattaggg gataagcagg catatcaaca agcggccgat atctatgaag 557821 gtttaaaggt attggggata ttaaataagc aagagtatga ccacatggtg caagacaccg 557881 tttcgtttta tgaaaacagg ggagaacaat ttaagagaga tgaggcgata aggaatgctt 557941 cactttctgc gatgatgttt atgctgagtg ctaaggaaaa aggctgggat acctgcccga 558001 tgatcggctt tgatgcggaa gccgtaaaac ggattttgaa catagacgac caatttgagg 558061 ttgtcatgat gattacgatt ggaaaagaaa aaacagagag cagaagaccg cgcggctacc 558121 ggaagcctgt gaatgagttt gttgagtata tgtaaaagga gcggataaaa atggctaaaa 558181 aaacgatggg aattcatcat attacagcga ttgtcggtca ccctcaagag aacacagatt 558241 tttacgcagg agtgcttggg cttcgtttgg tcaagcaaac tgtcaatttt gatgacccag 558301 gtacgtatca tctttatttt gggaatgaag gcgggaagcc gggaacaatc attaccttct 558361 ttccgtgggc cggagcccgc caaggcgtca ttggagacgg tcaagttggc gtgacttcgt 558421 atgtcgtgcc gaaaggggct atggcatttt gggaaaagag actagaaaag ttcaacgttc 558481 cctacaccaa aatcgagcgc tttggggaac aatatgtaga atttgatgat cctcatggac 558541 tgcacttaga aatcgtggaa agagaagaag gagaggctaa tacgtggact ttcggagaag 558601 taacgcccga tgttgccatt aaaggttttg ggggtgcaac cctattatca gagcagcctg 558661 acaaaaccgc tgacctttta gaaaacatca tggggctgga gcgagtcggc aaagaaggag 558721 acttcgttcg ttatcgttcc gccggtgata tcggaaatgt gattgacctt aagttaacgc 558781 ctattggccg cgggcaaatg ggggccggaa cggtgcatca catcgcttgg cgggctaacg 558841 atgatgaaga tcagttagat tggcaaagat atattgcttc ccacggatat ggtgtaactc 558901 ctgttcggga tagaaactac tttaatgcca tttacttcag ggaacacggg gaaatcctgt 558961 ttgaaatcgc aactgatccc ccaggctttg cacatgatga aacacaggaa acaatgggcg 559021 aaaaactgat gctgcctgtg caatatgaac cgcatcgcac acaaattgaa caagggctgc 559081 tgccgtttga agtaagagag ttagattgat ttgacacata aaaaataaag aaacatatat 559141 tcaattgatg attgctggat ggtactgtca gcaaagaatc agataaaatc aaagatgagg 559201 agagatacaa atggaagatg caggactgtt gcttattcgt ataatgattg gtgtggtgtt 559261 tttgttttat ggcacacaaa aattattcgg ctggtttggc ggatacggga ttaaaggaac 559321 cggacaatgg ttcgaatcaa ttggggtgaa accaggaaac gttgcggccg ctctatcagg 559381 tcttggggag ttagtaagcg gaattctatt tattttaggc gtattcctcc cgcttggagc 559441 tgctatcata acaatcatca tgttaggtgc tatcgtaaaa gtccatggag cgaaaggttt 559501 tgcgaatggc gccggaggtt ttgaatataa cctggtgctc attgcagttt ccataggggt 559561 tgcactcatc ggttcaggag cttacgcttt gcatttttaa tacgaaagta tgtaagaaca 559621 gttgctgctt gtcagtaact gttcttttat tttcacattt tcggcaagct tgcaggtact 559681 ctgcaaagca aaaaagcgga tatcataaat ataaatctgt atagtgaatg atacgtattg 559741 atgagcttgg tcatgaaaaa cagacctatt tgaaggagta aatggatgaa agagatgaca 559801 ggattacatt cattagtttc tatagaaaac tttatcaaac agcacaaatt cagttttatt 559861 tatatatcaa ggcctggctg tacagtatgt cacgcagttc tgccccagct cagaatagta 559921 ttggatcagt ttccaaacat caaattgggg catatcaatg ctgacgatgt agcagaggtc 559981 gccggcagat tttcagtttt caccgttcct gtgcttcttt tgttcattga tgggactgag 560041 tttctaagag aagcccgttt tgttcatttt gaacagcttg aacaaaagct gaaaagggtt 560101 tatcgattat atgaaggcga ataaaggaat aaggcaaaaa aagaactcaa atgagttctt 560161 tttttattct tcactaggcg aagaagggtt atcaacctgc ccttgatcac ttgtatcatt 560221 atcacaactt gctgaaataa taattgaatg agaaggagag taatctccta atgtgaaatt 560281 cactccgtaa tttttgctgt tcgcagtatg gctgttttgc aagttttgtc cgatatctgt 560341 attggcgttt tgtgtcattc catttatcgt gagatttgag atgttgattt gagatcgcat 560401 gcttcaaaaa ctcctttcac tcagaagtag ctgtcataaa ggacgctggc agtctattta 560461 cttctatgat attgcgtttt tatatcattg catcaacata atggtaaaaa taatagcgag 560521 tgaatgatca tcttttgaag atgatcaacc tatcagcaga aataaagccg cctgataaag 560581 aggcggcaga tcgttatatg tcatctatga atttgatgta tcgtttttcg tttgcctgaa 560641 ggataagata gtcgttttta atgatgagta ggagcctata gcagcgtagc cataaaacca 560701 gcccataaat acgccagaaa agaggctgtg tcgatggctt atgaaaacag aaatgacaag 560761 gcctgttatt aaggcaactg acggtacaaa agttttgggg attttcaata atattttgag 560821 gatttgggtt atcaatatga tgattggaac agctatcaca gcatcccaaa agttcgtgtg 560881 aataattgga aaagccatac ggcacctcat gaagtgttta tttcttaatt tttacgctaa 560941 aagcttggaa agcagctctt ggatcgcata tgttacattt tgggcttgat tggcggagct 561001 tgtttggctt aaagcattgg attcaaaaac caaacctgta ttactcccac cggaaccctc 561061 tgttgtttta gacacagaga acgggctgat ggaaactgca aatccgttat taaaaacgct 561121 gttcccggat atcgaatgaa tataaactgg gaatttcatc attcatctct cctctctgtt 561181 atgactgttt atacaatatg gtgtgtgagc agcagttgct taaacaaaac ggcaaaaact 561241 ttcagtaaga gacaaaaacc tgcaaaatgc cacaagcgcc ttttgttaat gcagcttttt 561301 agggacgttt tttttatttt ttttgccaac ttcatcaaaa atattctgat tgccagactg 561361 ggcttgtccg tccttattta tgaaatcggg gtgaatgagt tttttcagat ccctgactgt 561421 taaaggcttg gcgtcatcag ttaattctat tcctaattgc ccgtttgcct ctaatgtcgc 561481 aattttgaca tcttgtatag ccgtaacgcc gtgaagcctt agctgcattt caagctggtc 561541 agctgtaagt ctcatcttct ttaagttttc gatatgaagc tgtccgtttt caatgacgat 561601 ttttgctttt ccggttaaca tcttttcaat ggtgttcgat ttcatttgga tccattccat 561661 aacgatgagt gtgcttgtga aaattgccgc tgcaattaat gttttgaaga ggctgtactc 561721 gatgattggc tgaacgataa tagttccgat cgaaatcatg acaaccgttt gagtcgacgt 561781 catttgtgcg attgatttcc ttcctgaaat tctcagcaaa atgaccccgg ctacaatgag 561841 aacaagagat tcccaagtga aattcatgct accacctgac caatgatgaa ttagatttgt 561901 catgggattg gcttttcttc cggccaatcg caatttaata tatccgaaag gcagtcggtt 561961 cattctgtcc tgaaccgaac aatatttttg gtatagatgg atatattaag ccaaacaatg 562021 atagcaacag gagttttttg gccgaaacaa tctgggaagc ggggagcgcc ataacatgat 562081 tgaacttgaa gttgtcatta gaacggttgc cagctttggc ttgctgttaa tcgcagaacg 562141 aattttaggc aaacagacaa tctctcaaat gacgattttt gattttattg cggcgatcac 562201 actaggggcg attgctgccg gattagctta caatacttca ataaaaccgc acaatatggc 562261 catttcgttt agtatttttg tgctaaccat ttttctaatt tcgtttctgt cgataaagaa 562321 caggaagctg aggaaatttt ttgccggaga tccaacagtg ctgattcaaa acgggaagat 562381 acttgaatca aatatgagga aaatgcgtta cacacttgat tatttaaatc agcaattacg 562441 ggaaaaagaa atatttaata tcgaagaagt tctttttgcc attcttgaaa cgaatggtca 562501 gctgactgtg ttaagaaaac cgcaattccg gcatgtgacc aaacaggatt taatgattgc 562561 ggtaaaccaa gaacaaaggc ttccgataga acttattatg gacggagaaa tcattgagaa 562621 taatttaaag cagaatcgtt tgacggaatc ctggcttttg gaagaattgc gaaaaagaga 562681 cataaaggtg aaagagaccg tgtacgcagt gctgctgggt aatggggata tttatgtgga 562741 tcaatataaa gaccatatat cagtccctat ggataaggaa tgaaggaaca atcaatctta 562801 aagcccctta ttgaacgcaa cggtttcaac ttgtcttggg tacgaaatat gcagaagccc 562861 gtttaacagc tgaatctgta acaaatgagt ttcagcggct tcgggaagct gaatgattcg 562921 ctcaatttct ccgtaatacc gttcacgcag cacttccatt tcggctggaa aaacaggcgt 562981 gatcgttcct ttgatcagca gctgggtttt agacagtaaa cggatcgtta attcttcctc 563041 atacacaccg ggcatttcca caatgataaa attatattcc tcatcttgat aaaagtcgta 563101 aacaaacgta gaagcttcgg aatcaaaaaa atgttccggg gctttatatt tgagcacatt 563161 tgtccaaaag tcactttgtt tatattcatt cgtaatctca agccactttc gaattttttc 563221 gaaatccata tgagattctc cttaaatttg atttgaaatc ggcgcagaag ggtttccgat 563281 ttggtcttgg tcactaacgt ctgaatcaat atttccagtg tttaaaagtg aagacgtagg 563341 cgaaagatcc cctaaggaaa agtttgctcc aaaatatttg ctgttcgcag tatggctgtt 563401 gtgcacagtc ggaccgacat ctatatttcc gttttgcgtg acgccgttga tcttaatatt 563461 tgcgatatta atttgatatg gcatagacga aaccccttta atctaaaatt ggcggtggtg 563521 caatcggagg agcattaacg ttggatgtat cagagttgcc gatagatgtc tggtcattta 563581 catcaggatc gtttaagaag ttttccatta cggattctgt aggtgatgta tcaccgaaag 563641 aagagttggt cccttgagat ttttgattgt tggtagggct gttataagca gcttcgccta 563701 ttgtaattga accattgccc gaaatactgt tgatcttcaa ataatatagg ttgattactg 563761 tagacggcat cccatcacac ccttccatct ttctgtacag tacattatgc gccgctgcac 563821 ccaattgttc cttgcattta cgggcaaaac tctatctggc cccggagtga tgctcaatta 563881 tcagtgaatg aaaagccatt gatataggaa tcaatgaatt gattcagtta ttcgaaatgc 563941 atgagacctt ttaataaagg aagctggcaa acaggatcag tttgaaataa ttgacaatga 564001 agctaatgcc atgaaataat actcgtgagt aacattactc gtgggtatta tttttggggt 564061 ggtcctagtt gaaaagtaaa ggagtagaaa gccgaaaacg attacttaaa gctgccgcta 564121 atgaattttc ggttcgggga ttccatgacg cgaaggtaag tgaaattgtg aaaaaagctg 564181 ggttcacgca gccttcattt tacctgtact ttcaaagcaa agaagccatc tttgccgagt 564241 taataaccga ttttcactct cgagtcagaa agctgacaga gtcacttctt ctggaaaacg 564301 gattaaacac ggaggatgtg tcaaaacggg tactgctagc tgtagagact gtttttcaat 564361 ttttggatga ggacaaggat ttaaccaaga tcggcttttt tctcaacccg gaagcaaaac 564421 aaatgaaaaa agacttggcg atggttttga aagagaactt agaagcagaa cagcggcttg 564481 gctattttca ctctgaactg gatatggaaa ctgtcgctga gtgtttggtc ggcatgattg 564541 aacatttaac cgaatcattt ttgttaaccg gaatcaaaga tccggcaagc ctcgcagcag 564601 aggttgtgaa tcttttaatt tacgggatgc ttccgaaagg gaatgatgta agatgatatc 564661 tattatgatg aaagtcagtt tggcagtttt tatgcttgcg ggaggcatca taaaggtaag 564721 ccgcgttccc tttcaagttg agcattggcg gcattatcaa tatccattat ggtttctgac 564781 tgttactggc attcttgaaa tagccggggc acttgctatg acagcgggaa tttggaatcg 564841 gtatgcagca attggagcag gtgttctgtt tgtcgttctc atggcgggag caattcatgc 564901 gcatatgttt cgagcaagac aatctgtcat catggcgata caagcgatga tttgtttgat 564961 tgtttcaatc atgatcatca tggggagtta cacgtaagct tttcactaat gtttaagaac 565021 aagcccattt gcaggaaatc tccttttctt atcgaataat agaaagtcca ggaattaact 565081 gaatcagtaa aatagagctc catttctgtg ttattcgtcc ggcatcagct gggctttttt 565141 tataaaggag gaatacagga tggcattcac tttggaagac atgactgagg aagagttcga 565201 agcctttcgc gggatgtccg tgcaaaattt tgcgaaacaa aacataacgt caggaacttg 565261 gacggaaaaa gaggcatttg agaaatcgga gcaggcatat gagaacatga ttccgaatgg 565321 gcgagacagc agcaatcatt atttttggaa catcacaaat gaccaaggag aaagaatggg 565381 ctggctctgg ctgtatgctg atccattaca tccgcaaaag gaagcgttta tctattcctt 565441 tggattgtat gaagcctttc gcggaaaagg acttgctcaa ttggcgcttc aaacgcttga 565501 tgaaagagca agagagcttg gtgcggaaag gctggctcta catgtatttg cacacaacga 565561 gacagccgtc tatctttatc agaagatggg ctatgccatg accaatatac gtatgcggaa 565621 acagctatgc tgaaaagccg cttacgttac ccaaatacaa catgcctatc tggaagcggt 565681 ggcagggtac tataagtcat cattagaaag attaaggtca tgggaggctt gaacatataa 565741 agaaaaagga caacagctgt tgtccttttc aatgccgctt gaactttctc cctcagtctt 565801 ttttgtcttg atgatccagc tcttttattc gtttcgtaag ctcattgaaa gcctgatcaa 565861 gctccttata ccctttatca tttggcgtca taaaactgag ctttcccagc acttcttgtc 565921 tttctgtctc aagctttaac cgaagctcct cccgctcatt tctttctgaa ggaacgtcgt 565981 ttaactgctt ttcgatgccg ttgtttgaga tgacgagttt actgtttgtt gttttttcga 566041 gaaagtatcg gtcatgtgaa accgccagca atgtgccgct gtattgtgac agtgtttctt 566101 ccagctgttc gcgtgacggc aggtcgagat ggtttgtcgg ctcatctaaa atcagcacgt 566161 ctttttcctc cagaatatat gccatcagct tgatctttac acgctcaccc atactcatat 566221 gcttgatcgg ttcagtccat tgggcggctg taaaacctaa gtgcctcatc agattttgaa 566281 cgtgccccct tgctttgaat gtttcattct caaataactc ttccggtgtt tgttctaaag 566341 gcaaatcaaa cacctcctgc gttaaatagc cgatgtttgc ggacggcgac acccatacac 566401 ttccttctgc tgtttcctgt cccagaatga tgttcagtaa tgtcgttttt ccgctgccat 566461 tggggcctat gatcgcaacc ttttcgccgt gctgaattgt aaagtttgcg tttttaaaga 566521 gagtcctttc tccaaacgct tttgttacat tctgaacttc taaaaaacgt tttcctgttt 566581 tgtgggttgt atcgattgaa aagcggactg tatattctgg ggtaacgggt tccgcctttg 566641 ctttttcaag ctctttttca agccgcttct gcttggattt tatctgggca tccgtacgct 566701 tcgcttttac ccggtgatat tctttaaacc cttccttttt cgtcgattga gcatgggctt 566761 tttccgacca agaagcgagc ccattcattt gtgcttcaat ccgttcaacc attttttgct 566821 gcttttcata ttcacgctgc tgggtgagtc ttttcttctc ccggaacttc atatacccgg 566881 agtaattccc tttgaattca atcagcgtct gatcctcaag cgaccatatt tttgttgcgg 566941 cttcgtctaa aaaatatcga tcgtgagaaa cgagaatcac agtgccgtta taatgtttca 567001 gctgttggat gagaaattgc aagctttttt catcaaggtg gtttgtcggt tcatctaaca 567061 gcagcagatc tgcatcctct gatagtcctt tcgccagccg cgctttcagt ttttcaccgc 567121 cgcttaactg atgaaaatca cgaagaggca catgccattt ctccagtaac ttcttttcgg 567181 caggtgtctg atccgcaaag gaatacgccg cggtttcctg ttcaaccaaa gccagtttta 567241 tatccttccg aaggatttga ccctgtgcag gggctaagtc attgtgaatg aggtgcagca 567301 acgtagattt cccagcgccg tttttgccga taatcccaat gatatctcct tgctgaacac 567361 tggcgtttac atgtttaaaa acagtttgat cctttacttc atagctaacg tttgttaatg 567421 ttacgatctc tttcatccat atccctcgct ttaaagggag aataaaaaaa tcctcccaaa 567481 tgtgttggaa ggattagccg tgcctgtgca tgatcaaata agctattttt tataaatagc 567541 agtgtcgtat atatagaaaa tgggcagact aatcctattt tttgatttga aatattgatt 567601 tcaaacggta aaaataagat tagttaatca ttgtccaccc atcatccctt cttgttttga 567661 ttacaaacac tatagcatac ctttaaattc aaaagcaaag gtcattttca tcaaaaaaac 567721 tcctgctctc atttttgagg caggagtttt gagtcttatt gatgcttcgc ttttctcact 567781 ttataaatca caatcagcaa aataaaccaa accggtgtga caaataagga aacacgagta 567841 tcctgtgcca gtgccagcac aaccagaaca aacgccagga acgcaagaat caggtaattt 567901 gtaaacggat aaagcggaag cttaaacttg tttgttttcg ctaattcagg tcttgttttg 567961 cggtatttca tatggcagat gaccgtaatc ccccaaatgt agataaagca tacggttgaa 568021 atacttgtga tcagggtgaa tacgccttct ggcatgatgt agtttaacgt aacaccgatt 568081 aaaatcacga tagctgaaaa gaataaagca tttctaggca ctttacgctg agtcagtttc 568141 gccattgact caggcgcatt gtgatctttc gccagggaat agaccatacg gcttgtactg 568201 aatacagcgc tgttgcatgc tgaagcagcg gatgtcaaca caacaaagtt gataatactt 568261 gcagccccga cgatgccaac agcgacaaat acttgtacga atgggctttc gctgggattg 568321 atgatatccc aaggatagat gctcataatc acgagaagag ccccgatata aaaaagcagc 568381 acacggacag gaatattgtt gatcgcctta gggattactt tttcagggtt ttctgtttca 568441 ccggccgtaa gcccgacaag ctcaatgccg acaaaagcaa acacaaccat ctggaacgag 568501 aggataaacc cgtgcatgcc attcgggaac aggcctccgt ggctccagag gtttgtgaag 568561 ctggacactc ctgagcttgt ggaaaagcct ttgaaaatca tcacaaggcc aatgacgatt 568621 aacgccaaaa tggcaatgac tttaatcaaa gcgaaccaaa attctaattc tccaaaaagc 568681 ttgactgtcg ccagattcat aatcagtaaa ataataagag cgattaagcc aggcacccat 568741 tgcggcacac ccgggagcca atattgagtg tagagcccga ctgctgtcag atcagccatc 568801 gcaatggaaa tccagcagaa ccaatatgtc cagccggtga taaaagctgc catatcgcct 568861 aggtagtctt gtacaaaatc cacaaaagag tgatagttca agtttgataa cagcagttca 568921 cccagcgatc tcataattaa aaagcaaatg atccctgtga tcatataagc aaataaaatc 568981 gaaggtccgg caaaatgaat cgatttgccc gagccgagaa ataagcctgt cccaatggct 569041 ccgccgatgg cgatgagctg gatatgcctg tttttcaagc ctctctgcaa cgtttgctga 569101 tttatattgt ctttcgtcat gtcgtctgtc actttatgtg ttcctccatt gaaaattgtt 569161 tattgagtca gcaatctatt tttaatgatt attataacac taaaatttct atctttttta 569221 ctaaaaaagg attgatgaaa agaattttaa tgtgatttgg actatttccc gaaaaaagcg 569281 gctccattta gggagccgct tttttatgct ttttcagttt ttgtcataaa caggtagagc 569341 ccgtaatctg tcggtgcgga tgcgtagcct gcctgccgca gcattgctgt gatattgccg 569401 cggtggtatg tcccgtgatt gacaacgtgg ggaagcagtt cggaaacagt tgttttcatg 569461 attccgcttg agggattttg aatctggagt ggcttattga gctgttcttt ttgctgtaaa 569521 aatagtatat agcgctcgga taacctcaga aaaaggtctt ccatttcctc tatttcttta 569581 gcctctgtct gttctttaag ctgttcagct aaagccaacg catcgctcaa ggttttgccg 569641 gaaaacactt caatccagcc gagatcagaa agataaacat gagacaatac atgggatatt 569701 gacggaaaca cgctttgaat ttcttgatgg tatatctctt ttggaagctc ttttaatcgg 569761 ttgaatattt gttgattggc ccagacgtta tattcataca atttgaatgc aaaatctgac 569821 atgttaaaat tccccctttc gtgtgtatag ctttcattat acacgaacat gagttcttat 569881 gtagagtgct cgaaaataaa atttgttgac atatatagtt tagaggaata aactaattga 569941 cattgaacat aaagtttagc ggggtaaact ataatgcgtc tgattagagc tcatttcata 570001 aattcttgtt ttttgcagca cacctgtcga ctcaagaagc aggttatcca gcaggtcagt 570061 aattaagttt ccgtggttat acacccacga cccgttccac ggattgcccc ctgcatcaac 570121 aggaagggaa ctttgcgctc caataatata atgatgagga ttagcatgtt taaccgcttc 570181 atcaagtggc gcttgatctg taccttgact gccgacacct tcaccgcctg attcatctaa 570241 taaagcattg attgtgtttt gaaccagttc aacgtgggca atctcctcta aaaaaatgcc 570301 gcgaagcaga tcgcggtact gtttctgctt tcctctgaaa ttagagcttt ggaaaaaaac 570361 tgcatcattg tacgcatttc tccgtaatga ccgcctaata tctcctgcag gaccttagca 570421 gctgccgggt ctggcttgtc cggtttaatg atattaatca gttcctcttt gtagtaatac 570481 ataacacgcc tcatttcttc ttaagagatt ttcttatatt atttgtaaga tgagataaaa 570541 tatatacatg ataagcatgg gaaggcgtga aagaagaaaa taaaaaaata caggaaaagt 570601 gttgaccaaa taaaacaggc atggtatatt attaaacgtc gctgatgaac agcgtgaaac 570661 aaaacagaaa aacaaaaaag ttttcctaag gtgtttacaa gattttaaaa atgtgtataa 570721 taagaaaagt cgaattgaaa aagattcgaa aaaacattaa aaaacttctt gacttcaaca 570781 tcaaatgata gtatgatagt taagtcgctc aataagcgcc cgtagctcaa ttggatagag 570841 cgtttgacta cggatcaaaa ggttaggggt tcgactcctc tcgggcgcgc catataagat 570901 accacgcggg tgtagtttag tggtaaaacc tcagccttcc aagctgatgt cgtgagttcg 570961 attctcatca cccgctccat tattgaatga tctttgaaaa ctaaacaaga caaaacgtac 571021 ctgttaattc agtttttgaa aatcgcacag cgatgtgcgt agtcagtcaa actagggcct 571081 gcacgatgca ggtcacacag gtgtcaccgc gggatgcggt ggacttaacc tgtgatccat 571141 ttatcggaga gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa 571201 gtcgagcgaa cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg 571261 tgggtaacct gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt 571321 tgtttgaacc gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc 571381 cgcggcgcat tagctagttg gtgaggtaat ggctcaccaa ggcaacgatg cgtagccgac 571441 ctgagagggt gatcggccac actgggactg agacacggcc cagactccta cgggaggcag 571501 cagtagggaa tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga 571561 aggttttcgg atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg 571621 gtaccttgac ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa 571681 tacgtaggtg gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct 571741 taagtctgat gtgaaagccc ccggctcaac cggggagggt cattggaaac tgggaaactt 571801 gagtgcagaa gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag 571861 gaacaccagt ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg 571921 gggagcgaac aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt 571981 tagggggttt ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta 572041 cggtcgcaag actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt 572101 ggtttaattc gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta 572161 gagataggac gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg 572221 tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc 572281 attcagttgg gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg 572341 tcaaatcatc atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag 572401 ggcagcgaaa ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt 572461 ctgcaactcg actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg 572521 aatacgttcc cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga 572581 agtcggtgag gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga 572641 agtcgtaaca aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat 572701 tatacggaat ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt 572761 gaaggatcat tccttcgaaa cgtgttcttt gaaaactaga taacagtaga catcacattc 572821 aattagtaat acaagatatc acatagtgat tctttttaac ggttaagtta gaaagggcgc 572881 acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg atatgcttcg 572941 gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca ccactcgtaa 573001 tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg ggaactgaaa 573061 catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa 573121 cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc tgtacggagt 573181 tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag gtaacagccc 573241 tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac acgtgaaatt 573301 ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga ccgatagtga 573361 accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa 573421 accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct tttgtagaat 573481 gaaccggcga gttacgatcc cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag 573541 cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca 573601 tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca cgttgaaaag 573661 tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat agctggttct 573721 ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga gcactgattg 573781 gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca atgacttatc 573841 cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag cccagaccgc 573901 cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct tagacaacca 573961 ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac tggtcgagtg 574021 actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg 574081 aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac tggtggagcg 574141 cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc ctccaccgaa 574201 tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc taagccgagg 574261 ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc tcaccatttg 574321 agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg cgtccaagca 574381 gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat ggcgagcgaa 574441 atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg aggtgagagg 574501 tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg atcgagagaa 574561 ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta 574621 gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag caaaaacaca 574681 ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt gctggaaggt 574741 taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt 574801 aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa 574861 ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag tacctgtgaa 574921 gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc agcctgatat 574981 tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga gcgccagctt 575041 cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc cgccgccctt 575101 atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg 575161 taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag agtgtaaagg 575221 cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc gggcttagtg 575281 atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc ccggggataa 575341 caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc gatgtcggct 575401 catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca ttaaagcggt 575461 acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg 575521 aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc gctggtgtac 575581 cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa gtgctgaaag 575641 catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga agtaagatcc 575701 ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat ggagctgaca 575761 gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct gttatctagt 575821 tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca cccgttccca 575881 taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt ccccctgtga 575941 gagtaggacg ccgccaagca ttacttttat catcgcgggg tggagcagtt cggtagctcg 576001 tcgggctcat aacccgaagg tcgcaggttc aaatcctgcc cccgcaacca aatatatggt 576061 taaataagga gtgccctaag ggtgcaacca aaataatcct atacaaatat ggtccggtag 576121 ttcagttggt tagaatgcct gcctgtcacg caggaggtcg cgggttcgag tcccgtccgg 576181 accgccatta atgtaaacga aacgatcatg ttttcgtttt ttttgtgttt tcttttactg 576241 tatcttctgc ttggtgtcat agccaagctt tctttatatc gggaacatct tggatattcc 576301 agcaaaattc gataaactag gaagagcaca aataggcata agcagggttg aaaggaggtt 576361 ttggttcatg gatgaatttg atttgataca tagcattact ccgcggacca ttcaccattc 576421 ttccgttgat gtaggaatag gtgatgatgc agcgctctac actgcgaaac acggcgttca 576481 ggaaattgtt tgtgttgata ctatggtaga agacgtgcac ttcaaattac actattcctc 576541 acctgaagat atcgggtaca aggcgttagc cgttaatata agtgatattg ccgcgatggg 576601 aggcattcct aagttttatc tggtatcact tgcggtacct tcaaaatgga ctgaatctga 576661 aatcaaggcg atgtatgaag gaatgaatga actggcgaaa ctatatcata tggatctgat 576721 tggcggcgat acagtttcta ccgctgacaa attagtcgtt acagtcactg taatcggtga 576781 aattgaaaag ggacaggcct gtttgcgcag cttggcaaaa ccgaatgata ttgtgtttgt 576841 aaccggtgaa atcggttctt ctgcagcagg gctttcttta ttgctggaag agactaatcc 576901 tcaaaactca tctgtggaaa cggattactt tatccacagg cataaacggc ctgagccaag 576961 agtaagcgtc ggcagattat gctcgatttt taaacgggca gctttaaatg atgttagtga 577021 cggattggct agtgaactga acgagattgc agaagccagc tgtgtttcaa ttgaaattgt 577081 tgaaagcatg cttccaattc attctgattt gcctaagctt catcctaact ggaaagaatg 577141 ggctttgttt ggcggtgagg attttgagct gacagggacg gtttcaaatg aggagtggga 577201 agtgttgaag caggagtgcg cagcgcttca tcttcccatt acaaagattg gctatgtcag 577261 ggaaaaaaca aaatctaaag tgatcctaaa aacagatcaa acatcaatga tcttagagaa 577321 aaagggatat aatcatttta aataagacgg gtgactcgtg tgaagcaatt aaaatggaga 577381 actgtaaatc cagaagaaac aaaagcaatt gccaagctga cggcagcgtt tgctaaaccg 577441 ggagacgtcc tgacattaga gggcgattta ggtgcaggaa aaacgacttt tacgaaaggt 577501 tttgcagaag ggctgggaat tacacgtatt gtaaacagtc cgacttttac aattataaaa 577561 gaatataacg atggcgtact tcctctttat cacatggatg tgtatagaat ggaagatgaa 577621 agtgaagatt tgggacttga tgaatatttt cacggacaag gtgtctgtct cgttgaatgg 577681 gctcatttaa ttgaagaaca gctgccacag gagcgactgc aaattgtcat caaaagagct 577741 ggtgatgatg agcgggaaat tacctttact gctgtcggga atcggtatga aatgctttgt 577801 gaggagttaa gtagacatga caatattagc aattgataca tcaaattata cattgggcat 577861 tgcgctgctt cgagaagaca ctgttatagc agaatacatt acatatttga aaaagaacca 577921 ctctgtaaga gcgatgcctg ctgttcattc attgctgaat gattgtgata tggcaccgca 577981 ggacctttct aaaattgtcg ttgcaaaagg ccctggttca tacacaggag taagaatagg 578041 tgtgacgttg gccaaaacac ttgcctggtc tttagacatt ccaataagtg ctgtatcaag 578101 tcttgagacg cttgcggcaa atggccggca ttttgacggt ctgatcagcc caatctttga 578161 tgctagacgg ggacaggtgt acacaggtct gtatcaatat aaaaatgggc ttttagagca 578221 agttgttcca gatcaaaatg tgatgctggc agattggctg gagatgctaa aagaaaagga 578281 ccgccctgtt ttgtttttag gccatgatac ttctcttcac aagcagatga tcgaggatgt 578341 gcttggaaca aaaggattca ttggaactgc cgcccagcat aacccgcgcc cttcagaatt 578401 ggcttttctc gggaaggaaa aggaagcagc tgatgttcat gggcttgtcc cggattactt 578461 gcggctggca gaagctgaag cgaaatggat tgaaagtcaa aagtagggtg ataggatgaa 578521 aacaaaagca gcggtcagaa atatgcggct tgaagatata gatcacgtat acgaaatcga 578581 agcatcctcc tttacgtctc cttggacgaa ggattcgttt tatcatgagc tgctggaaaa 578641 tccgtatgct cattatctcg tgattgaaaa ggacggccat cttgctgggt attgcgggat 578701 ttggattgtg atggacgatg cccagattac aaatatagcg ataaaaccag agtatcgcgg 578761 ccagtcttta ggagaaacgc tttttcgctc agctgttgaa ctgtgcaaag aaaaagacgc 578821 aaggcggctt tcgcttgaag tgagggtttc gaatcatcct gctcaaggct tatataagaa 578881 attcgggatg cagcccggcg gaataagaaa gaactattat actgataacg gggaagatgc 578941 gttaattatg tgggtgacga taaatgagtg agcaaaaaga catgtacgta ttaggaattg 579001 aaacaagctg tgatgagact gctgcagcta ttgtgaaaaa cgggaaagag atcatttcaa 579061 acgtagtagc ctctcaaatt gaaagccata agcgcttcgg aggcgttgtt ccggaaattg 579121 cttcaagaca tcatgttgaa caaatcactt tggttataga agaggcgttt cgcaaagctg 579181 gcatgacgta tagtgatatt gatgcgattg cagtaacaga aggtccggga ctggtgggag 579241 cgcttcttat cggagtgaat gccgctaaag cattgagctt tgcatataac attccgttag 579301 taggcgttca tcatatagcc ggtcatatat acgcgaaccg tcttgtagaa gacatcgtgt 579361 tcccggcact ggcattggtc gtttcaggag gccatacaga actggtttat atgaaggaac 579421 atggatcatt tgaagtcatt ggggaaaccc ttgatgatgc ggcaggagaa gcctacgaca 579481 aagtggcgcg gacgatggga ttgccatatc cgggtggacc gcaaattgac aagctagctg 579541 aaaaagggaa tgacaatatt ccgcttcctc gcgcatggct tgaagaaggc tcttacaact 579601 tcagctttag cggattgaag tctgcggtga tcaatacgct tcataatgca tcccaaaaag 579661 ggcaagagat tgctccggaa gatttgtctg ccagtttcca aaatagtgtg atcgatgtct 579721 tggtaaccaa aacggcgcgc gcggcaaagg aatatgatgt caaacaggtc cttttagccg 579781 gaggagtagc tgcaaacaga ggcctcagag ctgcattaga aaaggaattt gcccagcatg 579841 aagggattac gcttgtcatt cctccattag ctttatgcac ggataatgct gcgatgattg 579901 ctgctgctgg tacaattgct tttgaaaaag gaattcgcgg tgcatatgat atgaatggcc 579961 agcccggcct tgaattgact tcttatcaaa gtctcacgag ataatagcgt gagacttttt 580021 atctgtttgt tattaacaga caattcacaa tttatccaca tatctgtgag taattataga 580081 gatattgatg gataaagggc tgaggtcact gttaataaag tggataaatt cagaatattt 580141 tgtggatagt gtgtataaag cgcttacttt gtttatttat taggggatgt tctgtggata 580201 aaaagcacct ctaaaaagag gtgcttgact tttttaatct tcttctgtgg atagttcttc 580261 ccattcggac aaaagagatt ccagctcctg attaagcttc tcattgtctg catggatagc 580321 ttgtactttt tcatgatcct gatagacttc agggtcacat agcaattcat cattgcggct 580381 gatgttctcc tcaatggttt gaacggtggt ttcaatttct tcaatccgac ggagtcgttg 580441 gcgctctttc tttttccatt ctttttcttc ctcgtaggaa cgtttggagt cagacttcac 580501 tgtagctggc gttttatcag tttcctcttg ctgattcatt ttctccaatt caagctgctc 580561 tgtttttttc tctgtataat aatcgtaatc tcccagatac tcctctatat ggcttgaaga 580621 aagctccaat actcttgtgg cgattctgtt aataaaatat ctgtcatgtg agacaaataa 580681 cagtgtgcct ggataatcaa tcagcgcgtt ttcgagaact tctttgctgt ctaaatccag 580741 atggttcgtc ggttcatcaa ggatgagaaa gttggctttt tgaagcatca gcttagctag 580801 agccaatctt gctttttcgc ctccgctcag tgaatgaact ggtttcagca catcatctcc 580861 ggagaataag aaatttccga gacacgttct gatttctttt tctgggagcc cggggtactc 580921 gtcccacagc tcatcaagga cacgtttaga ggaagtcaac tcagcctgtt cctggtcata 580981 atagccgaca ctgacatttg agccgtaaga aattgttccc tgatctggtt ttagggtgtc 581041 tattaatgtt ttcagcaatg tcgatttacc tattccgtta gggccgacaa gcgcagcgct 581101 ttctcctctt gtgagcatga atgacacttc tgttaaaagc ggcggctggt tttcatagct 581161 gattgtgaga tcctgaacac gaaggacttc atttccgctc tgttttgtaa tatcaaaatg 581221 aaagtttgcg gatttttcat cgccaagcgg ttttgacatg acatccattc gctcaagctg 581281 ctttctgcgg ctttgcgccc ttttggtggt agaggctctc gccagatttc gatctacgaa 581341 gtcctgcagc tttgcaatct cgtcctgctg cttttcatac attttcagat ctttttcata 581401 ctgcgcggct ttttggtcga gataagcgct gtagttgccg tgatactttt tgctttctgc 581461 tcttgatacc tcgtatacct ggtttactac tttgtccaaa aagtagcggt catgcgaaac 581521 gatgagaatg gcgcctgaat agccttgtaa ataatgctca agccaggtaa gcgtatcaat 581581 atccagatgg tttgtcggct catcaagaat gagcaaatca ggctgtgtta atagaagctt 581641 acctaaagcc agtcttgttt tctggcctcc gctgaggctt tgaacctgtg tagaatcgtc 581701 aaaatggctg aagccgagac catgcagcac agatctaaca tccgcttcat attgataacc 581761 gcctttatct ttgaattcct gctgaagacg gtcgtaggtt ttcatgatgc tttctaattc 581821 acccgggtca gctgccgcca ttttttcttc catagcccgc atttcctttt ccattgcttt 581881 taagtggtca aaaacagtca gcagctcttc ttttatggta agcttagaat ccaagccagt 581941 atgctgggcg agatatccca ttgtaatatc tttcggttta ataatttcgc ccttttcata 582001 cgaaagctgg cctgcgataa ttttaaggag cgtggatttt ccggcgccat ttcttcctac 582061 aatggcgatg cgatcacgat ttctgacttc cagctttata ttgtttaaaa tagtatcagc 582121 accaaatgat ttggacagct gattaacttg taagatcatc atattatttc acctctgcta 582181 taataagtta agtgtagctt atgaaccaga agtcagcaaa caatacattg gccatataag 582241 acatagagaa gaaaatagtg tatgatctgt ttaaggagcg ttttaatatg aatggatttt 582301 ctcattttaa tgaacagggc agagcccaga tggtggatat tagcgaaaaa tcttcgactg 582361 tccgtactgc ggcggctgtt tcaagcgtac acatgaagaa tgaagtgtac gagaaaatac 582421 aaagtcacga tatcggcaaa ggagatgtac tggctgtcgc acaggtggca ggcattatgg 582481 ccgcaaagca aacgtcgaat atcattccga tgtgccatcc gctttcattg agcggggtag 582541 atatatcgtt tgactggaaa ataaaagaag cagaagttat acttcatata aaagcacagg 582601 tcaaaacgaa agggagtaca ggtgtggaaa tggaagcgct cacttctgca tcggtgtgcg 582661 ctcttaccgt ttacgatatg tgcaaggccc ttgataaggg aatggtcatc ggccctactt 582721 tcttgctgga gaagacaggc gggaaaaacg gtgactttaa aagagaacta tccgagtata 582781 atttggagga ccaaaaatga ataaggatca atcaaaaatt ccgcaggcga cggcgaaacg 582841 gctgccgctt tactatcgct ttttaaagaa tctgcatgcg tcaggaaaac agcgtgtatc 582901 atccgctgaa ctcagtgatg ccgtaaaggt tgattctgcc acgattcgga gggatttttc 582961 ctattttgga gctcttggca aaaaaggata cggatataat gtggattatt tgctgtcttt 583021 tttccggaaa acgcttgatc aggatgagat gacagacgtc atcttgattg gtgtcgggaa 583081 cttgggaacg gcatttcttc actataattt cacaaaaaac aataacacaa aaatttctat 583141 ggcttttgat ataaatgaga gtaaaatagg aactgaggta ggcggcgtgc ccgtctataa 583201 ccttgatgac cttgaacaac acgtaaaaga tgaatcagtt gccattctta cagtgccagc 583261 agttgccgct caatccatta cagacagatt ggtcgcatta ggaatcaagg gaatccttaa 583321 ttttacgccg gcccgtttga atgtgccgga acacattcga attcatcata tagatttagc 583381 agttgagctt cagtcactgg tttatttttt gaagcattat tcagttttag aggaaatcga 583441 atagagggaa aggaggagcc caaatatgcc gatcggtcct ggaagccttg ctgttatcgc 583501 aatcgttgct ctgattatct tcggtcccaa aaagctgcct gaattgggga aagcagcggg 583561 agacacactt cgtgaattta aaaacgctac taaaggatta acgagtgatg aagaggaaaa 583621 aaagaaagaa gatcagtaag ttaggatgac acgaatgaaa gtgaatcaaa tgtcgctgct 583681 ggagcatatt gctgagcttc gaaaacggtt gctgattgta gcgctggcgt ttgtcgtttt 583741 ctttattgct ggattttttt tagcaaagcc gattattgtg tatctgcaag aaacagatga 583801 agcgaagcag cttacgctta acgcgtttaa cctgacagac ccgctttatg tgtttatgca 583861 atttgcgttt atcatcggca tagtcttgac ctcgccggtt attctttatc agctttgggc 583921 ttttgtgagc ccgggcctct atgagaaaga gcgcaaagta acgctcagct acattccggt 583981 ctctattttg ctgtttttag cgggcttatc tttttcatat tatattttat ttccttttgt 584041 tgttgatttt atgaagcgga tttctcagga cttgaatgtc aatcaggtga tcggaattaa 584101 tgaatatttt cattttcttc tgcagctgac gattccgttt ggactgctgt tccaaatgcc 584161 ggtcatcctc atgtttttga caaggctcgg aattgtgaca ccgatgttct tggcgaaaat 584221 cagaaagtat gcgtatttta cgctgctggt gatcgcagcc ctgattacac cgcctgagct 584281 tctgtcccat atgatggtca cagtcccgct tttgatttta tatgaaatca gtatccttat 584341 atcgaaggcc gcttatcgga aagcacagaa aagcagtgct gccgatcggg acgtgtcttc 584401 tgggcaataa taaaaaatcc atttctcatg cgagaaatgg attttcttta tttttggttc 584461 tttttgattt taaatgaaaa ggcgaacatc ttaaaagaaa tgctgatgtt gtaagcggcg 584521 aacaccatca gcaggatgga gtaaaatgac cacatgctgc ctggcgagct tgcggcaaga 584581 taagtaaaga tgcaccctac ggcaaagtag atcattcccc aaactaccgg gtttctcata 584641 aaaataatcc tccaataatc aattgcattt gtgtgctctg ctgttcaagg taattacgaa 584701 caggctcaag ctgcatgatg acgacgaatg tattcatcat taaatgggcg aaaatcggca 584761 cccatatccg ttttgttctc gcatataaaa aggcaaaggt aaagcccatt gctgtatata 584821 gaaggagatg cttcaaatca gcgtgaacaa taccgaagat aaccgagctg atcagtcctg 584881 cgaaaaagaa attcgttttt tcgtacagcg cgccgaaaat gatttttctg aagatgattt 584941 cttctaatat aggcccgacg atggaagaaa cgataatcat gagcgggact gcctgaatga 585001 catccagaat cgcttgtgta ttttctgatt ctcttccgat gccaaaaaca taatattcaa 585061 tagagcctgc tattccttga gagaaaaggg caatgaaaaa accggctatc gcccaaagga 585121 tagaaagtcc gattgagtcc ttctgtccgt ttcgcagcgt ttctttcgga acggttctca 585181 gaatgagcag aacaacaacg agacaggcga taaagctgat aacggaccat aatccttgtg 585241 catgcagcat attttcatct gtaggctgtc ctccggcata accgaattta aataacaagg 585301 gaatcgcgat taatgcggaa aactgcatga tgatatatgt caaaataata aaccaatact 585361 gttttctcaa atggtatgta ctcctttgtt aagtgggttt cgttcatcta cagctattgt 585421 aacataatcg gtacgggggt gaaaaagcta acggaaaagg gagcggaaaa gaatgatgta 585481 agcgtgaaaa attttttatc ttatcacttg aaattggaag ggagattctt tattataaga 585541 attgtgttag cactctttag tgctgagtgc taaaattaca tattcatact attgaggagg 585601 ttatttcatt gttaaagcca ttaggtgatc gcgttgtcat tgaactcgta gaatctgaag 585661 aaaaaactgc cagcggaatt gtgttgccgg attctgcaaa agaaaaaccg caagaaggca 585721 aaatcgtggc agctggttca ggtcgcgtgt tagaaagcgg agagcgcgtt gctttagaag 585781 taaaagaggg cgaccgcatt atcttctcaa aatacgcagg tactgaagtg aaatacgaag 585841 gtactgaata cttaatctta cgtgaaagcg acattttagc tgttatcggc taattcttaa 585901 ataaacaata cttaaaacat ttgaggaggt cttgtaaaca tggcaaaaga aattaagttt 585961 agtgaagaag ctcgccgcgc aatgcttcgc ggtgtcgatg cacttgctga tgctgttaaa 586021 gtaactttag gaccaaaagg acgcaacgtg gttctagaga aaaaattcgg ttctccgtta 586081 atcacaaatg acggtgtaac aatcgctaaa gaaatcgagc tagaagacgc gtttgaaaac 586141 atgggtgcta agcttgttgc tgaagtagcc agcaaaacaa acgacgttgc cggtgacggt 586201 acaacaactg caacagttct tgcgcaagca atgatccgtg aaggccttaa aaacgtaaca 586261 gcaggcgcta accctgtagg cgtgcgtaaa gggatggaac aagctgtagc ggttgcgatc 586321 gaaaacttaa aagaaatttc taagccaatc gaaggcaaag agtctatcgc tcaggttgct 586381 gcgatctctg ctgctgatga ggaagtcgga agccttatcg ctgaagcaat ggagcgcgta 586441 ggaaacgacg gcgttatcac aatcgaagag tctaaaggct tcacaactga gcttgaagtt 586501 gttgaaggta tgcaattcga ccgcggatat gcgtctcctt acatggtaac tgactctgat 586561 aagatggaag cggttcttga caatccttac atcttaatca cagacaaaaa aatcacaaac 586621 attcaagaaa tccttcctgt gcttgagcag gttgttcagc aaggcaaacc attgcttctg 586681 atcgctgagg atgttgaagg cgaagcactt gctacacttg ttgtgaacaa acttcgcggc 586741 acattcaacg cagtggctgt taaagctcct ggtttcggtg atcgccgtaa agcaatgctt 586801 gaagacatcg ctgtccttac tggcggagaa gtcatcacag aagatcttgg ccttgacctg 586861 aaatctactc aaatcgctca attgggacgc gcttctaaag ttgtcgttac taaagaaaac 586921 acaacaatcg ttgaaggcgc tggcgaaaca gacaaaattt ctgcccgtgt gactcaaatc 586981 cgcgctcaag tggaagaaac aacttctgaa ttcgacagag aaaaattaca agagcgtctt 587041 gctaaacttg ctggcggcgt agctgtcatc aaagtcggcg ctgcgactga aactgagctg 587101 aaagagcgta aacttcgcat cgaagacgcc ttgaactcaa ctcgcgcagc tgttgaagaa 587161 ggcatcgtat ccggtggtgg tacagcgctt gtaaacgtat ataacaaagt cgctgcagtt 587221 gaagctgaag gcgatgctca aacaggtatc aacatcgtgc ttcgcgcgct tgaagagcca 587281 atccgtcaaa tcgcacacaa cgctggcctt gaaggatctg tcatcgttga gcgcctcaaa 587341 aacgaagaaa tcggcgtagg cttcaacgct gcaactggcg aatgggtaaa catgatcgaa 587401 aaaggtatcg ttgacccaac aaaagttaca cgctcagctc ttcaaaacgc tgcgtctgta 587461 gctgcaatgt tcttaacaac agaagctgtt gtcgctgaca agccagaaga aaacggtggc 587521 ggcgcaggaa tgcctgatat gggcggcatg ggcggtatgg gtggaatgat gtaataaagg 587581 gatattaacc cttatacatc aatgttttaa ccgtcttaaa aaactagaca aagcgtgaat 587641 aaaaaaagag aaggtctttc atcagtttac taaactgttg ggagaccttt tctccatatt 587701 agcggtcata tgagcataaa tgtccatcgt cgtatttatg tccgaatgac caaattgttg 587761 ctggatttct ttaatgccta ctcctgcctc aattagtaag gaggtatggg tatgcctaaa 587821 agagtggggg gtgacattct ttttatccca gcttttttga gcagccgttt aagtctagtc 587881 tcaataacct ttcttaattg cggatgacca tcctcccgct caaaaataaa tgatgagtct 587941 tgataaatca atctattttt aagcttaatt tcattttgat aaattttatt tttttttagt 588001 agattgacat cgtttcatca attcgaacga tatcaacaga tcctgttgtt ttaggtgtta 588061 gcaattggta tttttcaatt tgattgttag gggtgtatag ggtctttgtg acctggctta 588121 tcattgaaat ctgtccattt taaagcaaga agttcaccaa ttcttaggtc ggtctaggca 588181 agtacggtaa agaccaaatg gtccatttct agcccgtcag attgagcgag ctttagaaaa 588241 tgtgtcagca cctctttttc caatgctttg ttgcttcttg ggtaattgaa aatccccagt 588301 tgggttcatt ttaataatcc cttgagtttt agcttttcgg aaaatcatac ggccgcaggc 588361 atgaatacct cccaaacaat tgtgactgta ttgctcgttc agttctaacg tgcggtcttc 588421 atacattttt ttgtgttttg ctaatcgggt attgacccaa tactgcgata aaatgcatca 588481 ttttcttttc actggcccgt acactgctta tttttacccc actccggttg taaatcttaa 588541 gccaaccttt tgcaaatgtt ttgaagggca tatctgactc cttaataaaa gtcccgttgt 588601 cgttttggag ttctacgtga cgggctgcta ctggggcttc tttctttgtt ttaaatcttc 588661 ctttggatat ttctagacgt tttttggtta aagggtcaat gcctagtaga tatgataact 588721 ccacgtctta ccgcattgct tgagttttgc catttatttg tccctaacta attttttttc 588781 atcaaattgg tctttaagtg agtttaataa tttttgtttc tctcgactgg tcaataattg 588841 cccttcatat ttcaaaagat tggataaatt tgagatggaa tcaatcctga tggatggtac 588901 cgtagacttt aataagaaac gaaaggccaa ctgcgacttc agttggcctt tcctatttat 588961 aataaagaaa ttgagtgaga ttgctgacag aactacgtac tactcgtttt ctttagttgc 589021 ccttgctaat cgttcaacct ctccccgaat cccaatcgca ggctcccacg aatcaatcaa 589081 acgaatcgcc ttctgattag attccaccgc tttcgttttc tctcctttac gatacaacag 589141 ctgcgccatt ccgtagtgat agtagatcag ttcaacttga ttggcgttat gtttgtcata 589201 gagcatttgc tcaaaggctt cttccgcttt ttcaaactga tcacatttca cgtaagcgac 589261 acccagattg aaataggctt ctatcgtttt ttcgccgccg tatgtggagc tgatttcatt 589321 tgccgcttcg tataattgaa tggcttctac atgataacct ctcgcaaagc ttaagtcacc 589381 gcgaaccaat agaactctgt gttgaatggt aggggaaatc ggttgatttt cgatttcgtt 589441 taaaattgtc tctgcttttt cctgttgccc gtcttttaaa aacagccttg ctttgagtgc 589501 atgtccccaa acctttagat cataggcatc gtgagcgtct gattgttcaa gaatcttcag 589561 cccggcttct atttgctgaa gcgctccgtc taaatcattg acttccatca atgcccagcc 589621 tgaggtgtcg attcggaagt acgcttctcg tgtgtgttgg cctaagtgat gggcggcgtc 589681 ggccgctttg cgtccgtatt cgattcgcag gggcaggttg attctgctta gaaaatggct 589741 aatgcgggtg atgagttcga ttaggatttc tttttgttca gtttcacttg cccattggat 589801 gacctttaag atgtttggcc attcttgttt catttgatct aagttccgtc ccagcaggta 589861 gctccaatag atagagttgg gctgttcccg ctttaaatgg gtttcggcat aatcaatata 589921 atagtgcgcc cagcgattgc gggcttcttt ttcatattcg tgctgttcgg acaagtgctg 589981 ttctccgtaa gcgacaacgg tttggtgcgc taagtattgt gtcctgcctt ggcttcgttc 590041 cggctgaatc agcgcatatg accgcatttg ttccatagcg taatgaaaac ggcgggcgtc 590101 taatccggct gctgccgcca ggcttttttc atcaggcggc ttgctgaaaa agcaaagcgt 590161 ctgccagagc tttcgcgtat cttcattgca tctatcccag gtgcggccaa agaggaattc 590221 aaacaattcc agcagtgagt agcctgcttt tccaagctca tgaatcagct gctgagcggg 590281 gatgtcatcg tctgacatat aggcaatgct gagtgccatg gctttcgggt ttccggcagt 590341 cgctgaaatg aattcgtttt tcaggtcaga tgatagatgt aacagctgct ccagcttttc 590401 ccgtttacgt gggaggttgc atgtttgtaa gcagtgatgc acttcttgtt gaaaaaattc 590461 gtgggcatct gtttggtcaa gaccgcttag ctgaatggct gtcatttctc cgaagctttc 590521 ccgataagtt tgctttacgt tttcccgcgc tgtaaggaga acttttacgc cttgcggaag 590581 gctggtgata aattcatgaa tgtcacgttc tgcagtatca atgctgtcaa cgatcagcag 590641 gatcggtttt tctctagtgt aattggctaa cgcattgcgg acgacaaacc gttttacatt 590701 gattgattta tcgatttgtt ctttgcgtcc gagctgatag gcgatcgtat ttaaaaaatc 590761 gctaaagctt aatcctttcc aatcagcgct gacccagatg atgctgttga atgccggcca 590821 aactgaagta tcgtcgacac aggaataggc ggcttcaaga gcaattgtgg tttttcccat 590881 gccggcccag ccggtgatta aacagactgg tgatggagaa agcatccatt gccgtatcgc 590941 ttccatatca aagctgcgtc cgataaagcg tccggaccag cgtgagggta aattatgcgt 591001 gatgggctgt tctgtaagcg cattcgtttc ttggccgggt ctgtcatgaa acagccgttt 591061 tactacattt tcaatttcgc cttcactcgg agccccgaat aatccgtctt ttcgcagtat 591121 tttcgctttt ttcaaacagg atgctgccca tacaggcaat gcgggtttga tgactgggat 591181 agtggtggct tccagcaagt cggtcaacca ctcgatatcc aagtcggtct tttcgagaat 591241 gatccagatc attccgaaca gttttccgtc gtcgattctt ccgggaatgt agtttgcccc 591301 catctgtccg atccagcttt tgatcgtgtt tggggagact cccagctgga gtgcgatttt 591361 atctatgtaa gactgtcctg ttttttcatt ctttttcctt ctgactttat aatcaggatg 591421 aagttttagc gttttgacgc caggtgccag catttgtgca aattgttttc ggttttcaag 591481 ttcagccata agcctgcacc tcctattagt actattttat caatccagcg ttttttgtat 591541 atgaaaaaat aaaagtacag tgccgctgtc cttttataca gcaggaaagg ctgttgaacg 591601 tgttaaaaag cagataaaat gggggcagta acagagaaaa caaaaatgta tgcacttaca 591661 ttttattttc taaagaaagg aacttgccaa atgactcaca cagtacctca aaacatgaaa 591721 gcggctgtta tgcacaacac aagagagatc aaaattgaaa cattgcctgt gcctgatatc 591781 aatcatgatg aagtgttgat taaggtgatg gctgtcggaa tttgcggatc tgatctgcat 591841 tactatacaa atggccgaat aggcaactat gttgtggaaa aaccatttat ccttgggcat 591901 gaatgtgcgg gtgaaattgc cgctgtcgga tcatctgtcg atcaattcaa ggtgggagac 591961 cgcgtcgctg tagagccggg tgttacgtgc ggacgctgtg aggcgtgcaa agaaggacgc 592021 tataatcttt gcccggatgt acagtttttg gctacaccgc cggtagacgg tgcgtttgtc 592081 caatatatta aaatgcgtca ggactttgtt tttttaatcc cagactcact ttcttatgaa 592141 gaagctgctt tgatcgagcc gttttctgtc ggtatccatg cggcggccag aacgaagcta 592201 cagcccggat caacgattgc gattatgggg atgggccctg ttgggttaat ggctgttgcc 592261 gcagctaaag catttggggc aggcacaatc attgtcaccg acttagagcc gctgcggtta 592321 gaagctgcga aaaaaatggg agcgactcac attattaata tacgtgaaca ggatgcactt 592381 gaagagatta aaacgatcac gaatgataga ggcgttgatg ttgcttggga aacagcaggg 592441 aatccagcgg cattgcaatc cgcactggct tctgtgcgcc ggggcggaaa attggcgatt 592501 gtcggtttgc cttcacagaa cgagattccg ctcaacgtgc cgtttattgc ggataatgag 592561 attgatattt acgggatctt ccgttatgcc aatacgtatc caaagggaat cgaatttctt 592621 gcttcaggca ttgtggacac gaagcatcta gtaacggacc aatattcgct ggagcagacg 592681 caagatgcga tggagcgggc gcttcaattt aagaatgaat gtttaaaagt gatggtgtat 592741 ccaaatcgct gagtgaacag ggaggatctt cgtattctcc ctcttgttta ctggaaatga 592801 aaacggattc ttggggtggg aaatgatgat tggaacagaa aaagtaacgg cattgaaggc 592861 gaagcatcag tcaaaatcca gcaccggcct gtcctggttt gaacgaatcg gttatggatt 592921 cggcgatatg tcgtataata ttatctttca gtttgtaaac gcatacttat tattttatta 592981 tacagacgtc ggcggcattc agcctgcggt aatcgcaact ttgtttcttg ttgtgcgtgt 593041 gctggatgct atttttgacc cgatcatggg attgatttta gataaaacga atacaaggtg 593101 gggaaaagca aggccatatt tgctgtgggt ggcatttcct tttgcgctat tcacattctt 593161 atgtttcacg acgcctcatt tcggtgagac cggaaatatg gtatatgcgt atgtcactta 593221 tattctgctt gggatgtcct ttagtatgca aacgatcccg gtgaacagct taacggggcg 593281 gatgacgaat tcggtggagg aacgaacggt tctgaccaca acccggatga ttttggtgta 593341 tatcggcatt cttttatcca tttcctgtgc gacaccgctt gcaactgcta tcggaggaga 593401 ggatcaggcg tttggatttc agatgacggc gctcatctat gcggctgtca gcatcgtttt 593461 gaatctattt agtttcttta ctgtacggga gcggattcag cctaaaaaga gaaaaaaaca 593521 agggatcaaa aagacgttat ccgttttatt caaaaacaaa cccttgctca tgttaatttc 593581 atcatttttg gcttttgcga tcgggtttaa tattaagctc agcacgatgg tgtattattt 593641 tacgtataac gtaaaccata aagagttcgt gtttatgggc accgttttat ttttcggggc 593701 agcgctgatc agcaatttgt ttattccttt cttttctgag aagtggggca gaaaacaagt 593761 catgattatc acggcagctc tatcgcttat ttcttatgcc ggcctgcatt ttacgccgta 593821 ttcttcaatt ccactcattt tcatttggct tttcgcttcg ggatttttca caacgccttt 593881 aaatacgctt gcttggggaa tggttgcgga ttgcgtcgat tatgcggaat ggaaaaccgg 593941 aattcgcgcg gatggtgttg tgatttcgag catgagcttt attaataagc tgggtgttgc 594001 gttagccggg tcattttcgg ccatttattt aggaatcgcc gggtatgtgg cgaatacaga 594061 ccagacagtt gcgtcgttga atgcgattaa aaatatgaat gctttgattc cgggattttt 594121 cattttgctt tctattattc ttatcgcctt ctatccttta acggaaaaaa gatataaaca 594181 catcatctct gagctggagc aaaggtctgc gagataaata gatgtaaaat ttttaatatt 594241 caatgttgta tttatggcaa aaagtaatat actgagactg taatctagac tttataaatg 594301 agtgtgataa tatgcgtagt cattctgtag tttgtattgg ggaattgttg attgatttct 594361 tttgtaccga tgttgacgtt gatttaatgg aagggcgcca attcctgaaa agtgccggcg 594421 gggcaccggc gaatgtgtcg gcagcgattg ccaagctggg cggagacgcc gctttcagcg 594481 gaaaagtagg aaaggatccg tttgggtatt ttctgaagcg aacattggac gctgtacatg 594541 tcgatacctc tatgctggtg atggatgaga aagcgcctac aacgcttgct tttgtttcat 594601 taaaacaaaa tggagagcgt gactttgttt ttaatagagg cgcggacgct ttgtttacgc 594661 tggaggacat tgaccaggaa aaactaaacg aagcgaaaat ccttcatttc ggctctgcga 594721 cggcactgtt atcggatccg ttttgctcag cctatttacg gttgatgtcg attgcgaaag 594781 acaatggaca gtttatttcg tttgacccta actaccgtga agatttatgg aggggaagag 594841 tctcagagtt tgtaagtgtt gcgaaaaaag cgatcgctgt aagtgatttt gtgaaagtca 594901 gtgacgagga acttgagatt atcagcggtg tgaaggatca tgaaaaggga gttgcgatcc 594961 ttcatgagat cggagccaac attgtcgctg tgacacttgg gaaaagcgga acgcttcttt 595021 ccaatggaaa agaccgtgaa atcattccaa gcattccggt gacatcaatt gactcaacag 595081 gggcgggaga tgcttttgtc ggtgcggctt tatatcaatt ggcaaacacg gatcagattc 595141 aatctgtaga tgctgatttt gtgaaactgc gtgagattgt ggcgtttgcc aataaggtcg 595201 gagctcttgt gtgcactaaa attggagcga ttgatgcact gccgagtttg gatgagattg 595261 gagtttcttt gtaaatcatt gaagatgttt cttgaaagtc tttggacttt tgggggcatc 595321 tttttttatt gcttacattt ttgttcaggt aaaaagttgt atattttttg tttgaaatgt 595381 cattttttat taaaaaagtg aaacttttaa cgataataaa tagtatatgt aacaagggtt 595441 accgaattag ctttaggagg aacgatataa tgagtataat tggaagattt aaagatatta 595501 tgtctgcgaa tatcaatgct ttattggaca aggctgaaaa tccggagaaa atggtagatc 595561 aatatttaag aaatatgaat agcgatttgg ctaaggttaa ggcagaaaca gcagctgtta 595621 tggctgagga gcagagagca aaaagagaat atcacgaatg ccaggcggat atggaaaaga 595681 tggaaagcta tgcaatgaag gcgctgcaag ccgggaatga gagcgatgcg agaaaatttc 595741 ttgaaagaaa aacatctttg gagtcaaagc tttctgagct gcaggcggcg aatcaaattg 595801 ctgcaaccaa tgccgcacag atgagaaaga tgcatgacaa attggtatct gacattggag 595861 agctggaagc acgcaaaaat atgatcaagg cgaagtgggc agtagcgaaa acgcaagaaa 595921 gaatgaacaa actgggcgct tctgtttcaa gtacaagcca atcaatgtct gcattcggcc 595981 gaatggagga caaagtaaat aaggcacttg atcaggccaa tgcaatggct gaactgaaca 596041 gcgctccgca ggatgatatg gctgatctgt ctgcaaagta tgacactggc ggttcaagcc 596101 aggttgatga tgaacttgcg gcgttaaaag cgaaaatgat gctcgataag taatacatag 596161 gaggccgcag ctttcggctg cggcgtcatt ttatcataaa atgtgagagg gaacggtaat 596221 gataatatct tataagtgtc cgaactgcgg cagtgatatg gcatttgaca gtgaaaccgg 596281 ctcgttatcc tgcagcagct gcggaagaca ggacaatatt gaaagccttc cgaaagaaaa 596341 cattgcggca cggttttctg atgatgaagc aaaagaatat caatgtaaaa actgcggtgc 596401 cgttttgatc acggaagctg aaacgacagc aacgacgtgc agcttctgcg gaggtgctgc 596461 aatacttgcc gatcgtttat caggacattt ggcgccggcg aaggtcattc catttacaat 596521 cagcaagcaa gaagcggagc aggcatttcg aaagtggtgc aaaaaaggcc ttctgacacc 596581 aagaggtttc atgtctgctg atcgtatcaa aagcatcacc ggcatgtata ttccattttg 596641 gatgtttgat ttaaatagtg aagtacaggt gagagcaaac tgtaccagag tccatcaata 596701 tgaagaaggg gattatattt gcacggaaac agagcacttt gaagcgtttc gtgatatcaa 596761 tctcgattat ttgaaaatcc ctgtcgatgc ctctgaaaaa atgaaagacg aattaatgga 596821 caaattggag ccttattcat acgaagagct gaaggacttt caaacggcat atttggccgg 596881 ttatattgcg gaaaagtaca attataccga tgaggagctt tttccgaggg caaaagagaa 596941 aatcagcagt tatatagatt catacatcca ttctactttt tccggatata cgtcagtcaa 597001 tgtgagggac aaacatattc acacgaaaaa cgtgaacagc ttttacgttt tgcttcctgt 597061 ttggatggtc agttacgatt atgaaagagc ggagcatatc tttgcgatga acgggcaaac 597121 aggaaaggtc gttggaaagc cgccgatcag tcgaggaaaa gtggctgcat ggtttagcgg 597181 aatagcaggc gggacatttc ttgcgttgaa gctcgtctca ttgatgatgg gaggcggatt 597241 ttgatgcgtg gattttttgg gaaagcgatc tttgttgtgc tggctgtttt catcatgatg 597301 cctttactgg gtatcgaagc ggtaagagcc tctgaattgc agcagcatgt gtacgatcgc 597361 gctcatctat tgtcaaaagc ggagatcgga aaacttgaat ctctctcggc aaagctgggt 597421 gcaaagaggg acactgattt catcattatt acgaccaaaa gcacaaacgg tgaagatatt 597481 gcagactata ccggcgattt ttatgatcgt tacggaaaag gcagtacagc cattctgacg 597541 attgatatga caaacagaga agtgtttatc gcaggcttta aaaaagccga acagtatttg 597601 gacaacagca ggctcaatag catcagaaat acgatttcat ctgatttatc caatgaaaat 597661 tattttgaag cttttgagac atatattcag ctttcctata aagatatggg cataaaaccg 597721 ggagtaaacc ctgacaacat attctttaca tggtggtttc agctgattgc tgccatcgca 597781 gtcgggggaa ttgcggtttc aatcatgctt tatcatgcag gcggcaaagt aacggttaat 597841 ggaagtacat atatggatca gcgtacgtct gatgtgattg atcaatacga cacttatatt 597901 agaacgactg taacaagaga aagaaaacca tcagataaag acagcggcag cgatggcggt 597961 gttacgaaag gcggcacgtc atacagtggg agccggggca gtttttaaat gtaagaaata 598021 gagaaaggga gaggcgtaat gtcgtttttc agaaatcaat tagcgaatgt agtagagtgg 598081 gaagaattta gagatgatat gattttttat aaatggaaca atcgtgaaat caaaaaaggg 598141 agccgtttaa tcattcgtcc cggacaggat gctgtctttt tgaacaatgg gcgggttgaa 598201 ggagtctttc aagatgatgg cgattatgat attgaatcag aaattattcc attcctttca 598261 acgttaaagg gctttaagtt tggctttaac agcggcatgc gagctgaggt gctgtttgtc 598321 aatacgaagg aatttaccgt aagatgggga acaaaacagg cgataaatat tccggcagcg 598381 ggaatgccag gcgggatgcc cattcgcgca aacggcacat ttaatttcaa ggtgcaggac 598441 tatatcagcc tgattgataa aatcgctggc gtgaaagatc aatattttgt agaggatatt 598501 aaaacccgta tcatttctat tctggatcag cttctcatga agtggatcac aagagaaggg 598561 aaagatatgt ttaatcttca agcaaacgct tttgatattg ccaagggaat tcaagaggac 598621 ttagatatgc aattaataag cgacgggatg acggtcactg gttttcaaat catgagcttt 598681 aattatcctc aagaggttca agatatgatt acaaagaacg cttcctacgg tatggttggg 598741 gatgtgaaca gataccagca aatatcaatg acggatggaa tggcatccgg aaagatgagc 598801 ggaagcggag cggcttcgga tatggctgga atgatgatgg gaatgaatat ggccaatcag 598861 atgatgaacc aaatgaatca gaatcagcag gcacagtcat caggcccaca gtcaactggc 598921 agcggaagca aaccgaattt ctgtccaaac tgcggaacaa aaacgggcga agccaatttt 598981 tgtccgaatt gcggccagaa gcttgtataa gaatcataca gtgaaaagtc cggagtgatc 599041 agcactcggg acttttttat ttaggagaat aagcattacc tattgcttgc tcctgaacag 599101 gccattttcg agcccccgct tggataattc ccagcagcaa ttgacgacgt tcctttattg 599161 aattgacggc aatttgaaat gtttgctttg ataaagccgg tatgcctgat tgttgaagct 599221 ttgagatgtc tggttctggc ggcgcttgtt ctgcaggatg gatataggca gtatgaacgg 599281 tatccagata gtttttgata cttgagcgcg cttctttgat atgaagctga ttcggctgat 599341 attgttcagg aattccgtat ttgaaaatgg ttagagcctc atccaataca gcaacagcta 599401 taatggatga ttcctgatgc tgcgtgctgt ggtaaaaatg aaggatgggg aaggcgttat 599461 gctgagcggt cagctttccc agttctgatg aggcagcgac aagaagaaaa tcaatgtcgt 599521 gaaaatcttt gccattccat gcattatgga cgatttcagt tccgtcatgc cctagactta 599581 atacactttg ggcaaaggag cgtttttgat taaccgcact caagacggaa atcaaatacg 599641 tgacagaaaa tgtgatggta agcagtcctt gagctgtttc aataatcgtg acaagcttcc 599701 ataggcctcc gttcggagcg aggtcgccat ttcctaatgt aaacatgaca tagccggaaa 599761 aataaattcg gtctgaccag gaagccggtt cttttgattg agtttccata agtgagtgag 599821 ggtcactcga gtaaatcaaa acccacccgc tccaaaatag actgatccat atcactaacg 599881 tcaggcataa cagcagagga ccagccatac ttagaacctt tgcgtggtca ccgctgattt 599941 tgcggcagcc cttccacagc caggcagaca ggcatcttgt gatcgggccg gcaccgctct 600001 ctaaccataa cgtggtccat aaaaaatcaa tcatccccgc tgtcaataat aaaaggcctg 600061 caatgatata accctcattc attttggttg cctcccttaa gtcagccttc ttttattttc 600121 ttctctattt ccttttatcc tgagtctgaa acaattgaac gaatgtttga ttttacagag 600181 aaaaataggt gggagttacc caacacttac tcatttttca atatgaacag aaaatcacaa 600241 gatttttgac ttgattcaca cattttcatg aagaaaaacg ttcattttcc ccttgaattg 600301 gtgattttcc ttttatagag taaaaaattt tcagaaattt atattgactg aaagcgtttt 600361 tataattatg ataatatcag atataacaaa aatgtcacta taacatcact acaattgaac 600421 tattaagtga ctaataaata ccaaatgaac gaggttatgc acaaagaaat gaccattgtt 600481 cttttaacga gaaatgaaat cgcttccata gggattgaca tgctaagaag aagggaaggt 600541 tatgaggtta ttggataaaa acatgaacaa ctattttctg aagcctgctt acgaaatgtg 600601 aggaaggcag cagccctgga ataagttttt gacatacgca ttttgaaaaa gactggggga 600661 aacagtatga ataaacaagg aaatcaaatg tcatttttac gtacaattat tttagtctcc 600721 actttcggcg ggcttctttt tggctatgat accggtgtgc tcaatggagc tttgccgtat 600781 atgggagagc cggatcagct taatctcaat gccttcacag aaggccttgt caccagttca 600841 cttctttttg gagcggcact gggtgctgtg tttggcggca ggatgtctga ttttaacggc 600901 cgccgcaaaa atattttgtt cctcgctgtt atatttttta tttcaacgat tgggtgtacg 600961 tttgcaccaa atgttacggt catgattatt tcccgttttg tgctcggtat tgcggttggg 601021 ggtgcatccg taacggtgcc tgcctattta gcagagatgt ctcctgtgga aagcagggga 601081 cggatggtga cgcagaacga attgatgatt gtatcaggac agcttttggc ctttgttttt 601141 aatgcgatcc ttggaacaac aatgggagac aactcccatg tgtggaggtt tatgctggtc 601201 attgcgtcac ttccagcctt gttcctgttt ttcggcatga tcagaatgcc cgagagtccc 601261 cgttggcttg tttctaaagg aagaaaagaa gatgctttgc gtgtattgaa aaaaatcagg 601321 gacgaaaaac gggcagcagc tgagctgcaa gaaattgaat tcgctttcaa aaaagaagac 601381 cagcttgaaa aagcgacatt taaagatctt tcagtcccat gggtgcgccg tattgtgttt 601441 attggattag ggattgcgat tgtacagcaa attacaggtg tgaattcgat tatgtattat 601501 gggactgaaa ttctaagaaa ttccggtttc caaacggaag ccgctttaat cggaaatatt 601561 gcgaatggcg tgatttcggt attggcaaca ttcgtcggaa tctggctgct gggaagagtg 601621 gggcgccggc cgatgctgat gacaggcttg atcggtacga caacagcatt attgctaatc 601681 gggatattct cacttgtact tgaaggatca ccggcacttc cgtatgtagt cctgtcatta 601741 acggtcacat ttcttgcttt tcagcagggc gccatttcac cagtgacttg gctgatgcta 601801 tctgaaattt tcccgcttcg ccttcgcgga ctgggaatgg gtgttacggt attctgtctg 601861 tggatggtga attttgcagt cagtttcacg tttccgatat tgctggcagc tatcgggctg 601921 tccacaacgt tctttatctt cgttggatta ggaatttgct ctgtcttgtt tgtgaagagg 601981 tttttgccgg aaacgaaagg gctttcgctt gagcagctgg aggaaaactt ccgcgcttat 602041 gatcacagcg gggcaaagaa ggattctggg gctgaagtga ttggataatt taaaaaagaa 602101 tccgcacccg agtgcggatt ctttttggtt tcaaattagt taggtctaac aaggattttg 602161 acttggcttt tctctttaat aagagccccg aagccttcct cgatcaaatc atctagtacg 602221 atttttttcg ttacgagttt gtcggctgag aaatagcctt ctttcattaa tgacaataca 602281 gccgggaaga tgtcgcggta tccgataatt ccttttactg tacgttcttt gattacgata 602341 tcgttcggat ggatttcagc acctttttcc caaatgctga cgatgacggt ttcaccggca 602401 attgtagtgg actggatggc ttgtcgtaac accactggga caccagtgac ttcgaatgct 602461 acgtcaacac cgcctcctgt acgttctgca atctcagcga ctacatcgtc tgttttagac 602521 ggatcaacga tgatcgcgcc aagctcctca gctttttgct ggcgttcagg agaaagctca 602581 acagcgtaaa tatcagttgc accggcagcc ttcagcgctt caatgacaag aagtccgatc 602641 gggccgcagc cgaatacagc cgctttgtcg cctgctttga gtttgcttga gcggacagcg 602701 tatagagcaa ctgcagaagg ttcaacgagc gcgccttgtt catatgataa ttcatcagga 602761 agtttgaaca aaagctcttc atccacagag acgtattcag agaaaccgcc gcctccgccg 602821 gctaagccga ggaatcccat ttgttcatca aggttgtagg cgccttggtg gccgtgtgta 602881 gcaaaaatcg gctcgactac aacgcggtct ccaactttat aattttcaac gccttctccg 602941 acttcgacaa cttcaccgga gaattcatgc cccattgtga caggtgccgt ttcatttgtt 603001 aatgggtgcg gtttgtcaac cggaataaag atcgggccgc ccagatattc gtgtaaatca 603061 cttccgcaga tgccgcacca tttgactttg atctttactt ttcccggctc cgtttttggc 603121 tcttcgatat gttcaatacg gatatccttt tggttatgcc atcttgctgc cttcatggat 603181 taccactcct ataacttttg atgtgagtaa ttccgcaccg gtcaatatga actgttcaca 603241 aaatcgccat ttttaaaacc aaaaaagaaa tgaaattttt atataatata atctacgttt 603301 ttttgaaaaa aagaaacttt aaagaaaaaa gggtctcgca cactcttttt tctttatatg 603361 agagtatcaa tcgtttacat agctatgaat ttggtttgaa caatacggta atggttcgtt 603421 catattgaat gcgacaacta ctctatcaat aattataact ctaatactgc tattataata 603481 ggataatctt ccatggttta ttttagcaga ggtaactttt ttgactttgt aacattactg 603541 taaggatatt gaaataaaaa atagctggtt gatcgtgtat aatcttccta gatgttaaca 603601 aacaggggga cgaaatgttg aagaaagtca ttttagccgc ttttatctta gtaggaagta 603661 ctttgggagc ttttagtttt tcatcagatg ccagtgcgaa acatgtgaac ggaaatatta 603721 cttggtataa tggagtcggg aaaaaaggct cttcaggtaa gaaacttgga cattgggatt 603781 gtgcgaccaa aatcggattt gatgttccta gaaacgggac aaaaatcaga gcttatgcaa 603841 aagcgaagcc taaaaaggtg attacggttt ataaaaatga tgttggcaga atgcctaatg 603901 cagtgctgga tgttagccct aaagcgttta aagcgcttgg atacccatta agcaaaggta 603961 aagtagcggg gcattacagc tattaatgta catatataat ctggaaagca agaagtcaca 604021 ttcttgcttt ttctattggt ggagataaaa gatgaaaaaa agaatcatat tattattagc 604081 agtgataata gcggcagctg ccgcgggggt tgcgttttat gttgcaaagg ataaaggcca 604141 tgagaaggct gctgatgttt cagtcaatac cgaaagcggt gatgagctgc tggtttcaat 604201 tacagatacg gatctgctga caaagtatta tgaaaatgac aaggtgatcc atgaggagaa 604261 gctgaccagc tatccggcat ttgccttgga tcaaaaacag caggtgctct attatacggg 604321 caataatgaa cagaatgaaa tgaggctttt taaattggat ctgaagtctc ataaaaaaac 604381 gatgctttat aaaggcgcgg agagtgcgga cagtttattt ttatcaaagg accgttcaac 604441 catctatttc cgcttaggaa aagcggacga aagcaatttt cgaatcgccg cttttgatct 604501 gaagacgaaa aagtataaaa atctttatcc tgccgctaat gatcaggatg acaccgtcag 604561 cagcttcttt tataaccaaa aaaacgattc atttgcattg cttcattatt ctgtagaaga 604621 agactacaag aaaacagatg aagcaaacga aaagggcatc gaccctgaac cgacaacgat 604681 tcattttgcg gaaggccgcc aaaataaatt taatgagctg aaaagcctga accaatttat 604741 cagcgatatt gctgtttctg atgatgataa acgtatttta ttcacatcat atacgcaaaa 604801 aggaacggag caaaccgctt ctattcaaat gctcaatgcg gatacgaaaa aatatgaaag 604861 catcatctca aatcaaaaat catttaagct gttaattgac gcacagcctc agttttctaa 604921 ggatgggaag aacatttatt ttcttgccga agccaagggg gctaaaaagc tgaaggacga 604981 aacagggcgt gaagctaagg tgcggacgat ttattcctat agccttgaga ataagacctt 605041 caaaaaagta tgggaaaatc cgaacggcat catcaacagc ttttttgtga ttaactaata 605101 aaaaccactc ggcatgagct gagtggcttt tttaatggat gaggtgcagg gctaatgatc 605161 cgagccattt aaagatatga atcagaggta ccgacaaaaa cagaagttca acatatgagt 605221 tcattgcaac attcagcttt ttgaacgcag ctcttttttt caagtctttt tgctgctggt 605281 ttgagatcac gttatcactc ctcttatatc catattatac cattaaaaca gacaaaaaag 605341 ccctaaacgt ttacagtttt gggcttcttt cttcgtattt ggcctcttgc aatgagaggc 605401 ttttattctg aaatatagaa ttttgtctcc gttcggggtt tgtttgcttg cgggagactg 605461 catttgttat agggaagaac tagcttgttt tcgtttggct gttgttttgg agattcacta 605521 atgaacggat gccgtcgacc attttacttc cgcacaaagg gcacaatggc gtatcactgc 605581 tggcgaagtt ttttcgggtc cagccattac agtcttcttt tgtgcattcc caagtactca 605641 catcttcctt tggcagcggt tcttgatttc gtttgttata gtaagacata aagtcacttc 605701 ttccctcatg tattttactg cacatttcct attgtctcat acttttccct aatctcctaa 605761 ttcctttttc tttatgactt tccaataacc ccatctaaaa aggagaggag tgtgctgtta 605821 aaagcatctg gctcttctaa aaacgggcaa tggctgcttt taggaaaggt aacgagtgtc 605881 gcgtttggaa tattgctgcg caagtgttcc ccagctgctg tagagaaaaa tttcttgtct 605941 tccccgaagc acagcaatgc cggcacattg atgttttgga gggtgccccg gtaatcagcg 606001 gccgtttggt taaataaaat cgtgctagaa atggcagccg gctgtttgag gatttctgcc 606061 agcatccatt ctgtttcggt ctcggcaggc ggttctgcga acatattctg gatgaagctt 606121 tcgtagaaag gcagcgggtc agtttgaatg gcgtgcatcg ctgtttttaa gccgtcaaaa 606181 tcaaatggac catgttccca gccctcccat tgatagtccg aagcggattg atcgatgatc 606241 acagcggctt gaatgttatc attcccaaac tgattgagat aatcccatac gacaaaagca 606301 cccattgacc agccggcaag aacgacatga tcaagctcca ttgcatttag aaattccctt 606361 atgtcacggg catattggga aatggtgtgg ccgtgaagca ctttgtcaga ttcgccgtgt 606421 cctctaagat caagacgaat acattgataa ttggcagaaa gcaccgaaaa ttgtttgtgg 606481 aaaaattgtc cgctcatcag caccccatgt ataaacagga tcggcgtccc gctcccgtgt 606541 gtttcatagt aaaggcgtgt ctgatcttct aatatgatgt atggcatgtt tctcctcctt 606601 tagtttccat catgagtatg gctggctgct gttgagctga tgatggcagc tgtcgcggct 606661 gcctgctgcg cttgaatgac tgtttcgata gcggtgtata gtcctgattc catcagcaga 606721 tttttctcca tatgctcact gagatagagg ctgacagcaa ttttaaagtt catttccttt 606781 tgccatttaa aagctttttc ctggtttaat tcgtcagtga tgcacaaaac ggttttgata 606841 tctggctctt ccagaaatgt gaggagagca aggtctggat aatgataatc ctttgttttt 606901 ttgacagatt cagtgatcga ttgatatatc tgtttgcaag cggaaacaag catttcgggc 606961 tctttttcac tttgcaaggc cagaatatgg ctgacctgat gtaagtactg tcctttttta 607021 aagccgttgg ctgccagcag ttgatagcat gtttccgcct tctgtagcgc ctgcaaacct 607081 tttccgtttt ctccaagcag tacggcaagc ggaacattct gagttgaagt gaggaaataa 607141 tgatttttct tcatctgctg ataaacagct agccccatgt tcatctgttc tttttggttt 607201 gtcgtttcag atttgccggt gagcaagatc agagcggaaa ggtatgtgaa catatcccgc 607261 ttatacccta gcttcaccat ttcattgtat acatcgatga aagtctgaaa tgtttgtttt 607321 gcctcatgct gaaaatgaat gtccagaata gatgcaacag taaagcggtg gtgtgaattg 607381 agtgttgaga agctgccgat gtttgatttg atatagctgc tcaaatcata aaagcgctga 607441 aaatcaaact ctcttttatt cacaatatat gcagaagaaa tgagcattaa tatctgatcg 607501 tgtgaaactt tccattttaa ttttgttttt aattcagcat aaatggaaat gtaatgcttt 607561 gttttttcat gtagatcgtg tgtgagcata aaaagcagct ccttttgttg tttttacgta 607621 atacgataaa tagggccaaa ggtttcataa agaaaaaact tgcctgctag aggcaagttt 607681 gtcgggttat ttatggggat cagttatatc catcggtctc atcatgtcat agtcttcatg 607741 ctctagaata tggcaatgcc atacgtatcg tccgctgtac ggaccgaatg tcgccgcgat 607801 tctcaggact tcacctgcat gcgcttgaat ggtgtctttc cagccctttt cacttggcgg 607861 cggcgggaca gccggaccgg tataggacaa ttccccgctt tcttgataac gggcgatatc 607921 aaacggccgc cggtctaata cacggaagga gactagatgc aggtggatcg gatgtgttcc 607981 gcgtgtcggg ttgataatgg accatatttc agttgtgccg acttttggtg tttctgtgac 608041 gggatcgtgc cagcgtttgt tattaagcag aaggacgggt ctgccgtatt cgtcctgggt 608101 gcctgccagt tttaacgttc tgatgttttg tattctttca tgctgtaccg aagggtatga 608161 ggcgaggtac ttcggctttc tgctttcgtc tttttgtgcc aatggttttg tgactctgaa 608221 ttgcatgata ttcgcatctg tttcaggatt gacgtcaccg ccgcagcccg cgctgtttgc 608281 caaaatgatc gattctcctt catatgctgt gaagtcaatg atgatatcgt aacgttcagc 608341 aggcgcaagg ctgaaagaat tcagtttaac agatcgcggc aggagccctc catctgaacc 608401 aatctgaata aaatctccgc cattatcgag tgacaggtta taggttcttg tattggaggc 608461 gttgatgaca cggaatcggt atttccttgg ctcgacttcc aagtatggcc ataccttccc 608521 gttgacgagt atggtttctc cgcaaaaagc cggaacgatt gaaggattag gcagtgacgg 608581 agaagggttt tccggtgcgc tcggataaaa caaagaacca tcctcattga tcgtgcggtc 608641 tgtgataaga agcggcacat cgtattcgtc tgaaggcagt tttaagcgtt tttcctttgg 608701 gtcatgaatg atatatgcac cgacaagtcc ggcatagaca tttagcctgg tgagcgccat 608761 ggcgtgatcg tgataccaca atatagcccc gcgctgctgg tttggataat gataaacctc 608821 tcttttgaaa taaggtcctg tttgttcaaa gtctttggaa aaccaagcct ccggataccc 608881 gtcactatca tctggcgtga cgccgccgtg taaatgaaca acagtcttta cctcgggctc 608941 ttcatgctgg ctgtcactgt gatgaatggt gtgatcaatc ggaaggaaat gcgtggaagg 609001 aaggttattc atccatttta catatacgtt ttcatttctt ttaacctcaa tggtcggtcc 609061 cggaaataag ccgttgtagc cccacaggcg ggttggaggg agatcgcgat ggagctgatg 609121 agtgcattcc tccatggtga cttcgtagta tgttttttct tttgattgct gtactggctt 609181 tagtgtatct gggattggga gagcatccac aaatttttca agtgtcattt tcatctgtcc 609241 ttatctaaat tttccaaatt ggtactatag ttaatgacaa taaggacgtg atggttacaa 609301 aaaatcttcg tgctgcagcc cgcccgaaga agaaaataac aaaatcctaa acggcaggcc 609361 gtttaggatt tgatcagcat taaggcagga tatcgggttg ctgctgtgtg actgggttgg 609421 cagccgcttt ctcgctcacc ttgcgttttc tgaacacaag gtaagaaatc agaacgattc 609481 ccgtgatgac gcctgtcagc agcagctcgt ctctcatgga atcaataaac gccatggaca 609541 ctaaaattcc gcaaatggcg atgatggtca agtaggttag gaaagggaag agccacattt 609601 tgatcttcaa tgcttctggg tttgtttttt cgagtttttt ccgcattttc agctgggaaa 609661 cggcgatgac aagatagacg agtaaagcga ttgcgcctga tgagttgact aagaataaaa 609721 agacggtatc cggtgaaaaa tagttcatta cgaccgcgat ataagagaaa aatgtcccgg 609781 ccacaatggc ttgtacggga acgccttttt tgctcaattt cataaaacgg cgcggcgctt 609841 catttctttc tgcaagtgaa tacagcattc tggatgtggt atacaaacct gaattcaggc 609901 aagagagtac ggctgtgagg acgataaagt tcataatctg tgcggctgcg ggcactccta 609961 tatgctcaag tacagcgacg aaagggcttt ctaaaatatt tgctgaattc catggcaaca 610021 gcgccacgac aatggcgatt gagcccacgt aaaagacgat gatgcgccat acaacggatc 610081 tggtggcttt tgtcacagat tcgatcgggt tggatgtttc ccctgctgca atggcaacga 610141 tttcagttcc cataaaagag aagatgacaa cgacaatgcc gagcaatacg gagctgatgc 610201 cctccgggaa aaatccgcct ttgcctgtaa gattcgaaaa accgactggc tcactgcccg 610261 gtgcaaagcc aaaaataaag gcaaaaccaa cgattagaaa agcaatgata gtcacaactt 610321 taatgaggga gaaccaatat tcaaactcac cgaaagactt aacggagtag acgtttgtca 610381 gggtgagcac aatggtcaag atcaaacttg tcagccacag cggaatatca tggaaccagt 610441 attgaataat gccagcaccg gcaatggctt cgatcgctat gacgatcacc cagaaaaacc 610501 agtacagcca gccgattgta aatcctgccc acggtccgat ggcgtcgtga gcgtattgag 610561 aaaacgatcc gctcgtcggg tttacggcag acatctcacc gagcattctc ataataaaaa 610621 tcaccaataa tccggctaac gcgtaagaaa caacggcacc cggaccggtc gagtgaatca 610681 ctgaaccgct gcctacaaat aggccggctc cgattacacc ggcaatcgaa atcattgtca 610741 tatggcgggt ctttaattcc ttttttaatc ctgattgaga ctggttcata agttacctcc 610801 ttttaaaatg caatcattac tgaatattat gataattgaa actctatcat aaatatacag 610861 tttgtcgaaa attcgtgtaa gaaaatatac cagcttattt caaatttgta gtgttttgtt 610921 tgcgctttca gcgaatgtgt ggaaaaaatg tttcgttttt tattcgctgt gtgattttgc 610981 gtaatattta caattcgata gaatgcgaga agcactggtg tccttgggtt tgatgggatt 611041 tttggcggag caaataaatt ggatgagaga aaaagtgttc cttcgtcact atttttctgt 611101 ggcgggtgaa tcatgtttct gtagacccac tgcggatcag ctttgtaaga taataatagg 611161 aaaatgtgag cgagaggagg ttttgtatgg agagatatga tgaactgaaa aagggagaat 611221 ccggagcgct ggtcagcatt gccgcgtatc tagttctttc cgcaattaaa ctgatcatcg 611281 gttatctttt tcactcggaa gcacttacgg cagacgggtt aaataacaca actgacatta 611341 ttgcttctgt tgctgtgctg attggcctgc gcatctctca aaagcctcct gacgaagatc 611401 atccatacgg ccactttcga gcggaaacga ttgcatcgct tatcgcatcg tttattatga 611461 tggttgtcgg actgcaagtg ctgttcagcg ccggagaatc tattttttct gctaaacaag 611521 agacgccaga tatgattgcg gcttggacgg cagcgggcgg ggcagtcctg atgctgatcg 611581 tttaccggta caataaaagg ctggccaaaa aggtgaagag ccaggcgctc cttgctgcgg 611641 ctgctgataa taaatcagac gcattcgtca gtatcggcac atttatcggc attgtggctg 611701 ctcaattcca tcttgcttgg attgatacgg tcactgcgtt tgtgatcggt ctgcttattt 611761 gcaagaccgc atgggatatc tttaaagagt catctcactc tttgacagat ggattcgaca 611821 taaaggacat ttccgcttat aaacagacaa tcgaaaaaat ctccggtgtg agccgtttaa 611881 aagacataaa agcaagatac ttgggcagta cggttcatgt tgatgtggtg gttgaggtat 611941 cggcagattt aaatattacg gaaagccacg atatagccaa tgaaattgag cggagaatga 612001 aggaggagca tgcgattgat tattcgcatg ttcatatgga gcctttagaa caaaaataat 612061 ggagcttcct gtcacaggaa gcttcagcgt gtcgacaaac cctcgcattc gttgtcaggt 612121 ctgcgcttcg gtgctcacga attagaacat tcgctccgct cctatgctcg tccttcctag 612181 acttcaaggg ttttcaatca cgctgaaaag atgacaaaac cctaaaatga aagccatttt 612241 aggattttgt caacaatctg gagcttcctg ccacaggaag cttttttgtg tgttttggcc 612301 agctttattg gtaacaattt gctagaatcg tttttttata cagattgctt tttgtggtaa 612361 agttaggtta cattatgatg aattttgtag atgactagga ggaaaataat ggcatatcaa 612421 gaagacctgc atcctttgct ggggaaagca gttgaacata ttaatagagt aatggttgga 612481 aaacgagaca tcgccatact cagcttagca gcccttcttg ccaaagggca tgtgctgctt 612541 gaggatgtac ccggagtcgg aaaaacgatg atggtccgcg cgctggcaaa gtcaatcggc 612601 gccgatttca aaagaatcca attcactccg gatttgctgc catctgatgt aacaggggta 612661 tctatctata atgcgaaaac gatggaattt gaatatcgtc ccggcccaat tatgggaaat 612721 atcgtgctgg cagatgaaat caaccgtacc tctccgaaga cacagtcggc tttgctcgaa 612781 gcgatggaag aggggagcgt cacggtagat ggccatacga tgcagcttgc cgatccgttt 612841 tttgtgatgg caacgcaaaa cccggtcgaa tatgaaggga cctatccttt gccggaagct 612901 cagcttgacc gttttttatt caaacttcgg atgggttatc cgtcctttaa tgaagagctt 612961 gacgtcttat ctcttcagga aaaaagccat ccgattgaga cgcttgagcc ggttattgca 613021 aaagaagact tcatcttttt acagagggaa gtgcaaaatg tccgtgctga tgacagcatt 613081 aaggaatata tcgttgaaat tgtgcagaaa acgagacagc atccttctgt tcaattaggc 613141 gtcagtccgc gcggctcaat cgccctcatg aaagcggcac aggcatacgc gctgctgcat 613201 catcgcgact atgtcatacc ggatgatatt caatatttag ctcctttcac gctgccgcac 613261 cggatgatgc ttcatcctga ggcaaaattt gaagggattc aggcagaagc gatcgtaagg 613321 gagatcatgt cagctgtgaa ggtgccggtt caaaggtcgg cggtccgctg atgaataaga 613381 aatggcaatg gctcgtatat ggttggaagc tgattatatt aactttattg acggctgctg 613441 ttttttctta tgcgatgttt cagggcggct ttgtcagctg gtttttgttt tacgcgtttc 613501 tcccttttgt cttgtatgcc gggctgttgg ccttgtatcc gctccgttct tttcaggctt 613561 caaggcaaat ggataaaaca caattgcatg cgggggacag gctgggcgta acggttacgc 613621 tgagaagaaa gctgccattt ccgctgatgt atatggtgat tgaagattgc ctgccagaag 613681 gtatcgagtc attaaatcga gacggagccg cggccaaacg gctcgttttt ccttggttta 613741 aacggagcat gacgatgtcg tatgaattag ctcgggtacc gcgcggagag catcactttc 613801 attctgtcag ggtgcgaacc ggggatgttc ttggcttgat tgaaaaaaca gcattttttg 613861 agctggatga taccttgttt gtttatccat tctatcagcg tttttcctat caggtgaatg 613921 agaggcatca ggaagacggt gtaagcggtt cttctcctat tcatcagcac cattcctcag 613981 tcgcagcaag tgtgcggaat tatcagccgg gagaccggtt tgctgcgtta gattggaaga 614041 catctgcacg gcggagccag ctgatgacga aggaatttga gccttctcgc agcaaaaatc 614101 tgtttctgct gatggaccgt ttttcctcag acgcattcga agaggtcgtt tcagtgacag 614161 cttcgattct tcattctgtt ttaaaaaacg gcgcgggtgc tggtctggct tccatcggga 614221 aggaaaaaaa cattttccct attcaggaag gggatcagca ttttaagcac atgcttcggc 614281 atttagccat cgctcattgt gatgcggcag acccgataag ccgatatgca cgggaagagc 614341 tgggaaagcc atctgttcgc caagctgatc aagttgttgt cacgggacag ttaacggaag 614401 atatgctgca cctcgcagaa ataggaggcg gccgggttac ggtgatactg gcaaaagaga 614461 aagatgctga gctctctcaa gctgaaaatg tcatgattga acgcatgatg aaacgccaaa 614521 tcagagttcg gatcatgagg ggcgggcgag tttcgcgtgt tgtttagaaa gagaggtgac 614581 tggttcacat gccgcacgat gatcacaagg gaagccgttt gagcttgctg ttattttatt 614641 ttctggcttt tttattgctg tgggagtggc ttaggccgct tgacagtttt actgaaacga 614701 aacatacagg cttttttagt gtctttatcg gcttgacgtt tctgctgact tttttcagga 614761 tgaggtggtt tgtcaccgtt cctttttgtg tcatatttac attgatctcg atacacatcc 614821 tgttttatca aggatctata ttcgacttga gctgggtcag ctcttttttg caggatgtct 614881 atctgaatat cacgctgatt caatcagggc aatggaatga catgattcct tcatttcgga 614941 ccctgctgtt ttttgtgctg ctgtggctgc tggtctatct cctgcattat tgggtgattt 615001 accagagaag aattttgttt ttctttttga tgacagtagc gtatattacg attcttgata 615061 cctttacgcc atatgatgcc acttttgccg taatccgtat cgtgctgatc ggcttcttta 615121 tgctgggcct tttatacttg gaacgcatta agctgatgga aagaatcaca ctgccaaaaa 615181 catctgtcct gaaatggttt cttcctttat ctgtattggt tttggctgca acgggattcg 615241 gactcgccgc tccaaaatca gagccggctt ggcctgatcc ggtgcctttt cttaaaaaaa 615301 tcactcatca agaccgcgtg tctgcagggg aaagcaaaat cggatacggg aatcatgatg 615361 aatcactcgg cggcccgttc cagcaggatg ctacacctgt ttttacatgg cagggaaaag 615421 agcgtacgta tttccgtgtg gaaacgaagg acacgtatac cggaaaaggc tggattgaaa 615481 cagacacagg catgtcgtat cagcttagca atggaaaagt tgaaaatctg tggtttgacc 615541 ataaggttgc gacagagcgc cgcaccgtcc gtgtaaaagt cgataagcac tacgggtata 615601 accatctgat gtatccgatt ggtgcggaaa ccattcagcc aaagcaggct gtctcacttg 615661 aaatgaacgg caacacggag caaatttctc cgatcagtga acaagccggt gaaatcagaa 615721 atatggggaa ttatacagta acgtacaatt ccccggtcta taagctggat gaactgagaa 615781 aggtaaaagt gagaaaaaac agtgaggagt acacattcag cgatcgctac atgcagcttc 615841 cagattcact gccagagcgg gtgagaaccc ttgcgatcaa actgactcag gatcacgaca 615901 atatgtttga taaggtgaaa gcggttgagg actatttagg gtcaaatgcg ttcacatatg 615961 aaacagaaaa cgtgaccatt ccgaagaatg atgaagatta tgtcgatcaa tttctctttg 616021 aaacgaaaat gggttattgt gataactttt cttccgccat ggtggtgctc ttgcgctcgg 616081 ccggcattcc ggcccgctgg gtaaagggtt atacgtccgg cgaatacaaa gaagcaggga 616141 acaaaaatgg cagcatttac gaagtgacaa ataacaatgc ccattcctgg gtagaggtgt 616201 atttcccgga acagggctgg gttacatttg agccgactaa agggtttaca aatccggctc 616261 aatttacatc ttctgacaca aaagactctg gcagcgatag cagcagctcg ccgaagaaag 616321 caaaagagaa acagaaagaa gagaaaaaac agccgcaaaa agaggaaaaa caaaaggaaa 616381 agcgggagcc agctgtttct aaaaagccgt ccgcttcgca tactaatgcc ggtgcgggct 616441 tgtatgcagc gcttgcggtt cttgcagtcc tcctggtggc agctgtattg ctgtatgttt 616501 tccgctcgtt atggattcct gttttcgccg tgaggaaatt gaagcggcgc agtgatcagc 616561 acgcgttttt tgaggcatat ggcgcgctgc tgaaacaact gaagagaaaa ggactgccga 616621 aacgagacag tgaaacgctg cgtgattatg caaaacgaat tgatgaaaaa tacgacatag 616681 aagacatgtc aaagctgaca ttaagctatg aaagggcgct ttacagaaat gaagattctt 616741 cggcgctatg gaatgattcg agagagttat gggaaaattt aattaaaaga agatggtctt 616801 gaccgcttat cgacgtgttg ttagaattag tgaatattat cggagtctgg gagcgagttg 616861 gcctgactcc ggcaaacggc cttgccaaag agggcggagc gagcttcata tctgtcctcg 616921 tttttttctg tgtcaaaaaa cttagaggag attaggtgac aaccatgaca aagttagtga 616981 atgaaatgat tcttgtcctt gatttcggca gtcagtataa ccagctgatt acacgccgta 617041 tccgtgaatt cggtgtttac agcgagctgc atccacatac attgacggct gaagaaatta 617101 aaaaaatgaa tccaaaagga attattttat ccggcggtcc aaacagtgtg tatgatgaaa 617161 actctttccg ctgtgacgag aaaatcttcg agcttgatat tcctgttttg ggaatttgct 617221 acggcatgca gctgatgact cattaccttg gcggtaaagt tgaagcggca agccagcgtg 617281 aatacggaaa agcaaacatc cgcatcgaag gcacacctga tttgttcaga gatcttccga 617341 atgaacaagt ggtttggatg agccacggcg atttggttgt agaagttcct gaaggcttca 617401 ctgttgacgc gacaagccat cactgcccga actcagcaat gagcaaagcg gacaaaaaat 617461 ggtatggcgt tcagttccac ccggaagtgc gccactctga atacggcaat gatcttctga 617521 aaaactttgt attcggtgtt tgcgaatgcg aaggcgaatg gtcaatggag aactttatcg 617581 aaatcgaaat gcaaaaaatc cgtgaaacgg tcggagacaa acaggttctt tgcgcgctaa 617641 gcggcggcgt tgattcctct gttgttgctg ttttgattca taaagcgatc ggcgaccagc 617701 tgacttgtat ctttgtagac catggtcttc tccgtaaagg cgaagctgag ggtgttatga 617761 aaacattcag cgaaggcttt aacatgaatg tgattaaagt agacgcaaaa gatcgattct 617821 taaacaaact aaaaggcgtt tctgatcctg agcaaaaacg caaaatcatc ggtaatgaat 617881 tcatttacgt gtttgatgat gaagcggaca agctcaaagg catcgactac cttgcacaag 617941 gtacgcttta cacagatatc atcgagagcg gtacagcaac ggcgcaaacg atcaaatctc 618001 accacaatgt cggcggactt cctgaagaca tgcagtttga gctgatcgag ccgttaaata 618061 cgctcttcaa agacgaagtg cgcgcgcttg gcacagagct cggcattccg gatgaaatcg 618121 tatggcgtca gccgttccca ggaccgggac tcggaatccg cgttcttggc gaagtaacag 618181 aagaaaaact tgaaatcgtt cgtgaatcag atgcaatctt gcgtgaagaa attgcaaatc 618241 acggcttaga gcgtgatatc tggcaatact tcactgttct tcctgacatc cgcagcgttg 618301 gtgttatggg tgacgcaaga acatatgatt acacaatcgg aatccgcgcc gttacatcaa 618361 tcgacggcat gacatctgac tgggcgcgta tcccgtggga tgtgcttgaa gtcatttcga 618421 cacgtatcgt aaacgaagtg aagcacatta accgcgtggt gtatgatatt acaagtaagc 618481 cgcctgcgac gattgagtgg gaataagaat caattaatgg aaaccatctt tttggcaatt 618541 ttgccgggaa gatggtttta tttgtttatt acgaacaaaa tccgattttg cgcgactatt 618601 gttcgctttt tgtattgttt tttcaaaatg aacttggtac aatagacaca gaaatcaaat 618661 aagatgaatt cgtataatcg cgggaatatg gctcgcaagt ctctaccaag ctaccgtaaa 618721 tggcttgact acgtaaacat ttctttcgtt tgatataaat aaaacacggt tatttattca 618781 aactgaaatc cgtctgtagt caagcgtccc aaaatgtatt gggacgtttt ttatttggcg 618841 ttttcaggac agaataaata gcaaagagtg aagggagtca aatagcttga aaacgttttt 618901 tcagtttgat gagctgggca ccagctatcg caatgaaatc attggcggat taacgacttt 618961 tttatctatg gcatatattt tgttcgtcaa tccgattacg cttgctttgg agagcgtgaa 619021 agattttccg gaggcgctga gaattgacca gggtgcggtc tttacggcga cagcgctggc 619081 gtctgcagca ggctgtatct taatgggatt aatagcgaga tatccgattg ccatcgcgcc 619141 gggtatgggg ctgaacgcgt tttttgcgtt ttctgttgtc cttggtatgg gtatttcatg 619201 gcaggcagct ttgtccggtg tttttatttc aggtcttatt ttcgttgctc tttctttaac 619261 aggttttcgt gaaaaaatca tcaacgccat tccgcctgag ctgaaattgg cagtcggtgc 619321 ggggatcggc ctgtttatta catttgttgg attacaaggt tcaggaatca ttacagcgaa 619381 tccttctacg ctcgtcacga tcggaaacat tcacagcggt cctgtgctgt taacgatttt 619441 cggtgtgatt gtcacggtta ttttaatggt gcttcgcgtg aacgcaggcg tgtttatcgg 619501 gatgctatta acagcggtag ccggcatgat tttcggtttg gttccggttc cgactcaaat 619561 tatcggcagt gtgccaagcc ttgcgccgac tttcggacaa gcgtggattc acctcccgga 619621 tattttctct gtacaaatgc tgatcgttat tttaacattc ttgtttgtcg gattttttga 619681 tacagctggt acacttgttg ctgtggcaac acaagctggt ttaatgaagg aaaacaaatt 619741 gccgcgtgcg ggccgtgcgc ttttagctga ttcatcttct attgtgatcg gtgccgtgct 619801 tggtacgtct acaacaactt cttacgtgga atcaagctca ggtgtcgctg cgggtgcccg 619861 gtcaggattt gccgcaattg taacagggat tctcttttta ctggctacgt ttttctcgcc 619921 gctcctatca gtcgttacgt caaatgtaac agcgccggcg cttattattg ttggtgcatt 619981 gatggtggcg ccgcttggca aaatcgcttg ggataagttc gaagtggccg ttcctgcttt 620041 ccttaccatg atcatgatgc cgttaacgta cagcatcgcg actggtattg ccatcggatt 620101 tattttctat ccgattacaa tggtgtgcaa aggaaaagca aaagaggttc atccaatcat 620161 gtacgggctg tttgtcgtat ttatcctgta ctttatcttc ttaaaataag gaatgaaaaa 620221 ccagctgcac tggcagctgg tttttttgtt gcaaaagata aaaccatttc atacgatata 620281 ccgtcatgta gatgtgccgc catgctttac ttaaatggaa atgacttgac tgttcaggaa 620341 ggcttcggta ccttatataa gtgttttatt ttcttgctga atggtattcc gccgtatttt 620401 tttgatagga gttgctgaca tgacggaaga aagaaaagaa acgtttgaag aagaaattaa 620461 ccagagtgaa agaatagatg cagatgaaga accgctatcg agaatgtcca gaaaggcgag 620521 ccggcaaagc aagcagaagc aaaaacaaaa gcagaaaccg cgccaggaac gcggtgaatc 620581 aactgttaaa gacaagcttg cgtctgtttg ggcagccatc aacagatatt gcggttttgc 620641 gttctcgatt ttaaaatctc cggcgaaaac tgtcgtaacg gatggttttt ctcattataa 620701 gtacggtctg atttcaatgc ttatattcag tatcattttt tcaattggga attggtttca 620761 gttaaaggca agctggaatc ggccgctcgg tttcggagaa cgccatcatg ctttctatga 620821 cgggttttta gttgttcttg tgtatttgct gatctttttc gcggtaatgg tctttgctat 620881 atgggctgtc tcccgctata tgatgaagca gaaggtgacg ttcagagaag cggctgccgt 620941 attgggttca ttgcttgtac ccgtaattgc tgtttcaatc ctttggctga tctttgcgat 621001 cgtaaatatc ccaatgctga cagtactgtt tacggtgctg atcttgtttt ccatcttttt 621061 tatcatcgcg ctgtatgtac agcgtgtgta ccaggcggca caagatgcac caattgatta 621121 tatctattgt gtatttgcag tagttgcgat agcgctgctg tttacggcag tgacttggcc 621181 gtttatttct gaatatatta cggcgtcgtt gattccgctt taatgaaaaa accggctaat 621241 cctagccggt ttttttatgt cacacttttt acaaatatat ctaaaaaaca tagttgattt 621301 gtaggattaa cccgtgtatg atggggaaaa tgctgaaaac gtccagcgca aaaaccttta 621361 tgtttaagga ggatgatgga catggctgat gtacttcgcc gagcaattaa ccaaaagaag 621421 caatttttaa aaaccaaatt actgctctcg gaattttatc aaggaagagg ggaacagctt 621481 gctgactaca cgctgagtga gcttgagaaa gaatacaagt cccttcagaa aatgaaaaaa 621541 gagatctgac aatagatata aagaggtgag tctgctgaaa agcgggcttt tttgttttga 621601 ttttgaaaag gcgagaaaga gggtaaacta ctactgttca acacataaaa gcgtgtcgaa 621661 atattttgct taagcttacg ggcgaagctg attgtaaacg gctcatttct ctagtagaat 621721 atgaatgctt tgtgcaagct gaagagtagg gggatgaata aaatgatgca aaccatctta 621781 tcaaatggga tagccatggt tctcataatt ctcattatta atattgtcta tgtgtcattt 621841 tttacgataa gaatgatttt aacgctgaaa ggacagcgtt atttagcggc cggcatcagt 621901 acgattgaaa tactggttta tgtgacagga ctgagtctgg tgctcgataa cttagaccag 621961 attcaaaatg tgatcgcgta cgcgctcggt tacggtcttg gcgtaattgt cggcatgaaa 622021 atagaagaaa aattggcgct tggctatatt atggtcaatg tgattacgaa ggagctcgat 622081 cttgatcttc cgaagcagct ccgtgaaaaa ggctacggcg tgacaaactg ggtggcaggc 622141 gggcttgaag gcgaccgcac agcccttcag atcctgacgc cgagaagata tgaactccag 622201 ctatatgata cgattaaaac acttgattca aaagccttta ttattgcgta cgaaccaaaa 622261 acaatccacg gcggcttctg ggtcaaagcg gtgaagaaga ggagaattaa agaataatgg 622321 caaagccgaa gaagaaaaag tttgaagtga cagagcagca aacgattgat gcggtgcttc 622381 agcaaatgaa agaagaagga tatctgcctg taaggcgaat ggaagagcct atttttatgg 622441 aaaaaaagga aaatgggtca attcagatcg ttccgtgcgg gaaaaaaatc gtatttgaag 622501 ggaaattgat ctaaaacacg aacattagta gaatgaattt ttgtatcgtt cgataatatc 622561 gttgacatta tccatgtccg ttgttaagat aaacatgaaa tcaaaacacg acctcatata 622621 atcttgggaa tatggcccat aagtttctac ccggcaaccg taaattgccg gactatgcag 622681 gaaagtgatc gataaaactg acatggatat atcgcagaag cgaacgactg acgatacatg 622741 taccatgccc ggtttgtatt gcttcctcat aagtgcaatg cagagcgggt attttttatt 622801 ttctgaaaac aaaagcatta gaaggtgggg aacagaatgc agccgctagt aggaatcatc 622861 atgggaagca cttccgattg ggagacaatg aaacacgcat gcgacatact tgacgaactc 622921 aatgttccgt acgaaaaaaa ggtcgtttcc gctcaccgga cgcctgattt catgtttgaa 622981 tatgctgaaa ctgctagaga aagaggcatc aaggtgatta ttgccggtgc cggaggagcg 623041 gcgcatctgc cagggatgac ggctgcgaaa acaacactgc cagtcattgg agttccggtt 623101 cagtccaagg cgctgaacgg aatggattca cttctttcca tcgtccaaat gcctggaggc 623161 gtgcctgttg cgacaacatc catcggcaaa gcgggtgctg tgaacgcagg cctgttagcg 623221 gcgcaaattt tgtcagcatt tgacgaagac cttgcccgta agctggatga gagaagagaa 623281 aatacaaaac agacagtgtt agaaagcagt gatcagcttg tctaaacaaa tcatctatcc 623341 gggagctgta atcggcatta tcggcggcgg ccagcttggg aaaatgatgg ctgtgtccgc 623401 caaacaaatg gggtataaag tcgcggtcgt tgatccggtg aaagattcgc cgtgcgggca 623461 ggttgcggat gtcgaaatta ccgctcatta taatgaccgt gaagcgattc gaaaattggc 623521 tgaaatcagc gatatcatca catatgagtt tgaaaacatc gactatgatg cgctgcattg 623581 gctaaaagat catgcgtatc tcccgcaagg aagtgagctg ctgcttatta cccaaaaccg 623641 tgaaacagag aaaaaagcaa ttcaatccgc gggctgtgaa gtcgcaccgt acagcatcgt 623701 caaaacaaag aatgaattga aacaggcagt acaggagctc aggcttccgg cagtgctgaa 623761 aacatgccgc ggcgggtacg acggcaaagg ccaatttgtg ataaaagaag aggcgcaaat 623821 ggagcaggca gccgctctgt tagaacacgg aacttgcatt cttgaaagct gggtttcttt 623881 taaaatggaa ctgtcggtga tcgtcgttag atcggtaaac ggtgaaattt caacatttcc 623941 gacagctgaa aacattcacc acaacaatat tcttttccaa agcatcgtgc ccgcacgggt 624001 agagaaaggg attcagcaga aggctgctga tctcgcagtt aagcttgcag atgagcttaa 624061 ccttgtcgga ccgcttgctg ttgagatgtt cctgacagag gacggagagc ttttggtcaa 624121 tgaactggcg ccaagaccgc acaattcagg gcattatacg ctggaccttt gcgagacgag 624181 ccagtttgag cagcatatca gagcggtatg cgggcttccg cttgggaaga cagatttgct 624241 gaagccgggc atgatggtga atcttctcgg cgatgaagtg aagcttgttg aggaagaccc 624301 ggagctttta aaagaggcaa agctatatat atacggaaaa catgaaatca aaaaaggccg 624361 caaaatgggg catattacat ttatgaagca gcctgaagac gaatggattc aggagatcac 624421 aaataaatgg atgaatagag acggaggaca agcagaatga tcgaacgtta ttcaagacct 624481 gaaatgtccg cgatttggac ggatgaaaac agatttcaag catggttaga ggttgaaatt 624541 cttgcctgtg aagcgtgggc ggagcttggc gtcattccga aagaagatgt aaaggttatg 624601 cgcgaaaacg cgtcatttga catcaaccgc attttagaaa tcgaaaagga cacgcgccat 624661 gacgttgtcg cttttacgcg cgctgtatcc gaatcactgg gcgaagaaag aaaatgggtg 624721 cattacggct taacgtcaac tgacgttgtt gatacggctc tttcctactt attaaaacag 624781 gcaaacgata ttttgctcaa ggatcttgag agatttgttg acattataaa agaaaaagcg 624841 aaagaacata aatacacagt catgatgggg cgcacacacg gcgtacacgc tgagcctaca 624901 acattcggct taaaacttgc gctttggcat gaagaaatga aacgtaatct tgagcgcttc 624961 aaacaagcga aagcaggcat cgaggttgga aagatttccg gtgctgtcgg cacatatgcg 625021 aacattgatc catttgttga acaatatgtc tgtgagaagc tcggattgaa agcagcaccg 625081 atttccactc aaacccttca gcgtgaccgc catgctgact atatggcaac acttgctttg 625141 atcgcgacaa gcatcgagaa attcgctgtg gaaatccgcg gactgcaaaa gagtgaaaca 625201 cgtgaagtag aggaattttt cgcgaaaggg caaaagggtt catctgcaat gccgcataaa 625261 cgaaatccga ttggctctga aaacatgaca ggcatggcgc gcgtgatccg cggctacatg 625321 atgacagctt acgaaaatgt tccattatgg catgagcgcg atatttctca ttcttcagca 625381 gaacgaatta ttcttccgga tgcgacaatt gcgctgaact acatgctgaa ccgcttctcc 625441 aacatcgtga agaacttaac ggtcttcccg gaaaacatga agcgcaacat ggaccgcact 625501 ctcggcctta tctattctca gcgtgtgctc cttgctttga ttgacacagg cctgactcgt 625561 gaagaagcct atgatacagt tcagccgaaa gcaatggaag cgtgggaaaa acaagtgccg 625621 ttccgcgagc ttgtggaagc ggaagagaaa atcacgtcac gtctttctcc agaaaaaatt 625681 gctgactgct ttgattacaa ttaccatctg aaaaatgttg atctgatctt tgaacgttta 625741 ggtttagcat agaagaagct tttagcggct tcttctaagc cgccgcagtt tgaaaattcc 625801 caacattcgg gttaggaggc cttccgtgaa tattgtgaag aatgaacttt tatacgaagg 625861 aaaagcaaaa aagatctaca aaaccgatga cgaaaacacg ctgtatgtcg tgtataaaga 625921 ctccgccact gcctttaacg gcgagaaaaa agcagaaatc agcggaaaag ggcgcttaaa 625981 taatgaaatt tcaagcctca ttttcaaaca ccttcatgct aagggcatta acaatcattt 626041 tatcgagcgc atttcggaaa cggagcagct cattaaaaag gtaacgattg tgccgcttga 626101 agtcgtggta agaaatgttg tggcaggaag catgtccaaa cgtctcggca ttccagaagg 626161 cacggagctt gagcagccga ttatcgagtt ttactacaag gatgacgcgc tgggtgatcc 626221 gctcatcaca gaagatcata tttggctttt gaaggcggcg actcctgagc aggtagaaac 626281 cattaagtcc attacaacaa tagtaaatga agagcttcaa agcatcttcg acgattgtca 626341 tgtcagatta atagatttca agcttgaatt cggtttagat gcagaagggc aagtgctttt 626401 ggcggatgaa atatctcctg acacatgccg cttgtgggat aaagaaacga acgaaaagct 626461 ggacaaagat ttattcagac gcaatctggg aagcttaacc gacgcatacg aagagatttt 626521 caatagactg ggaggcattc atcatgtata aagtaaaagt ttatgtcagc ttaaaagaaa 626581 gtgtactaga tccacaaggg agcgctgtcc agcatgcctt gcacagtatg acttacaacg 626641 aagttcaaga tgtgcgcatc gggaaataca tggagcttac cattgaaaaa tctgaccgtg 626701 atcttgacgt gctagtgaaa gaaatgtgcg aaaaacttct tgcgaacaca gtgattgaag 626761 attatagata tgaggttgag gaggtagtcg cacagtgaaa tttgcggtga ttgtgttacc 626821 cggctccaac tgtgatatcg atatgtatca tgctgtaaag gatgagctcg gccatgaagt 626881 ggaatacgtc tggcatgagg aaacaagcct tgacggcttc gacggcgtgt taattccggg 626941 aggattttct tacggcgatt acttaagatg cggcgccatc gcccgatttg cgaatattat 627001 gccagctgtc aaacaagcag cggctgaagg aaaacctgtt cttggcgtct gtaacggatt 627061 ccagatttta caggagcttg ggctgctgcc aggcgcaatg agacgcaaca aagatctgaa 627121 gttcatttgc cgtccggttg aattgattgt tcagaacgac gaaaccttat tcacagcttc 627181 ctacgaaaag ggagaatcga ttacaatccc ggttgcccat ggtgaaggga atttctactg 627241 tgatgacgag acgcttgcta cattaaagga aaacaatcaa attgctttca catacggctc 627301 taatattaat ggaagtgtca gcgacattgc cggtgtcgtg aatgagaaag gcaatgtatt 627361 aggcatgatg cctcaccctg agcgcgcggt cgatgaactg cttggaagcg ccgacggtct 627421 taaattgttc cagtctatcg tgaaaaattg gagggaaact catgtcacta ctgcttgaac 627481 caagtaaaga acaaataaaa gaagagaaac tgtatcagca aatgggtgtc agtgatgatg 627541 agtttgcatt gatagaatcc attcttggaa gattgccgaa ctacacagaa atcggaattt 627601 tttctgtcat gtggtctgag cattgcagct ataaaaactc aaagccgatt ctgcgtaaat 627661 tcccgacaag cggcgagcgt gtgctgcagg ggccggggga aggcgccgga atcgttgata 627721 tcggtgataa ccaagcggtt gtgttcaaaa ttgaatcaca taaccaccca tcagctctcg 627781 agccttacca aggcgctgcg actggcgtag gcggaattat ccgtgatgta ttctcaatgg 627841 gtgcacgccc aatcgctgta ttgaactctc ttcgatttgg tgaactgact tcaccccgcg 627901 tgaagtactt gtttgaagaa gtagtagcgg gtatcgccgg atacggcaac tgtatcggca 627961 tcccgacagt cggcggagaa gtgcagtttg acagcagcta tgaaggaaat ccgctcgtca 628021 acgcaatgtg cgtcggttta atcaaccatg aagacatcaa aaaaggccag gcaaagggtg 628081 tcggcaacac agtaatgtac gtaggagcga aaacagggcg tgacggcatc cacggcgcta 628141 cgtttgcttc tgaagaaatg tcagactcgt ctgaagaaaa gcgttctgct gtccaagtcg 628201 gcgatccgtt tatggagaag cttttgcttg aagcatgtct ggaagtcatc caatgcgacg 628261 ccttagtcgg cattcaggat atgggagctg ccggtttaac aagctcaagt gcagaaatgg 628321 caagtaaagc cggttctggc attgaaatga atcttgacct gattcctcag cgcgaaacag 628381 gcatgaccgc gtatgaaatg atgctttctg aatcacaaga acggatgctt ttggttattg 628441 agcgcggacg tgagcaggaa atcatcgata tttttgacaa gtatgatctt gaagcggttt 628501 ctgtcggaca tgtgacagat gataaaatgc ttcgcctgac acataaagga gaggttgtgt 628561 gcgagctgcc tgttgatgcc ttggcagaag aagcaccggt ttaccataag ccttctcaag 628621 agcctgctta ctatcgcgag tttttggaaa cagacgttcc ggctccgcaa attgaagatg 628681 cgaatgaaat gctgaaggcc cttcttcagc agccgacgat tgcgagtaaa gagtgggttt 628741 atgatcagta tgactacatg gtgcgcacga atacagttgt cgctcctggg tctgatgctg 628801 gtgttctcag aatccgcgga acgaaaaagg cgctggcgat gacgacagac tgtaacgcgc 628861 gttatctcta tcttgatcct gaagtcggag ggaaaattgc tgtcgctgaa gcagcgcgca 628921 acatcatttg ctcaggcgca gaaccgcttg cggtgacaga taaccttaac ttcggaaacc 628981 ctgagaagcc ggaaatcttc tggcagatcg aaaaagcggc agacggcata agcgaagcgt 629041 gcaatgttct cagcactccg gttatcggcg gtaacgtatc gctttataac gaatcaaacg 629101 gcacggcgat ctatccgaca ccagttatcg gcatggtcgg cctaattgaa gatacagcgc 629161 acattacaac acagcatttc aaacaagcag gagatctcgt atacgtgatc ggcgaaacaa 629221 aaccagagtt tgccggaagc gagctgcaaa aaatgacaga aggccgtatt tacggcaaag 629281 cgccgcaaat cgatcttgat gtagagctgt ctcgtcaaaa agcactgctt gacgcgatta 629341 aaaaaggctt cgttcaatct gcgcatgatg tgtctgaagg cggcttaggc gtagcgattg 629401 cggaaagtgt catgacgacg gaaaaccttg gcgctaatgt gactgtagaa ggggaagcgg 629461 cgttattatt ctctgaatct caatctcgct tcgtcgtttc agtgaaaaaa gaacatcaag 629521 ctgcgtttga agcaactgtc aaagatgcag ttcatattgg tgaggtaaca gctgacggaa 629581 ttctggcgat tcaaaaccaa gacggacaac aaatgattca tgcgcaaacg aaagagcttg 629641 aacgcgtatg gaaaggagct atcccatgct tgctgaaatc aaaggcttaa atgaagaatg 629701 cggcgttttt gggatttggg gacatgaaga agccccgcaa atcacgtatt acggtctcca 629761 cagccttcag caccgaggac aggagggtgc tggcatcgta gcgactgacg gtgaaaagct 629821 gacggctcac aaaggccaag gtctgatcac tgaagtattt caaaacggcg aactcagcaa 629881 agtaaaggga aaaggcgcta tcgggcacgt tcggtacgca acggctggag gcggcggata 629941 cgaaaatgtt cagccgctcc tcttccgttc ccaaaacaac ggcagcctgg cgcttgctca 630001 taacggaaat cttgtcaacg ccactcagct gaagcagcag ctcgaaaatc aagggagcat 630061 ctttcaaacc tcttcggata cagaggtttt ggctcacctg atcaaaagaa gcggacactt 630121 cacgctgaag gatcaaatta aaaactcgct ttctatgctg aaaggcgcct acgcgttcct 630181 gatcatgacc gaaacagaaa tgattgtcgc acttgatcca aacgggctga gaccgctatc 630241 catcggcatg atgggcgacg cttatgtggt cgcatcagaa acatgcgcat ttgacgtcgt 630301 cggcgcaacg taccttcgcg aggtagagcc gggagaaatg ctgatcatta atgatgaagg 630361 catgaaatca gagcgttttt ccatgaatat caatcgttcc atttgcagca tggagtacat 630421 ttatttctcc agaccagaca gcaatattga cggtattaat gtgcacagtg cccgtaaaaa 630481 ccttgggaaa atgctggctc aggaatccgc agttgaagct gacgtcgtaa ccggggttcc 630541 ggattccagt atttcagcgg cgatcggcta tgcagaggca acaggcattc cgtatgagct 630601 tggcttaatc aaaaaccgtt atgttggcag aacgtttatt cagccgtccc aggctctgcg 630661 tgagcaaggc gtcagaatga agctgtctgc ggtgcgcggg gttgtagaag gcaaacgcgt 630721 cgtgatggtg gatgactcta tcgtgcgagg aacaactagc cgccggattg tcacgatgct 630781 aagagaagcg ggtgcgacag aggtgcatgt gaaaatcagt tcaccgccga tcgctcatcc 630841 gtgcttttac ggcattgaca cttccacaca tgaagaactg atcgcgtctt cgcattctgt 630901 tgaagaaatc cgtcaggaaa tcggagccga taccctctca tttttgagtg tggaagggct 630961 gctgaaaggc atcggcagaa aatacgatga ctcgaattgc ggacagtgtc tcgcttgctt 631021 tacaggaaaa tatccgactg aaatttacca ggatacagtg cttcctcacg taaaagaagc 631081 agtattaacc aaataaaact tgaaaaatga cataaaggca gcgcagttcg gctgcctttc 631141 tctttctgcc ctcgttcggg gagatatttt gaaaagcgcc ttaaaggagt gaataggatg 631201 tctgaagcat ataaaaacgc aggagttgac atcgaagccg gatatgaagc tgtaaaacga 631261 atgaaaaaac acgtggagcg cacgaaacgg cttggcgtta tgggcagcct tggcggtttt 631321 ggcggcatgt ttgacctgtc tgagctttct tatcaaaaac cagttctcat ttcgggaacg 631381 gacggtgtcg gcacaaaatt aaagctcgct ttttccatgg ataagcatga cacgattggc 631441 gtggatgctg ttgcaatgtg tgtcaatgac gtgctggcac aaggtgcaga gccgctgttt 631501 ttcctcgatt atttagcggt tggcaaagcg gacccagtga aaattgaaca gattgtacaa 631561 ggtgttgcgg aaggctgtga gcagtcaggt tcagccttag tcggcggtga aacggctgaa 631621 atgccggggc tctatacagc tgatgaatac gatattgccg gtttctcagt cggagtggca 631681 gaaaaggacg aaatcgtgac tggagaaaaa attgaagagg gccatctgtt gatcggcctc 631741 agctccagcg gccttcacag caacggcttt tcccttgtca gaaaagtgct tctggatgat 631801 gcggagctgg acctcgatac aacatatgag ccgtttgaac gcccgcttgg cgaggaattg 631861 cttgaaccga caaggattta cgtgaagcct gtgcttgccg cggtcaaaag cggaaaaatc 631921 gacggcatgg cgcacgtgac aggcggagga tttattgaaa atattccgcg tatgcttccg 631981 gaaggcttaa gtgcggaaat tgatcatggc tcatggccga tcccgccgat tttttctttc 632041 ttgcaagagt acggcaagct aaaggaagaa gacatgttca acgtctttaa tatgggtatc 632101 ggttttgttt tggcagtcaa agaagagcat ctgacagatg tgatcggaac gcttgaaagc 632161 catggcgaaa aagcctattt aatcgggcgt gtgaaaaaag gtgaaggcgt cacattcggc 632221 ggtgcggcac tttcatgaaa aagtttgcgg tatttgcatc aggaaacggt tcaaacttcg 632281 aagccatcgt cacgcgtttg aaggaggaga actgggatgc gtcagcagcg ctcctcgttt 632341 gcgacaaacc gcaggcgaaa gtcatcgaac gggcggaagc attccacatt ccatccttcg 632401 catttgagcc gaagtcttat gaaaacaagg ctgcatttga acaagccatc attgaacagc 632461 ttcgtcttca cgaggttgaa ttgattgctc ttgccggcta tatgaggctg atcggtgata 632521 cgctccttca agcatatggg ggaaaaatca ttaacattca cccatcgctt cttccggcgt 632581 ttcctggaat cgacgcagtc ggacaggcgt tccgggcggg tgtgaaggtg gccggaatca 632641 ccgtgcatta tgtcgatgaa ggaatggata caggtccgat catcgctcaa aaggcaatcg 632701 aaattgatga acatgataca ttggaaacaa tcgaacagcg aattcacaag cttgagcata 632761 aatggtatcc gagtgtgatt aaacagctat taggattaaa taacagaggt gaaaaggcat 632821 gaccattaaa cgtgcattaa tcagtgtttc agataaaaca aatctcgttc ctttcgtaaa 632881 agaactgaca gagcttggcg ttgaagtcat ctccacaggc ggaacgaaaa agcttcttca 632941 agaaaacggt gtggatgtga tcggaatttc tgaagtgaca ggctttcctg aaattatgga 633001 cggccggtta aaaaccctac acccgaatat tcacggcggc cttctggcgg ttcgcggcaa 633061 tgaagagcat atggcgcaga tcaatgaaca cgggattcag ccgattgacc tcgttgtcgt 633121 caacctctat ccatttaaag aaacgatttc taaagaagac gtcacgtatg aagaagcgat 633181 cgaaaatatc gacatcggcg gacctggcat gctgcgcgcg gcatcaaaga accatcagga 633241 tgtcacggtt atcgtcgatc cggccgatta cagcccagtg ctaaatcaaa tcaaagaaga 633301 aggcagcgta tctcttcaga aaaaacgcga gctcgcggca aaagtattcc gtcatactgc 633361 ggcatatgat gcactgatcg ctgactatct gacaaatgtt gtcggtgaaa aagaaccaga 633421 gcaattcact gtgacatttg agaaaaaaca atcgcttcgc tatggagaaa acccgcatca 633481 ggaagcaact ttctatcaaa cagctcttcc tgtcaaaggc tccattgcgc aagcagaaca 633541 gcttcacgga aaagagcttt cttacaacaa cattaaagac gcggatgctg cagttcaaat 633601 cgttcgtgaa ttcactgaac cggctgctgt tgctgtgaag catatgaacc cgtgcggcgt 633661 gggaacagga aaaacgatcg cagaagcgtt tgacagagcg tttgaagcgg ataaaacatc 633721 tatcttcggc ggcattatcg cgctgaaccg tgaagtggac aaggcaactg ccgaagcgct 633781 tcacaacatt ttcttagaaa tcatcattgc gccttcattc agccaagaag cgctcgacgt 633841 cctgactgcg aagaaaaatc tccgtctgct gacgcttgac gtatccgccg ctgttcaaaa 633901 ggaaaaacag ctgacatccg ttcaaggcgg gctgctgatt caagatttag atatgcacgg 633961 cttcgatgat gctgagatta gcattccgac aaaaagagag ccgaacgagc aagagtggga 634021 agacttgaag cttgcttgga aagtcgtgaa gcatgtgaaa tcaaatgcga ttgttctcgc 634081 gaaggacaac atgacagtcg gcgtgggagc aggccaaatg aaccgcgtcg gatcggcaaa 634141 aatcgcaatc gagcaagcag gggaaaaagc gaagggcagc gcgctcggtt cggatgcata 634201 tttcccaatg ccagatactg tcgaagaagc ggcaaaagcg ggcgttacag ccatcattca 634261 gccaggcgga tcgatccgag atgaggattc catcaaaaaa gcggatgaat acggcattgc 634321 catggtattc accggcatca gacacttcaa acattaaggg gatgaaaacg acgtgaatgt 634381 attaattatc ggtaaaggcg gaagagaaca tacgctggcg tggaaggcag cgcaaagcag 634441 cctcgtcgag aatgtatttg ccgctcccgg aaatgacggc atggcagctt ccgctcagct 634501 tgtaaacatt gaggaaagcg accacgcagg gcttgtctca tttgcaaaac aaaatcaggt 634561 cggcctgacc attgtcggcc ctgaggttcc tttaattgaa ggtctggtgg atgaattcga 634621 aaaagcgggc ttacatgtgt tcggtccgtc aaaagctgcg gcgatcatcg aaggaagcaa 634681 acagttcgct aaggatttaa tgaagaaata cgacattccg accgcagaat acgagacgtt 634741 tacatccttt gatgaggcga aggcatatgt gcaggaaaaa ggtgctccga ttgtgataaa 634801 agcagatgga cttgcagctg gaaaaggcgt tactgtggct atgacagagg aagaagcaat 634861 tgcgtgcttg catgactttc ttgaagatga aaagttcggt gatgcgagcg cgtccgttgt 634921 cattgaagaa tatctttctg gtgaagaatt ttctctaatg gcctttgtca aaggggaaaa 634981 ggtgtatccg atggtgattg cccaggatca caagcgggcg tttgacggag acaaaggccc 635041 gaatacaggc ggcatgggcg cctactcgcc agttccgcaa atttcggaag aaacggtccg 635101 ccatgctgta gaaacgatcg ttaagccggc tgcaaaagca atggtacaag aaggccgttc 635161 cttcactggc gttttgtacg ctggattgat gcttactgaa aacggctcga aggtcattga 635221 atttaatgcc cgtttcggcg atccggaaac acaggtcgtg cttccgcgca tggaatctga 635281 tctggtacag gtgcttcttg atcttttaga tgataaggaa gttgacttaa gatggaagga 635341 taccgcggca gtgagtgttg tgcttgcatc agaagggtat ccggaaagct atgcaaaagg 635401 cacgccgatc ggcagccttg cagcagaaac tgagcaggtc gtggtcttcc atgccggaac 635461 gaaagcagaa ggtggagagt tcgttacaaa cggggggcgc gtcgccaatg tgacggcttt 635521 tgatgaaacg tttgaagcgg ctagagaccg agtgtacaaa gcggttgatg aaattttcaa 635581 accgggactc tttttcagaa aagacattgg ggcacgcgct ttaaaggctg cccaaaaata 635641 agtgaggaaa acccgcagaa tagctgcggg ttttttgtta tcaaaaagcg ggatggcagc 635701 tagaagaaga aagcacaacg agcgtggttg gttttccatg ggccatcgag gtgtcaataa 635761 aatcctcaag cgtatgtacc gattcagtca cgacctttgt cacatagctg tacatccccg 635821 tgatgcggtg gttttctgct acatcaggat gcgatgttgc aaaggcggcg tagtgcttgc 635881 agcttttcgg ctccatgaga ataaaagcgg tgacatgctt gtttagtttt tcgtaacaga 635941 tattcgcgct gtagccggta atcactcctt tgtcttccag cttcctgaca cgctccgccg 636001 cgcttggcga gctgagtccg acaagctttc ccagctcaac catcgttaat ctgccgtttc 636061 gctgcaaatg cgagagaatc tgaaggtctg tatcgtccat ttgtctggct cctttacata 636121 tttaggcgaa tgaatgaaaa ttcctttgat cgtaaggtaa tgctgttgat ttaacttcat 636181 tgtagcatat ggatgccgtc ttattttttc tataataaag ccatcaatca gagagggggc 636241 atcatgttgc cagaattgca gcgctctatt acttggatac aagggacggc gttaacgatt 636301 ggggcggttt taggatgcgg gatattaatc ctgccgtctg tcaccgcgga cacggccggc 636361 cccgcttctt tatttgtttg ggtgttcatg tccttcttat ccttttttct tgtcggcacg 636421 ctggcccggc ttgtgaaaat agcgcctagc gcgggaggaa tcacggctta tgtgcagctg 636481 gcctttcaga aaaaagccgg ggctattttg ggctggatca tgttagggtc cgttccgatc 636541 ggcgttccca tcatcgcttt gactggcgcg cattacgtca gttacatcac agaggcggcc 636601 gattggcaga ttacattgat tgctggttgc atgctggcta tatctatttt gcttcatatg 636661 agagggattc aactatcagc aaacattagt acactcgtta tatgtgtcat cgtatttctg 636721 cttgtcactt ctattgctgt gtcattgcca cacgtcacga tagcagaatt caagccgttt 636781 cttccgcatg gctggtctgc cgctggatct gtttctgtta tgattttttt ctcttttgta 636841 ggctgggaaa tgattacccc gttggctgag gaatttcatc gtcctgaaaa agatgtcccg 636901 ctcagcttgt ttttggcagc gtcttgtgtg gcggggctgt atatcatgct gtcatttgtg 636961 accgtgggta ctcattcata tggagagaat ggagaaattg catcgcttgc catgctcatt 637021 tcaaaaggag caggagaaag cggtgtatat gtcacggtat gtttagcgct gtttattaca 637081 ttcgccacca tccatgccaa tattgccggt ttttcaagaa tggtgtacgc attggcgaga 637141 gaggggcaca tacccgtatt ttttggaaaa ctcagtgcga caaaacgtac gcctattcgc 637201 gttttgacag cgatggccgc agtgtttggc ttagtgcttg cagcgcatgg tctgtttcaa 637261 atcgatttga cgactctgtt gaaagggccg agcgcggctt ttatcgcatc ttacatatgt 637321 acaatggcgg cagcactgaa actgctgggc aggagagata taggctggtg gatggcgctc 637381 ggggcatttg tggcgtgcgc ggtgatttat tcattcagcg gctgggcact gctttatccg 637441 gcagtgctgg cagctgcagg atatttctat atgaaaacaa agggtgggca taaaaaaaag 637501 cttgatcacg ttttgtgatc aagcttttcc atttatccgt tttgatgctc gttatttcca 637561 gaatcgctgt gttgaaacat gtaggtcaca ggacagaagc gcaagattcc cgaacccgct 637621 ttcatggccc ccataaagat gtaaaagaga tgcattctgc accaaggttt tttcgtaaac 637681 tttgcactgg cggctgacat aatcgtcaat ccgcaggcga ttctgaacac ggcattgatg 637741 agactgatgt ttggcttcaa ggaaatccgc tccttttact taaaaaagtt ttttaatcga 637801 accttcaaaa atttgtaacg tttttatcgt gcgtgatgag gaaggatgtg ataccatgag 637861 tctaatacat gtaaaggaga gtatgtgaat gtccgaacgc acctttaact ggaaaaacaa 637921 agacatcagg gcacaggttg atgttgtaga ctcaaagctg cttccaacgc tccttttacg 637981 gaatgctctc gtcttaaatc catatgtaaa acaatggctg aaaaaaaaca tttggattta 638041 tcaggaccgc attgtttatg tgggtcatga acttccgaat agagccgaag aaattcatac 638101 gattgattgt gaaggaaaat acattgtgcc aggttatatt gaaccgcacg cacatccttt 638161 tcaaatatat aatccccaaa cactggcgga atatgtgtct caatacggaa caacgacatt 638221 cgtgaatgat aacttatttt tgcttttgca aagcggaaaa aagaaagcgc ttacgatttt 638281 gaatgaactc aaaaagcagc ctgtccagta tttttggtgg tcacgctatg acctccagac 638341 cgaggttctg aacgaggacc acgtccttcc atttgacgtc agaaaacagt ggattgaaca 638401 tccggatgtg attcaaggcg gagaaatgac cggatggcct cgcctggtag atggtgatga 638461 tttaatgctc cactgtatgc aagctacaaa gaaacagaga aaacgtattg aagggcattt 638521 tcccggcgct tctgataaaa cgcttacaaa aatgaagctg ttcggtgcgg attgtgatca 638581 tgaagcgatg acaggtgatg aagtgatgag aaggctggaa ctgggctatt atgtttccct 638641 tcggaactct tccattcgcc ccgatgtaag aaaaatcttg caagagctgc atgagaaggg 638701 cttccgctat tatgaccact tcttttacac gacagatggc gcaaccccga atttctataa 638761 aggcggcatg acaaacgagc tgattcgcat tgcgttagaa gaaggcgtac ctgcaatcga 638821 cgcctacaat atggcatcat ttaatatcgc aaagtattac caaatggatg attatttagg 638881 agttgtcgga ccgggcagac tggcatcgct aaacatactg gaagatccgt taaatccgaa 638941 tccagtgact gttctgtcaa aagggaccat tctgcgtgaa aacggctgtg atttgaaggc 639001 gtttacaaag acggactggc acaaaggcgg tcttgtcccg cttgagcttt catatgatat 639061 gacgatggat gacttgcagt tttctatgcc gatgggcgtg aaaatgcgga atgcggttat 639121 tatggagcca tatatgattg agatcgacaa ttcgatggaa cagctctcgt ttgaccatga 639181 tgaaagttat ttgacgatgc tcgacagaca cgggaaatgg cgcgtcaata cgatgataaa 639241 agggtttgcc tcaagcgtgc agggatttgt aagctccttt acgacgacgg gcgacattgt 639301 cgcgattgga aaaaataaag cggatatgct gctcgctttc gcccgcatga aagaaatcgg 639361 aggaggaatt gttttagcgg agaacggaaa cattctgcat gaaatcccgc ttgcgctgtg 639421 cggctgcgcc tcttcggaag cgtatgaaga cgtgcttgag aaggaacaaa agctgagaga 639481 tcttttgact gaaagaggct atgagttttg cgatcctatc tatacgctgc tctttttgca 639541 aagtacgcac cttccgtata tacgcattac gccaagagga atattcgacg tcatgaaaaa 639601 aactgtactc tttccatcga taatgcgtta aaatataaaa gagcagggag ccgacatatg 639661 aaaaaatgga tgacagtttg cgcgctgtgt ttcgtgtttt ttctgctggt atcctgccag 639721 cagaaggatg ctgtcccgga tactgcaaag aagctgaaag ctcctttaac ggggctaaag 639781 actgaacaga aagtgactga acgccgccct gttgctgttg tggtgaacaa tcacccgaag 639841 gcgaggccgc agtcgggtct gtctaaagcc gacattgtca tagaagcgct agccgaaggg 639901 caaatcacaa gatttctggc cattttccaa agccagatgc ctgaaactgt cggacctgtg 639961 cggagcgcgc gggaatattt cgtcactctc agcaatggct ttgacagcat atttgtccat 640021 cacggctgga gtcccggcgc caaaaagcag ctggaatccg gagctgccga ttatatgaac 640081 ggattggatt ttgacggaag cttattttgg agagctgatt tcagcaaacc gccccacaat 640141 tcctatacgt cttatgatta cataaaaaag gcggcagaac aaaagggtta taagctgaag 640201 caggaaacaa atccgctgct gtttcaaaca tcagatgcaa aacctgcaaa tgaatcttac 640261 aatgttcggg tagattatgg aacaaataac gttacaaatc ttgtcgaata caactatgat 640321 aaaaaagctg aattttatac aagaagctct gatggtgtca taacgacaga ccgggaaacc 640381 ggaaagccgg ttgcaatgca aaatattttc attgttgaag ccagccatca tattattgat 640441 caagatggaa ggcgggacat cgacttggaa tcaggaggaa aaggtctgtt gtttcagcac 640501 ggaaacgtca ttgaaacaga ctggaaacaa gtgaatggca gaattgtgcc ggtaaaagac 640561 ggcaagtggc ttccgtttgt gccaggaaag acttggatca atatcgtacc tgatcttgat 640621 gcggcttcca ttagtaaagg agaaggtgtg taacgatgca aatcgataaa ttacgcggca 640681 aagagctgga ccagttattt aactcgatct tatcgctgaa agacctggag gaatgttacc 640741 gattcttcga tgatctatgc acaattaacg aaattcaatc gctggctcag cgccttgaag 640801 tggcgcgcat gcttcgcgaa ggaaacacgt atcataagat tgaaacagaa acaggcgctt 640861 ccacggctac gatttcccgt gtgaaacgct gcttaaatta cggaaatgac gcttatgaaa 640921 tggcgcttga ccgtgtgaag gagacggaaa cagagtcttc ttccaaataa aaaaccgccc 640981 tgccgtctgg caagggcggt ttctttatga aacaaattga tggatcaggt tgtcgatatt 641041 gatgatactg ccatcctctt tccgatagac aacatgctcc ttggaaaaat gaatcggcga 641101 attaatccct gctgcggctg caaggttaaa tagtccctcg cgcaatgaaa taacgtagtt 641161 gcagacacga tgctgttttt cctcaacgct cagtgctttt tgcaatttcg gatctgtcgt 641221 cgccacacct gccggacagg tgttggtgtg gcagacgaga gcgcggatgc agccaacgga 641281 aaacatcatg ccgcgtgcga tgttaacaaa gtcagcgccg agggctaagg cgaccgcgat 641341 tttatcagga gtcaggagct ttccggaagc aaagattttc agctggctgc gcaagccgta 641401 ctgtttaaga agcgtgtcca caataggcag cgctgtcata atcggaaggc cgactgtatc 641461 cgcgagctcg taaaaggaag ctccggtacc gccttcactt ccgtcgatcg tgataaaatc 641521 cggatgcttt ccgcttttct gcatatgaga gaaaagctca tgcaattctt caggatgccc 641581 tgcgaccagt ttgatgccga ctggcttttg tccgacatct ctaagttttt caataaagtc 641641 gagcatttca ggagggtttg agaattcata aaagcggttc gggctgtcaa tcgactttcc 641701 aggttcgaca ttccgaatgt ctgccacttc ctctgatact ttggcgccgt ccacatggcc 641761 gccgcgggtt ttcgctcctt gtgccagctt tagctcaaac gctttaatct ggtcaatcct 641821 gctttttctt ttaaattcct cccacgaaaa ttccccgttt cttttgcgca cgccgaatag 641881 gcccggtccg atttggcaaa tgatatcggc gccgcccttt aagtgatatt cagacaatcc 641941 cccttcacct gtattcatcc aggtgccgcc tgccagatgg agcccttttg agagcgccgt 642001 aacagcccgt tctccaagag aaccgtagct catggcagac tggccgacta agcccttcac 642061 ataaaatggc ttctcgcatg tatgctcgcc aatcacctgt acatcatcag gatggagaaa 642121 atacgggtct gccttgatat gttcggcatg ctccttgcgt ttgaacagat tgtcagcatc 642181 cattttatag atttgggttt caatttttgg cgtttgattt acatgcattt cttccctttg 642241 ttttggaaac atagcgttac ggatataata gccaggttta tcaaaatctc ttacagatcc 642301 aaagcccatc attctgcttt tgtatttgcc ggagatgacg gtttgctcat attcctttcg 642361 tgaaaatggc tgctcttcat tgtcattgct gtataaatac tgtctgagct ccggcccgat 642421 tttttcaagg atataccgaa accttccgat gacgggatag ttgcgaagaa ttgagtgctc 642481 ctgctgtttt tcatccttta tgtagatcca ggcaaacaag acgatcggga tagcgatgat 642541 cccaatgata aatgcgatga gtgctattat gatggtttcc atctctcagc ctcccttttt 642601 atgtaaccat ttccacagta gaacactttc caaacaatag cagaaggaat ctggtgaaaa 642661 atgtgtgctc ctgccgatac aggactcacc atgcaggtac tgccatatgc tctctttttt 642721 tatgaaaaaa gaatcaaaac acctttttca gtgaataacg agattaacgg ctttttccgt 642781 ttttccgcgc tatgtgaatt tgttataatg tttaaatggt aacaaacgaa tggaggaacg 642841 tatgacgtgt acgatgtaac ggagtggaag catgtcttta aactcgatcc aaataaagat 642901 ttgcctgacg aacagctgga gattctttgc gaatcaggaa cggatgcggt cattatcgga 642961 ggaagcgatg gtgtgacaga ggataatgtc ctgcggatga tgtctaaggt aagacggttt 643021 ttggtgccgt gtgtcctaga ggtatcagcg attgaagcga ttgttcccgg ctttgactta 643081 tattttattc cgagtgtatt aaacagcaaa aacgcggatt ggattgtcgg aatgcaccag 643141 aaagccatga aggaatacgg agaactgatg tctatggaag aaatcgtggc ggagggctac 643201 tgcatcgcaa atccagattg caaagccgcg gcactgactg aagcggacgc cgatctgaat 643261 atggatgata ttgtcgccta tgcgcgtgtg tcggagctgc tgcaactgcc gattttttat 643321 ttagaataca gcggcgtgct tggagacata gaagctgtca agaaaacgaa ggctgtattg 643381 gaaacgtcca ccttgtttta cggcggcggc atcaaggatg cggaaacggc caagcagtac 643441 gcagagcatg cggacgtgat cgttgtaggc aatgcggtgt atgaagattt tgacagggct 643501 ttgaaaacag tagcggctgt gaaaggcgag tagtaaattg tacggatttg gtttatgata 643561 gaacgtatgt tttgtatagg cgggtgaaca aattttgaat tatattagca atcaattact 643621 aagcggttta aaccccgttc agcaggaagc agtcaaaaca acggacgggc ctcttttgct 643681 gatggcggga gcgggtagcg gaaagacgcg tgtcctgacc catagaattg cttatttaat 643741 ggcagaaaag catgtggcgc cgtggaacat tctggcgatc acatttacaa ataaagcggc 643801 acgcgaaatg aaagaacgtg tggaaagcat cctcggaccc ggcgcggacg atatctggat 643861 ctccacattc cacagcatgt gcgtgcggat cttgcgcaga gatatcgacc ggattgggat 643921 caaccgaaat ttctccatcc ttgatacggc tgaccagctt tcagtgatca aggggatttt 643981 gaaggagcgc aatcttgatc cgaagaagtt tgacccgaga agcatcctcg gcacgatcag 644041 cagtgcaaaa aacgaattga ccgaaccgga ggaattctct aaagttgctg gcggctacta 644101 cgatcaggtg gtcagcgatg tatatgctga ttatcagaag aagctattga aaaaccagtc 644161 gctcgatttc gacgatttaa ttatgacgac gattaaactg tttgacagag tgcctgaagt 644221 gcttgaattt tatcagcgca aattccagta catccacgtt gatgagtatc aggatacgaa 644281 cagggcacaa tacatgctcg ttaagcagct tgccgagcgt ttccagaacc tttgcgttgt 644341 gggggattct gatcagtcaa tctacagatg gcgcggcgcg gatatcacca acattctttc 644401 atttgaaaaa gattatccga atgcaagcgt gattttgcta gaacaaaact atcgttcaac 644461 gaaacggatt ttgcgcgcgg ctaacgaggt cattaaaaac aactctaacc gcaaaccgaa 644521 aaatttgtgg acggaaaatg atgaaggcat caagatttcc tattatcgcg gtgataatga 644581 gttcggtgaa ggacagtttg tggccggcaa aattcatcag cttcacagca caggcaagcg 644641 gaagctgtcg gatatcgcca tattataccg gacaaacgcg cagtcccgtg tgattgagga 644701 aacgcttctc aaagcgggct tgaactataa cattgtcggc ggcacaaagt tctatgacag 644761 aaaagaaatt aaagacattc ttgcgtacct gcgcctcgta tccaatccgg atgacgatat 644821 cagtttcacg cgcattgtca atgtgccgaa gcgcggagtc ggcgcgacat cacttgaaaa 644881 aatcgcttcg tatgcggcca taaacggctt gtcctttttc caagcgattc agcaggttga 644941 ttttatcggc gtcagtgcca aagcggcaaa cgcgcttgac agctttagac agatgattga 645001 aaacctgacc aatatgcagg attacttatc cattacagag ctgacagaag aaattcttga 645061 taagacggaa tacagagaaa tgctgaaggc tgagaaatcg atcgaagccc aaagccgttt 645121 agaaaatatc gacgagttcc tgtctgttac gaaaaacttt gaacagaaaa gtgaagacaa 645181 gacactcgtt gcgttcctga cagacttggc attgatcgca gatattgatc agctcgatca 645241 gaaggaggaa gagtcaggcg gcaaggatgc gatcaccctg atgacactgc acgccgcgaa 645301 aggactggag tttccggttg ttttcttgat ggggcttgaa gaaggcgtct tcccgcatag 645361 ccgttcactc atggaggaag cggaaatgga agaagaacgc cgccttgcgt acgttgggat 645421 tacaagggcg gaacaggagc tttatctgac caatgctaaa atgcgcacct tgtttggccg 645481 gacaaatatg aacccggaat ctcgcttcat tgctgaaata ccggatgatt tattggaaaa 645541 cctaaatgag aaaaaagaaa caagagcgac gtctgcgaga aaaatgcagc cgagacgcgg 645601 ccctgtttca cgcccggtat cctacgccag caaaacaggc ggcgacacct tgaactgggc 645661 agtcggagat aaggcgggcc ataaaaaatg gggaacagga actgtcgtca gcgtgaaagg 645721 cgaaggagaa gggacagagc ttgatattgc cttcccgagc cctgtcggcg tgaaacgcct 645781 gttagcagca tttgctccta ttgaaaagca gtaattgaag aggaaaggaa gaagcagatg 645841 gacaaagaaa cagcgaagca gcgggcagaa gaactgcgcc gcaccatcaa caagtatagc 645901 tatgaatatt acaccttaga tgaaccgagc gtcccagatg ccgaatacga cagattgatg 645961 caggagctga tcgcgatcga ggaggagcac ccagacctca gaacgcctga ctctcctacg 646021 cagcgcgtcg gcggagccgt gcttgaagcg tttcagaaag tcacccacgg cacaccgatg 646081 ctcagtctgg gcaacgcctt taatgctgat gatcttcgtg atttcgaccg ccgtgtgcgc 646141 cagtccgtcg gcgacgatgt ggcgtataat gtggagctga aaatagacgg tcttgctgtt 646201 tctctccgtt atgaagacgg ctattttgtc agaggggcca caagaggtga cgggacgacg 646261 ggagaggata tcacggagaa tctgaagacg atccgcaata tcccccttaa aatgaaccgt 646321 gagctgtcga tcgaagtgcg cggcgaggcg tatatgccga agcgttcgtt tgaagcactc 646381 aatgaggaac ggattaaaaa tgaggaagaa ccgttcgcca atccgcgaaa tgccgcggcg 646441 ggatctctca gacagctcga tccgaaaatt gcagcgaaac gaaacctcga tatcttcgtc 646501 tacagtatag cggagcttga cgagatgggt gtagagacgc aaagccaagg gcttgatttt 646561 ctcgacgaac tcggatttaa aacgaatcag gaacgaaaaa aatgcggcag catagaagaa 646621 gtcattacgc tgatcgatga gcttcaggcg aagcgcgcgg acctgccgta cgaaatagac 646681 ggcattgtca ttaaagtcga ttctctcgat caacaggagg agctcggttt tacggcgaaa 646741 agcccgcgct gggccatcgc gtataagttt cctgctgaag aggtcgtgac gaagcttctc 646801 gatatcgaat taaatgtcgg cagaacgggt gtgattacgc cgactgcgat tcttgagccg 646861 gtaaaagttg ccggcacaac ggtctcaaga gcatcccttc ataacgaaga tttaattaaa 646921 gagaaggaca ttcggatttt ggataaggtt gtcgtcaaaa aagcgggcga tatcatcccg 646981 gaagttgtga atgtcctcgt tgaccagcgc acaggagaag aaaaggaatt cagcatgccg 647041 acggaatgtc ctgaatgcgg cagtgaactc gtccggatcg aaggagaagt ggcgcttcgc 647101 tgcattaacc ctgaatgtcc ggcgcaaatc cgggaagggc ttatccattt cgtttcccgg 647161 aatgccatga acattgatgg gctcggcgaa cgagtgatca cacagctgtt tgaggaaaac 647221 cttgtccgca atgtggcaga tttatataag ctgacgaagg aacgagtcat ccagctcgag 647281 cgcatgggcg aaaagtccac tgaaaacctg atcagctcca tccaaaaatc aaaagaaaat 647341 tcgttagagc gcctgctgtt tgggcttggc atccgtttta tcggatcaaa ggccgcaaag 647401 acgcttgcca tgcattttga aagcttggag aacctgaaaa aagcctctaa agaggaactt 647461 ctcgcggtag atgaaatcgg tgaaaaaatg gctgatgctg tgatcaccta ttttcataaa 647521 gaagaaatgc ttgaactctt gaatgaactt caggagctgg gcgtaaacac gctctacaaa 647581 ggcccgaaaa aagtaaaagc agaggacagc gactcttact ttgctggtaa aacaattgtt 647641 ctgacaggaa agctggaaga gctgtcaaga aacgaagcca aagcgcaaat cgaagcgctg 647701 ggcggaaagc tgactggaag cgtcagcaaa aacacagact tagtcatcgc cggagaagcg 647761 gcgggaagca agctgacaaa agcacaagag ctgaacattg aagtgtggaa tgaagaacag 647821 ttaatgggag agctaaagaa ataagaggag tgttttctat tgaaaaagac gttggcattg 647881 gcggcaacgg cggcagtatt aatgctgtct gcctgctcgt caggtttcgg gggggagaag 647941 gaggaagaga ttacgcaaaa gacggcgaaa tcgtcagaaa aagcgattgt cccgaaatat 648001 aatatctctg actcctatta caaaatggtg ctgccgttta aggcaggcaa agcgcgcggc 648061 ttaacaacgg aacagctgaa tacaaggctg gacattgacg aatttgaaac agggctgatg 648121 cgccttgccc aagattcttt ctcaactgac gattatctgt tccaagaagg acaatattta 648181 gatgaggata cagtattaag ctggctggca cggaaaaaaa cgggctctga tttgaaaaaa 648241 gccgaaaaag aagataagaa cttcaaaaat gaaggcttga acccggcgct cccgagttct 648301 ggttcaacag aagaaaagaa cgaaagcagc ccaatttatt tagcatccat gcttgagcac 648361 gattatttag tcagaaaaga caagaattct atccagcttg gcggcgtcat gatcggactg 648421 gcgttaaact cagtgtatta ctatcgtgaa aaaactggcg acccgcaaaa agaagtggag 648481 attaaagaca gcacgcttcg ccagcaggga gaaaaaattg cacaggaggt tattaaccgc 648541 ctccgcaaaa aagataactt gaagaatgtg ccgattaccg tggcgctcta caagcaggcg 648601 tcaaaaacat cgattgtgcc ggggaacttc atcgccaaaa cagaggtcaa agcaggctct 648661 actgatatct caaattggga tgacatcaat gaaaaatatg tattctatcc ggcggataca 648721 accacagcag aaaagtaccc ggatgacacc gaggtcttta agcggttcaa aaactcaatt 648781 gaagaatatt tcccgaacta tacaggcgtt gtcggtacag cgctgtatga aaatgatgaa 648841 atgaagaaaa tgaagattga cataccaatg caattctacg gaaaaagtga agttgtcgcg 648901 tttacccagt tcttaacggg tgaagtgatg gactactact ctaagagctc agttgatgtc 648961 gaagtcaata tcacgtcctc agacggacag gaagcggtca ttatccgcaa tgccggagat 649021 aaagagccga ctgttcacat ttatgactga tagaaaaccc ttgtgccata ttggcacaag 649081 ggtttttatg ttacaattaa caggaaaagg gaaaatattt tcacttctgc cgaaacacaa 649141 atcaagggga ggtatgttga tgctggaaat cgtgtgaaaa caatcattat caaatctata 649201 gcaatgaaag gatgttagac gtgcataaag atatcaaaaa aatatttcat gaagagcagg 649261 ttttggcaga agctgcagcg agatacggtt tctcaaaaga tcaggtgcgt tttctggctg 649321 atgcggaaaa ctatgtatat gaatgtatga aagacaatca accttatatt ttaaagatta 649381 cccatacgat tcggagatct tctgattata tgatgggaga gatggaatgg ctccgtcacc 649441 ttgcaatagg gggaatttca gtagccaaac cgctcccgtc gctgaacgga aaagacgtag 649501 aagcagtgcc ggacggaaac ggcgggtcat ttttattgag agtgtatgag aaagcgccgg 649561 ggcaaaaagt ggatgaatcg gactggaatg aaacgctatt ttatgagctt ggcagataca 649621 caggcagcat gcacagcctg acaaaaagct acaaattgag caatcccgct ttcaaaagac 649681 aggaatggga tgaagaggag caattaaagc tgagaaaata tgtgcctgaa gatcagataa 649741 aggtgtttca gcaagccgat tctttgatga atgaactgcg gaggctcccg aaaagccagg 649801 acaactacgg cttggtgcat gcggatctgc accatggcaa ttttaactgg gatcatggca 649861 aaatcacggc atttgatttt gatgatatcg gctacaactg gtttgttaac gatattagca 649921 ttcttctcta caatgtcctg tggtatcctg ttgtgccata tgatgataaa gctgcgttta 649981 cagaagaatt tatgacgcat tttatgaaag ggtactggga ggaaaatgag cttgaccctg 650041 catggctgat gataatacct gatttcctcc gccttcgcca tatgctgatt tacggattgc 650101 tgcatcagat gtttgacctt aacacaatag gagaagagga aaaagaaatg ctggccggtt 650161 tcagaagaga tatagagaat ggcacgccga ttacagcatt tgatttttca gcactggtgt 650221 agatagaaaa agccaatggg attccagtcc cattggcttt tataatgtat cacacttcac 650281 gccgactacg ccttcaatgg ctttaatgtc atagtagaca tcggtcgtgt atctgttttt 650341 atggacgcgg accttcactt ccataattgg aaaatccttt tcgcctaggt cgtcgatccg 650401 aacggagtgt gctttgatat ctcttctttt catttctttt aaaatctctg tcattttgtc 650461 tttatcagaa agtgacattc tgatgcggat gtctttttcc tgcaggcggt cggggccgat 650521 ttttctgacc acccatggga gaaattccac actgatcagg atgaacagaa gactggcaaa 650581 cgcttcttta taaaaaccgg ctcccgtagc aagcccgagc cccgctgccc cccagatcat 650641 ggccgatgtc gtcaggccgg aaatgacatc attgcttttt cgcaggatga caccggcgcc 650701 gataaacccg acgccggaga tgatttgtgc cggcagacga agcggatcca tcatgatgcg 650761 gtagtattta gggaaatgat atgccgcatt aatactgacg atcgtcagca tgcatgagct 650821 gactgcgatg acaatacagg tttttaatcc gagcggctta ttttttaatt cgcgttcaag 650881 cccgatgacc atgccaatca atgtggcaat gcccaatttc aataaaatat caggatcaat 650941 ataccagctc aacagcaaac ttcccccttc tctatggtgt ttttaaataa atatgatttt 651001 ctcacagtat ttatagcaaa acaagagcac aaaagccacc aagctgcgct tgatggctta 651061 ttgcttactt tttgcgtttt aacagctttt ccatgacacc gaataatcgg taagaggctt 651121 ttgcaggacg ttttgtgatc atgctgacaa tgatgccggc aatcatactg agaataaacc 651181 cagggatgat ttcgtacaca ccggttgatt ttgccaggcc ggttgtaatc cagatcaaca 651241 cggtcgcagc cccgacaatc atggcagcaa gcgcgcccca ttcgttcatt cgtttccaat 651301 acagactgag cagaatcgca ggcccgaaag ctgaaccgaa gccggcccaa gcgtatccga 651361 ccaaatcaag aatggtgctg ttcgggttca atgacaagag taccgcgata acggcaatga 651421 ctaagacgga caatcgcccg atcatgacca attctttatc agaagctttt cgtctgaaaa 651481 atgaccggta taaatcctct gttacagcac ttgctgtgac caagagctgt gaggaaatcg 651541 aactcatgat ggcagccaaa atagctgaca ataagaaccc tgtaattaat gggtggaaca 651601 agattttaga gaagataatg aaaatcatct ccggatcttt tacagcaact ccgaatttat 651661 gggcgtatgc aacaccgatt aaacccgtca gcacggaacc tagaactgta atgatcatcc 651721 agctcatgcc gattcggcgt gcaggtttta aatctttaat gtctttaatg gccataaatc 651781 ggacgatgat atgaggctgg ccgtagtagc ccaaccccca ggctaaatag gaaataatgc 651841 taatgacgct cgcgccttta aaaatatcca ataaatgtgg attaacagcg tcgatttcat 651901 ggaaagtcgg agcaacgccg cccacatggg taaaagcaac gatcggcaca agcactagtg 651961 ctgcaaacat gatcgcaccc tgcacgaagt cagtcagact gacagcaagg aaaccgccaa 652021 acagtgtgta taacacgaca actgcggtgg tcagaaacag gcctaatttg taatccgcac 652081 caaaagcaga ttcaaacagc cgtccgccag ataccatacc ggaagaggta tacaatgtga 652141 aaaagatcat gatgatcaat gcagatacga ttttcagcag tgatgaagaa tgctggaatc 652201 gtttatcaaa gaaatcagga attgtaatcg catcatctgc cgcttctgta taagcacgca 652261 gccttggagc cagcagcaag taatttgagt acgccccgat tgtaagacct aaagcaagcc 652321 ataaggtgga cagccctgtc gcaaacatcg cgccgggaac acccatcagc atccatccgc 652381 tcatatcggc cgcgccggca gacaaagcag taacgaatgg tccgaggcct cttcctccaa 652441 gcatgtaatc attgatgtca gtggttttct tgaatgcata ccagccgatt aacagcatgg 652501 caataaagta aattcctaaa gatataataa tttcaatact cacgttttac cctctcttca 652561 tttctaataa tgttgcatca cctctcaaat tgatggtgcc agttaagcag cctggcgtaa 652621 gtgcaaaaca aaagaaattc ttttgcgggt gcacttggta acttaaccta acaaagtatt 652681 cccggccatt caagcgatga aacattgatc ataagctgga aataccgttg caaacctaga 652741 agggaataaa gaataaaacg ctttcaaaaa ataattaaag taaaaatatt cagaaaaata 652801 tttcgtttct ccttctcctc attttagtat aaaatatata gggtattgtt tcgaaaacac 652861 aggcctgtct caaggcgttt tgttgcttta aagggcttgt ttttgatatg atcagtatta 652921 tatgacttaa cggagaaata tgtggaggtg gatcatatgt cacgaatttc aatagaagaa 652981 gtaaagcacg ttgcgcacct tgcaagactt gcgattactg aagaagaagc aaaaatgttc 653041 actgaacagc tcgacagtat catttcattt gccgaggagc ttaatgaggt taacacagac 653101 aatgtggagc ctacaactca cgtgctgaaa atgaaaaatg tcatgagaga agatgaagcg 653161 ggtaaaggtc ttccggttga ggatgtcatg aaaaatgcgc ctgaccataa agacggctat 653221 attcgtgtgc catcaattct ggactaaagg agggacacaa gaatgtcatt atttgatcat 653281 aaaatcacag aattaaaaca gctcatacat aaaaaagaga ttaagatttc tgatctggtt 653341 gatgaatctt ataaacgcat ccaagcggtt gatgataagg tacaagcctt tttggcatta 653401 gatgaagaaa gagcgcgcgc atacgcgaag gagcttgatg aggcggttga cggccgttct 653461 gagcacggtc ttcttttcgg tatgccgatc ggcgtaaaag ataatatcgt aacaaaaggg 653521 ctgcgcacaa catgctccag caaaattctc gaaaactttg atccgattta cgatgctact 653581 gtcgttcagc gccttcaaga cgctgaagcg gtcacaatcg gaaaactgaa catggacgaa 653641 ttcgccatgg ggtcatctac agaaaactca gcttacaagc tgacgaaaaa cccttggaac 653701 ctggatacag ttcccggcgg ttcaagcggc ggatctgcag ctgcggttgc tgcgggagaa 653761 gttccgtttt ctcttggatc tgacacaggc ggctccatcc gtcagccggc atctttctgc 653821 ggcgttgtcg gattaaaacc tacatacgga cgtgtatctc gttacggcct ggtcgcattt 653881 gcgtcttcat tggaccaaat cggaccgatt acacgtacgg ttgaggataa cgcgttttta 653941 cttcaagcga tttccggcgt agacaaaatg gactctacga gtgcaaatgt ggacgtgcct 654001 gattttcttt cttcattaac tggcgacatc aaaggactga aaatcgccgt tccgaaagaa 654061 taccttggtg aaggtgtcgg caaagaagcg agagaatctg tcttggcagc gctgaaagtc 654121 cttgaaggtc tcggcgctac atgggaagaa gtgtctcttc cgcacagtaa atacgcgctt 654181 gcgacatatt acctgctgtc atcttctgaa gcgtcagcga accttgcacg ctttgacggc 654241 atccgctacg gctaccgcac agacaacgcg gataacctga tcgaccttta caagcaaacg 654301 cgcgctgaag gtttcggaaa tgaagtcaaa cgccgcatca tgctcggaac gtttgcttta 654361 agctcaggct actacgatgc gtactacaaa aaagcgcaaa aagtgcgtac gttgattaag 654421 aaggatttcg aggacgtatt tgaaaaatat gatgttattg ttggaccgac tacaccgaca 654481 cctgcgttta aaatcggtga aaacacgaag gatccgctca caatgtacgc aaacgatatc 654541 ttaacgattc cggtcaacct tgccggcgta ccgggaatca gtgtgccatg cggattagca 654601 gacggacttc cgctcggcct gcaaatcatc ggaaaacact ttgatgaaag cactgtatac 654661 cgcgttgctc atgcatttga acaagcaaca gaccatcata aagcaaaacc tgaactgtaa 654721 ggggtgaaaa gaattgaact ttgaaacggt aatcggactt gaagtccacg ttgagttaaa 654781 aacaaaatca aaaattttct caagctctcc aacgccattc ggcgcggagg cgaatacgca 654841 gacaagcgtt attgacctcg gatatccggg cgtcctgcct gttctgaaca aagaagccgt 654901 tgaattcgca atgaaagccg ctatggcgct caactgtgag atcgcaacgg atacgaagtt 654961 tgaccgcaaa aactatttct atcctgacaa cccgaaagcg tatcagattt ctcaatttga 655021 taagccaatc ggcgaaaacg gctggatcga aattgaagtc ggcggcaaaa caaaacgcat 655081 cggcatcacg cgccttcatc ttgaagagga tgccggaaaa ctgacgcata cgggcgacgg 655141 ctattctctt gttgacttca accgtcaagg aacgccgctt gttgagatcg tatcagagcc 655201 ggacatccgc acgccggaag aagcgtacgc atatcttgaa aagctgaaat ccatcatcca 655261 atatacaggc gtttctgact gtaaaatgga agaaggctca cttcgctgtg acgccaatat 655321 ctctcttcgt ccgatcggcc aagaggaatt cggcacaaaa acagaattga aaaacttgaa 655381 ctcctttgcg tttgttcaaa aaggccttga gcatgaagaa aaacgccagg agcaggttct 655441 tctttccggc ggcgtcatcc agcaagaaac tcgccgttat gatgaagcaa cgaagaaaac 655501 cattcttatg cgtgtcaaag agggatctga cgactaccgt tacttcccag agccagatct 655561 agtcgagctc tacattgatg atgaatggaa ggaacgcgta aaagcaagca ttcctgagct 655621 tccggatgag cgccgcaagc gttatatcga agagcttggc ttgcctgcat atgacgcaat 655681 ggttctgacg ctgacaaaag aaatggctga tttcttcgaa gaaaccgttc aaaaaggcgc 655741 tgaagctaaa caagcgtcta actggctgat gggtgaagtg tcagcttacc taaacgcaga 655801 acaaaaagag cttgccgatg ttgccctgac acctgaaggc cttgccggca tgatcaaatt 655861 gattgaaaaa ggaaccattt cttctaagat cgcgaagaaa gtgtttaaag aattgattga 655921 aaaaggcggc gacgctgaga agattgtgaa agagaaaggc cttgttcaga tttctgacga 655981 aggcgtgctt ctgaagcttg tcactgaggc gcttgacaac aatcctcaat caatcgaaga 656041 ctttaaaaac ggaaaagacc gcgcgatcgg cttcctagtc ggacagatta tgaaagcgtc 656101 caaaggacaa gccaacccgc cgatggtcaa caaaattctg cttgaagaaa ttaaaaaacg 656161 ctaataaaaa agcagccctt agaggctgct ttttttatgg tcaaattgag ataaagacaa 656221 gatgagggcc cgaagccttt caacttcttt gtcgttggtt ccggccaaat tggacagcat 656281 gcctttaata atcggcttgc gcggtttatc ctgagtcaat tcttcctcga taacatcaag 656341 tgacacggtg atatcctcgg gcagcgtgct gttttctttc actttctgaa tgtcctcaag 656401 cagctggtct tttcccgcag gcatcgggtt aaaaatgtct tttgatacaa tcggattgag 656461 tgcagaacgg ctcagcccct gtacaagatc atccagtctc tcaataataa aggctgagat 656521 ttcttctgca tcgatattaa gctcaccgtt aaataccatc acgttcatat aggaatgcac 656581 aatgcctctt gccatgatgg acagatctgc gacataccgc tcgattcctt cgccatagga 656641 taccagcaag gcgttccggt acagcttatc cgtctccatg gttactttgt aaaagtattg 656701 cttgatttct tgattttccg gaatgatatt ttcggtaagc aaaagaacga taaaatcttt 656761 atgatcgcga aaatcctcaa attgagcgcc aatttgcttt tttaacactt ccttaggcgg 656821 ctttccggcg agatcttctt ctatattttt cattttgttc atagacatac cgatataata 656881 ttcacaggca gataacagca gcgcttcttt cgatttgaag tgcaaataaa aagcgccctt 656941 cgaaatgccg cattcactgg cgatttcttg gatcgtcgta gctgcgaatc cttttttcgc 657001 aaataaacga atgctggttt ttatgattct ctcttttttt tcattcatga cgtgcttccc 657061 cttaatcctt gaaaaattta gtaaaatttt ctggtatatg agttgacgtt gttgcgttat 657121 aacgtttagt attatataga atgaccagtc agtcaataaa aaatgtaatg gaggatatga 657181 tgaaccacgt tattaatttc gttctgaaaa acaaattcgc cgtatggctg atgacgatta 657241 ttgtaacggc agccggcttg tatgcgggta tgaatatgaa gcaagagtct attcctgacg 657301 tgaacatgcc ttacttgacg atcagcacga catatccggg tgcaacacca agccaagtgg 657361 ctgatgaagt gaccaaaccg gttgaacaag ccgtacagaa cttggacggt gtcagcgttg 657421 tgacgtcgac gtcctatgaa aacgcatcgt cggtcatgat tgaatatgat tatgagaaag 657481 atatggacaa agcgaaaaca gaagcagctg aagcgttaga aaacgtcaac ctgcctgatg 657541 acgcgaagga tccggagatt tcacgctaca gcttgaactc attcccgatt ctgacgctga 657601 gcgtgtccag tgataaagat aatctgcaag agctgacgaa acaagtggag gacagcctcg 657661 tttctaagct tgaaggcata gaaggcgttg cgtccgtcca agtatcaggc cagcaggtgg 657721 aagaggttga attctctttc aaagaagaca aactgaagga atacggcctt gatgaagata 657781 cagtcaagca agtgattcaa ggttcagatg tgacaactcc gcttggattg tacacattcg 657841 gaaatgaaga aaaatctgtc gtcgtcagcg gcgatattga aacaattaaa gatttgaaga 657901 atatgagaat cccgacggca tctgcttcaa gtgcaggcag cagcgcagca tctcaagcag 657961 gtgcgcagag tgctcaagca gcccaaagcg cgcaagcggc agcacaggtg cagcaaagcg 658021 caagcacagc agtgccgacg gtcaagcttt ctgacattgc tacaattaaa gatgtgaaaa 658081 aagctgaatc cgtttcacgc acaaatggca aagacagcat cggcatcaac atcgtcaaag 658141 caaacgatgc gaatacggta gaggttgccg acgatgtcaa agctgagctg aaaaagttca 658201 aagaagacca taaaggcttc aattacagcg caactctcga catggcggag ccgatcacac 658261 agtcagttga cacgatgtta agcaaagcca tcttcggtgc tatttttgcg attgtgatta 658321 ttctcttatt cttaagagat atcaaatcaa cattaatttc tgttgtttca attccattat 658381 cattgctgat cgcactcctt gtgctgcagc agcttgatat cacattgaat attatgacgc 658441 tcggcgcaat gaccgttgcc atcggacgtg tagtcgatga ctccatcgtt gtgatcgaga 658501 acatttaccg ccgcatgaga ctcaaagatg agccgctccg cggaaaagcc ttggttcgtg 658561 aagcgacgaa ggaaatgttt aaaccgatca tgtcatcaac gattgtgaca atcgcggtat 658621 tcctgccgct cgcacttgta ggcggacaaa tcggtgaatt gtttattcca tttgccttaa 658681 cgattgtttt tgcgcttgcc gcatccctag tgatttcaat cacgcttgtg ccgatgctcg 658741 cacacagcct gttcaaaaaa tcattaaccg gtgcgccgat taaagcgaaa gaacacaaac 658801 ctggcagact tgcaaacatc tataaaaaag tattgaactg ggcgctgagc cacaaatgga 658861 tcacgtctat catcgcggtt ctgatgctcc ttggaagctt gttcctcgta ccgttaatcg 658921 gtgccagcta cctgccgtcc gaggaagaaa aaacgatgca gctcacatac agcccagaac 658981 cgggtgaaac gaaaaaagaa gccgaaaatg aagctgaaaa agcggaaaaa atcctgcttg 659041 accgcaagca tgtcgatacg gttcagtatt cattaggctc tggcagcccg cttgccggag 659101 gagattctaa cggtgcgtta ttctatatca aatatgaaag cgacacacct gactttgata 659161 aagaaaaaga taacgttctg aaggaaatcc aaaagcaatc tgaccgcgga gaatggaagt 659221 cacaggactt cagctcttca ggcaataata acgaattaac atactatgtg tatggcgatt 659281 ctgaaaacga tattaaagac acggtcaaag acattgaaaa aatcatgaaa gatgaaaagg 659341 atctgaaaaa cgtaaattca ggcctttcca gcacatatga tgagtacaca tttgtcgctg 659401 accaagaaaa actaagcaag ctcggtttaa ccgcgtctca aatttctcag gccttaatgt 659461 cacaaacatc gcaagaaccg ctcaccactg tgaaaaaaga cggcaaagag cttgatgtga 659521 acattaagac agaaaaagac gagtataaga gtgtgaaaga tttagagaat aaaaagatca 659581 cttccgcgac tggccaggaa gtcaaaatcg gcgatgtggc aaaagtgaaa gaaggatcaa 659641 catcagatac cgtgtcaaaa cgtgacggaa aagtctatgc agatgtcaca ggtgaggtta 659701 cctctgacaa cgtcacagcc gtatcagctg ctatccagaa gaaaatcgat aagcttgacc 659761 accctgataa cgtatcgatt gacacaggcg gcgtatcagc ggatatcgct gattccttca 659821 cgaagctcgg tttagcgatg ctggcagcaa tagcgatcgt ttaccttgtg ctcgtgatta 659881 ccttcggcgg agcactagcg ccatttgcga ttctgttctc attgccgttc acagtcatcg 659941 gtgccctggt cggactttac gtatcaggtg aaacgatcag tctgaacgcc atgatcggta 660001 tgctcatgct gatcggtatc gttgtcacga atgccattgt cttaattgac cgcgtgattc 660061 ataaggaagc ggaaggcctg tctacgagag aagcgctcct ggaagccggc tctacacgac 660121 tccgtccgat cctgatgaca gccattgcga caatcggcgc cttgattcca ttagccctcg 660181 gcttcgaagg cggaagccag gtcatttcaa aaggactcgg cgtaacggtt atcggcggtt 660241 taatcagttc aacgcttctg acgctcctga tcgtgccaat cgtatatgaa gtattggcga 660301 agttccgcaa gaaaaaaccg ggaacggaag aagagtaaaa aacaaaaagc ctcagctctg 660361 ctgaggcttt cagcttgttg aaaaaccctc gcattcgttg tcaggtctgc gcgtcggtgc 660421 tcacgaattc tacattcgct ccgctccaat gctccccctt cctagactac aagggttttc 660481 aatcaagctg aaagaatgtt aaggatgaca aaagctcaaa acaagaatca gttttgagct 660541 tttgtgcgtt ttcacctgta agattatgta cattttgttg cgattttttt aactcatagt 660601 ataattaaag gttgttagtg taaaaatgga tcggatactc ttaagtagga tgatgagata 660661 atgaaacgtg cacgcataat atacaatccg acttcaggac gggagatctt taaaaagcat 660721 cttgcccagg tcctgcaaaa atttgaacaa gccggctatg aaacctccac ccatgcgacg 660781 acatgcgcag gagacgctac acacgctgcc aaggaagcgg cattgcgtga gtttgacctg 660841 atcattgcgg caggcggaga cggaacgatc aacgaggtcg tcaacgggct tgcgccttta 660901 gacaatcgtc cgacactcgg tgtgattcct gtcggcacaa cgaacgactt cgccagagcg 660961 ctcggaatcc cacgcgagga tattttaaaa gcggcagata cggtcattaa cggcgttgcc 661021 cgcccgattg atatcggaca ggtcaacggc cagtatttta tcaatatcgc cggcggaggc 661081 cgtctgacgg agctgacgta cgacgtgcca agcaaactga aaacaatgct cggccagctt 661141 gcttattatt taaaaggaat ggaaatgctg ccttcacttc gtccgacaga agtcgagatt 661201 gaatatgacg gcaagctgtt tcaaggtgaa atcatgctgt ttttggtcac gctgacaaac 661261 tccgtcggcg ggttcgaaaa gctcgcgccg gattccagcc tgaatgacgg catgtttgat 661321 ttgatgatac taaagaaagc aaaccttgct gaatttatca gggtcgccac gatggcgctt 661381 cgcggagaac acatcaacga ccagcacatt atttatacaa aagcgaaccg cgtgaaagtc 661441 aatgtatcag aaaagatgca gctgaacctg gacggcgagt acggcggcat gctgccgggc 661501 gaattcgtga atctgtaccg gcacattcac gtcgtcatgc cgaaggagaa agcggaacag 661561 ttggatgact aaaacttggc ttggtaagcc aagctcagaa tgttgacaaa atcctaaaac 661621 agttttcgtt ttaggatttt gtcatctttt cagcgtgatt gaaaaccttt gaagtctagg 661681 aagggcgagc atcggagcac agcgaatgtt gaattcgtga gcaccgaagc acaggcctga 661741 caacgaatgc gaaggtttgc ctacacgctg aaacttggct tgaataggcc aagtttttct 661801 ttcgcttaaa actagaggtg attatagatg aaaatgaaac ccccagtaga aaaaaatgaa 661861 tactacgatg tgacatttga ggatttgaca catgaaggag cgggcgtcgc aaaggtccaa 661921 ggcttcccga tctttgtgcc gaatgcccta cccgaggaaa aagcccaaat caaagtgaca 661981 cgcgtcaaaa aagggttcgc cttcggccgc ctgattgagc tgaaggaaga aagcccgcat 662041 agaacggacg ccccatgccc gatttacaaa caatgcggag gctgccagct tcagcacatg 662101 acctacgaag gccagctcct gtttaaacag aaacaagtca aagacgtctt agaacgcatc 662161 ggcaagctgg acctttcaaa agtcaccgtg cacccgacac tcggcatgga agacccgtgg 662221 aactacagaa acaaagcaca ggtgccggta ggagaacggg aaggcggact cgtcgcggga 662281 ttctatcagc aaagaagcca tgacatcatc gacatgagcg cctgcctgat ccagcaatcc 662341 aaaaacgacg aagccgttca agctgtcaaa gacatttgcg caaactacgg tgtcaaagcc 662401 tacaacgaag aacgccacaa aggctggctc cgccacatca tggtcagata cggcgttgtt 662461 acgggcgaaa tgatgatcgt cttcatcaca agaacaagcg acttcccgca caaagcgaag 662521 atcatcgaag acatcacagc gcaattcccg cacgtcaaat ccatcgtgca aaacatcaac 662581 ccaaacaaaa caaacgtcat ttttggcaac gaaacaaacg tcatctgggg cgaagaatac 662641 atctacgacc tcatcggaga cgtcaaattc gccatctccg ccagatcgtt ttatcaggtc 662701 aacccagagc aaacaaaagt gctctacgac aaagcgcttg agtacgctga gcttcaaggg 662761 gaagaaaccg tcatcgacgc ttactgcggc atcggaacga tttctctctt cctggcaaag 662821 caggcgaaaa aagtgtacgg tgtagagatt gtgccggaag caattgagga cgcgaagcga 662881 aacgccgaat taaacggcaa cacaaacgca gagtttgctg ttggagaagc ggaaaccgtg 662941 attccaaagt ggtacgaaga aggcattaca gctgatacgc tggtcgtcga cccgccaaga 663001 aaaggctgcg acgaagccct cctgcggaca attgtggaga tgaagccgaa gcgggtagtg 663061 tatgtgtcct gtaatcctgg cacgcttgcg agagatttgc gggtgcttga ggatggcggg 663121 tacgtgacgc gcgaagtgca gcctgtggat atgtttccgc atacgaatca tgtggagtgc 663181 tgtgtgttga taaaattaaa agaataaata gtcaaaaatc tatgctgatg gaactgttgg 663241 ttctctaaaa cgataattga tttcaatggt tccatttgca tgtacttcta tttcatctac 663301 taacaaatga agcatttcgg gggtaagtgt accttccttc atgaatttat ctaagctctt 663361 tttaaaatca attatttctt tttcaatctt ttgaaattct aggtccttag atagttggtg 663421 aagggtagtt tcaaaatttg aaatatcttc attggtgata tttatggcta attggtaatc 663481 ttctttagat ataacaccat tagcaagaga gataactaaa ttggatttat ctctcttttt 663541 atcgtttaat ttttcattaa tttcgattat cttagattcg attttttctt tgtactttaa 663601 cgctttttca cttaattctt taaaataatt ttccttactg aatttcaaat atatcttatt 663661 taggttggtt attactttat cagttaaatc tatttcactt acgtaatgat cactacatgc 663721 ttttaaacca tgtttattat aacttccaca aacataacct tttcgattct ttttaaaatg 663781 cattgacctc ctgcaatctt tgcaaaccgc agtatttgta aagagatgta cttcagcttg 663841 aggtctcctt ctttttctag ttattaaaat ctcttgtaca ataagaaagt cttctaaagg 663901 tatgattggt tcgtggcttt tttcaataat tatttggttt tctaggttaa ctgaccttct 663961 tcttttactg gtaacactcg gtctatattc tctacattgt tgtagtgtcc cagtatagtg 664021 aggattttcg agaatttttc ttattgaaga tccgtgccat ttgtcagtag cgttcttttt 664081 gcgggcaagc tgcgagggac tagtgacccc ttcgttatac aatccccttg ctattgcatc 664141 aaagcctttt ccagcaatat attctgaaaa gattctaata tttactattt tctctgcgtt 664201 tgctgaattt gagagagata tgattgtaga acgaactcaa gaaggtaaaa tgttggccaa 664261 gcagaatccg gatttccgag aaggaagacc caaaaagttc acaaagcagc aaatcaatca 664321 tgcattaaca ttactagaaa atcattcgta taaacaagtt gaagatatga ctgggatatc 664381 agtttctaca cttgtaagag ctaaaaagaa gaaagctgct gaagctataa atggataaat 664441 attgtgaatt aattattcaa tatcttgaga aatttttata aaagtaatca aaagtttaat 664501 gggggaaacg aaatggcgct cattgattta gaagataaaa ttgctgaaat agtgaatcga 664561 gaagatcatt cagatttctt gtatgaatta ctcggtgtat atgatgttcc acgagctaca 664621 attacgcgct tgaaaaaagg aaatcaaaac cttacaaaac gggttggtga agtacactta 664681 aagaataagg tgtggtttaa ggaggctaag aaaggaaagc tctttgacgc ccttattgat 664741 atagaacaac aagttgaata tctttcagct aagccacgat atttattagt tactgactat 664801 gatggagtat tagcgaaaga tacaaaaaca ttagaggctc ttgatgttaa atttgaagaa 664861 cttcctcagt atttcgattt cttccttgct tggaaaggta ttgagaaagt agagtttgaa 664921 aaggaaaacc ccgctgatat taaagcagcc gaacgttttg cacggatata tgatgtactt 664981 cgtaaagaaa acaatattat tgagactaat agagggttag atttatttct tattcgttta 665041 ctgttttgtt ttttcgcaga agatactgac atcttcaaac gaaatagttt tacgaattta 665101 attaagactt tgactgaaga agatggttca aatctaaata aattatttgc tgatttattt 665161 atcgtgttag ataaaaatga acgagacgat gttccatctt atttaaaaga gtttccgtat 665221 gtaaatggcc agttgtttac tgaaccacat acagagttgg aattttctgc caaatccaga 665281 aagttaatta ttgagtgcgg tgaattatta aactgggcta aaatcaatcc tgatatcttt 665341 ggttcaatga ttcaagctgt tgcttctgaa gaaagccgta gttatttagg tatgcactac 665401 acaagtgtcc ccaatataat gaaggttatt aaaccgcttt tcctagataa acttaatcag 665461 tcttttttag atgcatacga tgattataca aaacttgaaa atcttctaac acgaatcggc 665521 aaaattaaat tctttgatcc tgcatgtggt tcagggaact ttttgattat tacctacaaa 665581 gaattacggc gtatggaaat caatattata aaacgacttc aagaactctt gggagagtat 665641 ctttatgtac cttcagtaac tttatctcaa ttttacggaa tagagattga agattttgca 665701 catgacgttg caaaattatc actttggatt gctgaacatc aaatgaatga agaattaaaa 665761 aatgaagttc ataatgcagt acgcccaacg ttaccacttc atacagcagg ggatattcgt 665821 tgtgcaaatg ctattagggt tgagtggact gaggtttgtc ccgcacaagg atctgaagaa 665881 gtatatgttt ttggtaatcc accgtatctt ggttcaaaaa aacaaaacaa agaacataaa 665941 tctgatatgt tatcaatttt tggaaaagtc aagaatggta aaatgcttga ttatatttct 666001 gcttggtttt actttggtgc taaatacgct tcaactacaa atgcaaaagt tgcctttgta 666061 tcaacaaatt cagttactca aggggaacag gtttctatct tatggaatga gttattcaag 666121 tttggaattc aaatcaattt tgcctataaa tcttttaaat gggcgaataa tgctaaaaat 666181 aatgctgcgg taattgttgt gattgtaggt tttggcccgt tagataccaa agtaaacaag 666241 tatttatttg ttgatgaaac gaaaaagcta gtttctaaca ttagtcccta tttaactgat 666301 ggtgaaaata ttcttgtttc ttctaggacg aagccaattt cagacttacc caaactgcat 666361 tttgggaaca tgcctaatga tggcggagga ttactcttta ccattacgga atatacagac 666421 gcaatcaata agtatcctga attagttccc tattttaaaa agtttatagg ttcagtagag 666481 tttattaatg gtggtttacg gtattgttta tggcttaatg aagcaaaata tgaaaaaata 666541 aagtctaatc ctctaataca agaaagaatc tcaatttcaa aaaatcacag ggaaaaatca 666601 acagataaag gaacgaataa acttgcatta actccgtgga agtttagaga tactcatgaa 666661 acaactaatt attccattgt tgttccatct gtgtcttctg aaaatagatt ttatattcca 666721 atgggattag caggtgcaga tacaattttg tcaaatctaa tttatgtaat ttacgatgca 666781 gaaatttacc ttctaggcat tttgatgtca cggatgcata tgacttgggt aaaagctgta 666841 gccggaagat taaaaactga ctataggtac tctgcaggtt tatgttataa cactttccct 666901 attcctgaat tatcaacaag aaggaagaat gaaattgaag aagcaattct tgaaattctt 666961 gatcttcgtg aagagcaggg tggtacatta gcagagcttt ataacccttc aacaatgcca 667021 attgaattaa aagtagcaca tgaaaagttg gatggaattg tagaaagagc gtatcgtcaa 667081 aaacaatttg aatctgatga agaacgctta gaagtattgc ttaaattgta tcaagaaatg 667141 acagaacggt aggtgtaagg tgtatggaaa atataattga aattaattat aaccaaactg 667201 gtaaaagtaa gaaaacaaat gaatacggta tgcgtgaaat gcaggcaaga gcttttgaaa 667261 aacgtaactc acaatatctc ttagttaaag caccgccagc ttctgggaaa tctagagctt 667321 taatgtttat cggtttggat aagctcataa atcaaggttt gaggaaagtg attgttgctg 667381 tacctgaacg ctctataggt tcttcattta aaaatacgga tttaaaaagt tatggtttct 667441 ttgaaaattg gaaagttgat cctagaaata atttaactgt tggcggagat aactctaagg 667501 ttaaatcttt tgttcgtttt atggaatcgg acgatcaggt gttaatatgt acgcactcta 667561 ctttgcgatt tgcgtttgaa aaaattgatg ataaagcatt tgataattgt ttacttgcaa 667621 tagatgaatt tcaccatgta tcggcagatg tcaattctcg attaggtgaa ttgttaagaa 667681 gtattattca taattcatca gcacatattg tagcgatgac tgggtcgtat ttccgtggag 667741 attctgtacc aattttatta ccagaagatg aggaattatt tgacaaggta acttattcct 667801 attatgaaca acttgatgga tatgaatatc taaagggatt tggtatagga tatcacttct 667861 atcaaggcca gtacacatca gctattaatg aagtattgga tacaaataag aaaacaatcg 667921 ttcatattcc aaatgtaaac tcaggggaat cgacaaagga taagtacgat gaagttggta 667981 agatacttga tatgattggt gaagttgaat atcaagatga tgatactgga attatttatg 668041 ttaagcgaca ttctgacggt aaaacattga aaattgcaga tttagtagat gaccaagttg 668101 gaagagaaaa tgtcgttgcg tatttgcgta atattgaagc cctagacgat ttagatataa 668161 ttattgctct tggtatggcg aaagagggct ttgactggcc gttttgtgaa catactttga 668221 cagttggtta tcgtggctca cttacagaaa tagtacaaat aattgggcgc tgtacacgtg 668281 atagttacaa taaaacctat gctcaattta ccaacctaat cgcaatgcct gatgcaaagg 668341 atgaagtagt gacttataca gtgaatacaa tgcttaaagc tatttctgcc tcacttttga 668401 tggagcaggt ccttacacct gactttaaat ttaaacgtag aagaaatgaa agtgaaaaat 668461 cttctactac aggagaatta ttcgttaagg gattgaaaga accatcaaca gaaaatgtca 668521 aaaagattat tgaaaatgat attaatgatt taaaagcaaa aatcatgcaa gattcacaag 668581 tccaaaaaac atttagtgga gaagtagatc ccaaagtatt gaacaaagtg ttgattccga 668641 aagttattca aaaagtatat ccaaatttat cagatgagga aattgaggaa gttagacagc 668701 acgttgttct agatacagtt atgaaaggtg ctaagtctga agttgtagga agtaaagaat 668761 ttataagaat ggcagataag tttataaaca ttgaggattt agatatcaat ctgattgatt 668821 ccatcaatcc gttccaaaaa gcatttgagg ttctatcgaa agaattgaac tcaccagtgc 668881 taaaactgat tcaggaaact attgatgcaa aacgtattaa ttttgatgaa gatgaactag 668941 tattcatatg gccaaaggtt taggaatttt atcgttcaac tggtagaaga cctgattcaa 669001 aatctgaaga cccacttgaa aggcgtatgg gtgaagctgt attatacatg caagagctta 669061 ggaggaaacg tgaaaatggc aagtaataga taccattcta ttaatgaaat catggaaagt 669121 cagctgtttt accaaatcac aacaccacct aagaaaacac aaaaagccca gtatgatcct 669181 gaagttgaaa agtttttgga gattattgaa ttcgtcaaag aaaatgggcg agaaccccaa 669241 aaagtcccta ctgatttaac tgaaagaagt ttagcaagtc gattaattgg gattcggaaa 669301 gatcctgatc gtatggaata tttgaaagag tatgatgaaa ttggattact tgaagtaaga 669361 tcgaaggaac taacaattcc taaaatttct tcaattgatg atattctaaa aagtggctta 669421 tctgcattat taggtgataa tttaaataat gatataacta ggtcaatttt tgatacaagt 669481 tcacttcaaa aggttacgac aatgcctgaa tacgttgcaa agcgtaaaaa aataaaagat 669541 tttggaaagt ttgaagagct attcaagaag tgccacaagg aaattacaga gggtaaacga 669601 aaaattttaa ctttcaaaaa tgaacaagac atacagtcaa atagttttta tatattaaaa 669661 ggagttcttc tttatgttga agatgtggga gaacgtaaaa aagcaaaggg aaaaaccaat 669721 gctagacttc gatgtatatt tgaaaatgga acggaatcag atatgttact acgttcctta 669781 tcagcggagt tatataaaca tggtagacgt gtgaccgaca atgaagatac attgttggat 669841 aatgttagag aagatgatgt ttcgactggc tttatttacg tactaaaatc tttgagtaca 669901 gatccgcaaa ttagttccat taagaattta tataagatcg gttttacaac tggttcagta 669961 gaaaatagaa tcaggaatgc agaaaatcaa tcaacttatc tttatgctcc agtagaaatt 670021 gtaaccacat atcaagtgtt caatatgaat gctagcaaat ttgagacggc aatccatcat 670081 gcgctagcaa ataataattt ggatgtttct attttggggg caaatggaaa gatgttagtt 670141 cctaaagagt ggttcgttgt cacacttgaa gatttacaag ctgtaataga tgagattgtg 670201 atgatggttc atctttatga ctaaattagt atattaggat tttagtatta ataataattt 670261 tatagtagac tatgaaaaaa tttgatgcca taacaataac ttgttccgct ttggagtttg 670321 tcacaattgt agaattatgt gttgcgagta ttaataggaa ggggttgagc gaccgcaaaa 670381 aaaattttcg gtgctgtccg caaaagggag tttgggtgtt ttgcgttata tttggttgtg 670441 tgaaggttag cggaaactca attcgtgaag ttaggattgc ggttattacg actgagtagt 670501 ttcgtcatac tcttttagca gtttttctgt cttatgcatt tctttgagca tcggattcat 670561 gtagtcgtta gctgattcta gatatgctct cgtcagagtg tctagtttat ttctaacttt 670621 agagaggtct tcttcgaatt ttccatccga tgattgaagg ataaattctt ttgcctcttc 670681 atatcttttt aatatgtttt tcaccattgg agttggattc ttttgattta ttgtttttat 670741 tacagtgatt gttaaattta tttgttttat taattctttt cttactgtca aggtgatgct 670801 ccttttaaat ctctattcta tttgagagtt gctatatctg tttaatggtt tgatagacta 670861 ctcatcttta taatttagag caatttttac aacttgttcc gctgtgtaat cttcattgct 670921 ccagaaaatt aaatcacttg gtgccggata aggaacattt ttctctaata aatcgagata 670981 ttcactgact ttctcatcat ctaatgttgg gttcattaat tcctttacaa gaaagatcaa 671041 ctcttctttt gtcagtttat ccattgtttg ccctccaata gattgtatct ccattgattt 671101 tacaaatgac tttatttctt ctgataatgt tataggttgt ttgcataatg atagataatt 671161 gtcttgagaa aagttagtct cattatagag tttattaatt gtatttataa caatatattc 671221 atatggaaaa cctctaaaat atctttattt tagattggtt tataaaaaat agctcagcag 671281 agtagggctg agccattttt taattataga ccgaggtaac taattacaaa ttctttatca 671341 tcctcatctt caggcaaaat accaaggttt ttatattccc atattgcgat tctttcatat 671401 ccatctaatt ctgaggctaa aatatcatca taattataat ctaattggaa ttctccgcta 671461 cgatccaatg ttagtgtaag gttagtccaa acatcatcgt tattatttct gtgttcagtt 671521 cttaattctt caaaaagttc tcttagttct cttaacaacg tcttgaaaat atccttgctt 671581 acgttgtaat ggctaggtat atcttgtgaa taaataattt gattattttc tggtgttctg 671641 aaatgaaaaa gaaccattgt ggaatcatct aatacttctg cataaagata tatctttgtc 671701 cattcaccag gtatgatgtc attgagtttt tctccaataa gttgatacaa atcttgcatc 671761 ttcctagttt ccattcttct aacccccagg ctgattttta atagagacgc ttatttcttt 671821 tctgctccca attttgtagg ttacatcgaa atatgatggt ctaagtgaat ccccagaata 671881 gactggttct atttgaactg ctactttttt aggtggtttt ttgcttaggg cttttgccca 671941 ctcctgctcc atctcatacc atttcccacc gctcctatta atctgagaat tcatcggcac 672001 gatattgtca aactggcctg agcctttgaa ttgggtggcg attaaatggc cgccgtcatc 672061 gtcaggcttt cggtcctggg gctttccagc attcgtttgt gcatattggt ttcgtttcgc 672121 ttctcccagc tgcaagtctg ctttgacact tgtaattcta ccatagttgt cagtcgtgta 672181 cgtgtagcct tcttttgttt tgtagatgat attaggcttc agcactttct ttctgctcca 672241 tcttgcgaaa tgctcgccgt atttgacggt taccggcggt acatgtggcg ctggagttcg 672301 tcttccgctt gatgacgttc cgtatggttt cggcaggatg accttggcga atttttgcag 672361 tccttcttta agcgtgaccc cgttgactgc gttgtaagga acgcctgccg gcactaaatc 672421 atgacgggga tgatacggga gaatatccgc aagtgtgaga tctccgattt gatttaactt 672481 ggttttgacg tgtttttttg atacttcaat gcctgtgttt actttttgtt tgatgtgatc 672541 aacggtttgt tttgagactg ttatggcttt ttgggctgtt gctgatttgc ttgctgctgt 672601 tttgactttg gtcgtcactt tggcggctgt gccagttttt gagacggctc ctacgccttt 672661 tgtgccgaca attgatgtga caacagtgcc aaccgcatat gacacccatc ttgctcttga 672721 gtaggtgtca ccattcacca tgtctttttg atacgattct tcgattgccg ctgaaatggc 672781 ttcatacgtt ttgatcgggt gagccatcgc tccggtaatc gcttcaacgg ttcctcccgg 672841 atctgtgacc atatcccaca ggcctacgac cgcgtctttc ccggaatcat aaaggccgac 672901 ggcaacccct ttgaagcctg cttcaagctc acgcgtgttt tcaatttggg tgaagtatct 672961 ctgttgttca gctgtcagat tttcatagcc gatcgttttt gccatttcgt agaattcatc 673021 ggcatctgca taatcgtagt ttttcagtct ttctttcagt ttctcaatct cgcgttcctt 673081 cgcttcctct ttcttaatct tcaagtaagc ctcagtccgc ttttcaatgt cgcctttttt 673141 cttatgtatg tcactctcac ggtacgcctt ggcgttgtag tggatgggtg tggcgttttt 673201 gcctttaccc gttgcttctt ggagcttttg gaagtcggat ttgatgaatt gttcgtttgg 673261 ttcagacagg gcgtattctg ttttcaggtc ttcgtccaag gcgtccaatt tttccagtgt 673321 ttttttgcgt ttgtcgttgg catcggccag ctcgtctttg aaggtttctg ttgaaaacag 673381 gtcgagcggg aggatgtcgt cgatatcgtt taggatgtct ttcatcgctt ttttctgttc 673441 ggacatgatg gatttagatt ttttattggc atttgccagt tcgtgctcca ggaaggattc 673501 ttcgatgtat gcgtctgaga ggcctttgtc ttcggcggct ccggcgatgc tgttgaaaaa 673561 tgcgattttc atgtcgatgt agtcgatcca ctggtcggcg acgccgacgt ggtcgtgata 673621 gaatgccttg atgttgctgg cgccttttcc tgagaattca ctgtcactga gatcagcgac 673681 tccttttaac gcttttctca agttgaccat ttgcgttctt agttctttgt actcttttgc 673741 acggtctgtc gcttccgaaa gcagtgtttt cgcttcaaat actttcatga ccatttccct 673801 tcttttgttc gctcaatatc aaaattttac cacgggtcgg gataaggtgg gggtgagaac 673861 gtgttttggt ggaaaaatga gtcatttggc atgtgtcttt attcgtggag ggattggagg 673921 aaacatggtc gaaatgatat tgattgctac acattttttg gaagtttgta ttctatattg 673981 ttttttaagg agcatgttga tgacgaaaaa acggattaca tttggtttat tagttttaat 674041 ggtatgtgtc atcctgtttg ttctgtatgt tcagttacgc aataaagata gtattcctgt 674101 ccaatcttcc gccattcacc ccgaagaaga ccgcatcttt tttatttact ccaatccttt 674161 cataaaagaa agcgtgctgc tttcaacctc tacaggcgaa cggtttaaca ggcgtacgtt 674221 taaggtggcg gatgtgcctt atattcaaac gaaatcttat gcatcaacag accttgtatt 674281 attggcggaa cacgagcctt tttactacac gctggagaag gatgtgatca aagagcatcc 674341 gctgtcagat ccatttgcgt tttggtatga ggggaaggat gtcactattg aggcctataa 674401 tgttgatacg acgggaaatg agatccacat aaacgacaga aaaacgaaaa aggaatatac 674461 ccttaccttg cctccgcttg tcacaatggg ggccagtgat gagaacttta tttatatcat 674521 tcaaagcatg tctatttacg tgattgacag aaaaacagag gaaatgattg agaccctgag 674581 cttagcctca tacgctgatc aattcgcaga ctcggaggaa tttatcgtcg cgagctcgga 674641 tcataaattg actgtgattg aaaaagggac atggaagacg acatatattg cgtatcctga 674701 agatcttgaa tatgcagata ctgtgtacta tgacaaagaa agcggcagtt tttacgtggc 674761 gtacgaggac aaagagggtg gagcgaactt gctggaatat ggggaggatt tttctattca 674821 cacatacagc ttgaaattcc cttatatgga ggcgaagttt aaggggaatc tattgtatat 674881 agttgcccag gaagagcata aaaagggcat cggcggatac gtgggtgtgt ttgatatcca 674941 ttctaaggag atgctttatc agtttgattt gcctgaggaa caggtgaagg ttcaggattt 675001 tgttgtggtt gacaataagt gaatactata tgaaatagaa tgacaaagac ccttgcataa 675061 agggttcttt tttatgaaaa aaacaaattg acaggatgaa aaaacaattt cttccttcta 675121 tattgttttc aaaatttggg attgatagaa tatgacatat ctcatagaga aggagggaag 675181 ccgttgagtc aagccatacc gtcttcgcgt gttggtgtta agattaatga atggtataaa 675241 atgattcgcc agttcagtgt tccggatgct gagattctga aagcggaggt tgagcaggac 675301 attcagcaga tggaagaaga tcaggattta ctgatctatt attctctgat gtgttttcgg 675361 caccagctga tgcttgatta tttggagccg ggaaaaacat acgggaatcg ccctacagtg 675421 acagagcttc ttgaaacgat cgagacccct cagaaaaaac tcacaggtct tttgaaatac 675481 tactctttgt ttttccgcgg catgtatgaa tttgaccaaa aagaatatgt ggaagcgatc 675541 ggatattatc gcgaggcgga gaaagaactg ccgtttgtgt cagatgatat tgagaaagcg 675601 gaattccatt ttaaagtggc agaagcgtat tatcacatga agcaaaccca tgtgtcgatg 675661 tatcatattc ttcaagcctt ggacatttat caaaaccatc ctctatacag cattagaacg 675721 atacaaagct tgtttgtgat cgccggcaac tatgatgatt tcaaacatta tgataaagcg 675781 ctcccgcatt tagaggcggc gctggaattg gcaatggaca ttcaaaatga caggtttatc 675841 gccatttctc tattgaacat tgcaaacagc tatgacagat caggagacga tcagatggct 675901 gtagaacatt tccaaaaagc ggcgaaagta agcagagaga aagtgcctga tctgcttccg 675961 aaagtcttgt ttggattaag ctggacatta tgtaaagcgg gccaaacaca gaaggcgttt 676021 cagttcatag aggaaggatt agaccatatc acagcacgtt ctcacaaatt ttataaagaa 676081 ttgtttctgt tcttgcaggc cgtgtacaag gagactgttg atgaacgaaa aattcatgat 676141 cttttaagct atttcgaaaa aaagaacctg cacgcttaca ttgaagcatg tgcccggagt 676201 gctgccgctg tttttgaaag cagctgtcac tttgaacaag cagctgcgtt ttatcggaaa 676261 gtgctgaaag cccaagaaga tattctaaaa ggagagtgtt tatatgccta ttaagaaaaa 676321 agtgatgatg tgtctggctg ttactctagt tttcggaagc atgtcgtttc caaccctgac 676381 aaactccggt ggatttaagg aatcgacaga tcgaaatacg acgtatatcg atcattcccc 676441 ttacaaactt agtgatcaga agaaagccct tagctagggc tttttcttgc tttacggaag 676501 acgttccatt ttccacatcg cggcattcct tctatttcta acgcaagaca ctcgaaacaa 676561 ccaaaccatt tgaggtataa tggataaagt gaataacagt atttagattg atatatatga 676621 aagagagtgg aacatcatgg gccgtaagtg gaacaatatt aaagagaaga aggcgtctaa 676681 ggacgcaaat acgagtcgga tttatgcgaa gtttggccgt gagatttatg tggcggcgaa 676741 acagggcgag cctgatccgg aatccaacca ggcgctgaag gttgtgcttg aacgtgcgaa 676801 gacttacagc gtgccgaaaa acatcattga acgtgcgatc gagaaggcga agggcggagc 676861 ggaagagaat tacgatgagc ttcgttatga gggcttcggg ccgaacggat caatgattat 676921 cgttgatgcg ctgacgaata atgtaaaccg tacggcgccg gaagtgcgtg cggcgttcgg 676981 gaaaaacggc ggaaacatgg gtgtgagcgg atctgttgct tacatgtttg acgcgacggc 677041 tgtaatcggt gtggaaggca aaacggctga cgaagcgctt gaaatcctga tggaagcgga 677101 tgttgatgta cgtgacattt tagaagagga tgacagcgcg atcgtgtatg ccgagcctga 677161 tcaattccat gcggtgcaag aggcgtttaa aaacgcgggt gtcgaggaat ttacagtagc 677221 ggagctgaca atgcttgcgc aaagtgaagt aacgcttccg gatgatgcaa aggaacagtt 677281 tgaaaaattg attgatgcat tagaagattt ggaagatgtt cagcaggtat atcataacgt 677341 tgatttaggt gagtaaggag tgagcaggct gttatggcct gctttttttg tcccggaaat 677401 tgttttagct gtatgtaggc ggccgcctat acgatctata agatattctc atactctgga 677461 ctgtaaccta tgtgaaggag agagtaaata tgactgatac aagacatatg tatggcggac 677521 ctggttttgg tcattatcag ggctttggta ttggccaccc gggctatggc atgcaaagca 677581 caggctatcc gggctatggc atgtatggag gccacccggg ctatggcatg caaggctacc 677641 cagatcacgg catacatgga ggagtcggcg gctatccggg atatggtggg tacggcggtt 677701 acccaagcgg cggctatgga ggctctccgg gaactggaag ctatccgagc atgcaccatg 677761 aaaatgatgg ccatcaccac tattatcacc atcatcatga tggaaaagat aatcttcatc 677821 accatcatca ccatgttgga aaggataatc atcaccacca tcatgatggt cattatggcc 677881 accatcatca ccatatgggc cactggggaa aagacggtta taaataaaga agatgatgat 677941 aaaaagagga cactcttgca gatcaagagt gtttttttag cttttttctt gactgttcag 678001 tctggaaaat ggtaacattt gtttcaggag gtgatcattt tttggggagg aataaagaat 678061 ttgatacggc gcttgttctt cacagggcga tagaggtttt tggagagtat ggctacgaag 678121 gaacgtctct tcaggatctg ctctctcatt taggcattgc gcgccaaagt ttgtatgata 678181 cgtatggaac gaagcgtgat ttgtttttgt ccgctgtgaa atcgtatctt gaagggaaaa 678241 acgctgccgt tatggaaagg cttgaagcgc caggatctgt aaaggaagcc attcgtgata 678301 tttttcagga gggtgtcaat gccctgaggg atccggaacg ggcgaaggcg tgctacatta 678361 ttaacagcgc gattgaacag atcccgcatg accctgagct tgcccggtat tttgaaagac 678421 aatccaagca gcttgaggac gctttttatc acgggctttt aagagcgaag gatcaaggag 678481 aattgaatgg cgaagatact gatatatctg cgcttgctcg gtacctgaat cagagcaggc 678541 tgtcactgac atttattgca aaagtgacgg cagatatgga tcggcttcag gaccatgttg 678601 acgtgagttt atcagtgctt gattaacatg tggtaaagga ttctttgccc atgtatgtac 678661 tttttggact gaatagtcta gaaataaaaa tgaggtgatg atgaatgttg atgaatgagt 678721 ttgaaaaagc atgtgaaaca ttgagaaagt ttatggctta tatgcttgag aaggacatga 678781 agagctggac ggagctttgg gatgagaatg ctgtatttga gtttccttat gcgccggagg 678841 gatcaccaaa aagaatagaa ggaaaagcgg ccatttacga ttatattaaa gattatccta 678901 agcagattca tctttcttca tttaccgctc cgacagtgta ccgttcagca gactcgaata 678961 cggtgattgc ggagtttcaa tgtgacggcc atgtgattga gactggactg ccttatcgcc 679021 aaagctatat cagtgtcatc gaaacgagag acggccgcat tgtgcgttat agggattatt 679081 ggaatccgct tgttgtaaaa gaggcctttg gaggatcatt tttgcaaaca gaggagagtg 679141 ggaaatgatg aaacagaatc cgattttaat cacgggcggg accggcacag tcggcagccg 679201 aatcgccagc cgtttaataa agctgggata cagagtgcgt attgcaagcc ggaaaaaggg 679261 cgcgcttgct gatgctgagt atgtgtattt taattggaag tacgcctcca gttttacgcc 679321 tgctctggaa caggtaaaac agatctatct tgttgctccg gtcggtgtat ttgatccggc 679381 tccctatgtg cttccctttt taaaggaagc aaagcgtctc ggcgcaaagc gggtagtgat 679441 gcaaagtgcg tctgttgtct ccgagaacgg tcccgtgttt ggcgcgcttc accaggcagt 679501 gcgcgagttt ccagaatgga cggtgctgcg gccctcatac tttatgcaaa atttcatcaa 679561 tgtccagcac cgcatgtcta ttcaaacgga ggggcgcatc acaacggctt cgggtgaagg 679621 aaaacttggg tttattgacg ctgatgacat cgcagaaaca gccgtcaggg ctttgattga 679681 tgatgttcct catcaaacac atcatattct gacaggtccc gaggcgctga gctatgccga 679741 agcggcggag atcattggag ctgcggcggg acgccgggtg gagcatgtca gcatttctcg 679801 ttccgagctg cagcataaaa tggaggcagg aggtttgccc gcggattatg cccattttat 679861 ggcgaagctt gatgaggcaa ttagccatgg tgcggaacat cgggtaacgg atacagtgaa 679921 gcgtgtgacg ggaaaagaac ctcgttcgct gtcagagttt gcggctgctc atgctgcata 679981 ttggacctca ttttggactg aatagtctag aaagaccttc ggcgcttccg aaggtcttct 680041 tattgaaaaa gctaagtcgt gttttagtca taatcatgcc tcctgcctca tacctattaa 680101 ggtcattgtt tttgagaaag gaggagccgg aatgaaggat atgcagccgt ttacgcctgt 680161 caaatcatat acgccctttc acagccgttt tgatccctgt ccgcccatag ggaagaaata 680221 ttacagaacg ccccctaacc tttatatgac ctttcagcct gagcacatgg agcagttttc 680281 gccgatggag gctttgagga aaggcaccct ttggaaggat ctctatgatt tttatgaaaa 680341 cccttatcga gggggagacg cacatggcaa aaaaggttga cgccgaatat tatcgtcagc 680401 tagagcaaat acaggctgct gattttgtgc ttgttgagct gagtctttat ttaaatacac 680461 atcctcatga tgaagatgcg ttgaagcaat tcaatcaata ttccggctat tcaaggcact 680521 taaaaagaca gttcgaatcc tcttacggac cgcttctgca gttcggcaac agccccgcgg 680581 gcaaggattg ggattgggga aaagggccat ggccgtggca agtataagga ggaatgcctg 680641 aatgtgggtg tatgaaaaga agctgcaata ccctgtcaag gtcagtacgt gcaacccgac 680701 gctggcgaag tatttgattg agcagtatgg cggagcggac ggcgagctgg ccgcggctct 680761 ccggtatttg aaccagcgtt atacgattcc tgataaggtc atcggccttt taacagatat 680821 cggcacggag gagtttgccc atttggaaat gattgcgacc atggtctata agttaacgaa 680881 agacgccaca ccggagcagc tgcgtgaagc tgggcttggc gatcattacg tcaatcacga 680941 cagcgcgctt ttttatcata atgcggcggg cgtgccgttt accgcgagct atatccaagc 681001 gaagggcgat ccgattgccg atttatacga agatattgcc gcagaagaaa aggcgcgggc 681061 gacgtatcaa tggctgattg atatttcgga tgatcctgat ttaaacgatt ccctgcgttt 681121 tttgcgtgag cgtgaaatcg tacactctat gcgcttcaga gaagcggttg aaattttaaa 681181 agaagaacgg gataaaaaga agattttcta ataggcagat tggcctctct ttcatacacc 681241 cttttacata cagagaaaat ggtctgtttt tgcagtttgg tctgcattat aatcaaggtg 681301 tgtgtgcaag cttacttttt gattgggagg cctttatgac agcttttaag attgagaacg 681361 aaacgattgc agatggattt tacgcgtgtc cggccgtcta tgaggatgca gaatcgatta 681421 ccgggttgct cgtccgaaca gctgaatggc tccgggatcg gggttctaac caatggagcg 681481 gacttctcaa agggcaagat atacatgata tcacggggtc aattgaaaag ggacatgtgt 681541 ttgtgtttaa aaaagatgaa gagcttgcgg ctgtcgtgat gctgctgcct gcaccgagcg 681601 agtgggaccg gacgctttgg ggagacgatg ggcatgagga gtccatttat ttacaccgcc 681661 tcgcagtaag ccgccggttt gcgggacagg ggcttggagc ccgcgtcctt cagtgggcgg 681721 agacgggcat acactttccg gaaaaaacgc ggatccggct tgactgtgtc gctgatagtg 681781 acgccctgca ttccttttat cggcgtatgg gatatgaatt catgggtgct gatgcgtccg 681841 gatatcattt gtttgagaaa gagattacgg cagaataagc gtcctttgca gggggctttt 681901 ttgtcttttt ctaaaaggga ggcaggcgat gtgtggtcaa tattatttgt gacagggatt 681961 gtgacggctt gtctgtttgc tggcgtatcc gtattgatgc ggatgagatt tcctgacaaa 682021 agtcggccgg aatggatgtt ggccgggctg atcgtccttg gtgtgtttgc gatctggtac 682081 agcctcgtgt atgtacgcgg ctgggaaggg gctgcgctcg gaatgcttgg attcaatgtc 682141 attttcggag ccattgccgg atatttgatc gataaggcca tccggcgtta caggaaaaga 682201 taaggctgct gccgtctctc aacaggtcga aattttcaca gaccggcagg aattttcttt 682261 cgaaaggaga aatacatatt actttaaaat gaaagcgttt tccaaagcag gaaggtgatg 682321 ttgatgatac acagtgtggc aaatgggctg aatcattttt gtacgtgggt gatgagactg 682381 gcctatttga atgtgctttg gattttgttt tctcttgcag gcctggttgt atttgggctg 682441 atgcccgcta ctgccgcgat gtttacagtg gcgagagaat gggcgaaggg gaatacagat 682501 gccccggtgt tttctgtctt ttttcggacg tttaaaaagg aatggcgggc atcacagatc 682561 ctcgggctta tcgttgtgac ggctgccctg tttctgtttg cggatatgcg gatagcggct 682621 cagatggacc agcctgtgct cgtcaatgta ttcgtgagca ttagtttgat tttcgcgttt 682681 gttgtgctgt atgtgttccc ggtattttct cattttgacg taaaaatcag agaggtgctg 682741 agcatcagct ttttcattgc cttcagtcgt ccggcggtga cgcttttgat ggcagcgggc 682801 gctgtcggtg tgctttgtct cgttctgttt catgtcacgt ttctattgtt tttcagcggg 682861 agtttactca gcctgatctt aacgaagctg tcctttaaag cgtttcggtc aatggatcag 682921 cggcaggaga aagaaaaggc ggcatgaaga aaagagttgc tggctggtac aggcggatga 682981 agattaagga taagctgttt gtgtttctat cgttgattat ggccgtatcc tttctgtttg 683041 tatacagcgg ggtccagtat gcctttcatg tgtatgatga gcagatttac cgcaagtcct 683101 cggaggtgct tcggatgtct tctgaaagga tcgaagacga gctgaagaag atagaggatg 683161 tgtcatatga aatcattaca gacgaacaga ttcagcgcat cctgagcatg caaaatcggg 683221 atgatacgta tgatcaatat caaatgaagc aggagctgtg ggatcagctt gcgggatatg 683281 ccagcgatga aaagtacatc gattccattc atgtgattga tgcccgcggc tcagagtatt 683341 cagccggaag cagttcttca gatcttttgc agcaggagca ggaagaggta tttaagcgag 683401 cgaaagcgaa aagtggaaga aatctttgga tgacgctcgg cgggtcagac cccgtcctga 683461 tttcagcacg gcagatcagg tcctatcacc agctgagtct gaacggcttg ggcatggtac 683521 tgatccaggt caatgtaaaa cagatgattc gtgatgtgcc gaaggattgg ggcgattcag 683581 tcggagacat tatgattgct gaccaaggcg gtaatttggt gtatacggca catgcatcag 683641 cgcatgttcc tgaggcagca aaagagacgt tgaagcaccc cggttatgac ttgataaaaa 683701 agaatggcaa acgttacttt atttcttatc ttcaatcatc ctaccaaaat tggagctact 683761 ataacgttat cccctttgat cagatgttcg caaaaatttc ctttatgaaa acagtgatcg 683821 gcacatgctt tcttctcttt ttctgtgtgg ttttgctttt cggaaggaaa atcgccaaca 683881 gcatcacgga gccgattgaa cagcttgtga ccgcgatgaa atcggtacag cacagcggca 683941 ttgaagcagg tgtgtcgctt tctctgccgg aacatacaca ggatgaggcc ggcatgctga 684001 accgccattt tactgtcatg atgaaacgga ttaatgagct gatggaagaa aatgtggaaa 684061 aacagctcat cattaaagaa accgaattga aagcactgca agcccagatc aatccgcatt 684121 ttttatataa cacgctcgag tccatcaatt ggctggccaa ggcgaatcag caaaagcaaa 684181 tctcaaaaat ggtggaatcg ctcggttttc ttctgcgaaa cagcatacat atgaagaagg 684241 atatcgtgac cattcaggag gaggcggaca ttgtacgtca ctatatgacc attcagcgat 684301 ttcgatttga agagcgcctg aaattcacgt tggatattga cgatgaggtg aagcattgcc 684361 tcattccgaa actgacgctc cagccgcttg cggaaaatgc gattcaatac gcgcttgaac 684421 cctttacaag gccatgcgcc atccggattc aggcgaaaaa ggcgaagggc tgtgtctgta 684481 ttacggtcga agataacggc cctggcatgg atggacggat tcttgaatca acgggtggaa 684541 gaggaatcgg actttggaat attcgcgagc gcatcagcct gacattcgga gagccatacg 684601 gattgcggat tcatagtgag catgaaaagg ggacgaggat tgtgatcaca ataccgtgcc 684661 gaaatgaggt ggtgtgatgt ataaaatact gctggctgat gatgagagga ttatccttga 684721 tggaatggcg ggaatcattg agtgggagtc gcttggcgcc tcattgatcg gaaaagcgca 684781 gaacggacat gaagcatatg aaaagattgt acataagcag ccgcatatcg tcatcacaga 684841 cgtcaaaatg cccggcatgg acgggcttga gctgatcaaa aaggtgtcag ccgtcagccc 684901 gtcggtgcaa tttatcgtcc tgtccgggtt tggagagttt gagtacgcaa aggaagccat 684961 gaaatatggg gtgaagcatt atttgctgaa accctgcaat gaacagcaga ttatcagctc 685021 gctggaggaa atcattgctg agctgaagcg gcaagatgtg cacaaaaaga aaacagccca 685081 tctgaaacac gagctggacc atatccgttc ctttgcagcc gatcaatact tggaaggctt 685141 gatcgccggt gtggcccagc tttctccgcc gccttcactt gccggaaaaa agatccgcct 685201 cttgatctta aaaggggaac aatctattga tgctgcagcc agagaggcac tcggatcggc 685261 actgacagcg gtttgcagca gcggtgaatg gaccgtgctc gccgtagagg agaacgccgc 685321 tgaaaaggtg gcggaggttt ttgcggaccg caagatggcc atcagtcagg cgggagaact 685381 ccggcacgcg gggcagctgt ttcgtgacac agctgaagcg tctggtgacc tgcatgggag 685441 cgcagtgatt tcaaaaatga tcaggcttat tgccgacgag ctcggaaatc cgaatctgtc 685501 cttaaaatgg gcggcgaagg atatgctgtt tatgaatcct gattatctcg ggaagttatt 685561 taagcaggaa acaggcgaga aattttccca atatgttaca cgggtgcgtc ttgagcatgc 685621 gatgaagcag atgaaaataa ggagggacgt gagcgtttca gaaattgctg aagaaatcgg 685681 gtttggcgat aatccgaagt atttcagtct tgtttttaaa aaatataccg gtctgacacc 685741 gtcagaattc agaagaaaac agggaggcgc ttccgcagga tagccatctc tgtttttttg 685801 actttcgcca ctgttttttg agtgtttcgc cctatccgaa cgctttaaaa taaaatgtaa 685861 gcacttacat taaagggggg attggtttga agaagatttg ttacgtgctg ttatcccttg 685921 tctgcgtctt tttgttcagc ggatgttcag cgggtgaaga ggcctcggga aaaaaagaag 685981 atgttacact cagaatcgcg tggtggggcg ggcagccaag gcatgattat acaactaagg 686041 taattgaact atacgagaaa aagaatccgc acgtccatat tgaagcggaa tttgcgaact 686101 gggatgacta ctggaaaaag cttgcgccca tgtctgccgc cggccagctt cctgatgtca 686161 ttcaaatgga taccgcttac ttagcccaat acggaaagaa gaaccagctg gaagatttaa 686221 cgccgtatac aaaggatgga acgattgacg tcagttcaat cgacgagaat atgctgtcgg 686281 gcggaaaaat cgacaataag ctttatggat ttacgctagg tgtcaacgtg ctgtctgtga 686341 ttgccaatga agatttgctg aaaaaagccg gtgtgtctat caatcaggaa aactggacgt 686401 gggaggatta cgagaagctg gcgtatgatc ttcaggaaaa agccggtgtc tacggttcca 686461 acggaatgca tccgcctgat attttcttcc cttattattt gcgcacaaag ggtgagcgct 686521 tttataaaga agacggcact ggcctcgcgt atcaagatga tcagctgttt gtcgattact 686581 ttgaacggca gctgaggcta gtgaaagcga aaacgtcccc aacacctgat gaaagcgcac 686641 agattaaagg gatggaagac gattttatcg tcaaaggcaa atcagcgatt acatggaact 686701 actccaatca atatttgggc tttgcccggc tgacagactc gccgctgtct ctctatctgc 686761 cgccggagca aatgcaggaa aaggcgctga cactgaagcc cagtatgctg ttttccattc 686821 cgaaaagctc tgagcataaa aaagaggcag cgaaatttat taatttcttc gtgaataatg 686881 aggaagcgaa ccagctgatt aaaggcgagc gaggcgttcc agtctccgac aaggtggcgg 686941 atgcgattaa accgaagctg aatgaggaag aaaccaacat cgtggagtat gtagaaaccg 687001 cgtcaaaaaa catcagcaaa gccgatccgc cagagcctgt gggaagcgcg gaggtcatca 687061 agctgctgaa agatacgtca gatcagattc tgtatcagaa ggtatcgccg gaaaaagccg 687121 ccaaaacgtt ccggaaaaag gccaatgaga tattagagag gaataattga cgggaaatgg 687181 ggctgacgca atgaaaaaaa gccggagtat aagaaaagac aatctggcgg gatatgcttt 687241 tatttctccg tttatcatcg ggttcctatg ctttacggtg attccgatgg gggcgtccct 687301 gtttctgtcc ttcacgagct atgacttgtt tacggcgccg aaatggatcg ggctcgacaa 687361 ctttaaggaa atgtttacgg gtgacgaaaa gtattggcag tctctgaagg tgacgtttac 687421 gtatgtgctt gccggggttc cgctccgcct cggcttcgcg ctttttatcg ctgtcatttt 687481 aaacaatgca gcaaaaggaa cggccattta cagaacgctc ttttatctgc cttcgatcat 687541 cggcgggagc gtcgccgtgg cgattatgtg gcgcaatatt tttggcaatg acggggtcat 687601 caatgcgctg ctgttttttg tcgggattga tcaaaaaatt ctttggtacc agaatccgac 687661 aagtgcgctg tggacattga ttctgctgtc cgtctggcag ttcgggtcgt caatgctgat 687721 ttttttggcc gggctgaaaa acattccgtc ttcgtatttg gaagcggcaa gtgtggatgg 687781 ggcaaatcgg gtgcagcgtt tcttcaagat cacgcttccg atccttacac cgattatttt 687841 ctttaaccta gtgatgcaga cgatttctgc ttttatgaca tttacacctg cctatatcat 687901 ttcgaagggc gagggcgggc cgcttgacgg gacacttctc tattcgctct atttgttcca 687961 gcgtgcgttt aactattttc aaatgggcta cgcatcggcg atggcgtggg tcatgcttgt 688021 cattgtcggg ctgattacgc tcatattgtt taaaacatcg tcatattggg ttcattacga 688081 gtcaaaggag gaatgacgga tggagccggt caaccagcct gtcagagaag ccccggtttt 688141 tgagagaaaa aaagccgggc gcgtcagtcc caaacgcata ctgttccatg tttttacggc 688201 aacgctggcg gtgttgctgc tgtacccggt tatttggctg tttgtcagct cgtttaaaga 688261 aagcgccagt atttttacaa cctcacattc tctcattcca gaccctttta ttctcagtaa 688321 ctatgctgaa gggtggaagg gcattgcggg acagccgttt ctgacgttta ttaaaaactc 688381 ggcgattatt gtcgggctgt caacaatcgg tgccgtcatg tcatcggctg tcattgcgta 688441 cggatttgcg cgtataccgt ttaagggaaa aaaattttgg tttgcgtgca tgatggggac 688501 gttaatgctg cctcatgaag tgttgatgat tccgcagtat attatgtttg cgaaattaga 688561 ctggctgaat tcctttaaac caattgtcgt tccgcaattt ttcgggcatg cgttttttat 688621 ctttctgatg atccagttta tccggacgat tcccgaggag ctggatgaag ccgcgcgaat 688681 cgacggatgc ggacgctttg cctgcttttg gcggatcatt ctcccgctga ttgcccccgc 688741 gcttgcgacg tctgcgattt tctccttcta ttggaagtgg gaggagctga ttcagccgct 688801 cttgtatttg aataagccgg agctttaccc tgtttcactt gcgctgaagc tttttctcga 688861 tacagagtcg gcttcgaact ggggcgcgat gtttgccatg tcagccgtct cgttattgcc 688921 tgtgattctt gttttctttt tgtttcagaa atatatcgtt cagggcatca gtacgaccgg 688981 attaaaataa aaaggagtgt tgcagatggc acagcttatc tttgatgaag aaaaggtgac 689041 gtcggttatt gaccggatcg tgaaacggac atttcagatg gattttgcgt gggattggcc 689101 gggcggcgtt gcgttttacg gtgtggcgga ggcctatgaa gcgacggaaa acgaggaata 689161 tatcaatctg ttaaaaacgt gggtggatga acagctggag gatgggctgc cgccgctttc 689221 gatcaacgga gtttccattg ggcatacgct tttgttcctc cacaaggtga caggtgatga 689281 cgtgtatttg gaaacagcgg ccgagatggc ggaatatgtg ctgcataagg cgccgcgctt 689341 tggcgagggt atccttcagc atacggtgaa tgcggcagaa tacgtattcc ctgaacaggc 689401 atgggcggat acgctgatga tggctgggct gtttatgctg agaatcgggc gggtcatgga 689461 gcgtgaggat tattttgaag acggcctgcg ccagtttcac ggacatgagg atgtgcttca 689521 ggaccctgtc acgaatttgt actaccacgc ctgggacaac aaagcgcaaa atcatctgtc 689581 ggggatttat tggggcaggg cgaacggctg ggcggcactc acgatggcaa aggcgctccc 689641 gcttattgag gtgacacatc cttcctttat gatcatcgac ggatcgctca gagaccagct 689701 gagcgcgctt gtccggcttc aggatgaatc agggctgtgg catacaattt tggatgatcc 689761 ggattcttat ctggaggttt cggcatcagc gggtattgct tctgctctga tgtcgagcgg 689821 aaagctgtat acaaaatatg tgcagaaatc gcttgccgcc attttggatg cagtggaaga 689881 ggacggacgg gtcagcaggg tatcggccgg gacagccgtc atgaaaaatg ccgaaggata 689941 caaacaggtg ccttacaaac gaatacaagg atgggggcag ggacttgcgc tgacgtttct 690001 tgctgatgtt ttgaaaacga aaaaacgctt gtatcagtaa agatagcggc ggggggagag 690061 ggatgaaaaa acagcctcaa cagaaggaac gggtttctcg ctggaaggga acgtatttca 690121 aaagaaactt tgtcttcatt ttgctgattg cctgtattcc cggattgctg actggcggcg 690181 caatctactt tctttcgatc gacaaggtgg agaaagagct gcagagatcg catgaaacac 690241 aggtggcgcg tgaggtcagc cgaatggatg agaagctggg agtgcttgaa ctggcactca 690301 cccagatggc ctacgattct tcactgatga acggattggc cgagagggat ttggagaaag 690361 actttacgtt ctcctatcaa ttaacgaaaa agctgtttct tttgcgggat cagcagccgc 690421 tgatcgagca ggcttccatc tttctgaaca gcccccggcc acttgtgctg agccctgaat 690481 acagcgcttt gacagaacag gaggcgcttc gcaagtatcg ctcgctgctt gcctcagacc 690541 acagcattta ttggaaacgg tcgggaaacc aagcgatgct gatccagctc attccgggcg 690601 cggcggagaa accgttcggc gcgatcatgc tggcggttga tccgaaagaa atggaatcaa 690661 tcctgcaaag cttgtccccc tatcctgatg gcagtgcgtt gcttttagat caaaatcgag 690721 aggtgctgtt tcatgagggg gaaaaagatt ttgaaaagac tttacttcat gagataaaaa 690781 aacagcctgc tgagaacggc cattttcaga tggaatggaa aggcaaggtg tattctgtct 690841 cctttggaga aatgaaccgg atgcatcagc aatggacctt tgtgtcagcg gcgcctcttt 690901 cagctattac agcgccgatg gtgtttttat caaaagtgat catcgtgatg ctggtcattt 690961 gcatcggttt ggcggtgtgc atgacatggt atgcatcaaa aaaaatctat cgtcccatcc 691021 agcatttgct tggcttgttt accggaggag agaagaaaac atggcaggcg tccgggcagg 691081 atgaattcaa atggattgaa aagagatggc aggatctatc ccttgaaagc cggaagctcc 691141 aacagcagct cctgcggcag acgccccata tgaaaaagag ttttttgcag catctcttac 691201 agagcgattt ttactatgac aacgaggaaa gcctcagatt tcggatggag gaggctggct 691261 ggaacatcgg cggaaacgtg tttcatgtgc ttgatctaca ggtgacaggg ctccgctgtg 691321 aaaaaagcat cttccgtgaa ggtgatgaac agcttgccgt gtttacactg actaatatcg 691381 ctgaggaatt ggcggctaaa cgcgtttttc agctctccat acttgatatc ggccggcttt 691441 ctgtcaccgt tcttgtgatg aaaacaaaca gctctgatct gaaggcgtat ataacggagc 691501 tggcacgcca atttggagat gtaaccggac tatgcctgac ctcgacattg agcagcaaga 691561 cggagcgtgt cacggaaatt ccttctttat ttcaggatgt gaaatgcggc aaatcccgca 691621 ggaagtttgc taaccgggat caggtcattg atttgcaggc cgacttccct cgggatgagc 691681 agttcgctcc ttattaccct tttgagctgg aaaaacaaat tgttcagacc atccggctgg 691741 aaagaaaaca ggaagccaag gaactgatag atggatgtat gaaggaactg tcggaaaaag 691801 cggccataga caggcatgtg cattccgccc tgattcagct gttttcccgc attcaggagg 691861 atattttgca ttccgggctc aatcccagcg aactgtttca gcaccggaat ccgtttcttg 691921 atatttcaga attgcgcgaa cctaacgaag cggcggcctg gctgatggat gtagtggtga 691981 cgccttacct ttccaagctt gagggcagaa aaaacagaca gcaaaagcag ctggcagaac 692041 gtgtgattgc gatgattcac gaacagtata tggcggacat ttcattggaa agctgtgccg 692101 atgcgcttgg catgaattcc tatacgttaa gcaaggcatt taagcaagtg accggcatta 692161 attttatcga ttatgtgacc cagatcagaa tcgaaaaggc gaaagaactg ctggtcaata 692221 cgaataaaaa aattcatgat gtgtctgaag aagtcggcta tcgccacaat tatttcaatc 692281 ggatttttaa aaaacaggtc ggcatgccgc cgggtgtctt caggcaaatg tatcaggaaa 692341 cgccgtgaaa ggagagaaca tgtgatgaag aaaccgattc aagtattttt agcgggggat 692401 tccactgtga gtgactgccc gcctcatgaa gcgccgatgg cggggtgggg gcaggtattc 692461 gggcaattgt tttctgaagg tgtgctggtc cgcaatcatg ccaaaggagg agcgagcacc 692521 aattcttttg tggaggaagg aaggcttcaa gcaattgccg agcacatcac acaaggcgat 692581 tatttgttga ttcaattcgg ccacaatgac caaaaaccgc gggggacgaa gccgtactcc 692641 acatttcagc agtttcttac cttgtttgca gatacggcac gcgaaaaggg cgcgcatcct 692701 gtgttcgtca catcggtgca gcgccgccgc tttgatgaaa acggacggat cgagcatacg 692761 ctcggtgagt atcccgatgc gatgaaagca ctggcgaagg agctcgatgt acctgtgatt 692821 gatctgcttg cgaaaacaaa ggtgctgtat gaagcatacg ggccggagga gtcgaagcga 692881 ttgttcgttt ggtttcagcc gaatgaacat ccgaattacc cggacggcat tgaggacaat 692941 acgcattttt cggaaaaagg tgcaatggag gttgcgaagc ttgtggcaga aggcattgaa 693001 gagctcggac ttccgcttaa ggaccacctt gtgagccggg agggaaaaga acatgtataa 693061 ggaaggcgct tgcttgtacc gcaatccgct ccggtctaaa agcgatgtga aggattggcg 693121 gatggaggga ggcggacaga tctcatttga cgatcacagc ttgcacctgt cacatgtcca 693181 ggatgaagcg cactttgtct tttggtgtcc ggaaaccttt ccagacggca tcattgtgac 693241 atgggacttc tctccgatcg agcagcctgg actgtgtatg ctgttttttg ccgctgcggg 693301 tattcgcggc gaggatttgt ttgacccaag tctcaggaaa agaacaggaa cataccctga 693361 gtatcattca ggagatatca atgccctcca cctgtcgtat ttccgcagaa aatacgcgga 693421 ggaaagagcg ttccgcacct gcaatttaag aaaaagccgc ggtttccatc tcgccgcaat 693481 gggggccgat ccgctgcctt ctccagacga cgctgattct ccgtatcgta tgaagctgat 693541 caaagacaaa ggctatgtgc acttttcaat caatggtctg cccattcttg agtggatgga 693601 cgacggcagc acatatgggc ctgtgttaac aaaaggaaaa atcgggttcc ggcagatggc 693661 ccccatgaaa gccgtttaca gggattttgc cgtgcatcaa gcggtgagaa gatgaagacg 693721 actgtaacgg atgcgcttta tgcaggctgc gaagcggtgg tgaaaatagc atggctcaac 693781 gggctgtggc tgttgtttac acttttgggc ggcgttcttt tcggatgggc gccgagcaca 693841 gctgcgatgt gtgccgttat aaggaaatgg ctgatggggc aaaaggatgt cccgatattt 693901 tcgttatttc tcgataccta taaaaaagag tttctcaagg ttaatgcgat cggattggcg 693961 ttttcggctc ttttgctcat attgtctgcc aactatcatt atttttctgc cagtacgaat 694021 tggctgtcct ttgccgtaac aagctgcacg ctgcttgcag ggcttttgta tatcatcgcg 694081 ctgatgtatg tgtttcccct ttatgtgcat taccagctcc cgcttcgcaa atatattccg 694141 caggcactgc tgtttggcgc catgagaccg ctgacaactg gctgtatgct gatcgggtgc 694201 ggatttgtcc tttatttgct gtatacgctt cctggcctga tcccatttta cggcccgtgt 694261 ttatttgggc ttgtgttgat gttttttgct cttaggggat ttcaaaagac ggaggcccag 694321 caccatcaag ccgggtaaca aaaaaatgac aaataagcaa aaaagtgcag tgtccgaaat 694381 aggcagatgc aaaaaagtga aattgaagac agctcacaaa gcgcataaaa tccaatttaa 694441 gtaagcgctt acagataaat gagaaggagc tgtctgatga ttagacgaag gaaacgcatg 694501 tttaccgctg ttacgttgct ggtcttgttg gtgatgggaa cctctgtatg tcctgtgaaa 694561 gctgaagggg cagcgcggca gatggaagcg ctgaaccggg ggcttgtagc ggtcaagacg 694621 gacgggggca tttttgtcag ctggcggttt cttggaaccg aaaacgcatc tgttttgttc 694681 aatgtgtaca gagacgggca aaaactgaat gctgcgcctg tcaaaacaac gaactatgtg 694741 gataaaaacg gttcggcggg ctcaacgtat acggttcggg ctgttgtaaa cggtaccgaa 694801 cagccggctt ctgaaaaagc ctccgtatgg gcgcagccgt atcattccgt cccgctggat 694861 aaaccggctg gcggcacgac gccaaagggt gaatcttaca cgtacagcgc taatgacgca 694921 agtgttggcg atgtggatgg tgacgggcaa tacgagctga tcctgaaatg ggacccgtcc 694981 aactcaaaag acaattcaca ggatggctat acgggtgacg tgctgattga cgcgtataaa 695041 ctggacggca caaagttatg gcggatcaat ctcggcaaaa acatcagagc gggcgcgcac 695101 tacacccagt ttatggtgta tgaccttgat ggtgacggaa aagcagaagt ggcaatgaaa 695161 acggcagacg ggacaaaaga cggcacgggc aaagtaattg gaaatgccaa tgcagattac 695221 agaaatgaac aggggcgtgt gctttcaggc cctgaatatc tcactgtgtt tcaaggttca 695281 accgggaaag agcttgtcac cgcaaatttt gaaccggcgc gcggcaatgt gtcggattgg 695341 ggagacagct acggcaaccg tgttgaccgt tttctcgccg gcattgccta ccttgatgga 695401 cagcggccga gcctgatcat gaccagaggg tattacgcta aaaccatgct agttgcctat 695461 aacttcaggg acggaaagct gtcaaagctt tggacgctgg actcctcaaa gtcaggaaat 695521 gaagcgtttg ccggacaggg gaatcacaac ctgagcatcg cggacgttga cggggatgga 695581 aaagatgaga ttattttcgg ctcaatggct gttgatcatg acgggaaagg catgtactcg 695641 accggcttag gccatgggga tgccctccat acaggagatc ttgatccggg ccggccgggg 695701 cttgaggtgt ttcaagttca tgaggacaaa aatgcaaaat acggcttatc tttccgggat 695761 gctgcaactg gaaaaatcct ttggggcgtt tatgccggca aggatgtagg ccggggaatg 695821 gctgctgata ttgacccgcg ttatccggga caggaggtgt gggcaaacgg ttctctctac 695881 tcagcgaaag gggtcaaaat cggaagcggg gttccgtcct cgaccaactt cggcatctgg 695941 tgggacggcg atctgctccg ggaacagctg gacagcaacc gaattgataa gtgggattat 696001 caaaacggcg tatcgaaaaa tatgctgact gcatcaggcg cagcggctaa caacggcaca 696061 aaagcaacac caacgcttca ggctgatctg ctcggtgact ggcgcgagga agtggtgtgg 696121 agaacggagg acagcagtgc tctgcgcatt tacacgacga ccattccgac tgagcacagg 696181 ctgtatacgc tgatgcacga tccggtgtac cggcttggca tcgcctggca aaatatcgcc 696241 tataaccagc cgccgcacac aagcttcttt ttaggagacg gcatggcgga acagccaaaa 696301 ccaaatatgt atacgcctta actgaaaggg ggaaggaacg ggctgcgcgc agcccgttcc 696361 catcaaatga aaccaaaaaa gaggcaaatg gaatacctga ccagaggttt gattgcggta 696421 cagacagaac agggcgtgtt tgtcagctgg cgttttctcg gcacggatca tgagacgacg 696481 gcttttcacc tttatcggga tggaaagcgg atcacccgcg atccaatcgc tgaaagcact 696541 aattttctcg atcaaaacgg aacggctgac tctgtttatc aagtggcggc tgtcaataaa 696601 ggacgggaag aaaagctttc caagaaagct cgtgtttggc aggaaaatgt cctggaggtt 696661 cctcttgcca aaccggaagg cggtgtgacg ccggacggaa agccgtacac ttacagcgcc 696721 aatgatgcca gtgtcgggga tatagacggg gatggagaat atgaaatgat cctgaagtgg 696781 gacccgtcca attcaaaaga caacgctcat gacggttata ccggggaggt gctcatagat 696841 gcctataaac tggacggcac ctttttgtgg cgcatcaacc tcggcagaaa catcagagcg 696901 ggtgctcatt acacgcaatt tatggtgtat gaccttgacg gtgacggaaa agcagaaatc 696961 gccatgaaaa cagctgacgg cacaacagac gggaaaggac atatcatcgg tgatgagcag 697021 gccgatttta gaaacgaaca gggcagaatt ttgtccggtc cggaatattt gaccgtgttt 697081 aaaggagaaa ccggtgaggc gctcacgacc gtggaatatg aaccgccccg cggcaagctg 697141 gaggattggg gagacggcta tggaaaccgg atggaccgtt ttctcgccgg gaccgcttat 697201 ttggatgggg agcggccgag ccttgttatg gcgcgcggct actatacgag aaccgtgctc 697261 gtggcatacg atttcagaaa cggaaggctc aaaaaacgat gggtatttga ctccaaccag 697321 ccgggacatg aagcatacgc aggacagggg aaccacagct tgagcgtggc ggacgtcgac 697381 ggagacggaa aggatgaaat catatacggc gcaatggctg tcgatcatga cggaaccggc 697441 ctgtactcaa cgggcctcgg gcacggagac gcgatgcatg taggggatct ggacccgtca 697501 cgaaaagggc ttgaagtgtt ccaggtgcat gaggacgcca cgaagccgta cggactgtcg 697561 ctgcgagatg ccggaaccgg tgagatatta tggggcgtcc atgctggaac tgacgttggc 697621 cggggcatgg cggctcatat tgatccaagc tacaaaggat cgctcgtctg gggaattgat 697681 ccgccgggca atgatggcat gtcgtacggg cttttcacga gcaaaggcga aaaaatcagc 697741 gacaaagcgc cctcttcagc caatttcgcc atctggtggg acggtgattt ggtcagagaa 697801 ctgcttgatc atgactggga cggaacgatc ggcaggccaa agattgaaaa atgggatgct 697861 gaaaacggct gtctgaagac gatatttcag ccggccggcg tgttgtccaa caacggcacg 697921 aaaggaaacc cggttcttca ggccaacctg ttcggagact ggcgggaaga agtgatatgg 697981 agaacggaag acagcagcgc gctccgtatc tatacaacaa cacatctcac ccgccactgc 698041 ttttacacgc tgatgcatga tccggtttac aggctcggca tcgcctggca gaataccgcc 698101 tacaaccagc cgccgcacac gagcttttac ctcggaacgg gaatgaaaaa accgccgaag 698161 cccgccctgt acatagcggg aagcaaagcg gaggcgccgc tgtaggagga ctaagggata 698221 agacgcaaag gctgaacgct acgccaagat gattagagaa ctggcaggac gaaccaatgc 698281 tcaagcgctg tacgcaccgg ttttttcaag ggaagagcta tccgtgatgg aagctgtata 698341 aaaaacgagg aggaatgaaa aaatggcaaa tcatatttat cttgccggcg attcgactgt 698401 tcaaacgtat ggagacagca caaatcaagg gggctggggg cagtttctcg gctcgcatct 698461 gccggagcat attcaagtga tcaacagagc gatcggggga agaagctcga aaacatttgt 698521 ggaagagggc aggcttcagg caatcctcga tgtgattgag ccggatgatt ggctgttcgt 698581 gcagatgggc cataatgacg cgtcaaaaaa taagccggag cgctacaccg agccctatac 698641 tacttataaa caatatttaa agcagtatat cgcaggcgcg cgggaaaaag gcgcccatcc 698701 gcttctcatt acccccgtag cccgctttca ttacgaaaac ggcgtgtttt tgaacgattt 698761 tcctgattac tgcattgcca tgaagcagac ggccgctgag gagaatgtcc agctcattga 698821 tctgatggag aaaagtctcg ctttctttac tgagaagggc gaggaaaaag tgtacaccta 698881 ttttatgatt tcagaaggga ttaacgatta cacgcatttt acaaaaaaag gcgcaaatga 698941 aatggcgaaa cttgtggcaa aaggcataaa ggagctcggc ctgccattga cagaatcgat 699001 catcaaagaa aggtgaaaat gtgatgagaa aactgtatca tggcgcttgc tattatccgg 699061 aattatggga tgaagagacg attcagcagg acattgacat catgcgtgaa gttggcgtaa 699121 atgttgtgcg gatcggcgaa tttgcctggt cagtcatgga acctgaagaa ggaaaaattg 699181 acgtcggttt tttcaaagaa atcatcgccc ggctgtatga tagcgggatc gaaacgatta 699241 tgtgcacgcc gacgcctacc ccgccgattt ggttctcaca tggccggccc gaacgcatgc 699301 atgccaatga aaaaagagag atcatggggc atggctcccg tcagcatgcc tgtacgaaca 699361 acccgtattt ccgaaaaaaa gccgccatca tcaccacagc catcgccaag gagcttggcc 699421 ggctcccggg gctgatcgga tggcagctag acaatgagtt taaatgccat gttgcagaat 699481 gcatgtgtga gacatgcttg cgcctatggc atgactggct caaaaatcgc tacggggtaa 699541 ttgagcgctt gaatgaagct tggggaaccg atgtgtggag cgagacctat cagacgtttg 699601 agcaagtccc gcagccggga ccggccccgt ttctgcatca tgcctctcta cgcactatgt 699661 atcagctgtt ttcgatggag atgatcgctt cgtttgcgga tgaacaggcc aaaatcatcc 699721 gctgctattc agatgcgccg atcacgcata acggatcagt catgttcagc gtggacaatg 699781 agcgaatgtt tcagaatctc gattttgcct cctatgacac gtacgcttcg caggaaaacg 699841 cctctgcctt tttattgaac tgtgatttat ggagaaatct gaaacaaggg cgcccgtttt 699901 ggattttgga aacgagtccg tcgtatgccg cctcgcttga aagctccgct tacccgcacg 699961 cagacgggta tttgcaggcc gaagccgtat cgtcctacgc cttagggagc caggggtttt 700021 gctactggct atggcgacag cagcgttcag gcagcgagat ttcccacggt tcggttctca 700081 gtgcctgggg cgaacccacc atcggctatc aaaatgtgct ggcggttgag cgggcaagaa 700141 aggaaatcga gcctattatt ctatcgactg aacccgttca agccgaggcg gcgatgactt 700201 actctgacag agcaaaagca tttattaaaa ctgagcctca ccggggactc cggcatcgtt 700261 cgcttgtgac gcatttttat gaacgtattc tcaacacggg gattcaccgt gaccttattc 700321 cggaaggcgc tccactggac ggctatcgct tgctgtttac gccatttgtg ccgtatttgt 700381 cttctgaatt tatcaaaaaa gcttcggcat tcgctgaagc gggcggcatc tggatcaccg 700441 ggccgctgac aggaggacgc acatgcgagc ataccattca taccgattgc ggacttggcg 700501 aacttgagaa aacgtcaggg atcaaaacac tttttacctt tccgatgaat gagaacgtga 700561 atacaggaaa agcgtttggc atcacggcgc cgctcggact gtggagcgcg gtgtttgaca 700621 cagagagcgg aaacaccctt ggcacggttg aagcaggacc gggggcgggc catgcttttc 700681 tgacggaacg gaattacggc gaggggaaaa ttgtcatgct gggctcgctt ccatccggga 700741 aagaagggga tgcgatgctg gaagcgctcg tcaggcatta tgcggaggaa gctgttattt 700801 ccagccggtc ggatgtgaca cccggcacga tcgttgcccc gcgtataggc gaaaacggcc 700861 ttgtgtggat cgttgtgaat atggatggaa aaggcgggag cgtgacattg ccggaatcgg 700921 gaacggattt gttgacgcac cgcttggaaa aggcggggag actggcggtc ggaccgcatg 700981 aataccgtgt gattcaattt gacaatcaca gctgattctt tgtatcgaat cagctttttt 701041 ctatggaggg agagacagat gaaaaagatc aaatggttat caggacagcc aaaggtgaca 701101 agcggcgtga cgtggggcat gccatggaaa aaaggagaat taaaaaaagg agaccgtctg 701161 gcgcttatga atgaaaacgc ggaaacgcga tatgtgcaaa gcgaaccgtc ggcctattgg 701221 ccggacggga gcatcaagtg gacgaagcac gcggcggtgt ttggcggtca ggaaaaccaa 701281 agctttacag tgcacaaaag agaagtgccg cagccaactg aatcgctcag cattcttgag 701341 acagagcatg atatccaagt ggatacagga gcactcgttt gtaccattca taaaacagga 701401 tctgatttca ttcaatcatt gcagatcaat ggaaagccga tcgccgcagg cgggaggctc 701461 gttgcgataa gagaaacgag aaaagagtca gcggcgaaaa tggttctttt gcatgaaagg 701521 tctgtcagct ttatcaaacg ggcggcgatt gagcagagtg gtcctgtcaa agcagtagtc 701581 aaaatcgagg gagtgcatgt gcttcataaa acgtatgagg aatggctgcc gtttgtcatc 701641 cgattaacgt tttatgccgg gctgtctgag atcggccttg tgcacacgca gctgattgac 701701 aggagcggta aactagaatt cgttaagggg ctcggcatcg aattcgacct ttttttggag 701761 ggagagccgt acaaccgcca tttccgcttt gcgggagaga aagggatgta taaagaaccc 701821 gcccagctgt ttggcacacg taaattcaat gaacgatatc cgctttatga aaaacaaatc 701881 aatggcgaaa tgctgtctcc agatgaagag cataaggaat ggtttgcaca tggcacacag 701941 aatgcggttt gggacgatgt caagatcgtg caagattcca gcgatcatta cagcctgtca 702001 aaacggaccg gaaaagatta tgcgtgggtt ggaatgctgc atggcagccg ggcgaagggg 702061 ctctgctatg cgggcggaaa aaatggcggt gtggctctcg gcctgcggta tttctttgag 702121 aaatatcctt cagcactgga aatcacaggt cttgccggca gccgccccaa aatgactatc 702181 tggctttggc ctccggacgg cgaagcgatg gatttgcggc attatacagg aaacactcac 702241 gtggccagcg cgtatgaagg ctttgatgaa atgcgctctg atccgacagg cattgcgaac 702301 acaaatgaaa taagcctggc gtgcttttcg cacatgccgt ctgacgaagt cctcaatgcg 702361 ctggctgaca aatggcaggc gcccccgctc attgtatgcg agccggacgt ctattacgaa 702421 tcaaaagcac tcggggtatg gagcatcatt gacacatccc atccgctcaa aaaagagctg 702481 gaagaacagc ttgatgcggc ctttctgttt tataaaaagg aagtagagca acgcagatgg 702541 tacggttttt ggcattatgg cgatgtcatg catacgtatg acccgatccg gcatatgtgg 702601 cggtacgatc tcggcggata cgcatggcaa aacaatgagc tcgttccgac cctatggctg 702661 tggcaggcgt ttttccgctc aggcagagag gatatcttcc gaatggcaga agccatgacc 702721 cgccatacga gtgaaacgga cagctttcac ctcggtgaat atgccgggct tggctcacgg 702781 cataatgttg tgcactgggg atgcggctgc aaggaagcga gaatcagcat ggccgggctt 702841 cataaattct attattatct gacgggtgat gaccggacgg gagatctttt gacagaagtg 702901 aaggatgccg attatgccct tgtcaaaacc gatccgatgc gcgcttttta cgagaaaggc 702961 aagcacccga ctcacgccag aacgggaccg gactgggcgg cgttttgctc gaactggctg 703021 gcggaatggg agcggaccga aaattcggaa tatctcaaaa aaatcgaaac gggaatcaac 703081 tgtctgaagc ggctgccgct ccgcttatta tctggcccga catttgaata tgatccggcg 703141 acctcgatgc ttcatcatat gggagacggc attgcgggcg gatatcatat gatcattgcc 703201 ttcggcgcgc cgcaagtgtg gatggagctg gctgagcttc ttgatgactg ggaatgggag 703261 gatatgctga gtgaattcgg cgaattttac acactcagtg atgaggaaaa acgaaaaaaa 703321 agcggaggcg ctcttcatga cgggcatttt cactggccga tgttcgccgc cggtatgaca 703381 gcctacgccg caagaaaaaa gcaagatcct catctcgccg ccaaagcgtg gaatcttttg 703441 ctagaagata agctcagcca tacgccgctt ccgatcaaac cggagcgcat cgagacatgg 703501 acgcagctag aggagcttcc atgggtgaca acgaacactg tctctcaatg gtgtttaaat 703561 gtcatagcgg cgctggaact gatcggagat tcccttccgg caaaaaaaga aacatcgggc 703621 aaaaaaggat aacagccgga atttcatagg agaaatggtg caaaaaatga agattgcaag 703681 aatttatgta agcgctttat attgagaggg gcaaagggga aatgcaaatt gaaaaaaggg 703741 ggacttacgc aacatgaaaa taagaatgcg aaaaaaatgg atggccttgc cgcttgctgc 703801 catgatgatc gccggatgca gccattcgga aacatccaat tcagcaagcg gttcgaaaga 703861 tacgatcaaa attatggcgc cgctcttatc gccggaaagc ccaagtgata agagcccttc 703921 attaaaagcg ctcgaaaaat acacaggcaa agagattaag gtcacatggg tgcctgattc 703981 atcctacaac gacaaattca acatcgtcat ggcttcagga gagatgcctc acgcgattgt 704041 cattaaagat aagtcagccg gctttatcaa atctgtcaaa gcaggggcgt tttgggagct 704101 gtctccttat ttaaaagact acaagaattt aagccaggca gatgaaaaga ttttgaagaa 704161 cagctcggtg aacggcgagg tgtacggaat ctacagaacg agggatctga tcagggcgtg 704221 tatgatcatc agaaccgact ggctgaaaaa tgtcggtctg gatatgccgg aaacgcttga 704281 tgatttctat gaagtgctga aagcctttaa ggaaaaagat cctgacggaa acggcaagga 704341 tgatacgtac ggcatggtcg tgccgaaatg gatgggactc ggcaacggaa gcccatggga 704401 tgttctgcaa atctggttcg gcgctccgaa ccgctacggt gttgaaaacg gaaagctgat 704461 tccagatttt acaacgaagg aatacatgga tgcgctcacg ttttttaaaa agctctatga 704521 tgagggcttg atcaataagg actttgctgt catggattct gcgaagtgga atgatccggt 704581 tgtaaaagga aaagcgggtg tcatcgttga tacaggctca agagcgtctc aaatccaaag 704641 cgcgatggag gaggcggatg agtcgaacaa ggatatcatt gatatcgtcg gctcgcttga 704701 gggaccgaat ggcaagcgca ccttcccgac atctggttat tcaggcatga tcacgatacc 704761 aaaatcaagc gtcaaaaccg aaaaagagct gaaagaggtg ctgtccttcc tcgataagat 704821 gaatgataag gaagcgcaga ttctcacgaa caacggagtg aagggccgca attacgagct 704881 caaggacggc gtattcacct cacttgaaaa aaacaataaa tctctcctgt atgagcatga 704941 aggcttggca cagttcagca tgtcgattcc gaaaagcgag tattacatcg aagaccagaa 705001 aaccaagctc ttccagcatc gcaaggacat cataaccgaa ggagaaaaaa tagccgtctt 705061 taaccctgct gagtcgcttg tatctgatgt ctatacccaa aaaggagccc agcttgacaa 705121 catcatcctc gacgcgagaa cacaatttat cattggagaa attgatgaaa aagggttcga 705181 tgatgcggtg gagctttgga aaaaaagcgg cggcaatgaa ctgatgaagg acttgaacaa 705241 attgtaccaa tcgtcaaaat aaaccgatgc gcctgccttt cggcgggcgc cccggtatca 705301 cgaaaggaga acagatatgg aaacagtgcc gaagaagaga gatgcacctg ttctcaccgc 705361 tggaaaaggc atcagctgga tggctgcgct caaacgggac aaatggcttt atcttcttct 705421 tattcccggt ctgctttatt tcttgatttt caaatacttg ccgatgtggg gtgtgctgat 705481 cgcttttaaa gactattcgc catatctcgg cttctggaaa agcgaatggg tcggctttga 705541 ttatttcaaa gactttttta tgaatccgga ttttttccgg ctgctgcgca acaccctcat 705601 gctggcgagt ctggatcttt tgtttgcctt tcccgcgcct ctcattttgg ctctgctttt 705661 gaatgaggta agaaaggccg tgtataaaag atgtatccaa acctttattt acgtacccca 705721 ttttgtatca tggacaattg tggtcagcat caccttcgtt ttctttactg tcgatacagg 705781 tgtgatcaac aaattgatta tgagcctgac aggtgagcag atttctttct tgtcggatgc 705841 agactggttc cggccaatga ttgtgatgca aagcatttgg aaggagacag gctggggaac 705901 gattctattt ttggcagcgc ttgctacggt tgatcaagag cagtatgaag cggccatcat 705961 ggacggagcg gggcggttca ggagaatgtg gcatattacg ctgccggcga ttagaagcac 706021 cattatcgtt ttgttgattt taagaatcgg cagctttttg aatcttggct ttgaacaggt 706081 gtatttgatg acgaactcac tcaaccgcag tgtggctgac atcttcgaca cgtatgtgta 706141 catgatgggg attacccaag gggcgtatag ctacagcacg gcggtcggtt tgtttaaatc 706201 agttgtcggg attatcttga tttttggcgc caattacatt gcgaaaaagt ttgatcagga 706261 aggattgttt tagaggaggg agaggtatgg ctgaaattca cacgatgcac aacaccaaag 706321 ccggacgggt gtttgacgtc tgcaacattc tgtttctcgg cggtgtcggc gcgattacca 706381 ttttgccgtt tttatatatt atcgccggtt cctttgcgac agaagcggaa ctcgcccagc 706441 ggagcttctt tattttcccg aaaaccttta cacttgatgc ttacaagtat gtgttttcga 706501 caccgacgtt ccttcgaagc atgggcgtgt ccatcttcat cacggtggtt gggacggctg 706561 tacagctgtt ttttaccttc acgatggcgt atccgctggc gaaacggcat gtgaagggac 706621 ggaatctgct gttgaatctg gtgattttct ccatgctgtt ttcaggcggc atgattccga 706681 cgtaccttgt cgtaaaatca cttggccttt tggatacgta ttgggcattg attctgccga 706741 tggcgattaa tccgttcaac cttattatta tcaaaaactt ctttcagcag ctgccgcgcg 706801 agctggagga atcagcaaaa attgacggct gttccgaaat cggcgtcttc tggcggatcg 706861 ccctgcctct gtcaaagcca gttattgcga cctttgcgct gttttatgcg gtcgggattt 706921 ggaatgattt cttccacgct ctcttatata tcaatgacag tgcaaaatgg ccgctgcaaa 706981 tggtgcttcg ccaagtcaca attttatcgg atttaacggc gaccaatggt gatacgatgc 707041 aaaatgcagt tccgccggag cagggaatta aactcgctgt cattgtcatt gcgacgctgc 707101 cgattttggc ggtctatcca tttttacaaa aacactttgc aaaaggaatg ctgatcggtt 707161 cggtgaaagg ctgagaaagg gagtgtttca tatcagtaca ttagatcaga ttaagattgc 707221 ctatatcggc ggggggtccc aaggctgggc cagaagcctg atgagtgatt tgtcgattga 707281 tgaacggatg tcaggcacgg tggcgctcta tgatcttgat tttgaagccg ctcagaaaaa 707341 tgaagtgatc ggcaatcaca gcgggaacgg cagatggaga tatgaggctg tttctacttt 707401 gaaaaaggcg ttatcagccg cggatatcgt cattatttcc attttgccgg gatcactgga 707461 tgatatggaa gtcgatgtgc acttgcctga gcgctgcggt atttatcagt ctgtaggtga 707521 tactgtcggg cctggaggga tcatcagggg cttgcgtgct gtgccgatat ttgcggaaat 707581 tgcccgggca ataagagact acgcacctga atcatgggtc attaattata caaacccgat 707641 gtctgtctgt acaagagtgc tgtataaagt gtttcccggc atcaaagcga ttggctgctg 707701 ccacgaggta ttcgggacgc aaaagctatt ggcggaaatg gtcacggaaa ggctggggat 707761 tgaggtgccg cggcgtgagg atatccgcgt taatgtgctc ggcattaacc attttacatg 707821 gatcacaaaa gcctcttacc gccatattga cctgttgcct atattccgtg aattcagcgc 707881 gcactatggg gaatcaggat atgagctgga gggggaatgc tggagggaca gcgtcttttg 707941 ttcggcacac cgtgttgcgt ttgatttatt tgaaacgtat ggcgccatcc ctgctgcggg 708001 tgacaggcat ctggcagagt ttcttcccgg cccatacctc aaacagcctg aagtatggaa 708061 atttcatctc acacctatat cattcagaaa acaagacaga gctgagaaac gacaagaaac 708121 agaacggttg atcgtgcaac aacggggcgt tgctgagaaa gcttcgggag aagaaggcgt 708181 gaacatcata gcggctcttc tcggattggg tgaactcgtc acaaatgtaa atatgccgaa 708241 tcaaggccag gtcttaaacc ttcctataca agccattgtc gaaacaaacg cattcatcac 708301 aaggaaccgt gtccagccga ttttgtccgg agcgcttccg aaaggtgtgg aaatgctggc 708361 ggctaggcat atatccaatc aggaggcagt ggcggacgca ggtttaacaa aggatactgg 708421 cctcgcgttt caagccttcc tcaatgaccc gcttgtccag attgaccgca gtgatgcaga 708481 gcagcttttc aatgacatgc tccaatgcat catgcaaagc tgagcttgcc gattagctct 708541 ttccggttta gaaaggaaag cattgaccat actgatagta taatcaagaa gtaggtgcta 708601 tcaatatggg aaattattta agtgttgcgg tagaactggt ctgcggttta ggcattttat 708661 ttatcatctt aaagcttctc gggaaaaccc aattttctca aattacgccg tttgacttta 708721 tttctgcttt aattttaggt gaattggtcg gaaatgccgt ctacgatcat gaaatcaaaa 708781 tcaaagaaat tatttttgct tcgctattgt ggggcgtgct gatttatatt attgaattta 708841 tcacgcaaaa aatgaaatca tcgcgaaagt tcttggaggg cgagccgaat atcgtcatcc 708901 gcaaagggga gcttcaatat aaagtaatga agaaaaataa gatagacatt aaccagctgc 708961 aaagcctatt gaggcaagct gggagctttt cgatccaaga agtagaatat gcgattcttg 709021 aaacaaacgg gatggtcagc gtgcttccaa aatcagactt tgacaaaccg acaaataagg 709081 atttgcagat tccttcgaag tccgtttctc tgccgatcac gttaatcata gatggagaga 709141 ttgtgcggga taatttgaag gaagcaggtg tggatgaaca gtggctgaaa caagaattga 709201 aaaagaagaa cattgataag acagaggacg tgttatttgc agaatggcat aaaaataagc 709261 cgctgtatac tgtaacgtac gaacaaagca gatcaacatg actcttagaa aaaagcttgc 709321 agcaaggcgc aagcttttta ttgattgtat gtcccttgtt tgacagcacg tacatggtac 709381 atgctcactt cagtgctgat cagatagtca ggctttggtt tgcctttgtt tgctttatgg 709441 ccggcgatat gcgcatcgct tttttcccat tgcttccagt gatcctctga ttcccagcga 709501 atcatgacaa caacttcttc atcaccgcgg cgcacatttt tctcaagcac tgtcacatca 709561 attaaacctt cttgtttttc aatgattcct tcagcgctga aacgttctat gactttatct 709621 gcaaagcctt ctttaaccgt catttttctc aactgtacaa acatttgtct cactccaatc 709681 attctcacat atgaataatt gtaaatgaaa ttcattctca atgtcaaaga aagcgcaggg 709741 cggaatcgaa ccgccgtgcg caacagttta ttcttttaat aaaaacacat ttccgtcttc 709801 gtccttaaat tgaacgaagg tgccccactc catttgattg ggctcaccga gaaattctac 709861 accgtttgtc ttcattttct cgtatgtacc aaagatgtct tcgcattcaa acacaataga 709921 agccttcatt tgctctgagc ctttcatcat ggctttcggg taaatgacta aacgagtctc 709981 ggctcctttt ggcgcaacct ccagccagct tgcttcaggt cccattgggt gatccgctgc 710041 aatatcaaag cctaccttct ctgtccaaaa ttgcttcgct ttctgctggt cctcgacata 710101 tacagcaaca gtgccaattt gtttgatcat agggaaacct ccaagttgaa aagataataa 710161 tactataacc tgtttacggc cgaagtaaca taaaaaaatc agccgggaaa ccggctgatt 710221 attaaaatga gcagcttaca acatcgatgt gatttgtgtc taaggcgaaa taaacccagc 710281 ggcgccgtga ggaatcccaa taaaagccgc cgacggatct tctgccaagg atgatcgggt 710341 aaaaccaaaa tgagcggcca ttggttaacc agacataggt aaatcggaaa aggcaaggac 710401 gaatggtgat tggttcaact aacaaaacgg ctccttgaga accctgcggt tttgggggtt 710461 tcgctggtat ttgggaagga ggaggtccct gcggcgcacc gccgaagcct gggctggcac 710521 cgctgccaat accagggccg gagccgccgc caaagcctgg aacagcacca ccgccaatgc 710581 caggaccgga gccgccgcca gagcccggaa cagcgccgct gccaatgcca ggccatggat 710641 atcggtattc atattcaaaa gcaggccaag gctcataaaa atgccccgca aacatataag 710701 gatcaacata atacatgtga taacgtcctt tctcattgta aactgtacat tgcagtttat 710761 gcgggcggac tcttattggt gcattcgcct aaggatatga agctggaatg ctctcagaga 710821 gcagaatcat ttgatttttc tctagtctta ttcacaattc cgatttatca ttttataatg 710881 aaagtgcttc tattacgaaa aaggagacag accgtgaata tcgatcaatt attatatcaa 710941 tatatcatag acaacactgc ggatattact gagaaatggt tcagtttgcg ttgccagcta 711001 aaaggcgagc tatattccgc cagccattta agtgaagaaa cgaaaacact tttaaccgag 711061 cagcatacat ttaccaatat aacaatcgca agcgcatttc tggaggatca aaccgatttt 711121 caagaaaaca tgacaaaatg ggcgcaaaac gttgcgaaaa acagggtaga gcaggatgtt 711181 caagtgcatg aggtcgtaga agccatatcc aattcaagaa tctcattctg ggacgcagtc 711241 gccacattta taaaagagaa tcaggagatt gtgacaaatg aggatgcaga ccgatggaac 711301 cgcattgtga atcagtcgtt cgataagctg attattgaat tctccgagca gtaccaaaaa 711361 ttcatgctga tgaggcttac atctcagcag gaactgatct cagagcttgg ctgcccggtc 711421 atttccattg ccgatggaat cgggatattg ccgcttatcg gctccattga tacaaaacgg 711481 cacaggtcat tttagaaaca gtgccggtcc gctgtgtcga gagaaaaatc acaagcctcg 711541 tcgttgatct ttcgggtgtt ccgattgtgg ataccatggt ggctcagcaa ttgtacaacc 711601 tgtctaaaac acttttctta ttaggcgtca aagccgtatt ttcaggaatt cgcccggatg 711661 tggcccaaac atcgattcaa ttggggcttg attttagtga atatgaaacg tacggcacgc 711721 tgaagcaggc attagaaaac atgggtgtcc gctgtattgt tgaggaattg gaagaaaaca 711781 aataggaagt ttccaggcat atgattgtcc gtcaccgggt gatcatatgc ctttttgatt 711841 tgaacagaaa tcaccattga tttatcgaaa aaaacataat attataattc ttataagaat 711901 actgtgaatt aaaacctatt caacaggggg gaaggtcttt tggtttctaa atcaacgatt 711961 gatccggaag tgattgaaaa aatcatcagc tcgctggaaa cactcgattt cggcacggtt 712021 cagattacgg ttcatgattc tcagattacc caaattgaga aaatagaaaa gcaccgtttt 712081 tcgctgaaaa ggaaagaatc aaaatgataa tgtaaagggc gtttgttttc attaaattct 712141 ccttaaaaca tatacatatt tcatccaatt tttatataat agacctttaa gatcattttt 712201 taggaggatt tttgacatgc aagctacggt tcacgagagt aagcaatcga tcatgcaacg 712261 cattttgaca gtctttgtct tcacattgct gatcgcgact gtcggccttt ttatcggcca 712321 atttgttcct gtcgctttga tgctgccgct ttctattctt gaagtggcga tgattattct 712381 ggccttctgg atgcgcagaa gaaaagcggt cgggtatgcg tttgtatata cattcgcgtt 712441 cgtttccggc attaccttat ttccgatcgt cagccattac gcttccatcg ccggcgccta 712501 tgtcgtgctc gaagcctttg gctctacatt tgtcattttt gccgtcttgg gcacaatcgg 712561 cgcaaaaatg aagaaggatt tatccttcct gtggtcgttt ctgctggttg cggtgctcgc 712621 actcgcagtg gtagggattt tcaacatttt cagcccgtta aactcagcgg cgatgatggc 712681 gtattccgtg atcggaacca tcgtcttttc cctttacatt ttgtatgatt tgaaccaaat 712741 caagcaccgc cacattacgg aagacttgat tccggttatg gcgttatcgc tgtacctaga 712801 ctttatcaac ttgttcatca acctgctccg cttcttcggc attttgagca gtgatgatta 712861 atgaaaaagc gtctgtcatt ggataggcgc tttttgccat acatcaaaaa ggcaggtgga 712921 gtattggtga aaaaacaaat gggcgcatat gtatctctgg cagcagctat ggcgatcgtc 712981 ggcagttctg tcgttgtcgg caagctgatg gtcgaacgga ttccggtctt tctttcctca 713041 ggattgcgtt ttttgatcgc ttctgtcgta ttgctcatgc tgctgttttg cattgaaaaa 713101 gggtttccgg ctttgacgaa aaaagatgtg ttcgtattac tggtgcaatc attcacaggc 713161 gtgtttttgt tcagtatttg cctgctgtat ggggttcaat atacgacggg aacggaaagc 713221 ggcattttga caagcacaac ccccatgttg atcggtattt tatccttttt cctgctgaga 713281 gaaaaaattg agaaaaagac gctgatcggc attttgctgg cggtttgcgg cgtaatggcg 713341 attaatttgt ttggagccgg gagccaagac gggacgccgc acgccttatt cgggaacatg 713401 ctgatcattg ctgcagtcat tggcgaagcg ttgtttacat tgatggccaa gctgctatcc 713461 ccgcatattt cggcactggc gatttcgacc ttcgtatcgc tcttcggctt cctgtttttt 713521 ctcccgtttg ctttgtttga ggcctcttca tttgattaca gcgtgccgac tgttttggat 713581 tggtcgtatg tgctgtatta cgcgcttttt gtcactgttt tggcgtttta cttatggtat 713641 agcggggtga cgaaggtgcc ggcgggtgta tcgggcattt tcacatccgt tcttccggtc 713701 tcagctgtca ttttgtcagg cgtgatattg aaggagccat ttgagtttgt gcatttcatc 713761 ggcattgcat gtgtcatcgg cggcatattt gttacggtca taaagaaaaa acagccggat 713821 gcgtatccgg ctgcagaaga aaagacgcta tagcctgtcc ggatcggacg ggttttttag 713881 tctttaaaca cgctcagcct ttcaaaaaga tcaccaagca tcttcacgaa catgtctttt 713941 tcctcgtcgc tgtagttttc catgacagcg gatattttgc tgaaatggcc gggcagaaat 714001 tgctccaggc gtgctttgcc ttctgttgtc agttcaatgc tgatttttcg tttatcctct 714061 gtgtgatgcc tgcggctgac aaaaccgtct ctcgccagcc cgtctagcag gcctgtaatt 714121 gttgctttcg tgacatttga ccgcttggca agctctgtcg gacttaacct atgatccttg 714181 gcatcaaaga gcagcatcag gattttgaat tttccttctg aaagccctcg gccagcaaag 714241 taatgctcca tcacatgatt catttttttt gaaatatcaa aaagagataa aaacaattca 714301 agagagccgg cgtcaatatt ggcatacgtt tcggcgtgct ctgttatatg cttatatttc 714361 ggtaaatgtt ttaattccat cgcaattagc tcccgtacat tcgttgtgac acgattataa 714421 aggagggaaa accataacgc aacttggctt ggagatgatt gacagctttt cttgggacat 714481 agtaaggtaa tatagttagg cgcctaacta atacatatag agctgaaaag gtggttattg 714541 atatgaaaca tatgttaata gcaggaggcg gaatcggcgg cttgtcagcg gccatttctc 714601 tccgtaaggc agggttttcc gtcaccttat gtgaagcggc ttcagaaaat cgaaaaacag 714661 gtgcggggat tcttcagccg caaaacgcac tggcggtgtt gaaagaactg ggcgtattcg 714721 aagattgctg taagcacggc tttcaaacag aatggtttaa aacgtttgat gaacagggga 714781 atttgctgtt tcaagtcagt gaatcctttt tagacgattc acttccggga cgcaataata 714841 tcctgcgcaa aacgttaaat gacattctca tgaagcatgc cgaggcagtg ggtgtagaca 714901 tcaagtgggg gaaaaaggtt gtcgcctatg aagaaactgc tgaatcggtc actgccttat 714961 gtgaagatgg agaaaagatg caggctgaca ttctggcggg ctttgacggc attcactccg 715021 ttgttcgtga taagatgctg caaaaggaaa cggaaaaaga gcatctcggc atgggagcgt 715081 ggcgctttta tatcgaactt cctgattaca cattcgagga cgcaacattc atgtatagaa 715141 gcggagacac acaaatcggg gtggtgccat tggcacaaca cgctggctat gtcttcgtcc 715201 tccagccttg cacgagcgat tactgggatg aggaagatac ccggtttgat agagtaaaag 715261 agattctttc tggttttcgg gggctggatt ttgtcacaaa gcacatgtca aaacagcatc 715321 ctgtcatctt taacaaactg gagcaggtcg ccgtgcagga gccatggcat aaaggccgcg 715381 tcatcatcgg aggagacgcc gcccacgccg gtgcgccaac cctggcacaa ggagcggcaa 715441 tggcgatcga ggatgccatc gtcctcgccg aagaactcca aaaccacgcc gaccacgaaa 715501 cagcattaca ggcgtactat aaaagaagag ccccacgagc gctcaaagtc cagaacctat 715561 catctgaaat cgtccgccgc aggctgaaag gagagccggg agcggaagaa ctgattgggg 715621 agtgctatgc ggtgttgagg gaagggtatt aaataggaaa agtccagaaa gtgatttctg 715681 gactttttag tcttgctctg ttttattcct tatccgctca atcacctcat gcagcccctc 715741 aggcttataa aactccaccg gtgaactgcc tttctcaaac gaaatcgtct cggcttcaat 715801 cagcgcgaca tagcgcccgt ttacttttgc gagatgaata gaatcgccaa aatccgctag 715861 caatccctta atctctgttt ctccgacttt cattttcagc tgggcctctg gcgtgtgctc 715921 gatgatttgg gcggaggctt cgatgacttg atgggtgtcg aggcgctctt ggatttcccg 715981 tttttcgctt gcttcccaaa tctcaatgtc gtgctcgaac tgcttgagtt cttcgctgtt 716041 gtcttcaaat gtctcgtaga cgtgctcttg taccatgttc atgacctgat ttttcatgat 716101 ttctggcatc gattctccgt actcgacgaa tttcagaaag tcctcaaaat agcgggcgtg 716161 cgaggcctgg tggattttca gttcaccttc ctcgaccatt ccttcctctg gcatgtacgg 716221 gtattggatg cttttcatgt tttttgtcgt gatcgccatt tcgacttttt taatgagaga 716281 agacgcgtca gagatgcggg cgaccttcgg ctcaaaatca catttcataa tgaagacaaa 716341 tgactcatca aagtattttc tcggcacggc cgaagcgacg agaaacacgc cgccgcgaac 716401 cgcgcttgtg tcaaggtacg tgcggacgaa ctgctcgctc agctcattga agtcttcttt 716461 tgtttccgcc agacgcgcgc ggttgaacat gttgtagttt gggttggaat cgagctcgtg 716521 gccgggctcg acgataaaat ggccgatttt cgtcggcacc tgctcggact gcggatggcg 716581 gtcggctttc cgtttaacga tttttttcag ttccccgtcg agaaagtcct tcagctcgct 716641 ttcttcaaat tctcccgtat caagggtctg gaagtgcttg aactgcttgt tcgcctgctc 716701 atctttgcct tccacctgta tgacataaaa ggataaaaac cgaatttcaa aatccatata 716761 taaactcacc ttattcgcgt attgtacagc ttctcaagta tagaaaaaac agcgatcatg 716821 cgtcaattgg gagaacggaa taatcatgac catgaaaggg aaatgtagtc aaatagaagg 716881 catttcatac ggaaaggaat ggttcgatga aggaaacaag cccgattcct cagccgaaga 716941 cgtttgggcc gctcggcaat ttgcctttaa ttgataaaga caaaccgacg ctttcgctga 717001 tcaaactggc ggaagaacag ggcccgattt ttcaaatcca tacacccgcg ggcacgacca 717061 ttgtagtgtc cggccatgaa ttggtgaaag aggtttgtga tgaagaacgg tttgataaaa 717121 gcattgaagg cgccttggaa aaggttcgcg cattttccgg tgacggattg tttacgagct 717181 ggacgcatga gcctaactgg agaaaagcgc acaacattct gatgccgacg ttcagccagc 717241 gggccatgaa ggactatcat gagaaaatgg tcgatatcgc tgttcagctc attcaaaaat 717301 gggcaaggct caacccgaat gaagcagtcg atgtcccggg agatatgacc cggctgacgc 717361 tcgacaccat tgggctatgc gggtttaact accgctttaa cagttactac agagaaacgc 717421 cccacccgtt tatcaacagc atggtgcggg cgcttgatga agcgatgcat caaatgcagc 717481 ggcttgatgt tcaagataag cttatggtca gaacaaagcg gcaattccgc tatgatattc 717541 aaacgatgtt ttcgttagtc gacagcatta ttgcagagcg cagggcgaat ggagaccagg 717601 atgaaaaaga tttgctcgcc cgcatgctga atgtggaaga tccggaaact ggtgaaaagc 717661 tcgacgacga aaatatccgc tttcagatca tcacgttttt gattgccggc catgaaacaa 717721 cgagcggcct gctttccttt gcgacttact ttttattgaa gcatcctgac aaactgaaaa 717781 aggcgtatga agaggtcgat cgggtgctga cggatgcagc gccgacctat aaacaagtgc 717841 tggagcttac atacatacgg atgattttaa atgaatcact gcgcttatgg ccgacagctc 717901 cggctttcag cctttatcca aaagaagaca cagtcattgg cggaaaattt ccgatcacga 717961 cgaatgacag aatttctgtg ctgattccgc agcttcatcg tgatcgagac gcttggggaa 718021 aggacgcaga agaattccgg ccggaacggt ttgagcatca ggaccaagtg cctcatcatg 718081 cgtacaaacc attcggaaat ggacaacggg cctgtatcgg catgcagttt gcccttcatg 718141 aagccacact tgtgttaggc atgattctaa aatatttcac attgattgat catgagaatt 718201 atgagcttga tatcaaacaa accttaacac ttaagccggg cgattttcac atcagtgttc 718261 aaagccgtca tcaggaagcc attcatgcag acgtccaggc agctgaaaaa gccgcgcctg 718321 atgagcaaaa ggagaaaacg gaagcaaagg gtgcatcggt catcggtctt aacaaccgcc 718381 cgcttctcgt gctgtacggc tcagataccg gcaccgcaga aggcgtcgcc cgggagcttg 718441 ctgatactgc cagtcttcac ggcgtaagga caaagacagc acctctgaac gaccggattg 718501 gaaagctgcc gaaagaggga gcggttgtca ttgtgacctc gtcttataat ggaaagccgc 718561 caagcaatgc cggacaattc gtgcagtggc ttcaagaaat caaaccgggt gagcttgagg 718621 gcgtccatta cgcggtattt ggctgcggcg accacaactg ggcgagcacg tatcaatacg 718681 tgccgagatt cattgatgag cagcttgcgg agaaaggcgc gactcggttt tctgcgcgcg 718741 gggaagggga tgtgagcggt gattttgaag ggcagcttga cgagtggaaa aaaagcatgt 718801 gggcggatgc catcaaagca ttcggacttg agcttaatga aaacgctgat aaggaacgaa 718861 gcacgctgag ccttcagttt gtcagagggc tgggcgagtc tccgctcgct agatcgtacg 718921 aagcctctca cgcatccatt gccgaaaatc gtgaactcca gtccgcagac agcgatcgaa 718981 gcactcgcca tatcgaaatt gcattgccgc cggatgttga atatcaagag ggcgaccatc 719041 ttggcgtatt gccaaaaaac agccaaacca atgtcagccg gattcttcac agattcggtc 719101 tgaagggaac cgaccaagtg acattgtcgg caagcggccg cagtgcgggg catctgccat 719161 tgggccgtcc tgtcagcctg catgatcttc tcagctacag cgtcgaggtg caggaagcag 719221 ccacaagagc gcaaatacgt gaactggcgt catttacagt gtgtccgccg cataggcgcg 719281 aattagaaga actgtcagca gagggtgttt atcaggagca aatattgaaa aaacgaattt 719341 ccatgctgga tctgcttgaa aagtatgaag cgtgtgacat gccgtttgaa cgatttttag 719401 agcttttacg gccgttaaaa ccgagatact attcgatttc aagctctcca agagtgaatc 719461 cgcggcaagc atcgatcaca gtcggtgtcg tgcgcggccc ggcgtggagc ggccgtggcg 719521 aatacagggg tgtggcatca aatgatttag ctgagcgtca agccggtgat gatgtcgtga 719581 tgtttatccg cacaccggaa tcccggtttc agcttccgaa agaccctgaa acgccaatta 719641 ttatggtcgg gccaggcacg ggagtcgcgc catttcgcgg tttccttcaa gcccgcgatg 719701 ttttaaagcg ggagggcaaa acgctcggtg aggctcatct ctattttgga tgcaggaacg 719761 atcgggattt tatttaccga gatgagcttg agcggtttga aaaagacgga atcgtcactg 719821 tccacacagc cttttcccga aaagagggca tgccgaaaac atatgtccag catctcatgg 719881 ctgaccaagc agatacatta atatcaatcc ttgaccgcgg tggcaggctt tatgtatgcg 719941 gtgatggcag caaaatggcc ccggatgtgg aggcggcact tcaaaaagcg tatcaggctg 720001 tccatggaac cggggaacaa gaagcgcaaa actggctgag acatctgcag gataccggta 720061 tgtacgctaa ggatgtctgg gcagggatat agataaagaa gactggagac atccagtctt 720121 tttagtcctt tcgaaaaaat ggtgatcgcg ctaaacattg atgcatacaa taacttcagt 720181 ccgccggaag ggcgggctgt ctgcaaaacc tatttttcgt ttttgctagt ttatgttatt 720241 cttatactcg gtatctattt cttttttcaa aggcacacat gacaaaagaa atcctttttt 720301 tatttccgag aaaaaaatgt gaaacgaaat gaaggtttct ttcgtccagt gattggtttc 720361 caaatggttg taataaaaat gatatggtgc gaaacataaa tattccggct tgccgcggtg 720421 tatttattgt tgtgtgatgc cttgattttg tttggaaaga aggaattgga aggcaggata 720481 taaagagcag gtaaatatga atgaagaact taaagtgttt aagaaagtag aggttgccat 720541 gaagaaactt ttttcttaca aacttagctt ttttgtgctg gctgttatac tgttttgggc 720601 aaaaacgtat ttatcctaca agactgagtt taatcttggg gtaaaaggca caactcagga 720661 gatcctcctg atatttaacc cattctcaag cgccgtcttc tttttaggac tggctttgct 720721 ggcgaaaggg cgtaaatcag ccattattat gctgattatc gatttcttga tgacatttgt 720781 gttatatgca aatattttat tctatcgttt ctttgacgat ttcttgacgt tcccgaacat 720841 taaacagtcc ggaaacgttg gaaacatggg agacgggatt ttcagtatca tggccggtca 720901 tgatattttc tatttcttag atattatcat tttgattgcg gtattgatct ggagacctga 720961 attaaaagaa tacaaaatga aaaaacgctt tgcatcttta gtgatccttt ctgggatcgc 721021 actgtttttc atcaacctgc actatgcgga aaaagaccgt ccgcaactgc tgacaagaac 721081 gtttgaccgc aattatattg tgaaatattt aggtttatac aactacacca tttatgacgg 721141 tgtacagacg gctcaaacag agacgcaaag agcctatgca agcagcgatg atttaacaag 721201 tgtcgagaat tacacgacgt ctcattatgc gaaaccaaac gccgagtact tcggctctgc 721261 caaaggcaaa aatatcatta aaattcacct cgaaagcttc cagtcattcc tgattgacta 721321 caagctaaac ggtgaagagg tgacgccttt cttaaataaa cttgcgcacg gcggggaaga 721381 tgtgacgtat tttgataact tcttccatca gacaggccag ggaaaaacat ctgatgccga 721441 gctgacaatg gataactcga tcttcggtct tcctgaaggc tccgcgtttg tgacgaaagg 721501 cgaaaacacc taccagtcgc ttcctgcgat tttagaccag aaggaaggct atacaagcgc 721561 cgtcctgcat ggtgattaca aatcgttctg gaaccgtgac cagatttaca aacatatcgg 721621 atatgacaag ttcttcgacg caagcacgta tgatatgtca gatgaaaatg tgattaatat 721681 ggggcttaag gataagccgt tctttacaga atcgattcca aagcttgaat ctcttaaaca 721741 gccattttat gcgcatttga ttacattgac aaaccattat ccgtttaacc ttgatgaaaa 721801 agacgcgtct cttaaaaaag cgacaacagg cgataacaca gttgacagct acttccagac 721861 agcgcgttac cttgacgaag cgcttgagca attcttcaag gagctgaagg aagccggcct 721921 gtatgacaac tcagtcatca tgatttacgg tgaccataac ggtatttctg aaaaccataa 721981 ccgagcgatg aaagagattc ttggaaaaga gatcacagat tatcaaaacg cacagaacca 722041 gcgtgtgccg ctgatgatcc gcgttcctgg caaaaaaggc ggagtgaacc atacgtatgg 722101 cggcgaaatt gacgtcatgc cgacacttct gcacttagaa ggaattgatt ctcagaaata 722161 tatcaacttt ggtactgatt tattctctaa agaccacgac gatacggtgg cattcagaaa 722221 cggagacttc gtaacgccga agtacacatc agtcgacaat atcatttacg atacgaagac 722281 aggtgaaaaa ctgaaagcga atgaagaaac gaagaatctg aaaacaagag tgaaccagca 722341 gctgagcctt tcagacagtg tcctgtacaa agacttgctg aggttccata aactaaatga 722401 tttcaaagcc gttgatccgt cagactatca ttacggcaag gagaaagaaa tcaaataaga 722461 tgaaaaagag ccttgagcgg gcgcattgcc ttcgctcaag gctctttttt tggttataca 722521 accaacttga aaaaatagat tccatttggt caccaaggct ggctttctct catatcatta 722581 cagtagattt tgaaaccgga ttgaaatcgg acaaattatc ggggaaatgc cttgatagat 722641 tgtgaagatg taccaggttt cgaactcaat attcatagag atgaggggta gagatgaaag 722701 cggtcattct ctgcggcgga aaaggaacga gaatgagtga agtcacgaat gacattccta 722761 aaccgctcgc catgataggc ggcaaaccga ttctatggca tattatgaaa atttatcagt 722821 actacggagt aaacgagttt attctgcttt tgggctataa aggagaaaaa atcaaggaat 722881 actttctcga ctatgaatgg aagcacaaca gcctgacact cgacagctct acgggagagg 722941 tacagatgct ggggcagcct gaaacgtgga aaattacgtt tttggagact ggggtagata 723001 cgctgacagc cggaagaatc ttgcaggcga aagactatat cggtgatgaa acatttctgc 723061 tcacctatgg agacgggctg gccaatatca atcttttcca tctcatcagc tatcatcaga 723121 caaaaggtgc tgccgcgact gtcaccggca ttgacaaagt ctcgcagttt ggcaccttga 723181 cagttgagga tggcatggcg aaaacatttt ctgagaagac atcaagtgat ggaatcatca 723241 acggcggatt cttcgttctt agtccaaagg ttttcgatta tttgccgaag gacgggaaca 723301 cgatgttcga agatgaaccg ctgaagaacc ttgccaaaga tggggagctt gctgtgtacc 723361 gccattacgg attttggacg gccatcgata cgtataaaaa tctcttagaa gtcaacaaaa 723421 tgtggaatca aggacaacaa gtatggaagg tatggtgaat tgatttgagt ttctggaaaa 723481 ataaaaacgt atttgtcacg ggatgcacag gtcttttagg aagctatttg gtgaaagagc 723541 tgatcgaaca gggcgcaaac gttacggggc tagtcaggga tcatgtgcct caatccaatc 723601 tttatcaggg agaacatatc aagaaaatga acatcgtgcg gggctctctt gaggacttgg 723661 ctgtgattga acgcgcgctt ggcgagtatg agatcgacac agtctttcat cttgctgcac 723721 aagcgattgt cggcgtggca aaccgcaacc cgatttctac ctttgaagcg aatatcctcg 723781 gcacctggaa tattctcgaa gcctgccgca agcatccgtt aattaagcgg gtcattgtcg 723841 cttcaagtga taaagcttac ggcgatcaag aaaaccttcc atacgatgaa aacatgccgc 723901 tgcaaggcaa gcacccgtac gacgtctcaa aaagctgcgc agatctgatc agccacacct 723961 attttcacac gtacgggctt ccggtctgca ttacgcgctg cggaaactta tacggcggcg 724021 gagatttgaa cttcaaccgc atcattcctc agacgattca gcttgtgctg aacggggaag 724081 cgccggaaat ccgaagcgac ggcacatttg tacgggacta cttctatatt gaagacgccg 724141 ttcaggctta tctgcttctt gcagaaaaaa tggaagaaaa caatcttgcc ggagaggcct 724201 ttaacttcag caatgagatc cagctgaccg tacttgaact ggtagagaaa atattaaaga 724261 aaatgaacag taatctgaaa cctaaggtgc tgaatcaggg aagcaatgaa atcaaacatc 724321 aatatttatc cgcggaaaaa gcaagaaagc tgctgaattg gacaccggcc tacactattg 724381 atgagggact tgaaaaaacg attgagtggt atacggaatt cttcaaaaag taatgtgaaa 724441 cgaggtgaac aagactgtga ccagcgcgta ttgcaccgtt ttatcaaaag gaagattata 724501 tcaggcagtc gctttgttta agtcgttaga gcaagttgat caagacagtc ccatttttat 724561 actttgcatg gatgaagata cgcaccgcgt gttacagaag ctgaagatga agcagctgaa 724621 ccttgtgccg gtggccgctc ttgaaaatga attgctgctg aagctgaagg aaactagaga 724681 tcaaagtgag tattgctgga cgatgaagcc gatctttctg caagctgtgc tgaacagcaa 724741 tcctgagctg gagcgtgtga cgtatattga cggggatctc tttttctatg cagatccatc 724801 gccgattttt gaaaaccagc cggactgctc ggtgttgctt tcacgagggg atattgtaat 724861 cccttctttt gagaaagagc agattgacat gctgcagcgt cttttaggca gatataattc 724921 cgggtttatc agcttcaagc atgatgatgc aggcacggat tgcttggagt ggtggaagga 724981 acgctgtctt gaggaatgca aaaatgcacc gggtgaaggg aaattcggtg atcagggcta 725041 tttggattat atgtctgagc tgtttccgaa tgtgtgtgac attacaacac ccggcgtgaa 725101 catcggccat tggaattatg gacagcatac gttttcctgg aaagatggcc ggatcgtgct 725161 ggaggatggc agtccgctga tcttttatca tttcagcgga taccgaatcg tcagcatcaa 725221 tgaaatcaaa cagattcatg aaacaacccg cacagatctg ccgtttgtgc atgaactgta 725281 tcaagagaca ctgccgcata tcattcagca catgcaaacg ttagaccctg aatttaacgg 725341 ttttgcttca aaagatgaca acaaataaat gagtaaatac aggaagtgaa aatgaagtga 725401 aagcaagcgt tattattcct gcatataatt cgaaggagcg tctttacaac agccttctgt 725461 cattaaacca gcaggagtgc gatgaagaat ttgaagtcat tgtagcggac aatggctctg 725521 aggacgggac gctctcgatg cttgagtcat ttcaagctga ttttccgctg atctttacac 725581 ggattaaaga aaacaggggc attgcgtacg gacgaaatca ggcgcttcgc aatgccagag 725641 gagacatcct gattttccat gacagcgata tgcttgcggc aaaggacctt gtggcaaaac 725701 atattaaagc ccatgagaac gaagagaatc tcgtcgtgtg cgggttgttt tggaaacgga 725761 tctacagttt ttactatgaa cgatttgaag aagaacataa ggaacagctc gcaaagctca 725821 caggtgaaat gccgaagaaa gacaaacaaa agctgctgga ggaagcggac atcaaaaacg 725881 gaagctttct tgataaaagc tttgacctcg ataccgactt tatagacgtg ctcaagaaga 725941 ttttagatga gtacggcgat gacttgaaag gctatcatat gccatggcgc ttttttatca 726001 cgaataattc ctctgtgaaa cgcaagcatg tggttgacct cggtttattt gacgaaggca 726061 ttgtgcggta cgggtttgag gattatgacc tcgggatcag gcttcatcag gccggattga 726121 ccttcaggct tcgccgtgat attgtcagtg ttcatcagga acatccaagc aattgtaagt 726181 ctgtagacga tattcgggca aacattgcct atatgtgcga taaatacaat aacatccgct 726241 ccttagacgt tcatctcgct tttaatgggc cgttcccgcc tgacatgacg aacagaatca 726301 tggctgatat tcaaaagctg ctggaatcac agaaatatga tatgctgctg aatctgtttc 726361 ttgagcttct gcatgttgtt aaagagcgca acattgatcc ggattggcga aagaaatccc 726421 caagggtgac ggcgaaaagc tttgatttgc aaactgtccg caagcttctg cctaaggcga 726481 agaaaaagct aggcgtgaac gattttgcca acgcactgta tgcgcttgtc aacgatttgc 726541 tgcacgtgga tcttagatca ttggatgtgg tataagtgag tacatttcat ttttcaacga 726601 tagtgtcaag gacacatatc tttaagctca tgcctatgat tcattctctc catgagcatt 726661 gcgatgattt tcatttatat gtgctgtgtg tcgaccagaa agcgtatgaa ttgcttcagc 726721 acgttccatg ggagcatgta acctttgtgc agctgcatga aatggaagac ccggagctgt 726781 tgaaagcgaa aagcaacaga acgtttcatg aatattgctg gacgttaaag cccgcctttt 726841 tgtttcatgt gatgagcaag tgggatgacg ctgaatactt tgcccatatg gatacggatc 726901 tatttttctt ttctgatccg gcacgtattt ttgcagaaaa cccaacggcg tctctgtatt 726961 tgactgatca tcgtaattcg ccgcgcttca tgtcctacta cgaccgaacc ggacgcttta 727021 atacaggctt tgtcggcgcc ggtaatacaa aggaagcata tgaagcggtg tggcagtgga 727081 gacaggactg tattgaattt tgcacggtcg aaatggatac ggaacgaaag acatatggtg 727141 atcaaagata tgtggagaaa tggccggagc agtttaaagg tgttcatgtt gtcaaatcca 727201 taggagccaa tacagcgctt tggaatatcg aaaactataa ggtcgggcaa aaggacggcc 727261 gcgtgtatat agatgaaacg ccgctgattt tctatcattt ctctgggttt acgctggtga 727321 cagaaaaaga gtttaatctt tgctggtact accggattga agacgaagcg acaattaaga 727381 tgatttatat gccctatata ttaaatctga aaagatggat tgatgaaata cagtcggcgt 727441 ttccggactt tgcggatggc tttatcccga agcacgcagt gcctgacact cattttatcc 727501 agctggatta aaaaaccccc tgccgcctgg caggggtttt ttcagctatg ccattctctc 727561 agcttctggt cacttggcaa taggaaggca aggatgccga ggacagggag aaaggcaatg 727621 gcgatcatcg tcggggtcag tcccgcggca tcaatcagag cgcccagcgc cacagcgccg 727681 attgcgccca tcccgaaggc aagcccgacg gttaaaccgg acattgtgcc gatttttcca 727741 ggaactagct cctgtgcgta gacgaccgtt acagaaaagc tcgacatcag aaccaagcca 727801 atcaatgcga gcacgccgta ggcgagaacc gggccggcaa atggcagcac aatcgccagc 727861 ggcgccgagc ataacagcga accgaggata acgaagcgtt ttccaaaacg gtctgcaagc 727921 gggccgccga gaaacgtgcc gatcgcgccg aacagcaaga agacaaaaat atagctttgt 727981 gcctgctgaa tgcttacgtg ataggtatcc atcgcgtaaa acgtgtaaaa gttaccgatc 728041 gcactcgtat accaagaacg agcaaaaatg agaaatataa taataataag agcagataca 728101 acagatttgg tgatggccgt gttttcagcc gttttctttt gcttgcctga tttctgggca 728161 aggctgccga gacgtgaggc gtaccatttc gcaatataca tgagaaacat aacagcaagc 728221 gcggcgacaa gcgtgaacca aacagcgccg aattgcccga gcggcacaag gatcagcgcg 728281 gtgatcagcg gtgccatcgc ctggcctgag tttccgccca cctgataaat cgattgggcg 728341 agcccgcgtt ttgtgccggc ggccatatac gccacacggg agccctccgg atggaaaatg 728401 gccgagccta atccaatgaa aaacacacag cataagatcg ttatgaatga cggggcaaat 728461 gcaaggccca aaatgccaag catgctggcg gtcaaaccga ctggcagcgc atacggccgc 728521 ggccgtttat cggtatacca gccgacaaca ggctgcatga cggatgacac catgtttaat 728581 gtgaaagcaa tgatgccgag ctgtgtaaac gtcaggctca tggagcgttc caaaataggg 728641 aacatggccg gaatcacagc ctgaagcgaa tcgttgagca tatggcaaat tccgataata 728701 atcaaaatcg gatacaccgt ggtgcctggt ttttgaactg ttttttcttt taacggggcg 728761 gcgatagcca ttgagtctcc tccttacata tataaccaaa gcataccacc atattattca 728821 taaggtgaag aatttatcaa gaggaaaaaa gattcttatg aaagaaatac cgtcagcctg 728881 attagcagct gacggtattt tcgatattca aaatgtgata tagctcttca agcttacgaa 728941 tctcataggt tggtatgatc tctggcacat tcggcttcat gtcagggttc atccagcaag 729001 tatcaagccc ggcgagctgt ccgcctttga tatcagcagt tagtgaatcc ccgatgatta 729061 atgtgtgctc tgctgaaaat tgaggaatcc gttcaaacac gtaattgaaa tattccttca 729121 tcggcttttg gaagccggtg tcttcagaaa cgaaaatgtc cttgaagaat ggaaataatc 729181 ctgaatcacg gagacgctta tattgtgtgt gagacacgcc gtttgtcacg atgtacaaat 729241 caaactgttg ctgcagattt gagatgagat caaatgcacc gtcaataagc tgatgtcctt 729301 cttcaagaaa gcggcggtat ttttgctcaa gcaaagcgcc gtccgcttcg taaccgtact 729361 ccttgagcaa agcggaaaaa cgtgtgttta cgacttcatc ccgtgtcatc ttaccttctt 729421 caaaggctct ccagagacct tgattgatgg ttttatactg cgccttcatg tcatttgtta 729481 aaggaatgtt ctgatcttca aacagcaaac gcagggctaa agcttctgcc gcttgaaaat 729541 caaggatggt atcatctaca tcaaataata aagtgcggta tcgcttcatc tgtgtgtctc 729601 cctttctcat atgtattcaa agtatagcac ataaaaaaag gaaaaagccg gcgggtgagg 729661 caccgccggc tgaaaagaga ttatttgttt aataagctgt gttttctcga atataggaag 729721 taaaccagcg ttccgacagc gatccagatg acaaatgaaa gccatgtgac gccgggaagg 729781 ctgtacatga accaaaggca gatgcctgcg ctgataatcg gcacaaccgg aacgaatggc 729841 actctgaagg acgctttgat ttcaggatgt ttctttctta acacaatgac agcaatggaa 729901 atgaccgtaa acgcggcaag tgttcccatg ttcaccagat gggccagcgt tccgaggtta 729961 ataaagccgg cgattcccgc tgcaacgatc cctgtcagcc atgtgttgcg gaacggggtt 730021 ttaaatgacg gatgaacctt tgcgaacaat ccaggcagaa ggccgtctct gctcatggca 730081 aatgtcaagc ggacctgtgc gtacagcaaa gcgagcatca ccgtcgtaat cccgataatc 730141 gcaccgacag aaataattcc ggcaacagcg tcctgtccga cgaatttcag cgcaaaggat 730201 acaggatctc cgacattcaa tttggcataa ggcatcatgc ctgtcagcac aagcgatacc 730261 gcgatgtaca gaaccgtaca gacggctaga gctgaaataa tgccgacggg catgtttttt 730321 tgcggatttt tcacttcctc tgatgcgtta gaaaccgcgt caaacccaag gtacgcgaag 730381 aatacagtgg cagcgctaag tatgacgcct ttcatcccga atggcataaa aggagaccag 730441 ttatccggtt tcacatagcc gatgccgaca ataatgaaca ataatatgat cgcgattttc 730501 atcagtacga tgacgttgtt aaagcgtgtg ctttccttga cgcctctgct gacaatcgca 730561 gtgatgagga gaatgatcac cgcagccgga aggttaaata cggcgcccgc catgcttccc 730621 ggcgctcctg tcagtgcagc cggaatatga agattgaagc cggcaagcag tgattgaaag 730681 tatgaagacc agccggtggc aaccgccgac agtgcaatga catattcaag catgagatcc 730741 catccgatca aaaaggcgag cagctctcca agtgtcacgt atgagtatga gtacacgctt 730801 cccgaaatcg gaatggaaga cgaaaactca gcataacaga aagcagccag cgcacaggcg 730861 agccccgcta aaataaacga tatgatgagg gcgggacctg caccggtcgc tgccactgtt 730921 cctgtaatga caaaaatccc tgtaccgatg acacaaccga taccgagcaa ggttaaatca 730981 aatgcgctta acgtacgggc aaggcttttt gacttgctct gcgcactcaa tgtttcaagc 731041 ggtttttttc taaataatga actcatcaaa agttcctcct agaaatattc aaaatattct 731101 aatcattata tgcagttctt gttgtattat attgtcgaaa tttgacgtag tcaataaaat 731161 atttttctgc tttaaatgat agaagcgaaa cagcgttgtc gtatcatagg atagtaattt 731221 ttactaatcg tatattcaat tttatgcaag atgaaccgat agaaaaaata gattcgccca 731281 tattttgatt tgcggttata aaggagatgc tgaccatgtt tcaatatgaa gagttgaata 731341 aacagtttat cggcgggaaa tggcaggagg gcagcagccc aaatgtattg gaaaacaaaa 731401 atccttatac tcaaaaaaca ttcacaacat tccgtaaagc gactgctgac gatgtagatg 731461 aagcgtatcg ggcagcggcg ctggcaaaga aaaaatggga tgcggtcaac ccgttcgaga 731521 aaagaaccat tttagaaaaa gccgtcacgt atattgaaga aaatgaagaa gccattattt 731581 atttgattat ggaggagcta ggcggtacaa ggctcaaagc agcttttgaa atcggtcttg 731641 tcaaaaacat cataaaagaa gcggcaacgt tcccaatccg catggagggg aaaattcttc 731701 cgtcaacaat agatggcaag gaaaacagat tatatcgcgt gccggcaggc gttgtcggtg 731761 tcatcagtcc gtttaacttc ccattctttt tatctatgaa atcagtggcg cctgcactcg 731821 gagccggcaa tggcgttgtg ctaaagccgc atgaggaaac gccgatttgc ggcggaacgc 731881 tgattgcgaa aatttttgag aacgcgggaa ttccagcggg gctgctgaat gttgttgtca 731941 cagacattgc tgaaatcggc gacagcttcg ttgagcatcc agtgccgcgg atcatctcat 732001 ttaccggttc tacgaaagtc ggcagctaca tcggacagct tgcgatgaag cattttaaaa 732061 agccgcttct tgagcttggc gggaacagcg ccttcatcgt acttgaggat gcagatatag 732121 aatatgcggt caatgcggcg gtgttcagcc gatttacaca tcaagggcag atttgcatgt 732181 cagccaaccg cgtgcttgtt cattcttcta tttatgacaa gttccttgag ctgtaccagg 732241 caaaagtgga atcgctgaaa gtcggcgacc caatggaccc tgatacgatt atcgggccat 732301 taatcaacag cagacagacg gacgggctga tgaagactgt agagcaagca attgaagaag 732361 gcgctgtacc agtgaagctt ggcggattta acgggacgat cgtggaaccg acgatcttaa 732421 aagacgtcaa accgttcatg agcattgcca aggaagagct gttcggacca gtcgtctcct 732481 ttatgaagtt tgattcagaa gacgaagcgg tggatatcgc aaacgaaacc ccgtttggct 732541 tgagcggtgc cgtacatacg tcaaatcttg agcgcggcgt ggcttttgcg aaacgcattg 732601 aaacaggcat gattcacgtc aatgacacga ccatcaatga tgaaccgaat gtagccttcg 732661 gcggtgaaaa gcaatcaggc ctcggccgtt taaacggtga gtggagcctc gaagaattta 732721 caacgctgaa atggatctcg gtccagcacg aaaaacgcag cttcccttat taatgaaaag 732781 gagtgaatgg aattgaccat aaatacggaa aaagaaaccg cagatattct ggacgcattt 732841 atcaaagtag ccccttattt aaacagcctg gttcaggatg atattacaat cggcatttat 732901 gatacggaaa aactgctcgt gaatataccg gccaaaacct tttcgctgaa cgtaaaagcc 732961 ggcgatccgc tgcaggaagg ggatatcatc acagatgcca tccgcagcaa tcagaagaag 733021 acgagcatgg ttccgaaaga attgttcggc ttcccattga tcgcgcgtgc catcccgctg 733081 cacgacgaga atggaagagt cattggaggc gtcggcctcg gaacgagcct tgaggagtcg 733141 tcaaagctgc atgatgtcgc ggaaagctta tcagctgttg ttgaacaaac agccgcggct 733201 atttccgaca tttctgaatc aattaacggg ttttcaactc aaatgtcggg catttcctct 733261 caggcgaaaa aagtaagcga aagcgccggt gaaatcgccg atatttcagt aactgttaaa 733321 ggcatctcgg accaaagcaa tctgctcggc ttgaacgccg cgatcgaagc ggcaagagca 733381 ggggagtccg gaaaaggatt ctctgtcgtc gcagatgaga tcagaaagct agcgacgcat 733441 tcaaaagaaa atgtcggcca aattgaccag attacgaaaa aaatccacag cctgctgaaa 733501 gggctggagg aatccattga gtcgattaac cagcatacag acggacaagc cgctgctgtt 733561 gaacaaattt ccgccacgat gcaggagatt tcaggaagcg cgcagcatct tgcgaaaatg 733621 gccgaaaaag cgcttgagga agagtaagag accggggaca aacatccccg gtctttttct 733681 tatcctgcat ttccatgaaa ttcgtctgac gttttactag ttttattcca gcggctgatt 733741 taaaatgtac acatgaactt acgtgaggat tgataggaac catgagcata ttaaaagcgg 733801 aaaatcttta taaaacatac ggagataaaa cattatttga ccatatctcc tttcatattg 733861 aagagaatga gagaatcgga ttaatcgggc cgaacggaac aggaaaatca acgctgttga 733921 aagtgattgc cggcttggaa tctatcgaag aaggagaaat cacgaaatcc ggaagcgtgc 733981 aggtcgaatt tcttcatcaa gacccggagc tgcctgcggg gcaaacagtg ctggagcata 734041 tctattccgg tgaatcggct gtgatgaaaa ccttgcgtga atatgaaaaa gcgctgtatg 734101 aactggggaa agatcccgaa aatgaacagc gccagaaaca cctgctggca gcacaagcga 734161 aaatggacgc gaacaatgca tgggatgcaa acaccttggc aaaaaccgta ttgtctaagc 734221 tgggcgtcaa cgacgtaaca aaaccggtca atgagctctc aggcggccag aaaaaacggg 734281 tggccattgc caaaaactta attcagcccg ctgatttgct cattttggac gagccgacaa 734341 accatttgga taatgaaacg attgagtggc ttgaagggta tttaagccaa tatcccggcg 734401 ccgtcatgct ggtgacgcac gatagatatt tcttaaaccg tgtcaccaac cgcatttatg 734461 agcttgaaag aggcagcctc tacacttaca aaggcaacta tgaagtgttt ttagaaaaac 734521 gcgcggaacg ggaagcgcag gctgagcaaa aggaaacgaa gcggcaaaac ctgctgcgcc 734581 gcgaactggc ttggctcaga cgaggagcga aagcccgctc cacaaaacaa aaagcgagaa 734641 ttgaccgggt agagacgctt aaagagcaga caggccctca gtcatcaggt tcactcgatt 734701 ttgccattgg ctcgcaccgt ctcggaaaac aggttattga agcggagaac gtcatgatcg 734761 cttatgacgg ccgcatgctc gtcgaccgtt ttaatgaact tgtcatacca ggtgaacgga 734821 tcgggatcat cgggccgaac ggcatcggga aaacaacgct gttaaatgcc cttgccggcc 734881 gtcatacgcc ggacggaggc gatattacga tcggacagac ggtcagaatc ggctactata 734941 ctcaggatca tagtgaaatg aacggtgagt taaaagtcat tgactatata aaagaaacgg 735001 cggaggtcgt aaaaacggca gatggcgata tgattacagc tgaacaaatg ctcgagcgtt 735061 tcctcttccc gcgttcgatg cagcagacgt atatccgcaa gctgtccggc ggggaaaaac 735121 gccgtttata cttgcttcag gttctcatgc aggagccgaa tgtcctgttt ctcgatgagc 735181 cgacgaacga tttggatact gaaacattaa gcgttcttga ggattatatt gaccagttcc 735241 caggcgtcgt catcaccgta tcccatgacc gctatttcct tgaccgcgtc gtcgaccgtt 735301 tgattgtatt tgaaggaaat ggtgtcattt cccgctttca aggctcctat agcgactata 735361 tggaggagtc aaaagcgaaa aaagcggccc caaaaccggc agctgaggaa aaaacggctg 735421 aagccgagcc gaagaaaaaa cggaaaaagc tttcttacaa agaccagttg gaatgggacg 735481 gcatcgaaga taaaattgcc cagctggaag aaaagcatga acagcttgaa gctgacatcg 735541 ccgcagcagg cagtgatttt ggcaaaatcc aagagctgat ggccgagcag gcgaaaacgg 735601 cggaagagct tgaggctgcg atggaccgct ggacagaatt gtccctcatg atcgaagaac 735661 tggaaagcta aaaagcgtgg ccgcagcagg ccgcgctttt tttcacataa tggacaaaaa 735721 cgaaccggcc tgcttatgtt aggataaagt tgtgtgtcag cggcacatgg aaaactaacg 735781 gagatgatga agtatgacat gggcgatcgt gatgttaatt ctcatgagtc tggtgaaaat 735841 cgtattaacc tgtcttccta caggcgtcat agaatggctg ctcggcaaat ttgaagtgca 735901 cgccaagctg agtgacgaaa atgcgagtct ctctctagat ggaaaacgcc tcgagggtgc 735961 agagaagcag aaagtgattg atcaatttaa cgaagctatc ttcctggaaa aatattatat 736021 ctatccaggt gatgaagagc gttatttaca tccggaaaac ggcggcacgc ctctggtgat 736081 agatacaaaa aaaggaaaaa aagacgtgaa gctgttcgtg taccgctacg acgaccatat 736141 cgacgtcgtg aaacagtaca agaagaaagt gatcgcgtat cgagtgcttt ctgaaagcct 736201 tcaaaaagag tctctgtcag tggcgggaag tttagcttaa acaggaaagt gaaagacggg 736261 tgctgtatgc tgctcgtctt ttttattgtt ttttaaaact taacgtttac gttaaggttc 736321 aaaaggtgta taatggtaac agaaacggcg aagggggatt taccttggaa tggatgaaga 736381 ttgatcaagt ggccaaaaga agcgggctga caaagcggac catccggttt tatgaagaaa 736441 tcggcttgat tccggcgccg aaacggacag acggcggtgt aaggctttat tcagaggatg 736501 atatggagga gcttgagaaa gtcatcagca caaaagaggt gctcggtttt tcccttcagg 736561 agcttcagca tttcatggaa accagccgcc agctagagtt aaacaaagag gggtatttgt 736621 tgtcactgga tcctaaggaa cggaaagaaa aactggagga aattcaggaa accctgaatc 736681 accagctgga tttgattgat gagaaaatcc gcacattcca aagctttaaa gaacgcctgc 736741 agggcatgaa aggcaaagcg gaacgcgcca ttcaatcaat cgaatgaaaa gtttgttaaa 736801 cgctattttt gtagcgtttc ttttaatgga ataaagatgg aggttaggtc aaatggataa 736861 gacaacacaa gtgaatcaga aaacgggttt gctcagccag ccaaaagcgg tatgggctgt 736921 cgcgtttgcc tgtgtgattt cttttatggg aatcgggctg gtcgatccaa ttcttccggc 736981 cattgccgca caattgcatg cttcacctag tgaagtatca ctcttgttta caagttattt 737041 gcttgtaacc ggatttatga tgtttttctc aggagccatt tccagccgca tcggcgcgaa 737101 atggacatta attctcggac ttatttttat tattgtgttt gcggggcttg gcggcagctc 737161 aagctcaatc gctcagttag tcggctatcg cggcggctgg ggattaggga atgctttgtt 737221 tatttcaaca gcgcttgcgg tcatcgttgg cgtgtcagtc ggcggcagcg cccaagcgat 737281 tattttgtat gaggccgcgc tcggtctcgg gatttctgtc gggccgcttg caggcggaga 737341 gctcggaagc atttcatggc gcgcaccgtt ttttggagta tctgtcctga tgtttattgc 737401 gttaatcgcg atttctttca tgcttccgaa gctgccgaaa ccggcgaaac gcgtcggtgt 737461 gtttgatgcg atgaaggcac tcaaatataa aggcctgctg acaatggcgg tatcggcatt 737521 cctatacaac tttggatttt ttattttgct agcttattct ccgttcgtac tggatttaga 737581 tgaacacggt cttggatatg tcttcttcgg ctggggcctt ctgctggcga ttacgtcagt 737641 ctttacggcg ccgctcgtgc acaaagcgct gggcacagtg cgttcgctag tcgttctctt 737701 tatcgccttt gcggccattc tcgttattat ggggatctgg acagaccatc agactttgat 737761 tattacatgt atcgttgtcg ctggtgctgt cctcggtatg gtgaatacga tcatgacaac 737821 cgctgtgatg ggttctgcgc cggttgaacg ttcaatcgcg tcttcagcct acagctcagt 737881 ccgcttcatc ggcggcgcgc tcgccccgtg gattgcagga atgctgtcag aacactttac 737941 tgcaagcaca ccatatacag taggcggaat cgtcgttttt gtcggcatgc ttgtccttct 738001 catgggacgt aaacatcttg ctggaattaa ggcggggcat taataacgaa agacactgcg 738061 catatgcagt gtctttttat tcgttataat gcatcataat cgaattggtg caggaaagga 738121 caacctttat gacacaattt tactattttc cggctgaaaa ctccctttag aaaccggttt 738181 tttcggtcag caagaacggc gttcgcggaa agggcatccg cttcggtcag gcattgatgc 738241 ggctgggatt tatcttgcag aagctgagaa tgtgtccgtt catttacgat tgccatttca 738301 gtgatggttc atgctgtaga ggggacgttt gccatggata aggcaaaacc tgacgaatat 738361 gatcagaaat gtttagaaac gctctatcaa tacatacaca gcgtcatgaa aaacagcttt 738421 tctcggtcga gtggtttacc gcttgggaag atgaggagga ttttgagctg tctgccaaaa 738481 gagagctgac acttgatgaa ttcacatctc cattgcagct cattttaaaa gacagagagc 738541 ttttgagaat cgttcagaaa aaatggcagt aaaaaacccg ccctttagca ggcgggtttt 738601 tttataaatt aaagcacttt cgtcgtccaa gactcgcagt tccacgtttc tgtcgcaata 738661 tccatataaa agtctggctc gtgggaaatg agcagaatgg agcctttata ttctttcagg 738721 gcgcgcttga gctcttcctt ggcatcggca tccaagtggt ttgtcggctc atcgagcacc 738781 agcaggtttg tttctgagtt gattagcttg cacaatctga ctttcgcttt ttcgcctccg 738841 cttaatacgg agacgcggct ttcgatatgc tttgtcgtca gcccgcattt tgccagagcg 738901 gcacggattt catactgcgt ataagaaggg aattcgctcc atacttcttc gatgcacgta 738961 ttgttgtttg tttccttgac ctcttgctcg aaatagccgg tatagatgtg ctcaccgcgt 739021 tcaacagagc cttcgagcgg ctggatttca ccaagcaaac ttttcagcaa tgtcgttttt 739081 ccgatcccat tcgcgccgta aagggcgatt ttttggccgc gctccatgcg gaggttgagc 739141 ggacgggaca gcggggaatc gtaaccgatc acgagatcct tcgtttcaaa aatcagcttg 739201 cctgacgttc tcgccggctt aaagtggaat tccggctttg gcttttctgc cgcaagctcg 739261 atcatatcca tcttatcgag tttcttttgg cgggacatcg ccatgtttct cgtgctgaca 739321 cgcgctttgt tgcgggcgac gaaatccttc agctccgcga cttcctgctg ctgctttttg 739381 taggccgctt caagctgctg ttttttcacc tcgtagactt ccataaactg atggtagtcg 739441 ccgacataac gtgtcagctc ttgattttca acgtgataaa tcaggttgat gacactattc 739501 aagaacggaa tatcgtggga aatcaggatg aacgcgttct cgtattcctg caggtagcgt 739561 ttcagccatt caatatgctg ttcatcaaga tagttggtcg gctcatcgag aagcagaatt 739621 tccggctttt caaggagaag cttagcgaga aggacctttg tgcgctgtcc gccgctcaaa 739681 tcggtgacat ctcgctctaa accgatatcg ctcaaaccga gaccgcgggc gatttcttcc 739741 accttggaat caatgacata aaaatcattg tttgtcagcg cgtcttgaat gacgccgact 739801 tcttcaagca gcttctcgag ctcgtcggga tcagcctcgc ccattttgtt gtaaatctcg 739861 ttcatttcct cttccatcgc aaataaataa tggaatgcgt ctttcaggac gtcgcgaatg 739921 gattttcctt tttccagcac ggtatgctga tcaaggtatc cgacacggac attttttgac 739981 cattcgactt ttccctcatc aggttcaagc tttccggtaa taatattcat gaaggttgat 740041 tttccttcac cgtttgcgcc gatcaagccg acgtgctcgc cttttaacag gcggaaggaa 740101 acgttattaa aaatggcccg gtccccgaaa ccgtggctta aatcctttac agataaaata 740161 ctcatgttta cacctctatc gttatcaaac acgcacaatc ggcgtgtaat attcaccctt 740221 ttgattataa aggaggattc ggaatgttga aaggtatagg aaagaaaaag aaaaattgcg 740281 ttccgggcga ggttttgaga tactatggaa tagatttcag gaattgagga gaacaaaatg 740341 acgcaaactt ggccattttt acataatgca caatcattta tacaagagaa ttggaatgct 740401 tccggctttc aaaagccaac ccctgttcag gagcaggcag cccagctgat catggacgga 740461 aaggatgtca ttgcagaatc gccgacaggc acagggaaga cgctggcgta tgcgctgccg 740521 gtcttggagc ggatcaaacc agagcaaaag catccgcagg cggtgatttt agcgccttcc 740581 cgtgagctgg tcatgcagat ttttcaggtg attcaggatt ggaaagcggg ctcagagctg 740641 cgcgcggctt ccttaatcgg cggggcgaat gtgaagaaac aggtcgaaaa gctgaagaaa 740701 catccgcata tcatcgtcgg cacgccaggc agggtgtttg aactgattaa agcgaagaaa 740761 ctcaaaatgc atgaagtgaa aacgatcgtg cttgatgaaa cggatcagct cgtcctgccg 740821 gagcatcgcg aaacgatgaa gcaaatcatt aaaacaacat taagagaccg ccagcttcta 740881 tgtttttctg ccacgctcaa aaaggaaaca gaggacgtgc tccgcgaatt ggcgcaagag 740941 cctgaggtgt tgaaggtgca gcgaagcaag gcggaggcag ggaaagtgaa gcatcaatac 741001 ctgatttgcg accagcgcga caaagtgaag ctgctgcaaa agctgtcaag gcttgaaggc 741061 atgcaggcac tcgtatttgt gagagacatt ggcaacctga gtgtatatgc ggaaaaactg 741121 gcatatcacc acgttgaact cggcgttttg cacagtgaag cgaaaaaaat ggagcgagcg 741181 aaaatcattg ccacattcga agacggagag tttcctcttt tattggcgac tgacattgcc 741241 gcacgcggtt tagatattga aaacctgcca tacgtgattc atgctgatat tccagatgaa 741301 gatggctatg tccacagatc aggacgaaca ggccgggccg gaaaagaagg caacgtgctg 741361 agccttgtga caaaattgga ggaatctaag ctgaaaaaaa tggcgaagaa gcttggtgtt 741421 gagctgagtg aagctgtgta tgcaggcgga aaactgaaga cgaaataaaa agaagggcga 741481 agagcccttt ttttgttgta aaataataga aaagattttg cgcggaggtg ggaaaatggc 741541 ttcaatagac aggtttcaag taatgcagga gccagagctg aaaatccttg aacactggtt 741601 tgagaatgag gataccagac ggagaatgga tgggatgctg ctattagatg agtggtatgc 741661 acgagtaaat aaagataaac acgatactgt catcatggcg tatgatggac agctgccggc 741721 agggatggtc gttattgagt tcggagagga gcggacatat attggattga tcgtcaatcc 741781 tttgtaccgg cttaaagggt atggaaaaca gatactgcaa aagctgatga ccgaacctga 741841 ttttactagc gtgcgagaat gggtggcatg cattgaagaa gacaatcgaa tcagtttagc 741901 ttgctttcaa gcagcaggat tcactttaga agacacggaa cctgatgaag atggttttct 741961 tacgctgatt cttcgcaact gatctcatcg aaacacaaaa ggagggcaaa aagccctccc 742021 gttttcatct tcattcagct cggatcactg accttgatca gctgtttccc tttattttct 742081 cccttaaata aaccgagaaa cgcgtcagga atgttttcga agccttctgt gatggtttcc 742141 tcgtaatgga gtttaccagc cttcagccat tctgccagct gttttgctcc ctcagaaaaa 742201 cgatcggagt agtcgcttac gataaagcct tgcatcagcg acttcgtttt aatgagtttt 742261 gattggacac gagggcccat gtcatctgct tcgctttctg cgttatagga agaaatggcg 742321 ccgcacaccg gaatgcgggc aaattcattg agcagattca tcaccgcgtc tgaaatcggt 742381 ccgccgacat tgtcaaaata cacatcgaca ccgtcaggac aagcgttttg aagcgctttt 742441 tggatatcat ccgctgtttt gtaattgatg gcttcgtcaa actgaagctc ctgttttaaa 742501 tagtcgattt tttcatcaga gcccgcgatg ccgacgactc gcgcgccttt gattttggca 742561 atttgcccga ctgttgaacc gacggctccg gcagctcctg agacaaccac ggtttcgcct 742621 tccttcgggc gtccgatgtc cagcaatccg aagtatgctg ttaagccggt cattcccaaa 742681 atgccgagat aggccgaagc gggagcaagg cttgtatcaa tttttcgcaa ggcagactcg 742741 ctcacagcgg aaaattcctg ccagctgaga tttccgatga cgatatcgcc ttttttcaga 742801 tgattcccgt ctgacacaac ttcagcgata acccctccag aaagcgcttt atccaaggcg 742861 aacggctcaa catatgactt cgtatcctgc atacggccgc gcatataagg gtcaaccgat 742921 acataaagcg ttttgacaag cacttcccct tgcttgggtt caggaaccgg aatggtttca 742981 aagcgaaagt cttcatgaac aggaatacct tgtggacgtc ttgctaattg aatttgctgc 743041 tgagatgctg tcattttcat cctcctatca cttggttgac accactgtaa catggacagg 743101 agaggaaata caaaaggtaa gctggcatac aaaaaaggtt atagatgagc ttatgctttc 743161 tacaagctct tttgttttaa aagttctctt tagtcattta tcattattag aaaacagaac 743221 agaaaaagag ctcctgtaca cctagctaag attggctagt gtgtatgtcg attctttttc 743281 atattcttgc aagcatctgc gagggggagc ttagtcgttc acattttgct ttcgcatcaa 743341 tctgcaatag caaagtctat gcgatttttt tacatcagca aagatttgtt caattttttc 743401 cttttatgcc gagtttttct gaaacagata attgatggta ctcaaccatt ttcttttggt 743461 caataaagta atgtttactt attaattaaa cacgcgaaaa agcaaacgaa aacataatta 743521 aattttatat atttattaaa agcttatatg tttatttacc ttttttttga attgtaattg 743581 agaaaatcca tatattgcgg acactaataa aagaatacct gctgaaacat aaactaaacg 743641 aactccaagg aaatctgaaa tagcccctat agccagaatt gaaaacataa aaatgaactg 743701 tactaaagaa gaccttgcag acattatatt aattcgagtt tgctcggttg ttatgttctg 743761 aataagtgtt tcttgtgtaa gatctcttaa tatataagcc ggccccataa agagaaccaa 743821 aattagagct aagtatgaat tacttataaa accatatatt aaagttaaac ttccatatga 743881 gacagcgcca attaacataa aattaattaa cttattttga aatctctccg acagcttata 743941 tattataaat ccccctatca tcgaacctaa ataatatgct ccattaataa atccccacca 744001 tgattctcct ttatgcaaga cttcgttaac gaaagctaaa gagacagatc ctatccaaat 744061 cattcctgcc catgactcaa ttaaatccat aataataatt gttctaagtt tcttttggct 744121 aaataaatac cgccaaccac ttactatact cttattggga gaattttttt cacgtatgac 744181 agaattagcg tggccatgtg gtagacaaaa taaaagagaa agaagagatg taaacaacaa 744241 aaagatagta agtataatgg tatatccctc acctaaaaat gcaattatga gaccacctaa 744301 agaccagcct acaaattgaa aagtttggtc cactgtagat aataatccat ttgcttttac 744361 tcttctatca ggagagatta tttcccctat aattgcactt tttaaaggtg agaaccatcc 744421 attaaaaaag gaaatacagc taataataat aaagactaaa atgagagttt gattagagta 744481 agttcttaat aaagcataga acaaacatat taataacagc atttgtatca attgagaaat 744541 aattattgta agaggcagtt ttaatcgaat tgttattaac ggtaatatag cacttccaaa 744601 aatacgaaaa ataatactta ttaatgtcac catagaggcg atggttgtcg aattggtcat 744661 tttaaacaaa aacgaaatca ctaccatagt atatagagaa aaacctaaat ttgtagtggt 744721 ctggctaaat aaaatagaat aataaccttt actcatatgt atcctccctt ggaataattt 744781 ttctcggtaa agagcttaaa catatttaaa caccttaaaa caacaaaagt aaagaaaaaa 744841 tttccttgta aactatttac ttttattcta tttattgtta ttgtttattt aagttctctg 744901 actattctat caatattcag ggaaccacat atcttattaa aggggggaaa accatgagaa 744961 aattaagaaa aaactggaga aaatcgattg ttagcccggt tctttatact aatgaaaaat 745021 ggtaaacact tagggaatag catttaatgc tattccttat ttcaacaaac aaatcgggag 745081 gttatcgtaa tttgactcta ttaatgcaag atcataaatc aatttacaat aaagatatag 745141 aaatattaat tgaagttgaa gaacttatta cttctgttcc agaaaataaa aaaaatgatt 745201 ttaagagttt aatcgataat agaattatga ctctactaaa taaaattcaa caccctgtag 745261 cagcggaaaa tgtgtttggg atgtgtattg cttatccgaa tacttacata aggtatagat 745321 taattgattt cgttgaaaaa tgggtacctt atttctctgc tgtagaaact ataatcaatc 745381 taacccagga tccggatgat ttagtttctt ttaaagctat ggatgtctgt gcaaatcata 745441 aaattgaaga atctgtagca tatttgtctt cgattattga tgatgtccgg gagagtataa 745501 gctaccctaa aaaacctgtg ggattagggg cccaaaaagt attaagtaca ttattagata 745561 tattcggtgt tgaaaaacat gaagagctag taatgctaaa aaattatttt gatcaaaatg 745621 gtatacttcc taataacttt gactttgaag aaaaaattcc tcaaagtcta atagaggaat 745681 tcgaaaaaac agaagaagat gggatgattt taattccggg tggctttttt gaattcggtt 745741 taaatgaaaa tgaaattcct gacaaaacat ttaattggaa agatgctgtt cctagacaaa 745801 aagtatggtt acctccattt tttatcgata agtatcctgt tacaaataaa gattatgata 745861 tctttaccga gttcatagag gaaaatgggc atatattctg tcatcctaat gaaccgcaga 745921 ataaacaaca tagaagaaat acatattggg atgataggta tttagataat catcccgtta 745981 caggtataga tttttatgat gcatttgctt acgcaagata taaggggaaa gaattgccaa 746041 ccgagtttca atgggaaaaa gctgctcgag gcgaaaaggg taatgtctgg ccttggggag 746101 ataaatttga tcctgcaaag gttcaatatg ctggaagtct ttataatgaa cccattactt 746161 ctttaaagtc ctggagagaa aatttattaa aagctcatgc tgataaagaa ttaaatcatt 746221 taacaagtga tatttttgaa caaaatggtg aaagtcccta tggagtatgc ggtatgatcg 746281 gcggaacatg ggagtggact agaagtgagc ttaaaacaaa gagagctttc caccctattt 746341 ttgagaatgt accatttaat agtgttaact catttgccgt tcttaaagga ggatcattct 746401 tctctcatcc aggcttaatg ttcccttctt ttagagcaaa agatattcct ttctgtcgac 746461 acaatgaaat ggggattaga tgcgtaaaga atattccagt atataaaatt agagaatcaa 746521 ttaatgggcc aattactaat aaagcaattt attaatcatt ctaggttaga gacttgataa 746581 aagtatacta acattgtgta gtaatgttca gcttgtagaa aaaacaatgt tttttctaca 746641 agattttatt ttaaatgctt ttcaaaatta tcagggattg agaatcagaa aaagagccat 746701 taagctcgat cttagctagg tattacgatc ttctgtatat tattgtgaga aatatagaag 746761 attcagttag ttagcatttc gattttaagc tgagcctgca atagcaaagc atctgttttg 746821 attattcttt ttctgataca taagctaatt ttgtcgcttt tcttttttgt cttttcacgc 746881 atttcgagga tgacttacta taattctttc agcttttcta tgtgttaaga ttcgaataga 746941 tgaaataact ttaacaagtt ggtcaataag aacagattta actttatgtt aaaagagtat 747001 ctcgtataga acataagaag aatgacgagt tttttaagat tatcatcaat tatgtgagaa 747061 taaaatatta taagggaaaa tgaaggctgt cacgtttctc gacagcccta gggaattcct 747121 ctccttttca tttcgcccgt aatttcgggc acagtcccgt cggcaggcac attggcttct 747181 ggtcgatcgg gcttctcatg atgcagcatt ccaagccgaa gacttcacgg aaaaatggct 747241 gggtgaacac atcttccggt gttccggcgt tgtatatttt tccgtccagc acactgatca 747301 gatagtcagc atattgagcg gcttggttta aatcatggag caccatgaca acggtgcggc 747361 catggtcgcg gttcagcttt ttcagcagtt caagcacttc aatctgatgt gagatgtcta 747421 aatacgtggt cggctcatca agcaaaagca aatcagtgcc ttgcgcaagt gccatggaaa 747481 tccaggctct ttgtctttgg ccgcctgaga gggcatcaag tgtccgatcc ttcagttcaa 747541 tcatgcccgt tgcttccagc gcccactcta ccatgtcatg atcctcttgg gtatgcttgg 747601 ataacagctt tttgtgagga tgtctgccaa aatagcataa ttcctctacc gtcaatcctt 747661 caggagcctg aggagattgt ggaagaatgg ccagtttttt tgcgacttct tttgatggct 747721 ggcggtggat gtcttttcct tctagtagca ctgtaccgct ttttggggcc atcagcctgg 747781 cgagcgattt gaggattgtt gatttaccgc agccattagc gccgatgagc gcagtgattt 747841 ttccttcttc tatctttaag tcgactccgt caataatcac tgtactgtca tatgaaagag 747901 tgagctggtc tgcagccagt tttcccatgg tatcctctcc ctactgtttc ctcgcttcga 747961 atttcaataa atataagaaa taaggcgcgc cgatcacggc tgtcagtatt ccggcaggta 748021 tttcaaccgg aggcatgatg ccgcgcccta acgtatctgc aattaataat ataatagcac 748081 caatcaatgc cgatgcaggc agtaaatatt tagctttttc tccggtaagc cgtctggcga 748141 tatgcggagc aagcaagccg ataaaaccga ttgagccgac gacggctaca cagcttcccg 748201 ccagcgccac cgcggtgaaa atcaggatga atctcagccg gtttgcgttt tctccgagac 748261 cctgtgcaag ctcatccccg agtgacataa gatccagctt cggtatgagt atgcagacga 748321 tcggaaaaag aatcaaaagc catggcgcaa gcagcttgac ttcttcccag tttcttcccc 748381 agaggcttcc tgtcagccaa atgagtgcag cattcacgtc gcctggaaac ttgaccatca 748441 tatattgcat tccggcgtgg cagaccgcgc ctaaagcaat gcctgataaa gccagtgaag 748501 agggctgaat gctctttttt cgggctatca ttaataatag tacagcaata atggcggctc 748561 cggcaaatgc ggagaacgga agcacgtata ccggcgactc aggaaagatg agaatcacag 748621 ccatcgccgc aagtccggag ccttttgaaa tgccgacaac gtccggggaa gcgagcggat 748681 ttcggatcac accctgtaaa atcgctccgg cagcggcaag tccagcacct gccaaaatcg 748741 ctaatataat gcggggaagg cgatattgct ggatgataaa ttcaaaggaa tgatccagtc 748801 ccagcagatt cgtcactacc gcatcaggtg aaatgtataa tgcaccgatt ccaatgctga 748861 tgacggacag aacgattaaa atcacggcca atatgagtat cgccagtaag gggcgttttt 748921 gttttctggt tgttttcttc atttcaggtt tcgccctttc cttgccaaat ataagaaaaa 748981 cggcgttccg ataatcgcgg tgacaatgcc gaccggtgat tcataaggaa atgcaatcca 749041 tctggccaga acatctgcgt acaccagcaa aatggcaccg aacagtgccg aaaacggaag 749101 cacgtattga taatgttctc cgatcagctt gcggacaata tgcgggacga gcagcccgac 749161 aaagccaatc ggcccggcga cggctacgga agcgccggaa agaattaaaa taatcaaact 749221 gatcagaatc ctgatgccgt tcatattttg tccaagccct tttgctgttt cgtctccgag 749281 accgagaaca gaaacagaac cggaaaatac gagggcaagc ccgatgccaa tgacagaaaa 749341 aggagcgatg gttatgacgt cctgccagtt gctgccgtcg attgcgcctg tcatccagta 749401 cagaacatcc tcacctgact catttaaaat aatgatggcc tgtgtcatag aggagaggaa 749461 caagtgcacg gccattcctg acagcgccag cttgacaggc gtcattccgc cggatgaggc 749521 aatcatatac acaatcgcgc cgcctgctgc cgcacccgca aaagcgaata taacagatga 749581 atagggcgat gccggcagaa tgacgagaga agcaacaaca aaaagcgatg cacccgcatt 749641 cacaccgaaa atttggggtg aagccagagg atttctggtc atagcctgca tcagcgcccc 749701 tgctacagct aggctggcgc cgacaaaaac gccgattaat gtgcggggaa ggcgaagagt 749761 agagatgatg agctgttcct ttgaaccgtc ccatacaaaa agatatttca atgaatctat 749821 gatgctgatg tctgaggctc ctactgaaag attcagccca agcccaaata taaaaataat 749881 cagtgcaatg ataaacatca tcagtcttga tgatgagcgc cgtttggctg aatgatacaa 749941 cagtctcact tccttactgc gtctggttgc aaaaacgaag aagcaaggat tcccctcgct 750001 tctcatttgt cctatttatt atacactttt ttaagcacat ctttggcgct tgtttcacta 750061 gacttgatgc ctctgaatct tgtccaagtg tcacggtccg catcatagac ttgtccattt 750121 ttcaccgctt tgagattttt ccagagcggg ttcgttttcc actcatctac aatggttttg 750181 ccttcgttgg ctgagatgaa caaaatatca ggatcgattt tgctcaattg ctcaaggctg 750241 acctcttgat aggcgttatc tgacttcaca gcgtgtgtaa agcctagcat tttaaagatt 750301 tctccgtcat aggatgatga tgtatgaagc tggaaggaat ccgctcttgc aacgccgaga 750361 acgatgttgc ggttttcatc tttcggaagt tcggctttta gatcgttgat gacttttttg 750421 tgctcggcaa gcttttcttt tccttcatct tctttattta atgctttagc aatggtcgta 750481 aagctgtcga tcgtttcgtc atatgtcgct tcacggcttt ttaattcaat cgtcggggcg 750541 atttttttca gctgtttata aatgttttta tggcgctcag cgtcagcgat gattaaatca 750601 ggcttcaagg aactgatgac ctcaagattg ggttcgctgc gtgtgcctac agatgtgtaa 750661 tcaatggagc tgccgacaag ctttttaatc atatcttttt tgttgtcatc tgcgatgccc 750721 accggcgtaa tgccgagatt gtgaacggca tccaagaatg aaagctcaag cacaaccacc 750781 cgcttaggtg tgccgcttac tgtcgttttt ccttcttcgt catggatcac tctggaatcc 750841 ttagactcgc ttttgccgct tccgttgtta ttctggcttg atgaacagcc ggatacaatg 750901 aggcaggcga gcaataaaac actcatgatg gcaatcaact tgttagaata ggtgcgcatg 750961 tcattcttcc ttttttcaga tttagtaatg agaatcatta tcacatgtaa cactataata 751021 gcatggctta tcatgtcaat atttttttag taaagaaagc tgcgttttta ctgctttctc 751081 atgaaagcat catcagacac aaataagtgg tatgcagcgt taccgtgtct tcgagacaaa 751141 aacgcatggg cgttggcttt agaggtttcg aacatatcag cagtgacata aggaaggaga 751201 gtgctgagat aaccggacaa tttcttttct atttcatctg ttagtgcaaa ttcaatgtcg 751261 ccgatattca tgataatcga gaaaacaaag tcgatatcga tatgaaaatg ttcctcggca 751321 aaaaccgcaa gctcgtgaat tcctggtgaa catccggcac gcttatggaa aatctgtttg 751381 actaaatcac tcacaatcca agcattgtat tgctgttctg gtgaaaagta ttgcattaga 751441 catacctcct gctcgtacgg ataaaggcag cgtttcatgg tcgtgtgctc cgtgcagcgg 751501 cttctcctta attttgattt ttctgaaaat aggtcccgtt cctatcactt taccatggac 751561 ggaaaacaaa tagctactac cattcctcct gtttttctct tcaatgttct ggaatctgtt 751621 tcaggtacag acgatcgggt atgaaagaaa tatagaaaac atgaaggagg aatatcgaca 751681 tgaaaccagt tgtaaaagag tatacaaatg acgaacagct catgaaagat gtagaggaat 751741 tgcagaaaat gggtgttgcg aaagaggatg tatacgtctt agctcacgac gatgacagaa 751801 cggaacgcct ggctgacaac acgaacgcca acacgatcgg agccaaagaa acaggtttca 751861 agcacgcggt gggaaatatc ttcaataaaa aaggagacga gctccgcaat aaaattcacg 751921 aaatcggttt ttctgaagat gaagccgctc aatttgaaaa acgcttagat gaaggaaaag 751981 tgcttctctt tgtgacagat aacgaaaaag tgaaagcttg ggcataaagc aaggaaaaaa 752041 ccaaaaggcc aatgtcggcc ttttggtttt tttgcggtct ttgcggtggg attttgcaga 752101 atgccgcaat aggatagcgg aacattttcg gttctgaatg tccctcaatt tgctattata 752161 tttttgtgat aaattggaat aaaatctcac aaaatagaaa atgggggtac atagtggatg 752221 aaaaaagtga tgttagctac ggctttgttt ttaggattga ctccagctgg cgcgaacgca 752281 gctgatttag gccaccagac gttgggatcc aatgatggct ggggcgcgta ctcgaccggc 752341 acgacaggcg gatcaaaagc atcctcctca aatgtgtata ccgtcagcaa cagaaaccag 752401 cttgtctcgg cattagggaa ggaaacgaac acaacgccaa aaatcattta tatcaaggga 752461 acgattgaca tgaacgtgga tgacaatctg aagccgcttg gcctaaatga ctataaagat 752521 ccggagtatg atttggacaa atatttgaaa gcctatgatc ctagcacatg gggcaaaaaa 752581 gagccgtcgg gaacacaaga agaagcgaga gcacgctctc agaaaaacca aaaagcacgg 752641 gtcatggtgg atatccctgc aaacacgacg atcgtcggtt cagggactaa cgctaaagtc 752701 gtgggaggaa acttccaaat caagagtgat aacgtcatta ttcgcaacat tgaattccag 752761 gatgcctatg actattttcc gcaatgggat ccgactgacg gaagctcagg gaactggaac 752821 tcacaatacg acaacatcac gataaacggc ggcacacaca tctggattga tcactgtaca 752881 tttaatgacg gttcgcgtcc ggacagcaca tcaccgaaat attatggaag aaaatatcag 752941 caccatgacg gccaaacgga tgcttccaac ggtgctaact atatcacgat gtcctacaac 753001 tattatcacg atcatgataa aagctccatt ttcggatcaa gtgacagcaa aacctccgat 753061 gacggcaaat taaaaattac gctgcatcat aaccgctata aaaatattgt ccagcgcgcg 753121 ccgagagtcc gcttcgggca agtgcacgta tacaacaact attatgaagg aagcacaagc 753181 tcttcaagtt atccttttag ctatgcatgg ggaatcggaa agtcatctaa aatctatgcc 753241 caaaacaatg tcattgacgt accgggactg tcagctgcta aaacgatcag cgtattcagc 753301 gggggaacgg ctttatatga ctccggcacg ttgctgaacg gcacacagat caacgcatcg 753361 gctgcaaacg ggctgagctc ttctgtcggc tggacgccgt ctctgcatgg atcgattgat 753421 gcttctgcta atgtgaaatc aaatgttata aatcaagcgg gtgcgggtaa attaaattaa 753481 gaaagtgaaa aacacaaagg gtgctaacct ttgtgttttt taattaatta aaatgtttat 753541 taacttagtt aaggagtaga atggaaaagg ggatcggaaa acaagtatat aggaggagac 753601 ctatttatgg cttcagaaaa agacgcagga aaacagtcag cagtaaagct tgttccattg 753661 cttattactg tcgctgtggg actaatcatc tggtttattc ccgctccgtc cggacttgaa 753721 cctaaagctt ggcatttgtt tgcgattttt gtcgcaacaa ttatcggctt tatctccaag 753781 cccttgccaa tgggtgcaat tgcaattttt gcattggcgg ttactgcact aactggaaca 753841 ctatcaattg aggatacatt aagcggattc gggaataaga ccatttggct tatcgttatc 753901 gcattcttta tttcccgggg atttatcaaa accggtctcg gtgcgagaat ttcgtatgta 753961 ttcgttcaga aattcggaaa aaaaaccctt ggactttctt attcactgct attcagtgat 754021 ttaatacttt cacctgctat tccaagtaat acggcgcgtg caggaggcat tatatttcct 754081 attatcagat cattatccga aacattcgga tcaagcccgg caaatggaac agagagaaaa 754141 atcggtgcat tcttattaaa aaccggtttt caggggaatc tgatcacatc tgctatgttc 754201 ctgacagcga tggcggcgaa cccgctgatt gccaagctgg cccatgatgt cgcaggggtg 754261 gacttaacat ggacaagctg ggcaattgcc gcgattgtac cgggacttgt aagcttaatc 754321 atcacgccgc ttgtgattta caaactgtat ccgccggaaa tcaaagaaac accggatgcg 754381 gcgaaaatcg caacagaaaa actgaaagaa atgggaccgt tcaaaaaatc ggagctttcc 754441 atggttatcg tgtttctttt ggtgcttgtg ctgtggattt ttggcggcag cttcaacatc 754501 gacgctacca caaccgcatt gatcggtttg gccgttctct tattatcaca agttctgact 754561 tgggatgata tcaagaaaga acagggcgct tgggatacgc tcacttggtt tgcggcgctt 754621 gtcatgctcg ccaacttctt gaatgaatta ggcatggtgt cttggttcag taatgccatg 754681 aaatcatccg tatcagggtt ctcttggatt gtggcattca tcattttaat tgttgtgtat 754741 tattactctc actatttctt tgcaagtgcg acagcccaca tcagtgcgat gtattcagca 754801 tttttggctg tcgtcgtggc agcgggcgca ccgccgcttt tagcagcgct gagcctcgcg 754861 ttcatcagca acctgttcgg gtcaacgact cactacggtt ctggagcggc tccggtcttc 754921 ttcggagcag gctacatccc gcaaggcaaa tggtggtcca tcggatttat cctgtcgatt 754981 gttcatatca tcgtatggct tgtgatcggc ggattatggt ggaaagtact aggaatatgg 755041 tagaaagaaa aaggcagacg cggtctgcct ttttttattt tcactccttc gtaagaaaat 755101 ggattttgaa aaatgagaaa attccctgtg aaaaatggta tgatctaggt agaaaggacg 755161 gctggtgctg tggtgaaaaa gcggttccat ttttccctgc aaacaaaaat aatggggctg 755221 attgcggctc tgctggtctt tgtcattggt gtgctgacca ttacgttagc cgttcagcat 755281 acacagggag aacggagaca ggcagagcag ctggcggttc aaacggcgag aaccatttcc 755341 tatatgccgc cggttaaaga gctcattgag agaaaagacg gacatgcggc tcagacgcaa 755401 gaggtcattg aacaaatgaa agaacagact ggtgcgtttg ccatttatgt tttgaacgaa 755461 aaaggagaca ttcgcagcgc ctctggaaaa agcggattaa agaaactgga gcgcagcaga 755521 gaaattttgt ttggcggttc gcatgtttct gaaacaaaag cggatggacg aagagtgatc 755581 agagggagcg cgccgattat aaaagaacag aagggataca gccaagtgat cggcagcgtg 755641 tctgttgatt ttctgcaaac ggagacagag caaagcatca aaaagcattt gagaaatttg 755701 agtgtgattg ctgtgcttgt actgctgctc ggatttattg gcgccgccgt gctggcgaaa 755761 agcatcagaa aggatacgct cgggcttgaa ccgcatgaga tcgcggctct atatcgtgag 755821 aggaacgcaa tgcttttcgc gattcgagaa gggattattg ccaccaatcg tgaaggcgtc 755881 gtcaccatga tgaacgtatc ggcggccgag atgctgaagc tgcccgagcc tgtgatccat 755941 cttcctatag atgacgtcat gccgggagca gggctgatgt ctgtgcttga aaaaggagaa 756001 atgctgccga accaggaagt aagcgtcaac gatcaagtgt ttattatcaa tacgaaagtg 756061 atgaatcaag gcgggcaggc gtatgggatt gtcgtcagct tcagggagaa aacagagctg 756121 aagaagctga tcgacacatt gacagaggtt cgcaaatatt cagaggatct cagggcgcag 756181 actcatgaat tttcaaataa gctttatgcg attttagggc tgcttgagct tggggagtat 756241 gatgaagcca ttgatctgat taaagaggaa tatgcgatac aaaatgaaca gcatgatctt 756301 ttattccata acatccattc gcagcaggtg caggccattt tgttagggaa aataagcaag 756361 gcatcggaaa agaaggtcaa gctggtgatt gatgagaaca gctcactcgc gcctcttcct 756421 gcgcatatcg gcttgtccca tcttattacg attattggca atttaattga taacgctttc 756481 gaagctgtag cggagcaaag cgtgaaggaa gttttgtttt ttatcacgga tatgggccat 756541 gacattgtca ttgaagtatc agacacaggg cccggtgtgc cgccagagaa aatagaagct 756601 gtgtttgaga gaggctattc ttcaaagggg atgaggagag gctacggtct ggccaatgtg 756661 aaagactcag tgcgtgaact gggcggctgg atcgaactgg cgaatcaaaa aactggcggg 756721 gcggtattca ctgtatttat accgaaggag aaacaaaggg ggaatccatt tgattcacat 756781 cgcgattgcg gaggatgatt ttcgagttgc gcaaatccat gagagattga ttaaacagct 756841 tgatggattc aagattatcg gcaaggcggc taacgcaaaa gagacattgg cgcttttgaa 756901 ggaacacaag gctgatttgc ttctgctgga tatttatatg ccggacgagc ttgggaccgc 756961 gttgattcct gatatacgaa gccgatttcc tgaagtggac attatgatta tcacagcggc 757021 aacagaaacc cgtcatttgc aggaagcgct aagggcggga attgcccact atttgatcaa 757081 acccgtaaca gctgacaagt tcaggcaggt gctgcttcag tataaagaaa aaaggaagct 757141 gctcatgtct cagccggagg tcagccaatc catgatcgac catatttttg ggaacggtgt 757201 gaagacagct ttgccggcag aggatttgcc gactggcatt aattcgatta cactgcgaaa 757261 aattaaggaa gcgcttcaga ctgcgtcaga aggattgaca gcggaggaac ttggggaaaa 757321 aatgggggcg tcacgaacaa ctgcccgccg ttatgccgag taccttgtgt caaaggaaga 757381 agcaagagcc gagcttgaat acgggattat cggcaggccg gagagaaaat attatttggc 757441 ggcggattag atatgaaaaa atctataatc ctattgaata ttctattgat ctttatgcag 757501 ggtgatatca ggcaggcggc tgcgccgcgc ctgccggacg ggccgataga aattgtcgtc 757561 cctgccgaac cttctggcgg ctgggatgtc acagcgcagg cgatccaatc agttttgagg 757621 cagaagcaga tcgtgaagga tgatgttcat atcgtctata aatccggcgg cgggggagag 757681 aaaggctgga aatatgtcaa caaaagcagc aaacaaacca tcagcatgac gtccagccta 757741 atattgagca atgatcttct cgggcaaagc aaattaaaaa tgtccgattt tacgccgctc 757801 gccattctct ccaaggaatg gcagacggtt gcattgccaa aaggatcagc gttaacaaat 757861 ggcaaggatg tgctgaatga gatcaacatg catcccggca aggtgagaat cggctttgcc 757921 ccggggtttg gcaatgatga tcagctctcg ttcgtcagag cggcagatat gtacggcatt 757981 gacccgtttg acattcaatt ctcacagtat gacagcagcg aacagctcat tcaggcgctg 758041 atcagacatg agatagaagc ggcttccatg acactttctg aagcgaaacc atatgaacga 758101 aacggcgata tcacgttagc cgctgtaacg tctgataaaa gacttcccgg ttttccaaat 758161 gtaccgacgt ggaaggagca gggaatcccg tttgtttttt ctcattggag agggattttg 758221 ggcccgaaaa atatgtctga ggaagagatt tcttactggg atcaagcgct aaagaaggtc 758281 acctcctcac ctgaatggaa gcggaaaata aacgaacagg actgggaaag cttttattta 758341 aacagcaggg aaacgaaacg gtttttagaa gagcaatctg ctttttatca aagcatcatg 758401 acaggaaatt aaaatcccga catcccggga tttttttcat gccgaaaatt gatcaaaaag 758461 aacaaaacgg ttttaaaaaa ttaaaaatac aaaaaaacca aattatttac ttgcggttgg 758521 ttttcccata cgatggcaaa aaggcaagac aaaaagggga gtaagggaga aaaaaatgta 758581 agcggattca tttaaggggg aatggatgtg ttagcaatct taggctttct catgatgctt 758641 gtgtttatgg cattgatcat gacaaaacgg ctttctgttt taacagcatt agttttgacg 758701 ccgattgtgt ttgcgcttat cgccggattt ggatttactg aagttgggga catgatgatt 758761 tcggggattc agcaagtcgc gccgactgcg gtcatgatta tgtttgcgat cttatatttt 758821 ggaattatga ttgatacagg cctgtttgat ccaatggttg gcaaaatttt aagcatggtc 758881 aaaggagacc ctttaaaaat tgttgtcggg acagcggttc ttacaatgct cgtcgccttg 758941 gacggagatg gctcgacaac gtacatgatt acgacaagcg ccatgcttcc gctctatttg 759001 ctgctaggca tccggccaat tatcttggca ggaatcgcgg gagtcggcat gggaatcatg 759061 aacacgattc catggggagg tgcgacgccg agggcggcga gtgcgctggg ggttgatcca 759121 gctgagctta cagggccgat gattcctgtc attgcaagcg ggatgctttg tatggtggca 759181 gttgcgtatg tgcttggaaa agcggaacga aagcgccttg gtgtgattga actgaaacag 759241 ccagccaatg ccaatgaacc ggctgctgcg gttgaagatg agtggaagcg gccgaagctt 759301 tggtggttca atttattgtt aacgctttct ttaataggat gtttagtatc gggtaaagtc 759361 agtttaaccg tactgtttgt cattgcgttt tgtattgcgc tgattgtgaa ttatcccaat 759421 ctcgagcatc agagacagcg catcgcggcg cattccagca acgtgctggc tatcggttca 759481 atgatttttg ctgcgggggt gttcacgggg attttgacag gcacgaaaat ggttgatgaa 759541 atggcgatct cgctcgtgtc catgataccg gaacaaatgg gcggattgat cccggcgatt 759601 gttgccttaa caagcggcat tttcacattt ttgatgccga atgacgcgta tttctacggg 759661 gtgctgccga ttttatcaga aacagctgtc gcatacggtg tggataaagt ggaaattgcc 759721 agagcctcta ttatcggcca gccgattcat atgctgagtc cgcttgtgcc atccactcat 759781 ttgcttgtcg gactcgtcgg agtttctatt gatgaccatc aaaaattcgc attgaaatgg 759841 gcggttctcg cagtgatcgt catgacggct atcgctctat tgatcggtgc gatctctatt 759901 tccgtatgat aattcaggcg taatgacaca cactaacggc atacaacatt ccggaggtgt 759961 cattatgagt gatccttata tgccgctgac ttcagtcaga agcggagcgg ggttcgaagc 760021 ggcaaaaggg gtgcacggcc tgactgtgca aattgcgaat gtctatttta ttcagctgcc 760081 ttctgaacct cactcatttg ttttaattga tgccggcatg ccccaatcag ccggcgtgat 760141 tgtcaatgaa gccaaacaaa gattcggtga agggtttcag ctgaaggcga ttatcctcac 760201 acacgggcac tttgaccata ttggggcaat cgaagagatc cttgagcatt gggatgtgcc 760261 tgtttatatc cattctcggg aaatgcctta tgtaacaggt aaagaggatt atcctccggc 760321 tcgtcctgac agcaagagcg ggctggtcgc taagctgtcg ccgctgtttc cgcggcactc 760381 tatcgatatt tcctcacatg tccaggcact gccggaagac ggttcagttc cttttcttga 760441 cgagtggatg tggatcgcga caccaggaca cacgccgggc catatttcgt tattccgcga 760501 tgacggccgc gtgcttgtgg caggtgatgc tgttattaca gtggaacagg agaaaatggc 760561 tgacgtcttg atacaaaaac aggagcttca cgggccgccg gcttatttca cgcctgacac 760621 agagacggcc gctgagtcca ttctaaagct ggccggtctt gaaccggaag cgttattgac 760681 cgggcacggc ataccgatga ccggcaaaaa ctttcgaagt gacttaactg aattggcaaa 760741 tcggttatcg tctatttgac acccgcacca cgcgggtgtt ttttattgtt ttccaggaag 760801 ttgcagaaaa atcatttgtc ttgccgctta aaaacgatac aatgaaaagc atgaagtgat 760861 gtgaagggga gagtttgttg gaagaaaaag aaatactctg gaacgaagcg aaagcgttta 760921 ttgccgcatg ctatcaggaa ttgggaaagg aggaggaagt gaaagaccgt ctcgcggaca 760981 ttaaaagtga aattgacctg accggaagct atgtacatac gaaggaagag ctggagcacg 761041 gagcgaaaat ggcttggaga aacagcaacc gctgcatcgg cagattgttc tggaattcgc 761101 tgaatgttat cgacagacga gacgtccgga cgaaggagga agtgcgtgat gccctctttc 761161 accatattga aaccgccacc aataacggga aaatcagacc gaccattacg attttccctc 761221 cggaagagaa gggtgaaaag caagtcgaga tctggaatca tcagctgatc cggtacgctg 761281 gatatgagtc agacggagaa agaatcggcg acccggcttc ctgttccctg acagcagcct 761341 gcgaagagct cggctggcgc ggagagcgaa cggattttga cctgctgccg ctcatttttc 761401 gcatgaaagg ggacgagcag cctgtctggt atgagctgcc gcgttcactt gtgattgagg 761461 ttccaatcac acatccggac atcgaggcgt tttctgattt ggagctgaag tggtacggcg 761521 tgcctattat ttctgatatg aagcttgagg tcgggggcat tcattataat gccgcgccat 761581 ttaacggctg gtatatgggc acggagatcg gagcgagaaa cctcgcagat gaaaagcggt 761641 acgacaagct caaaaaagta gcgtccgtga tcggcatcgc cgctgattac aatacggatt 761701 tatggaagga tcaagcgcta gttgaattga ataaagctgt gctgcactcg tataaaaagc 761761 agggtgtcag catcgttgac catcatacag cggcaagcca gtttaaacgg tttgaagaac 761821 aggaggaaga agcgggcaga aagctgacgg gggactggac gtggctgatt ccgccaattt 761881 cacccgctgc cactcatatc ttccaccgct cctatgataa ctcaatcgtt aagccgaact 761941 atttttatca agataagcct tatgagtaaa caatagaaaa tcgatgatgg ccttcaaggc 762001 tgcgggattc agtcacagag atgtcggtaa cctttgagaa agggcttccg ttctttacag 762061 cctcaacaaa cgattgcagg gcgttttccg gaccctctgc caaaatctcg acacgcccgt 762121 catcacggtt tttgacccag ccggccagtt ttcgcttatc agcttccatt tgaacaaaat 762181 agcgaaagcc cacaccttga acccggccgt ctacaatgat tcggtattga agcatgtaaa 762241 aaccaccttt tctttttatg ataatcaatc attttacaac ctgtaaaggg gatgtgtttg 762301 tatgaaacaa gagcgctatt cagttctttc tcttaatctg ggaaaaccgc agacgcttga 762361 atatgacgga aagaaaatcg aaaccggcat catgaagcgg ccggctaaat cagccgtcat 762421 gctgtatcgg gagaattttg aaggagacgg acaggcggac ctcgtcaacc acggcggacc 762481 tgataaggct gtctgtgtct acccggcgga gcattatccg ttttgggaag agttcctctc 762541 aagaccgctg tcaaatgccg catttggaga aaatctgacg gtcgcgggcc tgactgagga 762601 gaatgtttgc atcggggatg tgttcagact tgatgaagct gttgttcagg tcagccagcc 762661 gcgccagccg tgtgtaaagc tggcgaaaaa gtttggtgta aaagaaatgg tgctgaaggt 762721 ccagcaaacc ggctatacag ggttttattt tcgcgtgctg gaggagggca gggtgtctcc 762781 cggcgcgaac cttgaattgc tgtccagagg agagaaaggc atatccgtcc agttcgcgaa 762841 ccgcatcaac taccatgatg caaaaaatct caccgccatt gaacggattt taagtgaggc 762901 tgcactatcg gaaagctgga gagcgtcctt tatgaaaaaa aaggacaggc tgctgccggt 762961 tgaatagaaa aaagccgcgc atatcaacgt gcgcggcttt gccatattta agattgtttt 763021 ttctttgatt caagcaggtt ggcaagaaaa taggttttat agctttgaag ctttcttcct 763081 tcatggtgcg tgatcccctg cttttttagt tctgccacat accagccttt actgccgtaa 763141 tgcatgtcag aaaactcctt tccctatctg atttcgaaac gattggcatt gtaacatcta 763201 taaaaagatg ctgaaaagag atgcggggaa aactgagcct ttcgcactag atgtacgaat 763261 gttcttctga atgtatatgc ggagcaaaag ccgaatatga tttaatggcc ggttagtttg 763321 atcatgacaa cgccaaatgt cataatggcg aaaacaatgc cgatatatgt gagcatcccg 763381 ttttttttct taacgccgta aacggtcata atgatgcctt caatgaaaaa aatgatgccg 763441 aaaataataa accacatgca gataaaggct cctttcacag acataatagt agtgtagcat 763501 atctgaaaga gccgggctgt gacaatatca agaaagccgg gcgcatatcg cccggctcat 763561 gttttattgt ttatcaacca atttgaccag aagctgtgcc aaatgttctt tctcatcttc 763621 gtctgcaacg ctccaaagct cttgcagcag catttcttca ccgttttgcg gctcttcatg 763681 ctttgcgagg tagtctccca ggatcgcagc gctttttaca agcttgccgt catccaatcc 763741 cagctttttg cctcggttga cttgtttttt caggtagcct ttaaattcct caaagtcttt 763801 taaaatgtct tcttttattg tgccatgcat cgcgttcatt tcgttttcaa tttggatttt 763861 ttcttgatct ctgttcattg caagacctcc tcgtacagaa taatgatgct ttacctgcaa 763921 ttggaggagg ttaaacctgc cggaagcccg gaatgtgttt tacagtttcg tcaggataat 763981 cggttcatct tttgtgatga cgatcgtgtg ttcaacttgg gcaaccatgc ttttatccgg 764041 cgtcttgaac gtccagccgt ctccagcttc aacaatcgtt tctgctttcg ttgaaataaa 764101 cggttcaagc gcgatgactg tgccattttt gaacagcgca ttatcaaacg gatcataata 764161 gttcatgatg tggttcggcg cttcatgcag gcttcggccg attccgtggc cggtcagggt 764221 tttgatgacg gtaaagcctt gagagcgtgc ttcatgataa acggctcttc cgatctggtt 764281 ttggcgcttg cccgcttttg cctgctgaag ccccttttga aaagcgtttt ccgcgcattg 764341 gcaaagctta tgaaggcgtt cttctccttc accgagcaca aatgagatgc ctgtgtcgga 764401 atagaagccg ccaaattcag cggagatgtc gatgttgaca aggtcccctg cttttaaaat 764461 tttggatgtg cttggtatgc cgtgagccac ttcatcattt acgctgatac atgtcacacc 764521 tggaaaatcg tattccttct caggagctga aacggcgccg tgctcatcaa gcacagcttt 764581 tccgataagg tcaaggtctt ttgtgctcat gccgggctct gccttccgct tcatttcttc 764641 acgcgcaagc gcgacgattc ttccgatttt tttcaggcct tctaattctt gatcgtttgt 764701 tacaatcatc tgtcattccc gctttctttt taaataatct agattaagct taccacaact 764761 gtcttaaaaa taggaaacac acggacctgg gaaaaaagaa atacccccgg gaaaattggt 764821 atagatcact agatatctta tatggtatat ttgaaaaaaa agggtatgag ggggatgggt 764881 atgctttcat ttttacaaaa actcgggaag tcatttatgc tcccgattgc ggttctgcct 764941 gcggttggaa ttatccttgc gcttggcaga gaggatgtat ttaatatccc gtttgtctat 765001 caggcgggga cggcggtttt tgatcatctg ccgcttattt ttgcgatcgg tattgccatc 765061 ggcatttcaa aagacagcaa tggggcagcg ggtttatcag gggcgatatc gtatctgatg 765121 cttgacgcgg caacaaagac aattgataaa acaaataaca tggcggtgtt tgggggaatt 765181 attgccggtt taattgccgg ttacacctat aaccgcttca aggataccaa gctgcctgaa 765241 tatctcgggt tcttcagtgg cagacggctt gtgccgattt taacagccat tattacgatc 765301 attttagcgg gcatattcgg agtggtctgg ccgccgattc aatcgtgtat caactcgttt 765361 ggagagtgga tgctcgggct cggcggcatc ggggcaggca tattcggcct attcaacagg 765421 ctgttaattc cgcttggcct tcaccatgtg ctgaacaata ttttctggtt ccaattcgga 765481 gaatataacg gagtgacagg ggatttggcg cgctttttcg cgaaagatcc gactgcgggc 765541 acatatatga ccggattttt cccaatcatg atgttcggtc ttccggcggc gtgtctggct 765601 atggttgtga ctgcgaagcc gtctaaacgg aaagcgacgg ctggaatgat gattggattt 765661 gctttaacgg cgtttatcac agggattacg gagccgattg agtttgcatt tatgttttta 765721 tctccgcttt tatacgctgt tcacgcggtc ttaaccgggt tatctttatt tatcgtcaac 765781 tggctcggca tccgctcagg cttctctttt tcagccggag ctatcgatta tgtgctcagc 765841 tatggaatcg cggaaaaacc gctgcttctg cttttggtag gtatatgcta tgcggcagta 765901 tactttatcg tgttttatgt actgattaag gctttgaatt taaaaacgcc tggacgggaa 765961 gacgatgatg tggatgaagt gctggatgaa aatactgttc aggatgtaaa tgaaaacatc 766021 atgctgaaag ggctcggcgg aaaagaaaac cttcaaacca ttgatcattg cgccacaagg 766081 ctgcgactga ctgtgaagga taccgctttg gtggatgaag cactgctaaa gaaagcaggc 766141 gcaaaagggg ttgtcaaatc gggcgggcaa tcggttcaag tcattattgg cccgaatgtg 766201 gaatttgcag ctgaggaatt gagggctgct gtcaaataaa aaagcggaga gggcaacctc 766261 tccgcttttt cttatttatc ttcgttatcc tttgacgttt cggaagaatc ttcgtcatgt 766321 tttgtgtaat cataatcaga aggattcacc ttcttaaaac ctttcggctc gtagaaccgc 766381 agcaggtctc cgtttatgat tttatcggac atttcaagtt ccttcttgac gagtgagtct 766441 tctgacttgt cgacttcgga ttcatcgagt tcttttccgg ttttcgtgtc gtaatactta 766501 ccggatattt tcgtgtactt cggtgaaata aagtctccgt ttcggaacgg aatcacttca 766561 cggtgttctt tcgataaaat atcagaaccg gacatcagat agtccttcgt atccactccg 766621 agcagatgca gaatggtagg agccacatca acgtctccgg catatttatg aactttctcg 766681 cccttcacgc cggcagcgtg gataaagagc ggcacccgtt gaagctgggc gttgtcgtaa 766741 tcagtgattt catccttgcc aagcactttc gccatcgctt tattgtggtt ttcagagatg 766801 ccgtagtggt ctccgtacat cacaataatc gatttatcat ataacccgtc ttttttcaga 766861 tcattgaaga attgttcaat ggactgatca aggtaatggg ctgactggaa atagttatcg 766921 acgacagagt caccaaagtc tccagccggg aagtctgtat ccccctcatc cattccgaat 766981 gggaagtggt tggaaagggt aatgaacttc gtatagaacg gctgcggcag gctttccagc 767041 agcggcattg attctttgaa gaacggtttg tctttcatgc cgtagttttt cgtgttttct 767101 tcgttcatgt catagtaagc agaatcaaag aatttatcaa tgccttccgc cttgtacatt 767161 tcgttacggt tccagaacgt ctgcgtgttc ccgtggaaag tagcagatgt gtaattctta 767221 gacttcagaa tcgccggaac ggattgcagc gtgttttgcg ctttgtttac gaaaactgaa 767281 ccttgagcca gcgggtacag agagttttcc atcataaatt cagcatcaga tgttttacct 767341 tgtcccgttt ggtggaaaaa gttatcaaag tagaacgttt cgttatcatg tgccagttta 767401 tttaagaatg gtgtcacttc tttgccgtca attttatagt cgatgataaa tgactgcaaa 767461 gattcaagtg aaacgtaaat gacgtttttt ccttccgctt tgccgaaata cacgttattc 767521 ggcacatcgt aattggcttt catgtagttt tctacttccg ttacgtcgct ggaatcggca 767581 agcgcgcgct ggctgttgga cttgatattc tgtacagcgt cataaatcgt gaaattgtat 767641 gttcccaagt atttcacaag atagttccgg tcgaatgatc ttgtcagcaa ttcaggacgg 767701 tctgattccg caactgccag gttgatcaag aacacaagaa ttgaagacgc aaaaataatt 767761 cggaacgatt ttttgcttga cgtttcggca ggcttgttta ctttgatcgc caagatgatc 767821 aggatgatcg tatcgataaa gtaaaaggcg tcagtcggtc tcatcagcga aaatgcgctg 767881 tcaccgagtt ggccgccgtt tgttttagcc tgcataatga ccggaattgt aataaaatca 767941 ttgaaaaatc tgtagtacac aatgttggcg tacagtaaaa aagacattaa aaaatgaatc 768001 actataatgg ctgtctgctg taattttttc ttgaacaaga gtccaaagcc aagaaagaac 768061 aagcttgagc taagaggatt cacaaaaagc aatatttttt gtatcgtgtt gtctattcct 768121 aagttgaaat tcaggacata accgacatac gttttgatcc ataacaggac gaccgcaatt 768181 aagaagaagg ccagtcctct ttcttttata aatgttttca ttgttacact ccttttttcc 768241 gatccagttc gagcgaaacg atagaaaaaa cgaacgtatc caatataaca cgaatcagca 768301 gattagaaaa gtgaaaatcg tatgagggag aaagtggcga aaaacgccgt cgaatcaacg 768361 tttcgctttg atattaccaa atgtaaaaca aggtatcttt ctagaaataa aggaataaaa 768421 tggtacattg agaattgtat gataaaatat aaggtataga taaaaagagg tgaaatgatg 768481 gatttttccc atattgtgtc tgaagataaa attaagcgcg ccatcaaaga cggggacttt 768541 caaaacctcc cgggaatggg gaagccgctg ccgaaggatg acgcggcaca cttgccggaa 768601 tcgctgcgca tgggctatcg tattttgaaa aacgcgggaa tggcagagga cgagggcgcg 768661 ctcaaaaaag agcttatgac catcgaccat ttaatcgaaa agtgctatga cgaaaaagaa 768721 cgcgagcaat taatcagaaa aaaatctgaa aagcaattgc tgcttgataa gcttgtcgac 768781 aaaaaaggca tgttttcaaa gccagcatcc gctttttata agaataaagt atatgaccgg 768841 cttggacgaa acagaccttc ttccagctga tttgtcttgt ctgcaggatg gcgattgata 768901 aaagccatcc tttttatgtt ccaagttcta tgtcaaaagg tttatgtttt tccatctatg 768961 ggaaatgatt cataaacgaa aaaagggtga tgggatggaa cgactattag tatggataga 769021 gcatatatct gattggctgt ggggtccgcc gctaatcatc ctgctgacgg ggacgggctt 769081 gtatttcact attttgctga aaggttttca atttcgctat cctttataca ttttcaaaca 769141 gacaatcggc agtgtaggaa aaaagccgaa gggagaaggc acagtcacac cgcttcaggc 769201 attgacctca gccctcagtt caacgatcgg tgcagcgaac attgtcggtg tgcccgccgc 769261 tattatgttt gggggaccag gagcggtttt ttggatgtgg cttattgcct tatttgccat 769321 ggcgattaag ttttctgaaa gtgttcttgc tgttcattac agagaaaaaa atgagcaggg 769381 tgaatacgtc gggggaccga tgtattacat aacaaaaggg ctgcgcatga aatggctcgg 769441 cgtattcttc tctgttgcgc tgattgtgga gctgattccc agcattatgg ttcagggaaa 769501 ttcggtttca gtctcgcttg ccgagacgtt ttctttcaat aaaatatacg caggaatcgg 769561 aattgcattt ttgattgggt tagtggtgat aggaggggta aagcggatcg gaaaagtaac 769621 agagtttgtc gtgcctctta tggcaggggc atacgcaggt gccggtctcc tgattgttct 769681 catgaatcta tcatcagtgc cggcgttttt ctctctcgtt ttttcaaatg cgtttacctc 769741 ttcttcagca gttggagggt tcgcaggtgc tgcgttggcg gaaaccgttc gctggggatt 769801 tgcccgcggg ctgtattcta atgaagccgg gatgggaaca gccccgattg cacatgcggc 769861 agcaatgact gatcatcctg tgcggcaagg gttttggtct gtgatcggca ttgtcattga 769921 caccttaatc atctgtacga ctaccgcttt tatcgtcctt gcatccggtg tatggacagg 769981 gaagaacgcc tcaaatgacc cggcagcact gacaacggcc gcatttcagc actatttcgg 770041 ttctggagga ggatacttcg tttcggtttc cctggtcttc tttgtcgtat caaccattat 770101 ggttgtcatt ttttacggcg taaagcaagc tgaatttctg ttcgggcggc tggcaggaca 770161 tgtgattaaa ttcgtttatt tagcggctat tatcataggt gccgcaggcg gagcaaaagc 770221 catttggggc gtattggact tagcattggt ttttattgtt gtcccgaatg tgattgcgct 770281 cttgttattg agcagaaagg taaaagcgct gtacaccgaa ttctttacat ctgaacagta 770341 ctacctgaaa gatataagaa aaacgaaaca aaagcctgtt tatccaacaa aagaagctaa 770401 aaattcctag tgttttgctt ttgcgccgaa caatgctttg ctttttatga tcaaataaat 770461 gagtaaaggc agcaaaagag aaatcactac attaatgatt ggtttgattc tgttaaagtc 770521 gattagctga tttgtattta aaaaaaacca aaagccgcat acgactgaga acatgccggt 770581 tggtgtatac atggctttcg ggtcgatttt tgagtgtaaa aacgaaaggc cgtataccac 770641 gatatatagg gaacctgcta tcttcaccat aatgaccgga atccaaaaag ccgcgatgat 770701 caggtctgag cgatccagaa aatccgtaat gcggatctgc ctgatgacca tataagcagg 770761 atcaaagaaa gtagatgtca ggttgggacc aaagacagaa attgaagaaa ataacatcac 770821 ggccagcaat aaagcgccca gcagtatcgc gaaaatggtg tattttagcg ggacgctccg 770881 gtttgagaag agaagcggaa ggataatcaa ttcccccatt gtcccaaacg cgtaatagcc 770941 tgattgaagg tatgggatta gaccttcaaa aacaggtgtc aagttttgaa gctcaatttg 771001 tgtggccagc gtaaatggaa ggaacaagac caggatgccg aatggaaata ggaatatctg 771061 cgccattctg gtcaatgttt cttttccctc tctggcaata cagatcgcca caaagataat 771121 aacaccgcca agaacagcca ttggtgttct cgggagaaat aaaatgttaa tcaaattgat 771181 gaaaaaacgt atatcatgag cattgattaa caggaaatac aaagaaaaca gtaaaatgat 771241 aatccggcct gcgattggtg aggaatcgct cagcagctca tagatatttt tatcctgatg 771301 ctttttcatc agcctatgca tgagccagag tgccggaatc acgatgacaa cgccgaggat 771361 gtagctgtgc caggcatttt gttttgctga ttcgatcatg agaatcggag catgctttaa 771421 tccgactgct aacgtataca gagctccgaa aaataatcct tggtatgcag aggtcttgtc 771481 cataaagcac atcctttctg tcatgttcaa aacggaatat atttaaacag gtgccccagc 771541 cgcggaagca ggggattcac tctcatataa atccatagaa aagcacttcc tgcaattagc 771601 aggctgaagg cccattttgt tagattgtta gcggaacgaa aattcttcca ttcatatgcg 771661 tatatggcaa tgcacacaat caatgtctgt acgatatagc tgatcatgct gacgcacctc 771721 cattaatggc tgatcgtttt gtataggaca ccgccctgct caatcgtcac aattgggacg 771781 acgtgaacct ccatatcctt atatacctct tcccattcct ttttcagcag attcttcgtg 771841 gttgccgtgc ttctgatggt cctgtcttga aagccggccg ggtccgcctt tagcttttgc 771901 aaacgatgaa cggtgctgat cacgtccttc tttatggttc tgtttaatgc tttttgaatg 771961 atgtaatact ggtcattttc tctcgtctca taggttgatt ggttttccat aataattcct 772021 ttggctctga tctcgattgt cattgacagc tttccgtttt tttcagcggc atgaaaggat 772081 gcattggact tttgaagctg aatggatgct tgccccattt gattcggcag gtctactatg 772141 aattctggct ggcgggcttg attcagcaac atcagggctg ctgtcatgtg ttcatctttg 772201 aaaatatcca tcaatctgtc ctttttaaag atcgcaagcc cgtcaatttt caaattagat 772261 ttgcctttcc ctccaggttt tgttttagat gcagagatga ccggtgcata cggatcactg 772321 cctatttcta ctagatcaga catgaatctg cttaagaaaa cggggcggct cgttgcgata 772381 atggccagct cccgaatcat ttccgccgga aactgttcaa gctgaacatc ggtatttaaa 772441 atgtcccgcg cttctccccg gctgactaaa atgagcgccg ttaatctgtt ctgcggattt 772501 cgcgttaaaa tatcaaagac tggggcaacg ccgtctctcg ccatatcctc tccaataatg 772561 actgtacgtc tgtgggacgt attgattgtc cgtgacaagg aggtttgcag cttgttgttc 772621 gcttctctga tcgtagtgcc ggaagctgaa tcaacatacc atgtttttga accggcagtt 772681 ccgccgccgc cccctgtttg tccgcctaat tggccgacca agggaatctg catggccact 772741 cgatactgat cttttttctt atcaatggct gagctgacaa caaatgcaat gtcattgatt 772801 tctgtccggt cccagcaccc cgttagaagg atacaaatga gaagcggcaa aacacactta 772861 tatattgttt tcttcatctt ttgggtcctc tcttttcgct cccttctgtc cgttgccgcg 772921 cgaatacgtg cccggccttc tggtcatcgt ccaccaaggc gccctgacaa aaatatcttt 772981 tacttcatct cgtttaaacg gagaaatccc ggataaataa ggaatgccga aagattgcag 773041 cttgcataaa tgaagcacta agataatcgt gccgagcata atgccgaata tcccaaaaat 773101 actcgccaaa aacataagcg ggaaacgaag catcctgatg gagatagcta agttaaaccg 773161 cggaattgta aatgacgcga tccctgttaa cgatacgatg atcaccatgg gggcagacac 773221 aattcccgct tcaacagcgg ctgtcccaat gactagggcc ccgagaatac tgacggtctg 773281 gccgatggtt ttcggcaggc gcactcccgc ctcacggaga gcctcaaaag aaatttccat 773341 aatcaatgct tctatgatgg cggggaaagg aatcggttca cgcgcagagg ccacactgaa 773401 cattaagttt gtcggcatta agtcctggtg gtatgtaata acggcaacat aaatagccgg 773461 caaatataaa gcaacgaata aaaacatata gcgaagccag cggattaagt tagacatcaa 773521 ataacgctca tagtaatctt cactggcctg cataagctgc caaaacgtaa tcgggcctgt 773581 taagacaaag ggcgtattat ctgtgaaaat ggcaaatcgg ccttcgagaa gctgggcggc 773641 gacggtgtcc ggcctttctg tgtattgcag ctgggggaat ggcgagtacg tgtcgtcttc 773701 gataaattct tcaatatatc cgctttctaa gacagcatca atctttatct ttttgattct 773761 tttttttgct ttgtcaataa cctttggatc ggcaagcccg tcaatatagg ccaagacaac 773821 atcggttttg gttttcgtgc cgattttaaa agagatcatt ttaagctgaa acgttttgac 773881 gcgaaagcgc acaagagcgg tattgaccct gaggctttca gtgaagccct ctcttgaccc 773941 tctgatggtc gattctgtta tcggctcttc aatgcttctt ctttgtccgc cttttatatt 774001 taagatcagg ccttttgagt gcccgtcggc aaataaaacc gcgttcccct caatgatgga 774061 tgcagccact ttgctcatac tcgtttctaa tgcaacactt gaaattgata gagtattttg 774121 cagcgcctct tcatgttcat ctatttgatc cgtcaaatgc attaagaaag ggcggagggc 774181 gtgatcctga atatgttcag attttacaat tccttcgata taaacaataa atccgcacag 774241 cccgtttcca aagtcaaatt gtctaaatac gatgtctgag cagccttctg ttaataaggt 774301 cagattttcg aggttttcct tcaaattggg agagatcggt ctgtcctgat tgtcttcaag 774361 ctctttgatg agctgaagcg ctttgtcgcg tttattcata gaggctcacc ctgcttttta 774421 atgtcatatt caataagtgc ttgtgacttt tagggtaacc ttgtctgttt catatattcc 774481 agactaggat gaaagcgcta taaaaaagtg ttgactacct gtatatacag gaatacaata 774541 tgattataag ttgtatatac aagttataaa aacggatacg gaggggttgg catgggggaa 774601 ctgaacaaat cggcacgtca gattgtcgaa gcagtcggcg gtgctgaaaa tattgcagcg 774661 gcaactcatt gtgttacacg tttgcgtttt gctttaatag atgaaagcaa ggttgaccaa 774721 gagatgcttg atcaaattga tgtggtaaag ggatcattct cgacaaacgg acagtttcag 774781 gtcgtaatcg gccagggaac tgtcaataaa gtatatgctg aactggttaa ggaaacgggg 774841 attggcgagt caacaaagga tgaagtgaag aaggcctcag aaaaaaatat gaatcctttg 774901 cagcgtgctg tgaaaacgct tgcagatatt tttattccaa tattgcctgc gattgtcacg 774961 gcgggtcttt taatggggat caataacatt ttaacggcgg aaggcatttt cttcagcaca 775021 aaatcgattg tgcaggttta tccgcagtgg gcggatcttg ctaatatgat taacctgatt 775081 gcaggcacgg cctttacgtt tttgcctgcg ttaatcggat ggtctgccgt caagcggttc 775141 ggcggcaatc cgcttctcgg cattgtgctc ggggttatgc tcgtgcatcc tgatttgctg 775201 aatgcgtggg gatatggcgc ggcagaacaa agcggagaga tcccggtatg gaatctattc 775261 ggcctagagg tgcagaaagt cggctatcag ggccaggtgc tcccaatttt gcttgcttct 775321 tatatgctgg cgaagattga ggtattttta acaaaacgca cacctgaggg catacagctg 775381 ctcgttgtcg caccaattac gcttctctta acaggatttg cctcttttat cattatcggc 775441 ccgattacat ttgcgatcgg taatgtactg acttcagggc ttatctcggt gtttggttct 775501 tttgccgcac tgggcggtct gttatatggc ggtttctact cagcgctcgt gattaccggt 775561 atgcatcaca cgtttcttgc agtcgacctg cagctcatcg gttcaaagct cggcggcacc 775621 tttttatggc cgatgctggc gctttctaat atcgcacaag gttcggcggc tctggccatg 775681 atgtttatcg tgaaggatga gaaacaaaaa ggcctctccc tcacatcagg gatttctgct 775741 tatcttggca ttacagagcc tgccatcttt ggggtgaatc tgcgatacag attcccgttt 775801 atcattgcaa tggtcagctc tggcctggcc ggaatgtata tttcttctca aggtgtgctg 775861 gcaagctccg tcggtgtcgg cggcgtgccg gggattttct caatcatgag ccagtactgg 775921 ggcgcgtttg caatcgggat ggctattgta ttgatcgtgc cgtttgccgg aacatacgcg 775981 tatgcgagat tcaaacataa ataacaagtg gggagcggga cgtgttgaac gttccctttt 776041 cccgttttca atttaaatat ggtggtggaa acagatgaaa acagaacaaa cgccatggtg 776101 gaaaaaagct gtggtttatc aaatttatcc gaaaagcttt aacgatacga caggaaatgg 776161 tgttggcgat ctgaacggca ttattgaaaa gctggattac ttaaaaacgc tacaggtgga 776221 tgtgctttgg ctgacgccga tttatgattc tccccagcat gataatgggt acgatattcg 776281 tgattattac tcgatttatc ctgaatacgg aacgatggag gattttgagc ggctagtgtc 776341 cgaagcacat aaaagagacc tgaaagtcgt catggatctt gttgtcaatc atacgtcaac 776401 agagcacaaa tggtttcgcg aggcgatctc ttcaatagac agcccgtacc gtgattttta 776461 tatatggaaa aaaccgcagg aaaacggttc tgttccgacg aactgggaat cgaaattcgg 776521 cggctcggca tgggagcttg acgaagcatc gggccaatac tatttgcatc tgtttgatgt 776581 gacgcaggct gatttgaatt gggaaaatga agaggtcaga aagcatgtct atgacatgat 776641 gcatttttgg tttgaaaagg gaatagacgg ctttaggctt gatgtcatca acctgatttc 776701 taaagatcag cgctttccga atgcggagga aggcgacggc cgctcttttt acactgacgg 776761 gccgcgggtg cacgaatttc tgcatgaaat gaacgaaaag gtgttttcac attacgacag 776821 catgacggtc ggtgagatgt cttcaacaac cgtagaccac tgcatccggt atacgaatcc 776881 tgacaataaa gaacttgata tgacattcag cttccatcat ctcaaggttg actatcctaa 776941 cggcgaaaaa tgggccttgg cgccgtttga ttttttgaag ctgaaggaga tcctatctga 777001 ctggcaaacg gggatgcacg caggaggggg atggaacgct ctgttctggt gcaatcatga 777061 tcagccgcgc gtcgtatcaa gatatggaga tgatggcgca tatagggtga aatcggcgaa 777121 aatgcttgct acggccattc atatgatgca gggcacgcct tatatttatc agggcgagga 777181 gctggggatg acgaatccga agttcactga cataagctcc tatcgggatg tcgaatcgct 777241 gaacatgtat cacgccttta aggaaaaagg aatggctgat caagatatta cagccatttt 777301 acaggcgaaa tcccgtgaca attccagaac ccccgttcag tgggatgcta cggaaaatgg 777361 tggttttaca acgggcacac catggatacc ggttgcagga aattaccggg aaatcaatgc 777421 tgaagcggcg ctgagggatc agaattcggt gttttaccat tatcaaaaat tgattcagat 777481 tcgcaaaatg tatgacattg tgacagaggg tacgtatgag ataattgcaa aggatgaccc 777541 gaacattttt gcgtatctca gacacggcag caatgaaaag ctgctcgtga tcaataattt 777601 ttacgggaca gaggcggcct ttacactgcc ggactcttta gcgcctgacg aatggaaggc 777661 agaggtgctg ttgacgaacg atgaagcaag ggaagggctt cagaacatga cgcttcgccc 777721 atatgagtcc attgtttatc gtttaacgaa accgtgttaa actaagctgg gtggtccata 777781 atgaaggtga ataaattcat cacaatttat aaagacatcg cacagcaaat tgaaggcggc 777841 cgatggaaag cggaggagat tcttccgtct gaacatgagt tgaccgcaca gtacggtaca 777901 tcaagagaaa cggtccgaaa ggcgcttcat atgctcgcgc aaaacggtta tatccagaaa 777961 atcaggggaa aaggctccgt cgtgctcaat cgtgaaaaaa tgcagtttcc cgtttcgggc 778021 cttgtcagct tcaaggagct cgcgcaaacg cttggcaaag aaacgaaaac aactgtacac 778081 aaattcgggc tggagcctcc gtcagagctg atccaaaaac agctccgggc caatctggat 778141 gacgacatct gggaagtcat caggtctaga aagattgacg gggaacatgt gattttggac 778201 aaggattact ttttcagaaa gcatgtccct cacctgacga aagaaatttg tgaaaactcc 778261 atatatgaat atatagaagg agagctcggt ctttcgatca gttacgccca aaaagaaatt 778321 gtagccgagc cgtgtacgga cgaggacaga gagctgctcg atttacgcgg ctatgaccat 778381 atggtcgtgg tgagaaacta cgtctttttg gaggatacca gtttgtttca atatacggaa 778441 agcagacacc gtctcgacaa attccgattt gttgattttg cgcggcgggg gaaatgagag 778501 aggcgcctgc ctgcggcagc gcgctttttt gtttggtatc aaaattgata ctatccaaca 778561 aaaatgtgcg tacttttact ttttatcata atggctacaa tagagatgag agtaatctaa 778621 aggagaggtg ttttacatgg cagatctaaa gacacaaatt ctggatgcat acaatttcag 778681 gcatgcgact aaggaatttg acccgaataa aaaagtgtca gacagcgatt ttgaatttat 778741 tttagaaaca ggaagactgt ctccgagctc actcggcctt gagccttgga aatttgtcgt 778801 cgtccaaaat ccggaattcc gcgagaagct tcgtgaatac acatggggcg cgcaaaagca 778861 gctgccgacc gcaagccatt tcgtcctgat tcttgcgcgt acagcgaagg atatcaaata 778921 taatgcggac tacatcaaac gtcatttaaa agaagtaaaa caaatgcctc aagacgtgta 778981 cgaaggctat ttaagcaaaa cagaagaatt ccagaaaaac gatttgcatt tgcttgaaag 779041 tgacagaaca ttgtttgact gggcatcaaa acaaacctat atcgcgcttg gcaacatgat 779101 gactgccgct gcgcaaatcg gtgttgattc ctgcccgatc gaaggcttcc agtacgatca 779161 cattcaccgt attcttgaag aagaaggcct tctggaaaac ggaagcttcg atatttctgt 779221 gatggtggca ttcggctacc gagtgagaga ccctcgtccg aaaacaagat ctgctgttga 779281 agatgttgtg aagtgggttt aaaagaagaa agctgctcgc atagcgagca gctctttttt 779341 atgcctgatt cgctctattc tgttttctcc tctgatgtaa gtacattgcc gttccgagtg 779401 cgctgatcag aaatccggcc aacaggatcg agtacatgga tgtggctgtg tccggaagca 779461 ggccgccagc cggaccgtct gttcctgatc cgcccgaacc gtttccacca gagccgttag 779521 tcggttgagt gccgggaggc gtatcatttc ctccgtttcc gtcagttggc tgttttccgc 779581 ctggtttgtc ggagcctccg ccatgattgc cgtcatcacc gcctgtcggt tgatctgacg 779641 ggaatgccgg cggtttgttg tttgaaccgg aatttaagat cgtgtattcg ctgaagtggt 779701 ttgtatatcc tgtcaccata tcatcatcga ctgatccgtg acctgtcttt gtgaaagctt 779761 tcttttttct atcgacgtga taaatggcag ggttatgggc ttcttcaata tcaaacatgc 779821 gaagcgaaag ctgtacgggc tccttgaatg attttatttc ttttcctttt tgcttcactg 779881 taaagtcata tacatctgac agtgacacat ccaattctcc cgtagacttg attccgattg 779941 cagtgtctgc ggttttaagg ttcgccattg gcatcttcat gctgtaccag tagttgaaca 780001 tcgtcaatga aggatctgac tctctttctt tcaaaagttt gacctgatct tttttcactt 780061 taagattgat aggcttctct tgagatcctt catgtattcc ataatagaca aatggcgtgt 780121 tggcattttt agcataaatc gcaaatttgt cttcatcaag tgtccagctg ccgtccttct 780181 gctttgtcgg caggaatact tctttgattc gtccttcaac tttaggagag accttgtttc 780241 ctagtttttt cagctgttcg gtgaaaatct cataatcaac gtagccaagg tcttcaccat 780301 gggaggcttc tgtaaagaca gaatatccgt ctcctccggc accgacaaaa ttatttgttg 780361 ccacgcggta ggtatcatcc gtatttatag caactttgtc tccgttaggc gattcaattt 780421 tcacttctaa cacacggtgt ccaggtttgt tgtttaatgt aaaggtatat tcgattccgg 780481 ccacctgagg gaaagcgccg ccgccatttt ccacattgct taggccttgt tcaagggctt 780541 ctttaatttg ttttccggtt aaatcggcca cgtaaagcgt attgccgaac ggcatcacgt 780601 tgagcacctc gccgagtgtg atatcacctt tgtcaatgcc tgctctgatg ccgccgccat 780661 ttgttatcgc tattctggcg ccggctgctt ctttcgcttt tgccagcata ccgtccgcga 780721 tgaagtttcc gagattcgtt tctttcgtgc gcacatgctc acgctggccg tcaagcgcca 780781 catccgtgta gccgactttt tcatttttca cgtcctctaa ttcatttttg aactgatcga 780841 gctcttgttt tgcttctggg ttttcttctg tatgttcatc aattggcagc acgctcagat 780901 ttgatttatc tgtttgcaca acgccttttt catcaaacgc gacatcaacg cgccccaaga 780961 attggccgta ttcttttgcc tgcgccacga tcgtcggttc ttcgttgttc acgacctcca 781021 ttttgtctac gagggtgtga gtgtgtccgc cgatgatcaa atcaatgcct tttacttttt 781081 tggctagctc aagatcccgg ttatgtccga tgtgggttaa agcaataatt ttatttacct 781141 tttcttcttc ttgaatcgct ttgacggtgt tttgtgctgt ttcaaaggca tcattgaata 781201 cgatgctttt gcccgggctt gatgtggtgg ctgtatcttc tgttgtcagg ccgaatacgg 781261 cgactttctc cccgtcaacg tctaacagaa tgtaagggtg aatgccggcc tctttctttt 781321 cacctgccgt aaaggtttgc ggctttttga caaatgattt cagcttgggc tcatttgaca 781381 catctacgtt tgcactgaca atcggaaatt ccggcgcttc aaagtgatag cggttcgccg 781441 gatcaacggt tgcgctgttt ccgcttagaa aatcagaaag caccgtcggg cctttgtcaa 781501 attcatggtt tccgaaggtc atggcgtcat agcccatcat gttcatcatt ttcagatcgg 781561 ccaaaccgtt ccatttagta aaatacagat cgccggaaaa cacatctccc gcatcaagga 781621 gaatattgtg atttgtttcg ctgcgtactt cgttgatttt cgtcattcgt ctcgctgcat 781681 catcgagatg ggcgtgcgta tcattggtgt gcatgacggt cagatcccac agtccgtctt 781741 taggaggatc tggatttgaa tcatcatcga attgcagctt atacacacca tagccttcat 781801 tcgcagactt gcctacataa gcgacatcgt ctgctttatc ggcaaatggc ttggccaaaa 781861 gcgaggattc aaacgtcaga ttcgtgccgg aaacaggcgc gattgaccag ttgttgtctg 781921 cttttggatt gactgttttt tgttcaataa tgtaatccat cagcacctgc ctattttcaa 781981 ctgcagagcc gtggacaatt ttatcgctcg tcagatgagg gaacccgccg cctccggacg 782041 cacgatagtt attggtgact acgagaaatt cctggcttgg gctgatcggc ttgccttcat 782101 aggaaagatt gatgatacgg gatgaatccg cattgatcac ttttccgttc tcattgtatt 782161 tagccggttt tgtcacatcg acctgatatg tgacaccgtc aatcacgtca aaattatagg 782221 agcggaaatt ctcgttcagc aaggcctggt cgccgccttt agctggatca atttgattga 782281 attggcctgc tgacatctcc agccagtcct tgacctcgct gcctgtcagc ttgacgattt 782341 gaacagtatt atcgtaaaga tacaagtcac cgacattttt aatcgcaaga tctccggctg 782401 gaatgtttgt atagtaattg gctccgtttc tgccgcctgc tttaaacggc gctccagcgg 782461 ataaaatcgg caggttcttg tactcggtat ccttcatttc tttttcagcg taccactttt 782521 gcgcgtcagt cacgatctga atggaaggat catctttgac ctgtgcaaag aagctgttaa 782581 tatctgcttc ggttttgccg actggctttc ggacatactc cagtgtgttt tggtgtgttt 782641 gctgaatggt gtttgtaacg gtttcgtttc ttgatgtgac gttgccagca atagattcaa 782701 tacttccttt ggaatctgct accttccatg agccgtccgc cttttcaagc ttgaggtcaa 782761 tcacgcctaa atatttgccc cagctgcttg gcatgacgac aggaatgccg ttaattgttc 782821 ccttttccac attgaactga gcaacacccg catactcggc ggaaggaaag agtccgtgct 782881 gatggcccga gataatcgcg tcaatgcctt tcgttttggt ggcaaggtca aacacggcgt 782941 tttctgcgcc tgatgattgc gcctgctttt caatgccggt gtgggcgagg gcaataatga 783001 catctgcgcc ttccgccttc attttcggga tcgtttcatt ggcggattct acgatatcct 783061 gcacctgaac ttgcccctcg agattctttt tgtcccatgt catgatttgc ggcgggacaa 783121 agcctatgta gccgactttt actttctgct cattaccgtt ttcatcaatg agggtttttt 783181 cattaatcac atacggcgta taacggtttt cgccgctagt tgttttgacg ttggcattta 783241 caatcgggaa atcggctcct ttgattgtgc cgtcgagaaa gtcgagcccg tagttgaatt 783301 catgattgcc aagcgttccg gcgtcgtatt tcagcgcatt catgacgctg ataatcggat 783361 gggttttcgt gccggagata atgtcgtctt tttgatattt caccgcgtat tcacccagcg 783421 gattcccttg aatcaagtcg ccgttatcca caagcagggt gttagggttt tgctcgcggt 783481 gcttttggat caattgcgct gttctcgcca gaccgaaatc cgccgtttct ttgtcgctgt 783541 agtaatcgta atccatcatg ttggcatgaa tatcagtcgt agccaaaata ctcagatgca 783601 cctgaggagc cgcgctttct tctgcatgaa tgggtggtgt tgggaggatt aggctaagta 783661 tcataattgg gggcaaaaga atacggagaa tgttttcgac gtgtgttcgt cttttctgta 783721 ttctcaccag ttctccacct ttcaacgaaa tttgtgttac agctcctatt gtaagaatat 783781 tttgtaacta tttgtaggtg tttctttatg attattgtaa aagggagaaa aatgagtatt 783841 atgtagcagt atcaaacgac aaatactggg catttatgct tatcgtttgt cacaatcgcg 783901 gaatgtttat tttagtgtgg ctggggtaga gtgttttatg tagacatata aagcgggagg 783961 ttatgaatca tggggaaaaa aattgcagtt gttttaacat attattttga ggacagcgag 784021 tacactgagc ctgcgaaagc ctttaaagaa gcgggacatg aactgactgt catcgaaaaa 784081 gaaaaaggaa aaacagtaaa aggcaagcag ggaacagcgg aagtgacggt tgacgcgtcc 784141 attgacgacg taaattcttc agactttgat gcgcttttga ttcctggagg attttcacca 784201 gaccagcttc gcgctgacga tcgtttcgtc caatttacaa aagcgtttat gactgacaaa 784261 aagccggtat ttgccatttg ccacggcccg cagcttttaa tcaatgcgaa agcgctcgac 784321 ggccgaaaag cgacgggcta tacgtccatt cgtgttgaca tggaaaacgc cggtgccgac 784381 gttgtggaca aggaagtggt tgtttgccag gatcaattgg tcactagccg cacaccggac 784441 gatataccgg catttaaccg cgagtcattg gcattgcttg agaaataaga aaaaacggac 784501 gctcttgggc gtccgttttt ttgttgctta ggcttgagca cctgtcagtt tcttgtacct 784561 gtaatacaag aaagcagctg cagccgttcc gatgaccgca atgccgaagt cgaatatgaa 784621 aatatgggcg atgccccccg cttttgcgat aagccctgtt gcaatcggca gcagaatcga 784681 tgcaagactt gaagcagtcg ctacaattcc ggtaacggtt ccttttcgct tccagaaaag 784741 ctctgtcatt aacgtaatgg taatttgaaa cacacccgca gttgaaaagc ctaagaaaaa 784801 ggcagtgatg tccagcacaa ctgggatatg aacggtcagc atgactgcga gcgtacataa 784861 agtaataata ggatataaga gcgttatgaa gacaggtttg acccatctat tcagcaaaac 784921 ggctaataat aaaacagatg ccagagatcc tatactataa tagctcagca attgtacaga 784981 tgctgattca gctaaaccgg ctgccttttg cgcgtagctc gggagccaga tttgagaaac 785041 cgtaaataaa gccgtggatg taaaaccgat gataatcagt gcggtgcctt ccttctgaaa 785101 aacgggttca gacaagaaaa cgggagattc ctgttggccg ctattagttg gtttcttatg 785161 ttttttagga aacgaaagcg ttgataaata aataatattc aggagataga ccgctgccgg 785221 cagataaaaa gcaaatccgt aaaacatgct gtggtctgct aaaaatgtga tcaaaagcgg 785281 caaaagtgcg gcccccacag acataaaggc tttaaccaag acatttgccg aaccggaagc 785341 agacggaaag agctcggtta gggccggata tgttccggca tccatggctg aattagcgac 785401 tccggctaat aaagcgaaca caaacgccag ctcatagctc ggtgataaag gaataccgac 785461 taaaaagacg gccataattc ccgcagaagc gacaacaagc ggctttctgc cgattttatc 785521 tgatagaacg ccggaaatgc cgtatgtcag cagtttgcca aacccgatag cggcaatgac 785581 ataactgatg ccggtcggat cggtattcca ctgttttgtt aatgaagaca tattggatgc 785641 gagaatgatg ttgaccatcc ccagaaagaa gtagttgata tacattccgg atgctgtttt 785701 gatagatgtc gtttgcatgc ttgtactcct tcaaatctta ttcgaacact ttgctgtttt 785761 ggtttgggga aatgataaaa aagactcgcc gagtttccgg ccagtctcca ttatttacga 785821 agcgaggcta attcttgagc aatcgcctgc atttcacttg ggctgaatga ttcttttttc 785881 atcaccattc tgtgaaggta cgtgaggtct tcaatcttct catcactgaa atcctccgct 785941 ttgattacgc cgacgttcag catgttcagc ttttgggaaa tctcttcaat catttgagtt 786001 aatgtttctg tatttgggct ggacaaaggg ttccatcctt tctatgcgca atataggtat 786061 gttttattct aacagaattc catcagaaaa aaaccctatt ctaaaagcag gctgttcatt 786121 ccaaaaaagt gaagacatca gttgaaaaga aaatgaacat cctactaaga tattcatgaa 786181 ggtttctttt tagagaaata ggggcaaaga atagggaggt tgcacatcat gataagcgtg 786241 ttatttgttt gtttaggtaa catttgccgg tctccgatgg cggaagcgat ttttagggac 786301 ctggcagcca aaaaaggatt agaggggaaa atcaaggcgg actcagccgg tattggcggc 786361 tggcacatcg gcaacccccc gcatgaggga acgcaggaga tattgcgcag agaaggaatc 786421 agctttgatg gcatgctggc gcgtcaagtc agcgaacagg atctggacga ttttgattac 786481 atcattgcaa tggatgcaga aaatatcgga agtctcagaa gcatggcggg ttttaaaaac 786541 acctcgcata tcaaaaggct cttggactat gttgaagatt cagatctggc tgacgtaccc 786601 gatccttact acacagggaa ctttgaagag gtctgccaat taatcaaaac gggctgtgag 786661 cagttgcttg catccattca aaaagaaaaa caattgtgag tgaaaggaga atttgcatga 786721 acaacgaacg tttaatgctg aaagggatat ttctcggagc tgcggcaggc gcggcgttat 786781 cactgctcca taagccgaca agacaggcgt gcgggatgag atggctgaca tgcaagcata 786841 aactttcact gtacaaaagc aacccagagc tgttaaaaaa cactgtcatc acaaaagtgg 786901 atgaggccaa aaagctcgcc cgaacgcttt caaaggaagt cgactttgtg aaccagcagg 786961 tgaaagagct gaagaaaaca acgccgcaag tgatggaact cgtgcaagaa acgaaagagc 787021 atttttcaaa aaaatgatca aacatgcgag gtgagacgac atgagttttt tgaaagagct 787081 tttcagcaga tacacccttc atgaaggaca aagtaaatca gcggagctgg cgtatttttt 787141 tctattgtca ctgtttccgt ttttgatttt tatgctgacg ctcaccgcgt atcttccgct 787201 ttctaccgat gatgttttag gagtcataga acaatatgct cccgccagtg cgatgtcact 787261 cgttgaatcc attacccatc aaaccttaaa taatcgaaat ggcggtttgc tgtcattcgg 787321 gattatcgcc gcattatggt ctgcgtctaa tggaatgaat gcgatcgtcc ggtcgctgaa 787381 ccacgcgtat gatgtggaag aaaaccgctc ttttatcatt gttcgtctaa cctcgatttt 787441 tttgacgatt gccatggtat ttacgatttt agtggctttg cttctgccgg tatttggccg 787501 ggagattgga aggctcgctt ctgactttgt cggcgcgtcg gatctgtttt tatccgtctg 787561 ggccgccatt cgctggggtg tcagcccgct tgtgcttttg attgtttttt ccgcgctgta 787621 tgtgattgcg ccgaacaaaa agctgtctct ccggtttgtc atgccgggtg cggtctttgc 787681 gactatcggc tggatcattg tcagcacatt gttttcattt tacgtcagca cgtttgcgaa 787741 ctatagcgcc acttacggga gcatcggggg aatcatcgtt ctgatgattt ggttttactt 787801 gagcggcatt ttaattatcc taggcggaga aatcaacgct cttttacata aacgtaaaaa 787861 gcttcctgat gaaaatccct accattagcg caccctataa acgaacttcg gttcaaaaag 787921 aagtcggggg gatatcgtga tgaccaagca tacgaaaaaa ggcggaagcc ataacaaaca 787981 aaactcgaaa agcaaatcga gccataaaac aagcggaagc gccaacggac aaaacggcta 788041 ccattagcat aaaagcctcc tgacatgatg tcgggaggct ttttgattaa gaagatgaag 788101 aataggtttc agccggtgac cagcttttcg gtttgcccag cacaagggcc agccacacag 788161 agctaagcgt gagagtaatg aagtagaaca agtttgcgct ttcaaatgtc tgcatatacc 788221 agccgccggc aactgggccg aggatgctac cgagactgaa tgtaatgccg caaagcaggt 788281 ttcccgccgg caggaggtga ggcggaagaa ggtctgtcat atagctgatg ccaagtgtaa 788341 aggttgatcc gactgccatt cctgcaataa aaaagcagcc gccgatcacg tagggcgaag 788401 gaaatacacc ggcgatgaaa aagcaaagag ccccagtcag taaaatcacc agcagcacat 788461 tccgcctgcc gtatttatcg ctgaggatgc cgagcggaaa ctgaaagata atgcttccaa 788521 tcgcaaatgc gggaaggatg atcgctactg cgtctactga tatccccaaa cggagcgcgt 788581 acaccggaaa gcttccgttc agcgccgttt ccagaaagcc atagccaaat gtaggcataa 788641 aggcaaccca cccaaacagc atggcctgat aaaatcgcct gaaactattg tctgatttgg 788701 tttcatgagg actggtttcc gggtatgcat tttgtagaaa gaaaacaaaa agccacgcaa 788761 acagactgat gcagccggac acgataaaag gaagcgacgg actcagcttg acaagcggca 788821 ccatgaacgg gcctgcggca aagccaaggc caaaggaaag cccataaata gacaggtttc 788881 ttccgcgatt ttgttttgat gacatggagg tcacccacgt ttgcgtagaa aagtgaagca 788941 tgtggtcgcc gattccaatg aacaggcgaa gcaggaacca gacccaaact gactgaagcc 789001 aaataaatcc gaataagctt aaaatgacaa tgcttccgcc catgacgatc agcggcttga 789061 acccgagctt tctgagcggt gcttccataa acggcgaagc caaaagcaca ccgatataca 789121 gcccggtcgc gtgcaggccg ttgatagcag cggattctcc atttgtttca aaaatgattg 789181 aaatgacagg cagcagcatg ccttgtgaaa acccggaaat ggaaacgagc aagacaagga 789241 taaagaaatg aaatcgtgac atcgtgtcag ttctccttat atggaatcta tgttgatcgt 789301 acaacgtttt ccaaaagcag gcaacctgaa aaaagcctat atcacgctat acatttgccc 789361 tcgtgtaatc atgaaggttt ttgtgaagaa taaaaataaa acaagtcata aaaaaggagc 789421 tatttcacca tgaatcgtat cttttttatt ttagtggcgg ccggtgttcc gctttctgtg 789481 attggcagtt tgatgcattg gccttccgcg gttctatttg cagtttattg cgtgacgatt 789541 atcgcgcttg caagctatat ggggagggcg acagaatcac tgtccatcat tgcaggaccg 789601 cgtatcggcg gtttgttgaa tgcaaccttc gggaatgcgg tggagctgat tatttccctt 789661 tttgcattaa aagaaggcct gacaggaatc gtgcttgcct ctttaaccgg ttcagtgctg 789721 gggaacctgt tgctggtagc gggcctatcg ttttttgtcg gcggtttaaa atataagcgg 789781 caggaattta atatccatga tgcccgccat aactccgggc ttctgatttt tgccatcatt 789841 gtcgcctttg tgattccgga ggtattctct gttggtatgg gaaacgccag caagctcaat 789901 ttaagcatcg gcatcagcat cattatgatt ctgttatatg tggcggcgct gtactttaaa 789961 cttgtcacgc atcggggcgt ttatcagccg aataatgccg ctcagactga agaagaggaa 790021 gagccagaat ggtcagggaa ggttgcgacg attgtcttgt ttgcggcaac gattgtggtt 790081 gcatacatat ccgaaaacct ggtccatacc tttcactcgg tggctgaaca gttcgggtgg 790141 agcgagctgt ttattggggt catcatcgtg gcgattgtag gaaatgcggc ggagcatgcg 790201 tcagcgatta ttatggcctt caaaaataaa atggacattg ctgttgaaat tgcagtaggc 790261 tctacgctgc agatcgctat gtttgtcgca ccggttctcg tcatctgttc tatctttttt 790321 ccgacaagca tgccgcttgt atttacattg cctgagctcg tcgcgatggt atcagcggtt 790381 ctcttgatga tcgcgatttc gaatgacggg gattccaact ggtttgaagg ggcgacactg 790441 cttgctgcat atgtcattat ggcgatcggc tttttccttc tttaacctga aaaaatgatg 790501 gataacaaca aagcgggatg aaaagactaa gggaaaatgc catagaaaga gtgatatgat 790561 gaaaaagcta tttcattcca cacttattgt gttgttattc tttagttttt tcggcgttca 790621 gcccatccac gcgaaaaagc agtttaaggt tcctaattct gtcgcaagca tttcaaagga 790681 aaacacgtat ccgaatgctt cacaggatca gccaatgctt cagccgagca agctggcaaa 790741 ggaattgctc gatcattctg aggtaaagat tgaaaatccg catctcatca aaatgctgaa 790801 tgaatccaac atatccggca caccgcttgc agtagggtac cgggcgacaa tatttctcgg 790861 gaaatgggcg ctcggctatg aatcaaatga aacagtcgca aactgggaat ataaaaaaat 790921 caatacaaac cgtgcggata accgcggcgg gaaagaaacg gctgaaatgc attatgccca 790981 ggaacagcag tacagagtga agggcggctt gacagctaaa gttccaaatg ctgaagatgt 791041 caaaagcatg atgatgcaaa aagcaatgaa gaaaacgaac ctcccgcttg catttgagac 791101 ggtcatcggg gctggcacaa aacgggatca gatttataaa gtcgctccta aaaaaatcgg 791161 ttatctacat gcatatgcac cggctgtgaa tgaaaaagga aaagtgactt acggagaagt 791221 gtacttagtg ctgaaaggaa ataaacgaaa actcgtcgtg aaaaatgtca cgtcacaggg 791281 aatcggcgcg tggattccgg ttcaagatca tgtcacgttt ggctttcagc tttcctcact 791341 gccaagataa ataaaaaact gattccaact cggaatcagt ttttttgttt attgggttct 791401 ctcgattcgg accgcttcct caagcatttg cacattgttt tggtagagct ggcgaacgag 791461 aacccgtctt actgcaaggc tggcactgaa ataatcatca tctttcacca tgcctttaac 791521 cgtaaattcg acgccgcgat tgattttatt caatgcggtg atgccgtgga tttgaaacgg 791581 ttctgtcgga ttgccgaatt catcccgctt caatgaatca cgaagctctt cattcagcat 791641 gtcacatgcc tcttccaaca cgctgtacac gcggtccgga tcttctttaa agctgataag 791701 aaaggattcg gtaatccgca taaaatcaat attatagttc tctatttgtc tgacctcgcc 791761 gttgctgatg gtgagcagct tcccgctcca ttcccggatt tgcagcgagc ggaggccgat 791821 ttcctccact gtcccgttga acaagttgtt gacggtgaca taatcgcctt tgtgcagctg 791881 gcgttcatat attaagaata caccagccag cacatctttg atcagcgatt gggcgccaaa 791941 accgatcacg atacctgcta cgcccgcccc ggccaatatc ttgccgaaat catgcacaaa 792001 taaagaaata acgtaaaaga taaaaccaat tgttgccgta tactgggtga cagaacggac 792061 aaggctttca atcgtttttt cctttttttc ttcaataaag tccgtccgtt taaaaaatag 792121 ctgtaccagc cggttgatga taaagacacc gatccaaagg ataacggcaa cgaggagaat 792181 atcgacgatt ttattttgaa aaatctccgt aagtgtttct ttcatccgca tctaactcct 792241 ggcttgacgt tttgtgaagt ctgtatcctg ataataactg tttttgacaa gaacattcgg 792301 tccgaggcac cggacattcg ggcagtggca actcagttct ttcgcaagct tggtctctct 792361 ccacttttca taggcggaag ggaggctgtc cgtctgaatg ttgccaagcg gcggggtatc 792421 accgaaatcg gtcacgataa tgtttccgtc gaaaatgttc acattcaggc gggatcggcc 792481 gtcagggtca tttcgcactg tgacgttttt cgccgcgcga agccggcgaa gcagcttttg 792541 gtcgtcttcg tccggactgc aggcataaaa cggcagcgtt ccgaacagca tccacgtatt 792601 ttcatcacga atatccagca agcggtgaat ggcctgtctc atctctttca ggctgaggga 792661 ttcaagagcg cttgcgaaat cgcttggata cattgggtgg acctcgtgac gctgacattt 792721 catatcttct gtgatttggc ggtgaatatg ctcaatatgc ggaagtgttc gtttgttcag 792781 catcgtttcc gcagatacca ttactccggc atccacgagc gtgcggctgt tttcgatcat 792841 tttttcaaaa tagcgcgcgc gctgttcgaa ggtcggtttt ctgtccatca tggcaaagcc 792901 gatttcagca aaatcttcaa ctgttcccca gttatgtgaa atatgtagca catcgagata 792961 cggaatgatc cattcgtacc gctcgatgtc gagggtcaga tttgaattaa tttgtgtccg 793021 cacaccccgt tcatgggcat atttcaataa aggaacaaca tattctttta ctgatttcaa 793081 cgaaagcatc ggctctccgc ctgtgatgct gatggatctg aggcgcggga tttcctccag 793141 ccgttttaac agaagatcta ttggcagagc attcgggtct ttaggctgca atgtatagcc 793201 tacagcacaa tgctcgcatc tcatattgca cagtgtcgtt gttgtgaatt caacgtttgt 793261 cagctgcatg tctccgtatt ggtcaacatc catataggct tcccaagggt caaactcggg 793321 cgtaatcgga cgcagcttcg tgttttgtgt catgactatc taactccttt ataaatgggc 793381 atactaacgc tgccaacagt taattttaga cctgatttgc caagatcgca agtagcgcgg 793441 cgattgaaaa acggcaaaaa atgagctacc ataataaaaa atgaatggag gaacagaatg 793501 gggaacgccg taaacaataa agatcagcag attgattatt taaagaacag acttgacatg 793561 tttatgaacg tcatcgattc attagaccct gaagcaaccg acgttgaaga tatagacagg 793621 cttatcagca tgcttgatga cctggaagcc aaatacgaac gttttaaaaa agattgggaa 793681 taaaaccgcg tgcccgccgc ggttttttta ttggcataaa gcaacagtat aaaacaaagt 793741 ctctatctgt aaaataagaa aaaatgcaga aggagcgctg gccatgaagt ggatgtgttc 793801 aatatgctgc gccgccgtat tgcttgccgg aggtgcagca caggcggaag cggtgccgaa 793861 tgagccgatt aattggggct ttaaacgaag tgtcaatcat cagccgccag atgccgggaa 793921 gcagctgaac agtttaattg aaaaatatga cgcgttttat ttagggaata caaaggaaaa 793981 aacgatttac ttaacgtttg ataacggata tgaaaatggc tatacgccaa aagtgcttga 794041 tgtcttaaaa aaacatcgcg taacaggaac gttttttgtc accgggcatt tcgtaaagga 794101 ccagcctcag ctgatcaaac gaatgtcaga tgagggccat attatcggca atcattcctt 794161 tcaccatccg gatttaacga caaaaacagc tgatcagatt caggatgaac ttgattcagt 794221 caacgaagag gtttataaaa ttacgggaaa gcaggacaac ctgtatttgc gtccgccgcg 794281 cggcgtgttc agtgagtacg tactgaaaga aacgaaacgc ctcggctatc aaaccgtttt 794341 ctggtcggtc gcttttgttg attggaaaat caacaaccaa aagggaaaga aatatgccta 794401 cgatcatatg atcaagcagg cgcacccggg agccatttac ctgcttcaca ccgtatcgag 794461 ggacaatgca gaagcgctgg atgacgcgat tacagatctg aaaaaacagg gctacacttt 794521 taaaagcatt gatgatctga tgtttgagaa agaaatgagg ctgccgtctt tgtaaaagag 794581 aaagacctct ccttaaacgg agaggctttt ctttatttta tacatttaat cagtgcggcc 794641 cagtccagat ccccgaagcc tttctcaatc ccgctttcaa aatggctctt ggccagctcg 794701 gcaagaggaa gatttgcaga aacccgtttt gcggcggcga gtgccaggtt ggtatccttc 794761 agccctaaag acattttgaa gccggccggc tcaaatttct gctcggccat aatggttccg 794821 taattttgat agactggaga accaaagagc gcgctggcga tttctaaaaa ttgtttttgt 794881 tctaagccgt atttctccat cattaaaaag gattcagata acgcctccag catggacaca 794941 agcaagaaat taatgctgat tttggctgca tttgccgtct tgctttcttc gccgacgtca 795001 aatatctgct ggctcaggct gtcgagcaga ggcttggcag cttgctttgc ttccgccggt 795061 ccggctgtta tgatacggag cgcggctttg gctgcggcat ccggtctgcc aaggacagga 795121 gcggcgagaa aaaattgtcc tttctctgca tgagccgctg cgagcttttc tgagaactca 795181 acactgattg tgctcatcga gatgtgtatg ccgttctctg ctaatccttc aagcagcccg 795241 tcttctccga atgtcacggt gctgacagaa tcatcatctg caagcattgt gatgacaata 795301 tcagcggact ttgccgccag ccgcggcgta tcagctgcct gtgcgccttc tgtgacaagg 795361 tcttctgtct tttgtttcgt ccggttatag acagtcaatt cgtagcctgc ttgaagaaca 795421 tttcgggcaa tgggctgtcc catattgccg agtccgatga cagcaatttt caatctaatc 795481 actccctgaa tattttttcc attataaaca atatgaacag aatatgcata gcgatcggct 795541 tacaacaaaa aagaacagct gctcgctgtc ctcatttaaa aatattgaac catcctttat 795601 gtacaaacca aatcagcatt ccaatcacaa gcgcggccat caggccaagt acagcgaaat 795661 atccgtattt ccaatgcagc tccggcataa agtcgaagtt cataccgtat acaccggcaa 795721 taaaggtgag cgggatgaaa atggttgata cgatcgtcag tgtcatcata atcgcattca 795781 tccggtttga gtttagcgtc acgtagctgt cacgcaagtc ggacgtcatg tcacggttgg 795841 attccacaat ttcagacaac tttaacaaat gatcatatat gtcgctgaaa taggctttcg 795901 tttcccgctg ctctttcaca tggtcaaggc ttaaaatccg gtagagcaaa tcacgcatcg 795961 ggataatcgt ccgtctcaaa tgcaataggt ctgttctgag atcaaacacc tcgttcatca 796021 gcgttccata cgttttgtgg ggacggcttt cttcaatttc attcagccgg tcttcaattt 796081 tatacacgag aggaaaatat tcatcaacaa gctgatccat gatcatataa gaaatatgcc 796141 cgggcccttt tttcaatatg tccggtgaag catacaaacg ctcccggact ttagcgatac 796201 cgggcgtttc gtgtaaatga aaggtgacga caaatttttc gccttgaaag atatcgactt 796261 cctccgtctc aagtgtttcc ttattcagcg catgaatcac gtaaaaacga tagccgtcat 796321 aatggtcaag ctttggccgc tgcatatgct ggaagcaatc ctcaatggca agcgggtgaa 796381 aatgaaaaaa atctctcaat aacgccgttt ccgtatcctc cgggccgtaa aaatcaaccc 796441 agtaccatgc aatatcaggc tgttccactc gttcgatcgg tatatttttc agcagctgat 796501 gctctgttgt gattgcggta atgttgatca taaacaaccc tccacctgcc attatatcat 796561 gcggtcttta tgagaaaagt atacggtact ctctgcctaa ttccagcggc atgttatact 796621 gaacaaaaac ggaaaaaagg gtggatctca tgtggaagga aaaagtatct gtcacgcctc 796681 cgtatcattt tgaccgcgtg ctggacaggc tgtctttaga ccccctcaat gctgttgatc 796741 gagaggcgag ggaagtccgt gtgccaatca gaaatcaagc gggggacgta tgtattgtaa 796801 aggtacaggc gttaggccat gcgggcgagc ctgagttcct cgtcagcggg gaaacggatc 796861 agggagaaat gatgaaggaa atcaagcgga tttttcaatg ggaaaatcat ttgcagcacg 796921 ttctggatca tttttcaaaa acgagcctgt ccgccatttt tgaagagcat gccgggacgc 796981 cgcttgttct ggactacagc gtgtacaact gcatgatgaa atgcattatc caccagcagc 797041 ttaatctttc cttcgcttac acgctaacag aacggtttgt tcatgcgttt ggcgagcaga 797101 aggatggcgt gtggtgctat ccaaagccgg aaacgattgc ggaactcgat tatcaggatc 797161 tgcgtgatct gcaattcagc atgagaaaag cggaatacac cattgataca tcaaggatga 797221 tcgcagaagg cacactcagc ttgtcagagc tgccgcatat ggcggatgaa gacattatga 797281 agaaactgat caaaatcagg ggtatcggcc cgtggaccgt gcaaaacgtc ctcatgttcg 797341 gacttggccg tcccaattta ttcccgcttg ccgatatcgg cctccagaat gccatcaaac 797401 gccactttca gctggacgat aagccggcaa aggatgtcat gctggcgatg agcaaggagt 797461 gggagcctta tttaagctat gcgtctttgt atttgtggag gagtatagaa taattcgtct 797521 gacaatgaag gaaatcctgc aaacgtgtta tactagaaag atgtgaaaaa accatttcac 797581 tttctgccat ccgcagaaag cttcatatag aaacggagag aacaacgtga accaacaaaa 797641 gaaacaggcg cccgtcgaac tgaaggtcgg acaaactttt ccgctgacga ttaagcgtct 797701 cggcattaac ggagaaggtg ttggctattt taagaaaaaa gtcgtcttcg tgcccggcgc 797761 gcttcctggc gaagaagttg ttgtgcaggc cacaaaggtc cagccgaagt tttcggaggg 797821 ccgcattaag aaaatccgca aggcatctga gcaccgggtg gcaccgcctt gccctgttta 797881 tgaacaatgc ggcggctgtc agcttcagca ccttgcatac agccagcagc ttcgggaaaa 797941 acgtgatatc gtcattcagt ctcttgaacg ccatacgaag tttaaagttg aaaacatgga 798001 aatcaaagaa acgattggca tggacaaccc gtggaattac cgcaataaaa gccaattcca 798061 gatcgggcgc tcgcaaagcg gcagcatcat cgccggctta tacggccttg attctcatga 798121 tatcgtgccg attaaagact gtatcgttca gcatccggca acgaacaaaa caacaggcat 798181 cgtccgccgc attttagagg acttcaatgt gtctgtttat aatgaaagaa aacgaaaagg 798241 cgacgttcgc acgatcgtga cgagagtcgg ctttgaaaca ggcgaagtgc aggtcgtgct 798301 tgtaaccgca aaagaaacgc ttccgcacaa ggaagaaatc gtcaaagcga ttcaaaagcg 798361 attgccagag gtcaaatcca ttattcagaa tgtaaacggg gcgaaaacct cagtgatttt 798421 tggtgagaaa acaaaacagc tcgccggaaa aacagtgatt caagaagtgc tcggcgacgt 798481 atcttttgaa ttgagcgccc gcgctttctt ccagctcaat ccggaacaga ccgtcaagct 798541 gtatgatgaa gtgaaaaaag cggcgcagct gaccggaaaa gaaaaagtcg ttgatgcgta 798601 ttgcggcgtc ggcactatcg gcatgtgggt tgcggacgga gcgaaggaag tccgcggcat 798661 ggacgtcatc aaggaatcaa ttgacgatgc taagaaaaac gccaaaaaac acggcatggc 798721 aaatgccaca tacgtaacag gaacagccga gcactggctc ccgaaatgga cgaaagaagg 798781 cttccgcccg gacgtcgtca ttgtagaccc gccaagaacg ggctgtgaca gcacgttctt 798841 ggacacgatc aaaaaagtca aaccgaaacg ctttgtctac gtttcctgca atccatccac 798901 gcttgcgaaa gatttgcaga cgctgtcgaa ggactatcgc gtggactata ttcagcctgt 798961 cgatatgttt ccgcagacgg cgcatgttga agcagtggcg aggcttgtat taaaatcgtc 799021 taactaaaaa gaacatttcc cagtcataaa atagttttcc taataagacc tggatttcgg 799081 taaaataaac aattccgatt tccgggtctt tttcgtgcgc agctcttgtc ctaacggtct 799141 gttctcaatt ttatcttcct tcttttcgcg gagatcttta ttttaactgg cgaaaagaat 799201 tgaaaaaacg tgttgaaaag caggtgaaaa aaagcgttat ttaaccggaa aaatatcctc 799261 ccagtatgtt taaaatacat gagtagaatg atgtaaaatc atagatgtat tttcataatt 799321 tgtaaaatta tatattgact tgcagttatt acgtgtgaaa tattgatgat aggaatataa 799381 ggaaagtatg gcgtatatca tttcaagagt cattcgatgt aaaaagttga aacattgtaa 799441 taaatgaaag aggtgaaaat gatggccaac cccattttaa aatgcataac gtatgagcac 799501 tacaacaatt aaataatagt gccgagacga taacaactat tacagtaata cctacaatgg 799561 ttatatcctt gcgacaatca tgcttcataa tataatgatt ttagattgac acttggctaa 799621 aaagtattgc agagaaggaa atggataatt aaatggataa agtatataaa agaagttggt 799681 ttcaaacatt tttggcattt ttagtatctc agctttattt taattttgta gaattaacgg 799741 gatggggtcc taagtataga gaaatgaatg gattcccagc aaacatagtt gaactagatt 799801 tctttcaaac atatctttca ttctatgata atccatggtt taatattatt actgttttct 799861 tgggagtttt cactattata caaataatta cagggataac aaaggatatt cgaaattaaa 799921 gcaataactt ctgatgcctt atttaatgat gaaagaaaat gtacactttc ttaattatct 799981 tatgagtgaa gactgcgaca cttagtcagc agtctatttt atggttctgg atcaggatta 800041 ccgaattata accctataca aatatatagt aggttgccac ttgctgcgtt ggttattttc 800101 taaatcatga gcaaatccca aatgattcag attgaagttc ttgaattctt ttaaataagg 800161 gtttattttc tcttctcatc ctctttactc catgtgattc acaagtggta gcagcttaag 800221 taggtttttt cattctcttg agtactcagt tataccaccc ccaactcaat ttgctttatc 800281 tctattagtt tttccgcaaa tatgatatag agatacggat atggtgtagt gttaaatatc 800341 ttatcttcaa taacagggca attattttgc gttggtaata tggagaactc atatgatatt 800401 ctatttaggt tggaatcctt tttatccaaa aagttcaaaa gcaaggccac taagaaagac 800461 gaaggtcagc gccagttaac cagaatataa aaaatagggt agataatcat cccacgtgaa 800521 atcttcaaaa tttactatag attgataaga aatgctttcg catgcgataa gtgtaaaaga 800581 agcatggtca gtttttaatt tgggataaag gttcagccgt atcccataat gaaaggattt 800641 gatttttgtt atgacagaaa atttctggcg tgaattacca cggccgtttt ttgtactggc 800701 accaatggaa gatgtgacag atgttgtttt ccggcatgta gtaagtgaag caggcagacc 800761 ggatgtgttt tttacagagt tcacaaactc agagagctat tgccacccgg atgggaagga 800821 tagcgtgcgc ggccgtttga cttttacaga ggatgaacag ccaattgtgg cccatatatg 800881 gggagataag cctgaaaact tccgtaaaat gagtattggc atggcagagt taggatttaa 800941 aggactagat atcaatatgg gctgccctgt gcctaatgtg gcggggaatg gaaagggaag 801001 cggccttatt tgccgtcctg cagttgcggc agaattaata caagctgcaa aagcaggggg 801061 attgcctgta agcgtgaaga caagacttgg atacacggat gtggatgaat ggcgcgagtg 801121 gctgacacac attttgaaac aggatattgc gaatctttct attcatctgc gtacaagggc 801181 agaaatgagc aaagtagatg cgcattggga gctcatccca gagattaaga aacttcgtga 801241 cgaggtggca ccagatacat tgctaacaat aaacggggat attcctgacc gtcaaactgg 801301 cttgaaactt gctgaacaat acggcgtcga tggaattatg atagggcgcg gtatttttac 801361 aaatcctttc gcttttgaaa aggagccgaa agagcatagc agcaaggaat tgcttgatct 801421 cttaaggctg catctggatc tccatgatga atattcaaaa gaagaagccc gtccatacaa 801481 gcctcttcct cgctttttca agatttatct ccgcggattc cgaggggcaa gtgaattaag 801541 aaatcaatgc atgaacacaa agtcaacaga tgaagtgcgt gcattgctcg acgactttga 801601 gagaaagtat cttgatggga tagagtaaca gcagtgcttg attcaaaaaa ggctaacaaa 801661 ataaagggat ttttacacaa ttcttgacta aaataaacct ggattttcgg taaatccggg 801721 tcttttttgt acgcagcttt tactcagcct gtcttttctc taatttattg taagaaaata 801781 atggtatatt tagtggagat atcatataaa gggggagagg aaaatgaaac ggctatgcat 801841 catcccctgc ggcaagaaaa aaatctggga tgtccagcct gatgccgggc cggtaagagc 801901 agaggacgct tatctcagcc cgtttcatca ggcgtgcgag cggtatgcaa aaacattttt 801961 cgatgagtgg gtgattttgt cggcgaagca cgggttcctc cgccctgatg atctcgtttc 802021 gggaaattac gatgtcactt ttggcaccgg tcatccggaa atcatgacag cggacgagct 802081 gcgccgtcaa tttcacgaaa aaggcttttc tgatatcgaa gagctagtca tgcttggcgg 802141 aaaaaaatat cgaagcgttc taaacgccgt catcggagaa caccagcata tcagctggcc 802201 gctatcatca tacaaaggca taggctatat gctccaagcg ctgaaccggg ctgttgaaga 802261 aaagcatgaa ctgtagcacg tacatatgag gaaaagagtg ggaacatgaa aaaacttgtg 802321 tttggcttgc ttgccattgt gttattcgga tgcggactat atatctatca tgtatggttc 802381 ggtgatccat tttcgaaaaa tgctgcagaa cagaagctag tgtcttatgt gaaacaaacc 802441 tatcctaaga aagaaatcaa gatcacgaat ggggtatata acgctaaaac gtctgaatat 802501 gtatttgaag caacctccca atctcatcgc tacccaatgt gtacgaaggg atttctgcat 802561 cctaaagtaa cgtgcgatgg aattgaagaa gcgtataccg aatcagtagc aaaacatgta 802621 aatgaagaag caacgaaggc aatcgaagca gatctgaaaa aagcggttcc tcgatttata 802681 aaagctgatg ctgctttgag tatcgaaaac ggacagttca cgttagatac aaaatggaac 802741 aaaaagctgg ctgaaaaagc gcctatgagc atgacgattc agttagacgc cagcgggtta 802801 tcaaaaacag atgccgcaaa gatggcggaa acggtcagaa aaacgcttaa tgaaaaggga 802861 tatacatact caaacggcac gatagactgt atgcagaagg acggggacgg cggtattgga 802921 tatgtcaaat attcaattga ttttctttca aaagcagcta ttcagtcaaa cgatgcagag 802981 gaactaggaa gttaaaaaga tttccaagga aataaatacg tcgatcattg tcaaaggccg 803041 ggtgatatcc ggtctttttt ttgcatgctg taaaacgaga caaatgaatc agtttgagac 803101 aaaacgagac acacgtctca aactgtctcc aaagtgaaga tgagaagact gattttacgg 803161 gctcaaaaga ctggcacact tcttgcattt ataatggtga accctaaata gaaggaggcg 803221 cacaaaatga aattgttaaa acgagaaggc ttgtcattaa ctgaggaaaa agcgctgtgg 803281 atgtaccaaa agatgctgga gatcaggggc tttgaagaca aagtgcatga actgttcgcc 803341 cagggagtgc ttcccggatt cgttcattta tatgccggtg aggaagccgt ggctgtaggg 803401 gtgtgcgctc atttacatga tggcgacagc attacaagca cccacagggg acatggacat 803461 tgtatcgcca aaggctgtga cctggacggc atgatggcgg aaattttcgg gaaagcgacc 803521 ggattgtgca aaggcaaggg cggttctatg cacattgcgg atcttgataa aggcatgtta 803581 ggcgcaaatg gaatcgtcgg gggcggcttt acgctcgcat gcggatcagc gctcacggct 803641 aaatataaac agactaaaaa tgtaagcgtt tgctttttcg gggacggggc aaataaccaa 803701 ggtaccttcc acgaagggct gaatttagcg gctgtatgga accttcctgt cgtatttgtt 803761 gctgaaaaca acggctatgg cgaagctacc ccatttgagt acgcatcagc ctgtgattca 803821 atcgccgatc gggcggctgc ttataacatg ccgggggtta cagttgacgg caaagatatt 803881 ttagcagttt accaggcagc cgaggaagcg atagaaagag caagaaacgg cggcggcccg 803941 tctttgattg aatgtatgac ctacagaaac tacggccatt tcgaaggaga tgcccaaacc 804001 tataaaacga aggatgaaag agttgagcac cttgaagaaa aagatgccat tcaaggtttt 804061 aaaaactacc ttttaaaaga aacagatgct aataagctgt cagacattga acagcgtgtc 804121 agcgaatcga ttgaaaaagc cgtctcgttc agcgaagaca gcccatatcc aaaagattcg 804181 gagctgctga cagatgtgta tgtgtcatat gaaaaaggag gaatgtaaga gatggcgaga 804241 gtcataagca tgtcagacgc gatcaatgaa gcaatgaagc ttgcgatgag aaaagacgaa 804301 aatgtgcttt tgatcggtga ggatgtcgcc gggggagcgg cggtcgatca tttgcaggat 804361 gatgaagcat ggggcggtgt attaggggtc acaaagggac tcgtacagga attcgggcgt 804421 acaagagtgc tggacactcc gatttctgag gcaggctata tgggagcggc tatggctgcg 804481 gcatcaaccg gtttgagacc gattgccgag ctgatgttta acgattttat cggcacgtgc 804541 tttgatcagg tgatcaacca aggggcgaaa ttccgttata tgttcggcgg aaaagcgcaa 804601 gtgccgatta ccgtccgcac cacatacgga gcagggttcc gggccgctgc ccagcattca 804661 caatcgctgt atggcctttt cacgagcatc cctggactga agacagttgt tccatccaat 804721 ccgtatgatg ccaaaggtct tttgcttgca gcaatagaag ataatgatcc ggtgtttttc 804781 tttgaagaca aaacgtccta caacatgaag ggcgaggtgc cggaagatta ttatacaatt 804841 cccctcggaa aagcggatat caaacgcgaa ggcaatgatg ttacgctctt tgcagtcggc 804901 aagcaggtca atactgcgct tgaagcggct gcacagcttt cagagagggg catcgaagcc 804961 gaggtccttg atccccgcag tctgtctcct ctggatgagg atgcgatttt cacatcgtta 805021 gaaaaaacaa accggctgat catcattgat gaagccaatc cgcgatgcag cattgccacg 805081 gatattgctg cgcttgtcgc tgacaagggc tttgatttgc ttgatgcgcc gattaaacgg 805141 attacagcgc cgcatacacc ggttccgttt tcaccagtgc ttgaagatca atatttgccg 805201 acaccagata aaattgtcag cgtcacgctt gaattgcttg gcgagccggc attgaattaa 805261 aggggggaca caaatggcgg taaaagtagt gatgccaaaa ttgggaatgg ccatgaaaca 805321 aggggaagta tcgatatgga ataaaaaagt aggcgacccg gttgaaaagg gagaaagcat 805381 tgccagcatt caatcggaga aaattgaaat ggagatcgaa gcgcctgaaa aaggaacgct 805441 gatcgatatc aaagtgaaag agggagaaga ggttccgccc ggcacagcta tctgctatat 805501 cggggacgcc aatgagtcgg tgcaggaaga ggcgggggcg cctgttgctg aagacaatat 805561 gccgcaagcc gtccagcccg tcaaacaaga aaacaaaccc gcagcctcca aaaaagatcg 805621 aatgaaaata tctccagtcg ccaggaaaat agcagaaaaa gcaggattag acctaaaaca 805681 actgaaagga actggaccag gcggacgaat cgtgaaggat gacgtaacaa aggctcttgc 805741 tgaacagaaa aaagatcaag caaagcctgt ttcggagcag aaagcgcagg aaatcccggt 805801 gacaggcatg agaaaggtca tcgctgcccg aatgcaggaa agcctggcaa acagcgcgca 805861 gctgacgatc acgatgaaag ctgatatcac caagcttgcc actcttcaaa aacagctttc 805921 accaactgcg gaagagagat acggcacaaa actgacgatc actcattttg tctcaagagc 805981 cgccgttctc gctctgcaag ctcaccctgt gctgaacagc ttttatcaaa atgagcgcat 806041 catcacacat ccccatgtgc accttggtat ggctgtagcc ttggaaaatg gcttagtggt 806101 gcctgtcatc cgccatgctg aaaagctatc gctgattgaa ctggctcaat ccatctcaga 806161 aaatgccaaa aaagcacgcg agggacgtgc gggaagcgaa gaactgcaag gatctacttt 806221 ctccattaca aaccttggcg cgtttggagt tgagcatttc acaccgatac taaatccgcc 806281 ggaaacaggc attctcggca tcggagcaag ctatgacaca ccggtgtatc aaggggagga 806341 gatcgtcaga agcacgatcc tgccactcag cctgacattt gatcacagag cgtgtgacgg 806401 cgcccctgcc gctgcattcc tgaaggcgat gaaaacatat ttggaagaac ccgcagcatt 806461 aattttatag gaaaagcagg tgaaaacgac atgacattag ccattatcgg cggcggacct 806521 gcaggctatg cggctgcggt ttccgcggca cagcagggca gaaacgtgct gctcattgac 806581 aaaggcaagc ttggggggac ctgcctgaat gaaggctgca tcccgacaaa gtctttgtta 806641 gaaagcgcaa acgttcttga taaaatcaag catgccgaca gctttggaat cgaacttccg 806701 gcaggtgcga tatcagtcga ttggagtaaa atgcaaagcc gaaaacaaca ggttgtcagt 806761 cagcttgtcc aaggcgttca gtacctaatg aagaaaaatc aaatacaggt tgtaaaggga 806821 acagcctcct ttctttctga aagaaagctc ttgatcgaag gagaaaacgg aaaagaaatc 806881 agagaggcgg accaagtatt gattgcctcc gggtcagagc caatcgagct gccttttgcc 806941 ccatttgacg gcgaatggat cctcgacagc aaagacgcgc tttctctttc cgagattccg 807001 tcttcactag tcattgtcgg cggcggtgtc atcgggtgtg agtatgcagg gctgttcgcc 807061 agattgggat cgcaggtgac catcattgaa acagcggacc ggctgatccc ggctgaagat 807121 gaagatattg cccgtctctt tcaggagaaa cttgaggaag acggtgtcga agtgcatact 807181 tcatccagat tagggcgggt ggatcaaacg gccaaaacgg caatatggaa aagcggtcag 807241 cgagagttta aaacgaaggc cgattatgtg ctggtggcga tcggcagaaa accccgtctt 807301 gacggattgc agctggaaca ggccggagtt gatttttctc caaagggcat tccggtgaat 807361 gggcacatgc agacgaacgt gcctcatatt tacgcgtgcg gagatgctat agggggcatt 807421 cagctcgcgc atgccgcttt ccatgagggc atcatcgctg cttctcatgc ttccggaagg 807481 gatgtcaaaa tcaatgagaa acatgtgccg cgctgcatct atacgtcccc ggaaatcgcg 807541 tgtatcggaa tgacagaacg acaggcaaga agcatatacg gggatgtgaa gatcggcgaa 807601 ttttcatttt ccgcaaacgg caaggcgctc attaaacagc aagcggaagg aaaggtcaaa 807661 atcatggctg aaccggaatt cggcgaaatc gtgggtgtct cgatgattgg cccggatgta 807721 accgagctca tcggccaagc ggcagcgatc atgaatggtg agatgacggc agatatggcg 807781 gagcatttta tcgccgccca tccgacttta tcggaaacat tgcatgaggc gctgttaagc 807841 acgatcggcc ttgcggtaca tgcataataa aggaaaaagc aggcgcatgg atataaggcg 807901 cctgcttttt tattgttgaa agcgctttat ttttccccta caatagatga aaacggcgtg 807961 taagggagga gcgatcaagg aaatgaattc ggtcccaaac gatttgcaaa cctggaaacg 808021 ttttgtgaaa gacggtgtgc ttgacgaagc ccgattaaga aaacggattg cagagtcatg 808081 gcatcgctgc aaaaaagctg aggtcaatcc ttatttagaa aaaggcccga aggttttaca 808141 gcaaacggag ctggatcagc agtcaaaaaa acattcattc ttcttgacga ccgcaaagcc 808201 ttacctcgaa aaactgctgc ctgccataaa agaaatggaa atgatggcgc tgttaattga 808261 ttcagacggt gttgttctgg cattggacgg ccatccgcgc gcgctctatg aagccaaacg 808321 catcaatttc gtcgaagggg catgctggac agaaacggct gtcggaacaa atgcgattgg 808381 cacggcgctc cacatcagcg agccggttgc aatacaagga tcagagcatt actctatcgc 808441 ttcccatctt tggaactgtt cagctgctcc gattcaccat gaggatggca gccttgcggg 808501 tgtaattgac atatcatgcc cggcggcagg cgcgcatcct catatgcttg gtattgccac 808561 ggcgattgcc tatgccgctg aacgggaact cgcagctaaa agccgtgaga aagagctgga 808621 gctgatcagc cgttttgggg agagagctgc atccagtgtg ccgatggtgc tctgtaatac 808681 caagcagcac atcatcagtg cgagcatgcc gattcgaacc tcaatgccgg attggcaggg 808741 ccggcacctg tacgagttga aggaacgggg ctattcaatc gaaaatgctg tcaccatagg 808801 agatggcggc acttgttttt atctttcgga acaaaagaaa aagaaggcgt ttcgattcaa 808861 tggagtgatc gggcaaagcg gccgatcgca agcgatgctg atgcaccttg aacgagcagc 808921 tgcgacggat gcatcggtct gtttgtcggg tgaaacgggt acggggaagg aggtcgcggc 808981 tcgcgcgctt catgagaaca gtgagagacg gcacggtccg tttgttgctg tcaattgcgg 809041 agcgattccg tctgatttga ttgaaagcga actgttcgga tatgcagagg gcgcttttac 809101 gggagcgaaa cgaaatggct ataaaggcgc ctttcaaaaa gcgaatcaag gcacattatt 809161 tttagatgaa atcggagaaa tttcccactc gatgcaggtt gcacttttac gggtgcttca 809221 ggaacgcaag ataacgccaa tcggcgggac gaaagaaatt ccggttgata tcagagttat 809281 tgccgccaca cattgtgatt tacgcgagct tgccgaaaac ggaaaaatca gagaggactt 809341 gttttaccgt cttcatgtct atccaattga actccctcca ttacgcgatc gcaccgagga 809401 tatcccggat ctctttgagt actacaaaca gaagaatcat tggccaggcg atcttccttc 809461 tgatttttgt aatgtgctga agcaatggaa gtggccgggg aatatccgcg agctgtttaa 809521 tgtgtttgaa cgtctttcta tcagatttcc ggacggccgg ctgagagatg aatcgcttcc 809581 cgctttactg gaagccgctg gattgccggc cagctctgca gaaaaaaagc cggctgctgc 809641 cggcgtgctt acttttcgtg agcaaatcca aaaggatatg atgatcaaag cgcttgaatc 809701 tgcaaaagga aacgtctctc aagccgcaaa aatcagcggg atcccccgaa gcactttcta 809761 caaacgcctg aaaaaattca acttgtccgc tgaatcataa agcatacttc cttcaggaaa 809821 tggaaacgtt atgtattgaa ggagggtgtt acgatgaata ttcaaagggc gaaagaaatt 809881 gtagaatctc ccgacatgaa gaaagtaaca tataacggcg ttcctattta cattcagcac 809941 gtaaatgaag aaactggaac agcaagaatt tatccgcttg acgaaccgca agaggagcat 810001 gaagtgcagc tgaacagctt aaaagaggat taaacaaaaa tggcccgctt cataagcagg 810061 ccattttgtt atccgcgcgg cgcaaataaa ataacacaga caccgatgag acaaatgaat 810121 gcgccgatcc agtcatacag atcaggtgtt ttccggtcaa caagccatcc ccacaggacc 810181 gcaagcacga tgaatactcc gccataagcg gcgtatacac ggccgaaaga tgggaaggac 810241 tgaaacgtcg gaagaatgcc gtatacaatg aggatcagcg ccccggcgat tccgtagcca 810301 gctggctttg cctctctcag ccatagccaa accagatatc cgccgccaat ttcagcaagc 810361 cctgccgcga gaaataaaag aatggtaatc agcatcatga gcactcctca atttgcattt 810421 atctttcatt atagaggagg agagctttta aagcttcgga tgattctcaa attccttcaa 810481 atacgctttt cgctgaacct ctgtaaattg gctgatccaa ttgttttgag cctcttcatt 810541 caaatgggga aggatatagc gttcaaccgc ttcgaaaaac agcggattcg tgatgatgtt 810601 ccaggtcggg attcgaacga ttttgccgtc tgttttctcg atgataatat cctcaaaaaa 810661 gatccctttc aaactgtatt gatggcgtcc catataaagc cgcttcacct cggaaaacag 810721 cacgctgcgc tttctcaaga agatttcgcc actaggtccg gtctttatgg tgaaaatgac 810781 atttccacgg cttgtgaacg caggaaaagc cataaagaat gtgatcaatc cataaatcat 810841 cgccagtaat ccgccgccca aataaagcag ggcatattta gattcaaacg tgagggcttc 810901 agacaccagc cagactccca caataaaggc gccccctgta gcgaggaaca gccaagccct 810961 tagaaacatc atgcttttta cttcaatcat gtgctgcccc taaagcttcg gatgattctc 811021 aaattccttc aaatacgcac tgcgttggat gtctgtaaac tgtccgatcc aattgctttt 811081 cgcctcttca ttcagatgtg gaaggatata gcgttcaacc gcttcgaaaa acaacggatt 811141 cggaatgatg ttccaagtgg gaatgcgaat ggtcttctga tccacggttt ggatcaatat 811201 atcttcttgg aagattcctt ttagactaaa tttatggcgg ctcatctcaa ttttcttgat 811261 atcagtaaac gtaacagaca ctttgtcagt gaacacttct ccattttttc ctgtcttgat 811321 gcggaaaatg gtatttcccc gcggggtgaa agccggaaag aagatgataa ataaatataa 811381 acaaaacaag gtgaacagaa agccagcagg aatggctaat aggtaatatt tcgtttgaaa 811441 cgtaataccc atataaaaga gccacaaaca tgctaatccc ataccggcag atccgacaaa 811501 agcccatatt ctcaggaaca ttttgctttt gacttcaatg atttcttggt ttttcaatgc 811561 ttttctcctt ttgttaattc aattcttatc attttgaaat gatttgattt acaacatcct 811621 tatgagcagg gaggatagaa aattcattct gggtgatgcc tgtgacaagc caagtatggt 811681 gggcccccgg caggacgaat gccatgtcag ccacttcagg agtgttatct tttccatatg 811741 ccagacgcat aagtgtatcc attttccctt tccgcaaagc cagatcattt gcaaatcggg 811801 taacgtcctc ttggtggtca tgtttttcaa ggaactcttt tagatatgaa gggttgtctg 811861 aagcgccctc caagagtttt tcaaattcat ttgatgtcaa tgttacaatc gattctcttt 811921 tatcctctgt atctattata tgtaaaaact catctgtctt agcaagtaac ccttcacttg 811981 attccatttt tgtaatgcga tggacttgtt catcaaaaag gagttcgtga gagtaggtgc 812041 cgaattttga tacatggcat gacacattct gttcggcacc ttgcccgtta aatttagaaa 812101 gcttcactgt atagtcagcg tcgtttaata catggataaa cggacagtac tcgtccttta 812161 accgatattg atggttccga tattccgctg catccttggc taagagtgag cggcacgcgg 812221 cttcaaataa ggcgccgagc tgttcatctt ctatttccgg aaaataggcc tgcttcaagg 812281 ccattccctg ttcaaaaaac ccttcgctgt aaaagcaaaa caagagttct tctatgctaa 812341 ttgtaaactg cttcattgtt tattctccta tccaaatgaa aatttccctt taaggaaatg 812401 ggttgcgccg tgtataagcg aatccgctgt tttctttgct ttttccattc cttttttcgc 812461 gctgtctatc cctttatgta tcgatttatt cgccgcatct atgccgtcat tcactgattt 812521 gacgactttg ccggctgatt ccagcccttt tttggctgta tcaacaacag catggatcgg 812581 ttctttcagc tttaaggctg ctttttcagc aaaaccggct gtatatttgg cgatttgttc 812641 tccgacgact ccgccaatgt atgaacctgc tgccccaaga aggacagtac ccacaggtcc 812701 tgcaaagctt ccgattgcac cgccgatgac agcaccagct gtggcaccgc cggcaacaaa 812761 aatcgtatta ttcacagcat tcccgacggc cttggcgttt tcacgcttga gaacttccgg 812821 tttatcctgg tattttgcat aattttcagc aattttcacg cctgctccga atgtttcggt 812881 cgctccggta atcagtgtgg cggtaatggc atttcctttc gcgaatctca agcccgtttt 812941 tcccacatcc ttcaaagtgg agcgtacgcc ggcttcatta agaaatcctt ttgtgtagct 813001 tctgacgctg tttgaaaaat ccaccgtgtc ctgaggaaag tattttgtaa actttttatg 813061 taccaaatct gaaaatggac ggtttgtctt tttcaacaaa tatttaggat tcaaaagcac 813121 tcttgccgct ttttgataac gtgagctgtc aacggccctg gaaatatcca agagcagttt 813181 tgagtgctgg gctgtatgca agccgcttgg ttgtttcaca aatttcgtaa gccctaatcc 813241 gtaatatttt ccctgcgtca gcataagagc ggttaagctt gtcatcgtac cgtatttgtc 813301 gtaggcattg tagagctttc gcaaaatatc atcttgttcc acaaatttat cgcctgtttt 813361 tctgatgaaa atctcattgt cactcagctt agtgacgagc gcctttcctg agctccacgc 813421 atcgcccact ccagaaaaac agctgctgta gcggggatcg cattgcaaaa tcatctgccc 813481 cagctccaca tgcaggtcct tatatttgtt ttccatatca gttaattcag tgactacatc 813541 atttgcaagc tgttcgagct tatccggatc aactgcaatg tttcctgaca caccgttcac 813601 ctcccgagtt tatgtctttc ctctcttgct ttacgctcca gttcttccat tctggcaatt 813661 tcagcttttc gttcttctat tttgacagcg gcagccttca gctcttggct tgtttcaagc 813721 agctcctgtt cgaattgatc gtaggcggct ttcgtttcct cgaaatcctg gtcaaacgaa 813781 tctcttgctt tgccctgcca agcatctccc aatgcagata accgggattc aagcagcatt 813841 ttggagcttc tgacctcttc tgcggccgca ctatacttgt ttgccagctc aatgacttta 813901 tatgagtcca acttttgtcc cctgcctttt ctaaattcac gcacaattgg atgttttata 813961 taaatgatta taaataattc ggcatgtatc cgaatcgtac aaaagaacct tttcataaga 814021 attggaaggg cgtatattca cttaaaattc acagttggtg agactttaag attacaaaaa 814081 aggtaaaaaa accaaatctc tcagacataa ggcaaatgag aaatttcccg ctctatggga 814141 aaaaacacta aagttgatca aatgacctaa gtgcgccaaa cgtgttacgg gacgagctat 814201 ctcatggtat aaatggaatt gtaaacgtta tcaaggaggt cgtcatatga agaaaaaatc 814261 attctcaatc gtaatagcgg gcggagggag cactttcact ccagggatcg tactcatgct 814321 cttggaccat ttggaggagt ttccgatcag aaagctgaag ctgtatgata atgataagga 814381 gagacaggat cgaattgcag gcgcctgtga cgtttttatc agagaaaaag cgccggatat 814441 tgaatttgca gcgacgactg acccggaaga agcttttaca gatgtcgatt ttgttatggc 814501 gcacatcaga gtagggaaat acgcgatgcg cgcgcttgat gagcaaattc cgttaaagta 814561 cggagttgtc ggccaggaga cgtgcgggcc gggcgggatc gcatacggta tgcgttcgat 814621 cggcggtgtg cttgaaatat tagattacat ggaaaaatac tcgcctgatg cgtggatgct 814681 caattattcc aatccggcgg caattgtggc tgaagctacg agacgcctta gaccgaattc 814741 taaaattctc aatatctgtg atatgccggt tgggatcgaa gaccggatgg cgcaaattct 814801 tggcttatcc tcaagaaaag aaatgaaggt ccgctattac ggattgaatc atttcggctg 814861 gtggacatcg attcaggatc aagagggcaa cgatttaatg ccgaagctga aggaacatgt 814921 atcccaatac ggttatattc cgaaaacaga ggctgaagct gtggaggcaa gctggaatga 814981 cacgttcgcc aaagcgcgtg acgtgcaggc tgcagatcct gacacactgc cgaatacgta 815041 tttgcaatat tatttgttcc cagatgatat ggtgaaaaaa tcaaatccga atcatacgcg 815101 ggcgaatgaa gtcatggaag ggcgcgaagc ttttattttc agccaatgtg acatgatcac 815161 acgtgaacag tcctcggaaa acagcgaaat taaaatcgat gaccacgcat cgtatatcgt 815221 tgatcttgcc cgggcgattg cctacaacac aggtgaaaga atgctgttga ttgttgaaaa 815281 taacggtgca attgcgaact ttgacccgac tgcgatggtt gaggtgccat gcatcgtcgg 815341 ctcaaatgga cctgaaccga ttaccgttgg caccattccg caattccaga aagggctcat 815401 ggagcagcag gtatccgttg agaagctgac tgttgaagcg tgggcagaga aatcgttcca 815461 aaagctgtgg caggcgctga tcctgtcaaa aacagtgccg aacgcgcgtg tggcaagact 815521 cattcttgag gatttagtgg aggccaacaa agacttctgg cctgagcttg atcaaagccc 815581 aacccgcata tcataaatga aattccccca ttttcgaatc tgtaattgta tataatagaa 815641 agaaaatggg gggatctgat atgcagctcg aagaactgat caatcagcac tacagcaaat 815701 tgaatgacaa cgattttcat attttaaaat atatattgaa tcataagcac acatgctatc 815761 accttggaat cgacgcgctg gccaaagctt gcagtgtatc gcgttcctca attttacggc 815821 ttgcccaaaa gctcggtttc agcggttaca gtgaatttcg cgtcttttta aagtgggaag 815881 atcagccgga agaaggcgag agtatgagtt ttgaaaagct gcttgatgat attgaagcaa 815941 atttgaagtt tttacggaca aaggacatga cggacatgtg ccagctgatt gatgcagctg 816001 accgcatttt cgtctacggt tctggaaatg cgcaaaagat atgcgcccgc gacctgcaaa 816061 gaatgtttat tccgcgccat cgctatctta ttttgattga agacacaaat gaatttaatt 816121 tgatgcgcga tgattttaaa gtgaacgatc tgtttatcat catttctctt tccggagaaa 816181 caccggagct gattcctcag gcaagaatgc tttctgcaaa gggtattccc tttatttcca 816241 ttacgaattt aaaaaacaat gtcctcgccc agctgactcc gcataatctt tatgcgacaa 816301 gcaaacctgt gacattaagc gatagaacgg aaattgtcgc ttttgcaccg ttttttctcg 816361 ttggcgaagc attgttccgc gcatatgttg attacaaaga ggcagaaaaa aatgacaatg 816421 agtagcaggg ggttctggta tgatgcaaaa aattcagcgc tttggaagcg cgatgtttgt 816481 gcctgtttta ttattcgcgt tcgccggcat tatcgtcggt atcagcacgc tctttaaaaa 816541 taaaaccctc atgggaccgc tcgccgatcc tgacggtttt tggtatcagt gctggtatat 816601 cattgagcag ggcggctgga ctgtttttaa ccaaatgccg ctcttattcg ccattggcat 816661 cccggttgct ttggcgaaga aagctcaggc acgcgcctgt ttggaagcgc ttactgtcta 816721 cctgacattc aactattttg tcagcgcgat attgacggta tggggaggag catttggcgt 816781 cgacatgaat caagaggtcg gcggaacgag cgggttaacg atgattgcgg gcataaaaac 816841 gctcgatacc aacatcatcg gagccatctt tatttcttcg attgtcgtct ttttgcataa 816901 tcgctatttt gataaaaaac tgcccgattt tctcggcatc tttcaaggct caacatatat 816961 cgtgatgatt tccttcttta ttatgatccc aattgcgttg gctgtgtctt atatttggcc 817021 gatggttcaa tcgggaatcg gctcgcttca aagcttcctg gttgcttctg gggcggtggg 817081 cgtttggata tacacgtttt tggaacggat tttaattccg accggccttc atcactttat 817141 ttacacgccg tttatttatg gcccggctgt agcggaaggc gggatcgtca cgtattgggc 817201 acagcatctc ggcgaatatt cgcaaagcgc caaaccgctg aaggagctct ttccgcaagg 817261 cggattcgcg cttcacggca actcgaaaat cttcggtatt ccgggtatcg ccctggcttt 817321 ttatgtgaca gccaaaaagg aaaagaaaaa actcgtcgca gggctgctga ttcctgtcac 817381 actgacagcg attgtcgccg gtattacaga gccgattgag tttacgttct tattcatttc 817441 acctttctta tttgcggttc acgccgtgct tgccgccaca atgtcgacag ttatgtatat 817501 ggccggcgtc gtcggaaata tgggaggcgg actgattgag gcggtaacct tgaactggat 817561 tccgctcttt ggcagccacg gtatgacata tgtgtatcaa attttgatcg ggctctcgtt 817621 tacagcaatt tattttttcg tcttcagatt tttaatcctc aaattcaata tcgctacacc 817681 aggacgggaa aaggatgaac agcaggaaac aaagctatat tcgaaaaagg aatacagaga 817741 acgaaaaaac aaggatgaaa cggcctccgc tgctgaaacg gctgatgaca ccgcttttct 817801 gtatattgaa gcgctgggcg gaaaagacaa catcactgaa gtcacaaact gcgccacccg 817861 cctcagagtc agtgtcaagg atgaaacaaa ggttgaaccc gacagcgtat tccgcgcgct 817921 tggcgcacac ggcgttgtca ggaacgggaa ggcgtttcag gtaattatcg gattaagcgt 817981 gccgcagatg cgggagcgtg tggaaaaaat attgaatcaa taaagactgc cctccttttc 818041 gggagggttt tcgtttgccg tcaaaaagac cgccatagta aagtaaagaa agagacaatc 818101 gagtaaaaag gggtttggag gcttttacat gcaaaaggct ttgtcgtttt taaaaccata 818161 ttcattgctg gcgggaattg ctctgattct tatgctgacg gagcttgcag ttgaactgat 818221 gcagccttta ttgattgcaa aaatcatcga cgatgggata ttgaagcaag atctgcggca 818281 tgtatggata tggggcacgg tcatgatcgg gctgaccgtg ttatcctttg cggcggggat 818341 gctgaattcc ttttatgccg cccatgtcag ccaaagcttt tcctatgata cgagaaaagg 818401 gctttttcaa aaaatccagt ccttctccta ttccacattt ggacagtttt cgtcctcttc 818461 ttatattaca aggctgacaa acgacgtcac acaggttcaa aatatgattt ttatgagttt 818521 gcggtttatg ctgcgggctc ccttaatgat tgcaggcggc attgtgctgt cgcttgccgt 818581 taatgtgaaa ctcgggtttt ttctgcttgt gaccattccg atcctgatct tgtttttgct 818641 atgggtatta aggaaaggcg gggcactgtt ccgctcagtg cagaaaaggc tggatcaagt 818701 gaacaccatc atgcaggaaa atttaattgc aatcaagctg atcaaagcgc tgcttcgcgg 818761 cagccacgaa gtcaaacgat ttatcaaagc caacacaagg ctgatggaaa aaacggtttc 818821 ggcctttcag cttgtggaat tcacgatgcc tgtactgatg ctgctgatga atctctgcat 818881 ccttttgatt ttgtgggcgg ggtcctacag tattacgagc ggaagcactc aggttggcga 818941 tgttgttgcg ataattaact acgcaacacg aattacaggc gcgctttcga tgtttccgtt 819001 tttgattatg attttcaccc gggcgaaggc ttcaggggat agaatcggtg aggtgcttga 819061 aacagaaggc gacgagcggg aggaaggcac catatctgat cgtttgtcag gacggattga 819121 gtttcagcat gtatcctttc gctatcctga aatggacaga gaagcgctca ggaatgtctc 819181 attttccgca aagccaagag aaacgatcgc gattctcggt gcgacgggct cgggcaagtc 819241 cacgcttttt cagctcattc cgcggcttta tcagccggat tcaggccgca tttacataga 819301 tgaaaagccg gttcaagata ttccggctga agggctgcgc aggcaaattg gatatgtacc 819361 gcaggaagtc ctcttgtttt ccggcacaat caaagaaaac atcgcttggg gcaaagaaaa 819421 tgcttcacta gatgaaataa tggatgcggc aaaacttgcg caaattcatg aaacgatttt 819481 aaagctccca aatggatatg acactgtttt ggggcaaaga ggcgtcaacc tgtccggcgg 819541 ccaaaagcag cggatttcca ttgcgcgggc gctgattcga aaaccggcta tccttctatt 819601 agatgacagc acaagcgcgc ttgatctgca aacggaggcg aagctgcttg aagcaatcag 819661 cacataccat tgcacaactt tgatcattac acaaaaaata accacggcga tgaaagctga 819721 tcagattttg ctgcttgagg acggcgaact gattgaaaaa ggcactcaca gtgagctgct 819781 ttctgaatct cagttataca agcgcattta cgagtcacaa ttcggaaggg aggggagcga 819841 gtcatgctaa aagacatccg caagcctttc caatatccca aactgccaat tgacaaaaaa 819901 gaaggcgcga aaaagcgggc gaaagcaaag gatacaaagg gcacactgag acgaatctgg 819961 tcttacttgg ctgaaagaaa aggactgctc atacttgtca tgctaatggt tgtcatcagc 820021 gccatattcg gactccttgg tccctttgtg atcggaaagg ccatcgacca ttttatcgtc 820081 gggaaaacgg tcagcggctt gattcctgtt ttgcttcttc tgctcgctat ctatatcatt 820141 cagtccctgt cgctttggtt tcaaaactat tggatgatta cgatctcgca gggcacggtt 820201 ttcagaatga gaagcgaatt gttcacccat ctgcatgagc tgccgattcc attttttgat 820261 aaacagcggc acggcgagct gatgagccgg gtgacgaatg acatcgaaaa tgtcagttct 820321 accttaaaca cgtcagtcat tcaaattttg tcaagtgtga tcacctttgt cgggacgatt 820381 gcggtgatgc tgtacatgag cccgctcctt actttgatta cgctgaccat tattccggtg 820441 atggcagcga gcctgaaatg gatcaccaac cgaacgggaa agctgtttaa agaacagcag 820501 aaaaaccttg gtgatctgaa tgggtatatt gaggaatctg tttcaggcgc aaaggtcatc 820561 aaagcatatt cacgtgagaa gcagattact gctgaattcc tcgaaaaaaa cgctgcactc 820621 aagacgtcgg gcttttgggc gcagacgatt tccgggttta ttccgaaggt catgaactct 820681 ttgaataact taagctttac aatgattgcg gcaatcggcg gtttgtttgc gctgaaaggc 820741 tggatctcga tcggctccat cgttgtcttt gccgagtatt caagacaatt tacacgccct 820801 ttaaacgatc tggccaacca gtttaatacg atgctgtccg caatcgccgg cgctgaacgg 820861 gtgtttgacg tgcttgatga aaaagaagag cgcgaggatg aaaagaacgc cgtgcatcag 820921 cccatccaaa caggcagcat tgaattccgg gatgtgtcct tcggttacga taaagggcag 820981 cagacactga agcatttaca gtttaccgtg cctgcggggc agtccatcgc gtttgtagga 821041 ccgacggggg cggggaagac aaccgtcact aaccttctcg cccgttttta cgagcctaac 821101 gatggaaaaa ttttaatcga tggtacagat attaaaaccc ttactagagc aagcctaaga 821161 aaaaacatgg ggtttgttct tcaggattct ttcttatttc agggaacgat cagagaaaac 821221 attcgctacg gcaggcttga tgcttctgat caggaagtcg aagccgctgc aaaaacagcg 821281 aatgcccata gttttattga aaggctgcca aaagggtatg acaccgtact gacgcaaaac 821341 ggttcgggca tcagtcaagg gcagaagcag ttgatttcta tagcgagggc ggtgcttgcc 821401 gatccggttc ttctcatttt ggatgaagcg acaagcaaca ttgataccgt tacagaagtc 821461 aacattcaag aagcgctcgc ccgtttaatg gaaggaagaa caagcgtcat cattgcccac 821521 aggctgaaca ccattcaaag agcggaccag attgtggtgc taaaaaacgg tgaaatgatt 821581 gaaaaaggca gccatgacga gctgattcgg caaaaaggat tttacagtga cttatatgaa 821641 agccaatttg agaaatagac ctttgtcctg cacagaggtc tttttttgtt acagttttat 821701 agtactttta tttcattttc gtaaaatgta acaaaattac ttgacgtaaa caagttatgt 821761 atatatacta gcttacatta agtaagtgat aacatttatc aaggaggata aaatgaataa 821821 atcatttgaa attggcacat tacttttaag agttattaca ggtattatct tttttgttca 821881 cggtttatca aagtttcagg gaatggaggg caccatccaa tttttcggca gcataggcct 821941 tccaagcttt atggcgtatg tcatcgcagc gattgaactg attggcggag tgcttgtctt 822001 cttcggattg gctacacgta ttgtcggtgt actgttcgct cttacactga tcggcgccat 822061 catcactgtt aagctgaaag cgccattcat gggcaatgca gaatttgatt accttctgct 822121 tttgacatcc attcacctgg cgcttactgg aagtcgattc ctggcgctgg acccatttgt 822181 gtttaaagga aaaaagaacg gaaacgtttc agcataagaa aagaggcatg cagcatgacc 822241 agcattcatg aggatacaca cattggctat gccaaactca caattcgcag tctggagcgt 822301 tcgcttcagt tctactgtaa cgtcatcggt tttcaagtct taaaaaagac ggaccgccaa 822361 gcggaattaa cggctgacgg gaaacgcgta ctgcttattc ttgaagaaaa tccgagcgct 822421 gtcgtcttgc ctgaacggtc tgtgacaggc ctttatcact ttgcgattct tcttccggac 822481 aggaaagaac ttgggatcgc gctcgcccgc ctgattgaac acggcattgc tatcggacat 822541 ggagaccatg ctgtcagcga agcgctctac ctgtctgatc ctgacggaaa cggcattgaa 822601 atgtacgctg accgcccccg cagcacgtgg cagcgtgatc gggaaggaaa ctacgtcatg 822661 acgacaaccg ctgttgacat tgagggcctt ctggaagagg caggagatga gcggaaaaca 822721 tcgcttccga acgatacaat catcggacac attcatctgc atgtcagtga tttgaaagaa 822781 gcaaaggcgt tttatacaga tgtactgggc tttgacattg tcggaaacta tgcgggcatg 822841 tccgccctct tcgtttcagc cggggggtac caccatcata tcggcttaaa catttgggcg 822901 ggaagaaatg cgccgcctaa accgacaaat gccagcggac tagattatta tactgttgtc 822961 ctgccccacc aagaggagct ggatttggtg gcaaaccgag tcaaacatgc cgggtattcg 823021 attgaagaga cggaaaacag ctttcgtgtg aaagaccctg tttccggcgc ctatattaca 823081 tttgtgattt aactgcaatc cccttgccga aataacggca gggggatttt ttatttttgt 823141 ccgccttgtt atgatgagag aaccaacttg ttaggaggcg tttacatgga actcaaccac 823201 cttgtgacgg gcaaaatagc attaaatcaa tatgtgcatc gcttagagca aaaggatgtt 823261 tcattttacg tccactactg gggagcgatg acgaaccact ataacacact gcttcataag 823321 cattcctttt atgaaatttg ttacgtggta agaggtgaag gatattacct tgaaggcgat 823381 cgtacatatc cgcttcgtga acagacgatt tttttgtcaa agccggagca tttgcaccaa 823441 atcaaaagtg aaacagggct gttccttttt tacgtcgctt tcgagctgag cgaggatcag 823501 tcaagcgccg aatggatcaa agtgatggaa gaagtgaaac aaagcccctt tatcacaatg 823561 caattgaaag atggcgaacc gccgggcctg ctttggaaaa cgttaatgct gcaagcagcg 823621 caacctgtca atgcttttga caaagagatc ctatctcatt tgtcgcatgc attgatcctg 823681 tcattaatcc aaacctttct cccgtacgcc caacgcccga aacaaaagca gcccattcac 823741 acatcttctg ctttgctgac agaggtgaaa ctgcacataa aagacaatct gtcacagccg 823801 ttaaagctga cggatgtcgc tagccacttt catatctcag ggaggcattt atcacgttta 823861 tttgcagcag aactgggcgt cagctactca gaatttgtcc aaaatgaaaa aataaacaaa 823921 gctgccgaac tgctgaaatc aacgaatttg tcgattaaag aaatagcgga agaaatcggt 823981 ttctcagtac attatttcac tcgcgtcttt tccgctaaaa tcggcagctc tccagggctt 824041 ttccgctccc tttataaaga ctcaaaaatg accgcatttc aaatcaataa accttttcaa 824101 aaaatcgaac aggccaagcc gcacgaataa gatgtcctga aatgacaaaa caatgtcttc 824161 atatgataaa gacgcgagaa atctcgttgt cttataatct ttttagaaag cggttacaac 824221 aaggggtatt gctgaaggag ggatgcattg gcttatgctt ggtgtcgggt gctctgccat 824281 tcttgaaaga aggggaagaa agccgtgagt acaaaaaaga aagaggctgt aataggaaaa 824341 gaaagcttag ctcataaagg gcttttacga acgattacat tggtatctac attcggcggc 824401 ctgttgttcg gttatgatac gggtgtcatt aatggggcac ttccttttat ggcaactgca 824461 ggtcagctga atcttacacc tgttacagaa ggactggttg cgagttccct gcttctcggg 824521 gcagccttcg gggcgatgtt tggaggacgt ctgtccgatc ggcacggccg ccgaaaaacg 824581 atcctttatt tagccttact cttcatcgca gccacacttg gctgtacctt ttcaccaaac 824641 gcgtccgtga tgattgcctt tcgttttctg cttggactgg cggttggctg cgcttctgta 824701 acggttccaa cctttttagc ggaaatttcg ccggcagaac gcaggggacg aatcgtgaca 824761 caaaatgaac tgatgatcgt aattggccag cttctggcat acacctttaa cgccattatt 824821 ggcagcacaa tgggggagag cgcaaatgta tggcggtata tgctggtcat cgcgacactt 824881 ccggctgttg tgttatggtt cggaatgctc atcgtgcctg aaagcccgcg ctggctggca 824941 gctaaaggca gaatgggtga cgccctgcgg gtgcttcggc aaatccgtga agacagtcag 825001 gcacagcagg aaataaaaga aatcaaacat gcgattgagg gcacagcaaa aaaggccggc 825061 tttcatgatt ttcaagagcc gtggataagg cgcattctat tcattgggat tggaatcgcc 825121 atcgtacagc aaattaccgg tgtcaattcg attatgtact atgggacaga aattctgaga 825181 gaagccggtt ttcaaacaga agctgcatta atcggcaata ttgcaaacgg tgttatttca 825241 gttattgcgg tcatttttgg gatatggctt ctcggcaaag tccgtcgccg gcccatgctg 825301 atcatcggac agattggcac gatgacagcc cttctgctga tcgggatttt atccattgtc 825361 cttgaaggaa cacccgccct gccgtatgtt gtgctgagtt tgaccatttt gtttcttgcg 825421 tttcagcaga ctgccatttc tacggtgacg tggctgatgc tctcggaaat ctttcctatg 825481 catgtgcggg ggcttggcat ggggatcagc accttctgct tgtggacagc taactttctc 825541 attggattca cctttcccat tttgctcaat catattggga tgtcggcgac attttttatc 825601 tttgtcgcta tgaatatcct agcgattcta tttgtgaaaa aatatgtgcc tgagacaaaa 825661 gggcggtcac ttgaacagct tgagcattcc tttcgccagt atggccgccg cgctgatcag 825721 gaaatccaaa atcaaacaac tcacttatcg taacctgaga taccaggagg aatctatcaa 825781 tgaaactatc ttatgtaaca gacagcctag ggcatttgcc ttttgaagac atgctcaatt 825841 ttgccgcaaa gcttgggatc gatacacttg aaatgacaac cgggggctgg tcgccggcac 825901 ctcacttgaa tcttgatgaa ttgctgcaaa gcagcgaaaa aagaaaagaa ttttcacaag 825961 cgctggaaaa gcggaacatg acactttgcg cattaaactg ctcggggaac cctttagatc 826021 cgggtgaatt gggcaaatcg cacagagaca taactgacaa aacgatggag ctggctggat 826081 tattaggcgt caaaaaagtg atcatgatga gcggtttgcc agccggcggc ccggacgaca 826141 aagtgccgaa ctggatcaca tacacagtaa gctggcctcc cgttttaaaa gatatcctca 826201 actatcaatg ggaagacgtt gcgatcccat attggaagaa gcttgtcaaa aaagcggagg 826261 cctgcggcgt ggggaaaata gcgcttgaga acttcagctc tcaattagtc tataatcctg 826321 agactctctt tcggctcaga aatgcagtcg gcccgatggt cggtttgaat cttgacccga 826381 gccatttgtt atggatgggc gcagacccga tcatcgcagc aagggagctc ggctcagcca 826441 ttcaccatgt ccatgggaaa gatgtcagaa ttgaaagata tttatcggcg gtcaacggac 826501 ttttagaaac aaaagaagtg acagatcctg caaaccgggc gtggaattac gtagctgtcg 826561 gctgtggaca ggatttacag tggtggaagg aatttttttc agttgtaaaa atgatgggat 826621 atgaaggtga ggtttcttta gaaatggagg atctgacgat gtcacctgaa gcgggcatcc 826681 gtacttctgt agaagcttta aaacaaacca tcagccaata ggaggttttc atgatgctaa 826741 atggagaaag aatcatctct aagccgcttc gctgggcaat ggtaggcggc gggcggctca 826801 gccaggttgg atataaacat cgtattggag cgctgagaga caatactgct tttcaattaa 826861 ctgctggcgc ttttgatatc gatgccgaaa gaggaaaaga tttcggggtg aaccttggag 826921 tggatgcgga acgctgttat cccaactatc aaaccatgtt tgccgaggaa gcgaaaagac 826981 aggatggcat agaggtagta tcgattgcca ctccgaacgg cactcattat gagatttgta 827041 aggcggcgct tgaagcagga gtgcatgtca tctgtgaaaa accgctgttc ttcacttcag 827101 cagaggggca ggaaatcaaa gcgctcgcag agaaaaaagg gaaaattgtc ggcgtgacgt 827161 acggtttttc aggcaatcaa atgcttcttc aaatgcgtgc gatgattgaa caaggaatga 827221 tcggcgatat tcgcgtggtt gacttgcagt acacacacgg tttttgtgca acagatgaag 827281 gtgaaaagat aagcgctgca cagaaatggc gtgtcgaccc tgcgatcgcc gggccaagct 827341 ttgtgctggg cgatttatct acccacacgt attatatgtc acagcttatt atgccaaaga 827401 tgaaaattaa ggagctgctg tgtgaccgac agagcttcgt cggcagccgc gcaccgctag 827461 aggataatgc ccatgtgctg atgcattatg aaaatggagc ggtcggaacg atgtggacat 827521 cgtcaatcaa tgccggatgt atggatggcc atagaatccg gattgtcggc tcaaaggcaa 827581 gcattgagtg gtgggacagc aagccaaatg aactgacgta tgaagtgcag ggagagccgg 827641 gccagacact cgttcgcggc atgccgtatt tagatgatgt ttgcaacgcc gatgaacgac 827701 tgggcgcctt acacagcgaa gggctgtccg aagcatgggc caatatttat cttaaatttg 827761 ccattgcgat agacgccaaa aaccgtgaag atgaagaaat cttgaacaac ttggtttatc 827821 ctgacattga tgcagggatc gagggcattc gctggattga gaactgcgtg cgctcggcaa 827881 accaagggtc agtttgggtt gaatttaaat aaatgaggga atgcgccgca tatgacataa 827941 agttcatatg cggtttttat tttccagaaa ctcctgtcaa aaatgccctg aggcaggtat 828001 gataagaagg gaattgggta tcgggagtga tgagcgtgaa agctcttttt tttacgagaa 828061 tgttcacctt gatggtgagc tgtttaatgt atctgtccat tgtgaaagag gataactggt 828121 ttggatatgt atttatagca gcaggtgctg ccatgtatgc agccaatcat gttttgctga 828181 caaaagagac aaatgccatc tggttctgcc tgattgatat tgcaatcggc ttttcgttcg 828241 gatttatctt tcccggcaca ggtttgttca ttattatgct ttgtccggtt gcggtcgcct 828301 tttttctgcg ggggtttcct aaaagaacag catggtctgt cttatgtctt tcctctattt 828361 tatttttgac cgtcctcatc cgtacatatg cgatgttcgg caatgaattt gtcattgatc 828421 atttgactag catgacattc gttgtcttct gcggtgtcgt gggcaaatta atccgcaagc 828481 tgttggatgc gcaggatacg gcaaaacagc agtttcagga actgacggag tcccatctgg 828541 cgctgtctgc tgcacatcag gagctccatt tatatgcgaa gcaggttgaa gagctgactg 828601 ccatttacga gcggaacaga atggcgcgtg aaatccatga tacagtgggg cataaaatga 828661 cggcccttct cgtccagctg cagcttttgc gtgaatggca aaaaagagac agccaaaaag 828721 cggatgagac agtaggtgtc tgtgaaacac ttgcccgtga agcgcttgat gatgtccgct 828781 tatcagtacg cactctgcaa actgaaaacg atccttcgct aatcgaatcg ctgaaacagc 828841 tgacagagga cttttgcaaa aatgcaggag tcacaacaga atttgcggtc agcggtgatc 828901 ctgcaatcat cccgctgtct ctccatccga ccctgatcag aacggtgcag gaagcactga 828961 ccaatgccaa acggcacggc ggcgccgcag cctgttcgat acagcttgcc tgcacaacgg 829021 acagcatcag ccttgtcatt aaggatgacg gcaaaggcaa tcctgaggca gcacttggtt 829081 ttggtctctt gaatatgaaa aagcgggcag cggagcatgg cggaatgatc cgctttgaaa 829141 gcgaacggga tcaaggattt actgtaaatg cagaattttc acttgccaat aaaaaatgga 829201 gcttcgggcc cgtgcagcaa aaggagagtt tatcatgatt aagatcatca ttaccgacga 829261 tcaggatatc gtcagagaag ggctggcatc cctgctccag ctccgagaag agctcgatgt 829321 gatcgcaacg gcgcgaaacg gacaggaagc cttcgaaaag gcgaaagagc tggagccgga 829381 tatcgtgtta atggacatcc gcatgccggt ttccaacggg gtggagggaa caaaattaat 829441 cacaagctcg ctgccaagcg taaaggtttt gatgctgaca acctttaagg attcagcgct 829501 gattgctgaa gcgcttgaag agggagcaag cgggtatctg ctgaaggata tgtctgcaga 829561 tacgattgta aaagcagtga tgactgttca ttctggcgga atggtgcttc cgccggaatt 829621 gactgcccaa atgctgaatg aatggaagcg tgaaaaacag ctgaaaggaa taaatgagat 829681 agaaaaacct aacgagctgc tcgacctgac cgagcgcgaa atcgaagttc tggctgagct 829741 gggatacggg ctgaataaca aagaaattgc cgaaaagctt tacattacag aaggcacagt 829801 caaaaaccac gtttcaaata ttatcagcaa gctggctgtc agggacagaa cccaagccgc 829861 catttactcg gtcagatatg gtgtatctgt cttttgacat atgacgtttt gcatatacgc 829921 ttctctgaaa aggcctttta caggcctttt tttcatgccc tatgttctat ctgccgctac 829981 atgccgcacg cctttctttc ttctacaatg gcaatggatc aaaaaaagga gtgagacgac 830041 gtgctgcaag cagaaaacat caaaaaggca tacggaaaaa aaacaatcgt gaaaggcatt 830101 tctttttccc tcaaaaaggg ggagtcgttc ggtctgctcg ggcctaacgg tgcggggaaa 830161 tccacaacca tctcgatgat ttccggcctt gtgccgcatg acagcgggaa catcacggtg 830221 ggcggctatg ttatcggaaa agaaacggcc aaagcgaaac aaaaaatcgg cattgttccg 830281 caggaaattg cattatatcc gacgctgacg gctcatgaga atcttatgtt ttgggggaaa 830341 atgtacggac ttacgcacgg tgaggccaaa aaaagagcgg ctgaggtcct tgaatatgtc 830401 ggtctgactg agcgggctaa agataagatt gaaacatttt ccggggggat gaaacgaaga 830461 atcaacatcg gtgcggcttt aatgcataag cccgagctgc tgattatgga tgaaccgact 830521 gtcggtattg accctcaatc gagaaatcac attttagaaa cggtcaaaca gctcaacgaa 830581 acgggcatga cggtgatcta tacgagtcat tacatggaag aagttgagtt tttatgcgac 830641 cggatcggga taattgatca gggggaaatg attgcgattg gcacaaaaac tgatttgtgc 830701 agccgccttg ggggcgatac catcattcag ctcacggtca gcgggatcaa tgaagcgttt 830761 cttgtggcga tccgatctct ggcccatgtg aatgatgtaa cagtacatga attagagctc 830821 aaaattgaca tttctgcggc tcatcatgag aaagtcgtca caagcctgct tgctgaagcc 830881 actgctcatc atataaacct gctgtctctt caggtgcagg aaccgaatct ggagcgcctg 830941 tttctgaatc tgaccggccg cacgttgcgg gattgaggag ggacggcaat gaaaaaaagc 831001 atatggatcg catggaaaga tgtgaaaatc agaatcacgg acagaaaagg gtttatgatg 831061 cttatcctaa tgccgctcat cctaacctgt attttaggcg cagcgctcgg atcagttgtt 831121 gacggaggca gccggattga tgatatcaaa gtcggctaca ttcaatcaga ccagtcagat 831181 acagcaaaca tgtttacaaa agatgttctc aaaaaaatga agtcgataaa ggtcacaaaa 831241 gtcggcagca aagacaagat gaaaaaactg attgatgaaa agaaaatcga tgtaggcatc 831301 gttatcccga accattggga agccggcaaa acctcagctg ttgttaatgc cgctcctgat 831361 caaacattga aaagttccat cattgaaaca gctgcaagct catttataga gcaatataaa 831421 gcggtaaagg aagccgcgtc aggctcaatg gactacatca gtaaaacgga agctgtaaag 831481 caaggaaaac ttgaccctgc acagtttgca gaaaagctgg caaagacgct agaaaaagaa 831541 acaggtgaca agcttactat tgcggaaaaa tctgtcggca gcaaagccgt taccagtttt 831601 caatactatt cggcggcaat gctttgcatg tttatgctgt ttcatatcac agtcggggcg 831661 aaatcatttt tacaggaaaa ggatacggag acgcttgcca gaatgctgat gacgcctgcg 831721 caaaaatccg tcattctctt cggaaaatgg cttgggacgt atctgtttgc catcatacaa 831781 tttttcatat ttctgatcgt cacaatcaac gtatttggtg tggactgggg cggtaatctg 831841 ctgttagtga gtgtactcgg gctttcttac gccgcagctg tatctggtat ttcaatgctg 831901 cttgcgtcgt gcatcagcga tatgaaaact gcagatgcga taggcggctt cggcattcaa 831961 ttgcttgcgg ttctcggcgg gtccatgctg ccgctgtacc aatttccgga cgtcttgcag 832021 tctgtatcca aagcggtgcc aaatcgctgg gcgcttgacg gctttctttc tttaatggaa 832081 gggggaggct gggctgacct tcaaaagcct gtgcttcttt ttgcggcgat cggcttttgt 832141 tcacttgtaa ttggtatcag acggcttcat acaagataag gaggtacaaa aggtgaaaaa 832201 aattctagcc atttgcggca ttgagctttc tctcattttt aagaagccac agaactattt 832261 gatcatgttt gctgccccgc ttttgcttac ctttgtattt gggagtatgc tcagcggcaa 832321 tgatgataag gtgcggcttg caatcgttga tcaggacgat acgattctct cacagcatta 832381 tattcggcag ctgaaggcac acgatgatat gtatgtattc gaaaacatgt ctgaaagcaa 832441 agcgtcagaa aagctgaaac aaaagaaaat tgccgggatc atcgtcattt cccgctcgtt 832501 ccagacacag ctggaaaaag gcaaacatcc tgagctgatt ttccgtcacg gccctgagct 832561 gtcggaagcg ccgatggtca aacaatatgc agaaagcgca ttggcaacgc tcaatattca 832621 ggtgaccgcg gcaaaaacgg catctcagac agcgggagag aactggaagg cggcgtataa 832681 aacggttttc gccaaaaaac atgaagatat agttccggct gtaacacgac agacgctcag 832741 tgataaaaaa gagggtgcgg aagcaagtga cacagcctcc agagcagcag ggttttccat 832801 cctgtttgtc atgctgacca tgatgggagc ggctggaacc attttagaag caagaaaaaa 832861 cggcgtatgg tccagattgc ttacagcctc tgtcagccga gccgaaatcg gtgctgggta 832921 tgtgctgtcc ttctttgtca ttggctggat tcaatttgga atattgcttc tttccaccca 832981 ttggctgttt ggcatcaact gggggaatcc ggctgcagtt attgtattag tgtcactttt 833041 tctattgacc gttgtcggca ttggattgat gattgcggcc aacgtcagaa cgccagaaca 833101 gcagcttgcg ttcggcaact tgtttgtcat cgcaacatgt atggtgagcg ggatgtattg 833161 gccgatcgac attgaaccga aatttatgca atccatcgct gaatttcttc cgcaaaagtg 833221 ggcgatgagc gggttgacag agattatcgc taacggtgcc cgcgtcacag atattctcgg 833281 aatctgcggc attttgcttg catttgctgc gatcactttc gcagcggggc tgaaagcgct 833341 ccgagcctaa aaaacatctg ccgtttaggc agatgttttt ttgcatgtgg gtacattcgt 833401 atgggtgcag cctgaactgc ggttaatcct tatctatcat agctaaaatt gattccagcc 833461 aagaaacgta atttttctcc cgctccagcg ctttcgttag cacaagatag tggccgaagt 833521 ccggtgaaga aaatgacatc ggctctgctg aagccataag cttttcatag cttccctgta 833581 agtcagaaag cttggcctgg cgtttttgca gctggtcttt gaacaaatca gaagcctcct 833641 ggcgcgatag acaagaaatg aaataagcct tcagcataaa ttcatccttc accgtctcgg 833701 gtatcggctg gtggcggatc agccagtcat gcagctcctg ctttccgctg tctgtcaggg 833761 tgtacatctt tttctccagc tttgtgccct gaatcgttgt ccggaacgtg ataaatcctt 833821 catccgtcag ctttttgagc tcagggtaaa tctggctgtg cttggcgctc caaaactggc 833881 cgagctcctc tttaaaataa ctcgtaatat cgtatccact caattcgcct tttcgcaaaa 833941 gccctaatat ggcgtatttt aatactctca tgctatcctc cgtgtctggc tgtttcgcaa 834001 aacagatgag ccggtgctca actgtgattc taactgccta ttccccttat tatagaaaag 834061 ggaggaaggg aacacaaccg ggctctttgg aaatgaagat aaaaggtttg tcagaaggta 834121 tccgatttat ctccgtcaat ataaaagaga tttaaattta attttcagaa aaaatagtaa 834181 cgatattgat tttttatata taataggaaa ttggtggtat gaaaattttt tgggggaata 834241 aacgtgaaaa aagtacttat ggcattcatt atttgtttat cgctgattct atctgtttta 834301 gccgctccgc cgtctggcgc aaaagctgag tcagtacata atcctgtcgt tcttgttcat 834361 ggaataagtg gtgcatcata caactttttc gctattaaaa actacttaat ttctcaaggc 834421 tggcaaagca acaaactgta cgcaattgat ttttatgata aaacaggaaa caacctaaat 834481 aacggcccgc agcttgcttc atatgttgac cgtgttttaa aagagactgg ggcaaaaaaa 834541 gtagatattg tggctcatag tatgggaggc gccaatacgc tgtactatat taaatattta 834601 ggcgggggca ataagattca aaatgtcgta acgcttggag gggctaatgg tttagtgtca 834661 tcaaccgcgc tgccgggcac agaccctaat caaaagatcc tctatacatc tatttacagt 834721 ctcaatgatc aaattgtcat caatagcttg tctcggttac aaggagcgcg aaacatccag 834781 ctttatggca tcggtcatat tggcttgctt tctaatagcc aagtgaacgg ctatatcaaa 834841 gaagggctga atggcggagg cctcaataca aattaatatc ttcaaaaaac aacctgctgt 834901 ctccgttaca gtgggttttt tcgtctgaga aagccatagg gtcttatgac cttagtctat 834961 catgcatacg tcaatttatg acatcaggca ctttttcaaa tagagcggac atgttaaggt 835021 acaaccatcg atttctatca atttgaaata aaaggagcgc tgttatgcaa attaaagaaa 835081 tttttatgat ccgctgcatt tcgtgcttaa gtgtcgtctt gctccatatc atttcaatgg 835141 tcctgatgct tcaggcagaa gctcttgcag atatttctca cactgttgat tctttccgca 835201 cactcctgat gttcagcacg cccgctttta ttttcatctc tgaattttta ctggcccgtt 835261 cttatcctga tggggtgcct gacggttttt taaagaagcg gggaaaagtg atttttgttc 835321 cttttttatt tatcgcagcc atcgatgcgc tgctgatgac cagtgcgatg gggggagagg 835381 taacctttct cgcgtttgtg caaaaatatc tggcgaacgt attcttagga aactttatcg 835441 gatacttcat tctcgtcatc tttcaatttt acatgctgca tatgatgttt catgagtatt 835501 tgaaaaaagc atcgccgaaa tgggtgctgt ctatctcatt tgtggtgaca gccgcttatt 835561 taggctattt ctccgcagcc agcccggctc ctgcttctga agagggaggg gcatttccgt 835621 tcttctgggt tccgttcgca ggctggcttt tctacttttg tctagcctac tattgcggaa 835681 aagaatacaa gcgtttttta gcgctgctga accaataccg ctgggtggtg tacggcgccg 835741 caattgcttc tggggcgctg gttgtcactg tttcttatgt cggtgaaatc ggcatgatca 835801 gctcgaagcg gcctgatatc atgctgtatt caacaagcat gattttcctg tgttttcatt 835861 tgttttccaa aatgaagcat gtgccgaaaa tcatgatgtt tatcagcaac tattcctttt 835921 cgatttatct gcttcatgcc tattttatga ttataggcta cgtgttgctt ttgaatatgc 835981 ccgaaattcc tgccgtaccg gctgttctcc tgttgtttgc cgtgtgcaca gccggcccga 836041 ttatgacctc atgggcgctg aataagttca aatacgggta tttatttgtg gggaaaattt 836101 atcagccaaa acagaagaag gtaacagtcg aagtgcgtga tcacgcaggg tgaaaaacaa 836161 gcggcaggag ggctcctgcc gcgtttcttt acttctcatc cgcttgcaga actgttttta 836221 aatatagttt tgcagactca gcaagtccag atacatcagc cttttcttca tcgaaataca 836281 gggcgttttg aatgatgccg tcattcatat tgaggaaaaa cttggcgata gtcgcaagag 836341 gctgaaccgg ctgaaactct ccctgatcga tccctttttg caatagcctt gaaaaccttt 836401 ccacaaaaag atcatacctt ttctccaaat actgccgccg ttcttcattg cgccaagctg 836461 tcactaaata ttcaaattgc accggcgcca gcgtatctgc tacatctcgc aggccctcag 836521 tcagttcatc caaatagctg gaaatggagg cccaaacact ttggtgttca gctgatttat 836581 caagctttcg gagtccttca tccagccctg tttcaataat gcggcgaaac atctcctcag 836641 tgcttgaaaa ataaagatag acaccgcccc ggctgaaacc tgactcttct acaacatcct 836701 tcatcgtcgt taattcgaat ccttttcgtt taaaaaccgt tttggcagcc tctaaaatct 836761 ctgcctgccg tttatccttg tgctcctttg ttacttttgg tgacaagata tcgcctgctt 836821 tctgcaattt tcttacctat aagtgtaatc aacccaatca tgatcagcaa gcagccacag 836881 acaagaaaag caagtgatac accgatccat tccgccagca cgcccccgcc cgccatgccg 836941 aggatagagg cgagggttgt cgcactctga atagcgccga acaccctacc gctgtaatcg 837001 acaggcactg ttgtttgcac gagaatctga aatggaatat ggacgaggcc gaaagccgcc 837061 cccatgatga aaaaagcaaa tataaagaga gtgatgccgg caattcccat accgcttagg 837121 aatggcgcac ctccagttgc tagtccaaga agaagggttc cagctgagaa ataaagcaaa 837181 taagaagtga ttcgccgtct gccggtaatg gccgctgtaa ggagcatccc ggctccgctt 837241 acggccatgc accagcctgc cagctcgggc ggagctcctg aaaaggagcg gataagaata 837301 atcgcttggg aatcaccaat ctgcaaaaca aagagaacga cacaagctgt tagtaagcct 837361 gttaatagaa gcggcatccg tttcaaaaac tgaaggcctt ccttgataga agtaagtgct 837421 gctgtttttt cttgaggtgt attggctttt tgtaaaaaag catctctggg aaggaaaaac 837481 aaaatgacag cggaaagaaa gaaggcgccg gcgtttatat aaaaaacaga gtgtatcgag 837541 aaagcagcga tcagcgtgcc gccaagggca gggccgaaga tttttgagct gttatcaatg 837601 atgctgctga cggaaacggc ctgctgaatg tgtgcttccg gagccaattc cttaagcttt 837661 ccgtttttag caggtaaaaa aagtgaagaa aaacagctct gaacggatag caatacgtaa 837721 agctgccaaa gctcactgac ataaacgcag ctgataacag tgagggcacg gccgatttca 837781 gatagaaaca tgatcgtttt tctgtcaaaa cggtcggcaa gcagacccga tacaggtccg 837841 agtacaatga caggcaaagc aaacgacatc attaaaagcg acatatctaa tggagaagca 837901 tgaagctgaa aagcggctaa tgttagcacg gccaaaatgt gaagccagtc tccaagtgaa 837961 gaaatggttt gcgaggctaa cagtgtcatc agtccttttt gattgcgaaa caacggtttt 838021 tccatgattc atcctcctga ttattaaaat gacactagtg tcgtttttaa ttgtatggga 838081 aaaagacaca atatacaatc tttttcttgt aaaataaagg agaagattga atagaaggga 838141 gaacattcat gacatcagtc aatctaagct acccaatagg agaatacaag ccgagggaat 838201 ccatatcgaa ggagcaaaaa gataaatgga ttcaagtact tgaagaagtg ccggcaaaat 838261 tgaagcaagc tgtagaggtc atgacggaca gccagcttga cacaccgtac cgggacggtg 838321 gatggaccgt tcggcaagtt gttcatcatc tggctgacag tcatatgaac agctatattc 838381 gttttaaatt gagcttgacg gaagagacac cggctatccg tccgtatgat gaaaaagcat 838441 ggtcggagct aaaagactcg aaaacggcag atccgagcgg ctcactcgcg cttttgcagg 838501 agcttcacgg aagatggacg gctctgctcc gcaccctgac ggatcagcaa tttaagcgcg 838561 gattttatca ccctgataca aaggagatca ttaccctgga gaacgcgctc ggcctgtatg 838621 tctggcactc acatcaccat atcgctcata ttacggagct ttccagacgg atggggtggt 838681 cttaacgctt ttgccggcgg aaagccggaa tactgatagc agcaatcacc agaagtgaga 838741 ccacagcagc cgctgcatat aaatgatcat agccgctggc gacactcgca tgaatggcgt 838801 cgcttatcgc ggttttgact tcaggaacgg gaatgcgttc gatttgttct tgtaaagaag 838861 aaacttcaga actgtcgatc tccggaatca tctgcatcgc cttttctgaa tatccgctgt 838921 ccgataagcg gctgttgatc tcatcaccta tttggtcaaa cccggctgtg ataaaacctg 838981 cataaagagt aggcgccaag gtcagtccaa tttgccttac taatgaaagc gtgccaagag 839041 ctgtaccctt atttgttttt gccgcttctg atacaaggac gttcagcgga gcgcctaaca 839101 gaaagccaaa accgatccca gctgccacac ttgcgatcac aaactcccat ttttccgtga 839161 cccagagcgg aaataaagca aaccccgcac atgagatgat tcccgaaaga ataacggttt 839221 ttacaggacc ttttttgtcg gtaagtgctc cgccaagcca agcgccgatt ccggaagcca 839281 acgcaagcgg tgtcatccaa tagcctgctt ttgcggcagg gacacccaaa tactgttcga 839341 catatgacgg gataaaaatg actgccgcca agagcccccc ggataacaaa ccgatgataa 839401 gcgtgcgctg aaacatatgg tttcgcagca gagaatacgc caaaatggga tcgcctcctc 839461 gcatttcaac tctcttttca tacgagataa gcgctgcaaa acagagtatg ccaaaaataa 839521 tacatccata aacctccgga ttccccaagc tgtgtaagag atttgccccg tcaagattgg 839581 tcatgccgta catcacagct aaaatcgaca gggacaaaag gaagattccg gccgcatcga 839641 ggcgcttagc ctcaggtgct tttgtttccg cgataaaaca tgcgccgaaa acaaccaata 839701 gcacggcaat cggcaaatta atcaaaaata gccaatgcca agacccggtc caatcaagca 839761 gaaagcttcc gatatttggc ccgagcacag cggccatccc gttcattgcg ccaagcagcc 839821 caagcgcctt cccctgtttt tcctttggaa gggtcgcgag aatgtgagag ctgccgatga 839881 tgaaaatccc gccgcctcca agcgcctgaa tcagccgcga tatcagaaag agcgggaagc 839941 tttggctcaa agcaacaagc aaagaaccaa gtccgaacag gcaaacctca atgagaaaga 840001 gtttttttct gccgtagcgg tcggaaagtt ttccgacgat tggcacactg acgctaagac 840061 cgagcgtata aagggtaatg ccccatgatc cccaggaagg ggaaacggaa aacgactcgt 840121 ttatcgttgt taaagcagcc gaaataattc cgttatctaa agcagccata aacacgccaa 840181 tcgtaaacag gctgattgcc cacttttggc ttttctgctc tgttaatgct tcagacattt 840241 tcgtcaactc cttttagttc acttgaaata tattattcat tttaaatgaa ctaaatgtca 840301 aataaaaaaa gcctgctccc gcagtttgcg gatgacagac ttactgattt attctttttt 840361 cgcattctct aatgctcttg aaaggataga cagcccttcg taaacagcct gcttttcttc 840421 aggggacagc agctctaatg aacgcttcaa tttcaggtgg cccttttcat acaaaccccg 840481 gaaaatcttt ttcgcattct ctgtcaactg aacaactaca gagcggcggt cctcttcaga 840541 atgtgagcgt ttgacaaatc ctgatttttc aagccggtca agcagcccag ttgtattgga 840601 cagggaagcc cccatttttt cagcaatgtc gctcactttc aatgttccat ggttgtttaa 840661 tagcatcagc accttcattt gcggcatgct catatccagt ttcatccact cggacacatc 840721 accgagcccg gcggacgtta agactttcat atagagcacc catatttccc gttcctccga 840781 tgaaagaatg ttttcgttta agactgttgt atcgtgtaaa ttatattcca tttcatcact 840841 tcctcatcat tcactcctct taccatatta ctcgattttc actcctgaaa gaaagtgagc 840901 agaaaccgca tgcgggactt tgtccgaaaa ataacggtag tgtataatga gttggagatt 840961 attgggggag aggatcgaac tagaatatga ttggagagac cattgctgat taaaaagaat 841021 gctttatcaa tattaaaaat cgtttttcct attgctgttt tgctatttgt tatttatcaa 841081 tcgaaaaaag aactgacaaa tctgtcattc aaacgtacgc tcatggtcat caacggactg 841141 gaacgaacgg atttattcat gcttgtgttg atcggcttgc tggctgttgc ggctatgtcg 841201 ctgtatgatt acgtcctgaa gtactcactg cgcctatcga tcacaaacgg aaaagttttc 841261 agggtttcct ggatcgccaa ttcatttaat aatgtgttgg gattcggcgg tttagccgga 841321 gtcgggttaa gaatgatgtt ctataaggag catacgaaag accataaggc actcgtgaaa 841381 ggaatcgcct ggctcacatc atctatgctg ctcggattat ctgttttcag cattttcgtt 841441 gctgcgagag tgctgccagt tgatgaagtg attcatgaga agccttggct gtgggcggtc 841501 gttatcggtt ttgcactgat attgccgtta tctttagcgg tgtccaaaat aaaagaccgc 841561 aaagctgggg acgaagagaa tgcggataaa gtgaaaaatc cgattttcgc atatattgga 841621 gcttcagttg ttgaatggct catggccggg accgtcatct attttgcttt gttcgctatg 841681 ggcattcatg cagatatcag gtatgtgttc ggggtgttcg tcattgcggc gatcggagga 841741 atgatcagcc tcgtgccggg cggcttcggc tcgtttgacc ttttattttt gctggggatg 841801 gagcagcttg gctatcatca agaggccatc gttacttcta ttgtgttgta caggctcgcc 841861 tactcattta tcccatttat cttgggactg ttctttgccg ccggcgacct gacggaaaat 841921 acaatgaagc ggctcgaaac gaacccgcgc atcgcaccgg caattgagac gacaaacgtt 841981 ctgcttgttg ttcagcgtgc ggtattagtg agaattttgc aaggctcgct ttcccttatt 842041 gtgttcgtag caggtctgat tgtcttggcc tcagtttcct tgccgattga caggctgacg 842101 gttataccgc acattccgcg cccggcgctt ttgctgttca acggcctgtc cttaagctca 842161 gcgctcattc tgctcatttt gccgatcgag ctttataaac ggacaaaacg ttcctacacg 842221 atggccatta cagcgcttgt cggcggcttt gtgttcagct ttttaaaagg gcttaacatc 842281 agcgcgatat tcgtactgcc gatgattatc gtattgcttg tgctattgaa aaaacaattt 842341 gtccgcgaac aggcatccta tacactggga caattgatat tcgctgtggc gctgtttact 842401 gtggcgctct ttaactacaa tctgatcgcg ggctttattt gggaccggat gaagaaggtg 842461 ctgcgtcacg aatatttcgt ccacagcacc tcgcatatta cacatgcaac catcatggcg 842521 atcatcattg tgccgctgtt cttcttgata tttacagtgg tctatcataa gagaacgaaa 842581 ccgatcggag agaaagctga ccctgagcgt cttgctgcgt ttctcaatga aaaaggcggc 842641 aacgcgctga gccatcttgg ttttcttgga gataagcggt tttatttttc tagcgatgga 842701 aatgcactgc ttctgtttgg gaaaatcgcc agaaggctgg tcgtgctcgg cgatccatct 842761 ggccaaagag aatcattccc gctcgtgctg gaagaatttc tgaacgaagc gcatcagaag 842821 ggattcagtg ttttgttcta tcaaattgaa cgagaggaca tggcgctgta tcacgatttt 842881 ggctacaact tctttaaatt gggtgaggaa gcatatgtag atttaaatac atttaccttg 842941 actgggaaga aaaaagccgg ccttcgggca atcaataacc gctttgagcg ggaggagtat 843001 actttccatg tggatcatcc cccattttct gatgcgtttt tggaggagct gaagcaaatc 843061 tcagacgaat ggctcggctc gaaaaaagag aagggattct cgctcggatt ttttgatcct 843121 tcctatttac agaaagcgcc gatcgcctat atgaaaaatg cagaaggaga gatcgttgca 843181 ttcgcaaatg tcatgccgat gtaccaggaa ggagagatat cggtcgatct gatgcgctat 843241 cgcggcgacg ctccaaatgg cattatggac gcattgttta tccgtatgtt tttatgggca 843301 aaggaagagg gctgtacgtc atttaatatg gggatggcac ccttggccaa tgtcggcact 843361 gcctttacat ccttctggtc cgaaaggttt gccgctgtca tttttaataa tgtcagatac 843421 atgtacagtt tcagcggcct aagagccttt aaagaaaaat ataaaccgga gtggcgaggg 843481 aaatacttag cgtatcggaa aaacagatct ctttctgtca ccatgttcct cgttacacgt 843541 ctgattggca aaagcaaaaa agactccgtc taataagacg gagtcttttt ttatttcgtt 843601 tttaagaagt aggtttcaat atcatcaagc aggtagtttg cggctttaat tccgcctgcg 843661 gttgtccata cgacgtcatc gacttcatgt gcattacctg acttcacggc cttcaggttt 843721 ttccatagtg aactgcttgt ccactgattg gcccattttt cattttcttt tgcattatcg 843781 gctttataag tgaaataaaa cagcacatca gcatccatat caggaataga ttctttactg 843841 tcggttgaga acgtaaattg gtccttttgt ttcttaaaca gttccacttg tttttcaggg 843901 cgtttgaagc caagctggtc taaaataatc ccaggaaatg aatcggtata atagattctt 843961 gattcaccgg ataaaaagcg tacgactgaa acggttttgt ttgtctggtc gcccagcttg 844021 ttttttaaat cagaaacacg tttatcaaaa tcggcaatga cttccttgcc tttgtccgcc 844081 ttattcaccg cgttggcgta tagagtcagg ttatccttcc agttcccggc caaagattca 844141 gcaaaaacag tcggcgcaat cgcatttaac tgatcataaa ttttttcctg gcgcactttg 844201 tttccaataa tcaaatcagg ctttaattct gcgatggctt ccacattcgg ttccgtttca 844261 agaccgacgt ttttaacacc tttcatgtca tctttcagat agtcatacca cgggtcgccc 844321 ttccatgact ttacggctcc gaccggctta atgccaagcg ctaagagcgc ctctgttcct 844381 tcattagtta aaacaacaat ccgttttgga ttggcgggga tgttgtctga tgtccccatt 844441 gcatgtttga ccgttcttgt tttgctgctt gacacctcgc tgttgcttga actttctgaa 844501 ctattacagg cagaaagtac cataacggcc attaaaaata cgaatagcat gctgatatgc 844561 tttttcatct ttttcctccc aatattgaaa ttcattatca tttagatcat aataagcagt 844621 gttaagagtg tcaatcccta attgaggatt attctcaaaa acaaacatta catagtaaat 844681 aactaggaga attagatcat gatctgcaaa aaggcatctt caaaatggat tgtgttagta 844741 tgtctgattt tcattttact gacggctgtc tgcgcaagcg tcgtgtatgg ctatacaggt 844801 acgtcatgga gacaggtcta tcaggcgttt acttccttca atggaacaaa tgagcatgtc 844861 atcatcaagg atgtcaggct tccgcgcgct ttggttgcga cagtcgtcgg cgcctcgctt 844921 gcagccgcgg gcgctctcat gcaggcgctc acaaaaaatc cgcttgcgtc accggggatt 844981 ttcgggatta acgccggtgc aggttttttt attgttgccg gatcgttttt tctgcatatt 845041 cagtcacctc aggcattagt atggagctcg tttctggggg cagcatttac cgctgcgatc 845101 gtctatgcag caggctcgct tgggagggaa gggctgacgc caatcaaact gacgctggcg 845161 ggagctgcca tggcagccat gttttcttct ctgacacagg gcttgctgtc tgtcaacgaa 845221 ctcgagcttg cccaggtgct tttttggctg actggctctg tgcagggccg gagtctggat 845281 ctgttgatga cgatgtttcc atatgcagcg gcagcgctgg taatctgctt ctttctcggc 845341 caaaaaatta atctcctcgt tatgggagaa gatgtggcaa aaggactcgg ccaaaaaaca 845401 ggcctgctga aatttgtgat ggcgctttgt gttgtcatgc ttgcagggtc cgctgtcgcc 845461 attgccgggc cgatttcttt tatcggcatc attattccgc attttgcccg ctttgtcgtt 845521 ggtaatgatt atcgctgggt tctgccattt tccgctgttt tgggtgccat tttgcttgtt 845581 tgcgcggata tcggtgcgcg atatatcatt atgcctcagg aagttcctgt cggggtcatg 845641 accgccatca tcggaatgcc tgtgtttgtg tacatcgcaa gaaggggggc gaagctatga 845701 aacttcgttt tggcgttact gcggctgaaa agaaagcatg gatcgtcttt ttggttttac 845761 tggggttaac agctgctgta ctcatcataa gcgctggtct cggacaaagg tttattcctc 845821 cctgggatgt agcaaaaaca ttctttggtg caggttccaa gctggatgaa ctgatgatca 845881 tgtcgttccg catgccaaga attttgacgg ctttatgcgc cggtgtctgc ttggcagcgg 845941 caggcgcgat attgcagggg ctcgtcagaa accctctcgc atctccggat attatcggaa 846001 taacaggagg agcggcggta gcggtcgtgc ttttaatgat gttcttctca gaccgcagca 846061 gttcacttac gatcagtctg tcatggcttc cagcagccgc atttatcggc gcatcggctg 846121 tcgggctcat cgtctattta ctggcataca aaaatggcgc ctccacattt cggctggtgc 846181 ttatcggaat cggattttca atgtcggcgc aggcgatgac taccctgttg atgatcaaag 846241 gcccgattta ccgagcatca caagccaatg tgtatatcac tgggtcagtt tatgggtcaa 846301 actggcagca tgtaaaaata gctattatct tatctgtcat tctcttattc atttgttttg 846361 tcgcgctaaa aaatatgaat atacaggtgc tgggtgaaga tattgcggcg ggtgcaggaa 846421 gcgctgtgca gcgaaatcgt tttttcttgc tccttttgag tacggctctt actggttgtg 846481 cagtttcagt tgccggcaca atcggttttg tcgggctgat ggcgccccat attgcaagac 846541 ggcttgtcgg ctcatcttat ggcgcgctgc tcccagcgtc ggcacttatt ggagctctgc 846601 tcgttttaac agctgatatc gtcggcagaa ccttatttgc tccggtggaa gtgccggccg 846661 gcgtctttac agcggctatc ggcgcacctt attttattta tttgctctat aaaacaagaa 846721 attcttaatc gttacaccca ttttcttaaa aaagaaaatg ggtttttttg ataatgactg 846781 aagattcgta attatttttg ctatactgac agagacattg ataaagaaag ggcggcagat 846841 gaatgaaaga agcagaggta ttaaaatatg aagcatttac aagcagtccc ggcaaaggaa 846901 accccgcagg cgtcgttttg cagggagacg attatacgga agacgagatg cagatcatag 846961 ctgaacgtgc cgggtattca gaaacctcct ttatccgaaa aagcgagtcg gccgatcttg 847021 aactccgtta ctttacccct ggacacgaaa tgaatttgtg cggtcatgcg acagttgctt 847081 ctctttacgc attatgtgag aaaggaatgc tggagagcgg taaaacgtac agcatccaaa 847141 cgaaagcggg tatcctgcct gtgaagattt ctgaaaaaga tggccgcatt catatcacgc 847201 ttgaacaggc ctctccgcaa ttcaaaccat ttacaggcga tcggaaaaaa cttgcggacg 847261 cactgggtat caccgatgaa gattttcatg aagaccttcc gattgtgttt ggcagcactg 847321 ggatatggac agccatcgtt ccgcttaaat cattggaggc ttccaaaaaa atggtgccag 847381 ataacaaaca atttccggaa gtgttagttg atctgccaaa agcttcagtc catccgttta 847441 cctttgaaac cgtccatccc gacagcgacc tgcacgggcg ccacttttca tccccgtatt 847501 cgggaacgat tgaagacccc gtgaccggca cagcatccgg cgtgatgggg gcttatatga 847561 aacattatgg caatgccgag cagcataaat ttatcattga acaagggcag gaaattggaa 847621 aagacggaaa agtggagatc gaaatgaacg aagccggcgg ccatgtgaaa gtgaacatga 847681 caggaacagc cgtttactca gaaacccgta ttcttaaaat ctaatacgga tgatggttta 847741 caaaaagatg cactttccgt tatcattatg aaatgataat cattttcaat tgcataggaa 847801 ggtgagacgg tatgcctcaa accgaacaaa tacatcagca ttcagtactg agggacatca 847861 tacgcagcag aagatcgatt cgaaagttta aacaagagcc agtaccttca gcagtcattc 847921 ttgacatgct tgaaacggca aaatatgcgc caaatcacag agtgacagag ccatggagat 847981 ttatttacgt ttccagtgag acaggtaaag cgaacctcat taatacattt gcagcgttct 848041 ctaagaaatc caagccggat atgacagagg aaaagcttca aaatttcaaa aacacacttg 848101 ggcgcgttcc gggatttctc ctcgtcgtgt ttcaggaaga tgaaaacgaa agagcgcggg 848161 acgacgattt tgcggcaaca agctcgttga ttcaaaatct tcagcttctc gcttgggaaa 848221 aaggaatcgg catggtttgg aaaagcggaa aaatccttta tgacaaagaa gtccatcagg 848281 cctttggttt acaggataat gagcgtttcg ccgccatcat acaaacaggt tatcctgacg 848341 aggcgccgga agtgaaaaaa cgcacaccga tccgcgaccg attcactgaa atgtaaaaaa 848401 ccccttgtct caaacggaga caaggggttt ttcattaacg agatttcttt ttcgctctgt 848461 tgtcggctgc tttcgcacgc tcttgcgctt cgcggtcatc tgcatcagca agctcggttg 848521 aatattcttc gtaaacgccg tcagtttccc tttttaaggc atcgggaact tgtggaagct 848581 tttgtttgtt tttatcacgg tttttgtgga tatgatttct gcccatatca aattccccct 848641 aaaaagtgat atcaaacaaa tatagtattt ggttttaagg ggctatgtat tcctacttcc 848701 gcttagcagc tttttccgct tttttaaatt cgcctgaata aagaacttcc tgcatttttt 848761 tcaggttggc gccttgctgg tgcttctccc tctttttttc cataaaaagg acctccttca 848821 accatgttat tcttaaggtt gacgcttcct gctgttttta tacagtcttt cggtccgcta 848881 tcagctgtga gagtgcaaat tcaagatccg aatatgtaaa acgaaatcca gaggttatcg 848941 cttttttcgg aagagcgcgc tgtcctttca caatcaaaag actcatttca cccaatgctt 849001 ttgataaaaa gaattccggg acggggagcc agtgcgggcg gtgcttcacc cgtgcaatcg 849061 tttttccgaa ttgcttcatg tccacaggat tgggcgcggt gacattcatt gggcctgaga 849121 tgccggcgtt ttccaccgca tatcggatca tctgggccgc atcctcgaca tgaatccatg 849181 acagccactg ccttcccgtt ccgatcgttc cgccggccag aaacttatag gggagaatca 849241 tgagcgggag agcgcctttt tctccaagca tcacgccaaa tctcgcataa actgtccgga 849301 tgcccatcgc ttcaatatgc tgtccttcct tttcccacag gtgtgcagta tggctgagaa 849361 aatcctcatc tgacgttgca gaatcctctg tgaaagtttt ctcaaggctt gtgccgtaaa 849421 tgcccacggc actggcttgg atcaatgtct tcggcttctc cttctgtttc tgaataagcc 849481 gctgcacttc acgcgtcgca ttgatacggc tggagagaat gtgctgcttc gttttttctg 849541 tccagcggcc aaaaatcgat tttcccgcaa gatttatcca gacatcaata tgaggaagtt 849601 cctgctccgg tgcggctcct tccgacagcc attggacata tgtcatattt ttttgttcag 849661 tttcccttgc gtttcttgat aaaatataaa catggtgtcc ctggcgggta agaacgcctg 849721 tcagatgctg gccgagaaaa ccggttccgc ccgtcattgc gatattcatg aacatctctc 849781 ctcatcgttc taataaatat actttacctc attgtaataa aagaaaacgc gtttcaggcc 849841 tgagaaggga gattaagatg ccgtttatta caaaaatatc aacgcaaaaa aagaatacgg 849901 aacgcttcaa tatttttctg gatgataaat acgccttcag cgtggacgcg gatgtgctcg 849961 tgaaatttga gctcaagaag ggaaaagaac tcgatgatct tgacatcatt gagattcaat 850021 acggcgatga agtgaagaaa ggcttcaacc gtgcgcttga ctttttatcc tatcgaatgc 850081 ggtcgacgaa agaggtcgag gatcacttaa agaaaaaaga aacctcgccc cccgtcattg 850141 cggaagtcat ccataggctt aacgattaca agtacttaaa cgaccaggaa tttgccgcag 850201 cctatgtcag cactcacaaa aaaacaaacg gaaaaggccc tgatgttttg ttcagagagc 850261 taagagcgaa gggaattgat gacgatacaa ttaaggaggc gctaagttcc ttttcctttg 850321 aagatcagac aagagaagcg gtcaagcatg ttgaaaagct tctcaaaaaa gataaaaagc 850381 tttcgacgaa agaactcaaa cagcgcgccc agctgcagct tcagcgcaag ggcttctcat 850441 ttgatgttat cagcgcggcg atggatcaga ttgaatatga aaatgatgaa gacacagaga 850501 aagaagcgct gcgccttcac gcggaaaaag cgtttagaaa ataccgctat gacggctcat 850561 atgaaagcgc catgaaggtc aaacaatttt tattccgcaa aggattctca ctcgatttaa 850621 tcgagcaatt actgcaggaa gaggagtact gaaatggaga aacgatacag tcaaatgaca 850681 ccgcatgaac tcaataccga aatcgcatta ctttctgaaa aagcaagaaa agccgaacag 850741 catggaatca taaacgaact ggcagtgctc gaacggaaaa ttacgatggc aaaagcatat 850801 ttgctgaacc cggaagatta ctcaccggga gaaacatatc gtgtggaaaa cactgaggac 850861 gagtttacca tcagttattt aaatggcgtt ttcgcatggg gatacaggac ctcttcccct 850921 cagcaagagg aagcgctgcc aatctcagta ttgcaagaaa aagaataaag cgtaacagga 850981 ggctgatgat cagcctcttt ttgtttgcag cacatttaca cgaattctta aagaaaaaat 851041 cattgaattc acttgaaaaa tcttttaaga tgaaactcgt tgttttttaa aatcaaagga 851101 ggcgatgacg ttgagtatca aaaacccatc tgtaaaattt attatatttg ttcttatgat 851161 ttgtacattt tcaatcggct atacagaata cgcggtgatg ggtattttga cgtcgattgc 851221 caatgacttt catatacagg tttcatccgc agggcttctt gtcacggctt atgcggcaag 851281 cgtttgtttg acagggccgc tcgtcaccat catttccgtc aagcttccga gaaagcctgt 851341 gcttcttggg ctgatggcga tatttatcct ttccaacctg atgagcgcac tggcgccgaa 851401 ttttgcggta ttggccattt caagaatttt atctgcgtcc attcacggcg ctttcttcgc 851461 gattgccatg gtattcgcaa gtgaaatggt tccgccggaa aagcgtgctg cagctgctgc 851521 ttcaatgaac ggcggactga cagtggctct aatgcttggt gttccattcg gctcttatct 851581 cggagatgtc ctgaattgga gagcggtgtt ttccatcatt acggcacttg gtgtcatcgg 851641 atttttaggc cttatggctg ccgtgccgaa cagaaaacca aaagtgatcc caatgcttat 851701 gaatgagtgg ggtgttttta aacacaaaca agtgctgttt tccttcgcga ttaccatttt 851761 aggctattcc ggtgtcttta tcgcctacac ctttatcgaa cccattttga ggcattcagc 851821 cggattcagc acggttggca ttacaggtgc tctctttgcg tatggattgg gaggcgttgc 851881 cgggaatttc tttgctggaa aggtaccgct gcctttgctg actcggacga tgatcggcgt 851941 aatgatcggt ttaatcggtg ttctggctgt atttccttac atcgccattt acccggctgc 852001 agccattgtg gcaacgttcc tattcggggc atgcgcattc ggcacgccgc ctcttctgca 852061 aacaaaggtc atttcctcat ctgagggcgg cacaaccatt gccgcagctg tcagcgtatc 852121 agcatttaac cttgccaatg cccttggtgc atggatcggc ggaatgattt taaacggaac 852181 aggctcttat tcctggctgt ttgcaggagg tgcgcttatg accgcatgcg gacttgtgct 852241 ttctaccttc gcacacttat cagaaaagaa gagcgtctac gaatatcaag tcaataaagg 852301 gtaaaaaaca gctgcagtgt atgcagctgt tcttctttac cgtttgcctg aggctctcat 852361 tctttcttga ggatgctgat tgatagatcc gtcagcacgc tttgaagcat agtcgtcctt 852421 tgctctcggt tcaccctgaa atttgttttc gttttcgtaa ggaaatcctt tttctttatt 852481 tcggaccatg tcatatcccc ctaggttcga gatcaaaaag ttgcgtcttt tcagatgaag 852541 acgtaaggtt agtatatgga gaacaccacg taataaagcg ttattttttt cctgaagaaa 852601 ggagactgca cacatgaata tgtacattga gaaactgact aatctgcttc tggaaaagaa 852661 cgagatgatc agctatatac aggcaaaaac gtgggtggaa ttgttatgga gcgatttcga 852721 agcaacctac gcaaaagccg gacacgccta tcaaggtgaa aaaatgactg aaaaaatcgt 852781 cacacaatgg attgaaaact atggcggcca gctccacctt tttcaaagct cccgtaacga 852841 cgtgaatgat tacttaaatc aaagcagagg ccttttgcat taaaaacctg ccgttaacga 852901 ccggcaggtt ttttcatttt cttaaaatta ccttaacagg aagaaatcat aaacaaaaca 852961 tgtttcacca gcctgtcaat cagggaatac cacttatatc ttgtcaaaat gcgaggagga 853021 gctttatatg aaaaagaaac aagtaatgct cgctttaaca gctgccgcag gactgggttt 853081 gacagcactt cattccgctc ccgcagcaaa agctgcgccc cttcacgaca tatctgtcag 853141 catgccatca tccgatactt acatcataaa agcaggaaag ctgaatgtcc ggactgagcc 853201 aaatcatgaa ggtgatattc tcggcactgt atcatcagaa caaaaggtaa aagtcgatag 853261 gttcgtaaat gccgattggg ctcaaattca tttcaaagga aagaaagcat atatttcaac 853321 tcacttttta atgaaaaccg caagccaagc gaaaacaacg aaacagacag ccttctatac 853381 accgacgccc gaaaacggaa aagctaagca gctctcatct ggaacagagg tgacaatact 853441 tgggtgggga ttcagtgaaa acggcggatt tgacttcact tgggcgttcg tggattatgg 853501 cggagttaaa ggctatattc acacaaagga tttacaaatg cgataaaaag gcaggccgag 853561 gcttgtcttt ttgcctatgc atgaaacatt tcttctttct gcacgtaaca atgagaaagg 853621 agatgatgat atgacgggtt tagtcggcgg agggcttatg atcattgcgg gcatactgat 853681 caaactgttt cctcccaaat cgatcaacag tgtgtacgga tacagaacga gacgctcaat 853741 gtcagatcaa agattatgga atgaagcgaa ccgttacagt gcatcattaa tgatcctgtc 853801 aggcttggtg attgcgggaa tgggtttgct gctgggatca aacttgttta ttcttcagct 853861 tatcctgctg attgccgcct gtgtcataac atttatgcta acggagaaaa ggctgaaaat 853921 catgacgcac agtcaaggag gagatagaag tggacggagt taaatgccag tttgtcaata 853981 cgaacggaat cacgcttcac gttgcagccg caggacggga agatggcccg ttaattgtcc 854041 tgctccatgg atttcctgag ttttggtacg gctggaaaaa tcaaatcaaa ccgcttgttg 854101 atgcgggtta ccgggtcatt gctcctgatc agcggggcta caatctcagt gacaaaccgg 854161 aaggaattga ttcgtatcgg attgatacat taagagatga tatcatcggg cttattacgc 854221 aattcactga tgaaaaagca attgtcatcg gtcatgactg gggaggagct gtcgcatggc 854281 atttggcttc cacacgcccg gaatatcttg aaaaactgat cgcgatcaat atcccgcacc 854341 cgcacgtcat gaaaaccgta acgccgcttt atccgccgca atggctgaaa agctcgtata 854401 tcgcatactt ccagctgccc gatataccgg aggcatcact aagggaaaat gattatgata 854461 cattagacaa agcgattgga ttatccgacc gtcccgcgct ttttacatcc gaggatgtca 854521 gcaggtacaa agaagcgtgg aagcagccgg gcgcgctgac agctatgctg aactggtaca 854581 gagccctcag aaaaggaagc ttggcagaga aaccctctta cgaaacagta ccttaccgaa 854641 tgatctgggg aatggaagac cgctttttga gcagaaagct tgcgaaagag acggaaaggc 854701 attgcccgaa tggacatctc atctttgttg atgaagcttc ccattggatt aaccacgaaa 854761 agccagccat cgtcaatcag ctgattttgg aatatcttaa gaaccaataa gctaaaattt 854821 ctctccatcc gtctgtcata atggcagact ttttctgtgc gttttttttc atagtctgtt 854881 ttaaacatga caaaataaca ttaaaaatca tgaatgtcac cataaaattg taacaaaaaa 854941 caggtttaaa cgactttaaa aaaaggaata gccttactga agatttgtgt aaaactcccc 855001 taaggcaata cttaaaaaga ataataaaaa gaaggtgcct taatgaagca aggattaatc 855061 tcgattatta tcccgtctta caatgaaggg tataatgtta aactcattca tgaatcttta 855121 aaaaaggaat ttaaaaacat tcattatgac tatgaaatat tcttcataaa cgacggaagt 855181 gttgatgaca cgcttcagca gatcaaagac ttggcagcga cgtgcagccg ggtaaaatat 855241 atatcttttt ctcgaaactt tggaaaagaa gccgcaattt tggcgggctt tgagcatgtt 855301 cagggcgagg cggttattgt catggatgcc gatctgcagc atccgacata tttgctgaag 855361 gaatttatca aaggctacga agaagggtat gaccaagtca ttgcccaaag gaacagaaaa 855421 ggggacagct ttgtccgctc actcttatca tctatgtatt acaagttcat taataaagcg 855481 gtggaagtcg atttgcgtga cggtgtcggt gacttcagat tgttaagccg ccaagctgtg 855541 aatgcacttt tgaagctgag cgaaggaaac cgcttctcaa aaggcctttt ttgctggatt 855601 ggctttgatc agaaaattgt attttatgaa aatgtcgaac gaaaaaacgg cacctccaaa 855661 tggtcgttca gcagtctgtt taactacgga atggacggcg tcgtttcatt taatcataag 855721 ccgctgagat tatgttttta tacaggcatt ttcatcctgc tgctttccat catttatatc 855781 attgccacat tcgttaaaat tctgactaac ggtatttctg tgcctgggta tttcaccatt 855841 atctcagcag tgttatttct cggcggagta cagctgttaa gtcttggaat aataggtgaa 855901 tatatcggcc gaatctatta tgaaacaaaa aaacgcccgc attatttgat caaagaggcg 855961 aatatcccga acaaagacct gcctgaaacg aacgaattaa aaagcatgcg gcgtctgaca 856021 aaaatgcact gaaaatacca agcgccattg gcagtgcttt ttttgcgtgt ctattatctt 856081 aaaagcaaga ctggagaatt catatgaaaa gaaaacatat catgatctat gcggccagtt 856141 tgctggtgtc cgttctggca cacgcttttt ttgtgaaaga atgggcggaa ggcaggtata 856201 tgacaggtcc gggtgacggg cttgcgcaaa tgatcgtatt taaaaaatta ttatttgacc 856261 aatatacaca cgggaatttt ttctacaatt attcattcgg acttggcggc ggcacattca 856321 gtcagctcgg ctattatttt tctgcgtctt ttctttttct tgctgtgtct gccgctgttt 856381 ggctgcttca agccgtccag ctgatcggag aaacggatac gcttttttgg gcagagtcag 856441 ctgtttttat cagtattttc aaattgagct tgatcatctt tacgtccgct tctgtttttc 856501 attatcttct taagcacagg gcggcatcgt tcacgggagc cgtgttatac ggcgtctcaa 856561 ttatttattt ccgtcacgaa gcgtattggg aatttttcac cgatacaatg gtttggcttc 856621 cgctgcttgt gcttggcgca gaaaaaatta ttagagagcg gcgtccggcg tggtttatcg 856681 ttgcgtgttc gctgacgtta atcaacaatt tttactttgc atacataaac cttatattca 856741 tcggaatcta tgtgctgttc agatggctga tccgtttgga accacatgaa gagaaaagat 856801 ggattcaaat cagattattt ctcgtttcag gcttcatttc ttttggcatc agtgcggcgg 856861 cgtttgtgcc ggtagtatac ggttttttaa acaacctgcg ccctccatac agccagaaaa 856921 tagagtggct caatttcgat gataatatct tattttcgag ccggatcatc attgtgccgg 856981 ccgcttttct gctgtttttg tttattattt ctttttacaa aaaccgtgtg tttcgtctct 857041 ttgccgggtt gagcctgctg tttattctgt ttcatttcag tccgtatgcg gcaagcgtct 857101 ttaacggttt ttccgccccg caaaaccggt ttgaatatgt tctggccttt accattgcgg 857161 gagcagctgc ggctggtttg tcacagctgt ctgaattgaa acggaaagaa ctgctcccgg 857221 ccgcagctgt cgtcctgctt ctttacttgt atcatatcca aaggtataag ctcgatatat 857281 ggaagcctgc gaatgaaagt attctattgc tcttactcat gacaatcgca gccttgtttg 857341 ctgcagcttt tgcgaaaaaa cgggcaaaaa tggctgtgta cggtataatc attctttctt 857401 cgctgtttgt cgccaactcc tatcaaaaat acgcgctctc agaaggcggc gatttggaca 857461 gtgtgacaaa agaatatctt acaagtgagg aatacagagg gcgggaatca tctgagctca 857521 tcagacgttt acagaaggaa gacgatgacc cgctcatgag aatcgactgg atgaacgggg 857581 tccgcaataa tacgccaatc atttacggat ttaatggctt cagcgcgtat tccagcattt 857641 taaacaaaga tctgctggcc ttctattgga atgatttaag catcgatatg ggcagggaaa 857701 gcgtcagccg ttacgcgtca ttgggagaca gggcgaattt atacagcctg ctttacggca 857761 aatattatat gaccgaaaaa acaaacgaag ccagcgtccc gtacggcttc aaaaagcatt 857821 tagaaacaga gcattatgca gtttatgaga atcagtacat gcttccattc gttaaaacag 857881 cggatgccat atacagcgaa agtgagctgg accgattgcc cgctcttgcg aaagaacagg 857941 cgatgctgaa aggaattata ttaaaagatc catcaggaaa aacggagcag acaccaaaac 858001 cgtccaattt gatcaccaag tcggacatca ccgcaaaaca agcccagtat caaaacgggc 858061 tgctaaccgt aactggagaa aacggaggag agctgatcat caccccgaaa cagccatcat 858121 ccgctccggg agactactat gtcagctttt atttgaaaag caaagcaaaa gacaaaggat 858181 ttacattaaa ggtaaatgat tatgtcacaa caaggaaatc gaacaaatcg atctataaaa 858241 ccggagtaaa taatataacg gtaagagtgc ctaaatcagg ccatatctca atcaatcttc 858301 cgaaaggaac ctatgagctg agaaacatag cgctctatga agaaaattac caaacgctga 858361 aaaacgctgt aatgcaaaat aaaacagaga aagcagacaa actgaattgg aacaaaaatc 858421 gactgacctt ttcctatcat ctgtcaaaag accagtacat catgcttccg atcccatatg 858481 aaaaaggctg ggagctgaag atcaacggaa aaacacagaa gatcgaaaaa gcggattatg 858541 cttttatagg cttcaaggcg caaaagggag acaatcacat tgagctgact tactatccgc 858601 catacttcaa aatatcggcg atcatatctc tcgtcagtct gctgcttgct gttttttata 858661 taagacgtaa aaagcccggc tctatataga gccgagcttt aattttttct gaagtttttc 858721 ttcgctgaat atccatcccg tataggatga acgaatcgtg agatcatggc cgatatgaac 858781 aattgcgaca aacggataat ggcctttgct ccgataacgc aggtcgataa atctcacctc 858841 ataatgatct ttaaacgtat ccacttccca ccggtatacc ggagaaaagg acagaaacgc 858901 cgcgatgtta tcatcctgct ttgccgcatg cattacatcg gtttcaggaa caggcacccg 858961 attaaatgta tccagaatca cgacatgtcc ttccatgctt cttcctacat agaaagcatg 859021 tgctgtcgtc actgcgattc gccattgcct gaatttcatc gttggagaaa taataatgct 859081 ttcgatctca tcatgaatca tctcatgaag cttccgttta attctcagct gcatgatcag 859141 gcgcaccaag tagtagccta ccaatatgat atataagctg agaaacgtga tgccgggact 859201 cccgcctgca taccaaatcg cgatagctgc cagatggctg ataaaaataa acggatcaaa 859261 cgtattaatc agcccgagcg caacccattt tttcgaaaac ggacgaatgg cttgtgttcc 859321 ataggcgttg aatatatcaa caaagacatg cagaacgact gccagcagtg tccacagcca 859381 caggtgcaga aaatcggcct gaggataaaa taaatacaga atcgccggga tgatgacaga 859441 ccaaaacaaa acggcgggaa ttgaatgggt aaatcctctg tgattcctta tataaacagc 859501 attgttttta agctttaaca cagtatcaat atccggagcc tgagagcccg caagcgttgc 859561 gatcataaca gcgtgagcca ttgccggatc tgatccgaca acaggatcaa gcgtcgcaat 859621 accgcccagt gcgatgccca taacgacatg tgtgcccgta tccataggtg acctccttgc 859681 agggtgatcc tgcacattca ctttgtaaga aattccccat tttcatatac ccaattttta 859741 aactgattca atcgttctca tatgtttccg ctttttcttt attactattt aatgtaacat 859801 attatcgtac tgtgccctta gtgtacaaca aaaaacagtc taaagaaaag cggggcgcga 859861 aagactgggg agaaacacat atgaacgtac ttgaagacaa attaaaacaa aaagacatac 859921 agcaatttcg cgatgattta atctcatggt ttgaacgaga gcagcgcgtt ttgccgtgga 859981 gagaggacca agatccatat aaggtgtggg tatctgaagt gatgctgcag caaacgagag 860041 tagagacagt gattccttac tttctccggt ttgtagaaca attcccgaca gtggaagcgc 860101 tcgctgatgc tgatgaagaa aaggtgctga aagcatggga agggctcggc tattattcgc 860161 gagtcagaaa cctgcaaagc gcggtaaaag aagtgaaaca ggaatacggc ggcattgttc 860221 ctccagacga gaaagatttt ggcgggttaa aaggcgtcgg cccttataca aagggagcgg 860281 tgctcagcat tgcctacaat aaacccattc ccgcggttga cggaaatgtg atgcgtgtca 860341 tgtccaggat tctatctatt tgggatgata ttgccaaacc aaaaacaaga acgatctttg 860401 aagacgccat acgagctttt atttccaaag aaaaaccatc tgaatttaat cagggcttga 860461 tggagcttgg agccttgatc tgtacgccaa aatcaccctc atgcctgctt tgcccggttc 860521 agcagcattg ctcagcattt gaagaaggca ctgaacggga gcttccggta aaaagcaaaa 860581 agaaaaagcc cgggatcaaa accatggccg cgatcgtact gactgatgaa gacggacaag 860641 tgtatatcca caaacggccg tctaaaggtt tgctcgccaa cctgtgggaa ttcccgaatc 860701 ttgaaacaca aaaagggatc aaaactgagc gtgaacagct cattgctttc ttagaaaacg 860761 aatatggcat acaagctgat atcagtgatc tgcaaggtgt agtcgagcat gttttcaccc 860821 acctggtatg gaatatttca gtgtttttcg gtaaagtaaa acaagtgtcg gataccagca 860881 agctgaaaaa agtaacgaaa gaagagctcg aacaatttgc gttcccggtg tcacatcaaa 860941 aaatctggaa gatggcagga gaagcagccg ccatctcggc tgctccgtaa accattctta 861001 atcgtaagag acgcgcgtgc cgtggctgta gtccgcttca ttgcgcttca ttccgccgcg 861061 cgcttcaatt tcttgcgtta attcccggta ttttgattgg ccttcttcgt tcaaataagg 861121 cataatttgc tgaaaggcat gatgaaaata agcgagttca ctgttcttcc aatctttttt 861181 ggaaaccatg ttcaattcgc tcatatcacg tccgacatac ataacagaag acccccttta 861241 aagttcttgc cattattgtt tgtggaaata aaagaactat acgctacaag gagatgagga 861301 aaaatggaac aaaataaatg tgcactcgta acaggaagca gccgcggtgt cggaaaagcg 861361 gccgcgatca gacttgctga gaacggctat aacatcgtca ttaactatgc acgcagcaaa 861421 aaagcagcat tagaaacagc ggaagaaatc gaaaagcttg gcgttaaagt gcttgtcgta 861481 aaagcaaacg taggacagcc tgcaaaaatc aaagaaatgt ttcagcaaat tgatgaaacg 861541 ttcggcagac ttgatgtttt tgtcaataat gccgcttcag gagtactaag acctgtcatg 861601 gaattagaag aaacacactg ggactggacg atgaacatta atgcgaaagc attgcttttc 861661 tgcgctcagg aagctgccaa gctaatggag aagaacggtg gcgggcatat tgtcagcatt 861721 agttcattag gctctatccg ctatcttgaa aactacacca cggtcggtgt atcaaaagca 861781 gcgttagagg ctttaacccg ttatcttgcc gttgagcttt caccaaaaca aattatcgtc 861841 aatgctgttt caggcggagc gatcgacaca gatgcgctga agcacttccc gaatagagaa 861901 gatctgcttg aggatgcgcg ccaaaatacg ccggcgggac gcatggtcga aattaaagac 861961 atggttgata ctgtggagtt tctagtgtct tccaaggctg acatgatccg cggacagaca 862021 attatcgttg acggcggacg ctcactgctc gtttaaaaat ttttaaaaaa gaggaatagc 862081 tatacgatca cctgcacatt ctaatgaccg tggaggtgat aacaatggct aactcaaata 862141 acttcagcaa aacaaacgct caacaagtta gaaaacaaaa ccaacaatca gctgctggtc 862201 aaggtcaatt tggcactgaa tttgctagcg aaacaaacgc tcagcaagtc agaaaacaaa 862261 accagcaatc agctggacaa caaggtcaat tcggcactga attcgctagt gaaactgacg 862321 cacagcaggt aagacagcaa aaccaatctg ctgaacaaaa caaacaacaa aacagctaat 862381 cactgaaaca gaaaaaagca cttcatcttc gggtggaagt gcttttttct gtttgaaaaa 862441 cgacaaaact tgtggaaggt ctacagaatg agtcaaaggg tttgctttat ggagatcgaa 862501 atgattaaag gaggaaatgt ttatactttc atcaggctga aggaggaacc gatgaccgaa 862561 tttgaaaagc tggtaagtga acagatgaaa acgatggata agcttctcga tctccaatca 862621 gagctcgacc gctgcaaaca aattgaggcg gaactccggc atttggaaag ggatgcaagg 862681 ctgcgtggga ttcaggctga aattgcggta aaacggaaac accttgccga tatacaggat 862741 atgtttcaaa agcagacaga gcaggtcatt cgttcatatc gcagctcaga aaagccgtct 862801 tcctttgtgt agtgcaggaa tgtgccattc cccggccgga atggctcttt tattttcatt 862861 tttcaatttg taacgttata ataggtaaaa gacgttgtcg gtaagcaaat ttggacatac 862921 taactgtagg gctttataga aagtagggga gaaatatggg ctatcccaag gaaggagaaa 862981 ccattcaaat tcacagctat aagcacaacg ggctgattca tagaatttgg aatgagacaa 863041 caatcttaaa aagtacagaa atgtgtgtca tcggagccaa tgaccggacg atggtaaccg 863101 aatcagacgg ccggacatgg ataaccagag agcccgcaat ctgttatttt cacgcaagac 863161 aatggtttaa tgtcatcggg atgctgaggg aagacggggt tcattattat tgcaacatca 863221 gttctccgtt tgcctatgat ggcgaagcaa ttaaatatat tgattatgac ttagatgtta 863281 aggtttttcc tgacatgacc tacaatattc tcgatgaaga cgaatatgat gatcatcgga 863341 aagccatgaa ttatccaaaa gaaatcgaca gtattttaag agactactta aatacgctgc 863401 tccattggat tcaccagcgt cagggaccgt ttgcgcccga gtttgtcgat atgtggtatg 863461 aacggtattt gcgctataca aaataatggt tacgtaaaaa cctgttgcgg ggtacaacag 863521 gtttttcaca tgggctcaca cacatcatga taaagagaga gggggaatca accgtggggg 863581 ttatgaaacg ctacatgcaa ttcgtcaaac cttataagaa gcaaattttc gttacagtgt 863641 taatcgggat cgtaaaattc tccattccgc ttgctctccc attgcttctg aagtacgtag 863701 ttgacgacat tattcaagga ggcggcacgg ccagtgacaa aaccacgtca ttgttcacga 863761 ttatggcgat catgttcgcc ttatttttaa ttttgcgccc gcctgttgaa tattaccggc 863821 aatattttgc ccagtggact gccagcaagg tgctttatga tataagagct aagctgtttg 863881 accatataca aaaactgagc cttcgttttt acgcgaatac aagaacaggg gaagtcattt 863941 cccgagtgat taatgatgta gaacaaacaa aggatttcgt catcacaggg ctgatgaata 864001 tatggctcga tatgctgacg attttgattg taatctctat catgctcaca ctggacgtta 864061 aattaacgct gatctctatc gttttattcc cattatacgg aatatcagtg aagtattttt 864121 acggccgttt acgaaagctg acaagggagc gctcacaggc tcttgctcaa gtgcaggggc 864181 atttgcatga acgcattcaa ggcatgcctg tcatcagaag ctttgcgata gaagatcatg 864241 aacaggctca atttaatgag aaaaacggtc atttcttaga taaagccatc cgccacacga 864301 attggaacgc gaaaaccttt gcggtcgtta ataccattac agatttggcg ccgctcatcg 864361 tcatagcgtg cgccgggtat tttgtcatta atggaccgct gacagtcgga acaatggtcg 864421 cgtttgtcgg atatattgac agaatgtaca accctgttag aaggctgatc aattcctcta 864481 caactttgac acagtcaatc gcatcaatgg acagggtgtt tgaatttatt gacgagccct 864541 atgaactcac tgacaaacca aatgcgataa aggccgatca gattcgcgga ggagtggagt 864601 ttcaaaacgt ttcgtttcaa tatgagaagg acaaagaaaa tattcttcat gatgtatcct 864661 taaaagtaaa tagaggagaa actgtagctc tcgtcggcat gagcggagga ggaaaatcaa 864721 cgctcgtcag cctgatccca agattttatg atgtaacaag cggcagactg ctgattgatg 864781 ggacggatat tcgcgattat gaagcaagaa gccttcgcaa ccaggttggt atggtgcttc 864841 aagatacctt tttatttagt gaaacgattc gggaaaatat cgcgatcggc aagcctgatg 864901 ccacacttga agagataatc gaagccgcca aagctgcaaa tgcccatgaa tttatcatga 864961 gttttccaga aggatatgag acccgggtgg gggaacgagg cgttaagctt tcaggcggac 865021 aaaagcagcg gatctcaatt gcgcgggtat tcctgaaaaa tccgccgctc ctcattttag 865081 atgaagctac atcagctctg gatttggaaa gtgagcatta cattcaagaa gcgatggaca 865141 aactggcgaa ggatagaaca acttttgttg tcgcccaccg tttatcgaca atcacccatg 865201 cggataagat tgttgtcatg gaaaacggga caatcattga aatcggaacc catgatgaac 865261 tcatggacta tgagagccaa tacaagcact tatttaccat tcaaaatttg aactaaaaca 865321 tcaatcttat atccttttaa cgaaggatat aagatttttt tgtatataaa aaaacccggc 865381 tgtttaaccg ggttactctt ctgtttctat ttcgcagtct ttcggatgat acgtttgaaa 865441 acttgtgata agtgtttcta aatgttcaag ctgctcgcga tattccacgg cgcttgccat 865501 aatattgagc atgttgtaat caataagctc ctcatccgta ttctgctgat tttttaaaaa 865561 tgactttgtt aaaagctgct tataccggat gccttcttca accgcgtcat catgcggctt 865621 gatttttccg acaaacctca tcaaaatccg ctcgtgccag taaagcaggt aatcaagttc 865681 ttcagtcaat gtttcctgaa actcttccgg catatgatag atctcgtttt ccagacgatg 865741 cagcttcttc aatgtatcaa gcgcccgatt tgcagtaata atggcctgtc tgaacaggac 865801 aagctttctt gatttcacat aagtcgtttt cttaaagtaa cttctttctt ctttatatag 865861 aagatatgtc tgatcaagct tgatcatttt ttctttcagt ttttcaatat cctctttcaa 865921 aatcgaatgc tctgtcgact gccgcatgga caatctgatc cacttcataa tttcttcggt 865981 gttttcgacg gtattatgaa tcagctttgt ttcgtactta ggaggcaaaa acacaaggtt 866041 gacgataaag gaagaaagca cccctaagat gactgtgctt gttctgatca gcgcgaacat 866101 taaaaagtcg tcaccggcag attctaatat cgcaatgact gttacaagag caattgaaat 866161 tgtatgttca attttaagtt tcagcatgat tgtaatgaca ataactgctg ttaacccgat 866221 cataatcggg ctgggtccga aaataaggcc gaacactgtg gcaatcacag ctccgatgat 866281 atttgcttga acctggtcaa taataatgag aaaagagcgg taaatcgacg gctggatcgc 866341 aaatatcgct gcaattccag cgaaaatcgg cgcgggaagc ccgatccacg aagccaaata 866401 aagggcaagt gtaatcgcaa tcccggtttt gaaaatgcgg gcaccaagtt tcattggttt 866461 gtgcgtgcat tcctttctat agtaaattgt gtgacatagc aaatgggcta atccttaaaa 866521 ttcccggtta gtttatttgc taaacaatta agtaatatac agggatcgat acaaatattc 866581 aagctatttt tctagaaaaa gaccaaaatc ttacacgctg tttgattcca taaaaaaaca 866641 ggagctcaaa gctcctgttc aaggtatttg attctagttt tttagatgtt taaatgcatc 866701 ctcgaccgct gtaagcgtgt ctttaatatc ctgctctgta tgtgctgtgg taataaacca 866761 agcttcatac ttagaaggtg ctaaattaat tccgcgttcc agcatcagct tgaaaaacgt 866821 agagaatgtt tctccgtcac tccgttcagc ctgctcgtaa ttttccactt tctcatcaga 866881 gaagtatacc gtgagcgcac cttttaaccg gttgaccgta atggtgatgc cgtgtgtttc 866941 tgcgtgcttc aaaatgcctt cctcaagcat agcgccaagg tgatcaagct tttcatacac 867001 gcctttttct ttgagcactt ccagacaagc gatgcctgat aggatggaag cggggttccc 867061 tgccattgtt cctgcctgat aagcaggccc tagcggagct acctgctcca tgatttcttg 867121 tttgccgcca taggccccaa tcggaagtcc gccgccgata attttcccga gtgctgttaa 867181 atctggtttc acctgtaaga gatcctgcgc gccgccatac ataaagcgga aagccgtaat 867241 gacttcatcg taaataacga gagcccctgc attatgtgtt aattcattta cttgttctaa 867301 gaagccctct ttcggctcca cgataccgaa gttgccgaca atcggttcaa cgagaaccgc 867361 cgcgatttca ctgccccatt tttcaagagc tgctttatag ctatcgatat cattaaatgg 867421 tactgtgatc acttcgtttg caatgctttt cggtacaccg gctgagtctg gtgtgccgag 867481 agtagacggg ccggagcctg cggcgacaag cacaaggtcc gaatgcccgt gatagcagcc 867541 cgcaaattta atgatttttg tccggcctgt atatgcgcga gccacgcgga tggtcgtcat 867601 aacggcttct gtacccgaat tgacgaatct tactttgtcc atagcgggaa tggcttcttt 867661 gagcattttt gcaaatgtaa cctcgtgttt cgttggtgtt ccatacaata caccgttctc 867721 tgctgctttt ttaatcgctt ctgtaatatg cggatgggca tgtcctgtaa taatcggacc 867781 gtacgccgct aaataatcga tgtatttgtt gccgtccaca tcccaaaaat aagcgccgct 867841 tgctttctcc attgcaacag gagaaccgcc gccgactgct ttatatgatc tagacgggct 867901 gtttacaccg ccgacaatgt gctgtaatgc ctcattgtga agttcaattg attttgtatg 867961 caagaataaa aacctcctat atctccatgc gtcctttcta ttgtagcatg cttccgaaca 868021 agaacaatgg cttcgggctt cagattcagc tgagatggtt gtaatctgga caagaattgg 868081 atacgcttaa taaaaaaaca tccggaggta acgtaatgac tatagaaatc ggacaaaaag 868141 cgcctgatct tgagttaaaa ggtgatcatg gggaaacagt aaaattatcg gattataaag 868201 gaaagtacat cgtgctttat ttttatccaa aggacatgac accgggatgt acaactgaag 868261 catgcgattt tcgggacagt cacgaaagct tcgccgaact ggatgccgtc attatcggcg 868321 tcagcccgga cagccaggaa aaacacggaa aatttaaaga gaagcataac cttccatttc 868381 tgcttcttgt tgatgacgag cataagctgg cggaagcatt tgatgtgtgg aagctgaaga 868441 aaaacttcgg aaaagagtat atgggaatcg agcgttccac ttttttaatt gataaagaag 868501 gccggctcat taaagaatgg agaaaagtaa aagtaaagga ccatgtagcc gaagcgcttc 868561 aaaccctcaa agatatgtct gaaaagtaaa tctctatgag cctatgctta cttttaccct 868621 gatatcaatt gacaaattat cgtagaaaga gttacactaa ttataaacat tacaatgtaa 868681 gaattttttt tagaagagag gtgcatgacg gatggctgca catgaactaa aagaagcctt 868741 agaaacgttg aaggaaaccg gagttcgcat tactcctcaa cgtcatgcga ttctggaata 868801 tctcgttaac tctatggctc atccaacagc ggacgatata tataaagctc tggaagggaa 868861 atttcctaac atgagcgtag cgacggtata taacaatttg cgtgtgttcc gggaatcagg 868921 tttggtaaaa gagctcacat acggtgatgc ttccagcaga ttcgattttg tcacatccga 868981 tcactatcac gcgatttgcg aaaactgcgg taaaattgtg gacttccact acccgggcct 869041 tgatgaagtg gagcagctcg ctgcccacgt cacgggcttc aaggtaagcc accaccgttt 869101 agaaatttac ggcgtctgcc aagagtgttc gaaaaaagaa aatcattaaa aataagctga 869161 ccgcacgaaa cggtcagctt attttatttc gacattttct ttttattata agactcatca 869221 aattcttttc cttctaatcc cttatctaaa gtcagcggct ctcggcaatg catgcacata 869281 tcgactactc ctaaaacctt tgtctcttta tcacagcctg gacaaatgac gcgaaccgct 869341 ttagtcgaaa gcattccgat ccaaaagtaa actaccgtgc tgagaccgat ggataaaagc 869401 ccaagtatca taaacaaact agaaagcaaa actgactctt tgaaaaagat cccgatgtac 869461 ataatgataa acccaacgaa aaccaaactt aacgcaaatg ttctgatttt attaattttg 869521 ctggagtatt tcgccatgtc catccccctc tgttttaact atagcacaaa cccgatggga 869581 ttttcttcat gttttcggtt gaactggaat ttacatatgg agagttactg tgaaattgtt 869641 tataatagtt caatgtgttt agaaaaaagg aatttcgttt taaccataga attgaatcaa 869701 atagagaata aaaaaatttg aacaattgca ttggaggaat agtgatggaa aatcttctcc 869761 gtccaattta ccaagaaaga gcaagtcacc ccaatacatt ggctgtcatt atgattgaga 869821 gaagaaacaa aacatcttcc ttaacagata actttgatgc agctttgctg gtgattgtaa 869881 aggatgctga tgagccagtt tttataaagc attatgaatt tgatcatcaa acagcttctt 869941 tgcatgtggt aacagattct cagattcaag aatggatttt gcttggaaca aatagaagaa 870001 tcatagattg gattgtaaat ggcagagtct tgtttgaccg taatgaatac gtagttgaac 870061 tgattgacag gctgaataca tttccgtttg ccgaacgtaa actgaagatc ggactcgaat 870121 acggcaaatt aatcagaagg tatgttgaag ggaaagcttt ttttgaagcc aatcaatttt 870181 tagatgccta caatgccgtt gttcatgcgc tgcatcattt agcacgtatt gaagtaatcg 870241 acagaggatt ccatcccgaa accacggtgt ggagccaagt gcgccagatg gagccccaag 870301 tgtacaaatt atattccgag ctgattgaaa gtcatgagag cctggaaaaa agacttgaat 870361 tattattctt agcaaatgat tttctcatcc attccaaagc cgagatcggt tcggcgcatc 870421 ttttcgaagt aatgaaagaa aaagacattt ggcaattcgg tgagcttctt caacatcatg 870481 acctaaagca ctttacccaa gatcttggcg ttatgcttga ttacttgacg gaaaagggac 870541 ttatcaacgt ctgccagata gaaacgaaag gacaggctgt ctatcaccga ggatattctt 870601 ttaaaaaagg tgttgactct gattcttgac cgtgttatat tattaaacgt cgctgatgcg 870661 cttctgagaa aacaagctca cagcggcggg aaaataaatc aaaaaaacat ttgacaaaag 870721 aaagtcaaaa tgttatatta ataaagtcgc ttcaacaaga agtgaaaatg atctttgaaa 870781 actaaacaag acaaaacgta cctgttaatt cagtttttaa aaaatcgcac agcgatgtgc 870841 gtagtcagtc aaactagggc ctgcacgacg caggtcacac aggtgtcgcc gcaggatgcg 870901 gtgaacttaa cctgtgatcc atttatcgga gagtttgatc ctggctcagg acgaacgctg 870961 gcggcgtgcc taatacatgc aagtcgagcg gacagatggg agcttgctcc ctgatgttag 871021 cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata actccgggaa 871081 accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa aggtggcttc 871141 ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta acggctcacc 871201 aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac tgagacacgg 871261 cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa agtctgacgg 871321 agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt tagggaagaa 871381 caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc cacggctaac 871441 tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat tattgggcgt 871501 aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca accggggagg 871561 gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca cgtgtagcgg 871621 tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg gtctgtaact 871681 gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt agtccacgcc 871741 gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca gctaacgcat 871801 taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat tgacgggggc 871861 ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc ttaccaggtc 871921 ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga gtgacaggtg 871981 gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca 872041 acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc cggtgacaaa 872101 ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg gctacacacg 872161 tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat cccacaaatc 872221 tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat cgctagtaat 872281 cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg cccgtcacac 872341 cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca gccgccgaag 872401 gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag gtgcggctgg 872461 atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta taaacagaac 872521 gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct ttgaaaacta 872581 gataacagta gacatcacat tcaattagta atacaagata tcacatagtg attcttttta 872641 acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg atgaaggacg 872701 ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga gatttccgaa 872761 tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata ggatatgaga 872821 aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc aaatgcgatt 872881 ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc ctcttggggt 872941 tgtaggacac tctgtacgga gttacaaaag aacgaggtag atgaagaggt ctggaaaggc 873001 ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag tggatcctga 873061 gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc aaggctaaat 873121 actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag caccccggaa 873181 ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc gttaacgggt 873241 gatggcgtgc cttttgtaga atgaaccggc gagttacgat cccgtgcaag gttaagcaga 873301 agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt ggtcgtagac 873361 ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg aatggaggcc 873421 cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga aatgccaatc 873481 gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca aggtaagagt 873541 cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa ttcagtcaaa 873601 ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga tccgtagtcg 873661 aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag tggaaaagga 873721 tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt taaagagtgc 873781 gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta aacgtatcac 873841 cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc tgtgaagcca 873901 gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta gcgaaagagg 873961 ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt ccgctcaggg 874021 ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg ttgatattcc 874081 tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg taagcgcggt 874141 attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt tcccataagg 874201 ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca ctgccaagaa 874261 aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag gcgaggagag 874321 aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac cccgtaactt 874381 cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga ataggcccag 874441 gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta taggggctga 874501 cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg tgcgaattga 874561 agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat tccttgtcgg 874621 gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac gagagactcg 874681 gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa agaccccgtg 874741 gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata ggtaggagcc 874801 ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc tggctgtatt 874861 gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg cagtttgact 874921 ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag aatggttgga 874981 aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac aagtcgagca 875041 gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat cgctcaacgg 875101 ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat cgacggggag 875161 gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc caagggttgg 875221 gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag acagttcggt 875281 ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg agaggaccgg 875341 gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg tagctatgtg 875401 cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat gagatttccc 875461 attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg aggtggaagt 875521 gtggcgacac atggagctga cagatactaa tcgatcgagg gcttaaccat atttttgaat 875581 gatgtcacac ctgttatcta gttttgagag aataagtttt tcaaaaaaac acttgatttt 875641 ctcaagaata catagtataa tgttaaatgt cactgaaatt gtctggtgat gatggcgaag 875701 aggtcacacc cgttcccatg ccgaacacgg aagttaagct cttcagcgcc gatggtagtc 875761 gggggtttcc ccctgtgaga gtaggacatc gccaggcaga cttcattccg cagtagctca 875821 gtggtagagc tatcggctgt taaccgatcg gtcgtaggtt cgaatcctac ctgcggagcc 875881 attattggag agctgtccga gtggtcgaag gagcacgatt ggaaatcgtg taggcggtca 875941 actccgtctc aagggttcga atcccttgct ctccgccact gatacttata cataattaca 876001 attgaaagtc tgggcccgtt ggtcaagcgg ttaagacacc gccctttcac ggcggtaaca 876061 cgggttcgaa tcccgtacgg gtcattatat gatggaggat tagctcagct gggagagcat 876121 ctgccttaca agcagagggt cggcggttcg agcccgtcat cctccaccat tatatcatcg 876181 cggggtggag cagttcggta gctcgtcggg ctcataaccc gaaggtcgca ggttcaaatc 876241 ctgcccccgc aaccaaattt taaaatggtc cggtagttca gttggttaga atgcctgcct 876301 gtcacgcagg aggtcgcggg ttcgagtccc gtccggaccg ccatttgaat acttaggctc 876361 ggtagctcag ttggtagagc aacggactga aaatccgtgt gtcggcggtt cgattccgtc 876421 ccgagccacc acctatgccg gtgtagctca attggtagag caactgactt gtaatcagta 876481 ggttgggggt tcaagtcctc ttgccggcac tgttttttca aaatttaatg tggaggggta 876541 gcgaagtggc taaacgcggc ggactgtaaa tccgctccct cagggttcgg cagttcgaat 876601 ctgcccccct ccaccattta taggggcata gtttaacggt agaacagagg tctccaaaac 876661 ctccggtgtg ggttcgattc ctactgcccc tgccaaattt atgacatctt gagattatgg 876721 cggttgtggc gaagtggtta acgcaccaga ttgtggctct ggcactcgtg ggttcgattc 876781 ccatcaatcg ccccatatta tcattgggct atagccaagc ggtaaggcaa cggactttga 876841 ctccgtcatg cgttggttcg aatccagcta gcccagtctc actttttata tcaactgcat 876901 ataatgtatt aagtccatta aaaatgcgga agtagttcag tggtagaaca ccaccttgcc 876961 aaggtggggg tcgcgggttc gaatcccgtc ttccgctcca attacggcgg catagccaag 877021 tggtaaggca gaggtctgca aaacctttat ccccggttcg aatccgggtg tcgccttctt 877081 attgccgggg tggtggaatt ggcagacaca caggacttaa aatcctgcgg taggtgacta 877141 ccgtgccggt tcaagtccgg ccctcggcac caattttact tacatggtaa gttgaattgg 877201 tgtttgtgtt ttatcattat aactaatcat attaatgatc tacataagta gatcattttt 877261 ttaatgcttt gatttatcat aacaagttaa gttccgaggc ctattataaa gcggctgtat 877321 agctagtctt tcaacacttt tattttatat ttccataaaa acttttttga aatacgttga 877381 cactttatga gatccatgat atatttatat tcgtcggtta gatacgacgt aaaacttgcc 877441 ggtgtggcgg aattggcaga cgcgcacgac tcaaaatcgt gttccttctg gagtgtcggt 877501 tcgaccccga ccaccggtat actgaaaaac ccgtttctta acagaaacgg gtttttattt 877561 tttattaaag aaaaggagcc tcggctcctt tttatactta ctcagcgtat tggtctagga 877621 tctcttctag cacctcttct agctcttctg tatcttcaag ctctgattgg ctgaaacgga 877681 cgcgtacaag ctgttctccg tcattataca tctcttccaa ccaccctcgg agtcctcttg 877741 ctctgcggtc gacttcgaaa atgatttcca aaccgtcttc gtctaaaagg aaaatgagct 877801 ctaattcatc aagcatctga cgataatatc cggaagtcgg aacgaattcg aattcttgaa 877861 cgaacggaag acgacgctgg aagtagggcg cttgttcgca gtctgcttcg ttaagacgga 877921 agcccaggtt ttcgattgct tcaagcacat tttcaatcca agggtgcgct tcaacgaaaa 877981 tgcggtcatg atcggattta tcgataccgc cttgaatgtc aaggtctgtc accacggcaa 878041 cctctacttt ccctacagtg atcggcgtat ctagaggcag agtgaatgtg aacggaaatt 878101 gatgctcttc accaggctgt atggtaaatg aaccagtgac ccggaaagaa tgaattgtag 878161 cgtatttccg gtgctcttca tcgtctttta caatgacata ccgtgtgcta agctgtaaat 878221 cgatataacg gatgtcctga gcgatttttc cgcctttgac atgtaccgtt ccctgtactt 878281 cttctcctgg aaaatatgcg tctttttcta aaattgtatc tacttttgca gctccaattc 878341 cggcacttgc cgcaagcttc ttaaaaaatg acatgttaga tcttcccctt tttctttttt 878401 ctcaacagat atacgtaaga aggaggaaaa aagattcgtt tgattcatac ttttttccta 878461 ttattcgtct cggcctaggg acagactaag aataatattg aaaataaagg agtcgatgga 878521 agtgaataaa gaaagtttgg ttgcagatga attacacaga atgtttttgg ctggtgagct 878581 gcaaatcaca gtagaggagg atataaacaa tatttccgaa aggctgagaa acggcgatct 878641 cagtttagac cgattaagcg gtgaagacgt gtttataaaa gaaacggtaa atgaggcttt 878701 aagaagagtg gagcaataaa aaagagacgg catctcatct ttgagatccc gtctcttttt 878761 gtggtctttg ctgtaagata aaagcgaatc gatttggaat tgctcacccg agccacccct 878821 tttctaacag aagatctgac agttcatcat ggagataaac agctgtatct aattgatcat 878881 gcaatgctct tctgatgtgg ggattttcgg ttgctgttgt tgcgacagtg tatttgttaa 878941 tgctggtttt tattgttgtt aacaaatcaa gaatatcttt gggacaaaga ctttgttcaa 879001 tgggaaacca cctcctttgt ttttttagca gctcctgata agaaagtatt tgactttgtt 879061 tcttgcttct atacaaaatg ctataataag caacaaattt tgttgggggg tgtgatgatg 879121 aagcagatta ttgcgatggg gggcgggggt ttttcgatgg agccggataa tttgtccctc 879181 gatcaatata tcctcaatca atcaaaacga gagcagcctc gtatttgttt tttgccgacg 879241 gcgagcggag attcccaaaa ctatattcag cggttttatc atgcatttca aacattggat 879301 tgcgtgccgt ctcatttatc tttgtttaag ccaccatcat cagatttagt ttcttttgtt 879361 atggaaatgg acgtgattta tgttggcggg ggaaatacgc ggaatttact tgtgttatgg 879421 aaagagtggg ggctggacca tattctcagg gaagcatgga agaacggtgt ggttgtagct 879481 ggaataagtg ccggtgcgat ctgctggttt gaagaagggg tgacagattc agccggaccg 879541 ctgacaagtt tgaaaagttt aggttttttg caagggagct tttgtcccca ttatgacggg 879601 gaaaaggatc ggagaccggc ataccaccag ctgatatcta acaagttctt atgcagtggc 879661 tatgcagcgg atgatggggc tgctctccat ttcataaatg atcagctgtt tcagactgtg 879721 agttcaaggt cgggtgcaaa ggcatatcgg gtgatgatgg ctgaacatga aatagctgaa 879781 atcccgttgc cggtcaaata tttagggtga aattggctga atattatcta tattcctctt 879841 tttttcagat tgattttatg ataagatgag tgcgaaatca atagttactg ggggtgcccg 879901 ctttcgggct gagagagaag gcaagcttct taaccctttg gacctgatct ggttcgtacc 879961 agcgtgggga agtagaggaa ttgtttttgt tattgtcttg ctgggcaata atatgtttct 880021 ttctgactgt aaccgggttc atttatatga atccggtttt ttgtgctggt tatgggcttg 880081 attttgtcct ttcaaacgta gaaaggggaa ggaaaagtaa tgcaaaacaa ttcagtgcag 880141 caagccaaca tttccattat gtcaagtttt tcaggcagca agaaggtata cgtggagggt 880201 tcttcttcgg acatccaagt gccgatgagg gagattgcat tgagtccgac gacgggatcg 880261 ttcggcgaag aggaaaacgc gcctgtgcgt gtctatgata caagcggacc gtatacggac 880321 cctgaagtaa ccattaatat tcaagaagga ttaaagccgc tccgccaaaa atggatcaca 880381 gagcgcggtg acgtggaaga gtatgaaggt cgggctataa aaccagaaga taacggttat 880441 aaaaaagcaa aaccaaacgt aagctatcca ggattaaagc ggaaaccgct gagggcgaag 880501 gcaggtcaaa atgtcacaca aatgcactat gcaaaaaagg ggatcattac acctgagatg 880561 gaatttatcg ccattcgtga gcatgtgtct cctgaattcg tcagagacga ggtagccagc 880621 ggccgggcga ttattccttc aaacattaat caccctgaaa gtgagccaat gattatcggc 880681 cggaattttc atgtgaagat taatgcaaat atcgggaatt cagcggttac gtcatccatt 880741 gaagaagaag tggaaaaaat gacgtgggcc atccgctggg gagcggatac gatgatggat 880801 ctctctaccg gaaaagatat tcatacgacg cgtgaatgga ttatccgcaa ttgccccgtg 880861 cctgtgggaa ctgttccgat ttatcaggcg cttgaaaaag taaacggcgt agctgaggat 880921 ttaacgtggg agatttatcg tgatacgcta atcgagcagg cagagcaggg agtggattat 880981 tttacgattc acgcgggtgt tttgcttagg tatgtaccgc tgactgccaa acggacaact 881041 ggtatcgtgt cacgcggggg agcgattatg gcgcagtggt gtctggctca tcatcaagaa 881101 agctttttat acacacattt tgaagaaata tgtgagatta tgaaaatgta tgatattgct 881161 ttctctcttg gggatggttt gcgtcccgga tcaattgctg atgccaatga cgaagcgcag 881221 tttgctgaat tagagacgct tggagagctg acgcaaattg cctggaagca tgatgttcag 881281 gtgatgattg agggtcctgg acatgttccg atgcataaaa tcaaagagaa cgtcgataaa 881341 caaatggaca tttgtaaaga agcgcctttt tacacattgg ggccgttgac aacggatatt 881401 gctccgggat atgaccatat tacttcagcg atcggagcgg cgatgatcgg ttggtacggg 881461 acagcaatgc tttgttatgt aacgccgaag gagcatttgg ggctgccaaa ccgtgatgat 881521 gttcgtgaag gagtcattac atataagatc gctgcgcacg ctgcggacct tgcaaaaggg 881581 catcccggag cgcaaatccg ggatgatgcg ttatcgaaag cccgttttga attccgctgg 881641 cgggatcagt ttaatttatc tcttgatccg gagagagccc ttgaatacca tgatgaaacc 881701 ctgcctgctg aaggagcaaa aaccgctcac ttttgttcca tgtgcggtcc gaaattttgc 881761 agcatgagaa tttcacagga tattcgggat tatgcgaaga aaaacgatct cagtgaagca 881821 gaagccataa ataaaggatt aaaagaaaaa gcaaaagagt ttgtcgatac gggaagcaat 881881 ttatatcaat aaaaaaaatg aagatggaga atgctccatc ttcatttttt tagaaaaaca 881941 gagagcgtcg aagcggagga atactctgtt caaagcggaa aacattttct ggatcatatg 882001 tcgttttgac acggcggagt cgttcaacgt tttcgccgta atatgttctt ggccagtttc 882061 tgatttcgat atctggccaa tttacgtagt ctcccatcgt ttctttcgaa agggacgttc 882121 tcagcccctc aatccagcgg acattttgtc ttttttctcc aggggatgtc cagtttgtta 882181 agtattcctg ggcgatgatt gcgtcacgat aataaaatgc cgtttggtcg ggagcgaccc 882241 gtccggctgc cccgccgagt gcttgctgcc agacactggc gttttgattc ggagcgtgct 882301 ctaaaaagtg ttttattgtt gagatcgcac gttctgataa tggcttttca atgaaagagc 882361 cggagcgttt cattttttga ggctgattgc ctcccgggct gttaaaaaag gttaccgctt 882421 caatgaatgg cgttgttttt accattccgc ttgtcggact tcctgctttc aataaaggct 882481 ttaacagttt ttttaactct gtttttggcc cgacaaattg gccgagggct tctatgcggt 882541 ttacttcttt aggccaaaac tctattgatg atgtaagccg gtcatctgta tacggggccc 882601 agttctgcca cgtgttatat acttcctcaa aatcatccca tccccatgta atagaaaaaa 882661 tcgacacttg agagatgggc actgctttaa atgtcatgga ggtgactatg ccgaaattgc 882721 ctcctccgcc tccctgagac gcccaaaata agtctggatg atttgaacag ctgactgtaa 882781 tcagatcagc gccctctttt tcgtctgcta cgatcatctc aagctgcacg aggctgtcgc 882841 aagtaagacc ggcagccctt gttaaaagtc caattccccc tccgagagtt aaacctgtga 882901 gccctacatt agcaatggtg cctgcgggaa gcgtcaggcc gtattgccag agtgtccgat 882961 agacttctcc caattcagcc cccgcttcaa tataggccag ctttttatcc tgattcacag 883021 ttattttttt catctcgctt aaatcaataa caagaccgtt atttaaaagg gaaaagttct 883081 catagctgtg tctgccgcct ctaatacgga aaggcacacg gttttcacgc gcccatttca 883141 gcgcattgag tgcatcctgt ttgttttggc aaaacacaat gatgtcagga tacctttcta 883201 agcttaggtt aatattggtt cttgcttcgt tatagtccgg atcatcccgt gtcacgatac 883261 gtccggtcaa ttttgtcttt tccacactcc cacatctctt tctctcgtat tctagtttct 883321 ctagcttatg cgtcagggga aaagagtgta taaggaaaaa gcggggatgc aatctgatac 883381 agtgtcaaca ccctcaaaaa atagttgaca ggtcggtatt gtatgaatta acatggtcag 883441 tacaaatttt tcaaatttat cgcgctgatc ggaacaccga aggctcttat cgtttagata 883501 agggcctttt ttgtatgaaa aaggggggat tattgatggg agtcaaaaaa gaaaagggga 883561 gaaaacgatt caggaagcga aaaacctacg ggaatcagat tttgccgctt gagctgctga 883621 ttgaaaaaaa caaacgagag attataaaca gcgcggaact catggaagaa atttatatga 883681 agattgatga gaagcatacg caatgtgtaa ctaaatataa aaaaacccgc tgactacaac 883741 gggtttttgc atttctccat taagaatctt ttttaatcgg caatccaagg ccttctgcca 883801 cgcgttttcc gtattcagga tccgctttgt agaagtgctc gatttggcgc agcttgattt 883861 cttctttttc taccggcttc atggcattaa cgatattttc aacaaggcgg gtacgttcat 883921 cttcactcat taaacgatac agatcgccgg cttgagtgta gtgatcgtag tgatcgtagc 883981 ttacgctgtc agcgatacct tgtaccggat atgctgcttg cttatcctca ggtgactctt 884041 ttggaccgcc gaagctgtta ggctcgtaat acacagatcc gccgccgtta tcatcaaaac 884101 gcatttgccc atcacgctga taattgttta ctttgttgcg tgcgcggttg attggcagcg 884161 cttgatggtt tgcaccgaca cggtagcggt gtgcatcatg ataagcaaaa agtcgacctt 884221 gaagcatttt atccggtgaa acatcaatac caggcacgag ggttccaggt gaaaatgtcg 884281 cttgttctac ctctgcaaag tagttttccg gatttctgtc tagaaccatg cgtccgacct 884341 cgattaacgg gtagtctttt tgagaccaaa cttttgtgac atcaaacgga tcgaaacggt 884401 acgtatttgc atcttctaaa ggcatgattt gcacatatag tttccatgca ggataatcac 884461 cgttttcgat tgcgttgaaa aggtcttctg tatggtaatc agggttttca ccggcaattt 884521 ttgctgccgt attgacatca aggtttttca cgccttgttc tgttttaaag tgatatttaa 884581 tccatacgcc ttcgccttcg gcatttgtcc atttgaatgt atggcttccg aagccgtgca 884641 tgtggcgaag tgtcgcagga attccgcggt cagacatcag gattgtcact tggtgcagtg 884701 actctggtga aagtgaccag aaatcccata cagccgtagg gtttttcagg tgtgtttttg 884761 gatctctttt ttgtgtatgg atgaaatcag ggaacttaat cgcatcgcgg ataaagaata 884821 caggcgtatt gttgccgacg atgtcgtagt ttccttcttc agtataaaat ttaacagcaa 884881 atccgcgcgg gtcgcgaact gtgtcagcag agccaagttc accggcaact gttgagaaac 884941 ggatgaacaa cggtgtgcgt ttgccgactt cagaaaggaa agcggctttc gtgtattttg 885001 ttacgtcgtt tgtcacttca aaatatccgt gtgcgcctgc tcctttggcg tgaacaacac 885061 gttcaggaac acgttctcgg ttgaaatggg ccaatttttc gagtaaatgt acatcttgaa 885121 ttaaagttgg tccgcgagaa ccggcagtca ttgagttttg attatctcca accggagcgc 885181 cccagctagt tgtcagttta tttgaactca tgttatcacc tcttggaatt tataagaaca 885241 taatatcatc tctaagtaaa aagtcaatat tattttataa ttattataaa atagttatct 885301 ctattaatcg atatatagta tcgaaattgt tgaaaaacct tgttgtaaca gctttttatg 885361 acacttaata atttttggag aaataatttt tccttctcta tttgcgaaac aagcagagta 885421 agtgataaac aaggatatca aaaatcgtat ttaaaaaaga gttgacatat cggaataatt 885481 tgaattaaca tgttattcaa acaaaaaaac aattgggcag ctgatcggac cgccgaaggc 885541 tctcatctct acaagaacag agatgggggc ctttttgttt tttttgaagg cggggttggc 885601 agaaagagag ggataaaagt ggctgtgacc atcagcatca aagaaaaggc atttgttcaa 885661 gaaggccgca aaaacacggt cttagaaaac atagaattat caatcgcacc aggcgaattt 885721 ctaacgctta tcggaccgag cgggtgcgga aaaagcaccc tgttaaagat tattgcaggg 885781 cttgattctg aatatgacgg gagtgtggaa attaacggcc gcagcgtaac agctccgggt 885841 attcagcaag gatttatttt tcaggaacac cgcctctttc cttggctgac tgttgagcag 885901 aatattgcag ccgacttgaa tttgaaggac ccaaaagtca aacaaaaggt ggatgaactg 885961 atcgagattg tcagattgaa aggatcggaa aaagcatatc cgcgcgagct gtcaggcggc 886021 atgtcacaaa gagtagccat cgcccgggcc ctgctgcggg agcctgaggt gctgctttta 886081 gatgaaccgt ttggtgcact cgacgctttt acaagaaaac acctgcagga cgtgctgctg 886141 gatatatgga ggaagaaaaa aacaacgatg attctcgtga ctcatgatat agatgaatct 886201 gtttatttag gaaatgagct tgcgatcctt aaggccaaac cggggaaaat ccataagctg 886261 atgcccattc acctggcgta tccgcgaaac cggacgactc cggatttcca agcgatcaga 886321 cagagagtgc tgtcggaatt cgagaaaaca gaagatttgg agtacgcaga aggatcaggg 886381 atatagaaag ggcggaagcg gaaatgaaaa aaggactcat tgtattggtt gccgttattt 886441 ttctgctcgc aggctgtgga gcaaatggag ccagcggtga ccacaaacaa ttgaaggaaa 886501 ttcgtattgg tattcagcaa agcttaagcc cccttttgat tgcaaaagaa aaaggctggt 886561 tcgaagatgc atttgaaaaa gaaggcatca aagtgaaatg ggtggagttt caaagcggtc 886621 cgccccaatt tgaaggcctt gcggcagaca aacttgattt ttctcaagtc ggtaattcgc 886681 ctgtgatcgc tggacaggcg gcaggcattg actttaaaga aatcggtttg tctcaggacg 886741 gcttgaaagc aaacggcatc cttgtcaatc aaaacagcgg cattcaagac gttaagggct 886801 taaaggggaa gaaaattgca gtcgccaaag gcagcagcgg gtttgatttt ttgtataaag 886861 cgcttgatca agtggggttg tcagctaacg atgtgacaat tattcagctt cagcctgatg 886921 aagcagcttc cgcatttgaa aacggatctg ttgatgcctg gtccatttgg gagccgtact 886981 tgtccttaga aacaatgaaa cacggagcaa aaatccttgt gaacggagaa agcacagatt 887041 tatattcacc gggttttact ttagtaagaa caaagttttc agaagagcat ccagacgaag 887101 tggtccgttt tctgaaggtg tttaataaag ccgttgtatg gcaaaaggaa catctggatg 887161 aagcagcgga cttatattct gacattaaag atctcgataa aaaggtcgtc gaaaatgtgc 887221 tgaaaaatac tgagccactt aatgagatca tcagtgacga cattgtgaaa gcacagcagg 887281 aaacagcaga ttttcaattt cgaacaaagg cgatagataa gaagattgat gtgaaggatg 887341 ttgtcgataa cacttttatc aaaaaagcat tagaggagca ttcctcagga ggtgatcaat 887401 gatgaaagca gaggctgcgg gctcgctgcc caaaacgaat gcggaagcgg tgcgaaaaaa 887461 gcccggaagg aagagatacg gctggatgaa ggggctttta ctgcccgctg tcatcattgc 887521 catctggcag gtcatcggcg ggctgggggt tgtgtccgct acagtgctgc ctacacctgt 887581 tacgattgtt ctgaccttta aggagcttat tttgtccggc gaactgttcg gccatctgca 887641 aatcagcatt tatcgggcgg cacttggttt tttgcttggc gcggggcttg gattgatgat 887701 cgggattttg gccggatttt ccaaacggac ggagctgtat cttgatccgt cgttgcaaat 887761 gcttagaacc gtacctcatc tggccgtcac gccgctgttt attttatggt tcggatttga 887821 cgaagtatct aaaattttgc tgattgcgct cggtgccttc tttcctgtct atatcaatac 887881 gtttaacggc atccgcgggg ttgacgcgaa gctgtttgaa gtcgcccggg tgcttgaatt 887941 taaatggcat cagcagatat ccaaagtgat attgccggca gccctgccca atatattgct 888001 aggcattcgc ttatcgctcg gcattgcatg gctcgggctc gttgtggcag agctgatggg 888061 ctcaagctcg ggagtcggct atatgatcat ggatgcgaga cagttttcac aaacgaataa 888121 agtctttgca gggattatca tttttgcagt ggttggaaag ctgacggatt ccttcgtcag 888181 gctgcttgaa cgaaagctgt taaagtggag aaacagctac gaaggataaa agatataaag 888241 gggagatgaa tatggaaatt ctttggttta taccgactca tggagacgcg agatatttag 888301 gatctgaaag tgatggacgg actgcggatc atctttactt taaacaagtc gcgcaggcgg 888361 cagacaggct gggatataca ggagttcttc tgccaacggg aagatcgtgc gaggacccgt 888421 ggcttacagc gtcggcactg gcaggagaaa caaaggactt aaagttttta gtcgcggtaa 888481 gacctggttt aatgcagcct tctctggcag ccagaatgac atccacccta gaccgcattt 888541 cagacggccg gctgctgatc aacgttgtgg cagggggcga tccgtatgag ctggcaggcg 888601 atggcctgtt tatcagccat gatgagcgct acgaggcaac agacgaattt ttaaccgttt 888661 ggcggagact tttgcaggga gaaacggttt cctatgaagg aaagcatata aaagtggaaa 888721 acagcaatct gcttttcccg ccgcagcaag agccgcatcc gcccatctat ttcggtggtt 888781 cgtcacaggc tggaattgaa gctgccgcaa agcatacaga cgtgtacttg acatggggtg 888841 agccgcctga acaagtaaaa gaaaagatag aaagagtcaa aaagcaagcg gcaaaagaag 888901 ggagatccgt tcgatttggc attaggctgc atgtcattgc ccgtgaaact gaacaagagg 888961 catgggaagc ggcagagcgc ttgatcagcc acttggatga tgacaccatt gccaaagcgc 889021 aggcagcttt gagccgttac gactcttcag gccagcagcg gatggccgtc cttcatcaag 889081 gcgatcggac gaagcttgaa atcagcccga atctgtgggc ggggatcggc ctggtcagag 889141 gaggggcagg aacagctctt gtcggtgatc cgcagacgat tgccgaccgg atagcggagt 889201 accaggcact cggcatagaa tcgtttatat tctccggcta tccgcattta gaagaagcgt 889261 attattttgc agagcttgta tttccgcttt tgccgtttga aaatgatcgg acgagaaagc 889321 ttcagaacaa aaggggagaa gcggtaggaa acacttattt tgtcaaagag aaaaatgcat 889381 gagtttaact aaaatacagc cccccgaaca tggtatgata ttcaaaaaaa gggggctttt 889441 tttctgaaaa cattgagaag cgcggcagtc atttgcctca tagctatgct gtcagcatgc 889501 ggacattcaa aacagatgga aatcaaagcg gcggacatat cagatcttga aaaaaacaga 889561 atggatgtcg cagcttcaca ggcattcact gccgaagccg tcaatatcgg tgaaggtatt 889621 tcttcagctg acatgtacat cgaacattat caaaagggaa agcttgttga gaggtttgga 889681 ccggttcgtg cagattattc agaggaaaaa actgatacca tacaatttgt ttattttgag 889741 aatgaagagg gggaaggaaa gaataaacat accaccattc attttggcat tgtggataaa 889801 cagggaacta tagcggctga ttcatcggtg aaacgcgacg atagcacaac acaggaaatg 889861 actcagaata tttcatcgcc ggaaccgatt actttcgaga agcctgcttt gatcggcagc 889921 agtattagag ggactgacga gacaatgcac acctctgaac ataaaaaaga gctcattaag 889981 catcaagatg cgttactgta ttatgtggaa ttgcatcatt agaatgggcg gcttcaggcc 890041 gtctgtttta caaagcggta tgcttgcttt tttgaatggt gaatgataca ttttaaatcg 890101 taacaatttc gatttaaagg gaggctatgt gacttggcta aaaaatcaaa agtggcaaaa 890161 gagttaaaac gccaacagct tgttgagcaa tacgctggta ttagacgcga gttgaaggaa 890221 aaaggagatt acgaggcact cagcaagctg ccaagagatt cagcaccggg aaggcttcac 890281 aaccgctgca tggtaacggg gcgcccgaga gcatatatga ggaagtttaa aatgtccaga 890341 atcgctttca gggagctggc ccataaaggc cagattcccg gtgtgaaaaa agcaagctgg 890401 taagaaaaaa ctccggccga ttacagcgcg ccggagtttt tttcgttttt cttgaaagag 890461 atgacgtagg aaaggtgctg gatgatcatg atgataaaca caataataat agggaaaaac 890521 ggaatgcgcg attgaaatag cggataaaaa atgagaagaa ccgctgcggc aggcagcgag 890581 aagtagacag cgatatatga cgcgcgacat gcttttgccg tcatcatctg ctctctttca 890641 tcctgctctt caaactcatc aggcagaagt agctgctttc tggcagggcg gctttttttc 890701 tgtaagtaca aataaaccgc agacgccgca acaaacagaa taaagggagt gaggtttaaa 890761 tcaaatacca tcccgccgct ctttgtgccg aaaaaagatg ctatgccttc tgaggcttca 890821 aagtatgaaa tcagcgccca gcatgcaagg ccaaataaaa caaggtgaaa agctgctttt 890881 gttttcatgc tcatcttagt tttcctcctc taaccaaaag acatcctcca ttttcatgga 890941 gaaggctttg cagattttca gtgctaacag cagtgaggga acataatcgc ctttttcaat 891001 cgctgccaca gtctgtcttg tgacgccgac cgtttctccg agtttttcct gagaatagcc 891061 gaagcgtgcc ctcagctctt ttactttatt tttcatcatg acgtctgtcc ccttcacaat 891121 ctcgattgat tatattgtat agtatactta acattatgta aatggaactt aacaacttta 891181 caaaaagata actttttttc gacaaaattt ttatattccc ttgacgaaaa ataaataaac 891241 atgtaatata aaaaaagtca gagcggtact gttgctgaca atcacaaatg cgggtgtagt 891301 ttagtggtaa aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct 891361 ccatacatac gttattaacg cagtgtttcg tttctcagat aaacgaagta ttgcgttttt 891421 ttatgtgaaa aagaacacgg tattcgtgtt cttttacgta agccaatgta ctgtatgggt 891481 gccgccgtga atttgttcaa acattttcgt taatgatgat aagaggttaa cagcgctgct 891541 tttctcaatc gatggcggga aaaaaatgat ttgcagcata ttcttagtct cgtttgaaac 891601 gggatagtgg ttgacgctgt ttttgaaatc gccaaaaatg ccgttttcat cagagaaaag 891661 cagtatgttt tctttttctc ccaatgagat ccggaccggc tcatgaagct ttccggcatc 891721 ataaatcata ataggcagag aatattttaa tgcgaaaaaa tcgattgtgt catgggccga 891781 gtctttactt tccatgaatt gttccttgga tatcgggacc agcatgtcct ccattggggt 891841 tgtttctccc tcaaatgaag ggttaagctg tttaaagagt ttctgccatt ccttgacgaa 891901 ggattcatcg gatataccgc cgtccgcata gtcgaaaaac aaggattctt gaaacaggcg 891961 gagtctgcct ttcagcattt gcggtgagga gccgacttcg atattctcat aaatgacagc 892021 agctgcatgt aagccggccg cacgttcagt aataacagaa tcaagtttga tattcactag 892081 cattcactcc agttacgtga tatcaaccta ttataaacgc tgtgtcgttt tatcacaaag 892141 aaaggaggct gtgcaaaaca tgaacgttta tcagctcaaa gaagaattaa ttgaatacgc 892201 gaaaagcatt ggcgtagaca agattggttt tacgaccgct gatacttttg acagtttaaa 892261 agaccgtttg attcttcaag aatcactcgg ctatctctcc ggctttgaag agccagatat 892321 cgaaaaaagg gtgacgccga agcttctttt gccgaaagcg aaatcaatag tggcaattgc 892381 tctcgcatat ccttccagaa tgaaggatgc gccgagaagc acgagaactg agcgcagggg 892441 cattttttgc agagcttcct ggggaaaaga ctatcatgat gtgctgaggg aaaagcttga 892501 tctgctggag gattttctaa aaagcaagca tgaggatatc agaacgaagt caatggttga 892561 tacaggtgaa ttgtctgatc gcgccgttgc ggaacgtgcc ggaatcggat tcagtgcgaa 892621 aaactgtatg atcacaacac ccgagtatgg ctcttatgtg tatttggcgg aaatgatcac 892681 aaatatccct tttgagcctg atgtgccgat tgaagatatg tgcgggtcct gcacgaaatg 892741 cttggacgcc tgcccaacgg gagcactggt taatcccggg cagcttaatg cgcagcgctg 892801 catctctttt ctgacccaga caaaaggatt tttgcctgat gaattccgga caaaaatcgg 892861 aaaccgcctg tacgggtgcg atacgtgcca aacggtatgc cctctcaata aagggaagga 892921 ttttcatctt catccggaaa tggagcctga tcctgagatt gccaaaccgt tattgaagcc 892981 gcttttggcc atcagcaatc gggaatttaa ggagaaattc gggcatgtct caggttcttg 893041 gcgcggaaaa aaaccgattc agcgaaacgc cattctcgcg cttgcccatt ttaaggatgc 893101 ttccgcactg cctgaattga cggaactgat gcacaaggat ccgcgtcctg tcatcagggg 893161 gacagccgca tgggcaatcg gaaaaatcgg agaccccgcc tacgcggaag agcttgaaaa 893221 agcgctggaa aaagagaagg atgaagaggc aaagctggaa attgaaaaag gaattgagtt 893281 gctaaaagct tcaggcatga ctaaacaagg cctgtcctga catacgtata gagcagaagg 893341 aaaaaacact tgagatcatc caagtgtttt ttctctataa aaaagtatgg cgggtggggt 893401 gagcttgaag tacattttag aacaattagc ggaggagcgg ctgggctttc tggttaacgg 893461 gcatgctatg agacaggagt ctcaagtcgg agaccttaaa gtcatggagc gtaagaaaaa 893521 gcttctggaa aaacgtaaag ttgacatcat aaaagcgaaa gcaaaggccg tgattaatca 893581 tgtgcgggtt gaggatgacg gaacgacctg cctttcgtat accatccatt acgaatacgt 893641 gtgtaaggaa caagatgaca gcttgtatat agaagagcac atagaggagc gaatggcttt 893701 cctgtatgat cacattttga ttagtgatca ggaaattgcg aaaaagccgg ctggatttca 893761 tgaagggacc agtattattg actattctga agctgaagag gaaagagaag cgtttggcag 893821 ggcttttcaa tacgatcgtc tcggcgctgt ccaatatgcc gagaaatttt ggaacaagcg 893881 caatcctgct tataaaaatt tcagcgataa ctgtacaaat tttatttctc agtgtcttca 893941 tgcaggaggc gcgccgatgc gcggtcatcc gaacagggga tcaggctggt ggatgaaaca 894001 aagctcatgg agctacagct ggacggtggc tcactctatg aaaatgtatt tgtcgaattc 894061 aaaggccgga ctgcgtgcgg tgcgggtgaa atcagcggaa gaactgatgc cgggcgatgt 894121 gatttgctat gacttcgaag gagacggccg gtttaatcat acaacgattg tcgtggcaaa 894181 ggacaaaggc aatatgccgc ttgtcaacgc ccagacttat gacagcagga tgaggtattg 894241 gtcatatgag gattctacgg catacacgcc gtcaatacga tatgcctttt ttcatatcgt 894301 tgatgatacg acaaaagagt aattaatgtt ataatgatgg gcggataaga aaaacagagg 894361 tgaacattgt ggcattacat gtcgttttat atcaaccaga aattcccgct aacacaggga 894421 atattgcacg tacttgtgca gcaaccaata caacgctaca cctgattcgt ccgctcggct 894481 tttcaacgga tgataaaatg ctgaagcgtg ccggactcga ttattgggag tttgttaacg 894541 ttgtgtatca tgattcgtta gaagaattgt ttgaggcata taaaaaaggc aagtttttct 894601 ttattacaaa atttggccag cagcctcata catcatttga ttacactgat cttgacgagg 894661 attatttctt cgtgttcgga agagaaacaa gcggtttgcc aaaggattta attcaaaata 894721 atatggaccg ctgcctgcgt cttccgatga cagagcatgt cagatcgtta aatctgtcca 894781 atactgccgc gattcttgtt tatgaagcgc tgcgccagca aaattaccgt gatttaaaat 894841 agtgaaaaac ccgctcatcg atgatgggcg ggtttttttg cggatgttga aatgctttgt 894901 ttcgtttttg ggcttaacaa cgtaacagtg ttatgttaca atgtacccat caaaggagct 894961 ggacttatgg aagaacaatt aatctctaaa aaagaattac ttgaaagaac atcgatttca 895021 tacggtcagc tgtatcgatg gaagcggaaa aacttaatac ctgaggaatg gtttattcgt 895081 aaatccacat ttacagggca agagacgttt tttccgagag aggagatttt aaaacgtata 895141 tcaatgattc aaaagatgaa agaaaatttg tctttggatg aaatgaggga aatgctgtcg 895201 ccgaaaatga aggatgtcag catgaccgct gatgaattgc ttcataaagg tttggtttca 895261 aggcctgctc ttgaagccta ttcagaagac ggaggaagtc cggttttttc atccagcgat 895321 ttgctttcgc tgtttgtgct tgagggcctg ctgcagtctg gaaatgtcag ccttgcagaa 895381 gcaaaaatgg ctgcagaggt attaaagaag catgatactg aagagattga aaaacagacg 895441 gagctgattg tgctccgcaa gctcggtgtc acaacttgtt ttatagcggc tgcggcggac 895501 agcattttgt ttgaatcatc cgtaaaggtt gtggaacggg tagatttatt aaaagcttca 895561 gaggaattaa aaacaacatt tatgcaggag ggccatcaat ggatgtagtg gaaaagctgg 895621 tgataaatgg atcaggaagt tctaagggag gaacatttca atcagttgag attaatggca 895681 gcgggacagt ggccggggac gtggagtgtg acactttttc ttttaatgga aacggaaaag 895741 cggacggcag cgtcaaagcg aaagcggtaa ctatcagcgg ttcaggaaag atacatggag 895801 acgttgaagc agaatctatc cggatgaatg gcactggttt tattcaagga gaggtatctg 895861 caaaacaatt gaaaatcgct ggatcatcaa catttggcgg cactgtcaag gctgatggaa 895921 ttgacattag cggaaaagct gtcatggaag cagattgtga aacagaaacc tttcaatcag 895981 aagggaaatg caaaatcagc gggcttttaa atgcagacca ggtgatcatt aagctttctg 896041 caggggaaag ctatgcgcgg gagatcggct gccgccatct tcaagtgacc tgcagaaaag 896101 gaatgctgac attgctcaga ttgatgccgc agcctgttct aacagcagag ctgatcgaag 896161 gtgacgtgat tgaattgaca aatacaaagg cgaaaaccgt gcgcggtaat aaagtgatca 896221 tcggcccgga ttgccagatt gaaaccgtcg aatacagcgg ggactatacc tgtgatccaa 896281 gcgcgtcggt tgaaacatcc acaaagttgt aaggaggatc gtaatggaga caacaaaact 896341 gggaaattta aaattatatg gcgctgggca tgccgcagga ggcgcgtatc acaatgtcag 896401 catcaaagga gaaggtatag ttggagaagg gctgtctgct gtaggctgcc gcatatacgg 896461 aacgggcctt tttctcggaa aagcagagac tgagcggctg cgtgtgctcg gagaaagtga 896521 atgtaaaggc gatctgacag ccggcaaaat caatatatat gggacaatga aagtcagcgg 896581 ctcacttcaa tttgatcgat tcaatctgaa aggccagact gaaattggcg ggaatatgac 896641 tggagaatcc tgcgatgtga aagggaagct tagcgtaata ggtgattgtg aaacagaaat 896701 gttccatgtc acaggctgtg ttgatgtatc ggggttatta aattcgggtg agatcaagct 896761 gggattgagc catgatataa gccatgtgca ggaaatcggc ggaacaacaa ttacagtgaa 896821 aagacgcgcg agttttttta gccggaagaa agggaagctg atcgccgatg tcatagaagg 896881 agatcgggtt tatttggaga ataccgaagc ggcagttgtc aggggaaaag aagtgatcat 896941 cgggccggga tgcagcatcg gaacgattga gtacgaatac aaatgtgaat gcgatccgca 897001 ttcacagatt aaagaaaaaa caaaactgta aaacattgtt ctgttataca aaaagggtgc 897061 tctttcagga gcaccctttt ttattctttt ccaggcttgc tttcgtatcc tgcggtaaaa 897121 attgatacta aaaaagtgac aatgacaccc atcatgatga ttgttttcac cgtctctccc 897181 cctcttcaat ttttccgtgc tgtccgagtc tggatgattc tgtatttttc tttattatga 897241 acggtcgcag tctgccttgt caacgatgta tgagtatctt tatttttaag aaaccaaagc 897301 atgtatcacg agatggcggc atagattgta tcaaagtacc ttatttgcat agtgtatcaa 897361 acatgataga ggaggtcctt atggatatat taaagaaaat tgaaaagtac agagaggaag 897421 agcagcggct gaaatgggaa ggaactttcg ccgattattt ggagattatt aaagaaaatc 897481 cgatggtcgc gcaatctgct cattctcgag tttttaatat gataaaagac agcgggatag 897541 aggagattga cggacgcaag aagtacagtt tttttgaccg cgagctgttc gggcttgaag 897601 aatctctgga gcgtcttgtg gaagagtatt ttcatccggc tgccaaacgt ctagatgtca 897661 gaaagcggat tctattgctg atggggcctg tgagcggcgg taaatccacg ctggtcacaa 897721 tgcttaaaaa aggtctcgaa gcgtacacgc tgacagataa tggcgctgta tatgcgatta 897781 aaggctgccc gatgcacgag gaccctctac atttaatccc ccatcattta cgcgatgact 897841 tttacagaga atacggcatt agaatagaag gaagtctttc tcctttaaat gtcatgaggc 897901 tggaggaaga gtacggagga agaattgagg atgtgaaggt ggagcgcatc ttcttttcag 897961 aagataagcg tacgggaatt ggaacattca gtccctctga tccgaaatct caggatattg 898021 ccgatttgac ggggagtatt gatttctcaa caatcgccga gtacggttca gaatcagatc 898081 cgcgcgctta tcgatttgac ggagagctga ataaagcgaa ccgcgggatg atggagtttc 898141 aggagatgct gaaatgtgat gagaaatttc tctggcattt gctttccttg acacaggaag 898201 ggaattttaa agctgggcgg tttgcgttaa tttctgctga tgagctgatc gtggctcaca 898261 cgaatgaaac ggagtatcgc tcatttattt ctaataagaa gaatgaagcc ctgcactcaa 898321 gaatcatcgt gatgccggtt ccttataatt taaaagtgtc tgaggaagag agaatttatg 898381 aaaaaatgat tgcagaaagc gatgtggcgg atgttcatat tgccccgcat acgttgaagg 898441 tcgccgcgat gttctcaatc cttacccggt taaaagagcc gaagcggtcg gatattgatc 898501 tggtcaagaa aatgagactg tatgatgggg aaagtgtgga aggatataac tctgtcgacg 898561 ttgaggatat gaaaaaagaa tataatgatg aaggcatgag cggaattgat ccgcggtacg 898621 tgatcaaccg gatttcttca acgattatca gaaaaaatat ggaatcgatt aattctctcg 898681 atgtccttcg ctccttaaaa gaaggtcttg atcagcaccc atcaatttca agcgaggaca 898741 gggagcggta tttgaatttt atctctgccg cccgcaagga atatgacgat attgcgaaaa 898801 aggaagttca aaaagcgttt gtttattcat atgaagaatc agcaaaaaca cttatggaca 898861 attacctcga taacgtagag gcctattgca ataaaaacaa gcttcgtgat cctttgacag 898921 gagaggaaat gaaccctgac gaaaagctga tgagatccat cgaagagcag atcggcattt 898981 cggaaaacgc caaaaaagcg ttccgcgaag aaattttaat ccgcatctcg gcctatgcga 899041 gaaaaggcaa gcggtttgat tacaattccc atgaaagact gcgtgaagct attcagaaaa 899101 agctgtttgc tgatctgaag gatgtcgtta aaattacgac ctcaacaaaa acgccggatg 899161 agcagcagct gaaaaaggta aatgaagtcg tggcccgttt aattgatgag cacggctaca 899221 actcgacgag cgccaatgag ctgctgaaat atgtcggcag cctgctgaac cgataagcaa 899281 cgtgacccgt ccgaataggg cgggttattt tgtcccattt tctaaatagt ttgtcaatta 899341 aacgtgcata tgtgcatatg atgaatataa atcttttcaa aagacttgtt tcataatctg 899401 gcacaagccg gaatacgtat gtatcacgac cacaaatggt taaggagggg aattcatgtc 899461 ccaaaatgac agcggccatt ttttgatttc tgaggaaaac tggtccctcc atcgcaaagg 899521 cttcgatgac cagcagcgcc accagaaaaa agtgcaggaa gcgatcaaaa acaatcttcc 899581 ggacctcgta actgaggaaa gcattattat gtctaatgga aaagatgtag tgaagatccc 899641 aatccgttca cttgatgagt ataaaatccg ttataactat gataaaaata aacatgtagg 899701 gcaaggagac ggcgagagcc aggttggaga tgttgtggcc cgggatggat cagacaaaaa 899761 acaagggcct ggaaaagggc agggtgccgg tgatcaggca ggcgaggatt attatgaagc 899821 ggaagtttca ttaatggatt tagaagaagc gctttttaaa gaattagagc ttccgaatct 899881 ccagcaaaaa gagcgggaca atatcattca tacagatatc gagtttaatg atatccgtaa 899941 aacagggtta accggtaata ttgataagaa aagaacgatg atgtcagcct ttaaacgaaa 900001 cgcaatgtca ggaaaaccgt cgttctaccc aatttatccg gaggacctga aatataagac 900061 gtggaatgac atcacaaagc ccgaatcaaa agccgtcgtt ttagccatga tggatacaag 900121 cggcagtatg ggggtttggg aaaaatacat ggccagaagc ttctttttct ggatgacccg 900181 ttttttgcgg acaaaatacg agactgtgga aattgaattt attgcccatc atacagaagc 900241 aagagtggtc tcggaggagg attttttctc aaagggagaa agcggcggaa caatttgttc 900301 ttccgtatat cggaagtcgc ttgagcttat tgatgaaaag tacaatcccg cccgctataa 900361 catttacccg tttcattttt ctgacggtga caacctgaca tctgataacg cgcgctgtgt 900421 gaagctggtc aatgatatta tgaagaaggc caatctgttt tgctacggcg aggtcaatca 900481 gtacaacagg cattcaacgt taatgtctgc atataaaaat gtaaaagatg agaaatttaa 900541 gtactatatt ttaaaacaga aatctgatgt ttttcaggct ctaaagaact ttttcagaaa 900601 tgaagagtct ggtgtaagcc atcaattttc gtaatgaaaa gcccatttca gggctttttt 900661 ttatttaata aaagcaagaa aacgcttgcg aaaaaaatac gggagaaaaa gaaatttttc 900721 ctttgacaaa tcttctttca tttattaata ttttatcttg tgaactatta ttgaggaatg 900781 aggtgaaaag gagttgactg aatcagaacg tgctttgctc acttttgaac agctcttcga 900841 tacgtctcgg gcgatatata aaaaacagaa gaagatattg gagattgtgc ttgagccttt 900901 tgatattaca gtccttcaat atttgctgat gtttaaaatt catcaaagcg gaagcacccc 900961 gctaagcaag ctggcaatgt cgcttgatct taagcctgct tctgtgacgc ggatgacaga 901021 tattctgtat aagcgccaat tgatgaatcg atatgacagt ccggatgacc gccgtatcgt 901081 catgattcag ttaaccgaag agggggaaga actgatagaa aaagccgctg tgcaatatgc 901141 aaaaatgggt gctggcttgt accaaaagct tgatacctcc cagctgcagt atttgcgcaa 901201 actagccgga agtttaacga agcttgctga aggctgttca gaaaaaagcg gtaattaaaa 901261 acttctcaca tattttcacc agctttccgc aaaatgatag aggatgaaac gaaaggagaa 901321 aacaaaatga acagaggacg tttaattctg accaacatta tcggtttgat tgttgttctt 901381 gcaattatag ctggaggtgc ttactactat tatcaaagca caaactacgt aaaaacagat 901441 gaagcaaaag tagcgggcga tatggctgct attactgctc cagcagcagg taaagtatct 901501 gactgggatc tggacgaagg aaaaacagtg aaaaaaggcg acacagttgc aaaaatcaaa 901561 ggtgaacaaa ctgttgacgt aaaatccatt atggatggca caattgtgaa aaacgaagtg 901621 aaaaacggac aaaccgtaca agctggtaca acaattgcac aaacgattga catggacaac 901681 ctatacatca cagcaaatat taaagaaaca gatattgcgg atattgaagt aggaaatagt 901741 gtagacgtag tagttgacgg agaccctgat actacatttg acggtactgt agaagaaatt 901801 ggttatgcga ctaactcaac ttttgatatg cttccttcta caaattcaag cggaaactac 901861 acaaaagtaa cacaaaaagt tcctgtgaaa atttcaatca aaaacccatc tgataaggtg 901921 cttcctggaa tgaatgcatc tgttaaaatt tctgagtaaa acagatcagt catcaaacca 901981 tgaaaggagg ttgtcttaga tggctacagg caaagaaaaa aatgcaaaaa accctatgtc 902041 attgctgatt gtgctaatgg cgggtttatt tttggcaatt ctaaaccaaa cactgcttaa 902101 tgttgcaatg ccgcacttaa tgactgaatt tggcgtaagt gcaacgacga ttcagtggct 902161 gacaacaggt tacatgcttg ttaacggtgt attgattccg ttatctgctt tcctgattac 902221 acgatttggc cagcggagtc tctttctcgt cgcgatgttt tgttttacgc tcggtacgtt 902281 agtctgcggt atcgcaccta acttctctac aatgctgatc ggccgtttga ttcaggccgt 902341 gggcggaggt atcttgcagc cgctcgttat gacaaccatt ctgttaattt tcccgcctga 902401 aagcaggggg aaaggaatgg ggattttcgg gctagcgatg atgtttgctc cagcggtcgg 902461 cccgactctt tccgggtgga ttattgagca ttatacatgg cgcattatgt tttacggact 902521 tgtgccgatc ggcgcaattg ttatcattgt ggctttcttc atctttaaaa atatggtgga 902581 gccgcaaaaa atcaaactcg atactcttgg cgcaatcctc tcgattgtcg gattcgcctc 902641 cttattatac ggagtcagtg aagccggatc tgacggctgg accgacccga ttgtattgtc 902701 tacagttatt atcggagcca ttgcaattgt tgcttttgtt gttcagcaat tgcgtcatga 902761 tgatccgatg cttgatttca gagtgtttaa atatgacatt ttctcactct cgagtgtcat 902821 taatatcatt attacagtgg cactttacac tggtatgttc cttttaccga tttatctgca 902881 aaacctggtc ggctttacgg cgcttcaatc cggtctgctt ctgcttccgg gtgcgatcgt 902941 tatgctgatt atgtcaccga tctcaggtat tttgttcgat aaattcggac cgagaccgct 903001 tgcgattatc gggcttctcg tgacagtggt aacaacgtat caatacacgc aattgacaat 903061 tgatacacca tatacacaca tcatgctgat ctattcaatt cgtgcatttg gtatgtctct 903121 cttaatgatg ccagtcatga cagccgggat gaaccagctt cctgcccgtc tgaacagcca 903181 cggaacggcg atgagtaaca cgcttcgcca aatcagcgga tcaatcggaa caagtttaat 903241 tacgacgatt tatacaaacc ggacgacatt ccattattca caaattgcag ataaaacaag 903301 cacggcggac ccgaacttcc tccatgcgtt ccaaaatgca gtttcgaatt taatggtgaa 903361 tatgaatgtg tcttatgata cggcgaaaac atatgtgtac tcacatattt ataaacacgc 903421 atcactcgat tccaatgtca tggggataaa tgatgccttt atgtgggcaa ccttattctg 903481 tgtagcaggt ttgattttaa gtatcttcct gcgtgacgtc agaaaagata aattgcgtaa 903541 gaagaaaaaa gaggagcttt cattacttcc tgctccaaaa gaagctaagg aatcttaatc 903601 tgtacaggga ggtttcctga atgaaaattt atgtagtgta tgatagtgaa ggcgaacata 903661 ctaaagtgct tgcagaagcg attgctgaag gcgcgagaga aaacgacgcg gctgaagtgt 903721 tcatcgacca tgtagatcag gctgatatcc gcaagcttaa agatatggat gcgattattt 903781 ggggatgccc agggcatttc ggaacaatca gctccggtct taaaacttgg atcgacagac 903841 ttggctactt gtgggctgaa ggcgagctga tcaacaaagt cggtgctgtc ttctgcacaa 903901 cggcaacaac acacggcggc ttggaaatga caatgcacaa tttaatcacg ccgatgttcc 903961 accaaggcat gattgttgtc ggactgcctg gcaacgtgcc tgaaaacgca ctttatggct 904021 cttattacgg agcaggtgtc acttgtccgg tagacagtga tgagttaatg tctgaggaag 904081 gtattcagct tggacgcgcg ttgggaagac gtgtcagcca agtcacagga aacctaacag 904141 caggacagta aggagaggtt gaaatggcca ttattatagc aataattgct gctgtcattg 904201 tcattgcggc ccttattaca tttaacgtcc gcaacgcctc acctggacct gagaagcaag 904261 aagcaaccga tagaatcgca cctccagaag aggaaaaaaa cgaagcgcat taccctgctg 904321 aagcaagggc tgccgagcat acgccatccg ttgtcaaaaa cgattctcca aaagagaagc 904381 gtgacacaat gggtgatgat atttacaggc aggcgctgca aaagtttaag cattctgatg 904441 aagttcatgc agaagaagag gtcactgagg aaagtgacaa aatgcaggac cgcagctatc 904501 gtgatgcgct gctctctatg aaaaataaga aaaagtaatg aaaaaggcaa atccgtttac 904561 tcatgcgggt ttgccttttt tgctgtttcc atcaattatg tttttatcaa ataaatccat 904621 ggaatatgtt gtattccacc ttgatctagt gtactatgtt actcatacac cgaggatttt 904681 ttccgggagg taaagacatg aattcttttt taggtttatt aaagaaagat atcaagcttt 904741 caagaatgtg gctgctagta tggatatgcg gaatcatttt cttattggga acaggccata 904801 ttatagcttc tcgcacgaaa gaacctctag tcatttttgg tttttttgtt gcagttgctt 904861 tttttctgct tttcttatct cctgtttttg ttttttatca ccttcgcaag gaagggaaat 904921 cacagctttg gctgtacaat ccaaatggcg gcttatggct gttttcttct aaattggcag 904981 catctttgct ctatcaattt gtgattcagt tggcattaac agcctatggc atatggatgt 905041 atcatatgct ctctgtaaaa aatctgctgg agcatcaagt tgatataacg agtacagtgg 905101 ctttgctgaa tatgtatggg cttatttctt cgttagatat gtcagtaaca gtcattgtgt 905161 tttggactgt ttttcactct ctcagaaatt ggcgcggaat gcggtgggct gcgatggttc 905221 tgttggtcgc aatgtggtta ttcttcgatg aatacatcat aagccctttg gttgaatctc 905281 aaaagcattt ctggcctgta acagtctatt gcaattttga tttccacttc cacaatgttt 905341 ggagattgga actaaaacct atccatctgt ctgtgctagg gtttcctatt gctatagtca 905401 tcacattctt gctgctcatc atggcttcaa aactgcttga tcgtaaagta gaggtgtaaa 905461 tatggacaat caattccaat cctcgaaacc gatttatctg cagatcgctg atcagatctt 905521 ttataggctg gtcaggaagg agctgctccc aggagacaag cttccttcag taagagaaat 905581 ggcgattcaa actaaagtaa atcccaatac aattcaaaga acttacagtg agatggaaag 905641 gctgggtatt gtggagacaa gaagaggtca agggacgttt attgcggaaa aagcagaaat 905701 cgtagacgag ctgaaagaca agctgacacg agaggtgctg gaaggctttg tcaagcaaat 905761 gaaagagctg gggctaacga aagaagaaat gttagaaggg attaaaacat tcacagaggg 905821 aggctaaaat ggaaatcaag ctagaacatg tatcaaaaaa atacggccgc catacggccg 905881 tcaatgatgt gtcaatcacc ctatcatccg gacggattta tggcctgatt ggaccgaacg 905941 gcagcggcaa gtcaacgacc ctgaaaatga tggctggcct tctgtttccg acttcaggat 906001 ttgtaaaagt tgatgaagag caggttacga gagaaatggt gcgtcaaacg gcttatctta 906061 ctgagcttga tatgttttat ccgcatttca ctgttaaaga tatggtgaat ttttatcagt 906121 cgcagtttcc tgattttcat acagaacagg tttataagct attgaatgag atgcagctga 906181 atccggaaaa aaagatcaaa aagctatcaa aaggaaatcg gggcaggctg aaaatcgttc 906241 ttgctttagc gagacgggca gacgtcatct tgcttgatga acctttttcc gggcttgatc 906301 cgatggtcag ggattccatc gtaaacagcc ttgtgtcgta cattgatttt gagcagcaga 906361 ttgtcgtgat cgcgacacat gaaattgatg aaattgagac tttgttagat gaagtaatca 906421 tcctcgccaa tggagaaaaa gttgcgcagc gtgaagtaga agatattcgt gaacaggaag 906481 gcatgtctgt tttgcaatgg tttaaatcaa aaatggaagt ttgctagaaa gaggaggaat 906541 atgatgaaaa cagtgttgga attgaaaaac gtgactaaaa acatcagagg ccgaacgatc 906601 attgatgatc tcagttttac gattcgtgaa ggcgaggtat tcggtttttt aggaccaaac 906661 ggagcgggga aaacgacaac catccggatg atggtggggt taatgaagct gtcgaaaggt 906721 gatgtcctca tttgcggcca atcaattacg aaagaatatg ccaaggcgat taagcatatc 906781 ggagcgatcg ttgagaatcc cgagctgtat aaatttttga gcggatataa aaatctccag 906841 caattcgcaa ggatggtcaa gggtgtcacg aaggaaaaaa ttgatgaagt tgttgaactg 906901 gtcggtttaa cagacagaat ccacgacaag gtgaaaacat attctctggg gatgagacag 906961 cgtcttggct tggcacaatg ccttctgcac gatccgaaag tgctgatttt ggatgaaccg 907021 acaaacggcc ttgatccggc ggggatcaga gaaatcagag atcatttaaa gaagctgacc 907081 cgagaaagag gaatggctgt catcgtttca agccacctgc tgtcagaaat ggaactgatg 907141 tgtgatcgaa ttgcgattct gcaaaaagga aagctgatcg atattcaaaa tgtaaaagat 907201 gaaaacattg atgagaatga tacatatttc ttccaggttg agcagccgag tgaagccgct 907261 actgttttaa atcagtacga tttgctgagt aagacaaatg gtgtagaaat caaactggct 907321 aaagaggaag tccctgcggt tattgaattg ctggtgatgc agcaaatccg tatttatgag 907381 gtcaaggtca taacaaaatc attagaggac cgtttcttag aaatgacagg tgaaacaaaa 907441 gaggaggttc agcatgctta atttgattta taatgagtgg ctcaaaattt tcagccgtgc 907501 cggaacatgg gtgatgatcg gaattctggg gctgacaatg gttggatttg catttttggc 907561 gaatcatttt tctgccggtg aatcaaattc ccattggaaa caagagcttc aagcacaaaa 907621 cgccgaatta aagaaagaaa tcaaagaaga tccttcactg aaagatgggt ataaagaaac 907681 aatcacactc aatgactatc gcatcgagca taatatccct agtgacacgg gctatacggt 907741 atggtcttat gtaacggatt cagcaaactt taccatcctt accggtctgt ttactattat 907801 catcgcggcc ggaattgtcg cgaacgaatt taattgggga acgattaagc tattaatgat 907861 tcggccgctc agtcgttttc aaattttgat gtccaaatat attacagttc tcctgtttgg 907921 gctcctgttg ctgttgattt tatttatcgg ttctacttta ttagggttga tcttcttcgg 907981 aacgggtggt gaaaccgccg cgaatattca tttaatctat aaggatggcc atgtcattga 908041 gcaaaacatg atggggcatt tggctacaac gtatctttct gaatccgtct cggctttaat 908101 ggtggcgacg atggcgttta tgctgtctgc ggtattcaga aacagctctc ttgcggttgg 908161 tttttccatc ttcttgttgg ttgccggtac gactgcaact gcatttattg cagcgaaatt 908221 tgactgggca aagtatatat tgtttgctaa tgtcgacttg actcagtatg tggatggcac 908281 accgttaata aaagggatga ctatgacgtt ttctctcgtc atgctggcga tctactttat 908341 catcttcctg ttgcttgctt tcggaatctt catgaagcgg gatattgcaa actaataaaa 908401 aaagctgttt tgcttatgca aaacagcttt tttgtcaaaa taaaaactgc aggtttgcac 908461 ctgcagtttt tcatatcaat ttatgcttac gcttctttag taacgttagc agcttgtggt 908521 ccgcggtttc cttcaacgat ttcaaaagaa acagcttggc cttcttctaa agttttgaag 908581 ccttcgcctt gaatagcaga gaaatgaacg aatacatcgt cttgaccttc tacttcgatg 908641 aatccgaaac ctttttcaga gttgaaccat tttactttac cttctaacat gaaatttcct 908701 cctaaagcga tcataacgct taaattcact attcttgctc ttaacaaact ttcaagacga 908761 aaactcttac aaaactttct tcttaaagat agttcgaaca aaaataatta cctttactct 908821 accagtaatc ttcagaaaaa acaactgctt attgaaattt ttttcggaaa ataccatatt 908881 tatttttcaa tttgatattt atttacggaa attcatctgt tttctcgata tgtgatcata 908941 cgtttgcctt agtattcctt cattttggga agataagtaa taggaattga caaccttatt 909001 ggatatgagt aaggtaaaag ttaatcaata ttacaaatga caacgtttat caactaagag 909061 agcgtatgat ttttatgtct gatattgctt gcatgctcta atacatagat aggagtatgg 909121 tcacaatgaa aaagtggctt atatgcagtt tcgtccttgt tcttctcgtt tcatttactg 909181 catgttcacc gtctgcagaa catgaatcga taaaaatcgg gattgctgag tctgacgggg 909241 caatatggaa ctatattgct caaaaggctg aagaggcagg gctggatatt cagctgatcc 909301 ctttttctga ttatgcggag tctgatatcg cacttgctaa caaagaaatt gatgccaacg 909361 cctttcaaac catttcatat tttcagtcgt tcactgaaaa atacaaactt aatttggcac 909421 cgctcgggac gacatacata acgcccatgg gcatttattc aaaacgatat gaacgaatcc 909481 gagatatatc gcggggagct gtcgtttctg ttccggataa agcgttcgat tttggcaggg 909541 cgcttacggt gctccaggaa gcgggtttgc taacgctgaa aaacggattt aacggaacag 909601 gttcagttga tatgattaaa gataatccga gacacctgaa attaaaagct gtccggcaac 909661 aggatgcagt gagcggtgcc gacgtgtttg tcatgaaacc atcagaagca aaaaaagcgg 909721 gcttgaaccc gaaaaagcat acgctaaaga gcggcggact catgtctgag gaagagatga 909781 atttgattgt tgtcagagcg gaggatcaag atcgggaagc gctgcaaacc attcttgagc 909841 tttatcaagc tgatgataca gcggcattta tagaaaaaga atatcaggga gatcttgtcc 909901 cggcttttct gcctttgaaa cgtctttcag attggaagaa tgaattcgaa cattgaattc 909961 attctttttt ttctgaaaaa cacactctgt tccgtcccgt ttctttcgct ttgtaaagca 910021 tttgatcggc aagaatgggc aaggatcctg gctgttccgt attattgggg taatgagcgg 910081 cccctagtga tatcgtaact gaaagctcgt cgccgtttgt taatacaatc ggtgcatcac 910141 ttacagtgct cctgatccgt tcagcgatcc gggctgcttt atcaagagaa cagttcggca 910201 ggagcacggc aaattcttca ccgccgatcc gagcggcagg atcagtattt cggatggtct 910261 gcttcagacg taaccctagc tctttgagca cctgatctcc ttcatgatgg ccatattggt 910321 cattgatggt cttaaaatga tcgatatcca tataaatcag tgcaaattga aaatgcgggg 910381 tatcggccgc ctgctgatac agagcttttg tggtttcttc aaattttctt cggttataca 910441 cgcctgttaa aaagtcaaag tgcgcctgaa acttatattg tttaaaaaga agatgtgcat 910501 ttgtttcatg atcaataata tataaactga gcatgccgcc cgctattgat atgatccaaa 910561 aatacaaatg aagttcgtat gaatgtaaat ctataagaaa ataaaaggaa aaggagatca 910621 agctatttgt gattattaaa agatagaaag catgttttag ttgaactttt tttcttctag 910681 aaacaatgag tgacggaatg gcagcgatac aaatgataat aaccgagtat agtgcagatg 910741 tgttcatcgt aatcagcaag cggcctgcag tgatcatggc cagggccgtt gccgttgaaa 910801 cccagcctcc ataaagagcg gcaatcataa tagggatatt tcgaagatca ataattgaat 910861 gctgataggt aaatccaaaa accatcagaa taaccccgag caaaccgcag gccagtcctt 910921 taacagcttg aaaggatatg ctgtcttttt tatgtactag cctttcttta aacaggtggg 910981 tgaagagata attaaatgtg attaaaatgg tcaaatttac aaacagttct ttcagcaaat 911041 attatcaccc ttatataagg tactaaagat ggaagggaaa gaaaagaaca aaaaaggcat 911101 tatataaggt ttttttactt gaattgataa gttaaaataa ttcgcacttg acccatcgga 911161 attagtgtaa tatagtaaat gagaaaattt gaagggagag tttacctgct ttggagactt 911221 tactggttgt attacatgta tttattttat ttttacttat cttagggctc tttgttatgc 911281 agaaaaaaca tgtttccttc tctaaacgtg tatttactgc gctggggctg gggattgtat 911341 tcggatttgc gcttcagctg atttacggcc cgacttcaaa tatagtcatt caaacagccg 911401 actggtttaa tattgccggg ggcggatatg tcaaattgct tcagatggtt gtcatgccgc 911461 tcgtctttat ttcgattctc ggcgccttta caaagctgaa gctgacaaaa aatcttggga 911521 aaatcagcgg tttgattatc gggattttag tagcaacaac agcagttgct gcagctgtcg 911581 gtatcgcgtc cgcgctttca tttgatctgc aggcgattca ggttgaccaa ggaagtacag 911641 agctttcacg gggacaggag cttcagcaga aatcagagga tatgacagcg aaaacgctgc 911701 cgcagcagat tgttgaactg ctgcctggaa acccgttttt agattttacg ggagctagac 911761 cgacttcaac gatcgctgtc gttatttttg ccgctttcct tggagtggca ttcctcggcg 911821 taaaacacaa acagccggaa caggcagaaa catttaaaaa actggttgat gccgtttatg 911881 ccattgtcat gcgtgttgtc acactcattt tgagactgac gccttatggg gtgctggcca 911941 tcatgacaaa aacaattgca acgagtgatc ttgacagcat tctaaaactg ggcatgttcg 912001 tgattgcatc atatgccgcg ttaatcacta tgtttatcat tcatttgctg ctgctgacgt 912061 tcagcggctt gaatccggtg atttatttga aaaaagcggt gcctgtactt gtatttgcat 912121 ttacgtcaag gtctagcgca ggtgctttac cgctgaatat taaaacacag agaagcatgg 912181 gtgtaccgga gggaatcgca aactttgccg gttcgttcgg tctttcgatc ggccaaaatg 912241 gatgtgccgg catttatcct gcgatgctgg cgatgatgat tgctccgact gtcggccaaa 912301 atccatttga cccggtgttt attatcactg ttatcgcagt cgttgccatc agctccttcg 912361 gggttgccgg agtcggcggc ggagcgacat tcgcggcgct tcttgtttta tcatcattaa 912421 acatgcctgt cgcgctcgcc ggtttgttaa tctcaattga accgttaatc gacatggggc 912481 gtactgcttt gaatgtcagc ggaagcatga catccggtct tattacaagt aaggtcacaa 912541 aagaaattga tcaaggggca tttcatgatc aatccagagt gattgaagct gaagaagcgt 912601 aacatatgaa aacgtgtaat ccaagaggat tacacgtttt tttaacggcc aggctctaag 912661 tcctccagca tttccatcat cgtgttgtcg tccatgacat tcattgcgtt ttgttcaaaa 912721 tgaatgggtt cagcataatg cggctgtctt tttttcgcgg ctgtctcagt ttgcctagtt 912781 tgagactgtg tatgctgatg ctgtggttgc tgctgtccag cgtgctggtg ctgacggcca 912841 ttttgccgct ggctttgatg ctgcgaacgg tcctggttat caccgctgct tccgctgctt 912901 ccgctaaatg cttgtttgac catgtttcct acattagaag catcaaacgt gttattttct 912961 gaatttcgtc tgttcatttg tcctgtgata aacccgctga ttctttggcg gatctgaggt 913021 gataatgcag taataagcat agttgatcct atgatcaatg ctgcggggct gattcctctt 913081 cgctggttga acaacatgat ccctcctttg cagtgtattc atattttccc cctcgttaga 913141 caaattaacc gttatatttc ccgggaaagc atttcctcca gatttgcatg cataattaaa 913201 gccagttaga aaaacctata agtaaagtga taaaggagga attcacatgt ttggaaaaaa 913261 acaagtcctt gcgtctgtgc ttcttatccc tttgcttatg actggctgcg gtgtagccga 913321 ccaaggtgag ggcagacgtg ataataatga tgtaagaaac gtaaattatc gaaatccggc 913381 caatgacgat atgcggaatg taaacaatcg ggataacgtt gacaacaatg ttaatgataa 913441 tgtcaataac aatcgtgtaa atgacgataa taacaacgac cgaaaacttg aggttgctga 913501 tgaagcagct gataaagtaa cagacctaaa agaagtaaag catgccgata tcattgtggc 913561 tggaaatcaa gcctacgttg cagtcgtttt aaccaatgga aataaaggtg cagtagaaaa 913621 caatctgaag aaaaaaatag ccaaaaaggt aagatctact gacaaaaaca ttgataatgt 913681 ttacgtttca gctaaccctg attttgtaga gcgtatgcaa ggatatggaa agcgtattca 913741 aaatggtgac ccaatcgccg gattatttga tgaatttaca caaactgtac agcgtgtatt 913801 ccctaacgct gaataaatga aagaagccgc acaatttgtg cggctttttc tttgcgttaa 913861 tgacacactg cgaactcagg ctgcatagag taaaaataaa aaggtacaag acggaccggc 913921 tcagggaggg agacgtttgc gggatggcat aggaaagcgt gcggcatccg ctctattcct 913981 gtgcggagtc cttgtgatgc tggctgtaag ctcagccatc gtatcaagcg cgatgtatat 914041 cctgtctttt ccaggtcagg catctggaat aacaaaagaa caagtgacga agcacatgaa 914101 gaaagagtca ttcaaacagg ccgatattta ttacacttct aaggaaaagt ccttactgcc 914161 attgacgaaa gaaacgcttg aatatgcggt cagtattaat cagattatga ttggatattc 914221 gaatcaaaag cctattgaca ttattttttt tcctaatgaa aaacagatgg aggcttactc 914281 cggtttattg gatgtagttg gtttttattc tgaacgggag cagctgatcg gattgttgcc 914341 tgaagagaaa aagaaactgt tagaagggga cgaggtagcg gtttatttgt accagagatt 914401 gttgattcat gaatactcgc accatgcgtt tcaccagaaa ttgaaggagc ttgagacgga 914461 tcccgatgag tttccgttat ggtttcatga agggttaagc gagtggattg cgaactatga 914521 attgctcata gatccgatca cgttttctgt cgtgcccttt gaccgtttgc agactgatcg 914581 agactggcag gaagctagag ccgaatatga cactgatgtc tatttgcaaa gcttttatat 914641 gatcgatgag ctgacggaca aatacgggaa agacattatt tcagaaatga ttaaggaaac 914701 ggcaaaaaaa ggggactttg aaaaagggtt taaatcagca acaaaggaaa gtcttgatca 914761 atttgaaaaa gattttaaga aaaaatttga aaaaaacagt gcggcattgg atagtatcta 914821 tccaatgcct ttgttattag tgaagtcctt gctgacccat tccgccttgt gtcggaggca 914881 tttgtccttg ggcaggggcg aatgaatttc gcagctgttc catatcctgc gcatcaagct 914941 gaggaacctg gtaatagccg tgtttgtttt ggtataggaa aatttcaaat gccatttcaa 915001 catactcctg aatttgcgca gacagtacgc gtcttacggc cggatttgtc atttccagag 915061 aagccatcgt cagcatagaa gcttgtgctt taatcgcgca aagcatttgt cggctgatga 915121 tgctgtcatc aatatcattc atggattgaa caggtttttt aggctgtgac ggctgcatgc 915181 cgtaaacagt ctggttgtct tccttcatca tataagttgc tgttttttgt gaaggttcgc 915241 ttcctgtttt gaagcattct gcagttatat tgtattgaga tgtgatgaat tgatgttgac 915301 gatcaaggat gtttagtaat tcttgatcct tacagaattg tctcagcatc ataaactgat 915361 caagcacagt aagtgttccg gaaagcacct catgcatatc aaacatttca tgtccgccgt 915421 ggtttttatg cggtttgcca ggaatacctt tgttcatttg ggattgctgc tgctgattga 915481 actgatccaa accgaattcc tccttttttt tcagatcagc tgtattttgt gtcagtctgc 915541 cgtgtattat gcagaagcct gaaaggaatt atatgctgtc tgtcgaaatg ataagcagac 915601 aaaatcgttg tcattatgtg tataagggag gaaatatgat gaggcgtatt ctgcatattg 915661 tgttgatcac ggcattaatg ttcttaaatg taatgtacac gttcgaagct gtaaaggcag 915721 ctgaaccgca acagcctata tcgattgaga aggcaataca gcaaaaagaa ggacaggcac 915781 ttgtcgaagg atatgcagtc ggccaggctg tttccccgca gcattataaa ctgacaagcc 915841 ctttttcaaa tgattataat gttgcgctgg cagaccgtaa aaacaaaaca tcgcccgaac 915901 acatccttcc tgtgcaaatc ccctccgcct tcagaagcca atttgggctg caaaccaatc 915961 cgcttcttct tgggaaaaag ataacggttc aaggaaagct tgaaaattac tttaacacga 916021 caggacttaa aaacgttcag tcgatgaacg taaccgatga cacaaaaact ccgccggctg 916081 aacagcaagt gaccataaat gaagcacggg gaaggctgaa tgaagaagta acgataaaag 916141 ggatcattac agctgatcaa aacgcaatcg gaggcgggaa gctgtcgacc tttttgcaag 916201 atgaaaccgg aggcattaac atttattcgc catcccctga acaatttccc gaattaaaag 916261 agggtatgga tgtcacggtg acagggaaaa tcacgtctta ccaggggctg aaagaaatcg 916321 ttccaaactc atcaggcatc aaaatcaacc agtcaaatca atccctcccc gcccccaaac 916381 acttaacaat caatgaactt attaacggca gcctaggtga tcagtatgaa ggacgccttg 916441 tgaaactaac cgcttttgtt tcctcaattc caagttctcc tgccggcggc ggttacaatg 916501 taacaatgat tgatgacgac catcatgcaa tgacgctccg ggttatgaat gaaacagggg 916561 tgataaacga gcttgatgag ggcaaatggt atgaatttac cggtgtgtta agcagatacc 916621 aaacctttca gctgcttccg cgaaaatcgg ctgacctgaa gctgcttgaa gagcagcccg 916681 cacctccgtc tgcagaggga gaatatgaag ggattgttga ccgggtagtt gacggcgata 916741 ccattcatct taaatctccg gtgcttggaa cgacaaaaat ccggtttgta aatgtagatg 916801 cacccgaaac atatcacaca ccaaaaaatg acgcagatga aaatcaatta agatttggca 916861 aaaaagcatc tgactatcta aaaacggttc tgtccccggg tgataaaatt actgtcaagg 916921 tcgggagtga agccaaggac agctatggca gattgctcgg acaagtcata accgaatcag 916981 gttcaaacgt gaacttagag cttgtaaaaa acggctatgc tccgacgtat tttatttggc 917041 cggttgacaa tgaagaggat tatcagcaat ttcaggccgc agtagccgct gcaaaaaaag 917101 atcaaaaagg aatttggaat gaaaacgatc ccctcatgga aatgccgttt gaattcagag 917161 ccagagagca agggaaaggc ctgacaagat atgtggggga ctcgtcgaat aaaacatatg 917221 tgcagccagc tgactggaag aagatagctg tggaaaacag aattttcttc gcctcagcaa 917281 gtgaagcgga gagcgcggga tataaaaaaa ggcaaacggc acctcaagaa catgtgccgc 917341 ttagaattct cagcatgaat gatttgcatg gcaaaatcga tcagcaatat gagcttgatc 917401 ttgatggaaa tggaactgta gacggcacgt ttggacgcat ggattatgcc gccgcatatt 917461 taaaagaaaa aaaggctgaa aagaaaaact cgctgattgt gcacgcggga gatatgatcg 917521 gcggaagctc tccagtttcc tctcttcttc aggatgaacc gactgtagaa ctgatggagg 917581 acatcggatt tgatgtcgga accgtgggaa accacgaatt tgatgaaggc acggatgaac 917641 ttctgaggat cttaaatggc ggtgatcatc cgaaaggcac aagcggatat gatggacaga 917701 actttcccct tgtatgtgcc aattgtaaaa tgaaatcaac tggagagccc tttttgccgg 917761 cttacgacat cattaatgtg gagggcgtac ccgttgcttt tatcggagtt gtcacacagt 917821 cggcagctgg catggttatg cctgaaggaa taaaaaatat cgagtttaca gatgaagcaa 917881 cagcggtgaa taaggcggcc gaagagctca agaaaaaagg cgtgaaggcc atcgcggttc 917941 tcgcacatat gtcagctgaa caaaacggca acgccattac cggtgagtct gctgatcttg 918001 caaacaaaac agattctgaa attgacgtga tttttgccgc gcataatcat caggttgtta 918061 acggtgaagt gaatggaaaa ctgattgttc aagcgtttga atatggaaaa gcgataggtg 918121 tcgttgatgt agagatcgat aaaacgacaa aagacattgt caaaaagtcc gcggaaatcg 918181 tatatgttga tcaaagtaaa atcgaaccgg atgtcagcgc gtcagccatt ttaaagaaat 918241 acgaaacaat tgcggaaccg attatcagcg aggtagtcgg cgaagccgct gttgatatgg 918301 aaggggggta ttcaaatgac ggcgatacac ctcttggaaa cctgattgcg gatggtatga 918361 gagctgccat gaaaacggat tttgccctta tgaatggcgg cggcatacgt gaagcgctga 918421 agaagggtcc aattacgtgg ggagatcttt acaatattca gccgtttgga aatgtgttaa 918481 cgaagcttga gattaaagga aaagatttaa gagagattat caatgcgcaa atctcgccgg 918541 tttttgggcc tgactacagc atcagcgggt ttacgtatac gtgggataaa gaaaccggaa 918601 aagcagttga tatgaaaatg gcagatggca ccgagatcca gcccgatgcc acatatacat 918661 tgaccgtcaa caactttatg gcgacggcga caggagccaa atatcagcca atcggactgc 918721 tgggaaaaaa tccggtgaca gggcctgagg atttggaagc gacagttgag tacgtgaaga 918781 gttttgatga gccaattgcg tatacaaaag agggaagaat taagcttgct gaagccagtg 918841 atattgaaga ccctgtaaca gaagacccga taacggaaga gcctggagat gatccgggga 918901 cggaggatcc gattaaagag gatccaaggc caggtgaaga tttgcctgat ataaaagaaa 918961 ctccgggaac agcaccggtt catcagcttc cgccttcagc catttcgaga ttcaatgaaa 919021 taccaatcaa caacacaaaa accgctgata ctgctaatag catcagcaca ttgccgttac 919081 aaaccgagac tgcggaaagc gggtctgatc atcagcttcc ggatacgtca gcgggctact 919141 ataactttat ggtaatcggt gcggcggtga cattgtcagg aacttatcta tatgtcagaa 919201 gaaaaaggag cgcctccaga acgtgaaaaa agttattcca ctattcatca ttgctgccgg 919261 cctagtgatc gcaggctatg gaggctttaa attgatcgat acgaatacga aaacggaaca 919321 gacattaaaa gaagcaaagc tggcggctaa aaagccgcag gaagcttcgg ggacgaaaaa 919381 tagcacagat caagcaaaga acaaagcatc atttaagcct gagaccggcc aagcgagcgg 919441 cattttagaa ataccgaaaa tcaatgcaga gcttccgatc gtggagggca ccgatgctga 919501 tgatttagaa aaaggtgtcg ggcattacaa ggacagctat tatcctgatg aaaacggaca 919561 aattgtgctg tcagggcatc gggataccgt gtttcgccgg acgggagagc tggaaaaggg 919621 ggatcagctc cgtcttctcc tgtcatatgg agaattcaca tatgaaattg taaaaacaaa 919681 aattgtcgat aaggatgaca catctattat cacgctccag catgaaaagg aagagctgat 919741 tctgacgacc tgctatccgt tttcatacgt cggaaatgcc ccgaagcgct atattatata 919801 tggaaaacga gtgacttaaa aagccgaggc agtgcctgcg gcttttcttc atgaaaaata 919861 tgtgcggcaa aggtttttca tatcagcagg gaaaggggct tcagcaacta tgagctcgtc 919921 tgttatcggg tgaaccgctt gtactttatt ggcgtgcagt gcctgcctgt ttagcagctt 919981 gctcccgcct ccgtaaagcg agtctcctgt caacggatgg ccgaggctcg ccagatgaac 920041 acggatttgg tgtgttctgc ctgtttccag ctctaattca acgagcgaca gccgttcttt 920101 cgcattgctg gccattacct tgaaatgagt gacggctgtt tgcccgcctg gtgaaacccg 920161 gcgtcttgtc gggtgtgagc ggtctctgcc gatcggtgaa ttaattgtcc cttttttcgt 920221 ccgtagctta ccttcagcga tagcggtata cgtacgcttc agcgtctttt tctctaactg 920281 ctggtctaag atggcgtgtg ccaaacgatg cttggcaaaa acgatagcgc cagatgtatc 920341 ctgatcaaga cgatggacgt ggcgcacctt acatgtttcg ccatttatct gataatgata 920401 cgcgatcaaa ttagccagtg tgccggtttg cccatcctca ttcggatgcg tcgcgatgcc 920461 agcgggttta ttgatgatga gcatatgatt gtcctcaaat aaaatatcaa gctcgccata 920521 ctccggaatg accgaagatg cttcactttc ctgaagatca atgaacacgc ggtctccctt 920581 ttttacaatc atattgttta agacggattc gtgattgacc tttatctgtt gatgggacat 920641 ccagtcttgt atcactggtt tagaagcttt gagcgctgtt ttgagtacgg aaaacagcca 920701 ttggccgtcc tgtttttcat tgatgaggat ctcaagccct ctgccttttt ggttcatgtt 920761 aaatggctcc ttttcgaagc ggaaggctgc tgtttctcat aggaaacact taccttagct 920821 ttcgcgtttt tttctgtgct attcttgagt aagacttagg atattcgatg gcaagaaagg 920881 tgattgacgt gagaattgtg aacgcagcaa ctgcagaaca ggagagcttt atcaaggagc 920941 tgtctatgga gctgatccat gatgtatttc ctctttattt ctccgaactg gacattcagc 921001 gctttaaaaa gaaaggcgtt ctgtctttaa ataaccatta ttaccaagga acattaaaag 921061 aagcatttca aattatggct tgtctgcaaa tgatacatat tatcctgacc aagccttcgc 921121 cgcactctga tttgagtgat caggcgattt ttgaaaaaaa cagcaagatg ctgaatgatt 921181 ttgggattta ttttccgttt gctttttctg actttcaaaa gaagactaac aaagcctttt 921241 tcggtcaaag aaggctgata taatcatgcg gcaagggctt ttctattttt agaaaagctc 921301 tttttgtatc agagaaatca tatcataaaa cctttcctct aactcccttt ttaaacggct 921361 cgtgtctgaa catactaatg attgaaaggg gtgctgacaa tgagttcagt taaagataca 921421 atgacaacgc aggtggcaac cgtttctccg aatcaaacga ttcaggaagc ggcttctcta 921481 atgaaacagc ataacgtcgg ggcgatcccc gttgtagagc aaggtgtttt aaaaggaatg 921541 ctgactgacc gtgacattgc attaagaact acagctcagg gccgtgatgg ccagacaccc 921601 gtttcagaag tgatgtcaac agaactcgta tcaggaaacc ctaatatgag tctggaagac 921661 gcgtcgcagc tgatggccca gcaccaaatc cgccgccttc ctattgtaga tcaaaacaat 921721 ctagtcggga tcgttgcgct tggagacctg gcagtcaatc agatgtcgaa cgagtctgcg 921781 ggatcagcgc tgacaaacat ttctcaccaa aacattcatt aataagaaag agcttgcagt 921841 gtgcaggctc tttcttcaca taaaacctta ctttttgaaa gcagacttgt ttcggggtat 921901 agtgagtgta tacatatgtc tcaattcgta ctaaaggagt tgtacccagt gattaaagcg 921961 ttaatttttg attttgacgg gcttattcta gatacagaaa cacacgaata tgaggttctt 922021 caggaaatat ttgaagagca cggctcagtg ctgccgctat ctgtctgggg aaaggtcatc 922081 ggaactgctg cgggtttccg gccttttgaa tatttagaag agcagatcgg gaaaaagctg 922141 aaccatgaag agctcacaca attgagaaga gagcggtttg ccaaacgcat ggaatcagaa 922201 aaagcgagac ctggtgtcga agcgtatttg aatgcggcaa aggatttagg cttaaaaata 922261 ggccttgcct ccagctctga ttataaatgg gtgtccggcc atttgaagca aatcggcctg 922321 tttgatgatt ttgaagttat tcaaacggcg gatgatgtgg aagaggtgaa gccgaatcct 922381 gaactctatt tattggcggc aaagaacctg ggggtatcgc cagcggaatg tctcgcgttt 922441 gaggattctg tcaatggttc gattgctgcg aaacgtgcag gcatgaagtg tgtcattgtc 922501 ccgaataaag taacgggtac cttgatgttt gaagactatg atcacaggct tgaatcaatg 922561 gcggagatgg agctcgccct attgcttgat catctgaact cacaaaacta gaaaggagcg 922621 agtaggttgt ctgagaaatt agatttgacc cggtttgaaa agaaaatggt tatccgcaat 922681 atcgaagaga aagacatcga caagattatc gatcttcaaa aggactgctt tccaggaatg 922741 gagccttgga agcgggagca tttaatcagc catttggagc attttccgga aggacagttt 922801 tgtgcagaat tcgaaggtga aattatcggt tcgtgctcaa gtctcctgat taactttgat 922861 gaatatgatg accgccatac gtggcaggac attacagatg acggttatat caccaaccat 922921 aatcctgacg gcttgaatat gtacggaatt gaagtcatgg tgcacccgaa atacagacga 922981 atgaagatcg gccaccgttt gtacgaggcg agaaaggact tagccagacg cttaaacctg 923041 aaaagcatca tcataggcgg acggattcca aactatcaca aatatgcaga ggaaatgaca 923101 gcgagagagt atgttgaaca ggtgacacgc caccaaattt acgatccggt tctttctttt 923161 cagctgatga acggctttac ccttatgcga attaacccga actatctccc ggatgataca 923221 gcttcgatca agtatgcgac gctgatggaa tggaataatg tcgattatct accgcagcag 923281 acaaaacgct attataaatc ggcgttccct gttagaattt gtgtgatcca atacgaaatg 923341 aagaaaattt attcctttga ggaatttgcg aatcaagtag aatactatgt cgatgttgct 923401 tccgacgcaa gatctgattt tgcggtgttc ccggaaattt tcacaaccca gctgatgtcc 923461 ttccttgagg aacggtcacc gagcttggcg gtgcagagaa ttaccgagta tacagaagat 923521 tacatcagcc tgtttactga cttggctgtg aagtataacg tcaacattat cggcggatct 923581 catttcgtcg aagaggaagg caagatctat aatatcgctt acctgttcag acgggacgga 923641 acgatcgaga agcaatacaa actccatatt acgccgaatg aacgcaaatg gtgggggatc 923701 agcgcaggag accaagttcg cgtgtttgat acggactgcg ggaaaatcgc gatccagatc 923761 tgttatgaca ttgaatttcc tgagcttgcc cggattgcgg ctgataaagg agccaaaatc 923821 atctttacgc cattttgtac agaagaccgt caaggctatc tgcgtgtcag atactgttcg 923881 caggctagag cggttgaaaa tcaaatttat acggttatct ctggaacggt cggaaacctt 923941 ccgcaaacgg aaaacatgga tatccaatac gcccagtcag gcatctttgc cccgtctgat 924001 tttgaattcg cccgagacgg cattgtcggc gaaacaaacc cgaatattga aatggtcgtc 924061 atcggcgatg ttgacctgga aattctcaga agacagcgcc aaaacggtac agtgcgccag 924121 ctaaaagaca gacgacgtga tatttatcat attcaatata aaaaataatt cccaaaaaac 924181 ccgcctgaat tggcgggttt ttttaaacaa aagcggaatt gtttaggtgc tttctttaaa 924241 ataaaagtaa attgtatagt ggatgtgcct tatggagttt ctgtattttc gccatttcct 924301 atatcataca gaaaacggct aggcttcaca ttgctattgc aatggctgtc caagttgttt 924361 cgagtgcgac ctttatcagt acgatgctga gcattgtcac tttgcctgtt ttgctttgga 924421 agctgcatcc tctttcttct tgagaaaggg gatgttttat tatttacgcg gtttattgac 924481 tctgacccgg tctggcttta tattgaaggc agggaaatca tcaccaagac atcacataaa 924541 gagaaggtct gtttcaattg aattggcatt atagggaacg ctaatgaaat ggagatgatg 924601 gggatggaaa acattcagca aaatcaggga ttaaagcaaa aagatgagca atttgtgtgg 924661 catgccatga agggagcgca tcaagcggac agcctgatag cccagaaggc cgaaggggcc 924721 tgggtaaccg acacagacgg acgccgctat ttggatgcga tgtccggttt gtggtgcgtc 924781 aacattggtt acggcagaaa ggagcttgcg gaggctgcct atgagcaact aaaggagctg 924841 ccttactacc cgttaacgca aagtcacgca cccgcaattc aactggcgga aaagctgaat 924901 gaatggcttg gcggcgatta tgttattttt ttttccaaca gcggatcgga agcaaacgaa 924961 actgctttta aaattgcccg ccagtaccat ctgcaaaacg gcgaccacag ccgttataaa 925021 ttcatctcaa gatatcgggc ataccacggc aatacattgg gagcgctctc agctaccgga 925081 caggcgcagc ggaaatataa atacgagcct ttgagccaag ggttcctgca tgcagctccg 925141 ccagatatat accggaatcc tgatgatgca gacacgcttg aaagcgcaaa tgaaatcgac 925201 cgcatcatga catgggaatt aagcgaaacg attgccgggg tcattatgga gcccatcatt 925261 acaggcggag gcatcctaat gccgccggac ggatatatga agaaggtgga ggacatttgc 925321 cggcgccacg gagccctttt gatttgcgat gaagtgatct gcgggtttgg acggacaggt 925381 gagccgttcg ggtttatgca ctacggtgtg aagcctgata tcattacgat ggcaaaggga 925441 atcacaagcg cgtatctgcc attgtcagcg actgctgtga aacgggacat tttcgaagcg 925501 tatcaggggg aagctcctta tgaccgtttc cgccacgtga acacgttcgg cggaagcccg 925561 gctgcctgtg ctttggcgtt gaaaaacctg caaattatgg aggacgaaca gctgattcag 925621 cgatcccgtg atcttggagc aaagctttta ggtgagcttc aagctctgag agaacacccg 925681 gcagtcgggg atgttagagg aaaagggctg ctgatcggaa tcgaactcgt caaagacaaa 925741 ttgactaaag agccggctga tgccgccaaa gtaaaccaag tggttgcggc gtgcaaagaa 925801 aaagggctga tcatcggcaa aaacggcgat acagtcgccg gctacaacaa tgtcatccag 925861 cttgcgccgc cattttgcct gacagaagag gacctttcct ttatcgtgaa aacggtgaaa 925921 gaaagctttc aaacgatata atataaaagt gaattattaa aggagcacat gatgagtttt 925981 cacaaccagc cgatcttacc ggctattcgc aatatgaagc aatttgatga gtttttgaac 926041 agttcattct cttacggtgt tattcttgat attcatctcg gccagctgaa gggcgtgatc 926101 aaagaagcgc aaaagcacgg aaagaacatg atggtgcacg tcgatctcat tcaagggatt 926161 aagcatgacg aatacggtgc ggaatttata tgtcaggata tcaagcccgc tgggattatt 926221 tccacaagat cgaatgtgat tgccaaagcg aagcagaaga aaatttatgc cattcagcgc 926281 ctgtttttgc ttgatacaag cgcgatggag aaaagcatgg agtttatcgg caagcataag 926341 cctgacttca tcgaagtgct tcccggcatc gttccgtcac tcattcagga aataaaagag 926401 aaaacaggga ttcccatctt tgccgggggt ttcatccgta cggaagagga tgtagagcag 926461 gcattgaaag cgggggctgt agctgtcaca acatctaata ccaaattgtg gaaaaaatat 926521 gaaaactttt tgacggaaag tgattgacac cgctttcatg cactgataca attgcactag 926581 gttaatacat tgtgatggag aactcggaga ccacagcagc tctttacggc aaatgtttat 926641 gcacccgtaa agcggtttgt tgtggttttt ttattctctt cttctctatc atgcttttta 926701 atcgtgactt taggaggaat gtgctatgac agcattttgg ggagaagtca tcggtacgat 926761 gctgcttatc atttttggtg caggtgtttg tgcaggtgtc aatttaaaga aatcgctttc 926821 attccagtct ggctggattg ttgttgtatt tggatgggga ttgggtgttg ccatggcggc 926881 atacgcggtt ggcggcatca gcggtgccca tttgaatccg gcgctaacga tagcgcttgc 926941 atttgtagga gattttcctt ggaaagaggt tccggtttat attgcggcgc aaatgatcgg 927001 agcgatcatc ggtgcggtga ttatttatct gcattacctc ccgcactgga agtcaacgga 927061 tgatcccgct gccaagctgg gtgttttctc aacagggccc agcattccgc atacatttgc 927121 aaacgtttta agcgaagtga ttgggacatt tgtccttgta cttggaatct tggccatagg 927181 tgcaaatcaa tttacagaag gacttaatcc tttaatcgtc ggtttcctca ttgtagcaat 927241 cggtatttct ctgggaggca ccaccggcta tgctatcaat cctgcacgtg acttaggtcc 927301 gcggatcgcc cacgcttttc ttccgattcc ggggaagggc tcatcaaact ggaaatacgc 927361 atgggttccg gtagtcggcc cgattttagg cggatcattc ggcggtgtat tttacaacgc 927421 tgcatttaaa gggcacatca caagcagctt ctggattgta agcgttatat tggttgtggt 927481 attgttagga ctctatgttt atacgaaatc acattctgct aaaacattat caaattctaa 927541 atatatttaa tcaaagggga gacatcttat ggaaacgtac attttatcct tagatcaggg 927601 gacgacaagt tcaagagcga ttctgtttaa taaagaaggc aaaattgtcc actctgctca 927661 aaaggaattt acacaatact tcccgcatcc tggctgggtt gagcataatg ccaatgaaat 927721 ttggggctct gtcctcgcgg ttatcgcctc agtcatctct gaatcaggaa tcagcgcttc 927781 tcaaattgcc ggcatcggca tcacgaacca gcgcgagacg acggttgtgt gggataaaga 927841 tacaggaagt cctgtctata atgcaatcgt ttggcagtcc agacagacgt ccggcatttg 927901 tgaggaactt cgtgaaaaag gatataatga taaattcaga gaaaaaacag ggcttttaat 927961 cgatccttac ttctccggca cgaaggtgaa gtggatttta gacaatgtgg aaggcgcaag 928021 agaaaaagcg gaaaaaggcg agctgctgtt tggaacgatt gatacgtggc tcatttggaa 928081 aatgtcaggc ggaaaagcgc atgtgaccga ttactccaat gcctcaagaa cactgatgtt 928141 taatatttac gatttaaaat gggacgatga actgctcgac attctaggcg taccgaaatc 928201 catgctccct gaagtgaagc cgtcctctca tgtgtatgcg gagactgttg attatcactt 928261 cttcggaaaa aatatcccga ttgctggagc ggcaggcgac cagcagtccg cattgttcgg 928321 ccaggcatgc tttgaagaag gcatggggaa aaacacttac ggcacaggat gtttcatgct 928381 gatgaatacc ggggaaaaag caattaagtc cgaacatggg cttttgacaa caatcgcttg 928441 gggcattgac ggaaaagtga actatgcgtt agaagggagc atttttgtcg caggctctgc 928501 catccagtgg cttagagacg gtttgagaat gttccaggat tcatcgctaa gcgaatctta 928561 tgcagaaaaa gtggattcaa ctgacggcgt gtatgttgtt ccagcatttg tcggactggg 928621 aacgccttac tgggacagcg atgtgcgcgg ttcggttttc ggcctgacaa gagggacaac 928681 aaaagagcac tttatccgtg cgacactgga gtcattggct tatcagacca aagatgtgct 928741 tgacgcaatg gaagcagatt caaacatttc attaaagacg ctccgtgtag acggaggagc 928801 tgtaaaaaac aatttcctaa tgcagttcca aggagacctg ttgaatgttc ctgtggagcg 928861 cccggaaatt aatgaaacga ctgcacttgg cgcggcttat ttggcgggta tcgctgtggg 928921 attctggaag gaccgttctg aaatcgcgaa ccagtggaat ctggataaac ggtttgagcc 928981 tgaattggaa gaagaaaaac gaaatgagct gtataaaggc tggcaaaaag ccgtgaaagc 929041 agctatggct tttaaataaa gtaatactat ggtataatgg ttacaagtta ataagaacgg 929101 tcctgagatg aggagagacc acagcaccaa agtgtaagca tgcactttgg ctgttgtggt 929161 ctctttttct atttaccgtg acaacaagga ggaaacgtaa tgatgaatca tcaattttca 929221 agtcttgaaa gagatcgcat gctgacagac atgacgaaaa aaacatatga cctatttatt 929281 atcggaggag gaattacagg agccggaaca gctcttgacg cggcatcaag gggaatgaag 929341 gtcgcactaa gcgaaatgca ggactttgcg gcgggaacat caagccgatc aacgaagctg 929401 gtacatggcg gcttgcgcta tttaaaacaa tttgaagtga aaatggtcgc tgaggtagga 929461 aaagagcggg cgattgtgta tgaaaacggc ccgcatgtca ctacaccgga atggatgctg 929521 cttccgtttc ataaaggcgg cacattcggt tcatttacaa catctattgg gttaagggtt 929581 tatgacttcc ttgcaggtgt gaaaaagtca gaacgaagaa gcatgctttc agcaaaagaa 929641 acgctgcaaa aagagccttt ggtgaaaaaa gacggcttaa aaggcggcgg gtactatgtg 929701 gaataccgca ctgacgatgc gagactgacc atcgaagtca tgaaggaagc ggttaaattc 929761 ggggcagagc ctgtgaatta ctccaaagtg aaggagcttc tttacgaaaa aggcaaagcc 929821 gtcggcgtat taattgaaga tgtgctgaca aagaaagaat ataaagtgta tgcgaaaaaa 929881 attgtcaatg ctacaggccc ttgggtcgat cagctcagag aaaaagacca ttcgaaaaac 929941 ggaaagcatt tgcagcatac aaaaggcatt caccttgtat ttgaccagtc tgtctttccg 930001 ctgaaacagg ctgtatattt cgatacacct gatggccgga tggtatttgc gattcctcgt 930061 gaaggcaaaa catacgtggg aacaacagac actgtttaca aagaggcgct ggagcatccg 930121 cggatgacaa cggaggatcg tgattatgtc atcaaatcaa tcaattacat gttcccggaa 930181 ctgaatatca ctgcgaatga catcgaatcc agctgggcgg ggctgcgtcc gctgattcat 930241 gaagaaggca aagatccttc tgaaatttca cggaaagacg agatttggac atctgactca 930301 ggcctgatca ccattgccgg cggaaaactg actggataca gaaaaatggc ggagcacatc 930361 gttgatcttg tccgtgatcg cttaaaagaa gagggcgaaa aggattttgg accatgtaaa 930421 acgaaaaaca tgccaatctc tggcgggcac gtcggcggtt cgaaaaatct tatgtccttc 930481 gttaccgcga aaacaaaaga aggaattgca gccggtttat cagaaaaaga cgcaaaacag 930541 cttgcgatca gatacggctc taacgtagat cgcgtctttg accgggtaga agcgctgaaa 930601 gatgaggccg cgaaacgcaa cattccggtt catattcttg ctgaggcaga atacagtata 930661 gaagaagaga tgactgcaac ccctgctgac ttctttgtcc gcagaacggg acgtttattt 930721 tttgatatca attgggtaag aacatataaa gatgccgtta ttgattttat gagcgagcga 930781 ttccaatggg atgagcaggc gaaaaacaaa catacagaaa acctcaacaa gcttttacac 930841 gatgcggtcg taccgcttga gcaataaatc ataacgggct gtctgcagcc cgttatttct 930901 ttttacgtgc cgaaaggggg agatctcagg ttatcaagtg acagaggcac ccgcttcata 930961 taaaataatg gcataagctg atacatagga ggacgaatat gacttggaga aagagctatg 931021 aacgctggaa acagacagaa catttagatc tggaattaaa agagcgcctt attgaattag 931081 agggagatga acaggccctt gaggactgtt tctataaaga ccttgaattc ggtaccggcg 931141 gaatgcgcgg ggaaatcggc gccgggacaa atcggatgaa tatttacact gtgcgcaaag 931201 catcggccgg gtttgcggca tacatctcga agcaaggtga ggaagcgaaa aaacggggcg 931261 ttgtcattgc ttatgattcc cgccataagt ctccggagtt cgcgatggaa gcggcaaaaa 931321 cacttgcgac acaaggcatc caaacatacg tgtttgatga gcttcgcccg acgccagagc 931381 tgtcattcgc tgttagacag ctgaacgctt atggtggaat tgtggtaacg gcaagccata 931441 acccgcctga atataacggc tacaaagtat acggggatga tggcggccag ctgcctccaa 931501 aggaagcgga catcgtcatt gagcaggtaa acgcgattga aaatgagctg acgatcacag 931561 tggacgaaga aaataagtta aaagaaaaag gcttaatcaa aatcatcggt gaagatattg 931621 ataaagttta tacagaaaaa ctgacgtcca tttctgtaca tcctgaatta tcggaagaag 931681 tagatgtaaa ggttgttttc acaccgctgc atggaactgc aaataaaccg gtcagacgcg 931741 gtcttgaagc actcggctac aaaaatgtaa cggttgtcaa agaacaggaa ctgccggatt 931801 caaacttctc cactgttaca tcgccgaacc cggaagagca tgcggcattc gaatatgcca 931861 ttaagcttgg ggaggagcag aatgcagata ttctcatcgc gacagatcct gatgctgacc 931921 gcctcggcat cgcggtgaaa aacgatcaag gcaaatatac agtgctgaca ggaaaccaaa 931981 ccggagcgtt gctgcttcat tacctgcttt ctgaaaagaa aaaacaaggc atcctgcctg 932041 ataacggtgt tgttctcaaa acgatcgtca caagcgaaat cggccgtgct gtagcttctt 932101 cattcggcct tgatacgatt gatacgctga caggctttaa gtttatcggt gaaaagatta 932161 aggaatacga agcatcaggc cagtatacct tccaattcgg ttatgaagag agctacggtt 932221 atttaatcgg ggattttgcc cgcgataagg acgccattca ggctgcgctt ttggcagttg 932281 aagtttgcgc gttctataaa aaacagggaa tgtcattgta tgaggcgctc atcaatctct 932341 ttaacgaata tggtttttat cgtgaagggc tgaaatccct gacgctgaaa ggcaaacaag 932401 gagcagagca aattgaagcg attcttgctt ccttcagaca aaatccgccg cagaaaatgg 932461 cgggcaaaca ggttgtcaca gcagaagatt acgctgtaag caaacggacg cttctgactg 932521 aaagcaaaga agaagccatc gacttgccaa aatcaaatgt attgaaatac ttcctggaag 932581 acgggtcttg gttctgtctc cgtccttctg gaactgagcc gaaggttaaa ttttatttcg 932641 ccgtaaaagg gtcatctttg gaagacagtg aaaagcgact tgccgtcctt tctgaagatg 932701 taatgaagac ggtggatgaa attgttgagt caacagcaaa ataattcaag tatgagctgg 932761 gtcattgtaa atgatccggc tttttctttt tctcatccaa aagtctgaaa gaaaatcatc 932821 ctacaagtga agcaatgaaa tacaaaaaac tggtataatc ttaaatacaa gatcaatgcc 932881 ggagtgagaa acgtgagcaa aacgaggatg gaaaaattaa aaacgctgaa aacgattgcg 932941 gaaaccttaa atcaagggca cgatatcaaa gcaacactgg atgaggtttt aaaagagttg 933001 ctgagtctga caaaccttca atccggatgg atttttctga tcgaagaaga tgggtcttat 933061 acgttagcgg ccgacgctta tctgcccccg gctttaagcc gcaaggaaaa agtgctgatg 933121 tgcgaagggg agtgttactg cctgacgaaa ttcaataacg gagggcttag aaaagctgca 933181 aatatcatga actgcaaacg catcgaatca gcagaaaacc tgcattgttt tgacacagaa 933241 gggattacgc atcatgcaac tgtgccttta gaagacgggg acagaagatt cggattgtta 933301 aatgtagcgg cggccggaaa aaccatgttt gatgaggaag agctgcattt actcgagtct 933361 gtcgcctttc agatcggaac ggcaatccag cgtatgaggc tttctgaata tcaacaaaaa 933421 aatgctcttt taatggagcg taaccgcctc gctcaggagc ttcacgattc agtcaatcaa 933481 atgctgtttt ccgtcagttt aactgccaaa gctgcgaaga cactaacaaa agatgaaaat 933541 ttacagcaga tgattgattt catccaaaac ctatcacagg acgcgctcgc agaaatgaaa 933601 gcgttaattt ggcagcttcg ccccggagga ttggaaaaag ggctggctga agccattaaa 933661 agctatggtg cgctcattgg attgaagatc atttttacac aaaaaggctg tcctgttctg 933721 actgatgagc aggagcatat gctatggcgt gtcgtacagg aagctttaaa taactgcaaa 933781 aagcatgccg gaacggatac ggcgtatgtt agtctgactg cttctttgtg ccatgcggag 933841 ctggatatca tcgatcatgg ggcaggattt cgctatgaag cgcatgccgg tctgccttca 933901 cttggcataa aaggtatgaa agagcgagcg gaaaaagccg gagctaagtt ttggattgag 933961 tcagcgcttg gaactggaac aaagctgtcc atcaggcttc cgctaaaaag ccgaaaagga 934021 ggggcggtat gaaaattgtc attgctgatg atcatcatgt tgtcagaaag ggtctgcgtt 934081 ttttctttgc cacccaggat gatattgaag tcgtcggaga agctgcaact ggattagaag 934141 ccctccgtgt catcgaagag acaaagccgg atcttgtgct aatggatttg tctatgcccg 934201 agatggacgg cattcaagcc attaaaaaag caatacagca atttccggat acgaatatca 934261 ttgtgctgac gagctactct gatcaggagc acgtcatccc cgcgcttcag gcaggcgcga 934321 aggcgtatca attaaaggat acggagcccg aggaattggt gaaaacacga caagtgcatg 934381 gtggcgaata caagctttct acagctatta tgccccatgt gctgacacat atgaaaaatc 934441 agcacgaccc ggaaaaagaa aaatactatc aattaactag aagggaaaaa gacgttctga 934501 ctgaaatagc gaacgggaaa agcaataaag aaatcgcagc agccttgttt atttcagaaa 934561 aaacagtaaa aacccatgta tcgaatcttt tagcaaaact tgaagtggcc gatcgcacgc 934621 aagcagcgct tttcgcagtg aaatataacc tgaatggaga gatctcaaaa tgaacatgtt 934681 agtcataaat ggcacgccaa gaaaacatgg cagaacaaga attgcagcat cctatattgc 934741 agctctgtat cacacggatt tgattgatct aagcgagttt gtattgcccg tttttaacgg 934801 tgaagcggaa caatctgaac tgttgaaagt acaggagctt aagcaacgcg ttacgaaagc 934861 ggatgcgatt gtattattat cgcctgaata tcacagcggc atgagcggcg ctttaaaaaa 934921 tgccttggat tttctaagca gcgaacaatt caaatataag cccgttgcat tattggcagt 934981 agcgggaggc ggaaaaggcg gcatcaatgc gctgaacaat atgagaactg tgatgcgggg 935041 tgtctacgcc aatgtcattc cgaagcagct ggtgcttgat ccggtgcata ttgatgttga 935101 aaatgctaca gtggctgaaa acattaagga aagcataaaa gagcttgtcg aagaactcag 935161 catgttcgca aaagcaggaa atcccggcgt ctaaacgccg ggatttgttt atgtgagaag 935221 ggctatttga tcttcataag tcagctctgt ggcatgatca atatatcgga gaagggaata 935281 cagcatcttt tctaaaacgg cgtaatcctg ttcaaaatga tacgcatgca gaaaatgctc 935341 aattcgtttt gataacaaat cgtcctctgt acgcaccatt aaaattaata aattatccca 935401 ttgagaacga tgggtgtaat aaagcgcttt atcgtaatcg gcataatcca tgaatcgctt 935461 ctcctttctt gggtgagaag ttcatgatta gtttatgccg catcctctgt tattgacggg 935521 gcaaaacttg ccgtctgcgt cagtaaaggg gtagcaatat gagggagaca taaaatcaaa 935581 atgcctgaat gaagatatcg cttttggtaa acctatgagg gaatatattc tgggtacagg 935641 agactgaaaa aatgaaatcc ctgccgtata ccatcgcact tcttttttgc ggattgatta 935701 tcgtgtcaat ggctgcaaaa ggtcattcaa cggacacaga cgagtccgtt caaaagtggg 935761 aacagcttgc ctggagcaaa attcaggatg aatataaggg cgcttcattt tctgattatg 935821 cttatatggg gcgtacagag gtgaatgatc agcagactaa agatgtcttt cgggtgacag 935881 tcagacagaa agatgacact ttttctgttc gggccgaagt ctattttcat ccggtgacaa 935941 atcatatgat cagcatcaac gtctttaggc tctaataaaa aactgtacag ccgttaaggc 936001 cgcacagttt ctgtttttag aaatatcgtt ttgcaccgag atagcgctgt ttccagtaag 936061 agttgttcat attggaaatg acaactccgg aatcgttggc atttatgaat tccccgttgc 936121 ctaggtaaat tccgacgtgg gaagggccgg ctttatatgt tgaaaagaaa acgaaatctc 936181 cgacagcagg ctggctaact gatttcattg tgttccaata tcccgctgcc gttaatctag 936241 atacggatgt gactttgttc agtacatagt aaatgaatcc gctgcagtca aacccggacg 936301 gtgtcgtgcc tccccagcga tacggaaccc caagctgcgc tttagcggcc gaaatcattg 936361 tgttaatctt cgcactcgtt gagctggtgg tgtttgaaga accggatgaa gacgatgatg 936421 aagcttttcc ggaaatgacc agcttttggc caacctgcaa gacatccgtt tttaaattgt 936481 ttttctcacg aatctgctga gctgttacat taaatttttg agcaatcacc cataaggaat 936541 caccgctttt caccgtgtat gtagtcgtcg tgccggagct tgcatttgac gaagaagacg 936601 acgatgatga agagcctgaa gatgctttac ctgtcagctt caatacttgt ccaacgtaaa 936661 gcacatctga tttcagattg ttgatatttc ggatttgctg tacagtcagg ttatagttgt 936721 ttgcgatttt ccaaagtgaa tcaccgcttt taacggtata tttagttgtt gctgaagttt 936781 ggttcgattt ggatgaattg tctttagaag acgtatcaga gccgcttgat tttgttttca 936841 acacctgatt cacgtaaatg gtgtctgatt ttaagttgtt caagaccttc aattcagcga 936901 tggacatatt gactttgttt gcaattttcc aaagtgaatc tccaagctgc accttatatg 936961 ttcccgtaga agatgaagaa cttgaactct tattagaact gctttttgaa ctggagcttg 937021 aactcttatt agagttgctt tttttactgg aactagagct tgaagaaaca gtaccggaca 937081 cctttaattt ctgcccagca cgaattaaat cgctgcttag tccgtttaat tttttcagtt 937141 cctgcaccgt cattttaaac tcatttgcga tcagccaaag tgaatctccg cttttcactg 937201 tgtaaacaga acttccgctc ttcttggttg ttgagcttga agtagatgaa gaagtgctgg 937261 atttgctgcc tggaatagta agcgtctggc cgatcgacag aacagtagtc gaaagatgat 937321 tggcggatgt gagggccgcc acacttgtgt tataggtttg ggccagtttc cataaagaat 937381 ctccgctttt gaccttaatc gttgctgctt cagctggtgt cactactaaa gttgtgccga 937441 caatcgcaga tgctgtcagc cctgctgcta atttcttttt catcttagct ctcctttttc 937501 ccccaatgat tttgcatttg ctgtttcttt tttatatcgg cacatttgtc tcatcgtttt 937561 gcctttttat aaaaatagcc aaattatctt aacaataagg gggaaaaagg gcataaaaaa 937621 agaaggaatc ttaatctatt ccttcatttt taaaagcttc atgatatctt ctttgttttt 937681 gacgaggtcg cgcagtgtgt atttgtctaa aactgcgagg taggctaaaa gcgcttcatt 937741 cagcacatgt tttaagccgc aaaccgggga aataacacag agattcttgt tcgcatcaaa 937801 acattcaaca atattaaaat cgtcctccgt ttttctgaca acctcaccga tgttgatgtc 937861 ttcagggtcc atgcctaatc gtatgccgcc gccccgtccg cgtatcgttt ctacgtagcc 937921 gagctggccg agcctgtata tgactttcat gagatgattt tttgaaatag aatacgtttc 937981 ggcaatctgt tttatatttg aaagttctcc gggacgctct gcagccagaa aaatcaacac 938041 tcttaatgaa taatctgtat aattggttaa cttcataata agacctcaga ataagacatt 938101 ttctatatct tatcataatc gattgaaaaa tgaaaaaaaa ggaattaaaa aacatgcacc 938161 cagctgggtg catgtttttt gcttacatgt cattcggcgg attttggttt ttacggtttt 938221 tttcgatttc tgtgttttgc attttgcgtt caaatgtaga cagataacgt gatgcaaaat 938281 ccttaccgcc aaggccgaag gataaaccaa aagcaagtgc gaagccgcta agaacgatga 938341 tgaacgcgga attgacgatt gtcgcagcga cacccagctg atccagggcc ataaagaaag 938401 caagtgcgat aatcgtatat ttagcaatag gcgctaaaga cttgaattcc tgacctttta 938461 tcatgcttgc gagcactttt ctcaccaatt ctcctgcgta aaggccgagt ccgagaatga 938521 atactgcgac aaggacattc ggcagatacg cgatgatgcc ggtggcaatt tctacgagga 938581 agtgcagccg aacaatttga agcgcctcag ctgtaaagag cagaatgaca atgatttgcg 938641 caatcatacc gacaacttga gacaaggaca gctttgcagg cgttccggct tccatgccca 938701 ttttccctaa gacagaatca aagcctgcgc gatggagcag tccggacacc atggatttca 938761 cccattttcc tgcccagata cccgctaata caagcacgat ggcaatcatg atgttcggaa 938821 gcatgtttaa aatcgtattc agcatagaga cagctggttt tgaaatgccg gcgacatcca 938881 gctgatcaag cgctgaaatg accaccggaa tcataatgag cacataagcg attgttccga 938941 tgactgctga aaggcttgtg tcttttaagt aaattgataa acccatacgt gccgcgaatc 939001 tttcggtgcc gatgcttgca aggaaattcg taatgatatc acggacaagg cgggcaacaa 939061 gccatccgat taatacgata agcgccgctg caaataattt cggcagaaaa gcgagcacgc 939121 tttccatcat atttgtaaaa ggacctgaaa tgccgctgat tttcaaagaa gataagaccc 939181 ctggcagaaa aacaagcagc acgagataaa agacaatttg tgaagcggta ttgacagcct 939241 ggtgaatatc ttttccttca gacaccaaat tccacttgcg cagtttgtca ctcgtgttca 939301 gcttcatccc gatttttttg acaaggaagc tcaaaacaga agctgcagcc catcctaaca 939361 gcagaatgag tccggctttc agcacgcttg ggatcgcagc tgcaatcgcc gaaagcatac 939421 tgacaaacgg cgatgccact gttgtcaggt gcaaaatgtt aaagaataaa ataaagacga 939481 tgatcagtgc gataaaataa acgaccttgc ttatgacttt ttccgaggaa tagcgtgaag 939541 gctttttccc agcaaagagc ttgtcgtcga tttttgtttt gctgagtcct ttgtataccg 939601 ctttttcaat gattttagca atagcccagc cgattaataa gacgagtaaa gcaatgatta 939661 cgtttggcag cttactgaga taagaagaaa acacgtctgc tacattcaat tggtatcgct 939721 cctttttcgt agtatggtgt gtgtttaccc acttatccaa taagcaaaca gatgaatgtg 939781 ccgggggaat tttttcttgc ccgagtgaga ctatcatctt ttgtctggcg ggctcataca 939841 ttatagataa gtccaagtag gggggattcg gttgaacgcg gaggagaaga agggattaca 939901 gcgggcaatt gaggaaatta ccgaaattgc aaaaggattc ggccttgatt tctacccgat 939961 gagatatgaa atctgcccgg ctgaaattat ttatacattt ggcgcgtacg ggatgccgac 940021 aagattcagc cactggagct tcggcaagca gtttcacaag atgaagctgc actatgatct 940081 agggttaagt aagatctatg agctggtcat taactcagat ccatgctacg cttttttgct 940141 ggacagcaac tcactgatcc aaaataaatt gattgtcgca cacgttcttg ctcattgcga 940201 tttcttcaaa aacaactgcc gtttccaaaa cacgaagcgc gatatggtgg aaagcatggc 940261 ggcaacagct gaacggataa aacactatga acaggttcac gggataaaag aagtcgaatc 940321 ttttttagat gcaatccttt cgattcagga gcatatcgat ccgtcgttgg tccgaccaaa 940381 gctccaatgg agtgtggatg atgaggaaga ggagattgaa gaggcagcca cgccttacga 940441 tgatctatgg tctttagatg aaaagaaacc gaaaaaacaa gtgaaaaaat cgaaaaaacc 940501 gttcccgccg cggcctgaaa aagatatcct gctttttatc gaggagcatt cccgggagct 940561 ggagccatgg cagcgtgata tattaacgat gatgagagag gaaatgcttt atttctggcc 940621 tcagctggaa accaagatta tgaatgaggg ctgggcttcc tattggcacc agagaattat 940681 acgtgagctt gatttaacct ctgatgaagc gatcgagttc gccaagctga atgcaggtgt 940741 cgttcagccg tccaaaacag gcattaatcc ttattattta gggctgaaaa tatttgaaga 940801 cattgaaaag aggtacaaca acccgacgga ggaaatgaag aaaatgggcg tgcagcctga 940861 ctccggccgg gagaaaatgt ttgaggtcag ggagattgaa tccgatatct ctttcatccg 940921 caattattta accaaagaat tagtcatgcg cgaggatctt tatttgtttc aaaaacaggg 940981 ccgagattat aaaatcatcg ataaacagtg gaagtcggtg cgcgaccagc tcgtaagcat 941041 gcgggtaaat ggcggttttc catatttgac agtaaacgac ggcgattata tgaaaaataa 941101 cgaactctat attaagcatt ggtatgaggg catagagttg gatttgaaat atttggagaa 941161 agtgcttcct tatttattcc agctttgggg aagaagcgtg cacattgagt ctgtgcttga 941221 ggataaggaa gtcatgtttt cgtacgacgg aaaaggtgtt caccgcagat atttataaaa 941281 aagaggatgc agcgttctgc atccttttta ttttccagtt tttaaaatct taaatatgat 941341 gtttgcctgg tccgtattgt taatcaatcc gcggaatttt tcttttccgg ggccgtacgc 941401 gtataccggt acttcttcgc cggtatgatc ggtactcgtc catccgctgt tggagcgggt 941461 attaaaaatc ttgatgatgg ctttggaggc ccctttgctt ttgtcagcct gtgcagctgc 941521 ttcaacgctt ttgatttctt cagatgtgac tttcagattg gcatagcggg cgagcacatc 941581 tttaaccggc ttgccttcac tgattttttt ggccatgaat tcaggtgttt tcttagcgga 941641 gagaatcggt tctgcgtgcc aattcttttc cccgtttgcg ccaatggtaa agccgccggt 941701 tgtatggtca gcagttgcaa tcacaagtgt atgtttgtct tttttcgcaa attcaatcgc 941761 ggctttatag gcctgttcaa aatctttaac ctcgctcatg gctcctactg tatcattgtc 941821 atgggccgcc cagtcaatct ggctcccttc gaccatcaag aaaaatcctt ttttattttg 941881 gttcaggcga tcaattgctg aaaccgtcat gtctttgaga gacggtgttt tactgtcacg 941941 gtcgagcgct ttagcaagcc ctccatctgc gaaaagcccg agcacctgct gatctttatt 942001 ttttttcaat gcttgtttag ttgtcacata gctgtagccg gcttgtttga attcctttgt 942061 caagtttctg tccttgcggt taaaataaga ttttccgccg ccgagcagca cgtctatttt 942121 atgtttgcct tttatcttgt catccatata gctgttggcg atttggtcca tgtttttccg 942181 tgattcattg tgggcgccat atgcggctgg agtggcgtgg ttaatttcag acgtggcgac 942241 aagccctgtt gacttgcctt gctgtttggc ctcttcaagt acagatttca ctttttttcc 942301 gtttttatcg acgccaattg cattgttata tgtcttaacg cctgtcgcta atgctgttcc 942361 ggctgctgct gaatctgtaa tattatagtc agggtcatcc ggatgcgtca tcatcatgcc 942421 tgtcaggttc cggtcaaatt ctgttaactt cgggttattc ggtgtgtcac cgttattttt 942481 catggaacgg taggctctta tgtaaggcgt ccccatgccg tcgcctatca tcacaatgac 942541 atttctgatc tcagctttgt cttgtttttt ggcgctggcc ttttctgttt gctgaagctc 942601 agctccggca aagattccag ctgtaaggac agaaacagcg gcgattggca gaagttttga 942661 tttcatattt tgaaacaaac tcattttttt catgcctcct ttaatgtatt ccgtttatca 942721 tgttagggaa actttgttaa atgcggctgt tgatcatgta aacaataagt aaagccttgt 942781 aaggaaatga aaaaacgctt ttcgttatct tgccttattt gatgtaaagc attcattttt 942841 cagaaaaatc tttacctctc tgtctttgca tgatatgttt gtttaaataa aaaaactgcg 942901 gataaccaca gctctcctcg aatatacttt atcactcatt tttccgatat atgagccgac 942961 cccgaaagtt tttcatttat ttcctttatg ttgaaaaaca tcccataaaa catgacaaaa 943021 gcactcgttt tttgtcacct ttgcaatgaa aatgaaatat ttaataccct taaaaacttt 943081 tttttagaac gaataattaa gaaatttgtc acatgaagtc aagactattt ctgatgggaa 943141 tctatcctta taatagaaat caataagatt aatttaaaaa aagagataca tatatataga 943201 gttaacattt ggggaggaaa atatgaaaaa gcaaatcatt acagctacga cagcagttgt 943261 tttaggatcg acgttatttg caggagcggc atctgcacaa agcattaagg tgaaaaaagg 943321 cgacacgtta tgggatcttt caagaaaata cgacacaacg atcagtaaaa ttaaatcaga 943381 gaaccacctt cgttcagaca ttatttatgt gggacaaact ttatcgatta acggcaaatc 943441 tacaagttca aaaagcagca gttcttcttc ctcttcttct acatacaaag taaagagcgg 943501 ggacagcctt tggaaaattt caaaaaaata cggcatgaca atcaatgaac tgaagaagct 943561 gaatggctta aaatcagatt tgcttcgtgt tggacaagtc ctgaaactga aaggttcaac 943621 tagttcaagc agctccagct catcaaaagt gtcatcgtct tcaacttcta cttataaagt 943681 gaagagcgga gacagccttt ctaaaattgc gagcaaatac ggcactacgg ttagcaaatt 943741 aaaaagctta aacggcttaa aatcagatgt aatctatgtc aaccaagtat tgaaggtgaa 943801 aggaacaagc acaagcagct caaaacctgc ttcatcttca tcgtcttcaa gcagcaaaac 943861 gtcatctaca tcacttaatg tgagcaagct ggtttctgat gcaaaagcgt tagtcggaac 943921 gccatataaa tggggcggaa cgacaacttc aggctttgac tgcagcggat tcatttggta 943981 cgtactgaat aaacaaacaa gtgtgggcag aacaagcact gcaggatact ggagttctat 944041 gaagagcatt gccagcccgt ctgttggtga tttcgtcttc ttcacaacat ataaatccgg 944101 cccttctcac atggggattt acattggaaa caacagtttc attcatgcag gatctgacgg 944161 cgtacaaatc agcagcctga acaacagcta ctggaagcct cgttacctcg gtgcgaaaag 944221 attctaattt ttagagaaaa cccgttcatt ggaacgggtt tttttcatta gacggagcac 944281 aggcgttttg gttgctccta aaaatgaaaa tgtgataaaa aatccaagaa ctttttttct 944341 ttcttatttt cataaagggc aatcgcgtaa gcgccggcat agggcagctg tacagactga 944401 taaggaattc tgatcatctg tttctctgct aactcacgct ttactgtaga taaaggcaga 944461 aatgaaactc cgagtccttc cttgataaac cgtttcgtta tatgtgtttg agtgaccttc 944521 attgttctca caaatggaaa tgtcattctg acttgacgga gcaagtcgtc ccagtaatca 944581 ggatgattgt gggtcaaaag caggtattgt tcgagcacct ctttggcatc aatttcgttg 944641 tcttctatga aacgcttatc gggcggggca acaaggacga cagggtcttt gtataagcag 944701 tggcagctta aagaagaaga ctgtaccttt aaacagctta gtccgatatc tgcttccccg 944761 gctttaatca gtgacgcgat ttccgctgat tcgaaaatcg taaccgccat ttctgtttcc 944821 gtattcattg ctgtgtaccg cttcatgaca gaaggaagca ctgtatctgc aataagcgga 944881 gaaaccgcga gctgtaaggt ttgagagtag ccttgtctca ctctgtgaag ctctgccatg 944941 ctgttttcat aatcatcaag aagcctgagc gcatacggca aatacgccct gccttcatca 945001 gtcagctgga tttgcctgcc tttacgctcg aacagcttgc agctgatttc tttttctaat 945061 tgcttgatat gtacggtcac agtaggctga gataagaaaa gcgtttccgc cgtttttcgg 945121 aagttctcat attttgcagc ggtcacaaag gtgtgaagcc atttgaaatc catttctatt 945181 ctccctctga ttaatatttt taattaattc cctttaaaat attgattatt ttttaaatat 945241 tatatttact ataataacag aaaaggatag ggggaataca aatggtacat tacggattaa 945301 agggaattac atgtgtagaa acatccatca gccatattga tggtgaaaaa gggcgtctga 945361 tttacagagg acatcatgca aaagacatcg cactgaatca cagctttgaa gaagcggctt 945421 atttgatttt atttggaaaa ctgccttcaa ctgaagaatt gcaggtattt aaagataagc 945481 tggctgcgga acggaatctt ccggaacata ttgagcgctt gattcaatca ctgccaaaca 945541 acatggacga tatgtcggtg ctgagaacgg ttgtttcagc attgggggaa aatacgtaca 945601 cattccatcc gaaaacagag gaagcaatcc ggctgattgc aatcacgcct tctatcattg 945661 catacagaaa aagatggacg cgcggtgaac aagcaattgc accttcttcc cagtacggac 945721 atgtcgaaaa ctactattat atgctcacag gtgaacagcc ttcagaggca aaaaagaaag 945781 cgcttgaaac ctatatgatt ctggccacgg agcacggcat gaacgcatcg actttttcgg 945841 cacgagtcac gttatctaca gagagtgatt tagtgtcagc cgtcacggct gctctcggta 945901 cgatgaaagg tccgctgcac ggaggtgctc cttctgcggt gacaaaaatg cttgaagaca 945961 ttggagaaaa ggaacatgct gaagcatatc tgaaagaaaa actcgaaaaa ggagagcgct 946021 tgatgggatt cggccacagg gtgtacaaaa caaaagaccc gcgggcagaa gctttgagac 946081 agaaagcaga agaggtggcc ggcaatgacc gtgatcttga tcttgcgctg catgtagaag 946141 cagaagcgat tcgtttgcta gaaatctaca aaccgggacg aaagctgtac acaaatgttg 946201 aattttacgc agctgcagtg atgagggcca tcgattttga cgatgaattg tttactccga 946261 ccttttcagc aagccgaatg gtagggtggt gcgcccatgt actggaacag gcagaaaaca 946321 acatgatttt ccgcccgtca gcgcaatata ccggtgccat tcccgaggaa gttctttcat 946381 aacatatttt ggcgtttatt catttctgtc gtgtggtaac gttcagtatc aaccacatgt 946441 ctaggagtga tgaatgtgaa cccaatggac agacaaacag aaggacaaga accgcagcat 946501 caggacagac agccgggcat tgagtcaaaa atgaatccgc tgccgctgtc agaggacgag 946561 gattatcgag gaagcggaaa actgaaagga aaagttgcga tcattactgg aggcgacagc 946621 ggaataggga gagcagcagc tattgccttt gctaaagagg gggctgatat ctccattcta 946681 tacttagacg agcattcgga cgcagaggaa acacgcaaac ggatcgaaaa ggagaatgtc 946741 cgctgcctgc ttatcccggg agatgttggg gacgagaacc attgtgaaca agctgtgcag 946801 caaacagtgg accattttgg taaactcgat atcttagtga acaacgccgc tgaacagcat 946861 ccccaggaca gcattctcaa tatttcaaca gaacagctgg aaaaaacctt tcgcacaaat 946921 attttttcca tgtttcatat gacgaagaaa gctttgcctc acctgcaaga ggggtgtgcc 946981 attattaata cgacatcgat taccgcttat gaaggggata cggcgttaat tgattattcc 947041 agcacaaagg gtgcgattgt ttcctttacg cgttccatgg cgaagtcgct tgcagataaa 947101 ggcatcagag tgaatgcggt ggcgcccggt ccgatttgga caccgcttat tccggcgaca 947161 ttccctgagg aaaaagtgaa acagcacggc ttggataccc caatgggaag accgggacag 947221 ccggttgagc atgcaggcgc ctatgttctg ctggcgtctg acgaatcttc ctatatgaca 947281 gggcagacca ttcatgtgaa tggcggccgt tttatttcaa cgtaatcaac gaaaaaccag 947341 ctcaagagct ggttttttgt gtggtgaaaa atttcaaaat aaaaaatttg tcgatttttc 947401 taacaatttt gttttcattt ttgcaatttt atatataata ttgagtagga gaaaggaatg 947461 attcgcgacc agtacaaata tagtagaaaa aaaagaataa tgaccattgt tactcatgaa 947521 ttcagaaaat tcaaataaaa tatataaaaa tagatgatcg ggagttgaag gggaatgaaa 947581 gggagcgttt ttaggaagaa aagcattcag gatttaatcg ctgcgacgag cggggaaaag 947641 tctttaaaaa gagaattagg ggcatttgat ttaacgttgc ttggaatcgg cgccattatt 947701 ggcacaggga tttttgttct gacgggaaca ggcgcagtca cggccggtcc cgggctgacg 947761 atttcatttg ttgtggcggc gttggcttgt ttattcgccg ccctgtctta cgcggaattt 947821 gcgtcaagtg tgcctgtttc aggttcggtg tatacattca cttatgcgac attgggagag 947881 cttatggcct ttattatcgg gtgggattta attttagaat acatgctggc ggtaagtgca 947941 gtgtcggtcg gctggtctgg ttatttccaa tcgtttttat cagggcttgg cattcatctt 948001 ccggttgctt taacagcggc accgggcgca gtgaaaggca cctttaccct gtttaatctt 948061 cctgcattcg tcattgtaat ggcgatcaca tatttgcttt atttaggcat caaagaatca 948121 aaaagagtca acaatatcat ggttatcttg aagatactgg ttgttctgct gtttatcgcg 948181 gtggcagccg tttacgtgaa gccgcacaac tggcagccgt ttatgccaat gggctttggc 948241 ggcgtgttca gtgcagcggc gctcgtattc tttgctttta tcggatttga cgctgtatcc 948301 tctgctgcgg aagaaacgaa aaatcccgcg aaggatctgc ctaaaggcat tattttctct 948361 ttactggtct gcacgatttt atatgtcacc gtatcagcca tcatgactgg ggttatcccg 948421 tttgctcaat ttgcgggtgt ggatcatccg gtttctcttg ttcttcaaag cgcagggcaa 948481 aattgggtgg caggcatcat tgatattggc gccgtgttgg gaatgacaac agttatgctc 948541 gtgatgcttt acgggcagac ccgcgtcatg tttgccatgt cgcgtgacgg acttgtgccg 948601 ggttcacttt ctaaagtgca tccaaagcac aaaacacctt atgtagccac ttggtttttc 948661 ggaacgatgt cggcgcttct cggctcactt gttccgctgg atgaacttgc aaagctggtg 948721 aacatcggga cgttgtcggc atttgtcctg atttctgtgg cagttatcgt tttgagaaag 948781 aaacagcctg atcttccgag agcttttaaa tgcccgggag ttcccgtgat cccaggcctg 948841 gcgattctgt tctgcctgtt cttgatttta aatctgggat gggtgacgat tgtccgcttc 948901 ctagtgtggc tgttaatcgg cttggtaatc tatttcctgt attcaagaaa gcattcaaaa 948961 ttaaatcaat aaccttttga taaagagagc ggccatacag gccgcctctt ttctgttctt 949021 ggcaaatgaa tctatagaaa tgaagacaaa aataagagat aatataggct ggaaaggaag 949081 tgacgtttat tgtctgagca aaaaccagtc caatgggctt cgaaaattgg tttcgtcatg 949141 gcagcggccg gctcggctat cggcttgggc gcgatttgga agttccctta cgtagcgggg 949201 accaatgggg gaggagcctt ttttcttatc ttcgtgttat ttaccatcct cttaggctat 949261 ccgcttttgg tgggggaatt tatttttgga agacggaacc agacgaatgc cattgatgca 949321 tataaaaaag aagcgccgcg atcagcttgg tttcttacgg ggtggatcgg cgtagcggcg 949381 tgtttcttag tgctgtcgtt ttacagtgta atcgggggat ggattttgct gtatatcgtg 949441 aaaacagcgt caggatcact gtccgggctt tctcaagcac agtatggcgc tctttttgct 949501 tctattatcc aaaatccggt gcagacgctc gcggctcagc ttgtctttat ggcactgact 949561 gtactcgttg tcgcaagagg ggttcaaaaa gggattgaac gggtaagcgc ggtgatgatg 949621 ccgattttgt ttttattgtt tattctgctc gttcttcggt ctcttacgct taatggtgca 949681 atggaaggcg taaagtttct gcttgtgcct catttcggcg atctgactcc ggaatccata 949741 ttattcgcgc tgggacaggc cttctttacg ttaacactgg gggtttcggt gatggtgacc 949801 tacagctcct atttgccgaa aacacaaaat atccctcgtt cggcagcctc cattgtcttg 949861 atgaatatca ttgtgacact cttggcaggt ttggctattt ttccggcggt tttctcattc 949921 ggttttcagc caaatgaagg accgacattg ctgtttacag tgcttccggc cgtttttgaa 949981 cagcttccgt tcggcacatt gttttttatc ggctttctcg ttgcattttt atttgcagcc 950041 ttaacctcag cattttcgat ggttgaaatt atcgttgcca caatcggaaa aggggacgaa 950101 aagaagagaa aaaaactgtc atggacgagc gggcttttga tctttttggt cggaatccca 950161 tgctgcttgt cttatggcgt tttgagtgat gtgcacctat ttggcaaaac gttttttgat 950221 attgccgatt ttaccgtcag caatgttttg atgccttcag gcgctctgtt aatttctcta 950281 tttatcccgc tgaaaatttc gaaaagcgaa ctcttggctg aaatgcgaaa tggatcaaat 950341 gcaggtaaag cattctttta cacatggttt tatttgcttc gttttatcgt gccgcttgcc 950401 attattatcg tgttcttaaa tttaatcgga attttatcat tttaaaaaac aggctccgtt 950461 tccggggcct gttttttatt taataagatg atatcaacgg tgcccatgcc gttttcagtt 950521 tttggatgcc gagcctgatg tcctcttctg acaaaccgcc ataaccgatt aagacagaag 950581 taaaaggcgt ctgttctata tatgagggag acacgggata gagggttaca ccgtggtcag 950641 cggctgcttg tattgcttct tcctcacttg ctggaaacaa aaggcgcagc agaatgtgaa 950701 gccccgagtt cttaccgaga atctcaacgg tgtttcccag ttcagagcga atggcttcta 950761 acaggacagc gtgttttttt cggtataagc ttctcattct atttatgtgt ttttgccact 950821 ctccggtttc gatgaagtct gccagtgcca attgcgagtg ggcagaaacg gtctgcttca 950881 ttaactgaac attgttttgg atcggttcca tgagttcagg gggcacaatc atgaagctga 950941 gccgcaagga aggcagaagt gactttgaaa aagtgcccag atatatgact ctgccattcg 951001 gatcaagacc ctgtaaagac ggaatgggat ggccgctgta gcgaaattct ccatcgtaat 951061 catcttctat aatgaatgaa tttgtttctg ccgcccatgc cagcagctcc tgtctgcggg 951121 taatcgtcat aatggtccca atcggaaact gatgcgaagg agtcgtatac atgagataag 951181 gattctgacg gtagagctca tccggcagga cgccttctgc atcagaacaa atcggagtga 951241 catccatgtg atttgcttca aacatccttc ttgaacggtg aaagcccggt tcttcaaagc 951301 cgatttttgt acctggcttt agcgaaaggc aaagattttg cagaagcacg gtggttcctg 951361 cgccgatgat aatctggccg ggttcacaat ttactccccg agacagcctg acgaatcggg 951421 caatcatgtg cctgagttcg tattctcctt gagggtcgcc agaggtgtga aacgatccgg 951481 aatagcgatc aagacttttt actatgcttt ttctccatgc gttaaaggga aagagggtcg 951541 gatcaacgct gccctgatgg aagtcaatag caggtgcgtt tttttgatgt aatcccggct 951601 gtacagactg ctgaaaatgg tcaggagctg tcgggaatcc tggttctact tccgccgcga 951661 accagccgat tttcggcttg cttttgacat agccctcagc agttaattgc tcataagctc 951721 gttctatagt tgccgtgctg acatcgagca agctggagag cctgcgtttt gacggaagtc 951781 ttgttccctt tgtgattcgc gcatgtgaaa tttcttgttt aaaaaaggta taaagctgtt 951841 catacagcgg tgttttgctc tttttatcaa gaaacggcgt aatatccatc tcatgtctcc 951901 tttgtagctg gcatggtcat tttttctgat attggctatt tggcaaatgc catttattag 951961 ctatgatcat tgtaacgaaa ggaaagggga ttgagaagat gatccatatg aaacaattaa 952021 cctcgaaaga agaatgggct gagtcgtatc cgattatgag tgaattgaga acagaactgg 952081 atatagagac gtatttacaa aggcttgaag cctgtgtgca gaaagaatcg tatatgctgt 952141 ttgccttata tgaaaataca gcaatcagag cgctgtgcgg ggctctgccg agagtttcca 952201 ttcataaagg agagcacttg tggattgcgg atcttgttac aacggcacct tgccgatcaa 952261 agggatacgg caaaatgctt ttggattatg cctcagactg ggcgagaaaa gccggactcg 952321 gttttgtcag tctttcatct ggccttcagc gtaaagacgc acatcgattt tatacagata 952381 aaatgggttt tactatagaa agttatttgt tccgaaaacc ggtataacga aaaaagacgc 952441 ctgaaaaggc gtctttttta aaagccaaac tgtaaattcg tatctacaga tacaatggta 952501 tacacacaaa taatcacaaa gagattaagg atgacgccga gcaggcctgg acctgtgcgc 952561 cctctcttga tgaagagttc aacaacgccg aacggaacgg cagccatggc gaacggaagc 952621 atttgatagg aataaaacgt gacgttgctg ataatggcca aattcagcaa cagcagggac 952681 agaaccgctg tcccgacaga gatccagccg aatacattgt gttctttaaa aattcttacc 952741 agttccataa ttccacctcg ccgacattcg ctgattttac agatttattt ttcagcatgc 952801 gctggatttc cttggttggc cctgtaacga ccgaaccgta tacattgaca ccgtttttct 952861 ctacataatc taatcggtta tctacattca ggtctttccg ttttgaaatg acctgagccc 952921 atttttcgtg tttggacatg aatttcaggg cgttgataaa ctgatcgcca ttcgacttgc 952981 cttttgtatt aagggcggcc aagaactttg aatcctttcc aggatagcca agaggttctg 953041 tggaagctgt cttatttgtg tttttctctg tttcgattgc gttccacaaa aagctcacat 953101 catagccttt gaatttgtta tacacgtctt ttgtcggata tgcacggtca tatgaaaggt 953161 agacctctga taccgttcct tcaggcaatg tgcttaacgt tttttctgct tttgcggtcg 953221 tttgttcaga cttgtttgaa ggatgtgtaa agtaatggcc ggttttattc acttctaagt 953281 catagtagtt tactgccggc gcttttactt tgttataaaa catttcaacc cgttcattcc 953341 ctacggcagc cgtcttcgtg ccaatctgct tttgcagcgg gaattccgta ttcattccaa 953401 atagcttcac ttggcttttc agtccggaag tatcaacaag aacattcggc atggtcaggg 953461 ctacagtgac tgcggcagtt tccataaact cattgccggt gctgtgtttt ccacccattc 953521 cgtaatagag gtagcttccc agcgtacaaa gcggcaaaat catcaatgtc gaaatgacgg 953581 caagcacaga aattcgcaaa taagacttgc gtttgccgta ggctaaaatc gctttttgtt 953641 tttcaggact gatgctgaga tcccaatcgt tatcgtcctc tagttcgctg tcaatcagtt 953701 cctgatatac ttcaagcttc tcgagttctt cctcaaatgc agtcatttcc tggtcgctca 953761 tttccccatt tttatattga tcaaaacgct ttttaaattc ttcattcatc attaacacct 953821 ctattataaa gtgctttcag ccgctgtctg gcacgaaata aaacactttt aaaattcgcc 953881 tctgaaatat tcataatatg ggatgcttct ttgtagttta actcttttaa ataatatagc 953941 gttaaggcct cccgataatt atcggggagc tcggacatat aaccagtcag cacttccttt 954001 atctctacct gatgggcagg actttgaaca gcattttgaa agaggcttcc gattaagtca 954061 tcagaaatgg ttacttcttt cttatgcttt ctgacgtaat caatgaaggc gtttcgcgcc 954121 acttgaaaaa gccagggctt tactttgctg tgatcatagg agtgaatgtg tatgtatgcc 954181 cgcataaagg tttcctgcag taagtcttca gcaagatgct tgtcttttgt catggagagc 954241 aggaacctgt aaacatcatt catgtacatt tggtaaattt catcgatcgt cactgccttt 954301 tctcccctct atgttataca cgcataagaa aggtttaaag ttgcacatta catgcaaacg 954361 gcttttttat acctaatcaa acaccattac tatatagtac ccaaaaatgg ccgcaaaaga 954421 tagtgcggag aaaggtttaa cattttttcc agaggggaaa agatagtgaa aaagtgaagg 954481 agtggcacaa tggaatatac cagtatagca gatacaggaa tagaagcctc cagaatcggc 954541 ctcggcacat gggccattgg cggaacgatg tggggaggca ctgacgaaaa aacatcgatt 954601 gaaacaatcc gcgccgctct tgatcagggg attacactga ttgacaccgc accggcttac 954661 ggcttcgggc agtccgagga aattgtcgga aaggcaatca aagagtacgg caaaagagac 954721 caggtgattc tcgcaacgaa aacggctctg gactggaaga acaaccagct gttccgccat 954781 gcgaacagag cgagaattgt agaggaagtt gagaattctt tgaagcggct tcaaacagac 954841 tatattgatc tttatcaggt gcattggccc gatccgcttg tgccaattga agaaacggct 954901 gaagtcatga aggaattata tgatgcggga aaaatccggg cgattggcgt cagcaatttt 954961 tcaattgagc aaatggatac atttcgcgcc gtcgcacctc tccatacgat tcagcctcca 955021 tataatctgt ttgaaagaga gatggaagag agtgtccttc cttatgcgaa agataacaag 955081 ataacaacat tattatacgg cagtttatgc agagggctgt taacaggcaa aatgactgaa 955141 gaatatacat ttgagggcga tgatctgcgt aatcacgatc caaaattcca gaagccccgc 955201 tttaaagagt atctttctgc tgtgaatcaa ttggataagc tggcgaagac acgttatgga 955261 aaatcagtga ttcacttggc tgtcagatgg atcttagatc agccgggagc ggatatcgct 955321 ctttggggag caagaaagcc tgggcagctt gaggccctat ctgagattac aggctggacg 955381 ctgaacagtg aagatcagaa agatatcaat actatattgg aaaatacgat atcagaccct 955441 gtcggaccgg agtttatggc cccgccgacc agagaggaaa tataacaaaa gctgagggcg 955501 aatcctcagc tttttggcgt ttaaacgaga gaaatcttaa aaattagtac caggtaataa 955561 aaaatattgt tataatagat gacagaaaga atcattgatt acgacaaagg aagtgcgata 955621 tgtataagtt ttgtgcaaat gctttaaaag ttattctttc tcttcgcgga ggagtgaagg 955681 tgtataacaa agaaaacctt ccggccgatt caggttttgt catcgcgtgt acacattccg 955741 gctgggttga tgtgattaca ctcggagtcg ggattcttcc ttatcaaata cactacatgg 955801 cgaaaaaaga gctttttcaa aataaatgga tcggttcgtt tctgaagaaa attcatgcct 955861 ttccggtaga tcgggaaaat cccgggccaa gcagtattaa aacgccgatt aagctgctga 955921 aagaaggaga gatcgtcggt atcttcccaa gcggaacaag aacctctgag gatgtgcctt 955981 tgaaaagagg tgcggtgacg attgcgcaaa tggggaaagc gccgcttgtc cccgctgcat 956041 atcagggccc ttcaagcgga aaagaattat tcaaaaaagg aaaaatgaag ctgattatcg 956101 gtgagcctct tcaccaggct gattttgccc acctgccttc aaaggaaaga cttgcagcaa 956161 tgacagaggc tttgaatcag cggattaaag aactagagaa taaacttgat cagctataag 956221 gcgttctgag agattgtcct gaaactgtga aaataagaaa agcaccctat acaaggtgct 956281 tttcttatta tgcttcctgc tggttagctg tctccagaag ttcttcttct tgaagctttt 956341 tcacttcaat atatgcgacg tggtggccgt caatttcatt aatgatgaat tcgcagccct 956401 cttcgatgat ggaatcatct ttttcaacat cgtatttttg agtaaggaac cagccgccga 956461 ttgtatcgac ttcttcgttc tctaaatgga tgcctagcag gtcgtttact tggtcaatta 956521 acacttttcc gtcaagaata taatggcctt cgccgatttt gcggatttcg ctaatttcat 956581 caatatcaaa ttcgtcgcgg atttcaccga caatttcctc aatgatgtcc tcaaccgtca 956641 caagcccggc agtaccgccg tattcatcag acaaaatggc catgtggacc ctctcttttt 956701 gcattttgac aagcaggtct tggatcggcg cagattcaat gacatgaatg atagggttga 956761 cgaattgaga aatggtggaa tcaacagata cctcaccgct gatgcaggcg gtcagcactt 956821 ctttaatgtt aataaccccg ataatgttat ctttatcgcc ctcttccaca gggtagcggg 956881 tatatttttc aatctgaatg atgtccatca tttcagaaat cttgatatca tgcggaaggc 956941 tgacaatttc ggtccgcgga atcataattt ctttcgcgag cctgtcgtca aattcaaaga 957001 ttttattcac atatttaaac tctgattggt tgatttcacc gcttttatag ctttcagaca 957061 aaatgattcg cagctcttct tctgagtgag ccagttcgtt ttctgaaacg gtctccaggc 957121 caaatgcttt ggtcaataac cgtgcggaat tgttcaaaag ccaaatgaat gggaacgcga 957181 tgcggtaaaa ccaaatcagc ggtttcgcaa acagcataga cactgcttcc gccttttgga 957241 tagcgactgt tttaggtgca agttctccga caacaacgtg taagaacgtg ataatggcat 957301 acgcaaaaat aaacgatatg acatgtgaaa gggaacctgg aacgttcatt tggacgaaaa 957361 gcgggtgaag cagcctttcg atcgttgatt cacctaaaac ccctaatccg atggaagtca 957421 atgtaattcc gagctgacac gcagataaat attcatcaag atgcgtggtc acttttttta 957481 cggctattgc tgctttattt ccttccgcga tcagctgatc gatccgtgag cctctgattc 957541 tgataatggc aaactcagat gccacgaaaa atgccgtcag ggcgattaaa acagcaacta 957601 aaatcaaatt cactatgtcc aattagaacc ttcactctag caatgagaat gaaggtaaca 957661 cctcctgtta gataaaatgg ttttaactta acagcagcat aaatgattgg aacacggcga 957721 gcttttcagg cgggagtttg cttttcagct tgtcacgatc ctcgggcttc agccgttcaa 957781 accgatgcaa gattccggag atgttttgat tcatatgatc aatttctaat gccagatttc 957841 caatttcatc atcaagttta gctgaagagg gaaactggtt ctccagtcga tctttaatat 957901 cggacagggc caatcgctgc ttcttgcaat ctacaataaa tataagtcgt ttgagtgcat 957961 tttcgtcgta gtaacggtaa tttgaacagg atctggccgg cgtaagcaga ccgagattcg 958021 tataataatc aactgtccgt ttcgttactc cggcgagtgc cgctagttca ctgatgcgat 958081 aagtctcagc cccatctata tccctcccaa ccatcacgtt atagttatga gaatagttta 958141 atatatgaac ggtgtcttgc acaagtttat tgtttttttt agaccggaat tggaagttgt 958201 ggaattcatc atctgattga agtaacatag gaagatagaa ttttcaaatt tttatatgcg 958261 gaagggacag atgaaattgg ctgggttatc ccgggaagtt gaagaaaact taaataaagg 958321 atcatggatt cgcaagctgt ttgatgaagg tgcaaggctg aagaaggagt tcggggaaga 958381 ccaggtattt gatttttcac tcggcaaccc gattgttgaa ccgcctgaag cttttaagag 958441 agcgttaata gaggaagctg aaaaaggcag ccacggatac atacaaaacc aagggcttct 958501 tgcagcgaga gaaaaagtcg cgcaatttct gggctcgcgt tttgaagctg atttctcagc 958561 ggagcgcatc gtcatgacgg tgggcgcggg aggcgctttg aatgttgcgt taaaaagcat 958621 cgtaaaccct ggggaagagg tcattattct tgcaccttat tttgccgaat ataagttgta 958681 tattgagaac tacgggggaa aagccgtcag ctgcccgttg acaagccggt ttgagatcga 958741 cattgaagcg gtaaggcaat cgatcactcc acagacgaaa gggctgattc tcaatacacc 958801 gcataacccc acaggcactg ttctcagcca gaaaaatata gacgatttag gcgctttatt 958861 aaaagaaata gaagagaaga gcggccagac gatttatgtg ctgtttgatg aaccgtacag 958921 tcaattaatc tatgatgaag agctggcaaa tccgtttcaa tcgtaccatc gtgtgatatt 958981 ggccagctca ttcagtaaag atctcggcat agccggagag cggctcgggt atatcggatt 959041 ggacagccga atgccggatg cggacctttt gatcaacgct tttgtgtatt gtaatcgaac 959101 gcttggattt gtgaatgccc ctgtcatgat gcagcgggct gtggcacgaa tggatgattt 959161 aagagtagac gcgagcgctt ataaagagcg ccgggattta atggtagaca ttttaaaaga 959221 agccggtttt gaatttgaaa tgccaaaggg aggtttcttt gtttttccga aatcgccgat 959281 tgaagatgaa gttgcatttt gcgtgcatgc cgcccaaaaa tacaaattat taattgtgcc 959341 gagcagcggt tttggaatga gcgggcattt ccgattatcc ttcagtgtgc cgatcgagca 959401 gattaaaaac tcacgggaca ttttcatttc tttatataaa gattttgctt aagaaggcaa 959461 agaaaagaaa acagttttca aggctgtttt ctttttatat ccgcaaaatc cttcctcttc 959521 caatccagac aggcgcagaa ttgacaagca ggcatgcagt taaggctttc ttcatgataa 959581 aagtctaaaa attaaaaatc atttttggaa tgagttgtgt tacaataaaa tatacaattt 959641 ataatcaaac tttgactttt ggaggtggta tgatggggcc ctctgcttag gcaacaatac 959701 accgcgtacc tcaatgttaa ggaaaaatga ttatatcagg aggtgactcc ttatcctttg 959761 ttgagaggat agggttaaat ggacgatatt gacagtctga ttttaattgg cgtgctcatt 959821 gctttaaccg cgtttttcgt tgcaagcgag tttgcgattg ttagagtgag gagatccaga 959881 atagatcagc ttatcacaga aggaaacaaa cgggcgatac tcgcaaggcg tgtcattaca 959941 gatttggatg aatatttatc cgcatcccag ctaggcatta cattgacatc aatcgggctt 960001 ggcgtactgg gtgagccggc ctttgaacgg ctgctgcatc cactgtttga accgctcggc 960061 ttgccggact cggtttcaca tgcagtctct tttgcagtcg cgtacggctt gatcacgttc 960121 ctgcacgttg ttgtaggtga actggccccg aaaacggtcg cgattcaaaa ggcagaacag 960181 ctgactttac tgatagcggg ccctttgcgt ttattctatt tgctcctgtt tccgtttatt 960241 tggatcctca atggatcggc gcggctttta tgcgggatgt tcggtttgaa gcctgcgtca 960301 gaacatgatg gttcccattc tgaggaagaa ctcaggatgc tgttatctga gagtttaaaa 960361 aacggagaga ttaatccgtc tgaatataaa tatgtgaata agatttttga atttgataat 960421 cggatcgcca aagaaattat gataccgcgg aaggaaatgg ctgctgtgtc aactgagatg 960481 acgatggccg agatgcttga agtcatgctg aaggaaaaat acacgcgctg gccagtcaca 960541 gatggagaca aagacagtgt gctcggtttg gtcaatacga agcatttgtt ttctgatttg 960601 ctgtttatga cagaagaaga acgaatgaag atgacgatcc atccgtatgt gaggccggtc 960661 atcgaagtga ttgaaacgat cccggttcat gacttgctga ttaaaatgca gcgcgagcgc 960721 attcatatgg ctatattgtc ggatgaatac ggaggaacct cgggacttgt gacgacagag 960781 gatattcttg aggaaattgt cggagagatc cgagatgaat ttgatgaaga tgaacagccg 960841 ctgatccaaa agcttggcga cggccattat gtgatggatg gaaaggttcg gatcgatcag 960901 gtgaacagcc ttcttggcgc atcgattcaa gaagacgtcg atacgatcgg cgggctgata 960961 ttaaaagaaa acatcgatat tgaggctggt gaatccattc gcatcggttc atatacgata 961021 aaggtgctga agatggacgg ccgattaatc aagcaaatcg atataaaaga agaagccggc 961081 aacacaaccg ggattacggc gcaccacaag ctgccgctgc ccgagcctgt gatgctgaac 961141 agtgcaacct tgagcgagaa ataagctcaa ggttttttta tattgtgatt gtccagccgc 961201 accaaaatgc aaaaagcgac ccgcaaagtg tcaggacgat gtacaagatg ctttctttta 961261 cacgtttggc cataaggagt tgaatagttt caacgctgaa tgtggaaaag gtcgtaaagg 961321 cgccaaaaaa ccccgtgcca atgataagcg agaccgaagc atttgcaacg tgaagtcctg 961381 taaatattcc gagcccgaga gctccgagaa tattgactgt cagtatgcca atgggcaggc 961441 tgagaccttt ggttttggcg gttatgacat tgccaagcca gaagcgaagc attgcgccaa 961501 gtccgccccc tatgaaaata cccgctagtg tcatttttcc tgcagcccct ttctttgctg 961561 aatgcctgct atgcgccgtc ccacaaaaac accaatcagt gcaaatatga tccctgatat 961621 caatgaggct gccacatata aaagagccaa tgagggttgt ccttgcaaaa gcatcactgt 961681 ttccttagaa aacgtggaca ttgttgtgaa gcctccgcaa aagccggtgc ctaaaaaagc 961741 cgacagcaga ggccgttttg ccccgatcat aaaaaatccg gtcaaaatgc ctaatagaag 961801 gctgcctgcc gcattttcca gccaggttgc cgccgggaac tgaccggtgt gtatccataa 961861 gtttaatccg tatcggaggc aggcgccaag cgcgcctccg ataaaaaccg cgctatatat 961921 tttcatgttt gccatccttt atgatgaaat ccgggtaatc tgtaacgatg ccgtccacgc 961981 ccatggcttg taattttgcc gctgtctttt gattgttgac agtccatgca aatatgttta 962041 agccattttt attgatggag ccgatcatca gacggttaag ccgtgtgtgt tttatattga 962101 catagtttgc aaaagagcgg aaggccttca tctgatttct ggacagcatg ccaaagttgg 962161 gccttgtaat gaccgctgtc ggaatcgaag gataaagctc gcggaacctt tggacggagc 962221 ggaactgaaa ggattgaaca atattattga tagaaaaaga aaattgccct aatagctgtc 962281 ccacctcttc ttcaattccg acttgagacg gatggccttt tagttcaatt aaaaggccga 962341 tttttttgtg gtagcgcttg agcaccgctt ccagggttgg aatacgctct ccttgaaaag 962401 cgggaccgta ccagcttcct gcatcgagtt tttgcaattc ctccaaggta aaatccttaa 962461 caaagcccga tccgtttgtt gttcggtcaa ccctgtcatc gtgtatcaca acaatctgcc 962521 tgtcttttgt aagctggaca tccagttcga tcatatctgc attcattttc accgcaaggt 962581 caaatgcggc aatcgtattt tccggagcgt agccggatgc tccgcgatgg gcaatgatgt 962641 acaagctaag tcagctcctc gtatgggcat ttctgttatt gtatcaaatc catatatgca 962701 ccgcgataca aactggtgaa ttttttctgc catatcggaa tggtccgggc tgaggaatgc 962761 gtataactaa aaaaagacac tcagcgtatc agaacacatt tcgtcagaaa attaggtctt 962821 tcgacatgtt cacaacaaaa tatgatcctt tataatagca aaaaaggagg cgagatcatg 962881 ggaaaaggga gaatcagagt ggaggaaaga attaaagccg aaacggatgc tgaaatgcaa 962941 aaagcaactc tccttgatca gacacaaacg aaaaaaggta agtgactgtc cctattgaat 963001 ctggctgata gatgaattga gaaatgaccc cggcgtttcg ccggggtttt gtgctgcata 963061 agacatttaa atgaacatcc ttacgaatat tttagtataa taaacaattg attgggatag 963121 aggggagaca gtcatgccgg attatctgca gcagtatttt acgcttgata acatcataca 963181 aatcggcatc agcttggcga ttttgctggt gtttcttata cttagaaaat tattcacaag 963241 atattttttt aacctgcttt ttaatttgac aaaccggccg aaaacagaaa tttttaaaca 963301 ggtggttctg gcgtttgata agccggccag atggtttttt gttgcccttg ggctgttttt 963361 agcgatccgg tattcaccgt ttttagatga gcaaatgccg gtcatcagca aaatataccg 963421 ctcactgatt gtggcgctct tgtgttgggg tctttgtaat ttgaccgcaa catcgtcgtt 963481 tatcttccat aaggtgaacc agcgcttcga gcttgacatg gatgacattc tggccccgtt 963541 tttatccaaa ttgctccgtt ttgtgatcat tgcgctcagt gtcagtgtga tcgctcagga 963601 attcaattat gatgtcaacg gatttgtagc gggccttggt cttggcggac tggcttttgc 963661 gcttgccgcg aaggatacca tcagcaactt cttcggcggt attatcatta ttactgaaaa 963721 gccgtttaca attggtgact gggtggagac gtcgacagta acaggatcag tcgaggatat 963781 tacctttagg agcacgagat tcagaacagc acagggggcg cttgtaacgg tgccgaactc 963841 tacgctgtcg atggaagcga tcacgaactg gacaagaatg accaaacgcc agattacgtt 963901 ttccatccat gtgtcctacg ctacgccgat tgagaacctt gaacgctcca ttcattctct 963961 cagaacaatg ctcttagagc atgagggcgt tgataatgaa ataatcatgg tcaactttga 964021 tacgtttgcc gacagctact acaatttatt ttttaacttc tatacaaaaa cgacggtttg 964081 ggctgaaaac cttaatatta gagaggatat caactataaa attattgaga ttttaggtgc 964141 agaaggcgtt cagtttgcat atcccggcca aatggttgtt gtcaagcaaa agcacgaaag 964201 cgaccaattc caggtgaatc taaataaaga ggaaaaggaa cgggcttaaa agagagactt 964261 cgtctgacag aggcggagtc tttttcatgg taaaataaga gaaaaaggcg gtgttgagtt 964321 ggaaacattc aaaagtattc tacatgaagc acagagaatt gttgtgctga ccggagcggg 964381 aatgagcaca gaatcaggga tccccgactt tcgttcagca gggggcattt ggacggagga 964441 tgcctcaaga atggaagcga tgagccttga ttatttttta agttatccgc gtctgttttg 964501 gcccaaattc aaagaattgt tccagatgaa aatgagcggc agctttgaac cgaatgaagg 964561 ccatttgctt ttagctgagc tggagaagca agggaagcag gtcgatattt tcacgcaaaa 964621 cattgacggt cttcataaaa aagcggggag caggcatgtg tacgaactgc atggttctat 964681 ccagacagca gcttgtccgg catgcggcgc ccgatatgat cttccccatt tgctggagcg 964741 ggaggtgccg gagtgcacgg cggccggaaa caatggggac atttgcggaa cggtattaaa 964801 aaccgatgtt gttctctttg gcgatgccgt catgcacttt gacacccttt atgaaaagct 964861 ggatcaagca gatcttttat tggttatcgg cacgtctctc gaagtggctc cggctagatt 964921 tgtgcctgag gatgcaagcc tgattcccgg catgaagaaa gtcatcataa accttgaacc 964981 aacgtattgc gacagcttgt ttgacatggt catccatcaa aaaatcggcg agtttgcccg 965041 aagtttgggc atgaaaaagt gagccgcttt atgcgcctca cttttttatt catgaacagg 965101 aaccattgtg tcctctaaca ctccgaagga atagcctttt tcttttaatt tattgattag 965161 taccggcagc gcatttacag tagcaggaag atcatgcatg agaattacat ttgggcggct 965221 tgaagagctg tgttccatat tctcaagctg ctgtaatacg gcggtcacat actgtgaatt 965281 ccggtatttc cagtccatgc tgtcgatcgt ccaatcccag tacacaaacc catctttctc 965341 cagattgcga atttgtgagg cggttagtga cggcttgctt ccgtatggcg ttctgacaag 965401 atcggtttta tatcctgtaa tgtcctgcag cgtgtcacgc gcctcctgca tttcttttag 965461 cggagatgtc ggtgtttgat agaacaatct gttattgtgg gtaacgccat gtaaaccgag 965521 tgcgtggcct tccttttctg ctcttttcac agcctgcttg aattcgttca tccgcggtga 965581 cagcataaaa aacgtcgctt ttacatcagc gcttttcagt acgtcgagca agcgggttgt 965641 aacggctgaa gggccgtcgt cgaaggttaa gtaaaccgtt ttatctccca tgttctgctt 965701 tgtctgcaga tgttttatca ggagatcggg ggagtcgttt ttcagcttaa ggctttcctt 965761 ctcatctcga agctggccgt ttgttgtgac agtgacttcc tttgctttcg ttgaactgtt 965821 ggaataaccc aaaatcacca taagcaaaag cagcacacat aaaactgcta aacttgcaaa 965881 tttaaaagca agcgaaactg cagaaggaga agcctctcct ctcgtttgtc gcataacaat 965941 ctctccattg gcataaaatc tctacataat gctgtacagc aggcagctta tgaagatgcc 966001 ttatgtttac aacctatgta ttaccagtca agtatacagg aataaaactg gaaagcacat 966061 agaaaatttg tcgaaatgtc agattttaag gaaaaaataa actcctttcc gctatagatc 966121 tcttgatctt tctgtttttc agcttgtcca atatggtaga attagtgata atgacagctt 966181 gaatgacatc agggacatct cgaaaaggga gggcttttat gaaggtttta gtcaatggcc 966241 ggctgattgg gcgcagtgaa gcatcaatcg atttggaaga tcgcggttat cagtttggtg 966301 acggcatcta tgaagtgatc agggtgtaca aaggagtatt gttcggctta cgtgagcatg 966361 cagagcgttt tttcagaagt gctgctgaaa tcggaatttc actgccattc agtatagaag 966421 atctcgagtg ggacctgcaa aagcttgtac aggaaaatgc ggtcagtgag ggagcggtat 966481 acattcagac aacaagaggt gtggccccgc gaaaacacca gtatgaagcc ggcctcgagc 966541 cgcagactac tgcctatacg tttacggtga aaaaaccgga gcaagagcag gcatacggag 966601 tggcggccat tacagatgag gatcttcgct ggttaagatg tgatatcaaa agtctgaatt 966661 tactgtataa tgtcatgacg aagcaaaggg cctatgaagc cggagcattt gaagccattt 966721 tacttaggga cggcgttgtt acggagggta catcctctaa cgtttatgcc gttatcaacg 966781 gcacagtgcg aacacatccg gctaatcggc tcattctcaa tggaattaca cggatgaata 966841 ttttaggact gattgagaag aatgggatca aactggatga gactcctgtc agtgaagaag 966901 agttgaaaca ggcggaagag atctttattt cgtcaacgac ggcagaaatt attccggtcg 966961 tgacgctcga tggacaatcg atcggaagcg ggaaacccgg accggtgacc aaacagcttc 967021 aggctgcttt tcaagaaagc attcaacagg ctgctagcat ttcataaatg aacgaagaaa 967081 agagcccgct ttttacagcg gggctctttt tattttttaa caaatccaat caaaatggag 967141 atcattggcg atatatagag gaagaacgta aatgggatgt agtctatgac tggaacacca 967201 agtgcgctcg ccataaatgc gccgctgacg ccccaaggaa tcaatgggtt aattaatgtt 967261 ccgccgtcct ctaatgatct tgtcagaaat tttcgctgga tgtttcgttt gtcatataaa 967321 gatttaaatg attgtcccgg tattaatatc gataaatact gttcgcccgt tgccaagttg 967381 acgccgatgc ttgagcagac agttgctgca acaagacggc cttttgagcg gatgcctttc 967441 atgacgcctt ccaatagtgc agaaatcaat ccgattttct ccatcaatcc gccgagtgca 967501 aaagcaatca taatgagaga gacagagccc atcatggatt gcagtccgcc tctgttaata 967561 attttagcgg ctgcctcatt gtcagtttcg aaagttgtgc cattttgtaa agctgtcata 967621 aacgcctgca ggctgctgta gggtacaaaa atagcagtca aaattcccga ggaaataatt 967681 ccggcagtca gaacggggat tactgatacc cgtttcattg ccagcaaaac gactaagagc 967741 ggagaaagaa gggcccacgg tgtcacgttt gcagcatctt ttattccggt tatgacctgc 967801 tgaatattat cggttgaagc agcgtccgct gacactgatg aaccgagaaa gtaaaacaga 967861 acgacagtga tgagcaaagc tggaatggtt gtgcccatca tatggcgaat gtgttcaaag 967921 attggtattt cgcctattcc ggctgcaaag ttggttgtgt ccgacatcgg cgacatttta 967981 tccccaaaac aagcgccgca tatgactgcg cctgctgtcc attcaagcgg aacgccagcc 968041 gcgctcgcca cgccgatcag cgctactccg attgtgctta cagttgtcag acttgagcca 968101 acaagtgtgc tgatgatcat acatgaaaac aaagcagtca acagaaggtg gcttggttca 968161 ataaaggata gggcataaac tgtcatagtc ggtattgcgc cgctgtacat ccaggcgccg 968221 attaagatgc cgatcagcgc tagaacaata atcggctgta cgccgttttt gatcccgtct 968281 acaatccctt tttcaatgct cttccaggga aatccaaacc ataaagctgc tgctgaaagc 968341 atgacaacac ttaaaaacag cgggatatga ggttctacat gaagcaagaa taagcaagaa 968401 ataataatgc acaacatgaa tataaataaa ccgacggcta acggaaacgt cagctttttt 968461 tgagaatcca aaataacacc ccatatttat ctttaatgct tttgtgcttt tgggcacgaa 968521 agcattataa cagaaaaaaa cgaaaatcta tgttttttca caattatgaa tataaaagaa 968581 gtgagcacag ggcgtgctca ctttacaatc aggacgggta tatccgattt cgctgaaagc 968641 ttttcactta cacttccgaa tattagcttt ttcagcctgt tttggtctct gcttccggtt 968701 acgatcatat cggcagaaat gcggtttgca tgctcgataa ttgattcagc cggatcgcct 968761 tctaatatat cgatatctcc atctgcctgc tgttcattca gcatcattct ggcttcggcg 968821 atgacttctt ccgtacggtc ttcatagatc attggctcag gtgatgttac atccgatatc 968881 agcggatcag gaacacttgt catgcctccg ctgatatagc ttgcctcagc tgcgggtctg 968941 ggcgggtcga tgacggtctg attgtctttc atatcatgtg aatgggcgac ggtaatagcg 969001 gcatttacgg ttttagcaag atcaatggct gtcagaagcg ctttcttact attttcactt 969061 ccgtcaaacg caacaatgat acggtcagca tggaacatcc ttctcaccct ttcaaagcgt 969121 cttacaacac tactacccga atttgagcac aattaacctt ttcctattca agtaatgatt 969181 gacaataaaa ggttttgttt atatgatgat aaaaagatga aatcagaatg gaaggagggt 969241 ttgctatgcc aaggaatttg cgtgtttatc aaacagtttc atattggcgc ggcaaacctt 969301 ttgttctgtt ttcgtgaacg gttttttagg tcggaccgcg cgctgaaaag cgctgtgcgt 969361 aacatatcgg ttaaaaaagg catggagctg acgcttcatg ccttttttat atacaaaatc 969421 taaggaaaga caggtgtatg ggatgtgaag acaaatacag aggcgagggc agttcgtgcc 969481 aaactggatg aaaaaagctg caaggaaaaa atagaaggcg gctgatgagg agatggggat 969541 agatgttttc agttttgaaa aagcttggct ggttttttaa ggcgtactgg ctgcgctata 969601 cgattgcgat tgtcctttta ttagcagtca atgtcattga aatgtttccg cctaagctct 969661 tggggaacgc catagatgat atgaaagcag gggcatttac tgcggaaggg ctgctgtttt 969721 atatcggtat cttttttgtg ctgacggcgg ccgtgtatat catgtcttat ttttggatgc 969781 atcagctgtt tggcggagcg aatctgatgg agaaaattct tcgtacgaag ctgatggggc 969841 atttgctgac tatgtcgccg ccgttttatg aaaaaaaccg aacaggcgat ttaatggcac 969901 gagggacaaa tgatcttcag gccgtcagtt taaccacagg gtttggcatc ttgacgttag 969961 ttgattctac gatgtttatg atgacgatct ttttgacaat ggggtttttg atcagctgga 970021 agctgacctt tgccgccatt atcccgcttc cagtcatggc gattgcaatc agtctatatg 970081 gaagtaaaat tcatgagcgg tttactgagg cccaaaacgc gttcggggcg ctgaatgaca 970141 gagtgctgga atctgtttca ggcgtgcggg tgattcgcgc gtatgttcag gaaacaaacg 970201 atgttcgccg gtttaatgaa atgaccgctg atgtttatca gaaaaatatg aaagtggctt 970261 ttattgattc actgtttgag ccgacggtaa aactgcttgt cggcgcaagc tatctgattg 970321 ggctcggcta cggagcgttt cttgtattcc ggaacgagct gacgcttgga gagttagtgt 970381 cctttaacgt ttatctcggc atgatgattt ggccgatgtt tgcaatcggt gaactcatta 970441 atgtgatgca gcgcggcaat gcgtcattag atcgggtaaa tgaaactctt tcttatgaaa 970501 cggatgtgac agatccaaaa cagcccgctg atcttaaaga gcctggagat atcgttttca 970561 gtcatgtcag ctttacatat ccaagctcaa caagtgacaa tcttcaggat atttcattta 970621 cggtgcgaaa agggcagact gtcgggattg caggtaaaac cgggagcgga aaaacgacaa 970681 ttattaagca gcttttgcgc cagtatcctc caggtgaagg gagcattaca ttttcaggtg 970741 taccgattca gcaaatccct cttgaccgtc tccgcggatg gatcggatat gtgcctcagg 970801 atcatttact gttttcacgg actgtaaaag aaaatatttt atacggaaaa caggatgcaa 970861 ctgataaaga ggttcagcaa gccattgccg aagcacattt tgaaaaagat ttgcacatgc 970921 ttccgtccgg tctggagaca atggtcggtg aaaaaggcgt ggcactgtca ggcgggcaga 970981 aacaaagaat ttcgatcgcg agagcactca tggcgaatcc ggaaatcttg attctggatg 971041 attcactttc cgctgtagat gccaaaacag aggctgcaat tatcaagaac atcagagaaa 971101 accgcaaagg aaaaacgaca tttattttga cacaccgatt atccgcggta gagcacgctg 971161 acctgatcct tgtgatggac ggcggcgtca ttgctgagag aggcacgcat caagaactgc 971221 tggccaataa tgggtggtac cgggaacaat atgaaagaca gcagctgttc actgcggaag 971281 aagggggagc aggggcatga aaataggaaa aacgttatgg agatacgcac ttctttatcg 971341 aaaattgctg atcacagccg tccttttgct aactgttgcc gtcggtgcag aactgactgg 971401 gccctttatt ggcaaaaaaa tgatagacga ccatatcctc ggcattgaga aaacatggta 971461 tgaagctgcg gaaaaagata aaaatgccgt tcagtttcac ggcgtctcat atgtcagaga 971521 ggaccgattg caggagcctg tttcaaaagc aaaagaagcg catatttatc aagtgggaat 971581 ggcgttctat tttgttgatc aggctgtcag cttcgacggg aatagaacgg tttctgacgg 971641 gaagctgacg atcacaaacg gagacaagag ccgggcatat gctgccgaaa agctgactaa 971701 gcaggaactt ttccagttct atcagccgga aataaaggga atggtgttac tgatctgcct 971761 gtatgggggc ttgcttgtgt tttcggtatt ctttcaatac ggacagcatt atctgctgca 971821 gatgagcgcc aatcggatta ttcaaaagat gaggcaggac gtgttttcgc acatacagaa 971881 aatgccgatt cgctattttg acaaccttcc ggccggaaaa gtcgttgcgc ggattaccaa 971941 tgatacggag gctattaggg atttatatgt cacagtgctt tcaacatttg tgacaagcgg 972001 aatctatatg ttcgggatat tcacggcttt gtttctgctt gatgtgaagc ttgcgtttgt 972061 atgtctggca attgtgccga ttatctggct gtggtcggtc atataccgga gatatgcgtc 972121 atattacaac caaaaaatcc gctcgatcaa cagtgacatt aacgcaaaaa tgaatgagtc 972181 aattcaaggc atgaccatta ttcaggcttt ccgccatcaa aaggaaacaa tgagagaatt 972241 tgaggaatta aatgaatcac atttttattt ccaaaacagg atgctgaatt taaactcctt 972301 aatgtcccat aatctggtca atgtcatccg caatcttgcg ttcgtctgtc tgatctggca 972361 ttttggcggt gcgagcctga atgcggcggg gattgtttct atcggtgtgc tgtacgcgtt 972421 tgtcgattat ttgaaccggt tatttcagcc gatcacaggc atcgtcaatc agttttcaaa 972481 gctggagctt gcaagggtct ccgccgggcg tgtttttgaa ctgcttgaag aaaagaatac 972541 ggaagaagcg ggtgaaccgg cgaaggagcg cgcgctgggg cgggttgaat ttcgtgatgt 972601 gtcatttgcg tatcaagaag gtgaagaggt attaaagcat atttccttta ctgcgcaaaa 972661 aggcgaaacc gtagcgctcg tcggccatac cggatcagga aaaagctcga ttttgaatct 972721 tctgtttcgt ttttatgatg cgcaaaaagg tgatgtctta attgatggaa aaagcattta 972781 caacatgtca agacaggaac tcagatccca tatgggtatt gtgcttcagg acccgtactt 972841 attctcgggc acaatcggat ctaacgtaag tctggatgac gaaagaatga ctgaagaaga 972901 aataaaaaat gcactgcggc aagtcggtgc tgagcctctt cttaagaagc ttccgaaggg 972961 cattaatgag cccgtgattg aaaaaggcag cacgctatcc tctggagagc ggcagttaat 973021 ttctttcgct agagctttgg cgtttgatcc cgcgatcttg attttagatg aggcaacggc 973081 gcatattgat acagagacag aggccgtgat ccagaaggcg cttgatgtcg tcaaacaagg 973141 acgcaccacc ttcgtcatcg ctcaccggct ttcaacaatc agaaatgctg atcagatttt 973201 ggttcttgat aaaggagaaa ttgttgagag agggaaccac gaggaactga tggcattaga 973261 aggccaatat tatcaaatgt atgaactgca aaagggacag aaacattcca ttgcataacg 973321 ctcaaaaacc caaaacaatc gtgttttggg tttttggttt atgtagtcaa taagccagtc 973381 cgacacggtt tccgacatac tcacctgtaa cgagctcacg atataaaaag tccgcagtat 973441 cgccgaccga aatgcttgtg ccgccctcag gcaaaacgtt acgctccgta cgataaacgc 973501 cggttgctgt tccgtccggg aggtaagtgg ggcagatgat tgtccagtct aatgatgatt 973561 ctttaagcat ttcgtatact tttgcatgct ccttggctgc gcgggtctgc tttcgtttcg 973621 attcatttgt ttcaaaccgg tattttcccg gttcatatcg ggaatctagg atccctgcgg 973681 tgccgatcgt aataagccgt ttgatatgct gttcctccat aacggagaga atgtgtgcca 973741 tagcagttga caaggtatca tcaccatctg tgcctagaca gctgatcacg atttcagcat 973801 tctccattat ttttttcaca tcttctaagc ggcgggcgtt ccccatgaca gttctgtctt 973861 ttgaaagggg aagatcagca tgttgagatc tgatcagagc gaaaatatca aatctttcat 973921 ctgctgcagc ttgtgttaaa aaggcttgtc cgacgcggcc gctggctcct aataaagcga 973981 ttttcattaa aaaacctcct cgcctttcat tataaaagga tgttctcagt ttgaacagcg 974041 cgggaaagaa tacctgtaca aataaacaga acgatgggaa acatattcat gaatcatgga 974101 tacacttacg aattgaacca gctcccaatt cacaatggtg atgaatgaca ccccgattcc 974161 ctcccttttt ttctaggata tgtggagcag gaaaaaaggg tgacaaaata aagagagcgc 974221 ggaaaccgcg ccctctatag ccatatattg aattgttatt gaactctgcc gcccatttgc 974281 tgctgagcga aagatactaa acgttttgtg atttctcctc cgacagaacc gttagcgcga 974341 gaagttgtgt ccgctccaag gttaacgccg aattcagaag cgatttcaag tttcatttga 974401 tcgatagcct gagctgcgcc aggaactagt aagtcatttg aagagttttg gttagccatg 974461 tgtaaaatct cctttttatt tagtatggtt gggttaactg gagttgcacc aatctgtgaa 974521 cccttctcgg gtgtcactgc cgcctcggcg taacccaatg ctttgccggc ttgttactac 974581 gtattatgtt aaaatggccg gaaaatcatg cggagaattg tgtggtaaat cttgagaaat 974641 aaaaaaagct tagccgttta ggctaagcta gtcataaata tgaaaaagca tcagttcatg 974701 tatctcgttt gtaagagcag gctcgtcagc gcgggcggga aacaagtctc cccattcaat 974761 ctcaccgctc ttatgataga tgccttcata atgggtccct ttataataaa atgaaatttt 974821 ccatccgggc agcttttctt ttgggaacaa aggtttccag ctgaaatgag aaatcattac 974881 ggccacgctc cttacatttg gtatcaattg acctaaataa aaacggctta tgttcattgt 974941 atcattgttt cagaacatca ttgaagaggc ctaaatatgc agtttgtccc agctttggat 975001 aaagataagc ccgctttatt aaaaaagcgg acaggttacg aaggccacaa tgcttccgga 975061 gatgtgattg ccttctcaga taaatatgac gcgtattcaa aacttcttcg ttttgtaaga 975121 gaatcaacat gatgcaaatt tggatgagaa aaaatgcttc ggcccgggcg cgaattcgct 975181 tcaaacatcc atactttacc gttctgatca atgccaaaat cgaaaccaat ctccccgata 975241 aatccctcga tatgatcatg aaggacatgg cttgcagtca gtgccgctgc agaaagcttt 975301 ttaatgacct caactctttc agcgggatca tcgtatactt ccgcaagtgt ctttacagtg 975361 ccgccgttag aaagatgtgt tgtaatgctg ttctttccgg aaatttttac ggcgattgct 975421 gtcactgtcc attttccttt tctgttttta ttggtatgga cacggaaatc cgctggtttg 975481 ccttgaaatt cgatgagatc aacaccttgc tgaatgagaa agtcggacgg gttgtgatgt 975541 ttttgaaatt ctgcaaggaa tgaggcggca tcggaataat caattgatgt aaaagttttg 975601 gcgtcattcg tatgctttac cgtcaggccg ccatctgttc ttgtcagctg ataaatgccg 975661 gtgccgagtg ctccatttgc cggtttgata tagacttttt tgtatgcgcc acagagctca 975721 tctatcagct ccacagacgg tgtcagctcg gatctaggca aaaagggtgc cgttcttgga 975781 tctttttcga gcaattgatg aacgttccat ttattgaaaa acgttttatt aaaccatggg 975841 atctgatatt catcgatcag cctctttttt gtatgttgca agagaagtga atcttcaatt 975901 tttcggttcg gcaaacggtc ataaacgacg ttcggcaatg gaacgatttt tttctcccag 975961 ccgttttccc tgtaaaggag gccttcaatc gtgccttcct cccaattgat ttggtgcgcg 976021 ccaaaaacga agcagtagcc cccggcttgc tcgtgtaacg tgacaagttt agaaaaaaag 976081 agggaacgat ccttaaatgg gcgttcaaga gatacagtaa accctgccgt aaagatgccg 976141 actaacggcc cgatatgcac tgtatgatca tgaatcagta tatctgccct gcttcggtgg 976201 ggaagcaaaa gctcatgaaa cagattttca gagagaagca cggtttgttc cagatgccgt 976261 ctgtaagcaa cgtggcatct gacaaccttc gttccgaatg cggcatgcaa aagtccgtct 976321 tgcttcagcg aagagggcag aaacagggtg ttttcactgg ttttgtctat gccgatcaaa 976381 aaccgtttag gattcacgcg gaagaactcc tttctggctt tgctcagaaa acagatattg 976441 gcagcgtttt aggggacaag tgtacagctg ttctttttgc tcgggagaga cacgcaggat 976501 tgacttcctg cctggtttgg aattgatatc taaaatccaa attctcccgt cctttgcaag 976561 acatatatca agaccgagtt caaacaacgg cccatagcgc tcgtcaagat aatacggaac 976621 cgattgggta attgaaaaca catcatctag taaaaccact tgctgttttt tcggtatatc 976681 ttcaaaccag gagtcaaatg tcagcgcatc agatccgcct gacaaattgg ccagcagccc 976741 gtgtttgtat ccgcgtctta ctgcctttcc gactgtattc cattcacctg cttcgttttt 976801 ttccataaac agacgaatat cacaagggta ttgttcctta tcttgaatgt ttaagtaagg 976861 ctgaagcaaa tattgatgct gaagcacttt tttgcaccat gttttaaaag aagtctggtt 976921 ggaaaacgtt tttgtctgct tatcctttcc gatgtgataa gtagcagtga tgtttttctt 976981 gcccagcttc aaaagaatca cgcctctgcc tcccgcgccg aatgccggtt taaggatgca 977041 ggctttttct ttggataaaa aggagtgaat ttgttcgtag cggctcacct ttatcgtttc 977101 gggaatatag ggattgatta cagagtgctg ctgcaaatcg tgaaggacgg tccacttatc 977161 gggaagaccc cgcccgataa attccgtttt cggatatttt ttgagccact caacgattgg 977221 ttttgctttt tgggaatgtg aatccttgcc gtaaaaacag cgatcataaa tataatctgg 977281 aatcgccatt tcagtttcgt tccatgtgct gctggccgaa tgatagaccg atgctttgac 977341 acgcaaagtg tcaggtgaaa tatcaaatgg tgtaaaccgg atgaaacgta tgccgaattc 977401 gggtgctctt ttggccagtt ctgcggaata atccgcttca tgctggcggg ataaggacat 977461 aaaaccgagt gttatcatgg tgagactccc ccttttattc aaaagctgcc ggcgggtgtc 977521 cgcagcttta cactaaatac atgtaagacg aacgcagctg acggtattct actttacaga 977581 atacgattct ccaccttgcc ctattccaaa agaacaagct gattttctaa gaacaggaat 977641 ttgtctcctc gtttgctaag tgattgcatg agcctctata atacgtatag gtacataatc 977701 tatatgaaaa aagctgaagc acagatggag gaagatgaat aggaatgggt attgcaggaa 977761 cctttatttt tatgatcgtg atcggcgctg ccattggagc ggtgaccaat catttagcaa 977821 ttcaaatgct gtttaggccg tataaagcgt actatttgtt tgggaaacga gttcctttta 977881 cgcccgggct gattccaaga cggcgagatg aacttgcaaa acaaatggga ctgatggtag 977941 tcaatcatct cttaacccct gaaggcatta aaaagcggct cgtctctgat gcagccaaaa 978001 cgcaggctct tcgagtgggg gaacagctga ttcaaaagct gtcactttct gaagtgacag 978061 taaaagaagc gcttgaaaaa gccgggatga agcgccccga aaaagctgct gatgcatgga 978121 tcagcagctg gaccgatgat aagctgcatg agcttttccg ccaatacggg gaccaatcgt 978181 taaaagagct ggtgcctata gaggtgcagg aaaagcttga ggaaaaaatt ccgatgattt 978241 caggatatat attgtcacgg agtgtccgtt attttgaaag tgatgaagga aaaatccgtc 978301 ttggcaatat gattgatgac tttttaaaag agcgcggcat gcttggaagc atggtgcaat 978361 tgtttcttgg caattcaagc cttgcggatc gcgtgctgcc ggagctgctg aaattcttgc 978421 gcaatgagga aacaaataaa ttgctttctg atctcttaaa aaacgaatgg ggcaagctga 978481 gggagtatac gtttaatgaa gcagatgaaa aatggaatgc aaaggcgctc attttcagtt 978541 tgaaacgaag agtgctgcaa gcattttcga ctgccccttt cttcaacaat acgattggca 978601 cgcttaccgt ccgctatgaa tctgagctga cccagcaaat gctgccggca ctattagaca 978661 aattgcttga aggtatttcg tccaaccttg aaagtgtctt aaaacggttg cgtcttgagg 978721 aaatcgtcaa ggagcaggtg gatcagttcc cggtggagcg tcttgaagaa atggtgctgt 978781 ccatttcaaa aaaagaattt aaaatgatta cctatttggg gggccttctc ggcggaatta 978841 taggcgcgat tcaagcattg tttgtcatcc ttttttaaga agaaatggtt tttgattaat 978901 gaaaggagct ccatagtctg ttatagtgga gtggtatgtc aaacggcaat gatgaaagga 978961 gctatttaca atggctgtta atttttatga tgtagcgtat gatctggaaa atgcattacg 979021 cgggagcgaa gaattcaccc gtttaaaaaa cctttacgac gaagttaacg cagatgaatc 979081 agcgaagcgc atgttcgaaa acttccgtga tgtacagctt agactccagc aaaaacaaat 979141 ggcaggagaa gagattacac aagaagaagt gacgcaggct caaaaaacag ttgcgcttgt 979201 acagcagcac gaaaaaattt ctcagctgat ggaagcggag cagcgcatga gcatgctgat 979261 tggtgaattg aacaaaatca ttatgaagcc tttagaagag ctttacggca gtgttgaagg 979321 ctaataagca aaatcccttc ttggataaga agggattttt tattcactca gcaaacttgg 979381 aaatccaatg aatcttttac ctctccattg atgatgactg ataatgtatg aattcctttg 979441 taatgctttc tggtggttaa atccttaaag gattggattc ttgtgtatga cttcgtttcg 979501 ttttttcgta tatttgtttc tgttatttta aatactttct gatgacgctg gcctcttgct 979561 tttacaaaat caattgcgta ctcaattctt actttttgat ccctgtctga atgaatatag 979621 aaagaaaatt caaggctttc gccaataact atacgtttgg gctggcatgt taaatcatgt 979681 agttgtatcg aatcagcatt ttcataacca aaaagcgcta aggcctgttt atcacccttt 979741 tttaataagg tccgataggc gtgtttgata atccagtctg tatggggatg tgttccgtac 979801 cattgatctg cgacttttct cagtaaatga ggatgcgttt ttgatatatc attaaggttg 979861 ttggccacgc tttttcttac atataaagac tcgtcctgca tcagcttctc aaggatcggc 979921 aatacggggg aagggtccga tttcaaagcc ggtatcgatt ttccccatgg caggcggggc 979981 ctgctgcctt cgctcgcaag tcttctcacg tgttcatttt tatgctcaga ccatgcaagc 980041 aattgtgcaa tcatcttttc ttgatctaac agcaaaaaag gccttacagc aaattctgag 980101 gtcgaatatt gcgtaaagga ttccaatgcc tttattgatt cttcccaatg cgctaacccg 980161 tactgttcca cataatctgg aaataaaatt ccgctgagtc ctttaaaatg aggggctgta 980221 tcccgtaaaa ttgtgagcgc ttcaacgtat tgttttggca aagtttcgta taaagaaact 980281 gtcacgcggc gcatccgctc ttttaaagtg agttcaggcc agtcctccag ccgtaatgta 980341 tccaagaatc tgtttttgtt aaaatcagga taggatgacc ttacatgatg gatcaactga 980401 gatatcagtt cttcattata tatttctttt aaatcagcca tataaacacc gctttttcgt 980461 ttattattta tattgtatgg gaatgtacgt tctggatcaa gtgtatagtc ctaaaaatta 980521 acaactgatc ctaccacgga tatacaaaag ttggttactt tttttagtta aaaaaaccct 980581 tgtcatcgga aaggaaaact gagataataa cattgaaagc gcctacactt acctatttca 980641 aatggatacg gtcgcatatc atgccgttat atagagggga taagcaacag agagtaagtg 980701 ttcggagcgc atcattggtc aaacaagggg ttcctgatac atgatttttc gtaaatcgaa 980761 ataacgatat tagggagaat ggctgcttcg atcgtatcct atcaacaagc catacataaa 980821 gtctgctgag ccaggctttt tttgctttaa gaaaaggttg ttctaaacac agagacaggg 980881 tcatatccta tacacaagta cagtcatcaa ggagggggac atctctgtgt caaaacaatt 980941 gcttgcctta aatatagatg gagcgctgct tcggtcgaac gggaagattc atcaggcaac 981001 gaaagacgcg attgaatatg taaagaaaaa agggatttac gtcacacttg tgaccaaccg 981061 tcattttcgc tcagcacaga aaatagcgaa atcgctaaag cttgatgcca agctgatcac 981121 ccatagcggg gcatatatcg ctgagaaaat tgacgccccg ttttttgaaa aaagaatttc 981181 tgatgatcat acctttaaca ttgttcaagt gctggagagc tatcaatgca atattcggct 981241 tcttcacgaa aagtattcca tcggaaacaa gaaaaaggtg aattcgaatt tattagggaa 981301 agcactcatt catccgtctg acccgatctt ttatccagtc cagttcgttg aatcattaag 981361 cgatctcctc atggatgagc cggtgagtgc acccgtcatc gaggtgtaca cggagcacga 981421 cattcagcat gacattacag aaacgattac aaaagccttc cctgcggtgg acgtgattcg 981481 cgtaaacgat gagaaactga atatcgtccc gaagggtgtc tcgaaggaag cgggtttggc 981541 cctcgtcgct tcagagctgg gcctgagtat ggatgatgtc gtggccattg ggcatcagta 981601 tgacgatctg ccgatgatcg aacttgccgg tcttggggta gcgatgggga atgccgttcc 981661 ggaaattaag agaaaggcag attgggttac aaggtccaat gacgagcaag gtgtcgctta 981721 tatgatgaag gaatatttcc gaatgcagca gcgaaaagga tttcttgata agttccacat 981781 gaaacgtgtg taaaaaagcc gctcgcgccc tgacaggtgc ggcggctttt ttgccggatt 981841 gattttagca gtttatttct gtacactaaa gaaagttttg aatctgataa attaggtgat 981901 gaagttgcaa attaaaatag aaggcataca tgatgaccgc ctgcatcggc ctctgcaaaa 981961 tattgcaaat ttgttttatg aagagtgcga gcttgcgtat ggcggagagg agcccgcaga 982021 ttttgtcatt tctttagcgt tgtcacaaac ggatgagcat gtgacggttt ctggagaagt 982081 gaagggtact ggcataaagg aacagcatac aaaattcttt tctccagaca tgactgaaaa 982141 agaagctttt aagcaagtga aaaacacaat ttcttatgtg tatctcaatc ttcttcaggc 982201 gcatacgggc attacgcaga agtggggaat cctcacagga atccggccca caaagctgct 982261 tcataaaaaa ctgcaaagcg gaatgtccaa ggagcaagcg catgctgagt tgaaaaaaga 982321 ctatttaatt catgatgaaa aaatcatgct aatgcaggaa attgttgacc gtcagctggc 982381 ggcagtgccg gatttgtacc gagtaaagga tgaagtcagc atttatatcg gcattccgtt 982441 ctgcccgaca aaatgcgcgt attgcacatt ccctgcgtac gctatccaag gacaggcggg 982501 cagagtcggc tcattcctat ggggactgca ttacgaaatg cagaaaatcg gtgaatggct 982561 gaaggagcat gatgttaagg ttacaaccat ttactttggc ggcgggacgc cgacaagcat 982621 tacagcggag gagatggatc tgctgtatga agaaatggtc cgctccttcc cggatgtgaa 982681 aaacattcgt gagattacgg tggaggccgg tcgtcctgac acgattacag aagaaaaact 982741 cgccgtttta aacaaatatg acattgatcg gatcagcatc aatccgcaat cctacgaaaa 982801 cgaaacgcta aaggcgatcg ggcggcacca tacggttgaa gagaccattg agaaatatca 982861 tctgtcacgc cagcacggca tgaataatat taacatggac ttgattattg gtttgcctgg 982921 ggaaggcgtg aaggagttca ggcacagtct ttcagaaaca gaaaaactga tgccggaatc 982981 ccttaccgtt catactcttt catttaaacg ggcgtcagaa atgacgagaa acaagcataa 983041 gtacaaagtt gccggcaggg aagaggtttc tcaaatgatg gaagacgcgg tagcctggac 983101 gaaagagcat gggtacgtgc cttattattt ataccgccag aaaaacattc ttggaaacct 983161 tgaaaacgtc ggatactctt tgccgggaca agaaagcatc tacaacatta tgattatgga 983221 agaggtgcag acgattattg gcatcggctg cggcgctgct agtaaattta ttgatcggga 983281 tacagggaaa attacgcatt ttgcgaatcc gaaagatccg aaatcgtaca atgagcgctt 983341 cgagcactac acggacgaaa aaatcaaata tttagagcag atttttgaaa aaacgacaaa 983401 gcagcactga ttacagtgct gcttttttta tccctgtttt tttgcgggct gaacctcagg 983461 cttccattta aataccttgt tcagcaagcg gtaaattcgt tttgattcct ttgtgacaag 983521 cggtcccaaa atcgccagaa tgaggacata taatgcggca aacggcttta atgtggccga 983581 cagtccgccg gctatcccga gattcgcaac gataatcgaa aattctcccc gcgatacgat 983641 cgtcagcccg atattcgatg aagccttatg agaaagccct gcgcgtcgtc ctgccaccat 983701 tccggcgata aaatttccca gaatggtcaa aatcactgca cccaacgcaa gccaaaccgc 983761 ttcaccaagc gaaaacggat cgatgctgag gccgaagctg aaaaagaaca tcgcaccgaa 983821 gaagtcgcga aacggaacaa cgaggtgttc aatcctatcg gaatgctctg tttctgaaaa 983881 gaccaaaccg agcagcagcg cgccgattgc ttctgctaca tgaatcgtct ctgaaaaacc 983941 ggcgataaaa aagagtgctg cgaaaatgac gataataaac acttcgtttg agcgaatgtc 984001 caacagtttg ttcaacagcg gcgggagttt tcttgctgcg ataaaaaaca gcagcatata 984061 accgaaggcg atcaaaatgg acaagagtgc actccctacg gatgtcgcat cacctagtat 984121 aaggccggaa acaacggaca gatatacggc aaggaaaata tcttcaaaca tgatgatgcc 984181 gagaatcaat tcggtttccg ggttggcggt tctttttaaa tcaacgagca cttttgcgac 984241 aatcgcactt gacgagattg tgatgacgcc tgcgaggatg aggacttcca gaaaggaaaa 984301 tccggtgata aacccgtaaa gcagtccgag gctgaagtta atcaaaatat aaatcgtccc 984361 gccgaccgcg attgattttc ctgatttgat taacttcccg acagagaatt cgagtccgag 984421 atagaagagg aggaacagta cgcccattcg cccgaaaaac tcgatgattt cactgctttg 984481 aataaatgtt agatcaataa tccccatttt cggcgcgtgc ggtccaacaa gcattcccag 984541 cacaatcaga aacggaataa tcgaaaattt aattttattg gcgatcacac tggcgattgc 984601 cacaagcaca agtgcagttc cgacttcaaa tacaagatgg tccatcgggg ctcacacgcc 984661 ctctccagaa agaaaatcgt gaatcagttt cttcagatgc tttctctcac ctgagaggac 984721 aagggtgtca ttttcttcaa taatcgaatc cgctccggga tttaggagct tttcctggtt 984781 gtgtttgata atcgcaataa cagtgacatc gtaattctgg cgaacatcaa gctcaccgag 984841 tgtgcgtccg atcgatttgg cgcctttttc gaccttaaac cattcaataa taagatcgct 984901 gaaggccatt tcgatggact ccagagcttg cggtttatag accatgcccc cgagaatagc 984961 tgcaatttgc cttgcttcag aatcatccaa tgaaatattt gaaagaagct catccgggtc 985021 ccggtcatta aaccggtaaa tttcccttct tccgtcatca tgaatgataa tcgtcatttt 985081 ttcgtggctt cttgtttcga tttcaaactt tttgccgatg cccggcagat cgttttcttt 985141 aatattcaat gaaaatccct ccgaatgtag tgttggcagt atggggtgag ttacaaataa 985201 aacttgagca aattatattc ggaggtaatt agactggtat ttgacaggga cggccaaagc 985261 cttttccagc ctgtttatca gcggttcgtc aagtggtttg acagagagct gcctgacaga 985321 ctgcgccagc gggctgtact ctttgatcag ctcagccggg tgcatgctgc ccggcgatgg 985381 cgtttttgcc gattgtgttt cctgcggata tgaagacata ggcacatagc tgtcagtgct 985441 tgcttcaaac tgggaaggca gaaccacgtc cgaaggggga aagtacacca taaataaact 985501 taacagaaaa ctgatcagca atttatccat gttcctttcc tcccttctca tcaagatatc 985561 ccttcttttt cactatataa aactttatgt ttccattcaa acaatatgca tttttcagta 985621 tctattgacc ttgaaaaata aaaaggttta tttggggatg gcggggaatg tataggagaa 985681 agaaaaaagt aagcgcatac atggaggtgc ttttaatgga gtttgttcaa tatgcatgta 985741 atggggccgt tgcagagatt atcctgaatc ggcctgatgc ccatcacgcc ctgaatgaac 985801 agatgctgtc tgaattgaag gaggcagtcg aaatggcggc tgcaagcgag gcgctcatcg 985861 ttctcctgag aggaagcggg aaaggctttt cggccggcgg tgatatcagg atgatgacgt 985921 cagagcatga ccctgaccaa tttaaacggc tgatggatac gattgaggct gtcaccctga 985981 atttatatca gatgaagaaa gtgacaattg cagccattca tggtgctgct gcgggactgg 986041 gcctgagttt ggcgctttgt gcggacattg tgctcgctga aaaaaacgcc gttctcgcga 986101 tgaattttat cggcattggg cttgttccgg acggcggagg acattatttg ctgaagaaaa 986161 gaatcggtga agcaaaagcg aaaaaactga tttggagcgg aaaaaaacta tctgcctcgg 986221 aagctgccga tatggggctt cttgatggga catttgccgg agaccctgcc gaaggcgcaa 986281 gacccattat cgaaaccctg ttggcctccc ctcttttggc gatgatcgaa acgaaaggta 986341 tttttcaaag cctccaaatt gaagaactga aaaaagtgct atcccttgag cgcagcgccc 986401 aagagagaat gagaaggacc aaggatcacc aagaaggaat ccgtgccttt ttagaaaaac 986461 gggagccgaa gtttcaagcg taacagatca gccggaaagc tgatcatctg tgaaacaaaa 986521 tcagctttcc ggctgcattg actaaacgat gagtatgact atgaagctct ttttctttta 986581 agagggcttc accatgcgtt tttgccgctt cttcatgttc tgcctcgaat tgctcgttta 986641 ccagcgtgtt ccccgaagga tcaaatacgg taaggaaata atcagccatc aggtttctcc 986701 tccattttaa ggtttatcag tctttcttca tttatattct aaaaaggaaa tcaaaatcct 986761 ttattatgct ttatccaaaa ttagtatata atgggtcagg gaaggaggag attcagtgct 986821 tacaattgat cacgtaacga agacatttgg agattataaa gccgttgacg gattggactt 986881 agatattccg gaacagcaaa tgttcggtct attaggcgca aacggagcgg gaaaaacaac 986941 aacgtttcgc atgatcctag gattattaag cattacggag ggctcaatca gctggaaggg 987001 ccgtcctgtg aattatcata tcagcaacaa aatcggttat ttgccggaag agcggggcct 987061 ttatccgaaa atgaaggtaa gggatcagct cgtctatctt gccagattaa aagggatgga 987121 gaagcgagag gctgtaaaag agctcgggac atggcttgaa cgcttcaata ttacagatta 987181 cgagaataag aaggtggaag agctttcgaa ggggaatcag cagaaaatcc aattcatttc 987241 ggcagttttg cataagccgg agctcctgat tcttgatgaa ccattcagcg gcttggaccc 987301 tgtcaatgtt gagctgctaa aagaggccgt gatctcgctg aaaaacagcg gtgtttctat 987361 tttattttca agccatcgga tggaacatgt ggaggagctt tgtgagaacc tttgcatatt 987421 gcagaaagga aaaccggttg tacaaggcaa gctgaaggag atcaagcgtt ctttcggtaa 987481 aaagaatgtt accattcact ccgatgacga tctgcgcttt ttgcagtccc atgaaggcat 987541 tcttcaatgg aaggaaacgg cagacggcgt caagctgcag attgccaatg aagacatttc 987601 tcaagagatt tttgcgatgc tccaaggaaa agggtttatc agaaagtttg agcttgaaga 987661 gccgtcactg catgatattt ttatagaaaa ggtgggggcc gtctatgaat aaattttgga 987721 tcatgctttc tcatacatac aaaaataaga ttatggcaaa atcctttatt atttcgactg 987781 tcatcacggt gctgcttgtt ttagttgtaa cgaatctgga gtcgatcatt tctttgtttc 987841 aaggtgacga tgcgaaagaa aaaatcgccg ttgttgatga aacaaacgaa ttatatccgg 987901 ttttttctaa gcagctgaaa gcggtggata cagacggcga tcttgatgtg aagctgtcga 987961 agcaatcgga ggatgaggtc acaaagcaag tcaaagatga atcactcgat ggcatgctca 988021 tcatcaaacg agatgaaaaa gggaccattt caggaacata taaagcgtta acgatttctg 988081 atgaaagcac gtatcaaaca ctgcagcagg cgctgacgca aaccaaaaca gctgtcggaa 988141 cagcggagct cggcgtgtcg caggaaacga ttagcagcct ttatgcgcct gttactgtgg 988201 ggcagaaggc gctgaaagaa ggggcaaagt ctgaggaaga gcttggccag acggtagggc 988261 ttgtttacat tatgctgttc gtcatttatt tctcggtgat tatgtatgcc agcatgatag 988321 cgatggaggt cgcaaccgaa aaatcttcgc gagttatgga aatcctgatc tcaagtatgc 988381 cgccgatcca gcaaatgttt gcaaagctgc ttggtatcgg gcttgtcggg atcacacagc 988441 ttgctattat tataggagcc ggctctctgt cgcttaagct gaaccaaaag agcgaaacgg 988501 cttcatctgt cggcggattc cttaatttga ccgacgtatc tgcaaccact gtcatctatg 988561 ctgtcatttt ctttttgctc ggatactttt tgtacgcgac acttgccgcg tttctcggca 988621 gtgtcgtcag cagaatagag gacgtgcagc aaacgatcac gccgatgacg cttttggttg 988681 tcgccggttt tatgatcgcg atgttcggtt tgaatgcgcc tgacgcagga tttattacgg 988741 taacttcgtt tattccgttc tttacgccaa tgattatgtt cctgcgcgtc ggcatgcttg 988801 atattccgtt ctggcaggcg gctgtcggaa tcggaatcac actgctcacc attgtcatac 988861 tggccgttat cggcgccaga atttataaag gcggtgtatt aatttacggc aattcaagcg 988921 cgttcaaagc gatcaaacaa gcgctacgtt tagcgaaaaa ctgattggaa aacagcctgg 988981 ggattctcag gctgtttctt tattgacaga acgtgcattc gcaagaattc ggtgctaaaa 989041 taagggtact tcatcctgga aaggagcaga atgttgactg atctaacctt tattcatgcg 989101 gcagatcttc atcttgacag cccgttttac gggatatcgc atctgccgga gccgattttt 989161 gcccggatta aagaaagcac gtttgcaagc gtgagacata tgatagacgc cgcagtgaga 989221 gagcacgttg atttcatttt gcttgcggga gatctgtttg atgaagccaa tcgaagctta 989281 aaggctcagc tctttttgaa aaaacagttt gaaagactca gagagtgcgg aatttcggta 989341 tacgtcatct ttgggaatca cgatcatctt ggcggggagt ggacgccgat tgaatggcct 989401 gagaatgtcc atattttttc gtccgctgtt ccagaagaaa aatcgttttt taaagaaggc 989461 aggcgcatag caagcattta cggcttcagc tatcaagcca gagcattgat ggaaaaccaa 989521 gccgcccgct atcggagatc aactgacgca ccgtttcata tcggcatgct ccacggcacg 989581 ctgtcaggat ctgaaggaca cgatccgtat tgcccgttta cacatgacga cctcgtgaaa 989641 agcgggatgg attattgggc gcttggccat atacataaac gccaggttct atctgccgag 989701 catccggcag tcatttaccc gggaaacacg caagcacgcc atataaagga gacgggagat 989761 aaaggctatt atctcgttca tgtgacaaac ggagatatat cttatgaatt tcagagagcg 989821 catgatgtcc tgtgggaaaa agcggcggtt gatgtgacgg aggcaaagaa tatgacagcc 989881 ctcttccaaa tggtggagga cacgttttcg aagctgcgga aaaaggggag ccctgtttgt 989941 gtaaggcttg ttttacaagg gacggcgccg gaatggctgc tggaggcgcc aaaaggcacc 990001 ttggatgagt ttcttgaagc tcttcaggaa caagaagcgg aagaggaacg tttcgtttgg 990061 cctcttagat tggacgatga gacagaaaac gaagcaaacc taacaaacct tgatcctttt 990121 tttggcggtt tatttgaaga cattgatcgc agcgatctgt cagacgtgct ggaagggctt 990181 gagcggcatc cagtgtatag aaggcacgcg gaccggttta gccaagagga ggtaaaggaa 990241 ataaaagagc aggcacagat aatattgaaa agacagctta aggtgcttga tacatgaggc 990301 ggtgacagct ttgcgaatta tatctttaca tatctaccaa tacggaaaat tttccaatcg 990361 gacctttgac ttttccgcct ctcctgtcca agtcatctac ggattaaatg aggcaggaaa 990421 aacgacgatg atgtcattca ttgaaagcat gctgttcggt tttccgaaaa cgaaaaagta 990481 tgaaccgaaa acaggcggtg tctacggcgg tgttcttgaa gctgaacatc ctgagtatgg 990541 ggtgctgaag atcgaacgga cgaaagggac tgccgaaaaa ctaagcgtgt acacagaaaa 990601 gggcgaagta aagcagggag atgttttaaa gcagctgttc cagggcacag acaggtcgtt 990661 gtacaaagcc atatattcgt tcgacgtatt cgggctgcag gaaattcacg cctttaatcg 990721 ggacaagata ggggaatttt tgctcttttc cagcttgttt ggtgctgaag ccgtatcaaa 990781 gcttgattca aggctgacga aggaaagcga aaggctctat aaaccaaatg ggcgaaaccc 990841 tcaattgaat caggagctgg aaacgcttaa gcagctggca gttaagctaa aacaggctga 990901 agcagaggaa gcgggctatc atcagcttct cgaggaaaaa cgaacgcttg aagcccgcct 990961 tgcagccgcg gaaaccgaat tgaaagagac ggcgggacat atccgaatga ttgagggagc 991021 gattgagcga aagccgctgc taaatgaaaa agcgacactc gaacaggtga ttgcagaatt 991081 tccggaacac gcaggacaat ttcctgctga cggactgcat cagctggaaa aatatgaatc 991141 ccatcttcac ccgaaatcag cacagcttga ggcgcttcgg gtgaagatgg cggagttgga 991201 caaacagagg caaaagctta tccccgataa agaactattg gcgaaagaaa cgctgataca 991261 agagctttcg gcagcgtttc atatgtacca atcctgggga gaacagctgg cagccattca 991321 ggcacagctg cgccagacgt ctgcgcagac agcggcaggg ctggaacagc tcaataaaac 991381 ggatgaaaat gagctcctga atatgaacac ctcatatgat tatgaatggc agcttcagca 991441 agcggtgcag caatatgtac aggcaagaga cagaaaacgg cagcttgacg agacgtttga 991501 acttgcccgg caagagctgg aagacgcgga aaaggccgtt cgtgccgctt cgtccgcgat 991561 tcttgaaaac agccaaagaa aagataaaga agcagctctt agagcatatg atgaaacaca 991621 ggggcagcac caagagcaag cgaagctcag agaacagcta acgttttttg aaagacagca 991681 ggctaaacag aaaaagactg tcattgcagc tggtatgttg ttcatcgttc tcttttctct 991741 gctgcagcaa tggattcccg ccataagttt cggcgctgca cttattgtgt attggcttgt 991801 ttcaggaaag tcgtcttctc gaaacagccg agagacaaga cagcccatga cggatatttc 991861 accagcagaa gctgaaatgc ttagagaagc gttatgggag gatgaccgca ataagcagca 991921 ccttctcaca cagcgtgcag cgctccagca aaaagaggcg gcgtatgaaa gggtcatcca 991981 gcagtttgaa cagtgggaag ccgaaatggc gccgtccttt acacaggttg agcgttttat 992041 gaatgagctc ggatttaagg aagatccatc atttttgctt gatgcataca gcttaatgaa 992101 ggatgttaaa aaagaagtga agaaaaagca tgagctgacc atagaagcag gcaggctgaa 992161 aaagcaccgg agaacattcg aagaacgcgt cagtatgctt cttcccgtga atcagagtca 992221 ggatatctcc atttcggacg cccttcacac attgcggaaa aacattgaac gtgaaaaaga 992281 aattgagaag caaaaaaagg aaattgaaac agatattcat tatacaaagg aacagatgct 992341 tgaacttgag caagaaatac agtatttcca cgcacagatt gaacagttat ttgccgcggc 992401 tgctgcaaaa gacagagatg cgttttttgc catagccgcc atcagcaggc aattgaagga 992461 tacggagaac aagcttcatc acgtaaacgc acagcttcaa ggcgggtacc cggaggaact 992521 tgaactggcg gattccaata cgctttctga attgaaagat aagcaatttg ttgagaatga 992581 aagaaaagag cggctgactg aggagatcga gcagctccgc agccaaatcg cactgctctc 992641 agtcaaacag gaacaattag aggcttcggg aatggtctca gacctcaagc ttcaaaccga 992701 aatgcaaaaa gaacgtgtga aagaaacggc taaaaaatgg gcctccatac aaatggtcaa 992761 acaggtgatc agaaacaaat tggagcggca taaaaaaatc gagcttccgc gccttctgga 992821 gacggcagga gaatttttcc gtcctctgac tgacggaaac taccaaacca tttatttttc 992881 cgaaacggat gattcgatca tggttatgca tcgcgatggc actgtctatc atgcggaaga 992941 gctgtcacaa gggacgtgtg aacagctgta tacagcgatc cgctttgctt tggccgttac 993001 gcgccagggt gagtcaaagc ttccgttcca gcttgacgac agttttgttc attttgatca 993061 ggaaaggctg aaacgtgtat tacatgttct gtatgattta tctgaaggcg gtaggcagat 993121 tttgtatttt acatgccatg agcacgtaaa agatgcattt catagcagcc aaatcatcca 993181 tttggtgtca taaaagaggt tctatagctg aaaatcggta tgtgatatac tggtattatg 993241 taagatacgg agggagcttt aatagaatgg ctaaagggat tatgctacat gaggttggcg 993301 aacaggtgga ccagtatcta ttgattaaat cctcgacgaa agggattgca agcaatggaa 993361 aaccgtttct gacgctgatg ctgcaagacc agtcaggcga tattgaagcg aagctgtggg 993421 atgccaagca aagtgatgaa gtgacctatg cgccgcagac gattgtcaag gtcgtcggcg 993481 atgttcacca ttatcgcgga cgcacccagc tgaagctaag aaatatcaga ccggtaagcg 993541 agcaagaaaa cgtcaatatt gatgattttt tagaaaccgc gccgattccg aaaaatgaaa 993601 tgatggatac catcactcaa tatatatttg aaatgaaaaa tccgaatatc cagcgaatca 993661 caaggttttt ggttaaaaaa cacgaagctg agtttatgga ttatccggcg gctacgaaaa 993721 accaccatga gtttgtctca ggtttggcgt atcatgttgt ctctatgctg aacctggcga 993781 aagcaatagc agatttatat ccttctcttg atcgtgatct gctttacgcc ggtgttatcc 993841 tgcatgatct tggaaaagtg aaggagctgt ccggccctgt ttccacttca tatacggttg 993901 aaggcaattt gctcggccat atttccatca tggtgacaga gctttcaaaa gcggctgagg 993961 agcttcaaat cgattctgaa gaggtgttaa ttcttcagca tttgattttg agtcaccacg 994021 gcaaagcaga atggggcagc ccgaaaccgc ctatggtgaa agaagcggaa attcttcact 994081 atatagacaa tctggatgca aaaatgaata tgatggacag agcgcttgag cgcgtgaagc 994141 cgggcgagta tactgaacgt gtatttgcac tggaaaaccg ttccttttat aaaccgacat 994201 ttcataaata acttaaaaag gactgatgct gacatattca gctcagtcct ttttgatgcg 994261 tctttcccgc acataactcg tctcattccc gcatatggtt aagaataaag aatctatgca 994321 aagggggagg agcccgtgtt attttttccg tggtgggtgt atctttgtat tgtaggcatc 994381 attttcagcg catataaact tgtggcggca gccaaagagg aagaaaaagt agaccaggct 994441 tttattgaaa aagaaggaca gatttatatg gagaggatgg aaaaggagcg agaacgccgc 994501 agttctcagc agcatgaaga agaaaatcaa aaccattcca tcgcataaaa aaagctgtgc 994561 ggctcaatga gccgcacagc tttttttatt atttagaatt gcttgaagat gaagaagtgc 994621 tgttgcttgt tgaagatgta ttaaatgtgt ctttcagatc tttatctttt acttcgatgt 994681 cagccttctt catgactttt tgaacagctt cctgaacagc tgcgttgtca tttaattttt 994741 gttcaagcac ttcagatttc agttcttttt tcatatcatc atatttgccg cgttcttctg 994801 tctttttaat gatatggtag ccgtattgcg ttttgacagg atcactgact tcacctgttt 994861 ttaatttgaa tgcagctttg ctgaatgttt cgtccatttg gccttctttt gcgaaccagc 994921 caagatcccc gccttttgaa gcagagctgt ctgttgagta ttctttcgca aggtcttcaa 994981 acttctcgcc ttttttcagc tttttctcta cttcttcagc tgtcttttta tcagcaacaa 995041 ggatgtggct tgcacggatt ttgcctttta agccttccca gtactctttg atatcggcgt 995101 ctgttacttt gatgttatct ttagccgctt tttgtgtcag caattcatat tttacttgtt 995161 ctttcaggta atctttgcca tattgctttt cgagggcagt atattgatcg ccaagctgcg 995221 ttttgtattc tttcagcttg ttgtcaattt ctttatccga aactttatac ttcttgtcca 995281 atactttttc ttgcactagc tgtgtcagta cgcttgcgcc agctgttttc ttcatgtttg 995341 tgtaaagctc gccttttgtg acatcgcctg cgtctgtttt tgcgataact tctttgtcgc 995401 cgctgctgca agcactgaga gcgaggatgc ttgtagcagt gatagctgct attgcgattt 995461 tcttcattgt tttcaaacac tcctaatcat tccaaattaa attacctatg cgtatcataa 995521 catattgtgg ctttctgtaa aaagatttta aataaagggc attcgtctag tcaaactttt 995581 gctgatgaca tacttatata ttgatcaaga aaaggaggta tgtaacatga gcggaggata 995641 ctctaacgga ttcgcgttgc tcgtagtact gttcattttg cttatcatcg taggtgcagc 995701 ttacatctac taagcagccc gaggatcgct tgcaacataa gcgatccttt attttcacta 995761 gcgcctaatc gtttcaaaca tgaattgcat aacatgtaat tggtaaataa agcttattac 995821 aggaggtgct atttaagatg ggtgaagtat ttgcaggcgg attcgcttta ttggttgtgt 995881 tatttatttt attgattatc atcggcgctt cttggctgta ctaatcaaca taaaaaagca 995941 tagctgctta atcagcagct atgctttctt tcgtatttac actgtaaagg agatctccac 996001 aaacgaagag atcagtaaaa ttaatataga tacattaata aatcggaata ccttatcttg 996061 ccgctcttca ggaatctctc tgacaaggca taatgtattg gtgagcctgt ttatgaaata 996121 taaaataaac acggcagcca cgataaaata gaataaaatg atgggagatt ccccctctct 996181 ctgaactgtc ccatattaca ttaccaaata tttattaaaa aagatagaat gcaaattgaa 996241 aaatcgccac cagcaccagg gtttgactac ttttcaacaa gaatatccaa gccgtcagct 996301 tcctgatcaa taaaagcggt tttcggtgct tttatcagct tgagagccag caggaaatca 996361 ggcagacagt agccggcgtg aatgcccgag atcatgcaaa aataatgagc gtgattcgga 996421 aatgccagtg ctgcgtaaaa caataccggt gtaatcagca agaacgggct gacgagtgaa 996481 atcagcattg ttgtttttgg tatacgtttc catgtgcgca tgcgcaatat gtaaaacttt 996541 ttttctattt ttcttttttt gcagatgatt ggcaggacat ggatgacttt atgtacaaat 996601 aaaataacga cgagcaaacc gccgaataaa gatacatatt catcgcttaa gcttgtgcca 996661 ggccgcagca gctcaaaagc taaaaaggta gatataaaaa ccaaaatcat aaaacataca 996721 gcagttaata ttatgcgaac ggcgccataa tccttcatga gatttatggt cttccagcaa 996781 ttcatcaaag tcatccttcc atacatcttg aatagaatct caaaataatt tactcctccc 996841 aagagaaaaa atcaatgctt ttttaagaaa aaatatcatc cggcaggtat ttttttgaaa 996901 caagcaaaca aactgcgaaa tatggggtta gaactttctt ctcagtgaat tatcagctaa 996961 aataagatta aagatagaaa gaagtggtgt ggatggattc gatggatcat cgcattgagc 997021 gattagaata ttacatacaa ttattagtga aaacagtaga tatggacagg taccccttct 997081 atgcgcttct cattgataaa gggctgagca aggaagaagg ggaagcggtt atgaggatat 997141 gcgacgaatt gtcggaagag ctggcaacac aaaaagcgca aggatttgta acctttgata 997201 agctccttgc gctttttgcc ggacagctga atgaaaaatt agatgttcat gaaacaattt 997261 ttgccctgta tgagcagggg ctttatcaag agctgatgga agtctttatc gacatcatga 997321 agcattttga ttaactgttt acaggttcga gctcttcagc cggttcatcc gccgcactgt 997381 cctttgcttt tttcttcaat tttccgttta cgctttcaaa gtcattgtca atattggtga 997441 gtgacgtttc gaaaatttcc ataaaatcat cgccgtagat atggcgtatc atacacatca 997501 tttctgccac ttcaggaaat tttccgaata aatgatataa aggctgtgac cctttaaaaa 997561 cagcgttgcg tgtcggatca aattcctcaa gcaagctcca gaatacctcg gtaccttcct 997621 cagtcaattg gacatatgtg ttccgtttat cattcagccg tttggagaac cttaaatatc 997681 cccgttcttc cagctttttt gaaaagttga atgcggttga tacgtgcatg accccgaatt 997741 tcgcgatttc agaaatggaa gctccattca attgatacgc aatccataaa atatgatgct 997801 cattaatatt caggtcatac ggtttgagcc attgctgcca atccttctcg atcgatttcc 997861 aaagagcctt gctaagctga gccattttct gggtgaaaac cagagcttct ttcacatcat 997921 agggcggttc cactcgattc attacgtcac ctgcttctct ttttcttttt ctctattatg 997981 ccaataaaat aaagattaat aaagatgaaa atgtaagaat tttttaataa attcacaaac 998041 cattgcgacg aaagggtttt tcggccaaaa aaaatacggg tccaattttg gcccgcattt 998101 ttttcttttg aataggatat tagttttgta aggttttctc cagctgtctg attttctctt 998161 cgatatcggc aatttctttt tgcagatcct gctggtgagg cttgatctct tcctgccatt 998221 ttttaattga tgtttggagc tcgccgccca cgtctttaat aacatccgtg ctttcttttg 998281 ccgctttgat cagctggtct tttaatgcaa gcccgtctga ctttaagcgt ttgattgttt 998341 cttcaaaaga atcataattg gttttcattt tttcacgcag ctgctttcct gaggaaggtg 998401 cagtaagaag aaccgctgct cctccgatga tgccgcctac gaatagtcct gttaatagag 998461 aacgtccgct cgccattaca atcaccccgt ctttttcttc aaaataggat tcattcagca 998521 tttttcattt ttgttgaaag cctgaacttc tatacatagc ttgctttatt ttagcatatt 998581 ttttaagtga aaaggaggga gaaggttgtc tgtctttttg attgtattat cctgcatcac 998641 ccttgccttc gcttcaggcg ctgtttacta tatcaaactt ctcagccagg ctgcttctta 998701 tccgcccaag agggttatcc ggcagaaagc gcttgtttgt tcaaccggaa ccgcctttac 998761 actatgtctt atctttttca caaaactcct cgcttaaaac atgctgacat gctgcgggcg 998821 ctctgttcaa aaaaacctct cccggaagcg gaagaggttt tgtgtgacaa ttatttagca 998881 gcttccataa agcttgaacg ccttaaaatg gtttgcacaa tcggataaat aatgatcatt 998941 gagattgtat tcagcacagc ggccggcaga acaacagccg cgaacaatgc ggcgaaaccg 999001 cccggtaaac cgacgatcaa taaagctgac gatagaaaca caattcctga taagatggtc 999061 ccgatcactg tcagcacagc ggctgcacct gttttccggc tctttctgaa caagagaaac 999121 agggagaaga acagaaacgc tgatacgggt ttatcaatga tgttagggat ctgtccggct 999181 ggaaacgcgg ttgtaagcgc ggaaatgatt ccggtcacga tcccgatgac gagtacattt 999241 tgcacccgcg ggaacagcag aatgcccatg aacatcatga tcagcatcat atctggtttc 999301 atgccgccta aaaagggcgg aataatggaa tgaagcgctg cgccgattgc ggcaaacaga 999361 gccataatga ctaactcttt tgttttcata actatgctct cctctgctaa gctttttgcc 999421 ctccaataat atgctcatca tttattgcga aggctttaca gaatgtgtta tgcaaacagt 999481 ataccaaacg gacggtttgc atagccagac tttttactca ttttcctgct ggaatttctt 999541 catgaacgca gctaattttt cacagtcttc gagagagacc gcgttataaa tagaagcgcg 999601 gcagcctccc accgaacggt gtccgccaag gccgatcatc ttcgcatctt ttgctttctg 999661 aacgaatgtt ttcgttaatt cgtcatcccg aagcgtgaat gtgacattca tgcgtgagcg 999721 gctgtctttt ctggcatgtc ctttatagaa gccgttgctt tcatcaatac agctgtagag 999781 aacctgcgct ttttgttcat tgcgctgttc aacagcttcc acaccgccgt tttccttgag 999841 ccattccaga acgaggctca gcatataaat cgcaaatgtc ggcggagtgt tgtagagtga 999901 atccgctttg acatgcgtgg aatatttcaa gatttttggg acgttcgcat tttcattttg 999961 cagccagctt tttttcatga tgactacagt cacgccggaa gggccgaggt tcttttgggc 1000021 gcctccgtag atcacatcaa atttggacac atcgattttt ctgcttaaaa tatcgctgga 1000081 catgtcggct acgagcggaa ttggagaatt cggaaactcc tgccactgag tgccgaaaat 1000141 tgtattgttg gatgtgatat gtaaatatgc gccgtctttt acatccgtaa ggtcaacctc 1000201 tggaatataa ctgtaattgt ctgtttcact tgtagcggtg atagacgtgt tcccgaacag 1000261 tttcgtttct gccagtgctt tttcagacca agcgccggtc atcacaaaat gtgcggtttt 1000321 ttcaggtgtt aaaaagttca tcggaagcat tgagaattga aggcttgccc cgccttgaag 1000381 aaacaagata tcgtaatctt ccggaatgcc catcagttcg attaagaggc ttttcgcttt 1000441 ttggtgcacc gcttcatact ctttgctgcg gtgggaaagc tccataacag acatgccgga 1000501 ttcgttaaaa tcaataaatt ctttctgtgc tttttgcaga acttccagtg gcagcgctgc 1000561 aggacctgcg ttaaaattcg ttgtacgttc cattatgatc tctccctgtt ttccacgtta 1000621 atgtataaaa taatacaatt atcctatcac aaaaattcag ttttttgata aaaaattaga 1000681 attatcaaaa gaaattgacg gatgtttgcg aaatgttcac aaaataaaat aacctcatct 1000741 tatgatgagg ccaggcgttt tgcgatagag gaagagatgt tctgcagatc ctccggttta 1000801 taatcatcag catgcgtttt ccaaaccgct ccgaatccat ctccttttcc gtagcgaggg 1000861 ataatatgca tatggtagtg gaacacagat tgtccagctt tttcgccgtt attgttcagc 1000921 gtatttaagc cgatcggttc aaattcatcc cggatagcgc gggcgatttt tggaacagca 1000981 tggaaatatt gttttgctaa ttcatctgta aattcatata cattctcaat atgtgttttc 1001041 ggaatgacaa gcgtatggcc ttttgtcact tggctgatat caagaaaggc aagtacatgt 1001101 tcatcttcat acaccttcgc tgatggaatg tcgccggcaa taattttaca aaagatacaa 1001161 ttctctgcac aatgcatgag ggttcctcct tatgaaattg tttagtatgt atacattcat 1001221 cgtaccacag aaatgcagaa aatagaaaac aggatgaacg gcgagcgttc accctgaatg 1001281 cagaggaaga gcttatatga agaaaatgtg ttatgccttt ggtaagcacc tcatttgtca 1001341 ataaaatgaa gacttgttta atgcctaacg attcctgcga taaacacctc atttgacaat 1001401 ttgcttcata catgaagaat tcatcaattc agtgaagaga aatggtttga gcattggaca 1001461 tgtttatttt ctatccaact gtttctaaga cgtctttgac aaacacctca tttttcagtt 1001521 gatatgcttt tcctctacaa cttttatgat gtccagaacc ctgtctcttt atgacagcaa 1001581 attcatcatt tgttaaaagg gaattgtttc aaatcaggcc ttgtttttgg tactatgaag 1001641 aaaaacacta taaggggaga aactatgtct ctgctatcgg taaaagactt gaccggcgga 1001701 tatacaagga atccggtttt aaaaaacgta tcattcaccc ttgaaccgaa tcaaattgtc 1001761 ggcttaatcg ggctgaatgg tgctggtaaa agtacaacaa tcagacacat catcgggctg 1001821 atggacccgc ataaaggttc aatcgaatta aacggtaaaa cgtttgctga ggatccggaa 1001881 ggctaccgtt cacaatttac ctatatacct gaaacacctg ttttatacga agaattgacg 1001941 ctgatggagc atcttgaact aacagccatg gcatatggac tgtcaaaaga aacgatggag 1002001 aaaaggctgc ctccgctact aaaggaattc cgaatggaaa agaggctgaa gtggttcccg 1002061 gcccattttt ctaaaggaat gaagcagaag gttatgatta tgtgcgcatt tttggcagag 1002121 cctgcgctct acattattga tgagcctttt ctagggcttg atccgcttgc cattaacgcg 1002181 ctgcttgaac ggatgaatga agcgaaaaaa ggcggggcga gcgtgctgat gtcaacacac 1002241 attttggcaa cggcagaacg ctattgcgat tcgtttatta ttttacataa cggcgaggtg 1002301 cgggcgcgcg gcacgctgtc agagctcaga gagcagtttg gaatgaagga cgcggcgctg 1002361 gacgatttgt atcttgagct tacaaaggaa gacgctggcc atgaataata tgcttgatat 1002421 ttggcagtcg cggctgcagg agcatatcaa agaaacaaga acatacatga aatatatgct 1002481 caacgatcac ctcgtcattg ttttgatttt ttttctagcg ggcgctgcaa gctggtacag 1002541 caaatggata cgggacattc ccgctcactt tccgtccttt tgggtgatgg ccgtgctgtt 1002601 ttcgctcgta ttgacaagct cttatgtgcg aacgcttttg aaggaggctg accttgtttt 1002661 cttattgcct cttgaagcaa aaatggagcc ttacttgaag caggcgtttg tctacagcta 1002721 tgtgtctcag ctgtttccgc tgattgcgct gagcatcgtt gcgatgccgc tttatttcgc 1002781 agtcactccg ggagcttcgc tcgtatcgta tgccgcggtc tttgtccaac tgttgctgct 1002841 gaaagcgtgg aatcaggtaa tggaatggcg aacgactttc caaaacgacc gcagcatgaa 1002901 acggatggac gtcatcattc gctttgcggc gaatacactc gttctttatt ttgttttcca 1002961 atctgtttat atgtatgcgc ttctcgtcta tgtcattatg gctgttcttt atctgtatat 1003021 gtcttccgca gcaaaacgga aaacatttaa atgggagagc catattgagt ccgaattgag 1003081 acgaaagcag cgtttctatc ggattgccaa cctgtttact gatgtgccgc atttgcgaaa 1003141 gcaagccaaa cgcagagctt atctcgactt tttgctgcgg cttgtgccgt ttgaacagcg 1003201 caaaacattt gcctatatgt tcacccgcgc ctttttgcgt tcgagcgatt atttgggcat 1003261 tcttgtcaga ttaacgatcg ttttcgcgct gatcattatg tatgtctcag ccagcccgct 1003321 gattgccgcg gttttgactg tgtttgccat tttcattacg ggcattcagc ttctgccgct 1003381 cttcggtcac tttgaccatc tggcgcttca agagctgtac cctgtgcaaa aagaaacaaa 1003441 gctgaaaagc tatttctctc tattaaaaac tgcacttagt attcaagcgc tgctgatgtc 1003501 tgttgcatct gcctatgcag ccggcttgac cggttttctg tacgcgctga tcggttctgc 1003561 cgttctgatt tttgttgttt tgcctgctta tatgacgacc aggctgaaaa agcacggaaa 1003621 gctgtgaact gaaaagaggt aatcaaatga cagataatca gctgctgatg caggaagctt 1003681 tggaatggaa aatgcatttt ttgcgaaagg attccatgtt tgaacgcttt tcgaagcgtg 1003741 tccagacgaa ggtgaatgaa cggattcctg aaaaaatcca tacggtcgtc accgagagtg 1003801 tgaaaaaaat ggtagaagcg acaatggccg gctctaatat catcacctat aaaaaggata 1003861 caagtgcact gtcgctcagt gaaaaaaacg aattggcgaa aaaaacgatt gtttcttatc 1003921 aaaaagtggc agctgctgag ggagtcggca ccggagcggg cggcattttt ttaagcattg 1003981 ctgattttcc gctgctgctt tcaattaaga tgaagtgttt atttaccttg tcttccattt 1004041 acggctttga tgtcaaggat gcacaagaaa ggatattttt gctgctcgtg tttcagcttg 1004101 cgttttcgag tgatgatggc cgtaagtcgc ttttttctgt catcgaaaat tgggagacgg 1004161 agaaaaagag catcgactgg agagtgttcc agcaggaata tcgcgattat atcgacgtcg 1004221 tgaagctttt tcagcttttg ccgggcgtag gagcggcagt cggcggaatt gccaattata 1004281 agctgcttgc tcagcttgga gaaacggcaa gacatgtttt tcatctgagg atattaaagg 1004341 aaacagccgg agaataaaca ctccggctgt ttttttatag ctgatgatag gtgatcgcag 1004401 cgccggcaag gaccttggcc gctgtcagca tggctttttc gttgatatca aatttcggat 1004461 ggtggtggga atagactcgc tctggctgtt cgggagcggc gcctgtaaag aaaaaagtgc 1004521 ccttcacgtt ttgtaagtaa taagcaaaat cctcgccgcc catttgtggt tcaccgtcaa 1004581 tgacctgctg aacgccctcg gtattctttg cggtgctcac caagtggttc gtttctgcag 1004641 gatggttcac aaccgctgga taaccctgtt cataggtgta ctcataggac gcgccgtgca 1004701 tgctgcatat tccttttaca accgcttcaa tttctttctc cagaatgtcc cggacatttt 1004761 catcaaaaga acgcgctgtg ccgatgagta ctgcttggtc tgcgatgaca ttaaacggat 1004821 tgtcggcgat gaaggagcct gtcgaaatga cggcggattg aatcggattg actttgcggc 1004881 tgacaatgtg ctgcaaagag gaaacgattt gcgaaccgat taggacggcg tctttagtat 1004941 catgcggatg agcgccgtgg ccgccctttc cgaagacttt aatcgtaaat cggtctgccg 1005001 ccgccattac ggcgccgggg cggcagagaa tagttccgag cggctcagtt gcccaaagat 1005061 gagtgccgaa tatcacatcc gtgttttcga gacatccgtc atcaatcatt ggctttgcgc 1005121 ctccaggata atattcttct gcatgctggt ggatcatcac aaatgttccc ttcagttcat 1005181 gtctgttttg gtgaaggacc ttggccactg cgagaagagc tgcggtgtgg ccgtcgtggc 1005241 cgcatgcatg catgacacca ggcactttgg aggcgtaagg gacatctttt tcatcttgaa 1005301 tggggagagc gtcaaagtcg gccctcaaag cgactgtagg gccgggttcg cttccttcta 1005361 tatttgctaa aacccctcta ccgccaacgt ttgtgcggat tgggactcct aacgattcat 1005421 aataggaagc aataaatgcg gcggtttttt cttcttgaaa tgagagctca ggatacatat 1005481 gaaaatggcg cctgatctca accatttctt caaaacagcc gtcgagctgt ttgtttatct 1005541 ctttctgcag tgtggatatg gacaaagccg cttccccctt ttctatgctt ttccatgatt 1005601 gtatagaaaa agtctgaata tttcaactca tgctgtttta aagcatcatc acagctgcga 1005661 gggttgtcac caaaaggcca atcgcgacgg gaatgaagtt ttttctggca agctcaaaag 1005721 gatcaacttt gcaaatggcc gcggcgggaa tcaaagccca tgggaccagt gttcctccgc 1005781 ccacccagat ggcagagatt tgtccgagcg cggtcagaat agcgggatcg gcatggagag 1005841 cggacgaaaa gagctttgcg atggagccgg cgagagaaat gccagaaaat cctgagccgt 1005901 caaggcctgt tatggctcca gcggcagtta atgcagtggc ggcaagctcc tttgacatag 1005961 gcatcatatg ggataaagca atgccaagat cgttgacaat gccgtgggaa cctttaggga 1006021 gtgaagtgcc cagtatgctt tcatagcctg agtcgccaag ataaaagaaa gcggcaatcg 1006081 ggatgacggg gccgaaaacc ttaaaaccga acttaaatcc gtcaataaaa tagccggtga 1006141 ttttttcaag ccctttatgc ttatacacga aaaaatgaac ggtaaagagg atacaaattg 1006201 cagacccgcc aattaacgcg gttgcatcat ttccttgtag gttaaacaag agcatgcagg 1006261 cgatatctgc aagaaaggca agcggaatca aaaaagccag tatggaccgc aggcgttttg 1006321 gcaagtacag cgagttgtct tgttcgccgg aaagaacggg ggaaaaagaa gtgggatgct 1006381 cctgtttttt gcgttcgcgc tgaatcatga taaaggcagc agttgttgtt gtcacaccca 1006441 taatcagcac aagcggaata ctggccgaga cgacatcacc gactggaatg cctgctgcat 1006501 ccgcagtcag ctttggcgcc gcctgaatga caaagtctcc tgacagggca aaaccgtgtc 1006561 cgaataagtt catggccatg gccgcggcaa gaggcgtcaa accggcacgt gcggctgcgg 1006621 ggagcaggac ggcgccgatc aaagcgacac ccggagaagg ccagaagaat agagaaatgg 1006681 cgaacatcag gcctccaatc agccaatagg cagtcacagg ccctctcaca aggcttgcaa 1006741 agggagaaat catcgcttca tttatccctg tttttgttaa caaatcactc attgaaacga 1006801 taaagcaaat gatgaaaatc gtgggcagca gttcgccggc cgcatagata aagctgtgga 1006861 ataaactgct gacagaagct gaaagtgaat ggctggccca tagcgatatg ataaaaatgc 1006921 cgaatagaga aataaatgtc gtgtcttttc tcagcagcat aaataggata attgcaccga 1006981 taaaaaacac atacagaaca tggacaggca aaatcccgac ttccatcatc gatcactcct 1007041 tccgcttaca gattattcat aggcgggcgg aaggtgccgg gacagagggg agggttatga 1007101 tggaagatga acattgatct gtttcagctg ctcaatcaga tgatgcctta atcctctatt 1007161 cgctttttgc agatgttttg ggaagcattc aggagaaaaa atgacgcacc cttcagcaag 1007221 ccagtttttt ctataggcga tgatgctttc cgatggctct atatgagtta tcctcgtgct 1007281 gcatctcgta ctcatcaaat ccgaactgaa aaccgcagca cgggcagatt tcatgagaat 1007341 gattgccttc atgatcatat ggcggttcag ccaatcctta aacccgcaga ctgggcaagt 1007401 atgcttcatt ttgctttcct cccaataaaa taagctgccg gacatgccgg cagctattcg 1007461 acagcgaaat atgtggtgac ataggaaggc cgggagaaga tcgacgttgt gtcaattccg 1007521 gcagatgtat cgcgtttttt gtgggcttct ttgtaagaac cggactgctg ccagtcttga 1007581 aaggcgcttt ccgtttccca caaggtcaga atgacatagg tgtcactgtc aagcggacgg 1007641 agcactcgaa ttgcttcaaa gccaggctcg ttttcgactt ttcccgctct gtttttaaat 1007701 ctgttttcaa acagcggacg cccttcctga gtaacggcaa tattgttcaa tactgcaaaa 1007761 ccgggatgtt tgatctctcc gacttggtca atgacttcat aagcgtgtgg tgcctggaaa 1007821 acggtatctc cgtttgtttc atgaattaaa atggcgtttt cctgcccctg catcaaaagg 1007881 atattttctg agggatgctt ctgtacgatc gtttttaaaa aatcggctgt cccatatgta 1007941 atataaacct tcatatcagc cacctcctgc ttgctagtat atcaaaacaa tggtataagt 1008001 ttctattggc gagtgcttcg aacataattc caaacaattt ttcccatact acctttagaa 1008061 aggcgaggtg agttcatgtt taagataaag aaaaagaaac tttttatacc tatcattatt 1008121 ttagtgttaa ctgcttttct cgctttaata ggatatattt caattatttt tctcggccat 1008181 tatgtcatag atgaaaaaaa gcttattctt catgcttctt caaaaattgt tgatcaaaac 1008241 ggagatgagg ttgcaagcct gtatacagaa aatcgcgagc cggtctcgat caatgagatt 1008301 cctaagcagg tcagagaagc gtttatcgct gttgaggata aaaggttcta tgagcatcac 1008361 ggcattgatg caaaatccgt cggaagggca gtgtaccgcg atatattagc aggcggaaag 1008421 gtggaaggcg gaagcacgat cacccagcag cttgccaaaa atatttttct gacacatgac 1008481 aaaacatttc taagaaaaac aaaagaagtg atcattgcga ttaatcttga acgggattac 1008541 agcaaggaca agctgcttga aatgtattta aaccagcttt acttcggaca cggggtttac 1008601 ggcatacaag cggcgtccca ctattatttt aataaagaag taaaagattt gactgtatct 1008661 gaaggcgctg ttttggccgc tattccgaag gcgccttcta cgtactctcc aattttgcac 1008721 cctgataaaa ataaggagcg gcgtgataca attctaggta tgatgaatga ccaaggctat 1008781 atcagtgcga aagaggctgt caccgcacag ggccggacgc ttggactgca tgtgaagaaa 1008841 cagtcggaaa caccttggtt tgacagctac attgaccttg tgatcaaaga ggcggaagac 1008901 aagtattcca tttccggaga gcagcttctt caaggcggat acacgatcaa ggtgccgctc 1008961 gattcgaagc tgcagaagac ggcttaccag gtgatgaaag agggaagcta ttatcccgga 1009021 acagatcaga atgccgaggg aagcgcggtc tttattaata acaagacagg cggtgtagaa 1009081 gcggccatcg gcggaaggga ttacacatcc aaaggatata accgtgtcac agctgtccgc 1009141 cagccgggtt ccacatttaa gccgcttgct gtatacggac cggcgatgca ggaaaagaaa 1009201 tttaagccat attctctatt gaaggatgag ttgcagtcct acggagatta tacgccgaaa 1009261 aactacgaca gccggtatga gggcgaagtc actatgtctg acgccattac gtacagcaaa 1009321 aacgcgccgg ctgtctggac gctgaatgag atcggcgtcg aaacagggaa atcttatttg 1009381 aaagcaaacg gcattgatat ccctgatgaa ggccttgctc ttgctctagg cggcttggaa 1009441 aaaggcgttt caccgctcca gcttgccggc gcgtttcata catttgccgc gaatggaacg 1009501 tatactgaac ccttctttat ctcgagcata atagatgaag acggagaaac aatagccgat 1009561 cataaagaag aaggaaagcg ggtattcagc aagcagacgt cttggaatat gacgagaatg 1009621 ctgcagcagg tagtcaaaaa gggaacggcc acgtccggca cctatcacgg cgacctggcg 1009681 ggaaaaacag gttcaacatc ttatacaggc gtctccggcg cgacaaagga cgcctggttt 1009741 gcaggctata cgccgaaaat aaccggggca gtctggatgg gctatgacaa aacggatcaa 1009801 aaccattatt tgaaagccgg gagctcatac ccgacgcggc tgtttaagga tattttgaca 1009861 caggcaggag aaaccggtca tgtgttcaca aagcctaaaa acgttaaaga actggaaagc 1009921 ccgattgagc tgaagccggt caaaacactc acagccgatt acacatttaa agcagcgggg 1009981 ctctttacta ttgaattaaa gtgggacgct caagaggatg atcgggccgt atacagaatt 1010041 tatgtaaaca aggacggcga ggagacgctt cttgattcgg ttgaagggaa gggaagctat 1010101 gaaattcctt atgccaactt attttcgggc gcgtcttata aaattgtgcc ttataataca 1010161 cagacaaaaa gagaagggga aggaaccgat tacgttcagc caaaattgtt ttcctcttaa 1010221 tggaattcgg cgattttttg aactttgagc tacatttcta taccatttgc ctaaaacaag 1010281 gtatagtgta ataagtcaag aaatacgaac gtatggttgc cgtatgaaag gtggaaatca 1010341 gatgagtaaa cgagaaacgt ttaacgagac gtttttaaaa gctgcgcggg gagaaaaagc 1010401 ggatcacacg cctgtgtggt atatgaggca agcagggcgc tcacagccgg aataccgcaa 1010461 gctgaaggaa aagtacggat tgtttgagat cacacatcag cccgaacttt gtgcgtatgt 1010521 cacaagactg ccggttgagc aatacggagt cgatgctgca atcctttata aagatatcat 1010581 gacgccgctg ccgtcaatcg gtgtggatgt tgaaatcaaa aacgggatcg gtcctgtgat 1010641 tgatcagcca atccggtctc tggcggacat tgaaaaactc ggccagattg atccggaaca 1010701 ggacgtgccg tacgtgcttg agacgattaa actgcttgtc aatgagcagc tgaacgtccc 1010761 gctcatcggt ttctcaggtg cgccttttac gcttgcaagc tatatgatcg aaggcggccc 1010821 gtcgaaaaac tacaataaaa caaaagcctt catgtacagc atgccagatg catggaatct 1010881 gctgatgtcc aagcttgccg acatgatcat cgtgtacgtg aaagcgcaga ttgaggcagg 1010941 cgcaaaagcg attcaaatct ttgattcgtg ggtcggcgca ttgaatcagg cagattacag 1011001 aacatacatc aaacccgtga tgaaccggat cttttcagag ctcgcaaagg agaatgtgcc 1011061 gctgatcatg tttggcgttg gcgcaagcca tcttgcaggt gattggcatg accttcctct 1011121 cgatgttgtc gggcttgact ggagactcgg cattgatgaa gccagatcaa aaggaattac 1011181 taaaacagtg cagggcaacc tggacccgtc cattttgctt gcgccatggg aagtcattga 1011241 gcagaaaacg aaggaaatac ttgatcaggg tatggagtca gacggcttca ttttcaatct 1011301 tggccatggg gtatttcctg atgtcagtcc cgaggttttg aaaaaactga cagcatttgt 1011361 ccatgaatat tcacaaaaca aaaaaatggg tcaatattcc taagcatatc ttttggtatc 1011421 ttaatgatat cctgtcaaaa tgtttgtatc agatcattaa agagggtgta aacagtgagt 1011481 agaaagaaaa tggggcttct cgtgatggcg tacggcacgc cttataagga agaagatatt 1011541 gaacgttatt atacacatat cagaagaggc agaaagcctg aacctgaaat gcttcaagat 1011601 ttgaaagaca gatacgaagc gattggcggc atttcaccgc ttgcccaaat cacagaacag 1011661 caggcgcata atctggaaca gcacttgaat gaaattcagg atgagattac gtttaaagcg 1011721 tatatcggac tgaagcatat cgagccgttt attgaagacg ccgtagcaga gatgcataag 1011781 gatggcatta cagaagcagt cagcatcgtg ctggcgccgc atttctccac gttcagcgtt 1011841 cagtcctaca acaaacgcgc caaagaagag gctgaaaaac tcggcggctt aacgattacg 1011901 tcagttgaaa gctggtacga tgaaccgaag ttcgtgacat attgggttga ccgagtgaag 1011961 gaaacatatg cgtcaatgcc tgaggatgaa agagaaaacg caatgctcat cgtatccgca 1012021 cacagcctgc cggaaaaaat caaagaattt ggagacccgt acccggacca gcttcatgaa 1012081 tcggcgaaat taattgctga aggcgcaggc gtttccgaat atgctgtcgg ctggcaaagt 1012141 gaagggaaca cgcctgatcc ttggctcgga cccgatgttc aggatttaac acgtgattta 1012201 ttcgaacaaa aaggctatca agcatttgta tatgttcctg ttgggtttgt cgcggatcac 1012261 ttagaagtgc tttatgataa tgattatgaa tgcaaagtgg ttactgacga tatcggcgca 1012321 agctattacc ggccggaaat gccaaatgcc aagcctgaat ttattgatgc tttggcaaca 1012381 gtcgtattaa aaaaattagg acgttaaaga aggcgatgaa catgagtgac ggcaaaaaac 1012441 atgtagtcat catcggcggc ggcattaccg gtttagccgc cgccttctat atggaaaaag 1012501 aaatcaaaga aaagaatctg ccgcttgagc tgacacttgt tgaggcaagt ccgagagtcg 1012561 gcgggaaaat ccagactgtc aagaaagacg gctatatcat cgaaagaggg ccagactcat 1012621 ttctggaacg aaagaaaagc gccccgcagc ttgttaaaga cttaggtctt gagcatttgc 1012681 ttgtcaacaa tgcgaccggg caatcctatg tgcttgtaaa ccgcaccctg catccaatgc 1012741 cgaagggcgc tgtaatgggg ataccgacaa aaattgcgcc gtttgtttct acgggtctgt 1012801 tttccttgtc cgggaaggcg agagctgcta tggatttcat cctgcctgca agcaaaacaa 1012861 aggatgatca gtcattggga gaattcttcc gcagacgtgt cggagatgaa gtggtcgaga 1012921 acttaatcga gccgctacta tcagggatct acgcaggcga cattgacaag ctcagcctga 1012981 tgtcgacatt tccgcaattt tatcagacgg aacaaaagca tagaagcctg attctcggca 1013041 tgaaaaaaac aaggcctcaa ggctcaggcc agcagctgac ggcaaaaaaa caagggcagt 1013101 tccaaactct gtcaaccggt ttgcagaccc ttgtagaaga gatcgaaaag cagttaaagc 1013161 tgacgaaggt gtataaaggc acaaaagtga ccaaacttag ccatagcggc tcttgctatt 1013221 cgctcgaact ggataacggc gtcacacttg atgctgattc agtaattgtg actgctccgc 1013281 ataaagcggc tgcgggaatg ctttctgagc ttcctgccat ttctcatttg aaaaatatgc 1013341 actccacatc cgtggcaaac gtcgctttag gtttccctga aggctccgtc caaatggagc 1013401 atgagggcac gggttttgtc atttcaagaa acagtgactt tgcgatcaca gcctgtacgt 1013461 ggacgaataa aaaatggccg cacgcagcgc cggaaggcaa aacgctgctt cgggcatatg 1013521 tcggaaaagc cggagacgaa tccattgtcg atctatcaga taatgacatt atcaacattg 1013581 tgttagaaga cttaaagaaa gtcatgaaca taaacggcga gccggaaatg acatgtgtaa 1013641 cccgatggca tgaaagcatg ccgcagtacc atgtcggcca taagcagcgt atcaaggagc 1013701 tgcgtgaagc acttgcatct gcgtatccgg gtgtttatat gacaggcgct tctttcgaag 1013761 gtgtcggcat tcccgactgc attgatcaag gaaaagctgc cgtgtctgac gcgcttacct 1013821 atttattcag ctaaaacctc cgctttatcg cggaggtttt tttgatgtgc aatggcaata 1013881 ttgtgtaaaa aatgattgaa ttgaacagca ggttatgata catttgcata tgtacttaat 1013941 gactaaaatg ttcaaacggt cagtttcgag gtgaatacaa tgtcaataga tcgaaaaaag 1014001 ctcattttgg aggcggctac aaagtctttc acgcagttcg ggtataaagc gacgacaatg 1014061 gatcttgtcg caaaacttgc gaacgtgggg aagggaacca tttatacttt tttcaaaaac 1014121 aaagaagagc tgtttgacga gattttcact actttattaa aggaaatgaa gcaaaaagcg 1014181 gatgaagcga tggagccgag ccttccgttc catgaaaatg tgcacagagc gctgtttgcc 1014241 attctggagt tcaggaaaac acatcagctg acgattaaaa ttttccaaga gaatgccgag 1014301 attggtacaa tggcagttca ggaagtgatc cagaaaatgg agcgatccat cctgtcttat 1014361 atcaaaagca agattgaaga cgggatcaaa agcggcgcaa tcaagccgtg cgaccctgag 1014421 ctgacagcct ttgtgatgct gaagctttat atcgcgctca tttttgactg ggaaaaacaa 1014481 caccccccgc ttgataaaga gacaattgcg ggactgcttg aattgtatgt tgtcaaagga 1014541 ttgtcagcga actagataat cctttctctt tgcaagaaaa tgaccatttt ttatgatgag 1014601 tcagttttag aatggaggca tcaggatgaa cacaatacga agtcagtgga aagacatcgt 1014661 aacaagtaaa aaattattga ttcccatcat cgccattttg tttgtcccgc ttatttacag 1014721 cggcgtattc ttaaaggctt attgggaccc gtacggcaca gttgaccagc tgcctgtcgt 1014781 tgtcgtcaac caagacaagg gagcaacgta tgaaggagaa aaacttcaaa tcggtgatga 1014841 tctggtcaaa gaattaaagg ataataacaa ctttgattgg catttttcca atgatctcga 1014901 ccaatcgtta aaggacttat tgaatcaaaa atattattta gttgtcgaga ttcctgagga 1014961 tttttctaag aatgccagca ctgtattaga caaaaatccg aaaaaattgg atctgaaata 1015021 ccatacaaat gcaggttcta actatgtagg ggcaacgatc ggcgaaaaag cgattgataa 1015081 actgaaagcc tctgtttcaa aagaagtgac cgagcaatat acgaaagtta tttttgataa 1015141 ctttaaagat atcgcaaaag gtttgagcga cgcgagcagc ggcgcgaaaa aaattgatga 1015201 cggcacaaag gatgcgaaaa acggaagcgc ccagctgaaa gaaaatctgg cgaagctgaa 1015261 ggaaagcacc gctaccatca gtgacaaaac agcgcagctt gcagatggag cggctcaggt 1015321 gacgagcggc atccaatcac ttgacagctc gctcggtaaa ttccaggaca gcagcaacca 1015381 gatttatgat aaatctagtc agcttgcagc aggatcaggc gagctgacaa gcaagatgaa 1015441 tgaacttctt gccggacttc aaaatgtgca gaagggtacg cctaatctta ctaacgggtt 1015501 ggatcagctc aacagtaaag tccaagaagg ttctgagaaa gcggcaaaag cggaaaagat 1015561 cattaatgcg ctcgatttaa cgaagcttga aactgctgta aacaatctgg aaaagtcaga 1015621 aactgcgatg aaggaattca aaaaacagct gactgacttt gaaaacagtt tgaaaaaccg 1015681 tgatcaggca tttaaaaatg tcatcaattc gagtgacttc ttaacagcgg agcaaaaaag 1015741 ccagctgatt aattctgttg agaaaaagct tccgcaagtt gatgcgcctg attttgatca 1015801 aatattaagc cagctaccta cagctgatca gctgcctgac atcgcaacga taaaaagctc 1015861 tcttgaagac gtgaaagcgc aggtggcgca ggtgaaagcc atgccggaag ctacatctaa 1015921 gctttataac ggcgcaaaaa caatccaaga tgcgattgac agattaactg agggagctga 1015981 taagatatac aacggttctc agaagctgac agatggccaa actaaactga cagcgggcat 1016041 cggtgaatat aataagcagt tcgcaaaagc aaaagcgggc tcagagcaat tggtgacagg 1016101 aagcagccaa gtatccggcg gattgtttaa gctgttagac gggtctaaac aggtccaaag 1016161 cggatcatca aaacttgcag acggatctgc atcacttgat acaggtttag gcaagctatt 1016221 ggacggcaca ggagagctgt ctagtaagct gaaggatgcg gctgaccaaa caggagatat 1016281 cgatgctgat gatcaaacat acggcatgtt tgcggatccg gttaaaacca aagatgatgc 1016341 cattcattcc gttcctaact atggaacagg gctgacacct tatatcctgt caatgggctt 1016401 gtatgtcggc ggcatcatgc tgacggttgt cttcccgctg aaggaagcgt caggacgtcc 1016461 gagaaacggt tttgagtggt tcttcagcaa attcaatgtc atgatgcttg taggaatcat 1016521 tcaatcattg attgtggcga cggttcttct attgggaatt ggtcttgagg tagagagcac 1016581 gtggagattt tacgtgttta cgatcattac gagtctcgct ttcctggcga taattcaatt 1016641 tttggctaca acgatgggca acccggggcg atttatcgca gtcattattt tagtgctgca 1016701 gctgggagcg agcggaggaa ccttcccgct ggaattgctt ccgaatttct atcaggtcat 1016761 ccacggcgca ttgccgatga cctacagcat taacggattc agagcagtca tttcaaacgg 1016821 tgactttggc tacatgtggc agatggccgg cgtcttaatc ggcattgccc tcgtcatgat 1016881 tgcactaagc attacttact ttacaatgtt aagccggaag gaagaaacat cagaagaaca 1016941 gccggcttca taaagaaaaa gaacttgttt ccttggaaac aagttctttt tttgttacat 1017001 cccccattta ataagcaatc ctgtataggt taatccgccg ccaaacccga aaagcaaaac 1017061 gatttgatct tttttcagct tcccggcttt cactgcgaga tcgagcgcca aaacaattga 1017121 aaccgaagac gtgtttccgt agtgctcaac actagtgagc gttttttcaa tcgggaacgg 1017181 tgttttttca caaattgact cgatcatgcg caagttggcg ctgtgaggaa caaaccaatc 1017241 gagatcatcg gagctgagtc ctgctttatg taaaagccgt tcaaattcgc cagggacggt 1017301 tcttgcggcc catttatata cctcgcgtcc gttttgcacc atttttccgg aaccgacaag 1017361 ctgcacaccg tttatttcat ttcgcagtcc ggcacgatac aaaatatcgc cgccgttccc 1017421 gcttgttcct tgtacagacg caagaaatcc cggcgtctct tcatctcgtt ctactaacag 1017481 cgcacccgcg gcatcgccga acagtacgca tgtcgttcga tcggtataat cggttacctt 1017541 tgataacgtc tctccggcga tgacgagaat tttttgatga aggccagatg tgatcaatcc 1017601 atttgccaaa tggaggccgt atgtcagccc ggcgcatgtc gcattaatat ccagcgcgcc 1017661 ggtgctttcc cagccgaaat attcctgtac gcggcatgcc gtactcggaa aggcgtaatc 1017721 ggatgtggtt gtggcaacga ggatcatatc gacatcatca agcgttcctt tataacggct 1017781 cttgagattc ttcaccgctt ctatgcataa atcagaggta aattgatgtt catccgcaat 1017841 ccggcgttct ctcattcctg tgcgctgaac gatccattca tcagaggtat caacgatctt 1017901 ttctaaatct gcattggtta aacgtctgct cggcgcatag gtgccgatag ctgtaatttt 1017961 tgcttttgac atatgaatca ctccttatgg tcagattata acactagata ttagtatctg 1018021 gtactaaaaa gaaggttttt ttacaaaaaa agagaagtgt agataggaat ctatgaaaaa 1018081 gaaaaaggag gctgaaaaat ggtcagtcaa gaagcagtag tctttttggc attatccggg 1018141 gctattgcgt ttctgttgcc aatcgggctg attgtatggt ttaagcgaaa gtatggtgcc 1018201 tcgcttaaag tgttttttat tggcgctctc acgttttttg tcttcgctca gctgctggaa 1018261 ggcggcgttc atgtttatgt actgcaagtg aatgaaatga cgaaagaagc gatgcagcat 1018321 ccattatggt atggcattta cggctgcttg atggccggca tttttgagga gtgcggaagg 1018381 tatttgatga tgcgattttt tatgaagcgc catcatactt gggcagatgg tctggctttc 1018441 ggggcaggcc atggcgggct tgaagccatc ctgattacag gcttgtcctc tatctcactt 1018501 attgtatacg catttgcaat caatagcggg acgtttgaac agcttttggt caatggcgac 1018561 gtcaaacagg cgcttttgcc gatacaggag cagctgctgc atactccttc gtatgaatgg 1018621 atgctgggcg gaatagaaag aatcagtgcc attgccgtcc agattggtct gtctctgctt 1018681 gttttgtacg cggttaaaaa ccgccggccg ctgtttttgc tgtattctat tcttttacat 1018741 gcactgttta atgtcccggc ggttttatat caaagaggaa tcatagagca tgctgcagct 1018801 gttgaaatca ttgttgctct tatagcggct ttatcagttt attggattgt aaaagcaaaa 1018861 agggtgtttc aataaaaggt ccaagcagca gcaatgcccg cttggaaaaa tgtgaatgga 1018921 aatattcatt aagcatgggt catcagaata tttctgattc agtctttagc aatgacagca 1018981 agaatgtctg tgttttttac aagagaaaca atggtgtttc tttttcttct tctcgcaagg 1019041 gtcatggcat tctttctttt tcttgcaatg gtcgtggaaa tctttatcga accactcgtc 1019101 aaagaaccaa aaatcatcga accaatcgtg acaacgacat ttctgttcat gtgaatgacg 1019161 acagcacata gaaatccctc ctcttcccat gctctctaca gcatatgaga gattgatagg 1019221 aaaagattgg acgggtccct cgggaaaaga gtatatttta agtagaaaat aaaaggagga 1019281 atgccctatg acgtccgtac gtaaaacgat ggagctcatt aaagaacttg tatcgatccc 1019341 aagcccgaca ggaaatacat atgaggtgat caattatatt gaaagccttt taaaagaatg 1019401 gaaggtagaa acggttcgga accacaaggg cggcttaatt gcaacgcttc caggacgcga 1019461 cacatcccgg catcgcatgc tgacagcgca cgttgacacc ctcggcgcta tggtgaagga 1019521 aattaaagcg gacggccggc tgaaaatcga cttaatcggc gggttccgct acaactcgat 1019581 tgagggggag tattgccaaa ttgaaaccgc ctcgggaaaa atgtacacag gcacaatctt 1019641 aatgcatcaa acgtctgtgc acgtatacaa agacgcggga aaggctgagc ggaatcaaga 1019701 gaatatggag atccgcctag atgaacctgt tcactgccgg aaagatacgg aggagcttgg 1019761 cattggcgtc ggagactttg tgtcgtttga tccacgtgtc gagatcacat caagcggatt 1019821 tattaaatcg cgccatttgg atgacaaagc aagcgtcgcc ttattgctcc gcttaattca 1019881 tgaaattcaa acagaagaca ttgagctgcc gtatacaacc cattttctta tttccaataa 1019941 tgaagaaatc ggttacggcg ggaattcgaa tattcctcct gaaacagttg aatatttggc 1020001 ggttgatatg ggcgctatcg gtgacgggca ggcgacggat gaatattcag tatcaatctg 1020061 tgtgaaggat gcgagcgggc cgtatcatta tcagctcaga aagcatttag ttcaattagc 1020121 cgagaagcat catattgact ataagcttga tatatatccg tactacgggt ctgatgcgtc 1020181 agcagcgatc aaatccgggc atgatattgt gcatggcctc atagggccgg gaattgacgc 1020241 ttcccatgca tttgaacgca cccataaatc atctcttcgc cataccgcta agcttctgta 1020301 ttactatgta cagtcaccaa tggtataagg gggaggacca atgaagattt ataagctgaa 1020361 aagcacattc ggttgggaag gtgatgacgg gttgggagaa cagctgattc agcagatcct 1020421 tgccggagaa aaaagcgcca cgtgcgcgcc gaaatcattg tattcaaaag atgaattgag 1020481 ggacgtttat caaacagcgg gtcagcttgt taccgtttat gataaacatg acaatccaag 1020541 atgcaatata aaagtaacag atgtctttga aaccaccttt ggtgcgcctg atatgaggtt 1020601 agtcaaagga gagggcaatg gagaccgaat tgaggagttt caagaggatc atcggatggc 1020661 atgggcggaa ctgatcaaaa gcggtgaact ggagctgaat gaggatactg ttttgattac 1020721 agagttgttt gtgcttgtta aagattaaaa aagcctgcgg ggcaagaacc ccgcaggctt 1020781 ttcattaacc agaaatggtt gcgttttgtt ctgttttcga ttgggacata acagtttctg 1020841 ctttcgcagg attaaacatg ccttcccatt tagacatcac aacggcagca agcgcgttac 1020901 cagtcaggtt gacaactgta cgtgccatat ccatgatgcg gtctacgccg gcaataaagg 1020961 caagtccttc agccggaacg ccgatggtgc caagcgttgc aagcaagaca acaaaagaag 1021021 taccaggtac ggcagccatc cctttggatg tcaccattaa gacgagcaca agcgtaattt 1021081 ggtgccaaat cgtcaaatca atgccatata cctgtgctaa aaagagtgcg gcaatagatt 1021141 gatagagaac ggaaccgtct aagttaaacg tgtaaccgat cggaatgaca aatgaaacaa 1021201 tgccttttgg acatccgatt ttctccattt tttccatgat acgcggaaga accgtttcag 1021261 agctggacgt actgaacgcc agtaagattt cgtccttcat gtaagcaagg aacttgaaga 1021321 tgctgatgcc ggcaattttt gcgacaatcc cgaaaataac aattaagaag aaagcaagcg 1021381 cgacataaac caatccgacg agctttccga gagagataag agaaccgagt ccgaatttag 1021441 acacagtcac tccgataaga gcgaaaacgc cgaatggcgc cactttcatc acaaggttta 1021501 caacgtggaa catggcatgg gatacacctt caaaaaaggc taatacaggc ttgcctcttt 1021561 caccgatcgc ggaaataccc aatgcaaata gtactgtaaa gcagatgatg gctagaagat 1021621 ccccttcgac caatgactgg aagaagtttg tcggcacaat atggaggaac gtttccgcca 1021681 ctgatttatt actttgttct ttttcagttt caacatattg actgatgtcc gatttttgag 1021741 cttcgtgtat attaactcct gtacccggat ggaagatgtt tgcaagggct agtccgagaa 1021801 taatggcaaa agtcgtgatg atctcgaagt acagaatcgt tctgaagcct aatttaccga 1021861 cttgctttcc atttcctgca ccggctacac cgatgattaa gctggagaca acaataggaa 1021921 tcactatcat tttgattaag cgtaaaaaga gatccccgat tggctgcagg taagtaggca 1021981 atgctgggtt gccataccaa atgacgccaa caatgacacc tagaataagt ccaacgaata 1022041 tttgtgtggc taatccaaac ttaattcttt tcatagatta cctcccaaaa aacaaagtat 1022101 caacatatat catgaataga catatattta atctcactat tagatcaaat tataatagat 1022161 aagaaatcaa ttcgtctata gtaaattata tttcgaaaat aaagaatatt caatgacatt 1022221 atgataatca ccagaattat ctaaaaacag gtgagctttg acctaacctg actattattt 1022281 caaaattaag agatatgtga aaaaataaga aaatcccacg cgtaaggcgc gggattttcg 1022341 ctcattacaa atcgtttact tttatacagt cattgcagat attaccataa cactcatgct 1022401 gctcttctat cttttttccg cattccgcac actttttcga aggcaggttt ctaaaaaatt 1022461 ctgtgatttt ccccagcata accaatccct ctttcccctt tgtagtgatt tcattgtaat 1022521 ataacagatt acaaaaatca ataactgttt tgatacaatg tttaaaacat gcttttttca 1022581 agaaaaatgg gtatattgaa ggaggaccaa tttttttgaa aagataggag gacattatga 1022641 aagttacagt tatcggatgc tatggcggtt ttccggccgc aaatgaagcg acgtcaggct 1022701 atttgtttca gtcaggtgat tactctctgc ttgttgattg cggcagtgcc gtattgtcta 1022761 agctgttcgg atatgtgccg gcggaaaagc tggatgcggt cgttctgtct cattatcacc 1022821 atgaccatat cgctgatatc ggaccgctgc aatttgccaa gcaagtcggt tcgtttctcg 1022881 gcaaaggaga gcatacgctt ccgatttacg gacatgatgc tgatatagaa cagtttcaaa 1022941 agcttacata taaaacacat acaaaaggga tcgcctatca gccggatcag ccgctgactg 1023001 ccggtccgtt tacgatcacc tttttaaaaa cgattcaccc ggtgacgtgc tatgccatgc 1023061 ggattactga cggcagccac actgtcgttt atactgctga ttccagctat caggattcat 1023121 ttataccgtt ttcgaaagat gctgatttat tgatctcaga atgcaatttt tatgccgatc 1023181 aagacggaac aagtgcaggc catatgaaca gcctggaagc tgggcgcatt gcaaaagaag 1023241 ccggagcggg agaactgctg ctgacacatt tgccgcattt tggcgtgcat gacaaccttc 1023301 gcaaagaagc gaaaaccgtt tttaacggag aagtgaatat tgcgaaatca ggttttgtgt 1023361 gggaaggata aaggaggagc accatgttat ttatagacaa tcaaaatatc aatgatccgc 1023421 ggatcaatct tgctatcgag gagtactgtg taaagcattt agaccctgaa cagcaatatt 1023481 tgctctttta tgtgaatcaa ccgtctatta tcattgggaa aaaccaaaat acaatagaag 1023541 aaatcaatac aaaatatgtt gaggaaaacg ggattatcgt cgtccgccgt ttatcaggcg 1023601 ggggcgctgt gtaccatgat ctggggaact tgaacttcag ctttattacc aaggatgacg 1023661 gggacagctt tcataacttt aaaaaattca ctgagccagt gattcaggcg ttacatcagc 1023721 ttggggttga agccgaatta agcggccgga acgacattgt agtagatggc cggaaaatat 1023781 ccggaaacgc tcagtttgca acgaaaggcc gtattttcag ccacggcacc ctcatgtttg 1023841 attcagccat tgatcatgtt gtatcagcat taaaggtgaa aaaggataaa attgaatcaa 1023901 aaggcatcaa atcgatcaga agccgagtgg caaacatcag tgagtttctc gatgataaaa 1023961 tgaccaccga agaattccgc agccatttgc ttcgccatat ttttaacaca aacgacgttg 1024021 gaaacgtgcc ggagtataag ctgacggaaa aagattggga gaccattcat caaatttcga 1024081 aagagcgcta tcagaattgg gattggaact acggccgctc accaaaattt aaccttaatc 1024141 attcgaagcg ttatccggtt ggatcgatcg atttgcacct ggaagtcaag aaaggcaaaa 1024201 tcgaggactg caaaatcttc ggagatttct tcggtgtcgg tgatgtatct gaaattgaaa 1024261 acctgctggt cggaaaacaa tacgaacgca gcgtcatcgc tgatgtgctc gaaggtgtga 1024321 atctcaagca ttactttggg aacattacga aagaggattt ccttgatctg atttactaag 1024381 gcaaaacaca tcgtttgaaa gagcggttgt gtttttgaaa taatggaggc aggagggatt 1024441 cacatgaaag tgtttttaat cggagcgaac ggacaaatcg ggcaaagact cgtctcttta 1024501 ttccaagata atcctgatca ttccatcaga gcgatggtca gaaaagaaga acagaaagcg 1024561 tctcttgaag ctgccggtgc agaagctgtg cttgcgaatc tggagggcag cccggaagaa 1024621 atcgccgctg cggcaaaagg ttgtgacgcg atcattttca cagccggttc cggcggcagc 1024681 acaggctatg ataaaacgct gctggtggat cttgatggag cggcaaaagc cattgaagct 1024741 gcggccattg ccggaatcaa acggtttatt atggtcagcg ccctgcaagc ccataaccgt 1024801 gaaaattgga atgaggcact caagccttat tatgtggcca agcattatgc tgataaaatt 1024861 ctggaagcga gcggtttaac ctatacgatt atccgtccgg gaggccttcg caatgagcct 1024921 ggaacgggaa ctgtttcagc agcgaaggat ctggagcggg gatttatttc ccgtgatgac 1024981 gttgcaaaaa cggtcattgc ctctttagat gagaagaata cggaaaatcg ggcctttgat 1025041 ctgacagaag gagatacgcc gattgccgaa gcattgaaga aactatgaca gtactgacac 1025101 tcagggcttt ttgctcttga gtgttttttt ctgtttctct ataatggaga agaaagcttg 1025161 gcttcaataa tgaatgacta ttcattcact taaggggtgg gagaatgaat cttgtttcaa 1025221 aattggaaga aacagcatct gagaagcccg acagcatcgc atgcaggttt aaagatcaca 1025281 tgatgacgta tcaagagctg aatgaatata ttcagcgatt tgcggacggc cttcaggaag 1025341 ccggtatgga gaaaggggac catttagctt tgctgcttgg caattcgcct gattttatca 1025401 tcgcgttttt tggcgcttta aaagctggga tcgtagttgt tcccatcaat ccgttgtaca 1025461 cgccgacaga aattggttat atgctgacaa atggcgatgt aaaggcaatc gtgggcgtta 1025521 gccagctttt gccgctttat gagagcatgc atgaatcgct gccaaaggtt gagctcgtca 1025581 ttttatgcca gacgggggag gccgagccgg aagctgcgga cccagaggtc aggatgaaaa 1025641 tgacaacgtt tgcaaaaata ttgcggccga catctgccgc taaacaaaac caagaacctg 1025701 tacctgatga taccgcggtt attttatata cgtcaggaac gactggaaaa ccgaaaggcg 1025761 cgatgctgac acatcagaat ttgtacagca atgccaacga tgtcgcaggc tatttgggaa 1025821 tggatgagag ggacaatgtg gtctgcgctc ttcccatgtt tcacgtgttt tgtttaaccg 1025881 tctgtatgaa tgcaccgctg atgagcggcg caactgtatt gattgagcct caattcagtc 1025941 cggcatctgt ttttaagctt gttaagcagc agcaggcgac catttttgcc ggtgtgccta 1026001 caatgtataa ctacttgttt cagcatgaaa acggaaagaa agatgatttt tcttcgatcc 1026061 ggctgtgcat ttcgggaggc gcgtccatgc cagtcgcgtt gctgacggcg tttgaagaaa 1026121 aattcggtgt taccattttg gaaggctacg ggctctcgga agcatcaccc gtcacgtgct 1026181 ttaacccgtt tgacaggggc agaaagccgg gctccatcgg gacaagtatc ttacatgtcg 1026241 aaaacaaggt cgtagatccg ctcggacgcg agctgcccgc tcaccaggtc ggcgaattga 1026301 tcgtgaaagg ccccaatgtg atgaagggct attataaaat gccgatggaa acagagcatg 1026361 cattaaaaga cgggtggctt tatacggggg acttggcaag acgggatgag gacggctatt 1026421 tttacattgt tgaccggaaa aaagacatga tcattgtagg aggatacaat gtgtatccgc 1026481 gggaggtgga ggaggtgctg tacagccatc cggacgtcaa ggaggcggtt gtcatcggcg 1026541 tgccggaccc ccaaagcggg gaagcggtaa agggatatgt ggtgccgaaa cgctctgggg 1026601 taacagagga ggacatcatg cagcactgcg aaaagcatct ggcaaaatac aagcggcctg 1026661 ccgccattac gtttcttgac gatattccga aaaatgcgac ggggaaaatg ctcagacggg 1026721 cactgagaga tattttgccc caataaaatg aaaaagcgaa gcggttagct tcgctttttc 1026781 attttcaatc ctttgcttct tttttaataa tatttagcag cgcctttgta tcatttttgc 1026841 ttaatttgta gtatgtgcca tccttcaaaa aaacggcttg ctggctgccg tcaatccata 1026901 gtctgaatga gtcataccgg tctttatgaa acttgattgt cccttcgtaa tcaggggctg 1026961 atgttttttc tgtcttcacc tgttttccct gattcataat atccagcata tctttgacgt 1027021 gctgtctttt ttcaatctcg atatcttcct ggccgcttga agacagtgtg atcaaatccg 1027081 cgtctaccga ttgatacaca tcgcctgatc ggctgtaaag ataaaaaaat gcgataaaca 1027141 caagaccgat taccacgatg gctgccacta tttttttcat ttgcatcact ccaaacattg 1027201 ttagttttcc cagcgatcgg ggtttccatg cttaaaaggg tggaaaagtg cggaacacag 1027261 cttggttcta agaatttgaa tttatgatta caatagaagt aacgggttga tgtgaggagt 1027321 gaggcgttat gcgcaagtgg attgcggcag caggacttgc ttacgtgctg tacgggctgt 1027381 ttttttattg gtattttttc ctgtcgggtg attccgcaat accggaagcc gtgaaaggga 1027441 cgcaggctga tccggcttct ttcatgaagc cgtctgagtt ggcagtggcc gagcagtatt 1027501 cgaatgtcaa gaatttttta ttttttatcg gggtaccact tgattggttt ctgttttttg 1027561 ttctgcttgt cagcggtgtt tcaaagaaaa tcaagaaatg gatcgaagcg gccgtgcctt 1027621 ttcggttttt gcagaccgtt ggttttgtgt ttgtgctttc gctgattaca acattggtga 1027681 cgctgccttt agattggata ggctatcaag tatcgcttga ctataacatt tccacacaga 1027741 caacggccag ctgggctaag gatcaggtta tcagcttttg gatcagcttt ccaatcttta 1027801 cgctttgcgt tctcgttttt tattggctga tcaaaaggca tgaaaaaaaa tggtggttat 1027861 acgcctggct gttaacagtg ccgttttcgc tgtttctgtt ttttattcag ccggtcatta 1027921 tcgatccttt atacaatgat ttttatccgc tgaaaaacaa agagcttgaa agcaaaattt 1027981 tagagctggc agatgaagcc aatattccgg ctgaccatgt atatgaagtg aacatgtcag 1028041 aaaaaacaaa tgcgctgaat gcctatgtta caggaattgg ggccaataaa cggattgtat 1028101 tgtgggatac gacgctgaac aaacttgacg attcagaaat tctgtttatt atgggccacg 1028161 aaatgggcca ttatgtcatg aagcacgttt acatcggtct ggctggctat ttgctcgtgt 1028221 cgctcgccgg attttatgtc attgataagc tttacaagcg gacggttcgc ctaacccgca 1028281 gcatgtttca tttagaaggg cggcatgatc ttgcggcact tccgctgtta ttgcttttgt 1028341 tttctgtttt gagctttgcg gttacgcctt tttctaatgc tgtctcgcgt tatcaggaga 1028401 ataaggctga ccagtatggg atcgagttga cagagaacag agaagccgct gttaaaacgt 1028461 ttcaggattt ggccgtgacg gggctgagcc aggttgatcc tccggtgctt gtgaagattt 1028521 tcagaggcag ccatccgtcg atcatggaac ggattcaaca tgcggagaaa gaagagaatg 1028581 cgccggaaca tcaggatgct gacaaataaa aagaagcagg tatggaggaa cctgcttctt 1028641 tttactatta ttgtgcagct gcttgtacgt tgattaaccc ttttccatag tagaaagagt 1028701 ttccaagata tgttgcagtg ctttctaaac gatcacggac ttgcgcgttt gtccaagtcg 1028761 ggtgcttaga aagaattaac gctgctgctc cggcaacgtg aggagtcgcc atggacgttc 1028821 cgttataagc gccgtaagtg cctccaggaa gtgtgctttg gatggacacg ccaggagcca 1028881 tcacatcaag ctcagaacct gcgctggaga atgaagctct ttggttgctg ctgtttaccg 1028941 cacctactgc aatagtagaa ggatattttg cagggtagcc gactgtgctt gtgcttccgg 1029001 atgaaccttc gtttccggct gcggcagcaa cgacgatacc gctggaaacg gctttgtcaa 1029061 cgactgtttt cagcgctgta gaaccagtag gtccgccaag gctcatgttg ataacatcca 1029121 tattgttgga aatggcccac tcaatgccgt taataatcca gctatattgg ccgcttcctg 1029181 ttgaatcaag cacttttact gcatataatg atgcgcttgg cgctacgccc agaacaccga 1029241 ttgagttatt aagagcggca atcgtaccgg ctacatgcgt accgtgagaa ctgccgtcct 1029301 ggtatgggtt tgtttcagaa ggtacgaagc ttgctccgcc tctgacgttt aagtcaggat 1029361 gagaagagtc aattccgctg tcgataacag ctacttttac gttagagcct gtgtagcctt 1029421 gagagtgaag agccggcgct ttaatttgag aaatgccata aggaacagat tgcgcatatt 1029481 catgtgcaat atgatcttct tccacatatg caacgctcgg atcttttttc aattctttta 1029541 cagctttttc atccaatgtt gctgcggccg cgttaacata cttaaattgc ttttgaacct 1029601 ttccgccttt ttcagaaata acatcctttt tcttggcgga actcatggca ctcattgtct 1029661 gtttaaatcc gacaatgtat ttcttttctg tactgctttt tccggcagcc tgcgcagaca 1029721 tgttgctgaa cgccatcgta aagattaacg ttaacgcaaa caacaagctg atccacaatt 1029781 ttttgcttct cactctttac cctctccttt taaaaaaatt cagagtagac ttacttaaaa 1029841 gactattctg tgaatttatt gtaatagatg gaataatatt ttagtagacc catttttttg 1029901 agatgatttt atctctattt aggtatatca tctctcgcta tttccgtaga gactcgaaat 1029961 aactattttc atacagaaaa gaacgaaaat agacatgagt aaatgttcat tatgctgaaa 1030021 tgtcatgctt ttttaggtta aatgctcctg agtcccggca aattcctgtc gaaaaaattc 1030081 gttcaaatga cctgcgtgtg cttccgtgag aacaatggat attatcgtga tattttttca 1030141 aagcatgatg ataaaagtat tctgaaaaat aaactttaca gaaaagggat agaatgaaaa 1030201 aattattgag agggaggaag aaataagatg aacattcgcc aagcaaagac atcagatgcg 1030261 gccgccattg cgccgctgtt taaccaatat cgggaatttt atagacaggc atccgatttg 1030321 caaggggcag aggctttttt gaaagctcgt ttggaaaatc acgagtctgt tattttgata 1030381 gcagaagaaa atggagaatt cataggcttt acccagctct atccaacgtt ttcttctgtg 1030441 tcaatgaaaa ggatatacat attaaatgac ttatttgtcg ttcctcatgc gcgtacaaag 1030501 ggagccggcg gccggctgct ttctgccgca aaggattatg cagggcaaaa cggggcaaaa 1030561 tgtttaacac ttcagactga gcaccacaac cggaaggcaa gaagcttgta tgagcaaaac 1030621 ggctatgaag aggataccgg atttgtccat tattgtctca atgtgccggc gaagtgaaaa 1030681 tggcggcttg atgatttggt tttttgaacg ttcttcggtt acgatataaa tgaaaaggag 1030741 tgtgccgaat gtcaacgtta tttcaagcct tgcaggcaga aaaaaatgcc gatgatgttt 1030801 cagtccatgt gaaaaccata tcaacagagg atttgccgaa ggatggtgtc ctgattaaag 1030861 ttgcttattc cggcattaat tacaaagatg gtctggccgg aaaagcagga ggcaatatcg 1030921 tcagagagta tccgcttatt ttaggcattg atgctgcggg tacggtcgtc tcttccaatg 1030981 atccgcgttt tgcggagggg gatgaggtga tcgcgacaag ctatgagctc ggtgtctcac 1031041 gtgatggcgg attaagtgaa tacgcttcgg tgcctggtga ctggctggtg cctttgccac 1031101 agaatctttc gttaaaagaa gcgatggtgt acggaacggc gggatttact gcggcgttat 1031161 cagtgcatcg gcttgaacag aacggtctgt ctccggaaaa aggcagcgtg ctagtcacag 1031221 gagcaaccgg cggtgtcggc ggaattgcgg tatcgatgct gaacaagcgg ggttatgatg 1031281 tggtggcaag taccggaaac cgggaggcgg ctgattattt gaaacagctt ggtgcaagcg 1031341 aagtaatcag cagggaagat gtctatgacg gaacgcttaa ggcgctgtcc aagcagcaat 1031401 ggcagggagc ggttgatcca gtcggcggaa aacagcttgc ctcgctttta agcaaaattc 1031461 aatacggcgg atctgtcgca gtgagcggct taaccggcgg aggagaagtt ccggcaaccg 1031521 tgtatccttt tattcttcgc ggagtaagcc tgctcggaat cgattcagta tattgtccga 1031581 tggacgtcag agccgctgtt tgggagcgca tgtcttctga tctcaagcct gatcagctgc 1031641 tgaccatcgt ggacagggaa gtatcattgg aagaaacgcc gggtgcgtta aaagatattt 1031701 tgcaaaatcg cattcaagga agagtgattg tgaagcttta acaggatcag cttgcagaga 1031761 atgttatttt tctgcaagct tttttgtgga caggatgatc agctgctgaa ctgctgtgtc 1031821 gcgaaacaag attttcctgt aagccgaact ttctcttctc attttaaaaa taattggtga 1031881 taatgattct cattccgtgt tatactactc ttggacatct taaccataga aactaccaac 1031941 aggagagact ggaacatatg aaaaaaacac tgattattct tacagtttta cttctttctg 1032001 tcttaacggc tgcttgctcg tcttcaagcg gcaatcaaaa cagtaaagaa cataaagtgg 1032061 cggtaacaca tgatttaggg aagacaaatg tgcctgagca tccgaagcgg gttgttgttc 1032121 ttgagctagg ttttattgat acactgcttg atctcggcat tacgcctgtc ggggttgccg 1032181 atgacaacaa agcgaagcag ctgatcaaca aggatgtgct gaagaaaatt gacggctaca 1032241 catctgtcgg cactcgctca cagccaagca tggaaaaaat cgcttcatta aaacccgatt 1032301 taattattgc tgacacgacc cggcataaga aggtgtacga tcagctgaaa aaaatagcgc 1032361 cgacgattgc acttaataat ttaaatgctg attatcagga tacaattgac gcttcgctta 1032421 cgattgcaaa agcagtcggc aaggagaagg aaatggagaa aaagctgacg gcgcatgaag 1032481 aaaagcttag cgagacaaag cagaaaatca gcgcgaacag ccagtccgtg cttttgatcg 1032541 gaaatacaaa tgataccatt atggccaggg atgaaaactt ctttacatcg agacttttaa 1032601 cacaggtcgg ctaccgatat gcaatcagta cgtcaggcaa tagcgattca agcaatggcg 1032661 gcgactctgt gaatatgaaa atgacactgg agcagctgct gaaaacagat ccggatgtga 1032721 tcatcctgat gacaggaaaa acagatgacc tcgacgccga cggtaaacgc ccgatcgaaa 1032781 agaatgtcct ttggaaaaaa ctgaaggcag tgaaaaacgg gcatgtatac cacgtggatc 1032841 gtgcggtgtg gtctctgcgc cgcagtgtag acggggcgaa tgccattttg gacgagcttc 1032901 aaaaagagat gccggctgct aagaaataaa agaaaagaca ggcaaacgcc tgtctttttc 1032961 ttatttgata aagccggata agtggctgtt gatattatag tcttttatcc gccatttttc 1033021 ttctgcaaat tcaatgttgc tgaggcaggc gttgacgaga cgggtgcttt gaagctccgg 1033081 gtcaccgccg gatatttctg tcagcagggc gtgaattgcc gcaccgtgcg ccacgatcag 1033141 caccttcttg tttggatacg cctgattcac ttttgccaaa ccgcccatca gcctgtcagt 1033201 gagttcttct aaggtttcca tattcggata gatgttatct ggatagcgct ttgtccgttc 1033261 ctccagcggc atgccctccg cgtcgccgta atcgcgttcc ttaaaatcat ccatctcgac 1033321 tatcggaaga tgcagatatt cattaataat ttccgcggtt cttttcgctc ttttcagcgg 1033381 gctcgtcaca ataatatccc aagaaaagtc ctttacatat tctccggttt ctcttgcttg 1033441 gcgttcacct gttgcgttta gcgggatatc ggttttgcct tggcattttt gctgcaggtt 1033501 ccaatcggtt tctccatgtc ttactaaaca aacggctgtc ataaaatccc cttcctgact 1033561 ttattcatat cgctattata ctaaatcgaa agcgtgtgtc ctatgaaaaa gcctatgcaa 1033621 gaacttcaaa taataaagcc agtccgattc cgccgccgct tccgatggct gcaacagcat 1033681 attgacagtc tggccgtctt ttcgcttcat aaaacaatct ggttaccaga gctgcacctg 1033741 atgcaccgta cggatggcca agagctaagg cgccgccgcg cacattgatt tttgaaaagg 1033801 gaatgccgag ttcttgcgag cagacacaaa ttttgacggc aaaggcttca ttgatttcaa 1033861 ataaatcgat atcatcaggt gttacatcgt gtgtatgtaa gagctgacga atcgcgacaa 1033921 ccggtgccgc gggcggaaag ttggggtgaa tgccgctgac agcgctgccg ataaaccgaa 1033981 gcacaggctt aagtcccagg gctgctgctt tttcttcttc cattaccaaa agagcggctg 1034041 ctccgtctgc tatgccactg ctgttggctg ctgtgactgt tccggagctg gtgtcgaaaa 1034101 ccggctttgc acggggaata atcgcttcta ttggccgcgt tttcaaaaat gcttcgtccg 1034161 tctccaattc cccgagagca acaacttctt cacggtaaaa tccttcatca tgcgcgttcc 1034221 tgctgcgttg atggctgaga agcgcgtact catcctgcat gcttctgctg atggaatagc 1034281 gtgcagccgt atattctgcc gcaatgccca tgtctggatc gccgatcgca tctggagaaa 1034341 agcgagcccg ttctgaaaaa ggggattggc tgctgctttc tgagccgccc gcgatataca 1034401 tcgtgccggc tcccgcttga ataaggctgc aggcatagcg cacagcttca aggccggagc 1034461 cgcactgtct gtcaattgtc attccgggaa ccgataaagg cagtccggct tgaagggctg 1034521 acagtctggc caggttgccg cctctgccag tagcgtttcc gagaatgacc tcgtcaactt 1034581 gatcctctag ctttcggctg agacagcgga tgatgggagc cgccaaatcc tccggcagga 1034641 agggcttcag cagtccgttt tgatttccaa agatcgttcg ttttgcatca acaataaccg 1034701 cattcattta tactgtacac tctcttccag ccattttttc actctggaac gggcaatttt 1034761 tccgctgctc gtttccggca agctgtctgc aaacacccat tttttcggaa ttttatagga 1034821 ggctaatttc tgtttacacc aggctttcag tgttctggca ttagcgtttc caagaatgac 1034881 agctacagcg atttctcccc aatactcgtc gggaatgcca acgacagccg cgctttcaac 1034941 ctctgggcag gcgagaagca cacgttcaat ttcttctggg aaaatattta atcctccgta 1035001 cacgatcatc ccgttttctc ttcctgatat gtatagaaag ccctcttcat caacgtagcc 1035061 catatcatct actgtcatcc attcatctgg tgtgctgccg ttcacatagc cggaaaacct 1035121 catcgggctt ttgacaaata tttttccgat ttctcctggc tggcagcgtt ctcctccagc 1035181 gttgcggatt tcgatccgga cattatgaaa agggcggccc gctgaatgcg gcttccgttt 1035241 gctgtcttcc ggtgaagaaa acgtcacaaa actaagctct gatgtgccgt aaaaatcgta 1035301 cagcttgaga tgaggccatg cagcggcaag cttcttcttg gattctgccg gccagtctgc 1035361 gccggatgaa atgattttga cgggactgtc gggaaaaccc tcaatccttg cgagggcgtc 1035421 tgtcatcgtc ggtacggtat agagaacact gatggattca cggcacagcc attccttcgc 1035481 tttggcagga gaaaactttt tcagcaaaca aacggttcct ccgagaaaca aagtgctgac 1035541 agccccatat aggaagtgag aggacattaa cgctccggga atcagaacct tatcatctga 1035601 tgaaatcgaa aaatctgttt ctgtacaggt aaagctctcc atccatgagc ggtgagatcg 1035661 cgtaaaggcc ttcggttttc ctgtcgagcc cgacgtaaat cccatataaa aagggtgctc 1035721 cggatcaatg gtaggcaagg gatcagcggc tgcctcagaa atatctgcca tacagttatc 1035781 cagcaataca acaggtgtct ggctatctgt cagtttgttt ttgaaaaagg ctaaagtaac 1035841 cacaagatcc gcattgctta tggacagccg ctccttacat tcagccgggc tccagcgtgt 1035901 gtcgatggga atggccgtac atccagccgc tgcggctccg gcaaacagct gtaaaaacgc 1035961 gagactattt gggagcagga tcgccacacg attcggcatg ctcggctgtg accgcagcca 1036021 atttgcggtt tgagagacaa gccgatccca atcatggtac gtgatttgct ccgattcagt 1036081 ctggatcgct acacggccgg gcgatgtttc ggcagtagat gaataggtat gagtaattgt 1036141 catgtattgt catcctcctt ttgtaaacat cgtatcagaa agagacaagg cttgagtgat 1036201 ttttatcgcc agaaatgcag atacagccgc ttttatcaaa tcaccaggca catatgcaag 1036261 gctcatgaag gcggcctgtg acaaatcaat atgcatgata aaagcttgta ccggtatacc 1036321 aagcagataa ataaagatga tgccgaatac gatatgagtg aaaaagagac gcaatactgt 1036381 caccttccgc agcctgttag cggctaaact gatcagccat gaagcgaggg gataagcaat 1036441 caaaaagcct gcgctcggtc cgaaaaacac accaaaaccg cctcgtccgc cgggcaacag 1036501 cggcgctccg aaggcgacga gcagcaaaaa gacaagctgg cttaagaaag cagactttgg 1036561 cctgagaatg ctgcctgcca acatgacacc aagcgtttgc aatgtaatcg gaacgggtgt 1036621 aaaggataag aagagagggg gcataaagcc gagcactgcc atcagcgcgg tgaaaatcgc 1036681 aatatgcatc atgtcgatta atttcagcat gtgaaatcct ccaaaaagta atcaaatatg 1036741 gttatacaat aaatgcaggt aattattatg tcaactgatt tttaatttaa gtttacataa 1036801 tgaacgcaaa aaaaccggcc gtatggcaga ccggtttttg atggttattc ttctgtcagg 1036861 atgacaagcg aatcaacgga agcggccaca tgggaaacgg cgcggctgac ttcctgaagc 1036921 cctccaagaa aggcttgcag atcgacgtcg attttgcctg attgctcttt gctgattttc 1036981 atgctgtgga cgatttcatc gaataagcgg ttaatttgcg tcattttttc tttactttcg 1037041 ctgactagct cattcacgtc tttgatatgc ttggatacaa tgttgatttg tgtattcgta 1037101 ttgttcacaa gctcagaaac agtagagacg gtttttttcg tatcctcaga aagcttccgc 1037161 acttcatttg ccacgacagc aaagcctttg ccgtgttctc cggcgcgggc ggattcaata 1037221 gatgcattga gcgagagaag gtttgtttgt tcagctatgc ctgtgacgat gccgaagatt 1037281 ttttcaattt gctgcgcgat ttcatccagc ttgaccattt ctttttcgat ttggacaagg 1037341 cttgtgtcaa ttttgttcat ctgtttttgc tggacttcta gctctttttt tccgccgatc 1037401 gacttttctt caacagtgct ggatgttaca gtgccggctt tggatgcttg agaaatgcct 1037461 tcagatttgt ccacaagctc ttgaactgat ctgcttgttt ctgaaaacag attggcaatc 1037521 gatccagagg tttcttgaat tttctgatga agaaggtttt tcttttcttc ttgttcatca 1037581 cgggtctggt tgtactcgct ttgaaacgct tcaaggacaa gctgctgttc taagttcaag 1037641 atttttgttg ttgctttaat ggcttttagc agttcttgct gatttgtaat ggacgcttca 1037701 taaatgtcaa tcattgacaa aaggagctct tgaaacgcac ccatatacca ttttggcaaa 1037761 aggccgattc ttaaatggat ggaggcgatt cggttacgct tttcaataaa ttcatcatcg 1037821 ataacgcctg caaacatttc ctgaatatgc cgttttaacg tttgttttaa gcggtcaact 1037881 gagctgtgat cattaatgat atccatcaat gagctttcat ggtcaaggtt tttataaaac 1037941 gcatcgacga tatttacgat attttcttga atgagtggct gaagctgctc taacacataa 1038001 agctcagcat ctcccaacct gaccattttg agctgttttt tgacatctgc atgtttgttt 1038061 gtgagctgaa tgcggttttt ttgttgtccg tttgaatctg aaaagtaagc tgtttcttgt 1038121 tttctgtctt ttttaaataa caatacaatg atcccccttg ggaaaaatat aatttttact 1038181 ttttggcttt ttaagccttt ttctttttta tcggccaagg gaaacatgaa tgaagctgca 1038241 gatgaaaaat atttgaaaaa acgttcatta aaatgaacgg tttaatcgag atctatttgt 1038301 tttaatggtt taatggccgg accctctaca acttcgccag atggcttaaa gcgtgatccg 1038361 tggcacggac aatcccacgt atgctcactg tcgttccact cgacctcgca gcctaaatgg 1038421 gtacaagtcg tatcaacgag atggaggcag cctgtctcat cacgaaatgc tcccgctcgc 1038481 ctgccgttta tggtgacggc tttcccttct cctggcgaaa tgtcttcaaa ttggacatca 1038541 ggcttttcaa gctttccttt tatcaaatgc ttggcgacat ctgcattgta ggaaatcact 1038601 ttctgcaacc cgggattcag atggaaacgg gacggcgtga aaatgctttc gtatgggttt 1038661 tcttttttct ccacaaggtc tgacaataaa gtggctgcga ctgctgagga cgtcatgccc 1038721 cattttttga acccggtcgc tactagaata ttgtcctcat tttccgacat cggcccgata 1038781 aacgggattt tgtcgatcgt cactagatct tgggtggacc aataatatgg aatgctttcg 1038841 atgccgatgg tgctttcggc cagttgtctc agtgtttcat aatgtgtaga catggctttt 1038901 ccctggcctg ttttatggct tactccgctg aagagaatca gcttttcacc gtttacaacc 1038961 gtatagcgga gcgccactga cggctgatcg atactcaaat acatgccctc gggatactcg 1039021 atcttcggct tgatggcaag gacataagat ctgtcggagt acattctcgc agcatataat 1039081 ccgcctccgt cataaaaagg gaagtgggaa cagcatatga taaagcggct cttaatggcg 1039141 tgccggcttt ttgttaccac ttcgggcctt tcgccttttt tgatatcaag cgcaacggtc 1039201 tcttcataaa ttcggccgcc tttttgaaca atttgctcca gaagcgcttt taagtattga 1039261 agcggatgaa attgagcttg attcttcatg acaagcgcca gcttagaacc taagggaatt 1039321 ggaagatcct tgataaggtc tctttcaatt ccgagctttg tgtatgcctc atgctcggtg 1039381 tggatttttt gaacagcgtt ttcatttgcc gtataaagat atgcgtcttg ctcgatccat 1039441 tcacaatcaa tttgatgttc atccacaatg ccttttatgt aatcaattgc gttttggttt 1039501 gcttcataat aaagcctcgc atggtttaat ccgaaatggc ggataaattc gtcgtatatc 1039561 atgtcatgct gtgcggtaac tttagcagtt gtatgcgcag tggttccgtt aagaacctga 1039621 tttgcttcaa tcaaaacgac acggaagcct ctcttcgtaa gttcatatgc cgttgtgatt 1039681 cccgtaatcc cgcctccgat aatggtgacg tcacattcag tgtcctcttg aagcgcagga 1039741 aaagaaggca ggtcagttga tgttttccag tatgtttcag gtgcttcctt tgcaaaatgt 1039801 tgattagcca agccgttata cctccaatca gatttattct taatttttcc atattctatc 1039861 ttttcataca taggaagcag gcattgttca taacataata aggttgaaaa ggagtgattt 1039921 cattggcgaa tcaaaaaaag aaaacattac cgcctcagca ccagaaccag cagcctggtt 1039981 ttgaatatct gatggacccg cgtccggttt ttgataagcc gaagaaagcg aaaaaattag 1040041 agggcaaaac cgctattatt actggaggag acagcgggat tggacgcgct gtctcggtgt 1040101 tattcgcaaa agaaggggct aatgtggtca ttgtgtattt gaatgaacat caggacgccg 1040161 aggaaacaaa gcagtatgta gaaaaggaag gggtaaaatg cctgctgatt gcaggagatg 1040221 tcggggatga agcgttttgc aatgatgtgg tcgggcaggc aagccaagtg tttccatcca 1040281 ttgatatatt ggttaacaat gcagctgagc agcatgtcca gcccagcatt gaaaaaatca 1040341 ccagccacca gctgatcaga accttccaaa caaacatttt ttccatgttt tacttaacaa 1040401 aggcagtgct gcctcattta aaaaaaggga gctctattat taataccgct tcaattaccg 1040461 cctataaagg caataaaacg ctgatcgatt attcagcgac aaaaggcgcg atcgttacgt 1040521 ttacaaggtc cctttcccag tcgcttgttc agcagggcat acgggtcaat gcagtggcac 1040581 cgggtcccat ttggacaccg cttatcccgg ccagctttgc cgcaaaagac gtggaagtgt 1040641 ttggttcaga cgtgccgatg gaacgcccgg ggcagccggt cgaagtggcg ccaagctatc 1040701 tataccttgc cagcgacgat tccacatacg tcacagggca gacgattcac gtcaatggcg 1040761 gaacaattgt gaacggataa taaaaagcca atccttgaag gattggctta ttcgctctgc 1040821 ttgagcgctg catattcttt agagagcgta agaaacgcat ctttatcttt ttcgtccaag 1040881 gctttgttaa tttggtccgt cagcatggca agccgacggt tatacaagga ttcatcgagc 1040941 accatttgaa tgtaaatatc cgtcattgtg acatcgaatt cttttgtttt ttgcgtgttg 1041001 cgggacttca tgagctcagt gtacgatttt ttctctttca taaagaatcc ccccaatgcc 1041061 ttttttatag tatatggata acggtcgaaa aaatcaataa atttttataa tttttagaca 1041121 actaatactt ggcaatctat cgacatatcc tgcaaaatgc cgtaaaccgg caagtcttat 1041181 gaaagtaaaa tcggtttatt actagtcatt tagtaccatt aaatatcatt aaaagatgat 1041241 tttatcttaa atgttaaaaa aacctgtcgt tttacaaaaa cagatgatag attattagta 1041301 taaattttgc agaaaaagga tggaggccat aatatgagtc agaaaacaga cgcaccttta 1041361 gaatcgtatg aagtgaacgg cgcaacaatt gccgtgctgc cagaagaaat agacggcaaa 1041421 atctgttcca aaattattga aaaagattgc gtgttttatg taaacatgaa gccgctgcaa 1041481 attgtcgaca gaagctgccg attttttgga tcaagctatg cgggaagaaa agcaggaact 1041541 tatgaagtga caaaaatttc acacaagccg ccgatcatgg tggacccttc gaaccaaatc 1041601 tttttattcc ctacactttc ttcgacaaga ccccaatgcg gctggatttc ccatgtgcat 1041661 gtaaaagaat tcaaagcgac tgaattcgac gatacggaag tgacgttttc caatgggaaa 1041721 acgatggagc tgccgatctc ttataattcg ttcgagaacc aggtataccg aacagcgtgg 1041781 ctcagaacca aattccaaga cagaatcgac caccgcgtgc cgaaaagaca ggaatttatg 1041841 ctgtacccga aagaagagcg gacgaagatg atttatgatt ttattttgcg tgagctcggg 1041901 gaacggtatt agaaaaatag gaaggagctg accgaacagg gcagctcctt tcataaagct 1041961 atgccgtcgg aattcctccg gtgatgccat atacctgaga tgtcacatag cttgaattct 1042021 ctgaagctag aaatacataa acatcggcca attccactgg ctgcccagcg cgatttaatg 1042081 gagctggcgg cgtgccttgt ccgaatttcg ggatgttttc cgtcggctgt ccgccggaaa 1042141 tttgcagcgg tgtccaaatt ggtccgggcg caactgaatt tactctgatg cctttggaag 1042201 caagctgttt tcccagtccg acggtaaagc cgataatggc gtttttcgtt gctgcgtaat 1042261 ctaacagcat cgggcttgga ttatagcctt caactgaggt agttgtgata attgaagctc 1042321 cctccggcaa atacggaagc gccgctttta caacccagta aagggaaaag acgttcactt 1042381 caaatgtttt atagatttgt tcagtaggca gatcttcgat gttttcgacc gcttgctgtt 1042441 tgcctgcaac gagcgctagc acatcaagtc cgccgagttc gtgatgcgac tgtttgacta 1042501 gatcttggca aaaggattcg tcgctcaagt ctccggggat cagcactgct tttcggcctt 1042561 ctgcttcaat cagctctttt acctcttcag catctggctg ttcctcgggc aagtagttaa 1042621 tagccacatc ggcaccttct ctggcgtaag caattgcggc agcgcggccg ataccggaat 1042681 cgccgcccgt gacaagcgct tttcgacccg ttagtttacc tgatcctttg tagctttttt 1042741 ctccgcaatc agggacaggc ttcatgttct tttgcaggcc tggcggttct tgatattgtt 1042801 cgggaaattc atcatgaaaa aatgctttta taggattcgt aagatttgaa tcagacatca 1042861 gcaacgctcc ttttctgttt ggtgtacatt cgtatgtgta cccctgagca taagcagaaa 1042921 aacatgtttt ggcagtttga atagtgaagg aaaaagaaaa caagaaaaaa caaagccttc 1042981 ttccatattt atcttgtcaa ataagactat atgaattatg ataaattcga gctataaatc 1043041 aactaaatat tgggtgttgg gagagtgaat cgtcatgaaa aaagcggcgg cggttttgct 1043101 gtcactcggt ctcgttttcg gtttttcata cggagctggc catgtggcgg aagccaaaac 1043161 aaaggtgaag gtctataaga actgcaagga gctaaacaaa gtatacaaag gcggagtggc 1043221 ccgcacatcg aaggtgaaaa acaaaggcgg aaaaacgaag tacaagcctt acgtttctaa 1043281 ggcactttac gatgccaata aaaacaaaga ccgcgataaa gatcttatcg cctgtgaacg 1043341 gtaaataaga aaaagcaatc tggtgtccag attgcttttt ttatgcttag gccgcctgat 1043401 cggccgcagc gcttttcgcc ttccttgtca taaggctgac tgccatcatg accgtgatat 1043461 tcaaaagcag ggcgacgatg ccgacattca agtcttttgc ggcttgcggc agagccggaa 1043521 ataaagtgcc gatcgtcgtt tccgtcattg taatataagt aactgctccg acacctgcaa 1043581 taatgccggc gaaagctcct tgctttgtca ccatattatg cttgagcagg ctgaacaaaa 1043641 gggcggggaa tagctgtgtg acaaggctgt agcccatcaa aagcagcgta acgatggtat 1043701 tcccgccttt gaaggtaaaa tacaccgaaa tcagcgcaat caccggcact aaaaacttag 1043761 caagcgccga tacttgctgt tctgtcgtgc ggggcgcgat taccttgtac acattttttg 1043821 caaacagtgt ggaggcggac attaagatca tagaccctgg cacaagtgct gtcagcagtc 1043881 cggcagcacc gataattccg acaaaccaag ggtcaaatgc ttgcagagac agtctcaaaa 1043941 gcgacaaatc cccgtctgcg ccattcagat ctggaacttg caggatagcc gcaaagccga 1044001 cgaaaaggac gaagagcagg accagctggt acaaaggcat gatgatggcg tttttacgaa 1044061 acacttttgg gttttcggct gaatacgaag cggaaaacgt gtgaggccac atgtaaaaac 1044121 caagcgctgt caagagtacg gttgaactga accaggccac actttgtccc gattcgggga 1044181 gcgtaagaaa gccaggcttt gccgtttcaa tctgctgaaa catgtcttga aatccgccgt 1044241 agtaatgaat tggcaaatac acacctaaaa acagaacgac aaccagaatc atgatgtcct 1044301 tcacaaccga tatccaggca gacccgtgaa tgcctgaaac cataacataa accgtgatgg 1044361 aaacagcgcc gatccagatg gcagcggtcg gggtgatttt gccgtacgag gtttccgata 1044421 caatcagccc gaggcctttc agctgcagta caagataggg aatgagtgcg gcgatgccga 1044481 ccagtgaaac gagaatgcca agcagcggac tgttgtattt ttttgtgaaa aaatcagact 1044541 gcgacatcag tttatgctgt ttcgcgtacg tccaaactgc tggaagaagc cagtaagaaa 1044601 ggatgtaggc cagacatccg taggcgatga tataaaaggc tggaccgcct tttccgtagg 1044661 cccagccgct gccgccgaga aacgtaaaag tagtataaat ttcgcctgcc atcaaaagga 1044721 agacgaaaac agttccgaag ccgcgccctc cgaccgtcca ctgctccagg ttcatgtctt 1044781 ttcctttttg ggcgcgtata ccgagaaaaa tactcaagag caggacaccg aagatgatga 1044841 tgagagctgc attcattctg cttcctcctt tttattttcc ttgtcgagga catacacaat 1044901 cgccatcagc gcagaggtca aaagagccca catcacaata taggcaagaa taaacggcat 1044961 gccgaacaca tagggggtca ccttatttgc aaaagggatg ccgagtaaga ttccgataaa 1045021 gggtaaagcg gcaagaacgt gaatcagttt catagaatcc tccttctatt taggattgag 1045081 gtgtacaagc ctaagcgtac tgaaaatgat gtcgcagata tcgcagcaca tgtcattttt 1045141 tggagtgaaa ggctgtggtt cgaattataa ataaatttat tttgtttgta tagtgtgaat 1045201 tgtctgaaat taatgctctg aatcgcccga agagggaacg ggcagtatga ttcaaaaggc 1045261 tcagagtctg tctggggcaa atagatagta tgttaataat tcgctgacct gctcacggat 1045321 tcgcggatta aaatagcgat ggttttcttc ataaccgtcg atgacaaatg tatagagtgt 1045381 aaaggcctca tcgcgttccg tctcgcggat tgcaattttt cttttcctca gttcttttct 1045441 gacctccatc aaatcctttt gtgctatttt taatgattcg ctgataagct gtttataagg 1045501 atgcttcaat tttaatgtgc tttcttcaat tccggcgaga tcacggttaa aaatcgtaat 1045561 ggccatgggc aaaaagagag cccgttcaat taaatcgtat atttcctcct gcagatttgg 1045621 catattgact ccttctttct aagggaacgt ttgttctatt tgtattctat atcggctggt 1045681 gaaatgtttc aagacagaaa aaatcaccaa aactttttag ttttctgctg ataatgtgta 1045741 gaataaggat agacaaaccc ggtaaggagt ataaatgttg gagcattttt tatcctattt 1045801 gacacaagaa catttaactg aattatttca aagctatagg gctttcggtc cgctcattgc 1045861 tgtgctgctg cctttaattg aagcatttct cccgtttttg ccgctgatcg tgtttgtggt 1045921 ggcgaatacg aactcgtttg gcttgtggga aggattcatc ctatcctggg cgggatcaac 1045981 tgctggttcc attctcgtct ttttgattgt ccgtcaatac ggacagagaa aattgcttgg 1046041 atttatccgc agtcatccgt ctgtcagaaa gctgatgtta tgggtggaaa gacacggctt 1046101 cggtcccatg tttcttctgc tttgttttcc atttacaccg tcagccgcgg tgaatgttgt 1046161 tgccggtttg tcaaggatcg gaacgcggcc gtttattttg gcggcagcct cggggaagct 1046221 tgtcatgatt tttatgatca gcttcatcgg atatgatctg cacgcgctga ttacacagcc 1046281 gattcgaacg gtcatcgccg tattggtgat cactgtctta tggtatgtcg gcaaaaaggt 1046341 ggagcggtat ctgcatgtaa gagccagtca gcgtgagcat gatggaggga gacagtaaca 1046401 tgaaaaaacg gttttggttt cttgccggtg tagtgtccgt tgttctcgcc attcaggtta 1046461 aaaatgctgt ctttattgat tacaaggtag aaggcgtcag tatgaacccg accttccagg 1046521 aaggaaacga attgttggtc aataaatttt cgcatcgatt taaaaccatc catcgttttg 1046581 acatcgtcct ttttaaaggc cctgatcata aagtgctgat taaacgggta atcggcttgc 1046641 ccggtgaaac gatcaaatat aaagatgatc agctgtatgt gaacggaaag caggttgctg 1046701 agccattttt gaagcatttg aaatctgttt ctgccggcag ccatgtaacg ggtgattttt 1046761 ctttgaaaga tgtgacggga acaagcaagg tgccgaaagg aaaatatttt gtcgttggag 1046821 ataatcgcat atacagcttc gacagccggc attttggtcc gataagagaa aaaaatattg 1046881 tcggtgtgat ttctgatgcc gaataaaaag acgctaattg aagaggcgtc tttttgtatg 1046941 ccgtttggaa aaatgtgttg aagaaaaatt tgtaaggagc tataatcaaa attgttacct 1047001 gtgtaacaaa atttatatat ttttttgact ggagggccgt ttttattggt ttttgttcgt 1047061 ttttcatgaa acaaaaggag tggtgaatga tgatgaaata tgaagcagtg attataggag 1047121 gagggccggt tggatttatg ctggcttctg agcttgcaat agccggagtg ggaacatgtg 1047181 tgattgaacg gcttgaaaaa cctgttccgc attccaaggc gttgacgctg cacccccgaa 1047241 cgctggagct tcttgagatg agagggattt tagagcggtt cgtatccaag ggaagcaaga 1047301 tacctaccgg acatttttca atgctggata cccgtctgga tttttcaggc ttggatacga 1047361 gctgtcctta cacgcttttg ctcccgcagt ccaaaacaga aaagcttctt gaagatcatg 1047421 cacgaagcct gggaacagag gtgtttcggg gtgccgaggc gctggcggtt acgcaaaacg 1047481 gggaagcggt ccaaacaatt tttaaggatc gggacggcag tgtacggacg atcacaagca 1047541 agtttgccgt tggggcagat ggcgccggga gtaccgtccg gaaacaggcg aaaattgagt 1047601 ttccgggaac agacagcact gtcaccgctg cgcttgggga tgtggtgctc ctttctccgc 1047661 cgccgtcagg tgtgctgtcc ctttgcacaa aagagggcgg tgttatgatt gttccgttat 1047721 ctccagaccg ataccgtgtc gttgtgatca gcccttatcg cacacaaacg ccgaaagatg 1047781 tgcctgtgac tgaggaagag ctgaaagctg acctcctgcg aatttgcgga actgacttcg 1047841 gtttaaccga cccttcgtgg atgtcgcggt ttgggaacgc cgcgcgccaa gcgaaacggt 1047901 atcgggacgg cagaatcttt cttgcgggtg atgccgcgca tattcatttt ccggcgggcg 1047961 ggcaaggact gaatgtcggc cttcaggatg caatgaacct cgggtggaaa ctggcggcgg 1048021 ccatcaaagg ctctgcgcct tcttggcttt tggacagcta ccatgatgag cggcatccgg 1048081 cagcggaagg gctcctcaga aacacggagg cacagacaaa gctgatcgat ttcactcaag 1048141 caggcctcca tttgcgaagc atgatgtcgg agctgctggc cttccctgat gtgaatcgat 1048201 atgtagcggg gcaaatttct gcgctcgatg tcagatatga agctgatcgt accatgccgc 1048261 cgaatcgttt gaacggggca aggctccctg acatgaagct gattctttcc gacggcaatt 1048321 cggaacggct gtacagcttt ctccaaaacg ggacattcgt tttgctgtca ttgaggcagg 1048381 aagctgatga tcatatcgaa gtaaaaggct tacgtacggt aaccgcctcg cttgcagaac 1048441 cgaatgaaaa gttgcggaat gtgcatacca tattgattcg tcccgatgga catgtagcct 1048501 gggcggtgga tgcatcagcg cccgattgtt ccgaggtgat tcaaaaaggg atcagccgct 1048561 ggttttccgt caccagccga gtataattca attcgattgt ttcatctgta acaaaacggt 1048621 atgatagaag aaacaatcga atgaaaaagg atggaaaacc cgatgaacac agatcatacg 1048681 aaacgcaatc tttttgaatt gtatgcggag ctcattcatc agcaggagaa atgggagggg 1048741 cttattaaag cctttttatc tgacgaattg aggaagctgg atgtagagca cgggagtaaa 1048801 tctcaattga cgatgacaga aattcatgtt ctatcctgtg tcggggacaa tgaaccaatt 1048861 aatgtcacgt cgatagcaga aaaaatgaat acgacaaaag cgactgtatc acgcatcagc 1048921 acaaaattgc tcggcgcagg cttccttcac agaacacagc tcagcgataa taaaaaggag 1048981 gtctacttcc gattgacgcc tgctggaaaa aagctgcaca gtttgcacaa atattatcat 1049041 cagaaggctg aacagcgttt tctgtcattt tttgaccgct ataccgagga agagattctt 1049101 tttgcggaac ggctgtttcg ggatctggtg acaaaatggt atccgtcgtc agaagaaatt 1049161 gaaggggggc ttcctagcat ttttaaataa aaaacacgca ctgcggtgcg tgtttttcgc 1049221 tttgcggccg cctcgagaat tctttcattt caccctctgg cagcactcac ttcaaatctg 1049281 atccattaac aacgaaatat ccgcttatat ttcctcatct cgatggtttg cgaattaaaa 1049341 gttcttgaac ccttttttca actaggcact actgccgctg attgagctct ttttgtcttt 1049401 tttttcacca tgaagatggt gaagcaggcg ataaaacggc ggcagcaggg caataaccag 1049461 aatgacgcga atgacctgaa ccgcaacgac aaaggtggaa tcagcatgta aggtaactga 1049521 cgtcgtcgcc atctctgcaa tcccgccggg cgcaaatgcc agaacagaag tgatgagcga 1049581 aattcctgtc agctcggaaa cgatcacggc gctcaaaaac attgctgcga ttaaaccgac 1049641 ggacgagaca aacccgacga tgataatacg ggtgacgccg gcaaacatgc ttttgtacat 1049701 cttagagccg atcgttgccc cgagaaatac ttgtgataca tggttagctt gtgacaacca 1049761 ccatgccgtc atgtcgtgcc ctgtcaccgc agctccgcca acatgtacaa ttgctacacc 1049821 gagcatgctg ccgagcagcc atggagctgg aaattttaaa aatttcgcag ctttgcaagc 1049881 tccccaggca gcgagaataa gaatgacggt ccacaaaacg ggagcgagcc taaaatctgt 1049941 cgttgcagaa gaaatcgtct ctgctgcggc acttgcggta cgatcttgtt ttgtatagat 1050001 cagaatgact aaaaacggaa tggaaagcac cacgagcagc acacgcatca tttgaacgag 1050061 gctgactata gcggtattgg cgcctacttc ctgtgcgatg ctcggcatgg cggaaagtcc 1050121 gccgggagcg gtgccgacaa agctagtcat catatccgtt ttgctgaaac gccaaagcac 1050181 atatcctgac agcatggcca gcaggataga caatatcagc ataacgccga ctgaaaacca 1050241 atggtctttg agaacagaga gaacggataa attcagcttt tggcccaatt cgatgccgag 1050301 gatcatctgc ccgagggcga gccatcgtcg gttaattcct ttttggtctg gtgccatcat 1050361 cagccatgcc ggccgtatca tggcgaggca gcaggcgaca atcagtgttc cgatcatcca 1050421 tccaattgat attccggtta atgaaagaat aaaccccccg gctgcactga ttgcgataaa 1050481 ccatagatct ttgaggagat tttcgtcttt cttcaatgta aaacccttct tcctttttca 1050541 cgtaacactc caattgttca cgtagtgaat gtatttatta ctatagtata tttttgttga 1050601 taaagaaatt atgaattatt ttctataagc gattcacttt tcttatgacc ttgtgttcga 1050661 gcttttctat tgtgtaagtc agagataaac ccgctgtcag cagacacacg gcaagagcgt 1050721 aaaaaatcac ttctccgcca aatgatgtca ggatcagccc gcctgccagc ggtccgattg 1050781 agcgggatat atcccaatgc agaccataga cagcataaaa ccggcccagc aaatgaggcg 1050841 gcgccaattt cgatatgaag gtctggatgt gggttagccc gatgctttca ccaaccgtca 1050901 tcaccgctgc cgtcactaaa agcattgtca gagaggttga gcatgcaaag ccggctgccg 1050961 caagggagta gcaaatataa gtaatgaaga ggatcgtttt cattgaaagc ttttcggtcc 1051021 ctttgacaag aggtacttgg agaacacagc tgaataaagc ttttgctgct gaatagatgg 1051081 tcagcatgga cagataatca gaaaacatgt ttttgctgaa cagcctgtat gttgtttctg 1051141 tttgtgcata taacatgctg atggggagag aaagcagcaa aagaagcagg acaggcctgt 1051201 atattgtaaa gctcgcggac attttcgggg taacagctgg gtgtagcggc tttgtctcag 1051261 gcagtttcag tgcagcgatc agaaagtaga taaacaatgc tgcagcatct aatgcgaata 1051321 tccacacggg gttatgattg tacagcagca tccccactag cggtcctgcc gtcagacccg 1051381 tcgaatagat cgcattgatg accgcaaaca cttccgaacg tctgctttcc ggcgtgcttt 1051441 cagcgatttg ggcgcgggaa gcgggaatgt acaacgatct tccgatgcca ttcatgacat 1051501 agagaatagc gaaaacatac gcatgctcag caaatacaaa ccctgtcatt gccgctgatt 1051561 gaagaagcaa tgcggtcaaa atcgctgtgc gccgcccaag ccgatccgtc acccgtcctg 1051621 cagcgagcgt caggaaaata tcagcaaatg gctgaaggct gatgatcagc attggcatca 1051681 tgatactgcc gtttaattgt tcatgcagat acagcaccat aaaaggtccc atcattgcac 1051741 ctgtcaggct tgtcagcaat tcgccgaaaa agcggagccg aacgggagcg gtatatctcg 1051801 attttataga gtgaaaactg gtcaacatgt gatcgccgcc tttcgctgtt tgatatagta 1051861 gtagtgtata gaaggggcgg cggcccaaaa agtgaagaaa agaagagata aaagttcccc 1051921 ttttgtcggg aggtgcgggg attgaagctg atagagcact acgtggcgct tgtaaaaaca 1051981 ggctgcgccg agtatgggca aatgaacgaa atgacgctca ctgagattgc cgactgttta 1052041 ttttgtacag aaagaaatgc aaagctcatt ttacataagc tggagaacag caattggatt 1052101 atccgggaaa gcggggcggg gcgcggccgc aaatctaaaa tcgcgtttct tcggaggcct 1052161 gaggaactgc ttcttcaaac tgcaaaggaa tataccatgt caggaaagct taaaaaggca 1052221 aaggagctgc ttcagcagta tcagtccgcg tttccagggc ttcaaaacga atataacatg 1052281 tggctatcag aggtattcgg atttgtgacg gagacaggcg agaatggggc gaaggatgtc 1052341 ctgcggctgt tcatcacgcc tgaatctgtc agcagtttgg atccatgcca aatatttttg 1052401 cggtctgagg gccatttcgt caaacagata tttgatacac tcttcacgtt tgattcggat 1052461 atgcaggagc cgaagcctca tttggttcat ggatgggaag aggtcggaaa aaaacaatgg 1052521 agattttttc ttcgaaaagg tgtgttattt cataatggac agccgctgac atcgcgggac 1052581 gttgcgttta catttcagcg ctttttggaa ctggctgaca acccgtataa atggcttctg 1052641 cacggagtga aacaagtctt agaaaagggc ccttattgtg tggagctcat actcgataag 1052701 ccgaatgcgc ttttgccgta tgctctttgt gatgaacggc tgtccatact gccggcagaa 1052761 cagggcggcg ggaaaaatgg aacagggcct tttcagatga atcagcaaca tagcgggatg 1052821 cttgtgcttg aagccaatga gcgctacttc aagggacgcc cctatttgga tcgcgttgag 1052881 tttgtgtttt ctgagcaagc cggagagatg aacggtttta ccattcaaga aaaacaaaca 1052941 tgtcctgagc agcaaactgt ctttgatgag cggcatgttc agtatttgtc gcttaatctg 1053001 aaaaagaagg ggcctcttca gcaccgaagc tttagaaaag cgctccggct gctgatttcc 1053061 tctgaacggc tcgttcgtga agcgggaggg caccgaagaa ttccggttac gtcctttttg 1053121 catccgagtc cttttgagtg ggagggcgtt tcgccatctg aattgttgaa aaaaagcgga 1053181 tacgagggcg aaacaatcgt gctttatacc ttttcggaaa cggatcatcg tgaggacgcc 1053241 gaatggattc aaaatatttg cgcccagcac ggtatcaggc ttacacttca attctgtgat 1053301 gctgctgatc tgcgacggcc ggaaatcgtg cagatggcgg atatcattca tgacagtgcg 1053361 acgttttatc aagacagcga gtttggtttt ctgcatttgc tgctgtcgga gaacagtttc 1053421 ttgtatcagc atctatctga aaagctgaca cagatttgct caggaatgac agagcggatg 1053481 ttttccatgc ctgaccgctg ttcgagaatc aacatcctgc gtgacattga ccggcagatg 1053541 atacaggagc tgaacgcgat cccgctgtat caaaatgtgc tccaggtgac atcaagtaaa 1053601 aatgtaaaag gcctggtgct tgatgaagag ggatggattg atttgtactc cgtatggctg 1053661 tccaaataaa aagagggttc ttttttgaac cctctttttt acgctgccat gctgcggcat 1053721 tgttcagcac aggtgaagca ggctttcgca catgcttggc aatgatcatg atcgtgcttt 1053781 ccgcattcag tgccgcatgc ttcacaaata tcggcgcaaa gtgcacaaat ttctttcata 1053841 aacgggctgt ccgtttgcat ggctttgacc gccagcgcgc aaatatccgc gcattccctg 1053901 tcaagccgga tgcatccgct gagatgatgc tgcacgcttt cttccaagca tttagtgaaa 1053961 caatgattgc aagccttcat gcaatcgatg caagcctcaa tacaagcctc agaatattgc 1054021 tccatggttg attccccctg tatgacagta tatggtttta tgtttcacgg ctgcatttga 1054081 aaaaaacagg ggagtgtgtt tttagctaag gggatatgta catataccct gaatgggtat 1054141 atctaacgtt ccatcagata gtataggaac cagacagcgt gattttgttc atcacgtgct 1054201 gcgcgcgtaa agacgccttt cgcttttaag tttgacgttt cctcggccgc acgcaagtaa 1054261 aagtcgacgg tttcttgttc atctttaaaa gcggcgtcca gtcctcttgt gaaattgtcc 1054321 gggcattctt ccgtttgttt cggcatgatg tgtttgccgg taattgaacc atacagtgtg 1054381 gaaaattcac ggaggtggcg aatctcgtca cgcctgattt cttcaatctg ttttctgacc 1054441 tcatcgctgt gggcgagttc ggcaagcttg cggtagcatt gaatagcact gaattctccg 1054501 ttgatggcct tctgcaaatt ccgaatcaaa acaggatctt cccggtatgg caccggatag 1054561 ggatagtagc tgtaatgcaa ggggattcaa ctccattctt aggaattggg cttctgtaaa 1054621 agtatatgtt gggcagggag agatgtgcgg agataatcag ctttttatat gtgaaaaggc 1054681 cgtttttacc aatagatcag attggtcatt ttcgtcaaca ttcgataaaa tatagagaga 1054741 taaaaagaga ggggtcttct aatttgggag cagagttttt agtaggcagg tccgggagtg 1054801 gaaaaacgaa gctgatcatc aacagcattc aggatgaatt gcgccgggct ccattcggga 1054861 agccgatcat ttttctagtc ccggatcaaa tgacgttttt aatggaatac gagcttgcta 1054921 aaacgccaga tatgggcggg atgatacgcg ctcaagtgtt cagtttttca cgattggcct 1054981 ggcgcgtcct ccagcatacg ggaggaatga gcaggccgtt tctgacgagc accggcgtac 1055041 aaatgctcct gcggaagctc attgaggagc ataaacagga gttcaaagtc tatcaaaaag 1055101 cgagtgacaa aagcgggttt accgcacagg ttgagcggat gctgacagag tttaagcgct 1055161 attgtctgga accggaggat atccgccgga tggcggaaag cggaacggct tccgagtatc 1055221 gcggagaacg tgttttatct gaaaagctcc atgacttatc aattctgtat cagcaaatgg 1055281 aaaaaagcct cgcagatcaa tatcttcact ctgaggatta tttgacattg ctggcagagc 1055341 atatcccgct tgcggaagat ataaaaggcg cccatatcta tgtggatggc ttttatcagt 1055401 ttaccccgca ggaattcagg gtgttggagc agcttatggt tcatgcggag catatcacgt 1055461 tttcgctcac agcggacaag ccgtcatatg agcgggagcc gcatgaactg gaattgttca 1055521 gaatgacggg gaaaacctat taccgcctgc atcagaaggc gaaggaactg aatttggaca 1055581 ttacgtataa agagctgagc gggactgagc ggcatacaaa gacgccggaa ttggcgcatc 1055641 tagaggcaca gtatgaagcg cgtccggcca ttccatacgc agaaaaacaa gaagccctta 1055701 ctgtgatgca ggccgcaaac agacgagctg agctggaagg cattgctcgg gaaattcacg 1055761 ccctagtcag agagaaggga tatcgctata aggatgtagc aattcttgcg cgccagccgg 1055821 aagactacaa ggatatggtg aaggaagttt tcgcagatta cgagattcct tatttcattg 1055881 acggaaaagc atctatgctg aaccatccgt taattgaatt tatccggtcg agccttgatg 1055941 ttctgaaagg gaattggcgt tatgaagcgg tgtttcgctg cgtgaaaacc gaactgctat 1056001 tcccgctcaa tgaaccgaag gccaaagtga gagaacaggt cgatcagctc gaaaattact 1056061 gtatcgccta tggtattaaa ggcgaccgct ggacaaaggg cgatcggttc caatacaggc 1056121 gttttgtgtc attggatgat gattttgcgc agactgatca ggaaatcgaa atggaaaaca 1056181 tgttgaatga cacccgcgat tggattgttc cgccgctttt tcagcttcaa aaacgcatga 1056241 aaaaagcgaa gacggttcaa gagaaggcgg aggcgctcta tcgttattta gaagagacgg 1056301 atgtgccgct gaagctggat caggaaaggc agcgtgctga ggatgacggc agaatcattg 1056361 aagcgcagca gcatcagcag gcgtgggacg cagtcattca gctgcttgag gagtttgttg 1056421 aaatgatggg agatgatgag atttctcttg atttgtttca gcaaatgata gaagccggcg 1056481 cggagtcgct tacattttct ctaattccgc ctgcgcttga ccaggtgttt gtcggcaata 1056541 tggatttgtc cagaatgtat ggcacctcct gcacctttgt gctcggggca aacgacggcg 1056601 ttctgccggc acgccctgat gaaaacgggg tcctgtcgga tgatgaccgg gaatggctga 1056661 aaacgattgg ggttgagcta tcctcaggcg gacgagagcg tttgcttgat gagcacttcc 1056721 tcatctacat ggcgttttca agtccgtctg accggcttta cgtatcgtat ccgattgctg 1056781 atgcggaagg aaaaacgctt ttgccgtcga tgatcgttaa gcggctggaa gaactgtttc 1056841 cgcatcataa ggagcgcctg ttaacaaatg aacctgaaca ggtcagcgat gaggaacagc 1056901 tgatgtatgt tgtgaataaa agcgtggcac agtcctttac cgcgagccag ctcaggttat 1056961 ggactcggga atacgacatc agcgacgtct ggtggagcac gtacaatgtg ctgatgagtg 1057021 agcaggacag gctgcaatcg aaaaagctgt tctcaagcct gtttttccgg aatgaagtga 1057081 agcagcttga acgcagcgtg tcgagacagc tctatggtga acgtattcag ggcagtgtat 1057141 cgagaatgga aacctttaac gcatgcccgt tttcccattt tgcgtcacac gggctgcatt 1057201 tgaaggaacg gcaattcttc aagcttgaag caccggatat cggccagctg tttcattcca 1057261 gcttaaagct gatttcggac aggctgcgtg agcaaaagct ggattggcgc gatttaacga 1057321 aggagcagtg cgagctgttt tcctatgatg cggtagagcg gctggcaccg aaactgcaaa 1057381 aggaaattct gctcagctca aaccggcatt attatgtgaa ggaaaaactg caaaaaattg 1057441 tgacacgtgt gtccggcatt ttaagcgagc atgcgaaagc gagcggattc gtaccgatcg 1057501 ggcttgaact gggctttgga ggaaaagggc cgcttccgcc gctgaccttt caactgaaaa 1057561 acggctgtac gatggaactc gtcgggcgaa ttgaccgtgt tgataaggct gaaagctcaa 1057621 aaggcctgct cctcaggatt gtcgattata aatcaagcga caaaggcctt gacttagcgg 1057681 aagtatatta cggattggca ctgcaaatgc tgacgtacct tgatttatcg attacacatt 1057741 cagctgactg gctcgggatg agggcgacgc ctgccggagt gctgtatttc catattcatg 1057801 acccgatgat tcaatctaat ctcccgcttg ggcttgacga gattgaacag gagatcttta 1057861 agaaatttaa aatgaagggc ttgctcctcg gtgatcagga agtggttcgc ctcatggata 1057921 caacccttca agagggacgt tcaaatatca taaacgccgg cttgaaaaaa gacggctctc 1057981 tcagatcaga ctcagcagca gtcggtgaaa aggaatttga tcttttgaca aagcatgtgc 1058041 gccgcacctt ccaagaagcg ggcgaacaaa tcaccgacgg gcgcgtatcc attgagccgt 1058101 acaaaatgaa gaacaagacg ccgtgcacat actgtgcgtt caaatcagta tgccaatttg 1058161 atgaatcact ggaagaaaac gagtatcgcc cattaaaggc tgaaaaggac aagacaatac 1058221 ttgagtggat aaaaaaggag gcggatggca atgaacattc ctaaaccggc agacagcaca 1058281 tggacagatg accaatggaa tgccattgtt tcaaccggcc aggatattct tgtggcagcg 1058341 gctgcgggct ctggtaaaac cgctgtgctc gttgaacgaa tgattcggaa aatcaccgcg 1058401 gaggaaaacc caatagatgt agaccgtctt ctcgttgtga catttacaaa cgcctcagcg 1058461 gcagagatga agcaccgaat cgcagaagcc ttggaaaaag agcttgtaca gcgccccggc 1058521 tcgctgcata ttagacgcca gctgtctctt ttaaaccggg ccagcatttc gacgctccat 1058581 tccttttgcc tgcaagtgct gaagaaatat tactacttga tcgatcttga tccgggcttt 1058641 cggatagctg atcagacgga aggcgagctg atcggggatg aagtgcttga cgagctgttt 1058701 gaagacgaat acgcaaaggg cgaaaaggcg ttttttgagc ttgttgaccg ctatacgaca 1058761 gaccggcatg atctggatct gcaatttctc gttaaacagg tgtacgagta ttcccgatcc 1058821 catcccaacc cggaggcgtg gctggaaagc tttgttcatt tgtatgatgt atcagaaaag 1058881 agcgccatcg aggagctgcc gttttatcaa tatgtcaaag aagatattgc aatggtgctt 1058941 aacggggcga aggaaaagct cttgcgcgcg cttgagctga cgaaagcgcc gggcggcccg 1059001 gcgccgcgtg ctgacaattt tcttgatgat cttgctcaga ttgatgaact gattcagcat 1059061 caggacgatt tcagtgaact atataagcgg gtgcccgccg tctcttttaa gcgtgccaaa 1059121 gcagtaaaag gggatgagtt cgatccagcg ctccttgatg aggcgacaga tttgaggaac 1059181 ggcgcaaaaa aactgcttga aaagctcaaa accgactact tcacgcgaag tcctgaacag 1059241 cacttgaaaa gcctagccga gatgaagcct gtcattgaaa cgctcgtaca gcttgtcatc 1059301 agctatggaa aacgattcga agctgcgaaa caggaaaaat caatcatcga tttttcggat 1059361 ttggagcatt actgtttagc gattttgaca gctgagaatg acaaaggtga acgtgagccg 1059421 agcgaggctg caaggtttta tcaggaacag tttcatgagg tgctcgttga cgaatatcag 1059481 gataccaacc tcgtgcagga atcgattctg cagctcgtca caagcggtcc ggaggagact 1059541 ggtaacctgt ttatggtagg agatgtcaaa cagtcgattt atcgattcag gcttgcggag 1059601 ccgcttcttt tcctctctaa atacaaacgg tttacagaga gcggagaagg cacggggcgg 1059661 aaaatcgatt taaataaaaa tttccgaagc cgggctgata ttttagacag cacaaacttt 1059721 ttatttaaac agctgatggg cggcaaaatc ggtgaggtcg attatgacga gcaggctgag 1059781 ctgaagcttg gtgcagcgta tccggacaat gacgagacgg aaacagagct gctgctgatc 1059841 gacaacgcag aagatacgga tgcaagcgag gaagcagaag agcttgaaac ggtgcagttt 1059901 gaggcaaaag ccatcgctaa ggaaattcgt aagctgattt catcgccgtt taaggtgtat 1059961 gacggaaaaa agaaaacaca tcgcaatatt caataccgag atatcgtgat tttgctccgt 1060021 tcgatgccgt gggctccgca aatcatggag gagctgagag cacagggcat accggtttac 1060081 gccaatttaa cgtcaggcta ttttgaagcg gtcgaagtcg ccgtcgcgct ttctgtgctg 1060141 aaggtgattg ataatccgta tcaggatata ccgcttgcct ctgtgctgcg ctcaccgatt 1060201 gtcggagcag atgaaaacga gctgtctttg atccggcttg aaaataaaaa agcgccgtac 1060261 tatgaggcga tgaaagacta cctggctgct ggtgaccgga gcgatgagct ttatcaaaag 1060321 ttaaatacgt tttacggaca tctgcaaaaa tggcgcgcgt tttcgaaaaa ccactcagta 1060381 tctgagctga tttgggaagt gtaccgcgac accaaatata tggattatgt cggcggcatg 1060441 ccgggcggaa aacagcgcca ggccaatttg cgtgttcttt atgacagggc gcgtcaatat 1060501 gaatcaacgg catttcgcgg cttgttccgt ttcctgcggt ttatcgaacg catgcaggag 1060561 cggggcgatg atcttggtac ggcgagagcg ctcagcgagc aggaggatgt tgtccgctta 1060621 atgacgatcc acagcagcaa agggctcgaa tttccagtcg tgtttgtagc aggtctcggc 1060681 cggaatttca acatgatgga tttgaacaaa tcgtacctgc tggataagga gctcggattt 1060741 ggcacgaagt atattcatcc gcaattacgc atcagctatc cgacacttcc gctcattgcg 1060801 atgaagaaaa aaatgcgcag ggagctgctg tcagaggaat tgcgtgtgct ctatgttgca 1060861 ttaacgagag cgaaggaaaa gctgtttctg attggctcat gtaaggatca tcagaaacag 1060921 cttgcaaaat ggcaggcatc cgcgtcccaa actgattggc ttctgccgga atttgaccgc 1060981 tatcaggcga gaacgtatct agatttcatt gggccggctc ttgccaggca cagagacttg 1061041 ggggatttgg ctggtgtgcc agcacacgct gacatctcag gtcacccggc tcgttttgcc 1061101 gttcaaatga tccattccta tgatttgctt gatgatgatc tggaagaaag aatggaagaa 1061161 aaaagcgagc gcctagaagc gatccgccga ggtgaaccag ttcccggctc gtttgcgttt 1061221 gatgaaaaag cccgcgagca gctgagctgg acctacccgc atcaagaagt gacgcaaatt 1061281 cggacaaagc aatcagtttc tgagatcaag agaaaaagag agtacgagga tgaatacagc 1061341 ggcagggccc ctgtaaaacc ggctgatgga agcattctgt acagacgtcc cgcttttatg 1061401 atgaaaaaag gcctgacagc ggcagagaaa gggactgcca tgcatacggt tatgcagcat 1061461 atcccgctgt cacatgtgcc gtcgatagaa gaagctgagc agacggttca caggctttat 1061521 gaaaaagagc ttctcactga agaacaaaaa gacgctattg atatagaaga aatcgtgcaa 1061581 tttttccata cagaaatcgg cggacagctg atcggtgcta agtggaagga ccgggaaata 1061641 ccattcagct tagcgcttcc ggccaaggag atctatcctg atgcacacga ggcagatgag 1061701 ccgcttttag tgcagggtat tattgactgt ctctatgaaa ctgaggacgg attatatcta 1061761 ttggattata agtcggaccg gattgagggc aaattccagc atggatttga aggagcggcc 1061821 ccgatcttga agaaacgata tgaaacgcaa attcagctgt acacgaaggc agtggagcaa 1061881 attgcaaaaa caaaggtaaa gggatgtgcg ctttatttct ttgacggagg gcacattctg 1061941 acattatagc gagatccata agctccggaa tttcaggcgg agcgggtctc gttttctata 1062001 taaaagagag gtgaaagcat ttgcggattt tacatacggc tgactggcat cttggaaaaa 1062061 cgcttgaagg aagaagcagg ctgagtgaac aggccgatgt gctggatgaa ctgaatacga 1062121 ttgtaaagga tgagcagatc gatgccattg taatggcggg ggatgcattt gacaccgtaa 1062181 acccgccagc tttagccgag cagctgtttt atgaaagcct gtctgcgctt agcgacagag 1062241 gaaagcgccc gatcgtcgtc attgccggaa atcacgataa tcctgaccgt ttgtccgccg 1062301 cttcaccgct gacacatgaa aacggcattc atttaatcgg ttatccgaca acagagccga 1062361 ttcatattga agtgccttca gcaggagagc ttttggcggt tggagcgctg gcgtacccat 1062421 ctgaagcgcg gttaaatgaa gtgctatccg atacgtttga tgaaaagctg ctccgtgatc 1062481 actatgatgt gaaaatcagg caggcgtttg agcatatgac aagccggttc cggaccgatg 1062541 cagtgaagat tgccgccagc catatttatg tggcaggcgg aaaccaaacc gattcagagc 1062601 ggccgattga agtcggcggt gcatacacgg tggctgctga aagcctgccg gcagatgccg 1062661 cttacgttgc gctcggccat ttgcatcgcc cgcaaacgat caagcgggcg cggacgcttg 1062721 cgcgttattc aggatctccg ctcgcctaca gcttttctga agcgggctac gctaaatcag 1062781 tgacgattgt ggacgcaaag cctggggaag aggccacttg gcaagaggtg ttattatcaa 1062841 gcggcaagcc acttgtgaag tggaaagcgg caaatggatt aagtgaggtg tacagctggc 1062901 tggatgaagg cagagatcag aatgcttgga ttgacttgga aatccgtgtc gcggaccagc 1062961 tgtcacttga agagattcac aggctgcgga aggcgcaccc gggctttatc catatcaggc 1063021 cggtttttga agaacagaac aaagaccggg aacggatcga ggttaaacat gtctcaatcg 1063081 aggaccgctt taagaaattt tatgaaaaac aaactggcgg tgcggtgccg gatgaagaaa 1063141 tggtgaagct gtttttagag cttgcatcag gcgttgaaga ggaggatgcg aaatgaagcc 1063201 gatcgcctta agcattaagg ggctccacag ctttagagag gagcagacga tagattttga 1063261 aggcctttcc ggtgccggtg ttttcggcat tttcggcccg acaggaagcg gtaaatcctc 1063321 tatactcgac gcaatgacgc ttgctttata cggaaaggtg gaacgggcgg cgaataatac 1063381 gcacggaatc ttaaatcacg ccgaagatac gctgtctgtg tcctttacct ttgcgcttca 1063441 gacgaatcac caaatctcat acaaagtcga gcgtgtgttt aagagaacgg atgaaatgaa 1063501 ggtaaaaacg gcactttgcc gcttcatcga aatcaaggac gagcatacgg tgctggctga 1063561 taaagccagc gaagtgaata aaagagtgga ggagctctta gggctgacga tcgacgattt 1063621 tacgagagcg gtggtgctgc cccaagggaa atttgctgaa tttctgtctt taaaaggggc 1063681 agagcgcagg catatgcttc agcgtttatt taatttggag caatatggag acaggcttgt 1063741 gaaaaagctg agacggcagg cgcaggaagc caatgcgaga aaaaatgaaa tgcttgctga 1063801 acagtccggt ctcggtgagg cgagctcaga ggcagtggag caggctgaaa aggttctcga 1063861 acaagctgaa gcccggctgg aagcgatgag gaagaaccgt gatcaggcga aggagcggtt 1063921 tacagagcat caggagatat ggaatgtcca aaaggaaaaa tccacttatg aagaagagga 1063981 aaaacgtctc gcagaagaac agccgcatat agacagcatg caaaaacgcc tgctggaagc 1064041 agaaacagca gcagccctta agccctatgc ggaccggtac gcagaagcga tccagcatga 1064101 ggagcaagct gaaaaggaac aaacgctagc ccaaaaggat ttagcagacc ggacagcttt 1064161 ctttcagcaa aaacatgaag agtatgaagc gtggcgccag cataaaagcg agaaagagcc 1064221 tgagctttta gccaaacagg aacagctttc acgcttgcag gaaatcgaaa tcaaactgag 1064281 tgaggccaag caagaggaag agcgcaaaaa ggctgacctc cggcagaaag aagaggctct 1064341 tcaatctgtc atgaatgaat tagagaccgt aacagaccgc ctgacacgag ggcaaaacag 1064401 acagacagaa ttgaagcagc agctcaaatc cctgcaggtg acatccgatg agcgaaaaag 1064461 ctgccagcag gccgcagaga tggcattgcg catcagacaa accgaggaac aaatcaaaaa 1064521 agagaaaaaa cgaagtgaag aattgaacct cgtgctgcag aagatgaatg aagagaagaa 1064581 tacactcgtt caaaagacgg aagcggaaga aaacaacatc attcaggcat atgaggcagt 1064641 tcaaactgtg taccatttgg tgtgcgaaac ggaacgctca ttaacacgta tgacggaaga 1064701 ggctagaaag agtcaacaca cgcttcactt acagcgtgaa aaagcaaggg tggcactgct 1064761 gacaaaagag ttagcccaaa agctgactgc cggaaagcct tgcccggtat gcggttcaac 1064821 cgatcatgat ccatctgcct cggtacatga aacgtatgaa gccgacagcc atcttgaaga 1064881 ggacatcaaa cggacagatg tgttattgac ggaagctgca gctctcagcc aggagattct 1064941 ttcagccaaa attatgcttg aagaacagtc cgcgcgcttt attgaacagt gtccgttttt 1065001 gcagacaatt caagcacaga accttgaagc ggcagcttcc ttcgaacatc agccggtgta 1065061 tgaagcattt gaaactgcca aatttgaatg gaaacgaatc aagcaggaca ttctttctgt 1065121 taagacacga atggcacaaa tgattggcgc ctatcaggag tctttaaaaa aggccgagca 1065181 gcttaatgaa aaaatcggtt ttgaaaaaag agaagccgac cgtattgaaa gcatcatcag 1065241 tgagcttcaa tcctcaatgg acagcagtct gaacatgttt aaagaagcat ttcagaatca 1065301 atctgtggac gaagcagaaa aatggcagca agccattgaa gaaaaggacc gggctgcaga 1065361 agaatgtgaa aaacgaattg agaagagtat cgcgtttctt gctgagcatg aagcacaaaa 1065421 ggaaaaactg cgggaatcgg gacaccggct tgagcgggaa aagctggagc ttcattatgc 1065481 ggctgaacgc atcaagagcg tgatagctga ttatgagcac gaactcggag attatgcaaa 1065541 aggagattcg attcaaatca aactccgctc tgtccagcag gatctaaagc tgttaaagga 1065601 aaaagaacaa tctttatatg aagaactgca aagcgcccaa atgaagctca accaagcgaa 1065661 aagccgcgct tctgcaagcg agctcactct tcaagaggcg aagggcagat tggaaaaagc 1065721 aaaagctgct tggcttgagc atacaaaaaa cacctccatt acccggactg aggaggttga 1065781 acaaagtctc atcccagctg atgaacttga aaagatgaaa accggcatag accagtttat 1065841 ggataaactg aagcaaaatg ctgcaaactt aaaacgagta gcagagatac ttgccggcag 1065901 agcattatca gagagcgaat ggaacgaaac cgttgcagca ttacaagaag ctgaggacgc 1065961 atttggcgct gctatagagg aaaaaggcgc ggccgcaaaa gcactggctg tcattcgcga 1066021 ccatcataaa cggtttaatg aaattgaagc tgaactgaaa aaatggcaga tgcatatcga 1066081 caggctggac aagctgcaag ctgtgtttaa aggcaatacc ttcgtcgaat ttttagctga 1066141 ggagcagctt gaaagcgttg cgagggacgc ctcagcaaga ctcagtatgc tgacaagaca 1066201 gcgctatgcc atcgaagtag attctgaggg cggcttcgtg atgcgggatg acgcgaatgg 1066261 aggcgtacga cgcccggttt ccagtttgtc tggaggagag accttcctca cctcgctttc 1066321 acttgctctt gcgctgtctg cgcagattca gcttcggggg gaatacccgc tgcagttctt 1066381 tttcttagat gaaggcttcg gcacactgga tcaagatctg cttgatacgg ttgtaacggc 1066441 cttggaaaaa cttcagtcag acaacctggc tgtcggtgtc atcagccatg tgcaggaact 1066501 gcgtgcacgg cttccgaaaa agctgatcgt ccatccggct gaaccgagcg gccgcggtac 1066561 gcgggtatca cttgagttga tgtaagggag gagcggatat ggcaaagcag attgccggaa 1066621 tatgtgagct gtgcggccgg agcgatgtcc agctgacaga gcatcatctt acaccgaaag 1066681 aggaaggcgg aacgtttttg ccgacagcga tgctctgtat tccttgtcat aaacagattc 1066741 atgccttata taccaatcaa gagctcgctg tacgtttaaa tggaatggct gaactcagaa 1066801 gcgatccaga gcttgcccgg tttgtcaaat ggatcagaaa acagccgcct gagaagctga 1066861 tcaaaactaa gaaatcaaat gaacgaaaaa agaaaaaatg actaaaaagc agccctctct 1066921 ttgcagagcg gctgctttta tccgtttcca accatatccg gaagcaaaag ttgttgttga 1066981 aaagtaacca aaaagcggtg ctcgatgcac cgctttttta tttgcgcccc cgttggactg 1067041 ctgtgtacat aatggatcgc tttccgtttg aagccgtcca ttcaaaacgg tctcctgtcc 1067101 cttcgctgct gtagttgtag tgatgctgca tcgcgcattg tgcggtgtca tttgaaaagt 1067161 gataaaagga cacaccctgc cccgccgaag tattcgaaaa gactccttta ttataagaaa 1067221 agacgcaatc gaataccgat aagccgaagc tgtgcaagtg ctgcagaaat gcgagaaagg 1067281 tttcgtcgtc aagcgaatcc aaaagcgcca tgagcggccg cttgactgat ttctcatagc 1067341 ggatgcgttc tccgccggaa agggagatgt tttctgcacc gcatgccaaa accaacttgt 1067401 cctgaaagcc ggcttgctcc cactttcctt tatgatggat ccagattggg ctgtgttgga 1067461 gactgtccgc cagcagtata tcgccttcac cgttttcgat taagcagatg ccgtcttcaa 1067521 tgaggatggt gccgtattcc cactttcgtt cctctgtata taacaattgt ttccgtttca 1067581 tccatgctgt ctcctttttc ttcattcctc tcttttcttt ccaattcaag cctgtcccat 1067641 acaactcttt tatggacaaa tcaactatct gcctatagat gcataaactt actaaggtgc 1067701 tgaaagaaac gaaattgtta cgaaagaaac gggattggag ctgatgtcac atgtgtggaa 1067761 ttacgggttg ggtcgatttt aaaaagcagc tcgtccagga aaaacaaacg atggacagaa 1067821 tgacagacac tctttccaaa cgagggcctg atgattcaaa cgtttggggg gagcaccatg 1067881 ttttattcgg acataaaaga cttgcggttg ttgatattga aggcggacgc cagccgatgg 1067941 cgtgtaccta taaaggcgat acgtacacca ttatttacaa tggcgagctt tataacacgg 1068001 aagatttgcg caaagaattg cgggcgcggg gccatcaatt cgagcgtacg tcagataccg 1068061 aggtgcttct gcacagctac atcgagtggc aggaagactg tgtcgaccat ctcaatggca 1068121 tattcgcttt cgctgtgtgg gatgaaaagc gtaatctgtt gtttgccgcg agagaccgtc 1068181 tcggtgtaaa gccgtttttt tacacgaagg aaggctcttc atttctcttc gggtcggaaa 1068241 tcaaagcaat cctcgcgcac cctgatataa aagcgcgagt ggacagaacg ggactttctg 1068301 aaattttcgg tcttggaccg tccagaaccc cgggcactgg catatttaaa ggcataaaag 1068361 aaatccgccc ggctcacgcg ctgacatttt ccaaagacgg acttaatatt tggcgttatt 1068421 ggaatgttga aagcgaaaaa catacggaca gttttgatga cacggttgcc aatgtcagat 1068481 cgttatttca ggacgcggtg acgcggcagc ttgtgtcgga tgtgcctgtt tgcacattcc 1068541 tatcaggcgg tctggactca agcgcgatta cagcgattgc ggcgggccat tttgaaaagg 1068601 aaggaaaagc accgcttcat acttattcga ttgattacga agagaacgat aaatattttc 1068661 aagcaagcgc ttttcagccg aatgatgacg gaccatggat tgaaaaaatg acagaggctt 1068721 tcggcacaac gcaccacaaa tgcgtcatca gccaaaaaga cctcgttgat catttggagg 1068781 aagctgtact ggtcaaagac ttgccgggaa tggcagatgt cgactcatcc ctgctgtggt 1068841 tttgccggga aatcaaaaag gactttgtcg tcagcctatc gggagaatgc gcggatgaga 1068901 ttttcggcgg gtacccgtgg ttccatacgg cagatgttga gtctggcttt ccatggatga 1068961 gatcaacgga ggagcggatc aagctgcttt ctgactcatg gcagaaaaaa ttgaatctga 1069021 aagaatacgt aaatgccaaa tatgaagaaa ccttggcaga aacgccatta ttagacggag 1069081 aaacgggtgt ggataaagca agaagacagc tgttctattt aaatatgctt tggtttatga 1069141 cgaacctttt ggatcggaag gatcgcatga gcatgggggc gagcctggaa gtgcgggtgc 1069201 cgttcgccga tcaccggctt gtggaatatg tttggaatat tccgtgggaa atgaaaatgc 1069261 atgataatcg ggaaaaaggc attttgcgca aagcgcttga gggcattttg cctgatgaca 1069321 ttttgtatcg caaaaaaagc ccatatccga aaacacatca tccggaatat acaaaaggcg 1069381 tcagcgagtg gctgaaaacg atcagaagcc aaaaggactc cgtgctccat accttactgg 1069441 acagaaaaca attagatcag cttttagaaa cggaaggctc ctccttcaag gtcccgtggt 1069501 tcgggcagct catgaagggg cctcagctga tcgcccatct tgctcaaatt catacatggt 1069561 ttgaagcgta tcgcattgat attgacgaga ggtaggttca atacaaatgt gattaaaagc 1069621 cagagatgta tagatttaaa taagaaggat agatgagcag ggaaatatat gctctatcta 1069681 tccttttttg tacaacagca ctatcgaatt gcccccgcat tccttcaata agaatgaata 1069741 ggttttaatg ttctgccgat aaaactagct gataccgggc ttaactttaa ttccctagcc 1069801 catacagaaa gttgaccaat atggtgaatt tcgtgagcga tgatatggtg taatatttca 1069861 tctcgcgtat ataaaacacc tgtctcccaa ggaacgctta caagttcatc ttttatttga 1069921 tctgaatgtg tttgtaaaac atcaattatt tcagttcgga atgtatttga gagagatttc 1069981 actttattga gtgtttgata atcagcgaac tgaacagcga tatcttcttt tccttggata 1070041 gcacgaatcc aactatattc cacatcaata atatgaaaaa gggtatataa aatattctct 1070101 actccgccaa gacgattttt aagtaattct tcagtggtta gttgatgaca ccaagtaaac 1070161 cattgatctc taacctgcca gttatattca aaaaatttca tcactaaact cactccaata 1070221 ctatcatgta tcataacaat tagccctttt ttccgtgatt cctctattaa tgaagtgatg 1070281 attgagaaat gtttacattc tacctgttgt atggcattaa aaataataat gcatatctcg 1070341 tcgatgatgc tgtgcgtctt gttactttta caaagtaaga atcggcattt tcttcatata 1070401 caattaggaa aaaacatact agacttgaag aagcagtgat acataggagt gagaaaatga 1070461 aagagataaa agaagcttac cagcaatgcg gacagattgt tggcgaatac gcgccagcct 1070521 gtttcaaagc attatcatat ctcccgctaa agcaaagaca agcctcttgg gcagtattgt 1070581 cgttttgcca cacggcggcc agtgcagacg aaaaggtatt gcccgcattt gaagctaaag 1070641 ctgatcatgt ttaccaaagg acaaataacg gtaaacaaca tctatggaag gcttttgatc 1070701 atgcgtatcg gacctttaca ttggaaagcg aaccttttcg ggagtttatt gccgcacaaa 1070761 aagaagacgc caagccgtat gatgaccttg atgaactgct catgtacgca tatcggacgg 1070821 gcggtgctgc cggattgatg ctgctgccga tactgacacg ccgaaaacaa gatcagctca 1070881 aacaagcagc cgtctctctc ggcttggcca tacagctggt tcgcttctta agtgatcttg 1070941 gcacagatca gcaaaaaaac cgcattcccc gtcaggtaat gcagcaattc ggctatacag 1071001 aggctgatct ccaaaaaggc accgtaaata aagcgttcac aatgacgtgg gagtatatcg 1071061 cttttgaagc agaagcctac cttgaagagt gtcaggatgc cttgccgcta tttccgcagt 1071121 attctcaaaa aacggtgaaa gccgctcttc atttgcaccg ggctgtttta gaaaaaatcc 1071181 gggcgaagca gcacgatgta tttcaatatc acttcgctct cacagagacc gaagtgaagc 1071241 agattctgtc tgatatctaa aaaacacccg gccttgattg agccgggtgt tacgccatac 1071301 ctttttgaat ccagatacgt gagcgccatc ttctgtacat taagattccc cggacccatt 1071361 catccgcgat aaaagaaatc caaatgccgg caagaccgaa accgaggtgg atgccgaaaa 1071421 gataagcaag cgggaggcca atgccccaca ttgaaatcat tgccatgtaa accgggaatt 1071481 tcgcatcccc cgcggcccgc agagagttaa tgataatgac attaaacgag cggcctggtt 1071541 caaggataat ggtcatggca atcaataggc ttgcagttgc tataatgtca gggctttgtg 1071601 tgaagagtcc gatcaggtct tttgaaaaga tcgtcatcaa aacagaggta gccgcagcaa 1071661 ttccgagtgc ccaatataag ctcttcatgc agcgctcata agcggcatca aattgtttgc 1071721 cgccgatata acggccgatt aagatttgtg taccctggct gatcgcagtg ccgaacagca 1071781 aaataaacat cgtaatattt tgcgtataca cttttgttgt caacgcctgc gcgcccatga 1071841 tggcgataaa atacgtgact atcatttgcg acaggttgta tgaaagctgc tctcccgcag 1071901 aaggaatgcc gattttcagc agcttgcgca aatgctcttt atgcatatga aagacttttt 1071961 tcagcgacat cttcagctgg atgcgtttgt tgacaatcac aatcatcgcg attaatccga 1072021 tgacgcgggc gatagatgtg gacatggcca caccggcaac accgagaaca ggaaagccga 1072081 acaaaccgaa aatcacaaca aagtttccgg caatgtttaa aatgttcatg ccgatagtga 1072141 caaacattgt atcttttgtg tagccgtagc tttttaagat cgcgctgaat gtcatgatta 1072201 aagcctgaat aaaggacaga cctccgacaa cttgtaaaaa gactttcgca tcaggcatca 1072261 gtgcgtctga taatcccatc atatgaagca gagggacagc cgcgaaaaag acgacggcgc 1072321 tgatggccag gctgatgaag aagttggcgc cgattgacac ataagcgact tccatggctt 1072381 ctttcttttg ccgtgagcct agaaattgtg aaatgataac ggtcgttcct gttgcgataa 1072441 agctgaacat cacgataatt aaatttaaaa tctggttgct gacgccgact gctgccacgc 1072501 tgttatccga gtattggctg agcatcagtg tatcggcatt acccataaac atatataatg 1072561 agacctcaat aaagatcggc caagtaagcg aaaataatga gaacgttttg tcagcgggtt 1072621 ttttcaaagc agttgatttg aagacagctt gtttcatcgt gtctaacccc tttcgtaaat 1072681 aaaatcaacg ttttaaagtg tacctccatt tccttataat aaaaagggat agaaacgata 1072741 cttcttgtaa aaatccgact taaaaaggag gatgattcaa atgcctcgca tcctgtttac 1072801 agtcccgcct tttccggtat ttatcgcagc tggggaaggg gtttttaaaa aaggagaaac 1072861 ccatgtgaaa cgtgtattct ccgtgtttga tctgatatat gtcaaacagg gaacgttata 1072921 tataacggaa aatgaaacat cgttttctgt tgaaggcggc gagtacatct tgctttctcc 1072981 cggtcttgaa cactacggga cgaagggcag tgatgaagca acctcctact attggcttca 1073041 cttcgatgaa catcgatatg aatttacggc aaagggaggc agcaactggt ctgagcttca 1073101 gcaggaaaaa gggagcttcg aagagctggc ccgctacgga ttggccttgc cgagaaaagg 1073161 caaggtgcag cgcccgcagt ttatggcgca gcagtttgaa aagctgatcg attactccgc 1073221 ggaaaactct gatttgccgc tcagaaagca aattttattt gaggagctga tgctgcatct 1073281 tcaaaaagaa gcgttccaaa taccgtctgc gaaagagcgg gtagcctggg aggcggcccg 1073341 gtatttacag gagcactata aggaaaagac gacaatcaag gatctgtcgc tcgcccttca 1073401 ctatcatcag gattatgtga gccgctgcat gcagcaggtg ctcggcgtaa ctccggcaca 1073461 atacacgaac cgggtgagaa tgacggaagc gaagcgtctt ttatcctcta caaatgataa 1073521 aatgggcgtt attgcggaaa cggtcggaat ggaagatccg acatactttt caaaactctt 1073581 taagcagata gaaggcattt caccaattga ataccggaaa attgtcagcc ggaaagttca 1073641 ataaccagac gagggatgaa catgaaaaca acaatttacg atgtggcaaa ggcggcgggt 1073701 gtttcgatca caactgtgtc ccgtgtgata aacaatacgg ggagaatcag cgataaaaca 1073761 cggcagaagg tcatgaatgt catgaatgaa atggcataca cgcccaatgt ccacgccgcg 1073821 gcgttaacgg gaaaacgaac gaatatgatc gctctcgtgg cgcctgatat ttcaaatccg 1073881 ttttacggcg aactggccaa aagcattgag gaaagagcgg atgagctcgg ttttcaaatg 1073941 ttgatttgca gcaccgatta cgatccgaaa aaagaaacaa agtatttttc tgtgctgaaa 1074001 cagaaaaagg tggatggcat tatttttgca acagggattg aaagccatga cagtatgtct 1074061 gctttggagg aaatcgccag tgaacaaatt ccgattgcca tgatttctca ggataagccg 1074121 cttcttccga tggatattgt tgtgatagac gacgttcgtg gcggatatga ggctgccaag 1074181 catcttctgt cactcggcca cacgaacatc gcctgcatta tcggagacgg gtcaacgaca 1074241 ggcgaaaaaa atagaatcaa aggcttccgt caggcgatgg aggaagcggg cgtgcccatt 1074301 gatgaatcac ttatcatcca gacgcggttt tccttggaaa gcggcaagga agaagcggga 1074361 aaattgctcg acagaaatgc tccgactgct atttttgcct tcaacgacgt attggcttgt 1074421 gccgccatac aagctgcgag aataagaggc ataaaagtgc cggatgatct ttctatcatt 1074481 ggttttgata atacgatact cgcagaaatg gcggctccgc ccctgacaac cgtagcccag 1074541 ccgataaaag agatggggcg gagcgtcatc gaactgctgg cagaagcaat agagggaaaa 1074601 cgaaaggcga aacaaaaaat agtgctcccg cctgagcttg tagtcagaca ttctacatca 1074661 ccgctcaaca catgagcccg ctaatgagcg ggttttttca ttatgacagt tgaagccaaa 1074721 aaaacatatt gcgtgtaaac caaaggcggt gtaaaatata accatctttt gagaaagcgc 1074781 ttgcgcaaaa tggcagagcg gatagaaccg ctgttttttt agctgttaag agaaaacgct 1074841 ttctcaaagc gagcccgaaa tgagataaag gagaggatgg gacgtggaac atcaagtaag 1074901 atgtgcagta ttgggattag gaaggctcgg ttattatcat gcgaaaaatc tcgtcaccag 1074961 tgtgccgggg gcaaagctgg tttgtgtcgg tgatccgtta aaagggagag cggagcaggt 1075021 tgccagagaa ctcggtatcg aaaaatggtc agaggacccg tatgaagtgt tagaagatcc 1075081 cggcattgat gctgtcatta tcgtaacgcc gacaagcaca catggtgata tgatcatcaa 1075141 agcagccgag aacggcaaac agatctttgt tgaaaaaccg ctgacattaa gccttgagga 1075201 atcaaaagca gcttctgaaa aagttaagga gacaggtgtc atctgccaag tcggctttat 1075261 gagacggttc gatcccgcat acgcagatgc caaacggcgg atcgacgctg gagaaatcgg 1075321 caaacctatc tattataaag gctttacgcg cgaccaaggc gcgcctcccg cagaatttat 1075381 caaacacagc ggtggaattt ttatcgactg ttccatccat gactatgata ttgcccgtta 1075441 tttgctaggg gcggaaatca cttctgtttc aggacacggc aggattctga acaatccgtt 1075501 tatggagcag tatggcgatg tggatcaggc gctgacgtat attgaatttg actcgggcgc 1075561 agcgggggac gtcgaggcaa gcagaacctc tccatacgga catgacatcc gggcggaggt 1075621 gatcgggaca gagggcagta ttttcatagg gacattgaga catcaacatg tgaccatcct 1075681 atcggctaaa gggagcagtt ttgatatcat tccagacttt caaactcgtt ttcatgaagc 1075741 ctactgcttg gagcttcagc atttcgccga gtgtgtccgg aatggaaaaa caccgattgt 1075801 gactgatatt gatgcgacga tcaatttaga agtgggtatc gccgcaacca attcctttcg 1075861 aaacggcatg ccggtacagc tagatgtgaa gcgcgcttat acaggtatgt aaaagctaag 1075921 tatgttgcat ttgaggcttt ccgcaaaaaa agcaagggca ttttagccct tgctttctct 1075981 tttctcatat aaatagtaca tataatcagt aggtacgcct gaatggtcca gctgtctcag 1076041 catggcggtt acgttccctc tgtggtaagt gccgtgattg acgacatgca ggatggtgtc 1076101 tgcataggtt gattccagtg tacctagttt cggatgctgc attgtgaagg tctgttctaa 1076161 gtccgtctgg cggctgaaga aatcatgata ctgtgactcc agctcggcag cgtgctgttt 1076221 aatcgctgcc atattacctt gcgcggactg taatttgcct gcgctgtcta taatctcttg 1076281 gtaggccact cccgaaagaa cattcagcca aatgtagtca gccctgcaca tatgaagcag 1076341 cacgtcgctg acagaaggaa atacgctctt tacttcttga taggcagttt cctccggcag 1076401 gttttcgata tgggtaaata ttttcttgtt tgcccaagaa tgatagtcat aaaactgttt 1076461 tgcatcagtc atcagcatgc ccccttttct aagaaattcg tttttttcat ctgtttctcc 1076521 ttcaattgca aaagagtgac accccaaaat atcctgccgc tgcccacatt accgctgcag 1076581 agcatttgtt tacgatcagc ataagcctgc cgctcgtatc tatcgtctga aacaaccggc 1076641 ccgctattgc aaggctgatg aaccaaatcc aagacacagc gatgcaggcg gccataaaga 1076701 gccatttctc aagccccgaa tattgaagag agctcgtgcc gatgacgccg atcgtgtcca 1076761 gaatggcatg cgggtttaaa agagaaacag cggccgcaaa cgcagcttgc ttttttggtg 1076821 tgaacgtatg tttctcattt tggcttgtgt tcggacggat gttccaagtc acccagccca 1076881 tataaagcaa aaataaaaat ccgccggcca tcatgactgt ctcaaacaca ggcagctcct 1076941 gcacaatgac agacacgccc gcaacggcta atacaattaa caaggtatcg cagactgaag 1077001 cactgatgac agctgggaga gcccgccaaa tatgcttttg caacgcgcct tgctgaaaaa 1077061 taaacacatt ctgcactccc agcggcaaaa ttaagccaaa cgcgagcaca attccgtgaa 1077121 tgattgcatt catgctgaaa aagctccttt cacatttttt ttcaatcata agagagattg 1077181 tcactaaagt ctccagccat ttggttgggt taggaaccag ccaaatgtat aatgtgtaaa 1077241 aaaggggggc atgaccttgt cgcaatggca gccaagccga aagtcggatg ttccgctgca 1077301 tcggcagatc gaacaatata tgaaagacaa gattcttcac ggagagtggg ctgtagggac 1077361 gaaaatcccc tcacagagaa cgctggccga catgtttcaa gtcaaccgca gcacagtcac 1077421 agcagccata gatgaactca cgtctcaagg cttgttagag ggaagaaaag gcggcggtac 1077481 gaaggttgta aacagtactt ggagcgtgct gacggctgag cctccgcttg attggagcga 1077541 ttacgtccgt tcgggcattc atcgcgccaa ttcttccatc attcaagcta ttaatcagaa 1077601 cgaaccaaga gcggatatca tcagattagg aactggagaa ctttcaccgg atcttgtgcc 1077661 tgctgacaca attggacgga tgtttcagca aatcaatccg ggcgtcctgt ctttaggata 1077721 tgagcagccg aaaggaaacc gtcagctgcg ggaggcagtg gccgaccatt taaaaggaaa 1077781 gaagatccat gtgtcaccgt ctgcaatttt aattgtgtcc ggtgcacttc aggcacttca 1077841 gctcatctca attggacttt taaaacgaga ttctgtcatt ttgacggaga agccgtccta 1077901 ccttcaatcc ttgcatgtat ttcaatcagc tgggatgcgg cttcgcggct tgccgatgga 1077961 tgatgaaggg gtcaaagcgg ggcttgtttc ttctaatcga aaacaatatg gaggacagct 1078021 gctttacacg attccgtcgt ttcataatcc gacaggcaca gtcatgtcag agcagcgaag 1078081 gaaagagatc atcagcctgt caaaaaaaga gcagatgccc atcattgagg atgatgcgta 1078141 cggtgattta tggtttgaag aaaaaccgcc gcagccgttg aaagcaatgg atcatgaggg 1078201 caatattctg tatctgggcg cgttttcaaa aacggttagc cccggtctgc gaatcggctg 1078261 gcttgccggt ccggagccgg ttattgaaag gctggcggac attaaaatgc agacagacta 1078321 cggatcaagc ggcctgtccc agtgggcggc tgccgagtgg ctgtcacagg gatattatga 1078381 agagcatctg acttgggtac gcaggaagct taaagaaagg agagacgccg ccgttcattt 1078441 tctcgagcgg tatgccgggg acattgccac gtggcggatt cccgcaggcg gcttttatat 1078501 ttgggtgaca tttcacaaaa acctgcctgt cagccgtttc ttttatgaat tgctgaaacg 1078561 gcaggtgctt gtgaatcccg gctatattta tgacggtgaa gaccgaaaca gcatcaggct 1078621 gtcatattcc tatgcatctc ttggagattt ggaaactggc attaaagcgg cagctgaaac 1078681 agcacgccgc ctgatgatgt cctaggcttt ggttatacga tgacagctcc cagtgccctg 1078741 gcgaaggcaa tcgcgtgctc aggtgcgatt ttgcagcctt tcaatttgtc gagggagaca 1078801 tgaagctgtt caaaacggca cgtgctgatg tccatgtttt gaagggacgt gccggtaaag 1078861 ctggcgcctt ccaattcgca tccgtcaaag tgtgtctgct ggagcaccgt atcgctgcat 1078921 tcactttgca taagagcaca gtgatcaaat cgaacttgtt tcatatttga gtacgaaaat 1078981 gagctgaaat gtccgtggca ttcctcgaat gaaacattcc gcagcgttgc ttccgccaca 1079041 ttcattccaa ccatttttga ctgcttaact gaagttctgt gaatgacagc cccgctgaaa 1079101 tcggcgtttg ataaatcgca tttttcaaag atcacatcgg tcagttcaat atgccgaaaa 1079161 gacacatcga taaagacgac atttctgaat accgtttttt caacacatag tctttcgata 1079221 tcttcgccgc agatggtgca atcttcaaac aaatgcatgc tgattacatc atcctgtgtc 1079281 acggcatcat gaaaatctgc ggtttgcagg ttttccggta tgttcggttt ttgaattgcg 1079341 attttattca tgtgatgaca tcctttgctg cccgaaaaac agaggcttcc gggttcaatt 1079401 taatagatcg ttaaggaaat tgatacatat agtaaatcgt gaagagcctt ttcttggtac 1079461 agcagcccgc ttgttttgta agcataaatg gaaagcttcc tatacgtcaa ggcgtttaca 1079521 ggccgaaaaa gccaaaggga acaggaggaa tgcggaatgg ggcattacat caaaaccgag 1079581 gagcatgtga cactgtttgt agaggatatc ggacatggaa ggccgatcat ctttttgcac 1079641 gggtggccgt tgaatcataa gatgtttgaa tatcaaatga atgagcttcc gaaaagggga 1079701 tttcgtttta tcggcgttga tttgcgggga tatgggcaat ctgaccgccc ttgggaaggc 1079761 tacgattatg acacgatggc cgatgatgtg aaagcagtca tttatacgct gcagcttgag 1079821 aatgcgattc ttgccggttt ttcaatgggc ggcgcaattg caatccgtta tatggcaagg 1079881 catgaaggag ccgatgttga taagctgatt ttactgtctg cggcggcccc cgcgtttaca 1079941 aaacgcccgg gttatccgta cgggatgagg aagcaggata ttgacgatat gattgaattg 1080001 ttcaaagctg atcggcccaa aacactggct gatttaggga aacagttttt tgagaaaaaa 1080061 gtgtctccag agcttaggca gtggtttctc aatctgatgc tggaggcttc ctcctacggg 1080121 acgatccact cgggcatcgc attaagagac gaagatctca gaaaggaact tgctgcaatc 1080181 aaggtgccga cgctgatcct gcacgggaga aaggatagaa ttgcgccgtt tgattttgcg 1080241 aaagaattga agcgcggcat caaacagtcg gaattggttc cgtttgcaaa cagcgggcac 1080301 ggagcatttt atgaggaaaa agagaagatc aacagtttga ttgcgcagtt ctccaactca 1080361 taagaaaaaa cccgacattg atcgggtttt ttatataatt cctctgtttt gcagtgcgtt 1080421 aatgatgaga tcagctccat cggaaataga ggtctggtca gactcaatga tgaaatcggg 1080481 tgaaagcggc gcttcatacg gagaatcgat cccggtgaaa tgtttgatct ctccgtttcg 1080541 cgctttttta taaagccctt ttggatcgcg ctgttcacaa acatgcagcg ggcacttcac 1080601 ataaatttcg aagaactcac ctttaggaaa gagcgctcta accatgtccc gatcctctct 1080661 gaatggagaa ataaaagccg ttaaaatcat ttgcccgctg tcgacaaaca gcttcgccac 1080721 ttctccgatc cggcggatgt tttcaatcct gtcaccagtc tgaaatccaa gatctttgtt 1080781 taagccgtgg cggatattat caccgtcaag cacgtagctc tgaatgccct tgcggtaaag 1080841 cttttcatcg acagcattgg ccagcaccga ttttccggag ccggacaaac ctgtaaacca 1080901 aaggacgcag cttttgtgtc cgtttaagga ctgtctgtca gactttgaga tggcagcggg 1080961 atgccaaatg atgttcggat tgtgtgtcat tgcaattccc cgctgttttg cttgatggca 1081021 acaggctgtt ggtgaagtcc cttgatcagc acggctgcga cctcaggccg gctgaattct 1081081 ttaggcggct ttttgccttg gcggagaagc tctctcactt ttgtgcctga taagtggatg 1081141 tggtctctcg ggctgtgcgg acatgttttg gaggtgccca tgtttccgca ttttcggcaa 1081201 taaaagctgt gctcaaaaaa cagcggcttg atgcccagct cttcctctgt gaatgattga 1081261 aaaatatttt gggcgtcgta tgttccatag tagctgccga cacccgcgtg atcacggcct 1081321 acaataaaat gggtacagcc gtaatttttt cggacgagcg catggaaaat cgcttcccgc 1081381 ggacctgcat aacgcatggc ggcagggaaa accgataaca tgacacgatc ctttggataa 1081441 tagtgattaa gcaaagcctg gtagctctcc attctgatat cgctggggat atcgtctgac 1081501 tttgtttctc cgacaagtgg gtgaagcagc agaccgtcga ccgtttctaa cgctgttttt 1081561 tgaatgtatt catgcgctct gtgaacaggg ttcctggttt gaaagccgac aatcgtcttc 1081621 cagccgagtt tttgaaaggc cgctcttgtt tcagcgggcg ttgcataaaa ctgttcgaaa 1081681 gatttgtcag gcaggctgct gaccgtgata ggccctccga tatagtaatc cgggcgcgcc 1081741 agcaattttt ttacgcctgg gtgggcagga tcgtttgttt taaaaacaga cagtgcttct 1081801 tgtgttttat caggctggta tatatcggtg actgtgatca tgccgtaggt aacaccgtct 1081861 ttcacaagct tgacgtgatc tccggcagac agctgtcttg ctgttttttc tccgacaggc 1081921 agcgtaatcg gcaggctcca cggcaagccg tttgccagcc tcatctcttt cacaacggaa 1081981 tgataatctt tttctcccaa aaaacctgtt aacgggctgt agccgccgat cgcaataagc 1082041 tccagatcac tcagtgcaag ctgatccagc tctgcttggc acgcgcaccc ttcaaaatgg 1082101 catgcgggat cacagcggtt gattaatacc cctccgtggg gttcgtttcc attcaacgtg 1082161 ttcaacctcc atttatacgt ttccttgttt tcttttctgc acttaatgaa agtttgacat 1082221 cagcgcctta acatcatttc gattctcaca tcaagaacct gccatccgct attcttgatg 1082281 caggccgcat tctgttttct cccgtccggc ccatcttcca gccctctcat cgttcgggtc 1082341 cggggaaggc agtgtacaca tttcacagcc tatgctcgga taatgttgat cgtgcagttt 1082401 gttataaggc aaattgtgca ggcggatgta cgtccaaacg tcatcccatg tccagtggat 1082461 aagcgggcaa attttgatga gctcaaactt ctggtccagg tttacgtatt gaatatgctt 1082521 tctcgttggt gactgatccc ggcgcagtcc tgaaatccaa gctgtcatgc cggacaggtg 1082581 ctttttgagc ggttcgattt tccgcaattg gcagcagagg ttcgggttat gcttccacag 1082641 ctctccgccg tacttcgtcc cctgttctgt taagctcagc tcgggttcga gcatctggat 1082701 tgcaaatccc ggatatcgtt ctttgacggt ctcgatcagc tcatatgttt cctgaaaatg 1082761 aagcccggta tccaaaaaga tgatgtgtgc gtttttgttg atttttgata ttaagtcgag 1082821 aagcaccatt ccttctgcgc caaagctgca ggcgtacaca atcttttctc cgtacgttcg 1082881 gtaagcccat ttcaacacat cgagctcatc gatcaattga tccgttatct gtttggacag 1082941 catgtcgttc caagtgtcat atgtgatggt ttcgttcaat gttttccccc cgtttgcatc 1083001 tgcttttttt atctattgat cgagttatag gcagactatt cattttttgc ataaaggttc 1083061 aggttttagg tgccgcgccc gcctaaaatg aggtgcggaa ccattaagag cccggctgaa 1083121 tatgcttttt agcaaaatgg ttttatgccc aaggagaggt agtatgccga ttgccattta 1083181 tcaggggcat catcattcgc ttgccccggc ggacattaac atcgtcattg atgtcatcag 1083241 agcctttacg gtcgcccatt atgcgtttat cggcggggcg aaagagattt tgttggtccg 1083301 gacagctgat gaagcctttg cgctgaaaga cacctatccg gattatgttt tgacgggaga 1083361 ggaaaagggg gtcggtatca gcggatttga tttagataat tctccaaaac gtatggctgg 1083421 gcagaatatg acggataaaa gcctgatcca gaaaacaaca aacggcgtca cagcagcatt 1083481 gggggcgctg aacgcaaagc atctgttcgt aactggattt tccaatgcca aaacaacggc 1083541 acagcatgtg aaaaagctcg tcgcaaacga ttgtgtcata aacatagtgg cttcccatcc 1083601 atccggtgat gacgatatgg catgtgcgga gtatatcaaa ggcatcattg aagggacaaa 1083661 tgtggtaacg gctgcggagg cgattgaaag aataaaaggc tcttctgttg cggagaagtt 1083721 ttttgactgc cgccagccat tgtttgattc ggaagacatc gtttactgta caaaagaact 1083781 gacgggcgat ttcgtgatga aagtgaaaca agatggagaa gttccaacga tagagagggt 1083841 cataatatga atgatttttc actagaattg ccagtgagaa caaacaagcc gagagaaacc 1083901 gggcagtcca ttttaattga taacggctat cccttgcaat ttttcaaaga tgcgatagcc 1083961 ggagcgtccg actatattga ttttgtgaaa ttcggctggg gcacatcatt acttacgaaa 1084021 gatcttgaag aaaaaatcag cacactgaaa gaacatgaca ttacattttt ctttggcggc 1084081 acactgtttg aaaagtacgt aagccagaaa aaagtgaatg aatttcatcg gtactgcacc 1084141 tatttcggct gtgaatatat tgagatttca aacggtacgc tcccgatgac aaataaagag 1084201 aaagcggctt acattgccga tttttctgat gaatttcttg tgctcagtga ggtgggcagc 1084261 aaggatgcgg aattagcaag ccggcaaagc tctgaggaat ggcttgaata tatcgttgag 1084321 gatatggaag cgggcgcgga aaaagtgatt acagaagcca gagaaagcgg aacgggaggg 1084381 atctgttcca gcagcggcga tgtcaggttt caaattgttg acgacatcat ttcctcggat 1084441 attgatatca acaggctgat ttttgaagcg cctaacaaaa cgcttcagca agggtttatt 1084501 caaaaaatcg ggccgaatgt gaatcttgcc aatattccat ttcatgatgc catcgcgttg 1084561 gaaacgctgc gtttagggct aagatccgat accttttttc tgtaaaatag cggctgcggg 1084621 gctctcgtcg tgaagagagc ctctgcctat tattttttat ggcggtacat aggcgtgaga 1084681 tagggaagtg aggtcaggcg gatgttgtag atgaagtcga tgactcttgt cgatatcacc 1084741 tggcatatga gggcttgaat gacgatgccc cagtcaataa tagacgcggt gaccataaaa 1084801 atgatgcaat tcatgatgag caggatcgtt ccaggattcc cgccgcggta gatagaaatc 1084861 atcagagcaa gggctccgaa tcctccgttc gaaattttat atttgtataa aagtccgatt 1084921 ccgagtccca ataacactgc gccgcttgcc agatcaagcc acaggttaga tgtgatatca 1084981 ggaaaaactg catcaaagat caataccgag acagaggtga cggtgataga agcgagggtg 1085041 ccggtgaatg ttctcatctc cagccatttt aaagcggtaa aaagcattga tacattcaca 1085101 gcccacactg aaaatccgtg ggggatttga aacagataat gcaatagcac cgcaatacct 1085161 gctgcaccgc ctgtcggaat atcatgcgga aataaaaaca aggacatgcc gagtccttgt 1085221 agtacgccgc ctacgacaat cataaacgta agttttgctt tcatcagcag ttcagccatt 1085281 aagtcatttg ctcctttatg aaaagacttg tccgctgttt tcattttatg aggctgtcca 1085341 ttatttatgt ctcaaaataa agaaatggcc cagcttaata ggctgagcca tcccacttgt 1085401 agcgattgac gatctccata ttgatctctg tgccaatgcc ttttcctttc gggatgtgga 1085461 ccattccttt tgaaggctgc aggctgacga gatctgtaaa aggattctcc atgacgtccc 1085521 actcgatcgg ttcaatgtga tcgttcttca ttttagacca tgggggcaga caggcttgtg 1085581 caaataaagc atagagccgt gagagcgatc cgtcatatgc atgggcggat gctctgacgc 1085641 cgaaataacg cgcgagctgg aggcagtccc gaaactcatc aattccgttg acatgcatga 1085701 catcgggctg aatgatatcc aaacagcgct gtgaaaggag aggcacatat tgcgccgggc 1085761 ctttcatgtt ttctccgccg gcaacaggaa cagacaaacg gcttcgaagc atagcgtaat 1085821 cctgcggctg atcaaagggc aaaggctcct caagccagcc aatgttcgtc cattcggaga 1085881 aatagcgctc ccatttaaaa gccgcagcgg catcgtagct ttggtttgcg tccagaatca 1085941 tcgtaatgga gctgcctgct gtatgctgca gcgcattgat gtgccggaca tcctccttga 1086001 atgaagtccc gccaattttg actttgattt gctcaaaacc ttttttcaac tgggcttcaa 1086061 cattggagac tgagcggctg atccattgcg gggagtctga gtacgattga aaagacgcgt 1086121 acacaggaat ctcctctctg tatcgcccgc cccataattc gcaaaccgaa caatccgcag 1086181 ctttggctgc aatctctgtc agcgccatgc ttacagcgga ggccgcccgc tggtgccatt 1086241 tttgaatcgt gcgcactaat gacaggcggc tgccagcctg ttttcctaat agaaatggga 1086301 tgatccgctt cgtaaaaccg acatggagag cagggagcca atcaacgcat tctccccagc 1086361 cgtctatccc gctttcggtg ataatcctga tgagataaca agtccgatat cgtttaaacc 1086421 cattggcatc tccgtatggc ttttctaatc gatgaaatag cggaaaggtt tcaatccgta 1086481 caattttcac actgggtgct acctttcctc agcgggctgg agccgattgc cagccatttt 1086541 agggtcttct ttttcttttg tttcttcatt gttttgcttc acatggatga gcatcatcac 1086601 aagaatcccg acaacgagag tcaatcccgc gatgcttaaa aacatgccgg gtctggacca 1086661 ttgcatcagg cggccgaaaa tcggaggacc gatcgctacc cctaagaaac gtacagagcc 1086721 gtacagcgag gtgacaaatc cccgtctttc tttgccgaca gccccggtaa tgaaactgtt 1086781 cacacaagga aggacaagac ctgagcctat actgctcagt acaagaacac tgataaaaag 1086841 gacaagattt tcaatgaatg acagtgccgc gtaggatacg gtcatgaacg ccaatccaag 1086901 tacgatcagc tttttcatta acgattgctt ttgcccgatt ttgcttcctg ttgtatagga 1086961 cgtcacacac ataaccaaaa gcgggatcgc taaaattaag ccttttttca cgccgtcggt 1087021 gtcgtatgtt ttttcaagaa catctgagag ataaaacagg atgccgaata aagtaaacaa 1087081 acaggtcgca ccggctaaat aagcggtaaa cagccatctg ccttcatgtt taaagacact 1087141 taacagccct tttgcatatt gtccgattgg tggcggttct ttttcctttt tcttttcttt 1087201 aataaaaatc caagtcagta cgatcgaaat gatacaaaac acaggaaagg caaaaaacgc 1087261 gccataccag acaagcaggg cgatcagcga gccaatgatc ggcgatagca ctttccccat 1087321 gccgtttgaa gcttcaacaa ggccgagcac cttgctctcc tgggcgcctt taaacagatc 1087381 tcccgtcagt gccatggcaa ttgggccggt tccggctgcc ccgattccct gtaacgctcg 1087441 tcctgccatg acccaaggat aggcattgtc aaaaaaacct gccgcaaacc cggctaacaa 1087501 accgccggca ccatacaaaa ttaagcaggg aataatgatg actttccttg agaatcggtc 1087561 tgcgagataa ccgacaatcg gaatcgcaaa tgctgcaatc aaggaaaata ctgtgatcac 1087621 gagactgact tgaaattgtg ataaatgaag ttcagatttc atttttggca aaatcggaat 1087681 aagcatcgag tttcctaggg ttaatattaa agggattgaa ccgattgcca caatcgtcat 1087741 tccgttattt tgttttgatg attccatctc agagcacact ccttttcttc tgcttagaat 1087801 gtccctgatg gcttcgttta ttcagcgatc agacagcaaa aaaccgaaca gaagatacct 1087861 gttcgggaaa aaagagggtt aaccgagagc ctgtgaaatc aaagcatata agtgtccatt 1087921 ttgaataggc gcttttttct gatagaacaa aatcggaggt tcatcatctt tatgaaatcc 1087981 catttctatc aggctgtcat gcagagacgt gtgttcactc ggtatatcga ttcgcatcgg 1088041 cccttgtttg ccggccgcca gccttgtaat tatctgtgct gcaacatctg atgatggagc 1088101 gatgataggg ccgaatttca aattggccgg tgtctgtaca gaaagtccgt agccaatgag 1088161 ctgtccgtcc tgatttctgg cgatgataca ttcgcatgaa gcagaaataa gctgctgcaa 1088221 aaggtttgat cgatctccgc caaaggcagc cagatccgcc gcggttaagt cgtgaaagtc 1088281 ttgttctcta aaggatgtca gttcagcatc aagctttttt gtataaggtt gaaaactgtg 1088341 acagctgtac tttcgcactg aacctgccgt atgaaaacct gctttttcat aaagcggcaa 1088401 accttctttt gtggcgcaaa gcctgatggc ggtgttttca tccgtttggg taatacaggc 1088461 gtttaccata cgccggccaa gaccgagccg ttgatattcc ttgtcaacga taacaaggcc 1088521 gatagaagta agacggccaa acaaaaacaa gccgatgcag gaaataatat caccgctgac 1088581 attttgataa ccgaaaaagc gtccctgctg aacaagcagt ttcagctctt gttcgccata 1088641 atccggccac ccggcttgcc cgcaaagccg caataagccg gaaacgtgtt cttcatgaag 1088701 cttaatcagt tcatctacta cgtccataag atcacctgct tgttctaagt gttttgtaca 1088761 tgacaatatg attgccaatg ccgggaatgt caaatggttc gccaagttcc ttccagccaa 1088821 gcttggcata gtagcccttg acatggtgtc ttgcgttgca ccataccgcc tgaacgccgc 1088881 tctccgccag tttgtgctcc gcgtgtttga tcagcgtgct tccagctttt tgatcgcgat 1088941 atccctcgag cgttgccatg cctctcagcc gatacgcaga ggcttccgtt aataaaggct 1089001 gactttgcgg ggaaaaagaa gcgatgctga tcagcgttcc atcataaaac acgccgagat 1089061 gaaaggagcc ttctgcgtga tcctctttat atttgcattg ttcgatggat tgatggggac 1089121 gcagaatgcg atgccggatt tcatatgtat cttccacgga aatggttttg acttcgagca 1089181 taatgttcct cctcatgatt gtttttctat atcgtaacac gaatctcgtt gaaaaagact 1089241 gcccgattcg atcaggcagt cttttggaaa ttaatgcaaa aagatatttt ggcgctgctc 1089301 atctttttgc tgaatatatg atgtgagctc agcggttaag tcagatctga ggaaaggcgt 1089361 tatcaagtag atgccgttaa acagctcgca tgccgtatcc agcagggagc gtgcaattgc 1089421 aaggccttcc gccttttgct tttctttatc ttcaccggca tgggccattt tttcgcgaat 1089481 cgtatcagac agcttaatgc cgggaatttc attatggatg aattcggcat tccggctgct 1089541 tgtcagcggc atgatgccga tatagatcgg cgtcttcaga tgttttgttt cgttatggat 1089601 atcgacaagc tgctgctcgg aatagacagg ctgagaaaca aaataatctg cgccgcaatc 1089661 tatttttttc tcaagccgtt ttaccgcttt atccagatgg cggacgttag gattaaatgc 1089721 ggcggcaact gagaaattcg ttttcttgcc gagcggtttt ccagacagag acagaccttc 1089781 attgaattgt ttgatcagcc tgattaaatc aaaagatgtt aaatcatata cagacgtcgc 1089841 cccaggaaaa tccccgattt tagaagggtc acctgtaata gcaagcacgt cattcagccc 1089901 taacgtatca aggcccatta aatgtgactg taagccgata atgttacggt cacggcacgt 1089961 aatatggaca agggaacgca tatcgagctg ctgcttgaca agggcgccgc aggcaacatt 1090021 gctgatccgc ggggtcgcca aagaattgtc ggcgagtgtc agggcatcga ttcccgcttc 1090081 ttttaattca gcagcagcgg acagaaattt gtcaaagctt agttttttcg gcgggtccag 1090141 ctctacgata atagagcgtt ttttcgctgc gatctcatcc aggccgggct cggttcgctc 1090201 gtgatgaaca gaaatgaatt ctttcgcccg ggttttgact tctttttccg taatcggagc 1090261 cagcccgcca accgcttccg ccatcgccct gatgtgattc ggcgttgtgc cgcagcagcc 1090321 gccgataatc cgcgcacctt gcttacggaa ttctgacgcg ctgttttgaa aatacgtgtc 1090381 gtctgtttca tagacgagcc gtccctcttc aagcgaagga agactgctgt tcggataaac 1090441 ggataagaat acgtcatcaa aaatcggcac ttcgcttagc gcttcaatca tgtgataagg 1090501 gccgaggcgg cagttaatgc cgacaatatc agctccgaga tccgcaatcg agcgcaatgc 1090561 gtcagaaagc ggcgttccgt cctgcaatac gccttgctcg tgcatggaga cattgagcat 1090621 aatcggaaga tcagtctctt tgcgcgcgat tttcagcact tcacgggctt cttccaaatc 1090681 ataatatgtt tctaacagca agccatccgg ctcttcatgc agcagcagat acagctgctc 1090741 gcggaagctg cgcttaattt cgtcaagact gtatgcgttt ttattaaatg tgcgtatgcc 1090801 gcccatcgtt ccaagcacgt atgcatcgcc tgctgaagcc cgcgcgatct ttacggcctc 1090861 ctgattcatt tttttgatgt catcctcaag cccgtgtctg gataatttaa tatagttggc 1090921 tccgtacgta ttcgtttgaa taatgttggc tcccgcttca acgtacgctt tatgtatgcg 1090981 ctgaatttcc tccggctttg aaatattgag ctcctcaaaa cacctgtcaa tgccatagga 1091041 gtagaggagc gtccccatgg cgccgtcacc gattaacacc tgtctttgca aatcttctaa 1091101 aagtcccatt gtctgcctcc tttattcaca tcagcaagga aaaaagagaa ataaaaaaag 1091161 tcctcttaag aagaagactt tgtcagtgat tttgtctctt cttatcttcc aagctgttcg 1091221 agcttgctgg atttagcacc ttggtcatgg ctgatcgcca ttacaccggt tgctgaagct 1091281 tcgtcgggcc agtccctctg cttctcttga taagaacgga tatgaaattt tcgtgtcagg 1091341 aagtgccaaa agatatctgg cgtttttccc tttctccaaa tttaccgaaa ataaagacaa 1091401 taatcaatag gaatcagaaa atttatctga aatttataaa ttgaacgtca attggcagat 1091461 ctgctccccg tacagctgag ataatctgct gcaggtcatc tttgtttttt ccggtgacac 1091521 gcacttgatc atcctgcacc tgagacttta ctttcagtcc ggagtttttg atgatcgtat 1091581 tgattttttt tgcgttgtcc ttgtcaatgc cttgaacaag ctttgcacgc tggcgcaccg 1091641 ttccgcctga cgcgttttca accttgccgt aatcaatgtt ttttgtcggt acgtttcgtt 1091701 taatcaattt gctgaccagc acatctttca gctggcttaa tttgaattcg tcatcggaaa 1091761 cgaggaccag ctcctcttta tctaaagaaa tgtcgctttt gctgccttta aagtcatatc 1091821 gggtactgat ttccttcagt gcgatttgga ttgcgttttg cacttcaggc aattccacct 1091881 tggatacaat atcaaatgaa ctttcttttg ccatatgaaa acctccataa catttaactt 1091941 atgtgttgat tatagtagaa taaagagaaa cttccaacag aacaaagaat caatttgtga 1092001 tgattggaaa aaatgttaac aaaatccgca gagaataagc ggaacaggaa ggacgatagc 1092061 atgagaccag ggcagcaatt aaccttgagt atagatcacc aaaccgactt cggttacttt 1092121 ttaaccgatg gggaagatac gattctctta cataacagtg aaatgactga ggatatcgag 1092181 gacagagacg aagtagaagt ctttatatac gtagaccagc aggaaaggct tgcggccacg 1092241 atgaaaattc cgatcatcag cgcggatgaa tatggctggg ttgaagtggt ggataaagtg 1092301 gaagatatgg gcgttttcgt tgatgtcggt ttatcgaagg acgcactagt cgcaactgag 1092361 catttgccgc cgtacgaaga tgtctggccg caaaaagggg acaaacttta ctgtatgctg 1092421 aaggtgacga accgggggcg catgtttgcg aaaccagcgc cggaagatat catcagcgaa 1092481 ctgtttaccg acgcttcaga agatctgatg aataaagagc tgacaggtac ggtgtacagg 1092541 ctgatcgcat cgggttcatt cgtgatcacg gatgacggta tccgctgttt tattcacccg 1092601 tcagaaagaa aagaggagcc aagactgggt tcaagagtca caggccgggt gattcaagtg 1092661 aaagaagacg gttcagtcaa cttgtcgctg cttccgagaa aacaggatgc aatgtcagtt 1092721 gatgctgagt gcattctaac gtatatgaga atgagaaacg gtgccatgcc gtacagtgac 1092781 aaaagccagc ctgacgatat cagagaacgt tttaatatga gcaaagccgc ctttaaacgc 1092841 gcgctgggcc atttgatgaa aaacggaaaa gtgtatcagg aaaatggatg gacatacgag 1092901 aaaaaatagc atgaaaacgg ctcgcctgca gcagactgcg gagcgagccg tttttttatg 1092961 tctagtttaa ttcatcaacc agcgttctga ttgccatttc gcgatccaca ttgtctgaaa 1093021 tcgcaatcgg cgtaatatca atggcgagaa tgatcagaat cagggcacct gctgcagcaa 1093081 cataagaaac ataatagaaa tagttagcgg tatcaacagt gttgacaagc tcggcctgaa 1093141 ctctggatgt atcatcctta gaagcggcga tttcctttgc agcttctact ttttcttcaa 1093201 cgatttgacc tgcttttttc agcagttcat ccactttcaa tgcatctttg ctgtaaacag 1093261 ctttcttcag gttatcaaaa aagtcagcat cctctttttt aatatcagcg acaacctgat 1093321 tggcaaaagc ctttgcctgt tttgtgttga gtttgtctgt catcgcttta ttaaagacct 1093381 ctggaagctg tttgccaact tccccttggg caaacacaaa gcctttaaaa atttcctcac 1093441 ctgaatactc aagctgcttt gcctgtgcca cactttcttg ctgcttcacc aaaaacacag 1093501 tcgtcaccaa tacaaccgac aaaaatacta gaaacgcctt cttcaaactg aaacctctcc 1093561 cttcttgtgt tttttattcc acaacagtct gcgaatatat gtaaattgaa tcgtggaatc 1093621 gataggagtg agatacaata tcaaaatgcc ggccatgata atcgaaaaac tgatgaggcc 1093681 cagcatgact gcaaaaatct catgcataaa aacagcgatg atcaaaatca atctccaatg 1093741 cttcttcggc gcaaacagtg ccgcgaagat gacaatttga accagcagcg tcccccatgt 1093801 cggaatcacc acgaacggac ttgttacaat tggcttcgtt aacgcctgaa aaaagccgtt 1093861 gaagccaatg gttttttcct gggcgaaata atagacggcc gttccgtcca cccattcctg 1093921 ctgagatagc ttagcgacgg tagagtgaaa ataaagcacc gccacttgga ttctgatcac 1093981 aaaataagaa ataaaagctg ttatttttcc aagtgttctt ttgccctcta taggtctcgt 1094041 actccaatgc cattttctcg gatcggtcag cgtgatggga agcaataaaa aggtcatgac 1094101 tgctgctgcc tgctcgcctc cgtcgatgac gatcagcgat gactgcaggc tgtaactgac 1094161 ataccaatgc agaaccccgg tgattctggg gcgccagcca atgacaacaa gcaccagaat 1094221 ggcaatgcag acccatctga aaagatttaa catcatatag ttattttcgc cgagacaaaa 1094281 gagactgaga ttcattttac aagctggata gctgctgatc ccgctggctg gcttcataat 1094341 gaggctcggg tgattgatga gcagcgtcag caggctggat agcgcaatga tgcttcgcgc 1094401 gaggccatat acatttgtcc acgggtttct ttcgtcccat ctggtgatgg tctgttttat 1094461 gttttcgagc atgagatcac aaccttgact atgcttttta cctgataaga cgaaggggta 1094521 tatttagaat agctccaagg aacaatatcc tctttcgtca aatagtagct gccacaaagc 1094581 agcgggcggg gagcgggtgt ttttaattgc acggttttgg ctttgctttt gcatgcgccg 1094641 aggtcctttt ctttacatgc tgtccactgt tccttgccga cttggctgta gatcacgccc 1094701 atttcaacgc cttgtgaccg cccataccga tacaggccga ataggttgtc agccctcata 1094761 ttgggccatc tgaccttggc gctggcattt tcagcctcat ataagccgat tgcagtatca 1094821 cgcggatttt tgctaaaaaa gccccagccc tgagggagga tgctggacat gagaaatttg 1094881 gagtcctttg tcagcggaat cggggttgtc cctaagctgc caataataga aaacagaaat 1094941 agcgaacccc aaaggattga aaaaatgaca aaaaatgata tcgatttctg cattcgactg 1095001 ctccttttaa cctgaagaat cgtttttaca cttttcataa tataaaaaca tttatgtaat 1095061 aaaaaggtta aaaagtatga gaaattccat ttttgttaaa aggaaaaaca ggacatttta 1095121 cactgctata tgtgattgat atatagtgtt tttttcgata tatttaaacc atgaaaacga 1095181 atcaagttaa tgaccgctgg attgttcaat ttcgaaaagg gattttcgag ctggccatcc 1095241 tatcccttct gcgttctaaa ccgatgtacg gttatgagct gacgtcatcc ttaaaaacca 1095301 cctcggcgct ggctatttca gagggagcga tttatccgat tttgaaacgt atgaccgaga 1095361 agggatggat cgaatttttt tgggaagatt cactggacgg cccgaaaaga aagtattaca 1095421 aaatgacgca aaaaggagaa gaaatgttaa aagaacggct ggagaaatac ctggaaaccc 1095481 atcaagcctt actgtcttta tcgggggatt tgctatgaat ggacagctta tcattgaccg 1095541 atacatggag gaactaaatg cagagctggc gaatatgcct gatgtagaga gagaaaacgc 1095601 tatcgacgaa ttaaaggggc atatcaccgc tttcgttcaa gacagaatca aagccggcct 1095661 tagtgaagag gaactgcagg aagctgttga atctgaattt tctcatccga aggagcttgc 1095721 cgaattgatg atgggtgatg ggggagagac gaaaaggagg aggtctttat tgggcaaaag 1095781 ctggatttcg gtccttctca ttgtcacgat tatcgccctg ccgctgctgc cgtccgactt 1095841 cagacatctg ccgctggctg tttatttaat ggtgctcgcc ggatatgtat ggaagcggaa 1095901 aaaattggtg atgtttgcag gtgtcagaaa aaacaaaatg cgctctcaaa aggagattgt 1095961 caagatttcg cgagtcggtg cggtttatct gctgttttta gcagtggtgc tccttttgag 1096021 cccgttcctc aatgcgcttg tcgtcctgct gctgattgca gtaagctgcg ccgctttttt 1096081 tctttttctt aacatcaagt aatcttgtag gaggctgtaa gatggaaatc agcatcaatt 1096141 atctattaat tgtcatcgcg cttttattct ttgtggttgc ctattttgtc ggaatcaaaa 1096201 aacaaacctg gatgttggct gggtttaacg aggcgcgtat acgggataaa gatcggctgg 1096261 ccagaatagc aggctacttt ttcttgaatt ccggtttgtt cattttgctg aatagtttta 1096321 tctcatttca aggtcaggag cagctcatac ctccgcttat actggcatat ggagcagggg 1096381 ttattattta tgtcaataaa aaattagtag agtagaaaaa gaagggcaga gcgaaatatc 1096441 tctgcccttc ttttttggga aaataagaac gaagcaccac atacaagttt ttgtattttt 1096501 gataggatga agaaaaatgg tagattccaa aataggaagg atgtggtgtt ttgcgcaact 1096561 tgaccaagac atctctatta ctggccggct tatgcacagc ggcccaaatg gtttttgtaa 1096621 cacatgcctc agctgaagaa agcatcgaat acgaccatac gtatcaaacc ccttcataca 1096681 tcatcgaaaa gtcaccgcag aagccggtac aaaacacaac ccagaaagaa tcgctatttt 1096741 cctatcttga caagcatcaa acgcagttta agctcaaagg gaatgcgaac agccattttc 1096801 gcgtttcgaa aaccataaag gatccaaaga caaaacaaac gttttttaaa ttaacggagg 1096861 tttacaaagg aattccgatt tacggctttg aacaagcggt cgcgatgaag gaaaacaaac 1096921 aagtgaaaag tttctttgga aaggtgcatc cgcaaatcaa ggacgtctcc gtcacaccgt 1096981 ctatttctga gaaaaaagca atacatacag caaggcgtga gctcgaggct tccattggaa 1097041 aaatcgaata tcttgatggg gaaccaaaag gcgaattata tatctatcca cacgacggtg 1097101 aatatgatct cgcctacctt gtgagactct cgacatctga acctgagcct ggctattggc 1097161 attatttcat cgatgccaaa aacggaaagg tcatcgagtc ctttaatgcc attcatgaag 1097221 cggcaggtac aggaatcggc gtgtcaggtg atgaaaaaag ctttgacgtc acagaacaaa 1097281 atgggcgctt ttatttggct gacgaaacaa ggggaaaagg gatcaataca tttgacgcga 1097341 agaacctgaa cgaaaccttg tttacgcttt tgtctcaact gatcgggtat acgggcaaag 1097401 aaatagtcag cggcacgtcc gtatttaatg aacctgcggc tgtagacgca cacgcaaatg 1097461 cgcaagccgt ttacgattat tacagcaaga catttggccg tgattctttt gatcaaaacg 1097521 gagcaaggat tacgtctacc gtgcatgtcg gcaaacaatg gaacaatgct gcgtggaacg 1097581 gtgtccagat ggtatacggg gatggagacg gttcgaaatt taagccgctg tctggatcgc 1097641 tcgacattgt cgcgcatgaa atcacacacg cagtcacaca gtattccgcc ggtcttttat 1097701 atcaaggaga acccggtgca ttaaatgagt ccatttctga cattatgggc gcgatggctg 1097761 accgtgatga ttgggagatc ggcgaagatg tctatactcc tggtattgca ggagattcat 1097821 tgcggtcatt ggaggaccca tctaagcagg gaaatccaga tcattactcg aaccgctaca 1097881 caggaacaga ggattatggc ggagtccata tcaattcgtc cattcacaat aaagcagctt 1097941 atcttcttgc agaaggaggc gtgcaccacg gtgtacaggt tgaagggatt gggcgtgaag 1098001 caagtgaaca aatttactat cgggctttaa catattatgt aacggcatct acagatttca 1098061 gcatgatgaa gcaagcggcg attgaagctg ccaatgattt atacggtgaa ggctcgaagc 1098121 aatcagcttc agtcgaaaag gcgtatgagg ctgtcggcat tctatgagca aacaaaaaca 1098181 gtcaggacac agagtctgac tgtttttgtt tgctcatttt cttaaaaaga atatcgccaa 1098241 tgtacctgga ccggcatgcg agccgatggc tgaactgatt ggatgcataa tgatttcttt 1098301 cggcttgaac gcttcctcaa tcaggtgttt catatccgtg gctttttctt tgttcgcggc 1098361 gtagctaatc ccgacggttt gattgctcca atcatccccg cgctctttca taagctcgat 1098421 gatccgtttg aaaagtttct tctgtccgcg aattttttcc agaggcacaa gcttgccgtc 1098481 ctccatctga agcagcggtt taatattcaa caggccgccg acaaaagcgg acgttttgga 1098541 tatccggccg cccctcgcga gatatgttaa atcatcaacg gtaaaaatgt gttcaagctg 1098601 gctgcaaaag ttctttacag acgtttcaat ttcttgtatt gtattcccgt tgatacagag 1098661 atcggcagca tgccggacag ccagaccgta tcctaatgaa gcgcatttgg aatcaatgac 1098721 ccgcaaatcg aaatcgggga attcctcctt cacttcattg gcgatcatta cagctgtctg 1098781 atacgtgccg gagagacctg aggaaaaggc aatgtaaaga gcgggatcac ctgtttcggc 1098841 atattgcaaa aacacatttt taatcgtttg cggtgaggct tgggacgtct taggcgtttc 1098901 tccattttgc atcgcttcaa atatttgatc cgcatgaatt gtgactgcat cttcgaattc 1098961 tttatcgccg agagaaaccc tgagcggaat aaagccaatg cctttttctt caaaataaga 1099021 acgaggcaaa tcagtggcgc tgtcagcgat gagatgaact gtcatattgc ttcccttctt 1099081 tccgttatcg ctcgttatca tgagagttaa gccaactata tcatattaat ttgccaaaat 1099141 cgtgttcaaa tatttgtttt aagggaaaac ataataaaga agaaagagcg gaggaacatg 1099201 ccatggtact agatcaaaca aaaaaattac tcatcgtcat catcggcgct ttactcaatg 1099261 ctgccgggct gaacttattt ttgatacctg cagatgtata tgccagcgga tttacaggtg 1099321 ttgcccagct tttatcaagc gtcgttgatc aatatgcccc cttttacata tcgacgggaa 1099381 cgctcttgtt cctcttaaac attccggtcg gtattttagg atggctgaag gtcggcaaat 1099441 cgtttacagt gtacagcatt ttaagtgtcg cactcactac tctgtttatg gggatcctgc 1099501 cggaaacaag cctgtcacat gacattttgc tgaacgcggt gttcggcggc gtcatttccg 1099561 cagtcggtat cggcttaaca ttaaaatacg gagcttcgac aggcgggctt gatatcgtcg 1099621 ccatggtact tgcaaagtgg aaggataaac ccgtcggcac gtatttcttc attctgaacg 1099681 ggattatcat cttgacggca ggattattgc aaggttggga gaaagcatta tataccctgg 1099741 ttacactata tgtgacaacg agggtgatcg acgccattca cactcgccac atgaagctta 1099801 cggcaatgat tgtgacgaaa aaagcggacg aaatcaagga agccatttac ggaaaaatgg 1099861 tgcgcggcat cacaactgtt ccggcaaaag gagcatttac gaacgaacag aaagaaatga 1099921 tgattatcgt catcacgagg tatgaactgt acgatttaga aaagatcgtc aaagaagttg 1099981 atccaaaagc atttacgaac atcgttcaaa cgacagggat ttttggtttc tttagaaaag 1100041 actgacgaaa gcaggtggaa gtcgtgaaac ggctgcttgt gatgctcctc cccgtgctgc 1100101 ttttgatagg ctgcgggaaa gatgagcaga cagaacccga taaggaggta tcaggcggaa 1100161 tggagaatca agaggttgtt ttatctattg acgcaattca ggagcctgaa caaatcaagt 1100221 ttaacatgtc gctgaagaac caaagcgaac gtgctattga gtttcaattc agcacagggc 1100281 aaaaatttga acttgtcgtg tatgattctg agcacaaaga aagataccgt tattcgaaag 1100341 aaaaaatgtt tacgcaggct tttcaaaacc tgacgcttga atctggagaa acatatgatt 1100401 tctctgatgt gtggaaggaa gtccctgagc ccggaaccta tgaggtaaag gtgacattta 1100461 agggcagggc ggaaaatctc aagcaggttc aggctgttca gcagtttgaa gtcaaataag 1100521 aggctatggc gagtcgccat agcctttttt tattgcagtt tgtccagctg attttgaaat 1100581 tgatgcaact gttgacgttc cgcatctgtc gaattggcat acgcagaaga tacagcattt 1100641 ttggctctca gaatcgcttg ctcctgatcg ccttcctcaa agccgtttgt caccatgacc 1100701 gcctgttgaa caaatgattt tgcctgctga aacagttcat ttctcattta atattcatac 1100761 tgcctttcag ccgagtctcg tgccgcggca tgctggtgag cttcttctaa agtagaccga 1100821 tatggaaatc ttgcggcgtg tagcccgatg gagtctttac cctgctgaat aaaccttctg 1100881 gatttgcttc gtttacccat tttgagactg cccccttcca tactttgacg agatgagtcg 1100941 tcttcaatag tatggtgggg taaagtaagg tttatgagtg ggaaaaatta atacggacct 1101001 tctttaaagt gagaaatatt ctttcaaaaa ccttgccacg ccgtcctctt catttgtggc 1101061 cgtagttcgg ttggcaatct gcttgaccgc gtcaattcca tttcccattg caacgccgca 1101121 gcctgcaaat tcaagcattt ccaaatcgtt atcctcatct ccaaaagcaa tgatccgctc 1101181 cctcggcacg ccgtaataat cgctgatttt ctgcaggccg accgctttat tcatgccgct 1101241 tttgataatt tcaatgacat gccaaggagc ggcccatctt ctatggtcga tcacctcggc 1101301 atgcacatcc gataaatatg agcgtattgc cggcacatcc tcttcctttg catgtatgag 1101361 tacggacgtc acatcttcac cgagattttc ccgcaagtct ccgaccgtta catttgttgt 1101421 gttcatgtta aaggcatcta tcaggtgctc atcatggtaa tgaaagtata cgtcgtcaat 1101481 cacttcagca agcacgttat gtacgttgta gctctcgctg atatccacga gctgtttgac 1101541 aacatcaagc ggcagtgacg tatgataccg tccccagctg tcgtcttgcg gatgatggac 1101601 aaatgctccg ttaaaattga caattggcgt tgtcagctcc atctgctggt agtacatgga 1101661 acttgaacga tacggacggc ctgttgagat gcagacataa tgcccgtcat cttttaggcg 1101721 ctgtatcgta tgaagggtgt tttcagatat ggttttatca tcctttaata atgttccatc 1101781 taaatctaat gcgattaaat agggttttgt ctccatgaaa agctccttta accttagatt 1101841 ttgcttgttt tgccttactt acagtgtagc tttttaccat ctttattgtc tacatgttac 1101901 acttatgatt atggttatcc taaggagggg cacattgtga tacaaattga gaatcaaacc 1101961 gtttccggta ttccgttttt acatattgta aaggaagaga acaggcaccg cgctgttcct 1102021 ctcgtgatct ttatacatgg ttttacaagc gcgaaggaac acaaccttca tattgcttat 1102081 ctgcttgcgg agaagggttt tagagccgtt ctgccggagg ctttgcacca tggggaacgg 1102141 ggagaagaaa tggctgttga agagctggcg gggcattttt gggatatcgt cctcaacgag 1102201 attgaagaga tcggcgtact taaaaaccat tttgaaaaag agggcctgat agacggcggc 1102261 cgcatcggtc tcgcaggcac gtcaatgggc ggcatcacaa cgcttggcgc tttgactgca 1102321 tatgattgga taaaagccgg cgtcagcctg atgggaagcc cgaattacgt ggagctgttt 1102381 cagcagcaga ttgaccatat tcaatctcag ggcattgaaa tcgatgtgcc ggaagagaag 1102441 gtacagcagc tgatgaaacg tctcgagttg cgggatctca gccttcagcc ggagaaactg 1102501 caacagcgcc cgcttttatt ttggcacggc gcaaaagata aagttgtgcc ttacgcgccg 1102561 acccggaaat tttatgacac gattaaatcc cattacagcg agcagccgga acgcctgcaa 1102621 tttatcggag atgaaaacgc tgaccataaa gtcccgcggg cagctgtgtt aaaaacgatt 1102681 gaatggtttg aaacgtactt ataaagcact aagttattaa caagagctga atttacgtta 1102741 tactgtagaa aaaaggagtg agggaacgtg gaagaagcat taaaagaaaa catcatgggc 1102801 gccctggaac aggttgtcga tcctgagctt ggcgttgata tcgtgaacct cggcttggta 1102861 tatgacgttg atatggatga agatggcttg acgcacatca ccatgacgct aacatcaatg 1102921 ggatgccctt tagcgccgat tatcgtggat gaggtgaaaa aagcattagc ggaccttcct 1102981 gaagtgaaag acacagaggt tcacattgta tggaatccgc cttggactag ggataaaatg 1103041 tccagatacg caaaaattgc gcttggcatt caataaaaca aaaaaggaca gcctgacatg 1103101 tgaggctgtc cttttttaca gctgaaagga gtgaaaggaa atgatgtacc tgctggcagt 1103161 tttatgcccg ccgcttgctg ttttgttttc gggaaaaccg tttcaggcct tgctgaatct 1103221 catattgacc tgtatctttt ggctgccggg cgcgattcac gcctgcttta tcgtcgccga 1103281 ccgccgtgcc gaaaaacggg caagaagata atttggaaaa atgaggacgc agtcatggta 1103341 taatggtcat aaaaacagca gggagagcac tatgaaaaag aaattgcttg cattcgcgct 1103401 ttgtactggc gcgtatgcgg ccctgtttgc gtactctgtg aactcagagc aaaaaacagc 1103461 cacaagcgag atgacggatg tcagccgcct gatgcctgta aaaataaagc agacagtgaa 1103521 agggcaggaa gaggaaatgc tcattgacac agtcaaagag gcaaatcgaa aaaacataaa 1103581 aatttcaatc gccggggccc agcactccat gggcggccat acatattatg aggacggcat 1103641 cgttctcgac atgacgggct acaacaaaat cctgtcactc gatcaagaga agaaaaccat 1103701 cagggtgcaa agcggtgcaa cgtggaatga tatccagaaa tacgtgaatc catacggact 1103761 cgcggtaaaa gtcatgcagt cacaaaacat ttttacaatc ggcggatctc tcagcgcaaa 1103821 tgcacacgga cgtgatattc gctacggctc gctaattgat acagtcaaat cattccggct 1103881 tttaaaagct gacgggatga ttatcactgt cactccaaaa gatgatttgt ttacggcggt 1103941 catcggaggg tacggccttt ttggcgtgat tcttgatgta acgcttgagc tgacagatga 1104001 tgagctgtat gtcatgaaga cagaaaaaat gaattacagc acatactcag actatttttc 1104061 aaagcatgta aaaggaaatc cagatgtccg aatgcatctg gcgcgaattt caacagcgaa 1104121 aaaaggattt ctgaaagaca tgtatgtcac gaattacgta ttggctaatc atcaggatca 1104181 gctgtcctca tacagcgaac ttaaagaaga cgagtatacg ggagccacaa agtttgcact 1104241 cggcttgtca agacggtatg aatgggggag gaattggctg tgggacacac agcaatccta 1104301 tttcctgagc cagaacggca cagagatttc acgcaataac gtcatgcggt ccgaatcaaa 1104361 gtttcttgag tatgaaaaca atgacaacac agatgttttg caagaatact ttgtgcccgt 1104421 gaaggagtat gggtcctata ttgatgacct gagacaaacg ctgtcggacg aagatctgaa 1104481 cctgctgaac attacgatcc gctacgtgca gaaaaatgaa aaggccgacc tttcctatgc 1104541 gaaggacgat atgttttcgc tcgtactatt aataaacgag ggcttttcaa aagaagacca 1104601 ggcagatacc gcccgaatca tcaggcgcat gacagacgtt gccatcaagc acggcggcag 1104661 ctattatctg ccttatatga cctaccagac aaaagcgcaa atgagacagg catatccgaa 1104721 aagtgaagcg ttttttcaga aaaaacgaac ctatgacccg gatgagcgct ttatgaatta 1104781 cttttatcag aggtataaat aatggggaaa aacaaattaa aatggctgac attatcacaa 1104841 agcagcgtgt ttttcgcaag cagcttaatc tttccgtttt atattctgtt tgtgaaaaat 1104901 atcggctcaa gctacacaca gttcggtttt tcctacggat tgttcgggtt gagcggagcg 1104961 cttatttacc cgctcctcgg acggctgtct gaaaggtttg acagccgtta ttttctgctt 1105021 ctgaactcgt gggggatggc tgttctgctt ttatatgtcc cgcatatcgg aagcgtcgtt 1105081 caagtgtata tcgtccaagt gctgttaggg ctctttggag cgatgcaaaa gcatggagaa 1105141 aaagtgctga tcgctaattt tacagacagt ggagagcgtg gaaagaagat cgggaattac 1105201 catttttgga cagctgtctt ttcagcagca gccattatgc tcgggggctt tctcgctgac 1105261 tttttcacag tgcaaatgat tttttatgca agctctattc tatatttttt gagtggattg 1105321 atgatgatga aaacaggctg acgcggtcag cctgtttttt tatgcggctg aaatgcggca 1105381 ccgcatcaac gtttttgtgc tggagtcgtg ctgatttttt ttgagcggaa ttcccattga 1105441 acagaaaatt tataaatgaa taaaaatatt aaatatacga ttgaattaat ttttattcat 1105501 gttataatgt taaataattt cacaaagacc aagagggtga acttgttttg aaaataggaa 1105561 ttgtaggtgc tacaggatat ggaggcaccg aacttgtcag gattctttcg catcatcctc 1105621 atgcagagga atgcatactt tattcatcca gcggagaagg gaatgtctat agcgagggtt 1105681 atcctcatct taccggctta gcggatcagc agctgaagcc gattgatatg aatacgatca 1105741 aacacgaaat agatatcatg tttctcgctg cgccgcccgg agtatcaagt gaattgactc 1105801 caaagctggc agacgcggga attacggtta ttgatctgtc aggtgatctg aggataaaag 1105861 aaccggctga atatgaaaaa tggtataaac ggacagcggc accgaaggcg gtgattcaag 1105921 aggcggtata cggtctggca gaactgaatc aactgcaaat tcaacaggcg aaactcattg 1105981 ccaatccagg ctgttttcca acagctgttt tgcttggcct cgcgccattg gctcaaaaga 1106041 aactgctcga tgaatctttc gttatcgttg acgcgaagac cggtgtttcc ggagcgggaa 1106101 gaaaagcatc catgggaact catttttctg agctgaacga caattttaaa atttataaag 1106161 tcaatgaaca tcagcacacg ccggaaattg agcaggcgct gaatgaatgg cagccaggtc 1106221 tcgggcccat tacattttcg gctcacttgg ttccgatgac aaggggcatc atggcgacga 1106281 tgtataccag attaacctgt gacctaaccg cagatgacct gcatgattta tattcggaat 1106341 tttaccaaga ttcatatttt gtgagagtga ggccaaaagg tcagtacccg caaacgaaag 1106401 aagtgtacgg cagcaatttc tgtgatatcg ccgtgaccct cgatgagaga acgaacagag 1106461 tcacgatcgt ctcggtaatc gataatttaa tgaagggtgc cgccggtcag gcagtgcaaa 1106521 actttaattt gatgaatggc tggaatgaag aaactggact caccatcacg ccaatttatc 1106581 catagaacgg gagagaatcg aaccatgatt cagttaagtg aagatcaaat tgtaaaagta 1106641 acaggtgatg tatcctcgcc aaaagggttt caggcaaagg gtgtgcattg cggactgcgc 1106701 tactcgaaaa aagacctcgg cgtcattatc agcgagacac cggccgtgag tgcagcagtt 1106761 tatacccaaa gccactttca ggctgctccg atcaaagtga cacaagacag cttaaagcac 1106821 ggaccgacac tgaaagccgt catcgtcaac agcgccattg ccaacgcctg cacgggagaa 1106881 cagggcttaa aggacgcata cacaatgcgg gagagctttg cttcacagct tggcattgag 1106941 ccggagcttg tcgctgtttc atcaacgggt gtcatcggcg agcatttaga catggaaaaa 1107001 atccacgcgg ggatcgaact gctgaaagaa acacctgcgg gatcaggcga ttttgaggaa 1107061 gcgattttaa caactgatac ggtgatcaag cagacgtgct atgaactggc aatcggcggc 1107121 aaaacagtca cgatcggcgg agcggccaaa ggctctggga tgatacaccc gaacatggcc 1107181 acgatgctgg gatttgtgac aactgacgcg gcaatcgaag aaaaagcgct gcaaaaggcg 1107241 cttcgggaaa tcactgacgt ttcatttaac caaatcacag ttgacggaga aacatccacg 1107301 aacgacatgg tattagttat ggcgaatggc tgcgccgaaa acgagtgcct gacagaagac 1107361 catccagact ggccggtctt taaaaaagcg ctcttgctca cttgtgagga tctagctaaa 1107421 gagattgcca gagacggaga aggcgcgaca aaactaattg aagcccaagt acagggagcg 1107481 aaaaacaatc ttgatgcaaa cgtcattgcc aaaaagattg tcggctcaaa tcttgtaaaa 1107541 acggcagtat acggaacaga tgccaactgg gggcggatca tcggagccat cggacactcc 1107601 gcagcacagg tgacggcaga agaagtagag gtttatcttg gcggccaatg cctgtttaag 1107661 aataacgaac ctcagccatt ctctgaatct atcgccaagg aataccttga aggagatgaa 1107721 atcaccattg tcatcaagat ggctgaaggg gacggaaacg ggagagcgtg gggctgtgac 1107781 ctgacctatg actatatcaa aattaacgcg agctatcgca cgtaataaag gggagcgaaa 1107841 tgaagaaaac aatcgttttt aaatgcgggg gaagcgtcat ccgtgagctg tcggaggaat 1107901 tttatcaaaa tctgaaagag ctgagggcgt caggctggaa gctggcaatc gtacatggcg 1107961 ggggaccgga aatcacaaat atgctgaaac ggttaaatat caagacagag ttttcgggcg 1108021 gacagaggaa aacaacgaag ccggtgctgg aagtggcgga aatggtttta tccggttctg 1108081 tcaataaatt tttcgttgct gagcttgcca aacacggact gcgagccgcg ggcatttctg 1108141 gtaaggatgg cggtcttttg gaggctgatt atctagatcc ggaaacatac ggagaagtgg 1108201 gagaaatcaa aaaagtcgat gcgtccatgg tgaacgcgct gatggaaaat ggcatcatcc 1108261 ccgttattgc gccgctgtct atgacaagcg actgcaaaac gctgaatgta aatgctgatc 1108321 tggctgcttc agcagtcgcc ggagcgcttg aagccgataa gctgatgttc gtcacggatg 1108381 tcgatggaat catgaaggaa aagcagcgtc tggacgtcct gacccctaag gagattcaga 1108441 tgctgatcaa gcaggaagtg atcacaggag ggatgatccc gaaggtcaat tcagccttgt 1108501 cagctttatc agatcaggtg tctgaagtca tgatcgtaaa cggtaaagga tcattcttcg 1108561 cagaacaaac ctttcaaggg acaaaaattg tcaaagcaaa ggaggctgtt tcatgagcag 1108621 cttgtttcaa acctacggcc gttgggatat tgacatcaaa aaagcaaagg gaacgtacgt 1108681 tgaggatcaa aacggcaaaa cgtaccttga tttcattcag gggattgcgg tatcaaatct 1108741 aggacactgc catgaagcgg tgacagaggc agtcaaaaaa cagcttgaca gcgtatggca 1108801 cgtatccaac ctgtttcaaa acagtctcca agagcaagcg gcgcagaagc tggcagcgca 1108861 tagtgcggga gatcttgtct ttttctgcaa cagcggcgcg gaggcgaatg aaggtgcgat 1108921 aaagcttgcc agaaaagcaa ctggaaaaac aaaaatcatc acttttcttc agtcgttcca 1108981 tggccgcacg tatgcaggga tggctgcgac cggacaggat aaaatcaaaa caggcttcgg 1109041 cccgatgctt ggaggctttc actacctgcc atacaatgat ccttctgctt ttaaagctct 1109101 tggggaggaa ggcgatattg ccgcggtgat gcttgaaaca gtgcagggag aaggaggagt 1109161 caatccggcg agtgctgaat ttttatcagc cgtacagtcg ttttgcaagg aaaagcaagc 1109221 ccttctcatt attgatgaaa tccagaccgg catcggacgg acgggaaaag gcttcgcata 1109281 tgagcacttc ggactctcac cggatatcat cacagtcgcc aaaggattgg gaaacggctt 1109341 tccggtcggc gctgtcatcg gaaagaaaca gcttggagaa gcgtttaccc ctggttctca 1109401 cggaacgact ttcggaggaa acatgctggc gatggctgct gtgaatgcca cattgcaaat 1109461 tgtattccag cctgactttt tgcaagaggc tgctgacaaa ggggcgtttt taaaagaaca 1109521 gcttgaggca gagctaaaga gcccttttgt taaacaaatc cgaggtaaag gattaatgct 1109581 tggaattgag tgtgatggcc cggttgctga cattattgct gaattgcaga cattaggctt 1109641 gcttgtattg ccggccggcc cgaacgtgat tcggctgctg ccgccgctca ccgtgactaa 1109701 ggatgaaata gcagaagccg tcagcaagct gaaacaggca atcgctcatc attccgctgt 1109761 aaaccagtga ttttttttcg atataaaggc ataaaaattc atttttataa ttaattattc 1109821 atcaagaggt gggctgttag atggaaggtt atttagtgtt agaagatggg acatcgttca 1109881 gcggcgagct ggacggtcat gaaaactgca cgggagaagc tgtttttttc acaggaatga 1109941 caggctacca ggaagtgctg acagatccat catataaggg acagattatt gtatttacct 1110001 acccgctgat tggcaactac ggcataaatg aaaaggattt tgaaagcaag aaaccgcaag 1110061 taaaagccgc ggttgtctat gaggcgtgtg atcacttttc tcattatgaa gcggtataca 1110121 gcctcaagga gtatctacag aaatggaata ttccgctgtt aacccatgtt gatacgaggg 1110181 ctgtcgtgaa gaaaatccgg gcaaacggga cgatgggtgc gacagtcaca gcctctaaag 1110241 aaggagctga gattgccctt caaccagaga atgtggcaga gcaggcttcc gcccaggaaa 1110301 tcagcacatt cggcgacggg aataaacata tcgctctcat tgattttggc tataaaaagt 1110361 caatcgcatc atcacttgtc aaacgaggct gcaaggttac cgtggtgcca taccagcaaa 1110421 tggaggccgt atacaacatc aaacccgatg ggctatcgaa cggacctgga gatccgaaag 1110481 ccattcagcc atatttagga aagatcaaaa gcatcatcag ccgctttccg actctaggca 1110541 tttgtctcgg acatcagctg atcgcgctcg cgtttggagg gaatactttt aagctgccat 1110601 tcgggcacag gggagctaat catccggtca tcgaccgtaa gacgaaacgg gtctttatga 1110661 caagccaaaa ccacagctat gtggttgatg aacagtcgat taatgaagaa gagctcacca 1110721 tcaggtttca tcatgtcaat gatacgtcag ttgaagggct tgcccataaa aaactgcctg 1110781 tcatgagtgt tcaattccac ccggaagccc atcccggacc tgcggaaagc gaatggattt 1110841 ttgatgatta tctaaagaat gtgataccag caaggagaga aatcgcgcat gcctaaagac 1110901 accagtattt caagcatatt agtaattggc tcaggcccga tcatcatcgg gcaggcggca 1110961 gaatttgatt attcaggcac tcaagggtgc atcgcgctga aggaggaggg ctaccgggta 1111021 attctcgtca acagcaatcc ggcgacaatt atgactgatg aagccttcgc tgatgaaatt 1111081 tattttgagc ctctgacagc agaaagcctg acagccatca ttaagaaaga acggcctgat 1111141 gggcttcttg ccaatttagg cggtcagacc gcgttgaatt tagcggtgga gcttgaagaa 1111201 acgggtgttt taaaagagca cggcgtcaaa ctcctcggca catccgttga aacgatacaa 1111261 aaaggagagg accgggaaaa attccgttcg ttaatgaatg aattaaaaca gcctgtgccg 1111321 gagagtgaaa ttgttgataa cgaggccgat gccctccatt ttgcggaatc catcggtttt 1111381 cctgttatta tcagaccagc ttacacatta ggcggaaagg gcggaggaat cgcccctgat 1111441 aaagaagcct ttacagctat gattaagcag gcgctattag caagcccgat caatcaatgc 1111501 cttgtcgaaa aaagcattgc cggctttaaa gaaattgaat atgaagtcat gcgtgacagc 1111561 aataacacat gcattaccgt ctgcaatatg gaaaatatcg atccggtcgg cgtgcataca 1111621 ggtgactcta tcgttgtggc gccgtcacaa acattgacag acgaagacta tcaaatgctg 1111681 cggacagcaa gtctgacgat catctcagca cttgatgttg taggcggctg caacattcaa 1111741 ttcgcgcttg atccattcag caagcaatat tacgtcattg aagtgaatcc gcgtgtaagc 1111801 cggtcatcgg ctctcgcatc taaagcgacc ggttatccga ttgcgaagat ggccgcgaaa 1111861 ctggcagtcg gatacactct tgacgagctg aaaaatccgc tcacaggctc gacttacgca 1111921 agctttgaac cggcactgga ttatgtgatc gtcaaatttc cgcgctggcc gtttgataaa 1111981 ttcaaaaacg cagaccgcaa gcttggcaca aaaatgaaag ccaccggtga agtgatggcg 1112041 attgaacgga atttagaagc ggcgatacaa aaggcagccg cgtcgcttga attaaaaaat 1112101 atcgggacac accttccaga gctcagcggg ttgtcaattg atacgctatg ggatttggca 1112161 atcactccgg atgaccgcag atttttcgtt gtcatggagc tgttgagccg cagcgtctcg 1112221 attgatgaca tccatgaaaa aacaaaaatt gatccgtttt tccttcatac ctttgacaac 1112281 atcatcaaat tggaaaaccg cctgatggaa gcagggagcg atctctcttt tgaattattg 1112341 aagaaagcaa aggaaaaggg attctcagac gcaacgattg cctcgctgat cagcaaaaca 1112401 gaagaagagg tgcgcgcgct tcgcaaggag atgggcatta cgccttcctt taaaatcgta 1112461 gatacatgcg cggcagagtt tgatgcgaaa acaaactatt tttactccac atatttcgga 1112521 gagaccgatg gagacatcag ccgcaaagag aaaaaacgcg cgctcattat cggatcaggc 1112581 ccgattcgga tcggccaagg cgttgaattt gattacagtg ctgttcacgg tgtgctgaca 1112641 ctgcaagagc ttgggttcga aaccatcatg attaacaata acccggaaac tgtcagcacc 1112701 gattatgaaa ttgcggaccg cctgtatttt gaaccgatga caacggagca tattgtaaac 1112761 gtggcggagc aggaaaatat tgattttgca attgtgcaat ttggcggtca aactgcaatc 1112821 aatgctgctg aagcgctcga aaaagccggc attactcttc ttggcacatc atttcaaacg 1112881 ctcgacgtgt tagaggatcg ggatcaattt tatcagcttc ttgacgagct gggattgaag 1112941 cacgcaaaag gagaaattgc ttatacaaaa gaagaagccg cttcaaaagc gagtgagatc 1113001 ggctatccgg tgttaatccg cccatcttac gttatcggcg gaatgggcat gatcattgtt 1113061 gactcgcaag cccagctttc tcagctgctg aatgatgagg acagcatgcc atacccgatt 1113121 ttaattgatc agtatgtgtc tggaaaggaa gtcgaaattg atttgatttc cgacggcgag 1113181 gaagtcttta tcccgacata taccgagcat attgaacggg caggtgtcca ttcaggggac 1113241 agttttgcca ttcttcccgg accgtccatc acgagcgggc tgcagcaggg catgaaagat 1113301 gcggcacaaa aaattgcccg aaaactttca tttaaaggca tcatgaacat tcaatttgtg 1113361 atcgacaatg gaaacatact cgttcttgaa gtgaatccga gagcgagccg cacggttcct 1113421 gtcgtcagca aagtaatggg cgttccgatg attccgctcg ccacacgtct gctggcggga 1113481 gcgtccttaa aagatctaaa tccggcagtt caaaatcatc atggagttgc cgtgaagttc 1113541 cctgtttttt cttctcatgc gatccaggat gtggatgtca agcttggacc ggaaatgaaa 1113601 tcaacgggag aaggcatgtg tgtcgcatat gattctaaca gcgccttgaa aaaaatctat 1113661 acaagagtct ggagtcaaaa aggaagcatt tatttgcaaa acgttccgga agatgtgaag 1113721 gagttagcag aaaacgcagg ttttacaata catgaaggaa catttgcctc atggatggaa 1113781 caggaaggaa actcgctcca cattaatctg agcggttctg aagaagcacg caaagaacgt 1113841 ttggaagcca tgacgcacgg catccccgtc tttacagaag aagaaactgt gcgggcgttt 1113901 ttacaaagcg gttcaggcca tccgcagcct gtatctctca aagacctcta taaaaaggaa 1113961 gtggcatcat gcacacagtg acgcaaacca gtttatacgg aaaagattta ttaacgttaa 1114021 aggaccttag tgaagaagat ataaacgcct tgctcgcaga agccggtgag ctgaaacaaa 1114081 acaaaattca gcctatattc catggcaaaa ccttggcgat gatttttgaa aaatcatcaa 1114141 cgcggacccg tgtttcattt gaagcgggca tggcgcagct gggcgggagc gccctctttc 1114201 taagccagaa agatctgcag ctggggcgcg gtgagactgt cgctgatacg gcaaaagtgc 1114261 tgtcaggcta tgtggatgcc atcatgatcc ggacctttga acatgaaaag gtggaggaac 1114321 ttgccaaaga agctgacatt ccggtgatca atggacttac cgataaatac cacccatgcc 1114381 aggcgctggc ggatctcttg acgattaagg agataaaagg gaagcttaaa ggcgtaaaag 1114441 tcgcgtacat cggtgacgga aataacgtgg cgcactcctt gatgatcggc tgcgcgaaaa 1114501 tgggctgtga tatctcgatc gcttcaccaa agggatatga agtgttagat gaagcagctg 1114561 aagcggcaaa gacatatgca cttcaatccg gctcttctgt cacgctgaca gatgatccga 1114621 ttgaagctgt aaaagacgcg gacgtgattt attctgatgt gtttacaagc atggggcagg 1114681 aagcggaaga gcaagaacgt cttgctgtct ttgcgcctta tcaggtgaat gcggcgctgg 1114741 tcagccatgc caagcctgac tatacatttt tacattgtct ccctgcgcat cgcgaggaag 1114801 aagtgactgc ggagattatt gacgggccga actctgcagt gttccagcag gcggaaaacc 1114861 gtcttcatgt gcaaaaagca ctgctgaagg ccattttata taaaggggaa tcatcaaaaa 1114921 actgctgagc caaactcagc agtttttttg atggcaacat attcacagcc gcttaggcgc 1114981 atactacagc aaaaaggaaa aggaggaaaa acagtgggac agcagcacca attccggccc 1115041 ggacagaaag cgcctaataa cggtgtctac gtagaaatcg gcgagacagg gagcatggtt 1115101 aaaaaccctc aaaaggtcca tctgtcagca ggggaaatgt tccccgaaac atcaaaccac 1115161 aaccggctgt ggacctacaa aagaaagccg tgaccactaa aaaacccaaa acaataaatg 1115221 ttttgggttt ttggcttttt aatgctggct tgcatttttg ttcataggca tgatttctgc 1115281 taaaaccatg attaagacat acagtacaac agcaatgaca gatgatgttt tgaaattata 1115341 cgtaacgctg ttcatgcttg caaccaagta gcatgccata tgtgataaaa ggaacgtcca 1115401 aataaaggca ataatatatc gcacgtttcc acctcgtcct tctcattcta ttctaaaagt 1115461 tatcatacca tacaaaaagc gaagggggaa tccaatttta gcagaaagtg aggtgacaaa 1115521 agagtctgat tcgtcacact ttaatggtaa aatataaaac gtcaatcagt ataatagcca 1115581 aaaatgtaaa aggctaggac tttaccttat tcgtttcttt tctatttaca taagatagcg 1115641 tgagatgaag tgtgaaagga ggcgggcaag cgatgggaat aacggaaaga tactttcaac 1115701 tgggaacgga gcataatgtc attcatctgc cctatcgccc gaacggcttc ggcatcttta 1115761 tcttggggga cagaacccac tttgtcggac atgattcaag cttttggcag cagcattatg 1115821 gcagaaatca gcttctgagc atgttgatga atgaaggata cactcttttt aacagcaatc 1115881 tgttcggaag gcattggggg gcggaaaaag cagtcaccta tgccaaacag ctgatacatt 1115941 ctgtgctgaa gcaggaaatc ctcaatccga agattcatat tttagcagaa ggcatgggtg 1116001 ctctcgtggc cgatgaactg cttcgttttt ccccggatca tatccgctca gccgcaatgt 1116061 tgaatccttg tctcgatctt caggcacatt atgaatcgga aaaagaaaat aaatttttct 1116121 ataagcaatt tttgaaagaa gtatcgaaaa gctacggaat ttctgaaaaa gaagcggaag 1116181 cgattcgtta taaaacaatt caaagctacc cgagcggcgt accggttcat atatggcagc 1116241 gtatgaccgg agctccatat ccctacagcg tacatgcgga agttttcaag gaaaaacagc 1116301 aaaagcaagg ctcaccggtc gacatgacat ttcatttatt tgagcatcca agcagaattt 1116361 atgcatcaat ttgcaaattc tttcatagtc atgaaaaaga attatagaga atataatgac 1116421 aacagccttc tcttttgcgg aggctgtttt gttttgggaa atgaaaaacc ggaagggcgg 1116481 cagatgcaat ggaatcaacg ctgattgtag gtgcggacga atttttcggc ctttcattat 1116541 gtgagcgaat gatggatgaa ggcatacatg ttgacgttgt tctggcggaa acagaagata 1116601 aaatgagaca aatgtactta gaagaaagac tcatgtggct tgggagaaat gaactctttc 1116661 gccagcttga acacattgga gaccaaaatt atgatacaat ttgtatccag ttcggaagtt 1116721 ttttgccttt agaccaatat gattctcctt atattttagt atatgaagaa gaccgaaaag 1116781 aatgggataa acgtgaaaaa acaggctcgg aaaaaaccgt gatcctgccg aaaatgtacg 1116841 ggccatggaa agaagaaaca gaggaagacg gctattacac aaacgacgtg gctgacgagt 1116901 tgctgagatt cctgttagaa ccaagccgtc atagcaaaga tcagcttttt gaattgcaag 1116961 tcacagagaa aacctcaaaa gaagaagcaa aaacaaaaat tatcgagtgg aaaagacaat 1117021 tttcatcaat tttcgacaaa tattaagaaa aaccttccat gtttcgagtt ttctagatac 1117081 aataaacgta taaaaataat acatgttata gcttgtcaaa aggagttgaa catgacttga 1117141 tcacaaggct tgtcatgatc ttttctgtcc tccttttatt gagtggatgt ggacaaactc 1117201 cgttcaaagg aaaaattgag aaggtcggca tgctctttcc tgatacgatt aatgacctcg 1117261 tatggggcac aaaagggtat aaaggattac tgaatataca atccaaatac aatgtggacg 1117321 tctattataa agaaggcgtt aaaacagaag aagatatcat aaatgcgatt gaggattttc 1117381 ataagagggg cgtcaatctg ctctacggcc atgggagtga atatgctgag gtgtttaact 1117441 tggtcggcga agattatcca gatatggaat tcgtcatttc caatgcgaaa gcgaaagctg 1117501 ataatgtaac aagtgtccat tttagcgggg aagcaatggg cttttttgga ggaatgactg 1117561 ctgcccatat gtcgaaaacg aatcaggtcg gtgtaattgc ttcctttacg tggcagcctg 1117621 aggttgacgg ttttatcaaa ggggccaagt atgaaaatcc ggatatagag gtaaatacga 1117681 aatatacgga tcattgggat gatgatacaa cagcagtaaa gctttatcag aaaatgaaga 1117741 acgaaggcgc ggatgttgtg tatcccgccg gagacgggta taatgttcct gttattcagc 1117801 aaatcaaaaa agacggtctt tatgccatag gctacgtcac agatcaatcg gatctgggcg 1117861 agaataccgt attaaccagc acggtgcaaa atgtggacaa ggcctatgaa atcattgctg 1117921 aacaatttaa taaaggcacc cttgagggcg gcgatcatta ctacgacctg aacacgggag 1117981 tcgttgagat gggaacattc agcccgctcg tcgatcaaga ctttcagcaa agaatcgcca 1118041 agctgatcaa aacatacaac aaaacaggcg agctgccaaa aaacgagtaa tggagtgacg 1118101 tcacatgcag cacgaaaaat cacttgaatt cttgcaaatt gccatgaaat atctccctga 1118161 agcgaaagaa cagcttgaga aatcaggcat tgagctctca atggaggcca tccagccgtt 1118221 tatgaatcta tttacaacgg taatggcgga agcttatgag cttggcaagt ctgacgctaa 1118281 atctgaaaca gaataagaag aagccacttt tttgaaagtg gcttttcaca tgattttctt 1118341 tttaatagcg gagagcatgg gcgcaagctc ctttaaagcg ggcttgattt gatcaagaga 1118401 gttcataatt gaaccgattt ggtccataat atgcatgtaa ttaatcgtct cttcgtcgtt 1118461 tgtctgagaa acctgagaaa cttcctcttg ctgttcctcc tccttctctt ctgttggttt 1118521 tgctgcatcg ccgaacatca ttcttgaaaa cacatccaac tgcatacgcc tcctttccat 1118581 ataccatact ctatgagtaa gatgaactga tagtttagac gaatatattg ccatgtgaaa 1118641 aaaaatagga tagaattagt acctgatact aataattgat cacaacctga ttgatcttct 1118701 aaatttaaga tataaaggag tcttccctaa tgaaagctgg aatacttggt gttggacgtt 1118761 acattcctga gaaggtttta acaaatcatg atcttgaaaa aatggttgaa acttctgacg 1118821 agtggattcg tacaagaaca ggaatagaag aaagaagaat cgcagcagat gatgtgtttt 1118881 catcacatat ggctgttgca gcagcgaaaa atgcgctgga acaagctgaa gtggctgctg 1118941 aggatctgga tatgatcttg gttgcaactg ttacacctga tcagtcattc cctacggtct 1119001 cttgtatgat tcaagaacaa ctcggcgcga agaaagcgtg tgctatggat atcagcgcgg 1119061 cttgtgcggg cttcatgtac ggggttgtaa ccggtaaaca atttattgaa tccggaacct 1119121 acaagcatgt tctagttgtt ggtgtagaga agctctcaag cattaccgac tgggaagacc 1119181 gcaatacagc cgttctgttt ggagacggag caggcgctgc ggtagtcggg ccagtcagtg 1119241 atgacagagg aatcctttca tttgaactag gagccgacgg cacaggcggt cagcacttgt 1119301 atctgaatga aaaacgacat acaatcatga atggacgaga agttttcaaa tttgcagtcc 1119361 gccaaatggg agaatcatgc gtaaatgtca ttgaaaaagc cggactttca aaagaggatg 1119421 tcgacttttt gattccgcat caggcgaaca tccgtatcat ggaagctgct cgcgagcgtt 1119481 tagagcttcc tgtcgaaaag atgtctaaaa ctgttcataa atatggaaat acttctgccg 1119541 catccattcc gatctctctt gtagaagaat tggaagccgg taaaatcaaa gacggcgatg 1119601 tggtcgttat ggtagggttc ggcggaggac taacatgggg cgccattgca atccgctggg 1119661 gccgataaaa aaaggtgagg tgcacacaag atgactaaaa aaagagtagt tgttacagga 1119721 cttggagcat tatctccact tggcaacgac gtcgatacaa gttggaataa cgcaatcaac 1119781 ggtgtgtccg gaatcggtcc gatcactcgt gttgacgctg aagaatatcc ggcaaaagtt 1119841 gccgctgaat taaaagattt taatgttgaa gattatatgg ataaaaaaga agccagaaaa 1119901 atggaccgct ttacacaata tgcggttgtg gctgcgaaaa tggcggttga agatgcagat 1119961 cttaacatta ccgatgagat cgcgccgaga gtcggtgttt gggtaggctc cggtatcgga 1120021 ggacttgaaa cactagagtc tcaatttgaa atcttcttaa caaaaggccc aagacgggta 1120081 agcccgtttt tcgtgccaat gatgattcct gacatggcga caggccagat ttctattgca 1120141 ttaggagcaa aaggggtgaa ctcttgtacg gttacagcat gtgctacagg aacgaactcc 1120201 atcggtgacg cgtttaaggt tattcagcgc ggtgatgcag acgtgatggt cacaggcgga 1120261 acagaagcgc cgctgacaag aatgtcattc gccggcttta gtgccaacaa agcgctgtct 1120321 actaatccag atccgaaaac agcgagccgc ccgtttgata aaaaccgtga tggctttgtc 1120381 atgggggaag gtgcagggat tatcgttctt gaagaacttg agcatgccct ggcccgcggc 1120441 gctaaaattt acggagaaat tgtcggctac ggctcaaccg gagacgctta tcatatcaca 1120501 gcgccggccc aagacggtga aggcggagcg agagcgatgc aagaagccat taaagatgca 1120561 ggcattgcac ctgaagaaat tgattacatc aatgctcacg ggacaagcac gtattacaac 1120621 gacaaatacg aaacaatggc gattaagacc gtttttggcg agcatgcgca taaacttgcg 1120681 gtaagctcta caaaatcgat gacaggccac ctcttaggag cagccggcgg tattgaagcc 1120741 attttctcta tcctggccat taaagaaggc gtgattccgc cgacaatcaa tattcaaaca 1120801 cctgacgaag aatgtgattt ggattatgtg cctgatgaag cccgcagaca ggaacttaat 1120861 tatgttctca gcaactcatt aggattcggc ggacacaacg caacattaat ctttaaaaaa 1120921 tatcaatcat aatcaagcca aaccggctgc ccttaaaggg tagccggttt tttttgtgtg 1120981 cataggatta aaagaggagg cgatcacatg agtgtagaac aaacatatag ctggctcagg 1121041 aaggccggtt caatagatga tttggcgcat tacattatcc cgcttttttc aggtgcggag 1121101 aaaaagaact ggaagggcat tctggggcat cttcagcatc atgggatgtt taaaaacata 1121161 aaagagggta ttcagacggt ttccaagctg aaggaaaaag gtttttacgg acatatccaa 1121221 aaggaagaac agtacctcaa aaacaaatgg caaggtcctg atgtaccaat tgttacgctg 1121281 ccggttgatg aacgaaacag gagaatccgt ttagaattcg gatcaaaatc aggactcgcc 1121341 tttcaagaca aaatgttcct ttttctttcg tcagatttag attttgggtc ggtatctgcc 1121401 cttatgacgc atgagtatca tcacgtttgc cggttaggtc atctgacaaa agaggaaaag 1121461 gatgtcacat tacttgatac aatcatcatg gaagggctgg cggaatatgc tgtttatgag 1121521 aggttcggcc gaagtcaaac ggctgaatgg acgacttggt atacaccgga acagcttcag 1121581 gctttatatg aaaaaaagat tgcgccccat cgggatatca aacgggataa tcgattattt 1121641 ccccagctgt tattcggcaa aggatatcag ccaaaaatgc ttggatacgc agttggattc 1121701 aatattgtaa aaaaatattt aaccgccagc aaggcaagca ccgcagacgg gctgtccatt 1121761 cctgctgaga cctttttgga tgcaatgctt taaaaggata aaataatgga atttcattaa 1121821 taatattaca tttatcctaa aaaattcttg attttgcaaa atgattgtaa taatatacaa 1121881 ctataaaatt tttcgataat tcaatattat ttattatttc tgaataaagg gattgctttc 1121941 tcttgaaaac gtttgacaac aagagggggg aaaggggagc tagcatgagc acacttttag 1122001 aagtgaataa tttaaagact tattttttca ggaaaaagga gccgatccct gcggttgacg 1122061 gagtcgattt tcacatcagc aaaggcgaaa ccgtcgcgct tgtaggtgaa tcgggctccg 1122121 gaaaaagcat tacttcttta tcaattatgg gcctcgtcca aagctcaggc ggaaaaatca 1122181 tggacggctc tattaaactc gaagacaaag acctcacctc attcactgaa aacgattatt 1122241 gcaaaatccg cggtaacgaa gtatccatga tctttcagga accaatgacc tcccttaatc 1122301 cggtgttaac aatcggagaa caaattaccg aagtgctgat ttaccataaa aacatgaaga 1122361 aaaaagaagc ccgtcaacga gctgttgaac tcttgcagat ggtcggtttc tcccgggcgg 1122421 agcaaattat gaaggagtac ccgcatcggc tgtccggcgg tatgagacag agggtgatga 1122481 ttgccatcgc actgagctgt aatcctaaac tgctcattgc tgatgaacca acgacagcgc 1122541 tggacgtgac aatacaagcc caggtgctgg agctcatgaa agatctctgt cagaagttca 1122601 atacatcgat tcttctcatc acacacgact taggtgtcgt gtctgaagct gccgatagag 1122661 tgattgtcat gtactgcgga caagtcgtag aaaacgccac tgttgatgac ttatttttag 1122721 aaccgcttca tccgtataca gaaggcctgc ttacgtcaat tcctgttata gatggagaga 1122781 ttgataaatt aaatgcgatt aaaggcagtg tgcctacacc ggataatctg ccgccggggt 1122841 gccgttttgc cccaaggtgc ccgaaagcta tggataagtg ctggacaaat cagccttcgc 1122901 ttttgacaca caaaagcgga agaacggtga gatgcttttt atatgaggaa gagggtgccg 1122961 aacaatcatg acagcagcta atcaagaaac aatcttagag cttcgtgacg taaaaaaata 1123021 ctttccgatc cggtcaggcc tttttcaaag aaaagtcggt gatgtaaaag cggtggatgg 1123081 tgtttcattt tcgttaaaaa aaggagaaac actcggaatc gttggagagt cgggctgcgg 1123141 aaaatcgact gccggcagaa cgatgatcag actgtacaaa ccgacagagg gccaaattct 1123201 ttttaaaggg caggatattt ccaatctgtc agaggagaag ctgcggaaga gtgtccgcaa 1123261 aaatattcaa atggttttcc aagatccatt tgcttcgtta aacccgagaa agaccctgcg 1123321 ttccatcata aaggagccgt ttaatacgca caacatgtat accatgcgtg aacgaaacga 1123381 aaaagttgaa gagctgcttg caagagtagg gcttcacccg tcgtttgccg gccgttatcc 1123441 ccatgagttt tcaggcggcc agcgtcagcg gatcggcatt gccagagcac tcactttgaa 1123501 tccagagctg atcattgcag atgagccggt ttccgcactt gatgtatcca ttcaggccca 1123561 agtgattaac ttgatggagg aattacagga agaatttaat cttacgtatc tatttatctc 1123621 tcatgatctg agtgtcgtcc gccatatcag cgacagagtc ggagtaatgt atcttggcaa 1123681 aatgatggaa ctgaccggca agcatgagct ttatgacaac ccgcttcacc catataccca 1123741 agcgctttta tcctccgttc cggttacaag aaaaagaggt tctgtcaaac gtgaacgcat 1123801 tgtcctgaag ggagaactgc ctagtccggc caacccgcca aaaggctgcg tattccacac 1123861 aagatgtcct gttgcaaaac cgatatgcaa ggaacaaata ccagaattta aagaagctgc 1123921 tcccagccac tttgtggctt gtcaccttta tagctaatgt tgcccgcaca gctttgagag 1123981 ggggtatgca cactacataa acaacagcct agaagaacga acatttcaag agggggaata 1124041 tctaatgaaa agacggaaaa ccgcactgat gatgctaagt gtattgatgg ttctggccat 1124101 ctttttatca gcctgctcgg gatcaaaatc aagcaacagc agcgcgaaaa aatcagcagg 1124161 caaaccgcag caaggcgggg atttggttgt tggttcaatc ggagaaccca cactttttaa 1124221 ctctctgtat tctaccgatg acgcaagtac ggatattgaa aatatgctgt acagcttttt 1124281 aacgaaaacg gatgaaaaac taaatgtgaa attgtcactc gctgaaagca ttaaagaatt 1124341 agacggcggc cttgcatatg atgtgaaaat taaaaaaggc gttaagtttc atgacggaaa 1124401 agaactgact gcagacgacg tcgtatttac gtacagtgtc cctttaagca aagattacaa 1124461 gggagaacgc ggttcaacat atgaaatgct gaaatccgta gaaaaaaagg cgattacgaa 1124521 gtcttgttta agctgaaata taaagacggt aatttctaca acaatgcgtt agacagcaca 1124581 gctattctgc cgaaacatat tctcggtaat gttccgattg ctgatttaga agaaaatgag 1124641 tttaacagaa agaaaccaat cggttcagga ccatttaagt ttaaggaatg gaagcagggc 1124701 caatatatta agctcgaagc gaatgatgat tactttgaag gaagaccgta tttagatact 1124761 gtgacgtata aagtcattcc tgacgcaaat gctgccgttg ctcagctgca ggcaggcgat 1124821 attaatttct ttaatgtgcc cgccactgac tacaaaacgg ctgaaaaatt caacaaccta 1124881 aaaatcgtta ctgatttggc attaagttat gtgtacatcg ggtggaatga aaaaaatgaa 1124941 ttattcaagg ataaaaaggt tcgtcaagcg ctaacaaccg ctcttgaccg cgagtcaatc 1125001 gtcagccaag tattagatgg agacggcgag gtagcttaca ttccggaaag ccctttatct 1125061 tggaactatc ctaaagatat agatgttccg aaatttgagt acaacgagaa aaaagcgaaa 1125121 cagatgcttg cagaagccgg ctggaaagat acgaacggtg acggcattct ggataaagac 1125181 ggaaagaaat tctcgtttac ccttaaaacg aaccaaggaa acaaagtccg tgaagacatc 1125241 gctgtcgtcg ttcaggaaca gctgaaaaaa atcggcattg aagtgaaaac ccagatcgtt 1125301 gaatggagcg ctctcgttga acaaatgaat cctccgaatt gggattttga tgcaatggtc 1125361 atgggatgga gtttatccac attcccggat caatatgata ttttccattc aagccagatt 1125421 aaaaagggtt tgaactacgt ttggtataaa aatgccgaag cggataaact catgaaagat 1125481 gcaaaatcaa tcagtgacag aaagcagtat tcaaaagaat atgagcaaat ctatcaaaaa 1125541 attgcggaag atcagccgta tacgttcttg tattatccta acaaccatat ggcaatgccg 1125601 gaaaatcttg aaggatacaa atatcatccg aaacgtgatt tgtataatat tgaaaaatgg 1125661 tggcttgcaa aataaatttc ccttaaaggg gagggagagc gttttctccc tcttctgttt 1125721 ttaataagga aagtaaaggg ggacaagtat atggctgcat atattatcag aagaacctta 1125781 atgtctatcc cgattttatt gggaattacg attttatcat ttgttatcat gaaagccgcg 1125841 cccggagatc cgatgacatt aatgatggac ccgaaaatca gccaggctga cagagagcag 1125901 tttattgaaa aatacggtct gaatgatcct cagtacgttc aatatttaaa gtggctaggc 1125961 aacatggtgc agggtgattt cggaacgtct attgtcagaa aaggaacgcc tgtttcagaa 1126021 ttgattatgg caagactacc caatacgctc ctgctgatgc tggtttcaac gattttggct 1126081 cttatgattt ctattccgtt cggtgtcctg tcggcaaagc ggccgtattc aaaaatcgac 1126141 tatggcatta catttacctc gtttataggc ctggctattc caaacttttg gtttggatta 1126201 attttgatta tggtgttatc ggtaaatctc ggctggtttc caactggggg tgtcgagaca 1126261 ctgaataccg aattcaatat atttgaccgg attcatcatt taattctgcc tgcattcgtt 1126321 ctagctacag ctgacatggc cggactgacg agatacacga gatccaatat gcttgatgta 1126381 ttaaatcaag attatattcg cacagcgaga gcaaaaggat ttaaagagaa cagagtgcta 1126441 tttaaacatg gattgaggaa tgcattatta cccgtcatta caattttcgg tttgatgatt 1126501 ccttcattta tcggcggatc tgtcgttgtc gaacaaattt tcacttggcc gggattagga 1126561 aagctgtttg tcgattcagc attccagcgc gattatccgg ttatcatggc aatgactgtg 1126621 atctcggcgg ttcttgtcgt tgtcggaaac ctcattgcag acatccttta cgcgattgtt 1126681 gatccgcgga tcgaatatta aaaggaggga aacagagatg tcagagctgc aaacaactcc 1126741 ctcgccggag atcaggctga aagaaaatat ttcgaaaaag ccagaaacaa tgacaaagat 1126801 tttctgggaa aaattctcga aaaacaaact ggccatttta ggtgccgtta ttctttttat 1126861 cattattatg tctgctgttt tcgccccttt aattgcacct tatccccaag agcagcaaag 1126921 cctgcttgat aaatataagg cgccgggcct tgaacatctg atgggaacgg ataaatttgg 1126981 acgtgatatt ttcagccgga tcctatatgg agcgcgtgtc tctttattgg ttggatttgc 1127041 gtccgtagtc ggttcgattt tgatcggaac ggttttagga gcattagccg gatatttcag 1127101 aggaatagtg gatgctgtca ttatgcgtgt agttgacatt gtgttatcca ttcctgatat 1127161 tttcttgttg atcacgctgg tcaccatctt caagccgggt gtggacaaat tgattttaat 1127221 tttctgtctc acaggatgga ccacaacagc acgattagta aggggagaat tcttgtcgct 1127281 ccgttcaagg gaatatgttc ttgctgctaa aacaattgga acaaaaacgc acaaaattat 1127341 tttttctcat atcctgccca atgcgttagg gccgattatc gtgtcagcta cgctgaaagt 1127401 tgggtctgtt attctagctg aatcggcgct aagctacttg ggctttggaa tccagccgcc 1127461 aatcgctagc tgggggaaca tgcttcaaga cgcacagaat ttcacagtaa tgattcaagc 1127521 atggtggtac ccgttatttc ccgggctatt tattttaatg accgttttat gcttcaactt 1127581 tgtcggtgat ggcctgcggg atgcgcttga cccgaaaaat attaaataaa aatgaatatc 1127641 atatctgtta taaaatatca ccaaatcaga aaaaagcagg tctcctttag tcagaaaata 1127701 tacaaagaga tctgcttttt atgattctta cataaaccca gtgattccag atttcctcaa 1127761 tctctttgga ataatttctc tatcccttgc ctatactgtg gacaacagtt tttataaaag 1127821 tgaggggtta gagatgttat ttcttcatga tgtgtgggtc aattggtttg aaggggaaga 1127881 aaatggctac aatgtatgcc actttcacga atggcgcaag gaagatacgg ttgagctttt 1127941 ggatcaggtg ccgctgttaa gggtgccgtc agtactgttt cattacatag aaaacgattt 1128001 gtcagagctt ccgaaaggtt tgcttgaaga cgtacatcag aaatcgtaca ttcgaaaaaa 1128061 tcatgagcgg acaaagcttg agtattgttt tgtcgtaaca gacggaatcg gcattttagc 1128121 tgttgacacg atcggctaca cgatccctgt cagaaaaagc cgtctaatcc caagacagga 1128181 gcagctcgtt tatgaaatgg taaaagatgt agagcctgaa acatatgaat ttgagccaaa 1128241 gaagctggaa tcctccaagg aatatcacat cttatcatta gcaccagaac atgtcagagg 1128301 actgacaaga aaagaacggc aaattaagca gctgatgttt atggcgcttg accaattaaa 1128361 agggctgaaa aaccgagcgg aaattggcta ctggtacaca gagtggaatc cgcatatgta 1128421 tgaacaaatc aaaaggatga gctttgaaga gatttgggac atgctgtata acgaaacaat 1128481 tgaaggctgg tcggacaaac acctagcttt ttgcgaaaac ctaataaaag gacagccttt 1128541 tttcgaaaag ctttgggaaa tggaaaacga atcaaaggtc aactgaaaaa aaccgctctt 1128601 tgcaaagagc ggttttttga ttagcgtctt tttcttccaa gacccatggc attctccatt 1128661 tttttcagca ttttgtttgc tgtccgattc gctcgttccg cgccttcatc aagaatccgg 1128721 tctaattctt cagattctat cagctcgtaa tagcggtcct ggatcggttt taatgcgttc 1128781 actacgactt ctgccaaatc acctttaaac tcgccgtagc cttttccttc gtactttgct 1128841 tcaagctctt caattgtcgt attgccgagg attgaataaa ttgtaagaag gttggaaacg 1128901 cccggtttgt tttccttatc aaatttgaca atgccttcag aatccgttac tgcgcttttg 1128961 attttctttt caagctgctt cggctcatcc agcaatgtaa tataagcttt ctgattcgga 1129021 tcagatttgc tcattttctt cagcggatca ttcagagaca tgatacgtgc accgactttt 1129081 ggaattttca cttccggaat cgtaaagatg tcgttgtatt ttttgttgaa gcgttctgca 1129141 agattccgcg tcagctcaag gtgctgcttt tgatcctcgc cgacaggtac aagatccgtt 1129201 ccgtacagca gaatatcagc ggccatcagc ggcggatatg ttaacaggcc ggagacgaca 1129261 gcttcattgc ctttggattt gtccttaaat tgagtcatcc gctcaagctc gccgatatag 1129321 gcgacacact gcatcatcca tccggcctgc gcatgtgcgg ggacctctga ctgaataaac 1129381 aatgttgctt tttctggatc aagtccgaca gctaagtaaa gcgccgcgag attgcggata 1129441 ttctttctaa gctcaagccg gtcttgagga acagttatcg catgctgatc gacgatgcaa 1129501 aaatagctgt tataatcatg ctgcagttcg acaaactgct tcattgcacc gatatagttg 1129561 ccgagcgtca ctgagccgct tggctgaatg cctgaaaaaa tcgtttgttt catgaaaaca 1129621 tcaacctcat ttcttaaaac ataataaaaa aggctcattc ttcccctgta aaaaagggac 1129681 gaatgaaccg tggtaccacc ctgattattc cattaaaatg gaatcactct gacgtttgta 1129741 acggagactg ctccggctga gcctactttt ttccagttcg gtcagctgct ccaaagtcca 1129801 ttccacattg cccgttatct gctcccagca ccgcagactc tcttcaaaca ggtgaaacgt 1129861 gtactactct ttttcatagc aagcttttct tttgattgct tcattataaa tcaattataa 1129921 ccaattgtca tcatgaaaaa acattctttt ttccagtaaa attgtaataa tataaataac 1129981 acgagtgctg taaaatcctt aaatgataac tgctatcagc gtaaaaacag gcagatatta 1130041 tatgtaaaaa gcaatatggg cagaaaacac atgaaaaagt ttttaatcaa tttatgcttt 1130101 aaatggtaga aggatattat gttcatggaa gaaaaactaa cgaagtttaa atattttaaa 1130161 ttgataaaat aatattgcaa taaattattt gtttcattat aatgaacttg ttcactctat 1130221 tgttacagct tttttacaaa aataatcaga aaagacggaa cagaataaaa gttgtggaaa 1130281 ctcaggttca tttgtctgat atttctgagg atttagccgt aaggagctga aaattattat 1130341 tagggggttt gcgaatatga aaaaacgttg gtcgattgtc acgttgatgc tcattttcac 1130401 tctcgtgctg agcgcgtgcg gctttggcgg cagcggatca aacggtgaag ggaaaaagga 1130461 cagtaaagga aagacgacac ttaacattaa tattaaaact gagccgttct ccttacatcc 1130521 gggattggca aatgattcag tatcaggcgg tgttatccgt cagacttttg aaggattgac 1130581 acgtatcaat gcagatggtg agcctgaaga aggcatggct tctaaaattg aaacgagcaa 1130641 ggacggaaag acatatacat ttaccattcg tgatggtgtg aaatggtcta atggagaccc 1130701 tgtaactgca caagattttg aatatgcttg gaaatgggcg cttgacccta ataatgaatc 1130761 acaatacgct taccagctct actacataaa aggtgctgaa gcggcgaata ccggaaaagg 1130821 cagcctagac gatgtggcag taaaagctgt gaatgacaaa acgctgaagg ttgaattaaa 1130881 taacccgact ccatatttca ctgaattaac tgcgttctat acgtatatgc cgatcaataa 1130941 gaaaattgca gagaaaaata aaaagtggaa tacaaatgcc ggagatgatt atgtatcaaa 1131001 cgggccgttc aaaatgacgg catggaaaca cagcggctct attactctcg aaaaaaatga 1131061 ccagtattgg gataaagaca aagtcaaact gaagaaaatc gatatggtta tgatcaacaa 1131121 taacaatacg gaactaaaaa aattccaagc tggcgaactt gattgggccg gtatgccgct 1131181 cggacagctt ccgacagaat ccctgccgac cctgaaaaaa gacggttctt tacatgttga 1131241 gccgattgca ggagtgtatt ggtacaaatt caacactgaa gctaagccat tagacaacgt 1131301 caatatccgt aaagctttaa catattcgct tgaccgtcag tcgattgtta aaaacgttac 1131361 gcaaggagag caaatcccgg caatggctgc agtgccgcct acaatgaagg gatttgagga 1131421 taacaaagaa ggatacttca aagacaatga tgtcaaaaca gcaaaagaat accttgaaaa 1131481 aggcctaaaa gaaatgggct taagcaaggc atctgatttg ccaaaaatca aattgtctta 1131541 caacactgat gacgcacacg cgaaaatcgc tcaagcagta caagaaatgt ggaagaaaaa 1131601 tttaggcgtt gatgttgagc ttgataactc agagtggaat gtctatattg ataagctcca 1131661 cagccaagat tatcaaatcg gccgtatggg ctggctcggc gacttcaatg atcctatcaa 1131721 cttccttgaa ttgttccgcg acaaaaacgg aggaaataac gatacaggct gggaaaatcc 1131781 agaattcaaa aagcttctga atcagtcaca aactgaaaca gataaaacaa aacgtgcaga 1131841 gctgctgaaa aaagcagaag gtattttcat tgatgaaatg ccggttgccc caatctattt 1131901 ctatactgat acttgggtac aggatgaaaa cctaaaaggt gttatcatgc caggtactgg 1131961 tgaggtttat ttcagaaacg catattttaa ataaggctac gtctgaaaat aaaagacctc 1132021 aaggtatatg gggagaaaag ccccatatac ctttcttact gatggagtat aaaaatgtaa 1132081 aaaccatgga ggtgttcccc cttgctaaaa tatatcggaa gacgcttagt ctatatgatt 1132141 atcacactat ttgtgattgt aactgtgaca ttcttcttaa tgcaagcagc accgggcggg 1132201 ccattttcag gtgagaaaaa gcttccgcct gaaattgaag caaatttaaa tgcgcattat 1132261 ggcttggaca agccgctgtt tgtacaatat gtcagttatt tgaaatcagt tgcaatgtgg 1132321 gatttcggac cgtcatttaa atataaaggt cagagtgtta acgacctgat cagttcaggt 1132381 ttccccgttt catttactct tggagcagaa gctattctcc tcgctttagc gttaggtgta 1132441 ttgtttgggg tcattgcagc cctttaccat aataagtggc aggattatac cgtcgcgatt 1132501 ttaacgatat ttggtatttc ggttccgagc tttatcatgg cggctgttct gcaatatgtg 1132561 ttctccatga agcttgggct gtttccggtc gcggggtggg attcctgggc atacaccttt 1132621 ttgccttcca tcgcacttgc ttccatgccg atggcgttta ttgccagact ttcccgttca 1132681 agcatgatcg aagtgttaaa cagtgattat atccgcacag cgaaagcgaa agggctttcc 1132741 cgcccagcgg ttacagtgcg gcacgccatt cgaaacgcac ttttgccggt tgttacatat 1132801 atgggcccga tggccgcaca ggtcttaacg gggagcttca ttattgaaac catttttggg 1132861 attccggggc ttggtgcaca cttcgtcaac agtattacaa accgtgatta tacggtcatt 1132921 atgggtgtaa cggtgttctt cagtgtcatc ttgctattgt gtgtattaat cgtagatgtg 1132981 ttatacggca ttattgatcc aagaatcaag ctttccaaag caaagaaagg agcctaggcc 1133041 atgcagaaca ttccaaaaaa catgtttgaa ccagccgcag cgaatgccgg cgatgcagaa 1133101 aaaataagta aaaagagcct ttccctctgg aaagatgcga tgcttcgctt ccgcagcaat 1133161 aagcttgcaa tggtcgggct tatcattatc gtacttatta tccttatggc aatttttgcg 1133221 ccgatgttct caaggtatga ttattcaact actaatctct taaatgcgga taagccgcct 1133281 tcaaaagatc actggttcgg aacagatgat cttggacggg acattttcgt ccgtacatgg 1133341 gtaggggcgc gaatctcaat ctttatcggt gttgcagctg ctgttctcga tttgctgatc 1133401 ggcgtcattt gggggagcat ttcaggcttc cgcggaggaa gaacagatga aatcatgatg 1133461 cgtatcgctg atatcctttg ggcagttcct tcattattaa tggttatctt actgatggtt 1133521 gttcttccga aaggtctatt tacgattatt attgccatga cgattacagg ctggattaat 1133581 atggccagaa tcgtgcgcgg acaagtgctg cagctgaaga atcaggagta tgtgcttgct 1133641 tcacagacac tgggtgcaaa aacatcccgt cttctattta aacatatcgt gccaaacgca 1133701 atgggttcta ttttggtcac gatgacactg acagttccta ctgcgatttt tacagaagcc 1133761 tttttaagct atttgggact tggtgttccg gctccgctgg caagctgggg aacgatggct 1133821 tctgacggat tgcctgcatt gacctattat ccgtggcgtt tattcttccc tgccggattt 1133881 atctgcatta caatgtttgg ttttaacgtt gtcggcgacg gattaagaga cgcattggat 1133941 cctaagttac gtaaataagg gagtgatacg ggtgacacgc ctattagaag taaaagattt 1134001 agcaatttca tttaaaacat atggcggaga ggtccaggcg atccgcggag tgaatttcca 1134061 tctggataaa ggggagacgc tggccattgt tggagaatca ggttccggaa aaagtgtaac 1134121 ctctcaagcg attatgaagc tgattccaat gcctccgggt tatttcaaac gcggtgagat 1134181 cctgtttgaa ggaaaggatc tggtgccgct gtccgaaaaa gaaatgcaaa atgtccgggg 1134241 aaaagagatc ggcatgatat tccaagatcc gatgacctct ttaaatccaa cgatgaaggt 1134301 cggtaaacaa attacggaag tgctttttaa acacgaaaag atctcgaagg aagcggctaa 1134361 aaaacgcgcg gttgaactgc tggaattagt cggtatccca atgccggaaa agcgggtgaa 1134421 ccaatttccg catgaatttt caggcgggat gagacagagg gttgtcattg ccatggcgct 1134481 tgcagcgaat ccgaaacttc tgatcgccga tgagccgaca actgctcttg atgtaacgat 1134541 tcaagcgcaa attttggaat taatgaagga tttgcaaaag aaaattgaca cgtccatcat 1134601 ctttatcaca cacgatcttg gtgttgtggc taacgttgct gaccgggtcg ctgtcatgta 1134661 cgcgggacag attgtagaaa ctggtacggt agacgaaatc ttctacgacc cgagacatcc 1134721 gtacacttgg gggcttcttg catccatgcc gacactggaa agttcaggag aggaagagct 1134781 gactgcaatt ccgggcacgc cgcctgattt gacaaacccg ccaaaaggag atgcttttgc 1134841 cctgcggagc tcttacgcga tgaaaatcga ttttgaacag gagccgccaa tgtttaaggt 1134901 atccgatact cattatgtaa aatcgtggct gcttcatcct gacgcgccaa aggtagagcc 1134961 gcctgaagcg gtaaaagcga aaatgcgtaa actggcaaac acgtttgaaa aacctgtctt 1135021 agtgagagaa gttgaatgaa ttgactgaaa aactattaga aatcaaacat ttaaaacagc 1135081 actttgtcac gccgagggga acggttaagg ctgtagatga tttatcattt gatatctata 1135141 aaggtgaaac attagggctg gttggtgaat ctggctgcgg taaatcgaca acaggccgaa 1135201 gcattatcag gctgtacgaa gcaaccgatg gtgaggtgct gttcaacggc gaaaatgtgc 1135261 acgggagaaa atcgcggaaa aagctgctgg aattcaaccg caaaatgcag atgattttcc 1135321 aagaccccta tgcatccctg aatccgagaa tgacagttgc tgatattatt gctgaaggcc 1135381 ttgatattca taagctggca aaaacgaaaa aagagcggat gcagcgagtt catgaactat 1135441 tggaaacagt gggattgaac aaggaacacg cgaaccgcta tcctcatgaa ttttccggcg 1135501 gccagcgcca aagaatcggg attgccagag cgcttgctgt tgatccggaa ttcattatcg 1135561 cggatgagcc gatttccgct ttggatgtat ccattcaagc gcaggtcgtg aatttaatga 1135621 aagaactgca aaaagaaaaa gggctcacat acctgtttat tgcccacgat ttatcgatgg 1135681 tcaaatacat cagtgaccgc attggcgtca tgtatttcgg gaaactggtt gagcttgcgc 1135741 cggcagatga gctttatgaa aatccgcttc acccatatac aaaatcattg ctttctgcga 1135801 ttccgcttcc tgatccggac tatgagagaa atcgcgttcg ccagaaatat gatccgtctg 1135861 tccatcaatt aaaggatggg gaaacgatgg aattccgtga agtcaaaccg ggacattttg 1135921 tgatgtgcac ggaagccgaa tttaaagctt tttcatgatt catcaatcct tcaagagatt 1135981 tctcttgaag gatttttttg cgtcttcata gaaagtgaga atgataacat ttacaattag 1136041 aggaaaaagc ggaggcgaaa tacgattcaa tttctgcata acaaaaatgt ttttgcgcta 1136101 ttgctgtctc aatcttttca atctttagca ggagtcctcg tcacaatcgt tttaatggtc 1136161 cggatctatc aaatgactga ctccgttttt ttggcgggcc ttattttatc gttcatgtcg 1136221 tttgcgagta tagcagcaag cttttgcgtc tctccggtgc ttcgcattct cggttttaaa 1136281 aaggtgcttg cgggagcgaa tctgctgaga gcggtcttta ttatactgat ggcatacagc 1136341 gtcactcatc acggacaggc attcttttgg attacgctgc tgtttgtgtt ttgtttttcc 1136401 ttcgcgggcg ctttttttca gccggcaaga tttgcgctgc tgccgattat tgttccaaag 1136461 aagcaatatg taaaagcgaa tggtgtgatc tccctctcga atcaattgtt cttaacagca 1136521 ggctggggcc ttggaggcct tctgacgtac gccgtccctt ttgaactcgt tgtcggcgct 1136581 gccatttgcc tgtttgttct atcgggagct tccatcagtg tgctgcatgt aaatgaagaa 1136641 gaggctgcag gaactgctga aacagcatct gtcagaagta tatggaagga tttaatgatc 1136701 atccctattg taagagacat tactgtaatg gacatgttag aagctttggc gggttccgta 1136761 tggtcatctg ctattctcct cgcatttact gcggctgttt tgcatgaaac agaggtgtgg 1136821 tgggggatgt ttaacgcttc ctattttata ggcgcaattg tcggcagtgt gattgctatt 1136881 cgtttttctt ctttttttga gcggaatatg ggctatgcca ttatgttcag ctcgcttgta 1136941 atgtcggcgc tgaccctttt gttttcattt tctccagtcc catttttatg cgctctggct 1137001 tgtgctgcaa tggggccttt ttatcaggtg cgtgatattt gccaggaaac catgctgcag 1137061 gaagttattc ccgagcagaa acgaatcgga atcatggctg caaaaaatgc gattttgact 1137121 ccttggtcag gcgtcaccta ctccattatg gggctagtgg ctgatgctgc tggtgcgaaa 1137181 atagctttta tcgcggctgc tgcattatat atcatgacat ttctgattgc actggcgcag 1137241 ccccgtctgg ttcattacag gcgagaaaat cgagttcaat gagaaacact tcaaaatgaa 1137301 cggagcagct ggctccgttt tgctgaaaaa aaaatgaaac catggcggaa gttcgcacgt 1137361 ctttatagat gtaaggctgt ttaaacaaga agaaatgggg tatatctaaa agtatgaaga 1137421 caacgaactc ataaggagca aatcaatgaa ctggtatgaa aagcttagcg agtactttcc 1137481 aattgaagaa atgaaatcaa aagcgcatat ggaagctctt ctgaaagagc gaagcgatat 1137541 ttatcataaa gatgaaggca aacatcatat tttaatgttt gcggaattcg attcttttat 1137601 cttcgttgat tatctgtatg tgtctaagga tgcaagaggg caggggcttg gcggcaaatt 1137661 gatcgcgaag ctgaaaaaga aaaataagcc catattgctc gaggtggaac ctgtggatga 1137721 agatgatact gatacagaaa aacgcctgag gttttatcaa agagagcatt tcaagcatgc 1137781 tcagtcaatt gggtaccggc gccggtcatt ggctacgaat gaagtaaaca agatggagat 1137841 tctgtactgg tcaccaaaaa cagaatcaga agaagaaatt cttgaagcca tgaaacagac 1137901 atatgaaaac attcatactt ataaagatga gaaatggtac ggagaatcgt acgaaaaaac 1137961 ggatgaggtc ttggaaatca tcgatgaaga aaaacaaaaa aatattttcg atcagttaag 1138021 ctaattgaga ataagaacat atcatgaaca ttaaaaattt gctggattga cacatttttt 1138081 tcttaggata ctgttcacac ttactttttt atagtataat acctgtaaag attccttttt 1138141 tagagtaatt tcaatttaag aataaaatag atgttcatcc tactaattag aggagtgaag 1138201 atgaatggtt acactataca catcaccaag ctgtacttca tgcagaaagg cgagagcgtg 1138261 gctcgaggag cacgagattc catttgtaga aagaaacatt ttctctgaac ctttatcaat 1138321 tgatgaaata aaacaaattc ttcgaatgac tgaggacgga acagatgaaa tcatctcaac 1138381 ccgttcaaaa gtattccaaa aactgaatgt gaacgttgaa tctatgccgc tgcaagattt 1138441 gtaccgcttg atcaacgagc atccaggttt gcttcgccgt ccgatcatca ttgacgaaaa 1138501 acgtttgcag gtcggatata acgaagacga aatcagacgt ttcctgccaa gaaaagttcg 1138561 ctctttccaa ttaagagaag cacagcgttt ggcaaactaa tagatcgtat catcaaaaga 1138621 aggctgagtc atcagccttc ttttattttt caacctgctg gtaataaatg ctcgcaagga 1138681 tgacaaacgc aaccgtcaaa atggggagga gcgtttcgac tgtgccgtgc tgcgccataa 1138741 aaagcgacag ctttttgtct ctgacaatca tttctccgcc agtataagca agcagcccgc 1138801 ttcccgcgta aatcagaagc ggtattttct ctagtgcaat atggatgagt ttgctgcccc 1138861 aaataataac cggaaccgat acacacaatc ctataacaac gagagaaaac tcaccgtgtg 1138921 aagctcccgc aactgcgatg acgttgtcca gcgacataaa gagatctgca agcacaatcg 1138981 ttcgtatcgc tctccacagg gaggtgctgc ttttaatgtg tttcgtgtct tttttttcaa 1139041 tcagcagctg atatcctaaa tacagcagga aaattccgcc ggcgcactgc aagaacggaa 1139101 tgttcaaaag atatactgct gcacttgtta atccgattct catggcaacg gcaataaatg 1139161 ttccgagaat aatggcttgc tgtctttgct tgtccggcaa atgtctgctg gccatggcaa 1139221 taacaaccgc gttatctccg ccgaggatca ggtcaatccc aacaatgacg agcagagaaa 1139281 tcagatagtc atgctccatg aagcggcacc tcgctttcag tccttcgctt gtactactac 1139341 tatatgagac aggtcatatt ttatgatatc agccgcctga tctgccgttt tttaggcaaa 1139401 ggtgcatttt tatttctttt gtgactgttt tatcataaaa tagaaataca aaggaattca 1139461 cactggcctt ggttaaggtt aagatgtgga cggaatgggt aaagtgtagt aaagtacaat 1139521 taatcgggag cttagatgtc ccttcaacat cttatataga agggaaggtt ggcaaatgga 1139581 aattgaaaga attaacgagc atacagtaaa attttatatg tcttacggag atattgaaga 1139641 tcgcggtttt gacagagaag aaatttggta taaccgtgag cgcagtgaag aacttttctg 1139701 ggaagtcatg gatgaagttc atgaagaaga ggaattcgct gtggaaggcc cactttggat 1139761 tcaagttcag gcactggaca aaggattaga aatcatcgtc acaaaagccc agctttccaa 1139821 agacggacaa aagctcgaac tgccgattcc tgaggataaa aagcaagaac cagcatctga 1139881 ggatcttgac gccttgctgg atgatttcca gaaagaagag caagccgtca atcaggaaga 1139941 gaaggagcaa aagcttcaat ttgtcttgcg atttggcgat tttgaggatg ttatttctct 1140001 atctaaattg aacgttaacg gaagcaaaac gactttatat tcgtttgaga accgatatta 1140061 tttatatgta gatttttgca atatgactga tgaagaggtt gaaaatcagc taagcatcct 1140121 gctggagtac gcaactgaat cctcaatcag catacaccgt cttgaagagt acggcaagct 1140181 gattatttca gagcatgctc tagaaacgat aaaaaaacac tttgcatcat agcaaaccga 1140241 tttccttccg gaaatcggtt ttttttatgc acgaaaatgc cattttagag atgtgaaaaa 1140301 tcaaaaacat atagacaagc agaaaataca gcgaacagga gttgatcatc ttttccagaa 1140361 agtatacttc atctggaaag gagagatgac aattgtttag tgctgtgact gaagacggcc 1140421 aaatgtttca ccttctaggc gctcagcaaa accagaaatt aaagcggaga cggttcttct 1140481 gtccggtatg cgggggagag ctagctgtga agctcggact tcaaaaagcg ccgcattttg 1140541 cccataaaca gaacaagtcc tgcgccatag acatcgagcc ggaaagcgcc taccacttag 1140601 aaggaaaaag acagctgtat gtatggctga aaacgcaacg ggcttcacca atattggagc 1140661 cgtatataag gacaatcaac caaagaccgg acgtcatggc aagaatcaag gagcatatgc 1140721 ttgctgttga atatcaatgc gccactatcg ctccagatgt ctttcaaaag cggacagagg 1140781 gcttcaaaca agaaggaatc atcccgcagt ggattatggg atacagccgc ttaaaacgga 1140841 ctgcttcgtc cttttatcag ctttcaactt ttcattggca gtttatcaat gcaagtccat 1140901 acagagaact gatatgttat tgtcctgaaa ggcgttcttt tctccggctc agccacatca 1140961 ttccattcta cacaaaccat tcttattcct cagtccaaac gatccctatc catcgggcag 1141021 gtgcaggcga tctttttttc actgaaccga aaccctcaat tcaatattca ggctggacga 1141081 aagcgattca ccgttttcgc cataaacccc atcggtttaa ctcaaaggaa acaaatcgcc 1141141 ttaggctgct gttttatgag aaacgacaga cgcctttttc ttttctgccg actgaagtgt 1141201 ttgttcctgt tagaaaaggg gcagttttta agagtccggt ttttgtgtgg caggggtttc 1141261 tttatttgtt tatgacggat cttggaggta aacgtgcgcc aattcgtttt tcagccgttt 1141321 tgcagcagtg caaactgcac attcataata agaacattgc actcaggtcc gaatgcagcg 1141381 aagagtgtct ttcagaagcg gttaaacagt atattgattt tttgtgcaag aagggatttt 1141441 taagggagac tcagaaagaa gtatatgtgc tgaatcagcc tgcaggaggc atacactcca 1141501 tgcaggatct catagaaaga gaccgcagct gttttataga atgagtttgt cttatttggc 1141561 tcaccctaag acaaaggtgg tgggcaggct gtgaaaggca caaaaggaaa ggtttttcgt 1141621 gtttttactg cttttttggc attcgttctc ttcattactg catatgattt gacaaaaggc 1141681 agtgaaaaac cggaagatat tcacaacaca agtttattga gaaacagctg ttttttcaat 1141741 tggcttgaat caaagaagac gagggggatc accatggctg aggaaaaaaa agcaaaccaa 1141801 ctgcctgaca gaagtgaggt aaaggcagaa gacacatgga gacttgagga tatttttcct 1141861 agtgatgagg cctggaataa agaatttcaa gctgtaaaag aattaattcc gaatttatct 1141921 aagtataaag gaaagctggc agattcagct gatcatttat acgaggctct tacgtatcaa 1141981 gataaagtga tggagcggct aggtaggctg tacacatatg cgcatatgcg ctctgaccag 1142041 gatactggga actcctttta ccaggggctg aatgacaagg cgggaaacct gtatacacag 1142101 gccgcaagcg cgacagctta tttggttccg gagattttat ccatagaaga agacaaactg 1142161 cagcagttca ttcttgaaaa agaagaattg aagctgtact ctcatgcgat tgaggagatt 1142221 acaaaggaac gtccgcatgt gctgagcgag aaggaagagg cgctgcttgc tgaagcctcc 1142281 gaggtactgg ggtcatcttc aaatacattc agcgtgttaa ataacgcaga tataacgttt 1142341 ccatccatta aagacgaaga tgggaatgaa aaacagatca ctcacggcaa ctttattaat 1142401 ttcttggaaa gtgaaaaccg tgaagtccgc aaaaatgcgt ttgacgcagt gtataaaacg 1142461 tacggacaat ataaaaacac aatggccacg acgctaagcg gcactgtgaa aaaggacaac 1142521 ttctacgcga gagtgaaaaa gtacaagtcc gcgcgtgagg ctgcgctttc taacaacagt 1142581 attcctgagg aagtatacga taaccttgtt aagacgatta ataagcattt gccgctcctg 1142641 caccgctata ttgcgctaag aaagaaagtg cttgagcttg atgaagtgca tatctatgac 1142701 ctgtatacac cgcttgtgaa agatgctggg atgaaggtga catacgagga agccaaagat 1142761 tacatgctga aaggcctcgc acctttaggg gaagaatatg cctctatcct aaaagaagga 1142821 ctggaaaacc gctgggtgga cgtttacgaa aataaaggca aacgcaatgg ggcttattca 1142881 tcaggagctt acggcacgaa tccgtatatt ttgatgaact ggcataataa cgtcaataat 1142941 ctctttacgc tcgtgcacga gtttggacat tccgtacaca gctactatac gagaaagcac 1143001 cagccttatc catacggcaa ttacagcatc tttgtcgcgg aagttgcctc tacgacaaat 1143061 gaagcgctcc ttggcgaata tttgctgaac aatttagagg atgaaaaaca gcgcttatat 1143121 attctcaacc atatgcttga gggcttcagg ggaacggtct tcagacaaac gatgttcgct 1143181 gaatttgaac atctgattca tacaaaggcg caagaaggcg agccgcttac acctgagctt 1143241 ctgacaaatg tctattacga cctgaataaa aagtattttg gagacggcat ggtgattgat 1143301 aaggaaatcg gccttgaatg gtcgcgtatt ccgcacttct attacaatta ctatgtgtat 1143361 cagtatgcga caggttacag cgctgcccaa gcattaagca gccagatttt gaaggaagga 1143421 aagccggcgg ttgaccgtta tattgacttc ctgaaagcgg gaagctcaca atacccgatt 1143481 gatgtcctga aaaaagcggg tgttgatatg acgtctccag agccaatcga agccgcgtgc 1143541 aaaatgtttg aagaaaaact tgatgaaatg gaagagctgc tgatgaaagt caagcagtct 1143601 taaaaaagta agcctgtgcg gaaatgacgc acaggctttt ttaaaaccct ttaaaggttt 1143661 tccggtgatt caagcggtag agggtaaaca aaatagacag aaacagcaga ggagaggtaa 1143721 tataaagcgg cagcatatgc atcatgccta agatattcaa gcagaaaaaa acagcaatgc 1143781 acacaattga gatcaaagta gacatcatgg cggtcctcct cgtccttttt ccttataagg 1143841 atatgagtga atgcacttcg ttatgttttg tgacaaaaat atgaacatta agcatagagg 1143901 ttgtcaaaag tcgacatctt ttgttatcat aaggatgtga aattgatcac aaacaaacat 1143961 tacccctttg tttgaccgtg aaaaatttct cccatcccct ttgttgtcgt taagacatat 1144021 gaaaccgcgc ttatcccggc gcggtttctt tagtgctaaa aatggaacgt acgtttggtt 1144081 atggcataaa aaaacagcct caagcatatg cacgcctgcg gctatttttc acatgattga 1144141 tattcatcag aataagtgct gagagacttc caaaacattc cgtgtttggc ttccactttg 1144201 gcaacctttt tagcaaacgc cagttttttc atttcttttt ctacctcttc aaggctcagg 1144261 tcatatacaa gagcaatttc cttcgaggca acgaagcgga aatattcaat aaaacattct 1144321 aaaggcggtg tttccgacgg cttcggctcg tcgccaagca tctcaaataa aatttcttca 1144381 tatacatcat atgagtagct gccaggaact ttaagccctt catcctcatg ctgcgtatta 1144441 aaaaacgtca gtgtcggatt aacagaaaca tccatctcgg cagcaatttt catgtcacat 1144501 tgaagcgcct tgaccgcgct ttgagaatgc agatcttttt tgaattcttc aagatcgaga 1144561 cttgtatttt cagcaatctc caaaagcacg ttttcatccg taatattttt ctttgaaaca 1144621 aataggctct cctgcatatt tctgagaaat tgcatgccgg cttttcgtcc ttgcagttcg 1144681 gctgctttaa aagcgagagc agccatataa ggcgatgaaa gcggctgatc ctgttcgaac 1144741 cagacattgc cgtcacatga catgccagag cggctcgcga tcttttccca tgcttctgcg 1144801 agaagatgct tttttcgctt tttatttaaa gcggtaaggc ttgcggaagc gataatgcgt 1144861 aaggtgaaaa aacgtccgta tctgattttc agctttttga tgacgggctc taaggaccag 1144921 cattcaggac ataaagggtc tacaaacata taaatttcaa gcggtttttt tggatgaccg 1144981 tggcaatggg cgaagtatag ctcatgctga tagtttgtca agatgatcga tcctccgctt 1145041 ccgtttgatt caccatatgc cttgctgtca actccagccg gccaaacaaa aactcacgaa 1145101 tttcgccctc cagccctaca tggtccattg cgtccttcat acagctgagc cacgcatcag 1145161 ctctctcgtt tgtaattgga aagggaagat gccttgctct gagcatagga tggccgtgtt 1145221 cctcagtata aagaggaggc ccgcctaaat actgagttaa gaattgcttc tgtttcctgg 1145281 cggtttctgt caaatcgctt ggaaaaatcg gcttcagcaa aggatgagac gcgacacgct 1145341 cataaaaagt atcaacaagt tgcgatagaa gttcctctcc aatcgcttca taaggtgcgt 1145401 taaacgattg tcccatgttg actactcctt taaatatggc taataggaat cataaatcct 1145461 attgcaaaaa gtaattttct gtatttcatt gtttcatcta gatttatttt agcaacaagg 1145521 catcatttct acaaacaaac tgccttttat gcgtttgatg actcatttcg gctgacagcc 1145581 ggggtttgta tttcatatca tatcacataa aaatcaggaa tgcgtaagat ttcacttcgc 1145641 aaaaaaacca gagggaaaga gcacctctgg ttacgcgtaa taaactgaag ttattttttt 1145701 tacatagttt tgcgtttctt ggaaaggagg aatgcctccg tatcggtcaa cattccccgg 1145761 tccggcgttg taagccgcta atgccataga cacattgccg tcgtatttat ccagcatttg 1145821 ttttaaatat ttcgttccgc cctccacatt ttgctgcgga tcaagcggat tggaaacgcc 1145881 aagtgagctt gctgttgacg gcatcagctg catgaggccc atcgcacctg ctccgctgac 1145941 cgcttttgca ttaaagcctg attcctgttt gatgacggcg cggatcagtt tttcatcaac 1146001 gccatattta tcagcggctt ttttaatcgc actgtcaata gagaagtctc ccgaacggat 1146061 ctgatttgct tcatgtttgt ttgaagctga atctgcaaca gctgtttcag tgctttctgc 1146121 cgcttttgtg actgaacctg aattgctgct cgtatatgag ttaagcccat acgctgaaag 1146181 cagtgacggc gctgttgtat tcgcgctgtt cagcatgctg agcgggcttg gcgatgaaga 1146241 aggtgctgat tgctgagatg tcagaccgtt tgtatattgg ctgagcaaag aactgaaact 1146301 tgaaagcggg ctttccgtat tctgagtgtc cgagctgctg cgtgcattag atatggactg 1146361 taatgcctga agctgaagta atgctgccca attcgttaca ttcacgatgt cattccacct 1146421 tatatagact ttcgtttttc ttcataaaaa cgcagaattt tatttttggt ttcgcgctga 1146481 ggaatgctga attgctgaag cagcttttcg aaggcttgtc tgccctcatg ccaatccgcc 1146541 gcctcaaatt caatttcata gtcctcttta tttaaatatc ggctgtggtc taaaactatt 1146601 aagccttttt ctgtttcttt ttccgcacgg tttgttgcta aagatccaaa gtattgtatg 1146661 gcatccgtat cgatctgaag cttgtgcagc tggtccttca cagggccctc gggaactgaa 1146721 aatccagcga gatctgatac ctctgaaagc tgctggtgcg tttccagaag ccccacatca 1146781 gccggctcct ttaatgtaag gacatacttt ccgttttttc tgcggatacg aagcgcagca 1146841 tgtttttgtt tcagcgcgaa gctgtctgta tcaaaataat gattcttttg atctgtaaaa 1146901 tctttttctg tcagctggag tgccgatgct atgtttttga attcttgttt ggtcagcatg 1146961 tttttaaatt cgatttcaat ctcttggctc atgatgctct tcctttccgc cctgtaaatc 1147021 ttatttttac tattatctct ttagatgtta ggtttatcaa tatcgagctc gatatgataa 1147081 aatgaatctg tactttgttt aaaaaaggag agcattatgc aaaacagaat cgaaattttg 1147141 aatgcaacat tatcggatga tcagcttcgc cttgcctgtc agacagaagg aaacgaagcg 1147201 gaacgcaagc cgtcaggtca aatgcttgtt gattctgacc actttgcttt tgtatacata 1147261 cttgaattag ctgattcttt tgaatatgtc attataaagg aacatgtatg gccggaactg 1147321 aagcaggccc atgcacaaaa aataccggtt gttttagagg caggagacca aacaattgaa 1147381 ctggcaggcc tgcatgagga gctggaatat cttttagaaa atataaaaga taatgcaaac 1147441 tatggagaag aaatggaaga aaaagtgaaa cgcgtgtttt tatagaaact ggttcggaat 1147501 tgggggatgt atgatggatg acaaacaatg ggagcgtttt ttagtgccgt accgccaggc 1147561 tgtcgaagag ttgaaagtga agctcaaggg gatccgcaca ctatatgaat acgaggacga 1147621 ccattcaccg atcgaatttg tgaccggacg cgtcaagcct gtggcgagca tacttgaaaa 1147681 agcgagacgg aaaagcatac cgctgcatga aattgaaacc atgcaggaca ttgctggcct 1147741 tagaatcatg tgccaatttg tcgatgacat ccaaatcgta aaagagatgc tttttgccag 1147801 aaaagatttc accgttgtgg atcagaggga ttatattgcg gaacataaag agagcggata 1147861 ccgatcatac catcttgttg tgctgtaccc tttgcagacg gtatccggag aaaagcatgt 1147921 tctcgtagaa atacagatcc gtacactggc gatgaatttt tgggcgacca ttgaacattc 1147981 attgaattat aaatacagcg gaaacattcc tgaaaaagta aaactaaggc ttcagcgcgc 1148041 ttctgaagcg gcttcccggc ttgatgaaga gatgtcggag atcaggggtg aagtacagga 1148101 agctcaagct gccttttcaa gaaagaaaaa aggaagcgag caacaatagg taaaggggaa 1148161 gaagagcatg aaatttgccg tatcatcaaa aggagatcaa gtttctgata cgctgaaaag 1148221 caaaatacag gcgtatttat tggattttga tatggaactg gatgaaaatg aaccggaaat 1148281 cgttatttca gtcggaggcg acggaacgct tttgtatgct tttcacagat acagcgaccg 1148341 tttggacaaa acagcatttg tcggcgttca cacaggtcat ctgggttttt atgccgactg 1148401 ggttcctcat gaaattgaaa aacttgttct tgccatcgcg aaaacgccgt atcatacagt 1148461 cgaatatccg cttctcgaag tcattgtgac ctatcacgaa aacgagcggg aagaaagata 1148521 cttagctttg aatgaatgta cgattaaaag catcgaagga agccttgttg ctgatgtgga 1148581 aatcaaaggg cagctctttg aaaccttccg gggcgacggc ctctgcctgt caactccatc 1148641 aggcagcaca gcctacaata aggcgctggg cggagcgatt atccatccgt ctatcagggc 1148701 gatccagctt gcggaaatgg cttcaattaa taaccgcgtg ttccgtacgg tcgggtcacc 1148761 tctgcttctc ccatcccatc atgattgcat gattaagccg agaaacgaag ttgactttca 1148821 agtgacgatt gaccatttaa cccttctcca taaggatgta aagtcgatcc gctgccaagt 1148881 tgcatccgaa aaagtgcggt ttgcgagatt ccgtccgttt ccattttgga aaagagtcca 1148941 ggattcgttt attggaaaag gtgaatagaa agaggacata tcgtggagca tttttttatc 1149001 agaaagaaca ttacttccgc tgaggacggg atgactgtaa aagaatatgc cggtgaactg 1149061 ggaatttcga aacgtctgct gaccgatatt aagtttggcg ggggagacct gcagattaac 1149121 ggtgagcatg tgacggtcaa atacgttttg aaagagggag atcttcttat cgtgaagttt 1149181 cctgaggagc aggtgagcga gacgctgttg gcagagcctg ttccgctcga tatcctttat 1149241 gaggatgaac atgtgcttgt gataaacaag cagccgtatg tgtcatcaat cccttcgaga 1149301 gagcacccct ccggcagcat tgccaatgga attattgatc attatcaaac aaccggagtg 1149361 agggcgacag ttcatcttgt cacccggtta gaccgggata catcaggtat catgcttgtt 1149421 gccaagcatc gatttgccca ctccatttta tcgtctgcgc aaaaaaacgg ccttgtgaaa 1149481 cgccggtatg cggcagtggt tcacgggcgg atggcacaga tggagggaac agtcgatgct 1149541 ccgattggca gacatcctga cagtattatt gaacggacgg taacgccaga cggccagaag 1149601 gctgttactc atttttacgt cacatgtgca aatgatgaca tgacctcggt ggcattgcag 1149661 cttgagactg gacgaaccca tcaaattcgt gttcatatga gctatctcgg gcacccgttg 1149721 tgcggcgata cactgtacgg cggaacgaga caggaaattg gccggcaggc tctgcacagc 1149781 gagcatcttt cgtttatcca tccgctgaca caggagaaca tgaggtttca tgctccactg 1149841 cctcaggaca tgagcaaact gataaaagga gagaatcatt gattctctcc ttttttatat 1149901 ggggcgaaat cttgattcgt cgtaaggcag ggagcttgga acagagacgg tttctatttc 1149961 tggaaagcga aagcctgtca gttgatttcc gaacacgcag cctgtatcaa tgttgatggt 1150021 gcgattgacc ttccgaggct ctttcacagg tgtatgaccg tataccaccc aagcctttcc 1150081 gttataggct gccgcccaat cacgcctgat gggtctgccg tccggatatg tttcacccgt 1150141 cacgtcaccg taaagcacaa agtccttcac tctgcgggta tatttgccga tatcgtcagc 1150201 tcttatgcca gcatgggcga caactaattc tccattatgt aagatgtcgt aaagcggcgc 1150261 tgtttcgtac agcttcataa actgttcgct gactgatttt ttctcatctt tggaaagttc 1150321 ctcaagctct gccgctgttg tttcgagacc atgcatcact tttaccggat ttccttttaa 1150381 gtaacgatat aatttattgc aatggtttcc cgggacataa cgcacagcgc ctttttcgta 1150441 agcgccggct acaaatcgga tgacctctat cgatttgggc cctctgtcag ttaaatctcc 1150501 ggcaaaaaca agcaccctgc cttcttcatg gacaggtact ccatttttga ttgtatagcc 1150561 aagcttttgg attaatgcag tcatttcgtc atagcagcca tgaatatcgc tgatgatatc 1150621 gtaagccatg cggtctcctc cttaccgatt gttttattta ttatgaagca aagtgttgtg 1150681 agtcatcaca agcttttatg tgcaaattat agaagaagaa tcattttcta aacaggatta 1150741 agaccttatc actttatttt tcatcatcac ccttgttaaa atcgcgttat gttttttaaa 1150801 aatgaggttt tgttctctga gtgagaacta gcataaccct gacttaaaaa ggaggttctg 1150861 attatggcgc atacatctgt cgcatcttta gttgttgtac ttatcgttgc atttttgaca 1150921 cccatccttt tgcatcggtt taaactcagc atcccggttg ttgttgctga aatcattatg 1150981 gggctgataa ttgggaaaag cggccttaat ttagttgtgg agggtgacac ctggctccag 1151041 acactctcta tgctcggatt tatcttttta atgtttttaa gcgggcttga aattgatttt 1151101 tcgtcgtttg agaaaggaaa gaaaaagcag ttcctgccga atggcaagga agcgccgaat 1151161 acgtttgctg cggcatctgt tattttcgtc ggtattttta ttttatcatt gctcttgtcc 1151221 tatgggttcg tcttggccgg atttatccaa aatgcatttt tgatgaccct gattatttca 1151281 acgatttcat taggcgttgt cgttccaaca ttaaaagaag aacggatcat gaattcgaat 1151341 atcgggcaga ttattttgct tgttgctgtt attgctgatt tggccacgat gattcttctt 1151401 gctgtttttt cttctttata cggagaggac agcggaaaca tgtggctcct gatgattctg 1151461 tttgcggccg gagtggtgct ttactttttc ggccgggtct tcaaacatcg ctcttttgtt 1151521 caatccatgt caaaagggac gatccagatc gggacgcgtg ccatttttac gttaatcatt 1151581 gtactcgttg ccctgtctga atcacttggg gcggaaaata ttctcggcgc tttcttagcg 1151641 ggggttcttg tttccctgct ttcgccaaac aaagaacttg ttcagcagct ggactcattc 1151701 ggttatgggt tcttaatacc gattttcttc gtgatggtcg gtgtgaagct tgatatttgg 1151761 actcttttcc aggataaaac aattttaatc atgattccgc tcctgctgct tgcgctgtta 1151821 gtcagcaaaa tcattcctgt catgtactta aagaagtggt atgataaccg aaccattttc 1151881 gcgtctggtt tcctgctgac atcaacgctt tcgctcgtga ttgctgctgc aacaatcggc 1151941 cagcagcttc acgtgatcag tacaaatatg tcaggagcgc taattttagt agccgtcatt 1152001 gcaagtattt ttacgccgat ctgttttaaa aaattataca aacgggaaga gcagccggag 1152061 gagaaaaaga cgattacgtt cattggcgcc aatcaaatga ctttgcctgt cacactcgaa 1152121 ttgccagagg aagagtatga cgtgcgtgtt gtacacgtct accaagagaa tgcggaggaa 1152181 aagctgtcag aatcagtgtt tgctgttgaa acaatttctg actatgaaca cgagacgctt 1152241 gaatcactcg gcatttttga aacggatatc ctcgttgtgg cgacaggaaa tgaagatatg 1152301 aatgcagaca ttgcattact tgcaaaagat aaaggcacag aaagagtcat tgcaagcgta 1152361 ggatcaccgg agcatgaagc agctctgaag gagcagggaa tcagcatctt ttctattctg 1152421 ctgtcgacaa aaacgctgct tcgcgcactg attgaagcgc ctggcgtcat gaagctgctc 1152481 acgaaccaag agtcttcgct gtatcaaatt aatatggaga acagtaaata tgatggtgtc 1152541 attttacggg aattcccttt aacaggtgac gtcatctttg tcaggatctt cagaggtgtg 1152601 gacagcatcg ttcctcatgg ggatacgagg ctgaaacttg gagaccgttt aattgtcacc 1152661 ggatctcggg ggtacgtaac ggatcttaag aaaacattgg aaggataaat cttgaccaaa 1152721 taaggattcg tgttaatata gaggtgcaga acaattcaat atgtattcgt ttaaccacta 1152781 ggggtgtcct tcataagggc tgagataaaa gtgtgacttt tagaccctca taacttgaac 1152841 aggttcagac ctgcgtaggg aagtggagcg gtatttgtgt tattttacta tgccaattcc 1152901 aaaccacttt tccttgcggg aaagtggttt ttttattttc agagggggaa tgatttgtga 1152961 agttttcaga agaatgccgc agtgcagccg cagaatggtg ggaggggagc tttgtccatc 1153021 cgttcgttca aggaatcggt gacggaacgc ttccgattga ccgttttaaa tactacgtac 1153081 ttcaggattc ctattattta acgcattttg caaaggtgca gtcatttggt gccgcttatg 1153141 cgaaggatct ttatacaacg gggcggatgg caagccatgc ccaaggtaca tatgaggcgg 1153201 aaatggcgct tcatcgcgag tttgccgagc tgttggaaat cagcgaggaa gagcgtaagg 1153261 cgtttaagcc gtctcctacg gcgtactctt atacatccca tatgtaccgt tcggttttga 1153321 gcgggaattt cgcagaaatc ttagcggccc tgctgccatg ctattggctc tattacgagg 1153381 ttggtgagaa attgctgcat tgtgatccgg ggcatccaat ttatcagaag tggattggca 1153441 catatggcgg tgattggttt agacaacagg tcgaggagca aatcaaccgc tttgatgagc 1153501 tggcggaaaa cagcacggag gaagtgcgtg ccaagatgaa agagaatttt gtcatctcca 1153561 gctactatga atatcaattt tggggaatgg cctatcgaaa agaaggctgg tctgacagcg 1153621 ccataaaaga ggtggaggaa tgtggagctt cacgccataa cggatgacag caagccggta 1153681 gaagagctag cgagaatcat cattacgatt cagaatgaag ttgattttat tcacattcgg 1153741 gaacgctcaa aatcggcggc ggatattttg aaactgctcg atcttatttt tgaaggcggt 1153801 atagataaac gaaaattggt gatgaacggg cgcgtggata ttgcactttt ctctactatt 1153861 caccgcgtgc agctgccaag cggcagcttt tcaccgaagc agatcagagc cagatttcca 1153921 caccttcata tcgggaggtc ggtgcattca ctggaggaag cggttcaagc agaaaaggaa 1153981 gacgcggact acgtgctgtt cggccatgtg tttgaaacgg attgcaaaaa gggtcttgaa 1154041 ggcagaggag tatctttgct gtcagatatc aaacagcgga tttccatccc ggttatagcc 1154101 atcgggggga tgacgccgga caggttaaga gacgtaaaac aagcaggggc agacggcatt 1154161 gctgttatgt caggaatttt ctcttccgct gaacctttgg aagcagccag acgatattcc 1154221 cgcaagctaa aggagatgcg ctatgaaaag gcattatgaa gcagtggtga ttggaggcgg 1154281 aattatcggt tccgcaattg cttattattt ggcaaaggaa aacaaaaaca ccgcattgtt 1154341 tgaaagcgga acaatgggcg gcagaacgac aagtgccgct gccggaatgc tgggcgccca 1154401 tgccgaatgc gaggaacgtg acgcgttttt tgatttcgct atgcacagtc agcgtctgta 1154461 caaaggtctt ggagaagagc tttatgcatt atccggtgtg gatatcaggc agcataacgg 1154521 cggtatgttt aagcttgcat tttctgaaga agatgtgctg cagctgagac agatggacga 1154581 tttggactct gtcagctggt attcaaaaga agaggtgtta gaaaaagagc cgtatgcgtc 1154641 tggtgacatc tttggtgcat cttttattca ggatgatgtg catgtggagc cttattttgt 1154701 ttgcaaggca tatgtgaaag cagcaaaaat gcttggggcg gagatttttg agcatacgcc 1154761 cgtcctgcat gtcgaacgtg acggtgaagc cctgttcatc aagaccccta gcggagacgt 1154821 atgggctaat catgttgtcg ttgccagcgg ggtgtggagc ggaatgtttt ttaaacagct 1154881 tggactgaac aatgcttttc tccctgtaaa aggggagtgc ctgtccgttt ggaatgatga 1154941 tatcccgctg acaaaaacgc tttaccatga tcactgctat atcgtaccga gaaaaagcgg 1155001 aagactggtt gtcggcgcga caatgaagcc gggggactgg agtgaaacac cggatcttgg 1155061 cggattggaa tctgttatga aaaaagcaaa aacgatgctg ccggctatac agaatatgaa 1155121 ggtggatcgt ttttgggcgg gactccgtcc gggaacaaag gatggaaaac cgtacatcgg 1155181 cagacatcct gaggacagcc gtattttatt tgcggctggc catttcagaa acgggatcct 1155241 gcttgctccc gcaacgggcg ctttgatcag tgatctcatc atgaataaag aggtcaacca 1155301 agactggctg cacgcattcc gaattgatcg caaggaggcg gttcagatat gatgctacag 1155361 ctgaacggta aagacgtgaa gtggaaaaaa gacacaggta caattcaaga cctgctggcg 1155421 tcgtatcagc ttgaaaataa aatcgttatc gtggaaagaa ataaagaaat aatcgggaaa 1155481 gaacgctatc acgaggttga gctttgtgat cgtgatgtca ttgaaattgt ccattttgta 1155541 ggaggcggat gagcatgtta acaattggcg gaaaatcatt tcaatcaaga ttgctgctgg 1155601 gcacggggaa atacccatcg tttgacattc aaaaggaagc agtagctgtt tctgagtctg 1155661 atattttaac atttgctgta aggagaatga acatttttga agcatctcag ccgaattttc 1155721 tggaacagct tgatttatcc aaatatacgc ttttgccgaa tacagcgggc gccagtactg 1155781 ctgaagaagc ggttcggatt gcaaggctgg cgaaagcttc aggcctttgt gacatgatta 1155841 aagttgaagt catcggatgc agccgttcct tgctgcctga ccctgttgag acattaaaag 1155901 cgtctgaaca gcttcttgaa gaaggcttta ttgtgctccc gtacacgtcg gatgacgttg 1155961 tgctggcgag aaagctggaa gagctcggcg ttcatgccat catgccgggt gcatctccga 1156021 ttggatcagg acaaggaatc ttaaatcctt tgaatctgtc gtttattatt gaacaggcga 1156081 aagtaccggt catcgtggat gcgggaatcg gctcgcctaa agatgcggca tacgcaatgg 1156141 agcttggagc ggatggcgta ctgctcaata cggctgtatc tggcgctgac gatcccgtga 1156201 aaatggctcg tgccatgaag ctcgcagtgg aagcagggcg cctttcttat gaggcgggcc 1156261 gaatcccgct taagcaatac ggaacggcaa gcagtccggg agaaggtctt cctgtatgac 1156321 aggcaggtat tcaaggcagg agctgtttgc tccgatcggc ccatccggcc agaaaaaatt 1156381 gaaagaagcg cgcgccgtga ttatcggcgc cggcgcgctc ggaacagcca gtgcagaaat 1156441 gctggtgaga gcgggagtcg gctctgtgaa aattgccgac agagattatg ttgaatggag 1156501 caacctccag cgccagcagc tttatacaga agatgatgtc aaaaaagaaa tgccgaaagc 1156561 agccgctgcg gagcgccgtc tccgttcgat taacagcgat gttgatgtga ccggccttgt 1156621 catggatgtg acagcagaaa atatcttcga gctgattagg gatgcatcga ttattgtgga 1156681 tgcggctgat aattttgaaa cccgcctgat cgtaaatgat gctgcggtaa aggaagggat 1156741 tccttttctt tacggtgcct gtgtagggag ctacggtctt acctttaccg tggtgccggg 1156801 ttctactcct tgcctgcatt gcttgctcga tgcacttccg attggcggag caacatgtga 1156861 cacagctggc atcatcagtc cggctgtttt gcaggtagca gtctttcagg taacagatgc 1156921 actgaaactg ctgacgggag aggagtgcga gccggtgctg cgctcctttg atttgtggaa 1156981 aaacgagcgg tcagaagtga gagcggccag tctcaaacat gacgcatgcc caagctgcgg 1157041 cacaaaggat tttccgtttt tgtcttatga aaatcaaaca aaagcggctg tattgtgcgg 1157101 caggaacacg gtgcagatca gatcatctat tacgaaagaa gcggatcttg aagcgcttgc 1157161 cggtcagctg aggcaggccg ggcttgaagt agctgcgaac ccgtatttaa tttcctgccg 1157221 ctcggatgat atgaaaatgg tgctgttccg ggacggcaga gctttgatcc atggaacaaa 1157281 tgatattgcc cgggcaaaat ccatttatca taaatggatt gggtaataaa aggagtgtag 1157341 tgtaatgagt atatataaag cattgacaat cgccggatca gattcaggcg gcggcgcagg 1157401 gatacaggct gatattaaaa cctttcaaga gcttgatgta ttcggaatgt ctgcgattac 1157461 ggcggtaacc gctcaaaata cgcttggcgt tcacggggtg catccgctga ctgtagagac 1157521 gttgagacag caaattgacg ctgttgctga ggatttgaga ccggatgcag ttaagacggg 1157581 aatgctctgg aatgccgaca tgattgaaga agtggcaaga aaaattgacg agtacggatt 1157641 caatcgtgta attgttgatc cggttatgat cgcaaagggc ggggcatcct tgctgcgtga 1157701 tgagtcagtt gccaccttaa aggagttgct cattccaaga agctacgcga ttacgccgaa 1157761 tgtcccggaa gcagaaacgc tgacaggaat gacaatcagc tcgctggatg accggaaaaa 1157821 agcagcggag cagctcgtca agatgggtgc gcagcatgtc attatcaaag gcgggcacca 1157881 gcctgaggac aatcacatta ctgaccttct ttttgatggc agcatgttta tgcaaatcac 1157941 ccatccttat atcaatacga agcatacgca tggcacaggc tgcacctttg ctgcggcttt 1158001 aacggcccaa acggctaaag gagacagcat ccatcaggca tttgaggttg cggccaactt 1158061 tgtccgtgaa gcggtggaaa atacgctcgg catcggatcg ggacacgggc cgacaaacca 1158121 tttcgctttt aaacgaaaca gcttaaatac aagccgatga gatcaccagc tgatggtgat 1158181 ctcttttgcg tttgctacgg tatgcgcttt tcatctggac aaggttatga tatgatagga 1158241 attaagatca ggtactaata ctatgtcttt attaaatata ggaggcttta tacatatgaa 1158301 tttttcactt gaaggccgta acattgttgt gatgggggta gccaacaaac gcagcatcgc 1158361 ctggggcatt gcgcgttctt tacatgaagc gggtgcacgt ttgattttca catacgctgg 1158421 tgaacgcctg gagaaatccg ttcacgagct tgccggaaca ttagaccgca acgattccat 1158481 catcctccct tgcgatgtta caaacgacgc agaaatcgaa acttgcttcg caagcattaa 1158541 ggagcaggtc ggtgtaatcc acggtatcgc gcattgtatc gcgtttgcca acaaagaaga 1158601 gcttgtcggc gagtacttaa acacaaatcg tgacggcttc cttttggctc ataacatcag 1158661 ctcatattct ctgactgctg ttgtcaaagc ggcacgtccg atgatgactg aaggcggaag 1158721 cattgtcact ttgacgtacc ttggcggaga gcttgtgatg ccaaactaca acgtcatggg 1158781 tgtagcaaaa gcttctcttg atgcaagtgt gaaatattta gctgctgact taggaaaaga 1158841 aaatatccgc gtcaacagca tttctgccgg cccgatcaga acattatctg ctaaaggcat 1158901 cagcgatttc aactctatct taaaagacat cgaagagcgt gcaccgcttc gccgcacgac 1158961 aacacctgaa gaagtgggcg atacagctgc gttcttgttc agcgatatgt cccgcgggat 1159021 tacaggtgaa aatcttcacg ttgattctgg tttccatatc actgcccgct aagcaggatc 1159081 tatatcaagc aatcccgaat agggattgct tttttatttc ttctgatttt cagctttctg 1159141 tcatatagat agaatatgac acaatcggag ggatgaagat gtctaataag aaaagaaacg 1159201 cggataaaaa accgctcatg tatattgttc agccggatta tgcagaaact acaaggtcat 1159261 ccatgcagga gattgtcatc aaaagaaagg ccgacaaacc cgctccgcca aaagctgagg 1159321 aaaagccggc ttaccatgag aagcagcagg aggaagccgt ggcacaggat gtcctgcaag 1159381 aagaccaaaa gcctgcagcc gaaccagtga gtcagcaaac acaagaggcg agagagccag 1159441 agaacataaa aagccaagag gaacagaagg cagagccgca ggccgtagaa gaaaccgttg 1159501 aacacgagcc cccgaaagca gaaaaaaagg aagagcctgc acttgaggcc cggaagcctg 1159561 agaaagaacc ggaagctgtc catagtgctg ataaagcgga ggaaaaagca ccgccggcac 1159621 gaaaagtgaa aaaaccgatg agcaagatga cgatccacga aaaaattgat tttttaacaa 1159681 agctgcctca taacatgccg agagcgcttt gtttgattga agccaatgga agaacgtaca 1159741 ggggcgtgat tgtcggaaga agaaatgatt ccgtcctgct tcgaacaacc ggaaacggag 1159801 ccccaaccga actggcaatc gatgatatta cctctttgca cccgctcggt ttttaacgaa 1159861 aaagaaaaaa gctgcccggc tgatgttgcc ggacagcttt ttttacatag agaaaagcct 1159921 gcaggcctgc aagcttttcc agcttatgat taatgatgat gtgtacgatt gattaatcga 1159981 ggatttaagc agttgattgc gcagaagcag tctaagtcaa cttcaataca gtagttcgtt 1160041 ttttcgagtc ggaacacttc acacaccgta tctttatcgg tgaagtccaa aatgtgtttg 1160101 tgttcgtcaa atgcgattaa taatgacagt gttgcacagc ttccatgcac tctttcgacc 1160161 ctgaaaaata ctgtattaaa gcaagggccg ttatcgagtt cgccgacatt tccgaaggcg 1160221 actaatggcg ttgattttga tgtaaatatt gcaaaaggca ctgtgtcgcc taacgaatgg 1160281 cttacagata aaagcttaga gtggcagccg gtcgggcagt cttcttcaac agcgttttgc 1160341 agatcttcaa tattttctac agcttcacgc acgcagcttg atgttttctg gctcatatta 1160401 tccctcctgc cttataaatt tgagactggc gaaatgatgg agagtcagct gcctcacgct 1160461 ggaagcagct gaatgatttg cacctgtaat agagtttgga aggggattcc tctttacaag 1160521 tgtttatcca ttgtgatgat gctttttatc tttgtgaggc gatgttctgt caactagctc 1160581 tggtgacagg cactgaatcg cgcagaagca tccgagatcc acttcaatgc agaaatctgt 1160641 tttttctagc ccgaagaaat ccgggtcgca agggtggcaa acacttaagg tatcgccttt 1160701 gacatcgacc gggcgtaaaa tagacagtgt tgcacagcaa tcgcataatt tttcgacgcg 1160761 gaagaaaatg gattcaaagc attgcatatc atccacaaat ccccctacgt ttccgaatgt 1160821 ggagaacaat ccgccttttt tatcaaaaac gagaaacgga attgtgtctt ttccagcaat 1160881 cgtagggttt aaaaggttgg tatagcagcc agtcggacac tgttcttcaa ctgcctcctg 1160941 ctctgctaaa atcttttcca ctgcatcgca tacacagttc tcatgccggc catgggtttt 1161001 tccgcagctc attgatttca gctccttctt tatagggtat ttgactttag tccttaacaa 1161061 catatgtacc cgtgccccac ttggtgtggg tgaacgtcta tatattcatc atatgcttgg 1161121 aaaataagaa aaagcagagc gtttttagct ctgcttttag gtcctagagg acaagagtga 1161181 taactaggat ggctacgagt gtatttgttg ctgtagaaat aagggttgcg atatcggcat 1161241 ctactgttgt gacgtttacg ccgcgggaac attcgatgag aagtttttgg cggtttactt 1161301 gtttgttagc tgtaagctgt aacaaatctt gtgcgactaa ttcggcaatt acgccgtctg 1161361 caattgatgt cagagttgcc gttacgacag cggcattaag tgctgttaca actgatgtta 1161421 cggcttgaac gtctgtagat gtaacattga tgtcacaaga atctctaata ataatcgttt 1161481 catctgaaac ttgtttgttg agatttgctt gagctagatc ttggtcgatg aaggcgttgt 1161541 cgttgccaaa aaaaccattg ccattacagc aaacgtcgca atgacatttt ctttcgtgtt 1161601 tttctttatc tttctctttg tcatctaacg gatggtcaca gtcaggatca agtgcaaccc 1161661 aagaatatgg tctgctttcc atatctattc ctccttttct tttactgtta ttaaatgagc 1161721 gagcctctta ttttgactga gtcatatatc ctgatgaaga accctatttt ttatgattgg 1161781 ctaattgtta tcgtttttcc gtctttgtct gatctgttca atgagctgct ctctgcggct 1161841 taacggtttt gtgttctttt gctcttgtgc ggctgcttct tcttttttct tcttttggtt 1161901 ttctattagc gcttgtgatt tagcttgtaa gtcttttaca agatttaaga gcatttcttt 1161961 ttcttcgtct gatacttttt tcattttgtc ttttgtgacc ccatgtttag aaaatatatt 1162021 ttggaccagc attttcgtca ttggatcaac ttctggaagc tttgcaagct cttctttgaa 1162081 tttatcgtta tctgacattt gttttcacct cgtcttttaa gtttgtgaaa agaaagggtt 1162141 aaaggacgtc aagttcacta agaatgctgt ttaacacctg aagcaagatt tgtacaaagg 1162201 ttattatctc gtcggcagac aaagtaattt tgatgttgcg gctgttgata attttaatga 1162261 tggttctttt tttgatttgg gagctatcga gaataagaat ttcacttgcc actgcgtcag 1162321 ccaaatcctc gtcggcgatg acgagctgag tcgccacgat aatcatggtt gtcacaaagg 1162381 cttgtataga aagggcagct gttatatgtg acgtgtcaat tgtgatattt tcgcaatcaa 1162441 tcacttcgat ctgctgttcg aattcgcttg ataattgctc aaatattgca gggtgcaggg 1162501 attcgacttt ttcttcaaat gacataacct tcactccttt cttatccata ctctatataa 1162561 tgcaaatggg gtgcagagcg gaataataaa aataaccaat tttctgccgg acaagataca 1162621 attcatgaag aatagggttt tggcatatat gtgaagggat catgattggc aaaggagtga 1162681 acgagtggtt ataaatgggc tgacaattgt tcttctatcg cttgcggtct ttcggctcgc 1162741 ccgcctgctg gtgtttgaca cgattatggc gccgcttcgc agtctgtttc atgaagagaa 1162801 ggaagaaaag gatgcggacg ggaacattga aacctatatc gtgattaagg gaaccggtgt 1162861 cagggcgttt attggtgaat tgctgagctg ctattggtgc acaggcgtgt ggtgtgccgg 1162921 ctttttgatt ttatgccagg cggtgatccc gcaagcggcg cagtggctga ttttactttt 1162981 ggcgatcgcc ggccttgccg gcattataga aacgctcgta tcaaaatggc tgcaagaata 1163041 aggcgttacc accagcaact ttctgtcaga atacgcataa agtagcatat atgacataag 1163101 gaaaggaagg ggacaaaaat gaatcagcat cataaacctt cccaaaaatc tccatataca 1163161 gattcatcgt atcaatcaaa aaagataaaa aagaaaggct gcgggtgcgg aaataaaaag 1163221 aaaaagcctc aatagcctgg caaagaaacc ggagaactcc ggttttttgt ttttttaacg 1163281 aggcggtctc gctcagcata tatcataagc ggggggataa aagtgaatga gtttgaaaaa 1163341 tggatagaag gaagatatga accacatgaa caaaagcaaa aagagcatga agacacgatg 1163401 ggcagtatca gaaaagactt ggatgcattt gataaagccg gtctggaatt tgaagatgag 1163461 attgaagagc tggctgaaaa aacggaggcc ttacttaaaa aacatcaagc tcaatatgat 1163521 caatcgtaaa tccgcaaacg ccctatgcga atatccaagc cgatcccagc agctcacata 1163581 gtgtatagag agtaaaggag gtgcttatct atgggctttg gatacggatt cggcggcggc 1163641 tacggcggcg gctgttatgg cggttatgct ggcggttacg gcggcggcta tggttcaaca 1163701 tttgttttgt tggtcgtatt attcattctc ctcatcatcg taggtgcatc tttcttttaa 1163761 gatgtattga ggaagtacgg gttataaccc gtacttcctt gccttgtgtt tatttttaaa 1163821 aatgttggaa aagcacattg tattatgtgc attcatacaa taccgtatta ctccgccaaa 1163881 aggaggcgca ttatggataa tcaatttttt aagaacatcg aaaagaaaac aggtgtgaag 1163941 atgcaggatg taatgaatct tgccggatca ctccaaaacg ctaattttaa agatgaaaat 1164001 acagtgcgca gtgtgattaa ccgcgtagcg cagatggcaa acagacgcgt gccaaaagaa 1164061 ttagaagata aaattgtgga atctattaca agcggaaaag aaaagcttga ttttggcacg 1164121 atttctaaaa tgatggataa taaataagtg gatggcctgg ctgactcact gcagcgggcc 1164181 tttttttaca gtaaaaaccc ggcagtaatc tgccgggctg ttaatgatgc aagggctgtc 1164241 ttgctttctg tagcagggga tacaaaaatc ttgagcggtt ggctgttttg ccgcgcctgt 1164301 tagcagggca agacaaatat aaatgctgtt tcgcccgggt catggctaca tataaaaggc 1164361 gtctttcctc ctcaagagcg gcctcgtctc cttttcttgc cgtttctaat gagaaatcgt 1164421 gcggaatcga gccatctaca gtgcctaaca cgtagactgt tttgaattca aggccttttg 1164481 accggtgaat ggtcatcagc tgaacgccat gttcatccgt tctgtttttc tcagcggccc 1164541 tcatatggtc tacgtgggca agaaagtcag gaatcgtttt gaacttcttg gcgacaacct 1164601 tgatgtcgcg caggtcatca gagccttttt ccagcttgtt gccctcattg ccccgctttt 1164661 ttaaatactc ggagaagccc atttttcctt ctgcaaaggt gatggcttct acgggtttca 1164721 ttgtgcggag gcttgcaaaa aacggtacga ttttcttgat tttgtccagc tggaatggct 1164781 tcagatcagg caatttggcc agcgctttga tcatggtaca gtcctctgta atcgagagcg 1164841 ccttcagcgt attcaaagcg gactgtttta aaaacaaggc gggaagcaag tgtttaatcg 1164901 cctcggtgtc atcctcattt tggctggcgt acaagtaggc gagaatctgg cggacgatcc 1164961 gtctgctgta aaacgattgg acgccgcggt cagctgtata cggaattgac gattgatgaa 1165021 gcctttcata tatagcacgg cctccgctgt ttgtgcggta aagaaccgca aagtcttctg 1165081 gactggctcc attttgaatt ttttctttga tatcggaaac gaccattgtg gcttcttcct 1165141 cttcatcata aggataaaac agcacaggga cctgaatgtc atcgcgggcc gcttcaagcg 1165201 ttttggcata tctgtttttg ttctttttca caacgatatc agcactagag acgatcgggt 1165261 gcgtagacct gtagttcgca gttaaataga tcgtcttcgc tcccggataa tccttttgaa 1165321 aatcaagaat gaaagacgga ttgcttccgc gaaacgcgta gatggactgg tcatcgtctc 1165381 cgacacagca caggttttgc tccgggctgg cgagcatttg catgattttg tattgaaccg 1165441 gattaatgtc ctgaaactca tcaattaaga tatacgtaaa ccgagattga tattgttcca 1165501 gaaggtcagg ccgctcgata aacaattcat agcaggctga agccatgtca tcaaaatcaa 1165561 attggctgtg ttcttttttc tggcgttcat aatgttcata taaacgataa acttgttttt 1165621 cccactcatc ttttagaggg atgcgttcat ttgggacata agtgtttttc caaaaaccga 1165681 tctgctgcag ggcttggtca actggggatt ctttctcatc gatgccttct tcatagagtg 1165741 cttttttgat atattgttcc cgctgccact ccattttcag cagatgctca ccgttccatt 1165801 tagcagaatt agagtgatac aagatcttat aaaacagact gtggaatgtt cctgtcacaa 1165861 ttcttctgac ttttgccggc tgtaatccgt actggttcgc catacgctct ttcatttcag 1165921 cgacagcttt tgttgtaaag gtgacaagca gcatattttc aggcggtatg cctaagtgtt 1165981 cgatcatgtg ggcggcacgg gctgtcagta cccgtgtttt tccgctcccc gcacctgcaa 1166041 gcacgaggag cgggccctct gtttccgtga cagctttcag ctgatccgtg tttaaaccga 1166101 cagacggaaa aaggctcgta tcgggttcta ttgtttttgg cacaaatggt gttcctggtt 1166161 taatgcttct aggacggtgc cattctgtaa cagctgggga cgggtcagcg gcgatcgctt 1166221 ttcccttggg taaacgaatg acaccagatt cctgatcatc ttcttttttc ccctctttag 1166281 agggcttcgg ttcgcacgcc tcctcacatg ccggaaaatc gcctggctgg cgatggataa 1166341 actctggcgg atcggcgatg ttaagccgta acaaaacggg ctttccgcaa tgagaacaaa 1166401 ataaatgtcc ttttattccc tcttcaaaga ggaattgata atgttctctc gaatatgtat 1166461 gtaaatgtat gattctatca ttcagtcggg cgcatttcaa aaaggggtcc tcccaatcaa 1166521 aaggtgttca ttacagacaa tgactatcat atcaaaagaa atgtgtttca aaaagtaagt 1166581 ttaagggaaa agagacagca gaggggtggg tattgtatga tatatgcagg tcaaattcag 1166641 aaccagcaat acgctcaata tgctaataga acgattggac ataagcagga ttatgccgga 1166701 accgaaaaaa tcagctatgt cccgtttcag cgggtataca aagaactgga aaagcagcag 1166761 gagaatcaaa cggcagctga aagaaaagta aacgagatga aacgtaagcg ctctctttat 1166821 aagagattgc gagaaaaagg aatggggaca tatattaatc gatatgtata aaaaaccgtt 1166881 cataccagag aacggttttt ttatatgcag taaaaatccg gatctcaaaa gatccggatg 1166941 cgttcagtcc ttcatcattt gtaagtgcgg aatgccggca tcgaggaatt ctttttcaga 1167001 aagcacgcga tacccgtgtt tcttgtaaaa cggcacagcc tgtgtttgcg cgtttaaaat 1167061 gaaaccggaa gcgcctccgt ctgccgcggc tttttcgagc gctttcataa tgatgccgcc 1167121 gacaccggct gagcggtggc ttttcagtac gcaaatccgc tctaacttgc cgtagccgtc 1167181 cttcatgcgc catcttccgg caccgacagg cttttcaccg tcatacacga cgatatgctc 1167241 tgactcattt tcaagttcgt caatttcttc ttcagcaggc acgttttgtt ctttgacaaa 1167301 gacttcttct cttacataga atgcatcttt cagttgttct tcattttttg cgataactgc 1167361 tttcaaacat tattctcctc tgcctagcaa gaaggtttca tatactgtcc acgatccgtt 1167421 ttccaactgg tagagcaagt ggaaacggtc aacgatttct tcatgcgaca cttcctgcat 1167481 ttttaattgt cccagcacat ctgaatgctc atcgtcggaa agattttggc cgaccgtcac 1167541 atgcggaacg aaattatatt cctgttctcc tgccaacaca ccggtgtata gcttttcatt 1167601 gagtgttttt aactcttccg tcggttctgc tttgatgtaa atgacattat tgacaggcgc 1167661 aaatgagctg tattttgtca ttttgagaac gagtgggtgg gactcttttg cgatgtttct 1167721 taaatgtgat acgagctgat ccgctttctc ctccgcgcat tcaaaggatg ctctcagcgt 1167781 caaatgaggc gggattagag agtagcttgg gtcatagcgc tttctgtaag agtttgcaag 1167841 gtcttggagc ttttttgatg gaaataaaac gattccgtat ttcatattat gtccctcctg 1167901 gaaataaagt atgatagagt gttaaagcat ttttttcagc gccggggtga tgagcggctg 1167961 ccagtatgtc catttgtggt ctccgtcaaa tggctcgaaa tcataatcgg aaagcttttt 1168021 ctccagcagc tgtttcagct cccggttcgg ttctgtaaag tccagaatgt tcccgtctgt 1168081 cgtgtggacg tcagtttctt ttgttccgat ttggtgataa atagagaggt gtttgatatc 1168141 gtctgactgt tttacggctt ctagtacgtg tttgtcaaca tagggagact gcatgatgat 1168201 gttgccaaac atattcggat aatcaagcgc tgtcataagt gacacggttg ctccgagcga 1168261 atcaccgatc agcgttcggc cgtaaccgat ctgataggtt ggatactcat catctgcaaa 1168321 aggaacgagc tcatgggcga tgaaccgttt ataagccgaa aattttgaac cctccggatg 1168381 ataagtgttt ctgcgctctt ttacatcctt atagggaaca ccgataataa tgctccggtc 1168441 tatttcgcgt ttcgacagca attcctcaac ctgtctgccg attctcccca gcctgaaata 1168501 atcgtggccg tcctgcgcga taatgacatg gtatttataa agcggggagt agttggacgg 1168561 cagataaaca agcaaggtca tttcctcgtt aagctctttt gaaaagaatt tcttttcttg 1168621 cactgtgccg tttttcggtg ccataaaaac attcctccag gacatcacta tactttcttg 1168681 cattttcaat tattgtacca tgaattatta gaaatttctc tctttaaacg gttcggcaca 1168741 cgaagaaaaa agtgttgaaa taaactgtga attgcgctaa tataaaacaa tcagaaaatt 1168801 gaaatcgata tttcttatcg tgagaggtgg agggactggc ccttagaaac ctcagcaacc 1168861 ggcttgtttt gcatttgcaa agcgccaagg tgctaaatcc agcaagcgtt ttttatgctt 1168921 ggaagataag aagaagcgtt aaaccccttc ttcttatgaa gaaggggttt ttattttgaa 1168981 aagggaaggt gtcagctata tgtcacagca cgttgaaacg aaattagctc aaattgggaa 1169041 ccgtagcgat gaagtcacgg gaacagtgag tgctcctatc tatttatcaa cagcataccg 1169101 ccacagaggg atcggagaat ctaccggatt tgattatgtc cgcacaaaaa atccgacacg 1169161 ccagcttgtt gaggacgcga tcgctaactt agaaaacggc gcgagagggc ttgcctttag 1169221 ttcgggaatg gctgctatcc aaacgattat ggcgctgttt aaaagcggag atgaactgat 1169281 cgtttcatcg gacctatatg gcggcacgta ccgtttattt gaaaatgaat ggaaaaaata 1169341 cggattgact tttcattatg atgatttcag cgatgaggac tgtttacgct ctaagattac 1169401 gccgaataca aaagcggtgt ttgtggaaac gccgacaaac cccctcatgc aggaggcgga 1169461 cattgaacat attgcccgga ttacaaagga gcacggtctt ctgctgatcg tagataatac 1169521 attttataca ccggtcttgc agcggccgct tgagctggga gctgacattg tcattcacag 1169581 cgcaaccaag tatttaggcg ggcataacga tctgcttgct ggacttgtcg tggtgaagga 1169641 tgagcggctc ggagaggaaa tgtttcagca tcaaaatgca atcggcgccg tcctgccgcc 1169701 atttgattcg tggcttctga tgagaggaat gaagacgctg agcctcagaa tgcgccagca 1169761 tcaggcaaac gcgcaggagc ttgcggcgtt tttagaagag caggaagaaa tttcggatgt 1169821 gctgtatccc ggaaaaggcg gcatgctgtc cttccgtctg caaaaagaag aatgggtcaa 1169881 tccgttttta aaagcactga agaccatttg ttttgcagaa agcctcggcg gggtggaaag 1169941 ctttattaca taccctgcga cccagacgca catggatatt cctgaagaga tccgcatcgc 1170001 aaacggggtg tgcaatcggt tgctgcgctt ttctgtcggt attgaacatg cggaagattt 1170061 aaaagaggat ctaaaacagg cattatgtca ggtcaaagag ggagctgttt catttgagta 1170121 aacacaattg gacgctggaa acccagctcg tgcacaatcc atttaaaaca gacggcggaa 1170181 ccggggcagt cagtgtaccg attcagcacg cctcgacttt tcaccaatct tcatttgaag 1170241 agttcggggc atatgattac agccgctctg gcacgccgac aagaacagct ctcgaagaaa 1170301 caattgccgc actggaaggc ggaacaagag gatttgcttt cagttcaggc atggctgcca 1170361 tctcaacagc atttttactg ctgtcacagg gtgatcacgt tcttgtgaca gaagatgtat 1170421 acggcggaac cttccgtatg gtgacagagg tgctgacccg gtttggcatt gagcatacgt 1170481 ttgtcgacat gacggatcgt aatgaagtgg cgcggagcat caagccgaac acaaaggtca 1170541 tttatatgga gacgccatca aatccgacac ttgggattac ggatattaaa gcagttgttc 1170601 agcttgcaaa agaaaacggc tgcctgacct ttctggacaa tacattcatg acgccggcac 1170661 tgcagcgtcc gcttgatctc ggcgtggata ttgtacttca cagcgcgaca aaattcttaa 1170721 gcggacacag cgatgtgctc tcaggtttgg ctgctgtcaa agatgaagag cttgggaagc 1170781 agctgtataa gctacaaaac gcgttcggcg ccgtccttgg cgtgcaagat tgctggcttg 1170841 tcctgcgcgg attaaaaaca ttgcaggtcc gtttagagaa agcgagtcaa acagctcagc 1170901 ggcttgcgga atttttccag aagcacccgg cggtcaagcg cgtgtattat ccgggactgg 1170961 ctgatcatcc cggcgctgaa acccataaaa gccagtcaac gggagcgggc gccgtgctat 1171021 cttttgagct tgaaagcaaa gaggccgtta agaagttagt cgagaatgtg tcactcccag 1171081 tcttcgctgt cagccttggc gccgtggaat cgattttgtc ctatccggca acgatgtctc 1171141 atgcggcaat gcctaaggaa gagcgtgaaa aacgcggtat cactgatggc ctgctccgtc 1171201 tgagtgtcgg cgtcgaacat gcagacgatt tagaacacga tttcgaacaa gcgctgaaag 1171261 aaattgctcc agtttcggtt cgttaaaaaa gaagccgggg atagtccggc ttcttttatt 1171321 attgttcgtc atcaggattc agaatcgcga ggacttgatg atcctcccaa acgccattaa 1171381 tttttacatt ttttcgggcg atgccttctt tatgaaatcc cgctttttct aaaacacgca 1171441 tggacccgag attacggggc atcacaccgg cttcaatccg atgcagtttc aattcgtgga 1171501 acgcataatc aacaaccaat ctgactgcct ctgtcataat gccctttcca ttatgggctt 1171561 tgtctaaaaa atacccgatg aacgcagttt gcagcgcgcc acggatgatt tgaaagagcg 1171621 aaaccgtccc gattaatcta tcgtctgacg ctgtaaagat gccaaaatga tattcttcat 1171681 ctttctcaag tctttcctga tactcggtta ttcgttttct ttgcccctca accgtatagt 1171741 aatcgtctgc gcgtatcata gaaaactgtt cgaaaaaatc tcgattttcg ctttgcagcc 1171801 ccagattttc ttcggcatcc gttacttcta aaggtctaac ataaatggtt tttcctttta 1171861 acatatagtg atctctccgt tctcatgtca gcattcctct tacattattc tcagggaaat 1171921 gcaaatatcc tttttataag aaggaagaaa accaatttcc cataaaagtg ccaacatagt 1171981 tgccgattaa gtagccgagc gtaccgacaa gcatgatcgg ggcgacaagc tcccgccatc 1172041 ccttggcaat tgccatcgca gccgcagtcg tcggtccccc gacagtagcg ttgacggcga 1172101 gcagaatttc ttcaagccgc acacggaaca attttccggc agctaaggaa accgctaaat 1172161 tgctaatcgc aatgataaac acgaataata gaataagagg cgcattcgtg acgattaagc 1172221 ggagatctgc aggaatgccg atcaccacaa aaaacaaata aatcaaaaag gttccaagct 1172281 cctgagatcc attgagcctt tcaaaaaaac gcgggaaaag aaaaatgata agaacagtta 1172341 aagacgtaag aaccaggtac tgatcgccaa gcgtaccggt cagcagggga tgagaaaaaa 1172401 tgcttttaaa ataaccggaa accttcatac taaccgcaac aagcgcgaaa gcggcaccgg 1172461 cattaaaagc gatatccttt aaggaaatat ccttccgttt ccaatagctt tcagcactgt 1172521 ttccgctgtt tccatcggct tttaccttct cttcaaacgg catggcataa tgccgctgaa 1172581 accatttgag tgcaggaatg ctgattaaaa taaaaaacaa aagcgccatc ataaaattat 1172641 cagccacaac ggtagccgac acatattcac caggcgtctc aaattttgcc gccatcgccg 1172701 caaagttgac cccgccgccg atataagagg cgctgatcat cccaccgatt ttatctaagt 1172761 aaggaatatg ctgtttgagt agaaaaaaag ccaggatact gccaagcact gttccaacgg 1172821 agctaatcag aaaaataaac agcaaacgcc tgctttcctt aaaaatttgc ctaacattga 1172881 tctgaaacaa taaaagtggt atcgccagcg gtaccacata agaccacaca gtgtcataca 1172941 cgggcgactc aacaggaagc actcctacat ttgtaaacac catagcacct gcaagggcga 1173001 taatagcgcc cgacacagca gacgcccact taaagcgctg ctccagcccg atgctcactg 1173061 ccgcccacac cgcaataaac ccccataata cccatacatc atcagaagaa atcaaagaat 1173121 gcaaaacccc atcacctcta ttgttagaaa attaagacat attataatag ccggggaacg 1173181 gaacagcaag tccaaaaaaa gtttttctaa aaaagcagtt gacgaataga aggtaaggtt 1173241 atataataga acttgtcaga aagataacaa catacccagc aacacataca tatcatgatt 1173301 ccgtagctca gctgggagag cgctaccttg acagggtaga ggtcgctggt tcgagcccag 1173361 tcggaatcat agcttaaacc cttgcgcagc aagggttttt tactttgcgt taataaagcc 1173421 ggttcgtcaa attcgtgagt tgttggcgaa ctgttggcga aattcattga ccgcagtcca 1173481 aaaactacct ccaaacttac ttgattagtt caatagtaac aaacggaaga tcggatttct 1173541 gttaaatctt cattgagaat agccagtcca agaccgtcac ttcagccatg catcttttaa 1173601 atgaaatttt gtactgaaaa catcaattgt atttttaaat tctgctctag aatcagcccc 1173661 tttataataa tcttgataaa ttgcttgggg tgatactgat tcgtgatttg tgctatggtt 1173721 tgcaaggctt gtagcaaaag caggagcaac agtaacgagt aaagcaaggg ataatgcaaa 1173781 accagttaaa gctttttcaa tttcatttta agcacttctt tttttaaaat acaactttat 1173841 tattaaatgg aatacaaaaa catccaaggt gtttttttgt tagtaagttg agttaggggg 1173901 attggatggc acttagaata ttgtttctgc tgatgggatg ttgattctgg atatatttcc 1173961 aacacgatta caggccggac atgaaagcga accttgcttt gatcggggca atcatttcat 1174021 ttacggctgc ggtttacttt aaagatattg atgtattgag agaagaggga aaacaaatga 1174081 acggaatttc tgagcgttgg aacacgttta aattacaaaa atcccctgaa ccactctaga 1174141 tcaggggatt gctttcccaa cagcttatta agtagcggaa ggcatgatca acgatttagt 1174201 atcaatttat taattgcgaa tactagaaac ataccgtttt ccgccttcct tagaagtaac 1174261 atattctcga ggaacattaa gtctattggt agaatgataa cttacataaa gtttcatatt 1174321 tgctcggctc gttacgatag ccgtatgatc catccaacca tcagcatagc gaagacctat 1174381 tttattatgg taatcatagt gatatacatc tccaagcttt acatttgaat atgtatcaga 1174441 aacagtcttc atttttattc cgccagcttt taaaatgtat gatctaaagg ctcctgcatt 1174501 aacccaagca tctgtatagg gtttccattc tttaaagtac ggcattcttc cagctcttaa 1174561 tgcttgggaa acaaagttag tacaatcttt gtctttataa tatttatagt ttttatttgg 1174621 ttttaaggca tatttttctg catatttcat tgcagcgtaa ccactatatc ctttaacaga 1174681 tgttgcagtc acagttagtt gattagagtt agcagcattg aagttcatac ttactggttt 1174741 atcttcactt ttcacttctt ctttatcatc atttttcact tcttgcttat atttttttaa 1174801 aaattcatct aatttaacat ccgaagaata ttcttcatca ttttcatatt gtagagttga 1174861 agaagaatta tttaattgtg ttacatttag ttgcttagaa gaattactca atggtattac 1174921 atttagttga ttagaagaat ttttaacttg agagaaactt agattagaag tatttgttga 1174981 ttgagaactt tgtttattag aagttgtttt gggaatttca agtttaatat tatcgcccag 1175041 agatgttgtt actttttcaa caccaaaaac aaagtttcga gtaatataag cttcaacaat 1175101 tagcttattg tttttttcag aagtcttaac atcgtctata tcgtatgtaa actcgtggaa 1175161 tttttgtttg tccactttac ttaacgcaga atacagtaag actccttcgt cggaatcagt 1175221 caatttagac tctttaggat gcgctaaagg agtgttgtgt tcaaaatcat atttttgttg 1175281 ttctaacata tccttaactt tttcgtaacc aatctcgttg gtaattgaaa cattttcttt 1175341 agtctcttta ttagtagtgg ctgcaaaaac ttcatttgtt gacactaatg gtgacaatga 1175401 tagacataaa actagtgaag caagtaattc ttttttcata cgaaacctcc aataaaatct 1175461 aaatataagt aatatttatc atttacacca attgaaatat ggcataaaat acatgtaata 1175521 atataacata aaaataaata cataaaaagg tatcggagga aaaaatgaaa aagaaaacta 1175581 aaattatact ttctctcttg gcagcactta ttgttatatt gatagtactt ccagttctat 1175641 ctcctgttgt ctttacagct tcttcggaaa aaggagcaat cagacacgaa atttataaaa 1175701 gaggatatcc ctaccaaagc tactttgcag ttctccagaa aagagaagga gacaatgaat 1175761 ctgggaatct ttattatgta aattggctag attggaaaga tgaaacaggg caaactcctc 1175821 acttatgcta ttcgaaaaaa tcatcagatg gtgaatacga agtaagttgt ggcacagggc 1175881 cgtaaaaata aattttaaaa ttgaataagt ccaagacgga aagcctgcgg acactgatcg 1175941 ttttacagag aaatttgtgc ttcgatcggt gtccgttttt tttcgcaact aaccagatgt 1176001 ctatcgcgat tactagctat gaaaggagta attagacatg aaacagtcca aaaagaaacc 1176061 atcacagaag caacatgagc gcttagatcg tttctggcaa caaatgatga acactaacat 1176121 gcaaacactc agacgtggca aaggcggcgc ttataaacgc agaaagtaaa aagggagttt 1176181 gaggatgatg aaaaacggat tcgcttataa aaacggaaag cttgtgaata tcttttgcgg 1176241 caaagaagag ctctataacg agttgaaagc cttcttggtc aaaaccttca gtatcaacgt 1176301 gaaagaggta tcgaggccct caatatatcg cagaacaaaa agcaaacaac tggaatgaca 1176361 cttactctat ttaactatca ggagggaaag cactatgaca gatcaaatga ttgcatggga 1176421 gattgaggaa tggattcgtg attataaatt catgctgcgg gagatcaaaa ggctcaaccg 1176481 tgtattaaac aaagtggatt ttattagcac aaagctcact gcaacatacg gggaggaagc 1176541 gggcatgcca aggggatcag caggcgtcag tcaggcagaa ttgcggcaga tggaccgaag 1176601 agaaaggcgg cttcacaaat atgaatctat tgtgcattac ctggacaatg caatggaaca 1176661 cattgaagaa gaaaagcacc gaatcgttta cgattgcatg atggaaggca tgagctacac 1176721 tgctattgca aaccaccttg attgctcccg ggataccatc agaaagatca aaacagccat 1176781 aatcggcaac atcgtcaata aagtcaaaga agccaacttt ctgcaatatt tgaattcgtt 1176841 taaatcggcg gtgtaaaatg gggggcagga tcggcgcggc ggattattcc tgcgtcacca 1176901 ccaatttcat acaatgagta aaacctccca gtggtaagcg aggatcaact caactgggag 1176961 gtcttacata gtgaatcggt gataaaacag cagcagtatt gcgtacatgt taatatcccc 1177021 gacaaaatat gtttttttca acagattcgt tcgacaaatt ttgcaaattg ttaatcgata 1177081 acttttcatt cccgatatta aaaatgggag tgaattgtaa aatgaaaaaa cagaaaaata 1177141 ataaaaagaa gaatattgaa aagcgaaata ttgaaaagcg aaatattgaa gagaagaata 1177201 atgaggactt agaagaactg gaaaatgcga tttatactta tcacaaaaag gagctacttg 1177261 ctttctttct tgaaaaaact cgaattggtc atgataagga agaatacaaa aggttccaat 1177321 ctcttcttta taagttggat attgaatgtt tagaatttgc tatatcgaga ttttctcata 1177381 tagatattat ccatgatcat tcaaaatatg ttccagcctt tatcccttta tttgcagcat 1177441 atctcaccat gttctttaat ttttatgaaa aacattgggg agctttatct tttgctgctg 1177501 gtacaattgc tgctattgtt tggataattg cagtagaaag aaaacataga aatcaagcaa 1177561 tttctattat gaaaatattt gaacaagtca aagagagaaa agtgaaagac agatctaaag 1177621 actgaaagga gaaaatatga ataaggataa attaaggtat gcaatcttaa aagaaatttt 1177681 tgaaggtaat acccctttgt cagaaaacga tattggagtt actgaagatc aatttgatga 1177741 tgctgtgaac tttttaaaac gcgaagggta tatcattggg gtccattatt cagatgatag 1177801 acctcattta tacaaattag gacctgaact gacagagaaa ggtgaaaact acttgaaaga 1177861 gaatggaaca tggtctaagg cctataagac cattaaagag attaaagatt ggattaaata 1177921 ataagagcat cctgcggggt gctttttttg ttccctgtaa actgcttccg gtaagtctca 1177981 ggatagacaa ttggcggtta acggcttgag cacggtggtg gtttagaggg aatatctttt 1178041 ccaaaacaac acgaatcaga agggggcggc ggtgaatgta gatggccgaa aagcacattc 1178101 aggcgtataa ggattacgtc aaaggcatga aatacaagga ccttgccgag aaatacgggg 1178161 tgtcagtgaa caccattaaa tcgtggaagc agcggcatgg ttgggaaagg aaaaagggtg 1178221 cacccattga aaaaagtgtg cacacaaaaa aaggcgggca accgggcaac aaaaatgcat 1178281 tagggaacaa tggcggcgca ccacagaaga atcaaaatgc tgtgactcac ggctttttct 1178341 ctaaattctt gccagaagag acgcttgaaa tcatggaaga gattcaggag cgttcgccag 1178401 ctgatatgat atgggatcag atacagattc aatatgcggc cattcttcgg gcgcaaaaga 1178461 tcatgttcgt ttctgataag gaagaaatga tcaaagagct gaaaaagaaa aggtccctca 1178521 tatctgaggt cagcgaaatt gaagatgggc ttgtcattag ttttagtacg tggtttcgct 1178581 acagacttta cagtgaaaca aacacctaac acatttcaca ttgcttcaga ttgccttcaa 1178641 acttgataat ataacttcta aaccttccta taaaatgaag gttttttatt tgatttcaat 1178701 ttttaaatcc tttacataca gcgattgatt aactcgagca atcaatgtcg cagttatatt 1178761 tatttttcaa gaaaatgtta taatgaaaag ccataaaatg atgggagggg gaatttcgat 1178821 gcattacata acggcatgtt taaaaatcat cagtgataaa gaccttaatg agataatgaa 1178881 ggaattcaaa aaacttgagg aagaaacgaa caaagaagag ggttgtatta cattccatgc 1178941 ttatccgctt gagccatcag aacgtaaaat aatgctttgg gagatttggg aaaacgaaga 1179001 agctgtgaaa atccatttca caaaaaaaca cacaatagac gttcaaaaac aagaattaac 1179061 ggaagtagaa tggttaatga aaagcaatgt gaatgattga aaggctcttt aaaaagagac 1179121 attcaatgac ttagtatcag ccacttgtga ctaagtagta aattgttgtc caactcttat 1179181 tttttctatt taatattttt tgagacgaaa atgttttttt aagctgattt taaaatgtat 1179241 tcaaagtcag ctctgtttga tttaatggat tatattattt ggatagcttg ttaccatcat 1179301 aatggagata ctccttataa attggaggtt aaaataatga gtcattctca agaaaaaatt 1179361 gcactaatta caggagcaag cagtcaaggg gatattggta cggctatttg tcgtaagtta 1179421 gcctcacagg gtatacatat cttctttact cactggaatt ctgatacggc ctggatagaa 1179481 gaatttcaac aagaaatttt acgtatgggt gtccgctgtg aggcaatgaa aattgattta 1179541 tcagatgcac atgctgcatt cacaatacat gaaaaaattt cagataaatt aggatatcct 1179601 tccatcctta ttaataatgc agctcattcc gcaagtgata attatgtatc gttagatgct 1179661 aaatcacttg atgagcatta tgcggttaat atgagatcga attttcttct ttgtgttgaa 1179721 ttcgcccgtc ggtttaaaaa atctaattta atatcaggaa gaatcatcaa tatgacatca 1179781 gggcaggatt taggtccttt gcctggggag ttagcgtatg cagcaactaa aggagctatt 1179841 tctgcattta ctaggtcgtt atcacaagaa cttgcaccat tgggcatcac tgttaacgcc 1179901 gtaaacccag gtccaacaga ttctacatgg atgacagatg aaataagaaa ttttctttca 1179961 cctaaatttc caatggggcg tattggcaca ccagatgatg cagcacgaat gattgccttt 1180021 cttgcaagtg atgaggctga atggataact ggacaaatta ttcattcaga aggtggattt 1180081 attcggggct aagctaatga aacacggtat acaccaatgt atgatgtatt cccaaaacta 1180141 aatctaaact tgaagcgaaa ataaggtccc ttctcttttt agagggggac cttattttat 1180201 tcatgcatgt tttgcatcca gaaaatctgg cggataaaga ttaataaacc gttacatata 1180261 cttttccgaa tactgcagta cctttaaaca aagtaatcgt ggctttccct tttgatttag 1180321 ccgtcactaa accattttga tcgacttcag caactttttg gttatcagtc caataacgag 1180381 tagctgaatt atttttaaca gaataggttt ctccaacttt tagaggtaaa ttatagtctt 1180441 gaatcttgat aacatgtgta ggtgaaatag aaatgttctt tacttcagta ggtgtggagt 1180501 ttatttcatg agctgaagct accccgctga ccgacagagc taacgcagaa atcgataaag 1180561 cagaaacaac cgtttttttg aaattcattt tgaaacactc ctttaaagtt ttttgtcttg 1180621 cactataaca attcaataaa agtaattatt ttccttgtaa ataaatgtta ataatatgtg 1180681 aacgatcaat tgatttgagc taagaatatt gtgtgccctg cacagagttt gtatttatga 1180741 tggaaaattg ctgagagaga atggccatcc ttaaaatgtt aatagcacac atttgatggg 1180801 tattagtttg ttgagcgtgt ggaaattttg ttacctgcac tttatccccg aagataccaa 1180861 atcacttttc ttcatcatgt tcttactttc gtactcatac attagaaaat cttcgttcta 1180921 aataggtgaa gaattggagt atttttatga atttctgctg aatatacatt acatagcaaa 1180981 ctcaaagagt ataaaaatcg cttttttccg gaagcttcgg taaaaaacga aacttttgtc 1181041 tctatgattt tgttttataa tgtaaacggt ttcttatata gtatacttat actatcaatt 1181101 tgctcaagta gatactgaca ggaaggatag aaaaacagat ggaatacata aatacaagac 1181161 aaaaagagat tttgtatctg ttgttatctg aacctgatga ctatttagtt gtgcaagatt 1181221 tcgcagatag ggtacagtgt tctgaaaaaa caatccggaa tgatttgaaa gtgatcgagg 1181281 attatctcaa tgagcattct catgcacagc ttattcgaaa accagggttg ggcgtttatt 1181341 tacatataga agaacaggaa aggacctggc taagccaaca attacatact gaacattttt 1181401 cttctaggca gcggagcgat aaggaaagaa tgctgcacat tgcttatgac ttattaatga 1181461 atccgaagcc tgtttccgca aaagacattg ccgctcggca ttttgtcaat cgatcttcca 1181521 ttaaaaagga tttatacgca gtagaagagt ggctgaagcg ttttgatctc acactggttt 1181581 ctaggcagcg gcttggatta aaggttgaag ggaacgaaag aaataaaaga aaggcattgg 1181641 caagaatatc tgatttgatt cacaatacag cgtttaccag ccaatttatt aaaagtaagt 1181701 ttttacatta tgaagtagac tttgtgacga aagaaatcaa atcactacaa aaaaagcatt 1181761 ccctctattt cacagacgaa acgtttgaaa gtttgttgct gcatacattg ttaatggtcc 1181821 gccgcatcaa aatgaagcag ccgatttcat tgtccccaaa agaaatggcg gcagtaaaaa 1181881 agaagaaaga atatcaatgg acatttgctt gtttacagcg gcttgaaccg gtttttgcaa 1181941 ttcgcttccc tgaagaagaa gccgtgtact taacattaca tatattgggc ggtaaggttc 1182001 gttatccatt gcagacagaa gagaaccttg aaaatgctgt gcttcctaag gttgtagggc 1182061 atttaatcaa tcgtgtttca gagctgaaaa tgatggattt tcacaaggat caggatttga 1182121 tcaatggttt gaacattcat ctcaatactg tgctacaacg gctgagctac gatctttctg 1182181 tagcaaatcc tatgctcaat gacatcaaaa agatgtaccc ttatttgttc cacctcatca 1182241 ttgatgtttt ggaagacatc aatcaaactt ttgatcttca tattcctgag gaagaggcag 1182301 catatttgac attgcatttt caggcagcga tcgaacggat gcagggcagc agcgagacac 1182361 ataaaaaggc ggttatcgtc tgccacatgg ggattgggat gtcacaattg ctgcggacaa 1182421 aaattgaacg gaaatatcac caaatcgctg taatggcttg tattgcaaag gccgatttaa 1182481 aggattatat caaaaagcat gaggatattg atcttgtcat atccaccatt gcgctggaga 1182541 atataacggt tccccatatt gttgtgtctc cgcttttaga gcctggcgaa gagaagaaat 1182601 taagtgcgtt tatacgtcag ctgggcgaat cacaccgcca aaaacaaaaa acgtttcaga 1182661 tgctgaacaa tacgactcct tttttggttt ttttgcagca ggaggcggag catcgctaca 1182721 agttaatcga acagctggcg acagctttgt ttgagaaagg ctatgttgat aaggactatg 1182781 cggttcatgc ggtgatgagg gaaaaaatgt cggctacaaa tattgggtca ggcattgcca 1182841 ttcctcatgc aaacgctaaa tttattaaac aatcagcaat cgcgattgcc acattaaagg 1182901 agccgcttga atggggaaat gaaaaagttt cgctcgtttt tatgctggct gtcaaacacg 1182961 aggatcaaac tatgacaaag cagctgttta gcgagctttc atatcttagc gagcagccgg 1183021 ccttcgtcca gaagctgacg aaagaaacca atgtcatgac atttttatct catttggatt 1183081 attaaaagca gggattattc cttgcttttt ttgttcatgg cagggcttga gaaataaatt 1183141 tgcgagtgaa gacgcctatt ctccagcaat gatctaaata aaataagagt ttaatagttg 1183201 gagaagaaat gttacactct tttctgtata tggtaaagaa tgaaaaaaca cgattcggtt 1183261 ggtagtccgg atgcatgatt gagaatgtca gtaaccttcc cctcctcggg atgtccatca 1183321 ttctttaata tcttttatga ggagggaatc gttatgaaat taacgattta ctacgatggt 1183381 cagttttggg taggcgttgt tgaagttgtg gacaatggaa agctaagagc ctttcgtcat 1183441 ctttttggca aagagccgag ggattctgaa gtattagagt ttgttcataa ccaacttttg 1183501 aatatgatgg cccaagctga gcaggaagga gtgcgtttac aaggcaggcg tcaaaaaaag 1183561 atcaatccaa aaagattgca gcgccaggtt tcaaaagagt tgaaaaacgc cggagtaact 1183621 tctaaagctc aagaggcgat aaagctagag cttgaagcaa gaaagcaaaa gaaaaaacaa 1183681 ataatgaaag aacaacgaga acatgtaaaa gagcaaaggt atatgctcaa aaagcaaaaa 1183741 gcgaaaaaga agcacagagg taaataatcc aaacaaaagc aggcgcagtg cctgcttttg 1183801 taattaagga ctctactttg taacatatat ccaatgttta tactccgctg atttatgatt 1183861 caatataaac cctaacttct ccaaggtttt ttgtgagcct agattatcat gttcgcatct 1183921 tgcggtgatc cgggatactg tttctcggct taatgcccag tttattagtt tttgggcggc 1183981 ttccacacaa taacctttgc ggcgatgact tttatttgtt gcaaaaccga tttcaatcat 1184041 gccattttcg tctgggtcac ctaaaaatcc agttccccca acaatttcat aattgtcctt 1184101 ctttacaata atccatgaat caaatccttt tgttccattg tttttgacta aaatctcgcg 1184161 gaaataaggt atcgcttcaa aaaaatcaga atttggccat tcaccatttg tttcatagcc 1184221 taattctttg atagcctgat gatcttgttt agacgcggcg tcaagaaggg gaatatcaat 1184281 cgtttgtaat cgtaatcgat tcgtttcaag gagaaccata tatttaatcc tcttttcttt 1184341 ttactgggaa taatgataac atataacaat tttctctggt accttggcag tagagaaaga 1184401 tgaaaaaatt gagggggatt gaaagagtga caggtgagag tttgcccaga ccaaaaacgg 1184461 gtaggaaaat gctgatgtta atgtgtccct acccgttttt ctgttcctga atgcagggtt 1184521 tctgataaca tgttgtgcta ccttttcgca atcaaataaa gcgatatggc tctttgggtt 1184581 tgcacaggat tatgaatgat aatgacccat tggtttcttc gtcttggaaa gcttgctacc 1184641 gcatacaatg gagcagtatc gcgcggagtg aacccaccat ttatcacgtt gatatctctt 1184701 ccttcaagat gacaaactaa gtattcacct ggattgatga cctgttggtt cgtccatgcg 1184761 taagaataaa agccgtctcc aagatcttcg gtggaagatg gggggacaaa gccatctaca 1184821 gtcaatgtga tttctcttct tcgctgtctt tctgaaaagt ctggacttct ttgagggtta 1184881 tgagtatgtg aaaagtaagg aattaacgca gggccataaa agtaatgata caaagcaacc 1184941 actcctttat tttccattca tacaaattgt atgtgggagt tatttgttca ttcctgtttt 1185001 gttccatgta gactaataat gggctatagg cgtccaagga aatcaatttg tccttccgtt 1185061 gattcaatgc tagtaacctt gaaaatgcag gttaggatga tagaatttac atattactgc 1185121 aagaagttag acatacatca ttttgatagt gggtgaaaac aatggcgaaa aaaatggcaa 1185181 aaacaaatgc ggttcgtctg atagaacagc agaacatctc ttatgaggta ttagggtata 1185241 aaacagacgg ccagccggta gatggcatct ctgttgcgga aaaaatcggt tattctttga 1185301 aatatgtata taaaacgttg gttgcagcag caggaacaaa tcattattat gtctttgttg 1185361 tacccgttgc agaagagtta gatgtaaaaa aggcagcaaa ggtgacaggg gaaaagaaaa 1185421 tagaaatgat tgcaatgaag gagctgttag cggtaactgg ctatcttcgc ggcggctgct 1185481 cgccaattgg catgaaaaaa ttgttcccga cctatattga tgcatctgca gaaacgcttg 1185541 attttattat tgtcagtgca gggaaaatcg gtatgcagct aaagttggcg ccacaagatt 1185601 tagccagatc atgtgatgcc gcatttgcag aaattgtata gatgcagata taggggaacg 1185661 aaaaagctta gtcatatcga ttaagctttt tccgcatccc tttcaaatat gatttcaaaa 1185721 taagcagctg ccccataccc atctatactg ggagcgaaaa tctgaacgaa tctccagcct 1185781 cttttcgcat aatcatggat gatttgctgg tagtcttctt taggccttct tctcatcgta 1185841 ctcagctcaa ctcttacgaa ttcatattct ttcatcgttt gatccctcct attaaggtat 1185901 acgtaaaatg gagcgagaag ttccgaaaac ctaggttaag gtcggaaagt atatttcact 1185961 cactaaacaa atccatttat gcctgatgcc tgcatgcatc tgggaagagt taaggggcta 1186021 taaaaacgaa ttttaccggg tcagcagtcc aaatgaatct cttgcttatt gcatttgact 1186081 gagtatataa gtaaaaaaag agcggccaga acatataaga aggagatgat cattaacgca 1186141 ctcataacag ggtagtgttt agcggagtag atgaaaaaat caagctgtga aatttgtttg 1186201 gggctgctga cggcatcaat tccattaagc agttttgaga gtttagcagt atagttccaa 1186261 tcaaatcgat ctgaaacaag ctcgcttcct tgataccaat taacagcagc taaaaacaga 1186321 aataccataa tagaaaatcc aagctgaaca actaaaaata ttcccttcac ttttgtatga 1186381 cctccaaatc tatgaatatg ggaaaatcaa acaatatatt accaccgtat gggttattct 1186441 tgcaatttca cttccataca actcaaacgc aagtctattt ttttgtttgt ttttggctta 1186501 taatacctga tgatggaaaa agagtgcggg tttatagatt agagaaacaa atgtatttct 1186561 tagcattttt tatttgtgga gagagtatag aagcattcga ttagatctgc tttttcacag 1186621 aaacggtttt catctgtttg cctgagcttt acaattggct ggcaaaaaaa caatgatttc 1186681 tttcaatcaa aacatgcaac gatgcgacac attttatatc ttgatgactt atttcattgc 1186741 ctttaagtca tcctatcgag aaagcgatgg tattttatga acaaagaaac cctaaaaaac 1186801 atactcatga ttttttcaat atgcgcaaca ctccgagaaa ccgatggtat gcgcatagct 1186861 gatagctgga ttttgagtga gattatacga tttttgattt gcatggttgt gttttttgcc 1186921 atgacatttc tattagatgc tgtttttcca aacaaaaaag agtcacatta atgtgtggct 1186981 ctttttgcat catctgatca gaaacatcat aaatgaatcg atcatcatga tgaagaacag 1187041 caagcaaaaa taaataagcg agtagacaaa catatccttt gcccacttca cgtcatcgtc 1187101 tgttttgaat cctttgatgc tttttttgat ccatatgcct ccgagaacca aggcggctaa 1187161 gaaataaaat gggcttatat ggccggtgcc gagagagaaa ggaaataata gcgtgaccgg 1187221 caccaggacg gcaatatatt gcatcatttt tatttttgtt acatgattgc ctttgactac 1187281 tggcaagagc ggaacgccag cagcgcgata ttcctctttg cgtcttatcc caatcgccca 1187341 aaaatgcggc ggctgccaca gaaacataat cgtgtacaac agcactgctg tcatactgaa 1187401 gtcaccggtt acggcacaat accccatcaa tggcggcgca gctcctggga agctcccgac 1187461 aaatgtgctc cacacagacg ttcgtttcac ccataccgta tagatgatcg cataaaaaat 1187521 aaaggcggcc agtccgagaa aggccgttaa tggattgagg gaataaagca tggcaagacc 1187581 tgcgattcct aaaacagagc catatgttaa gatcatggct ggcggcattt tccctgtgac 1187641 cgaggccctg ctgcgagttc gtgccatttt tgcgtccata tgccgatcaa aatagttgtt 1187701 atagacagtg ccggaagcca tcacaaacgc ggttcccaac attgctgtta ccattgtcat 1187761 caaaaaagcc aagccggtta acgttttttc tgcgcttgca aacgcgatcc aaaacccgcc 1187821 gaaggctgct atcgagtttg atatgataat gcccggcttt gcaagtttga taaaatcgta 1187881 aatggttacc cggttcgaag cttttatgta ttttgtttca gatatggctg cagaatctct 1187941 tgtattctcc aaaaatagac gcctccccca aaactgcatg cttttgttat cgtaacaaga 1188001 gggggacaga atcacaatta tttcccatat ttgtcatgat attgtcattt ttaaaacaaa 1188061 aaaatgggga gctggactgc ccccattttg atatgtggcg actagtaacc gtaacctccc 1188121 ccatatcctc cgccataacc tccgccgtaa ccgtaccaag ggtagtaagg cggtcgcggg 1188181 cgcgggtagt aataaggcgg gcgcggataa aacgggtaga acggataata cggtcttgga 1188241 taataataag gcggataaaa tggcggtctc ggacgcggat aataataagg ctgtctttca 1188301 tcataagggg taatttgttc aaatgactgt tcattcaaag ggtaatccaa gaggaaaacc 1188361 tccctagctt tttttattcc ttttaccata ttcctgatgc ttaagttggg tgtatgtaca 1188421 ttcatgaaat tcggtttttt ttatgatgaa attccttaaa aaggattgac atgaacttct 1188481 aaatctcata gtattacaaa tgtgaaataa atgttactac aatgttacaa aaacatttct 1188541 aaatagatac agttccaact gatgaagagt aaatcgaaat ggctacgaaa gaaggagttt 1188601 ttgttgttgg caaaaagaat caaatggttt catgtattaa tagcagttgt atgtgtggtg 1188661 ggccttatcg gctttttcca taatcattca ttgaaaaaag aaacggtcat gaataaagta 1188721 agaactgatt ctcaatatgg gaatgttgag atcgcaacgc ttgtgaatga cgggaaaact 1188781 tttaattacg cggtaaacta tcctgttttc aaaaatgaaa aaatggattc ggcattaaaa 1188841 agattcgcag aaaaagaggt tcgtcaattt caaaaggaaa caaaggacgt tgaccaagag 1188901 catacgacaa aacgcaacga attaaatgtt gattataaaa ttgtccatta tgccaaacag 1188961 acagtggcga ttgtatttaa tgaatataaa tacatcggcg gggcacacgg gcaaaccgtg 1189021 aaaaaaacgt ttaactatga ttttagtaaa caagcgtttc tttccattga tgatattttc 1189081 aaagaggacg ctgactactt acataagctt tcgttaatcg cttatcacga gctgaaaaag 1189141 aataaggaca ttgccgcgga cgatgcactg ttaaaggaag ggacggctcc gaaaaaagaa 1189201 aatttcagcc gctttgccat caaggaggat tatatcgaac tttactttga cacatatcag 1189261 gttgcagcag gctatcttgg agagcaatcg attgccatta agaaaagtct tttgaaagac 1189321 attctgaaag aacaatatat tgataaagca aaaaataaaa ataaaatcaa agaacaaaag 1189381 ccgaagcatg aagtgatttc tttacccaaa gaggaaacag ttgatccaaa tcaaaaagtc 1189441 attgcgctta ctttcgacga cggcccgaat cctgcgacaa caaatcagat tctagactcc 1189501 ttgaagaaat ataagggtca tgccacgttt tttgttttgg ggagcagagt tcaatattat 1189561 ccggaaacgc taataagaat gctgaaagaa ggaaatgagg ttgggaacca ttcatggagc 1189621 catccgcttc tcacaaggct ttcagtgaaa gaagcgttaa agcagatcaa tgatacgcaa 1189681 gacatcattg aaaaaataag cggatatcgt ccgacgcttg taagaccccc atacggcggc 1189741 attaatgatg aactgcggag tcaaatgaaa atggatgttg cgttatggga tgttgacccg 1189801 gaagattgga aagaccgtaa caaaaaaaca attgttgacc gtgtcatgaa tcaggcggga 1189861 gatggaagaa ccattttgat tcacgatatt taccgcacct ctgctgatgc ggccgatgaa 1189921 attataaaaa agctcaccga tcaaggctat caattggtga cagtttctca gcttgaagag 1189981 gttaaaaaac aaagagaagc gaaataaatt agaaaaggct gtccgtacgg acagcctttt 1190041 ttctatttaa taagagcctg tggtggccca aacatttaag tttggtcctg aatacttgcc 1190101 gaaagcgtaa gaagtccttg gatctaaatc atataccatc ggtgtatagc aagacttttg 1190161 gccggccacc gcttttccat tgccgcctgc agaatcacaa ttatatcttt ttccgtctgt 1190221 gttccgggta atctccgcat ttgcttcata gccagacgtc aatgtattat tcatcgtgat 1190281 ttttgcccaa gccgttttac atgtactgct gaatttaagc tcgactactc cgatgacttg 1190341 attgctggca ttcactaagt ttgaggattt ttttgtagag ccgctggacg cacaatcatt 1190401 gtaataaggg ctttttccat cgtaggcatg ggtttccgcc ttggcgggtg cacctttgac 1190461 ggcaaaaaca aatactactg cgaataacac caatgaagcc ttcataaaca gtcttttcaa 1190521 tttatgacct ccttaatatg gcaaacaata aatcatatgg aggaacaatc aaaacatgca 1190581 tgcttttttg tgaacaataa aggcggccgg gaggatggag ttcttggccg cctctggtat 1190641 gaggttatgc ttttacatca atggtttgtc cgagagttgg atgttgaatc atctttaagg 1190701 tttgatcggc attttgctgg gcggtgtcca gccttttttt cgttaaagca atatttacat 1190761 tctgggcaag ggatgcttga tgcatcgcaa ccgataaagc aggaatatcc atggttccac 1190821 ctcctatgcc ttacctatcg gcgggtttgt atgattttac agtgaaaaat ggcttaattt 1190881 ctcttgttga cccttacgct gcggcatatc gtatgttttt gacaaggagg gaatcaggat 1190941 gaatctagta atggaaaaga cctttgagca atacgaaaag ctgttttcaa tggaagaaca 1191001 gaaaagagaa gatgtatttc ggtatacgat gatgaggccg tttgaaaaga tgtggaccgc 1191061 catccaagtt ccgctgaaag cgaaggagcc aaacggctat gatgtgatca tggctgcgaa 1191121 aatgctgggc tatttggatg tccgtgatgc tgaaagcggc cagaaagcac tacaaatact 1191181 gaaagaatca catgtttcag agacagctga atctgcactt cggcaatgca tattttttgc 1191241 tgagcgcgaa cagctgcggg tgaatgcaaa ggagatcaaa ttcggccttt atatcgctga 1191301 tccaaataag cttcagctgc aaaaaggcta ctgcgggttt ggcgggatac cgggctttat 1191361 tcatgtatgg attaatccga acagttataa cctgccaagg attccttcca ttattgctca 1191421 tgagtttcat cataatgtgc ggttttcgta tatagatttt catcatggct ctgtaagtgt 1191481 cggggattat cttgtgattg aaggattggc ggaatcattc gccagagagc tgtttggtac 1191541 ggaacgattg ggcccttggg taactcgttt tgatcatgaa gacttgcaat attccattga 1191601 tgtgattaat gaggtgctgg atgtgaaagg attttcggaa gtcagccgtt atatgtttgg 1191661 tgatccaatt gctaacgacc aaggctttaa gcctgcaggt ttatcggctt ttgcgggtta 1191721 tgcagttggc tatcatgccg ttcagtcatt tatgaatcaa catcatatca cgataagcga 1191781 ggccacacgt ttggatgcga agaccattat ttctcaatgc ggtctgtttt ctacatgaaa 1191841 aaagcgtcac atacagcggc gctttttgat tcccaaaacc agcagttcta tggcggcaca 1191901 ggcggcaatt ccgattgtat atgcttcgat atcgctccat aaaaaaccgt accctagtac 1191961 aagcccgcca agagaagtat ctctaatctg gtcgatccat tcggcatgat agagctggct 1192021 gaattcaatg acaaaacaga aagaaagact gataatgccc gttatcattg tcttcagctt 1192081 ccgaaataga aatccgcatc ccgtgaagat catggcggcc cacaacgagt ctcccagata 1192141 agtattgagg gtatcaggaa gaacactgga gaatgctctg gatccaagcc ccagcccaat 1192201 gatcagtatg gtgaaaactg catatatcca acgatttcgc ttcattgcga attgataccc 1192261 cgtctctgct tcatctccct gtattgtaag gaatatagct tttatttgtc cactaaaaaa 1192321 gcggctgaat agccgcgtag ggtgtttatt ttgcttttag gtttacatgg tcggctgtct 1192381 gatccgtgcc tattacaaaa tggagttcat agcggcctgt atcatataca taatcgattt 1192441 catcggtaaa cgggacggtt aacacccgat ttactggtcc taattgcttc tgcagcactt 1192501 ccggcgtaac tccgcctaaa ttcagctgcc gttccacacc ggttccaaag tagcggattt 1192561 ctgaaattgt catgtcttta tgataggaaa atccgtagcc cggctgtccc atattccagt 1192621 gatataaatc aaatcgattg tctcccccga ctggtctttc cggttcccca aacgcagcgt 1192681 ggacatcccc ttttgtgctt ttgttaatgg taaggccttg cgcctgctga ggcatttccc 1192741 ctttataggc ggtgttatag aggtttttga caagctcagc ggctgattga ttcgtgtttt 1192801 ctgagagtgt gtttgtttga gctgcggcct ttgccggtgc tgaaaaggac gcagccccaa 1192861 agccggtaaa acagcttgtt actgctgctg ccgcggttat agcagacatt gtctttttca 1192921 tgttaatccc tcctaattga tctaccattc cgtttccccg tgtttttgca acgaaacatg 1192981 tgagtgcgct ttgtatgttt tattgagttg ttgtaaggga actgaaatag gtaattcggt 1193041 atataaagca agaaagggga atggagatgg ctggcaagaa aacaatcaca ataaacggcg 1193101 ttgaaatgga agcgtccgag gaacagacgg tgctgcagct tttgaataac agctcgattg 1193161 aagtgccgca agtttgctat catccaagct tagggccgat tgagacatgt gatacgtgca 1193221 tcgtcagcat caatggtgag ctgaagaggt cgtgctccgc tgaattaaag gatggggatg 1193281 tcattgatac gctctcacct gacgtgaaaa aagcgcaggt catcgggatg gacaagattt 1193341 tatataatca tgagctttat tgtacagttt gcgattacaa caatggggga tgcgaaatac 1193401 ataatacggt gaaggaaatg aaaatcaatc accaaagcat tccgtttgat cacaagccat 1193461 accataagga tgaatcccat ccgttttatc ggtatgatcc agatcaatgt atattgtgcg 1193521 gacgctgtgt tgaggcatgc caagacgttc aggtaactga aacgctgacc attgactggg 1193581 agcggaaacg cccgcgcgtc atttgggata acgacgtgcc gatcaatgag tcgtcatgtg 1193641 tgtcatgcgg ccattgttca acggtctgtc cgtgcaacgc gatgatggaa aaaggaatgg 1193701 aaggggaagc cggatattta acaggcatca ataacgaaac gctgcgaccg atgatcgaga 1193761 tcacgaaagg cgtagagaca ggctacggct cgattctcgc gatttctgat atggaatcgg 1193821 ccatgcgtga tgaacgaatc aaaaaaacga aaaccgtctg cacgtattgc ggcgtcggct 1193881 gcagctttga tgtctggaca aagggcagag acattctgaa agtagagccg caggaggaag 1193941 cgcctgccaa cggcatttct acttgtgtga aaggcaagtt cggctgggat ttcgttaaca 1194001 gcgaagaacg cctgacaaag ccgctgatcc gtgaaggcga tcatttccgt gaagcagagt 1194061 gggaggaggc gttattgctg atcgccagca agttcactga attaaaagag gcgtttggcc 1194121 cggattctct cgcttttatt acatcttcta aatgtacaaa tgaagaatcc tatcttatgc 1194181 aaaagctggc cagaggggtc attggcacaa ataatgtgga caactgctct cgctattgcc 1194241 aatctcctgc gactgccggc ctgttccgga cagtcggcta tggcggtgat tcaggatcaa 1194301 ttacagatat cgcgcaagcg gaccttgttt tgattatcgg ttcgaacacg tctgagtcgc 1194361 atccagtctt atccactcgg attaaacggg ctcataagct gagagggcag aaagtgatcg 1194421 tcgcggatat cagaaagcac gaaatggcag agcgctcaga tttatttgtc cagccgcgtg 1194481 ccggatcgga tatcgtctgg ctgaatgcga tcgccaaata tttaatagaa aacggcaagg 1194541 ccgatgaacg atttttgaga gaaagagtga acggacggga tgaatatgta aaaagcctcg 1194601 cgccgtacac acttgaatat gctgaggaga aaaccgggat tgatcaagaa acccttatcc 1194661 aaatggcaga gatgatcggg caagctgaca gtgtgtgcgc attgtgggcg atgggcgtga 1194721 cacagcatat tggaggaagc gacacgagca cggcgatctc taatctgctg cttgtgacag 1194781 gaaactacgg aaaaccggga gcaggttctt acccattgcg cggccataac aacgtgcagg 1194841 gagcaagtga ctttgggagt atgcctgaca gactaccggg ctatgaaaaa gtgacggacg 1194901 aacaagtccg ccaaaaatac gagcgtgtgt ggggtgtgcc gctgccgaag gagccgggta 1194961 tgaccaacca cgaaatgatt gaaaaaatcc attccggaca gttgaaagcg atgtatgtaa 1195021 aaggtgaaga aatgggcctt gtcgactcca atatcaatca tgtacacgct gcatatgaaa 1195081 agcttgattt ctttgtggtg caggacattt tcctttcacg tacagcggag tttgctgatg 1195141 tggttcttcc tgcgagcccg agccttgaaa aagaaggaac gtttacaaac acagaacgcc 1195201 ggattcagcg tttgtatcag gtatttgaac cgctgggtga atcaaagccg gattggcaga 1195261 ttattatgga ggttgccaat aagcttggcg ccggctggct ctatgagcat cctgcagaca 1195321 ttatggagga agcagccaag ctgtcgccga tttatgccgg tgtcacctat gaacgtcttg 1195381 agggctataa ttccctgcaa tggcctgtaa acgctgatgg aaaggattcg cctttactct 1195441 ttacagagcg cttccctttc ccagacggca aggccattct ctaccctgtc cagtggacag 1195501 agcctaagga attcggtgag gaatatgata tccatgtcaa caatgggcgg ctcttggagc 1195561 acttccacga agggaacctg acttacaaat caaaagggat ttcggagaaa acaccggaag 1195621 tgttcttaga aatttctcct gagcttgcgg cagaacgagg gattcaggac ggaaccctcg 1195681 tcagactcac atcgcctttc ggaaatgtca aagtgaagtg cctgattact gatcgagtca 1195741 aagggaagga agtatatctg ccaatgaacg attcagggga agcggcgatc aacctgttaa 1195801 caggcagcca tgccgataag gataccgata cgcctgctta caaagaaaca tcggccaaga 1195861 tggaaatttt gaagcacgac ggaatcagcc cgctgcctaa gatcaaccac cgcaacggca 1195921 atccgcagcc gcaaatcggt gtgcaggttc ataagaaatg ggcgcggaag gattatattt 1195981 tccctggtga cgctgtgaaa agggggatgg gccataatgg ctaaagcgat taaacgaatc 1196041 caaaaaatcg aggtaacaga agaggatcag cgaaagcgtg atttgcggga aattgaagat 1196101 gctctaattg accacaaaga agcgattctc gaaacattgc atatgctggg ccatatgaac 1196161 gagcgcgggg tcctgccgtt gctccgcggc ctttttggtc aaggggataa agttcttgat 1196221 atcctggtga aaaaggcaga tacagaggaa acagccaata cgctgaaaaa tctgcttctt 1196281 ctgtttggaa cactcggcat gctggacgtg aagcagctgg agcctctcat tttgaaagtg 1196341 aatgcgggtg tggcaagcgc tgtagagcag aaaaacagtg aagaaaagac aggttatttt 1196401 gatattatcc gctcgctaaa agacccggaa atcaacaaat caattacact gctcttttcc 1196461 tttttaaaag gaatgggaca agatacaaag gagctggaac gcacgacgca gcctccggaa 1196521 caccaaaaac atcatcagga accccgagag aaaagaggaa tgaataagcg agattgacct 1196581 cccacccgag cggcttcagc cagctcgggt tttttgatga aaaggtctaa tggactagta 1196641 aaaaatattc aaatactagg aagaagtaag attgtgatga atgagataga aataatcgtt 1196701 actttcttac ctgttaagaa aagggaaaat ctgattataa tagaaatcga ttactttaga 1196761 tgggggaaca atcatgaaaa aagtcttatt actattattt gtcttgacga tcgggttagc 1196821 gctttctgcg tgcagccaat cgagcgatgc gtcagagaag gaaaaaccga aagagaaaaa 1196881 atcgcaagaa gagcttgaaa aggaacttga taaggaattg aaaaaaggcg gtgagccgaa 1196941 gaccaaaaaa gatgatcaaa tacataaaat aggagaaaca tttaaagcag gacatacgaa 1197001 ttttacagtg aataaagttg atagagtgca aaaaggtgaa tatatgaatg ttggcggagc 1197061 tgtaaatgag gagacaaaaa caataaaaga tgatgaggaa cggcttatta tagaagttac 1197121 gatggaaaat ataggggaag attcaataag ctacaatttt atcgggtttg atttaagaga 1197181 taagaatgat caatcagtgc ggcctgtttt ttctatagaa gagaagggca gaatccttat 1197241 gggaggaaca ctagtatcgg ggaaaaaggt tacaggtgta ctcagttatg tcatccctaa 1197301 aggagaacag aaacattaca cactggtata taatccgttt ttagctgata caaatagcag 1197361 taatacagaa gagagagtaa aggacgatat tgattacttg gtgaagttag attagatgct 1197421 aatttacagt tgcacgtttt tcatctgtgg aaaacgtgca ttttttatag cgaaacttga 1197481 cttgaaagga tgagtgataa aagtgcaaac caaatggctg gaacgggcac agcggattcg 1197541 ggcgatcgcc caagcggggc ttgctttttc caaggatgtg tacgacaggg agaggtacga 1197601 agagctaatg aagcttagcg cggaaatgat ggcggattac tcggagaagg acattgaagt 1197661 tatcactgat ttatggcaag gcgagaaggg ctatccaaca ccgaaagcgg atgttcgcgg 1197721 cgctgtattc agagagaatc agattttgct tgtccgggag aagcatgatg agctgtggtc 1197781 gctgccgggc ggattttgcg agattggttt atcgccggct gaaaacgttg tcaaggaaat 1197841 caaagaagag tcggggtacg atacagagcc gtctcgattg ctggccgtgc tagacagcca 1197901 taaacactct catccccctc agccttatca ctattataaa atcttcatcg catgcagcat 1197961 gacggacggg cagggggaaa cagggatcga gacgaatcat gccgcttttt ttccggaaga 1198021 cagactcccg ccgctttctc ctaaacgaaa cacaccctca cagcttagca tgctgtttga 1198081 ctttttgcgc catccggaca agaaaacgat atttgactaa aaaagaaaga gcctgtgggc 1198141 tctttctttt ttataatgta atgtgttttt cgttggcgag tttcagaagg gtcaaaatag 1198201 aatcggcttg tttatggccg agtttttgct ttaatttgtt ttcttcaact aatcggctgc 1198261 cataaatttt gacggaggct ttgtcgacga cagtatgcca gttttcctgt ttttttccct 1198321 caacaagcgg tttttcatgt ctctcagaaa aagagaacac aaagagtacg aatgcaagtg 1198381 aaagtaggat tccgacaact tgttttttgt aatcagtctg tgctgccacg ttgttctctc 1198441 cttcaccttt taccttctat ttaatcatag aaccaaatta ttttacataa tgggaaagtc 1198501 atttttggag ttagtgcatt tggttgaaaa cagagacgtt ttttgagcgg agcggtgcaa 1198561 ttgaatccat attggatttg cgtgcttatg cctaaggtca cgttgtgagc caaaacagca 1198621 gtgcagaata gaaaaaaatt gaaagattat ggtaagatga acgaaattcg agggggaata 1198681 tatgatgcct gcatcgaaca tcgtgatcgc ctgcctgctg ttatcaattt aattatttgt 1198741 ggtagtccct ctctttttcg aaagcgggag gtgaagtgga acattaattg ctgaattctt 1198801 tcaaggggag tgaccgtaca tgaatgtgtt aaaccgccgg caagccttgc agcgagcgct 1198861 gctcaatggg aaaaacaaac aggatgcgta tcatccgttt ccatggtatg aatcgatgag 1198921 aaaggatgcg cctgtttcct ttgatgaaga aaaccaagtg tggagcgttt ttctttatga 1198981 tgatgtcaaa aaagttgttg gggataaaga gttgttttcc agttgcatgc cgcagcagac 1199041 aagctctatt ggaaattcca tcattaacat ggacccgccg aagcatacaa aaatccgttc 1199101 agtcgtgaac aaagccttta ctccgcgcgt gatgaagcaa tgggaaccga gaattcaaga 1199161 aatcacagat gaactgattc aaaaatttca ggggcgcagt gagtttgacc ttgttcacga 1199221 tttttcatac ccgcttccgg ttattgtgat atctgagctg ctgggagtgc cttcagcgca 1199281 tatggaacag tttaaagcat ggtctgatct tctggtcagt acaccgaagg ataaaagtga 1199341 agaagctgaa aaagcctttt tggaagaacg agataagtgt gaggaagaac tggccgcgtt 1199401 ttttgccggc atcatagaag aaaagcgaaa caaaccggaa caggatatta tttctatttt 1199461 agtggaagcg gaagaaacag gcgagaagct gtccggtgaa gagctgattc cgttttgcac 1199521 gctgctgctg gtggccggaa atgaaaccac tacaaacctg atttcaaatg cgatgtacag 1199581 catattagaa acgccaggcg tttacgagga actgcgcagc catcctgaac tgatgcctca 1199641 ggcagtggag gaagccttgc gtttcagagc gccggccccg gttttgaggc gcattgccaa 1199701 gcgggatacg gagatcgggg ggcacctgat taaagaaggt gatatggttt tggcgtttgt 1199761 ggcatcggca aatcgtgatg aagcaaagtt tgacagaccg cacatgtttg atatccgccg 1199821 ccatcccaat ccgcatattg cgtttggcca cggcatccat ttttgccttg gggccccgct 1199881 tgcccgtctt gaagcaaata tcgcgttaac gtctttgatt tctgcttttc ctcatatgga 1199941 gtgcgtcagt atcactccga ttgaaaacag tgtgatatac ggattaaaga gcttccgtgt 1200001 gaaaatgtaa tagataagga gactggagat tcatgaaaaa gtaccatatt tcgatgatca 1200061 atatcccggc gtacggacat gtcaatccta cgcttgcttt agtagagaag ctttgtgaga 1200121 aagggcaccg tgtcacgtac gcgacgactg aggagtttgc gcccgctgtt cagcaagccg 1200181 gtggagaagc attgatctat catacatcct tgaatattga tcctaagcaa atcagggaga 1200241 tgatggaaaa gaatgacgcg cccctcagcc ttttgaaaga atcactcagc attctgccgc 1200301 agcttgagga gttatataag gatgatcagc ctgatctgat catctatgac tttgttgcgc 1200361 tggctggtaa attgtttgct gaaaagctta atgttccggt cattaagctc tgttcgtcat 1200421 atgcccaaaa tgaatccttt cagttaggaa atgaagacat gctgaaaaaa ataagagaag 1200481 cagaggctga atttaaagcc tacttggagc aagagaagtt gccggctgtt tcatttgaac 1200541 agttagctgt gccggaagca ttaaatattg tctttatgcc gaagtctttt cagattcagc 1200601 atgagacgtt cgatgaccgt ttctgttttg tcggcccctc tctcggagaa cggaaggaaa 1200661 aagaaagcct gttgattgac aaggatgatc gcccgcttat gctgatttct ttgggtacgg 1200721 cgtttaacgc atggccggaa ttttacaaga tgtgcatcaa ggcatttcgg gattcttcat 1200781 ggcaagtgat catgtcggtt gggaaaacga ttgatccaga aagcttggag gatattcctg 1200841 ctaactttac cattcgccaa agtgtgccgc agcttgaggt gttagagaaa gctgatttgt 1200901 tcatctctca tggcgggatg aacagtacga tggaagcgat gaacgcaggt gtgccgcttg 1200961 tcgtcattcc gcaaatgtat gagcaggagc tcactgcaaa tcgggttgat gaattaggcc 1201021 ttggcgttta tttgccgaaa gaggaagtga ctgtttccag cctgcaggaa gcggttcagg 1201081 ctgtatccag tgatcaagag ctgctcagcc gcgtcaagaa tatgcaaaag gatgtaaaag 1201141 aagctggcgg agcggagcgt gcggcagctg agattgaagc gtttatgaaa aaatccgctg 1201201 tcccgcagta aaaacataaa aaccgaaatc aatttgattt cggttttctg tttaaatatt 1201261 ttttttcatc ccgcatctcc ggcattctct aagaaatttt ccgcctttta cagagctttt 1201321 gaacagtgtg taatcacagt tgtcgcagcg cccgctgcgg gcatccggat attcattgaa 1201381 ttcgtaaaca atcgatgtat cgtagccttt tgtttcatat tcttcttttt tggtttccat 1201441 gtcgatcctc cgttacaaga cgtgtctgct gtttatctta cagcaagctt ccggcgtatt 1201501 caatggattt taggaggttg ggtttatctt gatttctccc ttggtttgcg ccaaaatagc 1201561 tttattaagc ttatatacat aaaaagccta tgcaaagagg agaggaaacg ggtatgggaa 1201621 aagggttact tggaaaacgc gtggcaatcg gtggctcacg aaaaacggaa gaaattagta 1201681 caatcattga aaaacagggc ggaatacctg tcatccggcc tctccaaggt acagtttact 1201741 tagcagagaa gcaggtggag ccggatttgc ggacgtttgc ggaagaaaaa gctgactggg 1201801 tcattttcac gacaggcatc gggttggaga ctcttgtcga tatggcagag aaaattggac 1201861 tgaaagatga gtttctgcag gccattcgcc aagcgaaagc ggcatgccgg ggatacaaaa 1201921 cgctgtctgc gctgaaaaag cttggaatca caccggaagc ttcggatgaa gacgggacaa 1201981 caagaggctt aatccgttcc ttggagcctc acgacttttc aggaaaaaca gtcatggtgc 1202041 agcttcatgg cgaaaaagcg ccggctctca tggcatttct tgaagaaaaa ggcgcgtctg 1202101 tcctgccgat tctgccttat cagcacatcc cgccggagga ggaaacggtg gagcggttat 1202161 gccgagagct gatgaacgat gaggtcgatg ccgtttgttt tacaacggcc attcaggttc 1202221 gttccctgtt tgattttgcc aaggggcgag gttatatcaa tgaagtgaag aaggtattcg 1202281 aagaacgcgc catcgcagct gctgtcggaa aagtgactgc tgaagcactg cgggaagagg 1202341 gcattacgag actgcttgcg ccagagattg agcggatggg tgcgatgatt gttgagctgg 1202401 ccaagtatta tgaagaaaag gaataacaag tacaaaaagc cgcttttccc tcggaaagcg 1202461 gcttttgtct gtcattcatt ttgcttcagc tgctgatgaa cggtgaataa tgatgggtat 1202521 gtcagcacgc ttaagattac acaagtcagc gcggctgagg ccatcgttgt aaacacgatt 1202581 aagagttgaa agcgtactgc ctgaatcggg tccgcgccgg ctagaatctg gccagtcatc 1202641 atgccgggaa gctggacaag acccagtgtt ttctggcttt cgagcgtcgg gatcatactc 1202701 attttcatcg ctgaggtaag aatgcgctgt atggattgct tcggtgtgcc gccaagtgac 1202761 aatattaatt gaatttcttc tttgcgaacg ccgacttctg agttaagccg gtttagaaac 1202821 aaacttgaga gcaccatcga atttccgatg accatcccgc tgatcggaat gacatatcgt 1202881 gccgtaagcg gaatgatatg aagagacagc agaattccct gcgtcacaat ttctacgatt 1202941 gctaacgcgg caaacaccct ccaaaacgaa ccgatagtat ttttctttcg cttgatgaca 1203001 ttttgcgccg ccaccgcgag cattaacagc accatcagca ggataaaaac agggtggtct 1203061 ccgcgaaaaa tcagcgacaa aacataaccg atgataagca gctgcaccgc ggcccggatg 1203121 gtggcgatga tcatgtcttt ttctacaccg gctttaaagg attttgataa aaacaaggcg 1203181 atcaaaacaa agatcatcgt taaagagaga gaaaggtaat ccattaccga gtgcctccct 1203241 tcaaaaattc tttcgctgct tcatgctgcg gagcggagaa aaatgtgtcg gtttcagcga 1203301 tttcaagcag ccggccatct gccataaacc aaatggtatc ggctattcgt tttgcctgct 1203361 ccatattatg agtgacccac atgactgtcc attttttctc ttgatgctga cgtttgatca 1203421 gttcttcaat ctcaagagca gagaccgggt ccaaggccga tgtgatttcg tccaacaata 1203481 gaatggagga aggatttgag agcgttctgg ccagtgacag tctttgccgc tgcccgcccg 1203541 ataagtctct ggcgcttctg tctaacaact ctggcggcag ccctgcaagc gaagccagct 1203601 tttcaggaga gtacagctgg gattgatgca gcctttgtac aagacttaaa ttgtcacgca 1203661 ctgtcccgtc gagcacggga gccgattgaa acgcgagggc tgccgttcgc ctcagctcat 1203721 tgacattcca ttctctgact tcctttccgt atatgttgac ttcgccgctg tcaggcgttc 1203781 tcattaaatt acacatagaa aggagggtgc ttttgcctga gccggaaggg cctaaaacgg 1203841 ctacgattgc accctgttga atgtctccgg tgacatcctg cagcacatca taggtttgtc 1203901 catcttgttt atagcttttt ctgactgatc tgaaggagat ggctggtatg ttttgtgttt 1203961 gatcgtttgc ttccattaca ataatcacct ttcaatataa gtaggctgac attatattta 1204021 actataacgt gaaacagatt ccttttggta gcacaaataa aggagaacag gctttcaccc 1204081 attctcctgc agatgctacg cagtcagatt tgactgtgct ttctttttcg gttttctcgg 1204141 ctgtgaagcg aaggtatgta acatcatccc cgctattata atgaacaaac cggcaaatga 1204201 taatagagat gggaaaacgc ctgacagcag aacaatttca ccaagcagcg cgaaaatcac 1204261 ttcaccggat tgagtggctt caacagctgc gagtttttgc ggattgtctc ttaccatatc 1204321 agtggcccag aaaaataaaa ccgtcgcaat gatgcctgag ctgacggcaa cgataaagga 1204381 ttgaacggtt tgacttgctg ttggaaggcc atctgaccac cagccgtaag ctgctaatat 1204441 aagccagaat ggaaggcttg ccaatgtcat tccaagcacg cgctgaaatg tatcaagccg 1204501 gcctccgtat tcttcgagca ttcttcggtt tcctaacgga taggcaaaag ccgcaatgac 1204561 aaccggcagc acactgaaaa gcagcatcct cccagaaagc gattctgcat gctgaagctg 1204621 aatcagagcc gctccaatca ggatgatcac agaagtgcca agtgaaacca ggggaatctt 1204681 ttggcgaatg agctgcggac cgcccggcat atcttgtttg acataaaaca aaggagataa 1204741 gagcaccccg gctacaattg taatttgcca ggttccagct atgagccacc ccggaccgta 1204801 tgcagccgca aatgtaatcg gtgcgtaaaa aagcacgaaa ccgacgaagc tccatttgat 1204861 ccaataaaac ggctttttcc tcatttctag taagagaggc gtgaatgtcc ctctcatgat 1204921 gacaatcaaa cataaaaatg gcaccataaa aataaagcgc agcgaagagc tccaaagcca 1204981 gctgcctcct gataactcca tcgctctgtt taatataaag gtaacggcga aaaagagtga 1205041 agccaatatt ccgataacga tagctttcat gatatccctc attctggcat tattttttta 1205101 tactatacta ttcggtatca tgcagatcaa tggaatcatg agaaaaacat catgtttggc 1205161 gaaccgctat atgtggaaga caaaaaaggg aggtgaaatt gatggaaaga gagacacaga 1205221 catacttctt tccggatgac ggcaggattc cgaatcaccc tgattttccg ctcgtggtgt 1205281 atcaaaacgc gcttaaggac accggactgg cagagcggat cgtcacccgg catggctggt 1205341 caaacagctg gtcagggagt gtttttccat accatcatta tcacagcaat acgcatgaag 1205401 tcctgattgc ccttaggaga gaggctgtga ttcagtttgg gggagaaaaa ggggctgcca 1205461 tccctttcaa atcaggcgac gcagtcgtga ttccagccgg agtcggacat aaaaagctca 1205521 gctcaagccc cgattttact gtccttggcg cctatcccgg tggcgttcag tacgatatga 1205581 agacggggaa gccgaatgag cgggaggaag cggtcaaaca gattaagcag gcggcgttgc 1205641 cggcgaatga tccgatcaca ggaaaaagag agcctctatt ggaaatatgg gtaaagtgaa 1205701 ggggagaaat tgctggattg tcaataacta gtgccgcaga aacgatatga catgagctcc 1205761 atataaatta atttcataat cgaagcaatt cacgttcaaa ttttgttcaa aaagtgttat 1205821 catatagaag gtaatcgaat tggagttttt tgtgtttgct attttcagag agagtaaagg 1205881 attttgactt attcaattgt ttatttttag ataaaaataa tactgaatat ggcaagatga 1205941 aaaactgggt agtaaacatt tatttttgta aatgattgtg catgaattca caatccttat 1206001 tcttatgcct taaaagcgtg agacagggag aggcactacc ctttccaaaa aaatcagcaa 1206061 actgcttata gtaaaggaga attggatatg ccagaaacaa tcgatcaaac aaatgcgtct 1206121 gtcagccaaa gccagcaaga tcttattgat cagctattaa agccagaagt tcaagaatca 1206181 ttgactgttt tagttgacca gcttccgaag ctgactgagt tagtgaatat tttaacgaag 1206241 tcttatgatt tcgctcagtc tgtagcgact gacgaagtgt taaagagcga cacagtcggt 1206301 gcgatcactg aaattctcga gcctgtaaaa gaaacagcga aagaagtagc tgcgactgcg 1206361 atcgaagcaa aagaccgcgc ggaagcaagc aacgaaacaa ttggactttt cggccttctt 1206421 cgcatgctga aagatcctca agctcaaaag ctgttccgtt ttgctaacag ctaccttgaa 1206481 gtcatgaacg aacgcgaaaa ccaaaaataa tctcagattc aaattgatat aaaggacgga 1206541 ggatatacga tgtcaaaaca tattgtcatt ctaggcgctg gttatggcgg agttctttct 1206601 gctctaacag ttcgcaaaca ttacacaaaa gaacaagcac gcgtgacagt ggtaaacaaa 1206661 tacccaactc accaaatcat tacggaatta caccgccttg ctgcaggcaa cgtgtctgaa 1206721 aaagcggttg caatgccatt agaaaaactt ttcaaaggca aagacattga tcttaaaatt 1206781 gcggaagtaa gctctttctc tgttgataaa aaagaagttg cgcttgctga cggttctaca 1206841 ttaacttacg atgcgcttgt tgtaggtctt ggttctgtaa cggcttactt cggcatccca 1206901 ggtcttgaag aaaacagcat ggtattgaaa tctgctgccg atgcgaacaa agtcttccaa 1206961 catgttgaag atcgtgtgcg cgagtactct aaaacgaaaa acgaagcaga tgcaacaatc 1207021 cttatcggcg gaggcggctt aacaggtgtt gagcttgttg gtgagcttgc tgacatcatg 1207081 ccgaaccttg cgaaaaaata cggcgtagac cataaagaaa tcaaattgaa acttgttgaa 1207141 gcaggtccga agatccttcc tgttcttccg gatgatctta tcgagcgtgc gactgcaagc 1207201 cttgaaaaac gcggcgttga gttcttaaca ggtcttcctg ttacaaatgt agaaggaaac 1207261 gtaatcgatc tgaaagacgg atctaaagtt gttgccaaca catttgtttg gactggcggc 1207321 gtacaaggta acccattagt cggtgaatca ggcctagaag tgaaccgcgg acgcgcgact 1207381 gtaaatgact tcctgcaatc tacatctcat gaagatgtat tcgttgctgg agacagcgca 1207441 gtttacttcg gtccagacgg ccgtccatac ccgccaactg cacaaatcgc atggcaaatg 1207501 ggtgagctga tcggttacaa cctattcgct tacctagaag gcaaaacgct tgaaacattc 1207561 aagccagtaa actctggtac acttgcaagc cttggacgca aagacgcggt tgccatcatt 1207621 ggtgctaatt ctacaccgct taaaggtctt cctgcttcct tgatgaaaga agcaagtaat 1207681 gtacgatatt tgacacatat taaaggactt ttcagcctgg cttactaatc cttttaatga 1207741 atctggcatt gccaaaagca ttcctttccg agtgctttct ggcaatgtct ttttttatgt 1207801 ttatgacagc gttaacattt cattttcaaa aaagagattg atcccaaagg aatataaagg 1207861 taaaataaaa acaaatcaaa atgttaacgt taacattttg aaatagaatg aaagacggtg 1207921 aggacatgga acccttcatg ggcaaaaact ttttattgaa aaatgaaacc gctgtcagcc 1207981 tctatcacaa ttatgcgaaa gacatgccaa ttattgatta ccactgccac ttaagtccga 1208041 aagaaatcta tgaaaataag acatttcaaa acatcacgga agcctggctg tatggtgacc 1208101 attataaatg gcgcatcatg agagccaatg gaattgagga gacatacatt accggagatg 1208161 cgcctgatga ggagaaattt atggcttggg cgaaaaccgt gccgatggcg attggcaacc 1208221 cgctctacaa ctggactcac ttagaattgc agcgtttttt tggcatttac gagattttaa 1208281 acgagaagtc cgggtcggct atatggaaac agacaaataa actgctcaaa ggggaaggct 1208341 tcggggcaag ggatttaatc gtgaaatcaa atgtaaaggt cgtgtgcacc acagatgacc 1208401 ctgttgattc tcttgaatac catttattgt taaaagaaga caaagacttt cctgtcagtg 1208461 tgctgcctgg atttcggccg gataaaggac ttgagatcaa tcgtgaaggc tttcctgagt 1208521 gggtgcaggc gcttgaagat gccgctgcca tatcgattac aacctatgat gagtttttaa 1208581 aggcgttgga aaaacgagtg cgattcttcc actcagccgg cggcagagtt tctgatcacg 1208641 cgatagatac aatggtattt gccgaaacaa caaaagaaga agctggacgg attttttctg 1208701 acagattaca aggaacagag gtttcttgtg aagatgagaa gaaatttaag acatatacgc 1208761 ttcagtttct ttgcggtttg tatgcggagc tcgattgggc gatgcagttt catatcaacg 1208821 ctttaagaaa cacgaataca aaaatgatga aaaggctcgg acctgataca gggtatgatt 1208881 caatgaacga tgaagaaatt gctaagcctt tatacaagct gctgaactca gttgagatga 1208941 agaaccagct gccgaaaacg attttatatt cactgaatcc aaatgataac tatgtcatcg 1209001 ccagcatgat caacagtttt caggacggta ttaccccggg aaaaatacaa ttcggcacag 1209061 cctggtggtt taacgatact aaagacggaa tgctcgacca aatgaaagcg ttatcaaatg 1209121 ttggcctttt cagccgtttt atcggcatgc tcaccgattc cagaagcttt ctttcgtata 1209181 cgcgccacga atatttcagg cggatcgtct gcaatttgat tggagaatgg gtggaaaacg 1209241 gcgaagtgcc gcgcgatatg gagcttctgg gaagcatcgt tcaggggatt tgctatgaca 1209301 atgcgaaaca ctactttcaa tttcaagaag agaaagcaaa cgtgtaacaa agtgtccgct 1209361 cagtatcgct gagcggatca ctatccgaaa attcttaaga cacagaggtg gaacatgcga 1209421 actgaactgg caaataaggt tgtgtcggtc gaaacggaaa aaaggctttc attgaaagag 1209481 aaaatgtcct atggctttgg tgattttggc aacggtttta tgtttgatct cggccagatt 1209541 tatttattga agtatttcac tgatgtagcg ggaatccccg ctgcgatggc cggcggcatt 1209601 tttttagtca gtaagctgtt tgcagcgata acagatccaa ttgtcggctc atcaatcgat 1209661 tatcgcaaaa acatcggcaa acgggggaaa ttcaggcctt atctattaat cggcagcatc 1209721 gtgcttgcgg tgcttactgt tcttattttt ctgtctccca atgtatcaac gaccggaaaa 1209781 ctgatatatg catatgcatc ctatatgatt tggggcatcg gctattcgtt tgtgaatatt 1209841 ccgtacggct cattaggggc agcgatgact caaaattctg aggaccggac ctccatttcg 1209901 acgttccgcc aaatcggatc acttggcgcc ttgtttatca caagtgtggc cgtgatgccg 1209961 ctgctcgtca agtttgataa tccgaaggtc ggctacccgg tggtcatggg cttgttcgcc 1210021 gcgctcggtg tgttttggtt ttatatttgc taccgcaact gcaaagagcg cattatcata 1210081 tcggaagcac ccaaagaaaa attaacactc tcatctgtcg tcaaaacatt tattacaaat 1210141 aaaccgctgt taacccttgt cctgatgacg attttttcaa tttccgcata caacattaaa 1210201 tccgccatgc tcgtctattt cgcacaatat aacttgggca atgttgaatt aatggcttat 1210261 atgaacttca tcattattgg ttcttccttt ttgggcgtcg tattccttcc aaagctcgtc 1210321 aagatgtttg gaaagaaacg aacggcaatg atcggctttg gcatcagtgt ggccgcggat 1210381 ctgatcaact ttatgcttcc atctaacgtt tatgtgttta caattctcgc cagtatcgcc 1210441 tttatcggaa tcagtatccc aaatggcatc acgtgggctc ttgtctccga tattatcgac 1210501 tatggcgaat ggaaatccgg tgaacggaag gaagcaacga catattcact tttcaatttc 1210561 tcaagaaagc ttgctcaatc tttgtctggc tttctctcgg ggatcggttt ggggattatc 1210621 ggctatgtgc cgaatgcagt ccagacagca caggcgctga ttggcatcaa agcgctgctt 1210681 cttctgtatc cggccattgc tttggcatta gcgatgttca ttatcggctt tctttataaa 1210741 ctcacagacc agcagcatgc tcagatcgtt caggatcttc atcaaaagag ctgacaatat 1210801 aatataaaga atatttaaaa taatttgtaa ataaaatgtg tttgtagggg tttcgcttgg 1210861 agagtgccca aaaaactgaa aaggaaggag gcacttgctt gaaaacgata acaattgcag 1210921 ctgaagaagc aaaggaactc gtttggcaaa agctggacgg tgccggtttg aatgaacgag 1210981 atgctgaaaa agtggcagat gttctcgtgc acgctgattt gcgcaatgta cattcgcatg 1211041 gcgtgctgca cacagaacac tatgtgaaca ggcttttagc gggagggatc aatcctgggg 1211101 cacagcctgt ttttaaagag acggggcctg tgaccggggt gcttgacgga gacgatggtt 1211161 tcggtcatgt gaattgcgac atggcgatgg accatgcaat tgacatggcg aagaaaaaag 1211221 gagtcggcat ggtcacggcc gtaaacagca gccattgcgg agcgctaagc tattttgtgc 1211281 aaaaagcggc tgacgaaaag ctgatcggaa tggcaatgac gcatacagac agtatcgttg 1211341 tcccatttgg ggggaggact cctattttag ggacaaatcc gattgcttac ggagttccgg 1211401 ctaagcataa aaaaccgttt atcctagata tggcgacatc caaagtggct tttgggaaga 1211461 ttctgcaggc ccgtgaagag ggcaaagaaa ttcctgaagg atggggagtc gatgaaaacg 1211521 gagaagcagt aactgatcct gacaaggtcg tctcactttc aacattcggg ggcccgaaag 1211581 gctatggact atcgattgta gtggatgtgt tttccggatt gctggcgggc gcggcttttg 1211641 gccctcatat tgccaaaatg tacaacggcc ttgatcaaaa aagaaagctg gggcattacg 1211701 tttgcgcgat caatccatcc ttttttactg actgggatac gtttttagag cagatggatg 1211761 ccatgattga tgaactgcag caatcaccgc cggctgttgg attcgaaaga gtgtatgtgc 1211821 ccggcgagat cgagcagctg catgaagaaa gaaataagaa aaacggaatt tctatcgccc 1211881 ggagcgtgta tgaattctta aaaagcaggt gagtaaaatg aaagcggttc aagtgcgaaa 1211941 agcgtatgat ctggtgacag cggaggtgaa gaagccagtt ctttcaaagg atgatgaagt 1212001 gctcgtgaaa gtcaagcgag tcggcatttg cggttcagac atgcacattt atcatggaac 1212061 gaatccgctc gctaccctcc cgagagtcat cggacacgag gtaacgggac aagtggaggc 1212121 agttggtgcg aatgtacaga gcctaaaacc cggtgatcat gtggtgattg agccgatttc 1212181 ttattgcgga tcgtgctatg cctgccgcaa agggcggccg aatgtttgcg ccaagctttc 1212241 tgtatttggc gtacatgagg acggaggcat gcgggaatat attgtgcttc cggaaagaca 1212301 gcttcacgcg gtctcaaagg acttgccttg ggaggaagca gtcatggccg agccttatac 1212361 gataggcgcc caggcagtgt ggagaggcca ggtggaaaaa ggtgataccg tcctgatcca 1212421 gggagcgggg cccatcggga tctgtgtgtt aaaaatggca aaactggcgg gcgctgctgt 1212481 catgatgact gacttgaaca acgagcggct ggcatttgcg aaagaaaacg gcgccgatgc 1212541 tgttgtaaat gtccaagcag aacatgttgc cgagcgggtc cttgaatgga ctgggaatga 1212601 aggagcaaac gtggtcattg atgctgtttg cctgccggag acttttgcac tttcaattga 1212661 ggctgtgtca ccggcgggac atgtggttgt gcttggattt gatgaaagag cggctcagat 1212721 ttctcagctg ccaattacaa aaaaagaagt cacgataacc ggatcccgat tgcagaccaa 1212781 tcagtttcca aaagtggtag agcttttgaa tggaggccgg ttaatgcata acgggctggt 1212841 gacccataca ttttcagttg atgacgttca tcatgcattt cagtttatta aggagcatcc 1212901 agatcaggtg cggaaagccg tcatcacgtt tgattaaatg actgaatccg gaggtgcgag 1212961 catgaatatg acattccgat ggtatggacg aggcaacgat acagtcacac ttgaatacgt 1213021 gaagcaaatt cccggtgtca aaggcatcgt ttgggctctc catcaaaagc ccgtcggcga 1213081 cgtgtgggaa aaagaagaaa tcagagccga aactgaatat attcaatcct atggttttca 1213141 tgctgaagtt gtagaaagcg tgaatgttca cgaagcgatt aaacttggga acgaagaacg 1213201 cggccggtat attgaaaact acaagcaaac gatccgcaac cttgccggat ttggcgtgaa 1213261 agtgatctgc tataatttta tgccggtttt tgattggaca cgcacggaca tgttccggcc 1213321 gctagaagat ggatcgaccg ctctgttttt tgaaaaggcc aaggtggaaa gccttgatcc 1213381 tcaagagctg attcggacgg tggaggaagc atccgacatg acactgccgg ggtgggagcc 1213441 cgaaaaattg gctcggatca aagagctttt tgctgcctac agaacggtcg atgaagaaaa 1213501 gctatgggac aatttatcat tctttttgca ggaaattctt cctgttgctg aggcctatgg 1213561 tgttcaaatg gccattcatc cggatgaccc gccgtggccg attttcggac tgccgcgcat 1213621 tatcacagga gaggcaagct ataagaaact gcgggcgata tcagattcac cgtctaattg 1213681 tatcaccctt tgtacaggtt caatgggagc caatcccgct aacgacatgg tggagatcgc 1213741 taaaacgtat gccggcatcg ctccattttc acatattcgc aatgtgaaaa tttatgagaa 1213801 tggcgatttt attgaaacat ctcatttaac aaaggatggt tcgatcaaca ttcaaggcgt 1213861 gatggaagaa ctgcataagc aggattacga aggatatgtc agaccggatc atgggcgcca 1213921 tctttggggc gagcaatgcc gcccgggata tggcttatac gatcgggcac ttggcatcat 1213981 gtatttgaac gggctgtggg acgcttatga agcaatggca aaaaaagagg tgggcatatg 1214041 atcccgctgc atgagaacct ggctggtaaa acggctgtca tcactggcgg cagcggcgtg 1214101 ctttgctctg cgatggcccg ggagctagcc cgtcatggca tgaaggtggc gattttgaat 1214161 cggacggctg aaaaaggcca agcggtcgtg aaggagataa cggcggctgg cggcacagcg 1214221 tgcgctgttg ctgcggatgt gctggacagg atgtcactgg agcgggcaaa ggaagacatc 1214281 cttggccaat ttggcgctgt tgatctgtta attaacgggg ctggcggcaa tcatcctgac 1214341 gcgataaccg atgtggagac atatgaagaa gcgggagaag gccaatcctt ttttgatatg 1214401 gatgagaggg gctttctaac tgtattctcc accaacttca ccggtgcgtt tctggcctcg 1214461 caagtgtttg gtaaagaact gctgaaggcg gattcacccg cgatcatcaa cctttcttcc 1214521 atgagtgctt attcacctat gacgaaggtt ccggcataca gtgctgcgaa agcatccatc 1214581 aataatttta cgatgtggat ggctgttcat tttgccgaaa ccgggctgcg ggtcaatgcg 1214641 attgccccag gcttctttct gacaaaacaa aatcatgatc tgctgatcaa ccaagacgga 1214701 acgttcacca gccgatctca caaaattatt gcgggaacac cgatgaagcg cttcggaaaa 1214761 ccggaggatt tgctcggtac gctcctttgg ctggcggatg aatcctattc cggttttgtc 1214821 actgggatca ccgttcctgt cgatggagga tttatggctt attcaggtgt gtaacgaaag 1214881 cggtgcaaca gaaactgaac caacataggg gtgaggttga gatgttttca aaagataagc 1214941 ttcccgttat cctttttttg ttcctggcag gggtgattaa ttacctggat cgctcggcgc 1215001 tttccattgc agctcctttt attcaggatg atctcacatt gtctgccaca caaatgggct 1215061 tgattttcag cagtttttcg ataggttatg ccatttttaa ttttcttggg ggcgtggcat 1215121 ccgaccgcta tggggcaaag ctgaccttgt ttgtcgcgat ggttgtttgg tcgctgttta 1215181 gcggagcagt cgccctcgct tttggctttg tcagcctgct gattatacgc attctcttcg 1215241 gaatgggaga aggcccgctt tcggcgacca tcaacaagat ggtgaacaac tggttcccgc 1215301 cgacccagcg ggcgtccgtt atcggtgtaa ccaacagcgg cacgcccctc gggggagcca 1215361 tttccggccc gatagtcggc atgatcgcag tggcgttcag ctggaaggta tccttcgttc 1215421 tcattatgat tattggattg atatgggcag tgctctggtt caagtttgtc aaagaaaagc 1215481 cgcaagagac gatcaaggaa gcaccggcaa taaaagcaga aacgtctccc ggagaaaaaa 1215541 ttccgctcac cttttacctg aagcaaaaaa cagtcctgtt cacggcgttc gcttttttcg 1215601 cttacaacta catcctcttc ttctttttga catggtttcc gagctatctt gtcgacgagc 1215661 ggggattaag tgttgaatcg atgagtgtca tcacggtcat accgtggatt ttaggattta 1215721 tcgggctggc tgcgggggga tttgtttctg actatgtgta caaaaaaacg gcccgaaaag 1215781 gtgtgctgtt ctcgcgcaag gttgtgcttg tcacgtgttt gttttcatca gctgtcctga 1215841 ttggttttgc cgggcttgtg gcaacgactg cgggggctgt cactcttgtc gctctgtcag 1215901 tgttctttct ttatttgacc ggtgctatct attgggctgt cattcaagat gtggttgatc 1215961 aaaacaatgt cggttctgtt ggcggcttca tgcatttcct cgccaacacg gcaggaatta 1216021 tcggcccggc tttaaccgga tttattgttg accaaacagg cacgttttct ggagcatttt 1216081 tgcttgccgg tgggctggct gtcttcgctt cacttgctgt gattcgtttt gtccgtccaa 1216141 tcattggtaa gccagcggga acagaagctg agaatcctgt gtcttattaa tctggaaata 1216201 tagtgggaga ggcggtatgt ttgatgatac aatatacagt aaataatcgc agccggtatg 1216261 ataaggaagg gaattagatg gtaaccataa aagatatcgc aaaactcgca aacgtatccc 1216321 acactactgt ttccagagca ctcaacaaca gcccttacat caaagaacat acgaagaaaa 1216381 aaatattaga gctagcagag cagctcaact atacaccaaa tgtaaatgcg aaaagtctgg 1216441 cgatgcaaaa gtcgcatacg atcgggctat tctttacaag cattacaaac ggaacctcac 1216501 acagcttctt tgcagacact atcaaaggcg tcaatcaagc cataagtgag gattacaatc 1216561 tgtatgtgcg cggcattgat gatctgaaaa actatgactc cgttacaccg atgagatatg 1216621 acggcatcat tttaatgagc caaagtgaca ttgataattc ttttatttac catattcgcg 1216681 aaaaaaacat tccgcttgtc gtgctgaatc gtgatattga tgatcgtacc atcacgaata 1216741 ttttgtccaa tgacaaggaa ggctctcaag aagctgtaga atacttcatt cagtccggac 1216801 atcaagacat cgccatcatc gaggggatcg aaggctttaa atcctcccag cagcgaaagg 1216861 aagggtactt atccgcactg attcaacatc atattccgat caagcatgaa tacagtgtca 1216921 aaggacagta cgatatggaa agcggctttc aagcgatgga gcggctgctg gcactgccga 1216981 atcctccaac cgctgttttt tgttcgaatg atgacatggc aatcggagcg atgaatgcga 1217041 tattcgcaaa gggcctgcgc gttcctgatg atatttcggt gatcgggttt gatgatattg 1217101 ggttttcaca gtacatcacg ccaaggcttt caacagtaaa gcgcccagtg gagaaaataa 1217161 gcgtgctcgg tgcgcaaaaa ctcttgtcgc tgatcagcga gcccgaaaca aaagcagaaa 1217221 aaatcttgga aaacacagaa tttatggtgc gtgattcagt cagacgattg acgacgtgat 1217281 gtcccgtttt tcagcgggca ttctttatac agaaaaatgt taacgtgtgc ataaagtgag 1217341 agggaggcaa taagggtgca gaagctgaat aaaaatgtgt acgatcacta tactcagtat 1217401 ccagaaaaaa ttctccaatt cggagaagga aactttcttc ggggatttat cgattggcag 1217461 attgatcaat tgaatcaaca cactgatttt aatgggagcg tggcagttgt ccagccaaga 1217521 ggctcagaaa aaatcaaacg attaaatgag caagatggat tatatacact ttttttacaa 1217581 ggaatgaaag acggagaagc ggtaaacgag catatgatta tcaactcaat cagccgggga 1217641 attgacctgt tttctgatta tgaagcatac aaagaattgg catcaagcga aaggcttcgg 1217701 tttattatct ccaacaccac tgaggctggg attgtatgtg atgaaaaaga tcgtttagag 1217761 gataggccgc aaaaaacatt ccctgggaaa ttaactgcat ttctttactt tcgctatcag 1217821 gcttttaaag gagatcagac aaaagggtgt gtcctgatcc catgtgaact gatcgagaat 1217881 aacggtgaaa agctgaggga aacggttctt cattatgcac atctgtggaa gctggaggaa 1217941 ggatttacac agtggattca tgaggccaat acattttgta atagtttagt agaccggatt 1218001 gttccgggtt ttcccgtcga cagcattgat gagatcacgg cagatcttgg ctatcaggat 1218061 gatttgatag ttgtgggaga gcaatattat ttgtgggtta tcgaggggcc tgattggatt 1218121 ggaaaagaac ttccctttgc ggctgcaggg ctgcatacaa agatcgtcag cgacctcacc 1218181 ccataccgga ctaaaaaagt aagaatttta aatggcgctc atacagcaat gacgccagtg 1218241 gctttattat acggcttgaa gactgttagg gatgcagtcg agcatccgga agtggggcga 1218301 tttataagag agctgattga tgacgaaatt cttcctgttt taaaaatgga aggtctttct 1218361 cagtatgctg acgatgtgct gaaccgtttt aaaaacccgt atattaagca ttacctggaa 1218421 agcattgcat tgaacgccat ttccaaattc aaaacgagaa acctgccgac tcttaaggaa 1218481 tatgctgaac aaaagggaca gcttcctgaa cgcttggtgt tttctttcag cgctcttctg 1218541 tatttttatc atgataacga gacattgcag gatgatccgg cagttcttca atttttcaaa 1218601 gaggtttggt gtcaggagga tggcgacatg cttcggattg catcaagagt gttaggcgaa 1218661 cagcggctgt ggggggcaga tctcaatgag ataccgaagc tgactgatag agtcgctgtt 1218721 tacttgaatc atattcatga gctgggcatg cagagggctc ttgaacaata ctgcatacaa 1218781 gggggagagg tacgttgaag tcgtttataa agattcataa gcaagataat gtccttcttg 1218841 ctctgcggga tattcaaaag ggagagaggc tgcatgctta cggcgtgtcg attgaagtaa 1218901 aggatgatat aaaaagaggc cataagattg cattgcagtc tatcaaagaa aacgacagca 1218961 tcgtcaagta cgggtttcca atcggtcatg catcacaaga tatctcgatc ggagagcata 1219021 ttcatgtcca taatacgaaa acaaacctgt ctgatatcca attatacagc tatacaccga 1219081 gatttgatga aaatccgtat tctaatgaga accggacgtt taaaggtttt agaagagaaa 1219141 acggagatgc gggtgtacgg aatgaattgt ggattgtccc aactgtcggc tgtgtcaatg 1219201 gaatagcaga aaaaatgctg cagcgttttg tcagagaaac aggggatatc gctccatttg 1219261 ataacgtact ggtgttaaag catcaatacg gatgctcgca gcttggcgac gatcatgaaa 1219321 atacgaagca gatcctgctg aatgccattc gccatccaaa tgccggcggc gtcttggtgt 1219381 tagggcttgg ctgtgaaaac aatgagctgg caagaatgaa ggaagcactg caagatgtga 1219441 acttgaagcg ggtgaagttt ctggaatccc agtcggtgac cgacgaaatg gaggcaggcg 1219501 ttgctttgct gaaggaaatt catgaagcgg ccaaaggaga taagagagaa gacattccgc 1219561 tgtctgaact gaagatcggg ctgaaatgcg gaggttcgga cggtttttcc ggcataaccg 1219621 caaacccgct gcttggacgt ttttcagatt atctcattgc acagggaggg agtactgtgc 1219681 tgacggaagt accggaaatg ttcggcgcag aaaccatcct gatgcagcgg gctgccaatg 1219741 aagaagtgtt tcataagata gtcgatttaa tcaatgattt caaacaatac tttattaaac 1219801 atgatcagcc ggtgtacgaa aatccttcac cgggcaacaa agcgggcggc atttctacac 1219861 ttgaggataa atcgctgggc tgtacgcaaa aagcggggat ttctcctgtc acggatgtct 1219921 tgaaatacgg tgaagtactc aagacaaaag ggctgactct tttgagcgca ccgggcaatg 1219981 atttgatcgc ctcctccgca ttggcggctg ccggctgcca aattgtcctc tttacaacgg 1220041 gaagaggcac gccgtttggc acctttgtcc cgacggtgaa agtagcgaca aacaccgagc 1220101 tgtatgaggc gaagccgcat tggattgatt ttaacgcagg ccttttagca gaggatgatg 1220161 ttcatgagga atatgtgctg cgtgagttta tccactatat gattgaggtg gcaagcggcc 1220221 agcttgtgaa ccatgaaaaa aatgatttca aagaactcgc catttttaaa tcgggtgtga 1220281 cgttataata agaaaaggct atccttcaag cggatagcct tcttcattaa atcaatttta 1220341 aaccgctgac taaaataatg gaagccataa taaattgcag tggacgcggg gagaatcgag 1220401 gcgaaagatg gctcccgatc agtacgccgg gaattgaacc gaggagcaga ttagctgcca 1220461 gcatgtaatc cacgcttccg aagcttgcgt tcaaaatgcc tgctgccgta acaagaagaa 1220521 aagcatgcgc gatatcggtt ccgacaatct gtgacgcttt catgttaaat aagtaaatca 1220581 tggcgattgc aaataatgag ccggacccga ttgatgttaa tccgacgata aacccaaaca 1220641 caacaccaat aagaattgtc agcgccctct tattttcaag cggcatcagc tgccagcggt 1220701 tggggcgaag ttttctatcc aaaaacaaac gaacgatgat tgaaatggca accagcgtta 1220761 acacatatcc tagagcgtgc ttaataattt cttcctgatg ctggtgaaag gcggggaaca 1220821 aatgcaatat gccaatggct agcgaagcac tcggaatacc gccgatggct aagtatttta 1220881 ccaatttaaa gttaatcgtt ttctgccgcc aatgggaggc aacgccaaac agctttgtga 1220941 tcgagttata tacaagatcc gtaccgaccg cgatggaagg attaattcca agcacaatta 1221001 aaaggggagt taataaggcc gctccaccca ctcccgtcaa tccgactaag gctccgacaa 1221061 acaaacccat caatatgatg cttacactca tgataaaggc ctcctgaaaa cccgactaga 1221121 attcacccga atcttattcg cgttggtcaa gtattaattg taagtgctcc atcggctgct 1221181 gaaaaacccg agctctatcc gctccctgat ggtatcattc aattgacaac accttataca 1221241 tcaggagaac acgtctttca ggtgcaacga gcacttgcgg ctctgtattt ttaccctgat 1221301 aaaggcgctg ttaacaacgg aattgacggc gtttacggac cgaaaacagc tgacgcagtt 1221361 gcccgttttc agtctgttaa cggtctaact gctgacggta tctacgggcc tgcgacgaaa 1221421 gagaagatcg cagcgcaatt aagctgatca aagaccataa aaatcccgga gccgctccgg 1221481 gatttatttt ttcttcttca acttttttat aattccagca ctgcgctccc tcacccgaag 1221541 cgagtacccg gaaagcccaa accttccgta atcaacaaac ttcacacgcc tcaccaattt 1221601 tttcactgta tcacctgaca ttatcctctg tttgtattta ttatatgtca ccctttaaga 1221661 aaaggaataa ggacaagagc tgttttccct tgtcctttta gtgtgatcat gctttttttc 1221721 gtttatactc gtcaatcagc cgttcgtttt ctttgaagat tcttgctgta tgcggactga 1221781 cttgatagct tgcgacactg gtggttgaac gttttttcag gattttaaac ggcttcgccg 1221841 ctctgggctc gcatctgttt tgaaacgcac gttccattat ccttcacctt cctcctcaat 1221901 tggcagcacc aaatcatata tgctcgttaa tgacgtaaat agcaaataat caaattccgt 1221961 gacaatgctg tcagacgtca gcttgatgac atagttctgt gtctcgatgg taaaagggat 1222021 gagaaccact tttccgtatt ggtcgtaata aacatccttt cgatcgagcc gtgtttgtac 1222081 atctgccgga tcatccatat gctcggttaa ccggtcttta tcagcctgtg tcgaatagtg 1222141 gcaaagagaa gccgttaagt tcattttatc agcataggtt ttcagcagct tatcaatacc 1222201 ttcagcataa gcatctatac ttccataata aacatggatc ggttcgtttt tcaataggta 1222261 ttggtatgtt ttcagccgat tgagatacat gtggagcatt tcgttgtttt cttcaagaat 1222321 ttctcttgtg tctgtttcaa gctcgctgcc ggccagtttt ttgacatatg cacttaagaa 1222381 gataaaagca tcaatcaaag caaaactgac tgcgacaatg agataccgtt cccagtgggt 1222441 aaatagggaa gtgggctcat atgtccagta taccatagcg cccagaacaa acagcaaata 1222501 ccaagttttc cgaatggcgg acattttttc tttgaccttc gcttcgaaac gccacgtggc 1222561 atacacgtat aaccccagtc cggccacgat gcaccagacc atgatctgaa agaataaaac 1222621 catattcgaa tccctcacat ctgaaatagg ttctgcttat tgtattcgag agatccggat 1222681 ggttttcctg ttccatcaaa aaaaccgctc ctttgacaga agcggtgtga cattaaaata 1222741 tcatatttaa aataaagtag gcgatggcac caagtgtcgc tgaaatcgga agcgtgatga 1222801 cccatgtaat gagcattcgc ttggccgtac cccagtttac gccttttacg cggtgggacg 1222861 caccgacgcc aagaattgat gaagaaatga cgtgggttgt actgaccggc aaatgaataa 1222921 acgtggcgcc gaaaataatg gctgctccgg ttaagtcagc ggaaacaccg tttaccggac 1222981 ggattttcat gatctttccg ccaacggttt tgatgatttt ccagccgccg attgatgttc 1223041 cgagacccat ggctgtcgcg caggcgaatt gcacccaggt aggaatatca ttagcagaag 1223101 tatgtaaatt cgctgtgatg agagccattg tgataattcc cattgctttt tgcgcatcgt 1223161 ttgttccgtg tgtatacgat tgcagggcag ctgttacaat ctgcactctg cggaattgct 1223221 tattcgtttt cgccaagttg ctgtctttga aaatcagctt aacgatgcta taaagaataa 1223281 aaccaaggac aaaggcaata attggtgata gaatcagtgc ttcaatgatt ttaatgaagc 1223341 ccttatagtt taacgctgca aatccggctg ccgcaatggc tgcaccggca atagcgccga 1223401 tgatggcatg ggatgagctg cttgggatac cgtagtacca tgtgataagg ttccaggcaa 1223461 ttgcagcgag tagcgcagcc aaaatgacaa cagagccatt ttccagcgta taaggatcta 1223521 cgatgtcttt cgtaatggtt ttggcaacac ctgtaaacgt cattgctccg acaaagttca 1223581 tcacagcagc caatataatg gcatggcgcg gttttaacgc ttttgttgat accgaagtcg 1223641 caattgcgtt tgccgtatca tgaaacccgt tgatgaaatc aaacgccaga gcacaaatga 1223701 ctattagtat cgttaatatt aatagaatat ccatttttac ccctcgttac gcgtttttca 1223761 taatgatggt ttcaagatta ttggcaacac tttgacaaga gtcggcgatt tcttcaagcg 1223821 tttcgtatat ttcacgatat tgaatgactt tgattggatc tgtttcattt ccgaaaagat 1223881 tctttaatga ttttctgtgc aagttgtcac aactgtgctc atactcttta attttgattg 1223941 cgtgaggctg aatatccttt aagcgatttt ctgccagcag ctcgatcgta atcaaaatct 1224001 ctttcgcaca ttctctgata tatccgctga atttatcaat atgctcgtct gatgaagtaa 1224061 ttgagaaaat ctccatcatg gcagagaaat gttcgattcc gtcaagcaca tcatccaagc 1224121 tgtttgtcag ctgaaggata tcttcgcgct caataggagt gatgaacgct ttgttaagct 1224181 ctttaatcat gacatgaaca tgattgtcac cttttgtttc atattccttt aacgtatctg 1224241 caaattcttt aagagtcgtt tggttagtga ccttaaaatt cacaaaatat tctgcagttt 1224301 cgtctatgtt ctttgcaatt tctgttaaaa ggagtgagaa cttatctttt tttcttctta 1224361 tcattaaaaa ccctccatag tttgaatgaa caatgcacac atcaaattat tatatagcct 1224421 tttgtcgaaa aaaaacaggt aaagtcgaaa aaaacgtatc ttgacttttt tgataaatcg 1224481 tgtctcctta ttttgaccta cttcgcttta aaaaaacgac ccaagtttgc aaaaactttc 1224541 tgcttaacgt aaaaagtata tcaaaagttg tgtttttcct gtcaactttt atcttctgtt 1224601 tcaccaaaaa acggttccct aaacaaggga accgttttat cagcttgctt ttcgtttttt 1224661 catcccgtaa taaacaggca gtccggcaag gccgatgagg atggataatc cgcagctcat 1224721 tgtatctgta atgagtgtgc tgcctaacac aaagaaggag cccgcgattg ccagaattgg 1224781 cataaatgga taaagcggaa cactgtaggc gcgcttttct ccctttgctc gcttgcggag 1224841 aataaacact gcaaaaaagg ccatcacata aaaaatgtag atcatgaaaa tggagatttc 1224901 tgagagctta tcagggttgc tgatcagcat cataatcaaa gccaaagcaa tttgaaaaga 1224961 aatcgcaatc catggtgtgc ggaacgacgg gtgtacatgt gacagttttt cagcaaatgg 1225021 aagctgtttg cgttccgcca ttgcaaatga aacacgcggg aaagaaagca cctttccatt 1225081 taagcaccca aagatgctga cgataatccc tacactgatc agctttccgc caattgaacc 1225141 gaacagcatg gttgcagcgg tgcttgtcgc attttcacca agcgtgacaa tttcgttcgc 1225201 tgacaggatg tgaagcaatg caaaattaat gaaaatatag atcgccgtta caattaataa 1225261 tccgcccgtc atagcgcgtg gcagcagctt ttcgggattt ttcatttctc cgccgagagc 1225321 ggcaaggaga atccatccgt cataagcaaa caacgtagct aaaatagccg ccccgaagtt 1225381 catatcagaa atgctttcgt ttactgctgt gaagatgtgc tgatcgcctt tccaaaggcc 1225441 aaagacgatg atgcaggcaa tcggaatcag ttttccgatc gttgtcagcg tttggacaaa 1225501 accgccgtat tttgtaccga taatattaat gacgcataaa aagagaactg ctataattcc 1225561 aatgactttt gatagtccag atccccagcc gaaaagattc gccattaaag atccaaaata 1225621 taaacccagc gcgccaataa tcgccgggcc gtaaatgata atctgcaccc agccgcacaa 1225681 aaatccccaa aactcgccgt acacttcttc aaggtacgta taaagcccgc cggtttttgg 1225741 aatctgcgtt ccgatttccg cgattgtcaa accgcccgcc agtgttaaaa taccgcctaa 1225801 cagccaggcg aaaagcgcca tttttgaatc acctgaataa gcaagcacag cgccgggctt 1225861 cataaaaaca ccagaaccga taatggttcc gatgacaaga gtaagggcaa acaagaggcc 1225921 tatctctttt ttcaaaccgt tgtcttcagt atgcatgtcc ttaacctcct atgatgttga 1225981 agcttcatgt tgaagaatct attttttcat attgtaaacc ctattttaga aaagtgaaat 1226041 aaaataaatt ttctgatttt cgaaatttgc tttgtgtaca gcagataaaa ctgtagaaat 1226101 acctgtttta atggtctata aacgaataaa attcataatt tttatttaca aagttcgtgt 1226161 tttatgtatt aggattttag ccggtacaga ggggagatga gaattcagaa aatgaacgaa 1226221 ccttcggtga agctgatatg ttgactttct catgcgaata aaatactttg ttattagaac 1226281 aataaatata caattatgat atgatatctc gaaatcgaga taaaataacc tggagggaca 1226341 gcatatgaaa gttaacggca ttcaccacgt atcggcatta acggccgacg cacaaaaaaa 1226401 cttggatttc tataagaaag tattaggatt aaagctcgtc aaaaaatccg tcaatcagga 1226461 tgaaccgaca atgtaccatc tgttctacgg agatgaagtg gcaaacccgg gaactgagct 1226521 gacgtttttc gagattcccc gcattgcacc gtttcatgcg ggaacaaaca gtatttcttc 1226581 tattggattg cgcgttccag gcacagaagc cctgcattac tggaaagaac gttttgaaga 1226641 gcagcaagta acgcacagcg gcatctccaa aagagccgga cgtgacatat tggcatttca 1226701 agatcatgag gggcagcgac ttgtgctgac tgctgatgag gaaggaaaag gatatggcct 1226761 gcctgttaaa cagagcggca ttccggaaga attttcgttt cgcgggttag ggccggttga 1226821 actgactgtg ccatatgctg aaccaacttt acacgtattg acgaatattc ttggatttac 1226881 agaaatcagc cgtgaaccag tcgaagggca aggaaccgcc gttattctgg aatcaggaga 1226941 aggcggtgct gcaacggaaa tccatttaat agaaagaaac gatcttccgc gagagcgtca 1227001 aggcaaaggg agtgttcacc acgtcgcatt tcgggtaaga gatgaagaag aacttgccgg 1227061 gtggcaccgg atcatcagcc gcgaaggctt tagcaattca ggcatagttg agcgctacta 1227121 tttcaaggcg ctgtatttca gagaaccgaa cggcattttg ttcgagttat caacagacgg 1227181 accgggcttt atggtagatg aaaatcttga tgagcttggc caaacgattg ctcttccgcc 1227241 atatctagag catcgaagag cagaaattga agcaaaattg aaaccgatcc aataaattgt 1227301 gattcttttg ccttccggcg ccgccggagg gcttttttta ttaccataat taattttgac 1227361 ctaaacagca tgccttatta gggaggaaat atcagatgct gattgggaga aatggcttaa 1227421 aaccctttgc aaatatgggt gattggtatg gaatggcctc ggcaaaaata ttgtctttgt 1227481 ttattaatag tttattcata tttgcttgtt acactatttc aaagttagac aaaaaggagt 1227541 gaaaaataag tggaaaagaa aaaacgcgag ctggatatcg tcctcctcct cattttgctc 1227601 gcatctgcat tcttaaatat ctataacatt tggaaggacg acacggtgaa tccttattac 1227661 accgcggcag ttacaagtat gatgcaaagc tttcataatt tcttttatgc ttcgttcgat 1227721 gctgccggct ttataacagt agataaaccg cctgttacat accaaatcca aacgatcagc 1227781 gcactgatat tcggtatgca cggctggagc gtcatcctgc ctcaggcact tgctggtgta 1227841 ggttctgtcc ttcttatgta cttgctgata aagccgacat ttggaaaaac ggcggcgcgt 1227901 attgcctcat ttgttatggc atgtacgccg atagctgtag ctgtagcacg tacaaacaat 1227961 gttgatgcat tactggtatt tttcttattg cttgctacat ggcttctctt taaagcgatc 1228021 agaaaaggaa agctgatctg gctgttagca gcatttttcg ttgttggagt aggttttaat 1228081 acaaaaatgc tgcaggctta catgatttta ccggctttct tattgttcta tctgattgcg 1228141 gcaaacgcca caatcaagaa aaaaatcgtt tcattggtaa gtgcgttagc cgtattagca 1228201 gccgtttcgt tatcgtggcc gctcattgtt gacaatatcc ctgcaagcaa gcggccttat 1228261 atcggaagca gccaaaccaa ctctgttttg gaattggctt tcggctataa cggaatccag 1228321 cggctgacag gccaaaattc aggcggcggc cagggtgcgc caaacaaaga cgcttcaaaa 1228381 gaaatgtctt cttctgataa cactcaagca ccgcctaatc agtcatcaag caacagctca 1228441 tcaagcgatg gtaaatcctc aaatggcaat atggcggcgc ctccatccaa tggccaaatg 1228501 ccaagcggcg gtcaaggagg ccctccaagc ggcggagatg gcggccaagg cggacccggc 1228561 ggagacggag ggaaaggcgg tacaggaacc ggttcgaaaa tgcaatcagg ttcagggatg 1228621 tttggaacgg gaacacctgg tccactgcgg cttttccaac aagagttatc tgatcaaatc 1228681 agctggcttc tgccatttgc gatatttgga atcgcaggct tactgatcgc tggcgcaaga 1228741 gaaagaagaa gattatctgt agagcagaag gaaacggtgt tctgggttgc gtggcttgta 1228801 ccgattgccg gattcttcag tgtcgcagaa tttttccatc attattatct catcatgctg 1228861 gcaccgccga ttgcggctct tgtcggtgcg gggtgggtcg ctcttgttca tctgtaccgc 1228921 aatcagacag gctggaaagc atggcttttg ccgggagcaa ttattgcgac aactggattt 1228981 gaattgttta ttctcagaaa ctacaacgat caaatcggtg ttggatggag tatcggggta 1229041 ggtgttatcg gcgtgttgtc agcgattgct ttgctgctgt ttaaacagcg ccaaaaaccg 1229101 ttcagttatt atgtttcact tgcagctctc ctcgcattgc tggtgatgcc gatgtattgg 1229161 gcaagtacac cgcttctgta cggaggcaac agctcactgc ctgaaacagg ccctcaactc 1229221 gcatcaatga gcggaaaagg catgggaatg tctgatgcga ctgtaaatga aaaactgatc 1229281 aaatatctag aggagaataa ctccggagct gaatacctat tcgccacaac cgattcgaac 1229341 acagcggcac catatatcat taaaacgaaa aaagctgtca tggctattgg tggatacagc 1229401 ggttctgacc cggcaatcac actgactcaa ttcaaaaaac ttgtaaaaga aggaaaagtg 1229461 aaatacttct tggcttctgg aatgggaaga ggcggaaaca atgacattgt tgaatgggtt 1229521 gagaaaaatg gaaaagaagt agcatcagaa aaatggcaat caagttctga tcaaaaaaca 1229581 gaaaatactg attcagctga tacatcaagc agcaaggctt caggtgaaaa cggcaaaatg 1229641 ggcggacctg gcggaatgaa tcagtcagca acattatacg aactacatgc tgatgaatag 1229701 gaggcaaaaa catgagcaga catattcaat attcaattgt tgtacctgtg tataatgaag 1229761 agcttgtcat tcatgaaacc tatcagcgct taaaagaggt catggatcaa acgaaggaaa 1229821 actacgagct gctttttgtc aacgatggca gcaaagaccg cagtattgag attttaagag 1229881 agcacagcct gatcgatccg agagtgaaaa ttattgattt ttcaaggaat tttggacatc 1229941 agatcgccat tacggcaggt atggattatg cacaggggaa tgcaatcgtc gtcattgacg 1230001 ccgatttgca ggaccctcct gaactgattt tagaaatgat tgaaaagtgg aaggaaggct 1230061 atgaagtcgt gtacgccgta cggactaaac gaaaagggga aacctttttc aaaaaacaaa 1230121 ccgcggctat gttttaccgg cttctcagcg gtatgacaga tattgatatc ccgattgata 1230181 cgggggattt tcgcctcatg gacagaaaag tctgtgatga aatgaagaga ttaaaagaaa 1230241 aaaatccatt tgtaagaggg ctagtcagct gggtgggttt caaacagaca gcggtcgagt 1230301 atgtacgtga tgaaaggctc gccggagaaa caaagtaccc gctcaagaaa atgctgaagc 1230361 tgtcaatgga cggcatcacg acattttcac ataaaccgct gaagctggca agctatgcgg 1230421 ggattttaat gtcaggtact ggatttctgt atatgtttat cgtgctgtat ctgaagctat 1230481 tcacagacag cacgattacc ggctggtcat cacttattgt gatccagctc ctgttcagcg 1230541 gcattgtcct tctgattttg ggcgtgattg gcgaatatat cggcagaatc tacgatgaag 1230601 ccaaagacag gccgctttac atcgtccaaa aatcgtatgg aattgaaaat aaaagactct 1230661 atagagacca gcatatgtca taacctcaaa ccccctgtcc gtaatggaca gggggttttt 1230721 atgctctgag cacgatctaa agcaaaagat gctgatagat atatggaaat tgggtaaaga 1230781 agagattgtg agcttgtact gcggttcagt catgctgaaa taaaaacagc aaaacttaaa 1230841 gatttcgtcc tcggctttgc tgcatgtcag ctgttatatt ggggggcttt taagaaacgc 1230901 atgattagag ccgtaccagt tatgtttaat agaatactcg tacccaatac aattccccac 1230961 gtcaacgtcg attcagagag aagaaagctc agcaaaagaa aagccaatcc tgcgcagatc 1231021 atacccagtc ccacggtttt catgttcatg cctcctagca aacgatgttt ctagcatctg 1231081 atgtgaatga tgtcaatctg tatgatatac ggatatctcg tcagaaagtt tcatagaaca 1231141 attaggtctt ttatctaata aaaagcctca gaccgctttt acggcctgag gcattatgtc 1231201 ttacgaagtt ttctcttctt tttgatccag tttaattttt ttcgtcattt ctttgccgtt 1231261 tcggagaatt ttcacttcaa cggtatcacc gatctttgcg tctttatata agatattgcg 1231321 caattcactg cctgtatcaa tttctttacc ttttaggccg atgataatat cctccgcttt 1231381 taatccggcc ttttcagcag gagagcctga agcgacctca cggatgtaaa cgcctttatt 1231441 cagctggctg ccgaacaggc cgagtgtgcc ttcttggtaa ttttgcggca cttgctctag 1231501 atcaagcatg ctgacaccga tatatggacg ttcaatttgt cctttagaca gcaattcttc 1231561 agcaatcggt tttacgtcat tgcttggaat ggcgaatccg ataccctcaa catcatcctc 1231621 actgattttc atactgttaa tgccgacaat tttgccgtct gtatttaaca aaggaccgcc 1231681 gctgttacct ggattaattg ctgcgtctgt ctgaatgacg ttaatgctcg tttcgccggc 1231741 tgatgtagac attgaaaccg ttctgtccac gccgcttaca attccttgtg ttactgtgcg 1231801 ggacaggtct tttccaagcg gatccccaat cgcaataacg gtctcgcctg ttctaagatc 1231861 agatgaatca ccgaagtttg ccacttttgt gacgtggtca tcactgattt ggaggacggc 1231921 taaatcagtt aacgagtcac tgcctaccag ctttgcagta acctcagtgc cgtcatataa 1231981 agataccttc agtgatgatg ccccttctac gacgtggtta tttgtaatga tataagcctt 1232041 gccattctct tttttgaaaa tgacacctga ccctgaaccg ctttctgtat cttcgctgga 1232101 atcagaagaa ctagagccga acaaagagct gtttgattgt gcctgaagat ttgtaatacc 1232161 gacaatcgct ggtgaaaggt cttctaccat atctgagatt ttagaagagt cctcgctctt 1232221 gaatgcagat gagctgcttg agcttttttt agattcagag gaggtgcttg ttgctgtaac 1232281 agattgcgtt tgctgctggc tggatgattg ttttgcagtg tcctgagaat catggtcacc 1232341 aagcggtgta aacgtgtaaa tgccaagagc aagactgccg ccgatcactc cgccaagcaa 1232401 cggtctgaac catccgaatc ctcgtttttt cttctcctga tcatgaatga cattgcgggc 1232461 cgagtaggag gcgctctgat cgttctcttt cgttaaaaag acctcattct cattaccttt 1232521 cgttctgttt tcatcacgat agttatccat catgttcact ccgtttctct attttcacat 1232581 gtctatttat attgataggt ttatgacttg agtttatcat aaacaaaaac tgtgggataa 1232641 aaatgaaaag attatgggaa attgtgaaaa agtgcggaaa acggtacact tcatattgta 1232701 tatgaaagga ctgagtcgat ggaacagatt ggattgattg gatatggcag catggcggat 1232761 atgatcgcta gacagctgtt gaaacatgaa caaataaaag agaatgagct atttattgag 1232821 acgagaacga agggggagcg gctgcgggca ctcatgtcag attatccaaa cgtatcggct 1232881 gatccgttgg agaattgggc aaatacgtgc caattgattt tgatatgcgt cccgccactc 1232941 catgtcatcg aaacaatgcg ccgtctgtac ccgtatgtga acagaaatac tcacatcgta 1233001 tccatagctg ccggtgtgcc gctgcgtctt ttggaggcag aaacagaagc cggtatctca 1233061 cgtgttattc ctgccattac gtccgaagca gaagccggca tctcacttgt cgttcacagt 1233121 gaagcactgg ctgcagagaa aaaagaacgt ctgaatgaat tgttatcggt tttcagccgt 1233181 gtacgggaaa tcaaagaatc gaatttagat gtggccagca atttaacgag ctcggcaccg 1233241 ggattcatag ctgcaatctt tgaagaactg gcactgtctg ccgtcagaaa cagcagcctg 1233301 tccaaagaag aagcctttga ttttctgatt cattcgctat acggaactgg caagatgctg 1233361 atcgaaaaaa atatgtcttt cgaggagacg ctggaacgtg ttgcaaccaa aggcggaata 1233421 acgggagagg gagctgaggt gatacacgcc tctgtgccgg acgtttttga tgaggtattt 1233481 gaaagaaccc tgagaaaata tgaactgctt acagaacagg ttggtaaaca aacatgaatc 1233541 cttgaaagag gattcttttt ttatcactga atgattgaga tttttcccag ttatattgca 1233601 tttttcctct ttttttaata taatttgtta gaatattcat aatttagtaa aaaaggagga 1233661 gcgttatgaa attgtacatg tcagtagata tggaaggtat ttcgggtctt ccggacgata 1233721 cctttgtgga ttccggcaag cggaattatg aacgcggacg gcttatcatg actgaagaag 1233781 caaactactg tattgctgaa gcgtttaaca gcgggtgtac cgaggtgctg gtcaatgaca 1233841 gtcattcgaa gatgaataat ctgatggttg aaaagcttca ccctgaagca gacttgattt 1233901 ctggtgacgt caaaccattt tcaatggtgg agggactgga tgatacgttt agaggcgctt 1233961 tgtttctcgg ttatcatgcg agagcctcga ctcctggtgt catgtcacac agcatgattt 1234021 tcggcgtccg tcatttttac ataaacgatc ggcctgtcgg tgagcttgga ttaaatgcat 1234081 acgttgccgg ttattatgat gtcccggtat taatggtagc cggggatgac cgggcggcga 1234141 aggaagcaga agagcttatc ccgaacgtga cgacagccgc agtcaaacaa accatttcaa 1234201 gatccgcagt gaagtgcttg tcgcctgcga aagccggacg gctgttgaca gaaaaaaccg 1234261 catttgccct gcaaaacaag gacaaagtca agccgctcac accgcctgac aggccagttc 1234321 tgagcattga attcgccaat tatggccaag cagaatgggc gaatctgatg ccgggaacgg 1234381 aaatcaagac gggaactaca accgttcaat ttcaggcgaa ggacatgctt gaagcctatc 1234441 aggcgatgct tgtcatgact gagcttgcga tgcggacatc attctgctaa aggggtgttt 1234501 taggctttgg cgcgatacat gataaagcgt ttttgggcaa tggcagctac gattttggtg 1234561 attaccaccc tgacttttgt tctcatgaag gtcattcccg gatctccttt taacgaggag 1234621 agaggcacaa atgaagccgt tcaaaaaaat ctcgaagcct actatcactt agacgatcct 1234681 ctcattttcc aatacatttt ctacttaaaa tccatcatta cattcgattt cggaccttca 1234741 attaaaaaac cgtcggacag cgtaaatgat atgctggaac gcggatttcc cgtttccttt 1234801 gagcttggga tgacagcgat tgtcattgct gtgatttctg ggctggtgct gggcgtaatc 1234861 gctgcactcc gccgcaatgg ctttttggac tacgccgcga tgagtcttgc agtactcggc 1234921 atctccatcc cgaattttat tctggcaaca ttgctcattc agcaatttgc tgtcaatctc 1234981 aaactatttc ccgctgcgac atggacgagc ccgattcata tggtgcttcc gaccgcagcg 1235041 cttgctgtag ggccaatggc gatcattgcc aggctgacac ggtcgagcat ggtcgaagtt 1235101 ctgacacagg attatatccg cacagcaaaa gcaaaagggc tttctccgtt caaaattatc 1235161 gtaaaacacg cactcagaaa tgcactcatg cccgtcatta ccgtcctggg cacactcgtc 1235221 gccagcatct taacaggaag ctttgtcatt gaaaaaatct ttgccattcc gggaatggga 1235281 aaatattttg ttgaaagcat taatcagcgg gactaccccg tgattatggg aacgaccgtt 1235341 ttttacagcg tcattctgat tatcatgctg tttttggtcg atttggccta cggtctctta 1235401 gacccgcgca ttaaactgca taagaaaggg tgaagcgtgt gaatctccct gtacaaacgg 1235461 atgaacgcca gccagaacag cacaatcagg tgcctgatga gtggtttgtc ttgaatcagg 1235521 aaaaaaatcg ggaagccgat tcggtcaagc ggccgagttt gtcatacacg caggatgcct 1235581 ggaggaggct gaaaaaaaat aaattagcga tggccggact ctttattctt ttatttcttt 1235641 ttgtcatggc agttatcggg ccctttttat cgccccatag tgtcgtacgc caatcgctga 1235701 cagaacaaaa tcttccgccc tcagccgatc attggttcgg caccgatgaa ctcggccggg 1235761 atgtgtttac ccgaacatgg tatggcgcga gaatctcgtt gtttgtcggc gtgatggcag 1235821 cactgattga ttttttgatc ggtgtcattt acggaggcgt tgccggctat aaaggcggca 1235881 ggattgacag cattatgatg cggattatcg aagtgctgta cggactgccg tatctgcttg 1235941 ttgtcatttt gctgatggtg ctcatgggac cgggactggg cacgattatt gtggcgctga 1236001 ctgtgaccgg gtgggtcggc atggcgagaa ttgtaagagg ccaggtgctt cagattaaaa 1236061 attatgaata tgtactcgcc tcgaaaacct ttggcgcgaa aacctttcgc atcatccgga 1236121 agaatttgct gccgaatact atgggagcga tcatcgtaca aatgacatta accgtacctg 1236181 ccgccatatt cgcagaatca tttttaagct ttctcggcct gggcatacag gctccgtttg 1236241 caagttgggg cgtgatggcg aatgacggcc tgcctacgat tttatctggg cattggtggc 1236301 gcctgttttt tccggccttt ttcatatctc tgacgatgta cgcgtttaat gtgctggggg 1236361 acggattgca ggatgcgctt gaccctaagc tgaggaggta gctgtatgga aaaagttctg 1236421 tcagtccaaa atctgcacgt gtcttttacg acttacggcg ggacggttca ggcggtcaga 1236481 ggggtgagct ttgatttgta taaaggagaa acctttgcga tcgtcggcga atccggctgc 1236541 ggcaaaagcg ttacctccca aagcatcatg ggcctgcttc cgccttattc ggcgaaggtg 1236601 acagacggca ggattctatt taaaaacaaa gacctttgcc gtctctctga caaagaaatg 1236661 agaggtataa ggggagccga catttctatg atttttcaag acccgatgac ggcgttaaac 1236721 cctacgctga ctgtcggcga ccagctgggg gaagcgctat tgcgccacaa aaaaatgagc 1236781 aaaaaagcgg cacggaaaga ggtgctttcc atgctgtcat tggttggtat tccagatccc 1236841 ggagagcgcc taaagcaata tccccaccaa ttcagcggcg gtatgagaca gcggattgtc 1236901 attgcgatgg cgctgatttg cgagcctgat atcttaattg cggatgaacc gaccaccgcc 1236961 ctggatgtaa ccattcaggc acagatttta gagctgttta aagagattca gagaaaaacg 1237021 gatgtgtctg tcattctgat tacgcacgat ttaggggttg ttgcccaggt agctgacaga 1237081 gtcgcagtca tgtatgccgg gaaaatggcg gaaatcggca caagaaaaga tattttttat 1237141 cagccgcagc acccatatac aaaaggcctg ctgggctctg tcccgcggct ggatttaaat 1237201 ggcgctgagc tgaccccgat tgacggaacg ccgccggatt tattttcgcc tccgccgggc 1237261 tgcccgtttg ccgcccgctg tccgaacagg atggttgtgt gtgacagggt gtacccgggc 1237321 cagacgatca gatctgactc gcacaccgtc aactgctggc tgcaggatca acgagcagag 1237381 catgcggtgc tgtcaggaga tgcgaaggat tgaacatgaa aagggggaag aggatgaaac 1237441 gagtgaaaaa gctatggggc atgggtcttg cattaggact ttcgtttgcg ctgatggggt 1237501 gcacagcaaa tgaacaggcc ggaaaagaag gcagtcatga taaggcaaaa accagcggag 1237561 aaaaggtgct gtatgtaaat aatgaaaatg aaccgacttc attcgatccg ccgatcggct 1237621 ttaataatgt gtcatggcag ccgttaaata acatcatgga ggggctgacg cgtcttggca 1237681 aagatcatga gcccgagccg gcaatggcgg agaaatggtc tgtttcgaaa gataataaaa 1237741 cttacacatt tacgattcgg gaaaatgcga aatggacaaa cggagatcct gtaacagccg 1237801 gagacttcga atacgcgtgg aagcggatgc ttgatccgaa aaaaggcgct tcatcggcat 1237861 tcctaggtta ttttattgaa ggcggcgaag catataacag cgggaaaggg aaaaaagacg 1237921 atgtgaaggt gacggcaaag gatgatcgaa cccttgaagt tacactggaa gcaccgcaaa 1237981 aatatttcct gagcgttgtg tccaatcccg cgtatttccc ggtaaatgaa aaggtcgata 1238041 aagacaatcc aaagtggttt gctgagtcgg atacatttgt cggaaacggc ccgtttaagc 1238101 tgacggaatg gaagcatgat gacagcatca caatggagaa aagcgacacg tattgggata 1238161 aggatacagt gaagcttgat aaggtgaaat gggcgatggt cagtgacaga aatacagatt 1238221 accagatgtt tcaatcaggg gaacttgata ccgcttatgt ccctgctgag ctgagtgatc 1238281 agctgcttga tcaggataac gtcaatattg ttgaccaggc gggtctctat ttctatcgat 1238341 ttaatgtcaa catggagccg ttccaaaatg aaaacatcag aaaagccttt gcgatggctg 1238401 tggatcaaga ggaaattgta aagtacgtca cgaaaaataa tgaaaaaccg gcgcacgcct 1238461 ttgtatcgcc tgggtttacg cagcctgacg gcaaagattt ccgtgaagca ggcggagacc 1238521 tgatcaagcc taacgaaagc aaagcgaagc agctgctcga aaagggcatg aaggaagaaa 1238581 actataataa gcttcctgcg atcacgctta cttacagcac aaagccggag cataaaaaga 1238641 ttgccgaagc tattcagcaa aaattgaaaa atagccttgg agtcgatgtg aagctggcca 1238701 atatggaatg gaacgtattt ttagaggatc aaaaagcgct gaaattccaa ttctctcaaa 1238761 gctcattttt gcctgattat gcagacccta tcagttttct ggaagccttt caaacgggaa 1238821 attcgatgaa ccgcacaggc tgggccaata aagaatacga tcagctgatc aaacaggcga 1238881 aaaacgaagc cgatgaaaaa acacggttct ctcttatgca tcaagctgaa gagctgctca 1238941 tcaatgaagc gccgatcatt ccggtttatt tttataatca ggttcacctg caaaatgaac 1239001 aagtaaaagg aattgtccgt caccctgtcg gctatatcga tttaaaatgg gcagataaaa 1239061 actgatggag gcgattgagg aaatactgct tctttatgcg aaggagcggt attttttctc 1239121 tttcttgcac gtatacgtag ggtgcagagc aaatgaaagg agtgttttcg ttgaattaca 1239181 agccgaaagc gttgaacaag ggtgatacag tcggagtgat cgcgcccgca agtccgccgg 1239241 atccaaaaaa gcttgacacc gcgcttttat ttttagaaga gctcggtctt caggtgaagt 1239301 tgggcaaggc gctgaaaaac cagcacggct atttagcggg acaggatgat gagcggctgg 1239361 cggatctcca tgagatgttc agagacgatg aggtaaaagc agtgttgtgc gcatgcgggg 1239421 gttttgggac aggacgtatc gccgcgggca ttgatttcag cttgatccgc aaacacccta 1239481 aaatcttttg gggatacagc gatattacgt ttttacatac tgccattcat caaaacacag 1239541 gtcttgtcac tttccatggc ccgatgctca gcacggatat tggccttgac gacgttcacc 1239601 cgctgacaaa agcgtcatat aagcagctct tccaggagac ggaattcacc tatacagaag 1239661 agctttctcc gctgaccgag cttgttcctg gaaaagcgga aggcgagctt gtcgggggaa 1239721 atctgtcttt gctgacgtct acactgggca cgccatttga aattgatacg agaggaaagc 1239781 ttctgtttat tgaagatatt gacgaggagc cttatcaaat cgaccggatg ctgaatcagc 1239841 tgaaaatggg ggggaagctg acggacgcgg cgggaattct agtttgtgat tttcacaatt 1239901 gtgtcccggt gaagcgagag aagtctctct cgcttgagca ggtgctggaa gactatatta 1239961 tttctgcggg caggcctgct ctgagaggat ttaaaatcgg ccactgctcg ccaagtattg 1240021 ccgttccgat cggtgcgaaa gctgctatga atacagcaga aaaaacagcc gtaatagagg 1240081 cgggcgtttc agaaggggcg ctgaagacat gaaaatcatt cgaatcgaaa caagccgaat 1240141 cgctgtcccg ctgacaaagc cgtttaaaac cgcacttcgc actgtgtata cggctgaatc 1240201 agtcatagta aggattactt atgacagcgg tgcagtcgga tggggagaag cacccccgac 1240261 gttagtgatt acaggagaca gcatggatag cattgaaagt gccatccacc atgtgttgaa 1240321 gccggcattg cttggaaaaa gcctggcggg ctatgaggcc attctgcacg acatccagca 1240381 tcttcttaca ggaaatatga gcgcgaaggc tgctgtagaa atggctctat acgacggctg 1240441 ggcgcagatg tgcgggctgc cgctttatca aatgcttggc ggatatcgag atacgctgga 1240501 aacagattat actgtcagtg tcaactcacc tgaagagatg gcagctgatg ccgagaatta 1240561 tctcaaacaa ggctttcaaa cgctgaaaat aaaggtcgga aaagatgata ttgcaacaga 1240621 tatcgcccgt atccaggaaa tcagaaaacg tgtcggatca gctgtgaaac tgcgtttaga 1240681 cgctaatcag gggtggaggc cgaaggaagc ggtaactgcc attcggaaaa tggaggatgc 1240741 gggcctaggc attgagcttg tcgagcagcc tgtccataaa gatgatctcg ctgggcttaa 1240801 aaaggtgaca gatgcaacag atacgccgat tatggctgat gaaagtgttt ttacaccgcg 1240861 ccaggcgttc gaagttctgc aaacccggag cgcagacttg atcaatatta aattgatgaa 1240921 agcgggcggc atcagcggag cagagaaaat taatgccatg gcggaggcct gcggggtgga 1240981 gtgtatggtc ggcagcatga tcgaaacgaa gctgggcatt acggccgcgg cgcattttgc 1241041 ggcaagcaag agaaacatca cacgctttga ttttgacgcg ccgctgatgc tgaaaacaga 1241101 tgtattcaat ggcggcataa catatagcgg cagcacgatt tcgatgcctg gcaaaccggg 1241161 cctcggaatc atcggggctg cgcttttgaa aggggaaaaa gagcaatgat gcacactgtc 1241221 atatcagcag tggccaacat ctggacagcg cctgattcac ctcgtccgtc tgatcaattc 1241281 atgcttcaac cgactgtaat gatcagagac tggctggagc gcatgacgta tgatgaacgg 1241341 cttggattat gtacagacaa tgtaatccaa actcaggttc tctttggcga aaaggtactt 1241401 gtgacggcgg aacaggggga atgggtttct gtgatcgtgc ctagccagcc atcccgaaag 1241461 gatccgcgcg gatacccggg ctggatgaaa aagtaccagc tggaaaaaac aaagcccatc 1241521 catacacaac acgatgtgat gatcagcaaa cctgctgcct ttttgtacag aagcaatggg 1241581 gaaaaggaga tcgaattaag ctttttgaca gttctgcccc ttattgcaaa agaaaacgga 1241641 tattttaagg tttcgaccgt ttttggggaa aggtttgtga ggcaaagtga tgcagtgcct 1241701 gtcagccaac agaaagggac tgctgaagac atcattcaaa cgggtgcgtt ttttcttggc 1241761 cttccctacc tgtggggagg gatcagcggg tttgggtttg attgctccgg atttatgtac 1241821 agtatattta aggcgaatgg atacagcatc ccccgtgatg cgggagatca ggctaaggca 1241881 gggaagggtg tcccgcttga tgatatgaaa gccggtgatc tgctgttttt tgcttatgag 1241941 gaaggaaaag gagcgattca tcacgtcggt ctgtatgtag gcggcgggaa aatgcttcat 1242001 tctccaaaga cagggaagtc aatcgaaatc ctcacattaa cagagacaat ctatgaaaaa 1242061 gaattatgtg cggtgcgccg ctgtttttca gaataaggag ggagacaaat gaggcgactg 1242121 cctttgttag aggtcagcca gctgaaaatg cattttgacg cagggaaaaa gcggacagtc 1242181 aaagctgtcg acggggtcac ctttcagatt cgtgaaggag aaacgttcgg gctagtcggg 1242241 gaatcagggt gcgggaaatc aaccttgggg agagtgctga tgcgccttta tcagccgaca 1242301 gaaggaagcg tgacataccg cggcacaaat cttcatgcac taagtgaaaa agagcagttt 1242361 gccttcaacc gcaaactgca gatgattttt caggaccctt atgcttcact taacccgcgc 1242421 atgaccgttc gagaaattat tttggagccg atggagattc ataatctcta caatacccat 1242481 aaagcacggc ttctcgtcgt ggacgagctg cttgaggcag ttgggcttca ccccgatttt 1242541 ggcagccgtt atccgcatga attcagcggc gggcaaaggc agagaatcgg gattgcgaga 1242601 gcactgtcgc tgaatcctga atttatcgtg gcggacgaac cgatttctgc acttgatgtc 1242661 tctgttcaag cgcaggtggt caacctgctg aagcggcttc aaaaagagaa agggcttacg 1242721 tttttattca ttgcccatga tctttcgatg gtgaagcata tcagtgacag gatcggtgtt 1242781 atgtacttag gacacatgat ggaaattaca gagagcggca ccttgtatcg tgaaccgctc 1242841 catccctata caaaggcgct tttgtcctcg attccgattc cagatcctga attggaggac 1242901 aagcgtgagc gtattctctt gaaaggggag ctgccgagcc cggtcaatcc gccaagcggc 1242961 tgcgtgtttc gtacccgctg tccggaggcg atgcctgaat gtggagaatc tcgtccccag 1243021 cttcaagaaa tcgaacccgg ccgttttgtc gcttgccatt tgtatcgaaa tgctgaaacg 1243081 aaggaaaaag taagataaat aaaaagagtg gctccttttt actagagcca ctccatttgt 1243141 ttatacttga tgtaaaaact ttacacaaac cgggtaaggg acagaaaccg ttgatgggag 1243201 gagtgtcaat cggccggttt ctttgtctct ttcaaacaag acaaggttgc ctgtttcttc 1243261 atttgaagca acgaggaacc cttccgttgg gtcaaataca aagtcacgag gccagtttcc 1243321 ttctgtcgac actctttcta cgaaagccag ctctcctgaa tattgattca cttcaaatac 1243381 ggcgatactg tcatggccgc ggtttgcgac ataaacaaaa cgtccgtcct gcgtgacatg 1243441 tattgcgctt ccctggctgt tatctgtaaa atcatcaggg atggcagaaa cgacttggat 1243501 ttctctaaat tcgccggctg tcgggttgta ttcaagcgca atcacttcat tgcttaattc 1243561 tgtcatgaca taagcgtatt tttctttcgg atgaaaagcg atatggcgag gtcctgcacc 1243621 gggagcgaag gaatggcttc cggattcagt caacacaccg tctttaagct tataggtgta 1243681 gagcttatct atacctaaat caaccgctac cacataattg tgttcaggtg tgaaccccgc 1243741 gtagtgtgta tgcggttttt cttgtctttc gtgcggccct tttcctgtgt gagcggcctc 1243801 tgaaacaggt gattgcaagc tgccgtcttc ctgaaccgga aaaacgtgta ccttcccgct 1243861 gtgataattg gcagtcagta cgaattgatt ttgatcatca acgcttacgt ggcatggcga 1243921 agggccatca attaactgat gattcagaaa tgtcaattcg ccgctgtttt tatcgatttg 1243981 ataggcagca actccgcctt ggccgtctgc tttttcgatg gaataaagga tggtgttgtt 1244041 tttattcgtc gccacatatg tcgggttgcc cagcttagcg gccagctttg gctcgctgag 1244101 tgcttttttc tcagtatcaa gctcaaatga ataaattcct tcgcttccgc cttttgtata 1244161 tgttcccaca tatcctatgt attttgtcat gcgatttccc ccttaaaaat gatgtcacct 1244221 ctatattaac gtatcttgat aaaataagct gttcaaaaca tgaaaaaggg gaagattctt 1244281 cattcgcctc gaatcagcgg cattgtgcag cacctgaagg agccgcctga tttaataatt 1244341 tctgacaggt caatttcgat aatgtgatag cctcttttcg atagctgttg attgacatgg 1244401 cggttgccag ggagactgat gatcgttttt tttccgattg aaaggacgtt ggtgccaagc 1244461 gtaaattgtt cgtcctcggg cacctcaata agatcataac gttttgccag catatcggct 1244521 gcatctggct caatggcctg tgaataaatt aacgcttcgc tttcagatat aatgttaaat 1244581 acgcagtcca aatgcaaaaa tttttcatga agcttcactg gaacgatcgt atattcagga 1244641 agtgcctctt ctagctggcc gatagctgaa atgtcggtgc gctggctgat tccgacatag 1244701 acaatgtcat catcgataat gacgtctccg ccttcaatac tcgtatcaag catgcgggtg 1244761 taagagatac cttggctgtg aaaaaaatct tttataacgg cttcttctcc ttggcgaatc 1244821 ggttcagtca tgcttgacag aaaggctttt tctccgatga caaatcctat gtccctagta 1244881 aaaacctgtt ctgggagtcc gtcgcgaacg ggcaaaagga cgacctcaac gttgtgtgac 1244941 ctaagtgcct ccactaagcg gctgtgctgg tcgttagcgg tttttacatg aatattgtca 1245001 tcttcaaaat gtttttgtgt ttcgtttata acatctttta tggtcatgtg ctcaggtttg 1245061 cataagatca ctttttgaag tgtgccgtat tccgttcggc ataccgtttt gtgctgagat 1245121 ttcgggatgg atacgtccat ttgtttttcc tcctaaagtg tgaagaatac atttattatt 1245181 ccctcatcat gaaaatcatt aaaccatttt aaattttaga caaatggaag agaatattgt 1245241 ttaataggag aatataagtg catttagcta aaagatcaga catcaaaggg gagaaaggta 1245301 tggaaacacc ggaaacaaga ttttgtaaag agtcaaaggt tgtgaaaacc agcagggtgt 1245361 tcccgcttga cacgaacaac cataatacgc tgtttggcgg aaaattaatg agctacatag 1245421 acgacattgc ctctatttca gcggcgcgcc attgcagacg tgaaacggta acagcttcaa 1245481 tggattctgt agatttttta aagccgatcg ggcaaaagga ttctgtctgc ctagagtcat 1245541 atgtgacatg ggtcggcaca tcttccatgg aagtatttgt gaaagttatt aaggagcatt 1245601 tgatgactgg cgaacgggaa ctcgctgcca catccttttt gacatttgtc gcattagatt 1245661 caaatggcaa gccggtgcct gtaccgaggg ttgtaccgga aacagaagaa gaaatcatgc 1245721 tgcataatac agctgtacag cgtgctaatg aacgtaagaa ccgcaagaga cacagccagg 1245781 cgcttgcaaa tgcgctcgga actgataagc cttggtgaac gttaaaccca aaacataagt 1245841 tgttttgggt ttttttgtac ttttcaatgg tgattattac aatggttagt ccgtttttgc 1245901 taggggattc tataaaaaag caacaaatgt catgttaaat tgataatttt gtgacaactt 1245961 tattaaagat tcattttaga tatatctttt attcgtaaga tcatgtattt taaagatata 1246021 ttttaaatac atcttttcga aaggattgtt tataaaatgt tagataacaa aacaatcgaa 1246081 attattaaaa gcactgtacc cgtattgcaa cagcatggag aaacaatcac tggccgtttt 1246141 tacgatcgga tgtttcaaga ccatccagag cttttgaaca tttttaatca aacaaaccaa 1246201 aagaaaaaaa cacagcgaac tgcactggca aatgccgtta ttgcagctgc ggcaaacatt 1246261 gaccaattag gaaacatcat tccggttgtc aaacaaatcg gccacaagca ccgcagtatc 1246321 ggaattaagc ctgagcacta cccaatcgtc ggtaaatatt tgctgattgc gattaaagat 1246381 gtattgggag acgctgcaac tcctgacatt atgcaggcat gggaaaaagc gtacggagtc 1246441 attgctgacg cgttcatcgg aattgaaaaa gacatgtatg aacaggctga agagcaagcc 1246501 ggcggctgga aggagtataa gccattcgtt atcgcaaaaa aagagcggga aagcaaagaa 1246561 attacatcct tctatttgaa accggaagac agcaagccgt tacctgaatt ccaagcaggg 1246621 caatatatca gcatcaaagt gcggattcct gattctgaat atacgcatat ccgccagtac 1246681 agcctgtctg atatgccggg aaaagactat tatcgaattt cagtgaagaa agatggtgtc 1246741 gtgtcttcct acttacacga tgggctgcag gagggagatt caatagagat cagcgcaccg 1246801 gcaggggact ttgttttaga tcatgcatca caaaaagatc tcgttttgat cagtgccgga 1246861 gttggcatta caccaatgat cagcatgctg aaaacatctg tttccaaaca gcctgaacgg 1246921 caaattctgt tcattcatgc ggcgaaaaac agtgaatatc atgcattgcg ccatgaagta 1246981 gaagaagcag caaaacattc tgctgttaaa acagcatttg tgtatcgcga gccgacagag 1247041 gaagaccgtg caggtgatct gcattttcat gaaggacaga ttgatcagca attcctcaaa 1247101 gaactgattg ccaacacaga tgcggattac tatatttgcg gttcaccgtc gtttattacg 1247161 gcaatgcata agcttgtatc agagctcgga tcagcgccgg agtctatcca ttacgagcta 1247221 ttcggcccgc aattaagttt ggcgcagtcc gtttgaacac atacatgaaa ctcttctcct 1247281 ttcagagaag agttttttat tgagatataa gaaggcagac aagcgccggt ttctacatcc 1247341 ggacaatcac agacccgctg ccatttgtgc atacacggtt ttgctgttct tgcattgttc 1247401 tcagcaattc attgtttacc tcaatcgctc taattagttg cttcattctt agctccaaac 1247461 cggccagcct gtcgattgtt tgctgctggt agccctcggg ttggggagcc aatggcagat 1247521 caaagggcca aagggtattc gacttctgat ttttcatatt gcgtattgcg cctccaatcg 1247581 gtgtcacttt ctattatgtt atgttcaggc gatatgcacg ttcgcctaga cactgatgca 1247641 tagagggcct gccacggggc acaataggct caatatgacc agcggatgga ggtaaagatc 1247701 ggtgttatgg atggtatggg tatttttact gaagccagtt atcgtatttt cgattgcata 1247761 tattttgttt cggcttgccg gtaaaaaagc tgtgtcacaa atgaacaatt ttgacctgct 1247821 tttgaccttc gcaatcggaa ccattatcag tgagccgatc cttacatcca agctgccgat 1247881 gtcaatttat tatgcgggtg cttttttggt gctttatctt atcatgagca agctctcttt 1247941 atctaataaa tggcgatggc tcctagtcgt gagcccgact gtcctaatcc gaaacgggga 1248001 tattgatgaa cgcggccttc gtaaagaaag gctgactgtt aatgagctgc tcggaaagct 1248061 gagggaaaag ggctatgccg acccggctga cattgatctt gctatcattg aagaaacggg 1248121 agaagtaagc gtcatcccga aagaggaagc gagagcggtg caggtgcggg atttgaatat 1248181 ggaagctgaa cggaatttta tcccgattcc gctcatactg gatggcgaaa tccttgatca 1248241 taatttgaaa tatctccaaa aaaaccgatc ctggctgttt gagaagcttg aggaaaaagg 1248301 gtacagcccc aaactgctgt cttcgattat ccttggcacg atgaatgcac gcggtgatat 1248361 atcccttgat ttaaataccg ctaatgaacc gcagcatgat ccttacttat ataaaccggg 1248421 aaataacaat taagatggct ctctcttgta atgagagctt ttttcttttt taaagggaat 1248481 ttttgtttgg tgtcaaatgt acctagttag gaggggaact gaacatgaag gacttatcca 1248541 taagaaacga catggcgcca acggtcagtt tgctgtattc cgcagtggaa gaaaacagtc 1248601 tccgtctggc ttccatcgta agccatatga cacacagtga actttactat aaggggcgct 1248661 gccaaacaaa aaacagcacg gctcagcttt tgcaccatat cacaaatgtt gatatcagat 1248721 gggtctggcg tatcaaggaa aatcggatcc cggaccatat tgaacaggca tacggcccga 1248781 tgacagatga aagcggacgg ctgcctgaac cggtgaatca gccagactta gatgaactcc 1248841 tgaaaagaca tcagcatgta gtagagaagc tgaaatcggt atgcttcact ttaactgaaa 1248901 atgctttgaa ccagccgctt tccttcgaag gtgacaccgc gacgatacga tggggaattt 1248961 ggcatatggc agatcataac cgctatcatc aggcacatat tgaagctctc aaaaaagaat 1249021 ggaagcagga tgtggcgaag tatgaacgct aaaacgaagc ttgtgactga tcgaattcgt 1249081 ttgcgctgta tggaagatcg ggatcaagcc actttgtttg ggctgctttt taatgatcct 1249141 gacgtcatga catattattc cggtttaaaa gataagaggc aaacccgcga gtgggtcaat 1249201 tggaaccaac gaaatgaaaa agggtacggc gttagtctgt ggatcgccga agataagcgg 1249261 acaggggagt ttttggggca atgcggcatc gttccccagc agatcgaaaa tcaaaccgta 1249321 atggaaattg gctatatgtt tgcccgccgc cactggggga acggctatgc gcaagaagcg 1249381 gctcgggcct gtctggacta tggctttaac gagcggcagt tcggcaaaat ggcggctttg 1249441 attgatccgg gtaacaaagc gtccatacgg gtagcggaga aaatcggcat gcattacagc 1249501 aaaacgatca gaaaatggaa taaaccgatc gcggtatatg aaagaaaatc ttacaattga 1249561 aagatagagc tgagtttagt atcatgatat catgtaaagt tttctagggt tccgcatgtc 1249621 aattgacatg gactggtccg agagaaaaca catacgcgta aatagaagcg cgtatgcaca 1249681 cggagggaaa aaagcccggg agagtcaatc tcatgtgaga cgactgtccg gggttttttt 1249741 gttttcggag aatcttaata gatagaaagg aatgactcaa aatgaaatgg ggattggtcg 1249801 tgcttgccgc tgttttcgag gttgtttggg tgataggctt aaagcacgct gactcagcct 1249861 taacatggag cggcactgcc atcggcatca tattcagctt ttaccttcta atgaaggcga 1249921 ctcacagtct gcctgttggt accgtgtatg ccgtctttac cgggctcggc acagcgggaa 1249981 cagtacttag tgaaatcgtt ctttttcatg aaccggttgg atggccgaag ctattgttaa 1250041 ttggcgtgct cttaatcggt gtaatcgggt tgaagcttgt gacacaggat gagacagagg 1250101 aaaaaggagg cgaggcataa tgctgcactg gatcagttta ttgtgcgcgg gctgtttaga 1250161 aatggccggc gtggccctta tgaatcaata tgcgaaagaa aaaagcgtga aatgggtgct 1250221 gttgatcatt gttggttttg ccgcttcatt ttccttgctg tcgtacgcaa tggaaaccac 1250281 tccgatggga acggcttacg cggtctggac aggaattggc accgccggcg gggcgcttat 1250341 cggcatcctc ttttacaagg agcagaaaga cgccaaacgg atcttcttta tcgcgttgat 1250401 tttatgctca gcagttggtt taaaaattct gtcataaatt gatttttatc aaatcttcag 1250461 tataatggat aaatagttta gacttacaaa gataagaggg attattcatg aaatcatata 1250521 tgactcagcg gttggacgaa taccgtgacg gaaatgagga taaaggtcgg ctcttggtca 1250581 gctgccccga tcagccgggt atcgtctctg cagtttccgc gtttttattt gaacacggtg 1250641 ccaatattat agaatcaaat caatatacga cagaccctga aggcggccgg ttcttcctga 1250701 gaatcgaatt cgactgcgca ggcattcgtg aaaaaaaatc atcacttcag gcagcgtttg 1250761 cctctgttgc ggaaaaattc gacatgacat ggagcttaac tttggcgagc gaactgaagc 1250821 gtgtcgccat tttcgtttca aaggagctcc actgcctgca tgagctgatt tgggaatggc 1250881 aaaccggcaa cctgatggcg gagatcgctg ttgtcatcag taaccatgag gaagcgagag 1250941 agctggttga gcgcctgaac attccattcc actatatgaa agcgaacaaa gacatcagag 1251001 cggaagtcga aaagaagcag cttgaactgc tggagcagta cgatgttgat gtgatcgtgc 1251061 tcgcacgcta tatgcagatt ctaactcctg attttgtttc ggctcatccg aatcgcatca 1251121 tcaatatcca ccattcattc ctgccagctt ttatcggtgc gaatccgtac aaacgggcct 1251181 acgagcgcgg cgtgaaactg atcggtgcga catctcatta tgtgacaaac gatcttgatg 1251241 aagggccgat cattgaacag gatattgagc gtgtggacca ccgcgataat gcggaagcgc 1251301 tgaaaaacat cggaagaaca attgagcgca gcgtgcttgc ccgtgctgtg aaatggcatt 1251361 tggaagaccg tgtcatcgtt catgaaaata aaacaatcgt ctttaactag actgcaagag 1251421 gcccgcgcaa tgcgggctat ttttgatgac aaaaaacctt gacaagtgtc ttttttcttt 1251481 gcataatata aaaaaatcat tgagcgttga agaggattag taagcagacc tttctgtgac 1251541 agagagcaaa atgaatcgct gaaacatttt gccgcatgaa acctgccgaa cctgccttgg 1251601 agtcctaggg ggaaaaccta ggcgcataac ctggcgttac aggagagcgg agcgtgcaca 1251661 agcgcgttca atcaaggtgg taccacggaa acccatttcg tccttatgaa tcaggatgaa 1251721 atgggttttt ttattgtaga agagccgcgg aggagaataa atgaaaaaac aaagaatagt 1251781 agtgaaaata ggaagcagtt cgctcacgaa tagcaaagga agcattgatg aggcaaaaat 1251841 cagagagcat gttcaggcga tttccgtgtt aaaaaaagcg gggcatgaaa tgattctgat 1251901 tacctcgggt gccgtagcgg cggggttttc cagcctcggt tatccatccc gtcccgttac 1251961 catcaaagga aaacaggcgg cggccgcggt cggacaaaca ctgttaatgc agcaatatat 1252021 gaatcaattt aaacaatact cactgactcc gggacaaatc cttttaacga gaaatgattt 1252081 ttcgaaaaga gaacggtatc gaaacgcgta tgctacgata atggaattat tagagcgggg 1252141 cgtcattccg attatcaacg agaacgattc tacatctgtt gaagaattga cattcggaga 1252201 taatgatatg ctttctgcgt tagtcagcgg attgattcac gcggaccagc tcatgattct 1252261 cactgacatt aacggactgt atgatgccaa tccaaatgaa aatcctgagg cgaaacgatt 1252321 tgattatttg ccagagatca cgcctgaatt gcttggatat gcaggttcag ctggatcaaa 1252381 ggtcggcacc ggcggaatga aatcaaagct gttagccaca caaaccgcgc tgtctctggg 1252441 agtgaaagta ttcattggaa ctggcagcgg agagcaaaaa cttgcggaca ttttggacgg 1252501 caggggagac ggcacttata tcggagacaa agaactatct tcggttaaca acacaaggca 1252561 gtggattcag ttccactcgc cgatatcggg agaaattatc attgatgcgg gtgccgaaga 1252621 ggcgatgatc cataatggaa gcagcctttt gcccgctgga gttgtgggcg tgaacggaag 1252681 ctttccgaaa ggggcggttg tggaagtcag gggaccgggc ggcgtgatcg gcaaaggcca 1252741 aactcattac tcctccgagg agattatgga ggctaaaggc aaacgcagtg acgaacttga 1252801 ttttgagaaa acgtttgagg ttattcatag gaatgactgg gtcaatgtaa aagactagga 1252861 ggcggaaaaa tgagtgaagt ttctgtaaaa gcgaagctgg cgaaagaagc agcagccgaa 1252921 atgatcatga aaacaacagc cgagaaggat gaggcgctca gcctcattgc aaacggactc 1252981 cgcaaagaac tggattttct cttggcggag aatgcaaaag acattgtgaa cggaaaagag 1253041 aatggtttaa caccggacat cattgaccgt ctctcattgg atgagaaacg gatacgcgat 1253101 atcgcggacg cggtggagct cttaatcgac ttagcggacc caatcggcga ctctcttgaa 1253161 acgattgaaa aagaaaacgg cctgtttatt gaaaaaatcc gtgtgccgct cggtgtcgta 1253221 ggaatgattt atgaggcgag gccaaacgtc acagttgatg cggctaccct ttgcctgaag 1253281 acagggaacg cggttgtgct gcggggaagc tcctcagcca tccacagcaa caaagcgctc 1253341 gtcagtgtca tttacagagc acttgagcaa tcagcgcttc cgattcacgc tgtgcagctg 1253401 attgaggata cgagcagaga gacagcaaaa gagctcttta cgttaaatga tggcttagac 1253461 gtattgattc cgcgcggagg caagaaactg attgatctcg ttgtgagaga atcaacagtt 1253521 cctgtattag aaacgggagc aggaaactgc cacatattca ttgacgaaac agccaaaccg 1253581 caaatggcag aaaaggttgt tgtaaatgcc aaaacgcagc gcccttctgt atgcaacgcg 1253641 attgaatcat tgctgattca caaggcttgg gcaagacagc acggaaaaga attgctggac 1253701 cagctggaaa acgcgggagt tgaaattcgc ggtgatgaat tggtatgtga acttcatcct 1253761 tcaagcaaac aagcatcaaa agaagattgg gaaaccgaat ttttagcgcc tgtcctcagc 1253821 gtaaagacgg ttgaaaacgt ccaagaagct gtaaagcata tccaacaata cggcaccaat 1253881 cattctgaag cgattttaac tgaaaatgac aaaaatgcgg tatattttca aacggctgtc 1253941 gatgctgccg ctgtctatca taacgcgtca acccgcttta ccgacggctt tgaattcggc 1254001 tacggagccg aaatcggcat cagcacgcaa aagcttcatg caagaggacc gatggggctt 1254061 cctgcactga cttctacaaa atacatcatt aaaggaactg ggcaaatccg tgaatagcgg 1254121 ggtaatgttc aatgaaaaag cttatctcat tacgagataa gcttttttat acgcgaaaaa 1254181 ttgacatttc aaatttaatt gtgtacaatt taattgtata aaatatattg ggggaatgaa 1254241 aaatgagtca gccattattt accgcaactg tttcagcggt aggaggaaga gaaggaaagg 1254301 tcatttcatc agaccgcgtt cttgagcttg atgtcgcaat gccggggaca ccgagagcca 1254361 agaaattaga aaaagcgaca aatccagagc agctgtttgc agcaggttat gcagcttgct 1254421 ttgacagcgc cctgcagctt gtcgcaagaa cagaacgggt aaaagtagag acagaggtta 1254481 cagcaaatgt tagcctgtta aaggatgaag cggaccaggg ctataagctg ggtgtgacgc 1254541 tgcaagtaaa aggagaagga gtcagtgcat cagaattgga ggcgcttgtg aaaaaagcgc 1254601 acggcgtctg cccgtactca aaagcaacct ccggaaatat tgatgtgaca cttgaagttg 1254661 ctgaataaat aaaaagagga tgcctgtaca aggcatcctc aatttttttg atgaagtgtt 1254721 tccagtaatg tatatagagc ggactttaac tgtttgagat cctccccaga ctgctttgag 1254781 agccccagaa ttgtccctgg aatgtcaacc gctttttctt ttaataacgc tccgtcctct 1254841 gtcaggctga tcaacacgga ccgctcatcc tcttcagatc tttttctcgt aatcaaaccc 1254901 tgttgttcca ttcgtttaag catcggagtg agcgttcctg aatctaaata cagctgttcg 1254961 cccatttttt tgacagtaag cgtttcatgt tcccataaca aaagcaaagc caaatattga 1255021 gggtatgtta tattcagctt atcaagcagc ggcttgtatt gctttgtcat ctcccgcgaa 1255081 ctcgcatata gcaaaaaaca aagctgattc tccaatttca tatgatcaaa tttattttcc 1255141 attttgttca ccaactcttt tttgtcattc gattctattg tatctgaaaa acctcacttt 1255201 tcctattctc ggcaaacata gcatgtttaa aaagatcaga aagggaaata taacaactag 1255261 atacaaataa ggaggttggg aaatatggca ctatttacag caaaagtaac cgcgcgaggc 1255321 ggacgagcag gacatattac atcagatgac ggtgttcttg attttgatat tgtcatgcca 1255381 aatgccaaaa aagaaggaca aaccggcaca aatccggaac agctctttgc ggcagggtat 1255441 gctgcatgct tcggcggcgc gctcgaacac gtagccaaag agcagaatat cgaaattgat 1255501 tcggagattg aagggcaggt cagcctcatg aaggatgaga gcgacggcgg gtttaaaatc 1255561 ggtgtcacac ttgttgtgaa cacgaaagat ttagatcggg aaaaggcaca agagcttgtc 1255621 aacgccgctc atgaattctg tccttactca aaggcaacca gaggaaatgt tgatgtaaaa 1255681 ctagaattaa aataatgacc ggcatcctga ggattctcag gatgtttttt ggtgtcggac 1255741 atgcggggcg ggcacagatt tatgataaaa cttcagagaa gcgtttgaag catgccttta 1255801 aaccaaaagt tacagatgaa gcgggtggct ggcacggtgt ctgccgtgct gaattgcgcg 1255861 tatatgctgt tttgtatttg cacagggcat agcggctact tggagaaata acaaggacca 1255921 ggccgcgcat gcctgatcct tttaatattc tttcttattg gcgaagttcc gccatgcttg 1255981 aaacggggat aaatgctctg ttagtgtcac ttgataaaag gggatcgttc tttcttcagc 1256041 aggtttatca atttctttat aaatgaatga atcatcaaac ccggcttcgg cagcgtctgt 1256101 gtgctcagct gcatagaaaa cggctttagg ccgggcccag tagatggcgc ccaagcacat 1256161 tgggcatggt tcacagctcg tatacaaaat gcagtcatca agctggtagg ctcctagcac 1256221 cttacaggct ttccgaatag ctgtgacttc cgcgtgggca gtcggatcat tgcttgttgt 1256281 gacgttgttc tgtccctctg caataatggc tccgtctttc acgataacgg ctccaaaagg 1256341 cccgccgatt cctgcattca ctccttcaca tgcgagagtg acagcccgtt ttaagaacgt 1256401 ttcatgattc atcccaatcc ctcctgtcaa tagagtgtta ttagtatagc cgaaaagaat 1256461 gcaaagaaca ttcttaaaaa agtgcaaaat aaacaaagta tttgggggat ttgctaaata 1256521 agaaaccgat tgtggctgta ttatagaaaa aaaccatctg ccaaatgcag atggtttttt 1256581 caaattatac tagctgtgtc tgctgtgctc ttgcctgttt tgcggcttca accatatttt 1256641 tcaatgctgc aaccgtttct tcctgctgtc ttgttttcaa tccgcagtct ggatttaccc 1256701 agaagcggtc agtcggacag acggcaagcg catcaacgat aatattgtac atttcttcag 1256761 ttgacggcac acgagggctg tgaatgtcat atacaccaag gccaagccct ttcaaatacg 1256821 ggtggttttt taagtaatct aaaaatcctc cgtggcttct gctatgttcg attgtaatca 1256881 catcggcatc aagatcattg attgtatcaa cgatatcttc gaagttgctg tagcacatat 1256941 gtgtatgaat ttgtgtctcg tttttcacgg aagaagtggt taatctgaaa gcttctgccg 1257001 cccaagtcaa atactcatcc caatcgcggg ttttcaatgg aaggccttca cgcagcgctg 1257061 gttcatcgac ttgaatgatt tgaatgcctg cgtcttcaag cgctttaact tctttgcgaa 1257121 gggcaagccc gatttggaag gcgatttctt tcctcgagat gtcgtttcga gggaaagacc 1257181 agtttaagat tgtaaccggg cccgtcagca ttcctttcac atgcttggaa gtcaatgact 1257241 gtgcgtagac tgtgtctttc actgtcatcg gttcaataaa ttcaacatct ccgtaaatga 1257301 ctggcgggcg gacacagcgt gagccgtatg attgaaccca ggcatattta gtgaaggcga 1257361 aaccggccag cttttcaccg aagtattcga ccatgtctgt ccgttcaaat tcgccgtgaa 1257421 caaggacatc aagctccaat tcttcctgaa tatcaatcca tctttttgtt tccgcattga 1257481 taaagttttg atactgttca tcggaccact cagctttccg ccatttttgg cgtgcgctcc 1257541 gcacttcagc agactgcggg aagctgccga tcgttgtcgt cggcaaaagc ggaaggccga 1257601 gagattcatt ttgtagggct aaacgttctt caaacggaat cgggcgcttg aagtctttat 1257661 cagttaattg ctcaagctct ttcttttgtt cagaattggc gcctgttgca aactgtttaa 1257721 gcgcctggat atcagcctta gcctgctgaa tctcttcgct gatcgccgct tttcctgata 1257781 ctaagccttc tttcaaagct gtcagctcgg ccagcttttc ttttgcgtag gataatccgt 1257841 tcaataggtc tttttccaaa tgctcatcag ggtgtttcgc tactggaaca tgcagcaggc 1257901 tgctggaagg ctgaatccac agttcatcaa cttttgcaat gctgagaata tcaagaacgg 1257961 catcgagacg ctcttcaagg tccgctttcc aaatgttgcg tccgtcgata acgccggctg 1258021 ccagcacttt atctgtcggg aagccatgtg ttttaagctg ttccaggttt ctgcctttgt 1258081 cgtgaacgaa atcaaggcca attccctgaa ccgggtaaga gatcagctct tcataagcat 1258141 caacagaatc aaaatacgtc tgcaaaagca cattcaagga tgaaagctca cttgtaatgc 1258201 tttcaaataa ttcttttgcg ccgcgtacat cttcactaga ggcggtaacg agcgccggct 1258261 catcgatttg aacccatttt acgccttctt cttcaagctc tttcaaaagc tgtacatata 1258321 atggcacaag gcgtttttgg atcgcttttg cttcagacgg ttcatagcct ttagcaagcg 1258381 taacgaacgt ataagggccg acaatcacag gctttgtttc cacaccgtat tcctgtttga 1258441 tccggcgata atcttcgagt tgtttgtttc ttgtcagacg gaactcaatg ctctcgtcat 1258501 attccggaac gatgtaatgg taatttgtat taaaccattt tgtcatttca ctagatacag 1258561 cgtctttgat tccgcgggcg atagcgaagt atgtatcggt agcgtcagtc aaatgtctga 1258621 accgtttcgg gatccagttg aagctgactg ctgtgtcgag tacatggtca tactgtgtga 1258681 aatcagaaac aggcacaaca tcaatctgct ggtcaatttg tgtttttact gcggataaaa 1258741 atagttcgtc gatttgcttc aaaaacgtat ctttatcagt actgcctttc caatacgctt 1258801 caagtgcttt tttccattcc cggttcagtc cgattctcgg aaatcctaaa ttcgatgttt 1258861 tgatggttgt cattgtttct cctcctttat atgtaaaaca ctctctttca cccgcggata 1258921 caggctgcta agaggttttc tcacaacaaa aagcctcttt cccatgagag aaagaggctt 1258981 ttctacgtaa aacactgcct ctctcatctc tcagacacaa tctgatggaa ttagcaccgt 1259041 gccttatgag acatcagtct cggcgcgaaa agcagtgcgc cccatttcac aatggtatta 1259101 cggtcggttg ctgttggggt caaaaggcca atccctcgcc caactctcga taagagaaaa 1259161 tgttattaat tttttgaaaa gttgaatcat ttgttggtaa tcttaacagt aattcaaatt 1259221 cattgtcaac atagaatttg aaatttttat ttacatgatg tggtgtatat tatataagaa 1259281 aaataatctt atagggtcaa caaatgtgat tgctctgctt tttctgcgag ctcatcagga 1259341 gctgttaaat acaggaatcc attgcctgcc agcgtttttg caatatcaag aggaagtgtc 1259401 ctgcggatta gctgtgcgaa aacctcagat tcagaaagct ttctttgaaa tgattcttct 1259461 tcatagcttt tgattaaagc aagcgcaccg ctgacatgag gggcagccat tgaagtgccg 1259521 gtcagcttac cgtacttctt gttgggaagg gtggataaga tgttttctcc tggtgccaca 1259581 aggtcaatct ctttattcgc gttagaaaat tctgataatt ctcgcgctac agaaacagat 1259641 ccaactgcaa tcacttcatt ataagctgcg gggtaggaaa gctcttctgt gcgttcgtcg 1259701 ccgtcacctt catttcccgc tgcacaaacg acaagcactc cgtttttcac tgcgtttttc 1259761 actgcttctt ttagctctgg cacatcgctt ggccctccaa gggacattga gatgatgtcg 1259821 actttctgtt ccaccgcgta gttgatgccg ttaattatcc attcgtattg tccgctgccg 1259881 ttctcgccgc caagaacctt cacaatcaat aggcttgcct caggcgcgac tccggcaatg 1259941 cctccgtttg aatcattagc tgcaattgtt ccggcgacgt gtgtgccgtg tccgttgtag 1260001 tcggaaatcg catcttcctt gccgccgtcg tcatccgtga agttctttcc gccgatgatt 1260061 tgatttttta aatcagggtg gcttgtgtcg cagcctgtgt ctaatacagc aactttaata 1260121 tttttgcctt ttaccccttt tgcccacatt tctggcgcct taatcacttt aatgccctca 1260181 ggaagctcgt ttacatccat gatctgctca ttcgtcacat acgggatcaa gcggatttca 1260241 ccattcataa aaaagccctc cttttttatg cttgcaagtg gattcaaggg tgttgcctca 1260301 tattatatga aaaaagcaag cgctcggaca gagccatttg aagcattttg aaaaaatagg 1260361 atacacacca aagaattagt aatcttcaaa atattggatg gcttcaacat gtatgactgg 1260421 gattcaactg taagtcaagt tataatagtg ttggggaaag gagcagtgtc atgaaactga 1260481 atgaaaaatt atatgcattt ttttcagagc atgtggaaca aatggccgag gaatggattg 1260541 aaacgatgga ggaaagtgat ccgaattcgc tttacgccct acataatgca acagtaacgg 1260601 aagaattgaa agagcaggac agagaatttt accggcatct gaattacatg tatgttttac 1260661 cggaaaaaca atttctcgaa gagtttcaag agtgggtcat tgagctgacc aacgatcaaa 1260721 aacatctcga cacaccggtt cagtatgtca ttcgggagtt tatgagaaac aggagattat 1260781 atacgaagta ttttgagaag ttcgcagaag aaaatgaatc agcgtttgaa ccgggagaga 1260841 agcaaaaatg ggcagatttg attgtaaaag tatttgattt caccatttat acattcgttg 1260901 atcacgctga aatgaatgcc aagcagcaat taaacgccca aagagaaatg atattggaat 1260961 taagctcacc tgtcattacc ctgagcaaat caacagctct gctgccgctt gtcggtgaca 1261021 ttgataccga acgggcgaag tttattctgg aaaacacgct tcaagcttgt gcgaaaagac 1261081 gtgtggagca tctgttaatc gatctgtcag gtgttgttgt ggtggatacg atggtggcgc 1261141 accagatctt taaattgatt gaggcgctta atctgatcgg tgtccggtca accctgtcag 1261201 gaatcaggcc tgaaattgcg caaactgctg tacagctggg gattgacttt tcgaatatta 1261261 ctattaaaac caaccttgcc caagcattaa actatcatca ataaaaaaat ccgctatctg 1261321 tgatagcgga ttttttatga tgcgaaacat aaagatacga gaaaggatcc cgcgaataat 1261381 aagaggacga ggcaaaagaa cacccagtcg cgccggttca cgctcaatgt cctgtagtat 1261441 gtccggtttc tgcttcctgt aaatcctttc gattccatcg caagcgctgt ccgttccgct 1261501 tttctgatgg cgcttgccaa tagcggtatg gtatatcgtt ttaacgcact gattttatta 1261561 atgatgccgc tctccgccgc tcctcctctg attttatgag cctgctgaat cagctggacc 1261621 tcatccttta acagcggaag aaagcgaaag cctgcaatga caccgtacgc gagctttggt 1261681 gagagcctgc actgctggac aaggctcagc ataaatagaa tcggatcggt tgtaaaaaca 1261741 aacatcatcg ataaggcgga aaagcataaa atacgaaacc cgagagagat gccgacagac 1261801 acattatcgc tgttaatgga gatagggcct gcttgaaaca aaaaattatc cggtgttgtc 1261861 ggcacttttc caaaaactgc ggctgtccac acgcatccga atgctaaaat caaaaacgga 1261921 atcgtaaaca acaaccattt tttcaatggg attccggccg ccagtaaaac gcccgcaacg 1261981 atgatgatat aaaaacatgc cggagtgtaa gggttgtaaa taaacgacag catgacgaca 1262041 caacaaaaaa ccgccgccgc tttcacagtc ggattaatga gatgtaacgg ttgcttcatc 1262101 acgcacctcc tcttgaaatg ccatccattc atatagaagg ggaagggtga gctttgcttt 1262161 ttgaacaagc cctgtttctt gagaaaacaa ctgcgctgga gatccgtcaa aggccaggcc 1262221 tgtatcgtga agcacaagca cgctgtcagc atacgaagag actagctcca tatcgtgtgt 1262281 aatcataagg acagcagttc cctctgcctt gatacgttga atcatttcca tgcattcagc 1262341 cgccgtgcgg gcatcctggc caaaggttgg ttcgtctaat aataaaacct ttacgtcatg 1262401 catgagcata gtagctacgc tcagtcgccg tttttgccct tggctgatcg caaacggatg 1262461 atgatcagcc aaatgcgcaa gaccaaaacg ctgcagcagg tgttgcgctt ttttctcagt 1262521 ttcagcattt gctttctggc cgaacagaag ctcgtcatac accgtatcgg tgacgaattg 1262581 atgctcaggg ttttgaaaaa caaatcccat ccgtttacgc aattcttttt ctttatattt 1262641 ctgcagcggc tgatcataga gaaggatttt gccgctttgc ggtttcatga gactggccag 1262701 aactgatagg agcgtcgatt ttccagttcc gttcggaccg acaagcgccg ttaaagagcc 1262761 ttcgcgcaac gaaaagctga tgtctttgaa aatcgcctgc tgtcctctcg cgaacgaaag 1262821 gctgctgact tcaagcacac tctccccaga aggggctttc ttctttttga catgcccggc 1262881 aggaataggc tctttgaaca gcatctcttt tgataaagta aacggcatac tcagcttttc 1262941 ctgcagatga cagacctttg gaatggcgat gcccaatttc tttagtgtct ccgcttcatg 1263001 ctgaaataga tttttcgtca ggccatccag tgcctttttg cctgatttgt cgagtacgat 1263061 cgttctctca atccaaggcg cccattcatc aagctggtgc tcaatgacga ggaggctgaa 1263121 acctttttcc cgctgaagat ccttcatcag atgaacgaac tcccgagctg agaaagggtc 1263181 taaaagagag gtcggctcat ctaaaataat aagctcaggc tccatcgcca aaatacaggc 1263241 gagagccact ttctgctttt gtcctcctga aagggttgag atcatttttt cttttaaatg 1263301 ggtaatgcgt aatttttcta atacggcgtt gattttctct gtcatttctt cttttggaat 1263361 ttgcagattt tccagcccga acgctatttc gtcctccacc gtcagcatgc agaactgctg 1263421 atcaggatcc tgaaaaacga ccccggcatg ctgagtaatc gtttcggagg tttcagcatc 1263481 tgtgaccggc ttttgaaata gaaatacatg tccggactga atgccgtcgc aagcctccgg 1263541 atatagaccg tttaaacaaa gggcgagcga gcttttaccg catccgctcg gtcctaataa 1263601 taaaacacat tctccttttt gaagctcaaa cgaaatgtct tgaaaaaccg gtttctcgtc 1263661 ttcttcataa gagaagctga gctgctcaac cgtcagaagc tcatcaaagg cttgcatgtt 1263721 ctgacgcccg cttccgtttc tttttcagtt cctttccgag tgccattccg tttaacacac 1263781 ctgtataagc gagagagtcg ctgacagctt ttccgagaag ccccgccaaa agcgcgccgg 1263841 aaatgaggcg gatcacaagc ataatgagca gataacctgg tgaataggct gcatagccag 1263901 aaacaaagag atcatagata aagctggcta ctgaagaccc cataccggcc agcataagga 1263961 cagggagaga gtatgctttc cagcgtgttg caagaaatac agcctcagcc ccgagccctt 1264021 gaacaatgcc aatgacgatg accatcgggc cagacggatt tcccagcagg cactcaacga 1264081 gagcggcaat gatttcagaa acgagcgccg cacccggttt tcgaatcatg tacgcggcga 1264141 tcacagaaac gataaaccaa atgccgtaaa ttggttcata ggcgattggc ccaaacatac 1264201 ctgcaagtac gtttccgaaa tgtgtaaata ataaataaac aacggcaaat acgatactga 1264261 taacggacat gatgacaatt tcttttactt tccagctttt catgttatcc ctgctttctg 1264321 ttttttcttg atggactgtt agccgaaaga ttcacagtca tggtgatgtg gtttgtttgc 1264381 tgctcagcca tgcggaaaac ggcctccaat gtgctgaata cgtcatgcgc atccccgtca 1264441 agctcgctcg cgtaatggac accctgtacg aaagtgcctt gggcttttgc aatgtcgaca 1264501 gcctccataa tcaatcccat ataatccggc tcattcattg gataaagggc aaattggcac 1264561 ggcgcttccg ccttcaagcc tcggacagca tcttcattga cacgcttatc acctttggaa 1264621 agatatgtat ccccctgtgt gtcacccggg catccaatgg aaaacgtgcc gttcatgacg 1264681 atgtgttgtt cgctgtttgc tgcatgaagg taaatggctt ttgcagcatc gaatacatga 1264741 tcaatcgatc cgcgtaacac cgtgctgata tggtcggttt tcgtccaaac cttggatgta 1264801 tctgtttttt tcagcgcaga cttgatcaca ctgataaaat catccgtcat cggatataaa 1264861 gagaagcgaa aaccggcgat tctgcttgta ccgcaaatat gctccatttc tccgacctcc 1264921 tgtttttttg gtaaaataaa aaactgcata tcctaaggga atatgcagtc atagatcgat 1264981 taagcgcaca aaaaaataca ccattcggtc aacctgcact tccccacgct ggtattatcc 1265041 agatcgggtc ataagggatc aaagcgcgtt tcttccgcgc tttatctcag ccaaaacagc 1265101 acccctagtg ctttccgtat acaatttttt attttgacat cataatagat gataagaatc 1265161 attttgtaaa caacgaaatc atttttttca tatagggacg ggagaggatg gtcaaatttg 1265221 gaaaaaggac acatattaat tgtggaagat gaagaaaaaa tcgccagggt tcttcagctt 1265281 gaattggaat atgaaggata cagcgtcacg atcaaacaca atggcacaga aggtcttgat 1265341 gcggcagcgg aaggcgggta ttccttggtg cttcttgatg tcatgcttcc ggggcttagc 1265401 ggactggaag tgctgcgccg cttgagaaaa acggattcgc agacaccggt catattatta 1265461 acggcgcgag acagtattcc tgataaggta acaggtctgg acatcggtgc aaatgactat 1265521 gtcaccaagc cgtttgaaat cgaggaattg cttgcgagaa tcagggcggc gctgcggcaa 1265581 aatggaacaa aaactgaaga tatcggcacc tttcttacat atgacgattt gcgggtgaac 1265641 gaaaaaaccc gtgaagtgag acgcggagac aaagaggtgg aattaacgcc gcgggaattt 1265701 gatctgctcg tctatatgct aaagcatccg cagcaagtgc tgacacggga gcaaattcta 1265761 agctcagtat ggggatttga ttatatcggt gatacaaatg tcgtggacgt ctacataaga 1265821 tacatcagaa aaaaactgga ctatccttac gaaaaacagc tgatccatac gattcgcggg 1265881 gtcggctatg ccattaaggg gtaaacgatg aagctgaaga ccaagattca tctatacact 1265941 tcgatatcac tgttgatttt attaattttg gttcataccg cagtatatct cattttttcg 1266001 tctgcgctga catcaaagga tgcggcccgg cttgctgatg agacggataa cattgccgaa 1266061 gcgctgcgtg ccgctgaaac agaaggagtg gctttgcagg atatgctgca ggcctatctt 1266121 ccggcaaatg gcatggtgcg tgtagtgaat ggtgatcaaa aagccgttat gacgatcaca 1266181 aaagaaaaag cctataaaga ttttcctctc tcttttcata gcggcgaaac ggcagatgtg 1266241 aggaaacctg acggcaagct gtttgccgag gctgctgttc cggtgatttg gaccgatgga 1266301 caagtcgtgt ctcttcagct ggttgaaaga ctggagaaca cagaagagag tctgtttctg 1266361 ctgaaaatca tcttaatcgc tgcaagtgct gctgtctgca ttgcttcttt ttttgcaggc 1266421 agcttgctag cccgccgaat catcaatccg atcagacgat taatgatcac aatgaaagac 1266481 atacagcgag acaaagaatt taaaacgatt tctttagaag gacagtccaa cgatgaattg 1266541 tatcaaatgg ggctgacatt taatgaaatg gcaatgatgc tgaaggagca ctatgataaa 1266601 cagcagcaat ttgttcaaga tgcttcacac gaattgaaaa ccccgctcac tattatagaa 1266661 agctacagca gcctgatgaa gcggtggggt gcaaaaaagc cggaggtgct tgaggagtcg 1266721 atagaagcca ttcactcaga agcggtgcat atgaaaaaac tgaccaatca gcttttggcg 1266781 ctggccaaaa gccatcaagg actcgaggtt gatctgaaaa caatcgatct gattaaagcg 1266841 gcgcgcgcgg ttatgcaaac gctccagtcc gtttatcagc gtgacatatt gcttgaaaca 1266901 gataaagaga gcctgcttgt aaaggcagat gaagaacgca tcaagcagct gttgaccatt 1266961 ttgcttgata atgcaataaa gtatagtgaa aagcctattg agatgtcagc cggaacgagg 1267021 aatggacggc catttctatc agtgagggat gaaggcatcg gaatacctga ggagcatatc 1267081 ccgcatttgt tcgaacggtt ctaccgggca gatgaggcac gaaacagaaa aacaggcgga 1267141 acaggtttag gcctttccat tgccaagcaa atcgctgatg agcatggcat tgagctgtct 1267201 gtcaaaagca agccgggaca aggaacagct gtcaccatgc aattcagcga acagaatggg 1267261 ggaggccgat gactaaaaca ataaaaacag tatcttttgc tgcagcagcc attttagttg 1267321 tcatcatctg tacgtttctc atcattcggc aaacccatga gaacgtattg tcaaaggaga 1267381 ctgtcgtaaa aaaagtcgaa gcctcttatg aaggcaaggt cacgaaagca acacaatcaa 1267441 aggataaaaa aacatatgat ataacccttg aaaatccaaa gggaacttac tttgtaaaag 1267501 cagacgcaat atcggctgac attctttcaa tgaatagagt aaaagcagtg aatccatctg 1267561 ccatgacaga aaaagaagcc gagcatctcg cgcttgagcg ggtgccggga acggtcaaaa 1267621 aacaaacacg gcaaagtcaa gttgccactt ataccataca aaaagaagac gggaaaacat 1267681 acgaagtgaa ggtagacatg caggcaaaaa cagtcttgtc tgccgatcaa atcagcagca 1267741 aagatcaaca aaaaacgccg attacgaaaa aagaagccaa aacaattgca gagcgaaaaa 1267801 cgggcggaac agcggatgac gcagatctcg aagaaagtga gggcactctc atctttgaag 1267861 tagacgttga tcttcctgat aataaggaag cgacagtgaa aatcaatgcc tacacaggaa 1267921 aggtagctaa cattgtgtat gaagactgac ggtttctcat caaattctca tcttgctctc 1267981 gttttccttt catgttgagt atgtaaactg tactcataca aaacaaagga gggctcacaa 1268041 atgctcaaga aaaaatggat ggtcggtctt ttagcagggt gcctagcggc cggaggattc 1268101 agctacaacg cgtttgccac agaaaacaat gaaaacagac aggcttcttc taagacggat 1268161 gcactcactg aacaagaagc agaagcaatt gctaaaacag ttgttgacgg cacagtagaa 1268221 gacattgaca gagaccttta caacggcaaa gaagtctatg aagtggagat tgaaaaagaa 1268281 ggtgaagact acgacgttta tgtagatatt catacaaaac aagcgcttaa tgacccgtta 1268341 aaggagaaag cagaacaagt cgccataacc aaagaagaag ctgaagaaat tgctttaaag 1268401 caaacaggtg gaaccgtaac agaaagtaag cttgacgaag atgacggtgc ttacatctat 1268461 gaaatggaaa tccaaacgaa gcaaggaact gagacagaat ttgaaatttc cgcaaaagat 1268521 ggacgcatta tcaaacagga gatagatgac taatcaaaac ccccgctgca gcgggggttt 1268581 ttcatgataa gaaaccttct tttggacaat ctaagtagaa aaggaggcga aacgcatgga 1268641 aaagaaagag gagcaataca tcaatcaggc tgaatatgtc cctcatccga cgaaggaagg 1268701 agagtatgcc ttatttcttc atgaaacgta tcatttgctt tctgaagatg acgagacaca 1268761 aacaacagaa taagggctta ggcccttgtt ttgttccgta attgtgatgt aagcgcattt 1268821 attacttttt tgagttgaca tagcttgttt ttttctgtaa tctcagtgtg tcaattcaat 1268881 taggaacttc gttaggtgag gctcctgtat ggagatacgc tgctgcccaa aaatgtccaa 1268941 agacgccaat gggtcaacag aaatcatcga cataaggtga tttttaatgc agctggatgc 1269001 ttgtcctatg ccatacagtg ctaaagctct acgattgaag gcgcccgcac gctttttttg 1269061 ccgtgcttct ttcaccttca atcccgaagg ctttttttat gcctttaaaa cgaaaccaat 1269121 caaaggaggt gcggagtatg gattctcccc attcgagtca atctgaagaa gtacccatat 1269181 actatgacag caagacaatt gattacacga tgaggagacg aactgccgca ccttctggcg 1269241 aggccggcac gtctccgtag aggaggtacg agtcccgatg gttcaaaaca tgacctatga 1269301 cgaactcatt ttacgcatca ttattttact gcgagacggg aaaatcaggg attttagaag 1269361 tgttattgat gagcttcagc cctatgacat ggcatttatt tttaaagaaa tgccggaaaa 1269421 acatcgcgcc cgctatttat cttatttaac tgtagacgat atcactgata tgatcgggga 1269481 gctggaacgc gaatttcagc ttgtcgtctt aaataaagtc ggaaaaacaa aagcaacact 1269541 ggcgatgaac aaaatggaca acgatgacct cgctcaattg cttgaagaaa tggacgaaga 1269601 actgaaggaa cagcttttat ccagcatgga agcgtcagaa tcaaaagctg tacagctctt 1269661 gatgaattac ccggctgatt cagcgggacg catgatgaca aaccggtatg tgtggatccc 1269721 tcagcattac acggtaaaag acgcggtcgt caaactgaaa agcttcgctg aaatagctga 1269781 atcgatcaac tacttatatg ttattaatga aagcaaacag ctggttgggg ttctttccta 1269841 ccgcgatttg attctgggtg aacctgaaga aaaggtgcag gatttaatgt ttacccgcgt 1269901 catatcagca gatgctcttc aggaccagga agaagttgcc cgcctgatag aacgttacga 1269961 ttttttggca ataccggttg tagaagaaaa caacgtgctt gtcggcattg tgacggttga 1270021 tgatattatc gacgttgtta ttcgggaagc tgatgaggat tacgaaaaat ttgccgcttc 1270081 cggtaaagac atcacctttg acacaaaagc ttacgtggcg gcataccggc gtctgccatg 1270141 gctgatttta ctcttattta tcggactgat ttcaggaagc attatcagct attttgaaga 1270201 cgcgctgaag caggttgtcg cgcttgcgtt tttcatgccg atggtgtcag ggatgacagg 1270261 aaatacggga acacaatctc ttgcggttgt catcagaggt ttgtctaaag aagaaatgaa 1270321 caaaaaaacg attgtgcgcc tgatcttccg ggagttcaga acaagcattt ttatcggagc 1270381 ggtttgttct gtgctgattg cgattgtttc tatcatatgg caggggaatg cgcttttggg 1270441 atttgttgtc gcctcttcac tgttcttaac cttaatcatc ggcacgatgt caggaacgat 1270501 tatccctatt attttgcaca aactgaaagt agacccggcg attgcttctg gaccgctgat 1270561 tacaacgtta aacgatattt tatctttatt aatctacttt ggcattgcca ctgcattcat 1270621 tcactcatta taaacgtaaa aagtccgtct caactgcgag ccggactttt attatttaac 1270681 ggtttttgta ccgaaagtga gcattaagct gcccctccag catttttttc cgcacttgcg 1270741 gatcgttttt taacatctgt tcttttttgc gcatatcctt taaaatctct gccgtctgta 1270801 cgccgtcttc acgcttattg gcgatatcca tcagccgctc cacatcggca aaggagtatt 1270861 ttcttgtccc ccttgaagaa cgctgcgggt aaatgagctt tcgttcctca taatacctga 1270921 tctgtcttac ggacaatcct gtcaattcac tcacaattcc gattgaaatc acttttttgt 1270981 ctttataaga atgatcttct gtggtcattt ttccacccct ggatgtcttt tgataatagt 1271041 atataaaaaa caaagagaaa aaacctgacg cttgtcatat tttctaacat caaatagaag 1271101 atttttgaaa aaatacggaa gaaaaattaa caagaataat gcgtaacacc caagcgcgtt 1271161 ttatccttta tgtaacgaat caaacgagga ggaaggataa tcatggagga agaaaaagca 1271221 gtctcactgg caaaagaaat tatagagttg gatatcaagc gtgatgaaat gctggagacg 1271281 tttatgcagc ttgccggaga acaggctttt caattattaa gatcggttca aaacggacaa 1271341 taccgaaaat cttcgtaaac ataaattctt tacattagat tcataccacg ttcatttaaa 1271401 aagagtatct tttgtatagg atacctcaaa atgaaggagg acgctatgag taatttattg 1271461 aaatccgctt tagaaaaaga acgacgccat tattctgaaa aactctatca gataggggtt 1271521 tataataaag aggtcatgaa caaaatgacg atttctgagc ttcggaaaga atacgcttat 1271581 ttctttcgaa gcattacaaa tcataaaaat tatccttata caagataatg tataaggatt 1271641 tttttgcttt tagaaggaat ttctcgaatt atagcgaata cgtatagtaa gggactgaac 1271701 tcttattata tgtaagggtt ttcattattt ttttataaaa atcctatata cgaggtagat 1271761 atgatgagat tatcgtttaa cgaagaagaa gttgagcgtg cgatgaattt gtacagagtt 1271821 tttgcaaggg ctttcaaaag tgtgtccgaa catagtatcc gtgatagcaa agagcacggt 1271881 tttaatccca ctgaatttgc tgtactggaa ctcctgtaca caagaggccc gcaaaaatta 1271941 cagcaaattg ggtcgagact tctgcttgta agcggaaacg tcacatatgt tattgacaaa 1272001 ctagaaagaa acgggttttt agtaagggag caggacccga aagataaacg ctctgtttac 1272061 gcacatttaa ctgacaaggg aaatgagtat ttggataaaa tttatccgat tcatgcactg 1272121 cgtattgcga gagcgttttc aggtctttcg cctgatgaac aggaccagct gatcgtcctg 1272181 ctcaagaaag caggcataca cagccagcat ttgctgtttc gttaactatt ctacactctc 1272241 tatttcagga gagtgttttt ttgtttccat atgattcttt ttaaaacatc tttaatcttc 1272301 ctatcagaca tttcgccaag gtatccattg acgtgttttt tatactcctt catctgttcg 1272361 ttcgattgaa aaaatgccgc gatatactct tctgctttct gcatgtccca gtttctcata 1272421 tctgtgacga gtttcctttc atgtagaagg tttaaattca tttcctcctg tcccggcagt 1272481 gcatgataaa taaataccgg aagccgtttc tgtaagcatt cactgatggt cacgcctccg 1272541 ggtttagtca tgatgcctgt cgcctgttcg tacaaacggt tcatctctgc tttgctgtga 1272601 aggtaaggaa tcgcctcaat caaggggtgg tgtaaacttt tgacatagga gtagagcttt 1272661 tcgtttctgc cgcataatat tttgtataag atctttccgc ctggcgacag ttcctgcacc 1272721 cattttaaaa tcccaccgac ccccatactg ccccctgtga tgatgatggt atatggcggg 1272781 tggtgctgca aggtatctgc tgattccatt tcaaaatttt ggtgaactgg aatgccggtc 1272841 aagtatatgt tgttctgatc gataccctct gatattagct gcttctttac ttccgtgctc 1272901 ggaacaaaat ggtaatcaat gttcttccgt ccccataatt gattcacgaa aaaatcagtg 1272961 tatacattca caaccgtcag attcggatat tcaggcttta gtcggttcag cagataagaa 1273021 ggcagcgcat gtgtgcagaa ggcgatatca ggctgttttt cttggaggat gtgcctcatt 1273081 tgctgtgtga acagccattc gtacatgaaa tagcgtttgt catgctgaaa ttctccgcag 1273141 gcgaggagcc tgtaaatgcc gctgtacgtt ttcgggaaat attgaatcca ttttaaataa 1273201 gccacggagg acaatttttc taaccgccta tacgaatgtg aaaagatatc aatcttttca 1273261 gctgccagcc cttgagactc taattcagcc tgcaatgcat cagccacatg atgatggccg 1273321 gtggaaatgc ttaaaaaagg aaaaatgaga atgtttttca tgacagtcct cctaaaaaaa 1273381 tatggcaact atattttgag gagaacgttc acaaaatata agggtgtttt tgatcataag 1273441 gaaggtgaaa agatgaaaac ttgtttcctt tccatatgga gagtggttga tccgatttat 1273501 ttcttttttt caaggctaag cttgattgac aacgatcaaa aaagcgtttt tcgagtcagg 1273561 ctgacgaagt acaaaggaca tcatgtcgtg cttagcgacg gaacgcatat aagaaaaaat 1273621 gatgtgctcg ttaaaatcca cctgcataac ataaagctga tcagggagct gcaaagcatt 1273681 gagagcgcag tcagaaaggg aatcattatt tatcagaaag tatatcaatc gatgccgctt 1273741 cttcttgact atatcaacaa tcataaaaaa agcgagaaaa tcaaaggaat cattgggatt 1273801 acaatgcttg acaaaggtgt ggaaaggctc ggctttgatg tgatcacccc ggtgaaccct 1273861 ttttacagat gctttaaaaa agtgtctcat gtgccgattt tatatttgac ttcaaagcct 1273921 gtgagcttgc ggcatttacc gaattcatcc tatttgttta tctcaaaaga aaagctgcag 1273981 aaaacctatc aaaaaaaaga ctgatgcctc ggtcagcaca gtcttttttg attaaatctg 1274041 atgaaatgtc acttcagggc ggcttccgac acggatattt acgccggttt gtcccaagcc 1274101 ctcgctgata taaaatggtt tatcgtgatg ataatgaagg cctttaatca tgttcattcg 1274161 cacgagcttt cccattttca ccaaatgata cggttttggc cagtgaattt gcccgccgtg 1274221 aaaatgccct gacagcaggt aatcataatg aacatctttc atatccagaa taatatttgg 1274281 gtcatgtgtt aagacaagat gatagccatt ttccagactt tgataagagc cggtgatatt 1274341 actccgattc gtactgtaat catcaatgcc gataatattg actggtcctg cagccgtctc 1274401 gattcgaaca tgttcatttt gcagcgtgat acagccgttt tcctctaaaa ctcgcttcaa 1274461 tctctgaaag tcctcttctt tcaatacata atcgtggtta ccgaacaccg cgtacattcc 1274521 atatgcaggc tttagctttt gcaaggcgtt caagtaacct gccagtttcg gaatattacg 1274581 tttccgatca agaaaatccc cggtaagagc aatgatgtcc acaggctgat cttttgttaa 1274641 atgatacagc tcctcaggtg agactgaaat gttttccaag tgaagatcag ataaatgaag 1274701 gatatttaat ttttttctgg ctggaaggcc gtctttttgg tcgattgaaa tggtgttgac 1274761 tttcacatct tttgtattgc ggttcgcttt atatagaaat ggcacaaata cgagtatggc 1274821 caatgaaagt aagattgtaa acaaaatata tcccctccct tctatcagta tagtaagtga 1274881 tcaagcccta tggatagcgg gaattaatgg gtagagacag gttgaaaaac ggattgtcat 1274941 atgatgaatg atttggaagg gaaaagggat aataaatttt gacacatgag gcagaacatg 1275001 ccgacggagt cagaataaca aatggatgtg taagcaatgt tacgattgat gagacaacaa 1275061 aaaaaagaaa catattatct ctggatcgca ttatttcttc ttttattgta tgtatccccg 1275121 ctttttattt taaaggaaga tgcccatatc cgggtccacg ataatttaga ttccaacatc 1275181 gcttggtaca aggttctggc cgatagcgga gaaatcgtcg gcaaggttga cgctgccatt 1275241 ccgcaaatca ttaacgggct gccccgggat gcctttggca ccgagtggag cggaattgtt 1275301 tggctccatg ctttcttttc ttccatgacc gcctatgcaa taagccagac ggttacaaga 1275361 gttgtcgctt tttttggaat gtatgtgctg ctgaagaaac atataatccc ggaaccaaaa 1275421 gcggctttca tccgaattgg cgtatcgctt gcatttgcct taacaccgtt ctggccttcg 1275481 ggaatgctga gtacgcttgg gtaccctttg gcactgtggg cttttttaaa tatccgaaaa 1275541 ggggatatct catggagaga gtggctgacg ctgggcttgc tccctctata ctcaagcttt 1275601 gttctaggct tcttcttttt cctggcaggg atggcgtgtt tttggctgta tgatgccatt 1275661 acaaaaagaa gatggaattt gatgttctta ggcagtattg catttatgac gagtatctat 1275721 cttttcgttg aatatcggct tgtctattcg atgctgtttg agcacgcacc gatgcatcgt 1275781 atcgaattta tctcatctag gcatgacgtt tggcattctc ttcgactatc cataaaaaac 1275841 tttgtctatg gccataatca tgtgatgacc gttcataccg ttgtcatcct tccgatcctg 1275901 atggtcgtat ttgctgctct gctgttcaaa cgaaatcgga caaagccaga aaatgtttat 1275961 ctgtttttat gtgtgcttaa ttacgggttg tcattatggt atgcgttttg gttcaacaaa 1276021 atttgggctg ttccaaagca gaaatttgct tttttagcag aatttaattt tgcccgtttt 1276081 cattttcttc ggccgcttgt tatatacgtg agctttgcgc ttgctttata tctcatttgg 1276141 cggatgggga aaggatggaa atggcttgtg tacgccgcag tcgctgcaca gctgatggtg 1276201 ttggcgcctt ttaatgaaga atatacgtat ggtgttcatt acaacgcgcc gacattcagg 1276261 gagttttatg catcagagca attcaaagag attaaggaat atatcggacg tccgcaagat 1276321 tcgtataggg tggcgagcat cggactgcat ccgtctatcg cccaatataa cgggttttat 1276381 acgttagata cgtataacaa tctgtatccg ctctcatata aatatgaatt tagaaaaatc 1276441 atcgaaaaag agctggaaaa aaattctcgg ctgaaacaat actttgatga atggggcagc 1276501 cgctgctacc tttttgtcga tgaactcggt aaacgatatg atttcaaaaa gaactcgaag 1276561 aaaacgatca acaaccttca attaaataca gatgtattta aaaaaatggg tggacggtac 1276621 attttttctt cagttccgat catgaatgct gaacaaaacc atctcgcgct cgtaaagacg 1276681 tttgaccata aagattccgc ctggcgcatt tatttatatg aaacaagata aggaggatat 1276741 cgattgaaac agtcacagcc agtattaacc atcgtcgtcc cgtgtttcaa tgaagaggaa 1276801 gtgtttcaag aaacaagcca tcagctgaca gaggttgtag atgatttaat tgaagaaaaa 1276861 ttaattgctg aagacagtaa aattctgttt gtcgatgatg gcagcaaaga ccgcacttgg 1276921 gctttgattg ctatggagag cataagaaac aagaaggtta ccggcttaaa attagcctgc 1276981 aatgtcggcc accaaaaagc gcttttagcc ggattgcata aagcgaagaa taggtcagac 1277041 tgcgtcattt cgatcgatgc tgatcttcag gacgacatct ctgtgatccg ggattttatg 1277101 ctgaaatatc atgagggctg cgagatcgtt tacggtgtac gccggagcag aaaaaccgat 1277161 acctttttca agcgcacgac cgcgttaggg ttttatcgtc tcatgaataa acttgggatt 1277221 aaattaattt ataatcatgc tgattttcgt ttaatgaata aaaggtccct tgaagagctt 1277281 gagcgttatc cggaagcgaa tctgttttta agaggtattg tccccatgat cggctttaaa 1277341 tcggccgaag ttttgtatga ccgcaaggaa cgctttgccg gcaaaacgaa atatccgctg 1277401 aaaaagatgc tatccttcgc ttttaacggg attacttcat tcagtgtcgc accaattcga 1277461 ttctttacgc ttttagggtt tgttttgttt ttcctcagcg ctgtggcagg gattggcgcg 1277521 tttattcaaa agctgctcgg ccatacgaat gcaggctggg cgtctcttat catatccatt 1277581 tggtttttgg gcgggctgca attgatggga attggaatca tcggagagta tattggaacg 1277641 attttttctg aagtgaaaag acggccgaaa tacgcgattg atattgattt gtataatgaa 1277701 cagctgagcc cgcttcagcg ccaggaaaaa gagcggttag aaaaaaagta cagttaaaca 1277761 cggaaagagc tgacttcatt agtcagctct ttttcttcaa ctgatgcaat atagcgctaa 1277821 gcggttcgtc ttgcgggttg cggtaaaaat caaaaaatgg gcagccctgc ttcttaattc 1277881 gatcgatgac cgtatcaatt gtaaacagag cgggtgttaa agatgattgc acctcatgcc 1277941 agtagagcgg ggctgcaaca gtcccaagct catttcctct cgttgaatag ggacagataa 1278001 tcgtttttcc ttctgcatgc tgcaaataat caagatacaa tttgcagtgt ctgtttttaa 1278061 tcaagcgttc agtggtaaag agctcgggaa atgcattggt gcagtactct gcgatcagct 1278121 gcgtaaattg gcgtgtttct tcatacgtaa atgcctcggg agacaaggga atataaagct 1278181 ggatgccttt gttgccggac agcttcgggt acgatgtgat gccaaaggaa tccaacagcc 1278241 gcttcagttc atttgcggcc tgcacggcca taagaaagtc atctcgcgaa ggcgggtcta 1278301 aatcaatgac aatctcagcc ggacgcctgc ttttaatggt ttgaaaagga acgtgaaact 1278361 ccaaagcaag ctggttgcaa agccatagca atgtagacat atcctcacag acaatatgtt 1278421 catggcttcc atcatagaaa gactgaacaa aatccggcgc atagtccggc ttgttttttt 1278481 ggaaaaatga ttcgctccta gatccatgcg gatagcggat gacggtgaca gcccggtttt 1278541 tcagaaatgg gagcaggtag tcactgactt caatcatata ctgaataaaa tcttcttttg 1278601 tttttttatt cttttcaaat atgattttat ccaggcttgt gaactggagc tttgggtgaa 1278661 ccggtttgga gtgtcgtatg acttgcgcat acgtgcattc ggtccagtcc atttggaatt 1278721 cgaaaccgat aaacgatacc tctcttaatg tgccttggag aattgttaag tattgaacag 1278781 ctgcacaaat cgaaggttca agcgtaaatt cgcctgaggg tgtttgatgt ccgtgctgtt 1278841 ccataatctc gcgtatagcg cttttttcct catcacgcat tccgtgcgag acagaggcaa 1278901 tcggtgtcat tattccgttt tttaacaccg ataccgtcag aaacccgttg ttagggttga 1278961 accctgttat gcaaacataa gcttgtttaa agtttttata tttgagccaa tcggacgacc 1279021 gcttcttttc aagccatttg ctgtttgttt tcttcgctac aattccttct ccgtcatatt 1279081 ttattaccat ctcccagagt tgatcaaaat gatcataaca gggaatggat tgaatggttt 1279141 cttttgcgta aggatctgga gatgcaggaa gctttgctgc ggatatgagt tcacgcagcg 1279201 attttttgcg gtccaaatac gaaagaagcg ttacatcttc tccgcttcgc tctaacaaat 1279261 caaaggcgag aaagcagcac ggccgcgcgt ttgccgattc ctgaatcttg tctggccttt 1279321 tcaaacgccc ccgcacttga aggtgttcaa aatctgcacg acagggattc accaaacata 1279381 cgatttcacc gtcaagtgtc agcggaagct ctttttctag gtgctgaaag gcagttttgg 1279441 cgaattgtgt gatttcaggg aaggtgctgc tgagctccac accatttctg ctggttaagg 1279501 tcacacctga agaatggatg cggagaatac agcggtaccc atcatatttt acttcgtaac 1279561 gccattctgc tccgattggc ggtgacgaag ttaagaccgg ctgcatggta aacgccatgc 1279621 gctatgatgt gccggaggct ttttttctag ttgttttttg ttttttatct ccggctcctt 1279681 tcggttcagc ggcttgtgca ggtgcggcag ccggtgtctc ccggttcggc cttctggttc 1279741 tgtcgatgct ggcttgcaga gcgcttacca ggtcaatgac atcttcacga ggtggcgctt 1279801 tatcaggagt gacagccgtt tctttatttt ctagcttgtc gttgactctt tgcagcagcg 1279861 cctgtcggta cgtgtcttca tatttctcag gctcaaactt agcagtcagt tcatctatta 1279921 atgtgatagc agtttgcagt tccttatcgt ttacattcga ttgatcaggt acacctggga 1279981 cttgagcggc gcttctgacc tcatcgggat aatggataga ctccatgacg atacaatttt 1280041 cataaacgcg gagaatcgcc agctgctgct ttgacctgat tgtcatattg gcgataccga 1280101 tctttccggt tgagcgcagc gcctcacgca gcagggtata ggccttcgtc ccattatccc 1280161 cggggccgac aaagtaggag cggttaaaat aaatcggatc aatttcctga agctgaacaa 1280221 agtcaacaat ctcaactgct ttctcctcat gctcctgttt taagcttttt aaatcttcgt 1280281 ctgtcagcac tacatatttt ccttttacat attcatatcc cttcacaatt tcatcaggac 1280341 taagagtttt ttcgcaattt gtgcaaactt tctcgtattt gattggtgcg tgatcctctt 1280401 tatggaggct gcgcagttta atatctttat cttctgtggc cgcatatagc ttgatgggga 1280461 tgtttactaa tccgaagctg atcgatccct tccacattgt atgcatatcg ataaacccct 1280521 ttttttcttt agtgtgaaga gaaggagtac gattcatgtg tagtaactta tgggtgaaaa 1280581 aaagccggcg ctgttattgc gacggctgtt caataatgaa ttgttcgaat tgttccggag 1280641 gtattggcct gctgaaaaag aagccctgca aatggtcgca gcctttttca aaaagaagct 1280701 gcttttgagc tgcattttcc acaccttcgg caatcacctg caaagacagc tgatgcccca 1280761 tggcaataat agctccggta atttgctctg atttaggatg ggtctgaata tcgtcaataa 1280821 atgatttgtc aatcttcagc ctgtgaatcg ggaagtcctt caaatagcta agagagctgt 1280881 gaccagtacc gaaatcgtca atactgattc tgattcctaa ttctgttagg gatgacaaaa 1280941 cctttttgga gtgattgaga ttgtccattg tcatgctttc cgtcacctcc acttcaagaa 1281001 gctgcggagg aagctggtac ttattaagcg tatccttgat gaggggaatc agatctttag 1281061 attgaaactg tctggcggaa atattaatgg cgacagaaag atcatagcct ttgtcatgcc 1281121 aaatccttgc ctgcttgcat gcttcatcta taatccactt tccgatatca ataataagtc 1281181 ccgtttcttc tgcaacaccg atgaattctc cgggcggacg cagttgcccg tctggtgtca 1281241 caaggcgtat cagtgcttct gctcctgtca ttttttgttt tttcacactg aattgcggct 1281301 gataatgcaa gacaaatcta tcgttttcga ttgcttctct gagtaccatc tcttggttaa 1281361 gcttaacggt ttctttgttg ccgattgaaa aagaatagta tctgtatttg cttttgtttc 1281421 gttctttagc cgcatacatc gccatatcag cctttttcat caattcaagg ccatccgtcc 1281481 cgtcttttgg agatatcgca atcccgatac tgacagatgt gacaagggtg tgatcttgaa 1281541 ttttgaaagg ttttttgaat ttttggataa tttttcttgc taaaacatct gcttcgcctg 1281601 ttcctgtatt ggcgtctgtt aatataataa taaattcatc accgccaaga cgggcgataa 1281661 atccgttatc agggactaca gatgacaggc gtttagctgc aaactgaagc aattgatcac 1281721 cgacattatg ccctaatgca tcgttaatca ctttaaaccg gtttaagtca agaaagaata 1281781 caacagtgtt ataatgcaag gaatgctcgc gattcagcac ctttgttaga tgagagatgg 1281841 catgccttct gttaggtaag tctgtaagcg aatcataatg agccattcta tggatttctt 1281901 tttctgcttt gtactgcttc gtcatgtctt tacaaatgac ataaatgctg tctagttcct 1281961 gattgacctc aacaggtata agcgtaatat ttaagtgaaa ctggcctttt tcagtgataa 1282021 gatcgctatc gctgttcatc gcttgtttat cttttttaac ttgctcaaaa aggcgcttaa 1282081 ccttcagtga tgtgtaattc ctccagtcat gcatgctgaa gccaaatttg ctgatcattt 1282141 cctcaccagc gtgattggaa gatattatgt ctccttctaa tgataaaata aaaattgcat 1282201 caatattgtg gacgattaaa gactgaaatc gctgttcgtt atcctttatg cgttcgctct 1282261 gtttaataaa ctttcgatct gcatgggaac tgaataacaa taacgtttgg atacaaaaaa 1282321 taattaaagt aacaaaaatt gaccaatgaa acgtttgcac ctccatatgg cttccgggcg 1282381 gagccatgtc cttatggaaa gttgccgcaa gcatccctgt gtagtgcatg cccgaaatcc 1282441 caatgcccat tacaattgaa ctgacgcctt tatagaatat aagatgctca gaatgttttt 1282501 ttacggccaa gtcaaagaat atttttaacg agacgaaaga ggctgcaatc gcaatgataa 1282561 ttgaaactgt aaataaaata ggttcgtaaa taatcattac ccgggaaatg gcagacattc 1282621 cgatatagtg catagaagca atagatgcgc caagcacaac tgatccggta agcagtctgt 1282681 aatatgtaag aatgtgccgg ctgacaaaat ataatgacac aaatgatccc gaaacagatg 1282741 cgccaatggc tgccattaaa ggcatgaatt catattccat cggcatttcc atatggacgg 1282801 ccatcatccc tacaaaatgc attgaccaaa taccgaatcc cataataagt gagccgccga 1282861 tcagccaaat tttacttttt aagcctgtat tgatggtgac tttccttgaa agttcaaggg 1282921 aaatatacga ggcggtacag gcaattagaa tagataaaca tatgagagtc gtattatatg 1282981 taacgtgtat ttccaaatgg agattccccc cgtatcgtgt gttccagtct tgttgactct 1283041 ctttattatc ggctgcttaa ccgcagagtt tcagccttca aaacgataga aatacgaggg 1283101 agatctattt ttagttcaac tgaccgtgaa aaatgtgtta aaatcatctt gatgttttcc 1283161 gaaaagagaa aaatgtatga tacataaaca tgaaacaagg gagttggtgg ctatcgaaga 1283221 gctggttatg tcatggattg aagcatttaa aagcttatct tattttggaa tatttctagc 1283281 gctcagcatt gagtttattc cggccgaagt cgtcttgccg cttgcgggct attgggtatc 1283341 taaaggcgat atgacacttg ctggcgttgt tttggcagga tcgcttggag gagtggccgg 1283401 tccgcttacg ctgtattgga taggccggta cggaggaagg ccgtttcttg aacgttttgg 1283461 gaagtatctc tttattaaac ctgaagcgct tgataagtca gataattttt tcaaaaaaca 1283521 tgggggcttt gtcgccttca gcggccgttt cttgcctggt atcaggacat tgatttccat 1283581 accgtgcgga attgcaaaaa tgaatgtttg ggtgttttcg ctttatacat tcattgctat 1283641 gcttccgatt acatttgtat atgtttatct cggtgtgaag ctcggtgaaa attggaaggc 1283701 agtcggctct attcttgatc aatatatgct tccgatcggg atagcgattt tggcgctgtt 1283761 cctgctctac ttactgatga aaaagaggaa gaaacgcacg cactccgaac aattatctgt 1283821 atttttgaaa aataaacgtt gacaaatcac tgcgctgcgc atattattga cgtataaaat 1283881 catatttctt gaaatcccaa aggggagtag cgtccggaat gtattccgga aacaaagtcg 1283941 tcatttcatg gattgtatcc atcggctttg ttggcatgcc tgaattcatg tctagcaaga 1284001 cctttgcctt atgtcggcaa aggtcttttt tgcatggtcc ggccggcata agatcggatg 1284061 aagagaaaga aaacaacttt tttgggaggg tatcatttat ggatgcagca ttattattag 1284121 agtatggttg ggttcttctc gtcttgatcg ggctggaagg gattttagcc gccgataacg 1284181 cgctggttat ggcggtaatg gtaaaacatt tgccggagga aaaaagaaaa aaagcgttat 1284241 tttatggatt ggcaggggct tttgttctgc gatttggctc tttatttgca atttctttct 1284301 tggtcaacgt atggcaggtt caagcgattg gcgcgatcta tttgctgtat atctcagcaa 1284361 gccacttatt gaaaagatat gtatttaaga aagaagacac acataaagag acgaagcaaa 1284421 gcggtttttg gccgactgtt ttaaaagttg aactggcaga tatcgcgttt gctgttgatt 1284481 ccatcttagc agcagtagcg ctggcggtta cacttcctgg gacatcactc ccgaagatcg 1284541 gcggacttga cggaggacaa tttctcgtca ttttggccgg cggtatcatc ggactggtga 1284601 tcatgcggtt tgcggcttcc atgtttgtga agttattaaa ggaacgtcca agcctagaaa 1284661 cagcagcctt tgtgattgtc ggctgggtcg gagtgaagct tgctttatat acgcttgccc 1284721 atcgcgacat agcggttgtt tctgagcact ttatccattc tggaacatgg aagctgatat 1284781 tctggggtgt cttagcagca atcgcggttt gcggctggtt tatgtcaggt gggaaaaaac 1284841 agccggaggg tgcacaaaac gaacaaaaaa acagcacccg tgaacgggcg taatctgaaa 1284901 gactctgctt aaaagcagag tctttttgtg tttgaagcgt tttcataagc gaaataaaat 1284961 aacattttta taacatcttt gttacaaaaa acacgcataa aaccccctta attctttaga 1285021 aaggcacgaa atcatgtata gaacgtcaga atggtttgtc ataattgaga cattggaaat 1285081 caatatttct ttttctcctt tgcgaatccc tatcaaatta gctatcatta atgagtagtt 1285141 atagggagga actgaggtga aaccagtgct tagccttttg tttaaattgg gaaaaaagaa 1285201 gcaaacactt gaaaaagctg ttgagagtat acaaaaaggc aataaagatc tgcaaaatga 1285261 attaatacag caatataagc catttatcgc aaagacggtt tcatccgttt gtaaacgata 1285321 tatagatgaa aaagacgatg agttcagtat tggactgatc gcgtttaatg aagctataga 1285381 aaaatattca cctgaaaaag gaaattctct gctcgcattt gctgagctta ttataaaaag 1285441 aaaagtcatt gattacatta gaaaagaagc cagaagcgca caaaatataa atatcgattt 1285501 acaggaagga gacgatcagg agtcatcaca aagcctgatt gaagccgagc tttccattga 1285561 tgaataccgc cgtcagattg aacaggagca gaggcgggag gaaatcctct attttcaaaa 1285621 gcagctcaag gattatggtt tatcgtttaa agaactgctt gaaaattctc caaaacacac 1285681 ggatgcaagg caaaacgcca taaaggtggc aatgacgctt gttgaacatg aagaattggc 1285741 cgctatcctg tatacaaaga agcagcttcc ggtcaaacag cttgaacagc ttgtctctgt 1285801 aagccgaaaa acgattgaga gaaacagaaa atatattatt gcgatgtgta ttatcattac 1285861 gggtgattat atttatttaa aagattatct taaaggggtg ctgcactcat gagaagaggg 1285921 attatagtag agaaaaataa aaaattcgtc acgttgctga cccctgacgg acaattttta 1285981 aaagccaaaa atgatcgaca cagctatgaa atcggagaag aaatcatgct tccgagtgaa 1286041 acacgcatgg gcagaagggc cagctttttt gattttttta aactgcgccc tttcaaaatg 1286101 gggattttta cgatgactgc tattatgctc tttattttta tagttctccc cgttttttct 1286161 aataataagg cctatgcgta tatgacaatc gatatcaatc caagcgtcga aatggcgtta 1286221 aacagcgatt atgaagtgat tgaactgacg cctctaaacg atgagggaca gaaagtcgtg 1286281 aatgatatag atgattggga gaagactgat tttaaaaagg tgattgacga tattataacc 1286341 gactgcagtg aacacgggta tgtaaaaaaa tcgaaagaaa tattgatttc cactgtttat 1286401 gaaaacacag aagacaatac atataaaaag gctgtgaaaa aacagctgaa tgatgtgact 1286461 gaaaaatata aaacgacata ccgcatggaa tctctcgagt cagatatgca aacgagggaa 1286521 aaagcgaaga aagaaggcgt ctcaacaggc agctacatca aatcaaatga aaagaatgac 1286581 aataaagata taaaagatga ctccagcaaa ccatccgggg aagaggatca aaagagtgat 1286641 gaaaatgagg atgaaaacac cgatcaaact gacacccagg acagcaagca aggagataat 1286701 gaacagctga atgatgcgga ttccggagac cagaaagaag agaaagcgga tgaccagatt 1286761 gatgatagtg acaaagataa aaaaataaag gaatcagatg aaaacacaaa taccgaaaaa 1286821 gatggggacc atgagcaaac cccaatacaa gatcctcaag ataaaggaaa tgaaaataac 1286881 ggcgctgaca agggccaaag ccaatatcac agggactgga acaatggtga acaaggcaag 1286941 aaccgttctt cgtccagaag ggataacgct tcagaccgac gtaatccaaa cggctacagc 1287001 agtgataatc attcagctaa aaatgaagat tcgccgagtg cccccggcga ataaagacct 1287061 gaatttattt agttgtgcca tttaattgtg attgtgcttg ctgtaccagc cgctttgtca 1287121 tttctccgcc tacagagccg ttagcgcgtg cgactgtatc agaaccaagg ttcacaccga 1287181 attcttgagc cacttcgagt ttaaattggt ctagtgcctg ctccacccct ggaacaacga 1287241 gtttatttct gctcgccatc tttttcatct cctttttcga taaagaaatt cttaacgcgt 1287301 atttagtttg aaatatacgg ggtttattta tgctggcaat tgttgtggag aaaaataaaa 1287361 ccccggcctc tgagccgggg tggcgcagac tatagaatgt ctgctgtcat tttatgtgcg 1287421 gttgcctgaa tatggaatgt caaaatggag aggactgtaa tggcgataat ctgtctgatt 1287481 ttaagccatt ggctgtcatt cagttcttca aaacggtgac ggagacgctc tgtctcctgt 1287541 tcggcgatct cctgcagatt tgattctttc atagaaggag tatcttggtg atggatggca 1287601 tcaagcacat atgcgcagct ttcataataa gcaatcgggc tgatgacatc atcagatctg 1287661 tctgagattg tgttaaaggc cacttttaaa atagcccgta tgtgttcaaa gtcataaatg 1287721 gattttaaat cacgtacaat taaaagaata actgcctgtt caattgagta ttttttgccc 1287781 agctcagggt gtccgatcag atctttgata tcacgcttta cccagttttg aatcgcggtt 1287841 gactttaacg aagtcagctc gcataagttg ccaagctcta cgatttcatt tgtagacaga 1287901 ccgtattctt ttttctgttt ttttcgttcg tatcttgtaa gaaattcagg aatttctaga 1287961 tgattggctg ctttttctgc tgacatgttc gctgattgga cgagaatgtc gagcgggcta 1288021 tgttctcctt gtccttttag ggaatagagc agccgcacca tatcggttcg agagagttta 1288081 aaaatgttca ttgttcacct ctttaaacaa tttgacgcgg atataggtct atgtataagt 1288141 tcaaaattca agcgtcagca aattacatta acatcatacg tcgaattcct tgcattttca 1288201 aatggatgtt ttataattta aatatacggg ttcttttgaa cttaaaataa cggaggttgt 1288261 tatggcgaaa agaatttttc tgtttattct aacgaatatt ttggtgctta caacaatcgg 1288321 gatcgttttg tctgttttaa gctctgttac aggagtcggg acgtacttta cagctgatgg 1288381 cggtatcgat ccaatggcgc ttcttgtgtt cagtttagtc gttggatttg tcggttcctt 1288441 tacgtctctt gcgatatcca gatggatggc aaagacgatg atgggcgtca gagtgctgaa 1288501 tccgaaaaaa cactcgctca gctatgagga acagcaattg gttgatcgtg ttcacagatt 1288561 aagccgctct gccggtttaa cgaaaatgcc ggaagtcggg atttaccgtt cacctgaagt 1288621 aaacgcgttt gcgactggac cgtcaaaacg ccgttcactt gtcgcagtat cgtcagggct 1288681 gctggagcag atggatgacg cagcagttga aggtgtgctt gcccacgagg tcgcgcatat 1288741 cacaaatggt gatatggtaa caatgacgct tttacaaggt atcgttaata cctttgtcgt 1288801 ctttttatcg cgtatcgccg cttggatagc aagccgtttt gtcaaagaag atctagcgcc 1288861 gatcgttcat tttattgcaa tgattatttt tcagattgtc ttttcgatac ttggcagcct 1288921 ggttgtgttt gcgtattcac gccatcgtga attccatgct gacaggggag gagcggatct 1288981 tgccggcaag gacaagatga ttcatgcgct gcggacgctt aaaagctatt cttcccggat 1289041 tttggaagac gatcagacag ctgtccaaac gttaaagatt aatggcaaga agcgctcttc 1289101 acttttctct actcatcctg atttagatga gcgaatcaga cggctggaag ctaaataata 1289161 caaacacatt gttcctctga gagaattctc agaggttttt tattttatcc attgactaaa 1289221 atcataaaaa aataagcaag ttaagaaaat gtttcgtaaa agcctttaaa aatggaccta 1289281 atatctttag aataattacc gtacttaaaa agagaggcag aaggatttta catgagatta 1289341 aagtttggaa aattgataca ggccttgtca ccggcccagc tgatcgcatt atattatttt 1289401 cttgcagtta ctgtggccgt tatattgctg agtttgccgg cggcccataa accgggggcg 1289461 gattggacgt ttattgatgc gctttttaca gctgtcagtt cagtcagtgt aacggggctg 1289521 acagttgttg atacagctga tacattcagc acaataggga tttttatatt agcatttgtt 1289581 ctgcaatttg gcggaatcgg aattatgacg ctcggaacgt tcatttggct gatcatggga 1289641 aaacgaatcg ggctgaaaga acggaagctg attatggttg atcaaaacca atcccagttt 1289701 tcaggaattg tcaatctgat gaagcaggta ctgtttctga tcttgtggat tgaatttttt 1289761 ggcgggctga tactcggcac atatttctta acctactatg actcctatca ggaagcctat 1289821 ttacacggat tttttgccag tatcagtgca acgacaaacg gcggatttga tattaccggt 1289881 aattcgatga ttccatttcg ccacgattac tttgtgcagt ttattacaat gcttttaatt 1289941 atatttggag cgattggatt tcccgtgctt gttgaagtaa aggatttcct gttttcaaag 1290001 catcggcgtt atccatttac gctttttaca aagatcacga cgattacgtt cggctcactt 1290061 gtcttgtttg gagccattgg catctttgcc ctggaagcaa accatgcgtt cgcaggaaaa 1290121 tcatggcatg atattttgtt tttgtccctg tttcaatcaa cggcaacccg aagcgggggg 1290181 ctggcaacaa tcgatatcag ccaattatca gattccacac tcttttttat ttgtgcgctg 1290241 atgtttattg gagcgtcgcc aagctcagtc gggggaggca taaggacaac gacttttgct 1290301 ttgaaccttc ttgcgctgtt tcattttgcc cgcggcaata aggccgtaaa ggtattcaaa 1290361 cgggagcttc accctgctga cttgatgaag tcgcttgttg tcacgatgat ggcgatcctg 1290421 ctcgtttttg gcgcgacact cattctgacc attacagaaa aacattccct gctggagctt 1290481 ttgtttgaag tgtgctcggc attcggtaca accggcctat cgcttggaat tacggcagat 1290541 ttgagcagtg ttggaaaatg cgtcattatg attgtcatgt ttatcgggcg aatcggcatc 1290601 ttgaccttcc tgtatctgat cggaagaaag gaaattgaag cgaattatca ctatccgaag 1290661 gaaagagtga ttatcggata ggcaaaacac cgcatatttt gcggtgtttt ttgattacca 1290721 aaaaaaagat gtgtgcctcc tgttcagttg gagaacctaa ctccgacagg tgcaatttac 1290781 gctcctgcat cttaaaatgt ctgaaaattg gcgaggagga ttcgtatgaa gcgtaaagct 1290841 gaagtgaatg aagccattaa aaataacaat acacctaccg agagcatgga ccccaattca 1290901 tataagacac aatatcatga cgaccccaat tttagagggg caaaccgcaa ttccaaacag 1290961 ggccagcagg gaggcatgta attgtgaaga aaaaccgtca tagcagagac atgcaaaatc 1291021 ataaaaagcc tatgaataaa aaggtgctgg aggaagaatt ctcaagtgaa ctcggggatt 1291081 acaatgccgg aaagatcatc gaaacgctgg aagtcaccaa gcctgaaaag aaaaaagaaa 1291141 aaaacaaaaa acaacaataa aaaagacctc ttaggcggcg tcccgcttaa gaggtgcttt 1291201 ttctatttta aataagcatt tttgcccgtt cctctgacaa attgcaataa gcttgtcatc 1291261 ctcagctcaa tgaatggctg agcgactgtc ttaacaaagt tgctggagag gactgatgtc 1291321 agggctgctg ttaaaagcaa gaggatcact aagctttgat agtcagtaag ccaatcctca 1291381 agcccgacct gccgtaatgt cttaataata aacccgtgaa gcagatacac gtaaaatgtc 1291441 cgggttcccc atttggtaaa gaaataccgt ttttgcggaa cgagcgctaa aaagctgaag 1291501 gttgccccaa aggcgagtac ataccagccg attcgggata gtccgcttac cagggtaacg 1291561 tctccaaatg aagaatacgg ttttgaacca aacagaaaag aatagtcaaa atcgatgccc 1291621 cagcagatga cgaatactgc ggcaagcact ccgagcgcaa tttgtttgcc gcgttttgat 1291681 ctcaataaat caaaatgatg tttatttaaa taaaaaccga caaggaacat cggtaagaat 1291741 acgaatgtcc gtgacaagct cagcgtgctg ctgacaaagt ccagataacc gatcagcacg 1291801 gcgattccgc agctgacaaa cagcgcccac tgctttgaaa gctttgaaaa aggatatagg 1291861 agcaggttcc aaaagaataa gcttacaaga aaccataacg accattgcgg atcaatcggg 1291921 ttcacatttg ccatgctttc atcttgcata atgtaataaa agacggaata aataatttgg 1291981 aaaatcaaat acggaataat cagcttgacc gccagctttt ttacatatcc cgcccgttta 1292041 aagcctttcg cgaaataacc ggatacaaga ataaatgcag gcatatggaa tgtgtaaatg 1292101 aacttgtaga ggtagagcat aaaatgatta tcattaataa aggaacgaag gatatgaccg 1292161 aatacaacaa ggaatatcaa taaaaatttt gcgttatcga aataactgtc ccgcgattta 1292221 ctcatagcat caccttctct ttcatcagtc actaagagat tattccctgc tggtacatat 1292281 tttaaaataa aagatgaaaa aggaatctaa aaaaatgctg attgttaggt cgatgtaaag 1292341 tgacggtaag gatcgtagaa aatgtcttcg taatgtaatg acgctgaaat tttctgaaat 1292401 ttatagggca aatgaaggaa gttcccgcat tttgtagaaa tattgaggga taggttttga 1292461 agaaggagtg tacatgcatg gaaactcttg gtgtccagac aaactcggag ctgcgagagg 1292521 aactgaatcg cctcaaagaa gaaaacgcgc gactgaaaaa ggaattgaat cagcatcaag 1292581 tgattgtcaa caatacgctc gatgctattt ttatttgtga taacgaaatg cggattgttc 1292641 aggcaaatga agcaacagaa aggatgcttc aagttgactc ggaagatttg aaaaagcgtt 1292701 ctgttttgga ttttttgttt tcaatcccaa aggatgaact gaatctttcc gtaaagaagt 1292761 tttttaaaaa aggctttctg tggaaggagg ttccgatcag gcttgattgc ggggcaacaa 1292821 aatacataga gtttctggcc aaaagaggta ttggtgagga tttctttttt gttgtcatga 1292881 gggacatatc ttctaagaag attctggagc gggaattctc tatgaatgaa cagcttttta 1292941 aggacttgtt tgacagagca gttgacggaa tcgtcctgtt tgataaagat ggcggtttta 1293001 ttgatgcaaa tttgtccttt tgtaaaagct ttgaaatcaa tcataatgag ctgtctcatt 1293061 tatctttgta tgagttcata gacagcggct cacgaaaaga tttcgacaat atctggaagg 1293121 cgctcaaccg caagggaaaa gcgaaggggg agctgcctgt caagcttcgt tcaggagttc 1293181 aaaaactatt tgaattcacg attacatcaa acatcatcag cggtttttat atgtccatta 1293241 tgagggatat cacagagaag cggtctatgg agctgcagct ctttaaaagt gaggagcgct 1293301 tcagagaaat ctttgaaaat gcaatggacg ccatcatcat ctggtcgaat gacggaagaa 1293361 tcgtaaaagc gaatcaatca gcctgtaaaa tttttgagct gccgatgaat ttgctgttga 1293421 aaagaaagct gtgtgatttt ctcgttgact cgcagcagaa atacagcata acgaagagga 1293481 aatacgcaaa atacggagag atcagagaag agctgctgtt tcaaatgggg aacggccaat 1293541 tcaaagagct tgaatttact tcaaaacgga caatccttga aaatcagcat ttgacgatct 1293601 taagaaatgt aagcgacaga aagcggatgg aaaaggagct tcgggaaagc gagctgaaat 1293661 tcagaaaagt gttcaacgga tcaatggacg gcaatgtatt gttcgacaat caatacagga 1293721 tcatcgacgc caacccgtta gcaagccata ttttgggcct gtcacatgaa gagatcaaac 1293781 agcacagcct gttagatatt atttctgctt atgaaataga aaatttggca tcaccggcaa 1293841 ggcagattaa ttttgatgaa atggacaacg aaattccatt tttgctgagc agcggtgata 1293901 acagaaaact cgaattctca tttaaacgga atattattca aaatatgaac ttggctatct 1293961 ttaaagacgt aacagagcga aaagaattgg aggagcgcct gcgcaaatca gatacccttc 1294021 atgttgtcgg cgaactcgca gccggtattg ctcatgaaat cagaaatccg atgactgctc 1294081 ttaaaggctt cattcagctt ctgaaaggga gtgtcgaggg agactacgcc ctttacttca 1294141 acgtgatcac ctcagaacta aagcgcatcg aatccatcat caccgaattc ttgattttag 1294201 ccaagcccca ggccattatg tatgaggaaa aacatgttac ccaaattatg agggacacga 1294261 tagaccttct aaatgcgcaa gccaatctca gcaatgtaca aatgcaactt gatttaattg 1294321 acgacattcc cccgatttac tgtgaaccga atcagctgaa acaggttttt atcaatatat 1294381 taaaaaacgc catcgaagtg atgcctgacg gcggaaatat ttttgtaacg ataaaggcat 1294441 tggatcaaga tcatgttcta atctccttaa aagacgaggg aatcggaatg acagaagata 1294501 aattaaagcg acttggtgaa ccgttttata cgacaaagga acggggaact ggacttgggc 1294561 ttatggtaag ctataaaatt attgaagaac atcaaggcga gattatggta gaaagtgaag 1294621 aagggaaggg caccgttttc catattacgc ttcctgtcag acagaatgct gaagaaagaa 1294681 ggaatgatga atgaactact atacgacagc cgaaacgccg ctcggtgaac ttatcattgc 1294741 cgaagaggag gaccggatca ctcgtctatt tctcagtcag gaagattggg tggattggaa 1294801 agaaacggtt cagaatactg agcataagga aacacctaat cttgcagaag cgaaacaaca 1294861 gcttcaagaa tatttcgcag gcgaaaggaa gacattctcc ctgccgctca gccaaaaggg 1294921 cactcctttt cagcaaaaag tgtggcaagc gctggagagg attccatatg gcgaatcccg 1294981 aagctatgcg gatattgccg ctgctgtcgg cagtccgaaa gcggtgcgcg ctgtcgggca 1295041 ggctaataaa cgtaacgacc tgccgatttt tgtcccgtgc cacagagtga tcggcaaaaa 1295101 cagtgcgtta acaggatacg ccggaagcaa aacggagatc aaagcatttt tgctaaacat 1295161 cgagcgaatc tcctataaag aaaaataaaa catatggcac gttccctttt ttcacggccg 1295221 acatatcatt ttattaagtt aaaaaagttg gtctgatgaa aaaggaggac aaagcaattg 1295281 aagccgagcc gctctgagaa acttgccgtt tttgccgaac tgtttgtgaa actgcatatc 1295341 ttatcaagcg ctcaaaaaga tgaaatcatc aatgttaaca aaaagaaaca aaaaaaccgc 1295401 tgactcggct ccaaatgagc aaagtccagc ggttttttaa tgcacctttt ctcctttaaa 1295461 cagctgttca atctcttctt catagtttcc ggtcataatc cctttttctg tgatgattcc 1295521 tgaaatgaga tcatgaggtg taatgtcgaa agcgggatta aagacaggca cattggatgg 1295581 agcggtccga actccggaaa tctgcctgac ttcctcggga tctcgttcct ctatcgggat 1295641 atcagcgccg catttgacct ttgtatcaaa tgtagataaa ggtgcggcga caaaaaacgg 1295701 aatatcaaag gcgtttgcta aaatagcaag accgtatgtg ccgattttat ttgccgtatc 1295761 accgttcttt gcaattcggt cggctccgac gataacagcg gaaatttgtt tttccttcat 1295821 cgtatgggcg gccatgctgt ctgtgatcag agtgacatca atgcccccct gcatcagctc 1295881 ccaagcagta aggcgtgaac cttgcaggac aggccttgtt tcacaggcat aaatgtgtaa 1295941 tcccaaatct ttttgtttgg ccaagtaaaa cggagctagc gccgttccat agcggcttgt 1296001 cgcgattgag ccggcattgc agatcgtcat gatcctgtcg ccttttttga aaagctgcag 1296061 ggcgttttgg ccgatcaacc ggcacgtttc ctcatcctcg acctgaatct gaatggcttc 1296121 atggacaagg tttgtttttg cttcatttac ggaaatcgcg ttttcgaccg aatgactcag 1296181 tctctcaagc gcccatgaca aattaatggc ggtaggccgt gagctgttta aatattgttt 1296241 gatgtcttcc agtctgcggc ggaattccgt gacattgtct gtttcaatgt ctttggcagc 1296301 aagcgccagt ccgaaggcag ctgtaatgcc gatcgccgga gcgcccctta ctttgagcgt 1296361 gacaatcgca tcaaatacat cctctttcgt cgtcagctcc aaatattccg tctcatcagg 1296421 aagcttttgc tgatttaaaa tggtaatagc tgtttctttc cattcaacag aacgtggaac 1296481 agcaaatgaa tgggtcatga atagatcatt cctttacaag taacttaaat aattcaataa 1296541 catctgttat cgttttgaat tccgaacgtt tttcgataaa ggctgtgccg gtttcgagcg 1296601 ccaagcgttt tctgccgatt cgtttatcaa acggcacgat cgtatccagg tcagctacat 1296661 gggcaaggcc gatcgtgcgt cgtatcagct cacagcccgc aaatccgatt gcttcttcaa 1296721 aaatatggct gagcgtatca gtgaggtaac cgtcgatgtt ggcgtaaaca tccagactgt 1296781 ccttctgcca ggcttcacta aacgtctctt caaacgtttc ccagacctgg ttgacatgtt 1296841 catataacgg ctctctgtca gccccgtcac ggctgagtgc gttcaaaaat aagttggcga 1296901 taaattgccc tacatcaaag ccgatcggtc cgtaaaaagc aaactcagga tcaatcacct 1296961 ttgtttcgtg ctcacttgcg aaaatgcttc ctgtatgcaa atcaccatga atcaacgttt 1297021 ctgcagacgt taaaaatgac tttttcagct tagcggcttc gattttaacg ctgtcattat 1297081 tccaaagctt ttcgacaaaa ggacgaagct cttcttcaaa atcatttgtg tcatggtcga 1297141 agaaaggatc tgtaaaaaca agtctttccg taatgtcgca tagctctgga tttgtaaact 1297201 gtttaacaag ctgttttttc accttaggtt caagcgcgta atctgatgag tagaaaagtg 1297261 tttttcctaa aaattcaccg atgtgctgcg acagatgagg atagttttca ccctcaatga 1297321 gtccttttct tgcgatcttg aggtgagaga gatcctccat gacggtaacc gccatttccg 1297381 tatcagaata aaacactctt ggaaccaggt gaggcacatg ctcgccctga cggatgagag 1297441 cgctgctttc gattcttgca cggtcgattg tcagcggcca gctttctccc accacttttg 1297501 catacggaac cgcctgttta atgatcaatg ctctgtcatg ttcttgatca taaatatgaa 1297561 aaacgtaatt taagttgccg tctccgatct cctggcatgt cagcgtgctt ttgcttggaa 1297621 ataggccaag cttcaccgcc aacgccacag cggagctttc atttaacgtt tcgtataaag 1297681 gtgtttttgt gactcccatc atcataacct ccaattatgt aattaattaa tatgtggccg 1297741 taaaaaagcc tccttctcag agagaaggag gcttaacatc tatgtccgcc tctcttatct 1297801 ctcagatcag atctgaatgg aattagcacc gtgccttaag agaccagcgt ctcggcgcga 1297861 aaaaaatgcg ccccatttca caatggaatt acggtcggtt gcttttgggg tcaaaaggcc 1297921 aaatccctcg cccaactctc gataagagaa tatattcact tgtttgacaa ttctaattta 1297981 tcagttgatg aacatggtaa caggtaattt agttagttgt caatatattt tttaatataa 1298041 atcttttctg atatcatcga aaacaggaat gctctcccga acttctgcgc tttcttgaag 1298101 gtcgatttcc gctcggacta tgccttcttc ccggccgcct tcagcaagta cacgtcccca 1298161 tggatcaata atcaggctat gtcctgcaaa ttcattatcc ggatttgaac cggtacaatt 1298221 gcaggctgcg acaaagcatt ggttttcaat ggcccgcgca ataagcaggc ttttccaatg 1298281 atcaaggcgg ggaagaggcc attccgcaga aataaacagc acgttggcgc cttttgtcgt 1298341 atgttttctg atccattccg gaaaacggat atcgtaacag atcaatccag agcttttgac 1298401 gccgtcaagc tcaaagtatc cgtcttcgga accggctgat aaatacagat gctcatccat 1298461 cagctgaaaa agatgggctt ttctgtactc tttaatgatt tgcccttcct tatccgcgat 1298521 gtacattgta ttataaacat cagaattctt cctgacagcg accgatccgg cgacaatatg 1298581 aacaccatgt ttttttgccg ttttcttcag ccagctctga gcggagcggc cgtcttcgtc 1298641 agcgagttca tcaagattgg ccagatcata tccggtcgtc cataattcag gcagaacaag 1298701 aacatcagca tgtttgcttt ctttttcgat gaaaaattca gcctttttta tattttccga 1298761 aggttttccg tatgaaatat caaattgaag acaagatatc gtccatttca tctttttaac 1298821 accccaaatt tttctttact tttttcattt aaccatatat gatgatggac tatcatttca 1298881 agattttttt agaaggtgag aatagatgaa atttgaacag tctcatgtat tgaaggaatt 1298941 gcctaaacaa ttcttcgctt ctctggtgca gaaagtgaac cgaaagcttg cagaaggaca 1299001 tgacgttatc aatctgggac agggaaatcc agatcagccg actcctgagc atattgttga 1299061 ggagatgaaa cgagctgtcg ctgatcctga gaatcataaa tattcgtctt ttcgcggctc 1299121 ataccgtctg aagtcagcgg ctgctgcatt ttacaaaaga gaatacggca ttgatctgga 1299181 tccggaaacc gaagtcgctg tattattcgg cggaaaagcc ggtctagtcg agctcccgca 1299241 atgcttgttg aatcccggtg atacgatttt agttcccgat ccgggttatc ctgattactg 1299301 gtcgggtgtc acacttgcaa aagcaaagat ggaaatgatg ccgctcgtaa aggacagagc 1299361 gtttctccct gattacagca gcataaccgc tgaaataagg gaacaggcga aattgatgta 1299421 tttgaattat ccgaataatc cgactggagc tgttgctact tccgagttct ttgaagatac 1299481 cgtgcgtttt gcggctgaaa acggaatctg cgtcgttcac gattttgctt acggcgctgt 1299541 aggatttgac ggctgcaagc ctttaagctt tttgcagact gaaggtgcga aggatatcgg 1299601 aattgaaatt tacacgctgt caaaaacgta taatatggca ggatggcggg ttggctttgc 1299661 cgtcggaaac gcttcggtca ttgaagcgat caatctttat caagaccata tgtttgtcag 1299721 tcttttcaga gcgactcagg aggctgcagc agaggcactg ttagccgatc agacgtgtgt 1299781 ggcagagcaa aatgccaggt atgagagcag gagaaacgct tggatcacgg catgccggga 1299841 aatcggctgg gatgtaacag ctcccgcagg ttcttttttt gcatggctgc ctgtgcctga 1299901 aggctatact tctgagcagt tctcagatct tttgctggaa aaagcgaatg tggcagttgc 1299961 ggctggaaac ggcttcggtg aatatggcga gggctacgtc agagtcggac ttttaacaag 1300021 tgaagaaaga cttaaggaag ccgcttatcg aattggcaaa ctgaacctgt ttacccaaaa 1300081 aagcattgac aagaccttat aacgatggga taattcaaaa taatttataa aatctatatt 1300141 ttcttatcaa gagcaggcag agggacgagc ccgatgaagc ccggcaaccg acttataaag 1300201 cacggtgcta attcttgcag ctagcggctg agagataaga ttcggacgag aaacgaaacc 1300261 tctttagacg cgattgcagt ttgaagaggt tttttgatat ggatgaaaat gaaaggagct 1300321 ctggcatgag tgagttatta gcgacatatc tcctgaccga accgggagcc gatacagaga 1300381 agaaagcaga acaaatcgca acaggattga cagtaggctc ctggactgat ctgccccttg 1300441 taaaacagga gcaaatgcaa aagcacaagg ggcgggtgat aaaagttgag gagagagagg 1300501 gaactgctgc atcagaaaaa caagcggtca tcacaattgc ctatcctgaa atcaatttct 1300561 ctcaggatat tccggctttg ctgacaacag tgtttggcaa gctgtccctg gacggaaaaa 1300621 tcaaattaat cgatcttcac ttctctgaag catttaagcg tgcactgccg ggaccgaagt 1300681 ttggcgtata cggcatccgg aagctgctgg gagagtttga gagaccgctg ttaatgagca 1300741 tatttaaagg cgtaatcgga agggacctga gtgatattaa agaacagctc cggcagcagg 1300801 cgcttggcgg agttgacttg attaaagacg atgaaatttt ctttgagact ggtctagcgc 1300861 cttttgaaac aagaattgca gaaggaaagc aaatattgaa agaaacgtat gaacaaaccg 1300921 gacataaaac gctgtatgcg gtgaatttga ccggacgtac ggctgatctg aaagacaaag 1300981 cgagacgcgc cgccgaattg ggagcggatg cgcttttgtt taatgtcttc gcttacggct 1301041 tggacgttat gcaaggcctt gcagaagatc ctgaaatccc agttccgatt atggcgcatc 1301101 cagcagtgag cggagcgttt acgtcttctc cgttttacgg tttttctcac gctcttttac 1301161 tcggaaaatt aaaccgatat tgcggtgctg acttcagcct ctttccgtct ccatatggtt 1301221 cggttgcgct tccaagagca gatgcactgg cgattcatga agaatgtgtg agagaggatg 1301281 cttttaacca aacatttgct gttccgtcag caggcattca tcccggcatg gttccgctat 1301341 taatgcgtga tttcggcata gaccacatta ttaacgccgg aggaggcgta catggacatc 1301401 cgaacggtgc ccaaggcggg gggcgagcgt tcagagctat tattgatgcg gtcctagagg 1301461 cccagccgat tgatgaaaaa gccgaacaat gcaaggatct taagcttgcg ctagataaat 1301521 ggggaaaggc tgaagccgta tgacgactcg aaaacctttt attatttgtg attttgacgg 1301581 aacaatcacg atgaacgaca acattataaa tatcatgaaa acatttgctc ccccagagtg 1301641 gatggcatta aaagacggcg tactttccaa aacgctgtca atcaaggaag gtgtcgggcg 1301701 gatgttcggc cttctgccca gcagtttaaa agaagagatt acaagttttg tattggaaga 1301761 tgcaaaaatc agggaaggct ttcgggaatt tgtagcattt atcaatgagc acgagattcc 1301821 gttttatgtc ataagcggtg gaatggactt ttttgtatat cctttgcttg aaggcattgt 1301881 ggagaaagac cgcatttatt gcaaccatgc ttcatttgac aatgactata tccatattga 1301941 ctggcctcat tcctgcaagg gcacatgcag caatcaatgc gggtgctgta agccgtcggt 1302001 catccatgaa ctttctgaac cgaaccaata tatcatcatg atcggtgatt cggttacaga 1302061 tgtggaggca gcaaagctgt ctgacctatg ctttgcaagg gattatttat taaacgaatg 1302121 ccgggagcaa aacctcaatc atcttccgta tcaagatttt tatgagatca gaaaggaaat 1302181 tgagaatgta aaggaggtac aggaatggct gcaaaacaag aacgctggcg agagctcgct 1302241 gaagtaaaac gggaattggc agagagagat tggtttccgg cgactagcgg caatctgtca 1302301 attaaggtta cagatgagcc tttaacattt ctcgtcactg caagcggaaa agataaacgc 1302361 aaagagacgg ttgaagattt tctgctggtc gatcaaaacg gagagcctgc tgaaagcggg 1302421 cattctctga aaccgtcagc agaaacgctt ttgcatacac atttgtacaa taaaaccaat 1302481 gccggatgct gcctgcatgt ccatacggta aacaataatg tgatttcaga gttatacgga 1302541 gaccaaaaga aaatcacatt caaaggccag gaaattataa aagcactcgg cttgtgggaa 1302601 gagaacgcag aagtgaccgt tccgattata gaaaatccgg cacatatccc gacgctagcg 1302661 gcactgtttg cggaagagat ttcagaagat tcaggagctg ttctgatccg aaatcatggt 1302721 attacggctt gggggaaaac agcatttgag gcaaaaagag tgcttgaagc gtatgaattt 1302781 ttgttcagct accatttgaa attgaaaaca ctcgagcatc agctggttaa ataaaaggag 1302841 gaattgaaat ggctacaatt cgaattcatg atgaggcaaa tacaacgatt gaaaatcaag 1302901 aggaagtggc aagctttctg gacagtcaag aggttattta tgagcaatgg gatatcacga 1302961 ggcttccgga acatctctca gagaaatatg acctgacaga agaagaaaaa cagcaaattc 1303021 ttgatacctt cgaaactgaa attaaagata tctcaacccg ccgcggctat aaagcacagg 1303081 atgttatttc attgtcagac agcaatccga aacttgatga actgcttgaa aactttaaaa 1303141 gagagcatca ccatacagac gatgaggttc gttttattgt aagcggacac ggtatttttg 1303201 tcattcaagg ccaggacggc acgttttttg atgtccgttt aaaccctgga gatttaatct 1303261 ccgtgcctga gaatatccgc cattacttca cgcttcagga ggaccgcaaa gttgtcgcgg 1303321 tgagaatttt tgtcacaact gaaggctggg ttcctattta tgaaaaagac agcgtgaatc 1303381 aataagcgtg agatagcccc gttcatcgaa cggggctttt tatatttatt gcaaacgcca 1303441 cttttcatat tgtgacagtt cttttttaat cagtgtccaa atcaaaccta aaacagctgc 1303501 atcgtcaatg aatccaagac cgaggattac gtctggaatg atatcgagcg gcatgacgat 1303561 atacaggatt gcggcagtta acagcaaaag tgttttaacc tgtgaacgag ggtagtcgcc 1303621 atttcgccaa tcgcgaagca tctgaaaaaa agtagtgatg tgctggatac atttttttcg 1303681 gtttttcctc tttaaaatcg cttttccgcc tgccgctccg agcattattg ctttcttttt 1303741 cttcattggg catacctcct gcctggcggc gtgtttaaga tattcttcac ctgggtattg 1303801 ttcttctaat cctatcaata tatctattat acctgaaaaa ttaacttatt taatgaaaat 1303861 atgtttacaa ataaagtata atctgtaata atgcacaata acccaatcaa acttgtttcc 1303921 tatttcttag cggcgagggg tgaagtgaat gggcggttct tctgaacaag aaagattgtt 1303981 ggtgtctatt gatgaaaaaa gaaagttaat gatagatgcc gctagaaagc agggatttac 1304041 agggcatgac acgatcaggc acagtcagga gctggattgt ttaataaatg aatatcatca 1304101 gcttatgcaa gaaaacgaac attcccaagg gattcaaggc cttgtaaaga aattaggctt 1304161 gtggccccgc agagatgtta tgccagcata tgatgcaaat aaatagcggc ctatcagatg 1304221 catatataaa gagagagctt ttcggaagcg ctcttttttt ctggaaaaaa ttcatatgaa 1304281 agagggaact aatgaaggaa ctggcgattc tcattaccga aatggtcaat caatttcatg 1304341 atgcttttat ttccttatgc ggaatatttg gcattcattt aactgacaaa gaaatgcatt 1304401 tttgggtgat cggcattttt ggcatattct ttttcggcgt cactcacgct gtgtttacat 1304461 ggctttctaa atggagtatg acagccttgt cctttatcta taccgttaca gtcatcattg 1304521 tcatcgtatt tgcgattgag attcagcaaa aggtgacggg gagagggaat atggagtttt 1304581 tagatgccac ggaaggtata aagggttttt tagtattttt tatgtttttt ttgcttttga 1304641 aaatgctgtt gcgtttcatc aaaatccttt tttctggaag accagcaagc aaatcgaatg 1304701 gcaatgcccg atcacgaaga taaaaaaccc tcctgacatg gtcagggggg ctatgatgcg 1304761 gatacgggga gggtgatcgt cacctctgtg cctcttcgca cttcactttc aatatgaata 1304821 gagcctccgt acatcagcac gatccgttta caaacaacaa ggccgagacc ggttcctttt 1304881 tctttagaag taacaaaggg aaggaagatg tgatccagca tttcctgaga aatcccttca 1304941 ccgttatcca caactttgat tatggctttt ttatctaaag ctcctaggga gatcgtcagt 1305001 ttgcctcctt caggcattga ctcgaggcca ttttttgcta catttaaaat cacttgttta 1305061 atatgatctt ttgtacattt tacgagtaag ggctgctcgg ttagatactg taattcgact 1305121 tcaacattgt atagattgcc ctcagaataa atgatcggca taatttctcc gataatgtcc 1305181 tgaagtgagt tcagctccca tttttcagct gtcggcttgc cgagaacgag aaactcactc 1305241 actatttgat tgatgcgctt tatctcctgt tcgataatgg agaagtaaag ctgatcttcc 1305301 tcacctttat atttcttttg caacagctga ataaagccgc ttatcccggt gagggggtta 1305361 cggatttcat gggctgtgct ggcagcaagc gtcccgatca gctctaattt ttgcgcctcg 1305421 ttttctgagc gctccagctg ggtctgccgc ttcagcaaat aatacagcac gagaataaaa 1305481 aggatattca gcagaacaat aatacatgaa agcggaagca caaggctttt cgacagttct 1305541 tctattgtga ccgggttcgg atagactttc atattccagc tgatatcatc cagatatccg 1305601 ctgacaggtt tctgatcctc tgcatgagag gcttgtccgc tcgcaaaaat cattttcccg 1305661 tcttggttca caacttcaat ataaacatca gggcttagta agttaatgag atttttcaaa 1305721 taatcaattt gaatagctgc gacaagataa tctgtcacat tacgttttga gtccaaaaca 1305781 ggcacacaaa ttgtgaaaat tggctgacca gtaattctgc tcgaataact atctgaaatg 1305841 actgtctttt tagtttcctt tgcttttata aaaaaagatc tgtcggccag gtttactttc 1305901 gtttttaatt cggttgtgct tgcggtgacg tctcctttgg cattgagaaa atagagaccg 1305961 gaaaatctcg gctctgaatc aaaggtcttt tccaaaattg attgcatttt ctttatatca 1306021 accggtctgt cgatggcgat ggacaaggag gtcattctcg ccattgtttc tccgattaaa 1306081 taattgattt tgttgcggtg aaggtttagc aggacacttg cttcttgttt atgttctgca 1306141 gctattgtat ctttttcttt ttcatatacg aaaaagctga tgacgattgc cggaatcacg 1306201 accagtatga tataaagttt gactctcccg caggcgcctt ttagtatttt caatttgcat 1306261 cgctccaaca tacacctgat tagaggtatt atatcattgt ttcttcttct ttaataagaa 1306321 aaaataacca aaaaaattag aaaaagatgt tggcaagctt acattttaaa aaagaagaga 1306381 aatattggaa agatttttat tgacattttg gtctttgttt attaatgttt ctctgtaacg 1306441 gtttctaaaa ggatgattga gacatgacag aaaaatcact gaagttattt atcgtgctgt 1306501 cgcgcgcgta tcggtctatt aacgatcata tgaataagca tattcataag catgggctga 1306561 atccgactga atttgctgtg ctagagcttt tgtaccataa aggcgatcag ccgctgcagc 1306621 agataggaga taaaattctc ttggctagcg ggagcatcac atacgttgta gataagctgg 1306681 agcaaaaaga acttctcatt cggaaagcgt ctcctacaga cagacgagtg acatttgcgc 1306741 aaattactga aaaaggcatc ggtcttttga acgatatttt ccctgatcac gctgctgaaa 1306801 ttgatgaaat gatcagcgta ttaagcgaag aagaggtaga gatgtgcacc gaaatgttaa 1306861 aaagagtagg attaaacgca aaacagtttc ataataagta aaaaaaggaa gcctgatatg 1306921 tcacaaggct tccttttttg ctatttttca tttgtttccg ctgcgcctct cggcaaaatg 1306981 agaacttcaa cccgccggtt tttgcttcgg ccttccgcag ttttattgga agccaccggt 1307041 ttatactcgc cataaccctt ggcgctgaac acttttgcat cgagcttggg gttttcaatc 1307101 aggagcccca taaagtttac cgctctcatg acgcttaaat gccagtttga ttggaattca 1307161 gaatttttaa ttggcatatt atcagtatgt ccgctgataa tgatatttct tggcgggtta 1307221 atcacaagaa gatttgaaat ctcttttgca agcggcacat cttccttacg gatggtcgct 1307281 tttccagaat cgaagaagat gctgtcttta atcgtaatca gaaggccttc actagtcatc 1307341 ttcgtctcca gctgatgttc cagcttttta tctttgatga acttttccac ctggctcttc 1307401 acattttcaa gttcttcttg atcagctgct ttttcttttt ctttcttgtt tttctctttc 1307461 tcttcttttt cctttttcac ttcatcgatg ccgtctgact cgttttcagg aggagtgaca 1307521 ctggagtagt ccagtacacc ggttccgcct gtaaaaactt cattaaatga ttttgagagc 1307581 atttgaaact tagctgcgtc aatcgagctg ctcgcgtaca gcacaataaa caatgccagg 1307641 agaagagtaa ggatgtcggc gtaaggaacg agccatgatt catcaacgtg ctcgtcctca 1307701 tgcttcttct tcttttttct cgccattttg cgcctctcct tgttctgcaa atttcaagcg 1307761 gtccttcgca ggaagataca ttaaaagctt ttgttcgatg actttcggtg cttgtccttc 1307821 taaaacggat aaaacacctt caatcatgac ctcacgcagt tttacttcct gttttgattt 1307881 tcgttttaat ttatttgcga aaggatgcca taacacatac cctgtaaaga taccgagaag 1307941 tgtggcaaca aaggcagcac tgatggcgtg tccaagctca tctgtgttat ccatatgaga 1308001 gagagcggca atcagcccga ttacagcgcc gagtactcca agtgtcggag cgtacgttcc 1308061 tgcttgtgta aaaatagcgg ctcctgcttg gtgcctgtcc tccattgctt cgacttcctc 1308121 tgtcataata tctcttataa attccgcgct ttgcccgtca acagccatgc tgagcccgtt 1308181 tttcaagaaa gcatcatcta catcctcaat gcttgcttct aaagcaagca gaccttcgcg 1308241 gcgtgcaagc tgagcccatt cagagaacat aggaatgagt tcctctattg tgagctgttt 1308301 attttcctta aataacactc gaaacagcgt aggcactttt ttaatttctt ttgttgggaa 1308361 cgcaataacg actgctgaga ttgtcccggc gataataatt aaaatggcag cggggtttgc 1308421 aagggcgctg aaactgacgc ctttcagaac catcccgacg ctcaatgcca caaaagcaag 1308481 aataataccg attaacgaag ttttatccat agttttcacc aaatcctttt ttactagctt 1308541 gtctatggtt aatatcggtt ttggtgcccg gaactttagg gacattgtga atttgttcat 1308601 gaaatattca aggaagaggc atagaaggga gaaataaaca aaaacgggct ctccaaaatt 1308661 gaaaagcccg ggggtctact gaaattagca gcttgcttgc aagctgtcct tcagatggta 1308721 ttcatataat agtagaaata catattcact gtatataaac atgttccatc cctccttaaa 1308781 aaagtgtaaa ggatgaaggg aagtagcgct tcaggagaag ggacggtaat ttctaagtca 1308841 agagtatgaa agtataaaaa aaagcggctt cctaaaagga aaccgctgat tgttattttg 1308901 ctcgcacttt gattttatca tcttctaaaa tcacgtgaaa acttgtgatc tcgccattat 1308961 caagcagcag atcggtcatt tcatcctcaa cccattcttg gatggttctt ctaagcggac 1309021 gtgcaccgaa tgaagggtgg tagcccagct cagcgatttt ttctttcgct tcatctgtca 1309081 cattcaagct aatgccccgt tccgccaatg tttcttcaag ttctccaaga agaaggctga 1309141 cgattttgac aagatgttct ttttccaatg agcggaactc aataatgctg tcaaaacggt 1309201 tgaggaactc aggtttaaag aacatgctca gtgaatcaat taatgtttgt tcttcgatga 1309261 cactgtcatc tgattggaaa ccgactttcg tttgtttctc accagcaccc gcattacttg 1309321 tcatgatgat cacagtgtct ttgaagctta cagttctgcc ttggctgtct gtcagacggc 1309381 catcttccat aatttgcagg aacatatgct gaacgtctgg gtgtgctttt tcaatctcat 1309441 ccagcaacac aatgctgtaa ggattgcggc gcaccttctc agttaattgt ccagcttcct 1309501 catggccgac atatccaggc ggtgaaccga taattttaga tacggcgtgt ttctccatgt 1309561 attcgctcat atcgagtcgg ataatagcgt cttttgtgcc gaataattca tctgccagtg 1309621 ttttagaaag ctctgttttc cctacgccgg taggaccgac gaagaggaag gagccgactg 1309681 gtctgttttt ggattttaat ccggcgcggc ttcgtcttac cgcttttgcc actttttgaa 1309741 cagcggcttc ttgtccgatc acgcgttcat gaagttttgc ttcgagttct ttcattttcg 1309801 tttgttcgtc tgcctgcagt ttgccgacag ggatgcctgt tttttgttca acaatttcct 1309861 gaatgtgctc agcttccaca gtgacagcgg tatgagcgga ggagctgttc agttttttct 1309921 ccaatgcgag ttcttcatca cggagttttg ccgccagttc gtaattttct tcttccaggg 1309981 cttttgtttt ttcggcttca attgcagtta agcgttcagc ggcatcctca tcattcagtt 1310041 catcaattaa caggttggct tttgaacctg cttcatctaa taaatcaatt gctttatccg 1310101 gcaggtgtct gtcctgaatg tagcgggatg ataaagtgac acatgctttg attgcttcat 1310161 cactgaatgt tacgccatgg tacgcctcgt atttgtcttt aatcccttgc agaatgagga 1310221 tagcctgttc aattgaaggc tcctgcacca tgacaggctg aaaacgtctt tccagcgcgg 1310281 catctttttc gatttgacga tattctttca gtgttgtcgc gccaatgact tgcagttcgc 1310341 ctctggctag ggccggtttg agaatgttgc cggcgtccat tgatccttct gcagagcctg 1310401 cgccgacgag aaggtgaatt tcatcaatga acagaatgac attttttcgt tccttcagct 1310461 cagtgatcag ctgtttcatt ctctcctcaa attggcctct gatccctgtg tttgcaacaa 1310521 gagatgcaac atcaagcaag tatagctctt tgttttttag tttgtttgga acatcacctt 1310581 cagcaatttt taaagcgagc ccttcagcga tggcagtttt ccctacaccc ggctcaccaa 1310641 taagaaccgg attgtttttg tttcggcggt ttagaatttc gatcactcgc gccacttcat 1310701 catcacggcc gatgacggga tcaatgagac cggcttttgc accgtttgta atattttgag 1310761 ccagctcatc aagcaaccct tttttttcgc tttgttttgc tgcgctctgt tctttcggct 1310821 ggaatgcctg ttcaaacgga aatccgaaag attgaggacc catactcatt gaaggtttac 1310881 gggtcagttc gttatagcaa gtttcacaaa gaaccatctg tttatgaacg gaatttattt 1310941 gcatgttaag gcgaatcgtc gcctcgtttt gatgacaatg ttgacaacgc atttgccaaa 1311001 acctccttaa taatttgatc atctttgacc aatgaaagtg aataaaaagg tctattgggt 1311061 ttgaccttct ttgactatta gtatacggca aacttaacgg cattcaaacc aatatgctca 1311121 aagcagactg aatatttgac tatctttgac caattgattt ttaaaaaagg ccggtttgtt 1311181 tgaccaactt tgattaatag tatactctga ctatctttga ctttcaagtc ttatgcacaa 1311241 aaatttttga tttgttacaa agtaaaacat gttttcttcg tcttttcaag gaacttgtct 1311301 cataggttat aaaaaggcat atatggacaa aactgcggtt cgttcggagg gaagaaatgg 1311361 aacaatcaaa agggtctgca agtcagcttg cttttgtgta tgtcggcaca gtagtcggag 1311421 ctggatttgc gactgggagg gaaattgttg agttttttct gaagttcggc tggttcggtt 1311481 ttttcggcat tctcgtcagc ggcggaatgt ttacgttact gggggccaag ctgatgatca 1311541 tttcaaagcg aatcaatgcc aagtcatatc aagaaatgaa catatttttg ttcggggcga 1311601 cggctgggcg gattatcaat gtatttatgc tgtttgttct ccttggagtt acatctgtta 1311661 tgctttcagg ggcaggggcg ctttttgagg aacagctggg gatgtccgct cagattggga 1311721 tgctcattac aatcggtctg agtttaattg tgatgactag aggagtaaaa ggcattttcg 1311781 gtgtcaatgt gtttgttgtt cctcttttaa tcatcttttc aatgattgtg gtggccgact 1311841 cttttatatt cagcgaatca cgaaacgcag ctcagtgggt ctggccgcat cgctgggatt 1311901 ggctgttatc agcagtttct tacggggctt taaatttatc gcttgcccaa gctgttttgg 1311961 ttccgctggc gaatgaaatg tcatcggaga aagtgataaa aaaaggcgct ttaatcggag 1312021 gcacgatgct gacgattgtg ctgtccgcga gttttctgtc tttgtcgact cttccggatg 1312081 tatttttgta tgatataccg atggcgcaag tggtttatct ctttgcacga tctgtccatt 1312141 tgatttattt actcattatt ttcggagaag tgttcacatc agttatcggt aatctatatg 1312201 gattagaaaa acaagtgcaa agctttcttc cagtgaaaag caaatatatc tttgcagcca 1312261 ttatgatcac ggcttatatt acgagccaaa tagggtacgg caggcttatt tcaacgattt 1312321 atcccttgtt tggctatgtg agcctggcct tcataggcgc tttgctttgc aaaaaagctc 1312381 ctcggcggcg cagtttataa atatatataa tgaaacgaac cgtcactata gagcgataat 1312441 tgatctagga accggggact gactttttta ttgtcaagaa aaacatcatt atggtaagat 1312501 agcagaagtg aaaaaattga agaaaatccg tgcgatatgc gggagaggtt ctagctacac 1312561 cctctataaa aaactaagga cgagctgtat ccttggatac ggcctttttt atgtttttct 1312621 agagcacctt ccgaaaaaag gtgttttttt gcgtgaatta gctgtagcga tgtctctcgc 1312681 cggcgttttt attgcggaga aggagaggaa tcatgaaaaa agaaaaagca attgtcgtat 1312741 ttagcggcgg tcaagacagc acaacatgct tactgtgggc cttaaaagaa ttcgaagaag 1312801 tcgaaacggt gacttttcat tataatcagc gacattcgca ggaagttgaa gtggcaaaat 1312861 ccattgcgga aaagcttggt gtgaaaaatc atttgcttga tatgtcactt ttaaatcagc 1312921 ttgcaccgaa tgccctgact agaaatgata ttgagataga agtaaaagac ggcgaactgc 1312981 catccacatt cgttccaggc cgcaatttgg tattcttatc ctttgcgtct atcctggctt 1313041 accaaattgg cgcgcgccac attattacag gagtttgcga gacagacttc agtggttatc 1313101 ctgactgccg tgacgaattc gtgaaatctt gcaatgtcac ggtaaatctg gcaatggaga 1313161 agccgtttgt gatccacacg cctctcatgt ggctcaataa ggcggaaacg tggaagcttg 1313221 cagatgagct tggcgcgctg gattttgtga aaaacaacac gctgacatgc tataacggca 1313281 tcatcgcaga cggctgcggc gaatgtccgg catgtcacct tcgttcaaaa ggttatgaag 1313341 aatatatggt gatgaaagga gagcgtgcat aaattgttat ctcaaattta tccgcaggcc 1313401 cagcatcctt attcgtttga actgaataag gacatgcata tctcagccgc tcattttatc 1313461 cctcgggaaa gtgcgggagc gtgcagcagg gttcacgggc atacgtatac cgtaaatata 1313521 accgttgccg gcgacgaact tgacgattca ggctttcttg tcaatttcag cgtactcaaa 1313581 aaactggtgc acggaaacta tgatcacacg ctattaaatg atcatgaaga tttttctcag 1313641 gacgaccggt attcgctgcc gacaactgaa gtcgtggcga aaacgattta tgacaacgta 1313701 caggcttatt tagacacttt ggagaataag ccgacctgtg tacaggtgtt tgtccgtgaa 1313761 acaccgacaa gctactgtgt ctaccgtccg aaaaagggtg gtttgaatgg ctaaaggaat 1313821 tcctgtatta gaaattttcg gcccgacgat tcaaggagaa ggcatggtga tcggacagaa 1313881 aacgatgttc gtccggacag ccggctgcga ttattcctgc agctggtgtg actccgcttt 1313941 cacttgggac gggtctgcta aaaaagatat tcgctggatg acggcggagg agatttttgc 1314001 ggagcttaag gacattgggg gagatgcgtt ttctcatgtg acgatctcag gcggcaaccc 1314061 ggctctgtta aaacagctgg atgcttttat tgaactgctg aaggaaaata acatccgtgc 1314121 agcgcttgaa actcaaggga ccgtttatca ggattggttt acgctgattg atgacctgac 1314181 aatttctcca aaaccgccaa gctcaaaaat ggtaacgaac tttcaaaagc ttgaccacat 1314241 tttaacttca cttcaagaga atgatagaca gcatgctgtc agcttgaagg ttgtcatctt 1314301 taatgatgaa gatctggaat ttgccaaaac tgtgcacaag cggtatccgg gaatcccgtt 1314361 ttatttacaa gtcggaaatg atgacgtgca tacgacagat gatcagtcac tgattgcaca 1314421 tttgcttgga aaatatgaag cgcttgttga taaggtagct gtcgatgcgg agctgaatct 1314481 cgtcagagtg ctcccgcagc tgcacaccct gttatggggc aacaaacgcg gagtataata 1314541 gaaaggaaga tgaacatgac gacaagaaaa gaatcagaat tagaaggtgt aacattgcta 1314601 ggcaatcaag gtacaaatta tttgttcgaa tatgcaccgg acgtgctgga atccttccct 1314661 aataaacatg taaaccgtga ttactttgta aaattcaatt gcccggaatt cacatcttta 1314721 tgtcctaaaa caggccagcc tgactttgcg acaatctaca tcagctacat tcctgatgaa 1314781 aaaatggttg aaagcaaatc attaaagctg tatctattca gcttcagaaa ccatggtgac 1314841 ttccacgagg actgcatgaa tatcatcatg aacgacttga ttgaattaat ggacccgcgc 1314901 tacattgaag tatggggcaa attcacgcca agaggcggaa tttccattga tccgtacaca 1314961 aactacggaa agcctggcac gaagtatgag aaaatggccg aataccgtat gatgaaccat 1315021 gatttgtatc cggagacaat tgataatcgt taattattcc gttgtgtgat acggagtgta 1315081 aaaggaagtg gagtcacagt aaaatccgaa cattcagcgt taattttcag cggaaatgtg 1315141 acctggtcac agcgaagtgt gacccgcact aagctcaata aaagtgggaa aagtcacacc 1315201 tgaaaatggc tctactcatg ggaattgtat taaaaagtgt gacctgaggt gcaacctgaa 1315261 ctgtgacttt tatgcagtga aaaattgata gtacagaagc agattaaggc gtacaatttg 1315321 tacgtctttt cttttttatc cgaaagaaaa aatgcctatc tagagatcat aggcattaaa 1315381 tattattatc aatatcttca tttatttttt ggctaagttt ctgaaccttc tctttaacat 1315441 ttgaaacagc tcttttttga atttcatcaa ttctcctgaa tatagtcgat gacacttctt 1315501 attagaactt cactttcaaa attgaatatc tcatttattt ctgactgttc ttcatctgtt 1315561 aggtgatggt attgaagttg tttagcattt acttcagcag ctacatcaat cctaacttag 1315621 ttgttctggt tgtacaattt catattcacc ttctgcatac tcttgctccg cataatagcc 1315681 tccccattga cagagctcct gcaagatagg tttaagagat tctccaagtt cagtggatga 1315741 atattcaacc ttcggcggta cttgattata catctttctg ctcacaagtc cactggcttc 1315801 aagctctcta agtgtttgaa tcagcatttt ctgagttata tttgggataa tgcgctttaa 1315861 ttcactcgtt ctctttggtc cattcattaa aaagtataat acaaggcctt tccattttcc 1315921 gccaataact tcctttgtca cttcaaaccc acagctaaat tttttcatgt ctaaagctct 1315981 ccattccaca tttattactt tttagttact atatcacaaa aaagtgggta cttccgataa 1316041 tgtgcttact gaaggatact atatcttgta agttgttctt caagtactta aaggtactag 1316101 acataaaata aaattaattc taaaggagtg ttaagtatgg gtaaatttga aggtaaaata 1316161 gcgcttgtaa cgggtggaac aagtgggatt ggtcttgcta cagcacaaaa atttgtaaac 1316221 gaaggtgcat atgtttatat tacgggacgt agacaaaacg aacttgataa agctgttaac 1316281 caaattggca agaacgtaac cggtgttcaa ggtgatattt ctaagcttga agacttagac 1316341 aaactatatg acattataaa gcaggaaaaa ggtaagttgg acattctttt tgctaatgca 1316401 ggcatcggca acttccttcc attaggtgaa attactgaag agcaggttga tagaacgttc 1316461 gacattaacg ttaaaggaac catctttact gttcaaaaag cgttatcact attcccggac 1316521 aaagtaggtt ctattattgt aacgggctct actgctggat caattggcaa cccagcgttt 1316581 agtgtatatg gagcatctaa agcagcatta agagcactag ttcgcaactg gattcttgac 1316641 ctaaaaggta ctgaaatccg tgtaaatgtg gttagtccag gaggtattct tacacctgcc 1316701 tacgatgagc tttttggtga tgcacttgaa gaggtactgg aaaatagcag aaatactgtt 1316761 ccagctggaa aagttgggac acctgaagaa gtagcaaacg ctgtatcttt ccttgcttca 1316821 gacgaaagca gttacttgac gggtgttgaa ttgttcgtag atggcgggct agcacaggta 1316881 taatttcact gcgcagagat tacaaatagt ccccaaaaaa ggttaatggg gatttacttg 1316941 aagaagtcgt ataaaaaagt cgttttcctt aaaggacagg gaattcgact tttttatatt 1317001 tgaatttgat taacgttgta aattcgcatt ttcctggggc tactactaaa tgacctgtaa 1317061 aaaagattac actgtgaata aatgtactta aagtaacggg ggctcttgac ttttaataaa 1317121 aaataatatc cctgtccttg tattctaata cttttaaaaa tatttaaagg aatccttatg 1317181 tcctgaataa ccacatagga aaatatgttg taggttgctt tctttttttg tggggcatcc 1317241 cacacaagct atctcgtgat ctcacacctg aacgtttttt atagactagt accgcgacaa 1317301 gttatattac atatacatac caataaagta gacattaaaa agtgaaagag aggatggaaa 1317361 tgtgtgaaaa ttcttttcct tgagagtcat cccatgtggc tctatggttt accgaatggg 1317421 tttagggaag caggacatac cgtaatgatt tccggtcctg taagtcggga aaatataact 1317481 gaaatgatag acgaatttaa accagattta atagtatcta tgggatggac accagagcat 1317541 tcaagggaaa agcaggcctg gattcgcaac gctactaaaa aggtgaatat ccctctcgtt 1317601 tattgggcaa ctgaagaccc gctgcacact caaaacttta ctatcccgtt aattaaaaag 1317661 atgaaaccgg attttgtttt cacggtcacg ccttctctgt gtaaaactta tgaaagcatg 1317721 gggattaaag cagctcactt agactttgca tttcacgaaa gtatacatca ccagattaaa 1317781 ccattagcga aatacagttg tgatatagca gtggtggcta atgcttaccc taattttctt 1317841 gaagaacatc cggaagtgtt ccgttcgtcc tctttaaaaa cgcttattcg tcctcttata 1317901 cggaagggta ttcgcattga tttttggggg agaaactggg aaaaaatgag taaatatata 1317961 ggaagagaaa ttccccgcaa ttggatccat ggataccttg attatactga agcatataaa 1318021 gtttacagtt cagcaaaaat cattatcggt ttgcaaaact gtgaaagcca acttacacaa 1318081 cgcacctatg agattcttgg ttccgggggg tttttattga catcggatac accagcagtt 1318141 cgaggtaaat tcaaacctgg ccgcgatctc atcgtttctt cctccccaaa agaaacattg 1318201 gaaaaggtta aatactattt aaatcatgat agcgagagaa aaaagattca gataaacggt 1318261 aaaaaggctg taaagaatga ttcctatcgg catagagccg agagaatgct tgaggtgcta 1318321 aaaagcagag gaatcataag aaacttaggg gaaaccattc attatgtaga tgttctcaaa 1318381 gaaaaatacg tgatccatca tgttactccc ggtgaaacat tatcaataat tgccagtaag 1318441 tataatgttt ccctgcagca actcatggag cttaatcatt tcaaatcaga tcaaatatat 1318501 gctggacaaa tcattaagat tagagagaaa ctgtttagaa atattaataa caaattattc 1318561 taaaggagag taatatgaat gaaggggaaa atacctaaaa taagaaatca agcgaataaa 1318621 gtaaaaagaa cgcctcgtta tatggaattt cccgtgacat acgaagtata tcatgtggaa 1318681 tccggcgata cattatggac gattgccaaa tcctttgaaa ttccggtaca acaacttatg 1318741 aatcttaata agctttcttc agatagaatt tatcctggac aaattataaa gataagagaa 1318801 agataatctt tgaggtttcg gaagcgaatc aaattgaaat gacaatcctc atttttttat 1318861 ttgtggggaa cttgatattt ttggggatga aggggttatg agatgtttca aatgagctat 1318921 tactattctg gattaggatg ggactttatt caacacgttg atcaaacgaa cggagtatta 1318981 aatgttgtgt ctcctgattt tttctatatc agaaaagatg gatcattact tctccgttca 1319041 gctaatcccg atgtgattaa agctcttcat agaagaaaat taaaagtagt tccttttcta 1319101 agcaatcatt gggatcagga tttgggacga tttgcattaa tgaaccgagt tcttttagct 1319161 aaacaaattt ctcatgcaat agaagaactg gatttggatg gagttaatat cgatatagaa 1319221 aaccttacag aaaaagatcg gaatctattt acagatttta ttagattagt aaggaaaagt 1319281 attcctagac ataaagaagt atcagttgca gtggcggcaa atccttttgg ctggacgaag 1319341 ggctggcacg gatcatatga ttacgagtat ttagctaaat atgcagatta tcttatggtt 1319401 atggcctatg atgaaagccg ccttgctggg cctactgcaa gtgtaggatg ggtggaaaag 1319461 tccattcaat atgttctgac ccaaaaaatc tctcctcaaa aactagtttt aggattgcca 1319521 ttctatggcc gctgctggat ggaaggccaa tctgcctctc aagccattcc cctttacctt 1319581 gttgttagta aaaaggcata gcgggacaat tatttttgac accaagagtc aatctccaaa 1319641 agctattttt actgtcaatc acgataaaaa ggggccgttg ccttcgggaa catatacatt 1319701 atggtttgaa aatgaacagt cactcagagc aaaaataaaa ctcgctcaaa aatataatct 1319761 gaaaggtctt ggcagctgga gtcttggaca agaagatgcg tcagtctgga atacagtgtt 1319821 taaaaatata taatgattta tagttcagaa caaaattcga agataattgc aatgaatctc 1319881 taaatggaca tactgaaagg agtttattac gagtgcgggt aaaacagtga gggcattcca 1319941 taggcccttc tcccaaaatg ttctacacga ggcattacat tgggcttgaa atacacattc 1320001 aaacttatgt tatagtacgc attttacgga tgtgttgaat ttattctgct tccatgattt 1320061 aatcatacac atgctacttg atagcagggt tatcgcattt cattcagaat tgttcaggat 1320121 cgatatggaa gcgcacgact aactagaact ttaaaagcat acactcatat acttcctgaa 1320181 tggatgctgg tttatctaaa aaacatgatg agaattgatt gtacgcatgg tgaagcatga 1320241 cttgttgata atcgaccata tggtttctcc ttagaaatga gggggttttt acataaaaaa 1320301 gacgagcgaa tccgggggga attccactcg ccgctttcta atgaaaagac gggatgctgg 1320361 atggcagctc gtctgtttta ttataattta acgaacgtat gtttgtaaag gtgtcttttc 1320421 gaatgaattg gttcatataa ccgttaagaa cagattcatt gtaaacattc gctaaggtat 1320481 gctaagatgc atggactata aaggagtgat atgaagtgaa gacattgcgg ttaaacaatg 1320541 taacgttaga aatggctgca tatcaagagg agagcgagcc gaagcgaaaa attgcattta 1320601 ccttaaacgt tacgagtgag acttaccatg atatcgctgt cctgttgtat gaaaaaacgt 1320661 ttaatgtcga ggttccggaa cgcgatcttg ccttccgggg ggaaatgaca aattattcaa 1320721 catcattgac caacctgtac gaaccagggg ccgtcagcga gttctatata gaaataacgg 1320781 aaatagacaa aaacgccgat tcatgatcgg tgttttttat gtaaaaaagc tgccggccgg 1320841 cagcttttga gaaagcgaat ttcatatgta aggtgttaaa ttgtccgtct tgcagttttt 1320901 tgaataaatg tggaaataag gaggttttaa taggagtctc tgatgatctt ataattttta 1320961 tgattaacaa ctgtcaatga atctaactca agatcccgat agttatccat gatcgtcaca 1321021 tcaacgataa cagaattctc atttactttt tcaacaacac cggttaatcc gtttttaaat 1321081 tcaatgacat tcccaacctt agcgattttc acaagcttcc tctcctttaa acataataat 1321141 gccttttgaa agtattttgc agtattttca ttgagaagta aagcgataag gagttttatc 1321201 tcccttatga attgttctgt cgctataaag atgatatatt gattttcgtc aatagaaaga 1321261 aaagggggga atttttgttg cgtcccgaag aaataacaga aatgattgaa cagctgcgca 1321321 ccggcgccat aaacgaactg agagtccaga aagagcattt tcttgatttc agggccgtgt 1321381 tatctaaaca agatgatttt aaacatttcc gaggaattgc ccagcaaggc ggagatgtta 1321441 tctttcaata cttagaacag ccaagaagct gaaggtttct catacgtgag aagccttttt 1321501 atcatatatg acagaacaca agccttttat tacagctgtc tgtaacaggt gtaaataaaa 1321561 tgtaaagtac caaagatgga taaacatgtt ttaatttaac aatatttata gaatttcaga 1321621 ctgttttttt gccattaagc agtgagtcat cctctttatt ccatcctgat acctccttgg 1321681 gagagttgga aaatcttttt ccgtgaaaat gaatggatct cttgttaagg ttatgaagtg 1321741 ttttttggag cactttaagg aggaaactgt atgacaacga aattcactgc tctggctgtt 1321801 tttcttcttt gtttcatgcc tgcagccaaa attgagcata cacaagcttc actactgagc 1321861 gcaaagaaga caaaacatga agaagcgaaa tggcttacac atatagatcg aaatacgaat 1321921 gaatctttcc cttcactgtc tgctgataaa gacaagaaaa taaaaccgat taagctatca 1321981 gcacacactg aaaagaaaga gaaagataaa ccggacaaaa caaatgatga gaaagaaaca 1322041 tatacacagt ctgaaaaaga gttgctgtcc cgtctcgttc acgcagaggc caaaggagaa 1322101 tcatataaag gcaaggtcgc tgtagcaagc gttgtactga acaggacgga gaaaaaaggt 1322161 tttcctgata cgataagagg agttatttat cagaaaaacg cctttgaacc ggtcgcaaac 1322221 gggagcatta accaaaagcc tgataaagaa tcgattgaag ctgccgaaga agcgctgtcc 1322281 tcaaaaaata gagaaacaga tgccatattc ttttataatc cgaaaacagc gtcagataat 1322341 tggattcgtt caagaaaaat cgtagaaaaa atcggcagac acgtttttgc cgtctaagca 1322401 tagaagagac aatttgtctc agctgtgctt tttttcatat aaagagtaaa aataaaataa 1322461 tttttgaact tgtctcatat gatgttggta gtacaagaga caaggagaga catcatgaat 1322521 cgatttgtga aagggatcat tcttttatcc attgccgcct ttttcgctga atgccttgaa 1322581 tttgtcgtca atatgatttt ggcgcgggag cttggcgagc atgggatggg gctttacatg 1322641 agtattttgc ccacgatctt tttaattatt gtcatcgcga gcctggaact gccgatatcc 1322701 atttctaaat tcattgccga gtcaaatcct aagcttcatg aaagcatgct gaggcacgct 1322761 ttcagaatga cagccatttt tactgctttt tctactgccg ccgctagtat tgcgcttccg 1322821 tttattccgg tatttgatac ataccacccg tttattaaag ggattgtcat cggcttaatt 1322881 cctgttgtcg cctttacttc aatcgccagg ggctacttta tgggtgtgca gaaaatgggg 1322941 aagatcgcaa ttgccaatgt gctgaaaaaa atcatccagc tcttgtgctt attcctcttt 1323001 tttcaatggt actcatttga attggacatg gctgtgctga tttccttgtt tgttctagtc 1323061 gtgagtgatg tggtcgtgct tgtttattta tattcacaat ttatcatggc aaggcgggcg 1323121 ttatccggcc agcagcacat tcatttgcgc ggaaaggatg taaggaaaag actgcttgct 1323181 gtttcaattc ctacaacagg actgcgtatt tttcatgcgg ttgtcaatgc aattgaaccc 1323241 tttttagtaa aaggagctct tttggctgcg ggcgttgccg ggacagcggc gatcgatcaa 1323301 tacggaatgc tggcaggagt ggctgtgacg atagggtcgt tccctgcttt tattgcccat 1323361 tcgttaatgg tcgtcatgat accgagtatt tcggaagctt atgcactttc tcagtatgac 1323421 atcgtgttaa aaaggctgaa gcagtcgatt ttcattacat taggttacgg tatacctgcc 1323481 gtctgggtca tgttccagtt tgcgggacct ctcacgcatt tgttttttca ctctcctgaa 1323541 gcgcagtatt acttgcagct gttgtggcct tactttctct ttcatctgtt tgtcatgccg 1323601 ctgcaggcgt gcttaatcgg gatgggtttt gtgaaagagg ctttttatca caatgtatgg 1323661 agccatatcg ttgcgctaag tatgatgtat gtactgggat caatggagaa tctgcaaatg 1323721 ctcgggatta tccttggaat gaacactggc atgattcttt tgacgagcct gcactatgcc 1323781 acgatctgca aagcattgaa ggtatctgta tttcttacgg gagggaccag aacgccgcga 1323841 attgaaggat gataaaggaa cagcaggggc aagctaattg aaaagcatga aaggaagatt 1323901 ccatgttgac gaagcgcttg cttactatat acattatgtt attagggttg attgcatggt 1323961 ttccaggtgc ggcacaagct gaggaaaaac agcctgctgt tcccgctgtt tttcttatga 1324021 aaacgataga aggggaggac atctcgattc cgaataaagg gcaaaaaaca attctccatt 1324081 tttggacgtc atggtgcccg ccctgcaaaa aggagcttcc acagtttcaa tcgttttatg 1324141 atgcccatcc atccgacagt gtaaagctgg taacggtgaa tttagtgaat tcggaacaaa 1324201 atcagcaagt cgttgaagac tttattaaag caaacaagct gacgtttccg attgtccttg 1324261 actcaaaagg ggaattgatg aaggagtatc atatcatcac gatcccaaca tcatttttgc 1324321 tgaatgaaaa gggagaaatt gaaaaaacaa aaattggccc gatgacagcg gaacaactga 1324381 aggaatggac ggaagaatag ctgagagcat agactctcag cttttttcat atagagaaga 1324441 agtgaataaa cattaatgat aattattatc aaaaagaaat taaaataatt ataattgaaa 1324501 ttctcttcgt gcgtgctata ataaaggaag acatcaagaa ataactgacg ataaagctgc 1324561 cttttgggca gcgattttgt ttttataaga gaaatgaaga tgatttacgt tctcaattag 1324621 agaggagaat tcgatatgaa tgaacaagtt atcgttcaac gcgacccgca tgagccattg 1324681 aaaacagaca agagggaaaa aaactgggca cagcacgcgg agcttattgc agcacttgta 1324741 tcaggcgctc ttattttggc aggctggctc ttatccggat atcaggtatt atccataata 1324801 cttttcttgc tggcttttgt gatcggcgga tttgctaaag cgaaggaagg aatcgaagaa 1324861 acactcgaat ccaaaacgct gaatgtagaa cttttaatga ttttcgctgc cattggttcc 1324921 gccttgatcg gatactgggc agagggtgct attttaatat ttattttttc cttaagcgga 1324981 gctttagaaa catacacgat gaataaaagc agcagagatt taacgtcttt aatgcagctt 1325041 gagcctgaag aagcgacatt gatggtcaat ggtgaaacca aaagagttcc ggtttcagac 1325101 ttgcaggccg gtgatatgat tgtgatcaaa cctggagaac gcgtagcggc agacggtatc 1325161 attgaatcgg gctcgacaag tcttgacgag tcggctttaa caggtgaatc aatgcctgta 1325221 gaaaaaaaca caggcgacac tgtattcaca ggaacggtga atcgcaatgg ctccttgaca 1325281 gtccgtgtca cgaaagcaaa tgaagattcg ttattcagaa aaattatcaa actggttgaa 1325341 tcagcgcaaa atagtgtttc acccgcgcag gctttcatcg aacgatttga aaatgcttat 1325401 gtgaaaggtg tgctaattgc ggtggcgctc cttttattcg tcccgcactt tgcgctgggc 1325461 tggagctgga gtgaaacctt ctaccgcgca atggtgttta tggttgtcgc gtcaccttgt 1325521 gcgcttgtcg cctctattat gccggcggcg ctgtccctga tttcaaatgg cgcccgcaac 1325581 ggtatgcttg tgaaaggaag cgtctttctt gaacagctgg gctcagtgca aatgatcgcc 1325641 tttgataaaa ccggaactgt aacaaaaggc cagcctgccg tagagacgat cagaatagca 1325701 gaaggattca gtgaagcgga agttcttgag gctgtctatg ccatcgaaac gcaatcaagc 1325761 catccgctcg cccaagccat aacggcgtac gctgaaagcc gcggcgtgaa tcagtccggc 1325821 tacatatcta tagaagaaac ctcagggttt ggcgttatgg cagaagtgtc gggtgcgaaa 1325881 tggaaggtcg gtaaagcagg ttttatcggc gaggaaatgg cagcacaatt tatgaaacaa 1325941 acagcatcag atgtcattca aagcggtcat acaattgtat ttgtgaaaaa ggatgatcaa 1326001 atagcaggct gtatcgcact gaaggaccaa atcaggcctg aagcaaaaga ggtcatggaa 1326061 gaactgaacc gacttgggat taaaacggcc atgctgacag gagatcacga agacacggct 1326121 caagcgattg ccaaggaagc cggcatgaca actgtcgtgg cagaatgcct gcctgaccaa 1326181 aaagtgaatg aaatcaaacg gttaaaagaa gaattcggaa cgattgcaat ggtgggtgac 1326241 ggaatcaatg atgcgccggc actcaaagca gcggatgtcg gcattgcgat gggcggcgga 1326301 acagatgtag cacttgagac cgctgatatg gtcctcatga aaaacgattt gaaaaagctc 1326361 gtaaacatgt gccgcttgtc tcggaaaatg aacaggatca tcaaacaaaa tatcgtgttt 1326421 tctctagctg taatctgcct gctgatttgt gcaaactttt tgcaggcgat ggaattgcca 1326481 tttggcgtga ttggtcatga gggcagcacg attttagtca tactaaacgg tttaagactc 1326541 ctaaaataaa accagcagcc taatcaggct gctggctttt tatgtatcaa gctttccctt 1326601 catttttgtc tttatcagat cttttcataa ctaggatgag agcgagggtg cagcaaagga 1326661 aacccgctgc acagcctatg atagagctgt aataataaaa gcccaccatc ttcatcccga 1326721 taaaaggagc ggaaattccc aaaaccgtta agagcataac tgcttttcgt ctgaaaaaat 1326781 tcatcagcaa acggaacaac ccccctgcga ttgaacgtta ctgtcagtat acaggaagag 1326841 gagcaggaaa taaaatgcat tagaaaatga aggcgtcgtg aaaggcaaac accggtaaaa 1326901 cctgttacaa tggaagacag aacaatgcat tgcaaatggc agggaggaac aagaagtgaa 1326961 tagaatacaa cgcgtctctt catggctgaa ggaagcgggg catactgccg catttattca 1327021 tacgaaagaa aatgtttttt acttaaccgg tttttacaca gagccgcatg aaagattaat 1327081 ggggttattt atttttcaag aagaggagcc tttctttgtt tgtccaggaa tggaagcagg 1327141 acaggcccgc aacgcaggct ggaatcatga aatcattggc tatgcggatc acgaaaatcc 1327201 gtgggagctg atagagaagg ctttgaaaaa gcgaaatatc agcatacata tgcttgcggt 1327261 agaaaaggat tcaatctcgc tgtcacgtgc agaacagctg aagcatgcga cgggcggggc 1327321 tcaatttgtt tcagcagaag aaacactcaa tcaatttcgc ctgattaaag atgacaatga 1327381 gattcgtttg ctgaaagagg cggcaaagct tgcagattac ggtgttgaag tcggcacagc 1327441 cgctttgcgt gaaggcatca gtgaagtgga agtgctcgct caaattgagt atgagctgaa 1327501 gaaaaaagga attcagggca tgtctttctc tacaatggtt ttattcggag aaaaatctgg 1327561 ccagcctcat ggaaatcctg gtacagccac gttgaagaaa ggtgattttg ttttatttga 1327621 tctcggtgtt attcttgatg gctattgctc tgatattaca agaacgtttg catacaaaac 1327681 catcaatccg aagcaggagg ccatttacga gactgtgctt caagcggaaa aagccgcgat 1327741 tgaggcaagc aaacccggtg tgagaatcgg agatctggat ttaactgccc gcggaatcat 1327801 tgaaaaagcg ggatatggtg attattttcc tcaccggctt gggcatggac tcggaatttc 1327861 agtccatgag tatccatcaa tgagccaggc caacgataca ctgctgcagg aaggcatggt 1327921 ctacacgatc gaaccgggga tttatgtgcc agagatcggc ggcgtacgca ttgaggatga 1327981 cgttcacgta acaaaggacg gagcagttgc tctgacccaa tatccaaagg atttgatcat 1328041 actgtaatag aaataaaaaa ggactttgtt ctcgacatcg tcctttttta tctgcattaa 1328101 ataaaaaaat catcaaatgt tcgaaagggt ttaatttcat gtttttggtt gagaggtttt 1328161 acagcaagac agctgccacc gagaacagtg agacataacc caattaaaat gaagaaaccc 1328221 atgtgatctt ctcctttcag ctaaaaacac aaaaagatat ctggtacgtc catatcatat 1328281 tgtatgaaac gcattccaga tcaaggggat ttagaaagaa gggaatctat ggctaatatt 1328341 aaagacattg cagagaaagc cggtgtctct gttacaacgg tttcccgagt cataaacaat 1328401 catccatacg tcagtgaaga caaacgaaaa agagtgtttg aggcaatgga atcattggag 1328461 tacacgagaa atattcacgc tgtacatttg tcgaaaggat tttcaaacat gattggtgtt 1328521 gtcttgccga cggttaatct gccatatttt gcagagctga ttgcaggaat agccgacgca 1328581 gccgcggaat ccggggttca cctctcttta ttccaaacaa actatgaagt acaaaaagaa 1328641 atctttgcgc tgtcccaatt aaagcagcgc caggttgacg gcctgatttt ttgctcaaag 1328701 gcgcttgctg atgagaaact catggaatgg gagggcccga ttttgctttg ccagaattca 1328761 gataatgccc gcttcccaac catcagcatt cctcaccaag aagcatttcg gaacggcttg 1328821 gactatttaa ttgccaaagg gcacaaaaaa atagccatct gtttggcaag aaaaaaaggc 1328881 atgaacagcc attttcgaat caaagcctac aaagaggcat tggaagagat cggcgaggca 1328941 tttcgtgaag actgggtaat tgagaaagcg attacaatca atgatgggaa ggcgcttttt 1329001 cataaatgga atacgtggaa ggaaaagccg acggctattt ttgttgccaa tgaccaagtc 1329061 tcagcagggc tttttcttga agcaaagaac cagcgggtgt cagtaccgga tgagcttgca 1329121 atcttaagcg ttgataacca cgaaatcagc caagcgcttg gaatcacaac gatcgatatt 1329181 cagacaaggg aaatgggaaa gcaggcattt gccatattgg aaaaaagaat tcaaggacag 1329241 ccgattgaaa ggaaagttct ggattaccgt ctcatcgaaa gatcgactgt ttagtgaatg 1329301 cattgaaaaa aggtttgacg tgcattctgt tcgttatgta cgatatgagg tattgaatga 1329361 caaaggagct gaggatcgtg aatgggtcct tcacagtgaa aaaggtactg aataataacg 1329421 tattaattgc ttctcatcat aaatacagcg aagtcgtttt aatcggaaaa ggtattggtt 1329481 tcggaaaaaa acaagatgat gtcattgaag ataaaggcta cgataaaatg ttcattttaa 1329541 aagacgagaa ggaacaaaag cagtttaaaa agctccttga ctatgttgat gaaaagctcg 1329601 ttgatatttc aaacgatgtc atctatcaca taagcaatag gacgaatcac tcattaaatg 1329661 aacatattca cattgcgttg acagaccata tcgcatttgc gatcaaaagg cagcagcagg 1329721 gatttgatat gaaaaatcca tttctaatgg agactcagtc actatatcct gaggagtacc 1329781 aaattgccaa agaagtcata gatatgatca atgaaaaagc gggactctgc cttccggaag 1329841 gggagattgg ttttatcgct ctgcatatcc attcagcgtt gacaaaccgt ccgctgtccg 1329901 aggtcaatca gcactctcag ctcatggcgc agcttgtcga ggtgattgaa gactcatttc 1329961 aaatgaaagt aaataaggaa agtgtcaact atttgcggct gatcaggcat atcagattta 1330021 caatagaaag aattaaaaaa gaagaaccga ctaaagaacc agaaaaatta atgttgttat 1330081 tgaaaaatga atatccgcta tgctacaata cagcttggaa attgattaaa atcttgcagc 1330141 aaacattgaa gaaaccagtt catgaggcgg aagcggttta tctgacgctt catctgtacc 1330201 gattaaccaa taaaatttca taaattcagt ttatccttat aacgtgttac tgattcgatc 1330261 aggcatgagt gattgaggga aaaaaacggg aagttcattc tcgttctttt gcgcacccaa 1330321 ttttgctcat gcctttttgt tgtgtaaaag ggcaaatgta aacggttaaa ctggaagact 1330381 tacgcctgtg aattcgttgt catgattttt agctgtaagg tcagactagt aaaaagagga 1330441 ggtcaattct tatgtttaaa gcattattcg gcgttcttca aaaaattggg cgtgcgctta 1330501 tgcttccagt tgcgatcctt ccggctgcgg gtattttgct tgcgatcggg aatgcgatgc 1330561 aaaataagga catgattcag gtcctgcatt tcttgagcaa tgacaatgtt cagcttgtag 1330621 caggtgtgat ggaaagtgct gggcagattg ttttcgataa ccttccgctt cttttcgcag 1330681 taggtgtagc catcgggctt gccaatggtg atggagttgc agggattgca gcaattatcg 1330741 gttatcttgt aatgaatgta tccatgagtg cggttcttct tgcaaacgga accattcctt 1330801 cggattcagt tgaaagagcc aagttcttta cggaaaacca tcctgcatat gtaaacatgc 1330861 ttggtatacc taccttggcg acaggggtgt tcggcggtat tatcgtcggt gtgttagctg 1330921 cattattgtt taacagattt tacacaattg aactgccgca ataccttggt ttctttgcgg 1330981 gtaaacgttt cgttccaatt gttacgtcaa tttctgcact gattctgggt cttattatgt 1331041 tagtgatctg gcctccaatc cagcatggat tgaatgcctt ttcaacagga ttagtggaag 1331101 cgaatccaac ccttgctgca tttatcttcg gggtgattga acgttcgctt atcccattcg 1331161 gattgcacca tattttctat tcaccgttct ggtatgaatt cttcagctat aagagtgcag 1331221 caggagaaat catccgcggg gatcagcgta tctttatggc gcagattaaa gacggcgtac 1331281 agttaacggc aggtacgttc atgacaggta aatatccatt tatgatgttc ggtctgcctg 1331341 ctgcggcgct tgccatttat catgaagcaa aaccgcaaaa caaaaaactc gttgcaggta 1331401 ttatgggttc agcggccttg acatctttct taacggggat cacagagcca ttggaatttt 1331461 ctttcttatt cgttgctcca gtcctgtttg cgattcactg tttgtttgcg ggactttcat 1331521 tcatggtcat gcagctgttg aatgttaaga ttggtatgac attctccggc ggtttaattg 1331581 actacttcct attcggtatt ttaccaaacc ggacggcatg gtggcttgtc atccctgtcg 1331641 gcttagggtt agcggtcatt tactactttg gattccgatt tgccatccgc aaatttaatc 1331701 tgaaaacacc tggacgcgag gatgctgcgg aagaaacagc agcacctggg aaaacaggtg 1331761 aagcaggaga tcttccttat gagattctgc aggcaatggg tgaccaggaa aacatcaaac 1331821 accttgatgc ttgtatcact cgtctgcgtg tgactgtaaa cgatcagaaa aaggttgata 1331881 aagaccgtct gaaacagctt ggcgcttccg gagtgctgga agtcggcaac aacattcagg 1331941 ctattttcgg accgcgttct gacgggttaa aaacacaaat gcaagacatt attgcgggac 1332001 gcaagcctag acctgagccg aaaacatctg ctcaagagga agtaggccag caggttgagg 1332061 aagtgattgc agaaccgctg caaaatgaaa tcggcgagga agttttcgtt tctccgatta 1332121 ccggggaaat tcacccaatt acggatgttc ctgaccaagt cttctcaggg aaaatgatgg 1332181 gtgacggttt tgcgattctc ccttctgaag gaattgtcgt atcaccggtt cgcggaaaaa 1332241 ttctcaatgt gttcccgaca aaacatgcga tcggcctgca atccgacggc ggaagagaaa 1332301 ttttaatcca ctttggtatt gataccgtca gcctgaaggg cgaaggattt acgtctttcg 1332361 tatcagaagg agaccgcgtt gagcctggac aaaaacttct tgaagttgat ctggatgcag 1332421 tcaaaccgaa tgtaccatct ctcatgacac cgattgtatt tacaaacctt gctgaaggag 1332481 aaacagtcag cattaaagca agcggttcag tcaacagaga acaagaagat attgtgaaga 1332541 ttgaaaaata agggtgttag tacgccgtgc ttgtcagatg acaagtacgg ttgtatgata 1332601 taatattgtg aagtaataaa gctttaagtt aaaaggagaa tgataaaaat ggcacaaaaa 1332661 acatttaaag taactgcaga ttctggaatc catgctcgtc ctgcgacagt tcttgtacaa 1332721 actgctagca aatacgacgc tgacgttaat ttagaatata acggcaaaac agttaacctt 1332781 aaatctatta tgggtgttat gtctttaggt atcgctaaag gcgctgagat cacaatctct 1332841 gcttccggag ctgacgaaaa cgatgctctt aacgctttag aagaaacaat gaaaagcgaa 1332901 ggactcggcg agtaatgcaa gaattaaaag ggattggtgc ttcagccggc atcgcgattg 1332961 caaaagcgta ccggcttgaa gagccagatt taacggttga aaagaaaaac atctctgatt 1333021 ctgaagcgga agtaagccgt tttgatgaag cgattgcacg ttcaaaagaa gagctcgaaa 1333081 aaatcaaaga gcacgctttg aaagaactgg gtcaggataa agctgatatt ttttctgctc 1333141 accttttagt tctcagtgac cctgagcttc tgaaccctgt gaaagaaaaa atcagcactg 1333201 attcagtgaa cgctgaattc gctttaaaag aaacgtcttc tatgttcgtt actatgtttg 1333261 aatctatgga caacgaatat atgaaagagc gtgcggcaga tatccgcgat gtaacaaaac 1333321 gcgtaaccgg ccacctgctt ggcgtcgaaa ttccaaaccc aagcatgatc tcagaagagg 1333381 ttattattgt agctgaagac ttaacaccgt ctgacacagc tcaattaaac cgtgagttcg 1333441 taaaaggatt cactactgat atcggcggac gcacatctca ctctgccatc atggcacgtt 1333501 ctcttgagat tccagcagtt gttggaacga aagctgctac aggcacgatc caaaacggcg 1333561 tgactgttat cgttgacggt atcaatggcg atgtcattat tgacccatct gcggaaactg 1333621 taaaagagta tgaagaaaaa cataatgctt atttggctca aaaagctgag tgggcgaagc 1333681 ttgtcaatga accgactgtc tcaaaagacg gacatcatgt agagcttgca gcgaacatcg 1333741 gtactcctga tgatgtaaaa ggtgttcttg aaaacggcgg agaagcagtt ggcctttacc 1333801 gtacagaatt cctttacatg ggaagagatc agctgcctac agaagatgag cagtttgatg 1333861 cttacaaaac ggttcttgag cgtatggaag gaaaatcagt cgtcgtgcgg acacttgata 1333921 tcggcggaga caaagagctt ccttacctgc agcttcctaa agaaatgaac ccgttcctgg 1333981 gatatagagc gattcgtctt tgccttgaag agcaagaaat cttcagaaca cagcttcgcg 1334041 cgctgcttcg tgcaagtaca tacggaaact tgaaaatcat gttccctatg attgcgacag 1334101 ttaacgaatt caaagaagca aaagcgatcc ttcttgaaga gaaagaaaag ctcgtaaaag 1334161 cgggacaggc tgtatctgac gatattgaag tcggaatgat ggttgagatt ccgtcaactg 1334221 cagtcatcgc tgatcagttt gctaaagagg ttgatttctt cagtatcgga acaaacgatt 1334281 tgattcaata cacaatggca gctgaccgta tgaatgaacg tgtatcttac ctgtatcagc 1334341 catacaaccc ggcaatcctt cgcttaatta cactggtaat tgaagcagca cacaaagaag 1334401 gaaaatgggt tggcatgtgc ggagaaatgg caggagacga gattgcgatt ccgatccttc 1334461 tcggcttagg cttagatgag ttctcaatga gcgcaacgtc tatccttccg gcaagaacac 1334521 aaatcagcaa attgtctaaa caagaagctg agtcattcaa agagaaaatc ttatctatga 1334581 gcacgacaga agaagttgtc gcgttcgtaa aagaaacatt caagtaatgt acaaaaacca 1334641 gacggcctcc ggcctgtctg gtttttttca taagtaaggg tatagaagga cacaataaca 1334701 tggctaggag ggatagtatg tcaaaccaat ttaacgcagg agatactgtt tatgtgatct 1334761 acagaaatcc gcacgccgcc aatgtagccc acataaagga agccgaaatt gtgcaccatc 1334821 cataccatga aggcgagctt tccctgttta tttatgaaac ctatcatcca ttcgcagagg 1334881 acgatgctgt gtttgcaagc tatgaagaag ctaaatcgct ttacaaagaa ctgtttgata 1334941 ttgatccgta tgagtaacaa ggaaatcatt acaactcata tcctttccgc ctagtgagaa 1335001 aagtaacgtt agtaaaggaa aaggatgtgg catcatgcag aacccatttg ttccgcagct 1335061 tgtgtatata gaaccgaggg cgctggaata tccgctgggc caagaattac aagataaatt 1335121 tgagaatatg ggtattgaaa tcagagaaac gacatcccac aatcaggtgc gtaatatccc 1335181 tgggaaaaat catcttcagc aatatcgcaa tgcgaaatca actttagtta tcggtgtccg 1335241 gaaaacatta aagtttgatt catccaaacc ctcggccgaa tatgccattc cgtttgcaac 1335301 aggctgcatg gggcattgtc attactgcta cctgcaaaca accatgggat caaagccgta 1335361 tatcagaact tatgtaaacg tcgaagagat tttagatcag gcagataagt atatgaagga 1335421 gcgcgcacca gagttcacaa ggttcgaagc atcatgtacg tcagacattg taggaattga 1335481 tcatctgaca cacacgctga agcgcgccat tgaacatttt ggccaaagtg atctcggaaa 1335541 gctccgattt gtaacgaaat ttcatcatgt cgatcaccta ttagacgcaa agcataacgg 1335601 gaaaacgaga ttcagattca gtattaatgc cgactatgtg attaaaaact ttgagccggg 1335661 aacttcacct cttgataagc ggatagaagc ggcagtaaaa gttgcaaaag caggctaccc 1335721 gctaggcttt attgttgctc cgatttatat tcatgaaggc tgggaagaag gatacagaca 1335781 tctgtttgaa aagctagatg ctgctttgcc gcaggacgtt agacatgaca ttacgtttga 1335841 attaattcaa caccgtttta caaaaccggc caaacgagtg atagagaaaa attatccgaa 1335901 gacgaagctc gaattagatg aagaaaagcg ccgttataaa tggggccgtt acgggatcgg 1335961 aaaatatatt tatcagaaag atgaagagca tgcacttcga gaggcacttg aatcctatat 1336021 tgataccttt ttccctaacg caaaaattga atatttcact taaacgggct gttgtgatca 1336081 acagctcgct tttttataaa aaacattttt ccattccatc aaaacgccgt aattcaatga 1336141 ttctttatcc tccaaataat tgctgactac acgaataggt gaacgcccgc aacggaggag 1336201 aaaggacagc acagggtcgt ttttcctgcc ttccatcaca tcttcaacgt actgaacagc 1336261 gctgatctcg tgtgcgtatt tataatacaa aggaatgcgg ccgccgccga gaaggcgttc 1336321 cagtctttta tcaacagtca gctcatacat cgtattcatc agccattttc cgattccaag 1336381 ctttcgataa tgaggagaaa cagaaatatc cactacatat aaagtatttc catgaggttc 1336441 atgattttta atcgatccgt tgtcagttgc ttgtgcccat gtatgatcag gagaatcagg 1336501 ctcaaattgt acaataagag cagtcatgga accgataatt ctgccattga tgagcgcgca 1336561 taaagcgcct tccggaaagg ttttgatatg gctggcaagc tggtcctctg accacagcaa 1336621 ttcctgggga aacggaggag ggaaacattc ttcttgaaga gaaatcagcc tctcgatgtc 1336681 agtctcagtg tagtttctaa tggtcagagc ctcaaatttt ctgccgtcat gcacatacat 1336741 ttgttttagt atgatcatca ctctccttat gttgtttcat tataacgaag attgaatttt 1336801 cagtaaatat attccgattt tcttataatt tattttttga ttattcattt ttcaaacgaa 1336861 agggccgata tagaaattag gaggggattg gtttgtttaa aaaacttcac atgaagattg 1336921 ctgtttttgt ttcgattatg ttaatcatca cagttgttct cttaatgctg tcttcttatt 1336981 tgacgctaaa accgatgatt acagaggatg ggaaaaatac aactcaaaac gtgacgcagt 1337041 cacttgaaca aaatattgaa ttgcaattaa agagttatgc catttcgtta tcaagattgg 1337101 ctaatgggga attaacgcat acatttgtaa cgaaaccaag taaagaagct tctcggctgt 1337161 ttcacgatga cattaagcaa atcaaagaca acgatgatta tgttgcgatg gcttacatag 1337221 gcaccgcaaa aaaagaaatg tttacatatc caaaagcgga tttcgctgag gattacgatc 1337281 caacatcaag accatggtat aagcttgcag ctgaaacccc ggatcaagtt gtttggacgg 1337341 aaccttataa agatgtcgtg acaggagaca tgattgttac tgcatcgaaa gcgatcttag 1337401 acaggcaaaa agtgataggg gttgccagct atgacttgaa actctctgct atccagagta 1337461 tggtcaataa acaaaaggtg ccttacaaag gatttgcctt tttagctgat gcgagcggca 1337521 atcttttagc ccatccgtca aatcaaggaa aaaatatatc aaaggatcaa acactgcaaa 1337581 ccatcgcatc cgagaaaaaa gggatacaag atgtgaatgg gaaaatggtt gtgtaccaaa 1337641 cgattggcga gacaggctgg aaggtcggaa cgcaatttga taccgatcaa ttaatgtgga 1337701 tttcagataa aatgaatcgg gccaatcttt ggatatcatt gattgcgctt atcataacaa 1337761 ttattctcag ctacttcctg gccaaaacga taaccggtcc gatacagcag ctgatcgtaa 1337821 aaacgaaagc tgtttccgca ggcgatttaa cagtgcgcgc ggaatcaaaa tctaaggatg 1337881 aagtcggtat tttaacaaga gatttcaatc tgatggttga aaatatgaag gaaatggttg 1337941 agcaagtgag actctcttca gggaaagtat ctgacacctc tgaacaacta acggctgtgg 1338001 ctgccgaaac taatgaaaca agcggacaaa ttgcaaaagc gattgaagaa gtagccgcag 1338061 gggcatcgga acaggcttct gaagttgaaa ccattaatga aaaatcggaa agcctgtcaa 1338121 cgaaaatcag gcaaatcgct gaggaggcag gcggaattaa agaacgctca aaatcgtccg 1338181 aggatgcaag ctataaagga cttgacgcgc tcggccagct gctgatgaaa tcaaacgaag 1338241 ccaatatgga aacgaaaaag gttgaaacga tgctgctgga tttggaaaat caaactaaga 1338301 atattgaaga agtcgttaca gcgatttcaa acatatctga tcaaaccaac ttgcttgcct 1338361 taaatgccag tattgaggca gccagagccg gagaaagcgg gcgcggtttt gccgtcgtag 1338421 ccgatgaagt gcggaagtta gctgagcaat cagccctttc tacaaagcat atcagcgaga 1338481 ctgtgaagct tatccagctt gagacaaaag aggcctctca cgcgatggtt gaggcaagca 1338541 gaatgaatga tgaacaaaac agtgcaattc acgaaactgg agaggtatta aatacgataa 1338601 ctgcagaaat gcagtcactg gtacaaggta ttgatcacat ttacgcggaa attcaaagaa 1338661 tgagtgaaga acagcttgcg atttctgaag ccattcaaag catttcagcc atatcacagg 1338721 aatcagctgc cgcagcagag gaagtgaacg catcaaccga tgaacagctt gtcacccttg 1338781 ataaagtcaa acactcaacg gaaacactaa aacatgcaag ccaagagctt atgaacacaa 1338841 ttgcaaaatt cacattgtaa tccaattaca tccccaaaca tcatttgttt tggggatttt 1338901 ttattttata agatgaatag atatggtagt ctagaaaatg aaggaaaaat gataaatttt 1338961 aactaaaatc taaacgaaac atctgggagg aatgaccttg aaaaaaacaa ttggttttat 1339021 cggtcttgga gtaatgggaa aaagcatggc atcacatatt ctcaatgacg gccatcctgt 1339081 attggtgtac acccggacaa aagaaaaagc agaaagcata cttcaaaaag gcgcgatctg 1339141 gaaagatacg gtcaaagatc tttcgaaaga agcggatgtt atcatcacaa tggtcggcta 1339201 tcccagtgat gttgaagaag tgtatttcgg aagcaatgga attattgaaa acgcaaaaga 1339261 aggtgcatat cttattgata tgacgacatc taagccttcg cttgcgaaga agattgctga 1339321 agcggccaaa gaaaaagcat tgttcgcttt agacgctcct gtttccggtg gagacatcgg 1339381 tgcacaaaac ggaacactcg cgattatggt cggtggagaa aaagaagctt ttgaagcctg 1339441 catgccgatt ttctctttaa tgggagagaa tattcagtat caaggaccgg ctggaagcgg 1339501 acagcatacc aagatgtgca atcagattgc aattgcagcc ggtatgatcg gtgttgctga 1339561 agcgatggct tatgcccaaa aatcaggcct agagccggaa aatgttctga aaagcatcac 1339621 aacgggcgca gccggaagct ggtcattgtc aaatcttgct ccccgtatgc tgcaaggcaa 1339681 ctttgaaccg ggattttatg tgaagcattt tattaaggat atgggaattg cactagagga 1339741 agcagaatta atgggggaag aaatgccagg cttgtcgctc gcaaaatctt tatatgacaa 1339801 gctagctgct caaggtgaag aaaacagcgg aacacagagt atatataagc tttgggtgaa 1339861 ataaaaaaag attgcctgta cgaaacaggc aatctttttt tattattttc cgatgaattg 1339921 ttgtgtccag atgcttccag actcaacgta accaacaccg atgtgagtaa agttagggtt 1339981 tagaatgttt tttctgtgtc cttcactgtt catccaagct tttactactt cttctggtgt 1340041 cttttggccc ttcgcaatgt tttcacctgc tgttttgtag ctgattccga aagatttcat 1340101 catatcaaac ggtgagccgt atgttgggct ttggtgatca aagtagtttt tgtctttcat 1340161 atcctgagat tttgcgcgtg cagatttgct taacgtttca tcaatttgaa gcggttttaa 1340221 gccttgtttt tgtctttctg catttgtaag ttcaacaact tttttctcat atgcacttac 1340281 agatgaaggt gcagacgttg ttgtgtttgt tttttcagca gttgcgggtg ctttagaagc 1340341 agtgttttga tcagcagctg ctttttcagt agtcttttgt gcaggttttg ccgtttctgt 1340401 cttttgaaca tcctgaactt tcacgttaga ttgcttcgca tgtttttgaa gaagctgctt 1340461 catctctttt tcgtttgcag cgtttaacgt tttgatattt gtgttaatat gcagtttttt 1340521 cactgcatcg ttaagtgaca tgttttgtac tgtgttcccc gtttttactg taaccacagg 1340581 ctggcaggag agttctttcg ctgatgcttg ctgtacgccc ccgaatgtga ataatccaac 1340641 cgcagcggca gcagataaaa taaatgcttt cttcattagt tcgtaacctc ctagagttgt 1340701 ttgtttctac agaaaaatca taacatagct tttttgtcat aaagattcca gcactttcct 1340761 ttgacaaata gagattgtca ttttcgtaaa gtaaatccgt tgaatcacta agaataaggg 1340821 aatcagcggt atatatgatt ttatcgtacc gttacatagc ttcctttttt ttgaaccgtt 1340881 agttatattt taatgtgttt ttatattgac agcttttttt actccttttc gctgtaacaa 1340941 ctattacaaa ggtgttacaa ttaatctcag tatatgtaaa tatattgaat gatttgagag 1341001 gggtaaccag aagtgactga aataggacgt gaaccaaaga aaaagagcaa aggaaacaga 1341061 gcaatcagaa tgaacctttt tttcctagct gtctttgttc tattcactgc attaattttt 1341121 aagctcgggg ttgttcaaat tgttgaaggc gaacagcatg aagaagacgc tgagaaatca 1341181 aatgcaaaaa cagcttacta tcctgcgcct cgcgggaaga tgtacgacag aaaccagaaa 1341241 gttgctgtcg acaaccagag cgttccagaa attgtgtatg tatcaacatc tagcacaaaa 1341301 acagaagata aaatcaaaac agcgaagcgg cttgcttctt tcattcatat tgataccgaa 1341361 tttttgaagg aaagggatct tcgtgattac tggatcgcag ctcatccgaa aaaagccgcc 1341421 gctctgctta aggaatcaga aagcaatctg aaaggagacc aggcttacaa gcttcaaata 1341481 gagcgtgttc cggatcaaga attaaaggct attcagcaag atgacgaaga aatggaaact 1341541 gctgcgatat atacaaggtt ttcaagcgga aatgcttacg aacctcaaat cgtaaaggca 1341601 atgaatccaa ataagagcaa tagcaatgga aaaaacggag cgctgcttga tgagaagaaa 1341661 aactcctcgc aaagaccaaa aaatgactta acatatgatg aaatttccat tgtttctgag 1341721 catttagaag aacttccggg aatcgatatc gtaaacgatt ggacacgaaa atatccttat 1341781 gacaaaaccc tttattctgt tttcgggggc gtcacgacac ctgatcaggg cctgctgagc 1341841 gaccggaaag atttctactt aacaagaggc tatgcgaata atgacagggt gggaaaaagt 1341901 tatttagagt atcaatatga agaatattta aattcgcata aagaaaaagt ggaatacgta 1341961 gaagataata aaggaaatgt cgtcagccaa aaaaccattg ataagggcag caggggatac 1342021 gatcttcagc tttcttttga catggagctt caggcaaagg tagaaaagat cattgaagaa 1342081 gaagtaagaa acagccgtgc acgcggaaat tacatgcttg acagagcctt tgccgtaatg 1342141 atggacccga ataacggcga tattttatca atggcaggga aaaagataga tttaaaaacc 1342201 aacaaaattg aagattatgc gataggggca tttaccaccc aatatgaaat gggatcagca 1342261 gtaaaggggg ccaccgtgct agccggctat caggacggga tcccgcatta taaatattat 1342321 atcgatgctc caatgctttt aggaacgaat cttataaaaa aatcttatac taatatggga 1342381 accatcaatg aattaaccgc attgcaaaaa agttcaaacg tatatatgtt caatgttgcc 1342441 atgcatattg caggcgtaac atacaagccg catggatctc tcccggctga tcagaacgat 1342501 ctactgaaaa tgagaaacta ttacagccag tttggtctgg gagtaaagac aggtattgat 1342561 ctcccgcagg aatcagccgg aatgcaaacc acacctaaaa ctgtaggagg attaatttta 1342621 gacttagcaa ttggccaata cgatacatac acaccgcttc aaatggctca atacatctca 1342681 gtaatcgcca atggtggcta tcgtgttcag cctagaatcg tcacaagtat tcataagcca 1342741 ggaaaaaaag accagctggg taaggcgatt gaacatagga aacctaaagt actcaataag 1342801 attaataatt cagagagcga tttgaaacaa gtacaaacag gcatgaaatt agtcacttct 1342861 tcagggacag caaaaaatac gtttacagaa gatgtatcag ggaaaacggg aacagcggaa 1342921 acattttact acggcacgaa tcgcaactgg tgggggaaaa aaacatacaa tctgactttt 1342981 gtcggctatt acccgtcgaa aaaaccaaaa gtggccttta gtgttgttgt tccatcagta 1343041 gatgatgatg ataagatcaa taaaattatt gccaaaagag ctatccacgc ctacgcagag 1343101 ctcgaaaaaa aacacagtaa aaaataaaaa acagggtgca caactaaaag attgtgtgcc 1343161 ctttctttta ttcaaaaatt gacgttcacc ataagaatag aaggagaata ctcattttct 1343221 agcgaatcat actaggtaaa agtcaatctg tatatgtcga aacacgatga tcatgcaaag 1343281 gagggattct gtggaacagg atacgcagca tgttaaacca cttcaaacaa aaaccgatat 1343341 tcatgcagtc ttggcctcta atggacgcat catttatata tctgccaact ccaaactgca 1343401 tttgggctat ctccaaggag agatgatcgg atcattcctc aaaacgtttc tgcatgagga 1343461 agaccaattt ttggttgaaa gctattttta taatgaacat catctgatgc cgtgcacctt 1343521 tcgttttatt aaaaaagatc atacgattgt gtgggtggag gctgcggtag aaattgttac 1343581 gacaagagct gagcggacag aacgggaaat cattttgaaa atgaaggttc ttgaagaaga 1343641 aacaggccat caatccctaa actgcgaaaa acatgaaatc gaacctgcaa gcccggaatc 1343701 gactacatat ataacggatg attatgaacg gttggttgaa aatctcccga gtccgctatg 1343761 catcagtgtc aaaggcaaga tcgtctatgt aaacagcgcg atgctttcaa tgctgggagc 1343821 caaaagcaag gatgctatta ttggtaaatc gtcctatgaa tttattgaag aagaatatca 1343881 tgatatcgtg aaaaacagga ttatacgaat gcaaaaagga atggaagtcg gaatgattga 1343941 acagacgtgg aaaaggcttg atggcacacc tgttcattta gaagtgaaag catccccgac 1344001 cgtctacaaa aaccagcagg ctgagctgct gctgctgatc gatatctctt caaggaaaaa 1344061 attccaaacc atcctgcaaa aaagccgtga acgatatcag ctgctgattc aaaattccat 1344121 tgataccatt gcggtgattc acaatggaaa atgggtattt atgaatgaat cgggaatttc 1344181 cctgtttgaa gcggctacat atgaggattt aattggcaaa aacatatacg atcagctgca 1344241 tccttgcgat cacgaggatg taaaagagag aatccaaaac attgccgagc aaaaaacaga 1344301 atctgaaatt gtcaagcaat cctggttcac ctttcagaac agggtcatct atacggagat 1344361 ggtctgcatt ccgacgacct tttttggtga agcggccgtc caggtcattc ttcgggacat 1344421 ctcagagaga aaacaaacag aagaattgat gctgaaatcg gaaaaattat caatcgcagg 1344481 gcagctcgcg gcgggaatcg cccatgagat ccgcaaccct cttacagcga tcaaaggatt 1344541 tttacagctg atgaaaccga caatggaagg caacgaacat tactttgata ttgtgttttc 1344601 tgaactcagc cgtatcgaat taatactcag tgaactgctc atgctggcga aacctcagca 1344661 aaatgctgtc aaagaatatt tgaacttgaa aaaattaatt ggtgaggttt cagccctgtt 1344721 agaaacgcag gcgaatttaa atggcatttt tatcagaaca agttatgaaa aagacagcat 1344781 ttatataaac ggggatcaaa accaattaaa gcaggtattc attaatttaa tcaaaaatgc 1344841 agttgaatca atgcctgatg ggggaacagt agacattatc ataaccgaag atgagcattc 1344901 tgttcatgtt actgtcaaag acgaagggga aggtatacct gaaaaggtac taaaccggat 1344961 tggagagcca tttttaacaa caaaagaaaa aggtacgggg cttggattaa tggtgacatt 1345021 taatatcatt gaaaaccatc agggagttat acatgtggac agccatcctg aaaaaggcac 1345081 agcgtttaaa atttcatttc caaaaaaata aaaacaacgg cttaaacgcc gttgtttatc 1345141 gtctgcattg cttcacgttt ttttaataca aataattcta aacggtctag gccttctctc 1345201 agcgtgtcca ttgagcatgc aaaagacagc cttacatatc cttcaccata tgttgagaac 1345261 gagctgcccg gcacgagtgc cacgccagcg tcttccaaaa gagccatact aaaatcaaat 1345321 gaagtcattc caaatgattt aatagaaggg aagatataaa acgcaccgga cggtttaact 1345381 acgtcaagtc ccatggaaac aagacggtca taaacatagt ccagacgttt tttgtattgt 1345441 tctctcataa tcaatgcatc gtcaaagccg tttgtgacag cttcaagcgc ggctttttga 1345501 gaaatggatg aggcgcacga cacattgtat tgatgaacct ttaaaatgtg ctttgcaatg 1345561 tctttcggtg caaataaaaa tccaattctc caaccggtca tgctgtgtga ttttgacaac 1345621 ccgttaatga caatcgtttg atcccgcaaa taggttgcga tggagtaatg cggtctgtca 1345681 tatgttaatt cactgtatat ttcatcagac aatacgaaga catttctgcc ttttaagaga 1345741 gctgcgatgc ttttcagttc ttcttcagat aaagtcacgc cggtagggtt tgacggataa 1345801 ggaagcacga cacacttggt gttgggtgtc agagcatctt caatcagccg ggcggtaagc 1345861 ttaaagccgt gtgacgtagt atcaacaatg acaggcttgg ccccgcacaa attgataata 1345921 ggttcatagc ccggataaat aggccctggc ataatgactt catcaccggg agataaaatc 1345981 gtccggaatg cagcatcaat ggcttggctt gcgcctgttg tgatgataat ttcagattca 1346041 gcatcatagt tgaaatccgc ttttttcttc atataaagct gcacagcttg tctcagctcc 1346101 aggtagccgg cattcggagt atatgacgtc acgttttcat caatggcttt ttttgcggca 1346161 gctttcacat gatgcggtgt gaaaaaatca ggctggccga ttgtaagtga aatgacgtct 1346221 tcgtgttggg ctacaagatt cgagaatttg cgtattcctg aaatttcgat ctctcttgct 1346281 ttcggattca gcaaatgttc cataattcat caccttaaca aatataatga gtttatccta 1346341 ttttaccact agctgatcat ttgtcacctt tttaactgat atatttcgat tgtatgcgcc 1346401 ttttttctaa acataccttt cttttcagaa aaaaagaaga caaccagcga tttgattgtc 1346461 tttattgtat catgttctat tattgtttat atgtgccaat ttcattaata gccataatca 1346521 aaatgaaggt cttcgtgcca aatcagatac ggaggatgct cttcttgaag gtcagctgat 1346581 tctttcttca tattcaggta agtttcttca ctgatatcct ctaaaacagt catttcgttt 1346641 tctttaaata ttactaaggt acccattatt tacacccttc tttggaaaaa tccttgacta 1346701 ttttatcact gttagttgga aagtcaatgg ttattaggaa aaaagtttct tttttgagga 1346761 acgcggcttg ttgccttcgg aattcgattt tgaagagctg ccattcactt tttacaaatt 1346821 acgccgatat atacagtaca atactgaatg cgaatagcga gggattgaat tgtcgttaca 1346881 acaatacgaa attttattgg attctggtac aaatgaatta gaaattgtga agtttggcgt 1346941 gggtgaaaat gctttcggaa ttaacgtcat gaaggtaaga gaaattattc agcctgtcga 1347001 ggtgacatca gtgcctcact cccatcagca tgtagaagga atgattaaac tcagaggaga 1347061 aatcctccct gtgatcagtc tcttctcatt ttttggagta gagcctgaag gatcaaaaga 1347121 tgagaaatat atcgtgactg aatttaataa acggaaaatt gtttttcatg tcggctctgt 1347181 ttctcaaatt cacagagtat cctgggaagc gattgaaaag ccgacatcgt taaatcaagg 1347241 aatggagcgg caccttaccg gtattattaa gctcgaagac ctgatgatct ttttgcctga 1347301 ctatgaaaaa attatttatg acattgaatc agattcaggt gttgacacgt ataatatgca 1347361 taccgagggc ttcgatgaaa gaagaactga taaaaagctt atcattgtag aggactcacc 1347421 gcttttgatg cgcctcttgc aggatgaatt aaaagaagca gggtacaaca atatcgcttc 1347481 gtttgaaaat ggaaaagagg catatgaata cattatgaac cttgctgaaa acgaaactga 1347541 tttatcaaaa cagattgata tgatcatcac tgatattgaa atgccaaaaa tggacggaca 1347601 caggctcaca aagctgctga aggaaaatcc gaaaagctca gatgtgccgg ttatgatttt 1347661 ctcatcgtta attacggatg atctgcgtca ccgcggcgaa gttgtaggcg cagatgagca 1347721 aatcagcaag cctgagatca gtgatttgat taaaaaagtg gatacgtatg ttattgaata 1347781 aataaaaaca gccgttgcca gaaagaggca cggctgtttt tattttaaaa gtaactctcg 1347841 ccaagttttt taaagaccgg tttatggtaa gctggctgct ggcgatttgg cactagcggc 1347901 ttttctttca tgccgacata ttcttgcaat aggtgtttcg cttttgttaa agacatttga 1347961 gctttaggat ttcgatacga ttgattaagt gtacctaaat gcggaagatg ttcgaagtct 1348021 tctttagttg gaggcatgtg aaaatagtag tctccgattg agataagcac gtccgattgc 1348081 tgttggctga accttggatt ttttgaaaaa tgaagcccta ttttctttcc tttaccttct 1348141 ttgacaagct tttgcaaagc ccgttttttc agcagatata ggtatttagg gttgggggcg 1348201 gtttttgcat ggcggttcac agtgtaaact gcttttgaaa gattttctac ggttggctgc 1348261 agatctttcg tatatgcatg gtcgtccatt atttctctcc tttgctctta tcaatttcta 1348321 tatgtttaga ttatactttt ttaaagttga aatgcaaata ttgaatgtaa aaatgcgctt 1348381 ttttctaaga aaaaaagcgc atttttaacc tgcattatac agatcttgcc ttctttttcg 1348441 gctgttcttg aaatgcttcc tgaacattca cttccacagc ctgagcactg tattttggca 1348501 gtgcaataaa ataaaaaata aaaacgagca ggataataac acccatgccg taataaagat 1348561 aatcaatgtt tgaaacaaac ttagggaata acagcgcgac taagccgagt gtcaaagatt 1348621 gtgcaaacat cataaaaggg tcctgcatgc cgcttacacg tcccatcagt tttggatgaa 1348681 caatttttgg catccaccct ccgattgcaa tgttgatcgg tccgatacac attcccagtg 1348741 caaaagctgc cgcgtaatac acccataaaa tattggtgta gccgaggacg aagatcagca 1348801 aacctgcaat gaaaatcggt atcgacatta aaaagtgcgg cttcactttt ttagagatga 1348861 gcgtgccgat tacgcttcct gccagaagcc caaacccgag tgcgatcgta aatacagacg 1348921 tatgccactc ataacggtca ggcgccaatc catatttcat tgtaaacatc ggcaatacgg 1348981 cgaatcctcc attgacaaat ccaaaaatga agaagccaaa aataagagat gccagcaatt 1349041 tgttttttaa aatatagagg atgccttctc taaagtcatt tattgaatcc ttaacagaag 1349101 tctttctcca gctgaatgca ccgtttggct gtcgggcttc ttttggaatc cggcagctgc 1349161 ggatcagcag cccggaaatg ataaagctga caaaatcaag aataatggcg ccttcaatac 1349221 cgattgtgtt gtacataaac gcgcctatgc cgactccaaa caccataaaa atgctaaaaa 1349281 gcatctgatt aagccctgcc gctttcgcat aatgctcctt cggcagaatg gcttgtacca 1349341 aactgttttc tgccggaaag aaaaactttg ttacagcgct tctgataaat aagatacaaa 1349401 aaacaagagg aatattgccg gtaaataaag tgaaaaaaag cacgacagtc aggcctgctc 1349461 tgatccaatc acaattttct gccacctttt ttctatcaaa ccggtccgcg acgactccca 1349521 cgatcagaaa tacaaatatg gtcggaagag aatacatcag ctccgccaag gtcgtatatg 1349581 aaggctggct gctgaatcgg tccagcaaaa aaaaagcaaa ggccatgttg cctactgtcg 1349641 tgcccatttg agaagcgagt gctgcgaaaa atagacgaac aaaattacga tttttaaata 1349701 tatccataaa aacgctcctt accctaaagg tcccacttta tcatattata aaccgcctgt 1349761 ttttgaaaca aataagaaaa cattaccggt taatcgtgac tctcgttccg tttggcacaa 1349821 ttgaagcaag ttcgatcacg tctttgttat gcatgcgaat gcagccttta gaaacagcct 1349881 taccaatcga agcgggatta ttcgtcccat gtattccgta gtgctgcttt gaaaggctca 1349941 gccaataagc gccaaatggg ccgccgggat tgcgctggcg gttaataatg taaaactcgc 1350001 cagtaggcgt ttgcgttagt attttaccaa cggcgatggg ataggttttc attacccgat 1350061 tatttaggga cagcgtaagg gtcttcgctc cgattgagac tgcgatatga tacggaattg 1350121 tataagggtc cggcagtccg gggatgacta tggactgtcc cgcggtgagc cctgcctgca 1350181 gtgacggatt agcctggagt aatgcagccg tgctgattct gaaatcagcc gcgatgctgt 1350241 tcagtgtatc accttgcttc acctggtacg taagcagttt cctcatcctc cttttttact 1350301 tataagtatt gatgaggagc ccatcctgct acattaattt gtgcttttta aggtgaagac 1350361 agtgatttca ggcttggcaa gaaaccgcaa aggcagcctg gtcatcccga ggcctcggtt 1350421 tacgtaaata tgagtgctgc ccgtttgata cattccctct gtgtagactt ttccatatgg 1350481 aggcgtaata atcggtccgt aaaaaggcag ctgaatctgg ccgccgtgtg tatggccgga 1350541 aagctgaagg ttcacgggat aatctgttgt tttcaaggct gcatcaggtt catggacgag 1350601 aagaatggaa aaaagtctgt cgctcagcct tgaaagggtg ccttcataat ctgggtttcc 1350661 cagcattaag tcatcaagcg aagcaatctc gattttgctg ccatctgcga gtgacaatgt 1350721 ttgatagcca ttgcgatata ccgtgaaacc tccggccgtc atcaggcttt tgtaaacggc 1350781 agttccatag cctccgtgat catgattgcc gtaaatacaa agcttgccga agggagcatt 1350841 aagctttctc aataatggaa tgactgcctg gtggtgctgg tacgtatcag gattatcaat 1350901 aatatcacct gtaaaaacaa tgagatcagg tttagattca ttaattgtaa gaatgacagt 1350961 ttttaaatct tcgagagtaa agtaatcact caagtgtgca tcgctgaact gcacgatttt 1351021 aaaaccgtca aatccgtgcg ggatgagaga gctttttatt gtgtgttcgg ttgtctcgat 1351081 catatgcggc tcgagatacc tggcatagcc atatcccccg ccggccgtta aagccccggc 1351141 agcaagagcg ccgaacattc cttttagaaa ttgtcttctg gacatctttt tcatttcaaa 1351201 ccaaccttta atagagtttt tctattatat catctgtatc tgataaaaat ctcatatgag 1351261 catgtgctga cagaggcagg gatataatga tagaatatta ttgaatgaat aatcattcac 1351321 aattggaggg ataaacatgg aaaaaaaggc ggtaattatt accggcgggt caagcggcat 1351381 gggaaaagcg atggcaaaaa aacaggctga attagggtgg cacgttatgg tgacagggag 1351441 gaaccatgag gcacttgagg aaacaaaaaa agaaattcag acctttgagg gacaggtcgc 1351501 ttgttttcaa atggatgtcc gttccgattc cgccgcttca gacatgatta aagaagcggt 1351561 aaaagccttt ggccggcttg acgcgctgat taacaacgcg gccggaaact ttatttgtcc 1351621 ggcagaaaag ctgacgccca atggatggaa agccgttatt gagattgttt taaacggcac 1351681 atttttttgc agccaagcag cggcaaggca ttggattgac cagaagcagc agggtgtcat 1351741 tttaaatatg gcagccacgt acgcttgggg agcgggagcg ggggtcgttc attccgctgc 1351801 agccaaagcg ggggtattgt cattgacaag aacgctggcc gttgaatggg ggagcaaata 1351861 cggcattcgt acaaacgcga tagcccccgg accgattgaa cgaacaggcg gtgcggagaa 1351921 gctatttgaa tcggaaaaag cgatggcccg cacgatgaac agtgtgccgc tcggccgatt 1351981 gggcacaccg gaggaaatcg ccgctttggc agcgtttttg ctttctgatg aagcatccta 1352041 tataaacggg gattgtatca caatggacgg ggggcaatgg ctgaatcctt atccgtttta 1352101 atctgaatat ttataagtga atatttaagt tattaagaac ttttatgttc gaatgtaata 1352161 cctccacaat taaccttctt cctatccaat ttgataacac atagagcttt atttgtttat 1352221 gaggtgttgt gtcatacgta agccacctaa tatatgaaag gtatatttta aaaggggaga 1352281 cgaaatatga agaacttaga tttcaaataa aacattcata taattacttc gttaactaaa 1352341 aagagaaatt ataagaatga aaggtttcaa ggttacatca gattgggagg aaggtaatat 1352401 aatggacgag atggtattat taactcagga atggctcaat gaaacgtaca aaggaaaaag 1352461 tggctacaat tccattgagg aaaatgggaa aactggctgg aaaacaatgt atgcattaac 1352521 tagagcatta caactagaat tgggaattac acagacttcc gacagttttg gtcctacaac 1352581 tttaagaaag cttaaagaat taggcccgat ttctacgtca actaattcaa aaaaaaatat 1352641 tgtgaaaatt attcaaggtg ctctttattg taaaggttat ggtccaggtg gattaacggg 1352701 tacatttggt cagggaacga aagaggcgat agcagaaatg caattgcata tggggctttc 1352761 taaaacagac ggtgtagtaa cgcctaaggt gtttaaagct ttattaaaca tggactctta 1352821 tatcctttta aatggggcgt cagagaaagt tcgttcaata cagcaatggc taaataataa 1352881 atattacaat agagagaatt tctactttat gccctgtgat ggcctgtatt caagggatac 1352941 tcaaaagtct cttgtttatg caatacagta cgaggaaggg ttaagtgata gtatagctaa 1353001 tgggaatttt ggaccaacta ctcaaagatt gattcctgta ttaagaattg gagaaacaga 1353061 tgaaaaaaac agttttattc atttatttca agctgctcta atctttaatg gctacaatgt 1353121 tccttttgat ggagtatact ctgaatctgt aagatcaaaa gtaaaggctt ttcagtcttt 1353181 tgcaaaatta caacagagtg gtactgccga ctttcaaaca tgggcttcac ttctagtaag 1353241 tactggagac cccaatcgaa aaggagttgc ttgtgactca attactcaaa ttacatcgga 1353301 cagggcggag tcccttaaga gggcaggtta taagattgta gggcggtatc taacaaatgc 1353361 gccggggagt acactaaata aaaaaataca accaggtgaa ttagaaacta tcttaaaatc 1353421 aggtttaaat gtttttccga tttatcaaac ctatggggga gcaacaaatt attttaataa 1353481 agaacaagga aagaaagatg cgtttgctgc ttataaagca gcaaaagaat acgggtttaa 1353541 aaataacact gtaatatact ttgcagtaga ttatgatgca tatggtaacg atttaaacaa 1353601 caatattatt ccacacttcg aaggtataaa tgaaataatg aacggttttt taggttcaac 1353661 ttacaaaatt ggtatttatg cccctaggaa tgtatgtact atagtttcta aaaaaggttt 1353721 agcatttgca agttttgtaa gtggtatgtc tactggcttt agcggaaact taggatatcc 1353781 tttgccttac aattgggcgt ttgaccaaat ttcaacaatt actgttggaa atggttctgg 1353841 aatgattgaa attgataatg atatttgttc aggtttggat aatggagtta ataccataaa 1353901 tatagtgcct tcagagaata agaagttttt tgatcaaatt gatgttttat atgaaactgc 1353961 tgaaaaatat gctcaaatgc aaagcgactt aaataatggg gtaaaaaaaa cacaattagc 1354021 taatgagttg gttgcccagt atttaagaaa ggatgactac aaagggtgga agtgggtccc 1354081 taccgcaggc cagattgatc ctatttatcg tgaatgggca gtaaagcgct aggggaagac 1354141 ctagtaaatg gaattgttga tcctatatca aaaactgtca taggaacgca gcatcttatg 1354201 gcaacttata atgccattat ttatagtggt ggttactctc aaacactacg agattttgct 1354261 ggttggactg gagatctatt aacaacaata caggacatga aattacacgc tcaagaattt 1354321 aattcgcctt atgatgcggc tatgaaaata ataggtaata tgtatcaatt tagcctagat 1354381 gatttattta gtgatgtaga tgcaattaat ctagcgaata aaacatcagt tggtgctaat 1354441 gcacaacctc taaatatcgc aattagagat tattatagta ataatgactg tatgaatagg 1354501 ttcactcaat ttgtaaataa tagatttgat ggttcgttag acaaaatttt ctctgaagca 1354561 gagtattatt taaatacaaa ccttgaccca gttgttgttc caattaggtt agcctttaaa 1354621 cgtgcttttg atgttgagga ttatagtgaa gagattggaa aaataacagc acaagcattt 1354681 agagatgtta tcgagaaaaa aatgatatct gaataaactg caaaacaagc gaacgttaaa 1354741 actggtcgtt cgcttgtttt attttctatt taaatttatg atataatttt taaagattaa 1354801 ggagtgattc attgaagaaa ttgttaaaaa agttagttgt attattttta agcagtttag 1354861 ttatcatctt taatgtttgg tactttatta tttgtgcttt ttccccagag tattatcaaa 1354921 atacaaatct tacttctaat gaaataataa gatttgaaaa actataccac atagattttc 1354981 ctgatgaaac aaaatttatt aaagctagag agtatttggc tgggcccgga ggagatacgt 1355041 cagctgtatt atatgtgtct ctgccaacca agcgggtaga aaaagtttta tctgattaca 1355101 cgtatatgaa aataaactat actgacaatg tcggttcaat gtatggagtt gacgtttcaa 1355161 agagtgtcgc cggtttaaca actcttacat ttggcactta cgataaaaaa ggaactttct 1355221 ataatatgaa acatgatgat gattggatgt ataaaggcac tgactggaat ctttactttt 1355281 ggacagctgc tagttataat gctgttattt ttgtatttgt tttggttatt gtgaaacaaa 1355341 tgaataaaat tcttaattaa ccagtatgta gattgataat ctcaaaaaaa ttttcctctt 1355401 cttttaacat actccatacg acctactttt ccatactatg atttttttga aatttgtggt 1355461 gtagttataa ttgtgcgtat aatcagacaa agatagagaa gcaggtgata acatgttgga 1355521 tccacttgat attttaacga acattgatga tgtccttcca tattaccagg cgatttttag 1355581 tgccgaggag cagaaggttg tcggatatga ggtgcttgga cgaattttgg cagattcaga 1355641 aatccaaagt ctcgggccct tctttttaga tgcggggata cccgaagaat ataaattaga 1355701 ggttgataac agaattatcc gccaggctct tgaccgcttt ttagaggcgg attctgatct 1355761 gctgattttt atgaatcagg atgccaatct gctgatgctg gatcatggtg aaagctttct 1355821 ggagcttctg aaagaatatg aagcgaaggg aatcgaactc caccgttttg tgcttgaaat 1355881 tacagagcac aattttgaag gggatattga gcagctctac catatgcttg catactatcg 1355941 tacatacgga attaaaatcg cagttgacaa catcggaaaa gaaagcagca acttggacag 1356001 aatcgcgctg ctctcaccag atctgttaaa aatcgatttg caggcgctga aagtgtcaca 1356061 gccgtcaccg tcatatgagc atgtgctgta cagcatatct ttattagcaa gaaaaatcgg 1356121 tgcggcgctg ctgtatgaag acattgaggc gaacttccag cttcagtacg cctggagaaa 1356181 cggaggccgc tattttcagg gctattactt agtgtctcca tctgaaacgt ttctagagag 1356241 agatgtattg aaacaaagac ttaaaactga atttcaccaa tttatcacac atgagaaaaa 1356301 gaaactggag accgtctatg agcactctga acagttttac aaacgagtgc atcaggctgt 1356361 gacctctttg agaaaaaaca atctgtcttc tgatgatgac tttattaaaa agctggcgga 1356421 agagctgaca gattgcagct tcaggattta catgtgtgat gaagaaggcg atcagctgac 1356481 gggaaatgtg tttaagcaag atggagaatg gatttatcag ccggaatatg cggaaaagaa 1356541 ctggagctgg cgcccttatt ttctggagaa cattatgaga atgagaaatc tcagaaaagg 1356601 ttttttcagt gatctgtaca gtgatttgga aacaggtgaa atgatcagaa cgttttcata 1356661 tccgatggat gatcagatgt atttatttat agacttgcct tattcttatt tatatgagca 1356721 ggacggactg atttaacggc tgaaaggccg ttttttttat gaaatgaaaa aaatatcaaa 1356781 aaacgattga cattgatact gagaatcatt atcatttaat tatagagaga agctactctc 1356841 tgttccccaa cccctctatc agatcaagat ccgaaaaaac ttggcgctac ccccgccaag 1356901 ttttttattt gtcaaagcat aggacaatcc aatgaaacaa taaacctaac tagtggtaaa 1356961 cgtttaacac ggggagaaac attgagtgcc gaacacccct gacactgctg cacgggtgag 1357021 gaggaaaatt cgttctgaaa tgattatttc agttccgttg tttacctcta tccagcatga 1357081 ctcccattga ttatggccac gcgggacttc accataaaat tcaaaagaag gttttgacaa 1357141 agttgcaaaa aggcattctt aatgctgcca aagattcgaa aaaaattata attatgtgca 1357201 tgacattcaa aaaaagcctc aaactaaaga aaaatagttt ttttcacttt ttttctttgc 1357261 ttaaattcag cagtgaaaat gccatcctgt ccgactttat ggtatgatgc tcaatagaac 1357321 ttgtattata ataaatactt gttgatttga agttgctttt tgaaaggagt ctttttttag 1357381 aatgtcacaa ttaatgggta tcatcacacg gctgcaaagt ctgcaagaaa cagcggaagc 1357441 ggctaacgag ccaatgcagc gttatttcga agtgaatggt gagaaaatat gcagtgttaa 1357501 atatttcgaa aaaaatcaaa cgtttgaact gacggttttc caaaagggtg aaaaacctaa 1357561 cacatatccg tttgataata tcgacatggt ttccatcgaa atctttgaac ttcttcagta 1357621 agattcctga aataggggga acaagcttcc gcctttgcaa aagtaatcga aataaacggt 1357681 aaggaacata cttgtttcat ggttgtaaat ccttgaaaag gagtgtcgtg atggctgatt 1357741 cttttctgtt ttataatctt tcagaagcac agatgacctt tcaagatgtg atggaacggc 1357801 ttaaagcctt tgttcaaaag gacccccgtt cttcttatgt gttatcgatc ggaaccgatt 1357861 cacaggttta ccgcgattac acaaagttta ttaccgcatt gcatttgcat cgtacaggca 1357921 agggagcttg gggctgcttg aaaaatcata cagtcgacag acccatacat agccttcggg 1357981 agaagatttc gttagaaacg gcgtacagcc aagaaacggc cgctcatatt cttgatggac 1358041 acttaatgga tattaccgat ctgctcctgc cctttaccgg tgagggggcg gatcttacct 1358101 ttgaagttca cttggatatt gggaaaaaag ggcttacaaa agatctgatc caagaaatga 1358161 ctggacgtat tacctccatg gggattgagg ccaaaataaa gccggattca tacactgcct 1358221 tcagctatgc aaatcgtttc acaaaataat ttggctgaaa aagccaaggt aaatgtcgaa 1358281 ttatgcggtt gacgtttgtt atctgattac ttattctagc ggtagagctg aaagtaagtt 1358341 gtcttgcttt cagaggtatt cagtataaaa cagggggcct gattgcgaat gagtcttatc 1358401 ggtgaacgat ttacagaaga agaacaaaaa cttctgctga atatcctgat caaccatgag 1358461 tatgccatcg agctattaag cagtgagatc aacgatatag agacagggac caaaaacgtt 1358521 gacggaacca cctacaaaaa acttgtaacg ctatacgacc gatttcgatt tgaaaattaa 1358581 tgggacaccc tataattgat actccacaaa gagtatcttt tttattgaaa ggaaactttt 1358641 cgacaaatac tgataaagtt tatattattg caatataggg aatgtattga tgatgaaaat 1358701 gaaaaggggt cgaaaacatg ataagcttac aatcagatca acttcttgag gcaacagtcg 1358761 gacaatttat gattgaggcg gacaaagtag cgcacgtgca agtcggaaat aaccttgagc 1358821 atgcattatt agtattgaca aaaaccggat acacagccat cccggttctg gatccttcct 1358881 accgtttaca tggcttaatc gggacaaata tgatcatgaa cagtattttt ggacttgagc 1358941 gaattgagtt tgaaaagctt gaccaaatca ctgttgagga agtcatgctg accgacattc 1359001 cgcgccttca tatcaatgat ccgattatga agggattcgg catggtcatt aataacggat 1359061 ttgtctgtgt tgaaaatgac gagcaggtat ttgaagggat ttttacgaga agagtcgttt 1359121 taaaggaatt gaataagcat atacgctcat tgaataagta ggctgtacgg tcctattttt 1359181 attatatagg cagagtgaaa aaagaaagcg catacataat ttaaacgaga atagggcttg 1359241 aataagaaac taagatttta ttagaatggg agataagaaa aacttattga taacaaaaag 1359301 gaggacgaca tgcagcttca agagcttcat atgctcgtag ttttagctga ggaattaaat 1359361 atgagaaagg cggcagaacg gctttttgta tctcagccgg ctttatctca gcgcttacaa 1359421 accattgaaa aggcgtgggg aacaaaaatc tttttaagat ctcaaaaagg attaacggta 1359481 acgcccgccg gtgagaaaat cattcagttt gcgaatgatg tgacattaga gcaggaaaga 1359541 ataagagaaa atattgacga gcttgaaggt gaaattcacg gcacattgaa gcttgccgtc 1359601 gcctccataa tcggtcagca ttggctccct aaagtcctga agacgtatgt ggaaaagtat 1359661 ccgaatgcaa agatctcgct cataaccggg tggagcagcg aaatgctgaa aagcttgtat 1359721 gaggatcagg ttcatatcgg cattataaga ggcaaccctg agtggaaggg gcgcaaagat 1359781 tacttaatga cagatcatct gtatttagtg gatactgaaa tttcctgcat cgaagatatt 1359841 gcccatacag aacgtccgtt tatccagttt aaaagtgaca gcacttattt tcaggaaatt 1359901 cagcactggt ggcatcaaaa atttaaaacg tcgccgaaac agacgatatt ggttgatcag 1359961 attgaaacgt gcaaacagat ggcgctgcac ggaatcggtt atgccatttt gccgtctgtt 1360021 acccttcaaa atgaagataa agtgaataaa atgcctcttt tagacatgaa agggcatccg 1360081 atcggtcggg atacatggtt attaggttat gagcctgcct ttgaactgaa acaagttcaa 1360141 gcttttgtac aagtgataaa ggatatgctg gatcaggaaa atccatttta aagacagcga 1360201 ggtgctgtct tttttttatt tatctgttga caatgaaaat cattatcatt taaagtgata 1360261 catatgatat tgaaaatcat tatcaactaa tggggtgata acatggctaa agccttgatt 1360321 acatatgcca gcatgtcagg aaatacagaa gacattgcct tcataataaa agatacgctt 1360381 caggaatatg agttggatat cgattgtgtc gagataaatg atatggatgc gtcttgttta 1360441 acctcctatg attatgtact gattggcacc tatacatggg gggacggcga tttgccctac 1360501 gaagcggagg attttttcga agaggtcaaa cagattcagc ttaatggttt aaaaacagcc 1360561 tgcttcgggt ctggcgatta ttcttatcca aagttttgcg aagcggtgaa tttgttcaat 1360621 gtcatgctgc aagaggcggg agctgctgtt taccaggaaa cactaaaaat tgaattagcg 1360681 cctgaaacag atgaagatgt ggaaagctgc cgagcgtttg cgagaggttt tcttgcatgg 1360741 gcagattata tgaacaagga aaaaatccat gtttcataaa ggggcaaccg ctgttacggc 1360801 atcggcgttt tctggatatt ttgtggcggt acaaagagaa ggcatttttc attactcttt 1360861 ggagcagggc tggagaaagc tttttcgttt gaaaagtaag atacactgta tcagctacat 1360921 agggccttac ttatttggcg ttggtgaaaa gggaacagtc attcgttcgg ctgatgaagg 1360981 gaaaacctgg acgatgtcga gctttccgac aaatgcaaca gtgtgggcga ttaccggcag 1361041 aaacaacggg tttgtctgcg cccacggtaa gcattgtatt tatgtatcgg atgattttgg 1361101 tgtctcatgg cgcgtagcca aaccttttgc cgaatttcat aatccccctg ttatccggtc 1361161 gttatgcctt cacgggggca atctctttat cggcacgcaa atacacgaat attttggcgg 1361221 catttgggct tacgacatta agcgtgacac tgtccaagtt gtcaaaaaag aaaaaaaccg 1361281 gatgacggca tccatgctcg tgttcaatga aaattggctg gtggcggcga tgggttctgt 1361341 gaaaggaaag cacggtgctg tcactgtaag gaatcttttg aatggtgaag aattcaccat 1361401 acaatccagt atgatcagaa atgaagaatc atttcttgat ctttcagagg atgatggcat 1361461 tatatatgtc actacaacac aagatgaaaa tggtttttcg agaatttacc aggttgatct 1361521 cgaagcccgg tcgttaaaat ggttcgatac cattaaggga catggatgga gagtggccaa 1361581 tcagaaagag aatttctttt gcgcaggctt gtatgaatgt aaatttgtcc agccgtacga 1361641 agtttcagca atgattcatt agaggaggaa caaggaattg gcgaagattt tgctcgttta 1361701 tgcaacaatg tcaggcaaca ctgaagctat ggcagatttg attgaaaagg ggcttcagga 1361761 ggcgttagca gaagtagacc gtttcgaagc aatggatatt gatgatgccc agctgtttac 1361821 cgattatgac catgtcataa tgggaaccta cacgtgggga gacggagatc tgcctgatga 1361881 atttttagat cttgttgaag acatggagga gattgatttt tccggcaaaa catgcgctgt 1361941 attcggttcc ggtgatacag catatgaatt tttctgcgga gcggttgata cgctagaggc 1362001 aaaaataaaa gaacgcggtg gagacattgt gctgccttcg gtaaaaatcg aaaataatcc 1362061 agaaggtgaa gaagaggaag aattaataaa cttcgggaga caattcgcaa agaaaagcgg 1362121 gtgcgctgtc tgatcactca ctgggaactg ctaaaacggc tgttcctttt tttcttgtct 1362181 ttgtatcttt cctttgatac agtaatgagg tagaaaatca ggaggaggac tatacatatg 1362241 aaaatgatgg acgcaaatga aattatttca tttattcaaa atagtacaaa atctacacct 1362301 gtaaaggttt acgtgaaagg tgagctggaa ggaatcaatt tcggtgaatc tgcgaaagct 1362361 tttatcaatg gaaacactgg tgtcgttttc ggtgaatgga gcgaaatcca aacagcaatc 1362421 gaagaaaacc aaagcaaaat cgaagactat gtggttgaaa atgaccgccg caattctgcg 1362481 atcccaatgc ttgatcttaa aaacatcaaa gcgcgtatcg agccgggtgc gatcatccgc 1362541 gaccaagttg aaatcggtga taacgcagtc atcatgatgg gtgcttctat taatatcggt 1362601 tcagtcatcg gcgaaggcac aatgattgat atgaacgttg tgcttggcgg acgagctact 1362661 gttggaaaaa actgccatat cggcgcgggt tctgtacttg cgggcgttat tgagccgcca 1362721 tccgctaaac cggttgtgat tgaagacgac gtcgtaatcg gcgcaaatgc tgttgtgctt 1362781 gaaggtgtaa cagtaggtaa aggagctgtt gttgctgcgg gagcgatcgt ggtaaacgac 1362841 gttgagccat acactgtcgt tgcaggcaca ccagctaaaa aaatcaaaga cattgatgaa 1362901 aaaacaaaag gcaaaactga aatcaagcag gaattacgcc agctgtaagg aaaagtttga 1362961 taaaaaaggc gtggataata tatccacgcc ttattcgtat aggcaggagg aatagaaatg 1363021 aagatagagg agctcatcgc aattcgcaga gatctgcatc gtataccgga gcttggattt 1363081 caggagttca aaacccagca gtatttatta aatgtcttgg aacaatatcc gcaagacaga 1363141 attgaaattg agaaatggcg aacagggctt tttgtaaaag tgaacgggac ggcgccggaa 1363201 aaaatgctgg catacagagc ggatatcgat gcgctttcta tagaagagca aactggtctt 1363261 ccattcgcat cagagcatca cggcaacatg cacgcctgcg gtcacgattt gcatatgaca 1363321 attgcactcg gcattattga tcattttgtt caccacccag tcaaacatga tttgcttttt 1363381 ctgtttcagc cggcagagga agggcctggc ggtgcggaac caatgcttga gagcgatgta 1363441 ttaaaaaaat ggcagcctga tttcatcact gcccttcata ttgctccaga gcttccggta 1363501 ggcaccattg cgacaaaaag cggccttcta tttgcgaata catcagagct agtcatcgat 1363561 ctggaaggca aagggggaca tgcggcatat ccgcatttgg ctgaggatat ggttgtagca 1363621 gcaagtacac ttgtcaccca gctgcaaacg attatctcta gaaacacaga tccgctagac 1363681 agtgctgtta ttacagttgg taccattacc ggaggctcgg cacaaaatat cattgcagaa 1363741 acggcccacc tggaaggcac gatccgcacg ctttctgaag aatcgatgaa acaagtaaag 1363801 gaacggattg aagatgtagt gaaaggaatc gaaatcggat tccgctgcaa aggaaaagtg 1363861 acatatccgt ctgtatatca ccaagtttac aatacgagcg gattaacaga agaatttatg 1363921 tcttttgttg ctgaacatca actggcgaca gtaattgaag caaaagaagc aatgactgga 1363981 gaggattttg gctatatgct gaaaaaatat cccggattca tgttctggct cggcgctgat 1364041 tctgaacatg ggcttcatca tgctaagctg aatcccgatg aaaatgcgat agaaacagcg 1364101 gttcatgtca tgacaggtta tttttctgtt tatgccaatt aagtacaaat gaaagaataa 1364161 aattccataa aatgagcact ctagtaaacg gaggtgttca aaaatggcta aaaaaattgg 1364221 aattgaacaa tcgttatcag atgtagaagc tgctttaaaa gaaaaaggat atgacgttgt 1364281 aatgatgaaa agccctgctg atgctcaagg ctgtgactgc tgtgtcgtaa caggtcttga 1364341 taataatgtg caagggatag ccgatacggt aacacaagca cctgtcatta cagcttccgg 1364401 gatgacggct gaagaaattt gtagcgaagt tgagagcaga attcagtaat aaaaaaaccg 1364461 aagcaaaaag cttcggttct tttatttatt ctgtttcttt agggaaagcg cggtcgaacg 1364521 cgttctttat ttcttttctc aacactcgtt cgactcgcca ctgttccata ttttctgttt 1364581 tggcaatgac cctgattaca atttcagaag tccccagttc ttgaatcccg atgacatttg 1364641 ggccttcttt tatttgtgga agagccgctg ccgtttcatc acaaacctgc tgtaaaatat 1364701 gaatcatttc atcaatattt ctttcagccg gcactttaat gtcaacaaga gcctgcatgg 1364761 taccacgaga atgattgctc acgtttgtga tgtttctgtt ggggatgtaa tgcagtgttc 1364821 cgtcaaagct gcggatttga gttgtcctta agccaacctg ctcgacaatt ccgtcaaagg 1364881 tggaaacggt aatataatct ccgacatcca attgtttctc aagcaaaata aaaaaacctg 1364941 tcacgatatc actgacaagc ccttgggcgc caaatccgac agccaggccg acgattcctg 1365001 cccccgctaa aagagcgctt ggatcataat gaaacaaatc tagaaccatg acgaaaaata 1365061 tgaaaatcaa tgtataagca aatatgttaa gagtcaggct tcggagcgta tgtgcacgtc 1365121 cgatagacaa gctattctgc tcctcgaatt ttgcaaacag atgtttaatg attttcatgc 1365181 ctaatgatcg aacgataaaa tagagcaata tcataatggc gagtttaatg agcagaacac 1365241 cggcatttgt aatcagtccc gcccaatcat attgtttaat aaagtccatg ttgagctcct 1365301 tttctaattg attgctgcac attgagacta gttaccctgt acatgaccat gttaaacgtt 1365361 ttattcaaaa atgtcgaagc caaagacata catgatttgt taaaaattga ctcaggaaat 1365421 ctgcttttat ataatggcat tgcaatataa ctaaaaatgg ttaatcaccc tttattttca 1365481 tgcgattttg acctttaagc caaacaataa attggaggga tacatatggc agaacgtatg 1365541 gtaggtaaac aagctcctcg ttttgaaatg gaagcagtcc ttgcaagcaa agaattcggc 1365601 aaagtaagtc ttgaggaaaa catgaaaaac gacaaatgga cagtgctgtt cttctatcca 1365661 atggacttca cttttgtttg tccgacagaa attacagcaa tgtctgaccg ctatgacgag 1365721 ttcgaagatc ttgatgcaga agtcatcggg gtttcaactg ataccatcca tactcattta 1365781 gcttggatca atacagaccg caaagaaaac ggtcttggcc agctgaaata cccgcttgct 1365841 gctgatacaa accatgaggt atcccgggaa tatggcgttt taatcgaaga agaaggtgtg 1365901 gctttgcgcg gattgtttat tattaatcct gaaggggagc ttcaatatca aactgttttc 1365961 cataacaaca ttgggcgtga tgttgatgaa acgcttcgtg ttctccaggc gctgcaaact 1366021 ggcggactct gtccggctaa ctggaaacca ggccaaaaaa cactttaatt ctttccaaga 1366081 acgaaaagcg gtctagcata ttcgttaggc ctctctttta aaataggagg gaaaaagcaa 1366141 tgaaattacg tcagcccatg ccggaattga cgggagaaaa agcttggtta aatggtgaag 1366201 tgacgagaga gcaattgatt ggggaaaagc cgacgcttat tcatttctgg tccatcagct 1366261 gccacttgtg caaagaagcg atgccgcaag tgaatgaatt tcgtgataaa tatcaagatc 1366321 agctgaatgt tgtagctgta cacatgcccc gttccgaaga tgatcttgac cctggtaaaa 1366381 ttaaagaaac agctgctgaa cacgatatca ctcagccgat ttttgttgac agtgaccatg 1366441 ctttaaccga tgcatttgaa aatgaatatg tacctgcata ttatgtgttt gataaaacag 1366501 gacagctccg tcacttccaa gccggcggga gcggtatgaa aatgcttgaa aaacgtgtga 1366561 accgcgttct ggctgaaacg gaataggtat ctgactaaat agtatttcct aaaaacctga 1366621 cctcatcagg ttttttattt gtgcaaaaag caatggaaga agagtaagaa gcttattttt 1366681 ccaaatttgg gtataggaat tgatgatttg tttgattgat acgctaaaaa acacagctaa 1366741 tttttgatgt ttttcctcaa ttttagataa atctcatatc tcataactcg aaaattgtag 1366801 atattacact aaatttcttt aaagaagtaa gtaaaatata tattttcaac attataccaa 1366861 ataaactaga aagcccctta atcccttgag aataaaggac tcttttgaaa aataaaacat 1366921 tttcagaaaa taaggaattt ttcatagagt aaatataata gtaaaatgct aaaataatag 1366981 ttgataaaat tacttttgta atctaatatc ttaattaaag atgttaattt tgataggggg 1367041 tacattgagg aatgtttaat gaaagagaag ctttgcgctt gcggttagaa caattaaatg 1367101 aagctgaagt gaaagtcatt cgtgaatatc aaattgaacg tgataaaata tacgcaaaat 1367161 taagagagct ggacagaaat ggaagccctt ccgaaatcaa aaaggatttc cgttctgaaa 1367221 aaaaacctga ctctctgccg gttctcgctg agcttgcggc tcaggaaatc agaagctatc 1367281 agccgcaatc acagcagcag tctgttcagc ctcagcttca atctatttcc tctcttcctg 1367341 ccggtatacc agacggaaca acacgaagaa gaagaggaac ggcaagaccg ggatcaaaag 1367401 cagctaagct gcgtgaagct gctattaaaa cattaaaacg ccacaacgcg gcgattaaga 1367461 gctcggagct tcaaaaagag attgaaaaag aaagcggtct tgaaatccct aatatgacaa 1367521 cgtttatgca aagcttaatt aaaatgtacc cggaagtgaa aaagccatat cgcgggcagt 1367581 acattttaga gggtgaaatc gaatctgcag aatcagcaaa cgaataaata taaagaaaaa 1367641 ctgcttggca tcgctcaagc agttttttta ttgaggtttt ttctgtgaag gtttgttttc 1367701 tttttcaaga ttaagcttat acacccactt ttgataaggc ttttcttcag cggctctgtt 1367761 tttcagctct tcgattgtat ggctcttggc ctggtctgat gattgggcgt gggcaagctg 1367821 tttttgaagc acatgtatct gtttggtgac atcttcaagg atagtctcta catgatttgg 1367881 ctgcgcgtag gccgctggag cttcttcttc cgttttttct ttttgtttcg tgccgccatc 1367941 aatatcggca aaatgagaag caatccaggc atcgctttca tcaagttgcc gtttatacga 1368001 tataatagtt tcgtgaaata atttttcttt cgttttttct atgtctagca gtctttcttt 1368061 cgtttctatg attcgatctt tcatatgatc aacttctatt ttaatatgtt ttagctgata 1368121 ttctttttct accatttgct cttttagacg cccgttttcg gcttttatca attcggcttg 1368181 ctgttttgcc tgaagcagtg cattttgttc ctgctcaatt gaggcttgaa gttcgctgat 1368241 ccgtttatga agatttttat tttcttcttc gattttgact ttcgcaatat gaagtttatg 1368301 tttttcttcg atttcggctc tgcgtttata ggtttcagca gatagaagct cctgcaaaac 1368361 aacgatttta tcaagcagtt cagctcttat ttggtgcagg gtttggctgg tgtgggaggc 1368421 atgtttttct tttgttgaca tatgtgttaa ttcggcagac agctgctgga gtttttcttt 1368481 catatcggta ttttctttga gcagtttgtt atttttctga tgaaagtagc ttgcttcaag 1368541 ttcagaaatc agcttatggc accttgaaag ctcggatttt aaataaaggt tctcctgaga 1368601 cacgtcgtgg aaaaaaggac ctgatctttt cattcgaacc atctccctca tgatgttaac 1368661 actacaatat gcaaatactg aacagctatt cctctttaat aaacagacaa gcagtagcgt 1368721 tgagcctttg cttttgctat gcttttaacg aaactagagg tgagatgata tgaagcatgt 1368781 aaacgtactg ctggcagggg gagcctcacg tcgctttgga gaaccgaagg cgtttgtcaa 1368841 atggaagggc aggatgcttt acgaatgcgc taaagaggca cttggagaac aaacggttat 1368901 catcagccgt cccgaattta ttgatagatt tcaagaaaac ggtgaaaatg aagtgtatca 1368961 agatgctgag ccatttcaag gcatggggcc attggctggt atatataccg cttttaaaaa 1369021 gacagacggt gatctttata ctgttctttc ctgtgacaca ccgctgatac aaagaaggac 1369081 gatgctggag ctcaaacgtc tgatgattgc cggtgcggac gcggtagtcc caatttcaga 1369141 cggacaagtg cagccattga ttgcgattta ccacaaacgt atcatgccag ttctatacga 1369201 tcagctttct gagaagaggt tgagaatatc agatttatta ggcagaattt cggtttgtta 1369261 cgtacaggct gaaaatatcg gagcaaaccc ggcagagttt atcaacatta atacacgtga 1369321 tgattttagc tgtttggaag aaaaatcgaa ctccctcaag cgggactgac ggggcaataa 1369381 catgataaga tgacataaaa gataaggaga acaggtttga tggaggaacg ttattcacgg 1369441 caaatcagat ttaagcaaat tggggaagag ggccagaaaa gactggcaga cagccatgtg 1369501 ctgattgtcg gagcgggagc gctcggcact gcaggagctg aagggctttc gagagcggga 1369561 gtcggtacga ttaccattat tgaccgtgac tatgtggagt ggagcaatct tcaaaggcag 1369621 cagctttata cagaaagcga tgccaaactc cgcatgccga aagccatggc tgccaaagag 1369681 catctatcag cgattaacag cgagatacat attgaggcgt atgttaccga aggaacagcc 1369741 gaaacgcttg agccgctgat tgaaaaagca gatgtcgtga tcgacgcgac agataatttt 1369801 gaaacccgca tgctgataaa cgatcttgcc cagaaaacaa agacaccttg ggtctatggc 1369861 gcctgtgtaa gcagccaggg aatgttcatg actgtcattc ccggagaaac cccttgtctg 1369921 tcttgtttgt ttgagcaaat tcctgtcggc ggggcgacgt gtgatactgc cggcattatt 1369981 ccgcctgctg tgcatatcgt ttcagcatat cagcaggctg aggcattaaa gctgttaacc 1370041 ggccaaaaag aagcaataca gcgggggttt gtgacatttg atgtctggaa caattcgcat 1370101 atgaagatta acgttaatca tgtacgccgt gaggaatgcc catcttgcgg agctaatgcg 1370161 gtatatcctt atcttcagga ttggaacaca ccaaaagctg ctgtactatg cggccgtgat 1370221 acagtgcagg taaggtcaga atcattaaaa agaatcccga aacaggagct cattaagcgg 1370281 ctgaaaacaa tcggcaaggt cgaggctaat gcgtttttgc tgcatatttt ttacgaggat 1370341 ttcagaattg tcattttcaa tgacggacgg gcactggtgc atggaacaaa tgatgtgaaa 1370401 gaagccaact ccgtgttggc aagagtgatt ggactgtaac aacaggaggg gtcagaatgc 1370461 tggagaaaag aacaccgata ccggtagacg aggcagttcg gcgtgtctgc cattttcaaa 1370521 aacaaggtga aacagaatgg gtggcgcttg aagacagcct tcatcggttt ttagccgaag 1370581 atataactgc ggatcaccac gtacctgcgt ttgaccgttc gccatacgat ggttttgctg 1370641 tcagagcgtg cgatacggca gaagcttcac gtgaaaaccc agttcggttt gaagttattg 1370701 accatattgg agcgggagca gtatctgaaa aagaacttgg cccgtttcag gccgtgcgga 1370761 ttatgactgg cgcgcaaatc cctgaagggg cagatgcagt cgtcatgatt gaactgactc 1370821 aagcctttga ggagaatggg aagtcattta tgtctttaaa acgccgcttt cagacggggg 1370881 ataatatttc aaaaacaggt gaggacgctc aaaaagggag tgttttactg acaaagggca 1370941 cccgggtgac accaggagtg acggctcttt tggcaacatt cggatacgca tctgtgcctg 1371001 tcgtgagaaa gcctgtagtc gggattatcg caaccggtac cgaattgctg aatgtcagtg 1371061 atccgctgga accgggaaaa atccgcaaca gcaatgcgag tatggtatat gcgcaagcga 1371121 tagaagcagg cgcaacaccg ctttatttag ggaaaatctc tgatgaactg gataaaagct 1371181 ttgctgcagt taaagaagcg atgaaaaagg tggacttcct gatcacaact ggcggtgtgt 1371241 cagtcggtga ctttgacttt ttgcctgcga tctatgaaaa actcggagcg gacgtgctgt 1371301 ttaataaagt tgccatgcgc ccgggcagcg tgacaacggt ggcgcatgca aacgatatgc 1371361 tgctgtttgg cctttcaggt aatccgtcgg catgctatgt cggttttgaa ctgtttgtca 1371421 aaccgataat ccagacatgg ctgctcaatg aaacaccgca ttcaatttgt gcggaagctg 1371481 ttttgaccaa ggattttccg aagccgaacc catttacccg atttgttcgt gcgctcgtgc 1371541 accatcagga agggaagctg ttggcgacac ccgttggctt agataagtcg agctctgtca 1371601 catcacttgc agatgccaat gcatttatta tcctgccggg cggtacgcga ggctacgaat 1371661 ctggcagaac ggttcaagtg ctgctcatca gagaagagaa tggaagtgaa tggccttggt 1371721 ccgtcctttc ccgatcgtcc aagttgtagg atttcaaaac agcgggaaaa caacgtttat 1371781 tgagcgcatt cttgaaaaag cctctgaaca gggagtccat ttgggctgcc tgaagcacca 1371841 tggtcacggc ggtgaaccgc aaacgctcac ggaaggaaaa gacacggacc gttacaaggc 1371901 ggcaggtgct gatgtaacag cggtagaagg tgctggtgtg ttacagctga ctgcccgccg 1371961 caattgggat ttggcacggc tgattgagtt ataccaattt ctcgaaacag actgtcttct 1372021 gattgaaggc tttaaaaaag ccccttatcc taaagtggtt atcctaagtg aaaaggaaga 1372081 tctggaagcg ctgcaagcag taaatataat cgccatcatc tatagaaaaa aagagcatat 1372141 gacagagcat cagggattac ccgtttttca tgcggatgat ccggttgccg tggattttgt 1372201 gctttcacag ctgaaggggg aatctgcata atggaacggt ttgagattac gaaaacaccc 1372261 attaatactg aaaacatcat caaaaaagtg gagaaacggg aagcgggagc cattacaaca 1372321 tttattggta cggttcggga atggacaaac ggaaaaagaa cggttcggct tgaatatgag 1372381 gcatatgaac cgatggccgt gcaaatgctt gctcaaatcg gcgctgaaat cgaagaaaaa 1372441 tgggaaggtg cctcagctgc gatcacgcac cgtataggtg tgctcgatat cggtgaagca 1372501 gcggtagtga ttgctgtatc ttctccccat cgaaaagccg catatgaagc caatgagtat 1372561 gcgattgaac gcattaaaca gattgtgccg atttggaaaa aagaaatttg ggaagacggt 1372621 gagcaatgga tcggcgacca gctagaaacg acagcttatc cgaacggaaa accagaccta 1372681 agcgagggag agcagcatga ttaaaattct tttatttgca gggcttgctg aacaggccgg 1372741 tacacaagca atagaaatag atatggaaca agcaaccaca gatgaaataa aagcgagtct 1372801 aaaagaacaa tacggtcttg aatctattga tacggctatg attgccgtta acgaaagcta 1372861 tgtaaaagaa aatacctctg tatcttcggg tgacacggta gccatcatac cgccggtcag 1372921 cgggggatga aaaccggacg gcatttcagc cgtccggttt ttctgtattt cattggcata 1372981 tccccaagta tcctcagcat acaatgattt tctgtaagcg tttattctac atatgttact 1373041 ccctataaag taagagactc actccataat tagactgaaa ttttgaaaaa taatagaaat 1373101 ttatttcggg tatcgatata gtgaagatga taaatgttgg aaaggtgctg gatatggaga 1373161 catttaaaag attaaaaatg tattattggc cgtacagaaa agtgtttatg tggtcgcttc 1373221 tagccatgct tttgatgact gcaattactg tcgtttatcc gattatcctg caaattacga 1373281 ttgatgagat cgtactggga cggcagtatc agcttgcggc gtgggtcagc ttaggattta 1373341 ttgcggtgat ggttttgaaa ggaatggcta ccttttttca tcagtattta ggtgatatgt 1373401 tcgggatcaa atccgtttat cggctgagaa atggtctgta tgaaaaactg cagcggcttt 1373461 ctttttctta ctatgataac gcgaaaacag gagatttgat gtccaggctg actgctgatg 1373521 ttgaagggct tcgttttttc ttatcatacg gtctcgctga gctcattcgc ttcggcctgc 1373581 tggtagccat cagcctgtcg gttatgtttt actattctgt tcctctcacg cttgtgacaa 1373641 tagctgttct gccatttctc gcggttgcgg tataccggtt tgacaaaaga gtccatcccg 1373701 ccttcagagg catccgcaaa tcgtttgcga aactcaatac aaaagttcag gaaaatatca 1373761 gcggcattaa tacggttaaa tctctttcca gggaagattt tcagatcagc actttcaata 1373821 aagccaatgc agaatacagg gcgcagtatt tacaaacatc atccatttgg tctgcgtatt 1373881 tccctttaat ggagttcatt ggtaacactt gtattgtagc tcttctctca tacggcggtt 1373941 acttggttat gcaaaatcag ctcaatcccg gcgagcttgt tgctttcttc agccttgtca 1374001 attatatgat gtggcccatt atgaacttag gttttgtcat caatatgttc tctcaagcaa 1374061 aagcgtcagg ggaacgcctg ctcgacattc tggaaaaaga agaagacatt acagatcatc 1374121 ctcatgcttt gcataaacaa aaattaaccg gagatgtcca tttcaaaaat gtttctcttg 1374181 catacggaaa agaacaaaca aacgcgctgt gcaatgtaag ctttgaggca aacagcggga 1374241 aggtaatcgg actgttgggc ccgacaggtt caggcaaaag ctcagtgaca cagcttctca 1374301 ccagatttta cagtcctgtt ggcggaatga ttaccattga tcacaaaccc atcacagatt 1374361 attcgttaaa aacccttcgc tccaatatcg gggtcgtact tcaagaatcc ttcctgtttt 1374421 catctacgat tagatcaaat atttcgtatg ggcggccgga tgcctcaatg gaagacgtca 1374481 tcgaagcggc aaaaagggcg caggctcata actttattat ggagcttcct gatgggtatg 1374541 acaccatgct gggagagagg ggaatggggc tttccggcgg gcagaaacag cgtattgcca 1374601 ttgcgagagc catctgcttg aacccgagca ttttaatatt ggatgatgcc acaagcgcag 1374661 tagatatgca aacggagcac agcatacagc ttgccttaaa agaagtcatg aaaaaccgca 1374721 caacctttat cgtcgctcac cgcatttctt cactgaaaca cgctgatgaa attctcgttt 1374781 ttaataaagg acgcattcgt gaaaggggaa cacatcatga gcttcttgaa aaaggcggct 1374841 actataaaaa gatttacgat ttgcaatacc gtgatgtcaa aatgattaat gagccgcatg 1374901 aggtcggata gggaggggcc aaatgaaaca agcgaaaaaa cagggggttt tagagcgttt 1374961 ctattactct tcagatgaaa tcattgaaaa gccgtttaac tgggctcaaa tgtggcggct 1375021 gctgagctat gtcaaaccat atcgaaaaac aattttgccg ctttcttttc tcactgtatt 1375081 gattggcact gctgtgaagc ttgtgatccc cattttgatc ggcgtttatg ttcttgatca 1375141 agcgattaca gggagaaact cggagctgct gattcagctc atttttatta ttagcggttt 1375201 atatgtcctc aattacgccg ccaatgtgtt aagaatcagg tggatgaatc agcttggcca 1375261 gcatgtcatt tacgatttgc gacagcattt atttacccat gtgcagcgct tatcccatcg 1375321 attttttgat cagcggtcgg cgggatcgat cttagtcagg atcatgaatg atattaactc 1375381 tcttcaggag ctctttacaa gcggagtcat caatttgttg accgacttgc tgcttctggc 1375441 cggcgtgatt attattttgt ttacgctgag ccctgagctg actatagcca tcatggtgac 1375501 attgccgatt atgtttttta tttcaacaag tctcagaaaa aaaatacgcc gatcctggca 1375561 aacggtacgg ctgaagcaat cgaagctcaa ctctcatcta aacgaaagca ttcagggcat 1375621 ccgggtcacg caggcattta cgcaggaaga agaaaacatg gcgtattttg acggtgtcaa 1375681 tcaggagaac tacgaatcat ggcgggaagc aactagaaaa aatgccatgt tccgtccgct 1375741 tgtagaaatg acgaatgcga ttgggacggc tgtcttgatt tggtatggag ccacactcat 1375801 catgaatgaa accattacga ttggcgtctt cgtttctttt gctttctatc tgggaatgtt 1375861 ttgggaacct atttcgagac tgggtcaggt ctataatcag ctgttaatgg ggatggcatc 1375921 atcagaacgg atttttgagt ttctggacga acagccaaat gtcaaggaga agccgaatgc 1375981 cattcataat gaaaagataa atggggagat cagttttgaa gaggttgaat tttcgtatga 1376041 tgaaaaacga aaagcccttc acgccgtttc tttctctatt cctgcgggat cgacgcttgc 1376101 gcttgtcggg catacaggga gcgggaagac gacgattgcc aatttaatca gccgttttta 1376161 tgatgcggcc ggaggcacca ttaaaataga cggtataccg attaaggatc tttcccttgc 1376221 cagtctgcgc tctcaaatca gcattgtcct gcaagataca tttattttct ccgggaccat 1376281 catggaaaat attcgttttg gaaggccaaa tgcttcggat gaagaggtga tgaaagcgtc 1376341 ccaagcggtc ggagcggatg agtttatttc cgatttagcg gaaggatacg caacagaggt 1376401 agaggaaagg ggcagcgtac tgtctgccgg tcagcgccag ctcatttcat ttgcaagagc 1376461 attgctcgcc gatccggcta ttatcatcct tgacgaagca acggcaagca ttgatacaga 1376521 gacagaagta aaaattcagc aagcgttaaa aacgcttctg aaagggcgta cagcagtgat 1376581 gatcgctcac agattgtcta cgatccgcga cgccgaccgc atcattgttc ttgatcacgg 1376641 caggaaaata gaagaaggga accatgatca gctgctcgct aaaggaggca tttatgccgg 1376701 gcttgtgaaa gcgcaataca gcacagcgat agaataatat gaaaagcctt caatattgaa 1376761 ggtttttgga aatttattag aaaaacatga aactttttga tatccttccc gtactatttg 1376821 ttagatattc tcaaggaggt tttgaaatgg aaacgaatgt agaaaaaaac agcggaacgg 1376881 cgactgaaaa gccttcactt ttcggagtaa tcacaagtcc gtccgttcaa tttgaaagaa 1376941 taagagaaag gccggctgta tggggaccgc ttttgattgt tgcagcaatt atcatcgtcg 1377001 gtgccgtgct gcaatcactc ggtacggatt atagtgagct tttgaaaagc caggatacgc 1377061 aagggctatc tgctgaacaa atggaaactg tcgcaacaat aaccaaattt ggcggaatgg 1377121 caggcgctat tatcggcggt atcgcagcat tatttattgc ccctcttatt tattggctct 1377181 gtgtaaaagt atcaggcggt gttacgacat ataaaaaaat gctttctctc agtctgtttg 1377241 tctctttgat tagcagtctc ggattattgg ttaatggaat cgttgctttt acgactgacg 1377301 tgaatcctct ttacagcacg acgtcactcg cagggattat cccatctgac ggggctctcg 1377361 ccagtgtgtt aaataccttt gaaattttca gcatctggag ctttgtatta ttagcaatcg 1377421 gacttcacaa aacgggaggc atctcaaaaa aagccgggtg gatttcagca atcattctat 1377481 tcggaatttt agttgtattt tcgctttttt caggtttaat caattctgtg gcgggtgcat 1377541 aagctcatga aaaaagtctg gatcggaatt ggaatcgcag ttatagtcgc tctttttgtt 1377601 ggaatcaata tataccggtc tgccgctccg acaagcggca gcgccggcaa ggaggtacag 1377661 acggggagcg ttgaagaaaa tgaaatctca tcaacggtta tggttcctgg cacgctaaaa 1377721 ttttcaaatg aacagtatgt cttttatgaa gcggataaag ggacattaga agacattaaa 1377781 gtaaaggaag gcgataaagt taaaaagggc acggctttag tcacctatac aaatgagcag 1377841 ctgagcctgg aaaaagaaca gaaccagtta acgtctgaat ccaaccggct tcaaattgac 1377901 caaattcaag aaaagttaaa agccttggac agcaaagaaa gagaactgga aaaacaggta 1377961 ggaaagaaag aagcagaaaa acaaatcgaa tctgaacgga cagagcttca aatgcagaaa 1378021 aaaacagcgg agatcgaatt aaaacaaacc gagcttcagc ggcagtcact tgccaaccgg 1378081 gtgtcagatt tagaagtgaa aagcgaaatt gaaggcaccg ttatttctgt caaccaagaa 1378141 gcggcatcca aaaagtcaga tattcaagag cctgtcatac atatcggcaa cccaaaagac 1378201 cttgtcgtct cagggaaatt gtctgaatac gatacattga aagtcaaaaa aggccagaag 1378261 gtcacactca cttcagatgt aatacagggt aaaacatgga aaggcacggt ttccgcagtc 1378321 gggcttgttc cggatcagca ggagagcgct gcggcacaag gaacagaaca ggcggtccaa 1378381 tacccgcttc aagtgaaaat aaaaggaaat cttccagaag gaaagccagg ctttaaattt 1378441 atcatgaata ttgaaacaga taaacggaaa gcaaatacgc ttccttcaaa ggcagtcaaa 1378501 aaagaagatg accaatatta tgtgtataca gtaaaagacg gaaaagcaaa gcgagttgat 1378561 gtcaaaatcg gcgaagtgac agatgacctg acagaaatta aagaggggct tacccaagat 1378621 gatcaagtca ttttgaatcc atctgatcag gtgactgacg gaatggaagt gaaatcctaa 1378681 atgattcagc tttctaatgt gcgaaaaagc taccagatcg gaaaggaaac gtttgatgtt 1378741 ctccattcta ttgatttgga cattcatcaa ggtgaatatg tctcgattat ggggccgtca 1378801 ggatcaggaa aatcgacgat catgaatatt atcggctgtc ttgatcggcc gacttccggt 1378861 acatatcaat tggacggcga agacatttct tcatataaag ataaagaact ggcggcagtc 1378921 cgtaaccggt ccatcggttt tgtatttcag caatttcagc ttcttccgcg gctgaacgca 1378981 aaaaaaaatg tcgagctgcc gatgatttat tccgggatag gcaaaaagga acgtcaagag 1379041 cgggctgaga gagcattgga aaaggtcggg ttagccgatc gaatgctcca catgcccaac 1379101 gagctgtcgg gcgggcagaa gcagcgggtg gcgattgcga gggcgatcgt gaatgagccg 1379161 aaattgattt tagctgatga accgaccggc gcgctggata cgaaaacaag cgaggcgatt 1379221 atggatcagt ttacagcatt aaatgccgag ggaacgacaa tcgttctggt tactcacgag 1379281 cctgaagtag cagattgcac gaatcggatc gtcatggtgc gtgacggaaa cattgttcct 1379341 gccagctccg gacaaaggag tgtgggagaa tgagcctgtt ggaaaacatc agaatggctc 1379401 taagctctgt ccttgcccat aaaatgcgtt cgatcttaac gatgctcggc attatcattg 1379461 gtgtaggctc tgtcattgtt gtcgttgcgg taggacaggg cggcgagcaa atgctgaagc 1379521 agtcgatcag cggcccggga aatactgtgg agctgtacta tatgcctagc gacgaggagc 1379581 ttgcaagcaa cccgaatgcc gcagctgaat ctacgtttac agaaaacgat attaaaggtt 1379641 taaaaggaat agaaggcatt aaacaagtcg ttgcttcgac ttctgaaagt atgaaagcgc 1379701 gttatcacga agaagaaacc gatgctacgg ttaacggaat aaatgatgga tacatgaatg 1379761 tcaattcttt gaaaatcgaa agcggcagaa cctttaccga caatgacttt ctcgcgggga 1379821 atagagtcgg aatcatctct caaaaaatgg ctaaagagct gtttgataaa acctcccctc 1379881 taggtgaagt tgtctggatt aacggacagc ccgttgaaat tatcggcgtg ctgaaaaaag 1379941 taacaggctt gctttctttc gatttaagtg aaatgtatgt gccatttaat atgatgaaat 1380001 cctcttttgg cacaagtgat ttcagtaacg tatcattgca ggtcgaatca gcagacgaca 1380061 taaaatcggc tggaaaagaa gcggcacagc tggtaaatga caatcatggc acagaggatt 1380121 cgtatcaagt gatgaacatg gaagagattg cggccggaat tggcaaagta actgcaatta 1380181 tgacgacgat tatcggctca attgcaggta tttccctttt ggtcggcgga atcggtgtca 1380241 tgaatattat gctcgtatca gtcacagaac ggacgcggga aatcggaatc agaaaatcac 1380301 ttggtgcgac gaggggacag attctgactc agtttttaat tgaatcagtc gtattgacgc 1380361 tgattggcgg tctggtcggg attggtattg gatacggagg ggccgcgctt gtttcagcca 1380421 ttgcgggctg gccgtcactc atatcctggc aggttgtatg cgggggcgtg ctgttcagta 1380481 tgctcattgg tgttattttc ggcatgcttc ctgcaaataa agccgcaaag cttgatccca 1380541 ttgaagcgct gcgttatgag tagcctcatg caacatgcat gaggtttttt tatgtttagt 1380601 gatttctact atgaatataa aagacttttt tcattaaaat aagaagaaaa tgtcgtacaa 1380661 ttgtccttat ttttgtcgaa tttacagttt acaaacccta tagacatacg ttaatatgga 1380721 gaaacgtgaa agattttgat agttattgaa tgaatttgaa tgattttagt tgcctaaacc 1380781 gaaaatagcg tttacaatga aattgtattc aaaatgaata cgttttcatt aggaggtgaa 1380841 gcatgctaac tcctgaacgg catcaattga ttattgatca aatagaaaag catgatgtgg 1380901 taaagattca agagcttata aatctgacta atgcttctga atcaacaatc agaagagatt 1380961 tatcgaccct tgaagaacgc ggttttttaa agcgcgttca tggtggagcg gccaagcttt 1381021 ccgatatcag acttgaaccc gatatgcttg aaaaatcatc caaaaacctt cacgataaac 1381081 tgaagattgc tgaaaaagct gcttctcttt tagaagaagg ggattgcatt taccttgatg 1381141 caggcacgac gacattgcac atgattgatt ttatggataa aaccaaagat attgtcgttg 1381201 tcacaaacgg ggtaatgcat atcgatgcat taataaggaa agaaatttct ttttatctgc 1381261 ttggaggata cgtaaagcac agaacgggcg cgattattgg aggcgcttca ttggttgcca 1381321 tggaccagta cagatttgac aagagttttc tggggacaaa cggtgtccat acagaggctg 1381381 gatttacaac gccggaccct gatgaggccc ttttaaaaca gaaagcgatc aaacaggcaa 1381441 aacacgctta cgtcttagca gacccttcga agttcggaga aatttcattt tcggcattcg 1381501 ccggaatagg cgacgcaaca atcattacga ctgacgctga agagcttaca ttcgataatt 1381561 accaagaaaa aactgtcgta aaggtagtga aaccatgatt tacactgtaa cacttaatcc 1381621 atctgtcgat tatatagttc acgttgaaga ttttactgta ggaggcctga accgttcttc 1381681 gtatgatacc aagtatccag ggggcaaagg catcaacgta tcgagactgc tgaaaagaca 1381741 ccatgtggcg tctaaagcgc tcggattcgt cggcggattt accggagaat atatcaaaac 1381801 atttttacgg gaagaaaacc tggaaacagc tttttctgaa gtaaaagggg atacccgtat 1381861 caatgtaaag ctgaaaacgg gtgatgaaac tgaaattaac gggcagggac cgacaatttc 1381921 ggatgaagat ttcaaagcct ttttagaaca gttccaatct ttgcaagagg gagatatcgt 1381981 tgttcttgca ggaagcattc catcttcact ccctcacgat acttatgaaa aaatcgcaga 1382041 ggcctgcaaa cagcagaacg cacgagttgt tctggatatc tcaggcgagg ctcttttgaa 1382101 agcaacagaa atgaaaccat ttttgatgaa gccaaatcat catgagcttg gagaaatgtt 1382161 cggcacggcc attacatctg ttgaggaagc cgttccttat gggaaaaagc ttgtagaaca 1382221 aggcgctgaa catgtaatcg tatcaatggc cggagacgga gcgcttctgt ttacgaacga 1382281 agctgtttat tttgctaacg tgccaaaggg gaaattggta aactcagtcg gagcagggga 1382341 ttccgttgtt gcaggtttcc ttgccggaat ttccaaacag ctgccgcttg aagaagcatt 1382401 ccgcttagga gttacttcag gcagtgctac cgcgttctct gaagaacttg gaacagaaga 1382461 atttgtccag cagcttcttc ctgaagttaa ggtcacacgt ctatagagga ggaaacacaa 1382521 gtgaaaataa ctgagctttt aacgaagcat acgataaagc ttaatattga gagcaaagaa 1382581 aaagaaaatg ttattgacga aatggtcact gttcttgata aggctggaaa gttaaatgac 1382641 cgacaagcct ataaagaagc cattttaaat cgcgaaagcc aaagctccac gggtatcggt 1382701 gaaggaatcg ctatccccca tgcgaaaacg gcaagcgtta tcaacccggc gatcgcgttc 1382761 ggacgttcaa aagacggcgt cgattatgaa tcattagacg gccagccggc tcacttagtg 1382821 ttcatgatcg cggcgactga aggcgcaaac aacactcacc ttgaagcatt gtcaagactt 1382881 tcaacgctgt taatgcgtga agaaatccgt aagcagctcc ttgaagctga gtctgaagat 1382941 gccatcatcg acattattaa tcagcacgat aaagatgatg acgaagagga agaggaagaa 1383001 gaagcggcac cagcacctgc cggaaaaggg aaaattttag cggttactgc atgcccgaca 1383061 ggtattgccc atacattcat ggctgcggat gcccttaaag aaaaagcgaa agagcttggt 1383121 gtggaaatta aggtcgaaac aaatgggtca agcggcatta agcacaagct cactgcccaa 1383181 gaaatcgaag atgcacctgc aatcattgtc gcagcggaca agcaggttga aatggaacgt 1383241 tttaaaggca agcgcgtact tcaagttcct gtaacggcgg gtatcagacg tccgcaagag 1383301 cttatcgaaa aagcgatgaa tcaagatgcg ccgatttatc aaggcagcgg cggcggttca 1383361 gcagcttcaa atgatgatga agaagcgaaa ggcaagtctg gaagcggtat cggaaacacg 1383421 ttttataagc acctgatgag cggtgtcagc aacatgcttc cgttcgtagt cggcggcggt 1383481 attctcgttg cgatttcatt cttctgggga attcactctg ctgatccgaa tgatcctagc 1383541 tacaacacgt ttgcagcagc attaaacttt atcggcggcg acaatgcatt aaaactcatt 1383601 gttgcagttc tggccggttt cattgcgatg agtattgcag atcgtcctgg ttttgcgcct 1383661 ggtatggtcg gcggatttat ggcaactcaa gcgaatgctg gattcttagg cggcttaatt 1383721 gccggattcc ttgccggtta tgtcgtgatt ttactgaaaa aagtatttac gtttatccct 1383781 cagtcacttg atggattaaa acctgttttg atttacccgc tgttcggtat ttttatcact 1383841 ggcgtattaa tgcaatttgt cgtcaataca cctgtagcgg catttatgaa tttcttaaca 1383901 aactggcttg aaagccttgg tactggaaac cttgtgttaa tgggtattat cttgggcggc 1383961 atgatggcga tcgatatggg cggtccgctt aataaagcag cctttacgtt cggtatcgcc 1384021 atgatcgatg caggcaacta tgcgcctcat gcagcaatca tggccggcgg tatggttcct 1384081 ccgcttggta tcgcacttgc aacaaccatt ttcagaaaca aattcactca gcgtgaccgt 1384141 gaagctggta ttacatgcta tttcatggga gctgctttcg taacagaggg agcgatccca 1384201 tttgctgcgg ctgatccgct tcgcgtcata ccagctgctg tagtcggtgc agctgttgcc 1384261 ggcggattaa ctgaattctt ccgagtaacg cttccggcgc ctcatggagg agtattcgta 1384321 gctttcatta caaaccatcc gatgctttac cttttaagta tcgtgatcgg tgctgtcgtg 1384381 atggcaatta tcctcggtat cgtcaaaaaa cctgttacag aaaaataaga aaaaaagcgt 1384441 ccttggttcg aaaggacgct ttttcttatc cggccggcag ggagcgcggt taagttatgt 1384501 attttattct tttttatgat aaagtaaaag aagagaaaca actgacatag caattgtcta 1384561 ggaggaaaca ctttgaccga ggaaaaaaat acgaatactg agaaaacggc gaagaaaaaa 1384621 accaatacgt acctggaatg gggtaaagcg attgtcatcg ctgttctgct ggctctcctg 1384681 atccgtcact ttttgtttga accgtattta gttgaaggtt catctatgta tcccacatta 1384741 catgacggag aaaggctgtt tgtgaataaa acagtcaact atatcggcga gctgaagcgc 1384801 ggagatatcg ttattatcaa cggtgaaact tctaaaatcc attatgtaaa aagattgatc 1384861 ggaaagcctg gagaaaccgt tcaaatgaag gatgacacgc tttatataaa cggtaaaaaa 1384921 gtagccgagc cttacttgtc taaaaacaag aaggaagcag aaaaacttgg tgtcagtctg 1384981 acaggagact ttggaccggt taaggttccg aaaggcaaat actttgtcat gggagataac 1385041 cggctgaatt ctatggacag ccgaaacggg ctgggactga tcgcggaaga tcgaattgtc 1385101 ggcacatcga agtttgtctt tttcccgttt aacgaaatgc gtcaaacaaa ataaaaacgc 1385161 cttgctggcc taggacagca ggcgttttta ttttgaaaaa gaagcgacca atgcaatgca 1385221 taaaaccgtg atgaacactg aaccgataat agccagcaca ctgaagaaaa ggtgaacctg 1385281 tttgttctct tttccgcgct tttctaatag ccgtttagaa aaaatgtgcg aaaatatgta 1385341 aataagggct atgcctatat ataagccgat atctttggcg gtaaagcctg ttacggcaag 1385401 gtaaaagccc gtaaaaaaga tcagtaagca atattcagta agtgttaaaa gcctcaacgt 1385461 gttcctccat gagagtgtgt aattttccag gcggatgcat tctctctctt taattgtaac 1385521 acagctggct ggtttgggtg tataagtgtt ttctctctgt tttatcaggg aatcatttct 1385581 cttgccctgc attcatggta tacttttatt gatgatagac atgatggagg ataataaatg 1385641 attgctgtaa ataatgtaag cttgcggttt gcggatcgca agttatttga agatgttaat 1385701 attaaattta ccccaggcaa ctgctatggg ttaattggtg caaacggtgc cggtaaatca 1385761 acgtttctaa aggtgctgtc aggcgaaatc gagcctcaga caggcgacgt gcatatgagt 1385821 cctggcgagc gtcttgccgt cttgaagcag aaccattttg agtacgaaga gtatgaagtg 1385881 ctgaaagtgg tcattatggg ccacaaacgc ctgtatgaag tcatgcagga gaaagacgct 1385941 atttacatga agcctgattt ctcagatgag gatgggattc gtgctgctga gctagaaggt 1386001 gaattcgcgg aactgaacgg ttgggaagcg gaaagtgaag ctgcgatcct gttaaaaggc 1386061 cttggtatct cagaagatct gcacacaaaa aagatggcag acctcggcgg ttcggagaag 1386121 gtaaaagttc tcttggcaca ggcattattc ggcaagccgg atgttctgct gctcgatgag 1386181 ccgacgaacc acctggacct tcaggcaatt cagtggcttg aagagtttct gattaacttt 1386241 gaaaacacag ttattgtcgt atcccatgac cgtcactttt taaataaagt atgtacgcac 1386301 attgccgacc ttgattttaa caaaattcaa atctatgtcg gaaactatga tttctggtac 1386361 gagtcaagcc agctggcgtt aaagctttct caagaagcga acaagaaaaa agaagagcag 1386421 attaaacagc ttcaagagtt tgtcgctaga ttcagcgcca atgcgtctaa atctaagcag 1386481 gctacatcaa gaaagaaact tctcgaaaaa atcacgctgg atgatattaa accgtcttcc 1386541 cgccgctatc cttatgttaa cttcacgccg gaacgggaaa tcggaaatga tgttcttcgc 1386601 gtggaaggct taacaaaaac aatcgatggc gtaaaggtgc ttgacaatgt cagctttatt 1386661 atgaatcgag aagataaaat tgctttcact ggccgaaatg aacttgctgt tactacgctg 1386721 tttaaaatca tttccgggga aatggaagct gacagcggaa cgtttaaatg gggtgttacc 1386781 acatctcaag cgtattttcc aaaagacaac agcgaatatt tcgaaggcag tgatctgaac 1386841 cttgtagact ggcttcgcca atattctccg cacgaccaaa gtgagagctt tttacgcggt 1386901 ttcttaggac gcatgctgtt ctctggagaa gaagtccaca aaaaagcaaa tgtactttcc 1386961 gggggagaaa aggtccgctg tatgctgtcg aaagcgatgc tttctggcgc caatatttta 1387021 attttggatg agccgaccaa ccatttagac ctagagtcca ttacagcgct caataacggc 1387081 ttaatcagct ttaaaggcgc tatgctgttt acttcccatg accatcagtt tgtgcagacc 1387141 attgccaaca gaattataga aattacacct aacggcatcg tcgataagca aatgagctat 1387201 gacgagttcc ttgaaaatgc tgatgtgcag aaaaaattga ctgaactata cgccgaataa 1387261 aaaagcagag atttctctgc tttttttgat acctaaatgt gaaaggagat cacaacatga 1387321 aatttttggt tgtcggagca ggtggagtag gcgggtatat tggcggacgg ctttcggaga 1387381 aaggaaatga tgtgacattt ctcgtgcgcc aaaaacgagc tgagcagctt aaaaaaaccg 1387441 ggcttgtcat ccatagtgaa aaagggaatg tatcatttca gcccgaacta atcagtgccg 1387501 gagaaacagg gcaatttgat gtcgttatca ttgcttctaa agcatactcg cttggtcaag 1387561 tgatagagga tgtcaaacca tttatccatc aagaatctgt cattatccct tttttaaatg 1387621 ggtaccgcca ctatgagcag ctatttgcgg cattttcaaa agaacaggtg ctgggcggcc 1387681 tgtgttttat agaaagtgct ttagacaaca aaggagaaat tcatcatacg agcgcatcgc 1387741 atcgttttgt atttggagaa tggaacggcg agcgtacgga gcggataaga gcgcttgaag 1387801 aggcattttc aggtgtgaag gctgaagtca tcattagcgg gcatatcgag aaggacattt 1387861 ggaaaaagta tctctttatt gcagcgcaag cggggatcac aacgttattt caacgaccgc 1387921 ttggcccaat cctcgccaca gaagccggac gtcacacggc ccaaactctt attggggaaa 1387981 tttgcactgt tttacgaaaa gaaggtgttc cggctgatcc ggctcttgag gaagagagct 1388041 ttcgtacgat gaccagcatg tcttaccata tgaagtcctc catgcttcgg gatatggaaa 1388101 acggccaaac gacagaaggc gaccacctgc atggattttt gattgaaaaa gcaaaacgtt 1388161 tatctctcgc tgcaccagta ttagaaaccg tttatgcgaa tctgcaaatg tatgaagcag 1388221 aaaaataaaa aaaggaggcg gaaaagcctc cttttattta cttaaaaagc ccaatttccg 1388281 tttctgaaga taggctctct tttcccgtct gccgtaattc cgtcaatatt catatcctta 1388341 gaaccgatca taaagtccac gtgtgtaatg ctttcattta ggccttcttt gacaagctct 1388401 tcacgagaca tctgctttcc gccttcaata ttaaaggcat aggcgcttcc gatcgccaaa 1388461 tgatttgacg cgttttcatc aaacagcgtg ttatagaaaa gaatgtttga ttgtgatata 1388521 ggcgaatcgt aaggaacaag tgccacttca cctaaatagt gagaaccttc atctgtttcc 1388581 accagttctt ttaaaatatc ctcacctttt tcagctttaa tgtcgactat acggccattt 1388641 tcaaacgtca gggtgaaatt ttcaataata tttccgccgt agcttaatgg ttttgtgctt 1388701 gataccactc cgtcaacccc gtctttttgc ggcagcgtga acacttcttc tgtcggcata 1388761 ttggccataa actcatggcc actttcattc acgcttcccg cacctgccca aacatgcttc 1388821 ctaggcagct taattgttag atcagttcct tctgcttgat aatgtaaggc agcgtaatgt 1388881 ctctcgttca aatggtcaac tttttcatga agattttggt catgattgat ccacgcctga 1388941 accgggttgt cttcatttac gcgcgtcgct ttaaaaattt cttcccacag aaggtggatc 1389001 gcttcctcct ctgatttgcc aggaaacacc ttgtgagccc agcctgctga tgccgcacct 1389061 acgacagtcc agctgacttt gtctgattga atatattgtc tgtatgtatg taatgctttg 1389121 cctgctgctt tttggaatgc cgcaatccgt ttggaatcta taccttttag caagtctggg 1389181 ttcgacgaca caacagaaat gaaagcagct ccatttttgg caagctcttc tctgcctttt 1389241 gcttcccatt caggatattc ttcaaatgct tcaaacggcg caagttcgta ttttaatttg 1389301 gcgacttcgt catcctgcca attcacggtg acgttttttg cgcccttttc atatgcgtgt 1389361 tttacaatta aacggacaaa atcccgaacg tctgttgaag catttacgac tacatactgg 1389421 cctttttgga cattaacgcc gacttctacc gccagctgtg catatgtatt taatttctgt 1389481 gaaaatgaat ccatgaatca ttcctccaag cttttttctc atcatatcaa atatgatcct 1389541 ataaaggaaa gaaggagccc aaagtgaaaa acccaaaacg acacgtcttg ggttttttca 1389601 atattatgga tgattcagtt ttacagtgcc gcctgcaggc gaatggggca tatttgccaa 1389661 agaaatgctc atgcctccaa gaataattcc gcttaaaatg gctgcgatcg ctactcttct 1389721 tcctaaatct cttagcatct gtttcctcct taacgtttct ccatttccca caatatgaag 1389781 gaagtgagga aaaaagaagc aagaaatttg ccgcgtgtga gaattttgcg ggtaaagact 1389841 atttaattgc cttttgcagc ttatcaatca cttctaaaga acggcctgtg ccgattgcta 1389901 cagattcaag cgggttttgc gccacgtgta caggcacgac aatctcttct gtgagccatt 1389961 ctttaattcc attaaggagc gcgccgccgc ctgttaaaat aacgccgcga tcaacaatat 1390021 ctccgctcaa ttcaggcgga cagtcctcaa gtgtcgctct gatggcttca agaatatgca 1390081 ggagggattc acgcattgca tcttgaattt cgttggattg aagcataatg gtttttggaa 1390141 gacctgtcac gaggtcacgt ccccgaattt ccattgcctc tggtatatgt tcaatcagag 1390201 catggccaat ttccattttt acctgctcag ctgtgcgttc gccgatcagc aaattgtatt 1390261 ttttacggac gaaagaaacg atatcctcat caagctggtc tccgccgatc ctgatagaat 1390321 ggcaggaaac aacgccaccg aaggaaataa tagcgacctc tgtcgtccct ccgccgatat 1390381 ctactaccac attggcaacc ggctcatcaa ccggtaaatc cgctccgatg gcggctgcaa 1390441 ctggctcttc gattaaatga acgtttttcg cgccgcaatt tttcaccgca tcactgatgg 1390501 cgcggcgttc tactgctgtt gagcctgatg gtgtgcaaac gactacgttc ggttttctga 1390561 acgacatgcc gatgcttttt gcggcttttt tcataatgtg ctttagcagg tcagttgtca 1390621 tatcatagtc tgcgatcacg ccatctttca tcggtctgac agcgacaatt tttcccggtg 1390681 ttttaccgat catgtttttc gcgtcagctc cgattgcaag cactgctttt gtcgtcgtat 1390741 ccactgcgac aacagatggt tcatttagga taatcccttt atttttgctg taaacaagta 1390801 tattagctgt tcctaagtca atcccgattt cagttgattg aaacatgttt tcacccaatc 1390861 tctatcctaa tttaatatga ttctacattt aaagtttctc agaaatactg cgatttttgg 1390921 gggtgtgcgt cggtaaagaa atgtttttgt aaaaaatcaa ggaactgtgt aacagaagta 1390981 atacattttt cggttttatg gaaaaaatat cttgtaattc ttatagaaag cgggaaactt 1391041 tttcaaagtt tcattcgtct acgatatatt gaggtacatc cttaaaacat tacatgagaa 1391101 aagaaacatt taaaggaaga agggttttta tgaaatcaat aggtgttgtg agaaaagtag 1391161 atgaattagg ccgcattgtc atgccgattg agttgagacg ggcattggat attgccataa 1391221 aagacagcat tgagtttttt gttgacggag ataaaattat cttgaaaaag tacaaacctc 1391281 atggcgtttg tttaatgact ggagaaatca cttcagaaaa taaagaatac ggcaacggta 1391341 aaattacgct aagccctgag ggtgcacagc tgcttctcga agaaattcaa gccgctttaa 1391401 aagaataaaa ttatgctaaa aaaggcggag tgatatcatc tccgcctttt ttgcgtgcca 1391461 atttttgatt accgccgcct aagataagac atcaagatat ttggtaatga atgatttggg 1391521 atactttaca tattttactc aattatttgt cgaagaatgg tacaataagt agagaaacac 1391581 aagcggcagg tggtcatatg agaaaatatc aagctcgtat catttccatc attttggcaa 1391641 tgatttttat aatgttttgg gattatttat tttattttat aggcaaaaac ccgattaatt 1391701 ggcctgttga tattgtgtat actgcagtca cgctggtaag tgtctggatg ttggcttatt 1391761 atattgatga gaaacagcag ctggttaaga aaatgaagga taacgaatgg aagtataaac 1391821 agctttctga agaaaaaaac cgcatcatgg ataatttgca ggaaatcgta tttcaaacga 1391881 atgcaaaagg tgaaattaca tatttaaacc aagcgtgggc atctataacc gggttttcaa 1391941 tcagtgaatg tatgggaaca atgtataacg attacttcat aaaagaaaag cacgtagccg 1392001 accacattaa cacccaaatc caaaacaaag cgtcttctgg catgtttacg gcaaaatacg 1392061 tgacaaaaaa cggcacgatt ttttggggag aagttcatta taaactttac tatgaccggg 1392121 atgaccaatt tacaggcagc ctgggtacaa tgtcagatat cactgagcgg aaagaggctg 1392181 aagatgagct cattgagatt aatgaacggc tggcgaggga atcccagaaa ctatcaatca 1392241 caagtgaact tgccgcaggt attgctcatg aggtcagaaa ccctttaaca tctgtcagcg 1392301 gtttcctcca gattatgaaa acacaatatc cggacagaaa agactatttt gacatcatct 1392361 tttcagagat taaaagaatc gatttagtgc tcagcgagct gctgctgctt gcaaaaccgc 1392421 aggcaatcac atttaaaaca caccagctta atgagatctt gaaacaagtc acgacattgc 1392481 ttgataccaa tgcaattctg tccaatatcg tcatagagaa aaatttcaaa gagacagatg 1392541 gctgtatgat taatggagac gaaaatcagc tgaagcaggt ctttatcaac atcattaaaa 1392601 acggaattga ggcaatgcca aagggcggtg tcgtaaccat ttcaactgct aaaaccgcct 1392661 ctcatgcagt gataagcgta aaggatgaag gaaacggcat gccgcaggaa aagctgaagc 1392721 agattggcaa acctttttat tcaacaaaag aaaagggcac tggactggga cttcccattt 1392781 gtttgagaat cctgaaggaa catgacgggg aattgaaaat cgaaagtgaa gctggaaaag 1392841 gcagcgtctt tcaagtggtt ttgcctttaa aatcagacag ctgagaggag aaaaataaag 1392901 tgaactcgct tctgtttgta tacgggacat taagaaagca tgaaaaaaac catcatttgc 1392961 tggcacaatc ggcatgtatc aatgagcagg cgagaacaaa gggaagtttg tttgctgcaa 1393021 aagaggggcc cacagttgtt ttcaatgatg aagatgaagg ctatatatat ggcgaagtat 1393081 atgaagcaga tgaattgtgt atacataagc tcgatcaatt ttttcaagga tatcataaac 1393141 aaacggtgtt tgtagaaacg gatgtcggga ttaaaattgc gcttatttat tttatgaaca 1393201 aagacgggtg tgccggtttt acgaaaataa gcagcggcga ctggaaagaa catcagatga 1393261 tcagcaaatc gaaaaatccc atttattatt ttgcctatgg atcatgcatg gataatgccc 1393321 gctttcaaaa agcgggagtc gatcactatt ttcaagatcc agtaggaaga gctgttttaa 1393381 aaggatacac aacccgcttc acgctaaaaa gggaagacgg ttcaagagcg gacatgttgg 1393441 aagacggagg aacaacagaa ggcgttttat accgtatccc ttattctgct ctctcctatc 1393501 tatataaaag ggagggcgtc gaatctctta cgtatcggcc ggcatttgta gacgttgaag 1393561 ctggcggaag gcactacaaa gactgtttaa cctttctcgt cctccaaaaa gaagcggaaa 1393621 ttgccccgcc tcagcactat cagattgaaa tcgaacgcgg agcggagctg tatttgtcgc 1393681 ctgagtttac tgaaaagctc aagcggcata tgaattcgct gccaaaagga taacactgta 1393741 acaaaagaat atgataaaat ttgatcaata tcatgtcata taaaggagca ccacgatgaa 1393801 aaaagaattt gcggtaattg ggctgggccg ttttggtggc agtatttgca aagcattaag 1393861 cgaagaaggc gtcgaggtta tggcaatgga tatcgatgaa gataaagtca acgagtatgc 1393921 caagattgca tctcacgcag ttatcggtga ttcgacagac gaatctgtcc tgaaaaattt 1393981 aggcctgcga aattttgacc acgttattgt agcaatcggg gaaaatattc aagcgagtat 1394041 tttaacgaca ctcattctga aagaacttgg cgtccatacg attacagtta aagcgcagaa 1394101 cgattatcac gaaaaagtgc tgtctaaaat tggtgcggat cacatcgtcc acccggaacg 1394161 cgatatggca aaacgaattg cgcataatat cgtgtccaac aatgtacttg actatttgga 1394221 gctgtctgaa gagcatagtc ttgttgaaat cgtagctaac agccgcctgg ctggaaatac 1394281 gcttctcgat ttagatattc gcgcaaaata cggtattaac atcgtagcca taaaaagggg 1394341 caaggaagtc atcgtatcac cgcttgcaac cgaagtcatc caccaagaag atatactcat 1394401 tgttattgga tcagttacag acatctcccg tttcgaaaaa agagttcttc atacaaaata 1394461 gcagccaaat aagccgtcct caaagggcgg tttttcatat tatcagaata taacaacttt 1394521 aatgaactga gcgtcaattt cttaaaattt cattgactaa gcacaggcgt tccgatagca 1394581 tattgtacca tataataaaa aaaggagggg cctatttgaa taaagaagcg ctagtcaata 1394641 ggctgaatgc ttcagccaaa agacaaaaag ctgatatcgt cattaaaaac ggaaaaatca 1394701 tggacgtata taatcaagaa tggatatatg aagatattgc gattacagat ggagttattg 1394761 taggcctcgg tgagtatgaa ggcgaaaata tcattgatgc agagggacaa atgattgttc 1394821 cgggttttat tgatggacat gtacatattg agtcgtcaat ggttacaccg attgagttcg 1394881 ctaaagcagt gttgcctcat ggcgtgacga cggttgttac agatccgcat gagatcgcga 1394941 atgtgtctgg tgaaaaaggg attgagttta tgcttgaaca agctcggcat acaccgctga 1395001 atatccattt tatgcttcct tccagtgtgc ctgccgcaag ttttgagcga tcaggcgcaa 1395061 ttctcaaagc tgccgatctc aagccttttt atgaagaaga agaagtatta gggctggctg 1395121 aagttatgga ttatgtgtcg gttcagcagg ctgaaaaaga catggttcag aaactgcttg 1395181 atgcccgtgt ggcaggaaaa aggatagacg gtcatttagc tggtttatca acagacctca 1395241 ttaacattta cagaaccgca tttgtcttaa acgaccatga agtaacatcg aaggaagaag 1395301 cccttgatcg tatcagaagg ggcatgtatg tcatgatgcg tgaaggatca gtcgccaaaa 1395361 acacgctcaa tgtgctgccg gcggtgaatg aaaagaacgc acgccggttc tttttctgta 1395421 cggatgataa gcatgtggat gatttattgt cagagggaag tgtaaaccat caggtgaaaa 1395481 tggcgattca agccggactt aatccgtttt tagcctatca gctaggaagc ctcaatgcag 1395541 ccgaatgcta cggattagat acaaagggag cgattgcccc gggttttgac gctgatttgc 1395601 tttttgtatc tgatctggaa aatgtcactg tcacaatgac gatggtaaaa gggcagactg 1395661 ttgctgaaga cagcaaagcg gtctatcagg atcatgcttc aactgcagca ccagatcagg 1395721 cactgcttga ttctgttaag cttgctgctc ctcttaacaa acaggatttt catatgccaa 1395781 tcgattcaga gcagcagatc aatgtcattc aaatcatacc aaatcagctt gaaacacgat 1395841 tagtacaagt tccggctcct gttgcccgcg aatttgagcc tgacactgag cttgatttgt 1395901 taaagattgc agttgtcgag cggcataaag gattaaaaga aaccggactt ggtgttgtga 1395961 aaggttttgg attcaagagc ggagcgattg ccacaaccat ttcacacgac tcccataata 1396021 ttattgccgt cggaacgaat gatgaggata tcgcggcggc agttaataag ctgcaggaaa 1396081 ttggcggagg attaacaatt ataaaaaatg gggaagagct ccattcagta ccgctgccga 1396141 ttgcagggtt attatccgac caatctgcag agcaagtgaa tcaaagcttg ctgacgcttc 1396201 atgataaatt gtcgttaatc ggtttcacag gcggatttaa tccatttttg acattgtcgt 1396261 ttttagcgtt gcctgtcatt cctgatatta aaatgacgac tacgggatta ttcgatgtaa 1396321 aatcatttca acacatatca ctgcaataaa aagaggcact cccttaggga gtgcctcttt 1396381 ttttaaacct ccataatgat cggcaggatc attggacggc gctttgtttt ttcgtacaag 1396441 aaaggtgcaa gcgtgtctgt aatttcgttt ttgatttcag accattgagt cgtttttcgt 1396501 tccattactt tttgtaagtg atttgaaatg agctcttgag cgtcgttgat caagtcacca 1396561 gattctctca tgtacacaaa tcctctggaa atcaaatcag gacccgctga aatcttgaag 1396621 tcgtccatgt caatgctgac aacaacgatg acaagtcctt cttcagagag aattctgcga 1396681 tcacgaagta cgatattgcc aatatcaccg ataccgcttc cgtcaatgta cactgaaccg 1396741 gacgggattt ttcctgcaac tgaagcctca tcgcctttaa gtgctaatac ttcaccatta 1396801 tccatgataa agcagttttc ctctgggatg ccacaatctg ttgcaagttt gacatgcatc 1396861 ttttgcattc tgtactcacc gtgaatcggc atgaagaatt taggcttgat taaacgaagc 1396921 atcagcttct gttcttcctg tccgccgtga ccggatgtat ggatatcgtt aagagggccg 1396981 tgaataacct cagcacccgc acgatacagc tggttgattg ttcgactcac gctgattgtg 1397041 ttgcctggga taggggatga agaaaatacg actgtatccc caggattgat tgaaatttgg 1397101 cggtgtgtgc cgtttgcaat tcttgataac gccgccattg gttccccttg gcttcctgta 1397161 cataaaattg ttactttatt agcaggcata cgattgattt cgttatgctc aataaacgta 1397221 tttttaggac agttaatata accgagtgtc tgtccaattt cgatagccga ttccatactg 1397281 cgtccaaata cggcaacttt tcttccattt tgtacagcag cttcaattac ctgctgcaag 1397341 cggtgaatat tcgacgcaaa tgtggcgaag ataattcggc cgtccacctt gcggaaaatg 1397401 tcatgaatgc tttctcctac acggcgctca gacatggtaa actccggatt ttcactgttt 1397461 gtgctgtctg aaagaaggca caaaacgcct tctttaccga tttcggccat tttcgttaag 1397521 tttgccggct cgccgactgg agtaaagtcg aatttgaaat ccccagtatg tacgatgttt 1397581 ccgggcggcg tttttacaac aatgccgtag gaatccggaa tactgtgtgt tgttctgaag 1397641 aatgacacag ccgttttgcg gaactttaca atatcatcct cgccgataat gttcagtttc 1397701 gtctgtctca ataatccatg ctcttcaagt ttattccgaa gtaagccgat cgcgagtttt 1397761 ccgccgtata caggaatatt cacttgtctg agcaggtatg gaataccgcc gatgtggtct 1397821 tcgtgcccgt gggtgataaa aagcccttta attttatctt cgtttttgac taaatacgta 1397881 taatcaggga tgacgtagtc aattccgagc agttcgtcct cgggaaactt gatccccgca 1397941 tcaatcagta caatttcatc ctggaattgc accgcgtacg tatttttacc gatttcgccc 1398001 aaacctccga gggcgaaaac agcagtctga tcatttttta caaatttcat accgctcata 1398061 actccaatac tttaaaattt tcgctctgtt gttcatattc taagaatgca ccatcaacag 1398121 gtgtaataaa ctcaatatta aatttctttt ctttcagctt tgttctgacg tcacgctcag 1398181 atacgccttc aatataaagt gaatctgtct tttcccgaac aggtacttcg tcagccttct 1398241 cttgataaaa taccttataa atcattccaa atctctcctt aaatgccgta tgttagactc 1398301 gctcattcta ttatattcga aaacggaata taaggaaagc cttgagcaaa ataaggatct 1398361 ctcaaaaagt gaaagatccc ttgtcaggca attgctttct tacggagcat tccgttccat 1398421 tgtcttctga gtttctttct taatttacgc agcattagcc agtccctcct ttaatgaaaa 1398481 atttgtccca gagttctttt atacaaatag tatacggaga ttgaggaaga cttttcgtgg 1398541 ttattaatgg aatttaatat gatttttgaa cgaaattgtt tgctgaatga caatcttttt 1398601 gtatgatgag ggtgggaatt gcagaccaag acgataaagg ggaagttgcg atggattcta 1398661 aattaatctt ttttgatatt gacggcacaa tatatgatca tgataagaat ataccggaaa 1398721 gtacgagaaa aaccgtggcg gagcttcagc gccaagggca tcatgtgttt attgccagcg 1398781 gccggtctcc atttttggtt aagccgattt tggaggagct gggcatccac tcatttattt 1398841 cctacaatgg acagtttgtt gtctttgaaa atcaagtgat ttataaaaat ccgctgcctg 1398901 aaaatgcaat caggcgatta ttaaagcagg cggatgaagg caagcatcct gttgtgttta 1398961 tggctgagga cacgatgaaa gcgactgttg cggatcaccc ccatgttctc gagggaatcg 1399021 gcagccttaa aacagattat ccagagaccg atgacctttt ttatgaagga aaagaaattt 1399081 ttcagcttct tttattttgt caggatgaag aagaaaaagc ttatgccgct tttcctgagt 1399141 ttgatctagt tcgctggcat gagctatcga ctgatgttct gccgcacgga ggttcgaagg 1399201 cagaaggaat caaaaaagtg attgagcgtc ttccgtttga tatcggcgat acatatgctt 1399261 tcggcgacgg attaaatgat ttgcaaatga ttgaatacgt tgggacaggc gttgctatgg 1399321 gaaatgctgt tcccgaactg aaagaaatcg cggactttgt aacaaaaccg gtggacgagg 1399381 atggaattgc atacgctgtc aaagaattgg gccttttaaa ataaagaaac ggctggcatt 1399441 gtgccagccg ttttctcttt tagcgctcaa ttgcgattgc attttcaggt tctttgaaag 1399501 gattttcctt atcaatatga tcatagaaca taacgccgtt caaatgatcg atctcatgct 1399561 gaaacacaat agccggaaat ccttttaaac gaatatcaat attttcgcct tctagtgttg 1399621 ttccttttac tctgatgcga gcatagcggg gaacataacc gggaatcgct tcatccacag 1399681 agaggcagcc ctcgccgctt gttaagtagc ttttttcaac tgaatggctg acgatcttag 1399741 gattaaacag agcatagctg tataatttac cggaagcatc ttccgcatga acggcgatca 1399801 ttcgtttttt gatattaatt tgaggagctg cgagtcctac gccagggcgc agcttgtatt 1399861 tttcggctaa ttctggattt tggctgtttt taacaaattc gatcatgtcg gccagctgct 1399921 gtttttctgc atcagttgga ggcagctcaa caggttcggc agtctctctg agggctggat 1399981 ggccgtcacg tacgatgttt tccatagtaa tcaagaaact tcactcctaa agcttaatat 1400041 gtaaattata tcggatttct tcacaaaggt gcaacgaaac gaatgaccag ccgtatatgg 1400101 ctggtcaatt tcatgctgtg tggttagcaa cagcctccac ctaaataagc agctccgaca 1400161 atgattaaca gaatgaataa aacaacgatt agcgcaaagg tgcggccgta gccatatccg 1400221 cagccaccat atccgtaacc accataactg cagcagcctc cgccgtaacc atatccatac 1400281 atattacata acctcctctt ttaattacgc cagagccttt ataagtaggc atagcgtcta 1400341 atataaccta tgtaaaaaca aaaaagttgt atggtcatct gtcctgattt ttcacttttt 1400401 tgatttaatt tcagtattgc atttatacag cacggctatt gccaaatgtc cccatggatt 1400461 ctatagtaga aattgtcaag attgggggat ttaacgtgaa agacgctata aaacggcggc 1400521 ctggaatcaa gatcggagct ttttgtgcca tggcactgat attaacagga tgcatgggac 1400581 aggacccggt tgattcactt catcattcat tagaaaaagc cgcggaatcg gaaaagccgt 1400641 ttcaagaaga acaaaacaca ctcaaagaat tagaggccaa agaaaatcag ctttacgata 1400701 gtgttatgaa gctcaatatg gatgattata aaaaaattgt tgctttatct aataaggcgc 1400761 ttgaaaatgt cagcaagcgc gaagaacacc taaagcttga aaatgacagc atgaaaaaat 1400821 cggaaacaga atttgaggaa gcaaaaacgt cagcggaaca tattaaggaa aaagacataa 1400881 aagaaaaggc cgatgccgca gcaaaccata tggagaaaag atatacatca tatggcacta 1400941 tgtataaaga gtataaaaaa gcgcttgagc ttaataaaaa actgtatatg cagctgaaag 1401001 acaaagattt gacaagagat gatctggatc agcagatcga taaagtcaat gcttcttatg 1401061 aaaagatcct taaatatagc ggagaattta atgaacaaac cgaaaaatat aataaagccc 1401121 gggaagattt atatgatgct gcaggctatc gtgtgaaaaa gagctgactc gatcagctct 1401181 ttttttgaat gaaatgcgat tcggatttcg ttcaaaattt tcatttctat tgtagtacag 1401241 catagtaagg tatactagta cagttttggg tgcggttggc atctgttttt ttgatgaaaa 1401301 tgtaaagcga atacatttat tgaaaatcag cgatgaaaac gattgacggt tcttctttat 1401361 ttggtgtaaa ctaatccatg ttaagcggtg ttgtattagt tttttacaac ttcgaaataa 1401421 tacagttcaa agcagagtgt aactatccta cataaaaggt tttggcaaac tggggatcgg 1401481 ctaaaatata atacgactta ctgctgatac tttagggtac cctaagtttg tatgtataaa 1401541 aggaatgcac gtctaatgac tgtttaaaag aaaggaagag gtgacttagt atggctgcaa 1401601 aaacgaaaaa agctatcgtt gacagtaaga agcaatttga tgccattaaa aagcagttcg 1401661 aaacgttcca aattttaaat gaaaagggag aagtcgtgaa tgaagcggcg atgcctgatt 1401721 taactgatga tcaattaaaa gagctaatgc gccgcatggt atttacgcgt gtgcttgacc 1401781 aacgctctat ctcattaaac cgtcaaggac gtctcggatt ttacgctcct actgcgggtc 1401841 aagaagcttc tcagattgca acgcatttcg cgcttgaaaa agaagacttt gttcttcctg 1401901 gataccgtga tgtgcctcag ttaatttggc acggccttcc attatatcaa gcgtttcttt 1401961 tctctcgcgg acatttcaga ggaaaccaaa tgcctgatga tgtgaatgcc ctttctccac 1402021 aaatcattat cggtgctcaa tacattcaaa ctgccggtgt tgcgctaggt cttaaaaaac 1402081 gcggtaagaa agctgtcgca atcacttaca ctggtgacgg cggagcttct caaggggact 1402141 tctacgaagg aattaacttt gccggagctt ataaagcacc tgcaatcttc gtggtgcaaa 1402201 acaaccgtta cgcgatttca actcctgttg aaaaacaatc tgcagctgaa acaattgcac 1402261 aaaaagctgt agctgccggt attgtcggcg tacaagtaga cggaatggat ccgcttgctg 1402321 tatacgcagc aactgctgaa gcacgcgagc gcgcaatcaa cggcgaaggt ccaacactaa 1402381 ttgaaacact tacattccgt tatggcccgc acacaatggc tggtgacgat cctactaaat 1402441 atcgtacaaa agaaatcgaa aatgagtggg aacaaaaaga tccgcttgta cgtttccgtg 1402501 cgttccttga aaacaaaggc ttatggtctg aagaagaaga agcaaaagtg attgaggatg 1402561 cgaaagaaga aattaagcaa gcgatcaaaa aagctgatgc tgaaccgaag caaaaagtaa 1402621 ctgatttaat gaaaatcatg tacgaaaaaa tgcctcacaa ccttgaggag caatttgaaa 1402681 tttatacaca gaaggagtcg aagtaagcca tggcgcaaat gacaatgatt caagcaatca 1402741 cggatgcgtt acgcacagaa ctgaaaaatg acgaaaatgt cttagttttc ggagaagacg 1402801 ttggtgtaaa cggcggcgta ttccgtgcga cagaaggatt gcaaaaagaa ttcggtgaag 1402861 accgtgtgtt tgacacgcca cttgctgaat ctggtatcgg cggtcttgcc cttggtttag 1402921 gcttaaacgg cttccgtccg gtaatggaaa tccaattctt cggatttgtt tatgaagtaa 1402981 tggattcagt ttctggccaa atggctcgta tgcgctaccg ttctggcgga cgctggactt 1403041 cacctgtaac aattcgttct ccattcggcg gcggtgttca tactcctgaa cttcacgctg 1403101 acagcttgga aggtcttgtt gcacaacagc ctggtatcaa agttgttatt ccatcaactc 1403161 cttacgatgc caaaggactt ttaatttctg cgatcagaga caatgatcct gttgtcttct 1403221 tagagcatat gaagctttac cgttctttcc gtcaggaagt tcctgaagaa gaatacacaa 1403281 ttgagcttgg aaaagctgac gtgaaacgtg aaggtactga tctttcaatc atcacttacg 1403341 gcgcaatggt tcatgaatca ttaaaagctg ctgatgagct tgaaaaagac ggcatttctg 1403401 ctgaagttgt cgaccttcgt acagtaagcc cacttgatat cgatacaatt atcgcctctg 1403461 tagaaaaaac aggacgcgcg attgtcgttc aagaggcaca aaaacaagcc ggtattgctg 1403521 caaacgtagt agcagaaatt aatgaccgtg cgatcctgag cttggaagca cctgtacttc 1403581 gcgttgcagc gccagataca gtatttcctt tctctcaagc ggagagcgta tggcttccaa 1403641 accataaaga cgttcttgaa acagcaagaa aagtgcttga attttaatca aactgcataa 1403701 tcgagaggga agatgaacgt tttccctcta ttatatatct gttttcaatg cttacgatgt 1403761 aaactttaaa attgcttaat caaactagga ggtcgagaac tgtggcattt gaatttaaac 1403821 ttccagatat cggggaaggt atccacgaag gcgaaatcgt aaaatggttt gtcaagccta 1403881 acgacgaggt agacgaagat gatgtactgg ctgaagtcca aaatgataaa gcagtagtag 1403941 aaattccttc acctgttaaa ggaaaagtat tagaattaaa agttgaagag ggaacggttg 1404001 caactgttgg acaaacgatt attacgtttg atgcacctgg ttacgaagat cttcaattta 1404061 aaggcagcga cgagtctgac gatgcgaaaa ctgaagcaca agttcagtca actgcagaag 1404121 ctggacaaga cgttgcgaaa gaagagcaag ctcaagagcc tgcaaaagct actggcgcag 1404181 gacagcagga tcaagctgaa gttgacccga acaaacgcgt gatcgctatg ccttccgtac 1404241 gtaaatatgc acgtgaaaaa ggtgtagaca tccgtaaggt tactggttca ggcaacaacg 1404301 gacgtgttgt aaaagaagat atcgacagct ttgtaaacgg aggagcgcaa gaagctgcac 1404361 cgcaagaaac agctgcacca caagaaacag ctgctaaacc ggctgctgca ccagctccag 1404421 agggcgaatt cccagaaaca cgcgaaaaaa tgagcggtat ccgtaaagca attgcaaaag 1404481 cgatggttaa ctctaaacac actgctcctc acgtaacgtt aatggacgaa gtggacgtaa 1404541 caaaccttgt tgcacatcgt aaacagttca aacaggttgc tgctgatcaa ggaatcaagc 1404601 tgacttactt gccttacgtt gtaaaagctc ttacatctgc actgaaaaaa ttccctgttt 1404661 taaacacgtc aattgacgat aaaacagatg aagtcatcca aaaacattac ttcaacatcg 1404721 gtatcgctgc tgacactgaa aaaggcttgc ttgtaccggt tgtgaaaaat gcagatcgta 1404781 aatctgtctt tgaaatttct gatgaaatca atggccttgc aacaaaagct cgtgaaggca 1404841 agcttgctcc agctgaaatg aaaggcgcat cttgcacaat tacaaacatc ggttctgccg 1404901 gcggacaatg gttcactccg gttatcaacc atccagaagt tgcgattctt ggtatcggac 1404961 gcattgcaga aaaagcgatt gttcgtgatg gcgaaatcgt agcagctcca gtcttagctc 1405021 tttctctcag cttcgaccac cgtatgatcg acggagcaac tgcgcaaaat gcattaaatc 1405081 acatcaagcg tttactgaac gatccacaat taattttaat ggaggcgtaa tgttatggta 1405141 gtaggagatt tccctattga aacagatact cttgtaattg gtgcgggacc tggcggctat 1405201 gtagctgcca tccgcgctgc acagcttgga caaaaagtaa cagtcgttga aaaagcaact 1405261 cttggaggcg tttgtctgaa cgttggatgt atcccttcaa aagcgctgat caatgcaggt 1405321 caccgttatg agaatgcaaa acattctgat gacatgggaa tcactgctga gaatgtaaca 1405381 gttgatttca caaaagttca agaatggaaa gcttctgttg tcaacaagct tactggcggt 1405441 gtagcaggtc ttcttaaagg caacaaagta gatgttgtaa aaggtgaagc ttactttgta 1405501 gacagcaatt cagttcgtgt tatggatgag aactctgctc aaacatacac gtttaaaaac 1405561 gcaatcattg ctactggttc tcgtcctatc gaattgccaa acttcaaata tagtgagcgt 1405621 gtcctgaatt caactggcgc tttggctctt aaagaaattc ctaaaaagct cgttgttatc 1405681 ggcggcggat acatcggaac tgaacttgga actgcgtatg ctaacttcgg tactgaactt 1405741 gttattcttg aaggcggaga tgaaattctt cctggcttcg aaaaacaaat gagttctctc 1405801 gttacacgca gactgaagaa aaaaggcaac gttgaaatcc atacaaacgc gatggctaaa 1405861 ggcgttgaag aaagaccaga cggcgtaaca gttactttcg aagtaaaagg cgaagaaaaa 1405921 actgttgatg ctgattacgt attgattaca gtaggacgcc gtccaaacac tgatgagctt 1405981 ggtcttgagc aagtcggtat cgaaatgacg gaccgcggta tcgtgaaaac tgacaaacag 1406041 tgccgcacaa acgtacctaa catttatgca atcggtgata tcatcgaagg accgccgctt 1406101 gctcataaag catcttacga aggtaaaatc gctgcagaag ctatcgctgg agagcctgca 1406161 gaaatcgatt accttggtat tcctgcggtt gttttctctg agcctgaact tgcatcagtt 1406221 ggttacactg aagcacaggc gaaagaagaa ggtcttgaca ttgttgctgc taaattccca 1406281 tttgcagcaa acggccgcgc gctttctctt aacgaaacag acggcttcat gaagctgatc 1406341 actcgtaaag aggacggtct tgtgatcggt gcgcaaatcg ccggagcaag tgcttctgat 1406401 atgatttctg aattaagctt agcgattgaa ggcggcatga ctgctgaaga tatcgcaatg 1406461 acaattcacg ctcacccaac attgggcgaa atcacaatgg aagctgctga agtggcaatc 1406521 ggaagtccga ttcacatcgt aaaataattt tcatatcaaa aacagccccg ctttgagcga 1406581 gggctgtttt tttattttga cagcacatgc tgtaatggtt taatgatgtc ttctttcttt 1406641 ttcacacatc cctcgatttt caccacgaca tggcgctgat caacaaccat aagggtaggg 1406701 acagtttcaa tctcatcttc ccagccttct tttttatcat agaccttcat tttatctatt 1406761 tgctcgggat aatctttttc taaatcaagc agtgcatcgt aataaggcgc ttcctggtct 1406821 atttggttct catcagaaaa aaacaggatt tgtgtatgat gaatgttgtc aatccggctt 1406881 tttttcatcg gattgatggt ggaaagcgta cagcccgata aagcaaatac tattatcagc 1406941 atggggaata ccgcgcgata tcgcatctat cttctcctct gtataaacag tagttaacta 1407001 gctttagttt atcacgagag acggcttaat ctgcttcttg ttacctaatt gttatataat 1407061 tgaaaccgtt tttaaagtga gattacatat tatatcaatc gtttaaaata gcaacctggg 1407121 gtatattgaa ttttttgctg cattcttgga tgaaagttca agaaaacgtg caattacatt 1407181 atgtgctgtg gcatatatat cgagtaaagc ttctgtatga agaagatatt gtatgatgga 1407241 aaatggaaaa acaaggtgaa tatgatgata tgaaataaaa tgtgttatac agtttgttgt 1407301 tgacatttta aatgtgacat attaatataa taacaacaaa agaaattaag cgttttcaaa 1407361 tttcaaagaa atggggaata agagatgggt acgattgttt gccaagattg caacgaagcc 1407421 attcattact ttgaagatga gaaagtgaca acattatatg gaacttgctg cggacaatgt 1407481 caatgtcctg ttgatgaaga gtaaaaaaaa gcatgcggct taaagccgca tgctttttat 1407541 tttttattga attgcttttt gttctttgat gacccggatc atatgtaaag tcgagtcctc 1407601 aggtccttga acagggaggc ctgcgtcaag gtttttaaaa atgtagctga tgttttcttc 1407661 tgtaataatt tctcctggga tgaagattgg aataccaggc ggatatacca tgacaaattc 1407721 agcaataatc cgtccggatg cttcttttaa tgggatgact tccgtatttg catagaaagc 1407781 atcacgcgga gtcattgcca ataaaggtat ttctggaagc agaacctcag tttgctgatg 1407841 tgttacatct tgttctgaca tttgctgtgc gatctcagtt aaagcctcta caagccggtc 1407901 tgcatcattt tggctgtcac caggagtgaa aatacacaaa atattgtaca gatcagaaag 1407961 ctccacctca atattaaagg attcacgaag ccatttttcc acgtcatgtc ctgtcaggcc 1408021 aagacttttc acagagataa tcaattttgt cggatcatag ctgtaagctg ctttcgaccc 1408081 aagaatctca gaaccgacac aataaatgcc ttcaatctga ttgaggcgat ctctcgtctg 1408141 attggcaagc ttgagtgttt cctcagcaag ctggcggcct tctgttgcaa ggcgttttct 1408201 ggcaacatcc aaagaagcga gaagcaagta agaagttgac gtagttgtca gcatgctcag 1408261 gatggattgc actctgtctt tagatacaag gccttctctc atgtttaaaa tagagctttg 1408321 tgtcagtgat ccgcccagct tgtgtacact tgtcgctgct atgtccgctc ctgcctgcat 1408381 agccgatagc ggcaattcgt cgtgaaaatg aatgtgaacg ccgtgtgctt catccacaag 1408441 cactggcaca tcaaacgaat gagcgagttc tacgatgctt tttaagtcgg ctgcaacacc 1408501 gaaatatgtc gggttgatga cgagaagccc ttttgcatcc ggatgctcgg taagcgcccg 1408561 tttagcagat tcaagtgtaa ttccgtggga gatgcccaat tcattgtcaa tttcaggatg 1408621 aataaaaatt ggaaccgctc cggaaaatac aatagctgtc ataattgatt tatgaacatt 1408681 tcttggaata ataattttat caccaggtcc gcaaacagcc attaccattg tcataatggc 1408741 gccgcttgtt ccttgaacag aaaaaaatgt atgatccgct ccaaatgctt cagcagccag 1408801 atcttgtgct tgtttaataa tgccttttgg cgcgtgcaga tcgtctaatg gttcaatatt 1408861 aatcaaatct atgcttaacg cgttttcacc gataaattgt ctgaattctg ggtccattcc 1408921 tgcccctttt ttatggccgg gaatgtggaa ttgaacaggc tgtctgcttg catgcttttt 1408981 cagtcctgtg tataagggtg tttcatgttg cgacaattgt tttcccacct ttgtaatcat 1409041 acctatgcat aatagtgtgt attaaaatca gtttctcaac cgttttttag acgtaaaaca 1409101 aatgaattat attatgaact tgaaagaatg taaagaacaa tttatgatca aatgaagatg 1409161 ctttctctta agggaagtaa atctacaagg agtgaagaaa atggagtatc aatatccgat 1409221 gaatgaagat tggacaaccg aagaagcagt ggatgtgatt gcatttttcc agcaggttga 1409281 gcttgcatat gaaaaagggg cggatcgtga agaactgctt aaagcttacc gccgtttcaa 1409341 ggaaattgta ccggggaagg ccgaagaaaa aaagctatgc ggcgagtttg aggaacaaag 1409401 tacatattct ccttatcgca cggtcaaaca ggcgagagaa tctgatcacg cgaagattaa 1409461 gatgtaagaa aaagagccgg gggatatccc ggctcttttt tatgcttgtg ttactttttg 1409521 ggtgagacgg tacagaaaag caagctgttt aaaggcatcg tcgatacgct gaaggaattc 1409581 ctggttattc atattcagca cttcttcttt ttggagctgg atgccgcata acagctcggc 1409641 tttctttaca gtctgcaaac gctcaaacag tgtcttcagc tgttccttgt ccatttcaga 1409701 ctgtttatgt actcccggtt ttgtgtgatc tgcagaccaa acgaagctgt cagggatatt 1409761 tttcgtaatg gtttcttggt tcacttcaag caatttgccg tattcttctt tgatagggga 1409821 ttcataaata atcgcgaacc atacaaagac gtggctttcc cataaaccaa tttggaaatg 1409881 cggcagtttt ttatagcctc ttttgctgtt tgcgaacgcc acccagctgt cagccggggg 1409941 attgacggat cttcttgcgt gctttgccac atgcggaaac atttcatctc cggttaaagc 1410001 tgataaagtt ggggcaaaat gttcgcctag agctgtaagc ttcggacgga ccgtctcttt 1410061 taatacttcc atgcgcgcgt ctaagccttc tattgtaaat gtgttaaagt cttcttcagt 1410121 gaaacgcatt tgtgtcatga ttttcctcct tcatgctaag tatacatatt ttatcacagt 1410181 tcatacgagc ttcaaaaaga ttgagcgcgt ttgaagtaag gagaaatgtg gtaataaacg 1410241 agtaggtaaa cacacaattt tcagaatcat gttgcgcgta aatagaacaa tcatacgata 1410301 taagaagtaa tcattgttga atggcaaaat gggatgcttt tttacaaaca aatgatctct 1410361 ggaaggggcg aaagacaatg aggcaagttg taaaagaggg atttaaggaa gagaaaaaca 1410421 atcgtgttgc tgtctggaga ctagaggttg attatgaatt ggcaacccta tatgaagcaa 1410481 tgcagaaaga aaatgaagag cagattgaac aaagcaaaaa caaacttgag cgacttagaa 1410541 aagaatggat tcgtcttaac gggtaaaaaa gcgatagtga aaacgaaccg catgaatggt 1410601 tcgtttttac gtgagaaggg atatttttca ttttccttgc tttttcattg ccgttatcag 1410661 tatcctataa aataaaaggt ctacatagaa gagaggtacg aacgaatgac aaattggacg 1410721 gaaatcgatg agattgcaaa gaaatggata agagaagcag gcgcgagaat tacacaatcc 1410781 atgcatgaaa gcctgacaat tgaaacgaaa tcaaatccga atgatttagt caccaatatt 1410841 gacaaagaaa ccgaaaagtt tttcattgat cgaattcaag aaacatttcc gggacatcgg 1410901 atactcggtg aagaggggca aggagacaaa atccactcac ttgagggagt cgtatggatt 1410961 attgatccga ttgatgggac gatgaatttt gtgcaccagc aaagaaattt tgcgatttcc 1411021 attgggattt ttgaaaacgg tgaaggtaaa atcggtttaa tttatgatgt ggtgcacgat 1411081 gagttgtatc acgcatttag cggcagagga gcttatatga atgaaacgaa gctggctcca 1411141 ttaaaagaaa ccgtcattga agaagcgatt cttgccatta atgcaacatg ggtaacggaa 1411201 aacagaagaa ttgatcaaag tgtgttagcg ccacttgtga aaagagtcag aggcacacgc 1411261 tcctacggtt ctgccgcttt agagctggca aatgtcgcgg caggaagaat agatgcttac 1411321 atcacgatgc ggcttgcgcc atgggactac gcagccggct gtgtgctgtt aaatgaagta 1411381 ggaggcacct atacgaccat tgaaggagag ccgtttacct ttttagaaaa ccacagtgtg 1411441 ctagccggaa acccatctat acataaaacg atatttgaag agtatcttca tgctcggaag 1411501 taggccattt gagcaggatg atctcagctt gttagaaaag ctcgcggagg ctcatcctgt 1411561 atggaaagag gaggagtttg gagataaaga tgcagaagac tatatcattt cctactccat 1411621 gtacaacggt tcatggcttg tatgggaaaa agacggtatg cctgttgccg tcagctacca 1411681 tctcgagtgg tctccttcaa acggtaagcc gtggctcgga acggtcctga ttgacccggc 1411741 tgaagaaaaa aagggacatg cgaagatgat cattgaacag atcagcaaat tgcttagagc 1411801 gaaacataaa gcgatgtttg cgggagttcc cattgagcgc agggaatgga tactgttttt 1411861 aagccaatgc ggctttgaac agctgaaaac ggaaaaagat gagaaaggca aatcatttat 1411921 gatcttggtg aagcctttag cagaagctgc cgtatgataa tggcagctta tttgctgcat 1411981 gcgggttcaa taaaaagcct ctcaaacatt gagaggcttc tgatgatttg aaaattattt 1412041 ttttaccgca tgaatataat gaatcgtttc aaacgctgac aaattgtctt ttcgattact 1412101 aaagaaaagg tcattgatgt cgtctggtga tagatgttca tagatcagta aaccagatga 1412161 ctctaacaga tgttcaatct cttgataagt gaaacatgat ttcatcggtt ccccgcttgc 1412221 ggcagccatc ttcaccatat gttcaactcg attcgacgtc ccttttgctg taaaaagtgt 1412281 ttcgtccgca taatcaaaaa caatagagct tccaggcggg acatgagaaa ataaattgct 1412341 gatcaagctt gcattttctt cccgtgttac ataataagac actccgagaa ggctgaagaa 1412401 tgtttttgtg tttttaaatc cttcatctaa gagaggatca tacgaaaacg ttttggtgaa 1412461 atccatagga acaaaatgaa gatgacccgg aattgtcaga tttgcatcct tcagcttatt 1412521 ttttttcaat tgctgtgtgg ccggatgatc aacctcgaaa acctgtaagc tgttttctaa 1412581 ttctggatgc cgaaagcaga aagtatccag tcccgctcca agaatgacat actgttttgc 1412641 ccccaggatt aattcgttgt gcaagacttt ttcacaataa gaagcacgtg ctaggggcgt 1412701 tggagacagc tggatttgtg caacccattt taatattttt tcaggatcat tttgaagacg 1412761 ttcggcgatc tctttgttga aaaacgatat ttcttgaatc atatttttac tgatgtcgat 1412821 aaactctttt tcgttaatga gatcttttgc gataaaatca tcaaaaataa gaggtgtgtc 1412881 atatcggctg tgatatgcac gggcaaaagc tgaaattaga gacgttaagc tggactcatt 1412941 tttcctcatg aaatgatcct ccacaaaaaa taagattccc ctggccagga gaatcttatt 1413001 atacatacaa atatattaat agtaaatttt agcataaata aatttttttg tcaatgtttt 1413061 tgctcttaac tggacgcgcg atccttcaca tagccacgtg acctgtagca gaattcgtct 1413121 atcaattatg tggactgaat cattagcttt tataaaatgc gcacttgcgg ctgcatccct 1413181 ctttatgcaa atcaggagcg gttttctgtc tcatggcagc atcttttcgt cgtttcagct 1413241 gagagagaaa tcaagatatg taacaataaa agcctgaggg atctcaggct tttcctaata 1413301 ttacaatcca acagcattcc aggctgcttc aactttagcg gcatcagttg agccgtagag 1413361 gtcacgggca gactgaatga gagctgcctt ggcatctttg aacgtggaag aaggcgtgag 1413421 gtacgttgtt aacgcacggt aatagatttg ctgtgattta gatacaccaa gttttgtgat 1413481 ggtgttgtaa gcggctttgt ttggaattcc gctgtttgtg tgtacaccgc cataatcgcc 1413541 ttcatctgtg tttggaaggt ttcggtaatt ggcgtaattg tcaggctggt tgtattttgt 1413601 agggttggac aggctgcgaa gagcaggctg gctgaccgta atgtcttcac cgatgtccca 1413661 gtcttctgta tcgttaaaat acccgaatac gtcagagaaa gactcgttta atgcacctgg 1413721 ctgattttca taaatcaagt tggctgtttc ttgggtgacg ccatgtgtca tttcatgcgc 1413781 tgtcacatct aatgagccgg aaagcggaga gaagaatgaa ccgtcgccat caccgtaaat 1413841 catctggtct cctgtccatg cagcgttatt gtattgagtg ccgtagtgaa cggaagaaac 1413901 gattttactg cctttgttat catagctgtt tcgtttaaag tttgaataaa aataatcgta 1413961 cactttaccg aggttatagt gtgcgtcaac ggctgcccgc tgtgatgaag atgtaaatgt 1414021 tttcgttgtg cttgagacaa gcgtgcccgg aaggcggctt tgtctgtttt gcaaatcata 1414081 tgtgatgatt tgggtgcctg ttggttttga aagatctctt agaacatatt ttccgccttc 1414141 ataagagatg ttcaaaggaa cagttgcgcc ctttagcgtt gttccgcttc cagtggcggc 1414201 ggcatgttct actttatttt gctgttttaa aatgctgcct gtttcggcgt caactaagac 1414261 ttcccagttt gcaggttcag gctcgacata gcgaatcgtc acgtcgtaag caagacgata 1414321 gctgccgtct tttgtttcta tcgcttttaa ttcggcttta ttgctgtttt tggccgctcc 1414381 gttagaaaca gcgtctggtg atttgccgat agctttgaaa gcgagtgcca gcgctttttc 1414441 agaagagact ttttggctgt tatctgtttt tgcagcagat tgattgtgta attcaccatt 1414501 gaccgcatag acattatcgg atttatcgac gtgaacgatc acttgcgaat ctttaattgg 1414561 cactccgtta acgacaggcg catatcgaaa gtgcttgtat ccaagggcat cagtcgtgct 1414621 ttcaacaagc ttcagccttt tggaagggtc acctttaaaa atgttgctgt tctttttcaa 1414681 aaactgcttg acagccttgt catttggtgc agagagttct gattgcgcaa tcgcgttttt 1414741 ggagaggaaa tttgtttgat tctctttaag ctgatgacct tcagcagcct gaacacctgg 1414801 caggctgatt gataaactca taaacgaagc agcgacagca acagacaatt tcttacctaa 1414861 acccacaata aatccccctt tttgaaaata ctgaaaactt tatattgtta tattaaacta 1414921 gcattctgga atactcaaca aaaactaaca taactagaca aaattgatag tattgtcctg 1414981 tgtttgtttt tgttgaataa tatcaagatg agtcaagtgt catgtggtgg ttcattcaag 1415041 agttatgttt tttacatatc aaggggaaga tgagatattt ttgtttcatc ttgaaacttt 1415101 ttgaaaagtc cgctgtctaa ccgaatgagg ccttaataag aagtaaagga ttgttgttcg 1415161 tgttggagtt attcagtcat tatgtattgc atttcgaacg ttattttata ttaagcagac 1415221 aaagcaccct gctgattcaa tggtcaattg ttgttctggc gggcttatat cttttggtgc 1415281 atcatcccaa aataaaccgg cagcgcacaa tgttcttggc gggtgttata ttgcggattg 1415341 tgctgctggc gggagtgtct gttgaactta ttcaccaggt gcaatcaaca aacttcacca 1415401 gcgcttactt aagagaggac ggaaaagaac tgctgccgct gctgcatttt ttgttatacg 1415461 gatatgtgct gctgacggct tttcactata tgctgatgcc gcgtgatcat ggcggaaagg 1415521 gtaagtttta tacgttcgac cttgctgttg tcagtttgcc gatcgtacaa atgattttta 1415581 gtttcttttc gtattggaag gaatacccgg atgggatgga gccgattgca ttcgtgtttc 1415641 tgtttttcat catcactctt cccattgcgt tgaatgtagt gtttttcaag ctgtattgga 1415701 gaacggataa gatcttacta ggcttatttt atacgctgat tatcggactg cttgtcttgc 1415761 tgcttgcgcc atatcccaat caaatctcaa aagattatgg tgcagtaatg ccatatacga 1415821 tttatttggc aatggcggga tttttgatga gctatcatct gttccaaaag tcaggaaagg 1415881 tttatgtgcg tgtgaataag tgggtgacga tggctgtcat ggtgtttttt gtcctgctgt 1415941 taaatccgat atataacata ggaacggctg ctttcgctgt atcaaagcca gcaaatgtcc 1416001 atgattcatt caattttgtc ggggagcaca tttcatcaga aaaagcggaa cagatactaa 1416061 agtcattttt tcctacggat gaaacacttt atttgcacga tacaaacatg gatgtgcatt 1416121 atttctactc atttgaaagc aaaggttaca aagctgaggt agatgaagta tcgcagctaa 1416181 ttcgtaatta tgaatactta caaaaagcac atgggaaaaa gctaacgaat caggagtaca 1416241 agcgaaagtc catcgctttc cttgagcgac acggacgtgt gttacataag gatcatatcg 1416301 aaacaaaggt atctcaagaa gacggccaga cagtcgtacg tatttacctg aaaaatcaac 1416361 ttcataaaaa agatcatgct gatgatggcg cggtatttta ttgggaaaag gaaaccttaa 1416421 tggggtttag tgaagatcct tcgatttatc agcttgactc tcttctgcat gttcatataa 1416481 cggaacaaga cattcacgac aaagtggaac aaatgtttac agcgctgaac atatcaaaac 1416541 agccttatca gatcactgat attgaaagcg acagcctgct tggaagcatg gtgagagttg 1416601 aaacaaaagt tggaattgtt ttggaatttg agggcgaatc aggttgttta catagtcttt 1416661 cgcttccgat gaaaaagaat atctcaatgg ctaacagccg gctgcagcat cagatattat 1416721 cgatcttcga tgctcgtgga tcagaaaaga agaaaaaaag cagtcagggt gacatggtga 1416781 tgtatactga ttcttctaaa acatatgagt ttgttgaagc tcaaggtcag ctaaacgttt 1416841 atgtatacag cgatacacct gatcagtcat tcccctatac gtatcgtaat ggaacattgg 1416901 cttacgaaaa agtagcttct ctatatcagg atgtcattta caaaaagcgt atgcgtccga 1416961 ttatcgttca aagaggggat gaacggcatt atgcatggct gatcattatt cagccgtttg 1417021 gttcaaatcg ccatgatgcc tatgtagtgg atggagaaac acaagaggtg aaaagtcttt 1417081 atgaatcata aagaaaaaga gtctgttttt gtagacttat acgacctgta taaagaagga 1417141 gagctagagg atgaatcaat ggaatggatg aaacagcatg aatccctatt tcaaaagaat 1417201 gcggaagact taaagagtaa aacttgttta aagagaagtc ccggtgctga agaagaaagc 1417261 caaatcagat atatgaaagt atacctgtct tccatgtata tctgtttcat tttattggcc 1417321 atttggatga cggtgtggtt ttatttttaa tgaagcatag ggattccatt gaggacttgt 1417381 atcggcagta ttatcaagaa attttaaatt atttattcag aaggactcat catcttgaaa 1417441 cagccaagga cttagcgcag gacacgtttg taaaagctct taacggtctg gcttcgttta 1417501 gggggcattc ttccatcaga acatggctct acaccattgc gcatcatacc tttatcaatt 1417561 ggtaccgaag ggatgtcaaa taccaattta ctgaaatcag caaaaatgaa gggttaacgc 1417621 aaacaactta tgaccagcct gaacagtatc tgtcacggac ggtgaaaagc gaaacactgc 1417681 ggcaggagct cctgaagtta aaagatcagc atcaatccgt tttgatttta agagaattcc 1417741 aagagctttc ttatgaagaa atcgctgaga tattaggatg gagtctttct aaggtgaata 1417801 ccacattgca ccgggctaga ttagagctaa agaaaaacat gacgaaaagt agagaggagg 1417861 agcggatatg acctgctttc tagtaagaga cctgcttcct ctgtatcttg aaggtgattg 1417921 taaaagagaa acggaacacg ttatagaaga gcatttaaaa atgtgcagca gctgcagaga 1417981 catgtatgac acgatggctg agccatttga attggaaagc gaacaggccg ttgaggaggc 1418041 ttatctgccg gaagaagaac tgcgttttaa acagaggtac tatggattac tgatcatgaa 1418101 agctgcctgc tggtttggag cggcggttgc catgatgctg atcatcaaac tgctgatata 1418161 aaaaaagcgc ttgtccgatt ccggcaagcg cttttttaca ttaagcctgg ggatgaatca 1418221 tatcgtaaat agcggcaagc tgttcttgtg acagggcact gaagagtttt tcataaacgt 1418281 cagcttgcag tggcgttgca cctgcttgta gcgctgcgtc tttatcatag ctgtacacat 1418341 catcttgtag cacaatggct gcttgaagaa tgtgaatctt gagagaaaca gcggagaaaa 1418401 attgttcaag tgcaagtgct tctttttctg tgaagccaag ttcaactgct ttttctgtat 1418461 caaatttgta atttccatcc tcgagataca cacattgtga aacaatgctg aaaaattctg 1418521 atgtcgattc ccagagtgta gcaattacct gagcctcttc ttttgtcatt cctaactcga 1418581 cagctttttc gctgtcaaaa taatatacac cgtcttgttc gtatatacat tgatttaata 1418641 tatcaatgaa tgtattgaga tcttcgttag tgctcgcctg atgctggagt tgaacagcag 1418701 tgttatcaac cggtgttttt gcgctggctg catcaggacc gaacgttaat agagcagctg 1418761 aggtcattgc ggcagtcgtt aacatagctt tttttacaaa tgttttcttc atgtttcttc 1418821 tctccctttt atgaattgtg ctacaaattc cattataggg agtagtttcc ggtggaggaa 1418881 taggcgctat ggtattttat gtgtatcgtt gccgaactac tttttgaagg ctgcacgtgt 1418941 gatcgttaga acgattgtct atgtatgaag gctgttttgc atcttcctga ctaagaaaca 1419001 ggggagataa ggcttaaaga aatgaaaaac accgctttct ttgcggtgtt ttttgattac 1419061 aatgtcgccg gcggggcaat gcttttaatc aagcaagcct tgttcgcgca ttttcttttt 1419121 taatgtaaat ccgccgccca tgacagcgca aacaagtaca atgctggcga taatgcctgc 1419181 agggcttttt tcagcgataa agacgccgat cagcataatg ctgaaaaccg ctgcaaatgc 1419241 aaataatagt aaaagccaat tcattttttt cataaattcc atcccctttt acgtcttata 1419301 ttaagtttac agaaaaacgt gacgctttta aagaggatgt gtgatataat atgaaagtta 1419361 tctaattttt ttaggagatg aaaaagtgaa acttcgaaat gatcttcgca acatcgcgat 1419421 tattgcccac gttgaccatg ggaaaacgac tctagtcgat cagcttttac atcaggctgg 1419481 tacgttccgt gccaacgaac aggttgctga acgcgcaatg gactctaatg atcttgaacg 1419541 cgaacgcggc attacaatat tggcgaaaaa tactgcgatt aactataaag atacacgtat 1419601 caatattttg gacacccctg gacatgcaga ctttggggga gaagtagaac ggattatgaa 1419661 aatggttgac ggcgtagtgc ttgtcgttga cgcatatgaa ggctgtatgc ctcaaactcg 1419721 ttttgttctg aaaaaagctc ttgagcaaaa cctgaaccct gttgttgttg taaacaaaat 1419781 tgaccgtgac tttgctcgtc cagaggaagt tatcgatgaa gttctggatc tgttcattga 1419841 gcttgatgcc aatgaagagc agctcgagtt cccagtggta tatgcttccg cgattaatgg 1419901 aacagcgagt cttgatccga aacaacagga tgaaaacatg gaagctttat atgaaaccat 1419961 tattaagcat gttccggcac ctgttgataa tgcagaggag ccgcttcaat tccaagttgc 1420021 ccttcttgac tacaacgact atgtaggccg tatcggaatc ggacgcgtat tccgcggcac 1420081 aatgaaagtc ggacagcagg tttctcttat gaagcttgac ggaacggcaa agtcattccg 1420141 tgttacaaag atttttggtt tccaaggctt aaagcgtgtg gaaattgaag aagcaaaagc 1420201 gggagacctc gttgcggttt ccgggatgga agatatcaac gttggtgaaa cggtatgtcc 1420261 tgtagaccat caagatccgc ttccggtcct tcgcattgat gagccgacac ttcaaatgac 1420321 atttgtcgtg aataacagtc cgtttgcagg ccgtgaaggc aaatatgtaa cggcccgcaa 1420381 aatcgaagag cgtcttcaat cacagcttca gacggatgtg agcttgcgtg ttgagccaac 1420441 agcttctcct gatgcttggg ttgtttcagg acgcggtgag ctgcacttgt caattttaat 1420501 tgaaaatatg cgtcgtgagg gctatgagct tcaagtgtca aaacctgaag ttattatcaa 1420561 agaaatcgac ggcgtacgct gtgagcctgt tgaacgtgtg caaattgatg ttcctgaaga 1420621 gcatactggc tctgtaatgg aatcaatggg tgcccgcaaa ggcgaaatgg ttgatatgat 1420681 caacaacgga aacggccaag tccgtctcat ctttacagtt ccttcccgcg gattgatcgg 1420741 ttactctaca gaattcctat cattaacacg cggattcggt attttgaacc atacgtttga 1420801 cagctaccag ccgatgcagg caggccaagt cggcggacgc cgtcaaggtg tacttgtgtc 1420861 aatggaaaac ggaaaagcaa catcatacgg tattcaagga attgaagacc gcggtgtcat 1420921 cttcgttgag ccgggtactg aagtatacga aggaatgatc gttggagagc ataaccgtga 1420981 caacgacctt gttgttaacg tcagcaaaat gaaacagcaa acaaacgtcc gttctgcgac 1421041 aaaggatcag acaactacaa ttaaaaaagc gcgcatcatg tctcttgagg agtctctaga 1421101 gtacttaaac gaagatgaat attgtgaagt aacacctgaa tccatccgtt taagaaagaa 1421161 gatcctcaat aagaacgaac gtgaaaaagc agctaaaaag aaaaaaacag caggattgtc 1421221 ttaatctcgt gcagaatttg aaaagataga acccgtacgt ttacagggga gggaatcttt 1421281 ttgaatgacg taagcgaacg cctgtcgttc ttcgccgctc tatatcaagt agaccggcag 1421341 cctgcggcag gcatgtggct gctgtacggc acgatttttg tgttggccgt tattgtattt 1421401 aagcttggat ttgctaaacg gcttcctgta ttaaaatctg cagtggtgta tgtatttttg 1421461 gctttgggct gcactgtttt gactttttta ggggtgtttt tgcccgtggc agaaggattg 1421521 gtcgtcgctg cgctgatttt aatcatttac aaaatccggc tgtatcagtc gaaaaaagga 1421581 cagtctgcaa aatcataaaa gactcagctg aaagctgagt cttttttgtg ttctgtatgg 1421641 ttaagcggcc gctttatttt ttgacttttt cttttttctg ctgtcccggg tgaaaagtaa 1421701 attttcccgt tttcagccgt tcctctgttt ttttggcaat ccgatcgtgg cattcctggc 1421761 acatatatgt atggatcggg cggtttcgaa gccgtttcgc gatcagggta tcatcatcaa 1421821 ttgtttcaat tttatcgcaa atagaacatt tgaccctcat catatcacct ctttcactaa 1421881 catgtattat accacggatc agaagctgtc caaaataaga aaaagctaaa gcgcaaggct 1421941 atagcttagt cattgttgtt ctttttcata tgatgatcag attgatcgtt ttgttccttc 1422001 tccatttcct gttgctgttt tctatttaat tggtcatttt gctgctttgt ttgcggttca 1422061 tcttcattgt caatcacatc gttaggcact tcgggaagca ctcggccgac aattgcagct 1422121 aattcatcca gtatacctgt taccggatgg ccctcgctga tttctctgct catttcgcga 1422181 aggcggctga ccgtatcggg atcagcaatg actactgcgt tggcgccata tcgatcattc 1422241 tttagcgcct gagctacaga atatttaatg gtttccactt tgcttctgtc caaagtatca 1422301 tcgacatcaa tcccaacaac agcatagcct cccagcacaa cggctgttgc atccttgacg 1422361 tcggggtttt tttcagcaac gctgacaaga tgcttggcaa tatccgttct tgttccattg 1422421 tcttttgttt cttgagttgt gtcctttacg tgaatcggtt tagtctcctg ctgtcttgtt 1422481 gattcttttt caacattctg gccctgtttt ccttgttgat aggcacaagc ggacaggata 1422541 agtgtcagct gtatgataat gaaaagaatt cgcacttgcg ggttccctcc ttaaaatgct 1422601 ttcattaatt ttattgttga attaaccttc tatctttatg cacaaaaaca tatattttag 1422661 caggcattca cctttttcat caaaagagaa gcaggaagaa ctttgaccct tatatcagga 1422721 ggctgagact tgagtaaaat ttatgtgtta gatacgaatg tgttattaca ggatcctaac 1422781 gcgatatttt cttttgaaga aaatgaggtt gtcatccctg ctgtcgtttt agaagaggtt 1422841 gattcaaaaa aacggtatat ggacgaagtt gggaggaatg caaggcacgt atctaagcta 1422901 atcgatgcgc taagacaaaa gggcaggctg catgagcatg taccgcttga caccggcggc 1422961 acactgagaa ttgaactgaa tcatcgttcg tttcaccagc tgcaagagat ctttattgaa 1423021 aagacgaacg ataatcgcat attagccgtt gcgaaaaact taagcctcga ggaagaaacc 1423081 aaggaaaatg gcaggccggt tatccttgtc agtaaggatg tactggtcag ggttaaagcc 1423141 gacgcaatcg gactgcttgc tgaagatttc ttgaatgacc gggttgtgga caatgatgaa 1423201 atgtacagcg gctataaaga tttatatatc agccagcagc tgttcagctc tttttacggg 1423261 aaaaatcaaa tttcagtaaa cgatgtgaaa cagcatgcgt tttatccgaa tcagtttgct 1423321 ttaatgaagg atgagctagg agggtcctcc tcggcagtcg gaattgcaga caaaaccgga 1423381 acggtattaa aaagactcgt atttgatgat gaacatatat ggggaatcag gccgaaaaat 1423441 gtacagcaga caatggcatt agagcttttg ctgcgggaag atattccgct tgtcaccctg 1423501 atcggcaaag cgggaaccgg caaaacgctc ttagctttgg cggcagggct attacagaca 1423561 gaagacttgg gaatatataa aaagctggtc gtcgcaaggc cgattgttcc tgttggcaag 1423621 gacatcgggt atttgccagg cgaaaaagag gaaaagctaa agccttggat gcagccgatt 1423681 tttgacaact tagagtttct gtttaatgcg aaaaaaccag gggagcttga tgctattttg 1423741 gcgggaattg gctcaattca ggtagaggcg ctgacttata tcagagggag aagcattcca 1423801 gatcaattta ttatcattga tgaagcgcaa aatttgacca ggcatgaggt gaaaacgttg 1423861 ctgacgagag tcggtgaggg cagtaaaatt gtcttaatgg gcgaccctga acaaattgat 1423921 cacccatatt tagacagtct gaacaatggt ttggcctatg tggttgagcg gtttaaagga 1423981 caacccatct caggcagcgt gaagctgtta aaaggtgaga gatcaggtct cgcccagctt 1424041 gcagctgatt tgctgtaaca cttaaatgat ttcgatctct tttacatcgg taatcggctg 1424101 tttgtgatga accgggtctt caaagtaaat atgcacgggg ccgccttctt gaatcggctt 1424161 gcctgcctca ctgaaatgga caatactgtt cagagcggtt tccagagaaa cggcggcctt 1424221 tcccgaactt gtgacaaata cacattgtgt cgcagagctg ttcggctcag catttttcag 1424281 gacagtccca agtctcattg cgaaactgcc gttcatcagt ttttgcttct catattgctt 1424341 ttccgtcttt aatgtaggcg gcgcgattcg cccctctctg atgacgcgtt ccggatcaag 1424401 gtcggattca tccccggctg attgtaaata tgtgtcttga ctgtcccctt tgcggtcaaa 1424461 cgaaaatttg cgatcatcaa aaatccatac gcttggatca atggtaattg gatatgtaac 1424521 attgcctttt acttggataa cgctcatgat atgaccccct tctctcaaaa ttataaaagt 1424581 tttcgcatga attgtcactt tgtgtacaaa ttatgtgtat tgaaatgctg agggaacgag 1424641 ggtgtttgca tggtatgcca gcataatgat gagcttgaag ccttagtgaa aaaggcgaaa 1424701 aaagtaacgg acaaggggga ggtagccagc tatattcccg ccttggcaaa agctgataaa 1424761 cacgacctgt cagtggcgat ttattattcc aataatgttt gtctgtcagc aggtgacgta 1424821 gaaaaaacat ttacgcttca aagtatatcg aaagtccttt cccttgcttt ggtgttaatg 1424881 gaatacggca aagataaggt cttcagttat gttggacagg agccgaccgg tgatccgttt 1424941 aattcaatta tcaagctcga aacagtgaat ccgagcaagc cgttaaaccc tatgattaat 1425001 gccggggcat tggtagtgac aagtctgata aggggaagaa cggtaaaaga gagacttgat 1425061 tatttgcttt cttttatcag aaggctgaca aacaaccaag agattacata ctgccgggaa 1425121 gtggctgaat ctgaatacag cacttcaatg attaatcggg cgatgtgtta ttatatgaag 1425181 cagtacggca tttttgaaga tgatgtagag gcagtaatgg atttatatac gaagcaatgc 1425241 gcgattgaga tgaacagctt ggatttagcg aaaatcggat ctgtattcgc attgaacggc 1425301 agacatccag agactgggga gcaggtcatc tcaaaagatg tcgctagaat ttgcaaaacg 1425361 tttatggtga cgtgcggaat gtacaatgca agcggggaat tcgcaattaa ggtcggaatt 1425421 cctgcgaaaa gcggcgtatc cggcgggata atgggcattt cgccttacga tttcgggatc 1425481 ggcatattcg gccccgcatt agacgaaaaa gggaacagca ttgcaggtgt aaagcttttg 1425541 gaaataatgt ctgagatgta caggctgagt attttttaat ttatgtcata tgcttaaatc 1425601 ctcttgcatt ttctgttgat accctttatg ataaatagaa gaattaggta ctcgcctggg 1425661 gaacggaggg atacttttgg cttcagagat gatagttgac catcggcaaa aagcttttga 1425721 actcttaaaa gtggacgctg agaagatttt gaagctgatc cgagtacaaa tggataactt 1425781 aacgatgcct caatgtcctc tatatgaaga ggttttagat actcaaatgt tcgggctttc 1425841 gagggaaatc gattttgctg tccgcctggg attggttgat gaaaaagacg gtaaagacct 1425901 tttatacaca ttggagcgcg aattgtctgc tttgcatgac gcgtttacag ctaaataaat 1425961 gataaaactc aaacttatta acagtttggg tttttttata accgctattt ttctctcatc 1426021 tcataaaaga cggtcttttt ttacacattc cttccgaatc gtatagagat tcttcgtctc 1426081 gtttgataaa ttgtagtaaa ataaaaaaga taaatacata aaaaccatag ataatggaag 1426141 ttagaagcag ggaagaggat gttatgttaa aaaaaatgct aaaatcttat gattactcac 1426201 tgatattcgc aatcgtttta ttatgcggat tcggtttagt gatggtatac agctcaagca 1426261 tgattacggc tgtctcccgg tatggagtaa gcagtaattt tttcttcatg cggcagctgt 1426321 ttgctttaat tgcgggtggc gctctattta ttctcatggc gttgtttcct tataaagcac 1426381 tggcccatca aaagtttcag aaggggatac tgcttgtatc tgttcttgcg cttatctcac 1426441 tgtttgtttt cgggcatgtt gccggaaacg cgcagagctg gtttaaaatc ggcggaatga 1426501 gtattcagcc gggggagttt gtgaaactgg tcgtgatttt ataccttgca gccgtatatg 1426561 caaaaaaaca aagttatatc gaccatctgt taacgggagt agcccctccg gtagtcatga 1426621 cgcttataat ttgtgggtta attgccatgc agccagattt cggtacagcc atgattatag 1426681 ggttaattgc gacgtgcatg atcttgtgct ccggcttcag cggaaagacg ctggtgaggc 1426741 ttgtgatact gggcggaatt gttttcattt tagtcagccc tattatctat ttgaatcagg 1426801 acaaaatttt aactgaaggc cgtttagcgc gttttgagag tcttgaagac ccatttaagt 1426861 atgcaaattc atcaggtttg caagtgatca attcttatta tgcgatcagc tcaggcggca 1426921 ttttcggcct ggggctcggt gaaagtatcc aaaaatacgg atatctgcct gaatcacaca 1426981 ctgactttat tatggctgtc attgctgaag agctcggcat ttttggggta ttgtttgtga 1427041 ttttcttatt gggttttgtc gtcataaaag gtttttatat tgccagaaaa tgcgaggacc 1427101 cgtttggaag tcttctggcg atcggcattt caagcatgat tgccatccag tcgtttatta 1427161 accttggcgg tgtcagcgga ttaattccga ttacaggggt tacgctgcca tttatcagtt 1427221 acgggggctc ttctttggtg ctgctgctgg ggagtatggg gatattagcg aatatcagca 1427281 tgtttgtgaa atattcagag aataagaaaa agaaagagcc cttggcgccg aagggaatga 1427341 aaaagaaaca gctcaaaaaa actgtttatc tgtaaaaaac aagtgtgtac aggggaagga 1427401 tattccgcta tgatagatta tattccattc gggtaagggg gagaaaagtt tgtctcagca 1427461 atcgatacaa aaagtattag tagcaaacag gggagaaatt gcaatccgaa tattccgggc 1427521 gtgtaccgag ttgaatattc gtacagttgc ggtctattca aaagaagatt ccggttccta 1427581 ccatcggtac aaagcggatg aagcatactt ggtcggtgaa gggaaaaaac cgattgatgc 1427641 ttacctggat attgaaggta tcattgatat tgcgaaaaga aacaaagtcg atgcaattca 1427701 tccgggatac ggtttcttat ctgaaaatat tcattttgcg agacgatgtg aagaagaagg 1427761 catcgtattc atagggccaa aatccgagca tctcgatatg tttggtgaca aggtaaaagc 1427821 gcgtgagcag gcagaaaaag cgggaatccc cgtgattccg ggaagcgacg gtcctgccga 1427881 aacgcttgaa gccgtcgaac aatttggaca agctaacggt tatccgatca tcattaaagc 1427941 ctcgcttggc ggcggcggcc gcggtatgcg gattgtcaga tctgaaagtg aagttaaaga 1428001 agcatatgag cgtgctaaat cagaggcgaa agcagccttt ggcaatgatg aagtttatgt 1428061 agaaaaatta attgagaatc cgaaacatat tgaggttcag gtcattggag acaagcaggg 1428121 caatgtcgtc catctttttg agagggattg ctccgttcaa agacgccatc aaaaagtcat 1428181 tgaagtggcg ccgagtgtct cgctgtcacc tgaattaagg gaccaaattt gtgaggctgc 1428241 agttgcgctt gccaaaaatg taaactatat aaatgcgggg acggtcgaat tccttgttgc 1428301 aaacaacgag ttctacttta ttgaagtaaa tcctcgcgta caagttgaac acacgataac 1428361 agaaatgatt actggtgtcg atattgttca aactcagatc cttgttgccc aagggcacag 1428421 ccttcacagc aaaaaagtaa atattcctga gcaaaaggac atttttacaa tcggctatgc 1428481 cattcagtca cgggttacga ctgaggatcc gcaaaatgat ttcatgcctg atacaggaaa 1428541 aatcatggct taccgctcag gcggcggttt tggtgtccgt cttgataccg gaaacagctt 1428601 ccagggcgcc gtgatcacac catactatga ttcacttctc gttaagcttt caacttgggc 1428661 tttaacgttt gaacaggcag ctgccaaaat ggtgcgaaac cttcaggagt ttagaatcag 1428721 aggcataaaa acgaacattc cgttccttga gaacgttgca aagcatgaga agttcctgac 1428781 agggcaatat gatacatctt tcattgatac aacgcctgaa ttatttaatt tccctaaaca 1428841 aaaagaccgc ggaacgaaaa tgctcactta catcggcaat gtgacagtga acggcttccc 1428901 tggaatcggg aaaaaagaaa aaccggcgtt tgacaaaccg ttaggcgtaa aggtagacgt 1428961 tgatcagcag cctgccagag gaacaaagca aattctcgat gaaaaaggtg cagaagggct 1429021 tgcaaattgg gttaaggagc agaaatctgt ccttttaact gatacgacat tcagggatgc 1429081 ccaccaatcg ttattggcaa ctagaatcag atcgcatgat ttgaaaaaaa tcgcaaatcc 1429141 gacggctgcg ttatggcctg aactattcag tatggaaatg tggggaggcg cgaccttcga 1429201 tgtagcctac cgattcctga aagaagatcc gtggaaacgt ttggaagatc ttcgcaaaga 1429261 agtgccgaat accttattcc agatgttgct tcgctcatca aatgcggtcg gctatacgaa 1429321 ttatccggac aatgtgatta aagaatttgt gaagcaatca gctcaatccg gtattgatgt 1429381 gtttcgtatt ttcgacagct taaactgggt aaaagggatg acgttagcca ttgatgctgt 1429441 tagggatacc ggcaaagtgg cagaagctgc gatttgttat acgggagata tccttgacaa 1429501 gaaccggacg aagtacgacc ttgcatatta tacatcgatg gcgaaggagc ttgaggcggc 1429561 cggagcccat attctcggga ttaaagatat ggcagggctg ttaaaaccgc aggctgcata 1429621 tgagctcgtt tctgcgttga aagaaacgat cgacattccg gttcaccttc atacgcatga 1429681 tacgagcgga aacggtattt atatgtatgc gaaagctgtt gaagccggcg ttgatatcat 1429741 agacgtggcg gtcagctcaa tggcgggatt aacgtcacag cctagcgcga gcggatttta 1429801 tcatgcgatg gaaggcaacg accgccgtcc ggaaatgaat gtccaaggcg ttgaattgct 1429861 gtcccaatat tgggagtcgg tgcgtaaata ttatagtgaa tttgaaagcg gaatgaagtc 1429921 tccgcatact gaaatttatg aacacgaaat gccagggggc caatacagca acctgcagca 1429981 gcaagccaag ggagtaggcc ttggcgaccg ctggaacgaa gtcaaggaaa tgtacagacg 1430041 cgtgaacgat atgttcggtg acatcgtcaa ggtaacgcct tcctcaaaag tagtcggaga 1430101 tatggcactc tacatggtgc aaaacaatct gactgaaaaa gacgtttacg aaaaaggtga 1430161 atctttagat ttccctgatt ctgtcgtgga gctttttaaa ggaaatatcg gccagcctca 1430221 tggcggattc ccagaaaaac tgcaaaagct gatcttaaaa gggcaggagc cgattacagt 1430281 cagaccgggc gaactgcttg agccggtgtc atttgaagcg atcaaacagg aatttaaaga 1430341 gcagcataac ttggaaattt cagatcagga tgctgtggca tatgcccttt atcctaaagt 1430401 cttcactgat tatgtgaaaa cgacagaaag ctatggagac atctcggtat tagatacacc 1430461 gacattcttc tacggtatga cattaggtga agagatagaa gttgaaattg agcgcggcaa 1430521 aacgctgatc gttaagctga tttcaatcgg tgagcctcag cctgatgcca cccgcgtcgt 1430581 ttatttcgaa ctcaacgggc agccgcgtga agtagtcatt aaagatgaaa gcattaagtc 1430641 ttccgttcag gaaaggctga aagcagaccg gacaaatcca agccacatcg cagcttccat 1430701 gcctggaaca gttattaagg tattggctga agcaggcaca aaagtcaata aaggtgatca 1430761 tttgatgatt aatgaagcga tgaaaatgga aacaacggtt caggcgcctt tctcaggaac 1430821 aatcaagcag gttcatgtga aaaatggtga gccgatccaa acgggagatc tgctccttga 1430881 aattgaaaaa gcataaaaaa caaagagtgt atatcaatga tatacactct tgttttttat 1430941 atagaaaatg tggagtgaaa cagatggtta gaagagatat aaggggactt cagagattat 1431001 agagtactgt cacaagccca aaataaaaag aggcttatac agccaatatt ttagatgctt 1431061 tgtagtatgc cgtgcatatt tctttaagca ctatctgatt taaaaggctt taatacttat 1431121 gttcgcgagc tatagatcca tatgaaattt ctataatcac gatgagaaag gggacagacc 1431181 gaagtgagcc gctcactgat catcaagttc ggcgaaggct ggcgattgaa acgcataaag 1431241 cgccaaaaaa caagacataa aaaagaccaa agccgcctaa ggctttggtc ttgagtcctt 1431301 atgattgcct ggattcataa cggaaacgag caatcaataa taagaagtag catagaacgc 1431361 caaacagaca ggcaataaag aacgagtggg caagtgcaaa gcccagagcc agttcagagt 1431421 atacgatcat aataccggac agtgcctgta atgtaatgaa aataagacat gagatccatc 1431481 cccaaaagat ctgtttttga tctttatagg aagtaatagc atgaacagcg gcaacaataa 1431541 tccatacaaa taaaagtaag gctgctgctc tgtggcccat ttgcacccat tcatggaatt 1431601 gggtcggaag tccattgttc agcgggctgc acagcggcac attaggacat gccagacttg 1431661 attcagtgtg tcttacatat gcgcctgtat acacaacgat ataggaatat attaaaattc 1431721 ctatcatgtg aaattgcatc tttttgccga tttgaagcgg cttaaccagt gttctgactg 1431781 atttatcagc ttcaaatatg agcaatgtta aaataagcac tgaagcaaaa gaaattaatg 1431841 agatgccgaa gtgaagcgcc ataatcagcg cgttcgaacc gaatacgaca gccaatgcgc 1431901 caagcaatgc ctgaagaaat aaaaagataa ttgacatgat cgcgagaaac gttgtttcac 1431961 gaaaaatcgg cgtgattttt ctccatgacc aaaacgcaag gcttagcaca aggataatag 1432021 agattccgct tgcgaatcgg tggctccatt caataattga agccggattc agttcaggga 1432081 aaaaacggcc gtgacacagc ggccactgtc tgccgcatcc ttggccggaa cctgtttttg 1432141 taacgagggc acccccgatt aaaacaatta gcatgacaaa tgtcgtcaga acaccgagag 1432201 cttttaatgc tttattcata caatattcac cttcttaaca tactgctgca attttatata 1432261 cgttccaagt gtaagcgaat atgtgttttg tggcaattcc cagagccttt tgttcacaaa 1432321 aatataatag aatgacggct tctggaaaat gtacacttga ttattcatgc cgggtctgat 1432381 agaaataagg taaacgcaat gccgatttgg agattgcctt catctttggt aaaattcata 1432441 aaaagttcac aaataaattc ctgtttgtcg tttaatattt aataggatgt ttttttacaa 1432501 gatgttatct tgtatgatag agttgcaggt tattttattc tcctgcgtta ggtttgtaag 1432561 ggaggtttac gttatggcta actccagaat cttaaatgat acagctatag acggacaaat 1432621 tgaagaaaca acggcatgga aagattttct gtcccttatt aaaataggga tcgtcaattc 1432681 taacctcatc acgactttca ctggaatgtg gcttgcactg catatatccg gtttaagttt 1432741 tttaggcaat ataaacaccg ttcttcttac gttaatcggg tcttcactga ttattgcggg 1432801 ctcctgcgcg atcaataact ggtatgaccg ggacattgac catcttatgg agcgtacgaa 1432861 agtaagaccg acggttacgg gtaaaattca gccgagtcag gcgttatggt ctggaatttt 1432921 gctggttgct ttaggattga tcatgctgct gatgacaact gtcatggctg ctgttatcgg 1432981 ttttatcgga gtctttacgt atgttgtatt gtacacaatg tggacgaaac gccgctatac 1433041 gattaacaca gtagtaggaa gcgtttccgg tgcagtgccg ccgcttattg gatggacggc 1433101 agtggaaggg aatatcggtg tcgtagcatg ggtgttattc atgattttat ttatttggca 1433161 gattcctcac ttcttagcat tggctattaa gaaaactgag gattacagag ctgcaaatat 1433221 tccgatgctt cctgtcgtat acggatttga agtgacaaaa agacaaatta ttgtgtgggt 1433281 tgcgtgcctg atgccgcttc cgtttttcct tggtagcctg ggtcttccga ttgtcattct 1433341 cggcttgctg ttaaatatcg gctggctgat tcttggctta atgggattcc gctccaagaa 1433401 tatcatgaag tgggcaacgc agatgttcgt ttactcgctt aactacatga caatctattt 1433461 cgttgccatg gttgtcttga cgcttttcta aaaaatagat atgatgcttg ttttatcgct 1433521 tcaaaataaa cgatgacaac tagtaaatgc cgccttgacc tcttgtttaa tcaggcggct 1433581 ttacttttat acatagatgg cattttgagt aaaaaaactc ataatttaag agaagaggaa 1433641 atgtaagtgc tttattggtg ataggttgga tggcgataga tttcgatccg ctttccgcct 1433701 ttgtattgac cagaaaaggg gttgggtgaa atggtaaagc attggcgtct tattttatta 1433761 ttagccttag tgccgcttct attaagcgga tgtggaaaac cttttttatc cacgctcaag 1433821 cctgctggcg aggtggctga taaacagtat gacctgacag tgctcagcac attgattatg 1433881 gtggttgttg ttgcagtagt atctgttatc ttcttttatg tgattgtgag attcagaaga 1433941 tcacgggtcg gtgagaacac gataccgaaa caggtagagg ggaataaatt tttagaaatc 1434001 acatggaccg tgatcccgat tttgctgctc attattcttg tgattcctgt tgtattatat 1434061 acgctggagc tagcggacac atcaccaatg gataaaaaag gccgcaaagc tgaggatgct 1434121 cttgtagtca atgttagggc aaatttatac tggtgggagt ttgagtaccc tgattacggc 1434181 attatcacaa gccaggagct gattgtaccg acagatcagc gtgtatattt taatttaaaa 1434241 gcctctgatg taaaacattc cttctggatt ccttcagttg gaggaaaact tgatacgaat 1434301 acggataatg aaaataagtt cttcctgaca tttgattcaa aacgaagcaa agaggcagga 1434361 gatatgtttt ttgggaagtg tgcagagctt tgcggccctt cacatgcgct gatggatttt 1434421 aaggtgaaga cgatgtctgc aaaagaattt cagggctgga caaaagaaat gaagaactat 1434481 aagtctacag cagagagcga tttggctaag cagggtgaag aactgtttaa agagaaaaac 1434541 tgcctgagct gccatgcggt agagccgaat gataagcgtg cagaagccgc tagaacggca 1434601 cctaacttgg cgaccttcgg tgaaaggaca aaagtggcag gggtgaaaga ggccaacaaa 1434661 gaaaatgtga aggcttggct gaaggaccct gacagcataa agccggggaa caaaatgaca 1434721 ggcacatatc caaagctctc agacagcgaa acaaatgcgc tttatgaata cttaaaaggc 1434781 ttaaaagcgg aaagcaagta gggaagaaag ggagatattg ggggaggtca catatgttga 1434841 atgcgcttac agaaaagcgg acgcgcggat ctatgctttg ggattatttg acgacggtgg 1434901 accataaaaa aatcgcaatt ctttatttag tggcaggggg attcttcttt cttgtcgggg 1434961 gaattgaagc gatgtttatc agaattcagc ttgcaaagcc ggaaaatgcg tttctcagtg 1435021 ctcaagcgta caatgaagta atgactatgc acggaacgac gatgatcttt ctggctgcga 1435081 tgccgctctt atttgccttg atgaatgcgg ttgtgccttt gcagatcggg gctcgggacg 1435141 tttcgtttcc atttttaaac gcgcttggtt tttggctctt ctttttcggg ggcattttct 1435201 taaatctaag ctggtttttg ggcggagcgc cagatgcggg ctggacatca tatgcctcac 1435261 tttcgcttca ttctaaaggg cacggcatag actttttcgt cctcggactc caaatatcgg 1435321 ggctcgggac gctgatagcc gggattaact ttttggccac gattatcaac atgagggctc 1435381 cgggcatgac gtatatgagg ctgcctttgt ttacatggac gacatttgtg gcctcggcat 1435441 tgattttgtt cgcgtttccg ccgcttacgg ttggattggc tctcatgatg ctggatcggc 1435501 tgttcggaac caatttcttt aatccggagc ttggcggaaa tacggtcatt tgggaacatt 1435561 tattttggat cttcggccac ccggaggttt atatcctaat tttgcctgca ttcggtattt 1435621 tttctgaggt catccctgtg ttcgccagaa agcgtttgtt tggctattct tcaatggttt 1435681 ttgcaatcgt gctcattggc tttctgggct ttatggtttg ggtgcaccac atgttcacga 1435741 ctggtctcgg cccgattgca aatgcgattt ttgcggttgc aacaatggct atcgcgattc 1435801 cgaccgggat taagattttt aactggctgt tgacgatttg gggaggaaat gtgaagtata 1435861 caaccgctat gctgtatgct gtctcattta ttccatcctt tgtgctcggc ggtgtgacgg 1435921 gagtcatgct ggcagctgct gcggctgatt atcagtttca tgatacgtat tttgtggttg 1435981 cgcacttcca ctacgtcatt attggcggcg ttgtattcgg ccttttagcc ggtgttcatt 1436041 tctggtggcc gaaaatgttc ggtaaaattc tgcatgaaac gatggggaaa atttcatttg 1436101 tattgttttt tatcggcttt cacctcacgt ttttcattca gcattttgtc ggcttaatgg 1436161 ggatgccgcg ccgggtttat acgtttttgc caggacaggg tctggaaacc ggcaacttga 1436221 tcagtacaat cggggcgttt tttatggcgg cagctgttat tcttctgctg gtcaatgtca 1436281 tatggacatc ggtaaaaggt gaatatgtag gtgctgatcc atggcatgac ggacgtacgc 1436341 tggaatggac cgtttcttca ccgccgccgg agtataactt taaacagctt ccttttgtca 1436401 gaggacttga tccgctttgg atcgagaagc aggcagggca caaatcaatg acgccggcgg 1436461 aaccggttga tgatattcat atgccaaacg gctcaatcct gccgctcatc atttccttcg 1436521 gcctttttgt cgcagcgttc gggctgctgt acagaagtga ttacgcttgg ggcctgccgg 1436581 tgatctttat cgggctcggc atcacattta ttacgatgct gcttcgttca gtaattgatg 1436641 atcacggcta tcatattcat aaagaggaac tgccgaacga tgataaaggg gtgaaggcat 1436701 aatgcaagtt caagaaaaat tcaccgcaga aacctttcca gcttctcctg aaaaagtaac 1436761 cctggaaggg aaaaataaat ttttaggctt ttggcttttt cttggcggag agactgttct 1436821 gtttgcgtct ctcttcgcca cgtttcttgc gcttcggaat tcaaatgccg gtgatccgcc 1436881 tacgacggaa atgttcgatg tgacacttgt attcattgcc acaatgcttc tattaacgag 1436941 cagtttaacg agtgtgtacg cgatgtacca catgaagaac ttttccttcg gcaagatgca 1437001 gctttggctg ggaattacga ttttattggg ggcgggcttt ttaggactgg aaatctatga 1437061 gttcaagcat tacacccatg aatttggctt taccatcaca agctctgccc ttggttctgc 1437121 gttttacacg cttgtcggta cacacggcgc ccacgtggca tttgggctta tgtggatcag 1437181 cacgcttatg atccgcaatg ccaagagagg gctgaatctg tatacggcgc ctaagtttta 1437241 cgttgccagc ctttattggc actttattga tgtcgtgtgg gtcttcatct ttaccgttgt 1437301 atatttaatg gggatggtgg gataaacatg gtcgataaaa aaagcagagg gcatatcaat 1437361 agcgaccttg aatttaagaa aaaaaagcat gcccgggaga tgaaatatca agtcctgtct 1437421 tttggtttaa tgatcggtct tacgattgtt gcatttctga ctgtggccac ggacggtgtc 1437481 ggcagctggt ttacgattcc tttcattatt ttgctagctg caattcaagt catttttcag 1437541 ctgtattatt tcatgcatat gaatcagaaa gggcatgagg cgccggcact gtttttgtat 1437601 tcaggggtgt ttgtcgcgtt tatcactgtg cttgcgtttg tgacaattat atggtggtaa 1437661 tttgaacagc cgccggaggt gaagaaatga atcagttgga gatatttggg tttcgcgcga 1437721 tgtggagccc ttatcttttt tgtatcctgt taggcattac ggcgctttat ctctattttt 1437781 acaggcgaat gtcttcaaag ccgaatcgaa taactggtaa agagatggtg tgctttctgt 1437841 cggcgatgct gtttttatat gcagccgagg gaagcccggt tgatctgctc ggacatatta 1437901 tgttcagtgc gcatatggtg cagatggccg tcctgtattt ggttgtcccg ccgctgttaa 1437961 tcgcggggat tcctgcatgg ctctgggaaa aaatcatttt caggccttca atcaaaccgg 1438021 ttttttcctt ttttacgacg cctttaattg ctttgctttt gtttaacggc attttttctt 1438081 tatatcatgt accgcttata tttgatactg tcaaaacaga tccgttttac catacattaa 1438141 tcacttggct tatctttgtg cttgcgttct tcatgtggtg gccgcttgtt cataaggttg 1438201 agcgtctacg gcagctcagc ggcttgatga agctgggtta tattatggcg gacggtatgc 1438261 tgctcacacc tgcttgcgcc ttgatcatgt tcagcggtgc accgttatac gccacctata 1438321 cagatccggc tttatgggct gaggcaatga ggctttgcgt gccagcggat atgatggggc 1438381 aggtcccatt aacagggcca gagatgttga atacactgcc tttgttagag gatcagcagc 1438441 tcggagcagt catgatgaaa atcattcagg aaattgtgta cggtactttt ttggccgtta 1438501 tttttttcca atgggtgaag aaagaaaggg aaaaggacgg gcaggaggag ccgccgtata 1438561 ttcagcagac gatatcataa aaggtacagc gaaatatgct gtaccttttc gttacatttg 1438621 aactgttttt aacatgttgg ctatgtcctg aatcagtgcc ttgctttttg tcacaacctg 1438681 tacgggaaac tcttccgttt ctccatattc tactccatga gggtagtaat gctttcctag 1438741 gagaggggac attaattgaa tcacggcgcg cccgcttccg acatcgcctt ctgccgcaat 1438801 accttgtatc cgcaggtaaa acgtaccctc aatcgtcgaa aacttcttgt cataggtgac 1438861 tctctcgtaa tcccattgac ccgctctgat aagacctttg ctttccatta agtcgtctag 1438921 ccagctgagc tcagccttaa ccccttcaag tccgctttca gtaaacttca acactgaccc 1438981 ctccttataa aaattacctt tcctgacaat catagtatga aagcgttaaa ctttcaatga 1439041 atcttcttct tttgaaagta tgcaaaaatt aaattttgac gacaatagca ctagactaaa 1439101 ggaggttaaa cggatgacaa aaataaaaga tctgatgaca gccgacttgc aatattgcac 1439161 ggtattagat aatgtatatg aagctgcagt aaagatgaag gacgcaaatg taggagcgat 1439221 accggtagtt gatgaggacg gggaaacatt ggtcggcatc gtaaccgacc gcgatctcgt 1439281 attaagagga atcgccatca aaaaaccgaa ctcgcaaaaa atcactgacg cgatgactga 1439341 aaaacctgtc agtgtggagg aagatgcttc agtcgatgag gttcttcatt tgatggcatc 1439401 gcatcagctc agaaggatac cagttacaaa aaataaaaaa ctgactggaa ttgtcacgct 1439461 tggtgatctt tctttatctg agcaaacgaa tgaacgtgcc ggcagcgcct tatcggatat 1439521 ttccgaaggg gataatagag aagaaggctt ttttcattaa cacataaatc tttgacatgt 1439581 taaataggct gtattgtaat gggatgtaaa caagagattg tgaatcgcca cgggggtgat 1439641 agattgaaaa atatattgag agcaatggtt atccttttga ttatctgcgg aacctatgtt 1439701 ctgtttattc aatatggatc tgttcctgaa aagaaatcaa atgacagcga gcctcaggtg 1439761 tcgaatgagg aagcgcaaag cggcaaacga atacatatgc cgacttcagg gttattgtcc 1439821 ttcatgggca agcacgccga tgaagtaacg aaaaagcttg gggaacctga acgtattgac 1439881 ccttcggctt atgattacga ttggtgggta tacaatcaag gtaaggatca atatatccaa 1439941 atcggggtat taaacaataa agtggtcaca ttattcgcgt cgggtaatga tattaacgcc 1440001 aagcctttca aaattggaga atcaactggc gaagtattca agaccaccca ggtggcacca 1440061 tttgtgaatg tagagtataa aggaaattcc tatcggtttg aattttctga agaagatatc 1440121 aatacaagac cgactgtaaa ggtaggaaag atgtatgtcc agctgtatat ggacaaattt 1440181 gaggggaagc tatccagcat cagggcgttt gatgcgcaga cctttgtaaa gcaaagacct 1440241 tatgaggtag tgtaccgcgg ggaattaatt aaaccgaaag ccgtttcaga tgagaaatgg 1440301 aaaaagatcc aaacaacgag cgaaaagcaa atccttgatt tgacgaatgt catacgcgtt 1440361 aaacatggac ttgcgaagct tgagtgggat cagccaacgg cggaagtggc atttgggcat 1440421 agtgaggata tgaaggaaaa taattatttc tcccatgtct ctaaaaaata cggctcgctg 1440481 aaagaccgct tagaagaagg gcatgttgat tttcagcaag cgggagaaaa tatcgcatac 1440541 aattatgtgg acggtccggc tgctgtagaa ggctggctga atagcgaagg ccatcgaaaa 1440601 gcgcttctga attcagatta tacgcatctt ggtgtcggag tagaccggaa atattacacc 1440661 caaaacttta ttaagcgatg gtaatgaaag ccgcggacga atggttcccg gctttttcta 1440721 tttccataca agctggtctg aatgaatgtg ctgatagctt acagataagg ccgtttccca 1440781 tcccttcagt caggcttttt caccagtgta tagggatatc gctaaaaatt catttgggaa 1440841 tgaatatagg cgaacacaat gcccgacaaa acgatacatt gtagtaggta acgattttcg 1440901 gagggggtga ggattgtggc gaatcaacat gccaatcatt caatcaatga ctttaaacaa 1440961 ttcgtcaaaa agcatcccaa gctgataaaa gaagtgcgca aagaacaaag aagctggcag 1441021 gacgtatatg aaaattgggt cctcttcggg gagagcgacc cgatttggga tccatatcgg 1441081 gaaccggaag aagcttctga agctgtgcct gaaacaccgc aaaaaaatga ttttgtctcg 1441141 aaaatggtga cagcggtgaa aaagatggat gtcaatcaaa tgaacgaaca aatcaataaa 1441201 atgagccagt cgatctcatc gttgcaaagc cttcttaata cattttccgg aagcggacag 1441261 aagcattctc agccaggctc tggacagcat cctttttctt ttcgaaagga ttaaaaaagg 1441321 ggagctcata tgcgcaaaga ggttcaggaa tatattttag caaacgaaga acggaaacga 1441381 ttcatcagag aacagccgat atggtaccgc aggctttcaa gaaaaccgga tgatctgtcc 1441441 tcctttcagc ttgaaatgat gaatttttat gaaaaaacca ttccgcatcg ggtgaatcag 1441501 tttacgaacg ggattcaaat ggcgcaaatg atgatgcaaa tgtttcaagc gatgcggaca 1441561 aaagattaaa aggccccgaa gaagggtctt ttttcatgcg gtcataaggt tttgttggcg 1441621 gctgcggtta agcattttcc aattggctgg tttcatggta aactaacaac tggaggtgca 1441681 tgttatgtat gcgacgatgg aatccgtgcg gcttcaaagt gaagctcagc agcttgccga 1441741 gatgattctg cagtcggaga cggctgagaa ctaccgcaat tgttacaagc gtctccagga 1441801 agatgaagag gcaggtcgga ttattcgttc ttttatcaaa ataaaagagc agtatgagga 1441861 tgtacagcgt tttggcaaat atcatcctga ctatagagaa atatcccgga aaatgaggga 1441921 gatcaaacgt gagctggacc tgaacgataa ggtggctgac ttcaagagag ctgaaaatga 1441981 gctccagtcc attcttgatg aggtcagcgt tgagattggg acagctgttt cggagcatgt 1442041 gaaagttccg actgggaacc cttattttga cggtttgtct tcatgcggag gcggctgcgg 1442101 ttcaggcgga agctgcggat gtaaagtgtc ctgacgagac tggccgtctc gtcttttaca 1442161 tataagagaa aacaggcagg tgattgtatt ggagaatagg cgccagggca tggttgtgta 1442221 tctgcactcc ctaaagcaga gcaaaatgct gaggaagttc gggaatgtgc actatgtatc 1442281 aaaacgatta aaatatgtcg tactgtactg tgatatggac caaattgaaa aaacaatgga 1442341 caagattgcg tcttactcat ttgtgaaaaa agtggagcct tcttataaac cgtttttaaa 1442401 attggaattc gagtcaaagc ttgataaggc aaaagaatac gattataaaa tcggcatata 1442461 gctataaaaa aatccccgca ggcatctgcg gggtccttct attccttaat atgttaagga 1442521 gaaggcaaag ggagaggaga aaccggagga agaacttatg gggaaacgta agtcttctcc 1442581 gcggttggca acaacatcct ctagatgctg ttgcttatag tatggacaag gatcatgctg 1442641 cctatacacc tgtttatcaa gattagcgtt cattgtttgg aagaatgctt tatgttaaga 1442701 taggattgat ttttttctat gtacatagcg gcgtccggcc gaataaagaa acaaaatagc 1442761 ttttagaaaa agtggtgtgg aacatgagag taatttctgg atcaaaaaaa ggccgttcac 1442821 taaaggctgt agccggaaca tcaacaagac cgacaaccga caaagtgaag gaatccattt 1442881 tcaatatgat cggcccttat tttgacgggg gcaggggact tgacttattc gcagggagcg 1442941 gaggtcttgg aatcgaagcg ctttcacgcg ggtttgagca ttgtatattc gttgaccgtg 1443001 attttaaagc gattcaaacg gtaaaatcta atttgaaaac gctggagctt acaaaacatg 1443061 cacaggtata ccgcaatgat gcggaacgtg ctttgcacgc tgctgctaaa agagaaaccg 1443121 gctttcgcgg aatttttctc gatccgccgt ataaggaaca aaagctgaaa gcacttttaa 1443181 ctttgattga cgaatatcaa atgctggaag aagacggctt tatcgtcgct gagcatgaca 1443241 gagaggtcga gcttcccgaa accgtaggag atcttgtgat gacaagaaaa gaaacctatg 1443301 ggttaacagg tgtagcgatt tataaaaaga gggggtagtg aggtggcgag tatagctgtc 1443361 tgtcccggca gttttgatcc tgtgacctac gggcatctgg acatcatcaa acgcggggcg 1443421 catatttttg aacaagtgta tgtatgtgtg ctgaataatt cttcaaaaaa gcctttgttc 1443481 agtgtggaag aacggtgtga gcttctgaga gaagtcacaa aagacattcc gaacataaca 1443541 gttgaaacat cgcaaggcct gttaattgat tatgcaaaaa gaaaaaatgc gaaagcgatt 1443601 ttaagaggct tgagagctgt atctgatttt gaatacgaga tgcaggggac atcagtaaac 1443661 cgggtgcttg atgaatctat tgagacgttt tttatgatga caaacaatca atattcgttt 1443721 ctaagttcaa gcatcgtaaa agaagtggca agatacaacg gctcggtatc agagtttgta 1443781 ccgccggaag tagagttggc gcttcagcaa aaattcagac aaggatgagg gttttgactc 1443841 atcctttttt tgttccgttt gtcagtctgt aagaaaaaat gataatgtac gtaaacagcg 1443901 cgcatagtgt gacagcaggt ccgatctgca caagcagatt ccagccgttt ataaaggcag 1443961 ttgacatgtc actgctgtta agagatttaa atacatactg atacggatca tgccatgctg 1444021 tgtaaagagg tttccataaa agcatgacga agacagcggc ataaacgccc tgcagcaaac 1444081 gtgcgataaa gaatggttta aatctaatgt cggtttccga taaaatacct gccacctgag 1444141 cttgtacgga aaagccgcta aacccaagaa taaagctgac gataatggct ttttgcagaa 1444201 gagaaacatc tgtctcgctg acaagcttgc tgcctaatgt aatttcaaac atccctgata 1444261 aaagcggaat gtccaattga gtcggaagct gaaacaaagt cagtgctcct tttgtgaaaa 1444321 cagacaaaac atcagtcagc tggaccactg acaacagccg attgaagaca gaaaataaaa 1444381 taataaagcc gcctaccata agaagcgttt gaacagaaga cgtcacggcg tcgcctaaaa 1444441 ttttacctaa gggccgtttt tctgcaagtc tggcggtatg aagagcgtgt aaagcatctt 1444501 tgactgaagg gaaaggtatc gttttctttc ttctgagatg ctgctcttcc ttgcggccat 1444561 aggagcgcat tgttaaaccg acggcaagat tccccaaata gtgtgcagaa gctaataaaa 1444621 tgcctagtga tgcgttttga aagaaaccga cggcaacagc gccgaaaata aagagcgggt 1444681 ttgaagaatt ggtaaacgac gcgagccgtt ctgcctctac tcttgaaatc tgattttcct 1444741 gccgcagacg ggcagtgagt tttgcgcccg ctgggtttcc tgatgccatt cccatagcaa 1444801 gaacgaagcc gccgacaccc ggcacgcgaa agatcggccg cataaaaggc tcaagcaaaa 1444861 caccgacaaa ccgcacaatg ccaaagccga ttaagagttc ggacagaata aaaaatggca 1444921 gcaatgacgg aaacacaacc tcccaccaca tagacagccc ggttttagag gcttcgaatg 1444981 aggcctgtgg atgtgagatg acagtcgctg ttaaaaaaag aaaaaacgag gcaatcaaaa 1445041 gtgtattaat cttcgacaag ttcattctta cctccccgat gctaaaaatg cccaatgaca 1445101 tgtatatcat gataaaataa tgtatgatgt aaaacggcca agcagtacct gtcctcttga 1445161 ttctttgtac taatatacga gcataggggt tcagtttaga ccatagaatt cggtatacag 1445221 ggaattcagg caggaggtta acgctttggc caaacctaaa atcgggttag cgttaggatc 1445281 gggaggggcc agagggcttg ctcatctcgg tgtgctttcc agtttacata agcaccaaat 1445341 tgaagtggat atgattgcag gaagcagcat gggcgctttg gtgggcagtt tttacgccgc 1445401 cggacatgac gtggcaacga tgaaaaaagt agccaaagcc tttaaacgaa ggctttatgc 1445461 tgattatacg gtgccgaaac tcggtttttt aaaaggtgac cgcgtcagac agcttgtgca 1445521 tgcttataca ttcggaaaac cgattgaaga gctccaaatc ccgctgggca ttgttgcgtg 1445581 tgatctacag acgggagaaa agattgtgtt ccgaaaagga tcagtgtcag atgcagtgag 1445641 ggccagcatc agcatcccgg gtatctttat tccgcagcgg ctggacggac gccttcttgt 1445701 agacggcgcg gtcgtcgatc gaattccggt ttctgttgtg aaagacatgg gagctgatat 1445761 tatcatcgct tcggatgttt ccagggttcg aaaaactgaa acagcagtgc atatttttga 1445821 tgtgattatg caaagtatgg atatactgca aaatgaatta gtgcggcatc aaacaattgc 1445881 cgcagatatc atgattcgcc cttcccttga aacatacagc tcaagctcgt ttgccaatat 1445941 tgaagaaatg atatcggcag gcgaagaggc gacaaaccga atgatcagca agataagaaa 1446001 agaaatagag aattgggagg gctcataatt tgctacgtaa aaaacatttt agctggatgc 1446061 tcgtcatcct catactgatc gccgttttat catttataaa acttccatac tatattacaa 1446121 aaccgggaga agcgacagag cttgcttcat tgataaaagt ggagggaggc tacccggaaa 1446181 aaggaagtct gtccttaatg actgttaaag tgggaccggc taatccattt acatatgtgt 1446241 gggcaaagat gcacccttat tatgaaattg ttcctgatga gagcattaag gaggaaggcg 1446301 aatcagataa ggagtatatg aaaagacagc tccaaatgat gaaaagctcg caagaaaatg 1446361 cggttatagc cgcctatcaa aaggcaggaa aaaaagtcag ctattccttt aacggcatat 1446421 acgcaagctc agttgtagaa aacatgccgg caaaagggaa aatagaagtc ggtgataaaa 1446481 tcatcagcgc agacggcaaa aactatcagt ctgctgaaaa gctgattgat tatatcagca 1446541 gcaaaaaagc gggagataaa gtcacgttaa agatcgaaag agaagaaaaa gaaaagcgtg 1446601 tcacccttac gttaaaacaa tttcctgatg agccggatcg ggcaggaatc ggagtttcgc 1446661 tttatacaga cagaaacgtg aaggtagagc ctgatattga ttttgaaatc gaaaatattg 1446721 gcggcccgtc agcagggtta atgatgtccc ttgaaatcta taatcagctg acaaaaccag 1446781 acgaaacaaa aggctacgat attgcgggaa caggtacgat tgatgttgac ggaaaagtag 1446841 gcccgatcgg cggcattgat caaaaagtcg tcgccgcaga caaagccgga aaagacattt 1446901 tcttcgcgcc aaatcaaaac ggcgccagca attccgatta taagaacgca gtaaaaacag 1446961 caaaagatat tgattcaaat atgaagattg tgcctgttga taccatgcag gatgcgattg 1447021 attatttgaa taagctgaaa gcgaaaagca cctgattctc aggtgctttt tctatacatt 1447081 taaaaagtgt tgttcatctt cgtcatatcg aatcggtgca tgtccgtatt cctgtaggtc 1447141 aaactcagtt ctcagcggct cttctatcgg caggctgtaa atcctgcttg cttttacgtc 1447201 cagatcgaga gctggatggg agaaagagga cagtttgctg acaagcggaa cagacagtgc 1447261 ttttttcttt tcggataaat aagcctgtcc ttttttcgtc atgccgagaa gcctgatata 1447321 cggcgcctta tcgttgtcaa gcagcttttg catatcctgt ttttttgttc tggttaaaat 1447381 gtgtgtattc atccgctgga gccttgtcca cgtatagcgt tttgttttca gcagttccat 1447441 aaattcctga taggagctgg attttctgat cgaacgaata attctgtgct ctaaaccttc 1447501 ctccacctcg tatacttgct gtaattcccg tgccgttaca gttgaaaggc tgtattttaa 1447561 gtaagaaaag tagctttcag gtgtatgcca caatccgaaa gatttgcggt aagctgctaa 1447621 ttcacgtgca gatgcagcag ggagaaaacg aaggcaggct tcgagattct ggccaatcat 1447681 cgcttttcta atgcttgtgg cacttgctat atggttttcg ccttcaggga gatcggcatc 1447741 atgatagtcc gaagagattc gtgccgtagt ataaggtttc ataggatatc ccccggttag 1447801 aatcgaggtc acatactggt atcccaaaat gttatttggt tttgacaagt caagtgcact 1447861 ttcagtatgc aaaatggagc tgaaggcgat agccgccgct gctgggtaac tggccccctt 1447921 tttaagttct tctttaattc ggtcattcaa tatatgttta tgctcatcaa taagctgtgc 1447981 tgtttctaaa aaaggcttga tatccccatt ttcactcccg aaaaacagcg cctcacattc 1448041 aagttcgttc aggatggaaa cactgccgcg tgcaaaaatg tctgcttttt gcacggcata 1448101 aagataaggc agctcaatga caagatcaac tccgctttgc agcgccattt ttgttcgggc 1448161 ccattttgat acaacagcgg gttccccgcg ctgtaaaaaa tgtccgctca tgaccgcgac 1448221 agccgtgtca catccggttt gcagctttgc tgtttgggca tgataaaggt gaccgttatg 1448281 aaagggatta tattcaacca ccaatccgac agctttcata ttttttccgc ctttcttgct 1448341 atgtttaaaa acgtatggta catttgcaaa tgaaaactct tacgccttat ttttgtttta 1448401 agtgtatgca tagcatattc cgctgtcaac gatacttcaa tggcagcatt atgctgtaaa 1448461 gaaaaaatat tgacaaaaac aatcttaaaa gctataatca tgtttgttgc tttcctgagg 1448521 tgatacaaat gaaatggacg atttatcagc tgcatcaaat gccaaaacaa agttttgagt 1448581 ttgatgaaac agttgagtta aatgagctga caaagctgaa ttctgacatt cgccgcattt 1448641 ctcccgttcg ggtgaagggc agagcggata tcaaatccaa acaggtttcg tttgatttta 1448701 caatttcagg cgaaatgctt ttgccatgct caagaacact cgttgatgtt ccgtatccat 1448761 ttgaaatttc aacaaaagaa ctgtttatat ttcatcacac ggatgatata gaagatgatg 1448821 acgttcacat tgttgaggac gatactatcg acataactcc gatcgtgaaa gaagaaattc 1448881 ttttagaaat ccctatgcaa atcttttgtg aatctgaaca agaaaaagga gctgctcctc 1448941 aagaaggaaa ggattggcaa gtcatttcgg aagaagacaa gaagaatcaa gttgatccga 1449001 gacttgcagc ccttgaaaag ctcttaaaac aagatgatga atcttaactc tttaaggagg 1449061 tgggaataat ggctgtacct tttagaagaa cttctaaaat gaagaaaaga ttgcgccgta 1449121 cacatttcaa acttaatgta cctggtatga cagaatgtcc gtcatgcgga gagatgaagt 1449181 tgtctcaccg tgtatgcaaa gcatgcggat catacaacgg caaagacata aatgtaaaaa 1449241 gtaactaatg agaaaagcgc agggtgaaag ccctgcgctt tttctttttc tcttcctgtc 1449301 agcttgcgga aaatttgtga gtgcaaatag tctatctaat ctattaccgg catatgtatg 1449361 agataaataa gctgacatgg agggagattg aatttgacca ttacaagaca agatgcttgg 1449421 actcaggatg aggatttgct gctggcagaa gtggtgcttc gtcatattcg agagggagga 1449481 acacagcttt cagcctttga ggaggttgga agggcgctga ccagaaccgc ggcagcctgt 1449541 ggtttcaggt ggaactcgta tgtgagaaaa caataccagt caggtataga gcttgcaaaa 1449601 aagcaaagga aagaactgag aaagcaaatc ggcgttcatt cggtcaatat gccgaattcc 1449661 atgaagcaga ctgcctcggc atcgtcagaa ggaaaacgag atttgtccat tcaggatgtc 1449721 attcaatttc tcgaacaatt caaagaaaca ccgtctgcac aagaatttca gcttgaaagg 1449781 gaaaaattga aggagcaaat ccaatcgctg caaaaagagc ttgaggattt gcggagtgaa 1449841 aatcagacat tgcggaatca gctagagatg acagaagagg attacaaggc actgatcgat 1449901 atcatggatc gggccagaaa aatggttgtt tcgaaggaag acggaagaat gaaaaaagcg 1449961 gctcaagaaa cgtaaagaaa cgcctgaaat gaaccggccc tatagtaaga ataggccggt 1450021 tgttttgatt tctatgcaga ctctcccggt gtcatttcgc gatccatatc aggatgccag 1450081 atgagcgggt tttccccttt gtcccgcgcc atatcatact taacagtttt aaagttcatt 1450141 ttgttccaaa attccgctga tttcattctc ggatttgtcc ggatcggcat tttgaatgat 1450201 tttgcaaatt caaccaaggc tctcccgtat cccctgttct ggtagcccgg aagaacctca 1450261 agcttccaca gctccaaata atcctggcgg ttgtcaaaat agggattcga tttgccgtta 1450321 acttgataca gactcattcg tgctacaagt ttatcgccaa aataaatccc gtaaaaaggc 1450381 gaggtgctgt cattttcaat aatattatcc tgaagttctt caagcattga aagctcctga 1450441 atgccgtatt ctttgaattt cttgaattct tccagcgttt tatagttgat aagcagacgt 1450501 tctacctttg tcaaacaaat ctcccccttt gttgtttcta catatattgt aaacgcttta 1450561 tttaaaaaat ccaaatattt aaactttaat tttaagcaca tgggatcttt gagaagtaat 1450621 ttcttcttac ttctgctatg ataatacgta aatgctaaat tgggtgtgac atcatgaaaa 1450681 ttggaattat cggcggaggc tccgttggtc ttttatgcgc ctattatttg tcactttatc 1450741 acgacgtgac tgttgtgacg aggcggcaag aacaggctgc ggccattcag tctgaaggaa 1450801 tccggcttta taaaggcggg gaggaattca gggctgattg cagtgcggac acgagtatca 1450861 attcggactt tgacctgctt gtcgtgacag tgaagcagca tcagcttcaa tctgtttttt 1450921 cgtcgcttga acgaatcggg aagacgaata tattattttt gcaaaacggc atggggcata 1450981 tccacgacct aaaagactgg cacgttggcc attccattta tgttggaatc gttgagcacg 1451041 gagctgtaag aaaatcggat acagctgttg atcatacagg cctaggtgcg ataaaatgga 1451101 gcgcgttcga cgatgctgaa ccagaccggc tgaacatctt gtttcagcat aaccattcgg 1451161 attttccgat ttattatgag acggattggt accgtctgct gacgggcaag ctgattgtaa 1451221 atgcgtgtat taatccttta actgcgttat tgcaagtgaa aaatggagaa ctgctgacaa 1451281 cgccagctta tctggctttt atgaagctgg tatttcagga ggcatgccgc attttaaaac 1451341 ttgaaaatga agaaaaggct tgggagcggg ttcaggccgt ttgtgggcaa acgaaagaga 1451401 atcgttcatc aatgctggtt gacgtcattg gaggccggca gacggaagct gacgccatta 1451461 tcggatactt attgaaggaa gcaagtcttc aaggtcttga tgccgtccac ctagagtttt 1451521 tatatggcag catcaaagca ttggagcgaa atacaaacaa agtcttttga gctttttcgg 1451581 taacatgcta tactcatttc ggatcactaa ctatttattg gagaaaggaa gttctagaag 1451641 atgcagctaa ctgaactttc catcaaaaat cagaatgtgt ttgtacagca ctatatagat 1451701 ggcaaagaag aaatgtcttc tttttttgat tacagtattc atcataagga catgtggcgc 1451761 gaaagactgg aagacttatc ttcccggttt ttcgcaagag aggaattggc ggcgtactta 1451821 acctcttacc ataataaatt cggttcaagt gcgatgcagt ctgctattga gaagctgaag 1451881 gacccgtcaa gtgccgctgt agtcggcgga cagcaggcag gacttttaac aggaccgctt 1451941 tacaccatac ataaaatcat ttcaatcatt gttttagcaa agcaacaaga aaaggaactg 1452001 caagtgcctg tcataccaat cttctgggtg gctggagaag accacgattt ggatgagatt 1452061 aattttgttc acacatctga agagaatggg cctgtgaaaa aaaagctgcc tcagtcttat 1452121 tggaagaaat catcagcagc gagtacatcg cttgatcagg aaaagtgtgc cgcgtggata 1452181 gatgatgttt ttgccgcttt tgaagaaaca gaccatacga atacacttct cgacaatgtg 1452241 aaacgatgtt taagggaatc tgttacgttt actgacttct ttgaactgct gatcgcggat 1452301 ttgttccaag aagagggctt agttttatta aattctgggg atccggggat taaaaagctg 1452361 gaaacggcca tgttccaaaa gattcttcga gaaaatgatg aactcgcccg ggctgtatca 1452421 gatcagcagg ccttcatgcg tcaagcaggc tacaaaccga ttatcgagtc cggaaaagag 1452481 caggcgaatc tgttttatga atacgaagat gagcgttttt taattgaaaa agataacggc 1452541 cgatttgtca tcaaagagct tgatctagga tggacgaggg atgaacttca tacacatatg 1452601 gaagaacatc cagagcgttt cagcaacaat gttgtaacga gaccgttaat gcaggaattt 1452661 ctcattccga ctttagcatt tattgcaggg cctggggaaa tcaattattg gggcgagctc 1452721 aaacaggcat ttgcggtgat gggcttcaaa atgcctcctg tcatgccaag gctgaacatt 1452781 acgatacttg agcggcatat tgagaaaaaa ctggctgaac ggaatatctc attacaagac 1452841 gcgattgagc gcggaacgga gaatcaaaga gagacatact tcgagcgcca gattccggaa 1452901 gagtttacgg cggtgatgga tcaggcgaaa agccaaattg aagcgattca caaaacggtc 1452961 cggcaggagg cgttaaaggt tgatcaaagc ttggaacctt tacttctgaa aaatgccgct 1453021 tttattcagg atcagcttca attcttagag cgcacggtga tgaagcgaat tgaagaaaaa 1453081 gaaggctacg tcttgaagga ttatgaaaga attcaaaata gcattaagcc gcttcttgcg 1453141 ccgcaagaac ggatttggaa tatcatgtat tatttgaaca ggtacggtcc aaaattcttc 1453201 acgacattca agaatctgcc attttctttt caaaatcaac atcaagttgt caaactttga 1453261 aataaagttt taaagaaccc tgactagttc agggtttttt tttatgggta aacagtgtaa 1453321 aatgaagttg tggagcgaag tggtgaatag tggtgagtta aggagagaaa gtggggcaag 1453381 agatcatgtt tatgggtgaa tatcagcata ccatcgatgc gaaaggccgc atgatcgtac 1453441 ccgctaaatt cagagaaggc ctaggtgagc aatttgtgct gactagagga cttgaccaat 1453501 gtctcttcgg ctaccctatg cacgaatgga aacaaattga agaaaaacta aaagctcttc 1453561 ctctcacaaa gaaagatgcc cgcgcgttta cccgtttctt cttttcaggg gcgactgaat 1453621 gcgaactgga taagcaaggc agggtaaata tcgcatcatc tctattgaat tacgccaaac 1453681 tggaaaaaga atgtgttgtt atcggggttt ctaatcgaat tgaattgtgg agtaaagtaa 1453741 tttgggaaca atacacagaa gagcaagaag attcatttgc tgaaattgct gaaaacatga 1453801 ttgggtttga tatataatga ttcttcgtgt ataacactct aaaaacaatt tcaattcatc 1453861 ctgataaaag gtgggaccaa cacaatatgt ttcaacacaa gacagtactt cttcgtgaaa 1453921 ccgtagacgg acttaatatt aaaccagacg gtacatatgt agactgcaca ctcggcggag 1453981 ctgggcatag tacatactta ttgcagcagt tatccgagaa ggggcgttta atcgcttttg 1454041 accaagatga tacggcatta cagcatgcta aagaagtgtt gtccgattat aaaggacagc 1454101 tcattctgat taaaagcaat ttcaggtatt taaaagaata tttgaatgaa caaggcgtta 1454161 cagaagtaga cggcatttta tttgatttag gggtgtcctc tccgcagctg gatacaccgg 1454221 agcgcggatt cagttaccat catgacgcac cgttggacat gaggatggac cagtcggcta 1454281 cgctttcggc gaaagaagtc gttaatgagt ggcgctatga ggatctcgtc cgtattttct 1454341 ttaaatacgg agaagagaag ttcagtaaac agatcgccag aaaaattgag gaggcaagaa 1454401 tgaagtctcc tattcaaact acgggccaac tggtcgatct aataaaagac gcgattcccg 1454461 ctccagcgag aaggagcggg ggacatcccg ctaaacgcgt gtttcaggca atcagaattg 1454521 ccgtaaacga tgaacttagg gtgtttgaag aagctttgga gcaggcaatt gaggttctga 1454581 agccaggggg cagggtatcg gtcattacct tccactcgct agaagacaga atttgcaaaa 1454641 ccacttttaa agaaaagtcg tcgcttccgg aacttcctcc gggacttcct gttataccgg 1454701 aagagtttga accggagctg aagctcatca cacgaaaacc gattacggca tctcaagaag 1454761 agcttgaaga gaacaaccgg gctcgttctg ccaagcttcg gattgctgaa aaaagaaaat 1454821 aacgaaacgc gaacgcaaaa ttaaaaggag gtcatcagcc tatgagcaat ttagcttacc 1454881 aaccagagaa acagcagcgg catgcgatca gtcctgagaa aaaagtgatt gtcaagaaaa 1454941 gggcttccat tactctcgga gaaaaagtgc ttcttgtcct ctttgctgcg gcggtgctca 1455001 gcgtatcgct tttgatcgta tcgaaggcgt atgcggcata tcaaaccaat attgaggtgc 1455061 aaaagcttga ggagcaaatt tcatccgaaa ataagcaaat tggtgacctc gaaaaaagcg 1455121 ttgctgattt aagcaaaccg cagcgcatta tggacattgc gaaaaagaac ggcttgaatt 1455181 taaaagataa aaaagtgaaa aacatacagg aatgattcaa atgccaaaaa agaataaatt 1455241 tatgaataga ggagcagcga ttctaagtat ttgtttcgct ctctttttct ttgtcatcct 1455301 ggggagaatg gcatatattc aaataaccgg aaaagcgaac ggcgaagtgc ttgcgacaaa 1455361 agcgacagag cagcatgaaa agaaacggac catcgaagcg agccgcggct cgattttaga 1455421 ccgaaaagga aaagtcattg cagaggacac agcgacgtat aaactgattg cgattctcga 1455481 taaaaaaatg accactgatg tcaagcatcc tcagcatgtt gtaaacaaag aaaaaacggc 1455541 ggaagcattg tctaaagtga taaacttgga caaggccgac atccttgata tcttaaataa 1455601 agatgcaaaa caagtcgagt ttggctcagc tggccgggat attacgtatt cacaaaagca 1455661 aaaaatcgaa aaaatgaaac tcccgggcat ttcattttta cgggatacaa aacgctacta 1455721 tccaaacgga gtatttgcat ctaatctaat cggctatgcc gaggttgatg aagaaacaaa 1455781 tgaaatttcc ggcgcgatgg gattagaaaa agtgctggat aagtatttga aggagcggga 1455841 cggatatgtg acatatgaaa gcgacaaatc cggctgggag ctcccgaaca gcaaaaataa 1455901 aattacagcg ccaaaaaatg gtgacaatgt atatttaacc attgaccaga aaattcaaac 1455961 ctttttggaa gacagcatga caaaagtggc gcaaaagtat aatccgaaaa aaatcatggc 1456021 cgcagtcgtt gatccgaaaa cgggcaaagt ccttgccatg ggacagcgcc caagctttga 1456081 tccgaacaag cgcgatgtga caaactacta taatgatttg atttcatatg cgtatgaacc 1456141 cgggtccacg atgaagatct ttacactcgc tgctgcgatg caggaaaacg tgtttaatgc 1456201 gaacgaaaaa tataaatcag ggacatttga agttggcgga gcacctgtta aggatcacaa 1456261 taacggtgta ggctggggtc cgacaacata tcatgacggc gtcctaaggt cgtcgaatgt 1456321 cgcttttgcg aaactggcga aagaaaagct gggatatgac cgcctcaatc aatatttgca 1456381 caaattcaat ttttaccaga aaacaggtat tgatttgcca ggagaagtct ccagcaaaat 1456441 caactttaaa tatgaatttg ataaggcgtc aactgcatat ggccaagcgt ctgcggtcac 1456501 accaattcag cagattcagg ccgcaacggc aattgcaaat gacggtaaaa tgatgaaacc 1456561 ttatgtcatt gaccatatcg ttgaccctga taaagataaa actatttatc aaaataagcc 1456621 ggaatcagcc ggaactccaa tttctgcaag tactgcgaaa aaggtgcggg atatattagg 1456681 agaagtcgtt acatcgaaga tcggaacagg gcaagcttat aaaatcgaag gttttgatgt 1456741 tgccgggaaa acaggtactg cgcaaatagc cggtaaaggc ggatatttag acggcacaga 1456801 taactatatc ttttcgttta tgggtatggc gccaaaagat gatcctgagc ttttaattta 1456861 tgttgctgta cagcagccgc aactaaaagc aggacaaagc agttcagatc cagtatcaga 1456921 aatcttcaat ccaacaatga aaaatagcct gcactaccta aacatcgaac caactgaaaa 1456981 atctgactca gataaggaag aaacaaaagc gcagacaatg cctgatttaa cagatcaaac 1457041 ggtagctgct gctcaaaaga aagcaaaaga ggagaatctc acaccaattg tcatcggcag 1457101 tgatgtcgct gtaaaagaac agtatccgaa agcggatgag gaagttctca ccaatcaaaa 1457161 ggtcttcctg aaaacgggcg gcaaaatcaa aatgcctgat atgacaggct ggtcgagaag 1457221 agaggttctg cagtacggcg agctcgcggg aattcatatt gaagtaagcg gacaaggcta 1457281 cgctgtcagc caaagtgtta agaaagacaa agaaatcaaa gacaaaaccg taatcaaggt 1457341 taagtttaaa aatcctgatt aaaaagaaag ccgtcgttat gcaggctttc tttttttatg 1457401 ccttcagagg agcatcgttc tacctgtcca aattcaggca taaaatgaaa caagcctaaa 1457461 taaggagtga acggtctctt gcgcgtctcg aatgtaacgg ttagaaaacg tttattattt 1457521 gttttgcttt ttggcgtgat cgtgtttctg atcattgata caaggctggg gtatgttcag 1457581 tttgtgatgg gcgaaaaact gacttcgcta gcgaaagatt cctggagccg gaacttgccg 1457641 tttgagccgg agagaggcga gattctggat cggaatggtg tgaagctcgc aacaaataaa 1457701 agtgcgccga ccgtattcgt cgtgccgcgc caagttcaga atccgatgaa aacgagcaag 1457761 cagcttgcgg cggtgctcaa tatgtcagaa gaaaaagtat ataaacatgt gacaaaaaaa 1457821 gcgtcaatcg aaaagatcac tcctgaaggg agaaaaattt caaatgagaa ggcgaaagaa 1457881 atcaaagcgc ttgatttaaa aggtgtgtat gttgcggagg acagtatccg tcattacccg 1457941 ttcggcagct ttttatctca tgtgcttgga tttgcaggaa ttgacaacca agggctcctt 1458001 ggacttgaag cctattacga cgatgattta aaaggggaaa aaggttctgt taagttttat 1458061 acagatgcca aggggaagaa gatgcctgat gaagcggatg actatacgcc gcctaaggat 1458121 gggcttgata tgaagctgac agttgattca aaggttcaga cgataatgga aagagagctt 1458181 gataacgctg aggccaaata tcatccggac ggcatgattg ccgtagccat gaatccgaaa 1458241 aacggagaaa ttttggggat gtctagcagg cctgacttcg accctgctga ttaccaatct 1458301 gttgatccgt ccgtctacaa tcgaaatctg ccagtatgga gcacgtatga accgggatct 1458361 acctttaaaa ttattacact tgcagcagcc cttgaagagc aaaaagtaaa tttgaaacgg 1458421 gatcaatttt atgataaagg gcatgctgaa gtggacggag cgagactgcg gtgctggaaa 1458481 agaggcgggc acgggctgca gacgtatctg gaagttgtgc agaactcctg caacccgggg 1458541 tttgttgaat taggcgagcg cttaggaaag gaaaagcttt tcaaatatat caaagacttt 1458601 ggttttggac aaaaaacggg gattgatctc caaggcgagg gaacaggcat cttattcccg 1458661 cttgagagag tgggcccggt ggagcaagca actacggctt tcggacaggg agtatccgtc 1458721 acgccgattc agcaggttgc agcagtatcc gccgctgtaa acggaggaac gctctataca 1458781 ccttatattg caaaggaatg gatcgatcct gttacgaaga aaacggtcaa aaaacaatca 1458841 ccaatcgcaa agaaacaagt catttctgag gaaacatcca aacaaatccg ctatgctcta 1458901 gaaagcgtcg tcgcagaagg aaccggccgc aatgcatttg tagaaggata tcgtgtcgga 1458961 ggaaaaacgg gaactgcaca aaaggttaaa gatggaaaat atcttgaaaa caaccatatt 1459021 gtatcattta tcggtttcgc gccagcagat gatccgagtc tagtcgtcta cgttgcggtg 1459081 gataacccga aaggcacgat tcagtttggc ggaacggtgg cagcgcctat tgtcggaaat 1459141 attatgagag acagtctgcc ggaacttggt gtgaagcccc ggaaaaatca aatcgagaaa 1459201 aaataccaat ggaacgacac aaaaacaata gaagttccga atgttgtagg gatgtctgtc 1459261 tcagatcttg agtcactatt ggtgaatctc aatgtggatg cttccgggaa agggagcaaa 1459321 atcgttaaac aatcgccagc tgccggaacg aaagtaaaag aaggctcaaa gatacgcgtg 1459381 tatttgactg aagaagatga aaaggaggca gccgattgat tcgggctgcc tattctttta 1459441 ttgcagaaaa aatgctgata tctttcaaga ttagctggat gtatcctttt atttacgcta 1459501 aaatatgaac tgtatgctta aaatcattac cacatcattt gatgtgactt caatgataaa 1459561 aagaacgaat tagaatgttg agaggtttga tacgatgaaa cttacaaagc tgcttacata 1459621 cttaacaacc gaaccttctg taaacgactc acaagaccct gaaataactt caattgagat 1459681 ggactccagg gaagtaaaga aagggagtct ttttgtatgt gtaaaagggt atacggtgga 1459741 tggccacgat tttgcgcaaa aagcagtaga aaacggtgca gcggctattg tggcagaaag 1459801 agaggtcgat gtgaatgttc ctgttattat tgtccggcag tcacttcgcg cgctcagcgt 1459861 tttgtctgat gcgttttacg gacagccgac gaagaagctt cagctgattg ggataacagg 1459921 gacaaacggc aaaacatcaa cgacccacat ggtcgatgag attctgaaaa aagcgggaaa 1459981 acgcacaggc ttgatcggta caatgtacat gaaaatcgga gacgaaacac ttcctgttaa 1460041 aaacacgact ccggaaagcg tcacgctgca gaaaacgttt aagaaaatga atgacaagca 1460101 cgttgacact gcaatcatgg aggtttcttc ccacgctttg tctttaggac gcgtccatgg 1460161 ctgtgattat gatattgccg tgtttacgaa tttaacacag gaccatctgg actatcataa 1460221 aacgatggat gagtaccggc atgcaaaaag cttgctcttt tcccaacttg gcggggcttt 1460281 caaccatgaa catccaaagc gtgccgtcct gaatgctgac gatgaggcga gcgcttattt 1460341 tgaaaaggta acagctgcgc atatctctac atacggaatt aaaaacgatg ctgatgtgat 1460401 ggcgaagaac atcagtatca ctgcacaggg cacaagcttt gatctcgtga caaacaaagg 1460461 cacgaagcac atcacgatgt ctctcgtcgg acaatttaat gtgtataacg tgctggccgc 1460521 tgttgcgaca tgtattgcag caggcatacc gtttgaaatc atcactgagg ctgttgaaga 1460581 attgcatggt gtaagaggcc gttttgaatt ggtcaatcag cagcaggagt ttcctgtcat 1460641 tgtagactac gcgcacacac cggacagcct tgaaaatgtg ctggagacat gcagagacat 1460701 gacggaagga aagctatttg tcgttgtcgg ctgcggagga gacagagata agacgaagcg 1460761 cccgaaaatg gctaaaattg ctgtggagct ggctgacgag ccgattttca cgtcagataa 1460821 cccgagaagc gaagatcctc gcgcgatttt aagagatatg gaagccggag tagagaacgc 1460881 atactatcac agtattgcaa accgcgagca ggcgatcttt ttcgcaattg ccaatgccaa 1460941 aaaaggcgac gttgtcctca ttgccggaaa aggacatgaa acctatcagc agatcggaaa 1461001 tgaaactttc gattttgatg atgctgaagt agcggcgaga gccattgttg aactcaataa 1461061 gaataagacg aattcatagg aaagagatgt tactgaataa tggagcttga aaagattttt 1461121 catatggaaa aaaatcatga atatgataac tacgtatgtc gtttgaaaga aacaggagga 1461181 gaaaaggaca atgcttgagc aagtcattct gtttacaatt ttaatggggt ttttaattag 1461241 tgttctgctc tctccgattc ttattccgtt tttaagaaga ttaaaattcg gccagagtat 1461301 tagagaagaa ggaccgaaat cacatcagaa aaaatcaggg acaccgacaa tgggcggggt 1461361 catgatcata ctttctatca tagtgacaac aattgttatg acacagaagt tttcagaaat 1461421 aagccccgaa atggtgctgc ttctgtttgt tacgctaggc tacggtttgc ttggcttttt 1461481 agatgattac atcaaggttg tcatgaagcg caatcttgga ttgacatcaa agcaaaagct 1461541 gatcggacaa attattattg cggttgtatt ttacgccgtg tatcattact acaattttgc 1461601 gacggatatt cgcattcctg gaactgactt atcatttgat cttggctggg cttactttat 1461661 ccttgtgctc tttatgctag tcggcggatc aaacgcagtt aacctgactg acggccttga 1461721 cgggttatta tccggtactg cggcgattgc ctttggcgcc tttgccattc tggcatggaa 1461781 tcagtctcaa tatgacgtag cgattttctc agttgccgtt gtcggtgcag ttctgggctt 1461841 ccttgtattt aatgctcatc cggccaaagt ttttatggga gatacgggat cgcttgcatt 1461901 gggaggagcc atcgttacca ttgccatttt aacgaaatta gagatcctgc tggttatcat 1461961 cggcggtgta ttcgttatcg agacattatc cgttattttg caggtcatca gctttaaaac 1462021 gacaggtaaa cgaatcttta aaatgagtcc gcttcatcac cattatgagc ttgtcggctg 1462081 gtctgaatgg agagtagtcg tgacgttttg ggctgcggga cttttgcttg ccgttttagg 1462141 aatttacatc gaggtgtggt tataagtgga aaatgatcaa tttttacaga aacagcattt 1462201 tttaatcctt gggcttgcga aaagcggata tgcggcggcc tccattcttc atgaaaaagg 1462261 catttatgtt gcagtcaatg atcaaaagcc ttttgaagaa aatgaaccgg cacaaaagct 1462321 ttctgaaaaa ggaatcgaag ttgtttgcgg agagcatcca gtttctctgt tcgatcagca 1462381 tcaaatcacg attctgatca aaaacccggg aattccttat gaaaatatca tggttcagga 1462441 agcagagaaa cgaggtattc cggtttggac ggaaattgag ctcgcttact acctgaccag 1462501 cgccaagttt atcgggatta ccggatcgaa cggtaaaacg accacgacaa cgctaattta 1462561 cgaaatgctc aaggctgact cgcaaaaagc actgattgcc ggaaacatcg gcacagtcgc 1462621 aagtgaggtt gcctatcatg ctgatggaga tgaatggatc gttaccgaac tgtcttcgtt 1462681 tcagctgatg ggaacacacg ctttcagacc ggaaatcagc ctgattttaa atgtatttga 1462741 cgcccatctg gattatcacc atacgcgcga aaactatgaa aaagcgaaac agaaagtgta 1462801 ccttcatcag actgcttcag ataaagctat tgtcaaccag gatgatgaaa ccgtcgtgcg 1462861 tcttgctgaa gccggaaaag ccgaaatcgt cccattttca gtcagcaaaa cgcttgaaca 1462921 gggcgcatat gtaaaagaca gtatgattat gtttaacggc gaagccattc ttcctctgga 1462981 agaggttgta ctgcccggtg ctcataacct ggagaacatt ttagcagcta ttgcagttgt 1463041 gaaaacggca ggagcatcca atgaggcggt taaaaaggtg ctgacaagct ttactggtgt 1463101 gaagcaccgc ctccaatatg tcacaactgt gaatggccgc aaattttata acgacagtaa 1463161 agcaacaaac attctggcga caagcaaggc gctttcagct tttgataagc cggtcattct 1463221 gcttgcgggc ggactggatc gcggaaatgg ttttgatgac ttgaaacctt atatgaagca 1463281 tgtcaaagca gtgcttacat ttggccagac ggcgccaaaa ctcgagaaac tcggcaatga 1463341 actgggaata caacatgtca aacgtgtcga taatgttgaa caagcagtat ctgcggcgtt 1463401 tgcgctctca aatgaaggag atgtcatcct gctgtcaccc gcgtgtgcga gctgggatca 1463461 attcaaaaca tttgaagaac gcggtgacat gtttatagat gccgtgcata tgcttaagta 1463521 agggcttgtc ttgaagtaaa tcggcagccc taatgacttt aagcttgggg tgtcgattgc 1463581 tttgactact aaaaaaacat cgcctgattt gttattggtc atcattacgt tattattatt 1463641 aacaatcgga ttaattatgg tgtacagtgc gagtgcggta tgggcggatt ataaatttga 1463701 cgactcattc tttttcgcga aacggcagct tttgtttgcg ggaatcggcg tcattgctat 1463761 gttttttatc atgaatgttg attattggac ttggaggaca tggtccaaat tgctgatggt 1463821 tatctgcttt ttccttctgg tgcttgtttt gataccgggc gtcggaatgg tgcggaacgg 1463881 ttcaagaagc tggatcggag tcggagcatt cagcatacag ccttcagagt ttatgaagct 1463941 tgcgatgatt gcattccttg ctaaatttct ctctgaaaaa caaaaaaaca tcacatcgtt 1464001 cagacggggg ttcgtccctg cacttggcat cgtgttttca gcatttttga ttatcatgtg 1464061 ccagcctgac ctcggaacgg ggacagttat ggtcggaact tgtattgtca tgatttttgt 1464121 agccggcgca cggatcgccc atttcgtctt tctcgggctg atcggcctca gcggatttgt 1464181 cgggctcgta ctatcggctc catatcggat aaagcggatt acctcatact taaatccatg 1464241 ggaagacccg ctcggaagcg gatttcagat cattcaatcg ctttatgcag tggggcccgg 1464301 cgggttgttc ggaatggggc tcggacaaag cagacagaag ttcttttatc tgcctgagcc 1464361 gcaaacagac tttattttcg ccatcttgtc agaggagctg ggctttatcg ggggaacact 1464421 tattttgctc ctcttcagcg tcctgctgtg gagaggaatc agaattgcgc ttggtgcgcc 1464481 tgatctgtac ggaagctttg tcgcagtcgg cattatttca atgattgcca ttcaagtcat 1464541 gataaatatc ggcgtagtca cgggcctgat tcctgtaaca ggcatcacgc tcccgtttct 1464601 gagctacgga ggctcttcat tgactctaat gctgatggca gttggtgtgc tgctgaatgt 1464661 aagccgctac tcgaggtatt aacgaatgta tttccaagcc tcctgtctaa catgaagctt 1464721 ggaaacaatt gatgcgataa ccctgtccaa caaaacaggg ttatcgttat gttatagaga 1464781 aacttagact gggggaaaaa agaaatgcga attgcaataa gcggaggcgg tacaggggga 1464841 catatttatc ctgctcttgc ttttattaaa gaagtgcaaa gacgtcatcc taatgtggaa 1464901 tttttatata tcggaacaga aaacgggctg gagaaaaaaa ttgttgagcg ggagaatata 1464961 ccgtttcgtt caattgaaat tacaggattt aaaagaaaat tgtcatttga aaatgtcaag 1465021 actgtgatgc gttttctgaa gggcgtcaaa aagagtaaat cgtatttagc ggaatttaag 1465081 cccgatgccg taattggaac gggcggttat gtatgtgggc cggttgtcta tgccgctgcg 1465141 aaaatgggaa ttccgactat tgtccacgaa caaaacagcc tgccgggcat cacgaataag 1465201 tttctttcaa aatatgttaa taaagtagcg atttgttttg aagaagcgaa atcacatttt 1465261 cctagcgaga aagttgtatt tacgggaaac ccgagagcct ctgaagtcgt ctcaataaag 1465321 acgggacgat cattggctga atttgggctt tctgaagaca aaaaaacggt cttaattttc 1465381 ggcggaagcc gaggcgctgc accgattaac cgcgctgtca ttgacatgca ggatgtgctg 1465441 aaaacaagag actatcaagt gctgtatatc accggtgaag ttcactatga aaaagtaatg 1465501 aatgagctga aaagcaaggg tgccgctgat aatatggtca caaagccgtt tcttcatcaa 1465561 atgcctgagt atttaaaggc cattgatgtc attgtggcca gagccggtgc gacaacgatt 1465621 gccgaaatta ctgctctcgg aatcccaagt gttctgatcc caagtccata tgtgacagcg 1465681 aatcaccagg aggtcaatgc gaggtctctt ggccagcatg atgcggcgat tgtactgaaa 1465741 gaaacagagc tcagcgggga gaagctgatt gaagcgctag accggattgt actgaatgag 1465801 caaacgttaa aggaaatgag cgaacgaaca aagtcactcg gtgttcctga cgcggctgcc 1465861 cgtttataca gcgtactcga ggaattaaaa aaatagtaga aaagcaaatg gaatgcggag 1465921 gtttacgatg gagaaagtga tacaggaatt aaaagaacga gaagtcggca aggttcttgc 1465981 aaatgaaccg ctcgcgaatc atacaacgat gaaaatcggc ggacctgcgg atgtattggt 1466041 cattccaagc agtgtggatg ctgttaaaga catcatggac gtgattaaaa aatatgatgt 1466101 gaagtggaca gtcatcggcc gcggatcaaa tcttcttgtt ttagatgaag gaattagagg 1466161 cgtagtgatc aagctggggg cgggtcttga ccatttggag cttgaagggg aacaagtaac 1466221 agtcggaggc ggttattcgg tggtccgcct tgctacatca ttgagcaaaa aaggcctgtc 1466281 cggtttggaa tttgctgccg gcattccagg atcagtcggc ggagcggttt atatgaatgc 1466341 cggcgctcac ggttctgata tgagcgagat cctcgtcaaa gcgcatattt tatttgaaga 1466401 cggaacgatt gagtggctga caaatgagca gatggatttc agctacagga catctgtact 1466461 gcaaaagaaa cgcccgggcg tttgccttga agctgttttg cagcttgagc agaaggataa 1466521 ggaatcaatc gttcagcaaa tgcaaagcaa taaagactat agaaaaaata cacagccgta 1466581 ttcaagccct tgtgcgggaa gcatattcag aaatccgctt ccgaatcatg ccgggaacct 1466641 tgtagaaaaa gcaggcttga aaggatatca aatcggcggt gcaaagatat cggagatgca 1466701 cggaaacttc atcgtcaatg cggggggagc atcagcaaaa gatgtgcttg atctcattga 1466761 ccatgtgaaa aagacaatcc gtgaaaaata cgagattgat atgcacacag aggttgaaat 1466821 catcggcgga aatcgctgat tcaagttctg actgaagctg ttcatatgat atactgtaag 1466881 caaacgacaa acggcatcat agtatgccgt ttgttttgga atagacagac ttttaacagc 1466941 tgtttcattt gaatgaggtg aacaggcaat gaacccgggt caagaccgag aaaaaatcgt 1467001 taacattgaa gagcggatcc ctaaaattaa agagcagagg aaacaaaagg caaaccgccg 1467061 tctcatttca tttattatgc tcttttttat tatggtgctg atcattgtgt acctgcaaac 1467121 accaatcagt aaagtatcaa caatctctgt tacagggaat gaaaatgtat caaaaaagga 1467181 aattatcgac ctttccgata ttaacagcgg agatactgag ttttggagtt tggacaagca 1467241 aaaaacagaa aagaagattc agcaaaataa attagtgaaa aaagcggaga tcagcaaatc 1467301 gcttcctaat aaaatcaaca ttgcaatcga agaatataaa gcgattgctt atttagaaaa 1467361 agacgatgtg tactatgaag tgcttgaaaa cggctcagtt ctgccaaacg aagtaacgcc 1467421 ggatgatgcc ggaccgattt tagtgaattg gacaaacgcg aagaagcggt ctcaaatggc 1467481 caagcagctc gatgcgttgt caaattcgtt aaaacagtcg atttcagaaa tttattatac 1467541 gcctgtaaaa atggatgaaa accgtattaa gttgtacatg aacgacggtt atgttgttac 1467601 ggcatctatt aaaacgtttg cagaccgaat gaagacgtat ccttctatca tctcacagct 1467661 aagcagcaat aaaaaaggaa tcattcattt agaagttgcc acctattttg aagagtttgg 1467721 gaaaaacgat aaagctgcta aaaaggaaga tgaaaattga ggggcaaatc agcagtcctt 1467781 ctttccttga ttatgcttat cgcaggtttt ttgatttcat tttcttttca aatgacaaaa 1467841 gaaaacaaca aaagcgcggc tgagacggaa gagtggaaaa aagaatatgc gctgagagat 1467901 gaactgctga aacaagagaa agaaaataag aagtttgaaa aagaattata tcaaaagcaa 1467961 aacaaagtcc gccaggcgga aaataagctg aagaaagaga agtcggaata ctataatgtc 1468021 ctcgaagata cagaaaaata caggatgtat attggggaag tcggtgtgca gggagaaggc 1468081 gttgaggtga cattggaaga tgcgtcatac ataccggaag gggagaatgt gaatagttac 1468141 atcgttcacg aaagccatat cttccaagta gtaaacgaac tgtatatctc aggagcggca 1468201 gctgtcgccg ttaatggaca gcgtttgacg catgattcgt atatcaaatg caatggtcct 1468261 gtggtaacgg tagacggggt gcagcatccc gctccgttta cggtatccgc tattggagat 1468321 ccagatgtcc tgctgccctc gttaaatatc gctggaggcc taattgatca gctgtcaatg 1468381 gatcatattt ctgtgtcggc agaaaaagag aaaaacgtac aaatgaaacc gattctgaaa 1468441 acgaaggaat gactgaaaaa gcgggtgaaa tagattgaaa ataaagcgtt ccttcataag 1468501 catcagtgtt cttatggtca tcttcggcct gatgatatct gttcagttta attcgttaaa 1468561 gcaccccaaa gtccgggata caagagatat gtgggatatt agggaagagc tgacatcaga 1468621 gcagaagaag caggaaaagc tgctggctga aataaacaaa tatgacaaat tgctgaatag 1468681 ctattcgcaa acgaaagaaa tgacaaaaga aaccgcgcta aataatacct tgcaatcctt 1468741 aaaaaaaaca gccggcatga ccgatataac aggtagcgga attgtcatta cgatttcccc 1468801 gcttttttct gaaagcttaa caggagagcc gatcgaaaat ccgcctccgg atttgctgaa 1468861 aaagctgata aatgaactca actcctacgg tgcagagcat atctcgatta atgagcgaag 1468921 agttgtgaat catacagtca tcagagatat aaacggcact acaaaaatag acggatacgc 1468981 ccttgacgat tatcctttaa cagtaaaagt gcttgccaaa gatccggaca tgttacacag 1469041 cagagtgaag gggtcaggcc ttgaggatct ttttgcatct gaaaatttag cattaaaagc 1469101 cggtaaatct gaaagcaaac taacattaaa agcatatgac agaccactgg acgtacaaca 1469161 gctgaaactg cttaaagact gaaaaggagg agaattgtca tgtggctgcc cgtgttggga 1469221 ctggtgctcg gaatagcgat tggactaatg acaaacttaa cgataccgag tgaatactca 1469281 aactatttat cgcttgcggt gcttgccgca cttgatacat taatcggcgg aatcagggcg 1469341 catttacaag gtacatatga tgaaatggta tttgtttccg gtttcttttt taatattata 1469401 ttggcaataa gtttagcttt tctgggagtc catcttggtg tagacttgta tttagcaggt 1469461 atattcgcat ttggagtcag attatttcag aatatagccg ttatcagaag aaatctacta 1469521 acaaagtgga ctctttctaa aaaaaataaa aaaaatgtga tataaaagag gatatacata 1469581 ggatataacg aatattttca ataaacataa aatgtgaaaa gcacataaaa atattctgtt 1469641 gttatttttt gttacacact tgtaaagcca cattcattgt attgttgttc cgcaaataat 1469701 agaatagaaa tgatcgaaat gtgaggaggt gccatagaat gaacaacaat gaactttacg 1469761 tcagtcttga catcggtacg tccaatacaa aagtgatcgt cggagaaatg acagatgatt 1469821 cccttaatat tatcggtgtg ggaaatgtac cgtctgaagg gttgaaaaaa ggctcaatcg 1469881 ttgatataga tgagaccgtt cattctataa gaaaagcgtt tgaccaagct gaaagaatgg 1469941 taggttttcc gcttagaaaa gctattgtcg gcgttaatgg aaattatatc aatattcaag 1470001 atacaaacgg tgttgtagca gtttccagtg aaaataaaga aattcaggtt gaagatgtac 1470061 gccgtgtcat ggaggcggca caggttgttt ccgtaccgca tgaacagctg attgttgacg 1470121 tcattcctaa acagtttatc gtagatggaa gagatgaaat caccgacccg aaaaaaatgc 1470181 tgggtgtgcg tttagaagta gagggcacct tgatcaccgg ttcaaaaaca atcttacata 1470241 acttactccg ctgcgttgaa agagctggta ttgaaataac tgatatttgc cttcagccgc 1470301 tggcagccgg ttctgctgca ttatcaaagg acgagaaaaa ccttggtgtg gctctcattg 1470361 atataggggg agggtcaaca accattgccg tattccagaa cggacatctc acttctaccc 1470421 gtgtcattcc tctcggaggc gaaaatatca ccaaagatat ctccatcgga ttgagaacgt 1470481 caacagaaga agcagaacgc gtgaaaaagc aacttggaca tgcctactat gacgaagcct 1470541 cggaagatga aatatttgag gtaaccgtta taggcaccaa tcaaaaacaa acatttacac 1470601 agcaagaagc agcgaatatc attgaagcga gagtagagga aattcttgaa attgtttcag 1470661 aagagcttcg cagtatggga attaccgatc tgccgggagg cttcgtgctg acaggaggac 1470721 aagcagctat gccgggtgtc atgtctttgg cacaggatgt gctgcaaaac aatgtcagag 1470781 tggcaagccc gaattatatc ggtgtaagag atcctcaata tatgacggga gtgggcctga 1470841 tccaattcgc ctgccggaat gcaagaatcc aaggcagaaa aataggcttt aagatgcctg 1470901 aagaagcgat acaggaaatc gcagtctcat catctgagga acaagagcag catcatcacc 1470961 aaaatgaggt gcagcagcgg ccaaaaggaa aacaaaaaac acaagccgaa cataataaac 1471021 agagcaaaat gaaaaaacta ttaagcatgt tttgggaata gatagatagt cattcggcag 1471081 attaggagga tttagcatgt tggagttcga aacaaacata gacggcttag catcaattaa 1471141 agtaatcgga gtaggaggcg gcggtaacaa cgccgttaac cgaatgattg aaaatgaagt 1471201 gcaaggagta gagtatatcg cggtaaacac ggacgctcaa gctcttaacc tgtcaaaagc 1471261 agaagtgaaa atgcaaatcg gcgcaaagct gactagagga ttgggagcag gtgcgaatcc 1471321 ggaagtcggg aaaaaagccg ctgaagaaag caaagagcag attgaagaag cacttaaagg 1471381 tgctgacatg gtattcgtga cagctggtat gggcggcgga acaggaacag gtgccgcacc 1471441 ggttatcgca caaatcgcga aagacttagg cgcattaaca gtcggcgttg tgacaagacc 1471501 gtttaccttc gaaggacgca aaagacagct tcaggctgca ggcggaatct cggcaatgaa 1471561 agaagcggtg gatacactga tcgtgatccc gaacgaccgt atccttgaaa ttgttgataa 1471621 aaacacaccg atgcttgaag cattccgcga agcggataac gtacttcgcc aaggggttca 1471681 aggtatttct gacttgattg ctacacctgg tcttatcaac cttgactttg ctgatgtgaa 1471741 aacaatcatg tcaaacaaag gatctgcttt gatgggtatc ggtattgcta ctggggaaaa 1471801 tcgcgcggca gaggcagcaa aaaaagcaat ttccagcccg cttcttgaag cggccattga 1471861 cggtgcgcaa ggcgtcctca tgaacatcac tggaggaaca aacctcagcc tatatgaggt 1471921 tcaggaagca gcagacattg tcgcttcggc gtctgatcaa gacgtaaaca tgattttcgg 1471981 ttctgttatt aatgaaaatc taaaagatga gattgtggtg acagtgattg caaccggctt 1472041 tatcgaacaa gagaaggacg tgacgaagcc tcagcgtcca agcttaaatc aaagcatcaa 1472101 aacacacaat caaagtgttc cgaagcgtga gccaaaacgt gaggaacctc agcagcagaa 1472161 cacagtaagc cgtcatactt cacagccggc tgatgatacg cttgacatcc cgacattctt 1472221 aagaaaccgt aataaacgcg gctaatgtaa aggacaaaat cgttttcgat tttgtccttt 1472281 tttgtttttc tcttcacact ttccttctta taaagtcttt ttccctattg cttccttcgc 1472341 gagctcgatt atggatggtt tacgttttgg aaaaagtaag gtatcctagt tcgtacaaag 1472401 ttttatgaaa attaaaacaa ttataaaagg caataaagag gaggaccacg atgattttgc 1472461 agcttgacaa tgtctcacta aaacggaatg ggaaatggat actgaaagat attcattgga 1472521 aggtggaaga aaaggaaaat tgggtgcttt acggcctaaa tggcgccggg aagacagcgc 1472581 tgttaaatat gctttgctca tattattttc caacatcagg cgagatgcag gtgctcggcc 1472641 atgaatttgg caaaacagag cttggggaaa agctcagacg taaaattggc ctcgtctcag 1472701 cagctcttca gcaaaaattg tatccggcag attcagcttt tgaaattgct ttgagcggag 1472761 cttacgcttc gattgggtta tatgaaacgc caagtaagga aaccagggaa aaagcgatag 1472821 gtttgttaga ggacttggga gcaattgaat atgccgatcg ccgctatgaa accctttctc 1472881 aaggggaaaa acaaagagca ttgattgcta gagcactaat ggccgatccg gagctgctga 1472941 tactggatga accagtcaca ggactggatt ttattgcccg ggaaaagctg ttagatacga 1473001 ttacatacat tgcaaacaaa gaaaatgcac catctatcct ttatgtgact catcatgctg 1473061 aagaaatttt gcctgtcttt gataaagccc ttttattaaa acagggagag gtttttggat 1473121 ccggagaaat aaaggaaatg cttactgatc aaatactttc cgcttttttt gatacgccaa 1473181 tccatgtatt atggaatcag gatcggccgt ttttaacaag agctgagccg ataacgaatg 1473241 cctgacaaat atatatagat tcatcctagg ggtgctttgc gaagctgaga gagactttgt 1473301 ctcaaccctt ttgacctgat ctggatcatg ccagcggagg gaagcggtga aaagcggagt 1473361 acatcggact ccgtttgttt ttattaagcc gtttcatcac atttgaaacg gcttttttga 1473421 ttttaaagaa taggagcgga tttacattgg atcaacaaat atactctttg caaaaaaaag 1473481 tggaagaaca taaggaggag cttattcagc ttgcgaaaac gctgatttct tatcaaacac 1473541 ctgctccgcc tgcaagaaat acagagggca ttcagtcttg gattgcggga tatttaaatg 1473601 aattgggatt ctcgatcgac aaatgggatg tgtaccctgg agatcccaat gttgtaggga 1473661 agctaaaagg aacagattca gcagattatt atagcctgat tatcaatggc catgtagatg 1473721 tggcagaggt aaaagaggat gaagaatgga agcacgatcc gtttcatccc attgaaaaaa 1473781 acggtctctt aatcgggcga ggcgcttccg atatgaaggg cggaatggct tgtgtgctgt 1473841 ttgctgtcaa attaattcgt gaagcaagca ttgaacttcc aggtgatctg attctgcaat 1473901 cggttattgg ggaggaagtt ggagaggccg gcacacttga atgctgcaag aggggctacc 1473961 acgctgattt tgcaattgtc gcggatacga gcgatatgca tattcaaggc caaggcggtg 1474021 tcattacagg ctggatcgaa atcaaaagca gtcaaacatt tcatgatgga acgagacgga 1474081 atatgattca tgcaggcgga ggaacattcg gagcaagcgc aattgaaaaa atggcaaaaa 1474141 tcattgcggg gctcggtgaa cttgagcgcc actggtctat tatgaaaagt tatcccggtt 1474201 ttaaaccagg cacaaatacg attaacccgg cagttataga aggcggcaga catgcggctt 1474261 ttatagcgga cgaatgccgg ctgtggatca cagtccattt ttatccgaat gaaacccatg 1474321 accaagtggc agcggaaata gaagattacg tcaatcggct gagtgacagt gatatttggc 1474381 ttagggaaaa ccgccctgta ttcaagtggg gaggctcatc tatgatagaa gacaggggag 1474441 aaatttttcc ggcattggaa gttgaccctg gccacccagg cgtcttagcg ctaactgcct 1474501 ctcatcagaa agtgaaacgg gagtgtccaa ttattgacgt ttctcaatca gttacagatg 1474561 gcggatggct gtatgatgcc ggtattccat gcgtaatata cggtcctgga gatctgcaca 1474621 atgcacactc tgtgaacgag aaggtatcga ttgagcagct agtagagtat acaaaaatta 1474681 tactcgattt tatcatcagc tggtgcagcc ggaaaaaaga acaatgacat gaaaatttct 1474741 tcttgctgac aaggttcagc ctgcccgttc atatacttga acaaaaggac ggaaaaagga 1474801 cgtgatggaa tgatcagcat ttcagaattt caggtaaagg atgtcgtcaa tgtctcaaac 1474861 ggaaaaaagc tggggagtat tggtgatatt gatatcaatg tgaccactgg aaaaattcag 1474921 gcgatcatac tcggaggaaa tgggaaagtt ctcggatttt ttggaaaaga agaggaattg 1474981 gtcattccat ggcgaaatat agtaaaaatc ggggaagatg taatcttagt ccgattaagt 1475041 gaaccacatg cataaacctg cttgtctgcc gcagattggc aaatgccgga agtctcgatt 1475101 cttccggcac atttcattta gaaatatgca aatcggcgct caacgaatgc agtaagatgt 1475161 ggtaaaataa gtgggaaatt ccgctttttt aaatgtttgt cgaaaggttg gatcatcatg 1475221 aatacatatc acccattcag tcttaccaca ccctcgacac tcatgataca agactgggct 1475281 caaacgaatc aaaacaacaa agaggtcatt gccggattta cgacaaaaaa cggcggtgtc 1475341 agccaaaagc cttttgaatc gttaaataca ggattgcacg ttcatgacaa agatgcagat 1475401 gtagttaaaa atcgtgaata tattgccgat atgtttaata ctgatttgca gtcttgggta 1475461 ttcgctgatc agacacatga taatcgcgtt cagaaagtga cgcagaggga taggggaaaa 1475521 ggcgcccgtg agtatcacac ggctctaaaa gcaacggacg ggatctatac aaatgaaaaa 1475581 aatgtatttt tagcattatg ctttgctgat tgtgtgcctc ttttctttta tgatccggtt 1475641 aagtcgcttg tcggagtcgc ccatgccggg tggaaaggca ccgtcaaaca gattggcaga 1475701 gaaatggtga agcaatggac tgagaaggaa ggttcaaatc cctcagatat ttacgctgtt 1475761 attggcccgt ctatcagcgg agcatgctat acggtagacg accgcgtcat ggatgctgtc 1475821 cgcgcattgc cggtttcagc agaccttgcc gccaatcaga cggcaaaggc acaatatcag 1475881 cttgatctga aagagctgaa ccgtcttata ctgatggaca gcggtttggc aagtgaacaa 1475941 atttctgtca gcggtttatg cacggaaagc gagccgtctc ttttctattc tcatcgccgc 1476001 gatcagggga aaactggacg gatgatgtcc tttatcggaa tgaaggaggc ataaaagatc 1476061 ttgcgtgttg ttgataattt acgacatata aacgaacgaa taaacgaagc atgtaacaga 1476121 tcgggccgca gctccgatga agttacggtt attgcagtca caaaatatgt atcacctgaa 1476181 agagcacagg aggcagtaga tgctggcatc acctgcctcg gagagaatcg ggatgcggaa 1476241 ctgctccgca aacaggaatt gatgaaaggg aatccggaat ggcattttat cggcagtctg 1476301 caatcaagaa aagcaaaatc tgtcgtcaat tcggtttcct atatccattc cctagaccgg 1476361 ctctcattag cgaaagaaat tgaaaaacgg gctgaaggta ctgtacgatg ctttgtgcag 1476421 gtcaatacct ctcttgagcc ttctaaacat ggcatgaaaa aagaagaagt cattccattc 1476481 atacaggagc tttccggttt cgaacatatc cttgttgccg ggctgatgac aatggctccg 1476541 ctgactgatg atcaagatca gatcagaagc tgtttcaggt cgctgagaga actccgtgac 1476601 caggttcaga agctgaacca gccgaacgct ccgtgtactg aactgtcgat gggcatgtca 1476661 aatgattttg aaattgcaat tgaagaagga gctacttata ttagaatcgg ctcatcgtta 1476721 gtcggaaatg aaacaggggg tgtacagcaa tgagtatgaa aaataaactg aaaaactttt 1476781 tctcaatgga agatgaagaa tacgaatatg aatatattga gacagagcgg gaatctcatg 1476841 aggagcatga gcaaaaagaa aagccggctt acaacgggaa taaacctgcg ggcaaacaga 1476901 atgtagtgag cttgcaaagt gttcagaaat cctctaaagt ggtgttgagt gagccgcgcg 1476961 tttatgcgga ggcgcaggaa atagccgacc atttgaagaa ccggcgggca gttgtcgtca 1477021 atcttcagcg gatacagcat gaccaggcga agcggattgt tgacttttta agcggaaccg 1477081 tttatgccat tggcggcgat attcaaagaa tcggctcaga tattttcctc tgcacgcctg 1477141 acaacgtaga tgtatcaggc acaatttctg agctcatatc tgaagacgaa catcagaggt 1477201 ggtaaagcga gatgatcctt tatcaagttt tttcggtttt aagcttatta atcacaatat 1477261 actcatttgc cctgatcata tatattttta tgtcatgggt gccgagtacg agggaaacag 1477321 cagtcgggcg ttttttggct tcgatttgtg aaccatatct cgaaccattc agaaaaatca 1477381 tccctccgat tgcaatgctg gatatttcac caatcgtagc aatacttgtg cttcggtttg 1477441 cgacaaccgg cttgtgggga ctttatcgca tgattgcgtt ttaatgtgac agtttgatag 1477501 gggcttggca gcagccaagc ctctttacat agaagggaaa gacgatgagc gatatatatc 1477561 agcacttcag aaaagacgag cgggccttta ttgatcaagc gctcgaatgg aaaagaattg 1477621 tccaggagca gtaccggatg aagctgaccg actttttaga tccccgagag caggtcatcc 1477681 tctctgctgt tacgggacag gcagatgtcg ggcttgcctt ttccggcggc tatgacagag 1477741 cggagcggaa acgggcgatt ctgtttccag agtacattac tccggaagaa tcagattttg 1477801 aactgcaggc gtttaacgtc cgttatgctg acaagtttgt ctcagtagat catcgttctc 1477861 tgcttggtgc attaatgggc ataggattaa agcggcaaaa attcggtgac atcgtgtttt 1477921 ctgagacagc agtgcaattg attgtctcag ccgataccgc tgattttgtg gctgcacagc 1477981 tgacccaagc aggcaaagcg gcggtcagcc tagagaaaat cgacttgtca gaccttaaca 1478041 ttccagcagt tgatgtcgaa ataagagatg acacggtttc ttctttaagg cttgacgccg 1478101 tctgcgcctc tatgagcagg caatcccgcc agaaatcaca gacgcttgtg aaaaacggcc 1478161 ttgtgaaagt gaactggaag gtggttgaag atccttcata catagtcgcg gaaggggaca 1478221 tgctgtctat cagaggtttt ggccggtgca gcttaacaaa aatcgaagga aaaaccaaaa 1478281 aagacaaatg gagagttacg tttgaacgac aaaaatagtc ggtttttcag tttttttctc 1478341 catctgtgcg aaatttgttt tataatgtga actagataac cgtactgaaa tgtaaaaatg 1478401 gaggtggcat catgccatta acgccaaatg atattcacaa caagacgttt acaaaaagtt 1478461 ttcgcggata tgatgaagat gaagtaaatg aattcctagc ccaagtcaga aaagattacg 1478521 aaattgttct ccgcaagaaa actgagcttg aagcgaaagt caatgagctt gatgaaagaa 1478581 tcggacactt tgccaatatt gaggagacat tgaataaatc aattttagtt gctcaagaag 1478641 cggctgaaga cgtaaaacgc aattctcaaa aagaagcaaa gctgatcgtt cgggaagcgg 1478701 agaaaaacgc tgatcgcatt atcaacgaat cgttatcaaa atcaagaaaa attgcaatgg 1478761 aaattgaaga gctgaaaaaa cagtctaaag tgttcagaac acgtttccaa atgctgattg 1478821 aagctcagct tgatcttctg aaaaatgacg attgggatca tctccttgag tatgaagtcg 1478881 acgctgtatt tgaggaaaag gaataaattc tctgattatc ttgacatttt cttagcttgt 1478941 cgaatataat acgttcataa attcagatga aaaaacggtt gaaagggaca gtcatgtttc 1479001 cttcaggcct tcatagcgac ccggagatgg tgagagtccg ggatggccgg aatcatgtag 1479061 atcagccctt tagtttcctt gctgaactca cagtaggtta ggacgttcat cacgttacga 1479121 tgctcaagag gaaaaagtgt atgcttgctt tttctaaaag ggtggtaccg cgagataagc 1479181 tttctcgtcc cttatgggat gagagggctt tttttatttt ctgaaaaaat gcagtggagg 1479241 aatgaaaatg gattttaaag acacgctctt aatgccgaaa acagatttcc cgatgcgtgg 1479301 aaatttgcca aaccgtgagc ctgacattca aaaaaaatgg gaggaagaag atatctaccg 1479361 tcttgttcag gaacggacga aagaccgccc gaaatttgtt ttacatgacg gacctccgta 1479421 tgcaaacggc gacatccata tgggccatgc acttaacaag attttgaaag acttcattgt 1479481 ccgctataaa tcaatgagcg gctacaacgc accgtatgtg ccgggctggg atacacacgg 1479541 attgccaatt gaaacagctc tgacaaaaaa caaaaaggtc aaccgcaaag aaatgtcagt 1479601 agcggaattc cgcaaactat gcgaagagta cgcttggaag caaatcgagg gacagcgtga 1479661 gcaattcaaa cgtcttggtg tccgcggtga ctgggaaaac ccatatgtga cattaaaacc 1479721 ggaatacgaa gcgcagcaaa tccgcgtatt tggtgaaatg gcaaaacgag gctacattta 1479781 caaaggcctt aaaccggtta actggtcacc ttcaagtgag tctgctctgg ctgaagccga 1479841 gatcgaatat caagataaac gttcagcatc tatttacgtc gcttttggtg taaaagacgg 1479901 aaaaggcgtt cttgaaaacg gcgagcgcat catcatttgg acaacaacgc cgtggacaat 1479961 tccggcgaac ctcggaatct cagtgcaccc tgatcttgag tacagcgtga ttgcagtagg 1480021 tgaagaccgc tttgttgtag caagtgcctt agtcgaaaat gttgcatcgg catgcggatt 1480081 tgatcagtat gaagtgacaa gaacggtcaa agggaaagac cttgagaaca ttatcgctga 1480141 acacccgcta tatggcagag actctctcgt tatgcttggt gaacacgtaa caactgatgc 1480201 cggaacaggc tgtgttcata cagcgcctgg acatggggaa gatgacttta tcatcggcca 1480261 aaaatacggt ttagatgtgc tttgcccggt cgatgaaaaa ggtgtaatga caagcgaagc 1480321 tcctggcttt gaaggcatgt tctatgatga tgcaaacaaa gcgatcacac agcagcttga 1480381 tgaaaaaggc gcacttgtga agcttgaatt cattactcat tcttatccgc atgattggag 1480441 aacaaaaaaa ccaaccattt tcagagcaac agcgcaatgg tttgcgtcta ttaaagattt 1480501 cagatcagac ctgctggatg ccattaaaga aaccaaatgg gttcctgaat ggggcgagca 1480561 gcgtttgcac aacatggttc gggaccgcgg agactggtgt atttccagac agcgtgcgtg 1480621 gggtgtgccg attccggtat tttacgctga aaacggagaa ccggttatta cagatgaaac 1480681 cattgaacat gtttctgaat tgttcagaca gcatggatca aacatttggt ttgaaaaaga 1480741 agcaaaggat cttcttccgg aaggctttac gcatcctggc agcccgaacg gcacatttac 1480801 aaaagaacag gatatcatgg atgtttggtt tgattcaggc tcttcacatc aagcagtgct 1480861 tgaagaacgt gatgacctcg ttcgcccggc tgatctatac ctagagggat ctgaccaata 1480921 tcgcggctgg tttaactctt ctctttctac agcagtagcc gtaacaggga aagcgccgta 1480981 taaaggtgtg ctcagccatg ggttcgcact ggatggagaa ggacgtaaga tgagtaaatc 1481041 aatcggtaac gttgttgttc cggctaaagt catgaaacag cttggtgccg acatcttaag 1481101 attatgggta tcttcagtgg attatcaggc ggacgttcgc gtgtctgacg ccattctgaa 1481161 gcaggttgcg gaagtatatc gtaaaatccg caacacgttc cgtttccttc acggcaacct 1481221 tttcgatttt gatccaaaaa caaatgcggt ggctgtcgaa gatcttcgcg aagtggatca 1481281 gtatatgctg attaagctga acaagctgat tgataaagtg aaaaaagcgt atgatgagta 1481341 cgaatttgcg gttgtgtatc acagcattca taatttctgc acaatcgaat tgagctcatt 1481401 ctaccttgat tttgcaaaag atattgtcta catcgagcat gcggatcatc cggatagacg 1481461 cagcatgcag acagtattct acgaaacgct tcttgcatta gtgaagcttt cagcgcctat 1481521 ccttccacat acggcagacg aattgtggtc tcatttaaca tttgttgaag agcagagcgt 1481581 tcagttgacc gatatgccgg aaacaatcac ggttccaaac agtgaagcga ctgaagaaaa 1481641 atttgaccgc tttatggctc ttcgtgatga cgtgttaaaa gcattagaaa ctgcgcgaaa 1481701 tgaaaaaatt atcggtaaat ctttggaagc aaacctgaaa ttgtatccaa acaaagaaaa 1481761 caaggagctc ttggcttcca taaaagaaaa cctttctcag ctgtttattg tgtctgaact 1481821 gacaatcagc gaagaaaatg aagcgccgaa cgatgcgcaa agctttgcga cgggtaaaat 1481881 cgctgtcgag aaagcggaag gcgaaatgtg tgagagatct cgtgtgattt caaaagatgt 1481941 aggggcaaat ccgaaatatc ctacactttc attacgcaac gctgaaatcg ttgaaaaata 1482001 ctatcaaaaa taatgcaaaa gagcccggcg taaaagccgg gctttttttg tgccaagagt 1482061 gacatccttt agaacgaaag gaaaaatctt atgggcttta gatcatcatt cacaggcaac 1482121 aataaagata ctacgttaag agcaggagtt gtgaagaatg aatgatcaac tgaccgcaat 1482181 ttatacggaa cttcttctga tgaaagaaga attacagtcg agattatttg agtattcttg 1482241 ctttcaggtt tctacaagcc cgcaagcagc aatcaatcaa aaacaaaaag caactctgat 1482301 ctatcatatt aaagaagaac ttcaagacgt tctccttgca ttgtccaaaa tcgaaaacgg 1482361 cacattcgga tactgtgaag aaactggggc ccccattcct cttgcaaagc tggcagtgct 1482421 gccgacggcc cgaacagcaa acgattttct ttattctgtc caatttgaga aaaaaacgct 1482481 tccgatatgg aaatcaacgg atatcgaata tggtcaggca ctgtatgaat aacagtgtct 1482541 gtccggttaa tatgcctgat atttctttac tccagtgctt tttattgata aaatgcataa 1482601 tggattaaag taaccgtaaa ctggaggaac gtttgtgctg tattatatga ttgcactact 1482661 tattattgca gccgatcaat tgacaaaatg gctagttgtt aagaacatgg aacttggcca 1482721 aagcattccg atcattgatc aggtattcta tatcacctcc catcgcaata cgggtgctgc 1482781 atgggggata ttagcgggtc aaatgtggtt tttctacctc ataacaaccg ctgttattat 1482841 tggtattgtt tattacatac agcgttatac aaagggacaa aggcttcttg gcgttgccct 1482901 cggacttatg cttggcggtg ccatcggcaa ctttatcgat cgggctgtca gacaggaagt 1482961 tgtggatttt atccatgtta ttattgtcaa ttacaattac ccgatattta acatcgcgga 1483021 ctcttcacta tgtgtcggcg taatgctttt atttatacaa atgctgttgg acagcgggaa 1483081 aaagaaaaag gagcaatagc atgaatcaaa ttgatataac cgcttcagaa gaacaaaaaa 1483141 gtgagcggat tgataaattt ttggcatcga ctgagaatga ttggtcaaga acccaggttc 1483201 agcaatgggt aaaagacgga caggttgtcg tgaacggaag cgcggtgaaa gcgaattata 1483261 aaattcagcc gggtgatcag gtgaccgtca ctgtacctga accggaagcg ctcgacgtcc 1483321 tggcagagcc tatggatctg gatatttatt atgaggacca ggatgtgctg gtcgtcaaca 1483381 aacctcgcgg aatggttgtt cacccagcac ccgggcatct tacgggcaca cttgtaaacg 1483441 gtcttatggc tcattgcaca gacctttccg gaataaatgg tgtgatgcgc ccgggtattg 1483501 ttcacagaat cgataaggac acgtccggtt tattaatggt ggcgaaaaat gatatggcgc 1483561 acgagtcact cgtaaaccaa ttggtcaaca aaacggtcac gcggaaatat acggcggttg 1483621 tccacgggct tatttctcat gatgacggca caattgacgc gccgatcgga cgggataaaa 1483681 aagaccgtca aagcatgact gtgacacgtg atggcaaaaa cgctgtcact cattttcatg 1483741 tgcttgagcg ttttcaggat tttacgttag tggagtgcca gcttgaaaca gggagaaccc 1483801 atcaaattcg tgttcatatg aaatatatcg gattcccatt agcaggcgat ccgaaatacg 1483861 gcccaagaaa aacaatcgac tttaatggcc aagcgcttca cgcgggagtt ttaggttttg 1483921 accatccacg aacaggagaa tatgtcgaat ttgaagcgcc gcttcccgag gatatggcag 1483981 aattaatcga aaacctcaga aaaaacggtt gacagagggt ttcttttctg aaataataaa 1484041 cgaagctgaa tagattcttt aaaacagtcc agagaggctg agaaggataa cggatagacg 1484101 ggatgcgtgt ataggcgcgc accttgtcct aaaacccctc tatgctctgg caggaggggt 1484161 tttttcttct atatgaactg tgaggtgtca cacattgaat caaaaagctg tcattctcga 1484221 cgaacaggca attagacggg cgctgaccag gattgctcac gaaatgatcg aacgcaataa 1484281 aggaatgaat aactgcattc ttgtcggcat taagacaaga gggatttacc tggcaaaacg 1484341 ccttgcggaa cgcattgaac agattgaggg aaatcctgtt acagtcggtg aaattgatat 1484401 tactctttac agagatgatc tttctaaaaa aacaagcaac gatgaaccgc ttgtaaaagg 1484461 tgcagatatt ccggtagata ttacagatca aaaagtcatt ctcgttgatg atgttctgta 1484521 taccggaaga acagtcagag caggaatgga tgcgcttgtt gatgtaggca gaccttcctc 1484581 cattcagctt gcagtgcttg tggacagagg acaccgggag ctgccgatcc gagcggatta 1484641 tatcgggaaa aacatcccga catcaaagtc tgaaaaggtt atggtacagc ttgatgaggt 1484701 agaccaaaac gatctcgtcg ccatttatga aaacgaataa tagatcacct ttttaagggc 1484761 aatccagaga ggttgcaaag aggtgcacaa caaaggccca aaaagtattc ggcaggtctt 1484821 tgtatgcctc tttgcgtaaa aaagcaaaga ggttttttta tacagtcatt gagtcatcct 1484881 aaaatgaaag tcaacaatca gggggaaatc atcatgagta agaaaaaagt aaatttaggg 1484941 gtcagggatg tcccgacacc tttctcttgg gtttcattca gccttcagca tttgtttgcc 1485001 atgtttggct caaccatttt ggttccgaag ctcgtcggaa tgagtcctgc tgtggcgttg 1485061 gtgacaagcg gcatcggaac actggcgtac cttcttatta ccaaaggaca aattccggcg 1485121 tatctcggtt catccttcgc ctttatttct ccgatcattc tggtaaaagc gaccggcggg 1485181 ccgggagcgg caatggttgg agcgtttctt gcagggctgg tgtacgggct gattgcctta 1485241 ttgattaggc agcttggaac aggatggctg atgaagattc tcccgcctgt agtcgtaggg 1485301 cctgttatta tcgtcatcgg gctgggactg gcaagcactg cagtaaacat ggcgatgtat 1485361 gctgatccga acgcgagtga gttggtctac agcttaaagc actttagtgt cgcaggagtt 1485421 acgctggcaa ttacgattat ttgtgcgatt ttcttacgag ggtttttaag cctgattccg 1485481 gttctgatcg gaatcatcgg cggatacctg tttgccctta ctcaagggat tgtcaacttc 1485541 cagccggtgc ttgacgcgaa atggtttgca gtgcctgaat ttatcattcc gttcaaagat 1485601 tattcaccgt cagttacgct cggcatcgca gccgcaatgg ttcctgtcgc atttgtcaca 1485661 atgtcagagc atatcggcca ccaaatggtg ctgagcaagg ttgtcggaca agacttcatt 1485721 aaaaagccag gtcttcatcg ctctattatg ggtgacagtg tggcgacaat cctcgcttcc 1485781 ctgatcggcg gccctccgac aacgacttac ggagaaaaca ttggcgtgct ggccatcaca 1485841 agagtattca gcgtctttgt catcgggggc gcggcagtga ttgccctttg cttcggcttt 1485901 atcggcaaaa tttcagcgct gatcagttca gtgccgtcag cggtcatggg aggcgtctcc 1485961 ttcctgctgt tcggaatcat tgcttcaagc ggcctgagaa tgctgattga caacaaaatt 1486021 gattatgaaa acaacagaaa cctcattatt acatcagtta tccttgtcat cggtgtagga 1486081 ggcgctttta tccaagtgtc tcagggcgga ttccaagtgt caggaatggc gcttgccgca 1486141 attgtcggtg tcatcttaaa cctgattctt ccgcaggcga aggaagagca ggcagacaca 1486201 tctgaacaac atcatattta aaacctttta atgaaagtcc agagaggctt ggaagggtta 1486261 tgaagagaag gaagcttcaa tgctgccctc tatttaacca taccccgagt ctatcttaga 1486321 ccggggtttt ttttcagcct taagttgaaa agagagggga aagaacatga agcatttaac 1486381 gacgatgagt gaacttagca ctgaggaaat caaagatttg cttcaaacag cacaagagct 1486441 caaaagcgga aaaacagaca atcagcttac aggaaagttt gcagcaaacc tgtttttcga 1486501 accgagcacg agaacgcggt tcagctttga ggtcgcagaa aaaaagctgg gcatgaatgt 1486561 gcttaacctt gatggaacaa gcacaagcgt gcaaaaaggc gaaaccttat atgacacgat 1486621 ccggacgctt gaatcaatcg gtgtggacgt ctgcgtcatc aggcacagtg aggatgagta 1486681 ttatgaagag cttgtcagcc aggtgaacat tccgattctg aatgcgggag acgggtgcgg 1486741 ccagcatcca acacaatcac tgcttgattt aatgacgatt tatgaagagt tcaatacgtt 1486801 taaagggctt accgtctcca ttcacggcga catcaagcat agcagagtgg caaggtcaaa 1486861 tgcggaagtg ttgacaagat tgggtgcccg ggtcctattt tccggccctt cggaatggca 1486921 ggatgaagaa aatacattcg gcacgtatgt ctcaatggat gaagcagttg agtcttccga 1486981 tgttgtcatg ctgctgcgca ttcaaaatga acgacatcag tccgctgtca gtcaggaagg 1487041 ctatttaaac aaatacggct tgaccgtaga acgggctgag cgtatgaagc ggcatgcgat 1487101 catcatgcat cctgctccgg taaacagagg agtggagatt gatgacagct tagtagaaag 1487161 cgaaaaatca agaatcttca agcaaatgaa aaatggcgta tttatcagaa tggcagtgat 1487221 acagcgtgcc ttacaaacca atgtgaaaag aggagaagca gcgtatgtca tatctcatta 1487281 aaaacggctg gatactaaac gaaaatggtg aaaaaacaca agcggatatc cgagtgactg 1487341 gagaaaccat caccgcaatc ggcaagcttg atgcaacgga taatgaaacg gtaattgatg 1487401 caaaaggttt gctcgtttca cctgggtttg ttgatctcca cgtgcatttc agagagccgg 1487461 gcggagagaa aaaagaaact attgaaaccg gggcaaaagc agcggcgcgc ggcggctata 1487521 ctacagtagc agcaatgccg aatacgcggc cggttcctga tacaaaggag cagatggaat 1487581 gggtgcaaaa cagaattaaa gaaacatcat gcgtaagagt tcttccatat gcatccatta 1487641 cgatcagaca aatcggcgat gaaatgacaa actttgaagc gttaaaagaa gccggggcat 1487701 ttgcttttac agatgacggc gttggtatac agacagcagg aatgatgtat gaagcgatga 1487761 aacgggcagc cgcaattgac aaagcgattg ttgcacattg cgaggacaac tccttaattt 1487821 acggagggag cgtacatgag gggacattct ccaaagcgaa cgggctaaac ggcattcctt 1487881 ctgtgtgtga atcggttcat attgctcgcg atgtgctgct ggctgaggcg gcaaactgcc 1487941 attatcatgt atgccatatc agcacaaaag aatctgtcag agttgtacgc gatgcgaaaa 1488001 aagcgggaat cagagtgaca gcagaagtat cgccgcatca tttgctgctt tgtgatgagg 1488061 acatcccggg gctggacaca aactataaaa tgaatcctcc gctccgcagc ccagaagaca 1488121 gagctgcttt aattgaaggt cttttagacg gaacaattga ttttatcgca acagaccatg 1488181 caccgcatac ggaagaagag aagaacacag aaatgaagct ggcgccattc ggaattgtcg 1488241 gcttagaaac agcattcccg cttctttaca cacactttgt caaaaatggc agctggtcac 1488301 tgaagcagct gattgactac atgacaatca agccatgcga agcgttcggt ctcccatatg 1488361 gaacattaca aacggggcaa gctgcggaca ttacgttaat cgatttagaa aaagaagcag 1488421 ttatagacaa agagacattt ttatcaaaag gaaaaaatac accattcaac ggcatcagtt 1488481 gcaccggctg gccggtcgct acaattgcgg cagggaagct tgcttatgaa gaggggagac 1488541 ttgtcaaatg aagagacgat tagtactgga aaacggagcg gtattcgagg gagaagcttt 1488601 cggaagctta gaacacaaca tgggagaagt cgtttttaat actgggatga caggctatca 1488661 ggaaatttta tctgatcctt cttactgcgg acagatcgta acattaacat acccgcttat 1488721 cggaaattac ggcattaacc gtgatgattt tgaatccatt accccttttg tcaaagggct 1488781 gatcatcaaa gaattatgtg agctgccttc caactggcgt tcagcataca ccttagacga 1488841 gtatttaaaa atgaaaaaca ttcccggact ccagggaatt gatacaagga agctgacaag 1488901 aatgatccgc acggcaggcg cgctaaaagg aacattcgct tcatctgatg aagatatcga 1488961 agcagtgctg aaaagactga acgaaacgga attgccaaga aatcaagtat cccaagtatc 1489021 agcaaaaaca gcatatccga gcccgggaag aggcaaacgc attgtcttgg ttgacttcgg 1489081 catgaaacac gggattctaa gagagctgaa caaacggaaa tgtgacgtca tcgttgtgcc 1489141 ttacaacatt acagcggaag aggtgcttca gctgaaaccg gacggtatca tgctttctaa 1489201 cggacctgga gacccgaagg atgtgcctga agcgattgaa atgattaaag gtgttcttgg 1489261 aaaagtgcca ttattcggaa tatgtctcgg ccaccaatta ttcgcgctgg cgtgcggggc 1489321 gaatactgaa aaaatgaaat tcggccacag gggctcaaac cacccggtaa aagagctggc 1489381 tacaggaaaa gttgccttaa catctcaaaa ccatggatat acagtttcgt ctatcagtaa 1489441 aacagaactg gaagtgacgc atatcgcaat taacgacgat acgattgaag ggctgaagca 1489501 taaaacattg ccggcattta cggttcaata tcatcccgaa gcctcacctg gtcctgagga 1489561 tgccaaccat ctatttgaca gattcatcga aatgatcgaa acaacagaga aagaagggga 1489621 agcggtatgc caaaacgcgt agacattaac aaaattttag taatcggatc tggaccgatc 1489681 atcatcggcc aagcagcaga atttgactat gcgggaacac aagcctgtct tgctttgaaa 1489741 gaagaaggct atgaagtcat ccttgtcaac tcaaaccctg caacgatcat gacagataca 1489801 gaaatggctg accgggttta catcgaaccg ctcacacctg aattcctgac acgaatcatc 1489861 agaaaagagc gcccggatgc cattcttcct acactcggag gccaaaccgg tttgaatctt 1489921 gcggttgagc tttctgaaag aggcgttttg gcagaatgcg gcgtcgaagt gcttggcacg 1489981 aaactgtctg cgattcagca agctgaagac cgtgacttgt tcagaacatt aatgaatgaa 1490041 ctgaatgaac cggtgcctga aagtgagatt atccactccc ttgaagaagc agaaaaattc 1490101 gtcagtcaaa ttggattccc tgtcattgtc cgcccggcat atacattagg cggaacaggc 1490161 ggaggcatct gctcgaatga aacagagcta aaagaaatcg ttgagaacgg cttgaaatta 1490221 agcccggtac accaatgtct gcttgaaaaa agcatcgccg gctataaaga aatcgagtat 1490281 gaagtcatga gagacagcca ggatcacgcc attgtcgttt gtaacatgga aaacattgat 1490341 ccagttggaa tccatactgg agacagtatt gttgtcgcgc cgagccaaac gctcagcgat 1490401 cgcgaatatc agctcttgcg gaatgtatcg ttaaaactga ttcgcgcgct tgggatcgaa 1490461 ggcggatgta atgtccagct cgccttagat ccagacagct tccaatatta cattattgaa 1490521 gtaaatccgc gtgtcagccg ttcatctgcc cttgcatcaa aagcaacggg gtacccgatt 1490581 gcaaagctcg ctgctaaaat tgcagtcgga ctttcattag atgaaatgat gaacccggtg 1490641 acaggaaaaa catatgcagc atttgaacct gctcttgact atgtcgtatc caaaattccg 1490701 cgctggccgt ttgataagtt tgaatcagca aacagaaagc ttggcacgca aatgaaagcg 1490761 acaggtgagg tcatggcaat cggccgcacg cttgaagagt cattgctgaa ggcagtgcga 1490821 tcactggaag cggatgtgta tcatcttgaa ttgaaggacg ccgctgacat ttcagatgag 1490881 cttcttgaaa agcgaattaa aaaggccggt gatgaacgct tattctactt agctgaagcg 1490941 tacagaagag gctacacggt agaagacctc catgaatttt ccgctatcga tgtcttcttc 1491001 ttgcataagc tgttcggaat cgtacagttt gaaaaagaat tgaaggccaa tgcgggcgat 1491061 acagatgtgc tgagacgggc aaaagaactc ggcttctctg atcagtacat cagccgtgaa 1491121 tggaaaatga aagaatctga gctttacagc ttgagaaaac aagcggggat tgcgccggta 1491181 ttcaaaatgg tagatacatg cgcggcggaa tttgagtcag aaacgccata cttctatagc 1491241 acatatgaag aagaaaatga atctgtcgtt acagataaga aaagtgtgat ggtgcttggt 1491301 tcgggtccga ttcgaatcgg tcagggtgtc gagttcgact atgcgacggt tcactctgta 1491361 tgggcaatta aacaagcagg ctatgaagcc attattgtca acaacaaccc ggaaaccgtt 1491421 tcaacagact tcagcatctc agacaagctg tattttgaac cgcttacgat tgaagatgtc 1491481 atgcacatca ttgacctcga acagccaatg ggcgttgtcg tacaatttgg cggacaaact 1491541 gcgattaacc ttgctgacga gctttctgca cgcggagtga aaatccttgg aacttcatta 1491601 gaagatttag accgtgccga agaccgggat aaatttgaac aagcgcttgg agaacttggt 1491661 gttcctcagc cgcttggcaa aacagcgaca tcagttaatc aggcggtaag catcgcaagt 1491721 gatatcggtt atccggtact ggtacgccct tcctatgtac ttggcggccg ggcgatggag 1491781 attgtttacc atgaagagga actgcttcat tacatgaaaa atgcagtcaa aatcaatcca 1491841 cagcaccctg tattaattga tagatacttg accggaaaag aaattgaagt cgatgcagta 1491901 tccgacggtg aaacagtcgt cattccggga attatggagc acattgaacg tgcgggcgtt 1491961 cactccggag actcaatcgc tgtttatccg cctcagtctc tcacagagga cattaagaaa 1492021 aaaattgaac aatacacgat cgcattggct aaagggctga atattgtcgg tttgctcaat 1492081 attcaattcg tcttgtcgca aggcgaggtg tacgtgctag aagtgaatcc gagatcaagc 1492141 agaaccgtac cgtttttaag caaaattacg ggtatcccaa tggcgaatct cgcaacaaaa 1492201 atcattcttg gtcaaaagct ggctgcgttt ggctatacag agggccttca gcctgaacag 1492261 caaggtgtat ttgtaaaagc gccggtcttc tcctttgcca agctgagaag agtggatatt 1492321 acgttagggc ctgaaatgaa atcaacaggt gaagtcatgg ggaaagattc gacacttgaa 1492381 aaggcgctct acaaagcctt gatcgcttca ggtattcaaa tcccgaacta cggttccgtg 1492441 cttttaacag tagctgataa ggacaaagaa gaagggcttg ccattgctaa gcggttccac 1492501 gcgatcggct acaacatttt agcgacggaa ggaacggcag gctacctgaa agaagcttcc 1492561 attccagcga aggtcgtcgg aaaaatcggt caggatggcc cgaacttgct tgatgtcatc 1492621 agaaacggag aagcgcagtt tgtcatcaat acgctgacaa aaggaaagca gccggcaaga 1492681 gacggtttta gaatcagacg tgaatcagta gaaaatggtg ttgcctgcct aacatcttta 1492741 gatacggcag aggcgatatt gcgagtgctg gaaagcatga cattccgtgc tgatcaaatg 1492801 ccggcagtca acacaaatca ggaggcggca gtcactatat gaaaaaagcg tatttgacag 1492861 tatgttctaa ccagcaaatt gcagaccggg tgtttcaaat ggttctgaaa ggggagcttg 1492921 tccaagggtt tacaacccct ggacagttcc ttcatcttaa agtgagcgaa gcggttacgc 1492981 ctcttttgag aaggccgatc agcatcgcag acgtcaactt tgaaaaaaat gaagtcacca 1493041 tcatttatcg ggtagatggg gaagggacaa gactcttgtc actgaagcag cagggagaac 1493101 ttgtggatgt cctcgggcct ttgggaaatg gctttcctgt taatgaagtt caacccggaa 1493161 agacggcttt gctggtagga ggcggagtag gtgtgccgcc tctccaagag ctgtcgaaac 1493221 gcttgattga aaaaggggta aatgtcatcc acgttttagg attccaatcg gcaaaggatg 1493281 ttttttacga ggaagaatgc cggcagtacg gagacacgta tgtggcaaca gctgacggaa 1493341 gctacgggga aaccggattt gtcacagatg tgattaaacg gaaaaagcta gagtttgata 1493401 tcctcctcag ctgcgggccg acaccgatgc tcaaggcgtt aaaacaggaa tatgcccata 1493461 aagaagtata tctgtccatg gaggaacgaa tgggctgcgg aatcggcgca tgcttcgcgt 1493521 gtgtgtgcca tacaaacgaa agtgagacat cctatgtaaa agtatgtctc gacgggcctg 1493581 tatttaaagc tcaggaggtg gcgctgtaat gctagaggtg aaattgccgg gacttgattt 1493641 gaaaaaccca atcattcctg catcaggctg cttcggtttt ggaaaagaat tttcacgttt 1493701 ttatgatttg tcttgtcttg gagctatcat gattaaggct acgacaaagg agccgcgctt 1493761 tgggaatccg acgccgcggg tagctgagac tggtgctgga atgctcaatg cgatcggtct 1493821 ccaaaatccg gggctggata gtgtgttgca tcatgagctg ccgtggcttg agcagtttga 1493881 tacaccgatc attgccaatg tcgcaggttc tcaagtcgat gattatgttg aagtcgcaga 1493941 acatatcagc aaagcgccta atgttcatgc tcttgaattg aatatttcct gcccgaatgt 1494001 gaaaacaggc ggaatcgctt ttggcacgaa tcctgaaatg gctgccgatt tgacaaaagc 1494061 ggtgaaagag gtttcggatg tacccgttta tgtgaagcta tccccgaacg tggctaatat 1494121 cacagaaatt gcattagcga tcgaggaagc gggagcggac ggtcttacga tgatcaacac 1494181 actaatcggc atgagactcg atttaaaaac cggcaaaccg atattagcga ataaaacagg 1494241 gggactttcg ggccctgctg tgaagccggt tgccattcgc atggtgtatg aagtcagcca 1494301 gatggtcaac atcccgatta tcggaatggg aggcgtgcaa acggctgaag atgccctgga 1494361 atttcttctc gcgggagcaa gcgcagtcgc tgtcggaaca gcaaactttg tgaatccttt 1494421 tgcatgtcca gagattattg aacagctccc atctgttttg ctccaatacg gctatcaatc 1494481 aattgaagaa tgcatcggaa ggagctggaa tcatgaaaaa caacctgccc atcatcgcgc 1494541 ttgattttgc gtcagctgaa gaaacacttg cgttcttagc gccttttcag caagaaccgt 1494601 tatttgtaaa ggttgggatg gagctttttt atcaagaagg gccatctatc gtgaaacaac 1494661 taaaagaaag aaactgcgag ctatttttag atctaaagct tcatgacatc ccgactactg 1494721 taaacaaagc gatgaagcgc cttgccagtc ttggagtaga cctcgtcaat gttcatgctg 1494781 ccgggggcaa aaaaatgatg caggcagctc tcgaaggctt agaagaaggt acgccggctg 1494841 gaaaaaaacg tccgtcactt atcgcggtaa cccagctgac aagcacatct gaacaaatca 1494901 tgaaagatga actgctgatc gaaaagtctc tgattgatac ggttgtgcac tacagcaaac 1494961 aggcggaaga aagcggactg gatggagtgg tctgctctgt tcatgaagca aaagccattt 1495021 accaagcggt gtcgccttca tttctgactg tcactccggg gatcagaatg tcagaggacg 1495081 ctgcgaatga ccaagttcgc gtagcgacgc ctgccattgc aagagagaaa ggttcatcag 1495141 cgattgtagt aggacgctcg attacaaaag cggaagaccc ggtaaaagcc tataaggctg 1495201 tcagacttga atgggaggga atcaaatctt gaaacaaatc atcgcaaaac atctattaga 1495261 catccaagct gtatttttac gcccgaacga gccgttcaca tgggcaagcg gcattttatc 1495321 accgatctac tgtgacaacc gccttacgct atctttccca gaggtcagaa acgatgttgc 1495381 ttcaggtatc agcaagcttg ttaaagagca ttttcctgaa gctgaaatga ttgcgggaac 1495441 agcaactgcc ggtattcctc atgctgctct tgcggcggac catttgaatc ttccgatgtg 1495501 ttatgtgagg agcaagccga aggcgcacgg aaaaggcaat cagattgagg gagctgtgca 1495561 agaagggcaa aaaacagtcg tcattgaaga cttaatttcc acaggaggca gcgtgcttga 1495621 agcttgtgca gctttacaag cggccggctg tgaagtgctt ggtgtcgtct caatctttac 1495681 gtacggactt cctaaagcgg aggaagcctt cgcaaaggca gaactgccat actactcatt 1495741 aaccgattat gatacgctca cagaggtcgc gcttgaaaac ggaaatattc attcagatga 1495801 tctaaaaaag ctgcaaacat ggaaacgaaa tcccgagtca aaagattggt ttaaaaaata 1495861 aaaaataaat tcaaatgatg taaagaggct tcaaagcctt gctgtacttg aaaacaggct 1495921 gtgaggcctg tttttttatt aatcctataa aaaaagtcgg gttgacttat gttagaattg 1495981 tgctaaaatt tactacaaat ctaaaaactt atcaagagcg gctgagggac tggacctatg 1496041 aagcccggca acctgcatag tttgtaaggt gctacttcca gcaaaatgaa ttccattttg 1496101 aaagataagg gctgcatgct gttcctgtct ttctttccgc cggattgaaa gttttttatt 1496161 ttaagaggta aaaaggctat ctgtatatca gcagccgcga atcacattac atgggaaaag 1496221 acaaccggca gaaagctact gtttgtttgt ctccgaaagg aggaaagaag aaatgttaac 1496281 gtatgataat tgggaagaac caacgattac atttccggaa gacgatcctt ataaaggagc 1496341 gctgtcagtt ttaaaatggg catacggcca ttacggcgat cagcttgttt atgcctgcag 1496401 tttcggaatt gagggaatcg ttctgattga cttaatttat aaagtgaaaa aagacgcaga 1496461 gattgtgttt cttgatacag gacttcattt taaagaaacc tatgaaacaa ttgaacgagt 1496521 gaaagagcgt tatccgggtc ttaatatcat cctgaaaaaa ccagatctca cccttgagga 1496581 acaagccgaa gaacatggtg acaaactatg ggaaagagag ccgaatcagt gctgctatct 1496641 tagaaaggtc gttcctttaa gagaggcgct ttcaggacat ccagcctggc tttccggcct 1496701 gcgccgtgat caagggccaa gccgtgccaa tacgaatttc ttaaacaaag atgaaaaatt 1496761 caagtcagta aaagtttgcc cgcttatcca ttggacttgg aaagacattt ggagatatac 1496821 atcccggaat gaactggact acaatccgct tcatgaccaa ggctatccaa gtattggctg 1496881 tgcgccttgc acttctcccg cttttacagc agaagatttg cgctcaggca gatggaatgg 1496941 tatggcgaaa acagaatgcg gactgcatga ataaggagct gcaaaatgga attagccgct 1497001 attttattta gcttgttttt cgcgatgaat attggtgcaa gcggcgctgc agcttcgatg 1497061 ggggttgctt acggctccgg agccatcaaa aagaaaactt acgctttgat cctatgcgca 1497121 gtcggtgtct ttgccggggc ggtcattggc ggaggcgagg ttgtaaaaac aatcagctcc 1497181 ggcattattc ctgagcagac gattacactg acgattgttt gcatcattat tggagctgct 1497241 gccctgtcgc tctttactgc taatctgctc ggcattcctt tgtcgacaag tgaagtaaca 1497301 gtcggcgcgg ttgtcggcgt gggagtggct tataaagtat tgtttgtgaa caatcttctg 1497361 atcattgtgt cattttgggt ttttgtcccg ctgttcgctt tcggcttcac ctatttcgta 1497421 tctaagctgt ttcgttattt taagattgaa gtaaaatctt ctaaaaagca aaaaatcctc 1497481 ggcattgttt tgttagttgc cggatttttc gaagcattct ctgccggcat gaataacgtg 1497541 gcgaatgctg ttggcccgtt agtagctgcc ggtgtgcttg atgtcggaaa aggaaccttg 1497601 tatggaggag cttttgttgc tcttggcgca ctgttattag gccggcgagt gctagaaaca 1497661 aacgggaaga aaattacgag gttctccaaa ggggaaggca ttctcttatc cggtacagga 1497721 gcgggactgg tgatcatcag ttctgtattt gggatgccgg tgcccttggc gcaagtcacg 1497781 tcatcgtcta ttatcggaat aggcatggcg aaaaacggtc cgaacgtgtt ccataaacaa 1497841 gttgttcaaa cgatgctgaa ggtatggatc gtatcgccgt ttttatcttt atcgatttct 1497901 tatctgcttg tatccttgtt tttaaaagca gattattatt cgatctttat catggtaagt 1497961 gtgcttttag cggcgggcgg tgccatcagc ctgacaaagg ccattcgtaa agagagacgc 1498021 tcagtccacg aacaaggcgg gggaatctga tcattaatct gagtaatttt ataagttaac 1498081 taggaggaga tggatattat gagcttagca ccacacggag gaacattagt aaacagagta 1498141 gatgaatcat atgatgtgag cggcattcaa aaagaaattg aacttgattt aatttctttc 1498201 gcggatttgg aattgatcgg tatcggtgca tacagcccga ttgaaggttt ctttaatgaa 1498261 aaagattacg tatcagtggt cgaaaacatg cgtctttctt ccggcgttgt ctggtctctt 1498321 ccaatcacgc ttccggtcga tgcgcaaaaa gcagcggaac tgtcacttgg tgaaacggta 1498381 aagttaacgt atgaaggaga aacttacggc gttatccaaa tcgaagacct gtacgtgcct 1498441 gacaaacaaa aagaagctgt caatgtgtac aaaacagatg aacaggagca tcctggtgtt 1498501 aaaaagctgt tcagccgcgg caatacatat gtcggcggac cgattacgtt gattaaaaaa 1498561 gcttcaaaac agttccctga atttacattt gaaccgtcag aaacgagacg ccagtttgcg 1498621 gaaaaaggct gggaaaccat tgtcggtttc caaacaagaa accctgttca cagagcgcat 1498681 gaatacattc aaaaaacggc tcttgaaaca gtagacggct tgttcttgaa tccgttagta 1498741 ggtgaaacaa aatctgatga cattccagct gatgtacgga tggaaagcta ccaagtgctt 1498801 cttgatcatt attacccgaa agatcgtgtt ttccttggtg tctttttagc ggcgatgcgt 1498861 tatgcaggcc cgagagaagc aattttccac gcgcttgtca gaaagaacta cggctgcaca 1498921 catttcatcg tcggccgtga tcatgcaggt gtaggcgact attacggaac atacgaagca 1498981 caggaactgt ttgacacatt taaacctgaa gaactcggaa ttacaccgct gaaatttgag 1499041 cacagcttct tctgtaaaaa atgcggaaat atgggaacag caaaaacttg ccctcatggc 1499101 agagagcatc acgtcatttt atcaggcact aaggtaagag gtatgctgag agacggtgtg 1499161 ctgccgcctg ctgaattcag tcgaaaagaa gtagtagaag tgttaatcaa agggatgaag 1499221 aaaaaagaag aagtaggcgt atcttaagga ggactggcag tgacaaatcg cgatattgta 1499281 tggcatgaag cctctatcac aaaagaagag tatcagcaaa aaaacaagca taaaagctcc 1499341 attctctggc tgacagggtt aagcggctca ggcaaatcaa ccattgccaa cgccgctgcg 1499401 agagaattgt ttgagcaagg ctaccaagtc attgtgctgg acggggataa tatccgtcac 1499461 ggcctaaata gggatcttgg tttttctgat gaagaccgaa aagaaaacat ccgccggatc 1499521 ggagaggtgg cgaagctttt tgttcagcag ggaaccattg tgattactgc ttttatctct 1499581 cctttccgcg aggacagaca acaggttcgc gagcttgtgg aagcgggcga atttaatgaa 1499641 gtctacatta aatgcgacct tgatatttgt gaacaaagag atccgaaagg gctttacaaa 1499701 aaagcaagaa acggcgagat tccgttcttt acaggaattg attctcctta tgaagaaccg 1499761 gaagctccag agctcgttct tgattcagga cagcatgacc gtgaagcgtg taaaaatcag 1499821 ctgatcgagt ttgttaaaca aaaattgagc tgaatatgat ctgctgcgtt cttctcagat 1499881 gccggaatgc aagcgagaac atcatcacag cgaatcttct ggaagaactc gaatagatcg 1499941 ggggaaatac gatggggaaa gtatatattg taggagcggg tcccggtgac cctgatctgc 1500001 tgacaattaa agcgctgaaa gccattgaaa aagctgatgt catcttatat gacagattag 1500061 taaataaaga gattttacaa tatgccaaag agcaagcaga cctgatctac tgcgggaagc 1500121 ttccggattt tcatacgatg aagcaggaaa ccatcaatcg atttcttgtg aagtatgcgc 1500181 aaaaagggaa aatggttgtc agactgaaag gcggagaccc ttttgtgttc gggagaggag 1500241 gggaagaagc ggaatgcctc tctgaaaatg gaattccgtt tgaaatcatt cccggcatta 1500301 cgtctggaat cgcggcagcc gcttatgccg ggattcctgt tacccatcgg gatgcgggct 1500361 ctaacgtcgc ttttgtaacg ggtcactata aaaaagaaga agattttgag gaaaagtgga 1500421 aagcgctggc tacaggaatt gatacacttg tcatctatat gggtatcaaa aacgtgcagc 1500481 agattgaaag aaaactcctt gaaaatggcc gggacggttc tacgccagca gcctttattc 1500541 attgggggac aacggacaag caaaaatctg ttttttgtac agttgacacc ctttcagaaa 1500601 cggtgataaa agaaaacatt acaaatccga gtttaattgt cattggaaat gttgtaaatt 1500661 atcactataa gctggaatgg tttgaatctg aactaaaaaa acaagattta agcgaggcgt 1500721 tgtaaaaatg aaacaagcaa ttttatatgt cggccacggc agccgggtca aaaaagcgca 1500781 gcaagaagcc gcagcctttt tggaaggatg caaggcccac atctctgtgc cagtacaaga 1500841 aatcagcttt ttagagcttc aggagccgac aattgagaca ggatttgaag catgtgtgaa 1500901 gcaaggtgcc actcatatcg cagtggtgcc tctgcttctt ttaacagctg cgcatgcaaa 1500961 acatgatatt ccggaagaaa ttgtccgtgt tgcatctcga tatccatcag tccgtatttc 1501021 atacggaaag ccgatcggga ttgacgaaga agtagtcaag gctgtatatc accgaatgaa 1501081 agacataggt gttccgtatg aaaatgccag agtggtgctc atcggaaggg gaagttcaga 1501141 tccagacgtc aaaagagacg taaccggaat tgctaatctt cttcaggaaa tggttccagt 1501201 gaaggaagtc attccgtgct ttttgacagc atgcggccct aattacaaag aggttttttc 1501261 agaacttgaa aaagatgacg gcataacaac ctttatcgtt ccatatttgc tttttacggg 1501321 tatgctgatg aatgaaatcg aacgagaggt tcagaaatta aaagcccata atccgaacgt 1501381 ctacctctct tcctatatcg gttttcatcc tcatgtgaaa aacgcatttt tgaaccgtgt 1501441 gagagaaact gcggcaaatt ctgagggaca atttgatttt gatggaggtt catatgcttc 1501501 cgctgcacat tagcctggaa aagaagaagg ttgtgattgc ggggggcgga agcatcgctc 1501561 tcagaaggct gaaaacggtg atttctgagg gagctgatat aacgcttgtc agtccggatg 1501621 tggaaccgga aatcaagcaa atggcagaag agcggcgtat caaatgggaa aaacggacaa 1501681 ttgaaaaaga agattatctc aatgctttct tcattattgc tgcgacggat aatgcggcag 1501741 tgaacaaaga aattgcccaa tccgcttcgc cttttcagct tgtcaattgt gtcagtgacg 1501801 ctgagcttgg caatgtatat atgccgaaaa tcgtaaaaag agggcatgtc actgtgtctg 1501861 tttctacaag cggagccagt ccaaagcaca cgaaagagct tgctgaaaac gtggataagc 1501921 tgattgacgg cgattttgtt gctgaagtga acaggcttta tcagatgaga agaaagaaat 1501981 aagccagagc atacaaatgc tctggctttt ctttatgcgg ctcagctttt tttgagcttg 1502041 atgacagtat cagcatcagg cgtgacaaag acggtatgct ggctgtcata agtgacgaaa 1502101 ccgggtttcg cgccgtttgg ttttttgaca tgcctgattt ttgtataatc tacaggcact 1502161 gaacttgaat ctttagcttt tgaaaaataa gctgcaattg tcgcggcttc catgattgtt 1502221 tgctcatcag gttcgctgct tctgatcaca acgtgggagc cgggaatgtc cttcgtgtga 1502281 agccagatat cgtctctggc cgccactctt gtcgttaaat attcattttg acgattgttc 1502341 ttacccacta aaattgtcag ccctgaggtg gattcatatg tttctaacac cggattgtgc 1502401 ggtttttgct ttttctggcc tttttgctgc ttagggcgta aatatttgcc ctcaacaagc 1502461 tcttccctga tttcgctgat atcccgggga gaagcggacg aaagctgctg aatcagctga 1502521 tcaaaatatt cgatctcttc ctgtgccagc ctgatttgct cctcgacaac tgcgaccgaa 1502581 tttttcgctt tctgatactt cgtgaaatag gcctgtgcgt tttcagaagg cgttttgttc 1502641 gggtttaaag gaatcgtgat tgtcgggctt tcttcatcat aataattgat gacctcagcc 1502701 tgtttatcac cttttttcag catatataaa ttagcggtta aaagctctcc gtaaagctga 1502761 aattccttcg cgttttccga atactccagg gttttctcta attttttgat tttgttggca 1502821 ttcttcttcc gttcgttcac aacaaaacgc tcaagatcct gagcctgttg cttaacccgg 1502881 tctcgttcag cttttccgaa ataaaaacgg tcgagcagtt cgcttaatga atcaaaacgg 1502941 cgcgcttcgc cctttagatg agtcagctcc agcagataaa aatattcctt tccgtttaca 1503001 gtcgtaatgt tgggaatgaa acggtgctct ttcacttcgg caaacagtgc cagcaacgct 1503061 tttggcagtg tgactttgtt ggcaaggcct gctctgtgaa ccgcttcttt ggcgaaaagc 1503121 ggagacacgc ctgaaaagtg gtcgacaatt tgtttatcaa gccttccttc ttgaaagctg 1503181 aggtgacgca aaatatcatc ttctgacgcc tcaagaggcg atattttgtc ctgagcaggc 1503241 ggaagcttat aatcttggcc gggcagtact gtacggtagc tgttcattga cggtgataaa 1503301 tgcttaagtc cgtcgataat cacattttct gctgcgtcag tcaaaatgat attgctgtgg 1503361 cggcccataa tttctacata aagctttcgt acggtttcat cgccaatttc gtttcggctt 1503421 ttgatatgaa aaatcataat gcggtctaag cccgcttgtt caattttctc aatgaatccg 1503481 ccttcgatat gctttctcag caacatgcaa aacattggcg gttcgcttgg attttcataa 1503541 gcttgtgccg tgatatgcac ccgtgaatag ctcggatgtg ccgataataa tagtttttgg 1503601 ttttttccct tggcacggat gtggaaaatc acatcgtgct tatatggctg atggattttt 1503661 gtaattcgtc cgcccattat tttctcgtta agttcgtgtg tcattccgta tgtaaacatg 1503721 ccatcaaacg acatatgcaa tacaccctct cattcttcct gcattcgata attatagcat 1503781 gaaatgggac gagtcagaat aagcatgctt atagagtgat atctctataa gagagcaggg 1503841 gagtggacga gcggaatgaa gtttcatgaa atgggacaaa cagatttact agaggcaacc 1503901 aatacgtcca tgaaacaagg attaacagaa aaagaggtaa aaaaacgcct tgacaagcat 1503961 ggaccaaacg agctgcaaga agggaaaaaa acttcagcgc ttctcttgtt tttcgcgcag 1504021 ttcaaagatt ttatggtgct tgtgcttctg gcggcaacgt taatctcagg atttcttggt 1504081 gaatatgtag atgcggttgc gattattgcg attgtgtttg tgaatggcat actcggtttc 1504141 tttcaagaaa ggcgtgctga gcaatctctt caggctttaa aagagctttc aacaccgcac 1504201 gtcatggcac tcagggaagg aagctggaca aagattcctt ctaaggaact ggtgccgggt 1504261 gatattgtga aatttacgag cggggacaga attggcgcag acgttcgaat tgttgaagcg 1504321 agaagccttg aaatagaaga atcagcgcta accggggaat caatcccggt tgtgaagcat 1504381 gctgataaat tgaaaaaacc ggatgtttca ctcggcgata ttaccaatat ggcatttatg 1504441 ggtacgattg tgacccgcgg cagcggtgtc ggggttgtcg tcgggacagg aatgaatacg 1504501 gctatgggga aaattgccga catgcttgaa tcggcaggga cattgtcaac cccgctgcaa 1504561 agaagactgg agcagctcgg gaagattttg attgttgttg cattgcttct gaccgtactt 1504621 gtcgttgctg tcggtgttat tcagggtcat gatctgtaca gtatgttttt agcaggtgtc 1504681 tcgttagcgg tagccgctat tccggagggg ctgccggcga ttgtgacagt ggcgctttcg 1504741 cttggtgtac agaggatgat taaacaaaaa tccattgtta gaaagcttcc tgctgttgaa 1504801 acgcttgggt gtgcgtctat catttgctca gataaaacag ggacaatgac ccaaaacaaa 1504861 atgacagtga cgcatgtctg gtccggaggg aaaacatgga gagtggcagg ggccggctat 1504921 gaaccgaaag gaagcttcac actaaacgaa aaagagatca gtgtcaatga acataagccg 1504981 cttcagcaga tgcttctgtt cggagcgctt tgtaacaact ccaatattga gaaaagagac 1505041 ggcgaatatg tgcttgacgg agatccgaca gagggagcgc tgctcaccgc ggcaagaaaa 1505101 ggcggttttt caaaggagtt tgttgaatct aattacagag tgattgaaga atttccgttt 1505161 gattccgcac ggaaaatgat gactgtcatc gtagagaatc aagacagaaa gcgctatatc 1505221 attacaaaag gtgcgccgga tgtactcatg cagcgatctt cccgtattta ttatgatggc 1505281 tcagcggctc ttttttcaaa tgaaagaaaa gcagaaacag aggcggtatt aagacatttg 1505341 gcatcacagg cgctcagaac gatagcggtc gcctacaggc cgataaaagc aggcgaaaca 1505401 ccgtcaatgg agcaggcgga aaaagatctg accatgcttg gcctttcagg tatcattgat 1505461 cccccgcggc cggaagtcag acaggcgatt aaagaatgcc gtgaagcggg aattaagacc 1505521 gtcatgatta caggtgatca tgtagaaacc gctaaagcga tagcgaaaga cttgcgcctc 1505581 cttccgaaaa gcggcaaaat catggacggc aagatgctga atgaactttc tcaagaagag 1505641 ctttctcatg tggtggagga tgtgtatgta tttgcccgcg tttcccctga acataaacta 1505701 aaaatcgtaa aagcctatca ggagaacggg catattgtgg cgatgacggg agacggcgtc 1505761 aatgatgctc ctgccattaa acaggctgat atcggcgtct ctatgggcat taccgggaca 1505821 gatgtggcca aagaagcatc atctcttgtt ctcgtggatg ataattttgc gacgattaaa 1505881 tcagcgataa aagaaggcag gaacatctac gaaaatatca ggaagtttat cagatacctg 1505941 ttggcgtcta acgtcggaga aatccttgtc atgctgtttg cgatgctgct tgcccttcct 1506001 ttaccgctgg ttccgattca gattttgtgg gtcaacttgg tgacggacgg attgccggca 1506061 atggcgctcg gcatggatca gccggaagga gacgtcatga agcgcaagcc ccgtcatccg 1506121 aaagaagggg tatttgcccg caagctagga tggaaggtcg tttccagagg atttttaatc 1506181 ggagttgcca ctattttagc gtttatcatt gtgtaccacc gcaatccgga aaacttggct 1506241 tatgcccaga cgatcgcgtt tgccacattg gtgctcgctc agcttattca cgtgtttgac 1506301 tgccgcagcg aaacttctgt tttctctaga aatccgtttc aaaacctgta tttaatcggc 1506361 gcggtattgt catccatttt gctgatgctt gtagtaatct actatccgcc gcttcagccg 1506421 attttccata ctgtagccat cacgccgggg gactggatgc tcgtcatcgg tatgtccgcc 1506481 atccctactt ttttgctggc ggggtcactt ttaacaagaa aaaaataaat tcatatgata 1506541 taatcttagg ggtaatagcg tgtctattgc ccttttatta tgagaacagg gaagaattgg 1506601 gtgttttaaa atgatacgaa gtatgacagg cttcggcagt gcaagcaaaa cacaagacga 1506661 tctctctgta agcgttgaac ttaaatctgt gaactacaga tttaaagaag tgaacgctcg 1506721 tttgccaagg cctttgctat attttgaaga taagctgaaa cagaccattc tgcagcatat 1506781 tcagcgcgga agaattgagc ttttcgtatc cgttgacagc gatatgcttg ttgagaaaag 1506841 gcttgaaatt gattggccgc tgctcgatga gtttgtcgca gccgcgagag atatgaagaa 1506901 gcggtatcaa ttgtctgcag agcccgatgt aatggatttc tttaagcttg atcatgtcgt 1506961 ccaggttcat gaagaacaga cgcaaaatga caagctggag gcgttgatca tcgatgctgc 1507021 agaagaagcg gtaaaaggtc tctgtgaaat gcgtgaaaaa gaggggctgc tcttagcgaa 1507081 agactgcctg atgcatattg atcagcttga agagctggtg agagaaactg aattgctggc 1507141 tgcagatgtc gtatctcgtt accgggaacg gctgtatgcc agaatcaaag aatggactga 1507201 agacgtatta gacgagagcc ggcttgtaac agaatgcgct atttttgcag accgctctga 1507261 tatcactgaa gagattacaa ggctgaagag ccacttcgcc cagtttcgtg atatattagc 1507321 tagtggcgga gctgtcgggc gcaaactcga ctttcttgtt caggagctca atcgggaagc 1507381 aaatacgatc ggctcaaaag caaatgatca tcagatcaca aagcttgtcg ttgaaatgaa 1507441 aagttctatt gaaaaaataa aagaacaagt gcaaaatata gaatagtgac tgtgcgtatt 1507501 gtttacagac ggtcttacta ggctaaacta gagacgtcta ttttacaggg ggaacgtaga 1507561 agatgacgat taaactgatt aatatcggat ttggcaatat catctccgcc aatcggatga 1507621 tttcgattgt cagcccggag tctgcgccaa tcaaacggat gattcaggat gcaagagacc 1507681 gcggaatgct aattgacgct acatacggac gaagaacccg tgcagttgtc gtcatggata 1507741 gtgatcacat tatcttatct gccgtccagc ctgagacagt tgcacacaga ctttctgtta 1507801 aagaagaaat tatggatgaa gggcaggggt aattgccgca tgaaagaaag agggttatta 1507861 atcgttctct caggtccctc aggagttggt aaaggaacgg ttcgacaagc gatcttttcg 1507921 caggaagaca caaaatttga atattcgatt tcagtaacca caagaagtcc aagagagggc 1507981 gaagtgaacg gagtcgatta ttttttcaaa acaagagacg aattcgagca aatgattgcg 1508041 gacaacaagc tgcttgaatg ggcagagtat gtcggcaatt attacggcac gccagtcgat 1508101 tatgttgaac agacgcttca agatggaaaa gacgtctttt tagaaattga agttcaaggg 1508161 gctcttcaag tgagaaatgc tttcccggaa ggcctgttta ttttccttgc gcctccaagc 1508221 ctttctgaac tgaaaaacag aatcgtgaca cgaggaacag aaacagacgc tctgattgaa 1508281 aatcgaatga aagccgcaaa agctgagatc gaaatgatgg atgcttatga ctatgtcgtt 1508341 gaaaacgata atgtcgaaac ggcttgcgat aaaatcaaag caatcgttct tgctgaacat 1508401 ttgaagcgtg aacgcgttgc accaagatat aagaaaatgc tggaggttga ataatcaatg 1508461 ttagatccgt caattgattc tttaatgaat aaattagatt caaaatatac gctggtgact 1508521 gtttctgcga gacgtgcccg tgaaatgcaa atcaaaaaag accaaatgat tgaacatacg 1508581 atttcacaca aatatgtagg caaagcttta gaagaaattg atgcaggcct gctttcgttt 1508641 gaaaaggaag accgcgaata gtagcacaag tagcaaccta tatcatgtag gttgttattt 1508701 ttttccgtgc ggttttgtaa agtgcagagg gggagaattc attgcttaac aatcgaaatg 1508761 tgttactttg cgtgagtgga ggcatcgctg tttataaagc ctgtgcgtta acgagcaagc 1508821 tggttcaggc aggagcaaat gtcaaagtga ttatgactga atccgcttgc cgattcgttt 1508881 caccgctgac atttcaggca ttgagccgcc acgaagtcta tacagataca tttaaagaac 1508941 aaaatccaag cgtcatttct catattgatg ccgcagactg ggccgacttg attatcgtag 1509001 cgccggctac ggctaatgtg attggaaaac tggcaaacgg catcgctgat gatatgctga 1509061 cgacaacatt gttggcagca acggctcccg tttggatcgc gccggcaatg aacgttcata 1509121 tgtatgacca cccggcagtc aaacgaaaca tttctgttct ttatcaggac ggttattgtt 1509181 ttattgagcc aagtgagggc tatttagcat gcggttacgt aggaaaaggc agattggaag 1509241 agccggaaaa catcgtaaag ctggccgaaa aacattttgc tgaagaaaca tccgctcctt 1509301 tagaaggcaa gcatgtggtc attacagccg gcccaacgcg ggaagcgatt gatcctgtcc 1509361 ggttttttac caataaatcg acgggcaaaa tgggctacgc actggcggag gctgctgttc 1509421 agctcggcgc acgggtaatc ttaatttctg ggcctgtttc acttgatcag cctaaaggcc 1509481 ttgctgagtt tatccctgtt caatcggctg cggatatgcg cgaagctgtg ctctctgtgt 1509541 atgacgcaag cgatatagtc attaaaacag ctgcggtagc cgattttacg ccgaaaacag 1509601 tatttgacca taaaatgaaa aaacaagacg gcggcatgac cttagaactg aaaagaacag 1509661 tcgatatttt gaaagaattg ggcgagaaaa agaaagagca gattttggtc ggatttgccg 1509721 ccgaaacaca agacattgaa cactatgcac gtaaaaagct cgccgctaaa aaccttgatt 1509781 tgattgtggc aaatgatgtg aaagcaaatg gggccggttt tggtgctgat acgaatatcg 1509841 tgacaatctt tttcaaagac gggcataaac gcgaactccc gattatgtct aagctcgatg 1509901 tttcttttga aatccttcag gagatcgcag ccctctcaaa acaaaccgga gagcgctcat 1509961 gaattttgca gaagtcatcg ttgatgtcag caccaaaaat atagacaggc cttttgatta 1510021 taaaatccca gaccatctga agggcatgat caaaacgggg atgcgggtca ttgttccgtt 1510081 tggcccccgt aagattcaag ggtttgtgac agcagtcaaa gaagcatctg acctatcggg 1510141 aaaatctgtc aaggaagtag aggatttatt agatcttaca cctgttctga cagaggagct 1510201 tatgattctg tcatcatggc tgtcagacaa aacgctgtct tttaaaataa cggcgcttca 1510261 agcaatgctg cctgccgcct taaaggcgaa atatgaaaaa gaattaaaaa ttgcacacgg 1510321 agccgatctt ccgccgcaag tggaacggct gttttctgaa acaaagacgc tgctgtattc 1510381 agatataccc gatcatgaga cgctgaaact gattcaaagg catgttcaaa aaggggacat 1510441 tgacgtgacg tataaagtcg cgcaaaaaac caataaaaaa atggtcaggc atattcaggc 1510501 aaatgcgagt aaagaagagc ttgctaagca ggctgaggga ttgtcccgcc aagcagcaaa 1510561 acagcaggcg attcttcact ttctcatctc tgagccggaa ggtgtgaaaa ttcctgcggc 1510621 ggaattgtgc aaaaaaacgg acacgagctc tgcaaccatc aaaaccctta tccaaaaagg 1510681 gcttttgaag gaaagctatg aagaggttta cagagatccc tatcaggaca aaatgttcaa 1510741 aaaaacagag cccctgccgc tgacagacga acagagggct gccttcgagc ccatacgcga 1510801 gacattggac agcgatgagc ataaagtgtt cctccttcac ggcgtgacag gaagcggaaa 1510861 aaccgaaatt tatctgcaat caattgaaaa agtactggcg aaaggaaaag aagccatcgt 1510921 cctcgtaccg gaaatatcgc tgacgccgca aatggtcaac cgcttcaagg gccgcttcgg 1510981 ctcccaggtg gcagtcatgc acagcggttt atccacagga gaaaaatatg acgagtggcg 1511041 taaaatccac cggaaggaag tacggcttgt cgtcggtgcc agatccgcca tttttgctcc 1511101 gtttgaaaat ctcggaatga taatcatcga tgaagagcac gagtcttcct ataaacagga 1511161 agaaatgccg cgctatcatg cgaaagaggt ggcaatcaag cgggctgagc atcacagctg 1511221 cccggttgta ttagggagtg ctacgccgac attagaatca tatgctagag cgcaaaaggg 1511281 cgtatacgag cttctttcac tgaagcaccg tgttaaccat cgggtgatgc ccgaggtttc 1511341 gcttgtcgat atgagagagg agcttagaaa cggcaatcgc tcgatgtttt cagttgaatt 1511401 gatggaaaag cttgaagaaa cgattgccaa gggtgagcag gcggtgctgt ttttaaataa 1511461 gaggggctac tcttcctttg tgatgtgcag ggattgcggc tatgtcccgc aatgcccgca 1511521 ctgcgacatt tccatgacgt atcatcgtta cggccaaagg ctgaaatgcc attattgcgg 1511581 acatgaagag cctgttccgc acacttgtcc tgaatgcgca agcgagcata tccgcttttt 1511641 cggaacggga acacagcgag tggaggaaga gctgacaaaa gtgctgccaa gtgcgagagt 1511701 gattcggatg gatgttgaca cgacatcacg gaaaggcgcc catgaaaaat tactgtcagc 1511761 tttcggagaa ggaaaagcgg atattcttct cggaacgcaa atgatcgcga aagggcttga 1511821 ttttccgaat gtcacgcttg tcggagtgtt aagtgctgat acaacacttc atattcctga 1511881 tttcagatcg gctgaaaaaa catttcagct gttaacgcaa gtcagcggcc gggcaggcag 1511941 gcatgaaaag cccggccatg tcatcattca aacgtataca ccgtctcatt acagtatcca 1512001 gctgacgaaa acacacgatt atgaaacgtt ctatcagcat gaaatggcgc acaggagaga 1512061 gcaatcctat ccgccatact actatttggc tcttgtgact gtttctcatg aggaagtggc 1512121 gaaagcagcg gttacagctg aaaaaatcgc tcattttttg aaagcaaact gcggagctga 1512181 cacgaaaatt ctcggaccaa gcgcgtcgcc gatagccagg atcaaagata gatatcgcta 1512241 tcaatgcgtg ataaaataca aacaggaaac ccagttatcc gctttattga agaagatact 1512301 ggaacattat aaacgcgaaa ttgaacaaaa acatgtaatg atttcaattg atatgaatcc 1512361 ttatatgatg atgtaagatc tcacgtcttg gagggtaaca aattggcagt aaaaaaggtc 1512421 gtcacacatc ctgcggaggt tttggaaaca cctgcggaaa ccgtgactgt ttttgataaa 1512481 aagctaaaaa aactgcttga tgatatgtac gacaccatgc ttgaaatgga tggtgtcgga 1512541 ctggcagcgc cgcaaatcgg cattttaaaa agagcggccg tcgtagaaat cggggatgac 1512601 agagggagaa ttgatctcgt taatcctgaa attttagaaa aaagcggcga gcaaaccgga 1512661 attgaaggat gcttgagctt tcctaacgtc tatggtgatg tcacacgtgc cgattatgtc 1512721 aaagtgcgtg cgtttaaccg tcagggaaaa ccgttcattc tggaagcgcg aggcttttta 1512781 gcaagagccg tgcagcatga aatggaccac ttagacggtg tgctgtttac atctaaaata 1512841 agtaaatact atacagaaga tgaactagcg gatatggaag gatgatttga tgacgagaat 1512901 cgtatttatg ggaacgccgg atttttcagt tcctgtttta agaaccctga tagaggacgg 1512961 atatgaagta gtgggggtcg tcacacagcc ggaccgtccg aagggcagaa aaaaagtact 1513021 gacacctcct ccggtaaagg aagaggcatt gcgccacggc atcccggttc ttcagccgga 1513081 aaaagtcaga ttgacagaag aaattgaaaa agtgctggca ttaaagcctg acctgattgt 1513141 aacggcggca ttcggacaaa ttttgcctaa agagcttctc gacagtccaa aatacggctg 1513201 cattaacgtt cacgcatccc ttttgccgga actgcgcggc ggtgctccga tccattattc 1513261 cattctgcag ggaaagaaga aaaccgggat taccattatg tatatggtag aaaaattgga 1513321 tgcgggcgat atgatctcaa aagtggaagt ggacattgaa gaaaccgaca atgtcggaac 1513381 actgcacgat aaattaagcg ttgctggcgc gaagctattg tctgaaacgg ttccaaacgt 1513441 tattgccggc agcatatcac ctgaaaagca ggatgaagag aaagcgacgt acgcgcctaa 1513501 cattaaaaga gagcaagagc tgctcgactg gtccagaacg ggcgaagagc tttacaacca 1513561 gatccgcggc ttaaatccat ggcctgttgc ttatacgact ctaaacggac aaaacttgaa 1513621 aatatgggcg tcgaaaaaaa tagcggcacc aacaacagct gagcccggca cagtcgttgc 1513681 agttgaaaag gaaggaatta tcgttgccac aggtaacgag acggctctgt tattaaccga 1513741 actccagccg gcaggcaaaa aacgaatgaa aggcgaagac tttgtgcgag gcgctcatgt 1513801 tgaagccggt gatgtgttag gagtaaacaa tgaaaaaaac tagtgttcgt gacatcgccc 1513861 ttgaggcgct gatcaaatta gaacaaaacc aggcatacag caacctgctg ctgaaatcgg 1513921 tcattaaatc aaatgaactg agtgatcaga acagagggct tttgactgaa cttgtctatg 1513981 gtacattaca aaataagatc gcgcttgatt atatgcttaa accgtttatc aataagcctc 1514041 aaaaggtaaa gccgtgggtg attcagcttc ttcgcctatc cttatatcaa atggagtatt 1514101 tggagaagat tccagacagg gcagccattc atgaagcggt tgagattgct aaaatccgcg 1514161 gacacaaagg cattgcttca tttgtcaacg gcgtgctccg ttctattcag cgcgaaggtg 1514221 ttccatcctt tgacgcgatc gaagatcctg tccgccggct ggcgacagaa acaagccatc 1514281 cggaatggct tgtgaaagag tgggcggatg cgtatggatt tgaagctgcg gaaaagattt 1514341 gccgcatcca tctcattccg ccgaaacaga cgctgcgtgt caatcaaatg aaagcagaca 1514401 gagctgagct gcttgaccaa atggctgctg agggaatcga agttgaaaaa ggcgacctcg 1514461 ctgaagatgc tgtgaagctc ttaaagggaa caattgccgg aactcatttc ttccaaaacg 1514521 gcgaagtttc tatccaggat gagagctcca tgctcgtcgc ccgcgccctt gatcctaagt 1514581 cagatgaaac agtgcttgac gcgtgtgcgg cgcctggcgg aaagtcggct catatcgcag 1514641 aattaatgaa gaacaagggg agcgttacgt cgcttgatct tcacaaacat aaagtgaagc 1514701 tgatcaaaga agcggcagat cggcttggcc tgacaatcat tcatgcggaa acaatggatg 1514761 ctagaaaagc gggggaaacg tttgaaaacg aacagtttga ccgaatattg gtcgatgccc 1514821 cgtgctcagg tttcggtgtt atcagaagaa agccggacat gaaatacacg aaaaaacctg 1514881 acgacagcgc ccgtctagct gaaatccagc tgtcgatctt gagggaaatc gcaccattag 1514941 taaaaaaagg tggcactctt gtctacagta cgtgtacaat ggaccggaca gaaaatgatg 1515001 aagtaataca tgcgtttata caagaacatc ctgattttga acccgatttg tctcttgaaa 1515061 agcggctgcc tgaaaaggtg agaccctttg ttcgggatgg aaggcttcaa atccttcctc 1515121 attatttcgg aacagatggt ttctttattt gcagcatgag aaagaaggga taagcaatgg 1515181 cagaacttaa taaaacaaaa gtaagaaaag aattgcggac agagcgtccg tctatttatt 1515241 cttttgaatt agatgaaatc aaacaatggc tgacagacaa tggagagaaa ccgttccgtg 1515301 cagcccagat ctttgaatgg ctatatgaaa aacgcgtatc ttcttttgaa gatatgacaa 1515361 acctctcaaa ggatctgcgt gagaaattaa acactcgctt tgtgttaaca acgctgaaaa 1515421 cggctgttaa acaaacctct caagacggta cgatgaagtt tttgtttgag cttcatgacg 1515481 gttataccat cgaaaccgtt ttaatgagac acgagtatgg caattctgta tgtgtaacga 1515541 cacaagtcgg ctgccgtatt ggctgcacat tctgcgcgtc aacgcttgga ggcttaaaac 1515601 gaaaccttga agcaggggaa attgtcgctc aagtagtcaa agtgcaaaaa gctcttgatg 1515661 aaacggatga acgcgtcagc tctgtcgtga tcatgggaat cggcgaacct tttgataact 1515721 ttaacgaaat gctcgctttc ttgaaaatca ttaaccatga caagggcctg aatatcggtg 1515781 ctcgccatat tacggtctct acgagtggaa tcatcccgaa aatttacgaa tttgctgatc 1515841 agcaaatgca gattaacttt gcaatttctc tgcacgcgcc gaacacagaa atcagaagcc 1515901 gtttgatgcc gattaacaga gcatataaac tgcctgatct aatggaagcc gttaaatatt 1515961 atattaataa aacaggacgc cgtatcagct ttgaatacgg gctgttcgga ggcgtaaacg 1516021 accaggtgga acacgccgaa gagcttgccg acttgctgga aggagtcaaa tgccacgtga 1516081 acttgattcc ggtaaactac gtgcctgaac gggactatgt gcgcacaccg cgtgatcaga 1516141 tttttgcttt tgaaaaaacg ctgaaatccc gcggagtaaa tgtcacaatc cgaagagagc 1516201 aaggacatga cattgacgca gcctgcggtc agcttcgcgc gaaggagcgt caagacgaga 1516261 cgaggtgatg agggttgtta acagccttaa aaacagatac aggaaaaatc cgccagcata 1516321 atgaagatga tgcggggata ttcaagggga aagatgaatt tatattagcg gttgtcgctg 1516381 atggcatggg cggccatctt gctggagatg ttgcgagcaa gatggctgtg aaagccatgg 1516441 gggagaaatg gaatgaagca gagacgattc caactgcgcc ctcggaatgt gaaaaatggc 1516501 tcattgaaca gattctatcg gtaaacagca aaatatacga tcacgctcaa gcccacgaag 1516561 aatgccaagg catggggacg acgattgtat gtgcactttt tacggggaaa acggtttctg 1516621 ttgcccatat cggagacagc agatgctatt tgcttcagga cgatgatttc gttcaagtga 1516681 cagaagacca ttcgcttgta aatgaactgg ttcgcactgg agagatttcc agagaagacg 1516741 ctgaacatca tccgcgaaaa aatgtgttga cgaaggcgct tggaacagac cagttagtca 1516801 gtattgacac ccgttccttt gatatagaac ccggagacaa actgcttcta tgttctgacg 1516861 gactgacaaa taaagtggaa ggcactgagt taaaagacat cctgcaaagc gattcagctc 1516921 ctcaggaaaa agtaaacctg cttgtggaca aagccaatca gaatggcgga gaagacaaca 1516981 ttacagcagt tttgcttgag cttgctttac aagttgaaga gggtgaagat cagtgctaat 1517041 cggcaagcgg atcagcgggc gttaccaaat tctccgcgtc ataggcggcg ggggaatggc 1517101 caacgtgtat ttagctgagg atatcattct agaccgtgaa gtcgcaatta aaatcctgcg 1517161 gtttgactat gcaaatgaca atgaatttat cagacgtttc cgcagagaag cccaatccgc 1517221 atcaagcctc gatcacccga atattgtcag catttatgat ttgggcgagg aagatgatat 1517281 ttattatatt gtcatggaat acgttgaagg catgacgctt aaagaataca taacagcaaa 1517341 tgggccgctt caccctaaag aagcgctgaa catcatggag caaattgtct cagccatcgc 1517401 tcatgcccat caaaaccaga ttgttcacag agacatcaag ccgcataaca ttttgattga 1517461 tcatatggga aatatcaaag taacggattt tggaattgcg acggcactaa gttcgaccac 1517521 aatcacccat accaattcag ttctgggctc ggtccattac ttatcacctg aacaggcccg 1517581 gggcggctta gccacaaaaa aatcggatat ttatgcgctt ggaatcgttc tatttgagct 1517641 tttaaccggc cgtattccgt ttgatggaga gtcagcagtc agcatcgcct tgaagcatct 1517701 tcaagcggaa actccttcgg caaaaaggtg gaatccatcg gtcccccaaa gcgttgaaaa 1517761 catcatactc aaggcaactg ccaaagatcc ttttcatcgc tacgaaacgg ctgaagacat 1517821 ggaagcagac ataaaaacag cttttgatgc cgacagactc aatgaaaaga gatttacgat 1517881 tcaagaagat gaagaaatga caaaagcgat acctatcatt aaagatgaag aacttgctaa 1517941 agctgctggc gaaaaagaag ctgaagtgac aaccgcacaa gaaaacaaaa caaagaagaa 1518001 cggcaaaaga aaaaagtggc cgtgggtttt gctcacgata tgcctcgttt ttatcacagc 1518061 tggaattctt gctgtcactg tttttccgtc gcttttcatg cctaaggatg tcaaaatacc 1518121 tgatgtctcc ggaatggaat acgaaaaagc cgcagggctc ttggaaaaag aaggtttaca 1518181 ggttgattcc gaggtgttgg aaatctcaga tgaaaaaatt gaagagggcc tgatggtaaa 1518241 aacggatcct aaagcggata ccacagtcaa agaaggcgcc acggtcaccc tttataagag 1518301 caccggaaaa gcaaaaacgg agatcggtga tgtgacaggc caaacggtcg accaagcaaa 1518361 aaaagcgttg aaggaccaag ggtttaatca tgtaacagta aatgaagtga atgacgagaa 1518421 aaatgcgggc actgtcattg accaaaatcc ttcagcaggg actgagctgg tcccgagtga 1518481 agatcaagtc aaacttacag tcagtatcgg acccgaagac attacgctta gagacttgaa 1518541 aacctacagt aaagaagcag cgtctggata tctggaagac aacggattga agcttgtaga 1518601 aaaagaagca tactcagatg atgttccaga aggacaggtt gtcaaacaaa aaccagcagc 1518661 aggtacggca gtaaagccgg gaaacgaagt tgaagtgaca ttctctctcg gaccagagaa 1518721 aaaacctgcg aaaacagtga aagaaaaggt caagatcccc tacgaaccag aaaatgaagg 1518781 ggacgagctt caagtgcaaa tcgcggttga cgatgcggat cacagcatct ctgacactta 1518841 cgaagaattt aagataaaag agccgactga acgaacgatc gaactaaaga ttgaaccagg 1518901 ccaaaaaggg tactatcaag taatggtaaa caataaagtt gtcagctaca aaaccattga 1518961 gtatccgaaa gatgaataac aaggagggaa aatatgcctg agggcaaaat tattaaggcg 1519021 ctaagcggct tttactatgt actggatgaa tcagaggatt cagataaagt aatacaatgc 1519081 agaggaagag gcattttcag aaaaaacaaa attacccctc ttgtcggtga ttacgttgtg 1519141 tatcaagctg aaaatgacaa agaaggatat ctaatggaaa ttaaagaaag aaccaacgag 1519201 cttatcaggc cgccaatttg caacgttgat caagcggtcc ttgttttctc agcggttcag 1519261 ccttctttca gcacggcatt gctcgaccgc ttcctggttc tcgttgaggc caatgatatt 1519321 cagccgatta tatgcattac taaaatggat ctgattgaag atcaagatac agaagatacg 1519381 atacaagcct atgcagaaga ctatcggaat attggttatg acgtatacct tacctcctct 1519441 aaggaccaag atagtttagc ggacatcatc ccgcattttc aggataaaac aacggtattt 1519501 gccggtcagt ccggtgttgg gaaatcctcg cttctcaacg cgatcagtcc ggagctcgga 1519561 ttaagaacaa acgagatttc cgagcatttg ggccgcggga aacacacaac ccgccacgtg 1519621 gagctgattc acacgtccgg aggtttggtt gcagatacac cgggattcag ctcgcttgaa 1519681 tttacagaca ttgaggaaga agagctgggc tataccttcc ctgatatcag agaaaaaagc 1519741 tcttcatgca aatttagagg ctgtttacat ctgaaagagc cgaaatgtgc ggtgaaacaa 1519801 gctgttgaag acggggaatt aaagcagtat cgctatgacc attatgttga atttatgacg 1519861 gagattaaag acagaaagcc gaggtattag cataatgata aaggttgcac catctattct 1519921 ttccgctgat tttgccgctt taggcaatga gattaaagat gtagaaaaag gcggagccga 1519981 ttgtattcat attgatgtta tggacggcca ttttgtcccg aatatcacaa tcggtccgct 1520041 gattgtagaa gcggtccggc cggtaacgga tctgccgctt gatgtccatt taatgataga 1520101 agagccggat cgttatatcc cggcttttgc gaaagcaggc gcagatatcc tgtctgtgca 1520161 tgctgaggca tgtccgcacc tgcaccgtac catccagctc attaaagagc aaggagtgaa 1520221 ggccggagta gttctaaacc cgcatacccc tgtacaagtc atcgaacatg ttttcgacga 1520281 tcttgatctt gttcttttaa tgacggtgaa cccgggcttc ggcgggcaga aatttattca 1520341 ttcagtcctt cctaaaataa aagaggttaa gcgaatggcg gatgaaaaag gaaaaaaaga 1520401 tctgttaatt gaagtagacg gcggcgtcaa caaagaaacc gctccgctcg tcattgaagc 1520461 gggcgcaaat ttactcgttg ccggttcagc tgtttatggc cagtctgacc gcaaaaaagc 1520521 aatttctgaa atcagaggaa gtaaataagc agctttagaa aagagctggg catacaatag 1520581 cctaagctct ttttcctgta tgcagagaaa ggaatcagag atgaaaacaa ttaatatcgt 1520641 tgcgggaggc ccgaaaaatc tcattcccga tctaaccggc tatacggatg aacacacgct 1520701 ttggatcggt gttgacaaag gcaccgtcac tctcttagat gccgggatca ttcctgttga 1520761 agccttcgga gattttgaca gcataacgga gcaagaacgc cggcgaatag aaaaagccgc 1520821 tcccgccctt catgtgtatc aagcagaaaa agatcaaaca gatttagacc tcgcccttga 1520881 ttgggcgctg gaaaagcagc cggatattat tcagattttc ggcattacag gcggcagagc 1520941 tgatcatttt ttaggaaaca ttcagcttct gtataaaggt gtaaaaacga acataaaaat 1521001 taggctgata gacaaacaaa atcatattca aatgttccct cctggtgaat atgatattga 1521061 gaaggatgaa aataagcgat atatctcctt cataccgttt tccgaagaca tacatgagct 1521121 gaccctgacc ggttttaaat atcctctaaa taattgtcat attacgctcg gttcaacact 1521181 atgtattagt aacgaactca ttcattcacg aggtactttt tcgtttgcaa aaggcatatt 1521241 aataatgata agaagcacgg attaagcatg tgctttcatt caattgctga aaacaatgaa 1521301 caaggcggtt acgggacgtt ataggagggg acaaaaatga aattttacac cattaaattg 1521361 ccgaagtttt taggaggaat tgtccgggcg atgctgggct catttagaaa agattaatgc 1521421 ccaggggttc aaagccctct ttcaccacat aaaaacgcct gccacatatc ggggcaggcg 1521481 ttcattttgt tatacacgct caactttacc ggatttcaaa gctcgagcag atacatatac 1521541 ttttttaggt tttccgttca caaggatacg aaccttttga agattcgcgc cccaagtgcg 1521601 cttagaagcg ttcattgcgt gagaacggtt attcccagct gttgtttttt tacctgtgat 1521661 aacgcattta cgtgccattt gtttccctcc tcacttgcac aaaacatcta ctttttaaca 1521721 ttcatataat cttagatgct ttcgatatgg atactttaaa taatttacca cagctaaaaa 1521781 acgtttgcaa ctattgtttc atcatctttc aagaaaattc acttgacatc ttgcggaaac 1521841 agcagcgcta tagtatatgt agaggtacgg ccagcgatta ttgcctggtc ttttcataat 1521901 ggaaaccata tagtagaata gctgtaactc tatgcattcg aaggaggaac tagtgtgtcc 1521961 attgaattaa gaacgaagta cggacagatt gatatatcta atgaagtcat cgcgatggtt 1522021 gcaggaggcg cggcggttga ctgttacggc attgtcggca tggcctctaa aaaccagatt 1522081 aaagacggac tgactgaaat ccttcggaaa gagaatttca gcaggggtgt ccaagttcgc 1522141 caagaaggag aacagataca tatcgacatg tatatcattg tcagctacgg cacgaaaatt 1522201 tctgaagtgg cacataatgt ccaaacaaaa gtaaagtaca cagtaaatca aaccatcgga 1522261 ctggcagtgg attctgtcaa tatttatgtc caaggcgtac gagtgacgaa cccgtagtta 1522321 ggaggagtag gattgtctat cagaacatta gacggcagaa cctttgccga gatgattctt 1522381 gcgggagcgc agaatctgtc tcaaaacgcc agtgcagttg atgcactgaa cgtgttcccg 1522441 gtgccggacg gtgatacggg aacaaatatg aacctgtcga tgacttccgg agcaagagaa 1522501 gttgaacaaa tggatacgga tgatatcggg aaggtgggct ccgcgttatc taaagggctg 1522561 ctcatgggag cacgcggaaa ttcaggagtt atcctatccc aattgttccg cggatttagc 1522621 aaaaacattg aaacgaaaaa agaaattaat gcacttgagt ttgccgctgc gctgcaagca 1522681 ggtgtagaca tggcgtataa agctgtcatg aaacctgtag agggcaccat tttaacagtt 1522741 gcaaaagacg ctgcaaaaaa agcaatgatc ttagcagaaa aagaaaccga tatcactgcg 1522801 ctgatgactg cagtgacaga agaagcagag gcgtctttaa accgcacccc tgaattgcta 1522861 cctgtcctaa aggaagtagg agttgtcgat agcgggggca aaggcctgct ctgtgtgtat 1522921 gaaggtttcc ttgcttcatt aaaaggtgaa actgtacctc agaaagcagt tcttccgtca 1522981 cttgacgaca tggtcagcgc agagcatcac aagagcgcgc aaagcatgat gaataccgaa 1523041 gatattgaat ttggattctg taccgaagtg atggttaggc ttgatcagac aaaaagagag 1523101 ttcgacgaag gcacgttcag gcaagacctc agccagttcg gagattctct gcttgtgatt 1523161 gcggatgaat cgctggcgaa ggttcatatt catgctgaag agccgggaaa cgtgttaaac 1523221 tacgcccagc attacggtga attgatcaaa ataaaaatag aaaatatgag agaacagcat 1523281 acctctatca tcagtcaaga aagcaaacct gcagacaacg aaacaccgcc ggcaaaacag 1523341 ccgtatggca ttgtgactgt agcgatggga gaaggaattg cagacctatt taaaagcatt 1523401 ggcgcttctg ttgtgattga aggcggccag accatgaacc caagcactga ggatattgtt 1523461 gatgccgtga agtctgtaaa tgcagatacg gtatttatcc tgcctaacaa ctccaacatt 1523521 atcatggctg ctaaccaagc ggccagcgta gtggatgaac aggtttttgt cattcctgct 1523581 aaaacggttc cgcaagggat gtcagctctg ctggctttta acccggatca agaagctgaa 1523641 gcgaacgagg ccaatatgct aagcgccatt cagcaagtaa aaagcggaca ggtgacgttc 1523701 tcagtcagag atactcatat tgacggtaaa gacattaaaa aaggcgactt tatgggcatt 1523761 ctgaatggaa cgattatcgg cacttctgaa aatcagctgt cagccgcgaa aatgctgctg 1523821 tcagaaatga tcggagaaga tgatgaaatc gtgaccattc tatatggtga ggatgcgtct 1523881 caggaagaag ctgagcagct tgaagcgttt ctcagtgaaa agtacgagga gattgaggtt 1523941 gagatccaca atgggaaaca gcctctgtat tcgtatatag tttcagcaga atagaagggc 1524001 aatttgccct tctattctta tgtctgcttt taagtgcggc agcgctgtaa cgcgcccgct 1524061 tgccatttta tatctgatca attagtctag aagcaaagcg ctaataagct ctggttcata 1524121 aggaggaata gcatgaaata cagaagcgtt tttgatatta tcggcccggt tatgatcggt 1524181 ccgtccagct ctcatacagc gggagctgct agaatcggga gagtggccag aagtttattt 1524241 ggcagagagc ctgagcgcat cattgtatct ttttacggct cgtttgcgga aacgtataag 1524301 ggccacggca cagatgtcgc gattatcggc ggattgcttg attttgatac attcgatgaa 1524361 cggattaaaa ccgctataca aattgcagaa gctaaaggaa ttgatataga gtttcgggta 1524421 gaagacgcag tcccggtcca cccgaacaca gcaaaaatca ccatttctga tgaaaagggt 1524481 gagctggaac tgacgggtat ttcgattggc ggaggaaaga ttgaaatcac agaattgaat 1524541 ggttttgagc tccggctgtc aggaaatcat ccggccatat tagttgttca taatgacaag 1524601 tttggcacaa ttgccggtgt tgccaatgtt ctggcgaaat tttcaatcaa cgtaggacat 1524661 atggaagtag cccggaaaga tatcggccag cttgcgctga tgacaataga ggtcgatcaa 1524721 aatattgacg accacattct cgacgagctg tcgaagctgc cgaatattat tcaagtgaca 1524781 aagattgctg actagcgaaa agggtcagga ggagccagtt atgtttcgta atgtaaaaga 1524841 attaattgag attactaaag aaaaacaaat attgatctct gatgtgatga tagctcaaga 1524901 gatggaagta acagaaaaaa caaaagagga catttttcag cagatggatc ataacctgtc 1524961 tgttatggaa gcggcggttc agaaaggact cgagggagtt acgagccaaa cgggcttaac 1525021 aggcggagat gccgttaaat tgcaggccta tattcgatca ggaaaaagcc tgtctggccc 1525081 gctgatttta gatgctgtat cgaaagccgt tgcaacaaat gaagtaaatg cagccatggg 1525141 aaccatctgt gcgacaccga ctgcaggttc tgccggtgtg gtgcccggta cgttatttgc 1525201 tgtaaaagaa aagctgaatc caacaagaga acaaatgatc cgctttttgt ttacagccgg 1525261 ggctttcgga tttgtcgtgg ccaataacgc aagcatttcc ggcgccgccg gaggatgtca 1525321 ggcagaggtt ggatcagctt caggcatggc ggctgcggct attgttgaaa tggcaggagg 1525381 aacacccgaa caaagcgcgg aagccatggc cattacatta aaaaatatgc taggcctcgt 1525441 gtgcgaccct gttgcagggc ttgttgaggt gccttgcgtg aaacggaatg cgatgggcgc 1525501 gtcaaatgcg atgattgctg ctgatatggc attggcgggc attacaagcc gtattccatg 1525561 tgatgaggtt atcgatgcca tgtataaaat aggccaaacg atgccaactg cacttagaga 1525621 aacaggccag ggcggtttag cggcaacacc gacaggaaga gaattagaga aaaaaatttt 1525681 cggaggagcg ctaggttcac gtgaaacaac atcagcaaac tagtatagct aacattaagg 1525741 gtattgggcc ggaaacagaa aaaacattga atgaactcgg tatttatgac atttctgatc 1525801 ttctgaatta tttcccttat cgctatgatg actacgagct gagggattta gaagaagtaa 1525861 agcatgatga aagagtcaca gtcgaaggga aggttcattc agagccttct cttacctatt 1525921 acggaaaaaa acgaaacagg ctgacattca ggcttctggt cggccactat ttaatcacag 1525981 ccgtatgttt taaccggcct tatttgaaga agaagctttc gctcggctct gtggtgacgg 1526041 tttcaggtaa atgggacaag caccgccaaa ccatctctgt tcaggagttg aaaaacgggc 1526101 cgcatcaaga agacaaaagc attgaaccag tgtattctgt gaaagaaaat gttaccgtca 1526161 aaatgatgag gcgctttatt cagcaggcgc tgacccaata tgcagactca cttcctgatc 1526221 ctcttccgga aaagctaaga aaaagctata aactgcctga ctattatcaa gcgttaaaag 1526281 caatgcacca gcctgaaaca agggaagcat taaagcttgc cagacggcgg tttgtttatg 1526341 aagaattttt gttgtttcag ttgaaaatgc aggcgttccg aaaggcggaa agagagcaga 1526401 cacaagggat acggcagcgt ttttcaaacg aagaactcat gagatttatc aaaagcctcc 1526461 cgtttcccct cacaaacgcc cagtcacgcg ttcttcgcga aataacagca gacatgtctt 1526521 ctccatacag aatgaaccgt cttcttcaag gggacgttgg atcaggaaaa acggcagtcg 1526581 ccgccattgc actgtatgcc gcgatcctat ccggatacca aggagcgctc atggtgccga 1526641 cagaaattct ggccgagcag catgctgatt cgctcgtttc gctatttgaa aaatgggacg 1526701 tcagcgttgc tcttttgaca agctctgtta aaggaaagcg gcgaaaagaa ctgcttgagc 1526761 gtcttgcggc gggtgagatt gatattcttg taggaaccca tgctttaatc caagacgagg 1526821 tggagtttaa ggcgttgagt ctcgttatta ctgatgaaca gcacagattt ggagttgagc 1526881 agcgcaaaaa gcttcggaac aaagggcagg atcccgatgt tctctttatg acagccactc 1526941 caatcccaag aacattagcg atcacagtat tcggtgaaat ggatgtatct gtcattgatg 1527001 agatgccggc tggacgaaag cgaattgaaa cctattgggt aaaacatgac atgcttgatc 1527061 gtattttggc atttgtcgaa aaagaattaa agcaaggcag gcaggcttat atcatctgtc 1527121 cgctgattga agaatcagat aagcttgatg tgcaaaacgc cattgacgtg tacaatatgc 1527181 tttctgatat ttttcgggga aaatggaatg tcggccttat gcatggaaag ctgcattccg 1527241 atgaaaaaga tcaggtcatg agagaattca gcgcaaatca ctgtcaaatt ctcgtatcaa 1527301 ccactgttgt ggaggttggc gtaaatgttc cgaatgcaac aattatggtg atttatgacg 1527361 ccgaccgttt cggactatca cagcttcacc agctgcgcgg ccgtgttgga cggggtgagc 1527421 atcaatcttt ctgtattctg atggctgatc caaaatcaga aacagggaaa gaacggatga 1527481 ggatcatgtc ggagaccaat gacggtttcg agctgtctga aaaggatctg gaactgagag 1527541 gtcccggtga tttcttcggg aaaaaacaaa gcggaatgcc ggaatttaaa gtggcggaca 1527601 tggttcatga ttacagagcg cttgaaacgg caaggcagga tgctgcgaat cttgtggctt 1527661 ctgacgcgtt ctggaaggag ccggaatacg ctgtgttaag agatgaattg ctgaagagcg 1527721 gagtaatgga cggggaaaaa ttaagctgag tatcagaagt ttttggtgtt cagccagaaa 1527781 caatcgttgc attccaatct atgaaattat atactactat tagtacctag tcttaattgt 1527841 ccggatggtg tttagatatg agaagaaata agagagaacg ccaggaatta cttcagcaga 1527901 cgattcaagc aacccccttt attacagatg aagaactagc gggtaaattc ggggtgagca 1527961 tccagacgat acgtttggac cgcttagagc tttccatacc tgaactgaga gaaagaatta 1528021 agaacgtggc agagaaaaca cttgaggacg aagtgaagtc cctgtcactt gatgaagtta 1528081 tcggagaaat tattgacctt gagctggatg atcaggcgat atccatttta gaaataaaac 1528141 aggagcacgt gttcagccgg aatcagattg cgagaggaca ccatttattt gcacaggcga 1528201 attctttggc cgttgcagtc attgatgacg agctggcgct gactgcaagt gcagacatcc 1528261 gctttacaag acaggtaaag cagggtgaac gtgtcgtagc aaaagcgaaa gtgacggctg 1528321 tcgaaaaaga aaaaggaaga acggttgtcg aagtgaacag ctacgttggc gaagaaattg 1528381 ttttttctgg acgctttgac atgtatcgtt caaaacattc ataaaggtgg agcatgcatg 1528441 agaatagctg tagatgcaat gggaggagac cacgctccca aagctgttat tgacggagtt 1528501 ataaaaggta tagaggcatt tgatgatctc catatcacac ttgtcggtga caaaacaacg 1528561 atagaatcac atttaacaac tacatcagat cgcatcacgg tgctgcacgc agatgaagtg 1528621 attgagccta cggatgaacc ggtccgtgcc gtgcgaagaa aaaagaactc atctatggtt 1528681 cttatggcgc aggaggttgc ggaaaacaga gctgacgcct gcatttcagc gggaaatacc 1528741 ggtgcattaa tgacagccgg tctctttatt gtcgggagaa ttaaaggaat tgaccgtccg 1528801 gcgcttgctc cgacacttcc gactgtttcg ggagacggat ttcttctcct tgatgtcggc 1528861 gccaatgtcg atgccaaacc ggagcacctc gttcaatatg ccatcatggg ttctgtttat 1528921 tctcagcaag tgcgcggtgt cacttcaccg agagtcggac ttttaaatgt cggaacagaa 1528981 gataaaaaag gaaacgaact gacgaagcag acgtttcaaa ttttaaaaga aacagcaaac 1529041 atcaatttta tcggaaacgt ggaagcgcga gaccttttag atgatgtggc ggatgttgta 1529101 gtaacagacg gctttaccgg gaatgttaca ctcaaaacgc tggaaggctc tgcgttgtca 1529161 atttttaaaa tgatgagaga cgtaatgacg tctactttga catccaagct tgcagcagct 1529221 gtgctgaaac caaaattgaa agaaatgaaa atgaaaatgg agtattcgaa ttatggcgga 1529281 gcaagtcttt ttggcttaaa agcgcctgtg atcaaggcgc acggctcttc agattcaaat 1529341 gctgtattcc atgcgattcg gcaagcaaga gagatggtca gccaaaatgt ggctgcgctc 1529401 attcaggaag aagtgaaaga agaaaaaaca gatgagtagt ctggaggttt ttacatcatg 1529461 agtaagattg catttttatt cccgggtcag ggatcacaat ttatcggcat gggaaaagag 1529521 ctttatgagc aggtgcctgc tgcaaagcgt ctgtttgatg aagccgatga aacgttggaa 1529581 acaaaactca gctcgcttat ttttgagggg gatgctgaag aattaacact tacatacaat 1529641 gcgcagcctg ctttgcttac gacaagcatc gctgttcttg agaaatttaa agaatctggc 1529701 attacacctg atttcacagc aggacacagc cttggtgaat attctgcact ggttgcggct 1529761 ggcgctctgt ctttcaaaga tgctgtttat actgtcagaa agcgcggaga gtttatgaat 1529821 gaagcggtgc cggctggcga aggagcaatg gctgcgattc tcggcatgga tgctgaagca 1529881 ttaaagcaag taaccgataa agtcacagag gaaggcaacc ttgtacagct tgcgaatctc 1529941 aactgtcctg gccaaatcgt catttccgga acagctaaag gggttgagct tgcatctgaa 1530001 ctggcaaaag agaacggcgc aaaacgcgca attccgcttg aagtaagcgg tccgttccat 1530061 tctgaactga tgaaaccggc tgctgaaaag ctgaaagagg tattggacgc ctgtgacata 1530121 aaagacgctg acgttccggt catctcaaat gtttctgctg acgtgatgac tgaaaaagca 1530181 gatatcaaag aaaaacttat tgagcagctt tactctccgg ttcgttttga ggaaagcatt 1530241 aacaagctga tcgcagaggg tgttacgact tttattgaaa tcggtcccgg aaaagtgctt 1530301 tcaggccttg tgaaaaaagt gaatagacgg ttaaaaacaa ttgctgtatc agatccggaa 1530361 acgatcgagc tggcaattca aacgcttaag gaggagaatg ataatgctta atgataaaac 1530421 ggctattgtc actggcgcat cccgcggaat cggccgctca atcgcccttg atctggcaaa 1530481 aagcggagca aatgttgtcg tgaactactc cggcaatgaa gcgaaagcaa atgaagtggt 1530541 agatgaaatc aaatcaatgg gcagaaaagc aattgctgta aaagcggatg tatcaaatcc 1530601 cgaagatgta caaaacatga taaaagaaac attgtctgtt ttttctacga ttgacattct 1530661 ggttaataat gcgggaatta caagagacaa tctcatcatg agaatgaaag aagacgaatg 1530721 ggatgacgtc attaacatta acctgaaggg tgttttcaac tgcacaaaag ctgttacaag 1530781 acaaatgatg aaacagcgtt caggccgcat tattaacgta tcgtctatcg tcggcgtcag 1530841 cggaaaccct ggacaagcca actacgtggc tgcaaaagcc ggcgtcatcg gtttaaccaa 1530901 atcttctgct aaagagctcg ccagccgaaa tattacggta aacgcaatag cgccaggatt 1530961 tatctcaact gatatgacag ataaacttgc aaaagacgtt caagacgaaa tgctgaaaca 1531021 aattccgctc gcgcgctttg gtgaacctag cgatgtcagc agtgttgtca cgttcctagc 1531081 ttcagaggga gctcgttata tgacaggcca aacgcttcat attgacggcg gaatggtgat 1531141 gtaagttttt tctcgaaaat ttcatcgtag tttctctagt tttttaaaaa cgaatccact 1531201 ataatacttg aggggaggtg aattgctatg gcagacacat tagagcgtgt aacgaaaatc 1531261 atcgtagatc gccttggcgt tgatgaagca gacgtcaaac ttgaagcttc tttcaaggaa 1531321 gacttaggtg ctgattccct agatgtagtt gagcttgtta tggaacttga agacgagttt 1531381 gatatggaga tttctgacga agatgctgaa aagattgcaa cagtcggcga cgctgtgaac 1531441 tacatacaaa accagcaata agctgatgct aaaagtcccg ccgaaacgcg gggctttagc 1531501 cctttattcg tgcagttatt acagcatgcc gcttttacgc gcgctgtatc cggtttagtc 1531561 agagaagcgc ggtgaacctg atgtgcctat ggaggttact atgtcaaaac actcacatta 1531621 taaagataaa aaaaagttct ataaaaaagt agaacaattt aaagagtttc aagaacggat 1531681 ttcggttcac tttcaaaatg aaaagctttt gtatcaagca tttacacatt catcttatgt 1531741 gaatgagcat cggaaaaagc cgtatgaaga taatgaaagg cttgaatttt taggtgacgc 1531801 tgttttggaa ctgacgatct ccagattctt atttgccaaa tacccggcta tgagtgaagg 1531861 agatttgacg aaattgagag ccgcaattgt ttgcgaaccg tctctcgttt cattggctca 1531921 cgagctgtca ttcggcgatc ttgtcctgtt gggtaaaggc gaggaaatga caggcggaag 1531981 aaagcgtcct gctctattgg cggatgtttt tgaggcattt atcggagcct tgtaccttga 1532041 ccaaggatta gagccggtcg aaagtttctt aaaagtttat gtgttcccta aaattaacga 1532101 tggtgctttt tctcatgtga tggatttcaa aagccagctg caggaatacg tgcagcggga 1532161 cggcaaaggc tctctggagt ataaaatctc caacgaaaaa ggacctgcgc acaaccgtga 1532221 atttgaagcc atcgtatctc taaaaggtga accactcgga gtcggaaacg gccgttcaaa 1532281 gaaagaagcc gaacagcacg ctgctcagga agctttagct aaattgcaaa aacaccatac 1532341 gaaacaataa aatccccctt atgactcagg gggatttcag tatgtatgcc gtcttatttg 1532401 accaatgttt atgatagaat tgaaatactt attacataag gaggatcgct atgttcctca 1532461 aacgtttaga cgttatagga tttaaatcat ttgcagaacg gatttccgta gacttcgtta 1532521 aaggcgtgac agcagttgtc gggccgaacg gaagcggaaa aagcaacatc acggatgcca 1532581 ttcgctgggt tctcggcgaa caatcggcac gctctcttcg cggcggaaaa atggaagaca 1532641 tcatttttgc tgggagtgat tcaagaaagc gattaaatct agctgaagtt acgcttactc 1532701 ttgataatga tgatcatttc ttgccaattg acttccacga ggtgagtgtc acaagacgtg 1532761 tgtacagatc aggtgagagt gagtttctga ttaacaatca gccatgccgc ttgaaagata 1532821 ttattgattt atttatggac tctgggcttg gtaaagaagc attttctatt atcagccaag 1532881 ggaaagtgga agagatcctg agcagcaaag cggaggatcg ccgcagtatc tttgaagaag 1532941 cggccggggt gcttaaatat aaaacgagaa agaaaaaagc agaaaataaa ctgtttgaga 1533001 cacaggacaa tctaaatcgg gtagaagata tattacatga gcttgaagga caggttgaac 1533061 ctcttaaaat tcaagcttca atagcgaaag actaccttga gaaaaagaaa gagctggagc 1533121 atgttgaaat tgcgctgact gcctatgata tcgaagagct gcatggtaaa tggtcgactc 1533181 ttaaagagaa agtgcagatg gcaaaagaag aagagcttgc tgaatcgtct gctatttctg 1533241 cgaaagaagc aaagattgag gatacaaggg acaaaataca agcgcttgat gagtcagtag 1533301 atgagctcca gcaagtttta ctggtaacta gtgaagagct ggaaaagctt gaaggccgta 1533361 aagaagtcct gaaagaacga aagaaaaacg ctgtgcaaaa ccaagaacag cttgaagaag 1533421 ccatcgttca gttccagcaa aaagaaacgg ttctgaaaga agagctttcg aagcaggaag 1533481 ctgtcttcga aacgcttcag gctgaggtga agcagttaag ggcgcaagta aaagaaaaac 1533541 agcaggctct cagtcttcac aatgaaaatg tcgaagagaa aatcgagcag ctgaaaagtg 1533601 attattttga gctgttaaac agccaggctt cgatacgcaa cgaactccag cttcttgatg 1533661 accagatgtc ccaatccgct gtcacattgc agagacttgc ggacaacaat gaaaagcacc 1533721 tgcaggaacg gcatgatatt tctgcgcgta aagccgcatg tgaaacggaa tttgcccgaa 1533781 ttgagcagga gattcacagt caagtcggtg catatcgtga tatgcagaca aaatatgagc 1533841 agaaaaagcg ccaatacgaa aaaaatgaat ccgctctgta tcaggcatac caatacgttc 1533901 agcaagcgag atcaaaaaag gacatgcttg agacgatgca gggagatttc tccggctttt 1533961 atcaaggtgt taaagaagtg ctgaaagcga aagagcgcct tggcggaatt cgcggagcgg 1534021 ttcttgagct gatttctaca gaacagaagt atgaaacggc cattgaaata gcgctcggcg 1534081 cttctgctca acacgtcgtg accgacgatg aacaatctgc ccgcaaagcg attcaatatt 1534141 taaagcagaa ttccttcggc cgggcgacgt ttctgcctct ttctgttatt agagaccgcc 1534201 agcttcaaag ccgtgacgcg gaaacagccg cccggcattc atcatttctc ggggttgcca 1534261 gtgaacttgt cacatttgat cctgcgtatc gaagcgtcat ccagaatctt cttggaaccg 1534321 ttctgatcac agaggactta aagggtgcaa acgagcttgc gaagcttctc gggcaccggt 1534381 accgcatcgt aacccttgag ggagatgttg tgaaccccgg tggttcaatg acgggcggcg 1534441 cggttaaaaa gaaaaataac tccctccttg gaagaagccg ggagctagaa gatgtgacga 1534501 aacggctcgc tgaaatggaa gagaaaacgg cactgcttga acaagaggtc aaaaccctta 1534561 agcactccat tcaggatatg gagaaaaaac tggctgactt aagagaaacc ggggaaggct 1534621 taaggttaaa gcagcaggat gtgaaaggcc agctgtacga acttcaagtt gccgagaaaa 1534681 atatcaatac ccatttagag ctctatgatc aagaaaaatc tgctctgtca gaaagcgatg 1534741 aagagagaaa agtgcgcaaa cgcaagcttg aagaagagct ctctgccgta tctgaaaaga 1534801 tgaaacagct tgaagaggac atagacagac tgacaaaaca aaaacaaacg caatcctcaa 1534861 cgaaagagtc tctctccaac gagctgactg agctgaagat cgcagcggcc aaaaaagagc 1534921 aggcttgcaa gggggaagag gacaaccttg ccagattaaa gaaagagctc actgaaacag 1534981 agcttgcgtt aaaagaagca aaagaagact taagcttctt aacgtcagag atgtcatcta 1535041 gcaccagcgg cgaagaaaag ctggaagaag cagcaaaaca taaattgaat gacaaaacga 1535101 aaacgatcga actgattgca ttaaggcgcg atcagcgcat caagcttcag catgggcttg 1535161 atacgtatga gcgtgagctg aaagaaatga aacgcctgta taaacaaaaa acaacgctct 1535221 taaaagacga agaagtcaaa cttggacgaa tggaagtcga gcttgataat ttactccaat 1535281 acttacggga ggaatacagc ttgtcctttg agggggcaaa agagaaatat cagcttgaaa 1535341 ctgatccaga ggaagccaga aagcgcgtga agctgattaa actcgcaatt gaagagctgg 1535401 gtaccgtgaa cctcggaagc atagatgagt ttgagagggt caacgaacgg tacaagtttc 1535461 tgtcggaaca aaaagaagat ttaacagaag cgaaaaatac cttgttccaa gtgattgaag 1535521 aaatggatga agaaatgacg aagcgcttta acgacacatt cgtccaaatc cgctcacact 1535581 ttgatcaagt tttccgctcc ttattcggag gagggcgagc tgaactgagg ctcaccgatc 1535641 ctaacgatct gcttcattca ggagtcgaga ttatcgctca gccgccgggg aaaaagctgc 1535701 aaaacttaaa cctcctgtca ggcggagagc gtgcgcttac tgctatagcg ctcttattct 1535761 caatcctaaa ggttcgtcca gtgccgtttt gcgtccttga cgaagtagag gctgcgctcg 1535821 acgaagcgaa tgtgttccga tttgcgcagt atttaaaaaa atacagcagc gatactcagt 1535881 ttattgtgat tacccacaga aaaggaacga tggaggaagc ggatgtgctt tatggcgtaa 1535941 ccatgcagga atccggtgtt tccaaggtaa tttcagttaa gctggaagaa acaaaagaat 1536001 tcgttcagta acgaggaaag aggttaaaag atgagctttt ttaaaaaatt aaaagagaaa 1536061 atcacaaaac agacagattc cgtatctgaa aagtttaagg atggccttga aaaaacaaga 1536121 aactcctttc aaaacaaagt gaatgatctt gtatcccgtt accgtaaagt ggatgaggat 1536181 ttcttcgaag agcttgaaga ggttcttatc agcgcggatg tcggttttac aaccgttatg 1536241 gaattaatag atgagctgaa aaaagaagtc aaacgcagaa atattcaaga tccaaaggaa 1536301 gtccagtcag tgatttctga gaaactggtc gagatttata acagcggaga tgagcaaatt 1536361 tcagaactga acatccagga tgggcgttta aacgtaatcc ttctggtagg tgtaaacggc 1536421 gtcgggaaaa caacaacgat cggaaagctt gctcataaaa tgaaacaaga aggaaaatct 1536481 gttgtacttg ccgccggaga cacttttaga gcgggagcca ttgaacagct ggaagtatgg 1536541 ggagagcgta caggagtgcc tgtcattaag cagacggcag gaagcgatcc ggcggctgtc 1536601 atctacgatg ctgttcatgc tgcgaaagca agaaatgccg atgtattaat ttgtgatacg 1536661 gcagggcgtc tccaaaacaa agtaaatctc atgaaagagc ttgaaaaagt aaaacgtgtt 1536721 atcgaaagag aagttcctga agctccgcat gaggtgctgc ttgcccttga tgccacgacc 1536781 ggccaaaatg caatggctca ggcaaaagaa ttctctaaag caacaaatgt taccggcatt 1536841 gctttaacga agcttgacgg tacggcaaaa ggcggtatcg tccttgcgat tcgcaacgag 1536901 cttcacatcc cggttaaact agtcggttta ggagaaaaag ttgatgacct tcaggaattt 1536961 gatccagaat cctatgtgta cggactcttt tcagatttag tggaaaaagc cgacgattaa 1537021 gaaaaaggcc ccaacatctt ggggcctttt tcttttttat cttcttactt gataggcgaa 1537081 atgataaagg ctgttatcag tggataccag tcttgactca ccagaaaaaa ctctgaatgg 1537141 gatgatgtca tagtaatgaa cggaaacaga tgtgtaatac gtatagtaac cagcagctgg 1537201 ccccaaatac attggaacct caaatgttcc gtttgcatca gtcgttcctg aagcagtttg 1537261 tgttgtgttt ccgaccttcg tgtccgcttc aaatcttacg ggcgcgtttg gcactggctg 1537321 tccgttttgg tcgagtaatt tgccgcttac tgtaatattg tacttgactc gccaatattg 1537381 accttgtccg taattgattt taccgtatac ccctccatct gtgctgatat ttgtgattga 1537441 ggccttataa ggtgcctcag cagcgtctgc ttgctgtgcc gggaaaccta ttgtaaacag 1537501 ggctgccaga cataacataa acaataaacc gatttttttc ataaaaatcc tccttaaaat 1537561 agggttcata tacaatatcg gaataaattg gatgatattt agcgtatttt ggaaaagtta 1537621 atcgccgctt tgacaagata aaaacttgac agtgtcatta aaaccgtgta aactaagtta 1537681 tcgtaaaggg atttgactta acaaagggga gagctcaaat gtcactcgaa aagacaacga 1537741 gaatgaatta tctgtttgat ttttatcagt cgttgttgac gtcaaaacag aagagctata 1537801 tgtcgcttta ttatttggac gatttctccc taggcgaaat agccgaagaa tatgaggttt 1537861 caagacaagc tgtttatgat aacatcaaac gaacagaagc aatgcttgaa caatatgaag 1537921 aaaagctgct ccttttgaaa aagtttcagg agcgtaaaga gatgtttaat aagctgaagg 1537981 agcttgcttc cggttcaaaa gaagaggaag aaattacagc tctgattgaa gcgcttgaga 1538041 aattagatta ggaggcggca aactatggca tttgaaggat tagccgaccg actgcagcag 1538101 acgatttcta aaatccgcgg aaaagggaaa gtcagcgaac aagatgtaaa agagatgatg 1538161 cgtgaggtcc gtcttgcgct gcttgaggct gacgttaact ttaaagtagt caaggatttt 1538221 gtcaaaaaag taagtgaacg cgctgtaggc caagacgtca tgaaaagtct gacgcccggc 1538281 cagcaggtca ttaaagttgt tcaagaggaa ctgactgagc tgatgggcgg cgaagagagc 1538341 aaaatcgccg tcgcaaaaag gccgccgact gttattatga tggtcggtct ccaaggtgcc 1538401 ggtaaaacga caacaagcgg taagcttgcg aatctgctgc gcaaaaagca taatcgcaaa 1538461 ccgatgctgg ttgctgccga tatttaccgc ccagccgcaa ttaagcagct ggaaacactc 1538521 ggcaaacagc ttgatatgcc tgttttctct cttggcgatc aggtcagtcc tgtagaaata 1538581 gctaaacagg ctattgagaa agccaaggaa gaacattatg actacgtcat tttggatacg 1538641 gcagggcgct tgcatatcga ccatgaactg atggatgaac tgaccaacgt caaagaaatc 1538701 gcgaatccgg aagaaatttt cctggttgtc gattcaatga ccggtcagga cgctgtgaat 1538761 gttgccaaaa gctttaatga acagctcggt ttaaccggtg ttgtgttgac taagctggat 1538821 ggagacacac gcggcggggc tgcgctttct attcgcgctg tcacaaacac gccaattaag 1538881 tttgcaggtt tgggcgaaaa gcttgatgcg ttagagccgt tccatcctga acgcatggca 1538941 tcaaggattc tcggcatggg cgacgtgctg acattgattg aaaaagcaca ggccagcgtt 1539001 gatgaagaca aagccaaaga gctggaacaa aaaatgagaa cgatgagctt cacattggac 1539061 gattttctgg agcagctcgg gcaagtcaga aacatggggc cgcttgatga gcttctgcaa 1539121 atgatgccgg gtgcaggtaa aatgaagggc ctgaaaaaca tccaagttga tgaaaaacag 1539181 ctgaatcatg tggaagcaat catcaaatca atgactgttc ttgaaaaaga acagccggat 1539241 attatcaatg ccagccggcg gaagcggatt gcaaaaggaa gcgggacatc cgtacaggaa 1539301 gtcaaccgtc tgcttaagca gtttgatgaa atgaaaaaaa tgatgaagca gatgacaaac 1539361 atgtcaaaag gcaagaaaaa agggtttaag ctacctttta tgtaatcggt tatacatgat 1539421 aaaaccgttg ttaagaaaaa acactttaca aacactttta tcattgttaa tatactatct 1539481 tgttgaaata ttttcggagg tgctagtaaa atggcagtaa aaattcgttt aaaacgtatg 1539541 ggagcaaaaa aatctccttt ctatcgtatt gttgtagcag attctcgttc accacgtgac 1539601 ggccgtttca tcgaaacagt cggaacttac aacccggttg caaaaccagc ggaagtaaaa 1539661 attgacgaag agcttgctct taaatggctt caaactggag cgaaaccatc tgatacagtt 1539721 cgcaacttgt tctctagcca aggaatcatg gaaaaattcc acaacgctaa acaaggcaag 1539781 taatgactga tcaacacttg gaagatttga ttgtccacat tgtgacgccg cttgttgatc 1539841 atccagatga cattcgcgtc ataagagaag aaaccgatca aaagattgcg ctgcgcttat 1539901 ctgtccataa gtcagatacc ggtaaagtta tcggaaagca aggccggact gcaaaagcga 1539961 ttcgaacagc tgtatttgca gctggcgtac agtcttctaa gaaagttcaa tttgaaatat 1540021 ttgactaaaa gggagagggc cggcacctcc ccttttttta cacgcaaaaa aagggtaaac 1540081 tgatagaagc ttaggcaaaa tagaaaagcc tggacgagta aaagttttaa aagcggggag 1540141 cttggtgcga tgcaaattat tcaccgtgta gccgttatgc aagtcttaac cgagcgcagt 1540201 aaagaaaagc ttttagcttc ttttgctgag aagaaacaaa tgcttgaacg agaatgcagc 1540261 cagctctatt ttcagcttag aaaacatgag aaagaacagc aaaaccctaa tatgattgaa 1540321 caatttaaaa aggcaataga aaagcgaaaa gatgatataa aaatcattga ttttcaaatt 1540381 gctcaagtac atacattgcc gcttggcagt gagttgaaag aaaaggaagt cgatgcgctg 1540441 ctgacgattg aagccgggga tgactggcat gagaaaacag cagcgaacac catcgtcata 1540501 aaagacggaa aagtaattga aattcgccag aggtgatcat atgacaaagc gatggtttaa 1540561 tgtaggcaaa atcgtaaata cccacggaat caaaggcgaa gtgcgggtga tttcaaaaac 1540621 agattttgcc gaagaacgat acaagccggg aaacacgctg tatttgttta tggacggccg 1540681 taacgaacca gtggaggtaa cggtaaacac acatagactg cataagcaat ttcatctcct 1540741 gcagtttaaa gaaagacaaa acctaaatga agtagaagag ctgaaaaacg caatcattaa 1540801 agttcctgaa gaagaattag gagagctgaa tgagggtgaa ttttatttcc acgaaattat 1540861 tgggtgtgaa gtatttactg aagaaggcga actcatcgga aaggtcaaag aaattttgac 1540921 gcctggagcc aatgacgttt gggtcatcgg acgaaaagga aaaaaagacg cactcattcc 1540981 ttacattgaa tcagtggtta aacatatcga tgtcagggaa aagaaaattg agattgaact 1541041 catggaaggg ttaatagacg aatgaaaatc gattttttga cgctgtttcc cgaaatgttt 1541101 gaaggcgtgc tcggctcatc gattcttcaa aaagcccagg aaaaagatgc ggtgcagttt 1541161 caagtcgtaa atttccgaga gtactctgat aacaagcaca atactgttga tgattatcct 1541221 tatggcggcg gggcaggcat ggttctcaag ccccagcctg tttttgacgc ggtcgaggac 1541281 ctgacatcaa aggcagccgc tgctccgcgt attatcctcg tatgcccgca aggtgagcgt 1541341 tttacccaaa aaaaagccga acaattagct aaggaagagc atttgctgtt catttgcggc 1541401 cactatgaag gctatgatga acgcattcgc gagcacttgg taacggatga aatatcaatt 1541461 ggcgactttg ttctgacggg cggtgagctc cctgcaatga tgatcgcaga cagtgtggtc 1541521 agactgcttc cgggtgtact gggtaaagag gcttcccata ttgaggattc cttcagcacc 1541581 ggacttttag agcacccgca ttatacaaga ccggcagatt acaaaggttt aaaagtgcct 1541641 gaaacactct tgtcaggaaa ccatgcaaaa attgaagaat ggcggaataa agaatcgatc 1541701 agaaggacct acctaagacg tccggatctg ttgaaagacc acccgcttac agagcagcaa 1541761 agaaagtgga tttctgaatg ggaaaaagaa tagattttat tgcataggct atgaaattgt 1541821 gataagatac tacttgtggc ttaagcgggc ttatccgctg caagcttgaa aacgatgttc 1541881 cgctgtgccg gtttttgtgg ccaagagcat ctgttggaag gagttgaaaa cgatgcaaaa 1541941 actaattgaa gatatcacaa aagaacagct tcgtactgat cttcctgcgt tccgtcctgg 1542001 tgacacttta cgtgtacacg ttaaagttgt tgagggtaac cgtgagcgta tccagatctt 1542061 tgaaggtgtt gtgattaagc gtcgtggtgg tggaatcagc gaaacgttca cagttcgtaa 1542121 gatttcttac ggtgttggcg ttgaacgtac tttcccagta cacacaccaa aaatcgcgaa 1542181 aatcgaagtt gtacgttacg gtaaagtacg ccgtgctaaa ctttactacc tgcgtgaact 1542241 tcgcggaaaa gcggctcgta ttaaagagat cagacgataa tgataacgaa cgaaaagagc 1542301 ttgttacctg taacaagctc tttttttata cagaatttga aaatgccgga caggcatcgt 1542361 aaaatacata aaggacaaca atgaatcatg catactgaag ataaaggcgg tgttcgtgtc 1542421 acatgacaat tcaatggttc ccgggccata tggcaaaagc aagaagggaa gtaaccgaaa 1542481 aattaaaatt aatcgatatc gtatatgaat tggtagatgc cagaattcca atgtcatcaa 1542541 gaaacccaat gattgaagat attctaaaaa acaagccgcg aattatgctg ttaaacaagg 1542601 ctgacaaagc agatgcggca gttacacagc agtggaaaga gcactttgag aaccagggga 1542661 tccgctctct gtctattaat tctgtaaatg gacaagggtt aaatcaaatt gtgcctgcat 1542721 caaaagagat cctccaagaa aaatttgacc ggatgcgtgc gaaaggtgtg aagccgagag 1542781 cgattcgcgc tttgattatc ggcattccaa acgtcggaaa atcaacgctc atcaaccggc 1542841 ttgcaaagaa aaacatagca aaaacgggag acagacctgg tattacgact tctcaacagt 1542901 gggtcaaagt tgggaaagaa ttagagctat tagatacacc gggaattttg tggcctaaat 1542961 ttgaggatga gcttgtcggt ttgagactgg cagtcaccgg ggctattaaa gactcgatta 1543021 tcaatttgca ggacgtggcc gtgtttggtc ttcgttttct cgaagaacat tacccagaac 1543081 ggcttaaaga gcgttatggc cttgatgaga tcccagagga cattgccgag ctgtttgatg 1543141 caataggtga aaagcggggc tgtctcatga gcggtgggct catcaactac gataagacga 1543201 ctgaagtcat cattcgcgat attcgcactg aaaagttcgg caggctgtca tttgaacagc 1543261 cgacgatgta aaggcgcgca gaaatgcggg tctttatttt ttcttggctg aaccgataca 1543321 tacagtaagg gagaagagaa agtgaataca ttaaccgtaa aggacattaa agaccgtttg 1543381 caggaagtga aggatgcaca agacccattt attgcccaat gcgaaaacga cccgagaaaa 1543441 agcgttcaaa cgcttgtaga gcaatggctt aaaaagcaag cgaaagaaaa agcgctgaaa 1543501 gaacaatggg tgaatatgac ttcctatgaa aggctggcaa gaaacaaagg atttcgcttg 1543561 attgcaggtg ttgacgaggt cggccggggg ccattggcag gaccagttgt cgccagcgca 1543621 gtcatccttc cagaggaatg tgaaatactt gggctgacag actccaaaaa gctttcagag 1543681 aaaaaacgcg aggaatatta cgagcttatt atgaaggaag cactggcggt cgggatagga 1543741 attgtagaag ctactgtgat tgatgagatc aatatatatg aagcttcaaa aatggcaatg 1543801 gtgaaagcga tacaggattt gtcggataca cctgattatt tgcttgttga cgcaatgaca 1543861 cttccgctcg acacggctca ggcgtcaatt ataaaaggcg atgccaaaag cgtgtctatt 1543921 gcggcaggtg cgtgtatcgc aaaagtgacg agggaccgaa tgatgagcgc ttatgccgaa 1543981 acgtatccca tgtacggctt tgaaaaaaat aaaggctatg ggacaaaaga acatttggaa 1544041 gctctcgctg catacggccc aactgaattg caccgcaaaa ctttcgctcc tgttcaatct 1544101 ttcagataaa tcaccatgga caaggaggca cctttttaaa atgaacatac gaaatgatgt 1544161 gcaaaaggcg ctgcagcacc ttttcgggcg tacagccgtc ccgcaggaaa catcaaaagt 1544221 aaacgaagcg ctaaacgggg agaagcgtct cctcttagga aaagtgcttc gtttactagg 1544281 agatcagcat gccctgatcc aagtcggcaa tcaaactgtt cagggaaaac ttgaaactca 1544341 gcttcgtcct caggcatact attggttttc ctacgaaaaa aaaacggcag agcaaacagg 1544401 ccgtcttcag gtcgttcaaa gctttgatca aaatcctaaa accattcagg atgcagctgg 1544461 caaactttta aatgctattt cagtgaagac gtcaaacgca gctctcatga tgacaggagc 1544521 gatgctgaaa agcaaaacac ccgtaacaga aaatgatatc aaaacagctg tccgctggat 1544581 ggacacgctg ccttcgcaag acacaaaaaa agcagttgaa acggttctct tcgctttaaa 1544641 gcgtgatctt cccattcact ccgagatttt gaatggtgtt cacgctgtga aatcgcctgt 1544701 tccgttgcat cagcacgtat cccagctgct acaggcaatc gaccaaaacc ctcagcagag 1544761 ccaaatgatg tcaaagctaa aggaagcagt cacggtgctt ttaaatagtg aaatcgatgt 1544821 ccatgcagaa cggctgattg ataagcttat ttctttaacc gacaatacga aagcaccttc 1544881 tccgacgaat acagctggaa gcagggagct tagcacacca gctggctccc ccggaaaagc 1544941 cagcctgccg attgcaaatc acacagcaga acagggaagc atacaagaag agcctgttaa 1545001 aacagcagca gacattccaa ttaaagaagc ccgccagctg ctggtgaagc tgacggaatc 1545061 tgctgaaaaa aacagtctcc aaattgtgaa agaagcagca aattggatta aagcggctgc 1545121 ttcatcgggt gatagtaagt cacttgcagc ttcagctgtt ttacaggcgg cacaagtcac 1545181 agatcaggaa gccgaagtct ttttaaaggc tgttcagcag acagcacccc atttggcgga 1545241 taaggcagat gttctttctt tcttatccaa agtgaaaacg gcaatcggcg caagggacga 1545301 ggttgcgttc attaaagcgt ttgaacaagg aagcgcagtc acatctggcg aaatgcaatc 1545361 catcaagctg gctctttctg ccttaagagc atcgcatgag gtagccgaac cagtcaaaca 1545421 agaagccgat cagctttttc ataaattaaa tggccagctt ttcatgcagc aggaccatcc 1545481 atcatacagc caaattgtaa tgtcatttcc gatgttttcg aagtcagggg ttcaggacat 1545541 gactgttctg tttaaaggaa agaaagaagc ggatggaaag cttgatcctt cccattgccg 1545601 ccttttgttt ttgctgcagc ttgatacact aaaagaaacc gtcgttgatt gcttggtaca 1545661 gcaaaaagtc atgaccatta caatagagac tgatttcgag ctgcaggctg cgatcgatcc 1545721 gatggtgccc gcgcttaaac aggggctaaa ggaaatgggg tacagccttt caggggtaaa 1545781 cgctaaaaaa agggttcaca ccgaagaaaa ggcttcaatc gatcaatata taacaagtat 1545841 cagtgatcag gaagtggatg tgaaaatatg aaagagcaga caccgatcag aaaagctgtt 1545901 gctctccatt atgacgaaca aaaagacaag gcgccgagag tgattgccac agggaagggc 1545961 catgtagctg acaacattat aaaagaagcg aaaaaagcag gggtcccgat tcaagaagat 1546021 cggacccttg tcgaattaat gcgccatttg acggtagatg atcaaattcc tgaagctctt 1546081 tatgaaacgg tagccgagat tttttcattc atttacaaat tggacgaaag cgtaaaaaac 1546141 aaaaaatagc taaaatattc cccatccttc tttgaaattt atgtttttaa taaagtaaaa 1546201 gtttgaatgt ttagaaggat taaaagattt tgcatcgaac tgtagacaat tcttccagta 1546261 ttattataga atgaaagcgc agtctatttt agttttgtta cataagttag gaggatggga 1546321 aatgaatatc catgagtacc agggaaaaga agtcctcaga aaatatgggg tatctgttcc 1546381 tgaaggtaaa gtggctttta cagcagaaga agcagttgag agtgcaaaga gcttatccag 1546441 ctcggtttat gtcgtaaagg ctcaaattca tgctggcggt cgaggcaaag ctggtggggt 1546501 aaaaatagca aaatcattag acgaagtaaa agcgtatgcc gaagaactat tagggaagac 1546561 cctagttaca catcagacgg gtccggacgg ccaagtaata aaacgcttac ttattgaaga 1546621 aggctgcgat attaaaaaag aatattacat cggtctagtg cttgaccgcg ccacttcaag 1546681 aatcgtttta atggcttctg aagaaggcgg aacggaaatt gaagaggttg cggagaaaac 1546741 accagaaaaa atcaaaaaag ctgtcattga tccagctgtt ggccttcaag gctatcaagc 1546801 cagagaaatt gcattcgcta ttaatattcc aaaagagctc gtgggaaaag ctgctaaatt 1546861 tatgcttgga ctatataaag cgtttgttga gaaagactgc tcaatcgccg aaatcaatcc 1546921 gcttgttgtg actggcgacg gaaatgtgat ggcgcttgat gcaaaattga attttgacag 1546981 caatgcgttg taccgacaaa aggacattat ggaatacaga gatttggatg aagaagatcc 1547041 gaaagaaatt gaagcgtcca aatatgatct aagctacatt tcccttgatg gaaatatcgg 1547101 ctgtatggta aacggcgcgg gacttgcaat gtctacgatg gatattatca agcattatgg 1547161 aggagaaccg gccaacttcc ttgatgtggg cggcggtgca accgcggaaa aagtcacgga 1547221 agcatttaaa atcattcttt ctgatcaaaa cgttaaaggg atttttgtca acattttcgg 1547281 cggcattatg aaatgtgatg tcatcgcaga aggggttgtt gaagcgacta gacaagttgg 1547341 tttgacattg ccgcttgtcg tccgtcttga aggcacaaac gtggatctag ggaagaaaat 1547401 ccttagtgaa tcaggattaa acattacatc tgcggaatca atggctgacg gcgcgcagaa 1547461 aatcgtatcc ttagtttaag aaagaatgaa aggcagggga ccaaataatg agtgttttca 1547521 ttaataaaga tacaagagtt attgtgcaag ggattacagg ttctaccgct ttatttcata 1547581 cgaagcagat gcttgaatac ggcacaaata tcgttggcgg tgtaacacct ggaaaaggcg 1547641 gaacagaagc ggaaggtgtt cctgtattta atacagtggc tgaagcagtt caaacaaccg 1547701 gcgctaacgc gtctgttata tatgtgcccg caccgtttgc agctgatgcg attatggaag 1547761 cggtagatgc ggagcttgat ctcgtgattt gtatcacaga acatatcccg gttttggata 1547821 tggtgaaggt caaacgcttc atggaaggca agaaaacgag actgataggg ccgaactgtc 1547881 ctggtgtcat tacgcctgaa gaatgtaaaa tcggcattat gcccggatac atccataaaa 1547941 agggtcatgt aggcgttgta tcacgttcag gaacattaac atacgaagcg gtgcaccagc 1548001 tctcagaagc gggtgtaggg caatctacag ctgttggaat cggcggcgac cctgtaaatg 1548061 gaacaaactt tattgacgtt ttaaaagcgt ttaacgaaga tcctgacaca cacgcagtca 1548121 tcatgattgg cgaaatcggc ggtacggccg aagaggaagc ggcagagtgg gtaaaagcca 1548181 acatgacaaa accggtagtc ggttttattg gcggtaaaac agcacctcct gggaagcgca 1548241 tggggcatgc aggcgccatt atttccggcg ggaaagggac agctgatgaa aaaatcaaaa 1548301 cccttaatgc atgcggaatc gaagttgcag agacaccttc tgtcatgggt gaaaccttaa 1548361 tcaaggtgct gaaagagaag aacttgttcg aaacttgtaa aacgcattaa taaaaaaggg 1548421 acagccgtca aggctgttcc tgctttttct aacaaaagga ggtcaatcta ttggatcagg 1548481 ccgctgtctg cctaacgatt tgcagaatca atcaattatt atccccatcc cttctattaa 1548541 aatggtggaa agccgatccg tctatgtcgc tgacatcacc cgtgttacaa acggttactc 1548601 gtgatcaaat aaaagcagct gcattaaaaa acgaaataga acaattttat ccaaagctcc 1548661 cgcgtgtact tgctgcttat cgtgagcaag gcattaacac catccctatt tcttcaaagc 1548721 aatatccttt ctggcttaaa agcatttatg atccccctgc cgtactgttt gcaaaaggtg 1548781 atatgactct tctttcgaaa gggagaaaaa ttggaattgt aggcacaaga aatccaacag 1548841 cttatgggaa acaagttgtc aatcatctta caaaagagat ctgtcgtaaa ggttgggtga 1548901 ttgtcagcgg actggcgtct gggatagacg gaatgtccca tgctgcaagt attaaggcga 1548961 aggggcggac aattggcgtc attgcaggcg gatttcaaca catttatccc cgagaaaacc 1549021 ttcagttagc agatcacatg gctaaacacc atatcctgct gtcagagcac ccacctgaaa 1549081 ctaaacccca aaaatggcat ttccctatga gaaaccgtat tatcagcgga ctaagtgaag 1549141 gcgttattgt cgttcagggc aaagaaaaaa gcggttcgct gattactgcc tatcaagcat 1549201 tggaacaagg gagagaggta tttgccgtac ccggttcatt gtttgaccct tacgccggag 1549261 gtcctataaa actgatccag cagggggcta aagccatatg gtcagcagag gatattttcg 1549321 aggaacttcc tgagagaaac gttcaatata cggaaccctt ttgaattatc gtttgacaaa 1549381 cggtattgta atatttaata atagtgagga tttaaagttg catattgttt tctatttaat 1549441 taatgacgtt catgataaag aatgaaatgt tgaaagccaa ataaagacag ctgcaaaaat 1549501 aaaattgaaa tatcttgaaa agagagagaa cacctcttga gggggatgaa aatgtctgat 1549561 tatctagtca tcgtggaatc gcccgctaag gcgaaaacga ttgaacgtta cttaggtaaa 1549621 aaatataaag taaaagcatc aatgggacat gtccgggatc ttccaaaaag tcaaatggga 1549681 gttgacatag aacagaattt tgaaccgaaa tatattacca ttcgaggtaa aggcccggta 1549741 ttaaaagagc tgaaaacggc tgcgaaaaaa gccaaaaaag tgtatctcgc agctgacccc 1549801 gacagagaag gggaagcgat tgcatggcat ttggcacaca gtcttgattt agatctcaac 1549861 tcagactgcc gtgtggtgtt taacgaaatt acaaaagacg ctattaagga atcgtttaag 1549921 catccccgca tgatcaatat ggatttagtg gatgcacagc aagcgagacg tattttagac 1549981 aggcttgtcg gatataaaat cagtccaatc ttatggaaaa aagtcaaaaa agggcttagc 1550041 gcaggacgcg tgcaatccgt tgccctccgt ttgattattg accgtgaaaa agagattaac 1550101 gactttaagc ctgaggaata ttggacaatt gacggtacgt tcttaaaagg tcaagaaacc 1550161 tttgaagcga gctttttcgg gaaaaacggc aaaaaacttc ctttaaatag tgaagctgat 1550221 gtaaaagaga ttctttctca gctcaaaggg aatcaatata cagttgaaaa agtaaccaaa 1550281 aaggaacgca aacgtaatcc tgctttgcct tttaccactt ctaccctgca gcaggaagcg 1550341 gctcgcaagc tcaatttcag agcgaagaaa acgatgatga ttgcacagca attatatgaa 1550401 ggaattgatt taggaagaga aggaacggtt ggtctgatca cgtatatgag aacggattca 1550461 acccgtattt caaatacggc tgttgatgaa gcagctgcat ttattgatca gacatatgga 1550521 aaagagttcc taggcggaaa acggaagcct gcgaaaaaga atgaaaatgc ccaggatgcc 1550581 cacgaagcaa ttcggccgac atcagttctt agaaaaccaa gtgaattaaa agcagtcctc 1550641 ggcagagacc aaatgagact gtataaatta atttgggagc gttttgttgc cagccaaatg 1550701 gcaccggctg ttctcgatac aatgagtgtc gacctgacaa acaacggttt gacatttcgt 1550761 gcaaatggaa gtaaagtcaa gttttccggg tttatgaagg tgtatgttga aggaaaagac 1550821 gatcaaatgg aagaaaaaga ccggatgctg cctgacttac aagaaggcga cacggtatta 1550881 tcaaaagata tagaacctga gcagcatttt acccagccgc ctccgcgata tactgaggcc 1550941 cggcttgtta aaacccttga agaacgcggt atcggccgtc catccacata tgctccgaca 1551001 cttgatacta ttcagcggcg cggctacgtg gcattggata ataaacgttt cgttccgact 1551061 gaattaggtc agatcgttct tgacttgatc atggagtttt tccctgagat cattaacgtt 1551121 gagtttacag ctaaaatgga gagagatctt gatcatgttg aagaaggaaa taccgaatgg 1551181 gtcaagatta tcgataattt ctacaccgat tttgaaaaac gcgtcaaaaa agccgaatcg 1551241 gaaatgaagg aagttgagat tgaaccagag tatgctggag aggattgtga attgtgcagt 1551301 tctccaatgg tatataaaat gggacggtac ggtaaattct tagcttgctc caacttccct 1551361 gactgccgga acacgaaacc gattgtgaaa caaatcggtg tgaagtgccc gagctgcgga 1551421 gaaggaaaca ttgttgagcg aaaatcgaaa aagaaacggg tgttttacgg ctgtgaccgt 1551481 tatccggact gtgaattcgt atcatgggac aaaccaattg aacgaaaatg cccgaaatgc 1551541 ggaaaaatgc tcgtcgagaa aaaactcaaa aaaggtatac aagtccaatg cgtggaatgc 1551601 gattataagg aagaaccaca gaagtagcgg tgagcagggt cttgctcacc ttctttgtgt 1551661 gttaaaagaa ggccttgaat aataaactag gagatgtgaa agatgaacca acaaacagtg 1551721 aatgtaatcg gagccggact cgcaggaagt gaagcagcat ggcagcttgc caaacgtggg 1551781 attcaagtca aattgtatga aatgcggcca gttaaacaaa cgcctgcgca tcatacagat 1551841 aaatttgctg agcttgtctg cagcaactct cttcgctcta atacacttgc taacgctgtc 1551901 ggtgtattaa aggaagaaat gcgtgcgctt gattcagcca ttatcgctgc ggctgacgaa 1551961 tgttcggtgc ctgccggggg cgctcttgca gtagaccgtc atgaatttgc cgcaagtgtg 1552021 acaaatcggg tgaaaaatca tccaaacgta accgttatta atgaagaagt gactgaaatt 1552081 cctgaaggcc ctactatcat cgcaacgggt ccgttaacat ctgaatcgct gtctgcccag 1552141 ctgaaggagc tgactggaga ggactattta tatttttatg acgcagcggc gccaattgta 1552201 gaaaaagaca gccttgatat ggataaagtg tacctgaaat cccgttatga taaaggtgaa 1552261 gcagcatatt tgaactgccc gatgacagaa gaagagtttg accgttttca tgaagcatta 1552321 acatcagcag aaacagtgcc gttaaaagaa tttgaaaaag agattttctt tgaaggctgc 1552381 atgccgattg aagtcatggc aaaacggggt aagaaaacaa tgcttttcgg tccgatgaaa 1552441 ccagttggtc tagagcatcc tgttacagga aaacgccctt atgccgtcgt tcagctcaga 1552501 caggatgatg ctgcgggaac actttataat attgtaggat tccagacaca tttaaaatgg 1552561 ggagaccaaa aggaagttct caagttgatt ccaggacttg aaaatgtaga aatcgtcaga 1552621 tatggcgtga tgcatagaaa cacatttatt aactctccaa gcctgttaaa gccgacttat 1552681 caatttaaaa accgcagtga tctgttcttt gcaggccaaa tgacgggagt agaaggatat 1552741 gtggaatcag ctgcctcagg acttgtagca ggcattaatg cggcgaagct tgtattggga 1552801 gaagagcttg tgatcttccc tcaggaaaca gcaattggca gtatggcaca ttatattaca 1552861 acaacaaacc agaagaactt ccagccgatg aatgcaaact ttgggctttt gaaagaattg 1552921 ccagttaaaa ttaaaaataa aaaagaacga aatgaacaat acgcgaaccg tgcgattgaa 1552981 acaattcaaa caatttcgaa aacaatatag gtattgattg caacctgagc gcgatttgtg 1553041 ataccattta aaagcccttc ctggggaggt attaggcatg gagaatgtta agaatttcgt 1553101 aaagttattc gttgaatatt tacaaattga aaaaaattat tcacaatata ctattgtgaa 1553161 ttatgtggat tcaattgaag aattcgagac tttcctgcgc gttcaaggta taaatggatt 1553221 tgaagaagct gcatatcaag atactaggat ttttttgaca gaagcctatg aaaaaggttt 1553281 atcgagaaga acaataagca aaaagatatc tgcattaaga agcttttata agtttctgat 1553341 gcgggaaaag cttattgaag aaaatccgtt tcagcttgtt catctgccaa aacaggagaa 1553401 acggataccg aagtttctat atcaaaaaga gcttgaggag ctgtttgaag tttcagatat 1553461 aagccagccg gccggaatga gggatcaagc gctgttagag ctgctctatg ccactggaat 1553521 gagggtcagt gaatgctgtt ccataactat taacgacgtt gatttattta tggacactgt 1553581 gcttgttcac ggtaaaggca agaagcagcg ctatatcccc tttgggtctt atgcccgcga 1553641 agcgttgaag gtatacatga atagcggaag acagtgcttg ctgatgaagg caaaagaacc 1553701 tcatgatcta ttattcgtaa atcaaagagg cggaccgctt acagcccgtg gcatcagaca 1553761 tattttaagc gggcttgttc aaaaagcgtc aagcacttta catatccatc cgcatatgct 1553821 tcgacatacg ttcgccacgc atctgttaaa tgaaggagcg gatttgagaa gcgttcaaga 1553881 actgctcggg cattccaatc tgtcttctac acagatatac acgcacgttt cgaaggaaat 1553941 gttgagaaac acatatatgt ctcaccatcc aagagcattt aagaaaaatt aaaggaggcc 1554001 ctttatgtca tcttttcatg cgaccacaat atttgccgta cagcataaag gacgaagcgc 1554061 tatgtccgga gacggccaag taacatttgg tcaggctgtt gtcatgaaac acacggcacg 1554121 gaaagtgaga aaactgttta acggcaaagt tcttgctggt tttgcgggat ctgttgcaga 1554181 cgctttcact ttattcgaaa agtttgaagc taagcttgaa gaatataacg gcaacttaaa 1554241 acgggcggct gttgagcttg caaaggaatg gcgcagtgat aaagtgctaa gaaagctcga 1554301 agccatgctg attgttatga atcaggatac tttgcttctc gtatcgggaa caggcgaggt 1554361 gatcgaacca gatgacggca ttctcgcgat tggatcagga ggcaattacg ctttggcagc 1554421 gggaagagca ctgaaaaagc atgccgggga aagcatgtct gcaagtgaga ttgccagagc 1554481 cgcgttagaa acagcaggcg aaatttgtgt ttacacgaac gatcaaatca tactggaaga 1554541 gcttgaatag aaaggacttg aggcgcatgg aaaaaaaacc gttaactcct agacagattg 1554601 tagatcggtt agaccaatat attgtcggtc agcaaaatgc gaaaaaagct gtcgccgtgg 1554661 cattaagaaa ccgctataga agaagtcttc tggatgaaaa gctgaaggac gaggtcgttc 1554721 cgaaaaacat tttaatgatg ggtcctaccg gcgtcgggaa aactgaaatt gccagacgaa 1554781 tcgctaagct ttcaggtgcg ccatttatca aaattgaagc tactaaattt accgaagtcg 1554841 gctatgtagg cagagatgtt gaatcaatgg tcagagatct tgtggagact tctgttcggc 1554901 ttataaaaga agagaaaatg aatgaagtaa aggaacaggc agaagaaaat gcaaacaaac 1554961 gcattgttcg tctgttagtt cctgggaaga aaaaacaatc tggtgttaaa aatccgtttg 1555021 aaatgttttt tggaggcagc cagccgaatg gtgaagatga ggcggagagc caggaagaag 1555081 caaacatcga agaaaaaaga aaacgaatgg cgcatcagct ggctttagga gagctcgaag 1555141 actactatgt aacagtagaa gtcgaagaac agcagccttc tatgtttgac atgctgcagg 1555201 gctcgggtat ggagcagatg ggtatgaaca tgcaggatgc gctgagcgga ttaatgccaa 1555261 agaaaaagaa gcggcgcaaa atgacagtca gagaagccag aaaagtcctg acgaatgaag 1555321 aagcaagcaa actcatcgat atggatgaag tcggccagga agctgttcag agagcagaag 1555381 agagcgggat tatctttatc gatgagattg ataaaatcgc aaagaacggc ggtgcatctt 1555441 cttctgccga tgtttcaaga gaaggtgttc agcgggatat ccttccgatt gttgaaggtt 1555501 ctaccgttgt cacaaaatat ggttctgtaa aaacagacca tgtattattt attgcagcag 1555561 gagcgtttca tatggccaaa ccgtctgatt tgattcctga gctgcagggg cgtttcccga 1555621 ttcgtgtaga actgaacaaa ctcacggtag acgacttcgt gagaattttg gttgagccgg 1555681 ataatgcgct gctgaaacaa tatcaggcat tattgcagac agaaggtata tctcttgaat 1555741 tttctgacga agctattcat aagattgctg aagttgctta tcatgtgaac caggacacag 1555801 ataatatcgg tgcgagacgc cttcatacaa tacttgaacg cctattagaa gatttgtcgt 1555861 ttgaagctcc agatgtaacg atggagaaaa taacgattac accacagtat gtcgaagaaa 1555921 agctcggaac gatagccaaa aacaaagatt taagtcaatt tatattgtga aaaatttaat 1555981 atgaggaatg tttaggagga ttatttatca tggctttatt acaaaaaaca agaattatta 1556041 actccatgct gcaagctgcg gcagggaaac cggtaaactt caaggaaatg gcggagacgc 1556101 tgcgggatgt aattgattcc aatattttcg ttgtaagccg cagagggaaa ctccttgggt 1556161 attcaattaa ccagcaaatt gaaaatgatc gtatgaaaaa aatgcttgag gatcgtcaat 1556221 tccctgaaga atatacgaaa aatctgttta atgtccctga aacatcttct aacttggata 1556281 ttaatagtga atatactgct ttccctgttg agaacagaga cctgtttcaa gctggtttaa 1556341 caacaattgt gccgatcatc ggaggcgggg aaagattagg aacacttatt ctttcgcgtt 1556401 tacaagatca attcaatgac gatgacttaa ttctagctga atacggcgca acagttgtcg 1556461 gaatggaaat cctaagagaa aaagcagaag aaattgaaga ggaagcaaga agcaaagctg 1556521 tcgtacaaat ggctatcagc tcgctttctt acagtgagct tgaagcaatt gagcacattt 1556581 ttgaggagct tgacggaaat gaaggtcttc ttgttgcaag taaaattgct gaccgtgtcg 1556641 gcattacccg ttctgttatt gtgaacgcac tcagaaagct ggagagcgcc ggtgttatcg 1556701 agtctagatc attaggaatg aaaggtactt atatcaaggt actaaacaac aaattcctaa 1556761 ttgaattaga aaatctaaaa tctcattaat cacaaaaaga accctttttg agggttcttt 1556821 ttttatttca aataaaggaa atcaataagc tttatttcct gggttgaaag tctttctatg 1556881 taataatttt aataaatttt gcatttttct tcaaaaagtt tcaaaaatgc cgaaaagaaa 1556941 ggagaaaaaa cagaaattct gctattttca ggcttatatc aaggcgagaa atgtagttct 1557001 aacaatctag gactttatac ctagttgcaa aatagataat tgtgaggaca tttttttaca 1557061 cgaacttcat agactttatg cctgttattt cttacaataa gcatatagtt ttacaattct 1557121 cgacaaggat attgagggtg aaaaaaactg aaatggaggt aagtggattt gagcttattt 1557181 tctggaacga tacaaaatct tgaaaatgcc ttgagcagag cggatattaa gcaaaaagtc 1557241 ataactaata atatcgccaa tatagataca ccgaactata aggcaaaaaa agtctctttc 1557301 caaaatttat tagatcaaga atcctcgcgt cttgaagcga taaaaacaga ctatcgtcat 1557361 gttgattttt ctgatactga ttcgaattat tcaattgttg cgagcggaga tacatcgtat 1557421 cagcaaaacg gaaacaatgt tgatgttgac aaagagatga cagaattggc gcaaaatcaa 1557481 atcaactatc aagctttggt tgaaagaatg aacggtaaat ttaattcgct gaagaccgta 1557541 ttaacaggag gaaaatgatg acagcttttc atagcttaaa tgtttcagca tcggctttaa 1557601 cagctcagcg agtcagaatg gacgttgtat catctaactt agcaaatatg gatacgacaa 1557661 gagctaagca ggtgaatgga gagtgggtgc cttacagaag aaaaatggtt tcccttcagt 1557721 caaaaggtga atcgttctct tccattctca attctcaaat gagcggaagc gggaatgctg 1557781 gaaacggtgt gaaggtttca aaaattacgg aggatgattc ggattttaat cttgtctatg 1557841 atccgacaga ccctgatgca aacgctgaag gatatgtaca aaagcctaat gttgatccat 1557901 taaaggaaat ggttgatctt gtcagcagca ctagatcata cgaggcgaat gtcacggcga 1557961 tgaatgccac aaagggaatg ctgatgaagg cgttagaaat cggaaagtag gcgaactgtt 1558021 aaacaaggtg aaaaaacgat ttaattaagg tattaggggg ataacaatgc aatccttgaa 1558081 ttatgaagat caggtgcttt ggacgcgctg gaaagagtgg aaagatccta aagccggtga 1558141 cgacttaatg cgccgttaca tgccgcttgt cacatatcat gtaggcagaa tttctgtcgg 1558201 actgccgaaa tcagtgcata aagacgatct tatgagcctt ggtatgcttg gtttatatga 1558261 tgcccttgaa aaatttgacc ccagccggga cttaaaattt gatacctacg cctcgtttag 1558321 aattcgcggc gcaatcatag acgggcttcg taaagaagat tggctgccca gaacctcgcg 1558381 cgaaaaaaca aaaaaggttg aagcagcaat tgaaaagctt gaacagcggt atcttcggaa 1558441 tgtatcgccc gcggaaattg cagaggaact cggaatgacg gtacaggatg tcgtgtcaac 1558501 aatgaatgaa ggtttttttg caaatctgct gtcaattgat gaaaagctcc atgatcaaga 1558561 tgacggggaa aacattcaag tcatgatcag agatgacaaa aatgttccgc ctgaagaaaa 1558621 gattatgaag gatgaactga ttgcacagct tgcggaaaaa attcacgaac tctctgaaaa 1558681 agaacagctg gttgtcagtt tgttctacaa agaggagttg acactgacag aaatcggaca 1558741 agtattaaat ctttctacgt cccgcatatc tcagatccat tcaaaggcat tatttaaatt 1558801 aaagaatctg ctggaaaaag tgatacaata atgaatttca tggttagcga gtgaaaaaca 1558861 tgtcaacact attatggctt ttaagcttta tgctccacgg cgttcttctg tacgctgtca 1558921 ttatcctgta tacgaggctc gctgcagtga aagaaacaga aaaacagcaa aaacagatac 1558981 ttgaagagac ggaaaacacc ttggcggcat ttctgcttga attaaaagaa gaaaatgaga 1559041 aactgataga aaataaagct tcatctgcaa gtcaatcaga tgaagaatcc caaaagtcag 1559101 gccttcagac ctctgaaaca tatcaagagc gggatccagt ccaagaggca gagaatcttc 1559161 ctgaacatat tgaaggtctg attacagagg ttgaccgtcg ggaagagctc gtaaacagtg 1559221 aggtccaatc atttgaagac caggtcatag aattatatga acagggatat tcggcaagtc 1559281 aaattgccca gaaaatgaag agcggaaaga cagaaatcga gctattttta aaatttcgct 1559341 ccaaaggtgt aaaggattct tgattgtcgg ataaagctgt gttatattat gtcttggtgt 1559401 taaatacaca cgcttaacga tttatgcaga gggtgctgca ggcggcagtt ctgtacaaaa 1559461 atgacctaag cggaggaaaa aaaccattat attaggagga aataacatgt cagtcatttc 1559521 tatgaagcaa ttgcttgaag ctggtgttca cttcggtcac caaacacgcc gttggaaccc 1559581 aaaaatgaag cgttacattt tcacggagcg taacggaatc tacatcattg accttcaaaa 1559641 aacagtcaaa aaagtagagg aagcttacaa cttcactaaa aatcttgctg ctgaaggcgg 1559701 aaaaatcctt ttcgtcggaa caaaaaaaca agctcaagat tctgttaaag aagaagctca 1559761 acgctctggc atgtactatg tcaaccaacg ctggttgggc ggtacattaa caaacttcga 1559821 aacaatccaa aaacgtatta aacgtcttaa agacattgaa aaaatgcaag aaaacggtac 1559881 gtttgatgta cttcctaaaa aagaagtcgt tcaattgaaa aaagaattag agcgtcttga 1559941 aaaattccta ggcggaatta aagatatgaa ggatcttcct gatgcattat tcatcatcga 1560001 tcctcgcaaa gagcgcatcg ctgttgcgga agctcgcaaa ttaaacatcc ctatcatcgg 1560061 tatcgtagat actaactgtg atccagatga aatcgatgtt gttatcccag cgaacgatga 1560121 cgctatccgc gctgttaaac ttctaacttc taaaatggca gatgcaatct tagaagcgaa 1560181 gcaaggcgaa gaagaagcgg aagttgctga agaaactgca ccagaaacag aaacaacaac 1560241 tgcgtaacct attcaaaagg tgataagagg gactgccttt tatcaccttt tttcaagaaa 1560301 aatgtgtaat atacatactc ttgtttaaac atataaggag gaatacaaat ggcaattact 1560361 gcacagcaag taaaagaact gcgtgaaaaa actggcgcgg gcatgatgga ttgtaaaaaa 1560421 gcgttaactg aaactgacgg agatatggac aaagcaattg accttttaag agaaaaagga 1560481 attgcaaaag cagcgaaaaa agctgaccgt atcgcagcag aaggttctac tcttattaaa 1560541 actgacggca acaaaggcgt tatcctagaa gtaaactctg aaactgattt cgttgcgaaa 1560601 aacgaaggtt ttaaagagct tcttaacact ttagctgacc accttcttgc aaacacgcca 1560661 gctgatgttg aagaagcaat gggccaaaaa atggaaaatg gctcaactgt tgaagagtac 1560721 atcacaagcg cagttgctaa aatcggtgag aaaatcactc ttcgccgctt tacagttctt 1560781 acaaaagacg acagctctgc attcggtgcg taccttcaca tgggcggccg catcggtgta 1560841 ttaactgttc tcaacggtac aactgatgaa gaaactgcga aagatatcgc aatgcacgtt 1560901 gctgcagtta accctcgtta catttctcgt gatcaagtat ctgaagaaga aacaaatcat 1560961 gagcgtcaaa tcttaactca gcaagccctc caagaaggca aacctgaaaa catcgtagcg 1561021 aaaatggttg aaggccgtct gaacaaattc ttcgaagaaa tttgtctatt agaccaagcg 1561081 ttcgttaaaa acccagatga aaaagtgaaa caagttattg cagcgaaaaa cgctactgtt 1561141 caaacttttg tccgctatga agttggagaa ggcatcgaaa aacgtcaaga aaactttgct 1561201 gaagaagtaa tgaaccaagt gaaaaaataa tggtgaaaag atttcgcggc taagtcgcgt 1561261 cttttcaggc agtatagggg acacattttg tgttccctat ttttaaaact atatttacaa 1561321 accttttttt ctcttgcata atagaaaacg gcaatgttta cacttggagg ttatcatgga 1561381 aaaaccaaaa tacaaacgta tcgtattaaa gcttagcggg gaagcattgg caggagaaca 1561441 gggaaatgga attaacccga ctgtcattca atccattgca aagcaagtga aggaaatcgc 1561501 tgagcttgaa gtcgaagtgg ctgttgttgt aggcggcggc aacttatggc gcggaaaaac 1561561 aggaagtgac ctgggcatgg accgcgcgac tgctgactat atgggaatgc tggcgacagt 1561621 aatgaattcg cttgctcttc aagacagctt ggaaacactc ggaatccagt ccagagtgca 1561681 aacatccatt gaaatgagac aagttgctga accgtacata agaagaaaag cgatacgcca 1561741 cttagagaaa aaacgtgtcg ttattttcgc tgcgggcaca ggaaacccat atttctcaac 1561801 tgatacgaca gctgcactgc gggctgctga aattgaggca gacgttattt taatggctaa 1561861 aaataacgtt gacggtgtgt ataatgctga tcctagaaaa gatgaatcag ctgttaagta 1561921 tgaatcactt tcttatcttg acgttcttaa agacggcctg gaagtcatgg attcaacagc 1561981 ttcctcttta tgcatggaca atgacattcc gcttatcgtc ttttctatta tggaagaagg 1562041 aaatatcaaa cgtgccgtta tcggtgaatc aatcggaacg atcgtgaggg ggaaataacg 1562101 tgtcaaaaga agtattaact caaacaaaag aaaaaatgga aaaagcaatt gctgcttatc 1562161 agcgcgaatt ggctactgta cgcgcaggcc gtgcaaatcc atcattatta gataaagtaa 1562221 cggttgaata ttacggagcg cagacacctt taaatcagtt gtcttctatt aacgtgcctg 1562281 aagctcgtat gctcgttatc acgccatacg ataaaacagc aatcggtgat atcgaaaaag 1562341 cgattttaaa agctgattta ggtcttacac caacaagtga cggcaatatg attcgaattg 1562401 caattccggc actaacagaa gagagacgga aagaattagt gaaagttgta aaaaaatatg 1562461 ctgaagaagc aaaagtagct gttcgtaacg ttcgccgtga tgctaacgat gatctcaaaa 1562521 aacttgagaa aaacggagac attactgagg atgaactgcg tgcttccact gaagacgttc 1562581 aaaaactgac agatgaatat gtgtcaaaaa ttgacagtgt cacaaaagac aaagaaaaag 1562641 aaatcatgga agtttaatga aaaactatgt acaatagata atagtgaaaa gaccctctca 1562701 tgtttacagg gggttttttt gttaatactg ttgattacat tgattatcag cagggaatgt 1562761 aacctttttg ggtgacggag gaatctcatg ctcaacatac tcaaaaattg gaagaatcag 1562821 caaactgcgg cttccaactt agaacgttat acaaaagaag acatacttaa gggagaaatt 1562881 cccgaacaca tcgccattat catggatgga aatggccgtt gggctaaaaa acgctctctt 1562941 cccagaattg caggccacca tgaagggatg aaggtggtaa aaaggaccac gaagctcgca 1563001 aacgaattag gtgtcaaagt actgacattg tatgcatttt caacagaaaa ctggaaaaga 1563061 ccgaaaatgg aggtcgattt tttaatgaag cttccggaag aatttttgaa tacgtatctt 1563121 ccagagcttg ttgaggaaaa tgtacaggtt cggatcattg gggatgaaac ggctttgccg 1563181 gcgcacacat tacgtgcgat tgaaaaagct gtacaggaca cggcgcaaaa cgacggaatg 1563241 atccttaatt ttgctcttaa ctatggaggc cgtactgaaa ttgtcagtgc tgcaaaatca 1563301 ctcgcggaaa aagtgaagga aggctctttg aatattgaag acattgatga atcgcttttt 1563361 tctacttatt tgatgactga atctttgcag gatcctgaac ttttaattcg aacgagcggc 1563421 gagataaggc tgagtaattt tatgctatgg caggttgcct acagtgaatt tgtctttact 1563481 gacgtcttgt ggcctgactt taaagaagat cacttcttgc aggcgttagg agagtttcag 1563541 cagagaggcc ggaggtttgg cggaatttag aggatggtgg acatgaaaca aagaattttg 1563601 acaggtgttc tggcagcaat tgtattttta tttttggtta ttgtcgggaa attgccgttc 1563661 accatattaa tttatgctat gggcagtgtg gcgctttttg aacttttacg gatgaaaaag 1563721 ctgaagctgg tttcactgcc gggtttgatc ggtcttttat tattgtggat gttcttatta 1563781 ccaagccagt attcgttttt tgaagcggac gggatttcca aaatggaaat cgctttattt 1563841 gcggtactgc tattgctgac ttacacagtg ttggtcaaga acacctttac ttttgatgaa 1563901 gtcgggttta ttacgcttgc agcaatttac atcggaatgt gttttcatta ttttatcgaa 1563961 atcagaaatc ttgaccaata cggattaaca tacatttttt atgcgtgtgt tgtcatttgg 1564021 tccaccgatt ccggtgccta ttttgtcggt aaatcgcttg ggaagcggaa actgtggcct 1564081 gaaatcagtc cgaataaaac agtggaaggg tttgcaggcg gaattgtcat cgcacttgta 1564141 ttggcgacga tttttcagct tgttgcacaa cttccgatcc cgtatatcta tctgctgttg 1564201 atcacgctgt ttttgtctgt ttttggacaa ctgggagatt tagtggaatc cgccttgaaa 1564261 agacattacg atgtaaagga ttctgggaat attcttcccg ggcatggcgg tatattagac 1564321 cgttttgaca gtttcttgtt tgtcatgcct ttcttgtact ttctgcttgc ccttttttca 1564381 taaaaaagtc taatatgaat atgagactga tcatgcagca ataagaatag gagtagtggc 1564441 aactttgaaa aatatttgtc ttttaggagc aacaggatca atcggcgaac agactcttga 1564501 tgtactgcgt gcacatcaag accaatttca gctggtatct atgtcgtttg gcagaaatat 1564561 tgataaggcc gttccaatga ttgaggtctt tcagccgaag tttgtctctg tcggtgatct 1564621 ggatacatat cataaattaa aacaaatgtc tttttctttt gaatgccaaa tcgggctggg 1564681 agaagaagga ctgatagaag cagcagtgat ggaggaggtt gacattgttg tcaacgcttt 1564741 gcttggaagc gtcggtctta tcccgacatt aaaggcaatt gaacagaaaa aaacaattgc 1564801 gcttgcaaat aaggaaactc ttgtcactgc agggcatata gtaaaagaac atgctaagaa 1564861 atatgatgtt ccgctgctgc ctgttgacag tgagcattca gccatttttc aagctcttca 1564921 aggcgaacag gctaaaaaca ttgaacgcct catcattacg gcatccggcg gaagttttcg 1564981 ggacaagacg cgggaggagc tcgaatcagt aacggttgaa gatgcattaa aacatccaaa 1565041 ctggtcaatg ggtgcaaaaa ttacaattga ttcggctaca atgatgaata agggattaga 1565101 ggtgatcgag gcacactggc ttttcgatat accttatgaa caaattgatg tggttttaca 1565161 taaggagagc atcatccatt caatggttga gttccatgat aaaagtgtga tcgcacagct 1565221 cggaactccg gatatgagag tccccattca atatgcgctc acttatcctg accgattgcc 1565281 attaccagat gcgaaaaggc ttgaattatg ggaaatcggc agccttcatt ttgagaaagc 1565341 tgattttgac aggttccgat gcttacaatt tgcttttgaa tcaggtaaaa taggaggaac 1565401 aatgccgaca gtgctaaatg cggcaaacga agtagctgtc gctgcctttt tagctggcaa 1565461 gataccgttt ttggctattg aagactgtat cgaaaaggca ctaacccgcc atcaattact 1565521 gaaaaaaccg agcctggcgg acattcaaga agtggacaaa gatacccggg gatacgtcaa 1565581 ttcaatactc acataaggtg gtatgttcgt gaatacagtt atagcgttta tcattatttt 1565641 cggaacgctc gttttcttcc atgaactggg ccatttattg ctagcccaaa gagcgggaat 1565701 tctctgccgt gaatttgcga tcggcttcgg tccaaagatt ttttctttca aaaaaaatga 1565761 aacagtttat acgatcaggc tgcttccggt cggcggattt gttcgtatgg ccggcgaaga 1565821 tccggaaatg attgaggtga aacccggata cacggtcggg cttctgttta ataaggaaga 1565881 tcaagttgag aaagtcatca tcaatcaaaa ggaaaaatat ccggatgctt tagtcattga 1565941 agtggaaaca gcggatctag agcatgacat gaagatcacc ggttatgaac aggggaaaga 1566001 ggacgaactt tccagcttta ctgtcagcga aacatccttt tttattgtag acggagaaga 1566061 agtgcagatt gcgccgtata atcgccaatt tggttccaaa cctgtatggc agcggattaa 1566121 agcaattgct gcagggccga ttatgaactt tattttagct tacgtcattt tagtgatgct 1566181 tgggctgatt caaggcgtac cgtcaaatga acctatgctc gggcagctga cagacaatgg 1566241 acgggcggct gaagcagggc taaaagaagg ggattatatc caaagcatta acggagagaa 1566301 aatgaggtct tggactgaca ttgtctccgc tgtaaaagaa aacccggaga aagaaatgga 1566361 cgttgcagta aaaagagata acaaaacgct tcatatttcg gtgactccgg aagctgttaa 1566421 agatgagaac aaaaaaacaa tcggacgttt cggttcctat gcgccgactg aaaaaggcgt 1566481 actctcagcg gttgcttacg gcgcgacatc aacagttgat gtcaccaaag ccattttaac 1566541 caatctgagc aaattagtaa caggccaatt taaactcgat atgctgtcag gtcctgtcgg 1566601 catatatgac atgacagacc aagtggcgaa aacagggatc gtgaacttat ttcagtttgc 1566661 ggcgttttta agcattaacc ttgggattgt caacctgctt ccgattccgg cacttgacgg 1566721 aggaagactg ttgtttctat ttattgaagc gattcggggc aaaccgatta acagggaaaa 1566781 agaagcattt gttgtgttta tcggagtagc tttcttaatg cttcttatgc tggttgtcac 1566841 atggaacgat atccagcggc tgtttttgta aacgaaaagt aaatcaatca gaggtgcgaa 1566901 gaaatgagac aaagcttgac gcttattcct acgctccgtg aagttccagc tgatgccgaa 1566961 gcaaaaagtc atcagcttct tctgagagca ggatttatca gacagaatac gagcggggta 1567021 tacagctata tgcctcttgc gtataaggtg attcaaaaca ttcagcagat tgttcgagag 1567081 gaaatggaga aaattgatgc cgtagaaatg ctcatgcccg cattgcagca ggcagagaca 1567141 tggcaggaat caggcagatg gtatacgtat ggtcccgaac tgatgagact aaaagaccgt 1567201 catggccgtg aatttgcttt aggggcaacg catgaagagg ttatcacttc gcttgttcgc 1567261 gatgaggtta aatcttataa gcgtctccct ctgactcttt atcaaattca gtctaagttc 1567321 agagatgaaa aacgtcctcg cttcggtttg ttaagaggcc gcgaatttat tatgaaggat 1567381 gcgtactctt tccatgcatc tgcagagagc ctggatgaaa cgtatcaaaa aatgtacgag 1567441 gcctattcta atatttttgc ccgctgcggc attaatgtaa gacctgttat cgctgattca 1567501 ggcgcaatgg gaggaaagga tacgcacgaa tttatggcac tttctgcgat cggagaggat 1567561 acgattgcgt attctgatga atcacagtac gcggctaata tcgagatggc tgaagttctt 1567621 caccaggaag ttccttcaga tgaagagcct aaagctctag agaaggttca tacgcctaac 1567681 gtgaaaacaa tcgaagaact gactgcgttc ttacaggttt cggctgaagc gtgcattaag 1567741 tcagtattgt ttaaagctga tgaccgtttt gtcttagtgc ttgtaagagg ggatcatgaa 1567801 gttaacgata ttaaagtgaa aaacttgctt catgcagaag ttgtagagct tgctacacat 1567861 gaagaggtca ttcagcagct cggaacagag ccaggctttg taggccctgt cggtattcat 1567921 caggatgtgg aagtatatgc cgatcaagct gtgaaagcaa tggttaatgc tgttgccggg 1567981 gcaaatgaag gagatcatca ttataaaaat gtcaatgtga atcgtgacgc gcaaattaaa 1568041 gaatttgctg atcttcgttt tattaaagaa ggtgatcctt caccagacgg caagggaacg 1568101 atccgttttg ctgagggaat cgaagtcgga caagtcttta agctcggaac acgctattca 1568161 gaagcgatga atgcgacata tttagatgaa aacggacgcg cgcagccaat gctgatgggc 1568221 tgttacggaa tcggtgtgtc aagaacgctt tctgctattg ctgaacagca tcacgacgaa 1568281 aaaggcttaa tatggccaaa aagcgttgcg ccgtacgatc ttcatattct tgctttgaac 1568341 atgaaaaacg atgggcaaag agagcttgct gaaaagctgt atgccgattt aaaagcggaa 1568401 ggctatgaag tgctctatga tgaccgtgct gagcgtgccg gcgtaaaatt cgctgattca 1568461 gatttaatcg gccttccaat ccgcatcact gtcggaaaac gagctgacga aggaatcgtc 1568521 gaagtgaaaa ttcgtcaaac tggtgagtca actgagattt cagtagacga attatctgcg 1568581 tttatcagca agcagtaatc accataacga tttatcaaaa aacatgttaa aatagaaata 1568641 atagaaggta cctcattgcc tgaggtacct tcacttatga tgtttttagg gagggatact 1568701 gtcttaatgg aacagttatc agtaaacaga aggcagtttc aaattcttct gcagcagatt 1568761 aatatgacag atgatacctt catgacatac tttgaacatg gcgagattaa aaagctgaca 1568821 attcacaaag cttctaagtc ttggcatttt cattttcaat ttaaatcttt gctgcctttt 1568881 caaatatatg acacattaac aacgaggctg acgcaatcgt ttgcccacat agcaaaagtg 1568941 acatcttcaa ttgaagttca ggatgccgag gtcagtgaaa gtatcgttca agactactgg 1569001 tcacgctgca ttgaagaact gcagggcatt tcgccgccga ttatcagtct tttaaaccag 1569061 caaaaaccga agctgaaggg caataaactg attgtcaaaa ccaaaacaga tacagaagcg 1569121 gctgcgctaa agaacaaata cagttccatg attcaagcag aataccgtca atttggcttt 1569181 ccggatcttc agcttgatgc tgaaatattt gtatccgagc aagaagttca aaagtttcgg 1569241 gagcaaaagc ttgcggaaga ccaagagcgg gctatgcagg ccttgattga aatggagaag 1569301 aaagataaag aaagtgatga agaccaagca ccatctggtc ctcttgttat cggttatcaa 1569361 attaaagata acgaggaaat ccgaacactt gacagcatca tggacgaaga acggagaatt 1569421 acggtccaag gttatgtgtt tgatgtggag acgcgcgagc tgaagagcgg gcgcacgctg 1569481 tgtatcttca aaattacaga ctatacaaat agtattttga tcaaaatgtt tgcacgtgaa 1569541 aaagaagatg cggcgctgat gaagtctctg aaaaaaggaa tgtgggtaaa agcacgcgga 1569601 agcattcaaa atgatacatt tgtcagagac cttgtcatga tcgcaaatga cgtaaacgaa 1569661 ataaaagcaa aaacccgtga agattcagca cctgaaggag aaaaaagagt ggaattgcat 1569721 cttcattccc caatgagcca aatggatgct gttacgggta tcggaaagct tgtcgaacag 1569781 gcgaaaaaat gggggcatga ggccatcgct ttgaccgacc atgctgtcgt tcaatccttc 1569841 cctgatgcgt attctgcggc caaaaagcat ggaattaaaa tgatttacgg gatggaagcg 1569901 aatctcgtgg atgatggcgt gccaattgct tataatgccg cacatcgtct gctcgaagaa 1569961 gaaacatatg ttgtttttga cgttgagacg acaggattgt ctgctgtata cgataccatt 1570021 attgagctgg ctgcagtaaa agtaaaaggc ggagaaatta ttgataaatt tgaggcgttt 1570081 gcgaacccgc atcgtccgct ttccgccaca atcatagagc tgacagggat cacagatgat 1570141 atgctacaag acgctccgga tgtcgtagat gtaataagag atttcagaga atggattggc 1570201 gatgatattc ttgtcgctca taatgcaagc tttgatatgg gattcttaaa tgtagcctat 1570261 aaaaaacttc ttgaagtcga aaaagctaaa aacccagtca ttgatacgct tgaacttgga 1570321 cgttttctct atccggaatt taagaaccac cggttgaaca cactttgtaa aaagtttgat 1570381 atcgagctca cacagcatca ccgtgcgatc tatgatactg aggcaaccgc ttatttgctt 1570441 ctgaaaatgc tgaaagacgc agctgaaaaa ggtattcagt accatgatga gttgaatgaa 1570501 aatatgggtc agtccaatgc ttatcaaaga tcaagaccgt atcatgcaac attacttgcc 1570561 gtgaacagca cgggacttaa aaatttattt aagcttgtgt cactttctca tattcattat 1570621 ttttacagag tgccgcgtat tccgagatct cagcttgaga aatacaggga agggcttctg 1570681 atcggttctg cttgtgacag gggagaggtt tttgagggaa tgatgcaaaa atcgcctgaa 1570741 gaggtggaag atatcgcgtc attctatgat taccttgagg ttcagccgcc tgaagtgtat 1570801 cgtcacttgc tggagcttga actggtccgt gatgaaaaag cgctgaaaga aattattgcg 1570861 aatatcacga agctggggga aaagcttaat aaaccggttg ttgctacggg aaatgttcat 1570921 tacttgaatg atgaggataa aatctacaga aagattttaa tatcctcaca aggcggggca 1570981 aatccgctga ataggcatga actgccgaaa gtgcatttca gaacgacaga cgaaatgctt 1571041 gaagcttttt ctttcttagg tgaagaaaaa gcgaaggaga tcgtagtcac caatacccaa 1571101 aaggttgctt ctttagttga tgacatcaag ccgattaaag atgatttata tacgccgaaa 1571161 atcgaaggcg ctgatgaaga gatcagagaa atgagctatc agcgtgcaag aagcatttac 1571221 ggggaagagc tgcctgaaat tgtcgaagcg cggattgaaa aagagttaaa gagtattatt 1571281 ggccacggat ttgctgttat ttacttgatc tctcacaaac ttgtaaaacg ttcactagat 1571341 gacgggtatc tcgttggttc ccgtggttcc gtaggatctt cattagttgc gacacttact 1571401 gagattactg aggtaaaccc gctgccgccg cactatgttt gtcctgagtg ccagcattct 1571461 gagttcttta atgacggttc tgtcggttct ggttttgacc tgcctgacaa gacatgccct 1571521 cattgcggaa cgcctttgaa aaaagacggc catgatattc catttgaaac gttcttagga 1571581 tttaaagggg acaaagtacc tgatatcgat ttgaacttct caggggaata tcagccgcaa 1571641 gcacacaatt acacaaaagt attgttcgga gaagacaatg tatatcgtgc gggaacaata 1571701 ggcacggtgg cagaaaaaac agcctacggt tatgtaaaag gctatgccgg agacaacaat 1571761 cttcatatgc gcggtgccga aatagatcgg ctcgtacagg gatgcacagg tgtaaaacgt 1571821 acaactggac agcaccctgg cggtattatc gtagttccgg attatatgga tatttatgat 1571881 ttttcaccga tccagttccc ggcagatgcc acaggttcag agtggaaaac gactcatttt 1571941 gatttccact ccatccatga caacctgtta aaacttgata ttctcggaca cgatgacccg 1572001 actgttattc ggatgcttca agacttaagc ggaatagatc cgaaaacaat tccgacggat 1572061 gatcctgaag tgatgaagat cttccaggga accgaatcac tcggtgtgac tgaagaacag 1572121 attggctgta aaacgggcac tcttggaatt cctgaattcg gaacccgatt tgtccggcag 1572181 atgcttgaag atacaaagcc gaccactttt tctgagctcg ttcagatttc aggcttgtct 1572241 cacggaactg atgtatggct tggcaatgca caggagctca tccacaataa tatttgtgag 1572301 ctgagtgagg ttatcggctg ccgtgatgac attatggttt atttaatcta tcaaggcctt 1572361 gagccgtccc ttgcctttaa aatcatggaa ttcgtgcgta aaggaaaagg attaacgcct 1572421 gaatgggaag aagaaatgaa aaataacaat gtcccagact ggtatattga ttcctgtaaa 1572481 aagattaaat acatgttccc gaaagcccac gccgcggcat atgtcttaat ggcagtccgc 1572541 attgcttact ttaaagtgca tcatgctctt ttgtattatg cggcttattt taccgttcgt 1572601 gcagatgact ttgatattga tacaatgatc aagggctcta cagcaatcag agcggtaatg 1572661 gaggatataa acgctaaagg acttgatgct tcaccgaagg aaaagaacct tctgactgtt 1572721 ttagaattag cgcttgagat gtgtgagaga ggctattcat tccaaaaagt cgatttatat 1572781 cgctccagcg ccacagagtt tattattgac ggcaacagtc ttattccgcc gtttaactct 1572841 attccagggt tagggacgaa cgctgctttg aacattgtaa aagctcgcga agaaggcgaa 1572901 ttcctctcaa aagaagattt gcaaaagaga gggaaagtat caaaaacgat tttagagtac 1572961 ttagatcgcc atggctgtct ggagtcactg cctgatcaaa accaattgtc actgttctaa 1573021 tatggaaagc agaatttctc agaaattctg cttctatgca tacataagcg caaaaagtgc 1573081 catcgtaata ttagagtttc tgtcacttgc ttaggtatga aggtaagcgt atatccattt 1573141 gcaataaaaa tatggttatg gtatagtttt attggaaatg ctaacgatta ccgaggcaaa 1573201 gagtggggaa acccgctctt ttgtattgaa caggagaatt ttgtctcgac atgttcatcg 1573261 tttacttttt agcccctgct cttttgaagc agggttttta tgcagagtga cgagacgaat 1573321 atgagatcga cagcacaagg aggaagaaca tgagcaaaaa agtgactgac accgttcaag 1573381 aaatggctca gccaatcgta gacagccttc agctggaact cgttgacatt gaatttgtca 1573441 aagagggcca aagctggttc cttcgcgtgt ttattgattc cgatgacggt gtggatattg 1573501 aggaatgtgc caaagtaagc gaagctttaa gcgaaaagct tgatgaggca gacccaatca 1573561 gccaaaatta ctttcttgaa gtctcatctc caggagctga gcgtccgcta aagaaaaaag 1573621 ccgatttcga aaaatcacta ggaaaaaacg tatacattaa gacgtatgag cctattgacg 1573681 gcgtaaaagt gtttgaaggt gaactggctg aatttgatgg acaaacagtg acagttgaga 1573741 tcacgatcaa aacaagaaag aaacggatca atattccgta tgaaaagata gctaatgcaa 1573801 gattagctgt tacattctaa tgaatacaaa tgttttaagg ggggagaccg ttaaatgagc 1573861 agtgaattat tagatgctct cacgattctt gaaaaagaaa aaggcatcag taaagaaatt 1573921 atcatcgaag caatcgaagc tgcgttaatt tctgcttata agcggaattt taatcaagcg 1573981 caaaatgtac gggtggatct aaaccgtgaa actggctcca tccgtgtatt tgcaagaaaa 1574041 gatgtcgttg acgaagtata cgaccagaga ttagaaatct caattgaaga ggcacagggc 1574101 atccatccgg aatatatggt cggcgatgtc gtcgaaatcg aagttacacc taaggatttc 1574161 gggcgcatag ctgctcaaac agcgaagcag gtcgtcacac agcgtgtgcg cgaagctgag 1574221 cgcggtgtga tttattctga atttatcgac cgtgaagaag acatcatgac agggatcgtc 1574281 cagcgtctgg acaataaatt tatctacgtg tctttaggca aaatagaagc cttgctgccg 1574341 gttaatgagc aaatgccgaa tgaaagctac aagccccatg accgcattaa ggtatatatc 1574401 acaaaagtag aaaaaacaac gaagggtccg cagatttatg tgtcaagaac acatccaggc 1574461 ctgttaaagc gtttgtttga aattgaagtg cctgaaattt atgatggaac tgtcgagcta 1574521 aaatctgttg ccagagaagc cggcgaccgt tcgaaaattt ctgttcgcac agatgatcct 1574581 gacgttgatc ctgtcggttc atgcgtaggg cctaaaggcc agcgtgtgca agcaatcgtc 1574641 aatgaattaa aaggtgaaaa aattgacatt gtcaactggt ccagtgatcc tgtagaattt 1574701 gtcgcgaatg cgctcagccc ttccaaagtg cttgatgtca ttgttaatga agaagaaaaa 1574761 gcgacaactg ttattgttcc tgattaccag ctgtctctgg caattggaaa aagaggacaa 1574821 aacgcacgct tagctgctaa actgacaggc tggaagattg atattaagag cgaaacggac 1574881 gcaagagaac ttggaatcta tccgagagaa cttgaagaag atgatgagcc gctctttacg 1574941 gagcctgaaa ctgctgaatc ggatgaataa gaggtgactt taggtgaata aacacaaaaa 1575001 gatcccatta cgcaaatgtg tagtgactgg tgaaatgaag cctaaaaagg aactgatccg 1575061 agttgtacgg tcgaaagaag gcgaaatctc agtagacccg accggaaaaa agaatgggcg 1575121 gggtgcttat ttaacgctgg ataaagagtg catcttagca gcaaaaaaga aaaacacttt 1575181 gcaaaatcaa tttcaatcac aaatcgatga ccagattttc gatgaattgc tggaactggc 1575241 ggaaaaggtg aaaaaataaa atgtctggaa tggaatggtt tcccttgctg ggtctggcca 1575301 atcgagctcg taaggtcgtg tcaggcgaag acttggtaat aaaagaaatc aggaatgcgc 1575361 gtgcaaagct tgtcctgctt acagaggatg catcatctaa cacagcaaaa aaagtaactg 1575421 acaagtgcaa ttattataaa gtcccttata aaaaagtcga gagtcgcgcg gttcttggac 1575481 gctctatcgg taaagaagcc cgtgtcgttg tcgccgtcac tgaccaaggt tttgcgaata 1575541 agctgatcag cttgctcgat taatattttt gggggtgaac gaatggctaa aatgagagta 1575601 tacgaatatg caaaagcgtt aaatgtttca agtaaggaaa ttttgaccgc actgaagaac 1575661 atggatttag aagtgaataa tcacatggcc atgcttgaag aaaaggccat taaaaagcta 1575721 gatgccaaat ataaaaaagg cggcgcagct gctaaatctc aaaagccagc agaaacgaac 1575781 aaaaacaaac agccacaagg ggttaatcag caatcagctg gaaatcaacc aaataaaatt 1575841 cgagacggaa agaagaatga cgtgcagaat aatcaattta acaaaaacaa gaagaataac 1575901 aacaacaaaa aaaataaacg caacaacaac aataataaaa accaacatca gcaaaagcct 1575961 gtaaagccga aaaaagagct tcctgagaaa attacattct ctggcacttt aacagttggc 1576021 gcacttgctg aagagcttgg caaagagcct tcagaactca ttaaaaagct gatgcttctt 1576081 ggcgtaatgg caaccattaa ccaagagctt gataaagaca caatcgaact cattgcatca 1576141 gaatatggtg ttgaaacaga agaggtcatt gtgcttgaag aaacagagct ggaaaaatac 1576201 gaagagcctg ataatgaaga ggatcttgaa attcgtcctc ctgtcgtgac aatcatgggc 1576261 cacgttgacc atgggaaaac aacgcttctt gacagcatcc gtaaaacaaa ggttgttgaa 1576321 ggggaagcag gcggaatcac tcagcatatc ggcgcttatc aaattgaaga gaacggcaag 1576381 aaaatcacgt tcttggatac accgggccac gccgcattta caacaatgcg cgcacgcggt 1576441 gcagaagtaa ctgatattac gattcttgtc gtagctgccg atgacggtgt catgccgcaa 1576501 acagttgaag cgattaacca tgcaaaagca gcagaggttc caatcatcgt tgctgtgaat 1576561 aaaatagata aagaatccgc aaaccctgac cgtgtaatgc aagaactgac ggaatacgga 1576621 cttgtccctg aagcttgggg cggagaaacc atttttgtgc cgctttccgc tttaactgga 1576681 aaaggcattg atgagctcgt tgaaatgatt ttgcttgtca gtgaggtaga ggaactgaaa 1576741 gcgaatccga atcgtcaggc aaaaggaacg gttattgaag ctgaactcga taaaggcaga 1576801 gggtcagtcg cgacgttgct cgtacagact ggaacactgc atgtcggtga tccgatcgta 1576861 gtcggcaata catttggccg tgtccgtgca atggtcaacg acattggccg ccgtgtgaaa 1576921 actgccggcc cgtcaactcc ggttgaaatt accggtttga atgatgtccc tcaagcggga 1576981 gaccaattcc ttgtctttaa ggatgaaaaa acagctcgtt ctgtcggtga agcccgtgct 1577041 tcgaaacagc ttgaagagca gcgcagcgat aaagcgaagc tcagtcttga tgatttattt 1577101 gagcaaatta agcaaggtga tgtaaaagac atcaacctca tcgtaaaagc tgacgttcaa 1577161 ggatctgctg aagctttaac ggctgcactt caaaaaattg aagtagaagg cgttaaagtg 1577221 aaaatcatcc atacaggcgt tggtgcgatt actgaatcag acattatctt ggcatctgct 1577281 tccaatgcaa ttgttatcgg gtttaatgtg agaccggacg gaaatgctaa gagtacggct 1577341 gaagctgaaa atgtagatat tcgacttcac cgtatcattt acaaagtaat cgacgagatt 1577401 gaagctgcca tgaaaggtat gcttgatcct gaatatgaag aaaaagtaat tggtcaagta 1577461 gaagtacgcc aaacattcaa agtatctaaa atcggtacaa ttgccggcgg atatgttact 1577521 gaaggaacca ttacgcgcga cagcggcctc cgtttaattc gtgacggcgt cgtcatcttt 1577581 gaaggcgaag tagatgttct gaaacgcttt aaagacgatg tgaaagaagt ttcacaaggc 1577641 tatgaatgtg gtattacaat taagaaatac aatgacattc gtgaaggtga catccttgaa 1577701 gcgtttgtca tgcaagaaat tgaaagaacg tgatcggatt tgcggagtgt gaatgcatca 1577761 tttatgatgc aggatcgcta aaagaaaagc gtgccgttct gaagcggatt ttaaccaggg 1577821 ttcaaaacaa gttcaatgtt tcgatttcgg agattggcta tcaggacacc tggcaaagaa 1577881 ccagcttcgg aatcgccgct gtttcttcct ctcgcgttca aacagaaaaa gaactgcagc 1577941 gcgtcctagc gtttatcgat tcttttcctg aaattgaacg gacgatcact aggacagagt 1578001 ggttttaact tagaggtgat tgaattgagt atgagagcaa accgtgtcgg cgagcaaatg 1578061 aaaaaagaac tcggtgatat tatcagccgc aagctgaaag acccgagaat tggttttctg 1578121 acagtaacgg atgtacgtgt atcaggtgat ttgcaaattg caaaggtgta tatctcggtt 1578181 ctcggtgacg agaaaaaacg ggaagaagcg ctgaaagggc tggcaaaagc gaaaggattt 1578241 atccgatccg aaatcggcag ccgcatcaga cttcgaaaaa cgcctgaaat tgaatttgag 1578301 ttcgatgaat caatcgatta cgggaatcgg atcgaaacac tgattcacga attacattca 1578361 gagaaaccat ctgaataaaa aaagagagga taggcgtata tcgtctgtcc tctttcttcg 1578421 tttataagaa aaaaactcaa aagaaggagt gaaaggcaaa tggttaacgg agttctcctt 1578481 ttacataaac ctgttggcat gacatcgcac gactgtgtca tgaagatccg aaagctgtta 1578541 aaaacaaaaa aagtaggaca tacaggaacg ctcgatccgg aagtatcagg cgtgcttccg 1578601 atttgtgtag gaagagcgac aaaaatagtc gaatacttaa ctgaaaaatc taaaacgtat 1578661 gatgcagaaa taacattggg cttttcaacc acaacagagg atcaaaccgg agaaacggtg 1578721 gaaacaaagc ctgtcaatca cgacattgat aaagcggatg tagaaaaggt tttaaacagt 1578781 ttaaagggga aacaagaaca aattccgccc atgtattccg ctgtaaaagt aaacggcaaa 1578841 aaattatacg aatacgcaag agcagggatt gaagtagaac gtccgaaacg tatgataacc 1578901 attgaagaca ttgccctgac aacagagatt aaacatcatg gagaaaccgc aagcttccgg 1578961 tttacagtga cttgctccaa agggacctat gtaaggacgc tggcggtcat gatcggagaa 1579021 aagctcggat atccggccca tatgtctcat ttaatccgta cggcatccgg agatttttct 1579081 ctcgacgaat gctttacttt tgatgaactc gaagcacagg cccaatccgg aaccgtggaa 1579141 gagcatacag ttcctattga acgtgcgctc aatcatttgc cgaaatggat cataagtgat 1579201 acattagcta agaaagtaga aaatggggct ttgcttgaga cgcccgagca gttttctgaa 1579261 atgacaagtg gagaccgtat tgccgtcttt actgaatccg gaacctgctt ggcgatctat 1579321 ttccctcatc ctgcaaaaaa agggctgtta aagccggcaa aagtattgat gcaaaaaagc 1579381 gaacaataga aaaaaggtga ccgttctgtg aagacgatac atattacaca tcctcatcat 1579441 ttaataaaag aggagcaggc aaaatcagtg atggcgttag gttattttga cggcgttcat 1579501 ctcgggcatc aaaaggtaat cggcacagcg aagcaaatag ccgaagaaaa aggtctgaca 1579561 ttagctgtga tgacctttca tccccatcct tctcacgtgt tgggcagaga taaggaacca 1579621 aaggatctga ttacgcctct tgaagacaaa ataaaccaaa ttgaacaatt aggcacagaa 1579681 gttctgtatg tcgttaaatt taatgaagtg tttgcttctc tttctcctaa gcagtttata 1579741 gaccagtata ttatcggcct taatgtgcag cacgcagtgg caggctttga ctttacgtac 1579801 ggcaaatacg gcaagggaac aatgaagacc atgccggatg atttagacgg aaaagctggg 1579861 tgcacaatgg tagaaaaatt aacggagcag gataaaaaaa tcagttcttc gtatatccgt 1579921 accgcgcttc aaaacggaga tgttgaattg gcgaatgtct tgcttggaca accttatttt 1579981 attaaaggaa ttgtcattca tggtgataaa agagggcgga ccatcgggtt tccgacagcg 1580041 aatgtcggtt taaataacag ctatatcgtt ccgcccacag gtgtatatgc cgtaaaagcg 1580101 gaagtgaacg gcgaagttta caatggcgtt tgcaatattg gctataagcc aacgttttat 1580161 gaaaagcgcc ctgaacagcc ttccatcgag gtcaatctgt ttgatttcaa tcaagaggta 1580221 tatggagccg ctataaaaat cgaatggtac aaacggattc ggagcgagcg gaaattcaat 1580281 ggcatcaaag aattaactga gcaaattgag aaagataagc aggaagccat ccgttatttc 1580341 agcaatttgc ggaaataact tgcaacgcac gcaaatttta ttctaaaata tttgcatata 1580401 ggcacgattt ttagtatgat agttttcgta gtcttaaaac cattgcttgg caatccgaag 1580461 tcaccgacgg ttgctaggta actggggcta aatatgattt ggaggtgaaa caggatggca 1580521 attactcaag agcgtaaaaa ccaactcatc aatgagttca aaacacacga atctgatact 1580581 ggatctccag aagttcagat cgctatccta actgactcaa ttaacaactt gaacgagcat 1580641 ttacgtactc acaagaaaga ccaccactca cgtcgcggtc ttcttaaaat ggtaggtaag 1580701 cgtcgtaatc ttcttacgta tctgcgtaat aaagacgtaa ctcgttaccg tgagttaatt 1580761 aacaaactag gcttacgtcg ataatcgtaa aaagcgggag gattcccgct tttttatcgt 1580821 attaaagcga aatttcttat aacaaatcat tgaaatcctt ttacatacta ctttgacatt 1580881 gatatgttca attcatttcg ttcataatag gagtaattga ttatttcaca caacgaagag 1580941 aggagttcgt aattgtatgg gacaagaaaa acatgtcttt accatagatt gggccggaag 1581001 aacgcttacc gttgaaaccg gccagcttgc caaacaggca aatggtgctg tgatgatccg 1581061 ctacggtgat acagcagtac ttagtacagc aaccgcttca aaagaaccta aaccgcttga 1581121 tttcttccct cttactgtaa actatgaaga aagattatat gcggtaggga aaattccggg 1581181 cggatttatt aaaagagaag gacgtccaag tgaaaaagcg gttcttgcca gccgtttaat 1581241 tgaccgtccg atccgtcctt tgtttgccga tggattccgt aatgaagttc aagtcatcag 1581301 cattgtcatg agtgttgacc aaaactgctc ttcagaaatg gctgccatgt tcggttcatc 1581361 tcttgcactt tctgtatcgg atattccgtt tgaaggaccg attgcagggg ttactgtcgg 1581421 acgcattgat gatcaattta tcattaaccc gacagtcgat cagcttgaaa aaagcgatat 1581481 caatcttgtc gttgccggca cgaaagatgc gattaacatg gtagaagcgg gagcggacga 1581541 agttcctgag gaaatcatgc ttgaggccat tatgttcggc catgaagaga ttaaacgcct 1581601 gattgcattc caagaagaaa ttgttgcagc agtcggcaaa gagaaatctg aaattaagct 1581661 ctttgaaatt gatgaagagc ttaatgaaaa agtaaaagct ttggcagaag aggatctgct 1581721 gaaagccatc caagttcatg aaaagcatgc ccgtgaagat gccattaacg aagtgaagaa 1581781 cgcagttgtg gcaaaattcg aggatgaaga acatgatgaa gacacaatca agcaagtgaa 1581841 gcagatttta tccaagcttg tgaaaaatga agttcgccgc ctgattactg aagagaaagt 1581901 aagaccggac ggccgcggtg tcgatcaaat ccgtccgctc tcttcagagg ttggcctctt 1581961 gccaagaacg cacggttcag gtctatttac aaggggacaa actcaggccc tcagcgtatg 1582021 tacgctaggt gctctgggag atgtgcaaat ccttgacggc ttaggtgtcg aagagtcgaa 1582081 acggtttatg catcattaca acttcccgca attcagcgtt ggggaaacag gaccgatgcg 1582141 cggaccggga cgtcgtgaaa tcggacacgg agcactgggt gagcgtgcgc ttgagccagt 1582201 tattccgtct gaaaaagact tcccttatac tgtccgtctt gtttcagaag tgcttgaatc 1582261 aaacggttct acatctcaag caagcatttg cgcaagcaca cttgcaatga tggatgccgg 1582321 tgtaccgatt aaagcgccag ttgctggtat tgcgatgggt cttgtcaaat caggcgaaca 1582381 ttacactgtc ttgactgaca tccaaggcat ggaagacgcg ctcggagata tggactttaa 1582441 agtagcggga actgaaaaag gcgtaacggc cctgcaaatg gacattaaaa ttgaaggcct 1582501 ttccagagag attcttgaag aagcgcttca gcaggcgaaa aagggcagaa tggaaatcct 1582561 caacagcatg cttgcaacat taagcgaatc aagaaaagag ctttctcgat atgcgcctaa 1582621 gatcttaaca atgaccatta atcctgataa aatccgcgat gtcatcggac caagcgggaa 1582681 acaaatcaat aagatcatcg aagaaaccgg tgttaaaatt gatattgagc aggacggcac 1582741 aatctttatt tcctctacag atgaaagcgg caaccaaaaa gcgaaaaaaa tcatcgaaga 1582801 ccttgtgaga gaggttgaag tcggccaact ttacctaggt aaagtgaaac ggattgaaaa 1582861 attcggggct ttcgttgaaa ttttcagcgg aaaagacggt ttggtgcaca tttcagagct 1582921 tgcgcttgaa cgcgtaggga aagttgaaga tgttgtgaaa atcggagacg agattcttgt 1582981 caaagtcact gaaattgata aacaaggacg agtgaattta tcccgcaaag cggtgctccg 1583041 tgaagagaaa gaaaaagaag aacaacaatc ttaaatgaaa acataaaagg agcctgggag 1583101 acccggcttc tttattttga agcttttcaa aagcaggcgg gttctacctt gtccttctcc 1583161 ttcataatgt gaggtgaggg ggggacagaa catgtacaaa aaatttgtac cgtttgccgt 1583221 ttttttattt cttttttttg tctcatttga gatgatggaa aatccgcatg cacttgatta 1583281 tataggggca atgaaaaaag atacggtgac tgtcacggcg tcaaaagacc cgttatatga 1583341 agaattgctt caaaaagcgc cggagtacga agttaagccc cagaatgcaa gaattgataa 1583401 agtgtggaaa agcattccag gctacaatgg attaaaggtc aatattgaac aatcatataa 1583461 aaaaatgaaa cagcatggta agtttcggga aaaagatttg gtgtacagtc aagtaaaacc 1583521 aagtgttcat cttgagtcac ttcagcctga gcctatttat aaaggaaatc ctgacaaacc 1583581 gatggtggct tttttaatca atgtggcatg gggaaatgag tatttggaaa aaatgcttcc 1583641 tattctgcaa aagcaccagg ttaaagctac gttcttttta gaaggcaatt gggtgagaaa 1583701 caatgtacag ctcgctaaga agattgcaaa agacggacat gaaatcggaa atcattcata 1583761 caatcatccg gatatgagca aactgactac aggaagaatt tccgagcagc tcgacaagac 1583821 taatgaacaa atagaacaaa cgatcggcgt taagccaaag tggttcgctc cgccaagcgg 1583881 aagtttcaga aaagcggtta tcgacattgc agcagagaaa cagatgggaa cagtcatgtg 1583941 gacagttgat acaatcgatt ggcaaaagcc ggctccgtct gtacttcaga cgagagtgtt 1584001 aagcaagata cataatggtg ccatgatttt aatgcatccg actgacccta cggcggaaag 1584061 tcttgaagcg ctgattacac agataaaaga caaaggatat gcgcttggaa cagtcactga 1584121 actaatggat gaaacaagac tattgaagta acagatgaag gcagcttgtc tttgaatagg 1584181 aggaacaaat ttgattaaac gatatacgtg tcaaaatggt gtaagaattg tgctggaaaa 1584241 taacccgaca gtccgttctg ttgcgatcgg cgtatggatc ggcacaggtt cgagacatga 1584301 aacgccggag ataaacggaa tttctcactt tttagagcac atgttcttta aagggacgag 1584361 cacaaaatct gcacgcgaga tagcagaatc ttttgatcgt attggcggcc aggtcaatgc 1584421 gtttacttca aaggaatata cctgctacta tgcaaaggtg cttgacgagc atgcgaatta 1584481 cgcgctggac gtattagcag atatgttctt tcattcaacg tttgatgaaa acgagctgaa 1584541 aaaagagaaa aatgtagtat atgaagaaat taaaatgtat gaagatgcgc cggacgacat 1584601 tgtacatgat ttattgagca aagccactta cggcaatcat tctttaggct acccaatttt 1584661 aggaacggaa gaaacgcttg cttcctttaa cggtgactct ctcagacaat acatgcatga 1584721 ttattatacg ccggaccgag tggtgatttc ggtagcgggc aatatatctg acagttttat 1584781 caaagatgta gaaaaatggt tcgggtcata cgaggcgaaa ggcaaagcga caggccttga 1584841 gaagcctgag ttccacacgg aaaaactgac gagaaaaaaa gaaacagagc aggctcattt 1584901 gtgccttgga tttaaaggct tagaggttgg ccatgaacgt atttatgatt taatcgtcct 1584961 caacaatgtg ctcggaggca gcatgagcag ccggctgttc caagatgtgc gtgaagataa 1585021 aggacttgct tattctgttt acagctatca cagctcatat gaggacagcg gaatgctaac 1585081 gatttacggc ggaacgggtg caaatcagct tcagcagctg tcggaaacaa ttcaagaaac 1585141 cctggccaca ttaaaacgtg acggcattac ctcgaaagaa ctggaaaaca gcaaagagca 1585201 aatgaaggga agcttaatgc tgagcttaga aagcacaaac agcaaaatga gccgaaacgg 1585261 aaaaaatgaa ctgctgctcg gcaaacataa aacattagat gaaattatca atgaattaaa 1585321 cgccgtgaac ttagagcgtg ttaatggcct tgccagacaa ttgtttaccg aagactatgc 1585381 attagcactt atcagccctt ccggcaatat gccgtcttaa aaaggaaagc ctgccccata 1585441 atggagcagg cattttttaa tccctttcat catacatagt acaagggggt gacagacatg 1585501 cggctcagtg aattatcggg aaaggaaatt gtagacatca aaagagctga acggctcgga 1585561 gtgctcggcc agaccgattt ggaaatcaat gaacaggatg gacagattac agcactcctc 1585621 attcccacag ttaagtggtt tggtttgaga aagcaaggtc atgacattcg tgtcccatgg 1585681 caccatattc aaaagatcgg ttcagatatg attatattag atgtacctga ggaaatgcct 1585741 cctcgacaag agtaaatagc ccaattgact gtgaagcggg ctctaaagaa aacatctgaa 1585801 acatcggctg ccggagccga tgttttttta tatggaaaaa gcgcatcttt tatattcacc 1585861 ggtatttcct tttgatcata agatgaaggg gagcttaaca actagagatc cagtatatac 1585921 aaagaaggtg aacgtttaga atgttaaccg gattgaaaat tgcagttatc ggcggtgacg 1585981 caagacagct cgaaattata agaaagctca ctgaacagca ggctgacatc tatcttgtcg 1586041 gttttgacca attggatcac ggttttaccg gggcagtaaa atgcaatatt gatgaaattc 1586101 cttttcagca aatagacagc atcattcttc cagtatccgc gacaacagga gaaggtgtcg 1586161 tatcgactgt attttcgaat gaagaagttg tgttaaaaca ggaccatctt gacagaacgc 1586221 ctgcacattg tgtcattttc tcaggaattt ctaacgccta tttagaaaac attgcagctc 1586281 aggcaaaaag aaaacttgtt aagctgtttg agcgggatga cattgcgata tacaactcta 1586341 ttccgacagt agaaggaacg atcatgctgg ctattcagca cacggattat acgatacacg 1586401 gatcacaggt ggccgttctc ggtctggggc gcaccgggat gacgattgcc cgtacatttg 1586461 ccgcgctcgg ggcgaatgta aaagtggggg caagaagttc agcgcatctg gcacgtatca 1586521 ctgaaatggg gctcgttcct tttcataccg atgagctgaa agagcatgta aaagatatag 1586581 atatttgcat taataccata ccgagtatga ttttaaatca aacggtactt tctagcatga 1586641 caccaaaaac cttaatattg gatctggcct cacgtcccgg gggaacggat tttaaatatg 1586701 ccgagaaaca agggattaaa gcacttcttg ctcccgggct tccagggatt gtcgctccta 1586761 aaacagctgg gcaaatcctt gcaaacgtct tgagcaagct tttggctgaa atacaagctg 1586821 aggaggggaa ataaggatgt cgtcattaaa aggaaaaaga atcgggtttg ggctgaccgg 1586881 gtcgcattgc acatatgaag cggttttccc gcaaattgag gagttggtca acgaaggagc 1586941 tgaagtccgt ccggttgtca catttaatgt aaaatctaca aatacccgat ttggagaggg 1587001 cgcagaatgg gttaaaaaaa ttgaagacct gactggatat gaggccattg attcgattgt 1587061 aaaggcagaa cctcttgggc cgaagctgcc ccttgactgc atggtcattg cgcctttaac 1587121 aggcaattca atgagcaagc tggcaaatgc catgacggac agcccggtgc tgatggcggc 1587181 aaaagcgaca atccggaaca atcggcctgt cgttctgggt atctcgacaa atgatgctct 1587241 tggtttaaac ggaacaaatt taatgaggct catgtcaaca aaaaatatct tttttattcc 1587301 attcgggcaa gatgatccat ttaaaaaacc gaattcaatg gtagccaaaa tggatctgct 1587361 tccgcaaacg attgaaaagg cactcatgca ccagcagctt cagccgattc tagttgagaa 1587421 ttatcaggga aatgactaaa tttacagaaa atctttccca aactaaaaaa ttcggtcatc 1587481 acccgcatat tctatggtaa aataaaacgt aaaatcatag tcaaatcaat tcaatgaagc 1587541 tgattggcgg aaggagtttt acagatggga agaggtttac acgtagctgt tgtcggagcg 1587601 acaggggctg tgggacaaca aatgcttaaa acacttgaag acagaaactt tgaaatggac 1587661 acacttacat tgctatcttc aaaacgctct gcggggacaa aagtcacgtt taaaggccaa 1587721 gagctgactg ttcaggaagc ttctcctgag agctttgaag gggtaaatat tgctttgttc 1587781 agcgccggcg gaagcgtatc acaagcattg gcaccagaag ctgtaaaacg cggcgctatt 1587841 gttatagata atacgagtgc gttccgcatg gatgaaaata caccgcttgt tgtgccagaa 1587901 gtgaatgagg cagacttgca tgaacacaac ggcattattg ccaatccaaa ctgctctaca 1587961 atccaaatgg ttgcggcact tgaaccgatc cgcaaagcat atggcttaaa caaggtcatc 1588021 gtatcaactt accaggcagt atcaggagcg ggtaatgaag ctgtaaaaga gctttacagc 1588081 caaacacagg cgattttaaa taaagaagaa atagagcctg agatcatgcc tgtaaaaggt 1588141 gacaaaaaac actatcaaat cgccttcaac gcgattccgc aaatcgataa attccaagat 1588201 aacggctata cgtttgagga aatgaaaatg ataaatgaaa cgaaaaaaat catgcacatg 1588261 cctgaccttc aagtagcggc tacatgtgtg agactgccaa tccaaactgg gcactcagag 1588321 tccgtctaca tcgaaataga ccgtgatgac gctacagttg aagatattaa aaatctattg 1588381 aaagaagctc cgggcgtgac acttcaggat gatccaagcc agcagcttta tccgatgcct 1588441 gctgatgctg tcggcaaaaa cgatgtgttt gtaggccgca tccgcaaaga cttggacaga 1588501 gcaaacggtt ttcatttatg ggttgtttct gataacctat taaaaggcgc ggcatggaac 1588561 tctgttcaaa ttgcagaaag cctgaaaaaa ctaaacctcg tataaaagag agaattttct 1588621 aaagacgaat agaagagagt aaggcgctat cagcctgctc tcttctgtta cgtccgaata 1588681 atttggagtg aaaacagtga agataattgt tcaaaagttc ggcggaacat cagtaaaaga 1588741 tgataaaggc cgcaaactgg ctttagggca tattaaagaa gcaatcagtg aaggatataa 1588801 ggttgtcgtt gtcgtttcag cgatgggccg aaaaggggac ccgtatgcaa cagattcttt 1588861 gctcgggctg ctttacggcg atcagtcagc gatttctcct agggagcagg atttgctttt 1588921 atcttgcgga gagactattt cctctgtcgt ctttacaagc atgctgcttg ataacggtgt 1588981 gaaagcagct gcgctgacag gggctcaggc tggcttttta acgaatgatc agcatactaa 1589041 tgcgaaaatc attgaaatga aaccggagcg tttattcagt gtgctcgcca atcatgatgc 1589101 ggtagtcgtc gcaggcttcc agggcgcaac tgaaaagggt gatacaacaa caatcggcag 1589161 agggggcagc gatacgtctg cagccgcact cggagcagct gttgatgcgg aatacatcga 1589221 tattttcacc gatgtagaag gcgtgatgac tgctgaccca agagtggtag aaaatgcaaa 1589281 accgcttcct gttgtgacgt atacggaaat ctgcaacctg gcgtatcagg gggccaaggt 1589341 catttctccg cgtgctgtgg aaatcgcaat gcaggccaag gttccgatcc gcgtccgttc 1589401 gacttattcg aatgataaag gcacattggt gacatcacat cactcttcca aggtcggcag 1589461 tgatgttttt gaaaggctga ttacgggaat cgcccatgtc aaagatgtca cgcagttcaa 1589521 agtgcctgcg aaaatcggcc agtataacgt tcagactgaa gtgttcaagg ctatggcaaa 1589581 cgctggaatc agtgtcgatt tctttaacat tacacctagt gaaatcgtct atacggtagc 1589641 cggaaataaa acagaaacag ctcagcgtat tttaatggat atgggctatg atccaatggt 1589701 gacgagaaac tgcgcgaagg tatcggcggt cggcgcgggc attatgggtg ttcccggtgt 1589761 tacgtccaaa attgtatcgg ctctttcaga aaaagaaatt ccgatccttc agtcggctga 1589821 cagccatacg acgatatggg tgctcgtcca tgaagcggat atggttcctg ctgtaaacgc 1589881 tttgcatgaa gtgtttgaac tttcgaagta aatgtgattg aatcatgatg aggtgaataa 1589941 aatgaatttc ggaaatgtgt ctacagcgat gattacaccc tttgacaata aagggaacgt 1590001 agactttcaa aaactgtcta cactgattga ttacttgttg aaaaacggaa cggattcttt 1590061 agtagtagcg ggaacaactg gagaatctcc gaccctttca actgaagaaa aaattgcgct 1590121 ttttgaatat acggtaaaag aagtaaacgg acgggtgccc gttatcgctg gtactgggag 1590181 caacaacacg aaagattcca ttaagctgac aaaaaaagct gaggaagcgg gcgtggacgc 1590241 tgttatgctt gttaccccgt attacaataa accttctcaa gaaggaatgt accagcattt 1590301 taaagcaatt gcggcagaga catctcttcc ggttatgctc tataatgttc ctggccgtac 1590361 ggttgcttct cttgctcctg aaacgacgat ccgtttggcg gcagacattc cgaatgtggt 1590421 tgcgattaaa gaagcgagcg gagacctcga agcgattaca aaaattattg ctgaaacacc 1590481 tgaagacttc tatgtctatt caggggatga tgctctaacg cttccaattc tttcagttgg 1590541 aggtagagga gttgtgtcag tggcgagcca tattgcaggc actgatatgc agcaaatgat 1590601 caaaaattat acgaatgggc aaacagctaa tgcggcactg attcatcaga aactgctgcc 1590661 gattatgaag gaactgttta aagcgcctaa tcctgctcca gtcaaaacag cgcttcagct 1590721 gagaggtctt gatgtcggtt ctgtgcgtct gcctctagtc ccattaactg aggatgaacg 1590781 tctgagctta agcagcacga tcagcgaact gtaagaaaat ttcatacagt gaaacaaacg 1590841 cggtcattct cacattcagc tgagtttgac cgtttctttt acatattggt tttccctaaa 1590901 ccttctgctt tatcttgttt tctaaattta ctttcagtta taataggaac aagtgatgat 1590961 ggacgggtat gagactagga ggatatagat tttgaaaaag aaaaatacag aaaacgttag 1591021 aattatcgcc cttggcggtg tcggagagat tgggaagaac ctttatgtca ttgaaattga 1591081 ctcagacata tttgtcgttg atgccggcct tatgcatcca gaaaacgaaa tgctcggtat 1591141 tgatgtagtg attcctgaca tatcatattt gattgaacgg gctgaccgcg tcaaggcaat 1591201 ctttttaacg cacgggcacg atgaaaatat cggcggcgtt ttttacttat taaacaagct 1591261 gtccgttcca gtgtacggaa caaaactgac gcttgcactg ttaagagaga aattaaaaca 1591321 atacggacat aaccgaaaaa ctgatttaag agaaattcac tccaaatctg tcattacatt 1591381 tgaatcaaca aaggtatcgt tctttagaac gattcacagc attcctgatt ctgtaggtgt 1591441 gagctttaaa acatcacttg gatctattgt atgcacggga gacttcaaat ttgaccaaac 1591501 acctgcactt aatcagacgt gcgacattgg cgagatcgcc aagatcggca atagcggcgt 1591561 gctcgctctg ctttctgaca gtgcaaatgc ggaacggccg ggttacaccc cttcggaagc 1591621 ggctgtcagc ggagaaattt cggatgcgct gtataattca cagaaccggg tgattattgc 1591681 tgttttcgca tccaatatta accggattca gcaagtcatt catgcagcgg ctcaaaatgg 1591741 cagaaagatt gccgtagccg gaaaaaatct tcaatctgtc ctgcagctgg cgagaaagtt 1591801 aggatatatt gaagcagatg atgaattgtt tatttctgta caggatgtca aaaaatatcc 1591861 gaagcgcgaa gtggccatta ttacagccgg aagccaaggt gaaccattag ctgctttgac 1591921 aagaatggca aacaaagctc acaaacagct gaacattgaa gaaggggata cggtggtcat 1591981 tgcgtcaact ccgattcccg ggcaggaact catttactct aaaacagtag atcttcttgc 1592041 gagagccggt gcacaagtca tctttgccca aaagcgtgtt catgtatcag gccacggctc 1592101 acaagaagag ttaaagctga tgatcaacct gcttaaacca aaatatttga ttcctgtaaa 1592161 cggcgaatac agaatgcaaa aagctcattc aaaaatcgct gaagaaaccg gcatgaagcg 1592221 cagtgacatc ttcttaattg aaaaaggcga cgtcgttgaa ttccgcggcc aaaacgtaaa 1592281 aattggggat aaagttcctt acggcaatat tttaattgat ggtttaggtg tcggtgatat 1592341 cggcaatatc gtattgagag accgccgctt gctttcacag gacggaattt taatcgttgt 1592401 cattacactt gataaacaaa agaaacatct tgtatcagga ccagaaatta tcactcgcgg 1592461 ctttgtttat gtaagagagt ctgaaggtct tatcgtacag gctactgagc ttgtacggtc 1592521 catcgtgaca gaagcgactg aaacatcaaa tgtcgaatgg tcaacgctga agcaggcaat 1592581 gcgggatgct ttgaaccaat tcctttatga aaaaacgaaa cgtaaaccga tgatcatccc 1592641 aattattatg gaagtataat gactgactaa agaccggagc tgctccggtc tttatttttt 1592701 gtccttcaag ccgggattga atgaagtatc tttgttcata atacaaagag aaactcggaa 1592761 aggatgaaag cgagatggat catcgtatgg aaaacacaga agaagagcgt cctgaaaaaa 1592821 atgatgcgaa ggacagcatt atgaataaaa tacagcagct tggtgaaacg acgcttccgc 1592881 agctgcccca agatacaaat attcattgtc tgaccattat cggacaaatt gaaggccatg 1592941 ttcagcttcc tccgcaaaac aaaacaacaa aatatgaaca tgtcatcccg cagattgtgg 1593001 caattgaaca aaatcccaaa attgaaggct tgctgatcat attaaatact gtcggaggag 1593061 atgttgaagc tggtcttgcc atagcggaaa tgcttgcatc tttatcgaaa ccgaccgttt 1593121 ctatcgtgct tggcgggggg cattcaatcg gcgttccgat tgctgtatcc tgtgattaca 1593181 gctatatcgc cgaaacagca acgatgacga ttcatccagt taggctcacc gggctggtca 1593241 tcggggtgcc gcaaacgttt gaatacctgg ataagatgca agaaagagtt gttaaatttg 1593301 tgacaagcca ttccaatata accgaagaga agtttaaaga gctaatgttt tcaaaaggaa 1593361 acttaacacg cgatatcgga acaaatgtag tcggtaagga tgcagttaaa tacggattga 1593421 tcgatcacgc aggcggtgtc ggacaggcaa tcaataaact gaatgagctc atcgatgaag 1593481 caaggaaaga agaaggacgg atgattcaat gattctttat accgtgatgc ctcaggaaat 1593541 tgtgtttgca gaacagaacc aagagacaag cgcacatgag caaattgaat ataaaggtgt 1593601 accgcttcta gtcgaaatga aagggaatga agcggaagtc attcaaatca tgagcaccaa 1593661 tccaatgcat tttctgcatc cggacatttc accgggacaa aagctgaaat taaacgtata 1593721 agaatccaac ccttttttaa gggcaaaata tgctataata ggggaatcct acagaaaaaa 1593781 cgcagcctgt aaacggctgc tttcttcatt atgtatgaac ttacattttt taacgcagta 1593841 aggtgatgag tgtggcaaag aaaaaacgaa aatcaagaaa aaaacaggcg aaacagctca 1593901 atataaaata cgagctcaac ggattgctgt gtatagccat ttcaattatc gcaatcttgc 1593961 agctgggggt agtcgggcaa acgtttatct atttgttccg cttttttgct ggagagtggt 1594021 ttattttatg cttgttaggt ttattggtgt taggagtctc actgttttgg aagaaaaaaa 1594081 ccccaagcct tttaacgaga cgaaaggccg ggttgtactg tattatcgca agcatattgc 1594141 tgctttctca cgtgcagcta tttaaaaatt tgacgcacaa agggtctatt gagtctgcaa 1594201 gcgtggtgcg caatacgtgg gaattgtttt taatggacat gaatggcagc tctgcttcac 1594261 ctgatttagg cggagggatg atcggtgcgc tgctgtttgc ggcttcacac tttttgtttg 1594321 cgtcgactgg ttctcagatc atggcaattg tcatgatttt gatcggaatg attttagtaa 1594381 caggacgctc gctgcaagaa acgctaaaaa agtggatgag cccgattgga cgttttataa 1594441 aagaacaatg gttagcattt attgatgaca tgaaatcctt caaatcaaat atgcagtcat 1594501 cgaaaaaaac gaaagcgccg agcaaaaaac aaaaaccggc ccgcaaaaaa cagcaaatgg 1594561 aaccggagcc tcctgatgaa gagggggatt atgaaacagt atcgcctctt attcattcag 1594621 agccgattat ctcaagcttt tctgatcgta atgaagagga agagtctcca gttatagaaa 1594681 agcgcgccga acctgtgtcg aagccgcttc aggacatcca accggagaca ggtgatcagg 1594741 aaactgtttc tgctcctcct atgaccttta cagagctcga aaataaggat tacgagatgc 1594801 cgtcactgga tttgctggca gatccgaagc ataccggcca gcaggctgat aaaaagaata 1594861 tttatgaaaa tgcgagaaag cttgaacgca cattccaaag ctttggcgta aaggcgaaag 1594921 tcacacaggt tcatctcgga ccggccgtaa caaaatatga agtatatcct gatgtcggag 1594981 tgaaggttag caaaattgtc aatttaagcg atgatttagc gcttgcgctt gctgcgaagg 1595041 atatcaggat cgaagcgcct ataccaggca aatcagcaat cggaattgaa gttccaaacg 1595101 cagaagtggc aatggtttcg ctgaaagaag tgctggagtc taaattgaat gacagaccgg 1595161 atgcgaagct gttaattgga ctcggccgca atatttcagg tgaagctgta ttggctgagt 1595221 taaacaagat gccccacctt ttggtcgcag gcgcaaccgg tagcgggaaa agtgtctgtg 1595281 tcaacggcat tattacaagt attttaatgc gggcgaaacc gcatgaagtg aaaatgatga 1595341 tgatcgatcc taaaatggta gagctaaatg tctacaacgg gattccgcat ttgcttgctc 1595401 ctgttgtaac cgatccgaaa aaagcgtcgc aggctttgaa aaaggttgtc aatgaaatgg 1595461 agcggcggta cgaattattt tctcatacgg gtacaagaaa tattgaagga tacaatgatt 1595521 atataaaacg cgccaacaat gaagaaggag cgaaacagcc agagctgcct tatattgttg 1595581 tcattgtgga cgagctagcc gatctcatga tggtcgcttc atctgatgtg gaagattcga 1595641 ttacgagatt gtcccaaatg gcgcgggctg ccggcatcca tcttattatt gcgacacagc 1595701 ggccatcggt ggatgttatc acaggggtga tcaaagcgaa cattccgtca cgaatcgcgt 1595761 tcagcgtatc ttcacagacg gattcaagga ccattcttga catgggtggc gctgagaagc 1595821 ttcttggccg cggcgatatg ctgtttttac ctgtaggggc taacaaacct gtccgtgtgc 1595881 agggagcatt tttgtcggat gacgaagtgg agaaggtcgt cgaccatgtg attactcagc 1595941 agaaagcgca atatcaagaa gaaatgattc ctgaggagac gacggaaact cattccgagg 1596001 ttactgatga actttatgat gaagctgttg aattaatcgt cggcatgcag acggcatctg 1596061 tttcaatgct gcaaagaaga ttcagaattg gctatacgag agcggcgcgc ctgattgacg 1596121 caatggagga acgcggtgtt gtcggaccgt atgaaggcag caaacctagg gaagtattat 1596181 tatcaaaaga gaaatatgat gagctctctt cttaatgaag ggagttccgc tttctatagt 1596241 tgtcaataat gatattatgt aaactgatca cctttctatt tattttttcg acaaaacatg 1596301 atatagttgt cccaattgtt caataatttt tatcgaaagt ggtttacgga ggggaaacat 1596361 gtctacaaaa gctgataatc ggcacttgta tttgaaagta attgaacgaa ttaaagagga 1596421 tataaaaaat gggatctaca ctgagaagga aaagctgcct tctgaatttg agctttccaa 1596481 aaagcttggt gtcagcagag cgacgctaag agaagccttg cggatactgg aagaagagca 1596541 tgtgattatc agaaggcatg gtgtaggcac ttttgtccat tctaagccgt tatttctttc 1596601 gggtattgaa cagctgaaca gtgtaaccaa gatgatagaa caggcgaata tgacccctgg 1596661 cacgattttt ctatcatcac aagtgcttat gccgtctgaa gatgatacga agagatttca 1596721 cttggcagaa gggcaagaac ttttttacct tgaacgagtc aggacagctg acggacagcc 1596781 gattgtgtat tgtatagaca aaattccgat gaatattttg ccgaattctt tttctcatca 1596841 gcaagaatct atgtttgacc tgctagagaa aaattcaggc tccgtaatca gctatgcagt 1596901 aactgatata gaaccgatcg gctatcacga taccatttct ccagtgcttg aatgcgatcc 1596961 ggaaacagct cttttgctgt taaaacaaac ccattacgat cagcacgata aaccggtgct 1597021 ttattcttta aattatttta gagcggataa attcagattt catgttttgc gtaaacgatt 1597081 ctaaaaacgg acgcctgtat gtgtctgttt ttttatttgc actgattcat gtttctttgt 1597141 acatactttc attccggtta acgcaatata taagggatga caagaaagtg aatgggtgaa 1597201 aatgttgaga gagaaaaatg gaatgaaaaa tattattgca ttgtcttctg tcccgcttgt 1597261 gatgacactc gggaactcca tgctgattcc tgttcttccg atgatggaga aaaagctgtc 1597321 tgtgacttca tttcaagtat ctttaatcat tactgtatat tcagtagtag caattatttg 1597381 cattccgatt gccggatatt tgtcggatcg tttcgggaga aaaaaaatat tgcttccatg 1597441 cctcctcatt gcaggattgg ggggagccgt agctgctttt gcctcgacct atatgaaaaa 1597501 tccttatgct atgatcttgg cggggcgggt tcttcaaggc attggttctg caggtgccgc 1597561 tccgattgtc atgccgttta tcggcgacct gtttaaagga gacgatgaaa aggtcagcgc 1597621 gggtcttggc gatattgaaa ccgccaacac gtcagggaag gtactgagtc ccatacttgg 1597681 agccttactg gcttcttggt attggtttgt accgttttgg tttattccgt ttttctgttt 1597741 gatcagcttt ttgctcgtat tgtttttggt ggccaagcct gaagaagatg aagatgcgcc 1597801 tgctgtttct gagtttatta agagtgtgaa gaaaattttt aaacaggatg gtcgctggct 1597861 ttatacggtc ttcattatcg ggtgtgtcat tatgtttttg ttatttggcg tattatttta 1597921 tttatcagat acgctggaga acaagtatgc tattgacgga gtagctaaag gcggattact 1597981 ggcaatccca cttttgtttt tgtcaaccag ttcttttata gctggcaaaa agatcggtaa 1598041 agataaaggc cgaatgaaat tttgcgttgt tacaggaatg attctgttaa ccctttcgtt 1598101 tattgccttg tggtggaacc acagttttta ttttttattt gtctttttaa gctttggcgg 1598161 gattgggatt ggaatggctc ttcctgcttt agatgcattg ataaccgaag ggattgaaag 1598221 tgaacaatgc ggaaccattt cctcctttta caatagcatg cgctttatag gagtagctct 1598281 cggtccacct gtttttgctg cattaatgtc taatgcaaac tggattattt tcatactctc 1598341 ggcgttttgc agcatcgttt ctttattttt agtgctcttt actgtagatg ctaaaaaaag 1598401 tgaagaagaa aaaaacttag ggacggtcta gccagccgtc tttttttgcg ctttcttgca 1598461 cagtttacaa ctgtacctat acagcatgcg gaggttattg tttccttata aatcctacag 1598521 ttgctataat tacatgaaag agtgtttctg cggatgctga aaattggtca taatacatac 1598581 taattaagaa atgaacgaag gaggttccat atgtcatatg ttaatgaact caaatcaaag 1598641 cacggcggtt taaccgcaca cattgtaaaa acagaaaaat tcaaaaccgt ctcgcttatt 1598701 tttaagatgc ttgcgccgct gacaaaggat caagtcacca aaagagcgct tctcccgcat 1598761 gtgcttcttc gcggaacgaa aagccatccg aaaaccgcag gattgcgttc atacttggat 1598821 gagctgtacg gcacgtcagt atcggctgat cttacgaaaa aaggagagcg gcatgtcatt 1598881 acgttcaggc ttgaaatccc gaatgaaaaa tatttaaaag accaaacgcc gcttctcgag 1598941 aaagggctcc agcttctcgc agaactcgtc ttttcacctg ctttggaggg agacgctttt 1599001 cagtcacaat atgtggctca agaaaaacgg acgcttaagc aaagaatcca agccgtctat 1599061 gatgataaaa tgcgttattc gaatttaagg ctgatacagg aaatgtgcaa aaatgatcct 1599121 tacgcgcttc atgtcaatgg tgaaatcgac gatgtcgatg acattacggc agagcaatta 1599181 tacgaaacat accaaagcgc tatccaaaaa gaccagcttg atctatatgt tgttggcgac 1599241 gtggacagta accaggtaca atcggcaatt gataagtatt tcaaaacaga agagcgcact 1599301 cttggcatga ttgaaaacaa tcacgctgat gaaaaagttc agccaaaaga agtaattgat 1599361 gaagaggatg tcaagcaagg aaaactgaat atcggctacc gcaccagcat cacttataca 1599421 gatcaggatt atcctgcttt acaagtgttt aacggattgt tcggcggatt ctctcattct 1599481 aaacttttca ttaatgttcg ggaaaaagcc agtcttgctt actacgcggc ttcgcgtata 1599541 gaaagtttta aaggcttgtt aatggtgatg tcaggcattg aagtgaaaaa ttttgaacag 1599601 gcggtttcga ttattgctga gcaattccag gcaatgaaaa atggcgattt cagtgagcag 1599661 gatatagcac agacaaaggc cgttattcga aatcaagtgc tggaaacgat tgatacagca 1599721 tacggtttat ctgagttttt atatcagcag gccgctgctc aagtcgagat tcctatcgaa 1599781 gactttcttg ccaatattga gaatgtcaca aaagaggata tcattaaagc cggcgaaaag 1599841 attcagcttg atacgactta tttcttaaaa gggacggagg gtgcatcttg atcaaaccaa 1599901 tcgaatatga acagcttcag gagacgctgt atcatgaaaa aatgtccaac ggccttgatg 1599961 tttacgtttt gccgaaaaaa ggcttcaaca agacatatgc ggtctttaca acaaagtacg 1600021 gctcgataga taaccggttt gtccctttag gtaaaaacga gatggttcac gtgccggacg 1600081 ggattgctca ctttcttgag cacaagctgt ttgagaaagc ggacggagac gtttttcaag 1600141 atttcagcaa acagggggct tctgccaatg cgtttacgtc atttacaaga acggcttacc 1600201 ttttctcaag cacatcaaat gttgaacgca atttagagac gcttatcgat ttcgtacagg 1600261 acccatattt tactgaaaaa acggttgaaa aggaaaaagg gattatcggg caggagatta 1600321 atatgtacga cgataaccct gattggaggc tttacttcgg ggtcattgaa aacatgtaca 1600381 aagagcatcc tgtcagaatt gacatagcgg gaacagtgga aagcatttca catattacaa 1600441 aagaccttct ttatgaatgc tatgaaacgt tttatcaccc gagtaacatg ctccttttca 1600501 ttgtcggccc tgtagatcct gaagcgatta tttctcaggt aagagaaaac caggggaaaa 1600561 agccgtatac tgatcagccg gagatcaaac gagaagaagt gaaagagcaa gaagcggttt 1600621 tccgaaaaga aaaagagatc aaaatgaacg tgcagggacc gaaatgcctt gttgggctga 1600681 aatccaaaaa tccgtttaaa ttaggcaaag agctcttaaa gcatgaactt tcaatgaact 1600741 tattgcttga agctcttttt ggcaaaagct ctgcccagta tgaatcactt tatgaaaaag 1600801 gatatattga cgaaacgttc agctttgatt ttactgctga atatgggttc ggttttgcgg 1600861 cgatcggcgg agatacgcct gagcctgatc aattggctga agacatttca agcatgcttt 1600921 tgcgcgccgg tgaactgatt actgctgaaa agattgaact tgccagaaag aaaaagatcg 1600981 gcacattctt aaaagcgctg aattcccctg aatacatcgc caatcaattt acccgttatg 1601041 cgttcttgga tatgagcctg tttgatgttg taacggtact cgagcagatt accctcgagg 1601101 atgtccagaa cgtaatacaa gaggaaatcg ctgcagacag actgactgtc tgcaaggttg 1601161 ttcctaaatc ataaacaaaa catccctcca gtgtgagggg tgtttttctg cggaaagaag 1601221 gaaagaggat gaacaaaaca gcactaatca ccggagcaag cggcggcatt ggcaaaagca 1601281 tcagcgaaac ccttgcagct agaggataca atctgctgct gcattacaat acaaatcaaa 1601341 acgcggcagc ggagcttgct gaaaaactaa gtcagatgtt tggcgtaaat gcggagatat 1601401 tacaagctga cctgtccgcg caagatggag cagataagct gacaagttca attgttcagc 1601461 cgattgatgc gattgtttta aacagcggac gaagccattt tgggctgatt acggatgtag 1601521 ataacgcaac ggtccaggaa atggttcagc ttcatgtggc gagtccgtat atgctgacga 1601581 gaaaccttct gccaggcatg attcggaata aatcgggagc gattgtggct gtcagctcga 1601641 tttggggaga gactggagca tcctgtgaag tgttgtacag catggcaaaa ggagctcagc 1601701 attcatttgt aaaaggattg gctaaggagc tggcgccaag cggaatcaga gtaaacgccg 1601761 tagcgccggg tgcagttgat acaaatatga tgaatcaatt taccccggct gaaaaagaag 1601821 agatcgctga tgagattccg atcggccggc tggcccggcc gcaagaaatt gcggatgcaa 1601881 cagcttttct cctgtctgaa aaagcgtcat atatcaccgg ccaaattctg tcggtgaatg 1601941 gcggctggca ctgctgatcc gaaaatattc ggtgtatagt ttcttttgcg aaggacacaa 1602001 taatcttgta acttcacatg aaatggagga aacaagcatg tcagtattag aaaactggga 1602061 tagctggaaa aacttccttg gcgaccgtct gaactatgcg caagataaag gtatgagcca 1602121 ggatacgatt acagatcttg cgacagaaat cggcagctac ttggctaatg aagtggaatc 1602181 taagaacgag caggaaaaag tgctggcaga tctttggagt gtagcatcaa aagatgaaca 1602241 gcacgccatt gccaatatga tggttaagct tgttgaaaat aacagcactc actaggaaga 1602301 gaggggattt ttcctctctt ttttatgttt tcctcatcac agcaacattc ttctttctaa 1602361 ttagagaaaa atgctttatg ataaaggaag gtaaaatttt gccacaatga agggggtata 1602421 tcatttggca aagctcgaat ggtattttga atatgaaatt caagtgaacc gccccggact 1602481 gctcggggat atttcatctc ttcttgggat gctttctatc aacatcgtaa cgataaacgg 1602541 cgtcgatctt tccagaaggg gaatgctcct caggtgccgc catatagatc aaattaaacg 1602601 attagaatca atcttaaaaa cgatggaaac aattaaagta acgaagctta gagaaccgag 1602661 gcttcgcgac cgtcttgccg tacgccacgg ccgttatatt caacgggatg ccgatgacaa 1602721 gaaaacgttc cgctttgaac gggacgagct tggcttatta gtcgatttta tggccgaatt 1602781 gttcaaaaaa gaaggccata aattaatcgg aatcagaggt atgccgcgtg tcgggaaaac 1602841 ggaatcgatt gtagcctcta gtgtgtgcga gcaaaaggtg gctgtttgtg tcatcaacct 1602901 tgctgaagca gacgataaga agccagctga ttgccgatga atacagcact gaaaatgtct 1602961 ttatcgttga cggaattgtg tcaacacgaa gagggtcaga acgccatctc cagctggtcc 1603021 gagaaatcat gcggctgcct gcaacaaaag tggtggagca tccggacata ttcgttcaaa 1603081 atacagagta tacactagat gactttgatt atattattga actgagaaat gaccctgatg 1603141 aggttattac atatgaacat gccgaggaac cccaaatgtt tgatcaatcc gggttttcaa 1603201 gctttgattt ttaaaattgg aaggtgtttg ttgtgactga actaggaatc cggctcaaag 1603261 aagccagaga ggaaaaagca atgtcattgg atgatctcca agcggcaaca aagattcaaa 1603321 aaaggtattt aaccgccttg gaggaaggaa actatgacat tattccgggg aagttttatg 1603381 ttcgggcatt catcaagcaa tatgcagaag ccgttgggct tgatgcggat cagctgtttg 1603441 aggagcataa aaaagatatc cctaatacgt atcatgatga tgtgtctgaa aagatctccg 1603501 gcatgaatct tcaaaaggaa atgccaaagc cagcatctaa ggcgctggag ctgctgccaa 1603561 caatacttgt tattctcggc gtgattgtcg tgattgccat tgtgtacgcg atcattcaat 1603621 ttgccaatca caaaaacagt gatgatcaca atgcggcatc agaaaaagca attacgcaaa 1603681 gtgagagcaa gtacgaaatc cctaaagatt caacgctgaa agagaatcaa aataacagct 1603741 ctgaaaaaga gacagacact aaaaaagaaa cgaaagaaaa cgaagataag aaaaaagaaa 1603801 atgacagtga gaagctggag attaaagctg ctggcactga aggatcgtta acgacttatg 1603861 aagtgtccgg cgctgataaa atcgagctgg aactgaaggc atcagacagc tcctggatta 1603921 gagtgcgcga tgaaaacagc agctctttaa aagaaggaac gctgaaaaaa gacgaaacct 1603981 ataaaaaaga cataactgat cagaaacaag ttgatatccg caccggatat gcacctaatc 1604041 tgaaaataaa aatcaacggt aaggttcttt catatgaact tgatccgaaa aaagtgatgg 1604101 cacaaaccat aaagattgta aataaaaagg aagaaaagtc atcttaatta ccagatgact 1604161 tttcttcacg tccgagtatg aaattggagg ggctttatgt ttaacttacc aaataaaatc 1604221 acactagcta gaatcgcatt aatcccaatc ttcatgatta tcatgctggc gccgtttgac 1604281 tggggcaggc tcgaagttgg agacgaatcc atcccggtcg cacatttggc gggggccatt 1604341 ctatttatta ttgcatctac aacagactgg gtggacgggt attatgcccg aaaattaaat 1604401 ctcgtaacaa acttcgggaa atttcttgat ccgcttgcgg acaaactgct cgtatccgca 1604461 gcgttaatta tccttgttca atttgatctc gctccagctt ggatggtcat tgtgattatc 1604521 agcagggagt ttgccgtgac aggtttaagg cttgtcttag ccggaacagg agaagtcgta 1604581 gctgctaaca tgcttggtaa aatcaaaacc tgggcacaga ttattgcggt atctgcattg 1604641 cttcttcata atcttccatt tgaacttgtg tcattcccgt ttgcagactt ggcgctgtgg 1604701 gtagccgtct tctttactgt cgtctcaggc tgggaatatt tctctaaaaa ttgggaagcg 1604761 ttaaaaacat ctaactaaga aagaaggact tcgtcatgga atttccaaaa aaagcagaaa 1604821 taattgcagt cggttcagag ttgctgcttg gtcaaatcgc caatacaaat gctcaattta 1604881 tcagcaaaca gctcgctgaa atcggggtca acgtatttta tcatacagcg gtcggagata 1604941 acccggagcg gctgaagcag gtcatccgca ttgctgaaga acgctctgac ttcattattt 1605001 tttcaggagg gcttggaccc acaaaagatg atctgacgaa agaaacgatt gcaaatacgc 1605061 tgggacgtcc gcttgtgtta aatgatgagg cattccaatc cattgaggac tatttcaaac 1605121 gaacaaaacg cacgatgtca cctaataacc gaaaacaggc gcttgtgatc gaaggctctg 1605181 acgtgctggc gaatcacttt ggaatggccc cgggaatgct cacagagcat gaatcgcgct 1605241 attatatgct tcttcctgga ccgccgagcg aattgcgtcc aatgtttgaa aacgaggcaa 1605301 agcctcttct gctgaaaaag atgggttcaa atgaaaaaat tgtgtcaact gttcttcgct 1605361 ttttcggtat cggtgaatct cagcttgaag ccgatttgga agatattatt gatgcacaaa 1605421 ccaatccgac aattgcgcct ttggcggctg atggagaggt gacgctgcgt ctgacagcca 1605481 aacacgccga tgaaaaggaa acagagcgtc tgttaaaaga aacagaggcc gttatcttag 1605541 agcgtgtcgg tgaatttttc tatggttacg atgatacttc tcttgtaaaa gagctatcta 1605601 tagcatgtaa ggaaaaaggc ataacaattt ctgcggcaga aagctttacc ggagggctgt 1605661 tttctgaatg gctgacggat catagcggtg cctcaaaatt atttgccggg ggcgttgttt 1605721 gctatacaaa cgacgtgaag cagaatgtgc ttggtgtcaa gaaggaaaca ttagatcgtt 1605781 ttggggcggt cagcaaggag tgcgcatccg aactggctaa gggtgttcaa aaactcactg 1605841 gcagcgatat cggcattagc tttactggtg tagcaggacc tgatgctcaa gaagggcatg 1605901 agcctgggca tgtgtttatc ggcatttccg caaatggtaa agaagaggtt cacgagtttc 1605961 actttgcggg ctccagaacg gggatcagaa aacgcggcgc taaatacggc tgccatttaa 1606021 tcttaaagct tttagagcaa aaataatatt ttcagcacat tatcctccta agaaaacatg 1606081 atttctctga tacattatga tattttgata ggaatcacgc caagaaaaaa tccgaatatg 1606141 cgttcgcttt tttcttggca aatcccttca aacagggtat agtatatgta gtggtaacat 1606201 aaaggaggaa aaaatagaat gagtgatcgt caggcagcct tagatatggc tcttaaacaa 1606261 atagaaaaac agttcggcaa aggttccatt atgaaactgg gagaaaagac agatacaaga 1606321 atttctactg taccaagcgg ctccctcgct cttgatacag cactgggaat tggcggatat 1606381 cctcgcggac ggattattga agtatacggt cctgaaagct caggtaaaac aactgtggcg 1606441 cttcatgcga ttgctgaagt tcagcagcag ggcggacaag ccgcgtttat cgatgcggag 1606501 catgcgttag atccggtata cgcgcaaaag ctcggtgtta acatcgaaga gcttttactg 1606561 tctcagcctg acacaggcga gcaggcgctt gaaattgcgg aagcattggt tcgaagcggg 1606621 gcagttgaca ttgtcgttgt cgactctgta gccgctctcg ttccgaaagc ggaaattgaa 1606681 ggcgacatgg gagattcgca tgtcggttta caagcacgct taatgtctca agcgcttcgt 1606741 aagctttcag gggccattaa caaatcgaag acaatcgcga ttttcattaa ccaaattcgt 1606801 gaaaaagtcg gtgttatgtt cgggaacccg gaaacaacac ctggcggccg tgcgttgaaa 1606861 ttctattctt ccgtgcgtct tgaagtgcgc cgtgctgaac agctgaaaca aggcaacgac 1606921 gtaatgggga acaaaacgaa aatcaaagtc gtgaaaaaca aggtggctcc gccgttccgt 1606981 acagccgagg ttgacattat gtacggagaa ggcatttcaa aagaaggcga aatcattgat 1607041 ctaggaactg aacttgatat cgtgcaaaaa agcggttcat ggtactctta tgaagaagag 1607101 cgtcttggcc aaggccgtga aaatgcaaaa caattcctga aagaaaataa agatatcatg 1607161 ctgatgatcc aggagcaaat tcgcgaacat tacggcttgg ataataacgg agtagtgcag 1607221 cagcaagctg aagagacaca agaagaactc gaatttgaag aataaaaata aaataagttt 1607281 caaatgatac aaaaggctga gtgaaaaact cagctttttt gtattttgca aaaaaatgat 1607341 aaaaatattg ctttttttga caactttttt agggctttat tcgtctaaca aaacgtgtgc 1607401 aaaatggaat ttattttggg aggaaaaaat gaatgacaag cccaacccgc agaagaactg 1607461 cgaaacgcag acggagaaaa ctaaataaaa gaggaaaact gttgtttggt cttttagcag 1607521 tgatggtttg cattacgatt tggaatgctc ttcatcgaaa tagtgaagaa aacgaaccat 1607581 ctcaagaaac tgcagcggtt tcaaataccg atcagaaaaa agaggtcaaa aagaaaactg 1607641 ccaaaaaatc agaggaacaa atcaaaacag tggatcgaaa ccaaaaaatc agcaattatt 1607701 taaaagagat cggtttcagc ggaacagcca tgattgtcag aaatggagaa atcgtaacaa 1607761 ataaaggttt tggctatgct gaccgtaaac actacattca aaataatcca ttgacatctt 1607821 tttatgtcgg ttcatcacaa aaagcgctga ttgcaactgc tattttgcag cttgaggaaa 1607881 aggggaaact tcagacaagt gatccggtaa gcacgtattt acctcatttt cccaacggac 1607941 aaacgattac tttgaagaat ctgcttacac atacatcggg gataaacgga catattgaag 1608001 gaaacggcgc cattactccg gacgatttaa taaaagatat agaacttcag ggaatcaaac 1608061 gtcagccggg cgtatgggac tacaaggatt ccaactattc tgttcttgct tatattattg 1608121 ctgaagtaag cggtgagccc tatgaacagt acataaagaa tcatattttt aaacctgcgg 1608181 gaatgacgca tgcaggcttt tacaaaacat atgaaaaaga accttatcct gccgtcgggt 1608241 ataagatgga gggcagcaaa acagttacac cgtatatacc tgatttatcc cagctgtatg 1608301 gagcgggtga tatttatatg agcgctatag atatgtacaa atttgaccaa gcgctgatag 1608361 acggaaaact gtattcgcaa aaaagctatg aaaagatgtt tacgccaggg agcagctcca 1608421 catacggcat gggattttat gttgctcccg gaagctattc aaaccatggt gttatgccgg 1608481 gcttcaatat cttgaacagc tttagcaaat ctgggcaaac cattgttatt ttgttctcaa 1608541 acattcaaaa taatgctaaa ttgggccaag tgaacaataa aatataccag cttctaaatc 1608601 aagaatgatt ggcgatcttc ttttggatga attgcattcg gcacgtgaaa agaagactgg 1608661 cctgcaaacg ttaagatggc aagcttgaca agtatttccg acacatttac aatgaagttg 1608721 taacatttgt ttttttaaca tgattgttaa accatttaaa cttgacaagg gcgatgaaca 1608781 cactcattcc ctgtgaaggt tctgtatgtt gagaaaacta gacaatgtac atgccgacac 1608841 tttttaagca acaaccaagt tcatagcaag aggaggtgaa agtatgaccc caattatgat 1608901 ggttctcatc tccattttgc tgattctact cggtttagtt gttggctact ttgttcgtaa 1608961 aaccattgcc gaagcgaaaa ttgcgggcgc acgcggtgca gccgagcaaa ttcttgaaga 1609021 tgcgaagcgt gatgctgaag cactgaaaaa agaagctctg cttgaagcaa aggatgaaat 1609081 ccacaaactt cgaatagatg ctgaacagga agttcgtgaa agacgaaatg agcttcaaaa 1609141 acaagaaaac cgtttactcc aaaaggagga aaaccttgat cgcaaacatg agggaattga 1609201 taaacgggaa gcgatgttgg agaagaaaga tcattctctg aatgaacgac aacaacatat 1609261 tgaagagatg gaaagcaaag tggatgagat gattcgtatg cagcagtctg agttggaacg 1609321 aatttcgagt ctgactcgtg acgaagcgaa acaaatcatt cttgagcggg ttgaaaacga 1609381 gctttcacat gacatcgcca tcatgacaaa agaaactgaa aaccgtgcga aagaagaggc 1609441 ggataagaaa gcgaaaaaca ttctttcact cgccttacag cgctgcgcag cggaccacgt 1609501 tgccgaaaca acggtatcag ttgtcaatct tccaaatgat gagatgaaag gacgtatcat 1609561 cggacgggaa gggcgtaaca ttcgtacgct tgaaacgctg acaggaattg acctgattat 1609621 tgatgatacg cctgaagctg tcattctttc cggatttgat ccgatcagac gtgagacagc 1609681 cagaattgct cttgataaac tcgttcagga tggccgtatt catccggcac ggattgaaga 1609741 aatggttgaa aaatctcgcc gcgaggtcga tgactatatt cgtgagatgg gtgagcaaac 1609801 gacatttgag gttggcgttc atggcctcca cccagatctc atcaagatcc tcggccgctt 1609861 aaagttccgt acaagctacg gtcaaaatgt gcttaagcat tccatggaag tcgcattctt 1609921 ggccggtcta atggcatcgg agcttggtga agacgcaaag cttgctaaac gtgcgggtct 1609981 tcttcacgac atcgggaaag caattgacca tgaagtagaa ggaagccacg ttgagatcgg 1610041 ggtagagctt gcgaccaaat ataaagagca cccagtcgtg attaacagta ttgcatcaca 1610101 ccacggggac gaggagccga cttccattat tgctgtactg gtagctgcag cagatgcgct 1610161 ttccgctgca agacctggcg caagaagtga gacgctcgag aattatattc gaagacttga 1610221 aaaacttgaa gaaatttctg agtcctacga aggtgttgaa aaatcatttg ccattcaggc 1610281 tggacgcgaa gtgcgaatta tggtgaagcc ggattcaatt aatgatcttg aggctcatcg 1610341 actggcgcga gatatccgca agcgaattga ggacgagctc gattatccag gtcatattaa 1610401 ggtgacagta atcagagaga ctcgagccgt agagtatgca aaataaagtg atgcgctaag 1610461 catcacttta tttttttgac ggcaaggaat tttcaagaag aaaggattta caaaatgaga 1610521 attttattta tcggagatgt tgtcggttca ccgggccgtg acatggtcaa agaatatgta 1610581 ccaaagctaa aaacaaaata taagcctcac tttaccatta ttaatggtga aaacgccgca 1610641 catggaaaag gcctgacgga aaaaatttat cacagcttaa tccagtccgg cgcagatgca 1610701 atcacaatgg ggaaccacac atgggacaaa aaagaaatat ttgattttat agatgacgtt 1610761 ccgaacttgg ttcgcccggc aaactttcct gaaggaacac cggggaaagg gatcacatat 1610821 gtgaaagcaa acggcaaaga actagcagtc attaatttgc agggacgtac gtttttgccg 1610881 ccgcttgatg acccgttttt aaaagcggat gaattgatcg cagaagctgc gaaaagaaca 1610941 ccgtacattt ttattgactt tcatgccgaa gcgacaagtg aaaagctcgc acttggctgg 1611001 tacacggatg gacgggcatc ggctgtagta ggaactcata cacacgtgca aacagcggat 1611061 aaccgcattt tgccgaaggg aacggcatat attactgatg tgggaatgac tggcccgtat 1611121 gacggtatac tggggatgga cagagagacg attattaagc gattcaaaac gaaccttcca 1611181 gtccggttta ctgtcgctga aggaaaaaca acgctcagcg gagttgtcat tgacattgac 1611241 gatcaaacga aaaaagccgt gaaaattgag cgtattttaa tcaacgatga tcacatgttc 1611301 tttgaatagt tgaacatatg gttattttat aaaaatatta aaaagaaaag caggaatata 1611361 gcaactcctt agtgaatata gtaaaaatgg aaggtagccc gctatttttg aaaagcattg 1611421 tggggatggc tttttggata gcaacatcta ataatgattg ttctaatgaa cactcactta 1611481 tccattgtaa aactaagggg gagcagaaat ggaaatctta aaagtttcag caaaatcgag 1611541 tccaaattca gtggcaggtg cgcttgcagg cgtgttgaga gagcgaggag ccgccgagat 1611601 tcaagcgatc ggagcgggtg cattaaacca ggctgtaaaa gctgtggcga ttgccagggg 1611661 atttgtggcg ccaagcggcg ttgatttgat ttgtattccg gcttttacag atattcaaat 1611721 cgatggggaa gaaagaacag cgattaaatt aatcgtggag cctcgctaaa aacaaataaa 1611781 gcattctcaa cctgtttgcg taatgcaaac aggttgtttt tcatttattg tgatattttc 1611841 tcccgatagt atttttagca cataaatgag cgaatataca aaatcagaaa tgagctaaaa 1611901 cgtttcaaaa aaaatttccg cccatttttc aagacagata cttttgtcct tctggaaaag 1611961 acagttctgt ttacgcttat tccatatcat ggtacaatcc gaatataaca agaatttttc 1612021 aaggaggatt gtacatgcag agtggaaaga tgaaagctct aatgaaaaag gacggggcgt 1612081 tcggtgctgt gctgactgaa gttcccattc ctgagattga taaacatgaa gtcctcataa 1612141 aagtgaaagc cgcttccata tgcggcacgg atgtccacat ttataattgg gatcaatggg 1612201 cacgtcagag aatcaaaaca ccctatgttt tcggccatga gttcagcggc atcgtagagg 1612261 gcgtgggaga gaatgtcagc agtgtaaaag tgggagagta tgtgtctgcg gaaacacaca 1612321 ttgtctgtgg tgaatgtgtc ccttgcctaa caggaaaatc tcatgtgtgt accaatactg 1612381 ctataatcgg agtggacacg gcaggctgtt ttgcggagta tgtaaaagtt ccagctgata 1612441 acatttggag aaatcccgct gatatggacc cgtcgattgc ttccattcaa gagcctttag 1612501 gaaatgcagt tcataccgta ctcgagagcc agcctgcagg aggaacgact gcagtcattg 1612561 gatgcggacc gattggtctt atggctgttg cggttgcaaa agcagcagga gcttctcagg 1612621 tgatagcgat tgataagaat gaatacaggc tgaggcttgc aaaacaaatg ggagcgactt 1612681 gtactgtttc tattgaaaaa gaagacccgc tcaaaattgt aagcgcttta acgagtggag 1612741 aaggagcaga tcttgtttgt gagatgtcgg gccatccctc agcgattgcc caaggtcttg 1612801 cgatggctgc gaatggcgga agatttcata ttctcagctt gccggaacat ccggtgacaa 1612861 ttgatttgac gaataaagtg gtatttaaag ggcttaccat ccaaggaatc acaggaagaa 1612921 aaatgttttc aacatggcgc caggtgtctc agttgatcag ttcaaacatg atcgatcttg 1612981 cacctgttat tacccatcag tttccattag aggagtttga aaaaggtttc gaactgatga 1613041 gaagcgggca gtgcggaaaa gtaattttaa ttccataaag ggggataaac atgacgaagg 1613101 aatttgagtt tttaaaagca gagcttaata gtatgaaaga aaaccataca tggcaagaca 1613161 taaaacagct tgaatctatg cagggcccat ctgtcacagt gaatcaccaa aaagtcattc 1613221 agctatcttc taataattac ctcggattca cttcacatcc tagactcatc aacgccgcac 1613281 aggaggccgt tcagcagtat ggagccggca ccggatcagt gagaacgatt gcgggtacat 1613341 ttacaatgca tcaagagctt gagaaaaagc tggcagcctt taaaaaaacg gaggcggcac 1613401 ttgtattcca atcaggcttc acaacaaacc aaggcgtact ttcaagtatt ctatcaaaag 1613461 aggacattgt catctcagat gaattgaacc atgcctctat tattgacgga attcgactga 1613521 caaaggcgga taaaaaggtg tatcagcacg tcaatatgag tgatttagag cgggtgctga 1613581 gaaagtcaat gaattatcgg atgcgtctga ttgtgacaga cggcgtattt tccatggatg 1613641 gcaacatagc tcctctgcct gatattgtag agctcgctga gaaatatgac gcatttgtga 1613701 tggtggatga cgcccatgca tccggagtac ttggcgaaaa cggcagggga acggtgaatc 1613761 acttcggtct tgacggcaga gtgcatattc aggtcggaac attaagcaag gcaatcggag 1613821 tgctcggcgg ctacgctgca ggttcaaagg tgctgatcga ttatttgcgc cataaaggcc 1613881 gtccattttt attcagcaca tctcatccgc cggcagtcac tgcagcttgt atggaagcga 1613941 ttgatgtctt gcttgaagag ccggagcata tggagcgctt gtgggagaat actgcctatt 1614001 ttaaagcaat gcttgtgaaa atgggtctga ctctcacgaa gagtgaaacg ccgattcttc 1614061 ctattttaat aggtgatgaa ggtgtggcaa agcaattttc agatcagctc ctttctcgcg 1614121 gtgtttttgc ccaaagtatc gttttcccga ctgtagcaaa gggaaaagcc agaattcgca 1614181 cgattataac agcagagcac accaaagatg aactggatca ggcgcttgat gtcatcgaaa 1614241 agacggcaaa ggagctccag ctattgtaac aagaggaaga gtttactctt cctcttttga 1614301 ttccttattg attattattc tcaatgagtg tacaatgata ggttgccagt tgtgcagagc 1614361 ttcaataacc tttatactga agggtggaag tttggtttga aaggagaaaa tatgacatga 1614421 atgaaaaaca aaaattagag agcggacaag ttcatccatc ggacaaaaaa tccgagaagg 1614481 attacagcaa gtactttgaa gctgtttaca ttccgccttc tttaaaagac gcgaaaaaac 1614541 gaggcaagga agccgttact tatcataatg actttaaaat ttctgaacaa tttaaaggat 1614601 tgggagacgg aagaaagttc tatatccgta cgtacggctg ccaaatgaat gaacacgata 1614661 cagaggttat ggcagggatc tttatggcgc tcggttacga agcgacaaac tctgttgacg 1614721 atgccaatgt cattttgtta aatacatgtg caatccgtga aaatgctgaa aacaaggtgt 1614781 ttggtgagct cgggcactta aaagcactga aaaaaaacaa tcccgatctg attttaggcg 1614841 tgtgcggctg tatgtcccaa gaggaatcag tcgtgaaccg tattttgaaa aaacatccgt 1614901 ttgtcgatat gattttcgga acgcataaca ttcatcgcct gccggagctt ttgtcagaag 1614961 catacctttc aaaagaaatg gttgtagaag tttggtctaa ggaaggggac gttattgaaa 1615021 accttccaaa agtccgaaat ggaaaaatta agggctgggt caatatcatg tacggctgtg 1615081 acaaattctg tacgtattgc attgtgcctt acacacgcgg aaaagaaaga agccgccgcc 1615141 ctgaggatat cattcaggaa gtgagaaggc tcgcaagtga aggctataag gaaattactc 1615201 tgttaggcca aaacgtaaac gcgtatggaa aagactttga agatatgacg tacggacttg 1615261 gtgatttgat ggatgaactg agaaaaatcg atatcccgag aatccgtttt acaacgagtc 1615321 atccgcgcga ctttgacgac cgcctcattg aagtgctggc aaaaggcgga aatctgcttg 1615381 atcacattca tcttccggtt caatcaggaa gctcagaagt tctcaagctg atggcccgca 1615441 aatatgacag agagcgttac atggagctgg tgcgaaaaat taaagaagca atgccaaacg 1615501 cttctttgac aacggacatt atcgtcggat ttccaaatga aacggacgaa cagtttgaag 1615561 aaacgctttc tctataccgt gaagtggagt ttgacagcgc ctatacgttc atttactctc 1615621 cgcgtgaagg cactccggct gctaagatga aagataatgt accgatgcgt gtgaaaaaag 1615681 aacgcctgca gcgtctaaac gcactggtga atgaaatttc tgctaaaaaa atgaaggaat 1615741 acgaaggcaa ggttgtcgaa gtattagttg agggtgaaag caaaaataac cctgatattc 1615801 ttgctggcta tactgaaaaa agcaagcttg tcaatttcaa agggccgaag gaagccatcg 1615861 gcaaaatcgt ccgcgtgaaa atccagcaag cgaaaacatg gtcgcttgac ggagaaatgg 1615921 taggagaagc aatcgaggtg aaatgagatg acgctctact caaaaaaaga cattgtgcag 1615981 caggctcgaa accttgcaaa aatgatttct gaaacagaag aggttgattt tttcaaacgg 1616041 gctgaagcgc aaatcaatga gaatgacaaa gtgtccacaa tcgttaatca gattaaagcc 1616101 ctgcaaaagc aggctgtcaa tctgaagcat tatgaaaagc atgaagcgct caaacaagta 1616161 gaagcaaaaa ttgacgcgct gcaagaagag cttgaagaga ttcctgttat ccaggaattc 1616221 agagactcgc aaatggaagt aaatgaccta ctgcagctcg ttgcacacac catttccaac 1616281 caagtcacaa atgaaatcat cacatcaacc ggaggcgacc tgctgaaagg ggaaaccggt 1616341 tcaaaggtga agcattcaaa taacagctgt tctctctaaa cacggtgcct ttacaggccc 1616401 gtgttttttt atcatttgtg cggttaaaaa tgaactaaat aatctatgta ccaaatgttc 1616461 aattggtttt tctgtgctca gccgcgtata aactttatcg cacttataag taaagtttct 1616521 aggcacccct gcatacaatg gaacagaaac tttgtatttt tatattttat ttataaaaat 1616581 gcacactaga caaatgccca gcataagata acacgaagaa gaacaaggag gcatgccgga 1616641 atgtctgaat acagggaaat tattacgaag gcagtagtag cgaaaggccg aaaattcacc 1616701 caatgcacca acaccatctc gcctgagaaa aaaccgagca gcattttggg tggttggatt 1616761 attaaccaca agtatgacgc tgaaaaaatt ggaaaaacgg tagaaattga agggtattat 1616821 gatataaacg tatggtactc ttacgcggac aacacaaaga cagaggttgt cacagaacgg 1616881 gtaaaatatg tagatgtcat taaactcaga tacagagaca ataattactt agatgatgag 1616941 catgaagtga ttgccaaagt gcttcagcag ccaaactgcc ttgaagtgac catttcgccg 1617001 aatggaaata aaatcgttgt gcaggcagaa agagaatttt tggcggaagt ggtaggggaa 1617061 acaaaggtag ttgttgaggt caatcctgac tgggaagagg atgacgagga agattgggaa 1617121 gatgagcttg atgaagagct tgaagacatc aacccggagt ttttagtggg agatcctgaa 1617181 gaataaaaaa gggactaggg gagacagtac ccccaagtct cttttttata ttgatatatc 1617241 attcttttat cactttttgt ttatgttata atgaaggttg gaaaatagaa acgttgatac 1617301 atagtgaggg attaaacaat ggccggttat acgcctatga tacagcaata tttaaaaata 1617361 aaggcagagc accaggatgc ctttttattt tttcgcctgg gtgattttta tgaaatgttt 1617421 tttgaggacg ccaaaaaagc gtcacaagag ctggaaatta cgttaacgag cagagacggc 1617481 ggtgcggctg aaaaaatacc gatgtgcggt gtgccgtatc attctgcttc cgcgtatatc 1617541 gaacagctta ttaaaaaagg atacaaagtg gcgatctgtg aacagacgga agatccgaaa 1617601 gccgcaaagg gcgttgtgaa aagagaagta gttcagctga ttacgcccgg aactgtaatg 1617661 gacggcaaag gcatccatga gtcggaaaat aattttatcg catctgtttc agcctgctcg 1617721 aacggatacg gacttgctct gtctgattta acaacgggag aaaatttggc tgttttgatt 1617781 gaacggcttg aagacgtcat atcagaaatt tattcagtcg gcgcacggga aatcgtggtt 1617841 tcaggaagct tggatgccga tacagtggca cagctgagag agcggtgcgg tgcaacgatt 1617901 tcaattgaag acggagaaac agacgaacac gtaacgatca ttgagcactt aaataatgaa 1617961 gatataacaa aaacatttct gcgcttatat acgtatttga aaagaaccca aaagcgcagc 1618021 cttgatcatc ttcagcccgt gcaggtgtat gagcttgagg aagcgatgaa aattgacttg 1618081 tactcaaagc gtaatctgga gctgaccgaa acgattcgtt cgaaaaataa aaaaggctcc 1618141 cttttgtggc tgctggatga aacaaaaacg gcaatgggag gccggctact taaacagtgg 1618201 attgaccggc cgcttatcag agtcaatcaa atcgaagagc gccaagaaat ggtggaaaca 1618261 ttaatgtccc atttctttga acgggaagat ctgcgtgaac gtttaaaaga agtatatgac 1618321 ttagaacgcc ttgccggccg cgttgcattc ggaaatgtca atgcccggga tttgattcag 1618381 ctgaaggaat cgttaaagca agtgcctggc atcaaacagc tggttgcttc actggctcat 1618441 gacaaggcca aggaacgtgc aaagcgcatt gacccttgcg gggatgtact tgaactgctg 1618501 gaagaagcgc tgtacgaaaa ccctccttta tcggtaaaag aagggaacct gattaaagat 1618561 ggttataatc aaaagcttga tgaatatcgt gatgcaagca gaaacggaaa agactggatt 1618621 gcccgcctgg aacagcagga gcgggaatac acaggcattc gctctttaaa ggtcggcttt 1618681 aataaagttt tcggttatta cattgaagtg acaaaagcaa acttgcattt gcttgaggaa 1618741 gggcgttatg agcggaagca gacgttaacc aatgcagagc gctacattac acctgaatta 1618801 aaagaaaaag aagcgctcat tttagaggcg gaaaataaca tctgtgagct ggagtacgag 1618861 ctgtttaccg agctgcgcga gaaagtgaag cagtatattc cgcggctgca gcagcttgca 1618921 aaacagatga gcgagctgga cgcactgcaa tgctttgcga caatcagtga aaatcgccac 1618981 tacacgaaac cagagttctc taaagatgaa gtcgaagtga ttgaaggcag acacccggtt 1619041 gttgaaaaag tcatggacag ccaggaatat gtcccgaaca actgtatgat gggcgataac 1619101 agacaaatgc ttctcattac aggtccaaac atgtcaggga aaagcacgta tatgagacaa 1619161 atcgcgctca tttccattat ggcgcaaatc ggctgctttg tacccgcgaa aaaagcggtg 1619221 ctcccgattt tcgatcaaat ttttacgcga atcggcgctg cagatgattt gatttccgga 1619281 caaagtacat ttatggtaga aatgcttgaa gcgaaaaatg cgattgtcaa tgcgacgaaa 1619341 aacagcctca ttctgtttga tgaaatcggg cggggaacgt ccacttatga cggcatggcg 1619401 ctggcacagg cgattattga atatgttcac gatcatatcg gcgccaagac gctgttcagc 1619461 acacactatc acgagctgac cgttcttgag gacaagctgc cccagctgaa aaacgttcat 1619521 gttcgcgctg aagaatataa cggaacggtt gtctttcttc atcaaattaa agaaggtgcg 1619581 gctgataaaa gctatggtat ccatgtagct cagcttgccg aactgccggg agatctgatt 1619641 gcgcgcgctc aagatatttt aaaagagctt gagcattcag gaaacaaacc ggaagtgccg 1619701 gtgcagaaac ctcaggtgaa agaagagccg gcacagctgt ccttttttga cgaagcggaa 1619761 aagccggctg aaacaccaaa gctttcaaaa aaagaaaagc aagtgatcga tgctttcaaa 1619821 tcacttaata tactggatat gacaccgctt gaagcgatga atgaaatgta caagctgcaa 1619881 aagaaattac attaaaacgg ggtgatgaat gtggcaaaag tcatccaact gtcagatgag 1619941 ctttcaaata aaatagcggc gggcgaggtt gtggaacggc ccgcctcagt cgtcaaagaa 1620001 ttggtggaaa atgcgatcga cgctgacagc acagtcattg aaatcgatat tgaggaagca 1620061 ggccttgcat ccattcgggt cttggataac ggcgaaggaa tggagaatga agattgcaag 1620121 cgagctttcc ggcgccacgc aacgagtaaa ataaaagatg aaaatgattt attcagggtg 1620181 agaacgctcg gtttcagggg agaagccctg ccgagtatcg cgtcagtctc tcatctggag 1620241 attacaacaa gcactggtga aggagctggg acgaagctcg tcctccaagg aggaaacatc 1620301 atttccgaat cgcgttcctc aagcaggaag ggaactgaaa ttgtcgtttc caacctgttt 1620361 tttaacacac cggcccgttt gaaatatatg aaaaccgttc atacagagct tggaaacatt 1620421 acagatgtgg ttaaccgtat tgctctggcg catccagagg tatcgatccg cctgcgccat 1620481 catgggaaaa acctgcttca aacgaacgga aacggagatg tgcgccatgt actggcagcg 1620541 atttacggca cggctgtcgc caaaaaaatg cttccgctgc atgtgagctc cttggatttt 1620601 gaagtaaagg gatatatcgc cctcccagag attacacggg cgtcgagaaa ctatatgtcg 1620661 tctgtggtca atggccgtta cattaaaaat ttcccgctcg tcaaagcggt tcatgaaggc 1620721 tatcatacgc ttctgccgat cggacgccat ccgattactt ttatagaaat tacgatggac 1620781 ccgattttag tcgatgtcaa cgtgcatcca tcgaagcttg aggtccggct cagcaaggaa 1620841 acagagcttc atgacttaat acgtgacgga attaaagatg tgtttaaaca gcagcagctg 1620901 attcctagtg cccaggtccc gaaaaaatca gcacctgcca tcaaaaatga gcagcagttt 1620961 ataacctttg atgaaaagcc tccggaaaaa aaagttccgg aaaaatcgac tgcgccatct 1621021 tattcaccga tgaagctcag ctcagtcgta aaagagccgg ttgatgcgga ggaaaaattg 1621081 ccccctctcc aatttgatgc tcctcctatc gttgatcagg aacaaaccct tgaggtgtcc 1621141 gatgtttcag cagaacagcc tgaaacattt gagcaggaat gccatgagga acagccgcag 1621201 ccagcgtctg atcgggttcc aattatgtac ccgattggcc agatgcacgg gacttatata 1621261 ttggcacaaa acgaaaacgg cctatatatt atcgaccagc acgccgccca agaacgtatt 1621321 aaatatgagt acttccgtga aaaggtgggg gaggttgagc ctgaggtgca ggagatgatt 1621381 gtaccgctga cgttccacta ctccacaaat gaggctttga ttattgaaca gcacaaacaa 1621441 gagctcgaaa gcgtcggtgt ctttttagag tcattcggct ctaacagtta catcgtccgc 1621501 tgccacccag cctggtttcc aaagggagaa gaagcagagc ttatagaaga aatcattcag 1621561 caggtgctcg actccaaaaa tatagatatt aaaaaacttc gcgaggaagc ggcgattatg 1621621 atgagctgca aaggctccat caaagcaaat cgccacctca gaaacgacga aatcaaagcg 1621681 cttctggacg acctccgaag cacatcagac ccatttacat gcccgcacgg ccgcccgatc 1621741 atcattcacc actcgacata tgagatggaa aagatgttca aacgcgtgat gtagcggggg 1621801 tggtaggcat tgatccattc tctgaatgga tcaatgcttt ttttgtactc cttcgagtgt 1621861 cagattataa gaaacggttg taaacgtgtg agcagtgtta acgcattata cttcatggtt 1621921 cctccgtata acaaaatttc catttacagg caattgggat taatgtatat tttgggtgag 1621981 ggggtggaaa catatggcat gtggtccgaa gatcattatc tttttggatg aacttgatga 1622041 tccaaatgtg agaatcattt tagaatgcag aatttaaatt acaacattgt gttttgctcc 1622101 ctgttcgtgt gaacagggag attttttcgt ttatataact ggtgatgtcc aaatataggg 1622161 tgttatgaat tttccatatc tgccatcggc tttaagctgc ttctctatta ggctggttat 1622221 caaaagcaag ttcaatgata gccatgaaag ctgatatcac aacaagcaag acatctggaa 1622281 tataaataga ctgcataaag taatctgcaa aacagatcgt tataagattg ctgataaaat 1622341 acagtataaa agcaaaaagt gcagtctttt tcaatgaaag tgattttgcc aaaatgatag 1622401 agataatctt tgtgagtggg tctatgatta aacctacagc aaagcaggct aaaataaata 1622461 aagctaatgt ttgattggaa gcgtatgtga tgccaagtat ggagaataag cctttcatcc 1622521 cgaagaaaaa gccgccgaag atgactgcaa gcgcgatggc cgcgataaaa gtaatagata 1622581 caattccgat taattttgat ctcaggttaa aatctttaga gtgctcgttc tgttcttttt 1622641 ggttcatgta tgacactccc ttcacctgct tactcataca aacagcaccc ttgaatcagc 1622701 ccaaaatatc tataagtctg ttttctgacg aaaatagtat agcatatttt aacaaaacca 1622761 aaaaaggccc tttccactgg ggaagggcct ttttcatcat gttaactcct gagattcgcc 1622821 gaagctttct ctttttttgg ccaaataaaa tagctggctg taatgagaaa gtcaatgcct 1622881 ataatgacag tccacagttt aagaatgccg ctcaacgcct cggttcggga agagtcattg 1622941 ataaaataga tcatccctgc caatagtccc gcaccaatta agtaggccag cacatgtctt 1623001 agccagcctt tcgcaccgtg cttggcatgg tccattccaa aacgtttcag cggttttgtt 1623061 cctttttttg tcacataata ttgaaacttt tcatctgccc attgaatcat ttgtttccca 1623121 taagcgatcg atataccgat gtaaacagct gcaatcccat gggctgcggt cgctgaggct 1623181 ccgcggtaaa ggtccacacc agttgccgct aacaagatca aatcgataac tggagttaag 1623241 gcaaggaata gcagtcctaa tgtatgtcgt ttgaatacgt agcgtacagc aagccccaaa 1623301 acaatgacaa cccaaaacgc aatttcacag aaaacaatca tccatgcgat accgttcaat 1623361 ccattcccct cttttcaata cagttgtatt atttaaataa tatgttacca tctttgtttt 1623421 tgtaacacaa ctgtattata aaaattgccc cgcctttgaa cgaaagctca aaggcgctac 1623481 gctgtattat tttgatgaaa gtggctgtca gctgtgctgg atatcaattg tatatactgc 1623541 acgatctgtt acgaccttca atccttcgtt ttcttggtga atatgaagct cacctaataa 1623601 aggaatctca taggcatttt gcggaagcgg tacgtttccg tcctcagtga atgttgttcc 1623661 ttcgccttct aaaacaagct cttctttcgc aacataatca tcaggatgat tcgtactgcg 1623721 tatagccact ttttgaaggt ggagaacaat ctgatccaag tctgatatct cttcatcatg 1623781 ggtcaattca ccttttctaa tatcaagcgt ctggccgact tttgattcca gccattgaga 1623841 aagctgtgta ttcgtgtgtg ccatcaatat tcctcctttt gatctacacg atactattcc 1623901 caattgctgc atcttttaca cgggaaagag ccgccccact ctttatgtat gaaacagttc 1623961 gctgttgagt gccttgatat agcgtacggc agaacgctgg accgattcgt cggcattttc 1624021 tttgacaact ttagagaaag cattgtaaag ccggttgaat tgaagcggtt ttactttggc 1624081 tgctatttct tcaactttgg aggcgggaag gggaatgaga tttgggtagc tgtacataaa 1624141 gctgacccag tttcgatccg ccgcaaccgt aatgatatct ccggtcaata gacagccttt 1624201 cccttcattg cccttgctcc aatgcaaaac agcaccgcct ttaaaatgtc cgcccagtcg 1624261 gtaaaggtcc agtcccggct tcatattgag cgtttcccct gaccagaagt gaatgtgatt 1624321 gcttggcctt gtcacccatt ctttatcatc ctcatggata tagatcggcg cctgaaacgc 1624381 ttcagcccac tcaacctgag tagagtaata atgtggatga gacaaggcga tggcttgaat 1624441 accgcctaat tcgttgattt ggtcaattgt cttttggtca agatatgtca tgcaatccca 1624501 cagcacattg aagcccttat gctgaataag atgggctgtt tgtccaatcg caaactctgg 1624561 ttcagttttg atgctgtaaa gatgctcttc ttccttttta aggatgtttt gaaggtttcc 1624621 tttctcacgc atgtcttcaa gggttgtcca agtttgtcca tcgggatgaa tatactgtct 1624681 ttcatcctcg caaatcagac acgagttggg cggatctaca gtctgtgcat gttgcacacc 1624741 gcatgtattg cagatataat atggcacttt cttcacttcc ttcatctatt ttccattatt 1624801 ttaccttatg attatgaata ttcaaacgaa aaaaccggca gttctgctga gagagaattg 1624861 ccggcttttg atgatgttta ttggccggga acggaatttt ctgcgttgac agcgcccgct 1624921 ccgtagatat tcggatcttc atctttccat ttgtccgtgc cgtttttcaa aagctctttt 1624981 acttcatcag gggtaagatc cgggttttgc tgaagaatta aagctgcgat tcctgcgcaa 1625041 atcggtgttg ccatcgaggt tcctgacatt gtaaagtact gagaccctac acggcttgac 1625101 ttttggagct tatcaatata agaattcgga gagcgaaggg aaataatatt aacacccggc 1625161 gctaaaatat cgggcttttc tttcccgtat actgtcgggc cgcggcttga gaaggaagcg 1625221 acagtatcat catcgctgct tgcagtattg ttatcgtcaa gcgcacctac tgtaatcacc 1625281 ttttcgctca cgcccgggct tgcaatggtc tgcgaatcag ggcctgagtt tccggcagcg 1625341 acacagacga caatccctgc gctccacgct tcctcaaccg ctctgactaa cggatcttcc 1625401 tgttcatgat catatctaag ggcatcgccc ccgagcgaca tgctcataat atcaatcggt 1625461 tcatcggggt tgtcctcatt gtattgaata caccactcaa caccctctat aatatctgct 1625521 aacgttcctg aaccctgctt gtttaatacc tttacgccga tgagattggc ttccggtgca 1625581 ggtccgcggt attgaccgga agaggatgca ccgctgcttg cgacatcacc tgcacagtgt 1625641 gtgccatgac cattatcatc gtacggctct gttttttgat tgaccatgtc cgcgaatccg 1625701 ataattcttc cttctagatc aggatgcggg tagattcctg tatcgacaac agcgacagta 1625761 acaccttttc ctgtcagggt ttgcccgttt ctgacgactt ccttcgcatg gcttgcttcg 1625821 gttgccgtgt ctaaaagcgc tttgacttcg cggtttaaat acactttacg gatattgctg 1625881 cattcagaga gaagggaatg taatgctgaa ggagtaacct cggcgctgca gcagttgatt 1625941 ttgttgaagc ggctttttag cttgctgcgt ttttcttttt gcagcacctc tccagccatt 1626001 tgaaagccgg tctcgtgaca gccttcctca aattcgataa tgactgacat tttttttctg 1626061 ttttgcaatt tggtttcgaa aaatttatgc aagaagcaag gagtccattt gaagggcttg 1626121 taaagttgca atacggtttc ccgtaacggc caatctagct tgtgagcatt tgctctcacc 1626181 atttgtacca tagagtaccc aaacatgtat tttcctccta ttataaggtt ctctgtatac 1626241 tctatgaaca gatgataggt ttggtaagtt tgtttgtcct ctgtaagaga cagacaagag 1626301 tttgtttttc tgaatctttc gcattagata cgatagattc agaagctgag gaaatcattg 1626361 gggattgaaa aagaacgttt gttcgtatta taatgtgatc atatcaaact gggaagggga 1626421 gagcaaccgt atgaatttct acttgcaccg atctttggaa agccaaatgc caatcagcat 1626481 tatatatgaa gaaagacgga acgattagta aaagaacgat tattgtgaga cagaaaagca 1626541 aaacgaaaat caaagcattt tgtttttcga aacaacagat cagaacattt ttattggact 1626601 ctatcctctc ctgtgatttt gtgagaacaa ataagcaaaa tctctattct gcaggccggt 1626661 aacagctgtc cgtctcagca accgggcagc ctgttactaa aaccctcctt aaacctatat 1626721 acatttattt gccaagtgag gttgttccta ccttttttgt ctttcctctc aacctttttt 1626781 cactcttatt tgaaatgaac cgctaataac cgtgacaatc aattgatttt ttgaaaccgg 1626841 gaactttttc actgatgata ttgtgtatac aatggtaaga taaaacctat tggctaaacc 1626901 tcatataatg aaccgcgcca ttcttatgaa aggagttaaa catgagaaga tttttactaa 1626961 atgtcatatt agtcttagcc attgtcttgt tcttgagata tgttcattac tcattggaac 1627021 cagaaccatc aaatcagcca gatacatatt caaatttcag cagcttggca gagaatgaga 1627081 gcccagccga ttacgatatt tcatataatg agaaaaaagg aagcaaagtc ttaattatgt 1627141 ctccgcatgg cggaagaatt gaaggcggag taagtgagct tgtgcgttat ttcaataatg 1627201 aatactctac atacctattt gaagggttga agtcccatga taaccaaaca ctgcacatta 1627261 caagcaccaa ctttgatgag ccattggcaa aaaagaaaat caaggagcat caatatgtgg 1627321 tggcttttca cggatataaa ggagagaaca agaataccct tgtaggggga acagaccgaa 1627381 agcgggcgaa aatgattgtg agagcccttg agcggagagg gttttccgct gagttagcgt 1627441 cgtctaaaag cggtcttgct ggattgaatg ccgaaaacat taataaccaa ggggaaacgg 1627501 ggctaagtat ccagctggaa atcagccgtg agcagagaga agcatttttt gatgattttt 1627561 attataaaaa tagaaaatac acaaagaaca gtgaatttta tgcttatgtc agtgcgatca 1627621 aaggtgtcct ggaaaaagag tattcgtaac aagcagatca gaagacaaaa taagagaaga 1627681 tcagtagact gaaataggat aaaaaaggag gcaaaacaat ggcagatcat catttttatt 1627741 taaaagcgaa ctggccgggt aaccgtaatg atgtcggtac gatcgaaagc ggaaacctga 1627801 tcacatcgat ttccattcct aaagaaatgg atggcccggg agaagggacc aacccagatg 1627861 aaatgcttct cggggcggca gcgacctgtt acattattac acttgcagcg atgatggaga 1627921 gaagcgggct ggaaaaagaa gacttacaga tggagtcaga aggcattgtc aacgttacaa 1627981 aaggagtctt tacatacaaa aagatcattc accgtccctc tgtcgtgctt aaacatgatg 1628041 cttcacaaga cgacgtcgca ttggcgcaca aactttgtaa aaaagcggag tcgtcatgca 1628101 tgatttcgcg tgcaattcaa ggaaatgtcg agctgcagct tgaagcctct gtgaaactgg 1628161 gtggagaata aagaaaacag acggtcactc acaggccgtc tgttttttat cttcagcgtg 1628221 ggctttcgat tgatttagca cgaccacgcc tgcaatgaca agcgtgagac cgaatacacc 1628281 ttttaaactg atggtttcgc caaaaagcaa aaacccgaca attgctgtaa gcgcggtacc 1628341 aacgcccgac catgttgcat acgcgcttga taagtcaatt gtttttaaag aaaagcttag 1628401 aaacgtaaaa gcagaaagaa atccgactat gactccggca atgggccagg cttgtgtaaa 1628461 tccttctgaa agcttcaaca tcgtgctccc aaacacttca gatacaatgg cgagagccaa 1628521 ataaagcaat cctctcatct tcatcactcc tttacggcca attaagtaac acgacccctg 1628581 atagtaataa aagaatcccg ataagccctt tggcattcag atcttccttg aaccatttta 1628641 ctccgatcac tgtcgtcagc accgtgcctg ccccgctcca agtcgcatag gagaggctca 1628701 ggggaatatg gtttaaagtc agggacagca tataaaaggc gagggaatag ccaataacga 1628761 ccaaagcact tggcttccac tttttgaagc catcagatac tttcagcatg gctgctccta 1628821 tcgattccga acatatggca atcgtgagga atatatatcc tatcaacatc atgaattctc 1628881 ctcactatat ttttagatta gaaaaaaaac ttcagctaga aaaatattag tgtatgccta 1628941 tgtatgagtc aagagattca ttttcacaca cttaaaaaga ccccttttta aggggtcttt 1629001 tgcgtttaat aataaaaagg gaacggggca tacggataat aggggtatcc gccatacaaa 1629061 taaggattaa ataaagcgct tcctataagc ccgcctgcaa ggccgccgat aaacggtcct 1629121 ccaaaaaatc cgaatggccg gccaaaccca taaccaaatc cgggtcttcc aaacccgtaa 1629181 ccgaacccga acggtcttcc aaacccaaat ggtctcccga atccgaacgg ccttccaaat 1629241 attcttgtat cttcagggct gaaatgctct aactcgttca tgttttcttt cctcctgtaa 1629301 taaagtgtag atgatgcagt gtattcaccc tgcccggatt tgattgggcg aatcgaggaa 1629361 aaggaggatg tgaacacatt gggcctgtat cagtctgact ggtcaaaagc accgccccac 1629421 gcacatgctt atcatgtcaa aacaacgaga gaacagggcc attatcatct catcgaaggg 1629481 tttactcagc cggcaaacgg atcaaatacc gatcagcata cacattacta tacagggatc 1629541 acttcatttg aaaacggcca ttttcatcgg tattacggaa tctcaggacc ggcgattccc 1629601 ttagcagatg gcacacatta tcatgaaatc gaagaaacga cgtatctggc ctataacgag 1629661 ccgattgaga tccagtacgg aggggttgtg tacgatcccg gagatgacag aagaaaaacg 1629721 catcgtcata ccctgaaagg aaagacaagg gaaattgtcg gcaatgagcc gctcggctgg 1629781 tagaaggatg tttaccgatg caaaaaaagg gcaaaatgga taggtggttg tccatgttga 1629841 atgctataat ggggggagat ttataaaaga gagtgataca tattgaataa tacgaagcag 1629901 cccgttgtca ttttagtcgg accgacggca gtggggaaaa ccaatttaag tattcagcta 1629961 gccaaatcct taaacgcgga aattatcagc ggagattcga tgcagattta taaagggatg 1630021 gatattggaa cagctaaaat taccgaacag gagatggagg gagtgcccca tcatctgatt 1630081 gacattttag atccccaaga ctctttctct actgccgatt atcaaagctt agtaagaaat 1630141 aaaatcagcg agattgcaaa tagaggaaag cttccgatga ttgtcggcgg tacagggctt 1630201 tatatacaat ctgtgcttta cgattataca tttacggaag aggcaaatga tcccgtgttt 1630261 cgagagagca tgcaaatggc tgctgagcgg gaaggcgctg actttcttca tgccaaactt 1630321 gctgcagcag atcccgaggc agcagctgcg attcatccga ataatacaag aagagtcatt 1630381 cgcgcactgg aaattttaca tacgtccgga aaaacgatgt cccagcattt gaaggaacaa 1630441 aaacgagaac ttctgtacaa tgcagtgtta attggcctga caatggatag agacacgctt 1630501 tacgaaagaa ttaatcagcg ggtcgatttg atgatgcagt caggccttct tccggaagtg 1630561 aaacgcttat acgacaagaa cgtgagagac tgtcaatcaa tacaggcgat aggctataaa 1630621 gagctgtatg catattttga cggttttgtg acactttccg atgctgtcga acagctaaag 1630681 cagaactcga ggcggtatgc gaaacgccag ctgacgtggt ttcgcaacaa aatgcaggtc 1630741 acatggttcg atatgacacc gcctgttgat atggagctga aaaaaaagga aattttcaca 1630801 catatagcag gaaaactcga actttaatcg aaactgtatg atatagagaa tcaaggagga 1630861 cgaaacatga aaccgattaa tattcaggat cagtttttga atcaaatccg gaaagaaaat 1630921 acgtatgtca ctgttttttt gctgaacggc tttcagttgc ggggccaggt gaaaggcttt 1630981 gataacttta ccgtattgtt ggaatcggaa ggtaagcagc agcttatata taaacatgcg 1631041 atctcaacgt ttgcgccgca aaaaaacgtc cagcttgaac tcgaatagat caaaaaatgc 1631101 catgtcaaga catgaggaaa ggctgtcggg ggttcccggc ggccattttt aacatgaatc 1631161 cacttttgct ccaagctttt tgtgtaagct gaccatgcca aggcacggtc tttttttatg 1631221 agaacaacat acggaagtaa aaatggtata ttatgtataa aatgaatttg ggagtgatcg 1631281 atcttgtttg aaagtgaagc agaactgaga cgaatcagga ttgcacttgt atggatagct 1631341 gtctttttac tgttcggggc gtgcgggaat caagatacca ttattgaaac agacaacggc 1631401 aattcagact atgaaacgcc tcagcccacc tcgtttccac ttgaacataa ccattttggc 1631461 gttatggagg acggctatat caaaatttat gagtataatg agtcccgcaa tgaggtaaag 1631521 ctgaagaaag aatacgcgga tgatgagctt gaataaaatt cacaagcatt cgaatttaca 1631581 aagcggatgc cagccgctaa actaaataca gacacagatc aaacagaggg tgaaaacatg 1631641 aagcataaag tgatcgtgaa tcattgggaa gaaatttgcg aagatgattc ttgctatgaa 1631701 tacggaacaa gtatcattgt gaacggaaaa gaattaatca gagaagcgtc aattatcact 1631761 gctttgaagg cggttttaga agagatcggc gcggatgttg aaatagaaga aacagtagag 1631821 agcgaaaaat gctgtgatag cttaagaaaa aaaaatctag actactaagc agtttttttt 1631881 catgttatga tatacatcgg ctaaaaacga caccccgagt aggacgagag atgattctcg 1631941 ttctgctctc ttttttgggc cctaatgagt ctgcccgttt gcctgatttg atcaaaatat 1632001 gaatttttca taaaaacgaa tctatatatt gtgtttttgc tagagggtag tatactatat 1632061 atagtgttag tgatgagaga ttcatatttt ttgataggtc gtgataaaac gtggtacaaa 1632121 tcatatttga ttcgaaaaca gggaatgttc agcggtttgt gaataaaaca ggctttcagc 1632181 agatacgcaa ggtggacgaa atggaccacg tggacactcc gtttgttttg gtcacctaca 1632241 cgacaaactt cggccaggta ccggcatcaa cacaatcatt tctcgaaaaa tacgcccatc 1632301 tcttattggg agtcgctgcg agcggcaaca aagtatgggg cgataacttt gcaaaaagcg 1632361 ccgataccat ttcaagacaa tatcaggtgc cgatcttgca caaatttgaa ctcagcggca 1632421 catctaaaga cgttgaattg tttactcagg aggtagaaag agttgtcaca aaatcaagtg 1632481 ccaaaatgga tccagttaaa taacgaaatc atgatccaaa aagatgggaa attccagttt 1632541 gataaggata aagaagctgt acatagctat tttgtagatt atatcaatca aaacacagtc 1632601 ttctttcaca atttaaaaga gaagctggat tatttggttg aaaaccaata ctacgaagag 1632661 gaattcttaa gcctttattc ttttgaagac attaaagaag tgtttaagac agcttacgct 1632721 aagaagtttc gttttccttc cttcatgagt gcgtttaaat tctataatga ctatgctttg 1632781 aaaacgaatg acaagaaaaa aatcctcgag cgttatgagg accggatctc aattgttgcg 1632841 ctgttcttcg ctaacggcga cactgagaaa gcaaaagaat atgtaaacct gatgatcaat 1632901 caagaatatc agccgagcac accgacattt ttgaatgccg gcagaaaacg ccgcggtgaa 1632961 cttgtgagct gcttcttgct cgaagttaat gattctttaa atgacatttc aagagcaatc 1633021 gatatctcca tgcagctttc taagcttggt ggcggggttt ctcttaacct gtccaagctt 1633081 cgcgcgaaag gtgaagccat taaagatgtt gagaatgcga caaaaggcgt tgtaggcgtc 1633141 atgaagcttc ttgataacgc gttccgttac gctgaccaaa tgggacaaag acaaggctcc 1633201 ggcgcggcgt atttaaacat tttccaccgc gatatcaatg attttcttga tacgaaaaag 1633261 atttctgcgg atgaagatgt gcgtgtcaaa acgctttcga tcggtgttgt cattccggat 1633321 aagttcgttg agcttgcacg cgaggacaaa gcggcttatg tattctaccc gcacacgatt 1633381 tataaagagt acggccagca catggatgag atggacatga acgaaatgta cgacaagttt 1633441 gtcgacaacc ctcgggtgaa aaaggaaaaa atcaacccgc ggaaactgct tgaaaaattg 1633501 gcgatgcttc gttctgaatc aggctatcca tacatcatgt tccaagataa cgtcaataaa 1633561 gtgcatgcga ataaccatat ttccaaggtc aaattttcta acctttgctc tgaagtgctg 1633621 caggcatctc aagtttcttc atacacagac tatgatgaag aagatgaaat cggtctggat 1633681 atttcctgca acctgggttc gcttaacatt ctcaatgtca tggagcataa atcaatcgaa 1633741 aagacagtca agcttgcgac agactcttta acacacgtgt ctgaaacaac agacatccgt 1633801 aatgcgcctg ctgtaagacg ggcaaacaaa gcgatgaaat caatcggcct cggtgctatg 1633861 aaccttcacg gctaccttgc gcaaaacggc attgcgtatg aaagtccgga agcgcgtgac 1633921 tttgcaaaca cgttctttat gatggtgaat ttctactcca tccagcgttc tgcggaaatc 1633981 gcaaaagaga agggcgaaac gtttgatcaa tatgaaggat caacctatgc gacaggtgaa 1634041 tacttcgaca aatacgtttc aactgatttc tcaccgaaat acgaaaaaat cgctaatctg 1634101 tttgaaggta tgcatatccc gacgacagag gactggaaaa agctaaaagc atttgtcgct 1634161 gaacacggta tgtatcacag ctacagatta tgcattgcgc cgacaggctc tatctcatac 1634221 gttcaatcaa gcacggcgtc tgttatgccg attatggaac ggattgaaga acgaacatac 1634281 ggcaactcaa aaacgtacta cccaatgcct gggcttgcat ctaataactg gttcttctat 1634341 aaagaagcct acgatatgga catgttcaag gttgtggata tgatcgccac tatccagcag 1634401 cacattgatc agggaatcag ctttacattg ttcttaaaag acacaatgac gacccgagat 1634461 ttaaaccgaa tcgatctgta tgcacatcat agaggaatta aaaccattta ctatgcaaga 1634521 acgaaagata ctgggcaaga cagctgcctt tcttgtgttg tttgattaaa ggagagttta 1634581 tagtgacaaa aatttatgac gcagcaaact ggtcaaagca tgaagacgat tttacccaaa 1634641 tgttctataa ccaaaacgtg aaacagttct ggcttccgga agagattgct ttaaacggcg 1634701 atctcctcac atggaagtac ctcggaaaaa atgagcagga cacttatatg aaggtactgg 1634761 ccggacttac gcttcttgac acagagcagg ggaatacggg gatgccgatc gtggctgaac 1634821 acgtagatgg ccaccagcgg aaagcggtgc tgaactttat ggcgatgatg gagaacgctg 1634881 tccatgcgaa gtcgtactct aatattttca tgacccttgc accgactgaa acgatcaatg 1634941 aagtatttga atgggttaaa caaaataaat atttgcagaa aaaagcgcaa atgattgtcg 1635001 ggctttacaa agccattcaa aaagatgatg aaatttcact gttcaaagcc atggttgctt 1635061 ccgtctatct ggaaagcttc cttttctaca gcggtttcta ttatccgtta tatttctacg 1635121 gacaaggaaa actgatgcaa agcggtgaga tcattaacct gatccttcgt gacgaagcga 1635181 ttcacggcgt gtatgtcggt ctccttgctc aggaaattta taataaacag acagaagaga 1635241 aaaaagcaga gcttcgtgaa tttgcgatcg acctcctgaa tcagttatat gaaaatgagc 1635301 ttgagtatac agaggacttg tacgatcaag tcgggctctc acatgatgta aagaaattca 1635361 tccgctataa tgcgaataaa gcgctgatga accttggatt tgatccatac ttcgaagagg 1635421 aagacattaa tccgatcgtt ttaaacggat taaacacaaa aacaaaatcg catgacttct 1635481 tctctatgaa ggggaatggc tataaaaaag cgacagttga gccgctcaaa gatgatgact 1635541 tttattttga agatgaaaaa gagcagatat aatatctgct cttttcggct tgaaggttca 1635601 aatgaggagg acgcagtacc catgggaaaa atggacgaaa tgattttagt tgccccgcgc 1635661 gatgatgtgt ttaaaaaaga aagcttaacc ttccagggcg tgtacagtga agatagcaga 1635721 gtagcagaaa tcatggctca gattgaagcg gcctatcgtg aaatgagaag aggggacgca 1635781 gaagaagatc cgcgtttcaa gcagccgata ccttatgtcg tcattaagcg tgaagatgaa 1635841 gtttttcttt acgagcggct ggctggcggc ggtgaatcac gtctgcacaa caagctttct 1635901 ctcggttttg gcggccatat gaacgccatc gaaggggcag cttcatttgc tgaagtctta 1635961 aagctgaaca cagaccgtga gcttgaggaa gaactgcaaa taaatgaaga agataaacag 1636021 gcgattgtca cactgggatt gatcaatgat gatgaaaaca gtgttggcaa agtgcatatc 1636081 ggtattcttt ctgcgcttca attaaagcct ggcgcacaag tggaagtgaa ggagaaagaa 1636141 caaattgcgg gtaaatggat gaaagtttct gaattaaaac aggatgatat ctacaaccgt 1636201 ctggaaacat ggtcacagtt tgttgttgat attcttgaat aaaaaaaccc ggtttctcgc 1636261 gatgaggagc cgggtttttt tatgagacgc tcgtccccgt ctcggctatg attctaggat 1636321 cacaatagcg tcaaagccgg catttttcgc tctggcagcg agggtgtctg cattgtcttt 1636381 ggatgaaaat gcgccaatct gcactttgta taatccgtcc tttaaaagga caatcgagtc 1636441 aaaacctttg gcttcggcat tacttgcgag cgagtcggca ttcgctttga ctttaaatgc 1636501 gccgatttga accttatata accctgagct ggaagtcttt ttaaggttaa aggcttgctc 1636561 cagcccgttt gcatgtcctc tcgctaagct ttgaataaaa ctgctcgttt tcagcttatt 1636621 tgcatcggaa acggtatcaa tgaagccgtt ctcggtcaag agggcaggca ttgccgactc 1636681 ccttaggacg tggaagttcg ctgttttttt gccgcgatcg gcaaagtcga cagcttgtat 1636741 cacttcagag tgaattgtcg attgataagt cgtcgtcggg gctcctacat ctggataaat 1636801 atagctttca aaacctgtgc ctcccccgga attaacgtga atggacaaaa agaaatctgc 1636861 tccccagtta tttgcggcat ttgtccggtc gtttaagctg acatattggt cgcttgtccg 1636921 gctcagcagc agagaaacgc cttcatattc attagttaat atcgtacgta aggctaaagc 1636981 gatttgcagg gttaacgttt tctcctgaag gccattacct gttgcgcctg gatcagaccc 1637041 gccatggcca ggatcaataa aaattttaac catttttcat cacctcatta caggatatga 1637101 aaaaacacgg cttctgcttg tacgattatc attcaactga aaaatgagga aataaccctt 1637161 tcacatccag aaattatttc tcgggaaagc gcacaattca acatgaagcg acaacagata 1637221 cggtccgaca tgaaatctgt gcatacgcca tatgtttgta tgtactatgg gttcggttaa 1637281 cctgcactga ttcctgctgg ttttaagctt tgcgttcata ttaaatcaag catttaaaac 1637341 gtaaattgat gaggaaagct cctttcatta aagacaccgc tttataaatc gaaaaaaaga 1637401 aaaacacttc aggtatctta gggcgggtaa tacgtttcgt acaaaaatca gcccgttgta 1637461 tgaaaaagaa ataatgagaa agaagctcac tataatactc tgacaaaatg attaaaaaca 1637521 aaatctcatg gtttgtccac cccatgtccg tgaatacaat aagaaataaa gtatttctcg 1637581 ggaaagcgca ggattcctta ttgttcccga aaaaagcaat tgtttcgaca catgataggc 1637641 gtttgtcaca atcggcatcc gcttgaatat catatagaga gaacagagag gtgaagatgt 1637701 tggagcgcgc tgtgacttat aaaaacaacg gacagatcaa cattattctg aacgggcaaa 1637761 agcaggtgct gacgaatgct gaggcagagg cggaatatca ggctgcattg caaaaaaacg 1637821 aagcaaagca cggcattttg aaggaaatcg aaaaagagat gagcgcatta gttgggatgg 1637881 aggaaatgaa acgcaacatc aaggaaatat acgcctggat ttttgtgaac caaaaacgcg 1637941 cggagcaagg cttgaaggtt ggaaagcaag cgctgcacat gatgtttaaa ggaaatccgg 1638001 gaacgggaaa aacgacggtt gcacggctca tcggcaagct gttctttgaa atgaatgtcc 1638061 tgtcaaaagg ccacttaata gaagcggagc gggctgacct ggtcggggag tatatcggac 1638121 acaccgccca aaagacgaga gatttaatca aaaagtcatt aggtggcatt ttgtttatag 1638181 acgaagccta ctcgctggca agaggcggcg aaaaggactt tgggaaagaa gcgatcgaca 1638241 cacttgtaaa gcatatggaa gacaaacagc atgagtttat tttgatactc gccggatatt 1638301 cacgggaaat ggatcatttt ctctcgttaa atcccggact ccaatcaaga tttcccatct 1638361 ccattgattt tccggattac tctgtgaccc agctcatgga gattgcgaaa cgaatgatcg 1638421 atgaaaggga ataccagctc agtcaagaag cggaatggaa attgaaagat tacttaatga 1638481 cagtgaaaag cacgacaagt cccattaaat tcagcaatgg acgttttgtc agaaatgtga 1638541 tcgaaaaatc gatcagagca caagccatga ggcttttaat gggagaccaa tacttaaaaa 1638601 gcgacttgat gaccatcaaa agccaagatc tttccattaa agaagaagca tctggatctg 1638661 catagacctc tcagtttttg agaggtctgt tttttgctcg tatttccgct tttcaaagca 1638721 atcgatttgt ggtatacaca tgcagggttt ggtatgataa tactactgcc caatatgcaa 1638781 aagaaaggaa catccatttg aacgaacaag aaacgattca ggagaaagcc attttagtcg 1638841 gatgtcagct gccgcatatc acggatgagc attttgaaaa ttctatggaa gagctagcat 1638901 ctctgacgaa aacagcagac ggaaaagtac tgaccagcgt cacacaaaaa cggaacaggg 1638961 ctgacgccgc tacatatata ggaaaaggga aggtagaaga gctgaaggca ctcgtggaag 1639021 agcttgaagc tgatctcctc atctttaatg atgaactgtc gccaagtcag ctgaagtcat 1639081 tggcaacagc aattgaagtg aagatgattg accgcacgca attgatatta gatatttttg 1639141 caaagcgggc gagaacgaga gaaggcaaac ttcaaattga gctggctcag ctgcaatatg 1639201 cactgccgcg tctgacggga caagggatca acctttcccg gcaaggcgga ggaattgggg 1639261 caagaggtcc cggggaaacg aaactggaaa ccgaccgccg ccatatcaga aatcgcattc 1639321 atgaaatcaa cacacagctt tccactgtca ttcgccatag aagccgatac cgtgaaagaa 1639381 gaaagaaaaa cggtgtgctt caaattgcgc ttgtcggcta tacaaacgca gggaaatcaa 1639441 catggttcaa ccgcctgacg agtgctgaca gctatgaaga agacctcctg tttgccacgc 1639501 tggacccgat gaccagaaaa atggtcctgc caagcggcta cagtgttctt ctttcagata 1639561 cagtaggatt tattcaggat cttccgacga cattgattgc tgcattccgc tcaacgcttg 1639621 aggaagtaaa agaagcggat ttaattctgc atttaattga ttcttcaaat gaggattatg 1639681 cgggacatga aaaaacagtg cttcggctgc ttgaggagct tgaagcagat gatatcccga 1639741 tgctgacggc ttacaataaa cgtgatcaaa aactgcctga ttttataccg accgccggaa 1639801 gggatcacat tatggtcagt gcgaaatttg aggacgacgc tgcagccttt aaagaagcga 1639861 ttcagcgcta tttgcgccaa gaactgttaa cgtcttttga agcacatgtg ccggcaagtg 1639921 aagggaagct cctttccaga atcaaatcgg aaacgatggt agaccgcttc tattttaatg 1639981 aagaaaatga acagtatgac atatccggct atgtccaaga agagcaaagt atcatcggtg 1640041 aattaaagaa gtatatgtag gaaggaaata taaagacatg tttgacacat taacacacgg 1640101 agaattattg aagaaaacgg caatggaagt ggaagcggac attgccggca ttcataaaca 1640161 aatagaagaa atcagcgagc gaaatgagtg gagagtgctt caaagctata gaaaacacaa 1640221 agtaagcgac actcatttca cgccgtctac tggatacggc tatgatgata tcggaagaga 1640281 cacgcttgaa agcatatatg cggatgtgtt tggcggagaa gcggggcttg taaggccgca 1640341 aatcatttca ggcacacatg ccatctcaat tgctttgttc ggtgtcctca gaccggggga 1640401 cgagctcctt tatatcacgg gcaagccgta tgatacgcta gaggaaattg tgggcgtcag 1640461 gggtggagaa aacgctggtt cgttaaagga ttttcaaatc ggctataatg cggttgatct 1640521 gacgaaagac ggaaagatag actatgatgc agtcgccgct gcgatcaatc cgaagacaaa 1640581 agtaatcggc attcagcgct caaaaggata tgcgaatcgc ccttctttct taattagtga 1640641 aataaaagaa atgatccgtt ttgtaaaaga aatcaatgaa aatctgatcg tctttgtgga 1640701 caactgttac ggagaatttg tggaagagct tgagccttgc catgtcggag ccgacctgat 1640761 ggcgggatct ctcattaaaa atcccggcgg cggccttgcg aaaacaggcg gctacctcgt 1640821 cggaaaagcg aaatggattg aagcttgctc ataccgtatg acgtcacccg gcatcggcag 1640881 agaagcgggg gcatctcttt actcgctcca agaaatgtac caaggcttct ttttggcgcc 1640941 tcacgttgtg tctcaaagtt taaagggagc ggtgtttaca gcgagattcc ttgaaaaact 1641001 cggcttcact tcaaacccga aatgggatgc gaaaagaacg gatttaatac aatccgttga 1641061 gttttctgac agagaaaaga tgattgcttt ttgccaggct attcaatttg catcgccaat 1641121 caatgctcat gtgacgcctt atccagccta catgcctgga tacgaggatg atgtcattat 1641181 ggcagcaggg acgtttattc aaggagcaag catcgaatta tcagctgatg gccctatccg 1641241 cccgccgtat gtagcgtatg ttcagggagg attaacctat tcgcatgtga agaatgccat 1641301 atgcagtgca gtggattcat tgatgcaaaa gcaattaatt taaatttttt aaaaatttct 1641361 ctggatttga tgttaagaat ccttacatcg tattgacaca taatataaca tcacctataa 1641421 tgaaactaag ttaagaaaag gaggaaattg agatgagtga taatattcgc cgctcaatgc 1641481 ctttatttcc aataggaatt gtcatgcagt taactgagtt atcagcaaga caaattcgat 1641541 attatgagga aaatggactg atatttccag ccagaagtga aggaaataga cgattatttt 1641601 catttcatga tgtagataaa ctgttagaaa tcaagcacct gatagaacaa ggtgtaaaca 1641661 tggcaggaat taaacagatt ctggcgaaag ccgaagccga gccagaacaa aaacaaaacg 1641721 agaagacgaa aaaaccaatg aaacatgatc tgtccgatga cgaactgaga cagctcctga 1641781 aaaacgagct catgcaagcc ggccgttttc aaagagggaa tacattccgt caaggcgaca 1641841 tgtcccgctt ctttcattaa tccgttagca actgttttgc tatatacatt taccttttaa 1641901 gaggaggaat tttaccaaat ggcaaagtac actagagaag atatcgaaaa attagtaaaa 1641961 gaagaaaacg tgaagtatat ccgccttcaa tttactgaca ttcttggaac aatcaagaat 1642021 gttgagattc ctgtaagcca gcttggaaaa gcgcttgata ataaagtcat gtttgacggt 1642081 tcttctattg agggattcgt tcgtatcgaa gagtcagaca tgtacctgta tccagatcta 1642141 aatacatttg ttatcttccc atggacagct gaaaaaggta aagtagcacg tttcatctgt 1642201 gatatttaca atccggatgg cacacctttt gaaggtgacc cgcgaaacaa cttaaaacgg 1642261 attctgaaag aaatggaaga cctcggcttc agtgatttta accttgggcc tgagcctgaa 1642321 ttcttcttat tcaaattgga cgaaaaaggc gagccgacgc ttgaactaaa cgacaaaggc 1642381 ggatatttcg acttagctcc aactgattta ggagaaaact gccgccgcga tatcgtactt 1642441 gagcttgaag agatgggctt tgaaatcgaa gcgtctcacc acgaagtagc acctggtcag 1642501 cacgaaatcg actttaaata tgctggagca gtccgctctt gtgatgacat ccaaacattt 1642561 aaactagttg tcaaaacaat tgcccgtaaa cacggcctgc atgcgacatt tatgccaaaa 1642621 ccattgttcg gtgtaaacgg ttcaggtatg cactgcaatc tatcactctt caaaaatggt 1642681 gttaacgcat tctttgacga aaacgcagat cttcagttaa gtgaaacagc gaagcacttc 1642741 attgcaggta tcgtgaagca cgcaacaagc tttacagcag taacaaaccc gacagtaaac 1642801 tcttacaaac gtcttgttcc tggctatgaa gcaccttgtt atgtagcatg gagcgcgcaa 1642861 aacagaagcc cgcttatccg tatcccggct tctcgcggca tcagcacacg tgttgaagta 1642921 cgcagtgtag acccagctgc aaacccatac cttgcactta gcgtattgct tgctgcagga 1642981 ttagacggaa tcaaaaacaa actggaagcg ccggctccaa tcgaccgcaa catctatgtg 1643041 atgagcaaag aagagcgcat ggaaaacgga atcgttgacc ttccagcaac acttgcggaa 1643101 gcactagaag aattcaaatc aaacgaagtc atggtcaaag cgctgggcga gcacctattc 1643161 gaacacttca tcgaagcaaa agaaatcgaa tgggatatgt tccgcacgca agtacatcct 1643221 tgggaacgcg aacagtatat gtctcagtat taatatctca atcccttggc actaaaagtg 1643281 tcaggggatt ttttatgtta ataggtaata aattatggag cggcatagtg tttaacacag 1643341 ccattaatcc tcagacagtc aaatagccat ttctactccg gttgaaagct tctctatttt 1643401 tgcttcttat ttatctttcc tgtattgata tatgtatgta gggttggact tataacataa 1643461 actattctgg ccattccgtt ctttcaattc atgaccgggc ttgccatcag cataaatcta 1643521 ggctaacagt ctccatacat cctgtgatca cctttatcaa actcttaaat gcaacttacc 1643581 actaaccaat tctttatttc gcatagatca tctttgtcat gtgtttacac aagaatctgt 1643641 tttggactga gacactgaat ataacaaaac agtcaaaaat caatatttaa ttcattctgt 1643701 ttaaactttc tgaaaaagat gttgaaaaag tcgaaaggat tttataatat taagtcaagt 1643761 tagtttgttt gatcaacaaa ctaatgaaat gaactttcat tatccacaag ataagatctt 1643821 actaatatgg atggaagggg gataagaggg tcgatttaat ggagctaaac aatataagaa 1643881 acgaaagaat gaggctttta tccttttcca ggtatataag gtatgacgaa aaaagatgaa 1643941 ttttttgctt gctgatcacc atattttttt gcactgtttt gaaagcgctt ttataaaagt 1644001 ttactgaccg taaattcgag aaattgttat accgtttcac actgttccat attaaaggat 1644061 cgaaaagggg agaaatcatg ctcagtgaaa atgtaaagaa gattagcatg gttgaaaaag 1644121 ttggatatgc gtctggagat tttgcttgta atttaattta tgcaacagtg tctacgtatc 1644181 ttttgttctt ctatacagat gtttttggtt tatcggcagc agcagccggt actatgtttt 1644241 tagtggttag aataatcgac gctctcgctg atccttttat cggaacaata gttgacagaa 1644301 cgaacagcag atttggacgc tttagaccgt atcttttatt cggagctttt ccatttgtca 1644361 tactggcaat actctgtttt acaacaccag acttttcgga tatggggaaa ttaatatatg 1644421 cctatataac ctatgttggc ttgtcgctta catacacaac gataaacgtt ccatatggcg 1644481 cgttaacttc tgcaatgact agaaataatc aagaagttgt tagtataact tctgttcgca 1644541 tgttatttgc gaatcttggg ggacttgtcg ttgcattttt tgttccctta ctggctgctt 1644601 atttaagcga tacttccggc aacgagtctc ttggctggca actaaccatg ggtattttgg 1644661 gaatgatagg cgggtgcctt ttaatctttt gttttaaaag cacaaaagag cgggtcactc 1644721 ttcaaaaatc cgaagagaaa attaaattta cggatatatt tgagcagttt cgtgttaatc 1644781 gtccacttgt tgtattaagt attttcttta ttattatttt tggagtgaat tccatcagta 1644841 attcggttgg catttactac gtaacgtata acttagaaag agaggatttg gtgaagtggt 1644901 acggtttgat aggaagttta cccgctttgg tcattttacc gtttattcca aggcttcatc 1644961 aatttttggg gaaaaagaaa ttactaaact atgcattatt actgaatatt ataggcctct 1645021 tagctttact gtttgttccg ccaagtaatg tttacctcat acttgtctgt cgattaatcg 1645081 ctgctgctgg aagtctcact gccgggggat atatgtgggc gcttattcct gaaacaattg 1645141 aatatggaga gtacaggact gggaaaagaa tgggtgggct catttacgct ataatcggat 1645201 ttttctttaa gtttggtatg gccttaggag gagttgttcc gggtctggtt cttgataagt 1645261 ttggatatgt agcaaatcag gcacaaaccc cggcggcctt aatggggatt ttaattacaa 1645321 caaccattat tcccgtgttc ttgcttgttc tagctttaat tgatattaat ttctataact 1645381 tagatgagaa aaaatataaa aacatggttc gagaattaga gaatagagac aaagtttatt 1645441 tggatcatat tgatgatttc aaggcttaaa aaagaaaata aactgaggag gagtcccaaa 1645501 tgaagattac caatcccgta cttaaaggat tcaatcccga tccaagtatt tgtagagcag 1645561 gagaggatta ttatatcgct gtatctacat ttgagtggtt tccgggagtc cagatacacc 1645621 actcaaaaga tttagtaaat tggcacttag ttgcacatcc attacagaga gtttcacaat 1645681 tagacatgaa aggaaaccca aattcaggtg gagtttgggc accatgttta agctatagtg 1645741 atgggaagtt ttggctgatc tatacggatg ttaaggtagt agatggcgca tggaaagatt 1645801 gtcacaatta tttagttact tgtgaaacga ttaatggtga ttggagtgag ccgattaaat 1645861 taaatagctc ggggtttgat gcttctttgt tccatgatac ggatggaaaa aagtatttat 1645921 taaatatgtt atgggatcac cgtattgatc ggcactcatt tggaggaatt gttatacagg 1645981 aatattctga taaagagcaa aaattaatcg gtaaaccaaa agttatattt gaaggaactg 1646041 atagaaaact gacagaagct ccgcatcttt atcatatcgg gaactattat tatttattaa 1646101 ctgcagaagg aggaacacgg tacgaacatg ctgctacaat tgctcgttct gcaaatattg 1646161 aggggccata tgaagttcat cccgataatc caattttaac gtcatggcat gacccaggaa 1646221 atccattgca aaaatgtggt catgcatcca ttgttcaaac acatacagat gagtggtatt 1646281 tagctcattt aacgggacgt cctattcatc ctgacgatga ttcaattttt cagcagagag 1646341 gatactgtcc tttgggcaga gaaacagcta ttcaaaaact ttactggaaa gatgaatggc 1646401 cctatgtagt aggtggaaaa gaaggaagct tggaggtaga tgcaccttct atacccgaaa 1646461 caatatttga agcaacgtac ccggaagttg atgaatttga ggattcaaca ttaaatataa 1646521 attttcaaac tttaaggatt ccattcacga atgaattagg ttcattgact caagcgccaa 1646581 atcatttacg attattcggt catgaatcat tgacctcgac atttactcag gcatttgtag 1646641 ccagacgctg gcaaagtctc cattttgaag ccgaaactgc tgttgagttt tatccggaaa 1646701 attttcaaca agccgctggg ttggtgaatt actacaatac agagaactgg acggctcttc 1646761 aagtcacgca tgatgaagaa cttgggcgca ttcttgaatt aacaatatgt gacaactttt 1646821 ctttttcaca gccattaaat aataaaattg ttattcctcg tgaagtaaag tatgtatatt 1646881 taagagtaaa tattgaaaag gacaaatatt attatttcta ttcttttaac aaagaagatt 1646941 ggcacaaaat tgacattgca ctggaatcga aaaaattatc agatgattat atccgtgggg 1647001 gaggattctt cacaggggcc tttgtaggga tgcaatgcca agataccagt ggtaatcata 1647061 ttccggccga ctttagatat tttcgttata aagaaaaata atttgcacat gaaaaaggag 1647121 atttctattt tagaactcct ttttcatatg agaaggtgcc atgtcactat tgcttcagaa 1647181 atactcctag aataaaaaaa ctcatcttta aagatgagct gtccattcca taaaaaatta 1647241 cattgtaatc atgtccagaa aatgatcaat cacaatggag gacattccta atgccggtgc 1647301 attctgtcct aaggaagatg gcaataattc atagctattg cctaattggg aataaaccct 1647361 tgatgatact tcacttctca ttgaatttaa aaccatagga tgcgattcaa ttatgctatt 1647421 tcttaaaatt acggcttgtg ggttgaaagt atttagaata ttggtaaggc ctattcctaa 1647481 atagaatcca aaattttgta atgcatttaa ggttccgata tcattcagat gggcgaggtt 1647541 tatgatatct tgataggaca gttttttctc tttggtctga agagatttta ataaagcctt 1647601 ctctgaagca tacaattccc agcatcctcg gtttccgcaa ctgcatttag gaccattaaa 1647661 gtctattgtc atatgtccca tttctccaga gaagccgctt actcctctat ataaatgatt 1647721 gttgataata acaccgatcc ctattcctgt gctgatactt acgtaaataa tgttatcgtg 1647781 attttttgca gctccaaata ctttttctcc atatgcgcca gcatttgcct cattttcaat 1647841 aaaaacaggc acattgtact tctcttgtat cgaagatttt aagtcaatat ctctccagtt 1647901 ggagttcgga gtgaaaacaa ttttttgatc tttatcaatg agtccaggca cgcaaatacc 1647961 tataccaata agcccgtacg gagattgggg catttgcgta ataaagtgat gaatcatatc 1648021 aatcaaaatg tctttcgtta tttctggaga attggattcc aaatggcggt attgatcaag 1648081 aacgattgtt ccttcaaggt ctgttaaaat gccattaata taatccacac caacatctat 1648141 tccaacggag tatcctgcct ttttattaaa aacaagcatg acaggtcttc ttccgccact 1648201 tgattgtcct tgacctattt caaataccat actttctttc attaacgtgt ttacctgtga 1648261 tgagacagtt gatttattta atccagtcat ttcagataat tttgctcttg aaataggtga 1648321 atttttaagg atttctttta ataataactt ttgatttact tttttgacaa aggtttgatc 1648381 agcgatatcc acttcatcca ctccatttgt ttaatcttta aattaagtat caacatagta 1648441 catagcgaat cttcccttta ttatatctaa tgtgttcata aaaaactaaa aaaaatattg 1648501 aaaatactga cgaggttata taagatgaaa ataagttagt ttgtttaaac aacaaactaa 1648561 taggtgatgt acttactata tgaaataaaa tgcatctgta tttgaatgaa tttattttta 1648621 agggggaaat cacatggctc aatctcattc cagttcaatc aactattttg gaagcgcaaa 1648681 caaagtggtt tacgaaggga aagattcgac taatccttta gcatttaaat attataatcc 1648741 tcaagaagta atcggcggaa aaacgctgaa agagcatttg cgattttcta ttgcctattg 1648801 gcatacattt actgctgatg gtacagacgt ttttggagca gctacgatgc aaagaccatg 1648861 ggatcactat aaaggcatgg atctagcgaa gatgagagta gaagcagcat ttgagatgtt 1648921 tgaaaaacta gatgcaccat tctttgcttt tcatgaccgg gatattgcac cagaaggcag 1648981 tacgctaaaa gagacaaacc aaaatttaga tatgatcatg ggcatgatta aagattacat 1649041 gagaaatagc ggcgttaagc tattatggaa tacagcaaac atgtttacga atccccgttt 1649101 cgtccatggt gccgcgactt cttgcaatgc agatgtgttt gcgtatgctg cagcacaagt 1649161 gaaaaaaggg ttagaaacag caaaagagct tggcgctgag aactatgtat tttggggcgg 1649221 ccgtgaagga tatgaaacat tgttaaatac cgatttaaaa tttgagcttg ataatttggc 1649281 tagatttatg catatggcag tggattatgc gaaggaaatc gggtacacag ggcagttttt 1649341 gattgagcca aaaccaaaag agccgaccac ccatcaatac gatacagatg cagcaacaac 1649401 cattgccttt ttgaagcaat atggcttaga caatcatttt aaattaaatc ttgaagccaa 1649461 tcatgccaca ttagccgggc atacattcga acatgaatta cgcatggcaa gagtacatgg 1649521 tctgcttggc tctgttgacg caaaccaggg tcatcctctt ttaggctggg acacggatga 1649581 atttccgacg gatttatatt ctacgacatt agcaatgtac gaaatcctgc aaaatggcgg 1649641 ccttggaagc ggcggattaa actttgacgc gaaggtcaga agatcttctt tcgagcctga 1649701 tgatctaata tatgcccata ttgcagggat ggatgcattt gcaagaggat tgaaagttgc 1649761 ccacaaatta atcgaagatc gtgtgtttga agatgtgatt caacatcgtt accgcagctt 1649821 tactgaaggg attggtcttg aaattataga aggaagagct aatttccaca cacttgagca 1649881 atatgcgcta aatcataaat caattaaaaa cgaatctgga agacaggaga aattaaaagc 1649941 gatattgaac caatacattt tagaagtata acaggataag ctccagatcc tgctatcaat 1650001 accaagtcac tgaattaccc gtcatgattc ctttcctatt gcttgttgtt atgacgggta 1650061 acttctataa ttaggattta tttagagtga atggtttttt aaaagggcaa ggagtgaaaa 1650121 aatgaagtat gtcattggaa tagatcttgg aacgagtgct gttaaaacca ttttagttaa 1650181 ccaaaacggc aaggtttgtg cagaaacgtc caaaaggtat ccgctcatcc aagagaaggc 1650241 gggatatagt gagcaaaatc ctgaagactg ggttcagcaa acaattgaag cattggctga 1650301 attggtttct atatccaatg ttcaagccaa ggatattgac gggataagct attcgggaca 1650361 aatgcatgga ttagtactgc ttgaccaaga tcgtcaggtg ttacgtaatg caattctttg 1650421 gaatgatacc agaacaacgc ctcaatgtat aaggatgacc gagaaatttg gcgatcatct 1650481 tcttgacatc acaaaaaacc gtgttttaga agggtttaca ttacctaaaa tgttatgggt 1650541 aaaggaacat gaacctgaac tttttaaaaa aactgctgtg tttttgcttc cgaaagacta 1650601 cgtgcgattc cgtatgaccg gtgtcattca caccgaatac tccgatgcag caggaacttt 1650661 acttttacat attactcgca aggagtggag caatgatatt tgcaatcaaa ttggtatttc 1650721 tgcagatatt tgtcctccgc ttgttgaatc tcatgattgt gtaggatcgc tgcttccgca 1650781 cgttgccgcg aagaccgggc tattagaaaa aacaaaagtg tacgctgggg gagcagataa 1650841 tgcttgcggc gctattggag caggtatcct ttcttccgga aaaacattat gcagtattgg 1650901 gacgtcaggg gtcatacttt cctacgaaga agaaaaagaa agagacttta aagggaaagt 1650961 ccactttttt aatcatggaa aaaaggattc tttttatacg atgggcgtca cgctcgctgc 1651021 aggatacagc ttggactggt ttaaaagaac gtttgcacca aacgaatcgt ttgagcaatt 1651081 attgcagggg gtggaagcta ttccgatagg agccaatgga ctgctataca ctccttattt 1651141 ggttggtgaa agaacgccgc atgctgattc ttctattcgg ggaagcttga tcggaatgga 1651201 tggagcccat aatagaaagc attttttgag ggcaataatg gaaggtatca cattctcttt 1651261 acatgaatca attgagctat tccgcgaagc gggaaaatca gttcatactg ttgtttctat 1651321 tggtggggga gctaaaaatg atacgtggct gcaaatgcaa gctgatattt tcaatacgag 1651381 ggtaattaag ttagaaaatg aacaagggcc agctatgggg gctgcaatgc tggctgcctt 1651441 tggaagcggt tggtttgaat cacttgaaga atgtgcagag cagttcattc gtgaggctgc 1651501 tgcattttat ccaaaggcgc aaaatgttca aaaatataaa acactatttg atttgtataa 1651561 gaacatttac actcacacaa aggatctcaa tacagctttg aagagctttc gaaaaaacta 1651621 atgatgttat tgtctggaga tcaaccgaag aacaattaat gatcaatcat catcaaaggc 1651681 ctttgataac atggctgcct tcttttgaaa agatggtgag aataaggtat cgcaaccttt 1651741 aaacagtatt ggagtatcca gcagacaaaa cgaacgagtg gaaccgtatt ttgtcagcga 1651801 acacttcaag aagtggggaa gcttaggaat gccaatgggt aagatgtatg aaaccgcgct 1651861 aacgacggta gagggatctc ttgatttatg aagaaatagg aaggatgtta acacacaaat 1651921 aacccctcac attgacgtga aggggtgttt tttattgtta ctatacagcg gaaattttac 1651981 aggctagttg catgatttta gcttgttaag cagaatggaa ctagactctc catcatctct 1652041 ttctcattct ttggaaactg cattctgcta ggtttgctgc tttttttaac aaacagtgtt 1652101 tttctatttc acacagccat taaatcctct gttcgtcaca taaccgctct tactccaaat 1652161 tgacagttta tctgattttg cttcttgctc atctagtctg aattggtcta tgtattttgt 1652221 gttaggctca tatacatatg ctactctggc caatccctct ttcaataatg tctcttgaac 1652281 agatttgccg tcaacataaa cgtatgctaa cagtcttcca tacttatctc tgcgatcgcc 1652341 tttatcaaat tccagctgta gcttaccgct gttgaccaat tctttatttc gtttcgacgc 1652401 atcctcaccg tatggttgaa cacaagaatt tggtttcttc gtctcaggtg tatcaacgag 1652461 caagtagcga actgtgtctt tctttccgtt gtaaataacc ttaatcgtat ctccatctat 1652521 tgctctatct aatgtaacat tgaccaattt cttctgattt tttgaatgag gcgtgccagc 1652581 cttttgttct gtctgattat attcattaga gtgagtatct tgagagactt gctccgtccc 1652641 attagaatct gaatggtttt tggctgcgtg atttgatccg caagctgcca aagtaatact 1652701 taaaacgatt gcgatcatac tgatcaaaat cttcttcata ttgattccct ctttatcatt 1652761 ttctcttttc gcgattaaac atcatcatta taacgatatg gacatttttt gtgaatggaa 1652821 aacttcaagg gaacttataa cactccaaat tgccaatagt taacttcaca acgagatgat 1652881 caaaacatca ccatcacata gcggaaataa ataatcctga aaataatatt gactgaaaat 1652941 gcttttagaa ttatgataat atgagaaatg acaataatgt gacaaagaca ttactacaac 1653001 ataacaacta atagcttagg tttattctat tggttaaaaa tgtaaacggt tacaaatcca 1653061 gaggcgaaaa tctaagatag agatgacttt agttttgact caatatccac actgaaagag 1653121 cttattaagt attcttaaag gcaggggaaa tggatatgaa tgaacatcga aatcgaaggt 1653181 tgaaattaat aatgatttca gcaacttttg gagggcttct ctttggatat gacaccggag 1653241 ttataaatgg agctttacct tttatggcaa ggccagatca gcttgattta acacctgtta 1653301 cagaagggct tgttacgagt attcttttat taggtgccgc gtttggagcg ttgttatgcg 1653361 gaagattggc tgatcgatat ggccgccgta aaatgatcct taatctttcc tttttatttt 1653421 tcctggcatc actgggaaca gcgttagcac ctaatgtttt catcatggcg gtctttcgtt 1653481 ttttactggg gctggctgtt ggaggagcct cggcgatggt gccggccttt ttagcagaaa 1653541 tggcaccgca tgaaaagaga gggcgtatgg taacccaaaa tgaactaatg attgttggcg 1653601 ggcaattttt agcatatgtt tttaatgcga tcctcggtgt aacaatggca aatacgggac 1653661 atgtttggag atacatgcta gtcatttgtg ctgtaccggc tatcatgtta tttgccagta 1653721 tgcttaaggt accagaaagc ccccgatggc taatctccaa aggcaaaaac agtgaggcgc 1653781 tgcgagttct taaacaaatt cgagaagata aacgtgcaga agctgaatgt agagaaattc 1653841 aagaagcggt agaaaaagat acagcactag aaaaggcatc actcaaggac ttttctacac 1653901 catggctgcg ccgtctttta tggattggaa tcggtgttgc catcgtgaat caaattacag 1653961 gtgtgaactc gattatgtat tatggcacac aaatccttaa agaatctggt tttggtacaa 1654021 aagcggcttt aatcgctaat attggaaatg ggctgatatc agttattgca gttatatttg 1654081 ggatttggct ggtcggaaaa gtgagacggc gtccaatatt attgattggt ttggcaggga 1654141 cgactacagc gctcctattg attgcgattt tctcaattgt gcttgatgga tctatggcac 1654201 ttccttatgt agtgctttct ttgaccgttt tatttcttgc ctttatgcaa gggtgtgtag 1654261 gacctgtgac ttggcttgtc atagcggaaa tattccctca aaggttaaga ggacttggtt 1654321 ctgggataag tgtttttttc ctttggatat taaactttgt gatcggtttt gctttcccga 1654381 tcttgcttag ctctgtaggt ttgtctttta cattctttat atttgtggct ttaggtgtat 1654441 tggcaatcgg ttttgtgtac aaattcatgc cggaaacaaa agggcgtaca cttgaagaat 1654501 tagaagagca ttttcgttct cgacacgatc ataatactcc tgaacaatca gttattgagg 1654561 tataaatatg ttgaaaatct ctcttcttat aggagggatt tttttagttt cagaaaaaac 1654621 aaaatccctc tggtagaggg attttgattc agcattttaa gatgttctac acgtataata 1654681 ctggagttga tactttaaaa atctcgccat ctcttatata aaaacgaggg atgcggcggc 1654741 ttaatgtaga cacgacttca tagttaatcg tattgagcat ttcagccact tcatcaacgg 1654801 aaatctcggc tcctttttgc ttaccgtaaa tcacgacttc atctccttgt ttaccttcac 1654861 cgttttctcc taaactgacc atgatcatat ccattgttac tcttcccgcc actggcactc 1654921 gttttccgcg atgaagaaca aacccgcgat tggaaagggc acgagaatag ccgtcagcat 1654981 agccaatcgg gagtgtagca attacttcat taggttctgc gatgtatgta gcaccatagc 1655041 taacggttcg gggttctgtc cgcatggttt tcacataagc gatgcgtgcc tttaaactta 1655101 acgcaggttc aagcttaacg agatttagtt gtttaatata ggctgaagga tataaaccat 1655161 ataagccgat acctaaacgg atcatatcag cgctaaattc cggaaatgcg atagctgcag 1655221 ccgtgttgca catatgcacg gtgggcagct caatcccctg tttttttaaa aagctgagaa 1655281 aactgatgaa tttttcatgc tgcagctttg tgagtgttgt gtccggttca tcagctgtcg 1655341 aaaaatgtgt gaaaatccct gtccatctga ggaatttact tgcctttaag gctttcacta 1655401 cctctaaaag ttcttccttt gtgcgtacac ctaatcgtcc catgccggta tccacgttaa 1655461 tatgaatggc cagccggtta gcactcgctt ctttttccaa tatctcgttt gcttctttca 1655521 tccaatcaac ctgaaatgct gataatgtta tattccaagc tgctgacttc tttacacaac 1655581 taagggatgt aaaaccaagc acaaggatag gtgctgtaat cccagcttta cgtaaaacga 1655641 ttccttcctc cacactggca acagcgagct cactcgcccc gtgttccagt gcatggcgtg 1655701 ccacttctat agacccgtgg ccataaccgt tcgcttttac aacagccata attttgctct 1655761 tatgtggaat atgacggcgg atcgctcgca aattcttttt aacggcatca agattgactt 1655821 cgatccaaac ttctcggcaa agctttatca tcaacgcttc cttccttctt atggattata 1655881 aataccacct attgccgcaa gaataaatgt taattgttgg atgattcgat cttattttat 1655941 tcaactttat ttgaaatcat tcaacagcaa atccatgtga tacgagaagg tgcctatcaa 1656001 tgttcgaata atagcaagta cgggatacat gaggcttgta agtggggtgt taatggatgc 1656061 ggcgaccgag gattacaaaa atgattattt gttttgggac atttttttct aagggtagat 1656121 gataacgaga aatctaatca ggaaatactt accgttgtta tgaacattga agaacctttt 1656181 aaatgagaag ggctgaggaa attctgtaaa agataatcgg ttgaaaaggc agtcgattcc 1656241 ttgttccata aacctaacat cagagtatat aattatactc gtattcacaa aaatcgttta 1656301 agtaaggggt atacatgaat aggggagtta gttttcaaat accgaatgaa tatggaaatt 1656361 ttctatggag aatactgcag ccggtagaaa tagctaatta taggtggcaa acgagtgggg 1656421 aatcttattt tgttgtagaa ggagagctcg atgatgagga gctttttcat gactacgaaa 1656481 ttgttgaggg ggcagttttt gagcaacaat taaaaacgaa tcagtactat accattttcg 1656541 ttgaactgaa agcatttcca tatggaaaaa tggttaatca agtcaataca tatgaagagt 1656601 ttgctgacag tgattgcgaa cttgtccttt tgatagcaga taatagctac gtttcgattt 1656661 actgtaaaaa caaaaatatc attgaaaaac tttacttcaa tgctttacag catgattttg 1656721 aagacgttca atttataact gatgaaaatg acacaagaac aagccttact gtatgatact 1656781 caataaaaat taaaggagct agtacatgac aatgcaaatt aaaatcaagt atctagatga 1656841 aacacaaaca agaatcagca aaattgagca gggagactgg attgatcttc gggcagctga 1656901 agatgtaaca atcaaaaaag atgaatttaa gcttgtccca ttaggtgttg caatggagct 1656961 gcctgaaggt tacgaagcac atgtcgtccc tcgttcaagt acatataaga actttggcgt 1657021 tattcaaaca aattcaatgg gtgttatcga tgagtcatat aagggagaca acgatttctg 1657081 gttctttcct gcttatgcat tgcgtgatac tgaaattaag aagggtgatc gtatctgcca 1657141 gtttagaatc atgaagaaaa tgccggcggt tgaattggtt gaagtcgagc atttgggaaa 1657201 cgaggataga ggaggactcg gttcaacagg tacgaagtaa acaaaataaa tccttggctg 1657261 tcttcatgct gtgtgattga tcaatggagg tttcagccaa ggtacatata aatattatgt 1657321 ataaaatgaa tattttaata cgaaggattt aattaaaaac aaagtttaaa aagggaagtt 1657381 ttgaaaaagt gaaatagtaa taactaaagt cgataaagaa cctaaagatg tcaaagaaac 1657441 aatttttctg gtgctttgct tttttgaagg tttacttagc tcgtggataa ctgcccccca 1657501 taaaagcatg gatgctaaaa ttataatact tatatacata aagatgctcc ttttattata 1657561 tttacagttt ttacattttt atcgatttta ccacatttag gattgagttg tcgatgaaac 1657621 aagcatctct ataaagaaat acttttatct aaatttttat aaatagggga aggcaactaa 1657681 aaactagtaa tgccactaat aataagccaa gttaaatgac ttgtgttcat taataattga 1657741 attttacagc agccatgagc acaaaaaaat ctgagttcgt cgataaatat cataaaaaag 1657801 cccccggtat gtcgccaggg aataaataga cgtttaagag atttagtgat gttttttata 1657861 tgattcgaca aaatcataat aatgatcatc gtcatcataa tacttttttt cgtaatgata 1657921 atcgtgatca tcgtaatact ttttatcatg gtcatcatac tttttgtcgt aatcataatg 1657981 ttttttatca tgatcataat acttgtcgca atcataatgc ttcttatcat tgtcgtaata 1658041 ctttttgtaa tatgtttttt tccaagtata atactcttct ttatattttt tataataacc 1658101 caattaaatt cctcctttat gttattcgaa tttaatttat gaagtttaaa tgatatggta 1658161 tggtcaaatg aaataagaat agtaaaaaga ggctgtttaa aacactttct gaaaaacaaa 1658221 acggatagct gtttatgaaa ataagagcga gagagagcac tcaatcactg taaaataata 1658281 gtaaagtgta tagagagatt agtatacgta aaaagggact ttctcattga agaatatttg 1658341 aacgttatgg ttaagattca agagctctat gatgtgattt ttcacactgc ttttgaagga 1658401 tttagagtta gacatcaaaa acaaacagca aaaccggcta gaaacagatc atataaggaa 1658461 tgaaccgctg ccaaatatca taaaaaagtt gttaatgatc aaatgaatga aattagagag 1658521 aatttatttt aaagaaagcc caattgcaca tggacaaatg acaattgata ttgaggtaaa 1658581 atacaatgca ttaaatcaga aaaagctatt ggaggattta atgtgtttag acaatttcca 1658641 atttggtata cacaaacacc tgactatttg aatttttatg taccgcaata tcaaaccatt 1658701 tcgtataatc ctcaacaatg ttatcaacgg tgtatgtacc aaactggcgg taactatgag 1658761 ctatgtgaca gactatgtta tggagaaata caggtgtaaa agagggggat taactcctct 1658821 ttaaacacac agtgagtgga ataagatcct cactttatct gcaagtgctt agtatttgcg 1658881 ataatattgc attcgtaata aattatgctt agcaactgaa aatgaaagaa ggatatgaat 1658941 agtcatgacg caattcgata aacaatacaa ttcaattata aaggatatta tcaataatgg 1659001 aatctcagac gaagagtttg atgtaagaac caagtgggac tcagatggaa caccggcaca 1659061 tactctaagt gtaatcagta agcaaatgag attcgacaac tcagaggttc cgattttaac 1659121 gacaaaaaag gttgcctgga aaacagccat taaagagttg ctctggattt ggcagctgaa 1659181 atctaatgat gttaatgatt taaacatgat gggcgtccat atttgggatc agtggaaaca 1659241 agaagacgga accatcggac atgcatatgg atttcagctg gggaagaaaa acagaagtct 1659301 aaatggagaa aaagtggatc aggtagacta tcttcttcat caattgaaga acaatccatc 1659361 ttcacgcaga cacattacaa tgctgtggaa tcctgatgaa ttagacgcaa tggccttaac 1659421 gccatgtgta tacgagacac aatggtacgt taaacatggg aaactccacc ttgaggtaag 1659481 agcacggagc aatgatatgg cattgggaaa tccattcaat gtattccagt ataatgtgtt 1659541 gcagcgcatg attgctcaag tgactggtta tgagcttggt gaatatatct ttaacattgg 1659601 ggattgccat gtgtacacac gtcatataga caatttgaaa attcaaatgg aaagagaaca 1659661 gtttgaagca cctgaactat ggatcaatcc tgaagtgaaa gatttttatg actttaccat 1659721 tgatgatttc aagttaatca actataaaca tggggacaag cttttatttg aggtagcggt 1659781 ttaatgctgc ctttttattg tgcagtgaat agatagcagg tatcctaatt tcattaagca 1659841 atctggaaga tgaataaaaa ttgaaggaca aacacgtata atacataaaa aagattaact 1659901 ctacagttaa tcttttttat tcagaagaaa atatcctaac tttgaaacta aatacaaagt 1659961 aaaagcaatc attacagttc tagatattac aattccatga atagctagat catatccagc 1660021 aggtatcaac gcatttgtat tacacataaa atatatagat attagaagtg ctacaataac 1660081 taaaatcatt ccaaaaagac ttgttttttc atatttcata ccaatttcca cccttattaa 1660141 agttaggttt aaacaaaaga gctgaagaaa cgaactatga ccagtatgct ccaaggaaaa 1660201 ccgccagaca atgctggcgg ctttttgctg cttcgtttat ttattaacag agatcgtaac 1660261 gttatttcct gcaactgaaa cctttgcgaa atcctgtgta tctaccacag gagtgacggc 1660321 tttattgtcg atagtgatgt tgttaaaaga ggtcgaaaag gttgctttga tcgcatcacg 1660381 ctggctttca tacgaaacag ccgcggtagc aagtgttttc cattttgaaa tcgtgccgat 1660441 gttggttcct tgaatttctg tgataatccg tccggtgtag ccgtcattgt tcgttcccca 1660501 aagggtcatg cgcgtattgc cgcttaaatt tttatagatt gtcatttgga ctgtgcttcc 1660561 agggcggaag cctttattgt atgtgaattt gtcttttcct tcgatgtacg tttcttcatt 1660621 tttggaccca accttcatga ggggcttcca gacgttgtat tgtttgctgt actgaagccc 1660681 gatatcggct tcagttccgc ttgttgccct aaagccagaa taaatatagg gagtagagac 1660741 cgagtcgttg tttttgacag tttcaggaag cacgatttta gctgtaaaaa cggcgcccgt 1660801 actgttcagg tagacacggc cgccgattcc gttaggcagc tcggatgctg cttttgcgac 1660861 ttgagcgtct gccgcgggta aacctggtat acctgatgaa agggttccga aaagaactgc 1660921 tgttcctact gcacctgcaa tcaatacttt tttcaccaaa attccccctt ttgatagtgg 1660981 tttcgccatt tattatacct tattttggaa ctggatttac gtatataaat cgacaaaata 1661041 tttcattttg aatgatgtaa ggtcgaaacg cttcgccaat ctgaaagcta tataccttta 1661101 tcagaggaaa gaatgagatc acattcgttt taaccgattt gaaattttcc tcaaaataaa 1661161 agtacaaatg cttaaagaaa cgattattaa aagaatgccc gctatcgttt ccaagcctgt 1661221 aaaaaagagg tgacgtttca tcaatgtctg tccttgtaaa atgataaaag cacagatacc 1661281 gactaagaaa agaaaacaaa tacttaggat tgctaacgct ttacgtgagt atgttttcat 1661341 ttcatcttta aaatacagca atacgaaaat aaagcagata acattggcta ttgttctaat 1661401 cacctcaaag cttttcatga caactgatat aaatagacaa agtaaaatga gataaaatac 1661461 gatgtttcta tacaaaaaac ctctcctttt atgtaggatc ctcaaagagt ttataaaagt 1661521 ttctttgtaa ctgcaataaa ttgaatgcgc tcacttatga actaactaaa ctatgtacta 1661581 aatattcact attctttttc agattcagtc accaaggttt tcatagaaag ggaagcttca 1661641 gaaatataca tatagtgcac aaacaaaaaa gacccggcaa tagccggggg aaagtaaaaa 1661701 cgaggagatg ttaatggcgt ttagtagtgt tttttatgct ttttatactc tacaacataa 1661761 tcatagtctt ttttatcgtg atcataatat tttttatcat agtcatcata ttttttgtcg 1661821 taatcacagt cataatcttt tttatcatat tcgtaatact tcttataata cgtttttttg 1661881 accgtataat actcttcttt gtattttttg taataaccca tatatactcc tcctttattt 1661941 ttactacgct ttattatacg gcgagtagat tttgcggctt ggacagttaa aatcatagaa 1662001 ggaaaaaagg gctgtccaaa tgatagaaaa agacagatga cacaaaaaca aatcaaaata 1662061 aagagccgat ttttcatcgg cccaaacgat ttatcctaca tttgtttgtc ttctttgttt 1662121 tctgagtcat tttttctgat atcctgagtc agtccgcttg ttgcttgttt aaattctgat 1662181 aaggcttttc ctgctgcacg gccaagcgcc ggcagtttat caggcccaaa tactaaaaaa 1662241 cccacaaaca aaataacgag tatttttgtg aagcttaatt ccatatcctt ttccccctga 1662301 ttgaagtaca accttttaaa caaattataa gagatagcag tacaaatggg aatgcattta 1662361 ttttgaacat tttaaaacca gcacaaagac ggattcataa aacggctgct gctgaatata 1662421 atgtccaatg ccacctgcct aagaagcagg aggcaggctg gatcaattat gtagctctgc 1662481 cggaaatgat acaaacgtag cggctatcat tgacatagag gagtggtgta gctgatgaga 1662541 ttcactaagg tagttggatt tttgtctgtt ttagggttgg ctgcggtttt tccattaacg 1662601 gcacaagcag aaaaagccgg aactgcgggg gctggagagt gggataagtt ggggacttac 1662661 acatatactt actcaagtcc gacggtatac tcgaccggag gagattttag agtgtgcctt 1662721 tcaggaagca ctcctttttc tgtttcactg cacttatatg aggatgatcc cggtgacaat 1662781 cctgatgatt atgtaggggc aaactatttt tcacccggag aatgccacac ctttggcagt 1662841 attggaaaat ttgtagatgg gagcaataac aaggccgagt tctttgttac cgattactct 1662901 ggtaaatcta aaactgttac gttttatgat tgatggactc aaattgtgaa gtataaccct 1662961 tggaaaaaaa caaaaaagag agatacctct ctctttttta ttcttcgaca gccttacgaa 1663021 gccgttcatt tacaatgcca gtccagccgc catccatctt accgcgaacg acggagcttt 1663081 tctcgtttgc tttgccgatc acttcattcg gctctttcca gccgctgtga ataagggtaa 1663141 accctgtctt ttcccccaag tcttctaatt gaaaggtaac gacccatcct tctgtatccc 1663201 attcaaaaga aagttcagtt ggagcttgaa cagccaaaac tttacaaggg gacggcccaa 1663261 acggcgattg taagtgaaat tcttgtcctt ctttgagctg aaagtcattg ggcataaacc 1663321 acttggcaat gccttctgaa gtagagactg tctcccagac tttctgaatg ggagcctcca 1663381 gagtaatgct ttttgtaata tccggtaatg cattttcgtt gttttgagcc atttcgttta 1663441 cctcttgaca tatgatgttt tttcaattca atcatataat aactaataag atcatgtcca 1663501 tagcgtgcat tatttatgct agagctgctg ttgaacagcg tgtcagtcgc cagtctgatc 1663561 tgtgaatggg agaattctgc atgcgcgaaa aagagagaga ggtgtatgtt gtcatttcgt 1663621 tcattcttgt ttgcagccgc aactgttatg tttgaactgg gattcctgtt cagccaattt 1663681 attttgcgat ttttgtttta atagtaaatg agccattttc taaaacagga ggttttttat 1663741 gcttggaaaa atcaaagcag ccattgataa tagtccaggg aagccggcca gaattttagt 1663801 tagtgaaaaa gcgtttcagc aattagagga agaaatgcgc tttgtttacg tttccaaacc 1663861 gaaaacgata atggggattc ctgtggaagt ttcagatcag gcagaaagct tcaagctgga 1663921 attttagttt tcccagactg ctaaaaggct cattttgtgt taattatgca aaatggtcag 1663981 gttgatttct ttaaaagcat gatgaaatgt tcatcatgct tttttattga gaaaaaagac 1664041 gaacataaaa aataggtata cgggaaaaat aatcctatta gagagagggg aactgacaga 1664101 tggataacat gatatcaaca cttactgact ggaatgtgtg gtttcaagcg ttagtagtat 1664161 ttctcgttcc atatgtaatc tataaagtgt ttacttggat tcatgtataa gaaggtgcaa 1664221 tgatgaggtg gcggaacaat cagtacaaaa cacagaagca gcataaatca gattattcga 1664281 cagctgaaaa gcaggatcag gatgtgttaa ccggtaacat cggatacgac ttagaacatg 1664341 taaaaagaaa aataggacat aacggggacg ttcatttccg tgagcttgaa atcactcaat 1664401 tacatgtgaa agcggcattg atctttgttg aaggactgtc tgatcaggac ttgattaata 1664461 aaggactatc agtgttagtc atgaatcaac ctaatcaggt aagcgatgaa atttctcaat 1664521 ccggcaaagg tattttaact tcgaaacaga taaaaaatca aatcgtatca atcggtgatg 1664581 tcatagattc agagaaaatc agtgatatcg tgttgaatgt tttcatgggt tcgacagcgc 1664641 ttctcatcga tggaataccg caggcctttc ttctgggaac tgtaaaaaaa caaaatcgaa 1664701 gtatcgagga gccgctttca gaagcgcttg tcagagggcc gcgcacaggc tttacagaag 1664761 agttgagtac gaatacagct cttttgagac agcaaggaaa aaatgatcaa ttaacattgc 1664821 agagatttga agtaggaaca cgattaaaaa aggatttaat tatcgcttat atgaatgaca 1664881 ttgcagatcc aaaagtagtc gaggaagtaa gaaaaagagt gagagggatt gagatcgatc 1664941 atttgccgga gtcaggctac gttgaacagt taattgagga taattatttg agcccgttcc 1665001 cgcaagtaca gagtacagaa cgtcctgatc gcgtcataag cggattaatg gaaggaagag 1665061 tagctattct gcttgacggc actccgtttg ctttgattgt tccagtcact ttcagcatga 1665121 tgcttcaatc gcctgaagat tattatgaac ggtggttccc gagctcgctc atcagattgc 1665181 tgaggttcat cgcagcaatg ataacgttat tcgcacccgc tttatatata tcatttattt 1665241 cttttcatcc tgggttaatt ccgaccaagc tggcgatttc aatttccggg acgcgccaag 1665301 gtgttccgtt cccatctctg attgaagcct tatttatgga agtcgcgatt gaaattttaa 1665361 gagaggcggg gcttcgtttg ccaaaaccaa ttggacccgc aataggcata gttggcggat 1665421 taatcatcgg ggaagcagct gtgcaggcgg ggattgtcag tccaatcatg gtcattgttg 1665481 ttgcgctcac agcaatttct tcatttgcca tcccgcatta tagcacaggt atagcacttc 1665541 ggatgcttcg gtttggcgcg atgttttgtg cggcggtgtt tggattgttt ggagtcatta 1665601 tgtattatct gctgctaagc agccatgtcg taaagctaaa gagctttggt gtgccatacg 1665661 caagtccggc agtgccctat cacttaaaag attggaaaga ctttgttatc agaatgcctc 1665721 ttttagtcat gaagcgccgg cctaaaatga tgaatacaga taatacaaaa cgggtgaagt 1665781 gatgaactcg acaggatggt gataaagtct catgttcagc ccaaccagta aaatcacaac 1665841 cgctcaggca acgattatca tcattaatta tatgcttgct gccggagttc ttacgctccc 1665901 tcggacagta acagaacaaa cacaatctcc tgatggatgg atttcagttt tattaggcgg 1665961 ggtcctagcg gtaatagccg ggatgattat agctaaatta agccagcagt atcctaagga 1666021 gaccttttat gaatactccc gacatattgt aggaaaatgg ctcgggcatc tgatcagtat 1666081 tgtttttatt acttattttc tggcactcgg tgcatttgaa gtcagagtca tgtccgaaat 1666141 cgtggatttt tttctcctcg aagggacacc ttcttgggcc atcattatga cagttctttg 1666201 gattgggctt tattcaatta cacaaggcct agatccgatt gcacggcttt ttgaaatgat 1666261 ttttccgatt acggtcatca tctttttaac gatagccctc atgagtttag gcatatttga 1666321 gatcaacaat ttgcgccctg tattaggtga tggaatcatg ccggttctta gaggtgtaaa 1666381 gacaacgaac ctttcattta catgttcaga aattatgttc attttagtag catttatgaa 1666441 aaagccgaaa aatgcggtga aagcagttgt gatcgggaca ggcgttgtga ccagttttta 1666501 tatgattacg atgattatgg tcatcggtgc actatcagtt gagggagttg tgacgagaac 1666561 atggccgggg cttgacctga tgagaagttt tgaaatacct ggtttaatat ttgaacggtt 1666621 tgaatcattt ctgcttgtga tttggattat gcagcttttt gccacgttta ttatcacttt 1666681 ttatgcagct tccctgggag tctcacaagt ttttaaaaag aaaccccttt catgtatgtt 1666741 tgggctgctt cctgttatat atatcctctc ttgcatgccg aaaaatgaaa atgacgtctt 1666801 tatattgggc gatacggtca gtcatatcgc tttgtatata tttggcgctt tgccgatttt 1666861 gctgttagtc atttcgaaat ggaggaaaag aggtgaaaag taaactaaaa cgtcaattgc 1666921 ctgctatggt catagtatgt ctgctgatga tttgcgtaac aggatgctgg agcagtcggg 1666981 aaatagaaga tctgggtctc acattcgcta tcgcaattga taaaggaaaa gaaacgaaca 1667041 ctgaaaaaga gttaaaagaa gagggcggga gctatccgaa aaaagacaac attacgctga 1667101 cctatcaatt tgttaatgaa aaagcggcag gcgcgggcac aagcggggga ggcggtagcg 1667161 gacaaggagc gcaaaaagcg tacattaata taagtgaaac aggggattca ttacagcaga 1667221 tcggaagtga ggttgcatta agacgggacc gagaagtgtt tagcccgcat ttaaaagttg 1667281 ttgtcatgag tgaagatgtg ctgcacacat ttcctatcga cgaaatgctg gatcaatttt 1667341 ttcgtgataa tgaaatcagg ctgagctgtc ttgttttatc tgctaaaggg gaagcaagag 1667401 acgctctcca gctgaaagag aacggagaaa ttccggcatt tcggctgatt ggattaggtg 1667461 aaaatgaaca taaagtttcc agaattcttc cccctatgac actcgcgaaa ctaattggaa 1667521 aactgcattc tggcagcagc tttttactgc aaaatgtggt tgcggcgaat ggagcggtca 1667581 agtattccgg agcagctgta atcaacggaa aatcgaaaaa aatgataggc accttaaatg 1667641 aatatgaaac tgaggggatt acatggatta gaggagaagg gaaaggcgga gttgtcaaaa 1667701 gtcatgataa aaagagccaa cagacgttag cgtacgatat caataaaatc aaaagcagaa 1667761 ttcagccaat cgtaaaaggg aaagatattt cattccatgt cgatattgaa tcagaaggcg 1667821 atttggttga aaactggaac acaaaagagg cgttggacac ccagtttata gatcgtctcg 1667881 aaacgactat tgaaaacgag gtaaagaaaa tagttggtca ggtattaaaa aaaattcagc 1667941 atgattataa agcagatgtt gcgggttttg atgaatcttt tagacttaca tatcctcact 1668001 tatggaaaag ggtgaaaaat aactgggatg acaccttcag taaagccgac atcacataca 1668061 gtgtgaacgt cacaattact catttcggca cggttaaaac tcagtaatga atcccaagga 1668121 agagaaggaa acctctcttc tcttttttat gcatttatta ggataaagat actttttttg 1668181 gagagatata cacttttcaa atcgaccaat atgctaatat aggaattgct tgaaatagaa 1668241 gggagaaggg gctgtgaggc agaaaccgat ttatgtagaa atcgaaatga aatctgatct 1668301 ggatacactc tgggaatata cacaaaaccc atcactgcat aaggaatggg atctccggtt 1668361 ttcaaatatt acgtatttga atagtcagcc atgcgaaaaa cagaagtttc tttacgaaac 1668421 aagggtaggc tttggattaa aggtgtcagg tacaggagaa accgtcggtg ttttcaacaa 1668481 atgttcatct gaaaggtctt cttcactggc ttttggctct gatcatccat tatctctgat 1668541 tcggcatgga agcggctact ggaagtatat acagagagaa aatgggaaaa tgacgttttt 1668601 aacacagtac caatacaaaa cagcctacgg actgctggga agatggattg atcgtttatt 1668661 atttcggccg ctgcttggct gggcgactgc ctggagcttt gatgcattaa ggctttgggt 1668721 agagcaaaat aaacatccga agcgcttcat tcgatctgct atcatctatg tgttcatgtg 1668781 tctgtttttc agcctgtttt ggttctatca aggctttgca ggtgttaaga caagcatatt 1668841 gacaggaaca gcggagatag gcttagctat tttgtggctg cttcctttaa aaagaaaatg 1668901 gatcattcat ggtgtccagg cttgtatttt tgctgggttt gcttgtctag gttccgaaat 1668961 attcatgtgg gttctattga gtgtgttttc cgctgcaagc ggcgctctta gcctgcagct 1669021 ccccagtgcc aggcgcacaa aacgaaagag aaagaagtga cattgtgagt tcgatttatg 1669081 aaaaatcaat tattaactat catttgctgc atcccaagct gcagaaacgg taccaattag 1669141 acgggtctca tacattcagc gggacgggaa cgatgtcaga aataagcgga ggctcttttc 1669201 tggttagaat gctgttaaag ctgggtgttt ttttcagatg cttcttttca gaaagaggca 1669261 aagacattcc atttacaata caaaatagaa cttgtctttt gaaatcgcaa catacaggaa 1669321 tagaatggaa tcgtacattt ttctttaaag gcaaaaaacg tttctttgat gcgttaatga 1669381 tatatgacga gaaagaaaat agaatacttg atttcttcgg caaacctcat ctgctgctgt 1669441 ctgttttgac gttcgaggca tctcttgacg gctctcttac gatcacatcg ggaaagcaat 1669501 ggctattgat atgcggaaaa agaatcccgc tgccgaaatg gctgaccggt acatccgaag 1669561 tttgcgaaac gtttgatgaa aaaaagaatt gtttcaccat tgaagtgcat gtgcaaaata 1669621 caattcttgg cactcttttc ttttataagg gaacgtttca ggaggaagag agagaatcat 1669681 gaaacgaaat ggcatagtca gtgcgctttg ttttattgga tttcttgcag cagaagcacc 1669741 ggatatttca gtggcagagg cactcgtttt gttatccatt ctatttttcg tgccgggaat 1669801 ttttcctttt gtttttcgtc aatctccggt tcgtgctgct cagtttatgg aaaacgggct 1669861 aatccagtgc tatcctgtag ccgcattctt tgcggtgctg gctctagtga cggaggttgg 1669921 gggtttcgca cttatctggt ggatgtacac agtttttaat gcattgtatg cgatcctccg 1669981 cctttgggaa acaaagatac atagaatcga agagacatca gttttgttcg gtcttattta 1670041 tttggcggga ggaggatttt ggttttttgc ttatgctgcc catttgcaga tcatgcaatt 1670101 tggccctctc atcattttgc tgactgctgt ccactttcac tattctgctt ttctgatccc 1670161 gatcttcaac ggtttactcg gcagaaccat tagaaaacat cggatgttgt acagttggat 1670221 aacatgggtg attttgcttt cgccccttct tatcgcactg ggcatcacat attcaaaaac 1670281 acttgatgtc attgcggtta gcatttatat ggcggcgatt tatcttcatg catttttggt 1670341 gttcacggca gcttttcgca ccaagacggg gacatttctt attcggcttt cttccgctgt 1670401 tttaatgata acgattgctt tctcgatgat ttattcattt ggtgtctttc ggcaagaagt 1670461 tacattgacc atcaatcaga tgatttggat tcacggtttt gtcaacgcgt ttggtgttat 1670521 cttgcccgct ctcatagggt ggagaataga ggatgcgaaa ccttttgatg cagacagtgt 1670581 aaagacattc agccgtatct acggaaaaag aaagattgga gaagaatttt tagctaacat 1670641 tcaagctgaa aataacgctc ggtacagcgg acttgtggat gatatgggca gcctgcgttc 1670701 aaaagatttt tcaccagaaa aactggcgcc gctcattctt tcgttttatg aacaaaccat 1670761 cgaatacaat attaaagcaa aagtaacatg gagcacgtgg tttcggccgc ttgcaattat 1670821 ttacgaatgg ttcagcagaa gaatcggcca aatacatctt tcgacgaacc ctgactggta 1670881 taggatgtac agcaagataa aaggtgttca ttcgaaaaaa gacggaaggg aaagagtacg 1670941 tgcctggatt agaacaaatg aaaaaaacga aaccattttt accgctcttt attcagtgta 1671001 tcgttcaaat ggagaggggt atatgaatat ttctttaccg cttccattca gcagcatgac 1671061 aggtatttta aaaccatatc atcatcagga gaagctggtt ttaacaagca ggcggagaaa 1671121 aagcagagcg ggggatgagg ggatttatct gcaaacaaga gcgggaactt gtccgcttcc 1671181 tttatctgaa acctttctga tagaagctgt acatgacaac aaattaaccg ctgttcatca 1671241 tatgtggctg tttggaataa aatttctaac tgttcattac agcattacac atattaacca 1671301 gcctattgaa agaacctaac acaaagaaga agcttcgtct gccagttgta atgagatgaa 1671361 ctgttttaaa attctgcacc gcatcaagac aggaaaggaa gggtttatgg tgttttatat 1671421 cagtttattt ctgattcttt ggctggctgc tgggtttgca gtgggaatga aacaagtgta 1671481 tgtcgatcag ctgtttgata aagctgtgat cgaaagactg gaaaaagaag cgaatgatca 1671541 tggacatgct gaccggatga tcaaacagcg cgtcctttat attgcagcag tgacagtaag 1671601 cgggtttatt tctgtttatt atgaaatgaa aacaatcccg caaaggcgaa acataagaaa 1671661 aattgaaaaa aacatcatga aattaaatca agcaaaaaaa cgaagaatga agagaaaata 1671721 aaaagtgcac aggccaaagg gcaggtgcat ttttgttttg tatggaaaat gggggaggtg 1671781 gtgccagctt acttttcata aattcaaaaa tgagaagaac agcgcccggg ctaatggtat 1671841 ataatattgt gaatttaaca aaaatttaac aaggaggacg agagaattcg tgctaaagcc 1671901 tcaaagagac ctacattctg ttgatttgga cttagaggcg gagtagatga aaccggccaa 1671961 agtatccctg ctccgccgtt tgctccattc cttgaagcat gttgattgta acatagccaa 1672021 acgttttcca tcaactatta aaattgtaaa attattgatg atttttatgg tgtttactcc 1672081 gatttcttca atttatgctg aagatgtata tcagaatttt gaggaattaa aaaacaatga 1672141 agatccttct gattatggcg ttgttacgaa agaaaccgga agccctgttc ttgttttagc 1672201 tattcacgga ggaggtattg aaggcgggac aagtgaagta gcgagagagc tcagcaaaga 1672261 gtactcgatg tatttatttg aaggcttaaa atcggcagga aactcagtcc tgcacattac 1672321 gagcacacac tttgatgaac ctcgggccct taaaatgacg ggaaatcatg aatatgtcat 1672381 ttcattacac gggtacgcag aagaagatca gcagatcgaa gtcggcggta cagatcgcgt 1672441 aagagcggca gatttagttg agaaattgca gcatgccggt tttcctgctg tattgctcaa 1672501 tatggaccat ccgcatgcgg gcgttagtcc gaataacatt gcaaataaat caaaaacagg 1672561 tttaagtatt cagatagaaa tgagcacagg gtttcgaaag tctttgttcg gcatcttttc 1672621 tttaaaaagc agagctgtta ctcaaaatga gaggttttat gagtttacag aagtgatgtt 1672681 ccgttttctc aaaaatagct actgaaaaat aggaggcgat aagacagcct cctattcctt 1672741 atgcttctct ttcgtttcgg gaaacagctc gtccgcggct tccgtttgat actgcaacgt 1672801 gttatctctc gctgacagtt catttcggaa attttcatca agcacatttt tcagtaaata 1672861 ccgatgaaaa aagtattcaa aaacagtaag acaggcagcg gaaaggagag ccgctccaaa 1672921 tggtgagaaa tcgtttcttg tttgggttaa aacaaatacc caaagaataa cgaatgaaag 1672981 gccaaagtca gccaatgaag ctgtaatatt gtttgttctg ggtaagacga gcatgtcacc 1673041 agaaagatag gaaacaaaac ctaagaaaag tgcaataaac atcacactta aaaaggatgc 1673101 gtgatagact ctgtccaaaa tcacatataa aagggcgaga gtgaaagcaa tctttgaagc 1673161 aagcgcaatg atatgtttca tttgaccacc taaattgtta ttttttgaag aaaattcttg 1673221 ggcgtaaaca aatgataaat aatgcaattc aaaaccattc ataatggtca tgttactatt 1673281 ttaaacagtc cgtttttgtt tacactggta tttttttcag ctgtatgaaa ctttcttatg 1673341 aaaaaagtcg tatatgtgga tgatcagctt tcaagggggg aatgatttgt ggagataaaa 1673401 ggaatcaatc acttgctatt ttcagtttcg catttggata catcgattga tttttatcaa 1673461 aaagtgtttg gtgcaaagct tttggtaaag ggaagaacaa ctgcatattt tgatatgaac 1673521 ggcatctggc tagcgcttaa tgaagaacca gacatcccga gaaatgacat taagctttct 1673581 tatacccata ttgcttttac aattgaagat catgaatttg aggagatgtc agctaaatta 1673641 aaaagacttc atgtcaatat tctgcctggc agagaacgag atgaacgcga tcgaaaatca 1673701 atttatttta ccgaccctga cggccacaaa tttgaatttc ataccggaac ccttcaagac 1673761 aggcttcgat attacaaaca agaaaaaacg catatgcact tttatgatga aacggccttt 1673821 tgatagcaca accatatttc atataaggtt aaatttaaag aagggtgttg gtggagactt 1673881 tatgtttggg gaaggtttct acccgacttg ttcaacgatg ccatatcttt tgaactgcac 1673941 aagtgattgg gtgaaggtga aattgaaata cacattacat tacattttat atgaagaaag 1674001 cgagctgttt tatcaaatgt tgaactaatt aaactatgta ctaaattttc agtatatttc 1674061 aattgctttg ccccttaata aatataaaac cgcatccttc cacgacctaa aaaatgaaac 1674121 gtttttaaga agatggcgtc taatattcta aatgttcata ttttgataaa agtttcctaa 1674181 aggaaagaaa atttcttgac ttcaacaatc ttttggtgga taattatggt gtaaacatga 1674241 tgttcttttt cctcctattc gggctcgcac ccaaaagtca gggcgagcct gctttttttg 1674301 aacaacaaac cccctctccg taaaggaaga gggggttatt ttatgcatct gatagatcaa 1674361 tagattaatg gacggttctg aacacgccaa tcactttccc tagaatgctg acattctgca 1674421 aaatgatagg ttccatcgtt gggttctcag gctgcaagcg aatgtgggta tcctctttat 1674481 agaatcgttt tacagttgct tcatcatctt ctgtcatcgc aactacaatt tccccattgt 1674541 tcgctgtgtt ttgctgttta acgatgacat agtccttatc gagaatacca gcatctatca 1674601 tactgtctcc cataatctcc agcataaata catgctcgtc tggaggaacc atgcggtcag 1674661 ggagcggaaa atattcttca atattttcta ctgctgtaat aggagatccc gccgtgactt 1674721 tcccgatgac cggtacatta acgacctggc tttgcggaat gtctacttct tcatcaagaa 1674781 tttctattgc tcttggtttt gtcggatctc gtctgatcag cccttttgtt tccaaacggg 1674841 ccaaatggcc gtggacagta gaactggacg caagcccgac agcctctccg atctctctca 1674901 cggaaggcgg atatcctttt gatttaacct ctgctttaat aaaacggagg atatcaagtt 1674961 gcctttttga tagcttcgtc atttttcgca cctcaaaacg tcgattttaa gaagattata 1675021 gcatgatttt ccttacagta caaacatagg ttcgaaaaaa caattgacag aaacgtttgt 1675081 tcgtatatac tgaaattata aaaatgcgaa caaacattcc tgttggaggt tatgatcatg 1675141 agtaaagaat ctattatttt tgtcggtctg tttacagtga ttttgagcgc ggttatcctt 1675201 atgctgtcat atacaagcag cggccaagag cttaatcagt atgttaaaat agaagtccag 1675261 caaggcgaca cactctggtc aattgctgat caggtagccg atacaaaaaa gataaacaaa 1675321 aatgatttta ttgaatgggt agctgataaa aatcaacttc aaacctctga tatccagccg 1675381 ggtgatgagt tagtgatccc attgaaaaag aagcatcagg atgcatatga attagcaact 1675441 gtaagataga gaggaaagag agataaaatg aaagcactca tttatgcccg tgtaagcaca 1675501 aataaagaac agcaggaaac gtcattaaag cggcaggagg aggagcttac ggccattgca 1675561 gcggagaacg gcatggaagt ggtcaaagtg atttcagaaa aagccagcgg atatgaaatg 1675621 gatcgggatg gtgtatttga gctgctcgat gagattaaga acgctgatat tgatgtcatt 1675681 ttggttcagg atgagacaag gctcggacgg ggaaacgcaa aaatcgcact gcttcattgt 1675741 atttatagag aaggtgtgaa agtctataca acggctcata gaggtgaact ggagttatcg 1675801 gaggctgact caatggtctt ggaaatcgtc agcattgtgg aagagtatca gcgaaagatt 1675861 cacaacatga aaatcagacg gggaatgaaa cgtgcagtaa aaaacggttt taaaccgcaa 1675921 aaaaacttaa aaaaccaaca tgggaacagt ggaaaagaaa aaatagaggt gccaatctca 1675981 gagatcgtcc gcctgagagc gaataaactg acgtttgctg aaatcgcggc taccctaaga 1676041 gggtttggct atgatgtctc taaagcaacc gttcaccggc gttttcagga atacatagag 1676101 aatgaagaga ctgcagagtg aatcagttgt aaaacttttt ttgatctagt actatataga 1676161 caaaatgcaa taaaggagtt taacatgatt tcaaacgcga aaattgccag aattaatgaa 1676221 cttgctgcca aagctaaagc tggcgttatt acagaagaag aaaaagccga acagcaaaag 1676281 ctccgtcaag agtacttgaa aggttttcgt tcttctatga agaacacgtt aaaaagtgtg 1676341 aaaatcattg acccagaagg caatgatgtt acaccagaaa agctaaaaag agaacaaaga 1676401 aataacaaac ttcactaata taagaggaat acggcaatat cgtattcctc ttttgcatat 1676461 actataatca aaactcttat gtgacaaaat tcaacaagtt tctctcaaat ttaagctgaa 1676521 acagttgaga aaaagtcgtc agacatttat gatgtaaggg tacaacacat aaggaagggg 1676581 atttttatgg atacaattga aaagaaatca gttgctacca ttcgcacact gtcaatagac 1676641 gctattgaaa aagcaaattc tggtcaccca gggatgccga tgggagccgc tccaatggca 1676701 tacacgctgt ggacaaaatt tatgaacgta agtccggcaa accctggctg gtttaaccgt 1676761 gaccgttttg ttttatctgc tggacacggg tcagcactat tatacagcat gcttcattta 1676821 agcgggtttg atcttagtat tgaagatctt aagggattcc gccagtgggg cagcaaaaca 1676881 ccaggacatc cggaattcgg acatactgcc ggtgttgatg ctacaacagg tccgcttggc 1676941 caaggaattg ccatggcagt cggtatggca attgctgaac gccatttagc ggaaacatac 1677001 aaccgcgatt catttaacgt agtcgatcat tatacataca gtatttgcgg tgatggtgat 1677061 ttaatggaag gtatttcttc tgaagccgct tcactcgcag gccatcttca gcttggccgt 1677121 ctgatcgtac tatacgattc taatgacatc tctcttgatg gagacctcga ccgttcattc 1677181 tctgaaaacg tgaaacagcg ttttgaagca atgaattggg aagttcttta tgttgaggat 1677241 ggaaacaata ttgaagaatt aacagcggct atcgaaaaag cacgccaaaa tgaaaagaaa 1677301 cctacattaa ttgaagtgaa aacgacaatc ggattcggtt cacctaaccg tgccggtaca 1677361 tccggtgttc acggtgcgcc gcttggtaaa gaagaaagca aattaacaaa agaagcttac 1677421 gcgtggacat atgaagaaga cttctacgtt ccgtcagaag tttatgagca tttcgctgta 1677481 gctgttaaag aatcaggtga gaaaaaagaa caagaatgga atgctcaatt cgctaaatat 1677541 aaagaagttt atcctgaact tgctgaacag cttgaactgg caatcaaagg agagcttccg 1677601 aaggactggg atcaagaggt tcctgtgtat gaaaaaggaa gcagtttggc atcccgtgca 1677661 tcttccggtg aagttctcaa cggacttgcg aaaaaaattc ctttctttgt cggaggttct 1677721 gctgacctag cgggatcgaa caaaacgact attaaaaatg ccggtgattt tacagcggtt 1677781 gattactcag gcaaaaactt ctggtttggt gtacgtgaat ttgcgatggg tgcggcctta 1677841 aacggtatgg cgcttcatgg cggtcttcgt gtattcggcg gaactttctt tgtcttctct 1677901 gattacctgc gtcctgcgat tcgccttgca gcgttaatgg gccttcctgt gacatatgtc 1677961 ttcacacatg acagtattgc ggttggtgaa gacggtccga cgcacgagcc tgttgaacag 1678021 cttgcttcac tccgtgcgat gcctaacctt tctttgatcc gtccagcaga cggcaatgag 1678081 acagcagcag catggaagct tgcagtgcaa agcactgacc acccaacagc gctagtgctt 1678141 acacgtcaaa accttcctac catcgatcaa acatctgaag aagcattggc aggagtagaa 1678201 aaaggtgcat atgtcgtttc taaatctaaa aacgaaacac ctgacgctct tctcatcgct 1678261 tccggatcag aggtaggtct tgcaattgaa gcgcaggctg aattggcaaa agaaaatatc 1678321 gatgtttctg ttgtcagcat gccttcaatg gaccgttttg agaaacaatc tgatgaatac 1678381 aaaaacgaag tccttcctgc agatgtgaaa aaacgtcttg caattgaaat gggctcatca 1678441 tttggatggg gcaaatacac ggggcttgaa ggtgacgttc tcggcataga ccgattcggt 1678501 gcatctgctc ctggtgaaac catcattaac gaatacggct tctcagttcc gaacgtagtg 1678561 aatcgagtta aggcattaat caataagtaa gcttttgaaa gaggatgagt caaatcatcc 1678621 tctttttctt gtttatccga caaaaatagt attggctgtt taacagtaat agacaattct 1678681 ttcttttctt cttttgtata atagagagca aatgaaatgc tgctggaaaa ggggatgaaa 1678741 agatggaacg tcactactat acgtacctga tcaaagagga atttgccaat cactatttcg 1678801 gccgggaatc ggttatgttt gagctgtttc aagactatca ttggacaagc cttgaaaagc 1678861 agcagtatga aatgacagag aaacagattc aatatattac acaaccaatc ccgattttac 1678921 atatgcatca gcggttaaaa atgaatttaa acaagacgga ttacaggcag ctggattata 1678981 tttatagaat agctttgccg aaagcaaaag gccacgcgac gtttatgatg aaggagcaca 1679041 tgatagaaat tgtggcttcg ggagattacg aggcagaaac gatattcttt gaagtgttaa 1679101 gaaaagtaag cccttgcttt ttagcaatgg atttcaattc gaagcgttac ggatggctaa 1679161 atccggtgaa agaaagaaat tttgtctaaa accgaagaaa aagagatgta aatgttgtat 1679221 aatagctttt ggtttagtac actttaaact agacaacatg aaggaggaaa taaaatgact 1679281 ttatgggttg gcatcctagt gggcgttgtt gcattgctca taggtgttgc actcgggttt 1679341 tttattgctc gtaaatatat gatgagctac ctgaaaaaga atccgcctat taatgaacaa 1679401 atgttacgca tgatgatgat gcaaatggga atgaaacctt ctcaaaagaa aatcaatcaa 1679461 atgatgaaag ccatgaataa tcaaacgaaa taatacgtaa agattatgat atagagaaac 1679521 atggttataa aataaaaaac ccttatacgg gttttttatt ttgcaatcat tcatcacccg 1679581 ctactgctcg aaggcgctgc ttttgatatt gtatgagaag atggtcaagc tcctgactga 1679641 gctctatcgt aatatgagat gtcattccgt tcgccatgac aatttgcagc agctctgctc 1679701 tttttttttc aatttctttt aatagatgct ctctaatcac agggatgtat cctttcatac 1679761 attagatctt caaagtgaat gtttatatta tatccatatt tatactaatt ttcaaatgag 1679821 aaggagtata atgtctcaat gtcaaattaa attatataag ttttttctga aaatagaaat 1679881 ccttcaagtg aaagtgttaa aaaaatgaaa tgattttgtc ataacttgaa ggaatgtcaa 1679941 atcatgaagg gatgatgaca tgggagacgt gaattatttt ttgacattcg gagcggggtt 1680001 tttatccttt atttcgcctt gctgcctgcc gctttaccca gcttttttgt catatattac 1680061 aggggtcagc atggacgatg taaaaactga aaagctgctg ctgcagaaaa gaagcttgtt 1680121 tcatactttg tgttttttgc ttggcttttc agtcattttt attgctttag gctatggaac 1680181 atcttttatt ggcagcctgt ttagggatta tcacgatgcg attcggcaaa ttggcgcgtt 1680241 gcttattatt ttgttcggtt tcattacact cggtgtgttc cggcctgagg ctatgatgaa 1680301 agagcggaga atccatttta agcataaacc aagcgggttt ttagggtcgg tcttaatcgg 1680361 aatggcattt gcagctggat ggacaccatg taccggtccg atattagctg ctgttatcac 1680421 acttgcaggc accaatccgg gctcagcggt gccatacatg atgttatatg tactcggttt 1680481 tgcggtaccg tttcttttat tgtctttttt tatcacaaag ctgaagtgga taaggaagaa 1680541 ccagcttttc attatgaaag ctggtggcgt tttgatgatt gtgattggtg tgctgttatt 1680601 ctttaattgg atgagcctga tcattatttt gctgtcagat ctttttggag gctttactgg 1680661 tttttgacgg taaattactt tcgtactact actaatcctt ttgtttttgg tacaataaga 1680721 ctattatctg tggaaatcga ttgttggagg ggaatatgac aagagtttta gttgtagacg 1680781 acgccaagtt catgagagtg aaaatcagag agatcttgga agaggcaaat tacataatcg 1680841 caggcgaagc ggcggacggt gaacaagcag ctgacctgta taaaaaactg cgcccggacc 1680901 ttgtgacaat ggatattaca atgccggtga aaaacggcat aaaagcgctt cgtgatatct 1680961 taacctttga tcctaaagcg aaggtcatca tgtgcaccgc catgcgccag caaagaattg 1681021 taacggaagc aattgagctg ggggcaaagg attttattgt taagccgttt gaggaaacaa 1681081 aagtgctgga agctgtaagc cgcgttatgg gacattaaag tcatttcttt tcaaaatggt 1681141 tttttttatt gttttggagt atagtatata gtatcaacac tccgagaaac aaaggaatga 1681201 taagtatgat gattatagtt tcatcaatta ttgctgtgtt aatggctgta gctgtgatgg 1681261 tggtcagaat aaagtcctct gacaagcctg tttcaccaaa aaaaatcatt cttccgccga 1681321 tttttatgag tacgggagcg ttaatgtttt tatttccggt attttgggta actggagcag 1681381 agtttttgga agcattcact ttaggtgtga ttttctctat ttttctaatc aaaacttcta 1681441 agttcgaaat taaaaataat gaaatttaca tgaaacgctc taaagcattt gtttttatat 1681501 tagtcggtct tttggtgatc agaatcgtga tgaaatcgat cttgagcaca tcaattgatt 1681561 atggtgcact gagcggaatg ttttggattc tggctttcgg tatgattgtg ccttggagaa 1681621 tcgccatgta tttatcatat cgaaaacttc ataacgagct gcagtcatct aatattcaaa 1681681 tgaattaaaa aacctttcct cttgtcagga aaggtttttt atttgagaag ggtctgataa 1681741 ggttccaaat cgattttttt gtcccgcaga tgccttttta agaaggtatg gtctctttta 1681801 ggagttgcga gaatatagcc tttgatcata agttgctgat caatctttgc taccttttct 1681861 tttaatgcaa gctcaccgat tttgcctgcg attttagctt ttgctgcatc tctgaacagc 1681921 tctggcacgg gcgcagtcaa ttcatctaga aactgtttgt tttcatcgtt ccataaatgt 1681981 ctgctgtttt caatatagta atcctgccaa tcaagctctg atctgccgtc ctcttttggt 1682041 aaacgcttta aaaactttcg aaacatgaaa aaaccgccga ttgataataa gactaccatc 1682101 atgattaccc aaaacagaat aaaccataaa aaccatcctt ccagcatcaa tcattccccc 1682161 ttattctaac catattgtat acgaagagag attagaagaa cacagtaaaa aaagaataga 1682221 aaaaagtgat agacgtctag tcaaaagaga tagtagatca tattctattg tatagtgaat 1682281 ctgctatttg gccatgggag agtcactaga gggtatttga cgataaatgg acggaaaaaa 1682341 agtcactttc ataatagggg atgaaagtga ctttttatgt ttagctgaga ggaaattgaa 1682401 gagaaaaaga agagccatct tctgtttctt tattgacggc gactgtgagt atttgatttt 1682461 cgcattcgac ttgaatgttt ttgtcattaa aataaaaagg aagcatcatt tgtttttcaa 1682521 aagtctgtcc tgacgatttg acagttaaga tgaactcgca tccagaaagg gtaactgtta 1682581 cttgtgtagg ctgtaaaaaa gtcagatccg cttctataat atactgctga cttgtttcat 1682641 ataaatcaat aggcaatgtt tcgtcgtacc aggcgaaggg gtcttcaaaa aattgccgaa 1682701 gccattcatc catactatcg aaatcattcg catcgttgcg ttttgaatgg ttcatggaag 1682761 cattcctcca catatcaacc ttgctttaca tcatatgcgg tggattataa atgggtgaac 1682821 gcataaaaaa acagacacta aggtctgctt ttcttacata tcatggcttg agttgtgctt 1682881 ttgtcttgta tggtttcggt tttttacttt tttgcttccg cttagaggct cgggttggcc 1682941 gggattgtgt cctttagggg cgtttttatg catatcttta cttgtattct tattggtcat 1683001 aaaatgagaa cctccttaaa agagttcggt gttattgatt ggtttttctt tttttgttat 1683061 tttggcgttc tgcttcagtc agtacaagct ggtcgttttc aatatagccg gcgcctttgc 1683121 cttggctttt tgcgtcattc attccgttaa tgacgtgatt cgcttttctt ttgaccatca 1683181 ttatcacctc aatcataata tggcttcttt tattgtgtta tatgagagag cgtaaacagt 1683241 aaaaattacc ggtacatttt tctcataagt cgaacttatt gtatttaata aaaacattga 1683301 tatttactta tgtatgattt tgttttaata tgaaattgtg agaaaattgt gatggaatgt 1683361 aatgttcatc tgagaatgat ctgatctgaa gggggatttt ggagaatggc aaacgagcaa 1683421 aaaactgcag caaaagacgt tttccaagcg agaaaaacgt ttactacaaa tgggaaaaca 1683481 tatcattact actctttaaa agcgttagaa gattcaggta taggaaaggt ttcgaagctt 1683541 ccttattcca tcaaagttct tttagaatca gtattgcgtc aagttgacgg cttcgttatc 1683601 aaaaaagaac acgtggaaaa tttggcaaaa tggggaactg ccgaattaaa ggatatcgac 1683661 gttccgttca aaccgtctcg tgttatttta caagacttca caggggttcc ggcagtagta 1683721 gatctggctt cactgcgtaa agcaatggca gctgtcggcg gagatcctga taaaatcaac 1683781 cctgaaattc ctgttgatct cgttatcgat cactctgtac aggtagataa agcgggtaca 1683841 gaagatgcat tagcagtaaa tatggacttg gaattcgaaa gaaatgcaga gcgctacaaa 1683901 tttttaagct gggcaaagaa agcgtttaac aattatcagg cagtaccgcc tgcaacaggt 1683961 attgtgcacc aggtcaacct tgagttcttg gcaagtgttg tccatgccat tgaagaagac 1684021 ggcgagcttg taacgtatcc tgatacgctt gtcggaacag actcacacac aacaatgatt 1684081 aacggtatcg gtgttctcgg ctggggtgtc ggtggaattg aagctgaagc gggaatgctt 1684141 ggacagcctt cttacttccc agttccagag gtaatcggcg cgaaacttgt cggcaagctt 1684201 ccaaacggaa caacagctac tgacttggcg ttaaaagtaa cacaagtgct gcgtgaaaaa 1684261 ggcgttgtcg gtaaatttgt tgaattcttc ggaccgggaa ttgctgaact gccgcttgca 1684321 gatcgcgcaa caattgcgaa tatggctccg gaatacggtg ctacatgcgg attcttccca 1684381 gtagatgaag aagcgcttaa ctacctgcgc ctgactggcc gtgatcctga acatattgat 1684441 gttgttgaag catactgcag aagcaatggc ttgttctaca ctccagatgc ggaagaccct 1684501 caatttactg atgtggttga aattgacctg tctcaaattg aagcaaactt atcgggtcca 1684561 aagcgtcctc aggatttgat cccgctatct gctatgcagg aaacgtttaa aaagcaatta 1684621 gtcagccctg caggtaacca aggattcggt ttaaatgctg aggaagaaaa taaagaaatt 1684681 aagtttaaac tccttaacgg cgaagaaaca gttatgaaaa cgggtgcgat cgccattgct 1684741 gcgattacaa gctgtacaaa tacatcaaac ccatacgtgc tgatcggcgc cggactggta 1684801 gcgaaaaaag cggttgagtt agggcttaag gtgcctaatt acgtgaaaac gtcacttgca 1684861 ccgggttcta aagttgttac aggatatctt gtgaattcag gccttcttcc atacatgaaa 1684921 gagcttggct ttaacctcgt tgggtacggc tgtacaacat gtatcgggaa ctcaggtccg 1684981 ctttcaccgg aaatcgaaga agcggttgcg aaaaatgatc ttctgattac gtctgtcctt 1685041 tccggaaacc gtaactttga aggacgtatt cacccgcttg ttaaaggcaa ctatcttgct 1685101 tcaccgccgc ttgttgtggc atatgcgctg gctggaacgg taaacattaa cttaaaaacc 1685161 gatccaatcg gtgtgggcaa ggatggtcaa aacgtatact ttaatgatat ttggccgtca 1685221 atggacgaaa tcaatgcact tgttaagcaa actgttacgc cagagctatt ccgcaaagag 1685281 tatgaaacag tatttgatga caacaagcgc tggaacgaaa ttgaaacaac agatgaagct 1685341 ttatataaat gggataacga ttcaacttac atccaaaacc caccattctt tgaagagatg 1685401 tctgttgagc caggcaaggt tgagccatta aaaggactgc gtgttgtcgg taaattcggc 1685461 gattcagtca caactgacca tatttctcct gcgggggcaa tcggaaaaga tacgcctgcc 1685521 ggaaagtatt tgcaagaaaa aggtgtttca cctcgtgact ttaactccta cggctcccgc 1685581 cgtggaaacc atgaagtcat gatgagagga acatttgcca acattcgcat caaaaaccaa 1685641 atcgcaccgg gtacagaagg cggatttacg acgtactggc cgactggtga agtaacatcc 1685701 atctatgatg catgcatgaa atacaaagaa gataaaaccg gtcttgtcgt attagcagga 1685761 aaagactatg gtatgggatc ttcacgtgac tgggctgcaa aaggaacaaa ccttctcggc 1685821 atcagaacgg tcattgcaga gagcttcgaa agaattcaca gaagcaatct tgtattcatg 1685881 ggtgtgctgc cgcttcagtt taaacaaggt gaaaatgcgg atacactcgg cttaacgggt 1685941 aaagaagtca tcgaggtaga tgttgatgaa acagttcgtc ctcgtgacct tgtgactgta 1686001 agagcaatca atgaagacgg caatgtaaca acttttgaag cagtcgtccg ctttgatagt 1686061 gaagttgaaa ttgattacta ccgccatggc ggcatccttc aaatggtgct tcgtgaaaaa 1686121 atgaagcagt cctgatgaat caataggaag agaaggcatt tcgctttctc ttctttttat 1686181 gacacaatgt gctgcggagg tggcatatgc tgaaaaaatg gctcgcaggg atcctgctta 1686241 tcatgctagt cggttatacg ggatggaatt tatatcaaac atacagcaaa aaagaagtcg 1686301 gaattcaaga ggggcaacaa gcacctgatt tttctttgaa aacgctatca ggagagaaaa 1686361 gctctttaca ggatgcaaaa ggcaaaaaag tgctgctcaa tttttgggca acttggtgta 1686421 agccgtgccg tcaggaaatg cctgcgatgg aaaagctgca aaaagagtac gccgacaaac 1686481 ttgcggttgt tgcggtaaat ttcacttcag ctgagaaaag tgagaaacag gtccgagcgt 1686541 ttgctgatac ttatgactta acgttcccca ttctgattga taaaaaaggg atcaatgctg 1686601 actataacgt gatgtcatat ccaacgacat atatcttaga tgaaaaaggt gttatccaag 1686661 acatacatgt tggcaccatg acaaaaaaag aaatggaaca aaaactggat cttgattaga 1686721 ttcagttttt tttatactca aatatgctta caagttttca gaattggaaa aaataaaaga 1686781 atatgcggag gtgagaagcg tgaagaagat gagaaaacgt tcttttcatg agctcgtcat 1686841 ggaaaacaaa aaagagctga tgaccaatac agagtattta aatcagcttg aggaaaagct 1686901 tgaacagcga tttaagcaaa aataaccttt aatttgtatt catgtttacc cctccttttg 1686961 agaaacctat ctgttgagga gggataaaca tgggaaacaa caagaaaaac ggtcagcctc 1687021 aatatgctcc aagccacttg ggtacaaagc ctgtaaaata taaagccaat aaaggggaaa 1687081 aaatgcatga tacttcagga cagcggccga ttatcatgca gacaaaaggc gagtagcgaa 1687141 aattcgagtt tatttctagg aggtacatcc gaatgacaaa gaaccaaaat caatatcagc 1687201 agcctaatcc tgatgatcgt tctgacaatg tggaaaaatt gcaggatatg gttcaaaata 1687261 caattgaaaa tatagaagaa gcagaagcat caatggagtt tgcttcagga gaagataaac 1687321 agcgtatcaa agaaaaaaat gcaaggcgcg aacagagcat tgaagcgttt cgtaatgaaa 1687381 tacaggacga atctgcagcg agacaaaacg gataccgttc ttaaaaaacc agggaaacct 1687441 ggtttttttc tttctgattt gattatggta aaatggggct aaattgacgt taagggagca 1687501 gagtaatctt gcatgtatca aaaaaagaaa tagaagtgcg ttatgcagaa acagatcaaa 1687561 tggggattgt ctatcacgca aattatcttg tgtggatgga ggtcggcaga acggccttga 1687621 ttaaggactt aggcttttta tatagtgata tggaaaaaaa aggcgttctg tccccagtcg 1687681 ttgatatcaa tatttcctat aaaaagccgc ttcattacgg agaaaccgcg gttgtacata 1687741 catggataga ggactataac ggatttaaaa ccgtctatgg ttaccacatt tataatccgg 1687801 ccggtgagct ttccatcaaa gccacctcat ctcatatttg tgtggataaa gaaagcttta 1687861 agccaattca attccgcaaa gcttttcctg attggcacac agcatatgaa aaggccaaaa 1687921 aatagggaag tgaacgggat atggcgtttg gtgtgaaacg ggaggaactt aaccggtgga 1687981 aacaagcagt gaaaagagga gaaatcgcat ttttaacaca ttactggctg gatgaccgat 1688041 ttccagaagc aaagaccgtg acaaaagccg gctgtgcaga cattgataag ctggttcagt 1688101 ggggagcggc gtacgggtta aaaaaagaat ggatccataa gaaaagtgaa tttccccact 1688161 ttgatctgct gggggaaaca caaaaatata ttttggaaca agaaaaccta accgatcatc 1688221 ttatacgatt tcatttgtaa aaaaagaacg cacatgaagt gcgttctttt ttattggtat 1688281 tcaaaaaccg gttcatcagc gtcttctgaa tagctgacga gaaggtcgtg gttatcaaag 1688341 taccataaat cactttcttc aataaagaag gtaatgccat cagcttctgc agtgactcca 1688401 gcctcttgtg gggcatcttt cgctacaccg agagaaaaac ccttttgaac gttgctgcag 1688461 cctccatagc ggacgaaaaa gcgaacctgg tctccgcttt ccaaatcgag ttcttcttta 1688521 taccagttca atgcgtcttc gttaattgtc atattcataa cagaacaccc ctttgttctt 1688581 catttgaatt ttctctatta taaacgtatt aggctattct gtgtcaaaag agaagttttt 1688641 taagcttata accattttac tttaggttct gttttattga taattcgttt aatgttcgct 1688701 cggtgtctgt atatcacaaa aatagtgagc agggtaacga caatcaataa atacgtatca 1688761 tggacaaaga aactatatat aacagtatag atccctgtta acatcgatga gagagaaaca 1688821 aatttagtca agtataaaaa gatgaagaat accgcaacca tcgtgataaa taacaggggt 1688881 gcgtaaaata gcaaaacgcc tcctgatgtc gccacggctt taccgccttt aaatttggcg 1688941 aagatgggaa acacgtggcc taaaaccgca aagactcctg caagaagcgg gtgaatatca 1689001 acatgcatga gaaaaggcaa tgcagttgcc agtgtccctt tcaaaatatc tccggctatg 1689061 acgaccgaac cagcttttac acccaatgta cggaatgcat tggtagcgcc taagttgccg 1689121 cttccgtgct cccgaatatc aattcctttg gcaagcttgc ccacaattaa gccagatgga 1689181 atgctgccta tcaagtaggc caaaataatc aataaagcaa ttaacatcta catttctcct 1689241 ttttcaaatt cccttctttt tattttaaca tgagatgtca tgatctgatg ataagttttt 1689301 ttgtaaagtt tgcttacaaa tcaaatcaaa catgcatcat attttgattt ctcctgtttt 1689361 gatcgtgtaa aataagtgaa aaaggagtga cacacgatgc aaaacccttc taaagcggaa 1689421 attaaagaga ttcttcaaag aagcaaacgt atagcggtag tagggctttc agaccgtccg 1689481 gatagaacgt cacatatggt ttcaaaagca atgcaggacg cgggttatga aattatccct 1689541 gtgaacccta caattgatga ggcgctaggt gtcaaagccg tttcatcttt aaaagagata 1689601 gacggtccga ttgacatcgt aaatgtattc cggcgctcag aacagcttcc tggagtggcg 1689661 gaagagtttt tagagacaga tgcgccagta ttttgggcac agcaagggct agttaatgag 1689721 gaagcatacc agatgctaaa agaaaaaggc agaacggtta tcatggatct gtgcataaaa 1689781 gtggcacacg ctgtaacaaa ataggtgcag aactgcaaaa atccttgtaa attcaaggat 1689841 ttttgctttt taattttaag atattgtttg cgtattacgg tgaaacagat acaataaagc 1689901 ttgaacagct ttttttgaat accttgtcca gctgggtttc ggccgttcga tttgcgaagg 1689961 tctgctgctt tatatataat aaacaaacat acgttctcat agtgtaaaaa cagcactagc 1690021 cgatgttttg agaagaactg attcgttagc tctatgttgc gattgcaaac atattggtta 1690081 taatgaggag tccaaggcag tactggctcg aggcgaggtt tataaaaaat atcttatata 1690141 caaatgatgt gtaacactga aaagagaaag acaatgttag tttttgaaag gggtttgtac 1690201 gtttggctag aaaacagcaa tttgattaca acgaagatgc catacaggtg ctcgaaggcc 1690261 ttgaggctgt caggaaaagg ccgggtatgt atattggctc tactgacgcg cggggtttgc 1690321 accacttggt ttatgaaatt gtagataact ctgtcgacga ggtgcttgcc ggccatggag 1690381 atcacataat cgtcaaaata cataaagaca atagtatttc tgtacaggat agaggccgcg 1690441 gcatgccgac cggaatgcat aagctcggca aaccaacccc tgaagtgatt ttaacggtgc 1690501 ttcatgccgg agggaaattc ggccaaggcg gctataagac aagcggcggg ctccacggag 1690561 ttggtgcatc agtcgtgaat gctttatctg aatggctgac ggttaccatt gagcgggacg 1690621 gttttgtcta tcagcagcga tttgaaaatg gaggaaaacc ggttacatct ctcgaaaaga 1690681 tcggcaaaac aaaaaagacg ggaactctta cacactttaa gccagatcca acgatgttca 1690741 gcacaaccac ttataatttt gaaacgctct ctgagcgctt aagagagtct gcgtttttgt 1690801 taaaaggact gaaaattgag ctgattgatg aacgcaatga ccagcgtgag gtcttttatt 1690861 atgaaaacgg catagaagcg tttgttgctt acttaaatga agaaaaagac gtcttgtctg 1690921 aagtggtctc gtttgagggt gagcatcatt ctatagaagt ggactttgcg ttccagttta 1690981 acgatggtta ttctgaaaat attttgtcgt ttgtcaacaa tgtcagaaca aaagacggcg 1691041 ggacgcatga gtcaggtgca aaaactgcga tgacgcgtgc ttttaatgaa tatgcgcgaa 1691101 aagtggcttt gctgaaagaa aaggataaga accttgaagg caccgatata agggaagggc 1691161 tttcagccat tatttctgtc cgcattcctg aggagcttct tcaatttgag ggacaaacaa 1691221 aaggaaagct cggtaccagt gaagcaagat cagcggtgga tgcgattgtt tcagagcagc 1691281 ttgcttactt tttagaggaa aatcgggaca ccgcaacgct tcttgtcaaa aaagcaatca 1691341 aggcgagcca ggcgcgcgaa gcggcacgca aagcccgtga agaagcaaga agcggcaaaa 1691401 aacgaaaaaa atcagaagcg actttaagcg gaaagctgac gcctgcgggt tcaagaaacc 1691461 cggcaaaaaa tgaattgtat ctcgttgagg gagattcagc aggcgggtca gccaagcagg 1691521 gacgagaccg cagattccag gcggttctgc ctttacgcgg taaagtcatt aatacagaaa 1691581 aagctaagct tgctgatatc tttaaaaatg aagagatcaa tacgatcatt catgcgatcg 1691641 gcgggggagt cggggcagat ttctcaatcg atgacatcaa ctacgacaaa atcatcatta 1691701 tgaccgatgc cgatactgac ggcgcccata ttcaagtgct gcttcttacc tttttctatc 1691761 gctatatgaa accgctcatt gagcatggca aggtgttcat tgcgctgcca cctttatata 1691821 aggtcagtaa aggaagcggg aaaaaggaaa tcattgaata tgcatggtct gatgaagaga 1691881 tgggggatgt cctgaaaaaa gtcggcaaag gctataccat tcaacgatat aagggtcttg 1691941 gagagatgaa cgcagaccag ctgtgggaaa cgacgatgaa tccggagtcc cgcacacttg 1692001 ttagggtcaa aattgacgat gcggcacgtg tagagagacg tgtgacgacg ttaatgggag 1692061 acaaagtaga gccgcgcaga aagtggattg agaaaaacgt cgctttcggc ttagatgaag 1692121 aaagcaatat tttagaaaat gaaaacttat cggtcgctga ggaggtttaa tgattgtcac 1692181 agccagaatt atttcatgat ttaccattag aagaggtgat cggcgaccgt tttggacgct 1692241 acagtaaata tattattcaa gacagggcgc tgcccgatgc gagagacgga ttaaagccgg 1692301 tacagcgcag aattctgtat gcaatgcata cagatggaaa cacgtttgat aaaaacttca 1692361 gaaaagcggc caaaacggtc ggtaacgtca tcggtaacta tcatccgcac ggtgacagct 1692421 cggtttatga agcaatggtg cggatgagcc aggattggaa agttcgtaat gtgttaatcg 1692481 aaatgcatgg aaacaatgga agcatcgacg gagatccccc ggcagccatg cgttatacag 1692541 aggcacgatt atctccgata gcatctgagc ttcttcggga tattgacaaa aacacggttg 1692601 aatttgtgcc gaacttcgat gatacaagca aggagcctgt cgtactcccg gcgatgtttc 1692661 ctaacctatt ggtcaacgga tctaccggga tttcagcagg atacgcgacc gacattcccc 1692721 ctcatcatct gggagaagtc attgatgctg tcattaagcg tattcaaatg ccttcttgct 1692781 ctgttgacga actcatggaa gttattaaag ggcctgattt tccgacaggc ggtattattc 1692841 agggcgttga cgggataaga aaagcttacg aaaccggaaa aggaaaaatc attatccgcg 1692901 gaaaggctga aattgaaaca atcagaggcg gacgagaaca aattgtcatt actgaaattc 1692961 catttgaagt aaataaagca aaccttgtaa aaaaaatgga cgagttccgt attgataaaa 1693021 aggttgaagg catctcagag gttcgtgatg aaacggatcg aacagggctg agagtggtca 1693081 ttgaactgaa aaaagaagct gatgccaaag gcattttgaa tttcttatat aaaaatactg 1693141 atttgcagat cacatataac ttcaatatgg tggctatcca taaccgccgt ccgatgctga 1693201 tgagcctgcc gtctattttg gatgcatata tcggacacca aaaggaagtt gtcacaaacc 1693261 ggtccgttta cgagcttcaa aaagcaaaag acagacatca tatcgtagaa gggctcatga 1693321 aagctttgtc tattttggat gaagtgattg caacaatccg ttcttctagc gataaacgtg 1693381 acgctaaaaa caatttgatc gcgaaatatg aatttacaga gcctcaggct gaagccatcg 1693441 tgtcattgca gctatatcgt ttaaccaata ccgatatcac agcgcttaag gaagaggcag 1693501 aagagctcgg taaaaaaatt gaagagctcg aatctattct gagcaatgat aaaaaactgc 1693561 taaaagtgat tacaaacagc ttaaaagcac tgaaaaagaa atatgcagat acgagacgct 1693621 ccgtgattga agaaaaaatt gaagaaatta aaatcaatct cgaagtcatg gttgcatctg 1693681 aggatgtata tgtaaccgtt acgaaggatg gttacctaaa acggacgagc cagcgctcat 1693741 ttgccgcttc caacggtcag gacttcggaa tgaaagatac ggacaggatg ctgcatcagt 1693801 ttgaaatgaa tacgacagac gtgctgctgc tctttacgaa caaaggaagc tacatctatt 1693861 gtcctgttca ccagctgcct gatatcagat ggaaggacat gggccagcat ttttcaaatc 1693921 taatcactat tgaccgtgat gaaacgattg taaaggctat accgataaaa gaatttgatc 1693981 cgtcggcata tcttctattc tttacgaaaa acggtatggt gaaaaagaca gagctcactc 1694041 attataaagc acagcgttat tctaaggcac ttgtagcctt aaatctgaag ggtgaagatg 1694101 aactgattga tgtacatgta acaaatgggg aaagccagat ctttatggcc actcacttag 1694161 ggtatggtct atggtttgga gaagacgaag tgaatgtagt tggcgcgcgt gcggcaggtg 1694221 tcaaagggat taacttaaaa gaggatgact ttgttgtctc cggtgagatt cttcagcaat 1694281 ctgattcaat tgtcttgttc acacagcggg gagcggttaa acgcatgagt ctttctgagt 1694341 tcgagaagac atcccgtgca aaacgcggtg tcgtaatgct aagggaactg aaaaagaatc 1694401 ctcaccgtgt tgtagcactg ttcgcttgcg gtcttgaaca gcgactaatg gcagaaacag 1694461 aaaaaggcga cagaaaagaa ctgcagacaa aagagttgcg gacaaacgac agatacagca 1694521 atggctcttt cttttttgat gaagaggaat caggcaaggt tacagctgtt tggcgccttc 1694581 atacagaaca ataataaaaa acccgctcat actatatgag cgggtttcgt ttgtttttta 1694641 tcagctttca tggttggtga atagatctgt tacagcatga atgacttcaa tcccctgcca 1694701 tacaaataaa ttcagcgctg tgaaagaaaa taagcctaaa atcaccattc ttaagataaa 1694761 caacatgttt aacagcctcc tcatattttc gttacataat cgggtgatgt tgaacatgaa 1694821 gtttgccgaa ataagacgat tgataaaatt tggccagtat aaagcttttt ttccgctgac 1694881 gtctgcggga gtatcccgta cttttgcttt cagcggtcag cagcagaaca gccattgccc 1694941 ataaagcggt cagcgtaaat gcccctgtga tggatttctt ctcatcatca gcattttggc 1695001 cggctttcat ctcatgcatt tcctgctggt cggctacggc tttataatga tggccgatat 1695061 caaaggcgtg gggaattgag aacaaatgaa aactggcaat cgccaagaat aagatggatg 1695121 ctttcaatat cgttactttt ttcaaatgat ctccccctcc tttaatatta ctgaatattt 1695181 ttataataat accccaatcc atcctaaaag taaacctgat ttattaaatt taaaaataaa 1695241 tttaactttg ttaagtatat atctttttgc ttatttttga aagagaaaac ttcttttatt 1695301 agcgtatgta tacccggttt atggtgtgaa taaaaacata ttttaaatga tatgttgttt 1695361 aggatttatt actttattta tgtgtaaatc aaagagaaag gcaagagaat gggaagaaat 1695421 gattacattg ttaatagggt actctttttt taaagccagt ttgcaaggaa tgtttttatt 1695481 cgtaggaaaa taatagagaa ggggtcgaca gagtaacatc tggctatgac aatattcttc 1695541 tcgaaaaaac ttcctaattc gtcatattgt gatataataa aactcgttat gttaaaaaat 1695601 ctaacatcaa aatcgaattc gtattgaatt gatgaaaacg ggaggtaaat atggagtctt 1695661 ttttcaatag tttgattaat attccaagtg atttcatctg gaaataccta ttttatattt 1695721 taatagggct tggattattt tttaccatac gttttggttt tatccaattc cgttatttta 1695781 ttgaaatgtt cagaatagta ggggagaagc cggaaggaaa taaaggtgtt tcatctatgc 1695841 aggcattctt tatttcggcc gcatcccgag tcggcacagg gaatttgact ggtgtagcct 1695901 tagcaattgc gacaggcgga ccaggcgctg tattttggat gtgggtagtg gctgcagtag 1695961 gcatggcttc aagctttgtc gaaagtacat tagcacagct ttataaggta agagacgggg 1696021 aggatttccg cggagggccg gcctactata ttcaaaaggg tcttggtgcc agatggcttg 1696081 gcatcgtttt tgcaatctta attaccgtct cattcggctt gatttttaac gctgttcaaa 1696141 caaatacaat tgctggagca ttggatggcg cattccatgt aaataaaata gttgtagcca 1696201 tagttctggc ggttttaact gcgtttatca ttttcggcgg tttaaaacgt gttgtcgctg 1696261 tttcacagct aattgtgccg gttatggcag gcatttatat tcttatcgct ttatttgttg 1696321 tcatcacgaa tattacggct ttccctggcg ttatcgctac aattgttaaa aatgctttag 1696381 gttttgaaca agtcgtcggc ggcggaatag gcggcatcat cgttatcggt gcgcaacgcg 1696441 gacttttttc aaacgaagca ggaatgggga gcgcaccaaa cgcggctgcg acggctcatg 1696501 tatcccatcc ggcaaagcaa ggctttattc aaacattagg cgtatttttc gatacattta 1696561 tcatatgtac gtccacagca tttattattt tgctgtacag tgtaacgcca aaaggcgacg 1696621 gcatccaagt cacacaggct gctcttaacc atcacattgg aggctgggcg ccgactttca 1696681 tcgcagtcgc aatgttcttg tttgcattca gttcagttgt cggcaactat tattatggcg 1696741 agacaaacat tgaatttatt aaaacaagca aaacatggct gaacatttac cgtatcgctg 1696801 ttattgctat ggttgtgtat ggatctttat caggcttcca aatcgtttgg gatatggcgg 1696861 acctctttat gggtatcatg gcgctgatca acttaattgt gattgcgctg ctgtcaaacg 1696921 ttgcttacaa agtgtataaa gattacgcga aacagcgtaa gcaaggactt gatcctgtgt 1696981 ttaaagcgaa aaacatccca gggctgaaaa acgctgaaac atgggaagat gagaaacaag 1697041 aagcataata taaatataaa acaaagctgc attcaatagt tgaatgcagc tttttcatta 1697101 ttggaaataa atttaatttt tcgactcgaa tgaaaaatga cgtgtaaagt cccaattcag 1697161 tccagttttc tttgttctat atgtgtcatg tgtgtcttat tcattggagg tagagcaaat 1697221 tgacaggctt ttaaacctcc ccaaaacaag aaattaggtt gatagacaat catgagaaag 1697281 atttttacaa tgagttcgtg ctcataagaa gtgtagagcc aaaatgatgc gaaggaggaa 1697341 aagatcagat atgaaacggt caatctctat ttttattacg tgtttattga ttacgttatt 1697401 gacaatgggc ggcatgatag cttcgccggc atcagcagca gggacaaaaa cgccagtagc 1697461 caagaatggc cagcttagca taaaaggtac acagctcgtt aaccgagacg gtaaagcggt 1697521 acagctgaag gggatcagtt cacacggatt gcaatggtat ggagaatatg tcaataaaga 1697581 cagcttaaaa tggctgagag atgattgggg tatcaccgtt ttccgtgcag cgatgtatac 1697641 ggcagatggc ggttatattg acaacccgtc cgtgaaaaat aaagtaaaag aagcggttga 1697701 agcggcaaaa gagcttggga tatatgtcat cattgactgg catatcttaa atgacggtaa 1697761 tccaaaccaa aataaagaga aggcaaaaga attcttcaag gaaatgtcaa gcctttacgg 1697821 aaacacgcca aacgtcattt atgaaattgc aaacgaacca aacggtgatg tgaactggaa 1697881 gcgtgatatt aaaccatatg cggaagaagt gatttcagtt atccgcaaaa atgatccaga 1697941 caacatcatc attgtcggaa ccggtacatg gagccaggat gtgaatgatg ctgccgatga 1698001 ccagctaaaa gatgcaaacg ttatgtacgc acttcatttt tatgccggca cacacggcca 1698061 atttttacgg gataaagcaa actatgcact cagcaaagga gcacctattt ttgtgacaga 1698121 gtggggaaca agcgacgcgt ctggcaatgg cggtgtattc cttgatcaat cgagggaatg 1698181 gctgaaatat ctcgacagca agaccattag ctgggtgaac tggaatcttt ctgataagca 1698241 ggaatcatcc tcagctttaa agccgggggc atctaaaaca ggcggctggc ggttgtcaga 1698301 tttatctgct tcaggaacat tcgttagaga aaacattctc ggcaccaaag attcgacgaa 1698361 ggacattcct gaaacgccat caaaagataa acccacacag gaaaatggta tttctgtaca 1698421 gtacagagca ggggatggga gtatgaacag caaccaaatc cgtccgcagc ttcaaataaa 1698481 aaataacggc aataccacgg ttgatttaaa agatgtcact gcccgttact ggtataaagc 1698541 gaaaaacaaa ggccaaaact ttgactgtga ctacgcgcag attggatgcg gcaatgtgac 1698601 acacaagttt gtgacgttgc ataaaccaaa gcaaggtgca gatacctatc tggaacttgg 1698661 atttaaaaac ggaacgttgg caccgggagc aagcacaggg aatattcagc tccgtcttca 1698721 caatgatgac tggagcaatt atgcacaaag cggcgattat tcctttttca aatcaaatac 1698781 gtttaaaaca acgaaaaaaa tcacattata tgatcaagga aaactgattt ggggaacaga 1698841 accaaattag ttaagctttt ttttggcgga catcagtaac gatgtccgtt tttatcatct 1698901 aataggaggt ttgcgttgtg gatgaaatac tgaaacagta tatggtgctg tataaaaaaa 1698961 tgagtaatat gataaatggt cccgactatc caggtaagga aaaagacatc cagcatcaaa 1699021 aagatcagat cgaagtttac gaaaaacagc tgcagcaagg attttctaca gattatgact 1699081 atgatgtgtt tgctgattct gttatcaaat gcgcatatgg cgatatgacg ctggaagatt 1699141 tagaagccgt ttattatgga ttgacaacac catttttttg atttgtcatt cagcagtaaa 1699201 atttcaattt ctgtctcact aacttaagta tactttgata ttgagacaga aatttattta 1699261 ttttgtttac ttcctagaat atatattatg taaactagaa aagatgaaga ataaagcttt 1699321 gctgttttta tgtacatcct ttcttcttcc tgtaattcag caacaaaata aaaaagcgat 1699381 ttcccaatcg gaaaatcgcc aattcagaca ctctattatt tatgtgtgtc tttgtgctct 1699441 taacgattta caacaaatgt tgtcacgctt tgagctggaa gatgagccca aaaatgattg 1699501 cctgatacag tgagattcgt tccaggttgt agattgctgc tgctgctcgt gatccatcta 1699561 gatacgtttg aagcagatcc attctgcaaa acaaagtttt ggttgactcc tgtgttgctt 1699621 ttattgatgg caacaataac gaccttgttg tcacctttat aggctgacac gtaaacgttc 1699681 gcattagggt ttttcgttgc atcaatcctt acatagccgg gacgcacaaa ctttgagaaa 1699741 tgagccatat tgtagccgcg tttgctgatc gtaccatctt ctttcatagg tccatatgat 1699801 cttcggatgt accaccatac ataagcttga aagtccccct ctaccatcgc attgtgaata 1699861 tgctgtgaaa catccaatgc ctcaggccat cgatccgccg agttggtatc actgtttgga 1699921 tagtatactt ccgtcatcca aaggtccttc cccgctcctt tttgtttgaa aagaggataa 1699981 gggaattggc tgacctgggt gccgtacagg tgagttccga gaatatccat attggcaaga 1700041 gcctgcggat cgttcaagat cgggtccgac aaattcttca agtattgaaa tgactcaggc 1700101 gcaatgacgc gggcattgat cgagccggcg ttttctctca taaagcgaag tatttcttgc 1700161 ggcgtccacc acgtccactc gtgagcgtaa tcaggctcgt tttggaccga aatcgcgtaa 1700221 agattcacac cattattctt catgaaggta acaaaatcgt taagatgctg cgcgtatgct 1700281 gcgtacttgt tgtatttcag ccgtttagcc gatgtgtcac cattccgatt aaaggtctca 1700341 accatatcac ttggaggatt ccaaggagaa gcaaaaacga ttgctccgtg tttgaccgca 1700401 ctctttgcag tctccacctc tttataccaa ttatttcgat tttcatctac atgaattctt 1700461 aagattgaaa atcctaactg gttctgtcca ttgccaaaag cagtttctct ttgagctgct 1700521 gtaagatccc cagcccaagc cggatgattc atccctccaa aaccgcgaat cacttgtttc 1700581 tctgcagata cattaactgt tacatcactt gctgccaaaa cttcagtagc gcctggccct 1700641 aacatgactg acagcatagt gaaacatact aatagtacac aaattgtttt ttttatgcgt 1700701 ggaatcattt attcctctcc ttcgtcatgt gtcttttacg gtattaaaaa atctgcatgg 1700761 catatccata atggcgggct gttccggtgc tggcccgtac ttcacccgcc tcgtttttaa 1700821 gcggtcccat tacgagtact atctttgcgt aaactgccag taatcaaaat taaacaagtt 1700881 tcctgtacct gttccggtaa atacaaagaa tactttgtgc acaccggttg ccccgcttac 1700941 cgcagtttct atttccctcc acgtttgcgc tccgcctgtt gaaggcacat tcagagttcc 1701001 aacaagctta ccgtctgcac tgtcgaggcg cacttctatt ttcccgccta aagtggatgc 1701061 tacatttgct ttaaatgacc tggcaccgcc cgctccgaag tctgcatttc ctacagcaat 1701121 ccagtctcca ttttgaatgc ttgttacatg ctgattattt actggcccgc cgggtgctgt 1701181 ggacttctct gtcaaaatgc gtccattcca agcaaacgtt tcagcttcta cccggttata 1701241 tgggtttaaa ttggaaattt gtgttacacc tgcataattt gccgctacct cttgaataga 1701301 tccatctgca ttatgcacca gcttattaat atggggagag cggtatcctt tgccggcccc 1701361 gaacagagcg gaactgacag tttgcgcatg gtacaccaca taccactcgt ttttaaaatt 1701421 gaaaacagca tgatggttgt ttccgccacc tccgaaaaat gcacccggat ttttcaggaa 1701481 gtgccctcta tatgtaaagg gacccatggg acttgaactg gtcatgtagc cgatctcacc 1701541 cgggggttta tcggccgggt gcgtgccgcc gaaattgatg caataggagt aataatatgt 1701601 tccgttatac ttgtgcaatc ccgaatcttc aaacatgaaa ggcgcatcaa ttgtagatgc 1701661 acttccaaca acactcgtca tatcaggccc caattttatg actctagccg ttttaggatt 1701721 ggcccattgt ccctgcgttg gatttgaaac gccaggaacg cctccgccgg catacaggta 1701781 accggttccg tcgtcatcta caaatactgc cggatcaaaa agccatacaa caccagacat 1701841 tcctggcgta cttggcgtta cgagcggttt tccgattggg tcggtccatg gaccaatcgg 1701901 gctgtctgcg gtgagaaccc cgatacctcc gccgctgttt gcgaaataaa ggaagaattt 1701961 atccttgcca ttaatttttt taactgcgat tgacggtgcc catgacgcac ctgcccattt 1702021 tgcaattcca cggcctccat tagctccatt ggcacctgct accggaatgg ctccgtggtc 1702081 tgtccagttc accatatccg ctgaagatat gacgaatact ctattcaaat tggcaaatga 1702141 attatcttta attgttccgt tgctattata ttcatagtca tcacttgaca tatagatgta 1702201 gactcttccg ttataggtca gcgcaaccgg atccgctccc aaatgatggt cgataagcgg 1702261 atttgaattc cctatatgtt ttgcaattgt agtactagtg gcagcatacg cagacttccc 1702321 agataagcag ctcaataata aaactagaat ccataaacat acgctacact ttttcctcat 1702381 cacttcacat cctccttttt ccttaaaatg ggggattttc ttttggaatt tgataacaac 1702441 aggtcacgaa gattgcacgc ataaagtagc cggaagctgt ttagcaatgt tcccagttgt 1702501 tctgaaagct catcttcatg tgtctccatt ctctcttttc ttcgaggaga tcgcaccact 1702561 ccttcaaaat tgttcaaaaa aacttcccca ttcctagcga ccattgtcca gaaaataaaa 1702621 agacaggatt gttcatggcc tcccactaat cacattgaac ggagattaca tcattatcca 1702681 agatatccct ttatctaaca tcctacatca ttaaaaaaat tgtgtataga aacttttgga 1702741 ggagttagtg ttcgattcta caaaggaact ggatacattt attcattgat aagatggggc 1702801 taacactccg tttatatttg tatgttttca gacacaaaaa acagccgttc aatgcggctg 1702861 tttttttcaa gagtataaga ctattgagcg gtatacccgc tttttcatgt tttgttcata 1702921 ttttattaat tgtttattca acactgtccg ctatagtaat ccatatcaac aaatatgact 1702981 gccactcgca tcttttatga agggaggttc gttacgctga aagaaaaaat aaagacatta 1703041 ggccgttttt gcaccgtagg cgtcggcaat acgctgatag attttggtgt cttctttctt 1703101 cttaccgctt gtcatgtctc ttatctgccg gcgcagatct gctcctatac tgcaggtatc 1703161 gtcaacagct atgtgtggaa ccggaattgg acgttttgtg tgaaacgtaa ggctgacggg 1703221 aaagagatcg tgcgttttct catgattaat attgccgcgt cagggatcac ctttttgctg 1703281 ctttatttgt ttcaaaattg cggctgctcg cttttggtga gtaagctcgc cgccactatc 1703341 ggcggaatga tgatgaattt tatcggaaac cgaatctggg tatttggaga ttcgctgaaa 1703401 aacatacagg atcaggagtg aagatgaatg agaaaaaaag tgagaaaagc ggttataccc 1703461 gcagcgggtt taggaacgag atttctgccg gcgacaaagg cgcagcctaa agaaatgctt 1703521 ccaatcgtcg acaaaccagc aatccaatat attgtagaag aggccgcaga gtcaggaatt 1703581 gaagatatac tgattattac agggagaaac aaacgctcga ttgaagatca ttttgatcgg 1703641 tcggcggaat tggaattcaa tctccgggaa aaaggcaaga cggagacact taaggaaatg 1703701 cagcagattg ccgatttggc caacattcat tacatccgcc agaaagaacc gctcggatta 1703761 ggccatgcgg tgctgtgtgc ggagcatttt atcggagatg agccttttgc tgttctctta 1703821 ggtgatgata ttatggtgtc tgaaacaccg gctcttcggc aattaatgga tgtatatgac 1703881 gtttatggca cagaggttgt cggtgtacag tcagttctcc ctgaggatgt cagcaaatat 1703941 ggtattataa atacatcagg gtctcaaggg catgtatatg aagtgaacga tttagtggaa 1704001 aagccttctc ctgaagaagc accttcggaa atcgcagtaa tgggacgtta tgtgctgaat 1704061 tcttcgatct tctccgtttt gaagacaatt ggcagaggcg cgggcaacga aattcagctg 1704121 acagatgcgc ttcgtgaggt ttgccgtaag gagccgatcc atgcccggct gctggaagga 1704181 aatcgatatg acattggcga taagctgggc tgttttaaag cgagcaccga aatcggctta 1704241 atgcgtcccg aaatgagatc tcagcttttg gcctatttag aagatgtgat caaacgggaa 1704301 acgaaagaaa tgctgcggta aaaaaattgt aaccatcttg ctcgtcaatc agtcatataa 1704361 tagtgaaaaa gattaggaca ggttgtgaag aatgtgggca gtttgataag cgaaatttta 1704421 acatggctga cgaacatggg atatgcgggt attgcgattg ggttaatgat tgaaatcatt 1704481 ccgagtgaga ttgtattagc ttatggcggc tatatggtat cggagggcac gattggattt 1704541 attggcgcaa ttattgcggg tgttatcggg ggcaccattg cccagatctt tatttactgg 1704601 atcggtcgct atggcggcag gccatttctg gacaaatacg ggaagtattt attgattaaa 1704661 aagcatcata tcgatatgtc ggaaaactgg tttcagaaat acggcgccgg agttgtcttc 1704721 tcggctcgtt ttataccggt tgtcagacat gccatatcca ttccggcagg tattgccaga 1704781 atgccttttc tcaaatttgt ggtactgact gtgcttgcta tcattccatg gtctatcctg 1704841 tttgtttatt taggcataca gctaggaagc cagtgggatg atgttgagaa tatagcaggc 1704901 acttatacaa caccgattat gatattggct gttgtcgtga tagcccttta ttttgtgatt 1704961 aagaaacgta cagccatatt taaacgatag ctagcggata tgcatagggg tgactgacgc 1705021 tcccctatgc atattttttt acttgcgatg ttgatttgcc agcttcagat tctccgctaa 1705081 aaatgcgaca aacacttcat cccgcacgag cgatgcggca taatttctct taataaacca 1705141 ttctgcctct tcaaacgctg cgaatgtttc gtcttgggtt tctccgttaa tttgaatatt 1705201 ccattcgttg tctaaaggga aaagaaaaaa tctcatttgt gcgcgatttt catataatga 1705261 tccattcgca gatcccttta gattatagat gttacggaag gcatccggcc gtacaggatc 1705321 aatacggaaa gcttcagcta caaacaactc gtatacttca tcggttattg aacagccgga 1705381 cgcttttgca tgccctccgc cgccatatcg gccggcgatt tctgacacat cgatgtaatc 1705441 atgaatggtg cggagactga ctcgttttga ccccatgctc aaaatcgcaa tgtaatcgag 1705501 gtgcgggtta tctttcccta gcctgttccc cagctctgaa tggtacgatt cagcgtgaac 1705561 gatgcctaca cagtgttcgt gaacaaaggt ttgtaccatt tcccttttct ttctgcggag 1705621 gtagcgctcg attttttcgt cttctaaatc aagcagtttt tcttcaaaat catcgaagaa 1705681 aaattcgtca tgcgtggaaa ggcgctggat catttttgct tcaaattcat cgattgacag 1705741 caaaaagaaa agatcattaa gccgcttcgc ctgtttttga tcgtaccgct cccactccca 1705801 tgtatcgtat tggcggacga gctctgtgaa ttgatctaag gcgtttgtcg gtttcatgaa 1705861 gccattttca atgagatagc catataaaag cgatgtcgcg gatgtgagcc ttccatcatc 1705921 gtattccacc tggacaaatc cccattcatg ctcattcaaa tgaagggctg ttttatgatg 1705981 gtcaatgagc ttcactttgc cccctgcatg aacatactca ttcaatctct cttcgttttc 1706041 ttcattgacg gcgagatcgg tgatgaataa cgcgtcctgt ctgttgctct ccttcgcttt 1706101 ttctaaaaag tactgcacct gtgcgtttaa gccgttgaca gagttatacc ggatctctac 1706161 gtcttttccg aacgccaatt ttgctacgat tccgcatcct actccgtcca agtcgttatg 1706221 tgaatataaa tgatacataa tgtaggcccc tttttatgat aaactgacaa ttgccgctag 1706281 aggtgcggca gcctttattt actattctaa aaaaccaagc gttttatgca atggtaatta 1706341 gttgacataa tgttgttatt gtaaatatat aaaggagcgc tttttttgcg ctcctaagtt 1706401 cttgctttta caccggataa accggatgct ttcgattggt aaatgtcatt tcctttgtca 1706461 tgtatgcctt gagccgtttg gccagctcat cacgcagcga attggctggg ataacagcat 1706521 caatgatcat ttctgaagcc agacggtaga tattgatgtc ctctttgtat tcctcccgtt 1706581 tgctgctgat aaatgcggct ctctcttctt ctggcagctc ggcgattttt ttagcgtaga 1706641 cagcgtttac agcggcctca gggcccatga cggcgatttg ggcggttggg agcgctagac 1706701 agcaatccgg ttcaaatgcc ggccctgcca ttgcatacaa ccccgccccg taagcttttc 1706761 ggacaatgac agagagtttt ggaacagttg cctccgacat cgcagaaatc attttcgctc 1706821 cgtgtctgat aatcccagcc tgttctactt ttgtgccaat cataaaaccg gggatatcgg 1706881 ctaagaacag caatgggata tgaaaagcgt cacataaggt aataaactta gccgctttgt 1706941 ctgctgaatc gtggaataag acgcctcctt ttaccttcgg ctggtttgca acaatgccga 1707001 caggctgtcc gtggattcgt gcgaggcccg tcaataattc cggtgcaaat aaggctttga 1707061 tctcaaaaaa tgagtcttca tctatgaccc gctcaatgag ctcatgcata tcaaaaggtg 1707121 cgttttgatt ttgcggaatg acgtcggcaa gcggagtttc gaagtgtttt ggcgggcgtt 1707181 tctcatgaat gggcgctttt tcttgaaaat ttgccggaaa gtaagacaaa taagcccgca 1707241 ccagctgtat ggcttcttct tcagtttctg caagaatatc tccgcagccg gagattgagc 1707301 aatgcatacg ggcgccaccc atttcttcga gagacacttt ttctccaata accatttccg 1707361 ccatccttgg cgaacctaaa tacatggagg cgttaccgtc taccataacg acgatatcac 1707421 agaaggccgg aatataagcg cctcctgccg cagatggtcc gaaaagcaga cagatttgcg 1707481 gaatgcgtcc cgataatttg acttgattgt aaaaaattct tcctgcaccg cgtctccctg 1707541 gaaagacatt gatttggtcg gtaattcggg cgcctgccga atcgactaaa taaatgagcg 1707601 gacagtttaa tttttcggcg atttcttgaa ttctgatgat tttttcaact gtttttgctc 1707661 cccatgaccc cgctttcact gttgaatcat tcgccatgac gcaaacggtt tggccgccga 1707721 ttttgccgat agcggttaca actccgtcag cgggaagccc gtctgacata cattccgcaa 1707781 aaaaagcgtc ttctagctca atgtcatcgt caaagagaag ggaaagccgc tctctgacaa 1707841 agagcttgcc tttttcccga ttgctttgat gatacttttc cgctccgcct tttcgaatcc 1707901 gttcagcccg ttctgttcgt tccttttcat aatccatcag cattgcctcc cttttatatt 1707961 cccttgtata cggcccgtct tttttcttga aaggcctgaa gcccttctct cctgtctttt 1708021 gtcgggatgg tttgttcata cgctttttgt tcaatcgcaa ggcctgtagc aagatctgtc 1708081 tccaatcctt tattgattgc aaatttagcc tgacggacag cgatcggtcc gttggcagaa 1708141 atggctgcgg ccagttcctc tgcttttggc ataaggtcac aaggagccgt gacatgctct 1708201 acaaggccga tttcttttgc ttcgtgtgcg gtcacgcgtc tgcctgtata aatgaattct 1708261 tttgcttttc ctctgccaat cagccggggc agcctttggg tccctccagc gcccgggata 1708321 atagctaacc ctgtttccgg aagtcccagc acagctgctt cagttgcgat tcgaaggtcg 1708381 catgccaatg ccaattctag tccgccgcct aatgcgcttc catttatcgc agctatgacc 1708441 ggctgcggca aggcatcaag taaagccgcc gttctttgaa tgagagatac actttccaga 1708501 acctgatctt ctttcagttt tatccgttcc ttcaggtctg cccctgcaca aaacgctttt 1708561 tcaccggtgc ctgtgaggat gacgcaacgg atgtttgagt taaattcaat ttcctggata 1708621 atcatttgca ggtttctaag catttccgct gaaagagcat ttgctgcctg aggcctgttt 1708681 aaggtgatca acgccatatg ttcattttta acagtaaaaa gaatagaatc tcccattgta 1708741 tgcgtcctcc cttttatcaa gatgatttaa acacctgtaa atttctgctc ggcagcggtt 1708801 tgcccatttt ttcttcaatc catttggccg cagatagcag tttttctagc tttacatttg 1708861 ttttgatatc catctgttca agcatgtaca cgatatcctc agttgcggcg tttcctgatg 1708921 aacctggcgc atatgggcat cccccaagcc cgcctgccga gccgtcgaac accgtgatgc 1708981 ccatttggag tgctgtgacc atgttggcca gagcggttcc tctcgtatca tgaaaatgca 1709041 gggcaatttg attagccggg aatcgtgcca aaagagcttc aagtacagtt tccacttggg 1709101 cgggattagc tgctccaatc gtatctccaa gcgacagttc agaaatccca aattcaaata 1709161 gagcttctga aaggcgaatg acttgttcaa tggggacatc tttttcgtac ggacagccga 1709221 aaacagtcga gaggtaggct cttgttgtga ggtttgcttt ttgtgcgtcg ttgtttactt 1709281 gtttgagtat atggagggat tcagaagtgg atttattgat gttttttctg ttgtgcgtct 1709341 cgctggcgga cataaaaacg caagcctcgt taatgcctcc ttcaagtgca ttctccagtc 1709401 ctctttgatt cgggacaagt gccgcgtacg ttaccccttt ttctcggtcg atgccttttg 1709461 ctacatcgat agcatctcga agcgccggaa tccatttcgg gtgaacgaag gatgtgattt 1709521 caatatacga cagccctgtc cgggaaagct ggttgatcca ggttatttta tcctctgttg 1709581 cgatccaaac gggctcgttt tgtaagccat cacgcgggcc gacttctttg attgtcactt 1709641 ttttaggata tggcatggtc ttcctccaaa ttattgagtg gaattgctca gttcgagcag 1709701 tacgtctcct tcatttacaa agtcgccttc cttttttttg acttctttta cgattccgct 1709761 tctatctgca acgatcggga tttccatttt catcgattcc aaaatggcta cctcctggcc 1709821 cttttcgatt tggtcgccgg ctttgacgtg gactttccac aggtttcctg ccatttgtat 1709881 gctaaccgtc atgacaactg cctcctttat aggtgctgtt tcaaaaagtc agtcgtgaca 1709941 tccccttctt taaatgcctt tgttgccgca gcctgtatga ggagcggaag gtttgttttg 1710001 attccctcta cacgatagtc gcgaagcgct gtctctagtt tttcaattgc ttctgttctg 1710061 gtttggcctt tgacaatcat cttagcgatc atcgggtcat aaaaaggggt aacggtgctg 1710121 tcttttgcta ccgcacattc gtgtctgact cctttttggt caggaagtga aaacgcagtg 1710181 atcgtacctg gtgacgggaa gaaggtcttg ggatcttccg cgtatattcg aacctctatc 1710241 gcatgcccgt tccgttggat gtctttttgg gagaatgtga gtgtatggcc cgcagcaatc 1710301 cgcagctgct gctcaactaa gtccaggcct gttatttctt cagtcacggg gtgttcaact 1710361 tgcagtctcg tattcatttc gaggaaataa aaattttgtt tctggtcaac tataaattcg 1710421 atggtgcctg cgttcgtata gccgattgcc ttcgctgctt ttaccgctgt ttgaccgatc 1710481 ttcattctta gttcatcgtc tacaaatgga gacggtgctt cttcaatgac tttttggtgg 1710541 cgcctctgaa cagagcaatc acgttcaaac agatgtactg tatggccgtg ttgatcggcc 1710601 aaaagctgaa cctcgatgtg gcgcgcatgt tcaataactt tttctatata catagacccg 1710661 tcaccgaaaa aatctgctgc gcgctttttg tttccctcgt acgctttttt taatgcttct 1710721 tcattttcaa cacgctgcat tccgatgccg cctccgcccg ctgaagcttt cagcatgaca 1710781 ggatagccga tttgacttgc ggtgcggcag gctgcctcta tatctccgag ggattcagaa 1710841 acgcccggca ccacagggac acctgcagcc tccattgctt ttcgcgcttc aattttgctg 1710901 cccatctttg cgatgatatc aggggaaggt ccgataaaca cgatgttttc ttgcttgcag 1710961 cgttcagcga accggctgtt ttctgataac aatccatatc ccgggtggat cgcgtcggct 1711021 tttgcttttt tcgccgtctt tatgattctc tctatattta aataactttc actgactctc 1711081 gattccccga tcaaatatgc ctctgtagcg gcttttgtat ggggcgcgtc cttgtctgct 1711141 tctgaataaa cagcgaccgt tttaatgccg agacggctgc atgttcggat aattctcatt 1711201 gcaatttcac cgcggttggc gatcagtact tttgtaaaca tgatttcacc tcattgactt 1711261 gatgataagt tgaacatttc aatcgttttt tctcgcagtt tatatttttg aattttgcct 1711321 gaggccgtca tcggatagtc atccgtaaaa ataacataac gcggaatttt gtggcgggcg 1711381 attttccctt tgcaataggc tttaagctca tcaggtgaaa cgcttttacc gtctttcagt 1711441 ttaatccagg ctgcagcttc ctccccgaat ttggcgtcag gcacaccaac cacctgtaca 1711501 tctaaaacag cgggatgctg gtataaaaat tcttcaattt cccgcggata aatgttctcg 1711561 ccgcctctga tgagcatatc ttttaatctt ccggtgatgc ggcagtaccc gtcttcatcc 1711621 atgacagcaa gatctccggt aaacagccat ccgtcatgat tgattgcttt tctggtcgca 1711681 tctttgtctt tataatagcc tttcatgacg tgatagccac gggtgcacag ttctccctgc 1711741 atgcctcttt gaacttcttg acatgtcccg ggttctacaa ttttcacctc agtatgtggc 1711801 agggcacggc cggttgtttc gactcttctt atgaaggaat catttgctct cgtttgtgta 1711861 atgactggcg aggcttcggt ttgtccatag gcgatcgtaa tgtctttcat gcccatcctt 1711921 tcaatcacag ctttcatcac ttcacttgga cagggagagc cggccatgat tcctgttcgg 1711981 agcgtcgata gatcatatgc atcaaaatcc ggatgatgca gctcggcgat aaacatggta 1712041 ggcacaccat ggagcactgt gcatttctct ttttctaccg ttttaaggac ggtaacggga 1712101 tcaaattctt gcacgggtat catggctgcc ccgacggata cacatgccaa aaccccaagg 1712161 acgcatccaa agcagtgaaa aaacggaaca gggatgcaca tgcggtcttg agaggttaaa 1712221 gccatacatt cagcgatatt agcagcgtta ttgatgacat tgaaatgggt cagcatcacg 1712281 ccttttggaa accctgtcgt tcctgatgtg tattgcatat taatcacatt gtctttatcc 1712341 aggctgttca ttctctcttc aagctcagca tctgtcactg ttttcgccaa tatctctgta 1712401 tcgtcccaat gatacatgcc agacaatcgt ttattgccaa tatagatcag cgtttttaaa 1712461 aagggatagc gttcagattt cagttggccg ggctttgctt cttgcagttc tggaattaaa 1712521 ctgttcacga tgtctggata agaagtgccc ctgtatgaat ccatgataat aagcgccgcg 1712581 gcatccgatt gctttaacaa gtaatcaagc tcatgtgctt gataattggt attgacggtc 1712641 acgagcacgg ctccgatctt cgcagttgcg aactggacgg caagccattc agagatatta 1712701 gaagcccata tggcgacgtg gtctcctttt ccaatcccca tccgcatgag acctttagcg 1712761 gtttgacggc acagactgtc aaattgagcg tacgtatagc ggatatttcg gtctggatac 1712821 acaacagcat ctcgatcggg atacgcatca gctgtttgtt ccagcagcct gccgattgtg 1712881 gaatggatga gttcagccat tcattgttcc tcctttctta atgataggaa agcgtttaca 1712941 tttttatttt aaaagctgtc tggcgatcac gagacgctga atttcagatg tgccttcacc 1713001 gatttccatt aattttgcgt cccgcagcat ccgttccacc ccatactctt tcatatagcc 1713061 tgaacctcca tggatttgaa tggcttgatt gcaagctctt gtcgccattt cagatgcgaa 1713121 tagcttggcg tacgccgctt ctttggtgaa cgggcggtta tgatctttca gccaggcggc 1713181 ttttaacacc atttgccgtg ccagatcaat ttccatcgcc atgtcagcaa gcttaaattg 1713241 aatcgcttga aaggaagaaa tcggctgtcc aaactgcttt cgctctttcg catatgccaa 1713301 tgatgcgtca agggccgctt gggcaatgcc gactgcaaga gcagcgatgg agattcgacc 1713361 accatccagc gtatatagaa actgtttaaa cccttttgtt ggatcgccaa gtaagttggc 1713421 cgcaggcact cttacatctt caagcaagat ttccgctgta ttcgaaccgc ggacgcccat 1713481 tttatcgtac gggctcgtaa tcgtaagtcc tggtgtgtca gttggcacga ttaatgcgga 1713541 gatgatgttt tttccgtctt tgtttttgcc tgttacggcg gttacaataa ctgtgcgtgc 1713601 gtagcttgca ttagtgatcc agcacttttc gccgttgatt acatactcgt caccatttga 1713661 aatcgctttt gtttgagtgc ctcctgcatc tgagccggca tttggctccg tcaggccgaa 1713721 tgatccgagt gctgtgcctg aagccagcgg cgtcaaatgc gtctgttttt gctcttctgt 1713781 tccgaagtag taaagagggc ttgcgcctag cgagaccgct gcagcatagc ttaatccagt 1713841 actgccgcag gctttgccga cttcttcaac cgctaaggca tatgaaatcg tatcaccgcc 1713901 agatccgccg tattcttctg gaaatggaat acccatcaga ccgagttcac ccattttttt 1713961 aaatgtttgc atcgggaact cgcctgtttg atctacatgt tcagcgtgag gagcaatttc 1714021 ttttttcgca aaatctttta ccatttcacg caccatttgt tgttcttttg tcagctcaaa 1714081 attcacatcg tttcctcctt cacatctttg taacatccta ttaggcgagt tctataatca 1714141 ttccctgaca agaaaagtct gaaaattaaa actgaatcat tttttatgtg ataatatcag 1714201 cgggatgagc aaatacatgc agtaggcgca taccatccat atcgtaaacg caataacttg 1714261 gccctttgat aaagccggga agatgagggg aagattccaa agggaaatcg tatccatcaa 1714321 taaaccgacc gctgatcccc atatacctag cttgatcacc gcgaactgtg attgatcgag 1714381 tttttgatag agaaagaaca caaggcataa aacaagagca gtgcccgctc ccaagagaag 1714441 aaagttcggc aaaaaggctt cttcagccgg atcagtcaac acagcatctc cgaacagcac 1714501 aaaaaataat gtggcaccta accagactag aaatgaaaac gtaaaacacg tcctgtacgt 1714561 gtttctcttc gattttattt ttatttagta ctagtttctc agattccaat aatggtaaat 1714621 gtccaaacac cgcctccata ttcatgtgaa tctcaccttt gttttttaaa aaattcagcg 1714681 gtttaccatc gtttcctgtc ccaaaatcac tttttaaaaa aagacgactt agaaagccgt 1714741 ccttctcatt tcttattttg ttgttcgttt ggaagctttg ctttcgttat gaagccggtc 1714801 tgctgaagtg acataatacg tatatttctt gttgggatct gccgtgttat ctaagaaggt 1714861 ttgctgctca tgtgtttttc tttgcgttgc cagcaatgtt ctctgctttt tcccttcggc 1714921 tctgtatatc gcataatagg ctgtttcttt cgttttttga tttgatgggt gatctttaat 1714981 ctgcagaaga ttgccgtttt tgtcttcggt gactttcgta agcttcggtt tttttggggc 1715041 ggtattgtca agccaaggca tttgcggaac cagtgccggc ttgctgtaaa gatcggtgct 1715101 gagactgtct ttgatgccaa gcggattttt gttgaggtcc ttgaggctga aatgcatgct 1715161 tcctttcacc agttcaagct ggcggttcaa agtgatttgc cgcacatatt cctcaggatc 1715221 ggaccaaggc ggatcaaaat tgttattgat tttatatgct gcctggccaa tatataagtg 1715281 aacaggccta tttttgactt cattgctcca ccaatcagcc agcacgtcgt aagccgctgc 1715341 gttaaagccg atactccaat aaatttgcgg agcaatataa tcgatgtcgc cttcttggat 1715401 ccaatgcctt gtgtctgcat atagatcgtc ataatttctg acgcctgctt ttgtattcga 1715461 tccggtcggg tcatctgcgg cgtttctcca tactccaaag ggactgatgc cgaatttgac 1715521 atacggtttt gcagctttaa ttgtttggtt gatttgtttg acaagctggt tcacattgtc 1715581 ccgccgccag tcatcgatat tagaaaaagc gtcttttccg tattgttcgt actgtgcttg 1715641 atcaggaaat tcctgtcccg ctattttata agggtaaaaa taatcatcca tatgaacagc 1715701 atcgatatca taatgtttta cgacttcttc aatgcctttg acgataaaat ctctcgcttc 1715761 tggaatgcct ggatgataat acagctggtt tccataggcg gcaacccaat ctggatgttt 1715821 tcttgccggg tgatcctcag acaatttatt aagatctgta tgattcattg taatacggta 1715881 aggattaaac cacgcgtgaa attccaaatt tcgtttatgg gtttcttcaa tcataaatgc 1715941 aagaggatca tagccggggt ccttcccttg gacaccggtt aagtattccg accaaggccc 1716001 gtaagctgac ggataaaagg catcagccgt cggtttaatc tgaacgataa cggcattcat 1716061 tcccattttt tgcacatcgt ccagcagttt gatatactcc tgtttttgct ctttcacaga 1716121 taaccctttt ttggacggcc aatcaatatt taatacggaa gcaatccata cggctctcag 1716181 ctccctgtca gactgcgcat tggccataaa cggaacggaa atgacaaacg ttccgatgat 1716241 caagctgaca aggaaacgga caatcgactt ttggcaaacc ttcattctgt ttcttctccc 1716301 ccattacatc actttcacta ttcgctatta cggtattccc gggctataaa agggtgatta 1716361 acagaatgtc tatctcacta aataaacgaa aaaagtccta aagcatgttg tgaaccgctt 1716421 ttaggacttt ttatcattca tcatggtttg cagacttttt aacacatcaa taagttttac 1716481 gccgacaccg acagccgttt caaggatcgc ttgtgctccg gcaatggcta aaataaagat 1716541 cagcggtatt gcaatacgag gcaaaaaaag atagccaagt ccgatcaaga tggcacacca 1716601 aacaccggca caccagtagc aattgagcat gtatccaaag ttagaagccg gcacgctttt 1716661 ttcatctaca tgcccgtttt gatcaacaat ccttttcttt ttcataaaag gttttcggat 1716721 aaattctgtg attttgtcaa atacaatcaa atgtgtcagc ctgtaactgg ctagaatcag 1716781 catgataaaa gttagaaaag aaagacggtc cattgagaag cctccaagaa aaaggatgat 1716841 gttatcattc ccaagtgtcc cttatccatt cttgatacaa aaagaaagac ggacagagaa 1716901 tggcctctgt ccgctaatcc gagctcattc cctccagttc tcataataag aggataagaa 1716961 aatgtagaaa aaagcagaaa aatgacaata aaagaaatta tatgactata taatccatat 1717021 atgcactata ttaacggata ttttttaaag tacaataaaa aacattaaat ttttataaca 1717081 ttttttttga atatagtatt atttctttat ttttcgtttc tttttttatc aaatttccgg 1717141 atataaagtg ataaaagtat tgttttacat aaggtcttat acactacttt ttaatcggac 1717201 taattttctt ttgtgcatca ttcttctaat tgttggaagg ttcgacaaag cgttattaca 1717261 gacataaaaa aacctgtttt ctcttggaaa acaggtctcc cgctattatt gatttgccaa 1717321 aatgacagcg atttgatcct caatatcttt tccatcctct tcatcaatca atccatttag 1717381 aagaatagag aaaacaagtt tttttccgct ctttgtttct gcgtaccccg atagagagct 1717441 taccgtactg agcgatccgg tttttgctct tacttttcct tgtgcaggag tgcctttcat 1717501 gcggtttctc agcgttccgc ccaccattct gtcaggattc cccgcaacag gtaaagaatt 1717561 tagataagcc gagaaccaac tctgatcctg aatgtcatat aacagctgtg aaagttgatc 1717621 tgaggataca gcatcaatat gtgagattcc tgatccgtcc cttaagacga gtgatttaga 1717681 atcaacacca aattccggaa gcgtactgtt taacacttcg agcccctttt cccagctccc 1717741 ttctcctttt ttcactttcc ccatctcttt tacgagcact tcggcatgtc cgttattact 1717801 taatttcatg aacggcacaa aaagtttcga taaaggcatt gagcgatgag agagcagcac 1717861 atctgaagaa ctaggtgctt cacccgtctt gatgtcccct ttcacagtaa taccttgttt 1717921 ttttagtgac tgcttaaata aatctaaggc atatccggca ggctcccaga cagaaatcca 1717981 ttcctttgtc ttgtttgcgt caaccggtac gctcccttca attgtaatcg tgtttgttcc 1718041 atgctctctt tcgattgtga ggtctttctc tgaaccggca gcagtcgttt tagcatcgtt 1718101 ctttatcgtt atataatcgg ttttcggaga gacagacacg gcaggctctt ccccttcttt 1718161 ttgatttggg gtgacctcaa caatcacagt gcctgcatca tagtcttcgt ttggagacgc 1718221 tgttagagcg gagattggcg cgccataata tgtgtattca tcgctccaag gcatatcagg 1718281 tgataatcgc atgtcatcat gccacgtatc atcaccgatc agattgcctt taattacttt 1718341 tacgccggaa tgtttcaata tctcagccat tttgtcaaaa tcagatggta aaagtgtcgg 1718401 atcgcctttc cctttcaaat aaaggttacc attcagcttt ttccctttca gtgttccatc 1718461 cgtccggacc tcggttgtaa aagaatagtt ctcgccaagg acagaaagtg ccgcggccgc 1718521 tgtcaaaagc tttagagaag aggcaggcct cattcgggtg tctcctgaat gttcatatag 1718581 aacagcacct gtttccgcag agcgaacggt gatgccggcc attgcgcctt cgagggcagg 1718641 atgatcagct aaaatcttat cgatctgccc ggaaagtgca tcttgttttt cagcggcaag 1718701 cgcagcctga tgcatataag gcaccgaagc aacgacgaaa agcagtaaaa cagcaacata 1718761 aagctttatg ctttttttca ttaatttccc cgcctctctg cgcttcatca ttggctattg 1718821 atgattcagt tcaatggtga tactgctttt agctgtcgtt tcttctcccg gctccagcac 1718881 ttgtaaacca gtgagtgacg aaggtaaatc aagattcact gcgtttgtca cccatgtgta 1718941 aggctcaggg cataaatacc cttgttttcc gtccgcattg tatacaaccc aatgtttaaa 1719001 ctgttcatct gccttataaa taatgctgat atgtgcatgc tgatgataaa tgactgcctg 1719061 gttttctccg cccctcttct gataagaaga taaaaagaca tcatccagct gcttgtggcg 1719121 caaatccatt ccttcatgca aagcttcttt atacgggaca tccatcagct tcccggtcgg 1719181 cagcaggcgt tcatccaact cccattgctg atctgctgtc agggagaata acgagctttc 1719241 tgccggaaat ataaatgtag tatgataacc aattccccaa ggaaacgctt cctttccttt 1719301 gttcatgacc gtcgcatgtt taaatagggt attctccttg atcgtgtatg tcatccgaac 1719361 gacggcatga tgaggaaatt gcttctgcac atggggaagc tcagaaagat caatttctgt 1719421 ttcaacaatc actccttcat cagtttgctt cgtggtcacg acattccact tttcatggta 1719481 aagaaacccg tgaagatggt tgtgtttatc cttctcgttg atatcaaaat gatacgttct 1719541 gccccggaaa ctgaatgtac cgtcacttat gcggttaggc gggaacagga ttggaatgcc 1719601 atacaatgtt ggtgtgtcgt gaaaactttc tgctgtttcc ggttcacgca aaagctggac 1719661 atttgttgtt ttgtccacga gagaaatgac gttgctcccc cactcaggga caacaatcat 1719721 ttctagatgt tcgttgcccg ctttgatggc cggcgttccc aaatacgtga ttttctcaat 1719781 aaagtttgcc atgtttactc aacctctcct tgattcattg ctagtataag aattcaatgt 1719841 actgtaccat atttcctcca ttttatattt tcccctatca aataaaaaaa caccgttcaa 1719901 acttatgaac ggtgtgattc ggaggctatt ggatgagacg tgtgatttgt ttctttttcc 1719961 agacgaattg ataataccca taaatcaaca gcaagctgac ggcaaacgca gctggataac 1720021 caacccagac gccgagtatt tcaagctttg tatagtgaga aaggacgaaa gcgacaggca 1720081 cctctactcc ccagattgca aaaatactga tgacggtcgg ccataaaact gttccgcttg 1720141 cccgcatcgt tgcagaaata atttgggcat ttccaaacag caaatagctc cacagtgtaa 1720201 tcatcaaaag acggtgcgca atgtaaagcg tctcttgctc ggttaaaaat aacgataaaa 1720261 tctgatgtga aaaaacatag atcagaatga tcagtacgcc gccaatgata taattcagcc 1720321 aaatcccaac gcgaatgacc tgctttaagc ggtcaaactc gtttgctccg atcgattgcg 1720381 cagcgaaaat agaaaccgca ataccaaggc tgacggccgg catctgtaca tagctggcca 1720441 cctggttgac cactccgtat gcagctgttg cattagagcc gtaatgattg acgaatgaaa 1720501 taaccgctat ctctgataat gagacaagaa tcatattgat gcttgctggg accccaagac 1720561 gcagcaggag aaccagcagt tccttatcca ttttcaaata acgacgcact gttttatcaa 1720621 attgcagcgg gtgttttcgc tttcgtaaat acaccattaa cacgagaaaa gtcgcaatcg 1720681 tggaaatgac agttgcatat gccgagccgt atatgcccag tttcggaaaa ccaaacatgc 1720741 caaggattaa aacaggcaaa agcgcgatgt tgatgaccgt gctcacaatc agcgtataaa 1720801 acggtgtctt ggaatctcct gttccgcgca aaaaggtagt atatgcaaaa tataaaaaca 1720861 taaacggcat agcataaaat aaaatacgtg catagttagc gctgacatga atgacatttt 1720921 caggtgttcc cattaaacga aggatatcca gggtgaaaat actgccgata acggctaaca 1720981 caacgcctaa taaaaatgta aacgtgagtg tcgtcccgac aacagccttt agccgttcct 1721041 catttttcgc tccgtaagct tgtcctatca gaatcgaact tcctgaaccg atcccaatcg 1721101 taaatgagat taaaagaaaa aataacggga aaaaggatga tacagctgcc actgcatcaa 1721161 caccgagcca tctgcctaca gccatcatcc cgactagctg gccgactgat tgcagcacat 1721221 tgctcagcag aagcggcact aaaaagagtg acatcgaccg ccaaactgat ggtttgcttt 1721281 tcttttgagt tacaagaggt tcttgtgatg tttccatatt aaaggactcc tttatttgaa 1721341 atcgttttta aacatgccct cattttttga caaaaacagg atatgtaaca tgttattatt 1721401 catcactgca cttatgaaac ccttcccgat tcttctaatt ttacacatct ttttagctta 1721461 tgaagaataa actagcaagt aatggcgtat tttttgtgag taaaagaata aaaaataatt 1721521 tatgcaaaag tattgtaatc tatccgtaat tattgtaaca tttgtaacat aagagaaaga 1721581 gattttgaag gagagagcga taatgaaaaa atgtcttcta tttctaacaa ccattgcact 1721641 tattctgtca ttaagcacaa atgcatttgc gaaaaataca tcaggcgatt tatcacaaaa 1721701 acaagcatta cagttggcat tatccgctag agaacatttt tggaacacca tgagcggcca 1721761 caatccgaag gtgaaaaaag cagtttgccc atcaggcaca ttcgagtatc aaaatcttca 1721821 atatgtatac atgtgcagtg atctaggcac taaagcaaaa gcggtgaatt atttaactcc 1721881 tatttttaca aaaacagcaa tcgaaaaagg ctttaaagat tatcatttca ctgtttcaaa 1721941 aggaaaactt gctgttccaa tcggtgacgg agacaatctt ttgaattgga aaaaatcaac 1722001 tgctaaactg atctctaaaa aaggcagcac aatcacatac gaatttactg tccctacatt 1722061 agacggatcc ccttctgcaa aacggaaagt gacatttgtg aaagaaaata aaaaatggaa 1722121 agtcaatcaa tttgacgcag ttatataaga aaaacgcccg gtataagcgg gcgtttttta 1722181 tttggtttgc ataaagaaag acaacaggcg aaaagtgcct gttgtctttt tgtgaatata 1722241 acgctctagg agagattcga actcccgacc tgcagtttag gaaactgctg cactatccgc 1722301 tgtgctacta gagcttttgg tatttatata gtagctctga tgatcaatat tttcaagcga 1722361 tttgtattaa agccctccaa aaaccttata tgcggctctt gtcgtatctt catcaatacc 1722421 gatataccgc attgtaattg atggtgatga atgattcagt attctctgca gctcggcgat 1722481 gtctttcgtt cgctgataaa aatgatagcc aaacgttttc cggagtgtat gcgtccctat 1722541 ctcctcaagt ccgcacgctg cagcggcctc tcttaaaatt ctgtaggcct gaatgcggga 1722601 aatcggcttc ctggtccgca ctgatttaaa aagatattcg ttttccttca tgtctttcgt 1722661 atactcgtat atttcctgtt tcagcgattc taaaataaga atctttcttt tctttttcgt 1722721 tttgctttca gtcgcccata aatgatcttt attttgaacg tccttcactt gcagcggcag 1722781 aatatcagaa atacggagcg cgctgttgat gccgaaaata aacagaaaat aatcccgctt 1722841 gtttttgtta agcaaatact gtttgacttc ttggattttc tctagactgc gaatcggctg 1722901 tacaatatgc atcaaaaaac tccttaaaaa ccgttatgta acattttgag gtctatgtta 1722961 ctattatagc tgaaaaacgt tgaatgtcaa agtgcggcgg cgtttatgta acataatata 1723021 catagtgtta cataagcttt taaaaaagct tcttccaacc ttcaccctat aaaataagct 1723081 ttaaagcctc ttataaagct tttaacctct tggatactta tccccctact aatcatcaaa 1723141 aaacctctta aaatgaaatc tgacactccc aattttctgg agcttccgca aaaatataca 1723201 aaaaaagaca caatttcaaa ttgtgtccta atcctcatcc tttacatcaa tatcttccgg 1723261 gatcggttca tttaatattt cctgcacaag tgctttgtaa ttctccagct gttcgagatg 1723321 cgttttgaac tgttccttat aaatcaaaaa ttgctccccg tcatgaacgg ctctgatttt 1723381 cccttcgagc accaagcttt taatataatc ctctgaaaga tttgtatatt ctgctgtttc 1723441 ttcaatcgtt aaatacatat agcagtccct tcttaatccg tatgctgatt ctaatatagc 1723501 acatggctca tatcaatata atcaattctg cacagaaaaa cggcattatg cactatataa 1723561 tataccattt gtcacttgtg aaaacgctgt aattttttta cgctaagatt gtaacaatac 1723621 agcttcatat aggagggaga acatgaaaag aacgtggaac gtctgtttaa cagctctgct 1723681 tagtgttctg ttagtcgctg gaagtgtccc ttttcacgcg gaagctaaaa aaccgcccaa 1723741 aagctacgat gagtacaaac aagtagatgt tggaaaagac ggcatggttg cgaccgcaca 1723801 tcctcttgct tctgaaatcg gtgctgatgt gctgaaaaaa ggaggaaatg ctattgacgc 1723861 agcggttgcc attcaatttg cactcaatgt aacagagccg atgatgtcag gtattggcgg 1723921 cggcggtttt atgatggtgt atgacggaaa aacgaaggat acaacgataa tcgacagccg 1723981 tgagcgtgct ccagcaggcg caactcctga tatgtttctg gacgaaaacg gcaaagcaat 1724041 tcctttctct gaacgtgtaa caaaaggtac tgccgttggt gttccaggca ctctgaaagg 1724101 gctggaagaa gccttggata aatggggaac ccgttcgatg aagcaattaa ttaccccttc 1724161 tattaaactc gctgaaaaag gctttccgat tgattcggtg ttggcagagg ccatttctga 1724221 ttatcaggaa aagctttcac ggactgccgc aaaagatgta tttttaccaa atggcgaacc 1724281 gcttaaagaa ggagataccc ttattcaaaa ggatttggct aaaacattta agcttattcg 1724341 ctccaaaggc actgacgctt tttataaagg aaaattcgcc aagacgcttt ctgacactgt 1724401 ccaggatttc ggcggatcaa tgacagaaaa agatttagaa aattacgaca ttacaattga 1724461 tgaaccgatt tggggagatt atcaaggcta tcaaatcgct actactcctc ctccaagctc 1724521 cggcggtatt ttcttattgc aaatgctgaa aatccttgat cattttaacc tttcacaata 1724581 cgatgtccgc tcatgggaaa aatatcagct gcttgctgaa acgatgcatt tgtcatatgc 1724641 cgaccgtgcg tcttacgcag gtgatcccga atttgtaaat gttcctctca aaggcctgct 1724701 tcaccccgat tatattaaag aacgccagca attaatcaac ctagatcaag tgaataaaaa 1724761 accgaaagcc ggtgaccctt ggaaatacca agaaggatca gcaaactata aacaagttga 1724821 acagccgaaa gacaaagtag aaggccaaac aacccacttt acagttgctg accgttgggg 1724881 aaatgttgtt tcttatacaa caacaatcga acagctattc ggaacgggta ttatggtccc 1724941 tgattacggt gttattttaa acaatgaatt aacggatttt gatgcgatac caggcggagc 1725001 taacgaagta cagccaaaca aacggccttt aagcagcatg accccgacga ttttatttaa 1725061 ggatgacaag cctgtcctca cggttggatc tcctggcggg gccacaatta tttcatccgt 1725121 tttgcaaacc attctctacc acattgaata tggtatggaa ttaaaagcag ctgttgaaga 1725181 gccgagaatt tacacaaaca gcatgagctc ttaccgttac gaagacggag ttcctaaaga 1725241 tgtcctcagc aagctaaacg gcatgggcca caaattcggc acaagtccgg tggatatcgg 1725301 aaacgtgcaa agtatatcga tcgaccatga aaacggcacc tttaaaggtg tagctgattc 1725361 aagcagaaac ggcgcggcga tcggcattaa tttaaaacgt aaataaataa aaaactgtac 1725421 tcgcttcaaa tgagtacagt tttttcatgc agatctttaa aataaaaact gacaaacgtc 1725481 tttattctgc taatgcacgt ctatcttcat cttttcattt cgtttatctc atcaagaaat 1725541 gtctgaaacg cactcgtaat aaaaaagtct ttcctgtata taaagacgat ctctaagtct 1725601 tgatatgatg gtggcagctg atgaatccat acatttgtac gatgctcgga gccgtcaaca 1725661 gcggactttg ggagcagcgc cgtacccatc ccggcggaaa caccttttat aatagcctcc 1725721 aatgtgccaa actctatgat tttttgattg tgtatgcctg cttcctctag taatcttttg 1725781 accctgtcac gatgagaaca gccagcccca aaaaagagca tcggctgctg aagcatgtct 1725841 tctgccgtcc cttctcgtga tgaaatcaaa actaattcat catgggagac atggagttgt 1725901 ctaactgcag cgtgttcaac cggcccatat acaaaagcgc catcaacttt atgatcaaga 1725961 acctgttgaa tcaaatgatg cgtatcagct gtgttcactg ataaatccac ttcaggaaaa 1726021 cgcctgagga aggatgctgc atgctcaggc agatgcgtta ccgccattgt ttccagtgat 1726081 ccgatccgca aaggcccttt tggttgcctg ctcattcggg tcgatttttc agcttggtct 1726141 aacagcgata atacttgatc tgcatattgt aaaagatttt ctcctgcagc agtcagcttc 1726201 attccccgat tcgttcgatg aaaaagcctg atattcaaat cttcctcaag gttatgcact 1726261 ctggctgtca cattcgactg aacataattc agcatttggg ctgctttcgt tatgcttcct 1726321 tcgcgagcaa cagcctgaaa aatctttaaa tctccgcttt ccacgcgctc tcacctgctt 1726381 gctatgatga aaagtgatat tggctatcat atttgttcat tttactcgaa gaaaaccgct 1726441 atgtaaaata tgtaaagata tgaaaataca attaatgagg aggcagacag catgaaagct 1726501 gtaattcaca acggaaaagc cggtcttctg gggttatcag ttcaggacgt tccatcaaca 1726561 aagcctggat acggagaggt aaaggttaaa ttaaaatctg caggcctgaa tcatcgtgac 1726621 ttgtttctta tgaaaaacaa atctgaacaa gatcctcaca tgatactggg ttctgacggc 1726681 gcgggtatca tcgaagagat tggtgaaggc gtgaaaaatg ttactgttca gacagaagta 1726741 gtcattttcc cgacattgaa ctgggatttg acagaaaatg ttccacctgt acctgagatt 1726801 ctgggaggtc cttcggacgg aacacttgct gaatatgtga tcattccttc acaaaatgca 1726861 atcaaaaaac ctgcttattt atcttgggaa gaagcgggcg ttttaccttt atccgcttta 1726921 actgcatatc gggctctgtt tacaaagggg caattaaaaa aaggcgagca tctattgata 1726981 cccggcatcg gcagcggtgt agcaacctac gctttattta tggctaaggc gattggggca 1727041 acagtaagcg tgacctcccg cagtgaggag aaaagaaaaa aggcgctgaa attaggtgct 1727101 gattacgcat ttgacagcta cagcaattgg gatgagcagt tgcagggaaa aaagatagat 1727161 gttgttcttg acagcatagg acctgccctc ttttcggaat acttccgcca tgtaaaacca 1727221 aatggccgta ttgtcagctt tggggcaagc tcaggggata atctcagttt tccggtgcgt 1727281 tctttattct ttcctcaggt caatgttttg ggaacctcga tgggaagcgg tgaggaattt 1727341 caagctatgc tcgctttcat tgacaaacat aagctgcggc ctgtaattga ccggatatat 1727401 cctttagaaa aagcatgtga agcatataaa agaatgcagg aaggcagaca gtttggaaac 1727461 atcgggatcg taatggaata aaaaaagaaa ccggctggca gccagaccgg tttctcttat 1727521 atgataatcc cctttattta cggaagaact gaactcccca tcaaatatcg atccacttca 1727581 cgcgccactt cacggccttc attaatcgcc catacgatta agctttgccc tcttcttgca 1727641 tcccctgcgg cgaatacacc atcgatattt gtttgataat ccccatatgc tgcactgatt 1727701 ttgttattta ctgaattaac accgaactgt ttcaacagcg gctgttctgt gccttcaaag 1727761 ccgatagcga taaagacaag ctgagcaggc catacttttt ccgttccagg cagctcgcgg 1727821 aactcgtatt ttccatgctc atttttcact ttttccattt ggatggtatg aagctctttc 1727881 agctttccgt ttttatccgc gaccattttt gtcgtttgaa tggagtattc tctcggatct 1727941 cttccgaatt ttgcttctgc ttcctcgtat gcatattcaa gcgtaaagac gtgtggctgt 1728001 tcaggccaca tattgtcatt cgtgcgggct ggcggaagtt tcgggtgttt gccgaattgg 1728061 tgcacgcttt tggctttttg acgcagagcg gtagccacac agtcagctcc tgtatctccg 1728121 cctccgatta cgatgacatc tttccctttg gcatcaatga attgcttgtc tttaaaatta 1728181 gaatctaaat agctttttgt tgcaagtgtg aggtagtcca ttgcgtaatg gactcctttt 1728241 gagtcgcgtc cttcgattaa gaggtcccgc tgtttttgag cgcctgtgca taagatcaca 1728301 gcatcaaatt gctcctttag ctcatcagct gtaatgtcaa caccgatttc tgtgttcgtg 1728361 acaaaatcaa ttccctcttg cgtcagcaat ttaattcggc gttctacaat gcccttctca 1728421 agcttcatgt ttggaatgcc gtatgttaaa aggccgcccg ctctgtctgc tcgttcaaaa 1728481 acagtgacgg aatgtcccgc ttgattcagc tggtcagcac tcgccagtcc ggctgggcct 1728541 gacccgacga tggccacttt tttgcctgtt cgtttttttg gaattctagg ttgaatccag 1728601 ccgttctcaa atcctttatc gataatggtc cgctcgatgt ttttaattga tacggccgga 1728661 tctgaaatcg ctaaagtgca tgatccttca caaggagcgg ggcatacccg ccctgtgaat 1728721 tcaggaaagt tgtttgtttt caacagacgt tccaatgctt ccttccatct gccccggtag 1728781 acaagatcat tccattcagg aattaagttg taaatcggac agccggatgt aaatccgtta 1728841 atgtccgcac cgatctggca aaacggtgta ccgcaatcca tacaccgcgc cccttgccgt 1728901 ttcgatgctt cttctgaaaa aggagcagaa tattctttcc aatcctttaa gcgagtgaga 1728961 gggtcccgct ccgcaggttt ttctcgtttg atctccataa atccagttgg tttccccatg 1729021 ttcctctccc cttccttact gtactaccgc ttgtttttgt cccgatgctg ctgtattctg 1729081 ctttggcttc gtgttggcct caaaagcgaa catgatggct tcttcatctg ataaacctgc 1729141 agctttttgc tcttcgatgc ttgcgagcat ttgtttatag tttttcggaa tgactttgac 1729201 gaattttttc acactgtctt cccattgatc tagcagatct tctgcttttt ggctgtttgt 1729261 atacgcagta tgtctttcaa gcattgcttt gatttgctgg atttctttct catcctctaa 1729321 tgattcaaat aaaatcatct caaggttgca tttgcgttta aacgctttga catcttcggt 1729381 cagtacataa gcgattccgc cggacatacc tgccgcaaag tttttgccta catcaccgag 1729441 aacgacaacg ctgccgccag tcatgtattc acagccgtgg tcgccgatgc cttctacaac 1729501 tacgttcaca ccgctgtttc gaacggcaaa gcgttcacca gcacgcccgt taatatatgc 1729561 ttctccgctt gtcgcaccgt aaaaagccac gttgccgata atgacattgt catccgaagc 1729621 agagttgaat ccttctgatg acttgacgat gatttttccg ccagaaagcc cttttccgac 1729681 gtaatcattt gagtctccgt ccaaataaag cgtcatccct ttaggaacga aagctccaaa 1729741 gctttggccg gctgatccgg taaagtgcag cttgattgta tcttcaggaa gaccttcttc 1729801 tccgtaacgc tttgagattt cactgccggt tatcgttccg gctacacgat ttgtattatt 1729861 gatttcaatc gaaatatcag cttcttttcc agattcgatg gcttcttgta cggccgggag 1729921 aattgttgta atatcaagtg attgatcaat tttatgattt tgcggcgatt ggaacgtccg 1729981 caccccttca ggctgataaa gaagggtaga caaatcaagc tggcttgctt tccagtgctc 1730041 ctttgcccgt tcacttgcat gaagtacatc agtgcggccg atcatttcat caaatgtctt 1730101 gaagcctaac gcagccatgt actcacgaac ttcttcggca atgaacagca tatagttcac 1730161 aatatggtca ggatctccca tgaacttttt gcgaagctct ggattttgtg tcgctacacc 1730221 gacagggcat gtatccaaat ggcaggcacg catcatgaca cagccgagta caactaacgg 1730281 agccgttgcg aaaccaaatt cttcggcgcc gagcaaggca gccatcacaa cgtcgcggcc 1730341 cgtcatgagc tttccatctg tttctaatac aacacggtca cgaagtccgt tcagcattag 1730401 tgtttgatgt gcttctgcaa ggccaagctc ccacggaagc cctgtatgtt taatactggt 1730461 tttcggagaa gcgcctgtac ctccgtcata gccgctgatc acaatgacat ctgcagtcgc 1730521 tttggcaaca cctgcagcga ttgttcctac acctgctttt gacaccagct ttacgctgat 1730581 tcttgcgtca cggttggcat ttttcaaatc gtggatcagc tgggctaaat cctcaatcga 1730641 ataaatgtca tggtgtggcg gaggtgagat taatccgaca cctggcgttg acccacggac 1730701 atcggcaacc catggatata ccttgttgcc aggaagctgc ccgccttcac ccggcttagc 1730761 accttgagcc attttaatct gcagctcatc agcattgacg aggtaatggc ttttgacacc 1730821 aaaccgtccg gatgcaattt gtttgatcgc acttcttcta tcatcgccgt tctcatctgg 1730881 aacaaagcgt ttgggatctt ctccgccttc accgctgttg ctttttcctc caagacggtt 1730941 cattgcgatt gctaaagctt cgtgcgcttc cttactcaag gacccgaatg acatcgcacc 1731001 cgttttaaaa cgtttgacaa tcgattcagc ggattcaacc tcctccaact tcaaaggctt 1731061 gcggtttccg tcaaatgcga acaagttccg caaaaatccg atgcgttctt catcagccgc 1731121 ttttgtatac tgtttaaaca gattgtaatc atttctgcgg cacgcccatt gcaaagtatg 1731181 aatcgttttc ggattaaacg catgatgctc tccgccattt ctccattgga agtcacttcc 1731241 cggttcaagc gttttgctgt aatcatcctg atacgcttcc cggtggcggc gctgtgcctc 1731301 ttctgcaatt gtttgtaaat cgatgccgcc tagctgtgat gcagtacctg agaaatagcg 1731361 gtcgatcaca tcgcggctga ttcctaccgc ctcaaagatt tgtgcgcctc tgtagctttg 1731421 cacagttgaa attcccatct tggacatcac ttttacgacg ccctcagtaa tgctttttcc 1731481 atatttgcta accgcttctt catagctgat atccaaacgg ccttcatcaa tttcctgctt 1731541 gtaggtcgca taagcgagat aagggttaat cgcatctgcg ccataaccga ttaacgctgc 1731601 aaagtgatgc acttcacgtg cttctcccga ttccacaata atgctgacct tcgtacgcag 1731661 ccctttgcgg attaagtgct ggtgcagtgc gcttactgcc agaagcggcg gaattggtgt 1731721 cagtcgttcg ttcatctttt tgtctgataa aattaacaaa cttacgcctt ggctgatggc 1731781 tttctctgcc tgtgtgaaca tgtcctttaa accgcgttca agatcctctg aaaacagcac 1731841 atcaattttt tggcttttta aatcaggatg aacaatcgtt ttcaatgcgt aaaactgttc 1731901 attggataaa acaggtgtat acagtttaat ccggcgaaca tttcgttcac ttggatgaag 1731961 aagatcgcct tccgcaccga gccaagtcat cgttgaagtg acaagctgct cacgaatcgc 1732021 gtcgattggc gggttcgtta cttgtgcaaa cagctgttta aagtagttaa acagcgattg 1732081 cgctcggtca gaaagtacag caagcggagc gtcattcccc attgaaccaa ggggatcttt 1732141 gccttcttta ataacaggaa ttagatactt ttggatatcc tcatatgtgt atccgaatgc 1732201 cttctggcga gtaagaagat cactaaattg ttcttcttct cttgactccg gatcaggatt 1732261 tacttgtaca agctcttctt caagccattt ttggtacgga tactcagttg caatttgtgt 1732321 tttgacttcc tcatcggaga taatacggcc ttcttccagg tcgattaaaa gcattttccc 1732381 aggctcaagg cggtttttat ataaaacgtt ctcctgttca acttcaataa cgcctacttc 1732441 agatgagaaa ataatataat catcttttgt gacataataa cgggccggac ggagaccgtt 1732501 ccggtcaagg atcgccccga tttgtttacc gtcagtaaat gaaatagctg tcggtccgtc 1732561 ccaaggctcc atcagggagc tatggtactc gtagaacgcc cttttttcct tggacatatg 1732621 cgtattttcc gtccaaggct ctggaatgag catcattgcc gtatgtgccg gtttgcgtcc 1732681 agccatcaca aaaaactcaa atgcgttatc caaaatggaa gagtcactgc catcagcatt 1732741 gagaatcggc aaaatcttgt ttaagtcctc accgaagctt tcagaaacaa attgctgctc 1732801 acgtgctctc atccagttga tatttccgcg aagggtgtta atttcaccgt tgtgaaccaa 1732861 atagcggtta ggatgcgctc tttcccatgt agggaatgta ttggtactga agcgtgaatg 1732921 aacaagcgca aaagcagaaa cgaatgcttc gtcttgcaga tcagaataaa atgcatcaac 1732981 ctgttcaggt gttaaaaggc ctttgtaaac aatggtctgg cttgaaagac tggcaaaata 1733041 aaaatcaaga ccttccgtta ctccccaatt ttcagcctgt ttacgaatga catacaattt 1733101 tcgttcaaaa gataaattgt cctttagatc agaacttgcg ccgataaata cctgacggac 1733161 aaacggacag cttttttgcg ccactgttcc gatttttccg acatttacag gtacagttct 1733221 ccatccaaga acgacttggc cttcttgttc aattagtgca ttgatttgct tttcaatttt 1733281 ttttctttca tcttccttct gtgagaaaaa gaccattcct accccgtaac gttctttttc 1733341 tggcagattg atgtttttgc actcttttct aaagaaagca tcagggattt gaaccagtaa 1733401 gccggctccg tctcctgtat ccggatcact gccttgccct cctctatggt ctagctggca 1733461 aagcatctta agtccttgtt tgacaatgtc gtgagtctgc ttgcccttta agtgtgcata 1733521 taggccgatt ccgcatgcat catgttcaaa ttcaggacgg tagagacctt gagcttttgg 1733581 catttgattg tacgtcataa ttcctctccc ccgatcaatt tccgataata ccggtcataa 1733641 aatctaacaa ctctataatc attgtaggtt ttcaaaacga tataaacaat atataattta 1733701 gatcaaaaga atctcaaaat gagatagatg gatgtgagac aaacatggag ctgcgccaac 1733761 tgcgttattt tatggaggtg gctgaaagag aacacgtttc agaagccgct gatcatttgc 1733821 atgtggccca atcagcaatc agcagacaaa ttgccaatct tgaagaagaa ttaaatgtga 1733881 ccttatttga gcgtgaaggg agaaatatca aactcacgcc aatcggaaaa gaatttttaa 1733941 ttcatgtgaa aacggcgatg aaagccattg attatgcgaa agagcaaatt gatgagtatc 1734001 ttgacccgca tcgcggaacg gtaaagatcg gctttcctac aagcctcgcc agccagcttt 1734061 tgccgactgt catttcagcg tttaaagaag aatatccgca cgtcgaattt ttgctgcgcc 1734121 aaggctccta taagtttctg attgaagctg tcagaaaccg cgatattgat ctggccttat 1734181 tagggccggt gccgacgaat ttctctgaca taacgggaaa aatattattt actgaaaaaa 1734241 tttacgcgct tgttccatta aatcatccgc ttgctaaaca aaaaacggtt catttaatcg 1734301 atttgcgcaa cgaccaattt gtattgttcc cggaaggatt tgtacttaga gagatggcaa 1734361 tcgatacttg caaacaagca ggctttgctc ctctcgtttc cacggagggt gaggatttgg 1734421 atgcgatcaa agggttagtg tccgcaggaa tgggcgttac ccttctgcct gaaagtactt 1734481 ttgctgaaac aacacctcgt tttactgtga aaattccaat tgagttccct caagtaaaac 1734541 ggactgtcgg aatcattaaa ccgaaaaata gagagcttgc gccttccgcg aatgattttt 1734601 atgagtttgt cattcaattt ttctctaagc tggagcagta tcaataaaaa aaatgaaccc 1734661 gagcttctat atagaagctt cgggtttttt tctgcaaatt aatttacagg taaagaaaaa 1734721 tccacatggc aaacaaatgc ttcttgatca attagagctc tatttgtcag ttcctttttc 1734781 ttttccggtt cttgaagctg tacagaagag taattgacga ttccaaggcc gatttccgtc 1734841 ccttttgaat ccatcagccg aacaactgaa ccgcttttga atttcccttt aatcttctgt 1734901 acaccgtcta ggtataaact cgattgtccg tttgttattt ttcgtgaaca atcatctgat 1734961 aaaatcattt caccttccgg accggaatta aaagcgatcc attgctcctt ttgattcaac 1735021 ggaagcgttc cttctgcttc aaaataggtg ccttccgcct gttcatgaac ggcgtggtat 1735081 aaaatatcgc cagcatctgc ctgacctagg aaacctttaa tgccagacgc cattacgatt 1735141 ttaaacgcat caagcttaga gcgcatgccg ccggtgccaa cgatgcttcc agtgtcacct 1735201 gcgcatgctt cgatgtcagg tgttatttca ctcacccgct gtatcttttt cgcttctgga 1735261 tttgtgcgcg gattgccgtc atataatccg tctatatctg ataaaatcac aagcatatct 1735321 gcatcaatca atcctgcgac ttttgctgcg agcgtatcat tgtcgccaaa cttgagccga 1735381 ttgacggtaa ctgtgtcatt ttcgtttatg atcgggatga tgccgcgctc gagcagtaca 1735441 ttcattgtat tcctgacatt gttgtatcga tattcatcag aaaaatcgct tctcgtaatt 1735501 aaaatttggg atgcgacata gccgtgtgcc aaaaacagct ttgaataagc ctccattagc 1735561 aatccctggc cgattgaagc tgatgcttgt ttttctggaa gcttctcggg cctttggata 1735621 aatccgagct tccgatatcc cgccgccact gcgcctgagg aaaccaaaat cacttcataa 1735681 ccggcgtctt tgagtttgac gacctggtcg accaacgctt ctaattttcg aatgctgatt 1735741 tctccatgaa ggcttgttaa tgaactgctt ccaatcttca caacgactct tttcatgctt 1735801 gtatcaggcg tcactttatc actcctgata gcggcgctgc agttttttcg atatcttcgc 1735861 tgatttcctt tgaacgctta gccgcatgct ttattgcttg agaaatcgct tctccgccgc 1735921 cgctcttttt caaggcttgc agccccgctg ctgtcgttcc gttcggtgac gtgatattat 1735981 ctcttaagat ctcaggatgt tctcctgttt ccatgagcat ttttgcggca cctaaaagtg 1736041 tctgtgcgcc gatgcttcga gataactgtt tatcgaggcc cgcttcctcg cctgtctttt 1736101 caatgaattc cattaaataa taaaaatacg cgggtccgct gcctgcaatt ccggtgaata 1736161 tatccatttg attttcttgg attgtataga cttcgcccat gcatccgagc aatgcttcgg 1736221 ccagcttctt caggtcttcc gacacatatt tgccaagggc aatagctgtt gcagaagcgc 1736281 caatcatact ggaagtgttg ggcatcactc tgacaaccgg ctgttcatta agcaatgatt 1736341 gttcaataaa agaggtagtt atgccggcaa ggaccgacaa tattaattga tggggttgaa 1736401 tacgtgattt tagtgatgac agagcgtttt cggcgtcttt tggcttcatt gccaaaatga 1736461 gcacatccat gtcttcaata catagttggt tcggcaaggc gcctttaatg ccatattgaa 1736521 gttcaagttc agttaatcgc tctgtattgc tgcggtttgt aacgcagatg ttttgtttcg 1736581 ggattttgtt ggctcgaacg atacctgata tcattccttc cgccatagat cctgctccta 1736641 taaaggctac tttcttttga tcaaagatcg gtaacatctc ctttgttcgc ttttttgttc 1736701 gcattttcac acgtttaaaa tgttaccacg tgaggaaatg atgtcaagtt tgaaggccat 1736761 tattgatttg tattgtttct tttcgacaaa tatgtataat gaaaagcaga aaacacccgg 1736821 ttcacactgc tgcgccgggt gtttgtttct attaaaaatt atctgagaga gctttttcaa 1736881 tcagtttttt acagcgatcc agctctacct tcagctgttt tttatatagc ttggcagctt 1736941 cgtaatcttt aaattgatag aggacgactt cctggagctt agccccttct ttttttactt 1737001 taatttgttt tagtatcccg tcatcaagaa gctcatgcaa agaccggtat acttctgtat 1737061 gatttggttt aaaaccaatc tctttaaatt cagaccgaag tacttcaagc agctttaacc 1737121 catagagtct ctcttgctct gtcatcgtta tcatataaag cttcaaaaat gcgcgctgtt 1737181 tcactaaaaa gcctgttgaa ctcctttttt cttctttcat catatgcact ccttcttctg 1737241 tcactgacaa cactatgtac taaatattca attttctttt attgttttcc ttctttatat 1737301 taaagactga tagtccagtt atttcatgtt tactgattat aggtgtagcg gaaaaaataa 1737361 atttcgactg aacatttggt acatagtttt cttagttcta ttatagcctg catttactgc 1737421 tatcttcaat ttaaacgatt gccagggttt acatatctca ttttaccggt acggatttca 1737481 ttcaaataaa aaaacctgtc gaaagacagg ttttcatttt taaggatttg ttgaccataa 1737541 tcccgctgtt ttgatgaaaa tacgaggatc taatttcagt tgtgccacca tgtactcagc 1737601 aagatcctca ggctgcataa ctttttcagg attaccgtct gttaagttca attcgataga 1737661 catatcacta gcgacagtgc tcggcgttaa cgcgctgact ctgatattat gttttctcac 1737721 ttcttgcata agagactctg ttaacccgag aacggcaaat ttagaagcgc tgtaagcact 1737781 tgttacagca gctcctcttt ggcccgctgt agatgaaata ttaatgatgt ctccggcttt 1737841 gcgttcgatc atttccggaa gcaccgcgcg agtgacatgg tacacaccca ttaggttgac 1737901 ttgaataata ttttcccact catcagctga cagatctaag aaaccgccaa atttgctgat 1737961 gccggcatta ttaatgagga tatcgatatc accgagctgt tccttcactt gagctacagc 1738021 ttggttaacc tgatcggcat cttttacatc tgcagcagca aatgcagctt ttacaccaag 1738081 cgctttgact tcttcagcca ctttttctac attagcggaa gtccggccaa ttaacccgat 1738141 attcacgcct tctttggcaa gcgccagagc agtagcgcgg ccaattcctc tgcctccgcc 1738201 tgtgattagt gcagttttat gttgtaaact ttgcaattga agcacccttt ctttgtttac 1738261 atatgtacga tatcacatta taagtacaat acatccaata cgcaaatcaa acgaactgtg 1738321 taaatatcat ttcttctgat taaaaaaacg gatacagggt aatgacataa gaaaaggagt 1738381 gaacatatga ttatagttta tatcagtctt gcagtattag cagtttctat tatcttctta 1738441 ggagttaccg tgatccaaaa caagaaaaaa atagaccccg cactaaagga gctttcctct 1738501 gttacgcagg ctatgcaaaa acaaatcgaa ggattaaaaa cagaaacaga gctgctgacg 1738561 caaaaacaaa agaagattca gcaggatgtc caaataaaaa aatacacgct tcagcagacc 1738621 gcagctgaag tgaaagaagt tccccaagca gtcaaagagg tgtggcaggc aggacatttt 1738681 aatagcagat aaggatgaat gagatcccgt tgttacgatc agaatggaca aatgggatct 1738741 catttttcga ggaggcttac acatgattat aaaccgcagc tgcttaaaag agttcgcaga 1738801 aaaagtacat tttcttccct cttcacttac aaagtccgat ttacttactg atccatttcg 1738861 tctccatcaa gaaaacgaac ttggcatcta ctattcacct cataatgaat ttatcaatcg 1738921 ggatgcctcg cttgtgattg ccgggatcac gcctggtttt tcccagatga agacagcgta 1738981 cgaaacagcc gccgaaagcc tgctgcaagg cgggactctt gagcaaatgg cagtagacac 1739041 aaaaatagca gcgggtttct ccggatcgat gagacataac cttattacca tgctggattt 1739101 atgcgggctg ccgcaagctt ttggcattca aagcgccgca aagctttttg gagaattacg 1739161 gcatatgctc catacaactt ccgttattaa atatcctgtc tttatccagc aaaaaaacta 1739221 taccggatac aaaccggcta tcactcattc tcctatccta agcacttatg cttttgggca 1739281 cttccctgca gagcttaacc atgtgacggg accagctctt ctcattccgt taggaaaagc 1739341 ggccgaaaca gtgtgtgaaa cattgatcag acagcacagc ctccagaatt tgatttgcct 1739401 taacggcttt ccccatccat caggcgcgaa cggccatcgt ttgaaacaat tcagcaaaaa 1739461 caaagagcaa ctagaaagac aaattcgttc ctttgctgca ttggttgatt tcgctataga 1739521 aaagaggaaa taaaagggat atgataaaca aaaacacaaa cgtggggagt ggttgaatgt 1739581 ttcctatatt agaaacggat cggcttatac ttaggcaaat cacagatcag gatgcggaag 1739641 ccatttttgc ttgtttctca aacgatgagg tgacacgcta ttatgggctt gaaaacatgg 1739701 aatctataga acaggccatt tcaatgattc aaacgtttgc tgccctctat caagaaaaac 1739761 gcggtatacg gtggggaatt gaaagacggg acactaaaga actgatcgga acaattggct 1739821 ttcacgctct ggcccaaaag cataggcgcg cggaaatcgg ttatgaaatc atcccggagc 1739881 attggcgaaa cggatttgca tcagaagtca tttcaaaggt cgtatcttac ggattttctg 1739941 cccttggact gtcgcgtatt ggcgcagttg tatttaccga taatgaagca tcaaatcgtc 1740001 tgcttctaaa aatggggttt caaaaagaag gcgttttaag acagtacatg tatcaaaatg 1740061 ggactccata tgatacaaat gtgtactcta ttgtgaaacc aagagaatga cggtattctc 1740121 ttggtctgtg ccacatccct tttcctttaa aaagataaaa agcgcccctc aaacagggcg 1740181 ctttctaatt aagatgcata ttgaggagat gtttcctcct taactgcttt ttcctcaggt 1740241 atatgaatac attttgtcaa gaccgcactt gcaaggtaaa gggccgcaaa gatccagacg 1740301 acaccttgcg cgccgacgag accgatgaac agccaagcga gtgcagggcc gacaaacgct 1740361 gataaacctg cagctaaatt caatacagac atggctgccc ctttatcttt tcctgccacc 1740421 gtcggcacaa ttgcaccaat cggcacatag cctgccagca aaccgcccca aataaagccg 1740481 atcacgctga caaccgctaa acttccgccg gagaaaacag gtgcgtagta taataagacg 1740541 gtgaaaatgc cgcagccgac tccgccgaac caaataacag tatttttcca gccgaattta 1740601 tcgccgacaa taccgaagat aaggttaaac acaatgttcc ccaggaaaat cgttccccaa 1740661 atttgcagcc acacattggt tgaaattcca tgctgggcca tgtgcatcgg caaaaagact 1740721 ggaaaaccat atgtaccaat gctgttgatg attctgatga ttccgcctgt aagcacgcgc 1740781 ggatttgtaa atagaatcgt aacccctttt aaaagctcct cggctgtttc tgatcttttt 1740841 cttttcttct tttcaaaacg gtctttattg ataaacaatg caaagaatgc accgagacat 1740901 acccagaaaa tagagctcca aagcgtattc aaataaccga acgctttgat cgcgtagctt 1740961 gagtaccaag cgccgaacac aaacatgccg aggcaatatg caatccaaaa ccagccgaca 1741021 gcagtgctca gtttgctttg cggtgttctg taaatgaccc atgtcaagaa agaataagca 1741081 aaaagcgggt aacctaaccc ttttacgaag taagtcacat acatcactgg caggttcagc 1741141 tgttcaaatc caaatacgat aaaagcagct gtaccgatca cataaaacaa cagccccata 1741201 aacatcgttc gttttgcgcc aaatgcttcg agacatacac ccgaaaacca ggaagctatg 1741261 gcaagcgcaa ttccgtatat actaaaaatg gaagcggact gctgaacggt gagcccgttt 1741321 tcgatcaaaa aaggactgag ccagccttgt tcaaggccat ctcccatcat aaacaaaaca 1741381 acccctaaaa atccccaggc aagccgcttc ggtattccta ttttatccaa catatctgtc 1741441 tcctccttag atgctattat tcattaccgt attaccttat taaagttgaa aattaaatga 1741501 ttcctcaaaa cagcagaaat tccgtcttaa attaatactt tgctttctga tcctgaaaaa 1741561 aagcgctgtg tttgcttcca ttcctcatat aaagccaatt ctatctgaca gtccttcggt 1741621 tcgatcaccc ggacatttgc tgacatctcc tccgttaatt gaaaggtttc attgcaaatg 1741681 actgcagcac cgacgacaga tgcctgatga tatccctctt ggacatagac ctttttttga 1741741 agaagatccg cgatatattg agtgagcgct ttgctttgga atccccctcc gcacacccaa 1741801 acataatcac gttcaaacgg agtaacctct gttaaaatgt caaagttcca tttgattgaa 1741861 aatgcgatct cttctagcgc tgcacgtaca aaatgtgccc tctttaaatg tgctgacagc 1741921 ggggcatcaa aaagaaaacc gcctctcgtt aacgcattct tttcagccga taaataagag 1741981 ccgagagccg ctacacatgc atggtcttct tttgcaagtg cagaaatctc ctcctccatt 1742041 acttcgtacg tttcattcgg ataaaaaatc tgttttaatt tttgataatt caagccggta 1742101 attcccggat tcgtttccac aagccaatgc ccttgatccg tatgacagtt caaccaggct 1742161 ttatgttttg tgtcgccatg atcctcagta attttggtta ttggcgttgt tgtccctgat 1742221 acaatgacaa tgtcctcaag tccagctccg gtgcttttga cagccagctg tgtatccccg 1742281 ccccctgcta taaccttagc atttattgaa aggcctaatt cggatgcata ttcatttgct 1742341 atcgttccaa ttgctgttcc cgctcttaca agaggcggaa ggatagatgg agaaaagccg 1742401 aaaatgtcgc acatctcttc tgaccaagtg ttttgcttca catcaaatag cagggtttct 1742461 gttgcctgtg atggttcata tgttaatatt ccgctcagtt ggtacgtcac ccaatcactg 1742521 atgcttgtaa agcttgcagt cttttcccat aaagagggct ggcgctgttt taatccataa 1742581 agcttgagcg cagaaaaaag tgcagttggc aggcggcctg tgctgctgta tatctcttcc 1742641 caatcgggaa tgcccgcctc ccactctcgg ccgcgattat cgatgttcgg cagcccgaga 1742701 aaaggattgc cgttttgatc aatcaaaaca atcccctgtc tttggctcgt cgatgtcaaa 1742761 ccaatgatgt caatatcaca cgaacgggat agcgcacgtt ttgccaaatt catcacctgc 1742821 ttccacagca cctgaggaga aaaataacgg ctgtccgggt aaagcgtctc tgtggaatac 1742881 tcgatgtcct cccgttcaac tgttagaaca ctgccagtta cactcacgac cgctaccctc 1742941 gcattgcctg tgccaatatc aaaaacgaga tagccttttt gttttttcat tctgttagcc 1743001 tcctttctta tccccctgtt ttcagtgcgt ccttgttata cattgtctga atattaagag 1743061 ttttttcacc cttccacttt ttgagggctt tattcagtat cgtcacgtga tgatcctcca 1743121 cttcaaatgt tgctccagcg agatgcggtg ttgccagaac attaggcaat gaaatcaatt 1743181 cataatctga ttcctctgga ggttcatgat aaaaaacgtc tagtatcgca ccgctgattt 1743241 tatgttcttt taatacaaat aaaagatctt cacggtttac aacaactgct cttgaagtat 1743301 taacgaaaat cgcactctct ttcatcagat caaaatattg ccgatctatc agtccgagtg 1743361 tttcctcagt gcgaggcaga tggacagaaa cgatatcgct gtctgaaaac accgttttaa 1743421 gagatgcttt ttcatacaac ggatgatcgt cttgaatgta tggatcgtaa tattttatct 1743481 tacagtcaaa cgcagtcagc agttttgcaa tcctttgccc gactgcgccg aacccaatca 1743541 tgccaaccgt ttttcctgtt agctcatttc ctttaaattt gacataagcc tgcaggtaat 1743601 cactgtccca ctctccatcc ttcagccact gattcgaggc gctggtatgg cgcagaaagg 1743661 aaatcacatt tccaataaac atttcggcaa cggcttgtgc attccgccct ggtgtataaa 1743721 aaacaggtat gccccttttt gaggcagctg ccacatccac atttgagggc attcccctgc 1743781 aaacaccgac aaatgaaagt tcgggaacag aagcaaatac gctgtctgtt acctgatcaa 1743841 gttcagtaat caagcctgtc gcatttgttg cttttagcag ctgaatgagt tcatcctccc 1743901 gatatgccct accttgttcc ttccaagatt gataagcaac tgagccaaac aagttttcaa 1743961 gctcttttcg tccttcttcg ttgtacggtg ctgtaaccaa aaccgtcatg ctgcaaaaca 1744021 tccttttcat cgtatttttc ataaaaaaaa tctctttccg aagatggaaa gagattcata 1744081 tataggcgcg ctctgttaca ggcagacgcc ggtataaacc ttgctttcct atctttcaag 1744141 ctagcgcttg ctggaattgg cacaataatg ttgccgaggt ttcatagggc cagtccctcc 1744201 acctctctgg atagaaaata ttgagtatgt aattttcaga atgaagaata cgtttatcat 1744261 aaagaagact cagattgatg tcaatctctt tttttcagaa ttgacgttat catcggaaat 1744321 gttataattc ttacaaaata tctaactaga gagaggaact gggccatgag atcttttgcc 1744381 acacaacaaa acggcatttt caaatccgtt tgctcgctgg actgcccgga tcagtgcgga 1744441 ttgttaatac ataaaaaaga cgggaaaatc gtaaaagtgc aaggagaccc tgatcatcct 1744501 gtcacagctg gaaacatatg caacaaagtc cggaatatga cggagcgcat ctatgatgaa 1744561 aagcggctga ctacaccgct caaacgaaca ggtgcgaaag gccaagcgat atttgaaccg 1744621 atttcctgga aagaggcaat cgatacgatc acctcccgct ggaaacagct gattgatgaa 1744681 gagggagctg aaagcatact tccttacagc ttttacggaa atatggggaa attgacagct 1744741 gaaggaatgg accgccgctt tttttaccgc atggggtcaa gccagcttga acggacgatt 1744801 tgcagcaaag cgggatctga aggctataaa tatacaatgg gcataagcgc gggaatcgat 1744861 cctgaggaaa ccgttcatac aaaactattt attttttggg gaatcaacgc ggtcagcaca 1744921 aatatgcacc aaattacgat cgcccaaaaa gcgcgaaaaa aaggtgccaa aattgtcgtg 1744981 atcgatgtgc ataaaaatca aacaggacgt cttgcagatt ggtttatccc aataaaaccg 1745041 ggaaccgaca gtgcacttgc tcttggcatc atgcacattt tatttaaaga aaaccttcat 1745101 gatgaagcat ttctgtccga gtacacggtt ggctatgaag agctccgtga acacgtgaaa 1745161 caatatgatc ctgaaaaggt atcgacgatc accggtgtca gtaccgaaga tatttaccga 1745221 ctggcaaaaa tgtacgggga aacctcccct tcttttatca gaatcggaaa cggaccccag 1745281 catcacgata acggggggat gattgtaagg acgattgcct gtcttccggc gatcaccggc 1745341 caatggctgc acacaggggg cggcgcaatt aagcataaca gcggaatttt agaatataac 1745401 acaaatgcct tgcagcggcc cgacttattg aaagggcgca ccccgaggtc gtttaatatg 1745461 aatcagcttg gcagggtgct tttggaaaca gacccgccga ttcgctctct atttatttac 1745521 ggaacgaacc ctgccgtcgt cgcgcccgaa gcaaacaaag tcagacaggg cttgctgcgg 1745581 gaagacttgt ttactgtggt tcatgatttg tttttaacgg aaacggctgc atatgcggac 1745641 attgtactgc ctgcaacatc cgcttttgaa aatactgatt tttacacctc ctactggcac 1745701 cattacattc agcttcagca gccggtgatt gagagatatg gggaaagcaa gtctaacact 1745761 gaggttttcc gattactggc tgaagccatg ggattcacag accaggagct taaagattca 1745821 gatgaagtat taatccgcca ggcgcttgac catccagata atccgcattt ggcagagatt 1745881 gattacgatt cacttactaa gcattcattt atgaaagcga aacgtgaaaa gccgctgttt 1745941 ccgggcgaac ttccaacgcc aagcggaaaa atagaattat attcagaaaa aatgaaacaa 1746001 gacggcttcc ctgctttacc gacatataca cctcttgtaa ccgataatga acatccgttt 1746061 atgtatgttc cggggccaaa ccataatttc ttaaactcaa cattttccaa taatgaaaaa 1746121 cacatcaagc ttgaaaagac gccaaagctc tttatcaaca caaaagatgc tgaaaaacac 1746181 ggaatcgttg atggggcacc tgtacgaatt tggaacagcc ggggagaatg cgagctgacc 1746241 gctgcagttg gagaacaagt gctgccaggt gtcgttgtca gccaaggatt atgggcggat 1746301 gaacaaggaa aaaaacagct tgtaaacgcg ctaaccccag atcgcttgtc cgatatgggc 1746361 ggcggcgcca cctttttttc aggccgtgta cagattgaaa aggtttgaaa aataatgaaa 1746421 cccggagtat gccaagcccg tataacataa catcgacata atggaggcat acacatggac 1746481 gtttttttag gaattggtat tgctttggct ggatatttta tcggtgaagg cttaaagcag 1746541 aggaaccaaa ccaaaggtaa tgaacaaaat gatatcttcc taataaaaga acgggatatt 1746601 tacttttaca ttggactttt tttaggaata acaacgactg aagcaaaaca gttagctgga 1746661 gacatggcag acctgcctta catcgaaata aacggaaaaa aatatgtcca gaaacatatg 1746721 ttaaaagatt ggacattcac attagttgaa aaacatcagg gtgaataaaa caaatctgag 1746781 gagagcgaga ttcattgtca cgctctcctc tgtttagctg tatggatcct gccaccaaaa 1746841 ctttgtgcta taagcgctga taaaacgata aaccaccatc tatgttcttt cctcaaacaa 1746901 ctcaagatgc ccgttccaca acaatagttt ttatattcct ttgatgacgt gatgttcttg 1746961 atgaacgtat gtatcgtaaa acacttagaa aacctattcg gtttgaatgt gtgctctcat 1747021 tatgccccca tactgcgcct ttatccgcgg aggatttttt taaaaaaata tgaaacctaa 1747081 agcttttaga tcctgaattt ttattgaacc tccatatttc tccgattggt aaaaattagc 1747141 ctatacaccg gaagctgtac gtttataaag gatcagagaa tcccataacc agtaaatcac 1747201 tgcagccgca atacttaaca tataataaaa gtacgattgc aatgtccatg ctattgacgc 1747261 aggttcattg ataacaaaaa acaggaaagc tgcgataaaa gcaaccacac tgtaaatcaa 1747321 taggtacatg acattgaaag ttctcgcttt tttctgcaac ttcatttgga gcggaacagc 1747381 aaaaaggcca tacaccacaa aaccgtataa taaagcaatt gctgccgtaa acaatgcaat 1747441 tatcatatcg ccatacataa cgaaagaata aaaccctaat aacaaaccaa atgtaaggct 1747501 ggatagccct aatgtcatta aataatatga tgcgattttt ttcatttttt cacccccctt 1747561 gtttgattta ttcacagtgc tgttagtata aattcacaac ctttgtattt cttttatcga 1747621 gatgtcttcc ctaacgtgct atacgcaatg cgctaataaa aggtttcaaa aatgacgttc 1747681 ttttattaga taatacgctg gctgaaaacg cctctcctga ttggccaaag cgcgaatgaa 1747741 aaaagtgcat gaatacctgc ccaacagaca gaataagaag agttgatatt tcaacacttt 1747801 tcgtaaaggg gtgaaaccaa tgagtaagaa aggtattcaa aattcaagta ttgaacaaat 1747861 aagaaatgac catgagactg aaacagcttt taaagcagat gatcctaaaa aacacggttc 1747921 cgatcctaaa agaacgaaat aagttcttac ccccactaaa atatcaataa tctggaggaa 1747981 gtaaagtgac tcaaaaaaac ggtgcagaca gacctgatga ttataaaaga ttttcttcat 1748041 tagacaagga atatgatttt cagcaatcta tacgcagcaa tactgagaca gaaagtgtaa 1748101 acactgaaac acaaactcat aacaaagaaa acaaaaatga cacaacagat gttgccggga 1748161 aatactttga gccctcagat tataaaggaa gcacgcaatt agaaaaagga ttggctgaaa 1748221 ctcatgaaca ggtcagcgat gactattttg aagggacaat cgatcaaaat ttggactagc 1748281 catacaaacg gaactaactt aaaagaagtc agttaactct gtttttagaa acaaccacag 1748341 taaaagtagc caacccccac cgaataagat gggggttgca cgtaagtagc ctgtttaata 1748401 tttaaaacga ttaatgacgg tttgaagttc ttctgccaac tgagatagag attctgcggc 1748461 ataggagatt tcccccattg aatgaagctg ttcctgtgat gaatttgcaa ccgcttctgt 1748521 atttgctgac gtttcttttg taccagcagc caatgtatga actgtgtgct gaatcacttc 1748581 aacgcctgaa gtaagctgtt gagttgctgc tgcaacttct tgtatttgag aagtgacctg 1748641 ttccaccagg ttcagtattt cattgaaatt tcctgttgtc tcttgagaaa gaacaatacc 1748701 tgagctcaca ttttcttgaa caactttaat attatttacc gtttctatcg attcgttttg 1748761 gatggtcgct accaccgatt ggatgtggtt tgcagattta tttgtttcat ccgccaactt 1748821 ccgaacttct tctgccacca cagcaaatcc ttttccttgc tctccggctc tggccgcctc 1748881 gatcgctgca tttagtgcca acaaatttgt ctgctctgaa atcgtcgtga taagcgaaga 1748941 gatatcgctg atttctgctg tgctcgctac caatgtttgc aatccattgc cggctgaatc 1749001 tacagattta tcaatgaatt tcatctggtc taacatcttg ttgacggact tagagcctat 1749061 ttcagccttg tctctcatcg aagaagaaag atccgctatg ttccctgtat ttgaagcgac 1749121 tgatgatata ctgtctaata attcagtgat ggattctgcg ctcttttctg tcattgagct 1749181 ttgcttcaca ttgctgtcgg cagccatctg catggctcgt gaaatatgtt cagatgttga 1749241 tttcgattct tccgcgcttg ccgataattc ttcagaggaa gcggcgactt gttcagatga 1749301 gctgctgatc tgcttcacaa tttgagttaa tgaatgagta aaagaattaa aagattgggc 1749361 aagctggcca aattcatctt tatttttcac aatgactttt ttggttaaat cagcctcgcc 1749421 gtgtgcaatt tcctccagct gcttatttat gcttcttagt ggcaccataa tggactttaa 1749481 cagcattatg cttagaacaa tgcctaatat tactgatatc cctgtgacaa tgataatgag 1749541 cgattgactc attttcccat tgccctgtat ttcatccttt agatcctcta cctcttgatc 1749601 caggcgatca gacagcttat tgacagccgg agctacgcct tcttttctta ttgttctttc 1749661 ttctccaaaa tggatggttt ctgctttttt aggatttgaa gagtaggctg ttactacttg 1749721 ctgattcaaa gctctatact gagtaaaact tgtcttaatg tcttcaatat tggattgata 1749781 cttctcttca tcaatcaagt cattaacccg gtcaaggctc tttaagacat cgtctgcttt 1749841 tcccttcata ccctcgtcgt attctttgtc tctggtaatc aagaagcctc tttcatcatt 1749901 tgataacccg gtcaattcat attggatgtg ttttatctct ttttggaatt ccattttgtc 1749961 tttaagttct tcattctttt tcacagtaga agaaatcata aatactgagg agcctccaat 1750021 tccaataatt gaaacaacta atattgatat aatccccagc aattttgttt tcactttcat 1750081 gtgtcgtttt ccctttccgc acaatgtaat ggctgaaata aaatatgttc aagcgcgttt 1750141 gaatccaatt cgcttacgct catgtccata atatcgacac gtgttatcaa gttttatagt 1750201 gatattctta tatgaataag caaattcttt acgtctctga acttacagaa aaaccttaag 1750261 taaaatttgc agtcttttgc ggtatgtaag tcactcttat tcgtttttct aaaaaaggct 1750321 tttcccacct caaattggct gaaccggctg ttttctcgaa aatataatac aatacgcagc 1750381 ataatatgaa ggagcgaaac ttaaatgggg atcatcaatg gtaaagaatt cattgaccga 1750441 ttgaataaac tagaaaacga aatatggtat gatggcgaaa aaataaaggg taacatttct 1750501 gagcatcctg catttaaagg aataatcaaa acaaaaagct cactttatga attgcaaaca 1750561 aaggatgagt taatacatga aatgacttat tgccttcctg gagatcataa tcgaatcggc 1750621 ctttcctatc tccagcctaa aacaaaaaat gatttgaaaa aaagaaggac catgattgaa 1750681 cattgggcta gacatactca tggaatgatg gggagaagtc cggattacat gaatacggtt 1750741 atgatgagct ttgcttcgtc agcggagctt ctaaaagata aagagaattg ctttcctgaa 1750801 catatactag atatgtatga acaagctgct aagcatgacc tttcctttac ccatacattc 1750861 attactccgc aagtgaaccg gtcacagtcc tattttgggc taagtgaaaa accgatatct 1750921 gctaaagtca ttgatagaac cgaaaaaggt ttaatgattc atggcgcacg actgcttgcc 1750981 acacaaggcg ggttgaccga tgaaatcttg gttttttcag cgcctaaatt tttctttgaa 1751041 acagatgaag cttatgcttt ttcaatccct tctaatacaa aaggcgtaaa attcatcaca 1751101 agagaatcat ttgtattaag cgactcttcc tttaatcatc ccttaagctc aaggtatgaa 1751161 gaaatggatt caattgtggt ttttgatcat gtgttagtgc cgtggaatcg tgtgtttttt 1751221 tacgataatg tggaagcagc taaagatttt atgacaaaaa gctcttttca tgcctttacc 1751281 tttcaccagg ttgtcattag gcaaatgata aaaattgaat ttctattagg tgttgcacag 1751341 cttcttgtcg acaccattaa tgtttccgaa tatcagcaca tccaagaaaa gctctcagaa 1751401 atcattgtgg gattggaaac aatcaaagcc ctcattgaca aatcggaaaa tgatgctcag 1751461 ttagatgaat tcggctatat gcgcccctgt ttaattcctc ttcaagtcat cagtacgatc 1751521 attcctaagc tatatcctcg atttactgaa atcatacaat taattggagc tagcggaatg 1751581 gtgacactgc ctaccgaaaa tgcatttgac tcagagatac gggaagatct tgaccaatat 1751641 cttcaagcaa ccaatacaaa tgctgaagaa cgtgtgaaaa ttttccgttt ggcatgggat 1751701 ttaacaatga gttcattcgg aactagacaa actcactacg aaagatattt tttcggagat 1751761 cctattcgga tttcaagcag gctgtatacc agttatccaa agcaggagca gttgaacatg 1751821 attaaaacat ttttacatgc agatacagaa cattgaaaaa acagcgggaa aagatccgct 1751881 gtttcgtatt ttttattcag gaaactgaac atggcccggt actgtatagg ctttggacgt 1751941 tccgctttca ggcagctttg gaatggtgtc tttcacaact tttccgcgga tgtcagtcat 1752001 tctgactttg agagagccag tacctaaatt cgtactcaca aaatggttat agtccatttt 1752061 ctccatgttg atccacttac catccttttc atattccatt ttcataacag gatacttgtg 1752121 atttctgact tggattgctg cccaccacct gctgctgcct tctttgatcc ggtacgtgaa 1752181 attgccggtg attggggctt tgacaacacg ccatttaata ttgatttttc cgtctttcat 1752241 attgccgatt ttacggaagg cattaggtga cagatcaaga gctccccgag cgccttcggg 1752301 ataaagatca gtaacatata cggttgtttt cccttttggc ccttcaactt ccaaataaga 1752361 gccggcaagt gccgctttta ctcctccgta attgagatcc gccggattta ttgcagtaat 1752421 ctccatatcg gaaggaatgg gatccagcag gaaagctcct cctgaatagc ctgaccctgt 1752481 atacgttgca taaccttcat gcaggtcgtc atatgctgcc gaagcttgcg gggaaaaaca 1752541 gaagatcgtc aacaaaacca taccaacaaa tgcactcatg atctttttca tatttggtcc 1752601 tcctcaaacc agacttcaaa tgagaatcat tatcattata agactcaatc catctggttt 1752661 gaaagaggaa atagattcat agttgatttt aaggcaaatt cactatcatt catatatcaa 1752721 atgtaggtac ttatgaaaaa gccaatacaa atgaacgaat gtgcacttca gccgaatgtc 1752781 ttatttttcc ctctcaaaat tcgcatttca ataacgaaat gaaacaggct gttggcctga 1752841 taacagctat acaggaaaag ctatttttcc ccgctcagtt tcaacttagc tgtcatcatg 1752901 atgccaaaga tcagcacaat cggaacccaa ataatgaagt gataaaaatc aggctcagcc 1752961 agagcaacaa taatagcccc tacacaatac aaaataatag ccagtgctct taacacagta 1753021 tctcttaaga aagtcttctt ttgcttctta aaaaacaaac ggccggatat atcctctaaa 1753081 agagaagcca aagtgccggt caacacagtt gaagaaatac ctgcaatccc cagttttttt 1753141 gctgctgtag tttgaatccc catagaaatg ctcatgagta taattagaat gtgcacagga 1753201 acaaatgccc ggtaaaaaga aagacaagca aagacaaaca aaatgaatgc ttcaagtgcg 1753261 agggcttttg tcacagcaga aggccaaagg gtattttccg cctttccgac catcaatgta 1753321 gcaatgatca cgccgcatat aaatccgatt agcgcagtca aggaattaaa aacagtgacc 1753381 tgaatggatt tgccgatagc taaccccaat aatacaatgt ttccagtcat attagctgtg 1753441 aacacatgtc ccaggcttaa atacccgatt acatccacga ttccagctgt taaacataaa 1753501 agtgatagca aggtgtttcg ataagctgct gcagtcaacg gtgtatcaat cctttcttct 1753561 atttcaattg ttagtatgtc ttttggcgca atctctattt tttaagtaac ccaacattaa 1753621 ttaggaagat agaacctatt attcctttcc attaactgta ataataatcc ccgcaaggaa 1753681 atgattaaaa ttgaaaggaa gcatattgtg atgaaacgac tttgtttatg gttcaccgtc 1753741 tttagcttgt ttttggttct cttgcctgga aaagcattag gtgcagtcga ttttccgaat 1753801 acctcaacaa atggcctttt aggttttgcc ggaaatgcca aaaatgaaaa aggcatctct 1753861 aaaacgggca caacgggtgg aaaaaacggg cagattgttt acattcaaag cgtaaatgat 1753921 ttaaaaaccc atctaggagg atccactccg aaaattttag tgcttcaaaa tgatctttcc 1753981 gcatctgcga aaacaacagt taccattggc tcaaataaaa cactcgtggg ctcttacgcg 1754041 aaaaaaacgc tgaaaaatat ttatttaaca acttcatcag cttttggaaa tgtcattttt 1754101 caaaatttaa cgtttgaaca cagtccgcag attaacggaa ataatgatat ccagctttat 1754161 ttagattccg gtatgaacta ttggattgat cacgtcacat tctcaggtca tagctataat 1754221 gcaagcggaa gcgatttgga caaactcgtg tatatcggaa aatccgcaga ttatatcacg 1754281 atcagcaact caaaatttgc gaatcataaa tacggtttga ttttaggata cccggatgat 1754341 tctcagcatc aatatgacgg ctacccccac atgacaatcg ccaataatta ttttgagaac 1754401 ttgtatgtta gaggcccagg tctgatgaga tacggttact ttcatgttaa aaacaattac 1754461 agcaataatt ttaaccaggc gattacaatt gctacaaaag caaaaatata ttccgaatat 1754521 aattactttg ggaaaggcag tgaaaaaggc ggcatccttg acgacaaggg cactggttat 1754581 ttcaaagaca taggcagcta tccatcactc aacaagcaaa cctctccgct gacttcttgg 1754641 aatcctgggt caaactatag ctatcgtgtc caaacgccgg aatatacaaa agaatttgtc 1754701 acgaaatatg ccggatcaca aagtacaact ctggtatttg gctactgata taaaagaggc 1754761 cctgcgttaa aaacgctgtg cctcttttta tactataggc tatttttaag cgatccttgt 1754821 aattccatca agatccagcg tcggtcaaac taaaaagcat atgttctttt ccacaataac 1754881 ttcttaactg gctttcttat tataccagtt tatcgcaagt gaaaagaaat cattgttctg 1754941 aacctgtatt aaatgaacga tcgtcccaca aactacttaa aaacccctaa aaaggatgat 1755001 ggatatgtgc ggcaggttta ctttgtactc tgcatttgat gatattattg accagtttga 1755061 catcgatcaa ttttttccta aaggtgaata ccagccaagc tataatgtcg caccatcaca 1755121 aaacatcctt gcaatcatca atgatggatc aaataatcgc ttaggcaagc ttagatgggg 1755181 acttattcca ccttgggcaa aagatgaaaa gatcggttat aaaatgatca atgctcgagc 1755241 cgaaacaatt accgagaaac cggcctttcg aagaccgctt gtcagcaaac gctgcatcat 1755301 accagcagac agtttttatg aatggaaacg gcttgattcc aaaaccaaaa tcccaatgcg 1755361 gatcaaattg aaatcatctg ctctttttgc gtttgctggc ttatatgaaa agtggagcac 1755421 acatcaagga taccctcttt atacctgcac catcataaca actgagccta atgagttcat 1755481 gaaagatata cacgaccgaa tgccggttat attggcccat gatcatgaaa aggagtggct 1755541 taaccccaaa aatacaagcc ctgattatct gcaaagtttg ctgctgcctt atgatgctga 1755601 tgacatggaa gcataccagg tttcatcatt agtaaattca cccaaaaata attcagctga 1755661 gcttcttgat gcagaaaatc atatgtagtg attgaaaaaa ttctctagca agaacttgtc 1755721 aaatagcttt gttccttagg tgccaatccc tctagtaatt atgaatattt agtacataga 1755781 tcaattagtt atctttagca tcagtttgaa ataattttat tatgtaaact taaataagca 1755841 atgttattcc tttcatataa aatagtttac atttttataa aatcgcttca cttttctatt 1755901 ttgtcagcaa aaaaactgaa ccacattaaa cttatgaaac ctgccgcacc tgtggattgc 1755961 aaatatgata taagcccata gaggtaaatc catacacttt ccctcctaag aattaaatga 1756021 aatttctttc atcttacatg aaggtcttct ttcttttgtt tatccagtgt aatacttaat 1756081 aatatgttga tgaatgcagc tggaaaatat ataaatccca ctccaagaat gcctagtatc 1756141 gtacttaaac ttactatgta attctttgtc atcgtttgac tgtcaatcaa tattagaagt 1756201 gaaatcaatc cagctaaaac acctataaac caagcatcgc caacagcata agaatcatcc 1756261 agcatcccta accatcgccc caatatagag ctcccaatgg cagtcaaact ggataaaaat 1756321 atgagtgctt tcatttcttc tcctccttta aagccaatca aactggtaga aatcggccat 1756381 tgaatcccca ttatcgaatg gttaccattt catttccaca ttaacatttt aaagctcatt 1756441 acaatacgat tcaagcagaa aaaccctaca taacgtatat atagggattt aataaaacac 1756501 aggccaaaat tcagctctat ctactttaaa aagatatgaa gggcagctgt gtgatctgtt 1756561 acgtctttac gtaccgggat atttcacaac aggcactttc ttcttgcgca gagaatcaag 1756621 catgactgat ccagcattca agttgctttg tactaattct ttaggcgtca atgccatcca 1756681 ctgattgagt gacacatctg catagcggtt acttttgaac atttctaaaa accataatgt 1756741 ttctgtacca gtgttttgta tatagtgtcc ggcattagaa ggcacgtatc caacgtcgcc 1756801 tgctctataa tcaaatgtgc gggcagtccc atttccgata aataccgtca ttcgtccctg 1756861 tcctgttaga taatattgcc actcatcgct attgggatgc caatgaagct ctctcatcgc 1756921 gccaggctca atctgaacaa gtgcagcggc tatcgttttt gaaattggga agttagaaga 1756981 atccacaatt cgtacactcc cccctggcat ttgaattggg ggttgattta acagctcgtg 1757041 tttaaaggtc atggggactt ttccatatgg tgactgaatg tcttcactgg cgactgatcc 1757101 cggcacattc ccttggtaga tatagacttg ctcagacgga agagagttga aagcattctc 1757161 cgggacaccg aaatttgcag acagaacatc ttttggtgtg tgtgcaagcc aatctgaaat 1757221 ggttaacgtt gaaaactcag aaaagttccc atcatcgaaa acgagcagaa actcgcagtg 1757281 ttccaatccc tgtatggaat gcggaattcc tgccgggaag taccaaaggt cgccgggacc 1757341 aacatcagca atgaaatttc gtccgtcttg gtcaacagcg gtgatacgtg cccgtcccaa 1757401 aagcatataa gcccactccg cttgcttatg ccaatgaagc tcgcggacgc ctcccgcagt 1757461 taagctcatg tttacacctg caatcgcagt cgaaatcgga agctgtctta cggtgatttc 1757521 tcttgaccag ccgccgtgat ctaatttcat gggagcgtct gagaatgaaa atctcaagtt 1757581 aggaatcata ccctcatctg taacaggcgg aacaaatata ttcggatttt gaatatcccg 1757641 tattatattt cgcgggcctg tatcaatagc tccagctcca tcacttcgaa taggctgcgg 1757701 cacgtttctg tcttcatgat tgattggttg ttgttccaac agcatgcacc tcgttttaga 1757761 aatgaacaag attttatttc agcctatgca gaatcttaga ttgctgtgcc taggaatccg 1757821 caaataaaaa agtgaccacc aatgtgatca caaatacatc aaataaacta ttttttatac 1757881 catggcttct tatgtaattt gattgcttct gtctgttttt tctggcctgt cctccactcc 1757941 acttttacta atacatcatg acctatcact tcatcttcag gcatataatc aaaggtggaa 1758001 atatggtcct ccatgcgtcc cccacccggc atttcatcac ctgtgtactc cgataagtcg 1758061 tactcatcta cgttatcatc ttgatacttt tcgccatcta catacagagt aattctttca 1758121 acaacagtcc acttttcttc cttcttactc ccctgccaat atagatttag aaaataattg 1758181 ggtccaattg aagttttgtc tgatttttca aggttagaca tccacagtcc gcttttcccg 1758241 ctgccctcat atttcacttt gttccctgac accattacaa ataatgtgat gatgcagatg 1758301 atcaagaatc cagcaatgat caatagccat ttcttaatat tgttcttttt tctcatgttt 1758361 ttcctcactt tcctaacttt ttagtaggaa aatacgatca aaatgttacc gaaaagaaaa 1758421 taagaaaggg ctaatgatct aacagatgac tgtctaaact tttgacttaa attaaagtgc 1758481 tttctaaaga caagattaaa acgtataaca gctcttaaat gcattttttg tttcattgag 1758541 tcaagaacct taaaatggct ttttattatt aaaaatcaag ctagtgtatt aagtaacttt 1758601 tcaaatttat ttatactcat gatctcgtga gtcacaaatc tcccatcaaa aaaaacgcta 1758661 aaagttgtcc aaatagctgg tgacttttgt gcctcttctt tcgatgataa ctgaattgac 1758721 tgaaattgaa cccctttctt ttcagtcaat tcccgcaaat catttatcat gcccactgca 1758781 aacggacact gagctgtata gtatatcgta atcccctttt cattgataga atcacttttc 1758841 acctggctct taaatgcagg agaatctgca aggccattcc aagtcaaagc cattaattga 1758901 aaataagggg cagcttcatc ttgtagagta aaccccatat gctcaaagaa atgcttatca 1758961 cttaaatagg gcagtttttt cttgcctgcg atatggataa tgccatccat gccgcacgct 1759021 ttcgcatctg ctatacattt gtccaacaat cgtttcgcat gaccgttatt tttatatctg 1759081 ccagacaccc acagacaatt aatgtacata aaattaggcg cattgatagg cacccatgcc 1759141 tcattcgcag gtaggtattc aataaagact tttgcccgtt catgtaagcg atagaacacc 1759201 aatccttcat ccattcgagc tttgagccat ctcttctttt cattaactgc atgctcatat 1759261 tgtttcgtgc ttaatgcaca gcaaatatga ttgtcttcaa tattgtcctt tgtgatttca 1759321 atgtagcaca tctcctcttt ccccccttta acataattac atggaattca acttcacact 1759381 ttacatgcct aatagaataa atacccgttc caacttaaat actttttctt ttccattttg 1759441 ccaattaact gtaaaaccct tcttttattc agatattatc ttgattccta tatcacccat 1759501 ttcaaatcca aagtgtgttc atctttgagg attagatgca ctgcttatgc tataaataca 1759561 gtacacgaag ttttttattt gaagtaatat ttgttacggg acagcaatag taaataagtg 1759621 ataaaagggg aattaaactt ggtggaaaaa tgttattctt gtttaatttg cggatacaaa 1759681 ggattaattc aaaatccttt gtataaaggc gagtatcaaa aaacgtttga catttgtcca 1759741 tgttgcggtt ttgaatttgg ctacagtgag gatcatgatg tgaggttagg ttttattgta 1759801 actcctgatc atttaattga ggctgcattt caattgtatc gcaaacaatg gcttgagagc 1759861 gggatggtaa ttgctcatcc ggaagatatt ccagaagaat tgaaaaatgg caattgctta 1759921 aaatttgaag ttttgttgaa acaattgaaa aaactaaatc ttgacataga aaattttgaa 1759981 attagcggtt tttaatgatg aaacaggttg cacttgttta ggtttcactg tcattatcag 1760041 taaaatgtta agttgaaatg cgcaatcagt cacaaagtct ctattcgtat tcaataaaga 1760101 ctttgtgatc atcgacaaac atttcactcc catcggataa agtatccaaa aggcctcctc 1760161 tggttcttct ctatagtcat taatcacagt cactttgaca tttgactcag ctatgattgg 1760221 ttttccaaca atttttcgtt ttttcctcag gcaaagtaag agatcgaatc atcaaagcca 1760281 ttccatcttt actgtctaat taacgccatc ttcagtgaat ttaaaggtct gttttaaatt 1760341 gcgtccttct tgccccttct gtgtccaaat tataacaacc tctaattcag aggccttatc 1760401 tgccagcata aaatgattga acttcagcgg tgagccatca tttaaacttt cagctaacat 1760461 tttagaatct tcttttggtt tgacacaatt ttcatcggga catccaaaaa gcgaaaacct 1760521 tgtgattgaa ttagggtcat ttctatacaa ttgcacatcc actgtagctg ctttttcccc 1760581 tatatttttg acttccaagg aatatacttg atattctcct ttatgaggtc tcgtaaattc 1760641 ctttacattt tttgcttcac ttacttttac tgaccactgg tctgtttttt gtgtaatagg 1760701 caacaccgta aaagtcaggg catgcgcttt tgattggcaa aacgtaaatc caactgctgt 1760761 aaaaacaatt acagaaaata ataccctttt cacttcattt atccctcctt cctttcactg 1760821 gccgctcctt aaagaattga ttttgagcaa tctacaagct ctcttaacca aaaccttacc 1760881 tgaggttttg tctttactgc tctgcattta tttctttcgg tatccgagaa ggagctttgg 1760941 ggatttttct caatctgctg ttaatcacat cagaagagta tagcgtaata atcatacttc 1761001 ccccatacct ttttgcccga attaagattg gttggttata ttggttttga aagcgaaagt 1761061 caggacctcc ccagcttacc gtcgcatccc gtccgggcgg tacatatggt acacttctag 1761121 tatgagaata gcgctgaacg atctgcagtc ctgcacgatc tactgcatta aatagagttg 1761181 aggacacctg acaaattcct cctcctacac cttcagacaa ctcccctttt acaataatgg 1761241 gtgcactttt atatcctttg ttccgagttc tcattcccac aacttggtta aacgaaaacg 1761301 tctcattagg gaaaacaacg tgattgtcga ttgcttttgc agaaagagaa atattgtgtg 1761361 aacggctttt attgcttgag ttaaaatacg tcacgtactg accaagctgc tgcgtactga 1761421 tgtgagctag cagctcgctg tcaactttcg gataaatgtt catttccggc acttctatct 1761481 tggagggacc ttgcccataa aaatacgcat aaaacttttc cataaacgcc tgttgataca 1761541 gtttgtagcc aaccctgccc gggacgatgc ttccatgatc gttaaggaca gcatttatcg 1761601 gctcacggta cactttctga tcaagctgtt tgatgaattt actgtatttt tcatagtcaa 1761661 ccattggagt gccgggaaga ggcattgtaa agtcttcacg gttaacagtg gcaatcgtcc 1761721 gtccttgctg tgtgaccgtt aaactgtcct gcggctcact cggctgagcc aataaaaaaa 1761781 gaccagtgat caaaatttgt atcataagtc ggtttacctc ccaatcatta gtatgaacag 1761841 ccgcttatcc tttgatgtat ttcttcccat cgtttgtttg aatctttaga cgttgataaa 1761901 aaccttcata aaagagctta gctttatgtt cacaccgatc cctgagctca ctgaggcaca 1761961 cggttcattc agtcggcaag tttgaagtag ttcagcatct cccagtgatg agggatgctt 1762021 ttttgtcttg tcaaaaatga aaagggtctc ctataacaac aaaaaatcaa tccatttcaa 1762081 tattttttta ttgagaaacg ataaattttt tgttacattc aattagacaa caaataaatg 1762141 aggtgcttgt tatgaatcga atgtcgacaa tttttttaaa gatagctttg gttcttattg 1762201 gaattccaat tcttgcttta tgcatttttt tagtgcctaa ggtagccaac tattcagcag 1762261 aattatttcc aaatatcgct tatataaaat atctcgtttt catctatttg tatgtaacgg 1762321 cgataccttt ttactttgct ctttatcaag cgttcaaact tttaagctat attgacaaaa 1762381 acaaagcttt ctcgggtttg tctgtaagag ctttgaagaa tataaaatat tgcgcagtca 1762441 ctatcagtat cttttacgca gcaggcatgc ctgtctttta tctgatggcc gagatagacg 1762501 acgccccggg tatcattgtg atcggattgg ttattatttt tgcttcaatg gtgattgcgg 1762561 tctttgctgc tgttcttcaa aaactgttaa aagaagcgat tgatataaaa tcagaaaatg 1762621 acttaacggt ctgaggtgat gacatggcga ttattatcaa cattgatgtg atgcttgcta 1762681 agaggaaaat gagcgtaaca gagctttcag agagagttgg catcaccatg gctaatcttt 1762741 cgatattaaa aaacggaaaa gcaaaggcta ttcgattatc aactttagaa gcgatttgca 1762801 aggctttaga atgtcagccc ggggatatat tggaataccg aagtgatgaa gacacaggat 1762861 tcgtaaagaa aaaatatgaa ggatcaacag aaaaataaag tgattggcgg tgagcttatg 1762921 gacataaact tatatccatc tagctgctat actaagcgtc cctttcatac acgaagaaca 1762981 caactatgga ggaggcatac atcatgagag ccataaaaca aatcgtccat tttggctggg 1763041 aacaagccct ttcatgtttg tttcctgccg ttatttttgc ctctttggct attacgcaaa 1763101 tcatcccact gcccttcttg ccgcggtatg actggctgct cattatctgc gttctcatgc 1763161 aattgtggat ggtgcgttcc ggtcttgaga cacgggatga attaaaagtg atcacattat 1763221 tccaccttat tgggcttgct ctggaacttt ttaaagtcca tatgggctcc tggtcttatc 1763281 cagaagaagg atactccaaa atatttggag tacctttgta tagcggcttt atgtacgcaa 1763341 gtgtagccag ttatttgtgc caggcatgga gaaggcttaa ggttgaactg gttaagtggc 1763401 cgtctttttt tgcagttgtt ccgcttgccg cagcgattta tttgaatttt ttcacccacc 1763461 atttttctat agacattcga tggtggttat cagggcttgt catcattgtc ttttggcaaa 1763521 catgggttac atacgaggtg aatggagctc gttaccgtat gccgctcgca ctttctttta 1763581 tactcatcgg attttttata tggatagcgg aaaatatcgc tacgtttttt ggagcttgga 1763641 aatatccaaa ccaaatcgat acatggagtc tcgtacacct tggaaaggta agttcatggc 1763701 tcttgctagt gattgttagc tttcttatag tagcatcatt aaaacaagtt aaggagcaga 1763761 gtcccacaaa ggcagagatg gatgaatctt tttcttagca tacgcataca agctcccaaa 1763821 tagagtgaaa agcaacgttc aaatggttgc ttttttcttt tatgtaactc tgccggtgag 1763881 tattcatctt cttcaaattt catcgcaaca cgataactga ttcagattac aactgctttc 1763941 aacactttga caaactcatg cgccgccggc gttatctctt caaatgaatg tgcgatgacg 1764001 ccaatatcgc gtgtgaccct aggaaagatg tcctttttaa tcaattgatg cgggacggat 1764061 gaaagtgtaa agtttgaaat gatgccgata cccaagttat ttttgaccat attaatcaag 1764121 gtttcggcat tttgcacagt taagttttcc tttaattcga tgttgtattg cgaaaatgcg 1764181 tttgacatcg cgatttcatg accgccttta caaaaaatga ggtcatcttg atatgtttca 1764241 aggtcgacat gcttttcaag ttttaattcg tcacgctgcg gcgggatgac ggccaccata 1764301 tagtcgttac acaatagctg attttcaaac ggttcaaatg gagatgctgc gatcccgata 1764361 tcaaccgtcc gatcttcaac ccatcctttt atttggtcag aggttccttc gatcaattct 1764421 atgcggatca gcgggtagtt tgatctgaat gccgcaatcg cctgtggcat gatatttgtt 1764481 gaaactgcag gaaatgaacc aattttcacc ttcccgttta acagcttgtt ttcccggttg 1764541 gctacttgat atattttgct ttcaattccc ttcatttgcc tcgccagcag caatatttct 1764601 tttccgatgt cagtcagcat taaaccatga tgtttatccc tgatcaataa tttgagctgc 1764661 agtgagctct ccaggttttt tatcgcttta cttaccgccg gctgagagat gaacaattct 1764721 tttgccgctt ctgtaatatt taatttctcc ccaactttta caaatatgtg aagatggttc 1764781 atgttcataa ccatttggtt atacccccaa taataaaaat gtatttcagt tatacataaa 1764841 tgtaacatat gatagaaacc agcacgatat tttaacaaga aaggcggctt cattatggta 1764901 aaagttatgc tgggaatcat atctgtcaca cttatttggg gttatacttg ggttgcgatg 1764961 aaagtaggaa ttcatgacat ccccccgctt ttattttcgg gtttgcgcct gttcatcgga 1765021 gcagttcctt tatttctcat tctcttcatc caaagaaaaa agctttcaat tcaaaaagaa 1765081 catctcaaaa gctatatcat catgagcctg ttgatggggc tgggctatat ggggattttg 1765141 acgtatggaa tgcagtttgt cgattcaggg aaaacctctg ttttggtata tacaatgcct 1765201 atatttgtta cggtgatcag ccatttttca ttaaacgaga aaatgaatgt gtataaaacg 1765261 atgggactgg tctgcggcct cttcggactg ttatttatat ttggaaagga aatgctcaat 1765321 atcgatcaaa gcgctttatt tggggagctg tgcgtacttg tggcagcgct tagctgggga 1765381 atcgcgaatg tgttcagcaa gctacaattc aagcatatcg atattattca catgaatgcc 1765441 tggcacctta tgatgggagc cgtcatgtta ttggtgtttt cctttatatt tgaggcggtc 1765501 ccttcagccg agtggacata tcaggcggtg tggtcattgc tgtttaatgg cttgctttcc 1765561 accggcttta cctttgtcgt atggttttgg gtgctcaatc aaatccaagc gtcaaaagca 1765621 tccatggcat taatgtttgt tcccgtattg gccctattct ttggatggct gcaattgcac 1765681 gaacagatca ccatcaatat tatcctcggc gcactgctga tatgctgcgg gatttttatg 1765741 aatacattta cattttcacg acggaaagtg tgaatgatat acatttcccc tgtcatttgg 1765801 gcttcatgtg acaggagaag actattacga gaaagtcttc tagaatcctg acgacagcct 1765861 attaaacaat gaaaaaagct aatgtctgca tgtagacatt agcttggctg gcgtttaggc 1765921 tggtgagaat ccagatactt ttttattacc attctggctg atcaaactga aaaccgtata 1765981 gaccttttac tttaacatct ccgcaatctg gatcttttgt caaaatcaaa taatgagtct 1766041 tataaggcat cgtctcaact cgatcagttg cactaaaatc aaaatgatcc cccgagaagt 1766101 ttttttcact aacggttatt tcatatcctg acaaagtcat tcgcatgatt cttgcgttaa 1766161 ttgtacatcc ttcagtatcg aaaatggtga atctgtaccc aaagtgagat gtccaatggt 1766221 ttgaatttag gtcatcagac ttcataaacc atttttcatt ctctgtcatt gtaaaactca 1766281 ctttctcctc atctttcacg ataacggccg aagcttcccc tacatggata gtcaaagcca 1766341 aaagaaatgt aaaagctaac atcaacatct ttttcaaaag agttcctccc gatatctttt 1766401 acttcaatat attggaaggg tcttttctga tcaagacagt cttctccaaa tgaatcttta 1766461 gcaccatgaa atgagcctta ataagaacag ttttaaccca aatcaacctc tattcgaaat 1766521 aaggcttacc aatctatatt ctttttaaaa gtttctgcat ttctttattt agctcctaga 1766581 cacatataaa aaatgctcct ataagttcag gagcactaca aaaaactgct aaagtgtttt 1766641 ctatcgattt attgtattca ttagctcaaa gaaatattca ggcttttgag tcttatttag 1766701 cttataccat gaacgcaatg tatctggtgc aaatacatct aattttttca atacttctac 1766761 cgcaaattcc agaggagcaa ttcctgatgc agtaaccaaa ttttcatcag atactgcagg 1766821 ccccttttca tagaatgttt ctcctttgta attagggcag accatattca tatagtcgag 1766881 gtcattgctt gtgtgctttc tcgaatttaa gtatccttca ttcgcgaggc ccaaggttgc 1766941 cccacaaatt gcagcaatag tcgtgccgag ctttaaagcg tcgccaactt ttttcaagat 1767001 cggctgatga atatcttctc cccaagtgtt tcctccgggt aaaatgataa gatcttgact 1767061 cccaagagta cattcgtcaa gagaaatatc tggttttatg cttaatcctc ccaacgtagt 1767121 tatcatttct ttattaaccc ctactgtaac tacttttaaa gatgctgcat cttgtttaaa 1767181 gtatctccct gagtttagtt ccgcaattaa atatccatat tcccagtctg acattgtgtg 1767241 aaatacgtag agataaactt ttctcgtttg catccaataa cactccaatc acaattgata 1767301 aagctttcta atagatgact ttgctgacag tcattgtcag cttttttgtt gattctattc 1767361 ttatgccctt gttctcccaa cttataaaaa tataagatca attgattcta tgtttactag 1767421 cgcaaagggg tttgttacac taactgtcat gggaaacatt tcaaaggtaa tacaaaatca 1767481 tttgaatgag gaggcctgat gaagttgaaa actaaagcgt caataaaatt cggaatatgt 1767541 gttgggcttt tatgtttaag cattactggt ttcacacctt ttttcaactc aacacatgcc 1767601 gaagcaaaat ccatagaaga cacaaacatg gcaagctgta taacgaataa aaaatttgtt 1767661 caacttgaga aaaaatttga tgccaggctt ggtgtttatg caattgatat aggttcaaac 1767721 aagacaatcg cctatcggcc gaatgaacga tttgcttacg catcaaccta taaagttcta 1767781 gccgcagctg ctgtcctgaa gaaaaactca attgaaaaac ttaatgaagt catccactac 1767841 agcaaggacg atcttgttac atattctcca atcacagaga aacacctaga tacaggcatg 1767901 agcctaaaag aaatctcgga agcggctatc cgttacagcg ataataccgc tgggaacatc 1767961 ttgttgcaac agcttggcgg ccctaaaggt tttgaaaagt cactgaaaca gattggggat 1768021 catgtaacga aagctaaacg attcgagacg gatctaaact ctgcgattcc tggtgatatt 1768081 cgtgacacca gcaccgcaaa agcactggca accgatctta aagccttcac tttagataac 1768141 actctcacga ctgacaaacg catgatctta accgattgga tgcgaggcaa tgctactggt 1768201 gacgaactga ttcgggcagg cgctccaata ggatgggaag tcggcgataa atccggagcc 1768261 ggaagttacg ggacacgaaa cgacattgct atcgtttggc cgccaaacag agctcctatt 1768321 gttgtggcaa ttctgtcaaa ccgctttacg aaagatgcta attatgataa tgctcttatc 1768381 gctgaggctg caaaagtcgt ccttaacgat ctcaaataat atgtttagcc ttttgccaca 1768441 aaggaaaaga cattactttt ttaacttcta ccgttcattt tttgatgaac ggttctttca 1768501 taagacctct agaatcatat atttaaacac cacaaaatta aacattatta taattaacag 1768561 caagttttca ttttatggaa caagtaaagt ttgaatctga caagaattaa gactaagcac 1768621 cctaaaatcc gttttctttt cttccaagaa tatactcctt agtgcaagcc attataaaga 1768681 tacaagtgaa catacaatgc agacaactct cttaagtctc ttattctgtg accaatttgt 1768741 aatactcatg aatatccgga ctcacttcca atatttcgtc tcgttcgaag acactaacat 1768801 atcaaaccac ttgaattaac ataactgaac ttgatattgg tcactggcag tttcaatgca 1768861 atagaacaac atttgttgtc tcagaggtta tctatatgag aattcaacaa tttttttata 1768921 ataattcata tttttgtatc gttgcacttg gtggatttga ctcttttcgt gtatggaacc 1768981 acacttttat tttttcacct cttttgagat catctgtgtt atcaatctca cttaatccta 1769041 caattactat gttattttta aacttgttca taagttgtcc ttcagaaaga ttgtaatctt 1769101 cttttcctgg agcttttgta tcggtaatga gaattgccct ttcattgtct ttaagcacga 1769161 catagcctac taggctctgc atctttgttt cgtctccgtt ttgttcattt ttattgcagc 1769221 ctgcaaggaa aataatgagc ataatgagca ctatcaagct tactccgatt ttaggcatct 1769281 ttcttcctcc tctttaaact catctttaaa ataaacaaca ggatatcacc caacccatct 1769341 acttcttttt gcaattcata acagcagcat actcattctc caattcctca accttctttt 1769401 tattctttct caaatatttg catgtggtag ccctcgatat tatccgctta ctcatttttg 1769461 cgctttcaaa tatattattg aaggccgctt ctttctggat tccagcataa atatacttat 1769521 ccttactgtc gtttactatc gcaacttcca ttaaaatcga gatttttact ttttttatga 1769581 tccattattc acttccaaaa taacttccaa ttacaacata atatatgtat aaattgtaaa 1769641 tggagttgat gtaattgaag attaggaaaa tcttattgag ttctgcttta tcctttggca 1769701 tgctaatatc cgcggttccc gcattggctg ctggcacttc gtctgaggtt gcagtaaaaa 1769761 atgaagaata tgattatgac actatatacc gcattagtcc tctgccaatg gacttccagc 1769821 caacaataga atacaacggt tatacttata cgcttacacg tcattatttt gattactcaa 1769881 tcgggtttta cacggctatt tatacaaaag ttgtttaaac ttataaagga gctttttagc 1769941 tcctttttct cttgttttaa gcaaggtatt tctttctatg tggtccccta tcaaatacaa 1770001 catcaacatt ctccagttct ctttgacacg aacaaaatct aaagtttggt tttaaatgct 1770061 ggtaataaaa aattcacttt aaagaagtgc cgcccgcaaa atacggcttt tgtacactac 1770121 gccaatttta tattgaaaag ccagacctcc tcaaagaggt tccagctttt cttaatgtgc 1770181 tatcgatctt cgttagttca acgggaactt tatcattcgg tacaaatgca gcctcccaac 1770241 ttctagttag ggctgatggc ggaatatctg acggttctct acacacatca gacattagaa 1770301 gatttcaatg tagccttctg taccatgaac gcgaattcgt tgcccatctt ttatcagctt 1770361 ggcagcattt tcaacgccaa caactgcagg taagccatat tcacgggcta taacagctcc 1770421 atgggtcatc agccccccaa cttcggtgac taggcctttt atggatacaa acaatggtgt 1770481 ccagcttgga tcggtaaagg aggtaactaa tatatctcca tcttctaaat ccgcatcttc 1770541 catgtttaaa atgacacgcg ctcgcccctc tataactccg gaggaaacag gtagacctac 1770601 aatcgctccg gctgggagat tttctcgttt atactcacct gtaacgattt caccatcaga 1770661 cgtgataaca cgtggtggag atagtttttc atataatgtg tactcgtctt ttcgtgtact 1770721 gatgatttga taatccagtt tatgtgtgcg cacgacttcg tgaagttctt caaaagtgag 1770781 atagtatata tcttcttttt catgaataac gcccgcttct atgagttgtt cggcttcttt 1770841 cagtaaagcc tgcttataaa cgaagtatcg attaaccatg ccgtattttg gatattccct 1770901 aaacccgctg aaattccgga tgatatctat cgctcgtttt gtttctttgg ctttttgttc 1770961 accatccggt aattgcttca atcgatctaa taactcttgt tctttcttca aagcttcctg 1771021 tcgcccttgc tcaaatttcc gatggccgac attaggctca aaatttttaa tattattaag 1771081 aatcattggg acaagtgtag ttggtttttc gctccatcga gttcttgtga tatcaatctc 1771141 tccggtacat cgcattccgt atttgctgag ataatcatag atcgcgtctc gggttttgct 1771201 tccgccatca aacttagcca gttcatccaa aaagttatca tcttttacat gttgtaagta 1771261 atcaattacc tctggataag gacgaatcac atctgcgacg tctaatagcg caagacccat 1771321 ttctgaagta atattatggg gtacagattg agaaagcgta tctgctgcgt ttttttcacc 1771381 taaccactcg ttcatttttt cgttaatcca taatgaagca ttcatagcag ttcgaattag 1771441 aaccgaactt tttgggttaa ataaaatctt ctttaattcc tgaatatctt ccagaataaa 1771501 acgaaataaa tctgatcctg atttcgtttg gatgttttgt tttaactctt ctatcgatgt 1771561 ttgactgctc tcaatcaaat cagacacgat tgtcggatcg ttttcaactt gagccggcat 1771621 atctgcattg cctctgctgg gatttggtgc tgttttatca tttggtatcg actttatgaa 1771681 atctcgtcgc tttattatgg tcataagtgc gtcttttaag agctgatcgt gctgccccat 1771741 gccttttaag aaaacttctc tgctgtcagg ggatgccaga tgatgtgtga catcaacaaa 1771801 tagccttcca ccggctttac gcatgggtgc aacagtcgtc aacagaaaaa aagacaatcc 1771861 cagtggtttt atgggatccg tcatcatttg ttgatgacca acagaaatat agacgtgatt 1771921 ttcttggtca ctcgcttcag ggatggggaa taaagtagtg attggacgac tctgtacaat 1771981 ataaaaagta tcgcgggcca aacaccattc gatatcttgc ggctggccga aatgagcttc 1772041 gatctgtctt ccaatgcgtg ccagctgtaa aatttgttca tcagtcagtg tttgagcctt 1772101 ttgctgatca gaatcgatct gctgtgtttc tgttccgcct tcttttcgtc cgtagatagc 1772161 cattttttta gttgctattc tcttatcgat gatttgccca tcctgtactt taaaacaatc 1772221 ggcagatacc aagccagaaa ccagtgcttc accaagtcca aaaccggcat cgatggataa 1772281 cacctttcgg ttggaggtaa tcggatcagc ggtaaataaa atccccgaag cctgagggaa 1772341 aaccatcctt tgaacgataa cggataaata gacttggctg tggtcaaatc cattttgcat 1772401 acggtaaata accgcgcgat ccgtaaatag ggacgcccag catttactga tatgctgcaa 1772461 gattgcatcg acgccggtaa tatttaaata ggtgtcttgt tgaccggcaa aagaagcatg 1772521 tggtaaatcc tcagcagtcg cactagaacg cacggcatag gcatgttcct cgccaaactg 1772581 ggagagatat tgagccactg ctttcacaac atcggaagga atgtctactt ccataatgat 1772641 ttgccgaatc ttccggctga tgttaccaat ctgatctcgg tcctcaactt ttagcatggt 1772701 caattgatcc aacaacactt gtaacgtttc gttttgttcg atggcttttt gatatcctac 1772761 tgttgtgaca caaaatcctt ctggtacttg tataccttga atttttgata attcccctaa 1772821 atgtaaccct tttcctccaa cgagcgaaag ctgtgttttt tcaatttcat gtaaaccgag 1772881 aaccaaagaa ctcattctac atctcccctt caaaaaaaaa tattgacaag agcttcctag 1772941 caggatataa taaaattata agatggatat ctataacttt ttaactagaa agcgcacgta 1773001 gtgtgattat atcaccgtgt ctgtttttgt gcaatataaa aagaacctgg gaaatttcac 1773061 caggttcttt tcttaatttc catagctagt cgcattaaaa aacttggttt gagctgattc 1773121 aatcctctaa ggaaatccta aagttgggtt ctttttgaac ttacttgctt tgttcgtaga 1773181 gtccccattc ataaattgga ctttttgttc ttaacagtcc cacctttaac tagtataaag 1773241 ttatgaggat ctggttaact actagatatt tttattttga ataaggctta tgtttgataa 1773301 agaagggtta tgtaaaggtg tctgttgtga gcaagcgctg actacaaaaa attgatagca 1773361 ttctcattta aataccattc tattaaccta tagggaaagt tttaaaacca gatggagaat 1773421 accctacctc cagcaattcc aaggccgttc acctagtaga aaacaacctt taaccattac 1773481 taacgatttt aataatcatt gattataaaa cttctcaagg aacgatcagc agcccgttag 1773541 ctacccctga ttaaggatga tctgttacca cactgttacg ttagaacttc cactactttg 1773601 atatccttct gtcgccatga cttggtaagc ccaattactg cccagattca ttccatggct 1773661 cttccatgcg ttcacatgat tgctgaaagt gattgtagcg ttgcttccgg ttggtctctt 1773721 cgactggcga acactccagt actgcgtaaa agtagtgcga tcgccatcaa tggaaggtgc 1773781 gttataacgt gtagttgtat atatgtcata tgtaccccca tcacttttta cagtaccttt 1773841 atacgttcca gtaggtctat aagtacccca tgaatccact acataatatt ctatgagagg 1773901 tgatctcgtc caaccatata aagttaaata tccattgcca ttcggcgccc aaactccggc 1773961 attatagttt atcgtcctaa atggcgaacc tgtagtccaa cctttaccaa caacaaaatt 1774021 tccggtatta gaccaattaa cactgtaatt cccgccagac ccattgacag cgtttactat 1774081 accgccccca tcagtccaat tttgccagta gtctgtgcta gctgcagagg cggttgccga 1774141 aaacaagcta atactcatta aagctgccga taatccaact aagaaattct ttttaaactt 1774201 aaacatatgt tacctcctat aatatttttt ccgactttga ggtagcactc gtatacattt 1774261 aaaacattct taattactaa cgccaaagct tttgatcgtc cccttcagta taataccacg 1774321 aattcatgag caaatattaa aagtatttgt aattcaatta caaataccta gaaacacatt 1774381 ataagtggtc ttcttccacc atatcctgat ccgagctcga tgtacatgcc tttacggcac 1774441 acacgaatgt ggcgtgtggt gcatcgcctc aatacgcaaa gacgtttgcc ttaggcaaac 1774501 gtcttttttt gcgttatccg atttttgtgc cgtttgggac aggctgatcc ggctgcaaaa 1774561 ggacgacgtc gccctggccg ggtatgccgc cgaggaccaa gacttccgat ttaaatccgg 1774621 cgatccggcg gggcggaaag ttcacgactg ctatgacttg cttgttgatg agaccttccg 1774681 gcttgtaacg cttcgtgatt tgtgcgctcg attgttttat gccgatttca gtcccaaaat 1774741 ctatcacaag cttgattgcc ggtactcttg cttcaggaaa ttcttccgct tttacaattg 1774801 ttcccgttct gatatccaat ttctcaaagt catcaataac tgccatatca ataactcctt 1774861 tttctcctat tgtaaaggag atatacaata ttcttttaac taaagagcca tcatttttta 1774921 tccgaatata aggtgtttcg atacaggcgg ggcggcattc ctgtgctttt cgtgaaccat 1774981 cttgtaaaag aagaaaggtt ttgaaagccc agcgcctcgc tcacgacggt aagagtttca 1775041 tttctctcca tcagcattct ttttgcttcc tcaaggcgaa ggtcggcaat atagttctgc 1775101 ggggacttcc ctgtctgttt tttgaaccag cttgaatagt aagctgggtg ataatgctcg 1775161 atttctgcca gcttcttaat cgtcagccgc tcaaataaat ggctgtgaat gtatgcaatt 1775221 gaggcatagc tatgggattg aagcttttct tttatgtatt gtactagcat atgaagcgag 1775281 ttggctgttc cggcctttgc ttcctctgtc agcaagtacc tgatcgaaga ccagaaagga 1775341 tcgagggcag cttcaattcc tgatcctgca cgatactcat caattttcat tgcatgaagc 1775401 ggaacatcca gtacaagaca ttcatttctt ccgatagaac ggaagcgatg ctcgcactgc 1775461 ggcggaatat ataaaaaatg atccggattt aatttcacct ggcgcccctc agtctcaaga 1775521 tcaatactcc cttcaagcgg aaaaagaaat tggctgtacg cgtgcttatg tgaatgatat 1775581 agccgtgtgt atgtccgttt ttcgcaaatt atctcttgaa gcgagtccat tagcaaaccc 1775641 cttcctttgg tcatctttta atccggtaat ggtgttccga tataggcgaa aagccgattt 1775701 ttccatataa agaaactgcc gccagatttt ctttcatcac ttgtaaaaac atgcgttccg 1775761 ctccgttgtt ttttgcccat tcagtcaaca ccctgatcac ttgggttcct gccccttttc 1775821 ctctgtgctc ctcagctaca acgatattac taagtccgcc ataaccatca atgacagaaa 1775881 ccgtgccaag cgctgtcagg ctttctttgt catacatctt gaaaaaagtt ttacacggcg 1775941 gcatgcgttc gaatatgtgt ttgtaacctt tgtgacgctc gggtgaaaac ccttctaatt 1776001 gaataaattc atctatccaa acagatgatg gctcttgttc ccacttgtat gtaaatcggc 1776061 tgttgtcatt tgttcggctc ataattgacc ggcacaacgc tgtcatctgg aagcactcgt 1776121 ctaccttttc ataacggctg tctgccaatg cgtcatcaag ccctttcggt gatgcgttgc 1776181 taatatgaaa acaaacaggt aagcctaaac tttgataaaa aagttcggcc tctagctgaa 1776241 aatccccttc aggcatatcc gcagacgtcc atacgctatt tgcccttttg gttacgccaa 1776301 aattcgctct gagaagccat ttccctatgc ttttttgaaa ataagccggc catgaagctg 1776361 ccgctaatcg ttcaatcttg cgaatgtcat ccattgcata atgcctctcc cctatgtata 1776421 ctcccttgat attatacaat attcagaaat ataagacatc catttatttg tttacataat 1776481 atttttattg tttattaata atcctgacaa aaatgtccga attgaaaatg acaggctttc 1776541 taaaatgtcc tcctcacgtt caaatgcttc ttttgcgatt aaaacagtaa agccatgcag 1776601 cagacttctg agcccccttg tcgcatgaat ggcagtcttt tcacttgcat agccgttttc 1776661 aatgagcagc ttcgtcacaa gacagacaat ttggtcagag acgatttccg tccgtttgtc 1776721 gtgaacctta agaagagccg cttcataata tccgggattt tcaattgcaa aatcaacata 1776781 tgcatgagct aaagaaagca tcgcggaatc tccctttcgt tcggttacgg agtccgccat 1776841 ttgatcaaaa agctttgtca gtcctctgac agcaagttct gctctgatcg cttgcagccc 1776901 gttgatatgg ttatacaatg acggggggcg aacattcatt tttttagaaa gtgcagcaag 1776961 tgagacacca tttacccctt cctgatcggc aatctctgct gcagcgtcta caatcatttt 1777021 ttgggtcaaa cctattctcg gtgacatgct catcatcctt tctttgcttt ttggatcgcc 1777081 tgtctcatcc gctctgaagg tgatcgcagg aattttccat gtccgacagc gagacaggaa 1777141 ggcgccttat cggcgagcaa ttgtgcactt ttgatggcct cctccttatt ccatgtggcg 1777201 aaagcgggaa aaggaaacgc ccattttatc tgacctgata cagcgattcc tccgcgcaac 1777261 tgaaacgcat ctcctgctat taaagtgccg tttcttgtat caagaaatga catgctgccc 1777321 ggtgtatggc ccggtgttgg aatggcaagc agagaaccaa ttgtttcacc gcccgtcagc 1777381 agttggtgag gctttgtttg tatgtgtttc ggaatacctc cttttatagg cgtctgcggc 1777441 tcatcttgcc gcaaagatgt gtcaccttgg agcaagaatg aatcccgttc cgagatcatg 1777501 acctttgcat gcggaaatgt ttgtgccaat gtatccagtg atccgacatg gtccccatgt 1777561 gcatgagtca gtaaaatatg ctgaagcggt tttccaagct gattcacagc ttgaataatc 1777621 cctttatagc tgcctggcag tgcggcatca ataagggtga cttcgttttc ttcctctact 1777681 aaatagcaat taaccggaaa caatgctgga aaaaaagtca gctgccaaac cgtttggtac 1777741 tgagtaattc tcatcttttt attcctccta acaaaaacta atggtgttag ttttattatt 1777801 aactaacacc attagttttt caagagttta ttattttttt atcgctacat aaatgttaac 1777861 ttgtgctcgc tgtggcactg cggcattttg atcatacatc tcaaagtcac ctgtaaacgt 1777921 gcgcagatgc cgcttatccc aagtccaaat ttccttccac gtttcaagca caatctcttc 1777981 aataggaccg attctggaag tgaaaacggc gtaagcggaa gccggcaaat caatattttc 1778041 atatggtccc ggaagaatgt cgtcgtattc ctgaaacgtt ccgactgaaa acgtataaaa 1778101 cccattcgtc tcttgttcat aattcgaata taaggcaata atgctcttgt ctttttcagc 1778161 ctgtgataaa agagcgctca tatcctgctt ccataattga tcccacagtg ccggaatcct 1778221 cctttcttcc gtcatttcca gtgcgttgct tgtccgttgt gatagtccgg caaatcgttt 1778281 caggtctaag tgtgttatat gtgaaaagcc catacgatct cctccttttt ttaagattat 1778341 agacaaagaa acctgacagc agtgtgtcag gtttcatata ttttttgcat gtgatgaatg 1778401 gtttctttta ctttatccct tatatgaaga ggctgcagaa cctcaatatc ctttccgaac 1778461 tggagcaaaa aaccgatcag ccattgatct tctggaagtg aaatcaccgc ctggcagatt 1778521 tcatcttcct cacaacagtg aaggacatca tatccgaacc attcacctat acgctgacgt 1778581 gctgacggct gaacaagaat aaccaattca gttaaacggt ccttttggta ccaactctta 1778641 tcccatggca aagtgtccag ctgaatgtct tttctgataa atgtctgatg taagatggcc 1778701 agatctttca tccggttcag tttaaaaaag cgaaaatcat ttcttaccag gcagtaggca 1778761 tataaatacc agtgccccgc cttgcaaacc aatgtataag gttcagtttc ccgaagtagt 1778821 gtttccccgc ttgcgcttgt atatgtaaaa gatatcgtta acaaccgatc gatggcagcg 1778881 ctgattttct cgcgcagcgt cttttgatcc tcagtatggc cccaagccgt catgtcaata 1778941 aaccattttt ctgtttggtg cttaaatgct tgagtagatt gctcaggtat aaggtgtttg 1779001 attttttgat aggctgtgct gtgagaaacg ggttcataca tagatgaaac gctttgcaaa 1779061 gcggaagcaa ttgcaaacaa ttcctcctcc ttcagccact ctctttcaag ccgatacgtt 1779121 tccatgatgc caattccgcc cccggaaccc tgtgaggtca caatcggaat accagcccta 1779181 ttgatcgtct caatatcacg gtaaattgtt ctgacagata cttcaaacag ctcagcaagc 1779241 tctgcagcct gcacttgttt tttgctgatc aataacacaa ccatcgctaa caaacgttcc 1779301 agtttcattc tgcgcacctt ttcttcttgt attttccaac aaaacaatca taacattttg 1779361 ataaagcttg ggcatatcta ttatgcggcg gaatacacct cgcatatgct atgaaaacag 1779421 gggtttcccc ttcttttttg tgttcagtat ttatttcagc tactatttcc gaccggataa 1779481 gcatacactt ctcaacggag gggatttcac atcatgcatc ttacacttca gagcgtttat 1779541 cctgccataa tcatcatctt ttttctgtat aaaaaaatta aaaggtccat cggataccag 1779601 ccgctgaagc cccgctggct gttcacccgt atcattcttt tctcgctgtt tgcttttgga 1779661 ctttcaatct tcagcgccat tcaccctttt ttatatggat atctcatttt gggcattctt 1779721 ggcggatggc tccttgtctt tttcgctaag aaaaacatct cttttgaaaa acgcagagga 1779781 aagatctatt ttcggactca tatttgggta gaggtgattc tcttaacttt atttctatca 1779841 agatttctgt atcgagtgac ggagctttat cttacctcac ctgatctaaa ccgccttgga 1779901 tcatacagtc agtcaatcgg aacggaccct ctgacaattg gcgtctgttt tctgatagcc 1779961 gtttattata tcggtttttc ttcttttatc atcaagctca gcagaaacga acttgaacag 1780021 cacgaataca ataaagaaaa agacatcctt gcccgctaac agcgagttaa gcaaggatgt 1780081 ctttttcaat catgctgtgt atgatggatc atttgctgaa gaacatctaa aacatgttca 1780141 tcctccggag agtaataaat cgatgttcct tctctgcgcg atttgacaag ccggagattt 1780201 tttaaaaatc taagctggtg ggacacagtg gattgcagta aattcagctt ttctgcaatt 1780261 ccgtttactg catgctcacc ttgggacaat aaatggagaa ttctgattcg ggtaggatct 1780321 gaaagcgctt tgaatgtttg cgcgactaga aacagcgtct cctcgtccag atcagcagcc 1780381 gattgttccg tttctctaaa ttcagtcata tgtatcacct ttctttattc atagttttat 1780441 cttataacaa atgcgcttga gtgcaaacca gcctgcttgt attccatttc aatctcatag 1780501 tttaaattta tgtttcaaat caggttttta cttggtctga tataccctct tatgtcataa 1780561 taaaaaaggt catactgctc caaacattga gggtgaaaca cagtgaagaa aaagagaaaa 1780621 ggctgtttcg ctgctgcggg ttttatgatg atttttgtct ttgtcatcgc ctctttttta 1780681 ttggtcctgc tttttttcaa ccgggattta atcaaaaaac ttccgatcga tacgaaaacg 1780741 attgttttgg aacgtttaac cgattacaaa cccttggtgg aagaagagct tgaaagccaa 1780801 ggactctcta attatacatc actcatatta ggcatgatgt atcaggagtc aaaaggaaaa 1780861 ggcaatgatc ccatgcagtc ctctgaatct ctggggttaa aacgcaatga gataacagac 1780921 cctcaactca gtgttaaaca aggcatcaag caatttaccc tcatgtacaa gaccggtaag 1780981 gaaaaaggcg tggatttgga taccattatt caaagctaca acatgggggc aggttacatt 1781041 gattttgtag ctgaacatgg aggaacgcat actgaggaat tggcaaaaca atactccgag 1781101 cagcaagtca aaaaaaatcc tgatctgtat acttgcgggg gaaatgcgaa aaatttccgc 1781161 tatccgtatt gctacggtga ttatacgtat gcagaaaaag taaaagaaaa aacaaaaact 1781221 gttgaagaat ctttgcaggt tgcaacactt gaaaccatgg aatccaaggc tcatgaataa 1781281 gagtctatca atttactgac aaaagcccaa aaatgaattt gggcttttgc catgtttaca 1781341 cgtaaaaaaa gccatactga gtatggcttt taataatacg gtgaaatcat caaatataca 1781401 ataacgcctg taaggcttac atacagccat agaggcattg tccatctcgc aattttttta 1781461 tggcgctcca cctgcatgct gaagcctctg atcagcgtaa acagcgcaag cggcacaata 1781521 attgcagaaa ggcagatatg tgtaattaaa ataaagaaat aaatcgggcg cataatacct 1781581 tctccgccat agagcgtgtt ttccgcaatc gagtggtacg tcacatagca aatcaaaaat 1781641 agtaatgttg ttgtgaacgc agccaaaata aagcgtttgt gagctttgat atttttctgt 1781701 ttaatcataa tcagcgcggc caataagaag ataaacgtaa agctattgaa tatcgcattc 1781761 agcattggca aaatgtgaat attcgcatgg ctgaactgat ctaatttagg cataaaaaac 1781821 agcactgcga ttaaaccgtt aatcagaact gtcagcgtaa ggacaatccc cgtgtaattt 1781881 ttcggtttat tttctgtttg gttcatttgg tgacctctcc taatttgtac tggctatcca 1781941 aatcgtatgc aaattcaaag aagatgtcaa cggtttcgat tgcttcgtca gaaattagac 1782001 acacttcaaa ggccggaggc tattagcccc ggcctgttag gtttacgcct cttttatcaa 1782061 atgttcaatg accttatgtt cattttcatt cagcaggttc ttttgaattt tcgaatgaat 1782121 gggtttattc atatgctgat ccaagatatc ggccgtttct ttatccccgg caataaccat 1782181 tcgttcccat cttttcgcgg cagctttttg atcaaggctg gcagccagcc gcttatacag 1782241 tctcgattgg ttctctgtta catgttccct catccggttc tcttcaaatg gtggcgcttt 1782301 gtctacagcg gaatggctat tcttccaaga ctcattgatc atatcatact cataacgctc 1782361 caccgcctca atttttccta aaacagtttc aataattttc acttcatgct gctgagttaa 1782421 aataaacgcc gtacttgggt atgtctggcg caaacccttt agctgatcca ggacagctgt 1782481 ttcttcccag taaaatcttg tatctacagg gacttgaagc ttaataggtt cccatatgcc 1782541 gctgtcggaa acaaaaaaca cgagactgcg gggcatgtct tttcccattg cattcaagta 1782601 ttgattcatt ttagccctga ttccatccag acacttttcc tcctctggat cactagctgc 1782661 caaatactct tttaatcggc tgaatcctga ctttagggca atcttccatt ctcccccctg 1782721 ctgctctgga tctctcatgt ctgtattgag atacagagag agaattttat ccggcggttc 1782781 caattggaca tactgtaatt tgttaatcaa tgaatcaatc gccattccga ttcctccttt 1782841 ttcacaggtt agttttcttt ttcctctctt aaaaacgatc aaacctgact ttccgctaat 1782901 ttctagtaat aatggaattg ttgtttacaa tacgcctctc ttctaataca attggtaact 1782961 gtgtttctaa gctgtttttt gaaaggagtt tgatcttgtt tactgttaaa gaaaaaaatc 1783021 gtcaagagct tgaggaagaa ctaaatgatt tagaatttca aatttatcgc atgcaggaga 1783081 atatgaagga tttatctaaa gatgccaaag tgcttggtat tgatcaatcg aaacatgatg 1783141 agtggatgat tgtttcctcg attgatgatg gccaaacatg caaaattatg ctaactgatt 1783201 gtaaaacggc ataccgagga aaaggctgtt tttcacttgt agcgtcttac aaggacgatg 1783261 ccattcatat aggggatata aaaggccctc cgaatcacgg gtttggctcc atttgcatga 1783321 aatatttaaa agatattgca agagaccata atataccgaa agtcaccgga gacatcgcca 1783381 aacgggattg gaatcatgta gaccggctga ttcactttta tgaaaaacat cacttcaaag 1783441 tatgtatcga tcatgatacc caatccggca gcattaagtg ggttgatttg taaaaaagtc 1783501 tggaagaaag agccaagata tgctgtaatg gtataaaacc attgatggag ggttctatgt 1783561 acgcctcaaa actgaaaaag ggagacgaaa tccggatcgt gtctcccgcg accagcatgt 1783621 ctatattatc aaatgaagca aaaatccaag caaaaacggc gttagaacgc ttaggttatc 1783681 gggtaaccat cgctgaacac gcaaatgaat gtaacgaatt tgattcatcc tctatcgagt 1783741 caagagtcca tgatctgcac gctgcctttt ttgatccagg cgtcaaagcg attttaacga 1783801 cactcggagg gtttaattca aatcagctgc tgcgttatct tgattacgag aaaatcaaac 1783861 gacatccaaa aattctgtgc ggttattccg atataaccgc tctttgcaac gctatttatc 1783921 aaaaaacggg tcttgttacg tattcaggtc cccacttctc aacatttgca atgaaaaaag 1783981 gactcgatta tacagaggag tattttcttt cttgctgcgc ttcagacgat ccgtttgaaa 1784041 ttcacccctc aagtgagtgg agcgatgatc gctggttttt ggatcaagaa aacaggcgtt 1784101 tttatcctaa taacggccct gttgtaatcc aagaaggtta tgcggaaggt actttaattg 1784161 gcggaaactt atgcacgctt aatttgctgc agggaacgga gtattttccc gaaacagaac 1784221 atactatttt attgattgaa gatgattata tgtcagacat ccatatgttt gaccgcgatc 1784281 tgcaatcact catccacctc cccgcttttt cacatgtaaa ggcgattttg atcggcagat 1784341 ttcagaaagc atcaaacgta tcaatagatc ttgtaaaagc catgatcgaa acaaaaaaag 1784401 aattatccgg catcccgatc atcgcaaata taaatgccgg acatacctcg ccaattgcca 1784461 cgttccctat aggaggaaca tgcaggattg aagctatttc gggtacatca cgaatatgga 1784521 ttgataaaca ttaatcagct tgtaaatttt tttacaagct tttttagcgc aatcggctat 1784581 gcatgccgca cgagacatga caaatgtcat ataggaggca tgatgtgtgc tactacaaaa 1784641 gacttctctc attagcgtat actgaaccga gacacacaat gagaggatac ttactatgac 1784701 tgaacaaacc attgcacata aacaaaaaca gctgacaaag caagtcgctg catttgctca 1784761 gcctgaaaca aaaaacagcc tgattcagct tttaaacacg tttatcccat tcttcggcct 1784821 atggtttctt gcttatctca gcctcgatgt ctcctatctt cttacgttag cattaacggt 1784881 gattgccgca ggttttctga caagaatttt tatcatcttc catgactgct gccatcaatc 1784941 ttttttcaaa caaaaacgct ataaccacat tctcggtttt ctgacaggtg tcctgacttt 1785001 attcccgtat cttcaatggc agcacagcca ttcgattcat catgcaacta gcagcaatct 1785061 ggataaacgc ggaacaggag acatctggat gttaacagta aacgaatata aagctgcatc 1785121 cagacgaaca aagcttgcat acagacttta tagaaacccg tttatcatgt ttattctcgg 1785181 accgatttat gtttttctga tcacgaaccg ttttaacaaa aaaggcgcaa gacgcaagga 1785241 acgtgtaaac acatacctta cgaatctggc aattgtcgcg ttggctgccg cttgctgtct 1785301 gatctttggc tggcaatcgt ttttactggt gcaaggcccg atatttctga tttcaggttc 1785361 aatcggtgtt tggctgtttt atgtgcagca tacctttgaa gattcttatt ttgaagcgga 1785421 tgaaaactgg agctacgttc aggctgctgt tgaaggcagc tcattttata aactcccgaa 1785481 actgcttcaa tggctaacag gcaatattgg ttaccaccac gttcatcatt tgagtccaaa 1785541 ggtgcctaac tataagcttg aagttgctca tgaacatcac gaaccattaa aaaacgtacc 1785601 gacaatcacc ttaaaaacaa gcctgcaatc acttgcgttc cgtctatggg atgaagataa 1785661 caaacagttt gtgtcatttc gggctataaa acatatacct gtaagccttc cgcctgattc 1785721 accagaaaaa cagaagctgc ggaagaatgc ctgatgataa aggaggtctt ctaatatact 1785781 agaaggcttc ctttttattg ttggagggtg cattctggct ttcacaatga taaagttaca 1785841 agtaagatga aaagctgaaa atgaggtaag atcatgatta aaaatcattt tacatttcaa 1785901 aaactaaacg ggattacgcc ctatatatgg acgatatttt tcatcctccc cttctacttt 1785961 atatggaaat catcatctac atttgttatt attgtcggca tcattttgac gcttttattt 1786021 ttttcggtat atcgatttgc ttttgtctca aaaggctgga ccatttattt gtggggattt 1786081 ttattaattg gcatttcaac cgcctccatt actctgttca gttatattta ttttgctttc 1786141 tttattgctt attttattgg aaacattaag gaacgcgtcc cttttcatat tttatattat 1786201 gtccatttaa taagcgcggc cgtcgcagcc aatttcagtc tcgtattaaa aaaggaattc 1786261 tttctgacac aaattccttt tgtcgttatt accctcatca gcgcaatttt attgcccttc 1786321 agtataaaaa gccgcaagga gcgcgaacga cttgaagaaa agctcgagga tgcaaatgaa 1786381 cggattgcag aactggtaaa attagaagaa cgtcagcgaa ttgcccgcga tctccatgat 1786441 acgcttgggc aaaagctttc tcttattggt ttaaaaagcg acttagcaag aaaattgata 1786501 tacaaagatc ccgaacaagc agctcgtgaa ctgaaaagtg ttcagcaaac agcgcgaact 1786561 tctttaaatg aagtaagaaa aatcgtttcc tctatgaagg gcatccggct caaggatgaa 1786621 ttgatcaaca tcaaacaaat tctcgaagca gctgacatta tgtttatcta tgaagaagag 1786681 aaatggcccg agaatatctc attgctgaat gaaaacattt tgagcatgtg cttaaaggaa 1786741 gctgtcacaa atgtcgtcaa acacagccag gctaaaactt gccgagttga cattcagcag 1786801 ctctggaagg aagttgtgat tacagtgtct gacgatggaa cattcaaagg agaagaaaat 1786861 tccttttcaa aaggacatgg cttactcggg atgagagaac ggcttgagtt tgcaaacgga 1786921 agccttcaca tcgataccga aaacgggacc aagcttacca tggcaattcc taataattca 1786981 aaataaacat aaaggatggc ttatatgatt agtatattta ttgcagaaga tcagcaaatg 1787041 ctgctgggcg ctttaggatc acttctaaac ctcgaagacg atatggaagt cgtaggcaaa 1787101 ggtacaaccg gccaagatgc tgttgatttt gtcaaaaaac gccagcctga tgtatgtatt 1787161 atggacattg aaatgcccgg aaaaacaggg cttgaagctg ctgaggagct aaaagataca 1787221 ggctgcaaaa ttatcatctt aaccaccttc gccagacccg gttactttca gagagctatt 1787281 aaagctggcg ttaaaggcta tttgttaaaa gacagtccga gtgaagagct ggccaacgcc 1787341 atccgtagcg tcatgaacgg aaaacgcatc tatgcacctg aactgatgga ggacttatac 1787401 agcgaagcta accctcttac agatagagaa aaagaagtgc tcgaacttgt ggctgacggt 1787461 aaaaacacaa aagaaatcgc tcaggaactc agcatcaaaa gcgggacggt gcggaattat 1787521 atctcaatga ttctagaaaa gcttgaagtg aaaaatcgaa ttgaagccat tacccggtca 1787581 aaagaaaaag gctggtttaa ataaaaaagg atcttggcat ctgccaggat cctttttgtt 1787641 aacctgaaat tcccgtttga gaacctcgtc gcaaccagaa ttaaattgat ccatatcctc 1787701 gctcctacgc ccgctgaacg attgtttggt taacagccca ataaaagact ggattgaatg 1787761 atatccctgt taaaatggtc ggccattgca catcagcaga atttctgata ttgattatat 1787821 tgtattttca gtatgacaaa gttgtgccac ttcgctcccg aagctgccat gcccaactgc 1787881 aagagcctaa tatcacaata aaaaaccgtc tgaaatcaat ccgattccgt aaatggtatc 1787941 tgctacatcc aactgcttat tatctgccaa aaacaccagc tcgtttcgct gatcaaagat 1788001 agtaacaacc agctataaat gtcatgatgc cgaatgtctc tgtaatgtgg aatcaatctt 1788061 ttaacccgag agcccctgaa tcgcacataa agaaaaacgg gaccactttc ttttatcagc 1788121 atatgatata aacagctcta agcagaacaa aaaaagacac aagccaaaag cttatgtctt 1788181 ttatcacaat ctatattatt agtttaagac tttaacactt acagttttga cgccccaatt 1788241 agaagcatca cttttacttg gtacaaatac gtcgatttta tttcctttaa tagcgccgcc 1788301 agtgtctgct gctgttgctt ccccgtagcc ttcaacatag actttagaac ctagcggaat 1788361 tacattagga tcaaccgcaa taactttcgc gttcgggttc ttatttaagt caatgcctgt 1788421 agctgtaacg ccggaaatgc cgccgtcgtt agcagtgtaa gcagtagcag taactgttag 1788481 ttcttttgaa gcttcttgat tatttgtatt tgattgaaca gccttctcct ctgtgttaac 1788541 agaagtttct gcctcagcct ttgtttcttg tttaggttgc tgttgtacag cttcttgttt 1788601 aggttgctct ttttgcacag cctcttgttt tggcgcagct tgaggtgcgt ttgtttgcgc 1788661 attctcagta gctgtgtttg ctgctgttgc ctgacctttt actgaaagag ttgatccagc 1788721 atagatcatg tcagagctta agttattcca aactttcagg ttgttgactg tcgtgccgaa 1788781 tttttgagca atcttagaaa gcgtatctcc cgctttaatt gtatattgcc cagtcgtggt 1788841 tgtttcttct gaagaaatgg tcagtttttc tcctgcaatg attttatcag aagttaactt 1788901 gttccattct tttaagtcct ttaggttcac tccatttttc tgagagattc cccagagcgt 1788961 atcacccttt tgcaccgtaa tttcttttgc agaagcgtga gctccgaatg cagttgttga 1789021 aagtgcagca actgccacaa aggacataat cgtcttcttc ataagtaaat cctcccttgt 1789081 tagcttttta ttggcggcta acaggtgata tcgtaacaca cgtaaatgtc aaatcaataa 1789141 caaaaagata tgatttagat tacagttcct ttacatgaag gatttctctc tgatggaaag 1789201 acttgctgaa cccttgatat aataggcttc gcaggtcttt ttattttgag gcgaaacaga 1789261 gaaaataaaa tgtgtttttt atagaaaaaa agattgtttt tctgtttttt tagtctgtca 1789321 tccttgcata agcctgtatt tcttgtaaaa aaagccggcc gtattttgct cttttttgtt 1789381 ctccgactcc ttttatagac aaaagttcat catcatttac gggctgtttt cctgacattt 1789441 cttttaacgt ttggtcagag aaaacaacaa atggcggaac accctgctca gccgcaattt 1789501 ctttccgaac catgcgcaat cgttcaaata gctcgtcatt ttcagtaatc gctgccgctt 1789561 ttaacgcttc ttttctcgct actgataatt ctcctttcag cacattcctt cctttactgc 1789621 tgacaaaaag agtcggaaac gttccgtctg acatcctgat gaagtcgtca gaaataagaa 1789681 attcgataaa atcactgatt tcgccaacgg attggtgttt taatatcccg tatgttgaaa 1789741 ggtcggaaaa gccgttttca agaacttttt tatttttgga gccggcaagc acctgggcaa 1789801 ccatcgtctt gccaaaccgt tctttcatgc gaatgataca agataagacc atttgcgcct 1789861 cccgcgtcac gtcatgggcc gctcttgtat cggtacagtt tccgcactgt ccgcacgcat 1789921 caggctcctt ttctccgaaa tacataagga taaaacgctg cagacaatct tccgtatgac 1789981 agtagtcgac catttgtctc agctttttta aatcctgctt ttgtttctct tcatgttctg 1790041 attgctcaat taagaagcgc tgcaccataa tatcctgcgg tgaaaacagg agaacacatt 1790101 cactggcaag accgtcccgt ccagctcgtc ctgcctcttg ataatagctt tccatatctt 1790161 tcgggatttg tgcatgcaga acaaatctga tatttgattt atcaataccc attccaaaag 1790221 cagaggttgc caccatcact tgaagctcat cattaagaaa tctttcctgc tgctcttttc 1790281 tcacatcatc agccaaacct ccatgatacc ggcctgccct gacctgattt cgtttcaatc 1790341 tctcatatat ccgatcagct tcttttctgg tcgctgtata gacaattcct gcttcatgcc 1790401 tgttgttttg cacatattcg tctataaacc gatctttatt ttctcctttt actactttaa 1790461 aggttaaatt ctctcgggaa aatccggtat ataccgtgtt ttctttttga atatgcagct 1790521 gtttgcaaat atcatcatga acctcgggtg tggctgttgc tgttaacgcc atgatgacag 1790581 gcttgtcgtg taattcacgg aacaagattt caatattcct gtagcttggc ctgaaatcat 1790641 ggccccattg agaaatacaa tgcgcctcgt ctattgcgac caaaggaaca tctatgccct 1790701 gcaaaatccg gataaactct atggacgtta gtcgctctgg tgtaatgtaa aaaagcttat 1790761 aagccccttc tttgagtccg ttcagcctct catatatttc ctgattggat tgtgtgctgt 1790821 taatgtaggc ggcgttaatc cccgcttctt ctaacgcatc aacttgatcc ttcatcaagg 1790881 aaatcaacgg tgaaatgacg atcgtcgtcc cttcaaacat taatgccgga atctgatagc 1790941 aaatcgattt gccgcctccc gtcggcataa tgcaggccgt attttgcctc gcttccgtca 1791001 ccaagcggat cgcttcatct tggccgctcc gaaacttctc ataaccaaaa taatgagcca 1791061 gaagggattg ggctctatgt aacataacgt gtaaacctcg cttttccttg aatttctccc 1791121 atcatatcat aaaaaagcgg ccttcatttc tttcacacaa aaatggaata ttcactatac 1791181 caaacctttt tagataaaat aaaaagccat ttccgaaaag gaaatggctt tcgctacgtc 1791241 ttgccgtatg caagtaagaa agttttaaac caccactcct caaagtgggt gtttgcagaa 1791301 acgttcctgt cgtcctctgc aatggaggca tgacattccg gcttcgatat aaaactccct 1791361 attacagctt aaaggttaaa acttaattaa caatacgcac aaagtagctt ctttaatata 1791421 gtacaccatc aggcgctttt aatcaagagg tcagaacaat tgtttagaaa aactttttcc 1791481 agtgaataaa actgtttttt ctccaaaata cctgacaatt cgacaaacaa aaaatatatt 1791541 acaataaaaa aaatagcctt tattgctaaa agcgaatgat tattttcttc tatattaatg 1791601 tgtatataca aaaagactcc tatttgtaac gataggagtc ttggctttat tagaattttg 1791661 cagcaagatc ttttgcttct tgtaaacctt tttcaacgat ttcttgcgct tgatcaggtg 1791721 ctgcgttatg tccttcgatg acaactgtgt gcaagtcttg aacaccccag aaaccaagaa 1791781 ctgttttcat gaagtttaat gacatttcaa gtgcagccat tggtccttct gagtagacac 1791841 cgccgcgagc gttaagaagc gcaacttttt tgccgcccat taaaccgact ggtccttctt 1791901 gtgtgtattt gaatgtaacg cctgcgcgag acagataatc aacataagta tgaagcactg 1791961 ctggcactgt gaagttccaa agcgggaatg cgaaaacaac tttgtcagct tttacaaact 1792021 ggttcagata tttgtcagca attgctgctt gttttttctc atcttctgtc atttccattc 1792081 cttgacctgc tttaaatgtt ccgttaatca tatctctgcc aaggtaagga aggttttcct 1792141 tatgaagatc taattcaacc acttcatcat tagggttgtt ttctttataa gcagctaaga 1792201 aagcttcgta aagtttagtt gaaacgcctt cttcagctgt acggtcgctt gattttacaa 1792261 ataaaactgt agacatttgt attcctcccg gtaaactttt tatatttact tacaaatagt 1792321 atgttacttt cttttttacg taaagtcaat cactttattt tgaatatgag attttttttc 1792381 aaaaaaaagc aagtacatct aatatcggtg tacttgcttg gcatttttac ttcgaatctt 1792441 gttcacgatc caagatttca tacgtctgcg agcttttttg atcaattgtt tctttgttgg 1792501 ataagtcttt tacctgttca tgaaactctc tttcataaga aggagcatct gtctccagat 1792561 catcctccac atcagcttgg gcctcaactg tcattcttgc ataaggaaca gcttcaagtc 1792621 tttcgtaagg aatctcttgg ccggtttttt cacacacgcc ataagttccg tctttcatct 1792681 tttgtaatgc acggttgacc tcctctaaca gctcccggtc aatctctttc actgtttggt 1792741 ctgtcatccg gtctgtgacg agcgtcccgt ggtctgccat atggttgtca accccattgg 1792801 aaagctcccc cacttcttcc gtcattgatt ctgtttcctt tttctcgcca gacaattctt 1792861 tttgcatatc gagcaattta tgatagagat gctgtgtttg ttcttttgtc agtgccatgt 1792921 atatcctctc ctttctatcc tgtttcccgt tttgccttct gtcaaacatg gaaacatcga 1792981 tggaaagatg agctactgcc tttttgaacg gatcgtgacc gctggcgtcg atggtgcttc 1793041 gggttttcgt tggcactttt tgtccttctc ttctggcggt atataatagg ttgcgcctat 1793101 atttaatctg ccgctcagtt catcaatggt cagctcgccg aattcaagat gatagtcaac 1793161 tttttcgaca ttcagcgttt caatatgtat ataggtttct tcagactctt gtttgctgct 1793221 ttgtttttgt ttctcaatca ctgagagtct ttcttcacat tcacgcagtt tgtcaagttc 1793281 tggtttcaag caatgcctga tcagcgaccg gaacattttt ttcatgacat cacgaccctt 1793341 tgcatactcc tctttcgtct acatatataa tgaggtatat cccatagaaa ggagaggttt 1793401 tcatgcttcc gactaacatc aatatttctc atctcaagac taactcgata ggcaccggct 1793461 catcccttac ctttggttct gcggagttaa ggaacaggtg ctctgctatc aaaagaaata 1793521 acggttttgg ggaacaaaat gcagatggta ttgttatggt cattccgatt gaatcaattg 1793581 atgaccgtga tgtgtcagat gcactcagta tgaaaatcaa tcatcaataa caatggtttt 1793641 cgcttgacct tcgtcttttt gaatagtgat gtataggatt ccgtctttaa aaatggcatt 1793701 catctttcca tgaagatgat cggaaagcgg aattttcttt tcaaaacttc cgtatttccc 1793761 ttctttttgg cgaaagtcct gttcattaaa ataggaaaag cgctgcccct tcaccactaa 1793821 ataatctccg tacgataata tgtgaacgtc ttgtttacgg tagcctggaa gataaattaa 1793881 aaactgcact tccgcaacgg tatctacaat atccatgctc ggaaatgaag catctccttt 1793941 ccctcgctga tcttgctgcg caaacggaaa cggagattgg ccatttgtca taaaaggggt 1794001 tttttggtct tcatcaaata cctgtttcca aaagtcaccg ccgtacatct gctgtgcgaa 1794061 ttccatccac tgcttcatct tttcgaaatc catttgaagc cccctgtctt aacatacttt 1794121 ataaccgcca gcatacaact atagaaagga ggtttgcctg tggttcaacc aactccgtat 1794181 atcaatatta atattttcat gctgaaaatt aattcctttg aaaatgcttc agcggttaac 1794241 gtaggacaaa atttattggc agaatggcaa aattcagata aaaaaaatca aggctacgga 1794301 cagaattttg gagatgcgag cggatttatg ggcacgagaa gccatgtgga tgacagagac 1794361 caaattgatt ctccggcctc ttttgaaagt gaagcggtta actcctcaat caaaaggaag 1794421 tgatgagatg ttcttttcac cctccgtcgt aaatgtcggc ggatttaaaa tcaatacgat 1794481 ggatcgaggt tcctctttaa cactcggtcc gtatcagcag gtcgattact ttttatcagc 1794541 taaaataaat caagggtttg gagaagaaaa tggcgacttt actcctcttg tcgtgccgat 1794601 ttcaaatgta ttagatgcag atcttgttga ttcgaactca gcgaaaaaca gtgtggtgta 1794661 ataagaacag ggcgcacatg ccctgttctt gtttttatat ataaaaaaag cctaaccatt 1794721 ttttgaacgg ctggctcatc aaatattcag ctgcacaaat gctttgtcag caccgcctga 1794781 acctcgctta aatcggtgtc tttcgcaaat tctaattcga aagttttgct tcttgtcatc 1794841 aataaaagcc cagtgtccgg atcaaacatt cccgcttctt ggatggcaaa gctttcaatt 1794901 gttttatatg gaagaaatac acgaaccttc tttttagaaa acattttatt gtcaaagaaa 1794961 atgatccgct tatttgtaaa gcaaatttgg tccactcgga gcttataaat cgattcaatt 1795021 ctttcccctt caacgagcaa agcctcaagc ttctttgcgt ccgttgatct gctaacagaa 1795081 aaaataccca atgaagaacc cctctttctg catttatcta tttgttttat cattcactac 1795141 ataaaaataa gtcctttatc cctatataag aatacgacat agaagacatt taaaccatta 1795201 cgaacagatt acatttttca aatttttgat ttgttttttg gcttttaagc tgttgtcatc 1795261 aagtaatacg cacatataga gaaaaaagtt tcaatattca gcaatgtttt tataaaaaag 1795321 tggtttttaa tgattttttt aattttgttt tatatttcct gttttaacca caaaaaaacc 1795381 gcagctgagc tgcggtttta tgtatcgact gcttttaaca aaatctgttt gatgcttcaa 1795441 ggaagcatta catctcttcg aagtattctt tataatagcc gccgacttta ttcgtattgt 1795501 cgaccacaaa gagaaactcc tctgtttcat tttttacttc atattctttt cccggcgtta 1795561 aaacgcggtt tacgatatat ttttttgcgt ttgtctgcac acactttact tttttaatgg 1795621 tttctttttc aagccaattt ttatgaatca tgatgaaatc tccttttctt atctataagc 1795681 ttattgtagc ttttttcttt tgtaaattgc aatatcggtt attcattgat tttgccttga 1795741 tttctattat agaatgtttg tatacgctta cgtttgaagc aactatcaca gcttatttct 1795801 gctattcaat ccaggaatca atgtgctatc accaagaatc tcagaacaga ccataaaaaa 1795861 tgactggagg tttgttacgg atgagttctt taacgatgca agtgacgaaa aggctggaga 1795921 catttttaca gggaacaaag aagctttata ttgacggaaa gtttgttccg agtgcctcag 1795981 gggcaacctt tgacactcca aacccggcga ccggcgaaac cttgatgacg ctgtatgaag 1796041 cccaggctgc ggatgtggac aaagctgtta aagctgcccg gaaagccttt gaccaaggtg 1796101 aatggagaac aatgtctcca gcttcgagaa gcagactgat gtataagctg gcagacttaa 1796161 tggaagagca taaaactgag cttgctcagc ttgaaacact tgataatggg aaaccgatca 1796221 atgaaacgac taatggagat attccgctgg ctattgagca tatgcgctat tacgccggct 1796281 ggtgtacaaa aataacagga cagacgattc cggtttccgg cgcttatttt aattatacgc 1796341 gtcatgagcc tgtcggtgtc gtcggccaga tcattccatg gaatttcccg ctcctgatgg 1796401 cgatgtggaa aatgggcgcg gcacttgcaa caggctgtac aatcgtcctc aaaccggctg 1796461 aacaaacacc gctttcagct ctttatttgg cagaattaat tgaccaagcc ggtttccctg 1796521 ccggtgtaat caacatcatc ccaggattcg gtgaagatgc gggagaagcg ctgacgaacc 1796581 acgaagcggt tgataaaatt gcctttaccg gttccactga aatcggaaag aaaatcatgt 1796641 ccaccgcagc gaaaagcatt aagcgtgtga cattggagct gggcggaaaa tcgcctaata 1796701 ttcttctgcc ggatgcgaat ttaaaaaaag ccatcccggg cgctttaaac ggtgtgatgt 1796761 ttaaccaggg ccaagtctgc tgtgcgggct cacgtgtctt cattcataaa gaccaatatg 1796821 atgaagttgt tgatgaaatg gcatcctatg ctgagtcact ccgccaagga gcgggacttc 1796881 ataaagatac tcaaatcggg cctctcgtaa gcaaggaaca gcatgagcgc gttctttcct 1796941 atattcaaaa aggaaaagat gaaggagcaa aagcagtgac cggcggaagc tgtccttttg 1797001 aagcaggata ttttgtcgca ccgactgtgt ttgcgaatgt tgaagacgaa atgaccatcg 1797061 caaaagaaga aattttcgga cccgtgctga ctgcaattcc gtacgaaaca gtcgatgaag 1797121 ttattgaacg ggcaaaccat tcagaatatg ggcttgcagc cggactatgg acagagaacg 1797181 tcaagcaggc tcactatatc gcggaccgac ttcaagccgg aaccgtttgg gtcaactgct 1797241 ataatgtgtt tgacgcggcg tctccatttg gcggttataa acagtcagga ctcggacgag 1797301 aaatgggatc atatgccttg gataattaca cagaagtcaa aagtgtatgg gtaaaccttg 1797361 aagactaaca tgtatgttta aaaaactgct gcctgccagc agtttttttc tttctgtaat 1797421 ggcagtaaaa gacgctgaat atatatgctt ctgaaggagt tgagcgtgat gggcacactt 1797481 caggagaaag tgaggcgttt tcaaaagaaa accattaccg agttaagaga caggcaaaat 1797541 gctgatggtt catggacatt ttgctttgaa ggaccaatca tgacaaattc cttttttatt 1797601 ttgctcctta cctcactaga tgaaggcgaa aatgaaaaag aactgatatc atcccttgca 1797661 gccggcattc atgcaaaaca gcagccagac ggcacattta tcaactatcc cgatgaaacg 1797721 cgcggaaatc taacggctac cgtccaagga tatgtcggga tgctggcttc aggatgtttt 1797781 cacagaactg agccgcacat gaagaaagct gaacaattta tcatctcaca tggcggtttg 1797841 agacatgttc attttatgac aaaatggatg cttgccgcga acgggcttta tccttggcct 1797901 gctttgtatt taccattatc actcatggcg ctccccccaa cattgccgat tcatttctat 1797961 cagttcagct catatgcccg tattcatttt gctcctatgg ctgtaacact caatcagcga 1798021 tttgtcctta ttaaccgcaa tatttcatct cttcaccatc tcgatccgca catgacaaaa 1798081 aatcctttca cttggcttcg gtctgatgct ttcgaagaaa gagatctcac gtctattttg 1798141 ttacattgga aacgcgtttt tcatgcacca tttgcttttc agcagctggg cctacagaca 1798201 gctaaaacgt atatgctgga ccggattgaa aaagatggaa cattatacag ctatgcgagc 1798261 gcaaccatat atatggttta cagccttctg tcacttggtg tgtcacgcta ttctcctatt 1798321 atcaggaggg cgattaccgg cattaaatca ctggtgacta aatgcaacgg gattccttat 1798381 ctggaaaact ctacttcaac tgtttgggat acagctttaa taagctatgc ccttcaaaaa 1798441 aatggtgtga ccgaaacgga tggctctgtt acaaaagcag ccgacttttt gctagaacgc 1798501 cagcatacca aaatagcaga ttggtctgtc aaaaatccaa attcagttcc tggcggctgg 1798561 gggttttcaa acattaatac aaataaccct gactgtgacg acactacagc cgttttaaag 1798621 gcgattcccc gcaatcattc tcctgcagca tgggagcggg gggtatcttg gcttttatcg 1798681 atgcaaaaca atgacggcgg attttctgct ttcgaaaaaa atgtgaacca tccactgatc 1798741 cgccttctgc cgcttgaatc cgccgaggac gctgcagttg acccttcaac cgccgacctc 1798801 accggacgtg tactgcactt tttaggcgag aaagttggct tcacagaaaa acatcaacat 1798861 attcaacgcg cagtgaagtg gcttttcgaa catcaggaac aaaatgggtc ttggtacggc 1798921 agatggggtg tttgctacat ttacggcact tgggctgctc ttactggtat gcatgcatgc 1798981 ggggttgacc gaaagcatcc cggtatacaa aaggctctgc gttggctcaa atccatacaa 1799041 aatgatgacg gaagctgggg agaatcctgc aaaagcgccg aaatcaaaac atatgtaccg 1799101 cttcatagag gaaccattgt acaaacggcc tgggctttag acgctttgct cacatatgaa 1799161 aattccgaac atccgtctgt tgtgaaaggc atgcaatacc ttaccgacag cagttcgcat 1799221 agcgccgata gcctcgcgta tccagcaggg atcggattgc cgaagcaatt ttatattcgc 1799281 tatcacagtt atccatatgt attctctttg ctggctgtcg ggaagtattt agattctatt 1799341 gaaaaggaga cagcaaatga aacgtgaatc ttatcaagcg gagatgttca attggtgtga 1799401 agccctgaaa gatcagattc aaaagcgagg tcagcttgac cagtttgaag atcaaatcga 1799461 caagatgatt gaggctctgg aagatgacca aacaacagaa gaagattggt ataaacaggc 1799521 cgctgccctt tatcgggata ttacagaatc agatgataca agtgaaagac gcgcttatgt 1799581 ccctataggg aaacacgtgc tgccaaagct tccttacaaa tactccgcct tagaacctta 1799641 tatatcacgc gatattatga tccttcatca tacaaaacat catcaaagct atgtcgatgg 1799701 cctgaacaaa gcagaatcag agcttaaaaa agcgagagcg acaaagaatt atgacttaat 1799761 cactcattgg gaaagagagc ttgcgttcca tggagcaggc cattatttgc atagtatttt 1799821 ttggttttct atgcatccaa acggaaaacg gcgtcctaca ggggcattgt tccaaatgat 1799881 agacctttca tttggaagct attccgcttt taaagaacat tttacccagg cctctaaaaa 1799941 agtggaaggc gtcggctggg ccattctggt ctgggcacct cgatcaggac ggctggagat 1800001 tttaacggca gaaaaacacc agctctttag ccaatgggat gtgatccccc ttttaccgct 1800061 tgacgtatgg gagcatgcct actatttgca atacaaaaat gaccgggcca gctatgtcga 1800121 tcactggtgg aatgtcgtgg attggcgcga ggctgaaaaa cgttttgagc aggcaaaaga 1800181 agtcgtttgg aagctctatt aaaaaaagcc ccctttcctc gggggcttcg tgtgttaaaa 1800241 aatacctatc acatgcaaaa acacgatgat gatggcaaca ggagatagat atcgaatgag 1800301 cagcagccaa accgcaaacc actttcgttt gagattggaa ccgcttttca gctcgtcaaa 1800361 caaatcctgt ttcggtattt ttagcggaac aaaaatcgaa atcagtaacg cacctaacgg 1800421 cattaaaata ttgctcacaa gatagtcagc cgcatcaaaa atagacagat gaaatatagt 1800481 gacgtcactt aagacaccgt atgataatgc agacggcaca ccgacaataa aaatagcaat 1800541 accgcctaac caagcgaatc gttttctctt attgatatcg cctttcgaca gtactgcgac 1800601 caaaatttcc agcattgaaa aagcagatgt caatgcagca aataaaaata gaagtaaaaa 1800661 tgctaataaa aagataattc cgaacggcat ttgattaaac acagtcggca gaacgttaaa 1800721 taacagaacc gggccttggt ctggcttgag gccgaatgaa aatacagctg gaaaaatcgc 1800781 aattccggcc attacagcaa caagcatgtt cataacagtt acagatacag cggactgtac 1800841 cagattttcc tgtttctcta aataagcgct atacgttacc atgacagata caccgacact 1800901 taataagaaa aaggattgtc ccattgcata taaaatggta ttggcatcaa ttgcagttaa 1800961 atcaggcatg aggaaaaatt tgattccttc catcgcgcca tcaagtgtaa ccgaacgcac 1801021 cattaaaatg atgaataata gaaaaagcgc cggcattaat acttggcttg ctttttcaat 1801081 tccgctgctt accccttttg caacaactaa aattgttacc accataaaga gcagctggcc 1801141 tcctacagcc aaataaggat ttgaaatggt acttgcaaat atcgtatcaa aaccagatgt 1801201 ttgcgataaa ccgccagtga agccttttat aatataaatt aaaatccatc cgcctacgac 1801261 actgtagaaa gatagaagaa taaagcacgt caccatgcct aaataaccga tccaatgcca 1801321 cttcgttcct ggagcaagtg ttttatagga ctgaacggca tctttctgtg ttcttctgcc 1801381 tatgatgaat tcacctaaca ataaaggcag tccgattaaa accgtaaata aaataaaaat 1801441 aagtaaaaat gcgcctcctc cgctggttcc ggcaacatat gggaatttcc atatcgcacc 1801501 aagcccgata gctgatcctg ccgcggctaa aataaagccg agcttcgaag accattgatt 1801561 tgcttccttc accgtatcac tcctatttga tctaaccatt ataaaggttc attgtaagaa 1801621 tatcttccta tatagtcaag aacattttaa ttagtttaca tcatatatct atagacatct 1801681 gccaaaaact aatattgaat tattcagaaa attatttata ataagagaat gttatgaaat 1801741 ttgtaagaat ttctgctgaa gttcttgata agtgtgttag gagtgttttt atggacatca 1801801 ttagaaaaat aagccatttt gcaggacaaa cctttggcat atgggtcatt gtttttgcag 1801861 tgctgggatt ttctttccca tctttattta cgtggatcag ttcttatatt acgatttttc 1801921 tcggcattat catgtttggg atgggcctta cactgcaagc cgatgatttc aaagagctgg 1801981 tcagaaagcc ttggcaagtt attattggag taatagctca gtatacgatc atgccgctcg 1802041 ttgctttcgg cctcgcattt gggcttcatc ttccagctga aatcgcagtt ggtgttattc 1802101 ttgtcggctg ctgtcccggg ggaactgcat ctaatgttat gacattctta gcaaaaggaa 1802161 atactgccct ttctgttgcg gttacgacaa tttctacctt attggcacct gttgtaacac 1802221 cgttgttgat tatgctgttt gccaaagaat ggcttcctgt ctcgccgggg tctttgttta 1802281 tctcaatctt acaggcggtt ttatttccga tcattgcagg tctgattgtc aaaatgtttt 1802341 tcagaaaaca agtggcaaaa gccgtacatg cccttccgct tgtttctgtc attggcatcg 1802401 ttgcgattgt ctcagctgtc gtcagcggca atcgggaaaa tctgcttcaa tcggggttgc 1802461 tcattttttc agttgttatc ctgcataacg gtatcggtta tttactgggg tttctttgtg 1802521 caaagctttt aaaaatggat tacccgtctc aaaaagcgat tgcaatcgaa gtcggcatgc 1802581 aaaactccgg gcttggggct gcacttgcca cggctcattt ctcaccgcta tctgccgtac 1802641 caagcgcaat attcagtgtg tggcataacc tttcaggttc tatgcttgca acatattggt 1802701 caaaaaaagt gaaaaagaag caagctggat ccaaaagcag caatctatca ctttaaatat 1802761 gcatcaaaaa gggtacatca ctttatcgtg atgtaccctt ttttattatc cttctaataa 1802821 aagctgttca ggatcttcca gtaaattttt gattgtcacg aggaaaccaa ccgcttcttt 1802881 accgtctaca attcggtgat cataagataa agcgatatac atcatcggac ggttttcgaa 1802941 acgctcttca tcaatggcta cagggcgcag ctgaatctta tgcatgccca gtataccgac 1803001 ttgcgggctg tttaaaattg gagttgacat caatgaaccg aaagtccctc cgtttgtaat 1803061 cgtgaaggag cctccctgaa gctcgctaag ggttaattta ttgtttcttg cttttttcgc 1803121 aagctcgccg atctcttttt cgattcctgc aaatgtcagg cgatccgcat cccgtacaac 1803181 cggaacgaca agaccttcat cagcagcaac agcgattccg atatcgtaga attttttaac 1803241 gatcaactca tcgccttgaa tttctgcatt caacagcgga tattttttca atgcagccac 1803301 gaccgctttc gtgaagaaag acataaagcc gagcttcact tcattttgct caaaaaattg 1803361 atctttgcgg cgttttctga gattcatgac agccgtcatg tccacttcat taaatgtagt 1803421 cagcatcgct gatgtttgct gtacctctac aaggcgtttt gcaatcgttt gtctgcggcg 1803481 tgacattttt tgcacttcaa caggtttgtc aaagctttgc tgtgcttttt gagcctgagg 1803541 ctgctgcttt tgctgaggag ccggttttga tgccggtttt tcgtacgctt cgacatcctg 1803601 cttgcgcact cttccaagcg gatctccagt tggaacttga gacaggtcaa ttcctttttc 1803661 tctcgcaagc ttacgggccg acggagaagc gatcgttctt gattttgctt cagattgtgc 1803721 ttcctcgctc acctcttgtg cagctggttc agcctgtttc tcttctttta cgctttcctt 1803781 gctttctgtt ttctctgtag gagcaggggc agaactttca cccgcgcctt ctgaaatcgt 1803841 accgataatt tctccgacct ggacggtatc acccgaatct ttcaatacct cttgaagtac 1803901 acccgattct tctgctgtca attcaacatt cactttatcc gtttctagtt caagcagata 1803961 ttcaccctgt tctacatagt caccaggctg ctttaaccat tgggctattg ttccttctga 1804021 gattgattct gctaattcag gtaccttaat ttccgccatt ttttcatttc ccccttagtt 1804081 tttgcgagtc aagctatcag atacaatacg ttcctgttct tttttatgaa ctgtcggatc 1804141 tccctctgca gggctggatc gtcttcttcg tccaatatat tgaacgctta ctccctctgg 1804201 tgcaatctct gtcaaatacg ggctgatata accccaagcc cccatgttct gcggctcttc 1804261 ctgcacccaa acgatttctt tcaggttcgg aagttttgca aataattctt tgactccttt 1804321 tgccgggaat ggatacagct gttcgattct cgcaatgtga agccactctt taccgtcttc 1804381 taacttatta aaatgatcgc taatgtctat agacacttta ccgctggata atacaagtct 1804441 ggttactttt tcatagtcat gagaaagtcc cgactgttca taaacaggct ggaagcggct 1804501 ttcgctgagc tcctgcactt ccgacaccgt atttgggttg cgaagaaggc tcttcggcgt 1804561 cataatgacg agcggtctga tttcttcacg aagcagcatt ttagcctgtc ttcttaaaat 1804621 atggaaatac tgtgccgcgc ttgtcaggtt ggcaaccgtc cagttgtttt ccgctgcaag 1804681 ctgcaggaat cgctcaattc ttccgcttga gtgctcaggc ccctgtccct cgtaaccgtg 1804741 cgggagcagc atgactaatc cggatttttg gccccatttc gcgcgtccgg cagaaataaa 1804801 ttggtcaaaa tacacttgag cagcgttggc aaaatctccg tactgtgctt cccacaaaac 1804861 aagcgtttcc ggtgaatgca cgttatagcc gtattcaaaa ccgagaaccg atccttcaga 1804921 cagcgggctg ttatgaacag caaatgatgt gctgcagtca gataagtgat gaagcggcac 1804981 aaattctttg cccgtctcac tgtcatgaag cacaaggttt ctttgggcga acgttccgcg 1805041 ctcggaatcc tgtcctgtta aacgaatcgg tgttccgtct ttcaaaattg aagcaaacgc 1805101 gagtgattct gccaaagacc attccacttt tctgtcatca tcgaacgcct tggcgcgtct 1805161 ttctaaaatg cgctttagct tgccgaaaac attaaatgac tccggccagt tgatcaattc 1805221 gccattcagc ttgcggagca catcaaaatc aatcgaagtg tccacatctg ggaaaccgtt 1805281 tgatacaggc tctggaagtt caatttcaca agcagtgtgt tcctttttag acggaacttt 1805341 ctgatatgca tcctcaatgc gcttcgttac cgatttttcg atgttttgaa cgacttcctc 1805401 ggtaaccacg ccttctttta ccagcttttc agcgaaaatt tgtttgacgg tcggatgctt 1805461 tctgacagca tcatacagca ttggctgagt ggttgacggt tcatccattt cgttgtgtcc 1805521 atagcgtctg tacccgatca aatcaatcag aaaatccttg ttgaatgttt ttcggtattc 1805581 gaccgcaaac ttaacagctg aaagacaagc ttcaggatcg tccgcattca cgtgaacaat 1805641 cggaatttca taacccttgg ccaggtcgct ggcatatttt gtcgatctgg attcagcgct 1805701 ttctgttgtg aatccgatca tgttattggc gataatatga atcgcaccgc ctacttgata 1805761 cccttttaaa gagcttaaat tcaatgtttc agctacaatt ccttccccag ggaatgcagc 1805821 gtctccatgg attaaaatgg ccagcgattt tgtttcatct tgtaccgggt atccgctttg 1805881 tgttcgcgtt tcctgtgccg ctcttgtgct gccttcaaca atcggattga taaattccaa 1805941 gtggctcggg ttgttcgcta acgtaatgcg cgctgatttt gtttcagcgt cttgaagctc 1806001 ccgattcgcc cccaaatggt atttgacatc ccccgtccat ccgtagctga ttccaatgga 1806061 tccctcagac ggtacaagat ctttgttcgg cgcatgctgg aattcagaga agatgatttc 1806121 atacggtttg ccgagcacat gtgccaagac attcaggcgt cccctgtgcg ccatcccgat 1806181 gttgacactt gtcgtgcctg atttgacaga ttgtgcaata atgtcatcaa gcactggaac 1806241 aagagcgtcc agaccctcaa tggaaaagcg cttctgcccg acgaatgtgc ggtgcaaaaa 1806301 ctgctcaaag ccctctactt ctgtcaatct ttccagcaca gctgacagct tttcagctga 1806361 gttcttctgg aacagctcgc cagattcaat ctttcttgtc agccactcgc gctctttgaa 1806421 gtcatgcaca tggtcaaatt caaaagagat ggttctttta tacgtatttc gtaaatactg 1806481 aatggcttct aaaccgttcg aaatgttttt aggagcgtct ttgcagatga cagacgcagg 1806541 tattgctttt atttcctctt ctgttagccc gtaatcggat aatggaaaaa gttcgctctt 1806601 tttctcatcc tttctgagcg gattgacgga agcgttcaaa tggccatagg ttcggatatc 1806661 ttctgcaagt ctgactgcgg atgcgatctt ttgaatcaga tcggctgtaa cacgtccctt 1806721 ttcttttgtt cccgaggcct cttttatatc gcttggcgga gcaccgagct cgtcgaacat 1806781 ttccttcaaa tccgggtcaa tgctgttcgg atcctgggta tactgatcgt aaagctccag 1806841 cgcatagccg aggttcggac cgtaaaaatc ttcccaattc attcgttgtt tcatactatt 1806901 ttgaaacatt tgaatattac ccccaactta aataatcaag tgattgattc actatcttga 1806961 aataactttc gaacgctgtg tccaaaatta tgtaataaaa acgcttccaa cgatatttta 1807021 ccactgtttg caatttgatt ctaccttgat tgttcacaaa atagtaaaaa acctttataa 1807081 aaaacaaaaa atttaatcat tcgaaaaaac aaacgccaaa aagcatagga ttaagggcta 1807141 tcctatgctt ttatgaagca gttttttcag cagcggatac aaaacatccg gtagctgatc 1807201 aacatccggg acaaatatac tgaattttcc gtacatatcc tggatcgtct tcatttgcga 1807261 ttcttctatt tctgagttgg agagaaaaac atttatcact tctattcctc tttttcgggc 1807321 ttcgataacc gcctcacttg tatcaacgat cccattttgt tcgtagccaa atgcggccgg 1807381 ctctccatct gagaaaacaa ttaagaactt ttgcgcctcg ctgcgatgca gcattttttt 1807441 cgtcatctgc ctaattgcgt acccgtcacg gttatcttct tctggctcaa gctgcataat 1807501 ggccggtcca gaatcttgtc ttaatgatga ttggaaggga ataaccgtat tgaaatagtt 1807561 tggctggctt ttttcggttg catcatttgt gtcctcccaa aaaccgacaa tctgatgcgg 1807621 aaccgctacc gatttcaacg cttcgtgaaa cagcacgatt cctcgttttg tttcgtccat 1807681 tttgtcgaac atgctggcgg aacaatcgac cagcaatgta aaaactgcgt cgatttctga 1807741 agatggttct tgctttttgt agaacaggcg cggatttcgc tcagtgaagt aacgaagaag 1807801 cttattgttc agtctcccgg catgaaggtc tgttctcggc aatgtttttt tatgctccag 1807861 cgttttttga atcatttgtt tcaaacgctt ttgatacgat tcaatcgttt ttgcctgctg 1807921 tttataagaa agctcttctt cactggttgc cggctgcggt tctttataaa ttggaaatgc 1807981 atatttattt tctttgccgt cagccatacc cgctccgttc ggctggtctt tttgggactc 1808041 cagcgcttcc agcttggaat agtctttccg tttcgtttgt ctggctgatc cttgaacaga 1808101 gccaagggcc tgatctccat cgtcgccttc ccttgaagca tcttttccta aatctgattt 1808161 tgcgccgtgt tcaatatcaa attgaaggaa gcttttagac ggtgcttctg tttcccggtg 1808221 ccatgtcggc atttcttctt catggatatc ctcatcaccg tctgattgtt ttggaagcgt 1808281 gatgtcatca ctcagcttcg gcgctttttt ctcttcttca aataacggct gttctgcagc 1808341 ttttgcgtaa tcaagctcag gcaaaaagaa gtaggtgttc aacatgtctt tatcgagtac 1808401 ctcttcaagt ccgtccatga ggtcctcaac aattttcaga acctgccgtg tcgaatctgc 1808461 ttcatacaca cgcaagagct gctgctcaat aaacgggcgc atcagatcga tatcttcacg 1808521 catggatgga agggtctcga gcggcgattc cgctgtgagc ttgaaataga tcgcgcaaaa 1808581 gagcgcatcg gtaaaaatgc ttcgttccaa atttaaggtc agctgggttg agaaatgttt 1808641 tctgtacatg tcttttcgct tcgcaaatac atgtttcgta cccgggcgct cacgtttgat 1808701 gcattcttcg atcctaatgt cttcaagcag cataaagagc tgcttggcaa aacttttaaa 1808761 cgtaagatgg cgatggatat cattcaaaaa gttcgcaaac tcatgcagcg agctatatct 1808821 tgttccgact gaacgcaggt agacgtcgct tttcagaccc gcttccatgt cctcagctgc 1808881 cctgtctttc caaaagtggc tcatatagat tttcttttca aatggattgt aataggactg 1808941 aacgccatac tccacttcta ccgcttcact cttggtgagt gttttggcca aatcagtcag 1809001 catcataaat aaaaatgaat caatcgtgct gtcgttaaat ttgataaatt tcatcgcagc 1809061 cccctcattc aaacagagtt tctgcaatat ttcggacagc cgctttttcc cgatcatcat 1809121 caagcttttc tacaattccc cgctcaatgg cacgacgcgg cggaatataa gcagctaaat 1809181 cacatgtatc gattaaagct ctgatggatg ccgcttcttc agacacctgt ccgttattgg 1809241 cctgaacgat caagtcagag gaaagcgtga taaatctgtc aatcaatttc tcgtctttca 1809301 aggctgactg agacatgagc acttgtttca gcagctcgcc tttaatataa ggcacatcaa 1809361 tgatgacaaa acggtttttc aacgcttcat tcagaggaac agttccgaca tagccttcat 1809421 tgatggctgc aatgactccg aaaccgcttt tagcccgtat gacctcgcct gtaaacggat 1809481 ttgtcatcat ttttctgtaa tctaatacac cgtttagaat aggcagtgtt tccggcttcg 1809541 ccatattgat ttcatctata taaagaaaat ggccttcctt cattgccttt gtaacaggtc 1809601 ctgaaacaaa ctcgattgtt gcctggccag attgattttc aatcgtttta taaccgacca 1809661 atgcctcagc gtccaagtcg actgaacagt tgacgctgtg catcggttta tgaaaatagc 1809721 tggacaatgt ttctgccagc tttgtttttc ctgaacctgt aggccctttc agcaggacat 1809781 ttttccccat ggctaatgca ataatggcgt caaataaaat ggcttcatcc tccgcctcat 1809841 agcctgatgt tcctataagc gattgaaact ctggggaaat aggctgctct ttatatgata 1809901 aaagcttttg ttgtatatct tccggcaatg ttaagtgctg tagttgagtt gtcatagaca 1809961 gattcccttt cctattcata ttccattaac gagtatacta aaaaagcccc tgtatgctca 1810021 atacaaaagg gcctggatga tattactgct tctcgttatt tcccaaaagg gctccgcaga 1810081 caatacgcgc accggaattg ccgcttgggt ttgtcagata atcgtccgct tgttcatgaa 1810141 taataaatgc acttccgtcc tcgtcgagaa tatttagttt acttcctttt ttcagtgaag 1810201 tgtcaggcgc attcattatg acatctacct ttccatcagc accgacttca aggttcggca 1810261 gatctccggc atgatgcccc atcggattat taaagccgtg ttctttgttc agtggattaa 1810321 agggaccgcc cgctgattca aaatccggcc tgacacaaga acctttctca taaatatgaa 1810381 aaccgagaga agcacctgga cgcaggctgt ttgcggaaat atgaatatcg aggccttcat 1810441 catctgattc tttgatctct ataaaaccga ctgctttccc ttcacgattg accagctgga 1810501 catgatgacc aaacgctgac gtttcaacca cttttttttc cggcacccgg ttaggagggt 1810561 ctggaggttt tttttgtccg catccggcaa ctcccagtgc cgtcagcatc atcaacagca 1810621 agagacggtg catactgtct cccccttgtt ttttctaaca gtgtggtcaa tcattgtctg 1810681 gtataaacaa aaaagcctat aaaaggcttt ttgtcatact catttttaaa aataacttct 1810741 tgcgcccaag taccgctgtt tccaatacga attgctgaga ttggaaatgt cgacgcccga 1810801 tgagcttgca tgaataaaat caccgccgcc tagataaatc cccatgtgag acgggccgga 1810861 tttatatgtg gtaaagaaga caaagtctcc tactgacggc tggctgactt tctgcatgac 1810921 attccaatac cctgccgtac tcaatcttga tatagatgat acattattaa tgaggtaata 1810981 aatgaagccg ctgcaatcaa aaccggcagg cgtgtttccg ccccatcggt aaggcactcc 1811041 gacatatttt ttcgcttccg ttatcattct gtcaatcttc gaacctattt gaatgtttga 1811101 ccctgagtta tcttttggct ttgttggctt tgtcggattt gaaggattag attttgatgc 1811161 tcccgaaata gtcagaacct gcccgatttg caacacatcc gatgataaat tgtttttatc 1811221 acggatgctt tggacagtga ctccgagccg atttgcaatt ttccacagcg aatcgcctgc 1811281 ttttaccttg tacgtcgttg tttttgaggg attggagttt gacggctttt tggaaccgct 1811341 gtttccgttc ttaggtgaac tgcttccttt tattttgagc acctgtttag gataaagtgt 1811401 atctgatgtt aagccattta aggtttttaa ttcggctaca gtcatattta agctgtttgc 1811461 gattttccac agtgagtcac caagcttgac cgtatatgta ctttttgaag aacctgaaga 1811521 attggaaccg ctgtttttct ttgatccatt tgatccgctt gaactgcttg tccctttgat 1811581 cttaagcttt tgccccggac gaatcaggtc actgctcagg ctgtttaagc ttttaagctc 1811641 agaaacactc attttatgat ttttagcaat catccatagg gaatcaccat atgcaactgt 1811701 gtatgttgat gttttgcttg aattagatgg ggatgtcgtg ctttttttgc tgctttcagg 1811761 aaccttaaga ctttgtccga cataaagcac cgttgatttc aatttgtttt cggatttcag 1811821 agctgatatt gtcgtatcat actggcggga aagtttccaa agagagtcac cgctttttac 1811881 ttttatcgtt tttgcttccg cgggtgctgc ggccatcgac gacccaacaa ctgcagaaac 1811941 agccaagccg gctacaatct tctttttcat tcattcaacc tcctaaactg tttttttgca 1812001 aaaacagcta gtattttgtt tccaaaaatg gcacacaact gttttatcgt caatttttca 1812061 gcaagttaaa cccttttcaa acatttggcg cagcattttc agcatcgttc gacctttaaa 1812121 ccttcaaata aacatctaac attttacata agcacgatat gtttttcgaa agtctaagga 1812181 actatttaag cgagggtaaa aatgatggtt ttctattgat gaacgaagca gtttctcctc 1812241 ctttcttgtc tatttttcta atcaattctc tatcggcgtg tcaaatccct tcctctgcat 1812301 tcttatgaaa tggcaaaaag cctgttcttt cgataagaac aggcttttac actatgcatt 1812361 tgctgattga gttttttgtt ttacagcttc aagaatgctg tcggctgctt ttttagagcc 1812421 gcctgccgct ttcagtgatt gtccaatttc ttttgccttt tcagcatacg aacgattatt 1812481 cattacttct tgtatcgtct ctttcagtag gctttcagac aattcttcct ttttaattac 1812541 ttttcctgcg ccgacttttt ctacctgatc tgcgacaaca aattggtcgc ctcccatcgg 1812601 aatgacaacg agcggggttt caaaatacaa accttcactt gtgctgttca ttccgccgtg 1812661 ggtcacaaat aagctggctc ttttcaagat ctcaagctga gggacatacg ggcgtacaat 1812721 gaaattctcc ggaatgtcgt ttaactcact tgttttaata tgcttgccga tggaaagcac 1812781 aactttaccg tcaaagtcct tacacacttc aaggcattga ttaaaaaact gcttttgatt 1812841 attaaaaatg gttcccattg aaataaacag cacgttttca ttgtcaatct gatcaaatgg 1812901 gaaatcattg tttccggctc tttctgtaat ggaaggaccg acaaatacat atcgctcgcc 1812961 aaattgctca gccagtggct gaaatcccct tgatgtaaag acgattgtca agtcaccatc 1813021 agctaaaaaa acatcaaatg gcttcttgat ctctgcttga aaatcagcat ttaacgtttc 1813081 tgcaagctgc tggtatgatt cataatgagg cgaatcttca agtgatcctt tcatgtacgc 1813141 tcccatcatt tccttcgcaa attcctcatt catcgcaaag gttgtacaca atgaaaatct 1813201 tggcagcttc agcatgttgg caatgacttt acccgcgaga agatggtgat catatatgac 1813261 ataatcatac gattcatgtt tgacttcctc ataaatatga gtcgcgatat ccttacaggc 1813321 tttcaaaaaa gcgcagagca tttctgtgaa atctctttct tcatcgccgg ttgcgttttt 1813381 cccgaagtaa tctcctctga aatcatgata ctcacgaaac tctatatcaa gagctgtgat 1813441 tttttcttta tattccttca ctgcgtagta cgtaatgttt tctccccggg atttcagctc 1813501 cttcatcaca ccgatagagg gattaatatg cccttcaccg gggaaaccga tcattaatac 1813561 attagccatg cggcagcacc cttcctttga gaatttatgt aatattttat acggtactat 1813621 aaatgcataa acaggtaaag tatttcactt aattaatatt catcatatat aacttttcta 1813681 ccagtttata ttccctgtct tcaagacaaa aagcattcag cttgaagcga atgctttaat 1813741 aaagatgcga attcagtcat tttgtctcat gataggattc ttaatcaggc cctttttatt 1813801 atttttacgt tcttggtgaa attaacggat ataatacacc gtctttggca aacgacatct 1813861 tccctgtttc ctctgaaacc acgagcacca gtgcatccgt atagcccgac ataccaagag 1813921 ccgcccggtg ccgggttccc aaatggatat ccacttcctt cgtcgtcagc gggagcacat 1813981 tggctgctga cacgagtttg ttttccctca ctaataaagc gccgtcatga agagggtttc 1814041 cgggaaaaaa gatgctttca attaatgaag agctgatctc ggcgtgtagg gaggtgcctt 1814101 tttgaataaa acgttcaacc gggtctgctc tttcaatcac aattaaagct ccatgcttat 1814161 gttccgataa ggctttaatc gccttggcca gctcaataaa tgccggcgta aattcctcaa 1814221 tgtatgattg caaataaaag gaggatgcaa tcccctgcat gtcctgaaaa acgtgcccca 1814281 aatcatctaa ttcacaaagg agacactggt ctttttcgtg aagcgttttc aagattagag 1814341 atgcatcacc taatatttgc tctaagtaca cctgtatttt ccccttgaac gcattttctg 1814401 atatctgctc atagcgcata gccttcatct cctgtttaaa tttccaactt ttcacgaatg 1814461 cttatcttat tgatgcacat tctattggta aaggagggat gtaaagaatg gaaatcgaaa 1814521 gaatcattca gtatatttgc acctttttag gcgtgatttc gctttctttt atttatgccc 1814581 aaatgtttag aaaaacgaaa ccgacaaaaa aagaataggc ccggcgttca ttgcttttta 1814641 tacataaaat gttataattt ctctcgttat gaaaaagaaa cggagatcaa tgtatgaaag 1814701 aaactcaaaa cgcccgggaa aaaatcaaac agctcttgca cattttaata ccgatattca 1814761 ttacccaagc ggggctttct ctgatcactt ttctagatac tgtgatgtca gggaaagtca 1814821 gccccgctga tttagctggt gtcgccattg gctcaagcct ttggacccct gtttacacag 1814881 gacttgcagg tatattaatg gcggtcaccc cgattgtcgc tcagttatta ggtgcagaga 1814941 aaaaacagaa gattcccttt actgttttac aagctgtata cgtggccgcg cttcttagca 1815001 tcgccgtttt agtgattgga tatgctgcag ttgaccttat tcttggccga ttgaaccttg 1815061 atattcacgt gcatcagatt gctaaacact ttttaggctt tttatcactg ggaattttcc 1815121 ctttatttgt ttacaccgtg ttgagatcat tcatcgactc attaggaaaa acgagagtca 1815181 ccatgatgat tacactcagt tctcttccaa tcaattttgt attgaattat gtatttatct 1815241 tcgggaagtt cggaatgccg gcacttggag gtgtaggcgc gggactggca tccgcgttaa 1815301 cttactggtg tatatgcatc atcagttttt tcattattca taaaaacgca ccgttttctg 1815361 aatacgggat ttttcttacc atgtataagt tctcttggaa agcatgcaaa aatttgctca 1815421 aaatcgggct gcctattggg ttcgccgtgt tttttgaaac gagcattttc gcagctgtca 1815481 cgcttctcat gagccatttt catacagtga ccatcgcgtc ccaccaggca gccatgaatt 1815541 ttgcgtctct tttatatatg ctgccgctta gcgtgtccat ggctctaaca attgttgtcg 1815601 gatttgaagc gggtgcagcc cgttttaagg atgcacgctc atatagctta atcggcatca 1815661 tgatggcgat cggcttttct ttgttcactg ccgcctgtat ccttttattc agagagcaaa 1815721 ttgcgggcat gtacacttct gaccccgatg tgctccggct gacacagcac tttttaattt 1815781 atgcgctatt ttttcagctt tccgatgctg ttgccgcacc gatccaggga gcactcagag 1815841 ggtacaaaga tgtgaactat acgcttgcgg ccgcttttgt ctcttactgg gtcattggcc 1815901 ttccggtcgg ttatatggtc ggtacgttta caagcctcgg tgcattcggc tattggattg 1815961 gattaatagc gggactcgcc gccggagcag ttgggctgtt tttcaggctg gcaaaactgc 1816021 aaaaacgtta ttcgcaaaaa caacacattt aaaagaggtg atcaatcatg gcaaaaaaca 1816081 aaaaattatt cgagtatctt tcccagcatg cggaaaccat cagttcaaca tggtatgaaa 1816141 caatcgagga gactgatccc aattccattt atgcctcaac agaccctgtt gtcattcaca 1816201 atttaaagag ccagaatctt gcctttaact ataaaataaa ccgtattttt atagatgatg 1816261 aggacgtata cttgcctata ctgaaagaat gggcctttga agtcacacag gatcaagagc 1816321 atttaaaaac tcctatccac tatattattc gggagtttgt cagagtgaga gatttatatg 1816381 tttcttatgt gaaagaattt gtccatctca atcagaatac tgtgaaaagc gaagaagccg 1816441 aagacctgta tcacgccctt ataaaagcgt ttgatcttgt gattcatatt tttatagaag 1816501 aaatgtacaa aaacacaagc cttcagcttc aggcccaaaa agatatgatt actgaattga 1816561 gcgctccggt catcgtgctg tttcacagcg tcggactgct gcctttaatc ggagatattg 1816621 atacagtccg cgccaagctg attatggaaa acacactgca tcaatgtgcg aaaaaaaagg 1816681 tgacacaact gtatattgat ttgtcaggag tagctgtgat tgatacgatg gttgcccatc 1816741 agctgttcag tctgattgag gcgcttcgtt taatcggtgt ttcttcaact ttgtctggaa 1816801 tccgtccgga aatcgcgcaa acagcggttc agctaggttt gtctttcgaa ggtatttcct 1816861 tgagatccac tctcgcttca gctattgcat cggacttaaa attaaaaaag gtataaggct 1816921 taaggcctta tacctttttg attaatcatt ccattgatac gtccaatata tttcttcttc 1816981 aaaccatgtt gccataacag gttcattatt tttcaatttc tcttcaagct ctctgagcat 1817041 gccttctgtt tgtgtgcggt gagctcttaa cgcattcatt ttaatatcag ctacttcttt 1817101 gatatcaagt acgacatcag cttcgccgag aacctcttct ctgttgcggg taatggccat 1817161 gcagattgta cgcggacggt cttctttctt tttgcggtat aatgcacgga taaccgcttc 1817221 cccgcatgca tcatggtcag ggtgcacacc gtgtccggga taaaatgtga caattaaact 1817281 tggttttaca tcatctatga tctcttccat gatatcagct aaatactcat cgtcttcaaa 1817341 ttcgagcgtt ttgtcacgga gtccaagcat ccgaaggtca ttgatatcca tttctttgca 1817401 agcgttgatg agctcttgtt ttcttagcag cggcaacgtt tcccgattcg cgaaaaatgg 1817461 atcgcccata tttctgccca tttcacctaa agtggcgcag gcatacgtaa cgggaatgtc 1817521 tttttttctg tttaaggcaa tgaggcctgc cactccatat gattcatcat cagggtgagg 1817581 caggattact agtacatgtt ctttcattat tattcaccct tttctttaaa ctgtgaacgg 1817641 tttttcgctg atttgcagag aaatagccag tttaccgccc ggcaggtgtc ccgccattaa 1817701 taaacggttt tcttcatcta ccgtgtattc agtcaagcct tcagcataaa tccagccttc 1817761 ttctgttttc aagccaacgc ggtaaggccc gttgcctttg atttttgcct gatgataagt 1817821 gacttttgca ttgcgaatat acgcaacaac cgtcatgttc ttttcattta agtgcgctga 1817881 ataagaacct gtggtggttt ctaaatggat atatacaggg cggtccgcat atcgttctaa 1817941 agatgcttgc acatcttctt ttatgatcgc tttcatgatt gctcccctct ttcttctttt 1818001 aaatactctg cacgttctgt atgtaatttg accagctgat atttcacagc cggttcgagc 1818061 tgtgaattca caatgcgctg aatcgcggca aaatattttt ccagcatcgg ttttcggagt 1818121 cttggatgtg ttcgtttatc caagagctca agatcaatcg cctctgctac cgcttctgcg 1818181 tcatcatgtg cgagagatcg gttattccaa agtgaagcat aggctttcac tatctcttta 1818241 tcattgtcca tcgtcttgct cctttatgtc ttacatacat gaaatgatta tacataatat 1818301 atgcatcagc tgaaaagcca aaggcctcaa tggctttttg acgcccgttt ccacttcact 1818361 tgtgaaaacg taaacaagag cagcgcagcc catatacagc tgaatgtaaa agccttcgag 1818421 cttgaaaatg gctcatggta aacaaacagc ccgatcagca gggtaatggt cggcgcaata 1818481 tattgtaaga taccgacttg atacagtggc agccgtttcg ctccttccgc aaacaataag 1818541 agcggcaaag ccgtaaacac accggccaaa aagagaagca gccacgtccc tccgctttct 1818601 gcacccgctg gctgaacatg tccgctgaac agcaaatacc ccaatgcaat gggcataatc 1818661 atgaatgttt ccagcgttaa accgatggcg ctcggcaggc ttgttctttt tttgcttaac 1818721 ccgtacagcc caaagctgaa tgcgagcaga agcgcaacat aaggaatgga gccgtattgg 1818781 aacgccgaga tgatgacacc ggctgccgca atcgaaacgg ccactaattg caggcgattc 1818841 agtttttcct ttaaaaataa aatcccaagg agcactgata caagcggatt aatgtaatag 1818901 ccaagactag cctcaagcaa aaagccatgg ttgacagccc atatgtatac aaaccagttg 1818961 atcgaaatca ggatagaagc aagaaataaa gagaggatcc ctccgttctt tttcagagag 1819021 cgcaactcct gccatcctat tttccattgc cgcaagaaaa aaagtacgat acacataaaa 1819081 acaaaagacc atataatacg atgagccaaa atatcaagag ccggcagctg ttcgagaagc 1819141 ttccaataga gcggaaacag gccccacatg ataaatgaaa cggctgtgta aataacgcct 1819201 ttttttgttt ctgcatgttg cattgatatc cctgcctttc tttagagcat cttatattat 1819261 atcacgtgaa agatctggtg ggcatatact attttgtccg tgaagaaagg atgtgaagac 1819321 aatgtttgag tggaacaagt actttccttt ccacaatcaa ttttctaaag aagcattaaa 1819381 aaaagctgat ccgaaagaag ttgaaacgta tgtcaatcgt gtgatggaaa gtgtgttcgg 1819441 cagtgattat gcggctcaat ttcctttccg cgatcctctc ccccaaaaag aacatcccgc 1819501 caaacctgat gcaaaacctg atgtcaaacc tgatattgat atattcgaaa cagcagacca 1819561 tgtgtttgta aaggtgccaa tcagcgaaga atggctggaa caagtgagaa tcaaacacac 1819621 atctcacgaa ttatggttgg aaaacctccc aagagcagat catccgaaaa aagtaaacct 1819681 tccttgttta gtcaaacgca aaggaacaaa agccgtctat aaggatggcc ttctggaagt 1819741 catgtttcaa aagcagcaag actacaatat gtccgaggta gaaatcatcc gataaaaaac 1819801 ggcctgcaat cgatgcaggc cgttttttat taatagaagc cgggatatcc cccgtatggc 1819861 acgccggcac caaaaccgta cggtccgcct ccatatccat aagggccagg aggataggca 1819921 tagggacgag aatagttaaa cagcgcactc ccgagaaaac cgcctaataa accgccgact 1819981 agaggagcgc caaacaaaaa aggactacgc gccggatatc cggctggacc tgggattccg 1820041 cgtaaatacg aatgatgagg gtacatgatt ttttcctcct ttatgtctgc ctatacgtaa 1820101 agtattcagc aaggaagaaa aacgattggg ctacggactg tctatgattg ttacatcaca 1820161 agccctgcca ataacacaca gccgagccct gtaaccgaaa gaactgttgt aagcagcgtc 1820221 caggtttgaa atgtttcttt catgctcaag ccgaaaaatt cctttaccat ccaaaatcct 1820281 gcatcattta catgacacgc aatgacactg ccggctcctg ttgcaagcac cattaacgca 1820341 gggtttacac tgccagcctc cataagcgga gctgccattc ccgctgtggt aagcgcagcc 1820401 acggtagcag agcctagaca cagacgcaga accgcggcga tggtccatgc aacgaatagc 1820461 ggcgacatgt ttgtttgacg gaaaaaatca gcgacataat cgccgactcc gccgtcaatc 1820521 agcacctgtt taaacgctcc tccccctcct atgatgagca gcatcatcgc aatttgcgaa 1820581 attgattctg aaatagatct gccgatttcc tgcatagata ttttacgggc atatcccatc 1820641 gtatagagtg caagcaacag cgaaatgagc attgccgttc ccggagtgcc gataaattct 1820701 ataatgtctt ttccttttga atgttcactc aataataaag aaaaaattgt tgccattgcc 1820761 ataaagataa ccgggaataa agacgtgaca gcactgatcg caaagcccgg tgtttcatcc 1820821 agctgaaatt ctttccttgg tcctaacccc gataggtttc catgcttttg atacgcacca 1820881 ggaaaccgtt tcatcgcaaa tttattaaat aaaggcccgg caatcacagt tgtcggaaca 1820941 gcgatgatga ttccaaaaag cagcacctgg ccaatatggg caccatatgc aactgagata 1821001 gcagttggag caggatgcgg gggcaaaaat ccgtgagtaa catttaaggc ggcggccatc 1821061 gggattccca gatacagaaa aggcattttt aattctttag caatcgcgta aacaatcggt 1821121 atcaacagaa caagaccgac ttcaaaaaat agggcaatcc cgatgataaa agaggcaacc 1821181 acaaccgccg cctgtattcg tttcctcccg aatttgtcaa tcagcgtaat ggcgatccgg 1821241 tagccgcccc cagcatctga gacaagcctc ccaagcatcg cgccaagtcc aaacactaaa 1821301 gctaaatgcc ccagctgccc gccaattcca gtctcaattg aaagaacaat tttattgata 1821361 tccattccaa gtccgatggc tactaaaaat gaaacgacaa tcagtgagac aaaggtattt 1821421 aattttactt taataatgag aaataacaga atcagcactc cgacagctac aattaaaatc 1821481 ggcatggtac ccctccaaaa gtgttttata tgattctcgc gacaatgttt tggcgctttt 1821541 catgcctaga tgaacagaaa gcgctttcat taataactaa aaacgtcttg gttatatgat 1821601 tgttatcttt tgatcaacta atatgttcat actaatctcc taatcaatga ctgtcaatcg 1821661 tttttatgag cttgtctcga ttacctaccg cctaacccaa tgatttatta gttatatgtt 1821721 gattaacttt tggttatatg ttatgttttt taaagttgac tgccaatcat tatatctctc 1821781 cattgtctgg aagcaaatga gacaatatga gaacagacgg ataacaactt cataagagga 1821841 ggagtacaca tgccattatt gcgttttgat gtaattgagg gccgtgatga aaaatcgctg 1821901 caattgttat tagatactgc tcaccaagcg atggttgaag catttggtgt tccggaaaga 1821961 gaccgttatc aaattgtcca tcagcatccc gcaaacgagc ttataatcca ggatgcggga 1822021 ttagggtttc agagaaccaa ggatatggtc atcattagca tgacaagcaa agcaagaacc 1822081 gaaagccaaa aggaaaaatt gtatgctctg cttgctgaaa ggctagaaaa aaaatgcgaa 1822141 atttcccctg acgacctcat ggtatctatt actgagaatg gtgacgcaga ctggagtttc 1822201 ggtctcggtg aggcgcaatt tttgaatgga aaactataag atttcgtctc cccacaaaaa 1822261 aaagaagaga gagctccaaa gaagctctct cttttttcat aaatgcggaa gtcatcagta 1822321 tagaagcatc cagcaatacg aaaaacctgg atctcctttt atatccggtt taaatgccaa 1822381 ttggaagctg actgggtttt ggctgaaaat ataaaatttt gctgatttgc ataataagat 1822441 acatcataat ccccatttac aataggttgg atgttatagc ttattgatca tttcctattt 1822501 tatatatccc cttcatatgc acatgacatt tttgccaatc cggaaatatc agtctgacaa 1822561 atataaaaag tcatgtaaac gggtgtgaac cgtacttaca tgactcacca tggaaacaaa 1822621 ggctcttttt caggtgccgc tttccttatt tctcttcttc acacactgtg tcaccaggct 1822681 cgcaaaattg atcggcccat gcctgcattt cttgaaatac agcttgaagc gctgttcctt 1822741 tttcagtcag cgtgtagatg actttgaccg gcgtttcagg gagaacctgc cgttcgacaa 1822801 tctcgttttg ttcaagctcc ttcaagcgct ctgccaacat tttttggctg atcatcggta 1822861 ttgtttccgt tatctcttta aaccgtttcg gcccatccat tagcacatgg atgatcagac 1822921 cgttccatcg ttttcccagc aatgagaatg cggattccat tttagggcac atcgtatttc 1822981 ccataagtct tcatcccttc atctattgat tgacatgtat tcaatgatcc attacaataa 1823041 tctttcaagt tacatttagt aagcttctaa cttttctatt atcataccac gtttatccga 1823101 aggaggaaac actatgacga atactctgga tgttttaaaa gcacgtgcat ctgtaaagga 1823161 atatgataca aatgccccga tctctaagga ggagctgact gagctattag accttgccac 1823221 taaagcgcct tctgcttgga accttcagca ttggcatttt acagtattcc acagcgatga 1823281 atcaaaagcg gagcttcttc ctgtagcgta taatcaaaaa caaatcgttg agtcttctgc 1823341 tgttgttgcc attttaggcg atttaaaggc aaatgaaaac ggtgaagaag tttatgctga 1823401 attagcaagc caaggctata ttacggatga aatcaaacaa acattgctcg gccaaatcaa 1823461 cggtgcttac caaagcgagc aattcgcacg tgattccgct ttcttaaatg cttctttagc 1823521 tgctatgcag cttatgattg ccgcaaaagc aaaaggttat gacacttgcg caatcggcgg 1823581 atttaacaaa gagcagttcc aaaagcaatt tgatatcagt gagcgctatg ttccggttat 1823641 gcttatttca atcggcaaag cagtgaagcc tgcgcatcaa agcaaccgtc tgccgctttc 1823701 aaaagtatca acttggctgt aaggatatga aaaaccttag tccgaaatcc ggactaaggt 1823761 ttttttatac aatcgcctct ttgtaccatt cacgagcctg ttcagcttca tgctgagtca 1823821 gctgatggcc cccgtcctgc cagtaaacgg aggctgatgc cccgctgtca cgcaaatagc 1823881 ggtaaagctc ttctgattct tccttcgtgc aaagaggatc gtatttcccg gcaccgataa 1823941 aaacagggag ccccgccata tcaggcagct cgataccccg aatcggaacc attggatgat 1824001 gcagaatagc cccttttaac acatctttat aatgaaaaag caggcttgcc gcaatgtttg 1824061 cgccgtttga ataaccgact gcaatcactc ggccgcgatt aaactgatgc gtttctgcag 1824121 cctcgtcgat aaaatctttc aattctcttg tccgcaccac aagatccttt tcatcaaaaa 1824181 ctccttcact cagacgtttg aaaaatcgcg gcattccatt ttcaagcacc gatcctctga 1824241 caccaagcaa atgggcatca gggtctataa accgccccaa tgaaagcaga tcgtgttcat 1824301 taccacccgt gccatgcaac agcaaaagta cgttgtcaga tgttcctttc tcataaatat 1824361 gcttcattat aaattccccc ttttaaagtt caggtaaaat gtctgtaatt tgttgtctat 1824421 gtttctccag ccattcaggc agttttaagg aagtccctag ctcagcaaac gtttcatctg 1824481 tcataaagcc cggttcatct gtggcaattt caaataagat accgcctttc tccctaaaat 1824541 aaactgatgt aaagtattcc ctgtcgagaa tttctgacga aggcagatgg ttttcagcaa 1824601 taatcggcag ccatttcgcc tgttcctttt tcttagtccg aaacgctaca tggtgtaccg 1824661 taccatatcc tccgactcct cttttttcag gatgtaaatg gacatcaatg acaccgccga 1824721 ccgccgctga agatgccagt ctgacaatct ggtcttcttc ggccactttg gtgtatccaa 1824781 agctttccgt taacaattgt atggtcgcct gcgggtcgta ggaatatagc agcacacctt 1824841 tcattcccgt aattgcttca tttgttgtga tcccgtcagg cgtccactcg cttttgccgc 1824901 ttttcgcatc ctccatgatc gccagcggaa ggtcttctgt atcatcaaaa ataagacctt 1824961 tttcaccaaa caacgttttt tcctctaggc tcagcccgct tttctcaaga cgttccttcc 1825021 aaaaagacag ggagcctgag ggaactgaaa agtacacccg gcccgcttgg ccttttccta 1825081 ccgttccctg tccgcttcct tggaacggaa aaaaggtcat tattgtaccg ggatctccgt 1825141 tttgattccc aaagtaaaaa tgatacgttc cgggatcatc aaagtttact gtttttttaa 1825201 cgagcctgag cccaagcact tctgtataaa atcgcaagtt ttcttgcgga tctctggcga 1825261 atgctgtgac atggtgcaat ccttctgttt tcattttctc actcctattt atctcgattt 1825321 caagatattt attattttaa acctttattg aaaaggatgc aaaccatgtg ttttgattaa 1825381 ataattgaaa aaatcatttt tttctaataa ttatcttgtg atcttttctt acaactgcta 1825441 ttatagtgag cattatcatg tttcaggagg aaagtaaatg gttaaaaaag cacttattgt 1825501 tattctcatt cttttgccat tcgttcagct cgcgcttttg ccgcttgtga atcgaataga 1825561 accgattatg ttcggcctgc cgtttttcca cttttggctg ctgctgtgga ttattgttac 1825621 gccgttatgc tcgtttggca tttatcagat gcaaaaaaaa gatggaggac ttgaataatg 1825681 caagggaatc tgactgcact tctcattact gctattattg ttttaaccgt tgtctgtatc 1825741 ggctttctcg ccggaagaga caaatcctca cgtacttctg tggaagaatg gtctgtcggc 1825801 ggcagacgct tcggcggtct tctcgtctgg tttttagtag gcgctgacct ttatacggcc 1825861 tatactttct tagggttgac cagtactgct tttacaggcg gaagtgttgc atttttcgcc 1825921 attccttatt ctgtgttggc ctactttatc gcctacttct tcttgccaaa actttggaaa 1825981 gttgcgaaaa ttcataaatt aacaacactc gcggattatg cccgggaacg ttttaacagt 1826041 aagcttttgg caagcctcgt tgccatcgtt ggggtactca tgcttattcc gtacatatgc 1826101 cttcagctga gcggcattca agacacgctt caggttgccg gcactggcta tattaacgta 1826161 aaattcgttg tgatcatttc atttattctt gttgctcttt acacattctt cagcgggatt 1826221 aaagggccca catatacagc catcattaag gacattttag tatgggtcat tatgctgttt 1826281 atggtggtgt ccctccctct cattcatttt aacggctgga cgccaatgat tgacacgtta 1826341 gtgaaggaag cgccgcaaat gctgacgata ccgtcagaag ggccaaaagg cattccttgg 1826401 tttatcacag catctattgt ttccgctctg gcacttttta tgtgggcaca tgccgctaca 1826461 ggtgttttca cggcgaaaag cgctgatgca gtaagaaaaa acagcatgtt tttgccgctt 1826521 tataatatcg tgttaatttt ggttattttt cttggcttta tcgcctttct tgttctgccg 1826581 gaagatacaa atccaaggct ggcgctgctg catttgattc aaacatctta cggcggcgtg 1826641 gcacaaggct ttgcatatgc cactatcgct cttgcttcat taataccttg ttccattatg 1826701 gcaatcggcg catcgaattt attcgccaac aacctatacc gggatttgat tcatccgaat 1826761 gtgtcgcaaa gcaagctgac tcttgtcaca cgttcaatgg tgtttgttgt catcggtctt 1826821 gcgctgctgt ttggaatgct gttcccgact gccttagtga cacttcagct attaggtgta 1826881 tccggtatgg tgcaaatctt ccctgcgatt gctgtcagcc tgttctggaa aaaccaaacg 1826941 aaagaagcaa cggttatcgg attattagcc ggcctagcgg taacgtttat tgtgtatatc 1827001 actcaatccg cacatggcat ttatgaagga ttctggggat tggccgccaa catgatcgct 1827061 gtggtcatcc tgaatccgct gttcgttaaa aacgcgggat ccaatcctgt cattgaaggt 1827121 ttatttggca aaaaacaaga cgctaatcca aatcaaaagg gcgcataaaa aaaccatacg 1827181 cggcagccgc gtatggtttt ttttacattt cttttttcag tgtttcaatt gccttttcca 1827241 tttgcgtatc attatcagac agcttctttt gaagttctat cattaatttc gttgttgtat 1827301 cgccagtcag tatgcctgtt tcattcagct tctctttttt ctggaactgt ttgacgacag 1827361 atacaaaatc ctggtcatac atactgttaa cctttacctt gtaaccaagt gctttgagca 1827421 ttttctgagc cactttgacg tttgtgcctg tatcacctga tttgtacgtt ttatctgcgt 1827481 ccaaatacgg cagcttcgcg taatcaggca gctctgcttt cacttgaggc ttgatgcctt 1827541 ttttgtgaat ccattcgcca tcagcagtca gccatttggc aactgtcagt ttgacggtag 1827601 agccatcatc atattctttt gccgtttgta ctgtaccttt gccgaatgtc gtctcgccga 1827661 ttaacggtac gtttgacgat tcatgaaggg cagcggccat aatttcggct gcgcttgctg 1827721 taccgtcatt tactaaaacg acggtcggct tggtcacttt ccgttctttt tcggccttca 1827781 tgacttcttt tgaaccgttt ttgtattcaa cctgcatgat gtttttccct ttatcaatga 1827841 acaggttgct catcgtaatc gcctgttcca ttaagccgcc cgggttgcct ctcaagtcta 1827901 aaatatagcc tttggcgcct tttttctcta aactgtcaat cgcatctgtc agctctttag 1827961 ctgttgtttc agagaaagaa gtgatttgaa tttctccgat gttgttgtct ttcatctctg 1828021 aatagacagt ctctacagga atggtatcgc gcttaatgga aagatcgata ttccccactc 1828081 ccgctctgtt cagttcaagc ttcacctttg tgcccttttt gcctcggatt aaagcgacgg 1828141 cttcatttac attcatgcct tttacgcttt ttccatttac cttaatgatt tggtccctcg 1828201 gtttgatacc ggctttttca gcaggtgaac ctttaattgg ggatacaata aggatttctc 1828261 cgtctttctc ctctacttgg gctccgattc cttcaaaaga tgctgaaatc gtctcgtcga 1828321 atgatttcgc ttgctcttga tccatatatg tagaatacgg atcatccagt gattgaatca 1828381 ttcctttaat tgctccgtct actaatttgt catcatctgt tttttggtaa taatcacttt 1828441 tgatttgctc atacgcttta tttaatttgt cgaacttgct gtctcctgtg cttgctgatt 1828501 tttggcccag gatactggaa ttgcccgtaa taaataaagt aagcgccgaa gcgacaactg 1828561 cagtgatcag cacaataaaa aacagtttta attgccgttt caattaaaca ccaccttttt 1828621 cttcttacat tattatcatg gacgaattct tattcgtcaa ctcggagcag aaatgaaaga 1828681 gaaacgccct tcttttgctt ttcataaacc tatgtcttta tacgacatat gataaggaaa 1828741 aaggaggatt cgatattgag ccgatattta gaaatgctgt ccttattcgg tgtcgcaggg 1828801 gcgcacccag gcgggctggc tttttcaaaa gcggtcttgc aaaaggctgc accctctccg 1828861 gatcagccga ttcttgatgc cggatgcgga acagggcaaa cggcggctta tttaggacat 1828921 ttgctgtatc ctgtaacagt cgttgataaa gatcctatta tgcttgagaa agcgaaaaaa 1828981 agatttgcga atgaagggct tgccatccct gcatatcagg cggagctgga acatctcccg 1829041 ttttcttctg agtccttttc ctgcgtcctg tcagaatcgg tcctcagttt ttcacgcctg 1829101 acatcctctc ttcaagaaat ttcaagagtt ttaaaaccca gcgggatgct gattggtatc 1829161 gaagctgctt taaaaaaacc aatgccccct gcagaaaaga agcaaatgat ggatttttac 1829221 ggatttactt gcttacatga agaaagcgaa tggcataaac tcctaagatc ctatggcttt 1829281 caaaaaacag aagcgatgtc acttcttccg gaagacatgg aatttgaacc aaccacagaa 1829341 atggatttat cgcaaacgat tgatcccatc tattacgata cgcttcaaac acattatcag 1829401 ctcatgcagt tatatagtga gtacatgggt cattgtattt ttatcgcgta caagtaaaac 1829461 ggcgtatcgc cccctgtttt cgtccaacct ttttttccta tctatcatat gctgatagaa 1829521 agtcaggata ggaggggaac aatattggag agatattatc atctttgcaa aaaccatcaa 1829581 ggtaaagtcg tcagaattac agagagaggc gggagagttc acgtcggcag aattacccgt 1829641 gtaacaagag acagagtttt tatagctccg gtcggcggag ggccaagagg tttcggttac 1829701 ggatattggg gcggttattg gggatatgga gcggcttacg ggatttccct cggtttaatt 1829761 gcaggagtgg ctctggctgg tttattcttc tggtaagcat agaacaaatg ctagattcac 1829821 cagacacaat gaagcccgct tatctagtgt aagcgggctt ttcattttaa attttcttca 1829881 ctttttcaaa gtactcttca agcgttaaat cattatcttg gatgaccttt gcggcttttt 1829941 tgcctacata gcgcagatgc catggctcat attcatattt cgtgatatct tctttatttt 1830001 tcggatagcg aataataaag ccatatttat aagcattgtc ctgcacccat ttcccgtctg 1830061 ccgtgcttcc gaacgcttca tttagctcaa agccattgct ccggctcgaa atgtccatcg 1830121 caaggcctgt ttgatgctcg ctttcacccg ggtaagcgac cgcttccttt gccttccttt 1830181 ccccttttag gcttacttca ttgtcaaaaa tgactttctg tctgtcatac gaacggtacc 1830241 ctgagacagc tgccagttca tagccttcct ttttggcagc atcgaacatt gtttttaatg 1830301 cgtcggccgc ttcttttctg atgtaacgtt tttgaatctt ttcttcaaaa gaaaactcta 1830361 catcaggtat gacaagatcg ctaggttcat agtttccggg cagtgcatat tgtttattga 1830421 caagcgcgag tatattttct ggattttgaa tggtttccag accatcgact tttttaatat 1830481 cattgaaata ctggctttcc aatgaaaact cactgttttg agtgtttgat tttttgctgt 1830541 cagctgtttt ttgttctgtt tgctttgttt ctgctgtggt tttcgtatcc ttttgagcat 1830601 ctccgttcga catgctgcag ccggctccga ctattgccgt tacactcaga gcggcagcca 1830661 gtgagaacca tttaccggac tttttcatat tacattacct tccttttatc aatcgtttcc 1830721 gcatgcataa agaagaggct gccggcaccc agcacgcctc ttgatatatt ttattgtgat 1830781 acggaatgta aagccacttc tatcatatca tgaaatgtcg tttgacgctc ttccgctgtc 1830841 gtttcttctc ctgttaatac gtgatcactc acggtgagaa ttgacagggc ttttcttccg 1830901 tgcttcgctg ctaatgtata caatgcagtt gtttccattt caacgccaag cacaccgtat 1830961 tttgcaagtt tttcaatttg cgaatcgtca ttgtagaact ggtcagctgt aaatacgctt 1831021 cctacagtca ccggcacacc tttatccttt gcggcatcat aggcattttt taaaagctcg 1831081 aaatctgcgc aaggcgcaaa atcaacgctt ccgaaagcaa ctctgttcat ttgtgaatca 1831141 gttgaggagg tcatcgccaa aatgacgtct cgcactttga catctttacg aatagcgccg 1831201 caggaaccga ctcttattag attttgcaca tcgtagcttt gaattaattc attcacataa 1831261 attgaaatag acggaactcc cattcccgtg ccttgtactg agattttttt acctttatat 1831321 gtacccgtaa atccatacat gcctctgact tcattgtagc attctacatt ttcaagatac 1831381 gtttctgcaa taaattttgc tctgagagga tctcccggca aaagcacagt atccgcaatt 1831441 tgtccttttt cagcacctat atgtacactc atctcatatc ctcctgtaaa tctaaattat 1831501 catccagccc gtccatttta caacgaatgt catgatgaaa caaacttcag cattgattat 1831561 aaaggaatat atcgaaaaaa gaaatgttcg aggatctgtt aggcacttcc tcagaaaaac 1831621 ggataatcgg ggtgttaatt tgaaaaccta accgcaggaa ggaggggtgg gacatgggta 1831681 aaaaacatcg taaccggatc accggccaaa aaaagaacaa tcatatacct gaaaaagata 1831741 tcattgcagc tgaagaagca cacgggaaag aatattccgc tgccaaacgc aagccttaaa 1831801 actgcagaaa actgcgggtt tccgcagttt tcttttcatt atgtcgtttg tacaatcaga 1831861 cgattgattt tcctccagcc ggcgggaagc agttgataat atgttttccc ttttctgcct 1831921 tcatcaatca ggatcacgtc ccctgtggcc atgaatcttg catcataatc actcggaaca 1831981 gtgtcgaata cattaaacaa agagaatgct cttttcagca cgtcttgatg atcgctcccg 1832041 ttcagttcag ttcgatagac ggctctgtag cccttttttt cgccaaaccg gggtgtctga 1832101 aatattgtca cgtcatagga acaagacttc tttttaaaca cggataacat catcaagatc 1832161 ccctcccttt tatttcttta acatattggc gtttttgctg tgttttcctc tctctatttt 1832221 tgtcgaaacc gcttaatctt ttcgtcaaaa ccttttacta ggaaaaacag aagcaagccg 1832281 aggctaaagc ctcctaacac gtctgtcaca aaatgaaccc ccagatacac tctgcttatg 1832341 ccgactaaaa cagcaattac accggctatg atatatacca tttttttatg cttagacaaa 1832401 aacgggagat gtttcactaa aaagtaagca ataacaggat agacacaagc agcattcatg 1832461 gaatggccgc tcggaaaact gaaggatgat tcatgaacca gcggtgcaaa atcaggcctc 1832521 actctttcga tccattcttt taagactttg tttaacagcc gatctgtgcc gaatactaag 1832581 agcatcaaca ggccgtccca tgtttttctg tagaaaaaca tgcctgctcc aatgatgaca 1832641 attagaggga gcagaaaaga agaagcacca agatgcgtga tccccgtcat gacttcatta 1832701 agccatggct gacggatcaa aacagctgcc ttgcttattg cttcatctgc agattgaaca 1832761 gcatttgtat gaatggccgc agctagaatt aaaaagaaaa gaaacaaact aacgggcttg 1832821 tacaatttta accacctcaa ttttcacaga agtcatagaa catgaataat aaaaccggag 1832881 ctgaccgctc cggttttaag cctcactcat cttcatccag ctcttcatct atcatacatt 1832941 tttctatcaa ataatcaaag gtaatatcag cgatttcaaa cagctcatcc tcactcggta 1833001 tgtagccccg tcttgcaagc tctctgtaaa aaaattcagc gatttcttcc gtatcaatca 1833061 caagatctat ttctttcatc tccgtaccgc ctcctttttt atgttttatg aaaaaacagg 1833121 ctgaattata cccggtgttc taaacaattc tttcagtcat atattgaata aaaaacgagc 1833181 catgggaggc tgacgctatg attgctaaaa tgatggaagc actggacgga gaaagatttg 1833241 atatcataat ggaaaaaacg ctcaaaggaa tgacgcgtgt gatgatttgg ggctgtctgc 1833301 catatttttt atatgtcttg atccgtatgt tcacaaatta actgaaatgc tcttttaaac 1833361 tttccaaaac aaacatcatc atgtctttat attcttcatc ctgaaacatt tcgtacagaa 1833421 ttttgtagtc attataaata tccagaagct catcaacaat tgacacagca aggatgtgaa 1833481 gggtatcttg atcttcatca ccgccttcaa actgaagaag agcagacgat gcgatatctt 1833541 cgccgatctc atggccagtt tctccgacat aatggacaaa caacagctga tgcacaaact 1833601 ggtccatttc atattttcta agcaccagcg tgagatcctc ttcctccgtt tcaagccact 1833661 ctccatcctt taaacgggtc agctcataaa tgatatcttc ccagccatct tctaaatatc 1833721 tccaaatttc tgttctatgg ccgataatgc gaaagagttc ttttccataa tctttaacat 1833781 aaacaacgtc cccaataagg aattcatact caatatcaag cttctccatg tcgacaatga 1833841 caccctcata atctttataa agctgaatag atgattcaaa gtataaaact tcgttatgat 1833901 tgacttcata aagatagtgt ttatcaattt ggtgtacttt tgtgatggtg ccgactgttc 1833961 catacataat gacgactacg atatccccta cttggaattt cggtttattt tgcttcatgg 1834021 tgtctccccc tcgccgcaac atttctcata cgctatcgta tgccgggtga agccaattcg 1834081 catgggcatg aaaaccaaag gaaatatcca attatggtat gggtatggac ataaaaaaat 1834141 ccgcagtgat ctgcggatga aacagctatt atctgccgtg cacttcagac tcgtattgat 1834201 cccaagcttc atcaaacgtc gccatcgtgt gaaggtaatc agcattcagc tccaaatatg 1834261 aactgatttc atgataatcg gttgatgttt ttggaaagct gtgatcctca tacgcctgat 1834321 tggcaaattc actgatgctg tccttcggct tagggtgtct gtatttcaat aaatagtgat 1834381 aaaaggattt catgggtttc ccctcctgat gtctgtcttt tgttgttcta ttatacagtt 1834441 caagtgtaaa attacaacaa aagaatactg aaacatgact caggagaagt caaaatagtt 1834501 gcgtttcaaa attctttctg tctccatgag ctgctgatat gtcaggcttt caggcagttt 1834561 ttttgtttga attaaaagca gctgatcctc aatctcttta accgtgtttt cctcttgata 1834621 ggtcataccg caggaagaac ataccatggc aggggtgtct gtcagttcta tagccctcgt 1834681 tccatcaggg agctcccagt acaccgtgtt cctgccgggc accgcttcga gctcgccgca 1834741 ccattcgcat gttttcatga agaatcccct ccgcattcag tctctttctg ttttttctgc 1834801 tgcgccaaaa atttcttttc tttgagctga tctcttttct cacgccgatc ttttaatgtt 1834861 tcatgctccg gatttgcgat gtatgcctct ctccttttga ttctgtctac attttcaggt 1834921 gtaaacgaaa cttctttgtc agcaaaaatg gcactcagcc cgatcggctc ctttttgtca 1834981 gcggtttcag ggaaaacgga ctcaaaatag gcgtctgcct gattggggat ataattctct 1835041 ggttccggat atgacgtaat cacaccttca aaatttctta agatcacttt gtcaggactt 1835101 tgtgacagga catagtttgg ctgcagggcg attttacctc ctccgcctgg tgcgtcaacg 1835161 acaaaggtag gaaccgcata gcctgaggta tgacctctca gcccttcaat gatctccaaa 1835221 cctttggaaa caggagctct gaaatgccct attccttctg acagatcaca ttggtaaata 1835281 taataaggac ggactctgat ttttaccaag tcatgcatga gctttttcat aattggaacc 1835341 gaatcattaa tacctgctaa tacgacagcc tgatttccga ccggcactcc cgcgttcacc 1835401 agcttttcac atgcctcaac ggattcttct gtcatttcga tgcttgtgtt aaaatgggtg 1835461 ttcagccaga ccggatgata ttttttcaat atctcgcaca gatgatcggt aatgcgctgc 1835521 ggaaagacga cgggagctct tgttccgatt ctgatgactt ccagatgcgg aatgctgcgc 1835581 agctctttta aaatatattc taaaatttgg tcgttgatga gcagcccatc accgcctgaa 1835641 attaaacaat cgcggatttc gggtgtttcc cggatataag caattgcagc atcaagctgt 1835701 tttttgggga cgcccattcc gatttgtccg gaaaagcgcc ttcttgtgca gtagcggcag 1835761 tacatggaac attgattcgt gacaagaaac agcacacggt cgggatagcg gtgtgtcaga 1835821 ccgggtaccg gtgaatcttc atcctcatga agcgggtctt ccagatcgta ttttgttttg 1835881 tgcatttctt cagaaagcgg cacagactgc atgcgtaccg ggcatctcgg attgtcgggg 1835941 tccattaaag aagcatagta aggtgtaata tttaagggga tcgttttggt agaaattctg 1836001 acgccttcct cttcatcctc ggtcagatta atgactttct ttaaatcatc taacgttctt 1836061 acagtgtgtg tcagctgcca aagccaatcg ttccatttct cttccggaac gtccttccat 1836121 aactcgatct ccttccaatg ccgtttcggt ttataccatt tgtttttcaa acgaactcct 1836181 cctcgcgcat attttgactt acagttgctt gcaccaaata ttcatgtttt caaggccttc 1836241 ggctataaag caattattga tcagccttcc gccatactga taacctgaat ggtacaacac 1836301 agcattcatc ccaaaagacg aagcacgggc gagagaaaac acatgaacga tatcctctcc 1836361 agccatttct ttttctaacg cctcgattaa aaagcttgtt aacgaatggc cgcgatattc 1836421 cggcagcaca gcgcaatcgg ttatttctgc atgcccaagc tctggattga tttctgcgct 1836481 tgctgcgctg atcaggcggt catgatcaag catgatataa tacaccgtat ttgcattcat 1836541 cgtcttttca atataagcgg ggtcaaatac cggggttggg tacgtgcgga atactttttt 1836601 atacagcatc gatagctggt acatgtcgtt tgtttctgct tttctcatcg taaaaacggg 1836661 tgtactgtcg ttgcgaagac ggggcgctgt gcgatatatg gcttcgatga tctcctgttc 1836721 ctctgtataa gaatctgttt gtctccggct ttctgaaagg taacgtacca tgacacaagc 1836781 cgaatggccg agataatagc cctttagata gccctccggc gcaaataatt gtttggcaag 1836841 gatcggctca tcatgctgct tcgcatagac aatgattttt tctgcattct cttcttttgc 1836901 cgctgccacg atatccggca gggccttctc aatggctccg tcataacgaa ccactctgat 1836961 tcgtttatta aagccgtcat ggtccaaaac tgctgtgaca ccgctactct ttattgactt 1837021 gagcatccgc atcctcccca tctgtatgaa ggccgcacca atccatgaca aaaagtgcaa 1837081 taattttagc agattctatc atggcttcaa cctcaatgta ttcattggcc tgatgagccg 1837141 tttttgtttc ccccggcccg aaaacgatca ctggtgtatc tcctgcatgg tacaaaagcc 1837201 ctccatccgt tccccacggg gaagcctcaa taatcggctc tgtctgtttc attttttgat 1837261 aggctgattg cagcacagaa attaaagggt gatcatcagg taaatcattc ggcagccatt 1837321 gagcgccaaa ccattcgact tgtacgggat ggcgtttaaa ccattcgtca tggtattcta 1837381 aatccttcag ccagttttcc aattcaagtt ttacagcttc tggtttctca tggggagcaa 1837441 ttccgcatct cccttctatg acgacacggt ctgcaactga agatggccag gcaccgcctg 1837501 agatggtgcc gatattcacc ggtaccggta ttgggatatt gtcatacagc ggatctgaaa 1837561 ttctcgcatt gcggactttc tccagctctt gtatcgctgt gataacgtgc atgctttttt 1837621 caatcgcgct taccccttca tagcgtgtgc ccccatgtgc ggataatccc ttcacagtga 1837681 tccgaaacca catcgaaccc tgctgcttaa taaatagttt catattcgtc ggttcaggaa 1837741 tcagcgcccc gtcagcacga tagcctctca tgatggcgga aagtgtaccg gcgccgccgc 1837801 actcttcatc tacaacactc tgaaacaata catctccctt cagtttgaca tcgcaggcgt 1837861 gcagggcttc taaagcaaaa agaagggctg tattgcctcc cttcatatcc gttgagccgc 1837921 ggccgtatat tttaccgttt tcttcgacag cttgatacgg ttcatacttc caatccttta 1837981 cgcttccttc aggcacaaca tcgatatggc cgttcaaaat cagggacctg cctccgccgg 1838041 ctcccgtttt tttagccacg atattcgggc tctcatgaaa atcggatcgg ttagatttaa 1838101 agtagggatg ctgttttaat tgctttatgc ttggctccca tacatcaatg tccatatgaa 1838161 attgccgcag cttttcaagc acaacagctt gggcgttaaa ctctgacccc aatgtgcttt 1838221 tttccccaat cagccttttg agaagacgaa tggctttggc cgaatgctga tcaagccact 1838281 cgattacttt tctttcaatg tcttgcatcc tcattccccc tcttaagaaa aaggcatatc 1838341 tattttgatt tcagcttctg tcagcctcgt cacctcatcg attgtcgagc cattcatcag 1838401 ctcttttaaa atgaagtgat ggctatcgac ctcaagaacc gctttttcgg taataatcaa 1838461 atctacacag cctgcagcag ttaatggcag cgtacatctt tctgttaatt taggccttcc 1838521 cttttgatct gtatgactca tgacgacaac cacttttttc gctttttggg caagctccat 1838581 cgccccgccc ataccaggca ccttttttcc cggaacaagc caatttgcca aatctcctga 1838641 ttggctcacc tgcagggcgc ctaaaatcgt aatgtcaatt ttgccttttc tgatcatcgc 1838701 aaaagacatg gttgtatcaa aataagaagc cccttttaca gcgcggacag gatatcccgc 1838761 ggcgttgcat aaatgcgcat cctcttctcc cttttcggga ctttctccaa tgccaaggac 1838821 accgttttcc gcttgaaaca tgacctgcat gtcaggcttc aaaaagttcg gtaccaagga 1838881 agggataccg ataccgagat tcacaatcat gccctgctta atttcagtag cagcgcgttt 1838941 tgcaatctgt tctctttctg ctactcccaa gcccatttcc acttcactcc ctcgcttcgt 1839001 acaaccccct caacaaaaac ccccggtgtg acaatcattt cttcagaaat ctcccccatc 1839061 ggaacgatac gctcagcttc ggcaaaggtt ctcctggcgg ccattgccat aagcgggttc 1839121 atattgcgcg cggttttgtc atacgttaga ttgccgaatt catctgcaat gtaagcattg 1839181 atgaaagcaa aatcagcagt cagcgcctct tcaatcaagt atcgttttcc cgccactgtt 1839241 acgatgtcct ttttttcgca aaccatttga ttatcaatgc ccacgtcggt taaaataccg 1839301 ccaagccccg ctccgccggc gcgaatccgt tccgcaagcg ttccctgagg tgaaaattga 1839361 acctctaacg tcccctctgt catctgtttt ccggctactg gattggaacc gatatgcgag 1839421 gcgatcaggg ttttgacccg ttgattaaca ataagcgggc cgattccgat atccgggaaa 1839481 ccggcgtcat tgcaaatcac agtcaaatcc gttacaccgc tgtccaatat cgcttcaatc 1839541 aatgaaggag gcgacccgac tcccccaaaa ccgccaaaca tcagaaccga tccatcccga 1839601 acatctgcaa ttgctgtgtc aatgctgatt gctttttgaa atggcgccat ttaatgtcaa 1839661 tcctttttta agtttttttc gaccgctgca actgtttctg aaaaaataga gataagctct 1839721 tccatttcac cgtctgaaat agtaaaagga ggagcaataa tgacagcatc tccttctcca 1839781 ctgtctattc cagctttgga aggataaaca atcagcccgc gttttttcgc ctcgctgaca 1839841 ataagctggg ttatcgcctg ctctggcgga aacactttct tcgttttttg gtctgccaca 1839901 aattcaatgc ctaatagcag tccttttccg cgcacctcac ctataatgcc gctttgagat 1839961 gccgcctcat caagcttctt cttcagcaca gcgccctttt tttctgattg tttgatcaag 1840021 ccgtgcttta acacatatcg caaaacttca agagcagctt tggctgaata gggatgtgca 1840081 ctatatgtgt gaccgctcat aatcacacct gacccttgtt ttatggtttc aataatagaa 1840141 tcagatacga cggcagcagc aataggtgca taccccgcac cgagtccctt ccccagtaca 1840201 gcaatatcag gtacggtatc ccaatgctct gtcgcgagca tccttcctgt tctcccaagc 1840261 cccgtcatca cttcatctgc aataaaaagc acatcgtgtg tgcggcatac ctcacttaat 1840321 ctctcataat atcccggagg cggagtaatc gctgctcctg cagcaccaat aataggctca 1840381 gccacaaagc cggcgatgaa ttggcttccg attcttttaa tcatggtgtc cagttcatca 1840441 gctgcagtct gaacaaagtc ttcttccgtc tcgtgattca gccgataaat atgtggagct 1840501 gagatagctg gataccgctc aatgagatgg gtgaaccggt atctcctttc ataaaaacca 1840561 gacaatgaaa gcgctcccaa agttattccg tggtaactgc tccatcgaga caaaaagatg 1840621 gatttttgtg tttgcttttt ttcctgccaa tactgaatgg cgattttcat agctgtttct 1840681 atcgcttctg atccgctgtt gacaaaaaaa gaccaattca catctccggg cagctcctgt 1840741 gccaagagag cggctaattg ctcggcgggc tcactcgtaa actgtgagcg gtaagcaaaa 1840801 gacacctgat caagctgttc tttcagcttc tcagtcacat cacgaactcc gtggccgata 1840861 ttacatgtca ccgcacctga cgagccgtcg agatattttt ttccggtctg atcataaaca 1840921 tatgaaccct tcgcataact gacaaccgga taggccgagc taagctctgg cttaatcaaa 1840981 taactgctca tgctcccacc tcaaaacccc ttttaccata ttgtatgagt gtccaaatgg 1841041 cggcatgacg ttccccgcaa aaactttttc acataaaaag agccttccta ataaggaagg 1841101 ctcttttgaa atttcagcat ctagcaaata aaagcggctc caacaataat taataaaatg 1841161 aacaagacaa caattaacac aaatgtattt gtcccgcagc caaatccgta accgtaccca 1841221 gagtatccat acatgctgtt ttcatccttt cttatcacga tatacgacat tttatgcggg 1841281 ccaagtccca aatggtttgt gcaaacgcct atttcatgta aggaaataat gaaatacagt 1841341 atgcacccgc tcatattttt taaacgtcag cttttcgtaa aactgagttg caccgtcagt 1841401 gcttgcagcc actaagtagg ctgcttccat tcctagtgat ttggcgatgg acagcatttc 1841461 tttcactaag atactgccgt agcccttcct ttgaaactga tctaaaattg ccacttcttc 1841521 gattttagcc gttttctctt gatgatcgat aaacagctcg ccgcacccaa tgggaacttt 1841581 ctgtgcctgg tcgctgtaac aaacaacaag aatgattata tctgcttcat agaaaggata 1841641 ttttcttttt aatttttgtt cagcgattgc ttctccaata taaatggaat cgtaaatttt 1841701 cataatagaa gatccgtcgc taagactttt tgccgtcccc catgcggtta aaggatgtcc 1841761 catctgcccc ttccagtcac taagcttcat gtcatatagt agctcatcct cgacgacaaa 1841821 accgcttttt acaagtgact gcttcaaacc gagcggaaaa acatgctgcg gcgacgcttt 1841881 taaatggaga taattcgcat caagcagctt tggtacggag ggtaaaaagt taagtaaccg 1841941 ctccaatgga aacgtatcat ggagctgaac aaagttatga gaaaaaattt gcggaagctg 1842001 cggatctctg tatacgctgt aatgatcaaa cgatgccgat tcagacgtta acaatatata 1842061 ttgatgttcc gtttttgaat aatgtcctgt catgaacgtc tcctttttat gacctatacc 1842121 tttactctgt tgcaatattc aatttcttta taatctcatc gtacaccgga taaaacggct 1842181 ttccaattgg aaattgctga atatttcgga aagaagcgga gattggcttc tgatgtaaaa 1842241 aaaacttcct tgttacttgt tcactaatcg ggtgaaagac gccgtttaga aacaaaaacg 1842301 gctcgcgttc gatgaaaaac agacgtcggc caggcggatt tttgatcaat tcagatcgtt 1842361 tccacgtaat cggcggccct tccggaagcg tctccatctc ttcttttcca attgtcacta 1842421 tgtcttttct ttgaaattga taaaattgaa acgcatactg gtccacaatt cgcctttttt 1842481 ttccggcttc gatataaaat attgcaggat ggtcagcttc ctttactaaa atataattcg 1842541 gaatgtttaa aattttgcca atcctatatt ggaataaata tgggtctgga acagcgacag 1842601 tccgatttag atacaaaaaa ccccactttt ctccaacagg atgccttaca ccctgatcaa 1842661 aaaaatacac attttgatct gaacctttta caaaagagcc gtcaatcaaa tcggcgggca 1842721 gaaaccgata tgcattttga aatgaatctg gggttttata ggttgtgtct aatacttcat 1842781 ttatcggcag aaatggggta aagttgttga gtctcgccca aaaaattgcg tcgccatgat 1842841 tccaatgctt catatcatca tcccagtagc ctccaaattt atggtgaatg agattaagta 1842901 acgaacggcg atgcataact gagcaatgat caacttgaaa agcggcctga tcaagcactg 1842961 cattggcatt tctgtagaaa tgtgagattt cctctcccct ttcgtttaca tgtacaactt 1843021 tttgttttga atagaccgcc tgcgcttcag gcttatgtga aaactcttgc accatacggc 1843081 tcagccgctc aggatgataa acagtgtcgt cagtaagata ggaaatgtaa tcgccgtctg 1843141 caaatgggag cgcactgtta attaatgtgg cataacgggc tgtttttaat cgatctgcag 1843201 gatgcacgaa actgttatga tattgaatgc gccggtcatg gagatacttg tgaatcaccg 1843261 cagttgtttc tgcattcgaa tgatcatcca tgataaaaag ctcccaaaga tcatgcgttt 1843321 gctgtatcac gctttcgatc gctttttgca aataatcggg tttgttgtaa cttgttaaaa 1843381 taatagacac tttctctccc atctataccg cctcccgccg tcaaacataa aaacggctcc 1843441 gcagcaagca gagcctctgt catcatttaa aaagcacccc agcttacaac acttgagagt 1843501 gaaacatgag atctcgtgtt atttaacggg ttttggaaaa taaccaaatc agtcagaact 1843561 tcttttacga tgacattttg aagtgtatct ccgttgatca aattgacttt tgaaaccggt 1843621 acgcccagct cttttgcaaa aacaagctgg cgtctgaggt cagatggatt tccttcagaa 1843681 gacgattgac gtatcagcag aatcagcaaa agcaaaataa aatgcagatc atcttggttt 1843741 tcttctcgat ccacttgttt ctctaaatcc aaatcatccc tctcccttat ccttatctct 1843801 gtttcacaat atgtgcgact tcgatttatg gtataggcta tgtccactcc attaaaaaat 1843861 cagcattttc cttaaataga tgaaaaatag atcaggtacg gcgttcgact cataccaaat 1843921 aacagccgga agaatatgaa taacgtgagt tcactatcga ataggaggtg tgtgtaatga 1843981 gctctgaaaa tgcacagtta aaaaaggatt taattaaagc cgttttaagc cctttatttc 1844041 caactgcaac agaaggagga gaaaatatgg atagtaatct taaagccttg cttgatgctg 1844101 ccatcgatca aaaagtagat gaaagtgaaa cggttacggc agaatctatt ttagaccctt 1844161 ctcttccggc aagatggatt tttgccagaa ttacgccagg cactacaatc agcattgtga 1844221 ctgattcagg tgacatgatc ggaccggttg ttttcgttgc tttcgatcag gttcacggga 1844281 tcgtatttgt aacacaggaa agctccgtca ctccggcagg ccaagctaca acattaattg 1844341 atgtagacaa agtagaaagc gttacgttct tttcataaca tccgatgaaa gtcttgtata 1844401 tccagtcggg atacggagga atatacagtt attttgatcg ctgggctgaa gaatgttttc 1844461 agaacactca tacagagtat atgattgcag ataaacctga agcagaatct ttgatgaaga 1844521 tcgaagcgtt tcagccggat ttcacactta tgatggttgg agaccgcgtt cctcacgact 1844581 ggctgacctg gttaaagggt aaggatatcc ccgtgtatgt ttggctgacc gaagacccat 1844641 tttatatgga tatcagcctt caggtaatta agcttgctga cgccatatta acgatagaac 1844701 aaaatgcagc tctctactat caagagctcg gctaccagaa cgtctattat gttccgatac 1844761 cagttaacca tcggctgttt aaaaaaatgg gcaccgaaca ttcctatcat tcaaatctgt 1844821 taatcatcgg ctatccttac cctaatcggg ttcagcttat gaaagaagcg gtccatctgc 1844881 cattcacggt tcgggtaatc ggcaaggaat ggggaaaata tctgcctaaa aaagtgctca 1844941 aacagccgca tattgatgtc gtcagcacat gggttccacc cgaacaggcc gttcattatt 1845001 ataatggggc agacatcgta attaatgcgc atcgtcccta tcattttgct ttcaaccaaa 1845061 atactatgcg catcaaaaat gccagtttta ataaccgaac gtttgatatc gctgcatgcg 1845121 aagcatttca attaacagat ttacccgcgg cgcatccttt ttcatccatt atttcttatc 1845181 acggcatgaa cgactttaag gaaaaagccg ctttctatat caaccaccct gaagaacggc 1845241 aaaaagctgc agcagccaat tataaagaga ccgtacccgc atttacgttt gatgagcttc 1845301 ctgcaaaact aaaagcgatt catctggcgc tttcttgaaa aatcgttcat tgctatgaac 1845361 gattttttta ttcatagaaa aaagcagctg cacaagctgc tttctattct agccgtcaga 1845421 acggtctttc agcttcctcg gatttacctg tttatgaaga tcaggcattt cgccgagatg 1845481 ctgtgcaatt tgttcccacg atacaatttt gaaattttga ttgacggctt gtccgttatc 1845541 aatattttcg ccgtcctgcg ccacaaaaat cccgtacgga tattttgggc caagtccgaa 1845601 accgagaaca tcaataccat ccgtgtcact agtaccgtct atcttctcgc catctgtaat 1845661 ctcaaagttg gctacatagc gatttttccc ctgccgttca tacattgcat agctgttatt 1845721 tccttgactt gaagccatga gatatccttt gccatttggt gcataataga ttgtcagtcc 1845781 ttcaatatca gctgtcaaat gatctcctgt cgcacggtca acaacctgcc cctttgaccc 1845841 tccgccgggc tcagcgttaa atttccagat ggcctcatct tcctctgcta tgtataggtt 1845901 tccgtactca tcatccgcaa caaggccttc ggtctgagaa ttcaacttaa attcacgcac 1845961 ctttttccct gttacataac cctttccacc atcaacaatt tcatactgct caaattcccc 1846021 ttgtttgcct gtcactaatg cgtaaaatgc tcctgttttc tggctgtgat acaagctgaa 1846081 tccataaacc tcagaaatat tggtggaaat aggatggttc ggatctgtaa tgcttttcaa 1846141 ttttccttta tccccgtcta ttgcatatac ttcaattgta ttttttcctt cggaccggtt 1846201 ggatgcggca gcaatatcaa ttttttcgcc gttcaatgga aaatcatagc gcagatcgac 1846261 attattgagc ttgccaaact cataagaatg aagctgtttt ccgtctaaat catacacaac 1846321 gagccctgac ttcttatttg ttgtaatcaa cttgcttttt tccgggtgtt tttcatgaac 1846381 ccaaatggcc gggtcatctg ctgcatcatc gccagatgcg accggatctg tctccgtgtg 1846441 tgcagtcact ttgaaatgat gttcctcatt cacataatga gccgacaccg aggttgctgt 1846501 caggctaagc aataaacccg cggcagtgct tagcagcatt gtttttggaa ccttcatttg 1846561 gtaccctcct cttttatcac taacactact attgtaaaat atatacaggt gattaccgtg 1846621 aggaaaatga accttttttt atagggtttc tgactcataa acaacttatt ccccaaagag 1846681 gtggtgagat gactttgcca gatttacttt tgcggagcga aataaaaata tgttgaatat 1846741 ttagtacatt atttatttag ttttgttttt ccctagttac gtccgttttt ccattttcta 1846801 ttaaaaaaga acactttgtg acatgatcat tcccctaaat tttgttttat tggttgcttt 1846861 cattaattcg attacaaagt tgaacatatg atgcatggta gagaaacgag agttggagga 1846921 taagccatgc ctaaacagca aacagcagaa ctaaaaccat ttttccataa caaaacagtt 1846981 ttagtcactg gcggaacggg ttcaatcggg agtcaaattg tcaaacgcct tttgatgctt 1847041 acacctaaac aggtgattgt attcagcaaa gacgacagta aacagtatgt catgagccaa 1847101 aagtatgcgg aggataagcg gctattattt gtacttggag atgtacgcga tcacagaagg 1847161 gtgaatcagg tgatgaaagg cgtcgatatc gtctttcacg cggctgcgct gaaacaggtt 1847221 ccgacatgtg aggaccatcc atttgaagcg atccagacca atctcatcgg cggacaaaat 1847281 gtggtggaag ctgccctttc acaccgagtg cagcatgtca ttaatatcag tacagataaa 1847341 gctgtatctc ctgtgaacac aatgggtgcc accaagctgt tatctgaaaa gctgtttcat 1847401 caagcaaacc gccacgtcca aaacaaagga accttgtttt gttcggtccg ctttggaaat 1847461 gttctcggtt ccagaggttc ggtcatcccc atattatttg aacagatgat ggagggtgaa 1847521 cctctgacca tcacagacaa aaacatgacc agatttttca tgtcaataga cgatgcagct 1847581 acattgacat tacaatcggc tgctattaca aaaggcggag aaacctttat tttcaaaatg 1847641 gaatcactga aacttgaaga actgattcat gggtttgaag aatatgcatc gcagcacggg 1847701 ctcccgcggc cggctgcagt agaagtgggc aagcgtccag gtgaaaagct tcacgaagaa 1847761 ttaacatctc cacatgaaat tgaatcactg tatgaatggg gcaaccttta tgcgatcctt 1847821 ccagagccgg aaaaacatcc tgactttcgc aaagtcaatc tgcctgggta tcaatcagat 1847881 caagccccgc tcattacgaa agaaagaatt gctcagatta ttgaagaatt gcatcaagag 1847941 aaaaaggcat aaaaacaagc ctgtctatcc attaggcagg cctgttttta acagtttatt 1848001 tattaaagag atgcagatag ctttcgtatc cttcttcttt tagcttatgc ttcggaacaa 1848061 accgcagcgc tgctgaattt atgcagtaac gaagtccgtt tggccccggt ccgtcattaa 1848121 atacgtggcc aagatgagaa tcagcagttc ggcttcttac ttctgtgcga atcatgccgt 1848181 ggctcgtgtc cagtttttct tccacttctt cttcaatcgg ctttgtaaag cttggccagc 1848241 cgcattggga atcaaattta tctttggatg taaacaatgg cttgcctgac acaatgtcta 1848301 catacaaccc ttcttcctta tgatcccaat attcattttg aaatggcggc tccgtgccgt 1848361 tattttgcgt tacttcatat tgcatgcgat ttaatgactt tattttttct tctttattgt 1848421 acgccattta tttagccccc caatgctcgc tgataaatcc cgctcgtccg gaacctgtcc 1848481 ggtagcgctg ataatgtgct ggattctttt tataaaaatg ctgatggtag ccttccgctt 1848541 catagaaagg ttcagctttt aaaatgtccg ttacaatcgg atctttaaag atgccgcttt 1848601 ccgccagacg ttgcttggaa gcttccgcaa gctccttttg tttatcatta tgataaaaaa 1848661 tggctgcgcg ataggaactg ccgcgatcag caaattgccc tccggcatct gtcggatcga 1848721 tttgctgcca aaataattca agcagttttt cataagggaa tacatcagga tgaaacgtga 1848781 tttgaacggc ttcacgatgt cccgtcgttt cactgcacac ctcttcgtac gtagggtttt 1848841 cagtatggcc gcctgtatac ccggacacca ctttttcaat tcccggctgt tcgtcaaaag 1848901 gtttaaccat acaccaaaaa cagcctcctg caaatgtggc gatttctttt ttttcagaca 1848961 tactggtgcc tcctttgtta atacgtggta ttattatatt atagcatgta aaaatagaat 1849021 gaaaatgatt ctgcttttca ataaaatcta taggttttaa gcaatatgct tatgtaatgg 1849081 aggttcacaa atttgaaagt aagaacacag atgatgtacg atatggaaac tttactccgt 1849141 aaagtcttta aacaaatacg caatgaaatc aatgaaattt tagataaaga gctgtcgcgg 1849201 aatgaattca ccattcttcg aatccttagt gaacaagggc ctaaaaaagt cactgaattt 1849261 gcgcctattt tagaggtatc ggcaagccac attacggctg tgaccgatgc gctggtagaa 1849321 aaggaatgga ttacgagaat cagatcgaag gaagacagac gcatcatccg cattcatatc 1849381 actgaagcgg gcgaaaaagt ccttcagcac tttaacgaga aaaaaacgga atatttcttt 1849441 aaacgctttg actgctacac tgatgctgaa cttgccacgt taatcgagct cttcagcaaa 1849501 cttgataaaa aacggtgaaa aaaagcacat accgatatat aggtatgtgc ttttcgcagt 1849561 gcttcactta tttttcagta aacagcttca ttgctttcca gcggccatat ctataataca 1849621 aaaatgccgc gcagctgcta aataaaaaac tcattccgat tccaagcccg attccttttt 1849681 gtccaagcca agctgaaaat agagctgtga aaggatacct caacacccaa aacgagatca 1849741 aatttaatac cagaacctgc agcatcgctc ccgcggccct gacgattccg ttcagcacaa 1849801 aattaacccc aataaaaggg tagaaaaacg cgatccactt caaatattgt tcaccaaatg 1849861 cgaccgcatc aggctcactg ataaataacc ttatgaggta tttaccaaat acccaaatca 1849921 taaccgcaat caccagcatg caggaaataa cagctatcac acctagcctt gcaattgttc 1849981 ccactctttt ttcgtttccg attccaatat tttgccctgc catactattg acggccgtac 1850041 cggcagccat tgctggaagc gtgatgatgc tatcaagccg ctgcaccgcg ccaaagcctg 1850101 ataccacgtg atccccgtat gagttaacaa cactcataat cgccatcata ccgcctgtaa 1850161 tcaccatcat ctgcagacct gccggaatcc cgagtttcaa aatcagcgcg gactcttccc 1850221 acttgggcat tctcggaatc gagaatggca caagcttgtg tttgatgaca taaaacaacc 1850281 catacaaaaa cgcaatgccc tgtgacaaaa tcgttgaata agccgctccc gctattccca 1850341 tgcggaacac agaaataaag agcggcgcaa gcactgtatt cagtacaaca gcaaacgcaa 1850401 taaaccggag aggtgtcttg ctgtcgccca gcgcacgaag cacagtactg ataaagttat 1850461 aaccaaacaa aaataaaatg ccgataaatt gaatctgtaa atacgtctca gcaagcggta 1850521 tcattgactc cggcgttttt agaagacgca gcaaaagctc tgagagaaaa aaaccggccg 1850581 cgccgaatcc gatgcttagg cctgttaata aaacaacaaa agcgttaata tacgacgcca 1850641 ttccttttat atcatctttt cctttttgct gagataaaat ggttaacgtc gcattgttaa 1850701 ggcccaaaat aaaagacagc acggtcaaaa caatcgtgct tgataccgcg gctgccccaa 1850761 gggcctttgc ccccagtaaa ttgccgatcc acaagctgtc tataaattga aaggaaacct 1850821 gcaatgcgtt tccgagcata ataggcattg aaaacagtac aagctgtttc agcacgttcc 1850881 cctgtgtaaa atcgtatgct ttcatctttt ctccttgtgt tctcaaattt tcttcggacc 1850941 acacgaaaaa agagacgttg tttcatgtct cttttttcat gacttatcgg ttttttttcg 1851001 gtctcgcata ccgaatgtaa acaccatcac acttaggaac aaggcacaat aggaaacatt 1851061 caaatacatt tgatccatat cttcagcagc cagatgatga taagcaagcc agccgaagta 1851121 cagggaaaat gtaaaggata ataaactgaa atactggtaa atccgtttca ttttcagtca 1851181 cctctattgt ttaggatggt aataggaaaa ctcaatttca tctttttcta aatttatctt 1851241 atccgctttg acatacattc cattcgttaa aggcatttct gacaaacgca cttcaatgct 1851301 tttatctccg gggtgaacat ggacaaatga cggcaattca taaaagctgt ccatataatt 1851361 taacacaaag ctaattggta tactcaattt ccctaacgaa aatttcgtga cattcagctc 1851421 tacatcaccg ttttttttca cggtcggctc aaaagcgata aacgcatcaa tagacgtgga 1851481 aaatgccttg attttccctg cgacatgaac atcatcatca atctctactt tataatcaag 1851541 cttgtttgat gctttgtcgt ttaaatatga gttaacaaac gcagctaatg attcttttgt 1851601 gcttgtcact tgaaatccat actcgctctc agatgcatct ttcacctgag cctgttcccc 1851661 cggaagcaaa acaagtgcca caaacccggc ggcgaggata aaattgattg caagcaatat 1851721 aaaaaacagt cgcttccact tattcatgct gtcaccctac tctttcggta atccttcttt 1851781 tttaatggct tgatagacgc gctttgcgat aagagaataa cccgtaccat taggatgaaa 1851841 atcatcttcc tcagaaattc ggctgctgtc acttttttga ttaaacaaat cttcgatatg 1851901 gacgattttt gcatgtttat cttttttcag ctctttttca gcaatatggt tccaatccgt 1851961 gacgacacca tttatttcat ttagttctga taatgtaaac gtaaacggat tgtacatgct 1852021 gacataaatc agctcagcgt gatcattcag ctcgcgaatt tcagaaatga ttttttcaaa 1852081 gcgcttttcg tacggttttt ccgcttcctg aaacggttca acggttaatt gcagaaagtt 1852141 ttggcgaagg attttcatca aatcattacc gccaattgta aaaaagacat aatctgcgtc 1852201 ctttatgcct ttttgaacct ttttatcttt tagtttttct aataaatcat ccgaacggtt 1852261 cccttttaca gcataatttt tcacgtcgac cgttttgact tgtttatctg accggataga 1852321 atccgccacc ttgccgacat atccctttcc gtcgggatct ccgactcctt ctgtcagcga 1852381 atctccgaca gccgctatga caatgtgttc ttttgttttc gtttcatggg ctttttgttt 1852441 tccctcagat gatgtacgta tgctcgtaca cgcagtaaga agcaaaatca aactggccat 1852501 gattgaaaaa atgcgcagct tcaatcttgt tgctccttcc cattctacta gtggaaagtg 1852561 tatcatgttt tagaagattt gcaaatgcct agtctcttag cttacttgag tgtactggct 1852621 gacttcacat cggaaatgat atcatcgtac ggtgtattct ccactccatt gtaatctttc 1852681 agcaccttac cgtccggacc taccaaataa aaagaagatt gatgaatcac ttggtcctct 1852741 ccctccggct tctttacgat cgctttaaag ctcttaagtg cgaactcctc aatctcactc 1852801 tggctgtatc ccgtgagaaa atcccagtta tcaaaagata atggataatt tgcggcaaat 1852861 ttcttcagct gtttcggctt atcgttttct ggatcaacac taaatgatat gatgcggaca 1852921 tctatatttt cggctttcag ttttttttgc agatcggtca tatgagcggt cattggcgga 1852981 catatagttt cacaattggt aaaaataaaa tccgccagcc atacttctcc ttttaaactc 1853041 tctaaagaaa cgttcttgcc gtcttggttt tgaaatgtaa aaggctccac ctcgtaattg 1853101 agcggatctt taatctgctg tcctccgcat gcacacaaaa acagaaaaat cagcccagcc 1853161 gttaacccct tgataacctt catgacatcc atcctttcca gccagcataa aaacgctttc 1853221 taaaaccgtc cttactgtcc catgtttgta ttcgatactg agcaaaaaaa atcctgcatg 1853281 cctccccatt aacgattaca aaggagggca tgcaggtaaa aaacggcatg ttacgcgttg 1853341 tgctttaaca cctcttgatg aaatacagcc tgataatctg cccacttcat ccgccgcttc 1853401 atataatgtc ggaaagaata cacttttgcc ctgctgtttg atgaaaacac ttcttttaag 1853461 tagaattgca aatggtgatg taacataaag aaatagtgct catcttcctt taatacaggt 1853521 atttctgtca ctttcacctg aatcccgtca ccgcgtttga actctaggct tttgagtaac 1853581 aagctatcaa tcctcttttt tgtttttctt ctattatata tgatgccagc cgggctgtct 1853641 gtcattttgc gcggttgtgt aaaaaaatta gattagcaaa tggaacaagt cctcatcctt 1853701 gttcacctct acataatgaa acggtttttt gttcatccgt tcaatcagcg gcccataatc 1853761 ggctttgttc tgcagctcga tgccgacaag agcaggtcca ttgcttttat tatttttctt 1853821 cgtatattca aaccttgtaa tgtcatcatt cggcccgagg acttcgtcaa gaaattcgcg 1853881 gagcgccccc gctctttgtg gaaaattgac gataaaataa tgctgaaggc cttcaaaaat 1853941 caaggaacgc tccttcattt cctgcattct tccgatatcg ttattgcccc cgcttaccac 1854001 acacaccacg tttttccctt taatttgatc cttgtacaaa tcaagcgctg cgacagaaag 1854061 agctccagcc ggttcagcaa caaccgcaca ttcgttatat aattcaagaa tggatgtaca 1854121 tacttttcct tcaggcacaa ggagaatgtc atcaacgaca gtttccagcg tccggaaggt 1854181 ttcctcgcca atttttttaa cagccgcccc atctacaaac ttatcaattt tatcaagtgt 1854241 gacgacatgc ccagctttgt ttgattcaaa gtaggatgcc gctcccgccg gctcaacagc 1854301 aattaccttt gtatcaggag acacgttttt caaatatgta cctaccccag agagaaggcc 1854361 gccgcctccg acacttgcaa aaagaaaatg cggttctgta tcaatgtcgt ttaaaatctc 1854421 gactgcgagc gttccctgtc cggccatcac atccggatca tcgaacggat ggataaacgt 1854481 ccgagattcc gcctcacagc attcagcagc gcttttatac gcgtcgtcaa acgtatcgcc 1854541 tgtcaaaata atatcgataa atccttttcc gaatagttca acttgagata ctttttgtct 1854601 cggtgtagta gacggcataa aaattttccc gtgaatgcca agatgtttac acgaaaatgc 1854661 cacaccttga gcgtggtttc cggcacttgc acacacaact ccgttctctg tctgctcgct 1854721 ggaaagctgt ttcattttat gataagcccc tctgagctta aaagatctga caacttgcaa 1854781 gtcttcgcgt tttaaataga tattgcattc atatctctca gaaagtctgt cattcctctg 1854841 caaaggtgtg tgaatgacaa cgtcctttac gttttggtga gccttcaaaa tgtctttcac 1854901 ttggatgaga gagttttctt taagcaacgg tttcatgtac agattccttt cttgttttaa 1854961 atccctattt aatatgccat tataacatga atattcaaaa aataagacaa ttatttttat 1855021 ttaataatta aaaaaataca gactatgtcc accacatctt gtggtaactt ctgttcaacc 1855081 attatcctgc agagccaaga aaaaagatga tcgtaaaata aagggtgttt tcaaccaaaa 1855141 ggcatgatat aatgaaacca attagaacca aaaggagcca attgatgaat agtgcaccaa 1855201 aactcaatac atttcaacat ctaatcggag aacatcaaac ttttctggaa gcgaagcgaa 1855261 tcgccaagca gttctcgtta tcggagcttc ctgtcttaat aacaggaaaa atcggaacag 1855321 gcaaaaatca cttcgcacat gccatacact tggaatcttc gagaagcaat gaaccgttta 1855381 taagcgtcaa ttgcagcacc cattcggaag aaacccttat tcatgagctt tttggcccta 1855441 acggaaacac aggtgttttt caaaaagcgg tacgaggaac cctttttctt gatgatgtat 1855501 ggcgcatgcc tgcttctgta caagctcagc tgttaaaagc gcttgattca gacacggaga 1855561 aaccgcgaat gatctgtgct tctgcagacc gatccgtgga acatacattc aggcaagact 1855621 tattctacag actgaacatt ttaacgctca cactgcccga attatcggaa cgaaaaagcg 1855681 atattccgct tttgacacag cattttctct caaattctgg tcagcaattg ttaatcgatc 1855741 cctccgtttt tcccgtgctt gagaagcatg catttgaagg caatgtcagg gaattaaaaa 1855801 acgctgcaga ttatatggcg gcagtatcaa gcgggggaac gattcagcca tatgacctgc 1855861 cgccgtatat tagaggcacg atagacggaa aaacgtcgaa gaaaaaagcg aaactgctta 1855921 ctttaatgga aaaagctgag tttttgttta ttttggaaac aataaaagta ttgaacgaaa 1855981 aaggagaacc tgccagcaga cggatcattt ctgaacacag caaaaatacc caaacctcgt 1856041 taactcctca gcaggtcaga agccgtctcg actatttgga gaaaaaagat tatgtcacca 1856101 aaagccgcgg acgcgcaggc acaaaaatta cctttgaggg cttgagcttt atagagacgt 1856161 taaaaaatca aatgatctag cgatcgaaag gagaatgtac ttgtttacaa tcaaagaaga 1856221 gatcgccaat gcgattacac acggcatcgg tgtcctctta tccatcccag cattagtgtt 1856281 tctaatcata tttgcggcta attacgggtc tgcatgggac attgtcagct ttacaatatt 1856341 cggtgtctct atgctgctgt tatatttgag ctccaccctg cttcacagca tcacacataa 1856401 aaaaacgaag gacattttgg agattattga tcatagcgca atttacgtac tcatcgccgg 1856461 aacctacacg ccttttttgc ttgggccgct gaaaggcaca ctcggcttta ccctgttggt 1856521 tatcgtatgg tcacttgccc taggcggaat cgtttttaaa attttctttg tgaaacggtt 1856581 tatcctattg tcaaccttcg tgtatttagt catggggtgg ctgatgatta ttgcagttaa 1856641 acctttatat gcttcactga gcggagcggg attcagcctc ctttttctcg gcggcatttt 1856701 atactctgtc ggaaccatct tttacatttg gaaaaagatc cccttccatc acgccatttg 1856761 gcacagcttt gtattgggcg ggagcgctgc catgtttttc tgcgtgctct tctattgtgt 1856821 aaaggtgcct ttcctttcgt aacagtaaca gaaaagcgca gtcttcacga ctgcgctttt 1856881 ttatgcacgt aattgttttt cattggcagg tatataagct tttgaaaagg acaattcaat 1856941 gtctgccggt tttaagcgtt taaaaaacga gccattttgc atgttatctg ttcctttcgt 1857001 ttccaccatc accaacggaa gatgatagcg ggccgcaagt tctacaggat caatagaacc 1857061 atctagtgaa agaatcaggc tttgtccctt ttccagctgt tttgtcacat cttcatatac 1857121 cttttctgaa tccccgtctg aaatcacatc catccgatcc agccattgcc cgataaaagg 1857181 caagcggaac acttttgggt tagcgataaa gccggccggt tcctcaatat atccagcaat 1857241 taaggccagt tcagccaaac gcaaacgggg atgcacatac aaaacaggac cgtgtggtat 1857301 tggctctggc tgatggatcg tcacaactga accggagatg ccgatacagc cttctaaaaa 1857361 cgcctttggc tgttcgtaca caagagccat ctgttttttg tatgacagac ggggatcgag 1857421 cattgtttga ttaaataatt gtttcatatt ttttaacagc atatacacaa tataaaccac 1857481 tagaaggctg tagcgaacca attaaaatcc tcccgcttta gaagaattct ttttttcata 1857541 cattagaaat tcgtaatcat acgggttttt ttcgtctttg gtcccctgct cagaagaaac 1857601 cagcttccaa ttggattcat caaattcagg aaagtgacgg tcaccctcaa actcgtgatg 1857661 aattttcgtc atatacagtc tgtccgcata agggaacagg tccgtataga gctgagcccc 1857721 tccgatcaca aagcattctt cagggcctga acaaatgtcc agtacatcct ttaatgaact 1857781 gacaaccgtg catccctgaa attctgaatc cggcgctgag gtaacgacaa tatttttccg 1857841 atttggaagc ggacgtccga tcgattcaaa tgttttccgg cccataatga ttgaatggcc 1857901 cgatgttatt ttcttaaagt atgcaagatc attgggcaaa tgccacggca aatcattgtc 1857961 tttgccgata agcctgttgg catccatcgc aaaaatgaat gaaatcatac gctgaccgcc 1858021 ccttttatat gaggatgcgg atcataatcc tcgatgataa agtcctcaaa tgcaaagtta 1858081 aaaatagaat caacctttct ggcgaaacga agctgcggaa gcggtctaac atctctttcc 1858141 agctgcaaat tgacttgttc aatatgattt tggtaaatat gaacatcacc aaacgtatgg 1858201 atgaactcgc ccggttcaag cccagtcaca tgagcaatga tcatggttag gagggcataa 1858261 gatgcaatat taaacggcac acctaagaaa acatcggcag agcgctgata cagctgacag 1858321 gacagcttgc cgtcagacac atagaattgg aacaggcaat ggcacggcgg caacgccatt 1858381 ttatcaattt caccaacatt ccaggcgctg acgattaagc gtctggagtt cggatttgtt 1858441 ttaatatctt caataagacg ggaaatttga tcaatggttt ctccatcagc tccccgccaa 1858501 gaacgccatt gggagccata tacaggtcca agttcaccgt tttcatcagc ccactcattc 1858561 cagattcgca ctccgttttc ctgcagatag cgtacattcg tatctccttt taagaaccac 1858621 agcagttcat gcgcaattga tttaaagtgg agttttttag tggtgagcat cggaaagcct 1858681 tcccgtaaat taaatctcat ttgatatccg aaagtgctga ttgttccggt cccagtccgg 1858741 tctccctttt tctcaccatg ctctaaaaca tgtctgcaga aatccttata ctgtttcatt 1858801 tttttcatcc tttaaaagta gtcttctagt agtgtaacac aataaaaaat catttctgaa 1858861 cccagaaatg atttttttat agtcagctga cgacaggctt ttcatcctgt tctttttctt 1858921 catcttgcag atcctgatgc gtatgtgcaa ttctgctcgc cgctgctgca gcaagagctg 1858981 ccacaatatc atccaaaaag gtgtgaatac cgtctggact ttcatcaagt tccttaataa 1859041 ttccaatctt ctctttatcc aaataaccga aattggtcaa accgatcgac ccgtacacat 1859101 taacgattga aagcgggata atttcatcta tgccgtaaag cggttcatcc gtttcaacaa 1859161 ggtgctgcag cggttcgggg agaagtttct gttctgcaag ctgatcgagt gcaaggcctg 1859221 tcaaaacagc atgaataatt tcacgtttgt tcaggacttt ttctacattc tccatgcaaa 1859281 cactgagcgg cagatttgga ttgtattttt cctgaagttt ttgaacaatc cgtgcaatat 1859341 cttctatcat aacgccccgt ttgttcagca tatcctttgt tatatcgacc atttcattca 1859401 ttgtgtactt tttcatgtct aatggcatct cctttaggca ctcatccagt tgggaggcgt 1859461 gttgcggtcc cagtaaatgc tcccaagctc atgatgtgat tgaaatccat cttctgctgt 1859521 atgataatga aaattaaacc agtagccgtc atgaggcggg tggtctcttc gcacatggaa 1859581 tctgagaaga tcttctccag ttgtccgatt gtaaacgttg aaaatttttt ccgttttgcc 1859641 cgctgaaggc atgcttgaga tcacaacatc ttggtacgcc tcatcatctt gcaatgtcgc 1859701 taaataatca ctaatcacat tttcgatttt tggcaggatc tctttccgat agtcatcctc 1859761 aatgacagga gcgattctgc tgccgaattt taaaaaggac tgatcctcag cgctgtcaag 1859821 gagctgttcc ttgtacgatt gaaaaagcag ttcaggatct cgcctgtcat ccgactcatc 1859881 atcgtacagg tcatgctcat cataaaaagc ggtgtaatca ttctgctcaa gactgctcgg 1859941 ctgtccggaa ggcttgtccg ccataagggc agccggagga gatacgagcc cgaacgttac 1860001 aatggtaaat aaaaccacaa gggtctttct catccacaat ttcatgactg cttattcctc 1860061 tctattttat tgtcatgttt ctcttatttt agcacatcca aaacatgcaa gtcatgtact 1860121 atatgaaact gatatgcaaa ttaggagatt cgttgctatg cactttgtgt aaaaacgctt 1860181 acaatatttc atgaaaggag gctttccgca tgattgacgc tctgtttgcc acagtttcac 1860241 tcttaacatt attatacttt gtcgtcatgg aggtcaccga ttaacagaaa gcccgtgata 1860301 tgaatcacgg gcttgtttga atgacgccat aatggaacag tgctgttttt cttttcatga 1860361 cgttaaaacc aaactgttca aaccgcgggc ttttccagtg gtcttttagc acaacgcttt 1860421 ttctggcgac tcgtaccgct tcattgatac atccttcgtg caaaacggaa tcctctgcca 1860481 aatcacgtaa aggcgcgatg ccgtcagagg tttctacagg ttcatgaaac attggatcga 1860541 aataaaccac atcaacagag ttgtcaggga gctgcttgat gtgttcaaag caatcaccat 1860601 tcttcacctg gattcttctc atcgcagctt gaagctcttc tatacccgtt tcccatgaat 1860661 gcagccccgt cctcactaaa acagacacaa gatggttttt ttcaatccca acaacagaac 1860721 ccgtttcgcc tactgccata cttgcgataa tggcatctga ccccaacccg agtgtgcaat 1860781 ctaaaaacgt atccccttca gataagccgg cagcccgaag cataggttct ttctccccct 1860841 gtaagaagcg tttggctctg aacatcgctg tattcggatg aaaaaagaat ttggcacctt 1860901 gtttcgtata cagctcaaac cgctctttgc cgaccacaag caaatcacgt tcagctgatt 1860961 tcagcaggtg ctcaaccgtt tgtttattcc ggccgcagta tggcatattt agctctttag 1861021 aaagctgctt tgcagttttt atggtgtgtt cagacggtct atagcttgtt gttatcatct 1861081 tctgtactcc caaaaagaaa atgcccggag aacgggcatt tagcagtgcg catcgaaggc 1861141 agcagtcaga tttttcatga tttcttccat atcgtgtcct tcaatttcat gacgcggaat 1861201 aaaatgtacg acttctttgc ctttcaaaag agccattgat ggtgaagaag gctcctggcc 1861261 agtaaaatac tcacgcattt tcgcagtagc ttctttatct tggcccgcaa atacagtcac 1861321 cgtattgtca ggtgttttgt cattctggag gactgcctgt gtagccgcag gacgcgcaag 1861381 gcctgccgcg cagccgcata cagagttaac gactacaaga gttgtgccct ctgccttttc 1861441 cataaagttt tctacttctt ccgctgttgt taactcttca aaacctgctc cagtcagctc 1861501 gcggcgcatc ggtacgacaa gctggcgcat gtattcttca taagccattg acataaaaaa 1861561 agccccctct agtatccttc atctgaagta aaggatacta tagagagggc cggatttcaa 1861621 atgttcacgc cttaaaataa aagaaagtgt ccccagctat ctagattttc ataataccgc 1861681 cggtgttggc acttgtcaca agtttagaat aacgtgccag gtagccggtt ttcactttcg 1861741 gttcaaaacc tttccagttc gcttttcgtt tttcccactc ttcttctggc acttgtacat 1861801 ccaagatgcg tttttcaata tcaacgataa tatggtctcc gttttcaaca aaggcaagcg 1861861 gcccgccctc agcggcctca ggtgatacgt ggccgattga gaggccacgg gaggctccgg 1861921 aaaaacgtcc gtccgtaatc aatgccactt ttggcccgag tcccattcca acgatttggg 1861981 atgttggcgc cagcatttcc ggcatgccag gtccgccttt tggcccttcg tatctgatga 1862041 tgacaacgtc gccttctttt acttttcggt tgataatgcc gtcaagcgcc tcgtcctgag 1862101 aatcgaatac gacagccggc ccttcgtgtc ttgtaatccc attctgtacg ccgcctgttt 1862161 taatgatagc gccgtccgga gctagattac cgaataaaac agcaaggcct cccttttcag 1862221 tgaatggttg atccagcggg tgaatgacgt cataatcctt tacttcatgt ccggcaatgg 1862281 tttctccaag agtttttcct gtaacagtca gcgcatctaa atgaagcgct ccttctttct 1862341 tcgaaagctc attcagagcc gctgaaacgc cgcccgcttc gtgaagatct tcaataaaca 1862401 catccgatgc aggcgccagc ttagccaagt gcggcacgcg ctcagcgact tcgttaatgc 1862461 gttctaaaga gtattcaacg ccggcttcgt ttgcaagggc aagggtatga agaacggtat 1862521 ttgtagaacc tccgagcgcc atatcgagtg caaacgcgtt atcaatcgct tttactgtaa 1862581 caatatcacg cggtttgata tctttgcgaa tcgtttccat taattgcgca gccgattttc 1862641 tcacaaactc tttgcgttcc ggagatgttg ccagaatggt tccattaccc ggcaaagcaa 1862701 gaccaagtgc ttctgacaga cagttcattg agttcgccgt aaacatgcct gagcaagacc 1862761 cgcacgttgg gcatccgaac tgctctagtt cttgaagctc gttttcgttg attttccctg 1862821 cttggtaggc gcctacccct tcgaatactg aggaaaggga gatttttcgc ccgtcacttg 1862881 ttcttcctgc cgccatcggt ccgccgctga caaaaatcgt cggaatgttg atgcgcattg 1862941 ccgccataag cattcccggt gtgattttgt cgcagttcgg aatacagacc attccgtcaa 1863001 accagtgtgc ggatacaacc gtttccacag agtctgcgat aatttcacgg cttggcagcg 1863061 aatatctcat accgatatgc cccattgcga tgccatcatc taccccaatg gtattaaatt 1863121 caaacggaac gccccctgct tctctgattg cttcttttac gattttccca aactcctgca 1863181 agtgaacatg accgggaacg atatcaatgt atgaattaca caccgcaata aacggcttgc 1863241 cgaaatcctc ttcttttacc cctgctgcac gaagcaaact gcggtgcgga gctctatcga 1863301 ttccttgtgt gatcatatta ctgcgtaatt ctgccatggt gatcctccta aattctttca 1863361 attgtttgat tggattttat tttgacaatt ttcagtttat ttatgggctg tttttgcaaa 1863421 taagataaat acaggccgcc ctcaccttgt tttgttcttt cgtgttttta tatttatata 1863481 gctttctttc gatttgaacc ctccaactat taatattgtt acttactata aatagttttc 1863541 ggatattttt caacaatatt cgaaataatt tttataaaaa gtgaattcac ataaaaaagg 1863601 tgcatgatct gcaccttttt tatctttatt cgcctttttt tctgctttcc gtcatttgtt 1863661 tccaaacaga accttttgct tcttctccat gctcaatacg ttcaagcgcc attttgactt 1863721 gaaggctgac ctcaaattcg gggtcatctt cggcagcgcg caaagcttca attgcacttt 1863781 catcgccgac ttcgtacagg aacatggcgg cacgccagcg aacaagcttg ctggagtcgc 1863841 ttaatgactt gatcatagca ggaatggctt gaggatcgcc gatatcagac aggcagtctc 1863901 cggccgttct tctgactgat acagctttgt cctcaagtgc tttatacaat agaggaagaa 1863961 catcaggtgt ttcaatcatt cctaagtaca caacagcctg tcttctgatg gacacctttg 1864021 gatcatccaa tgccttctgt aaaaccggga tatcctcttc tttcggatcc atctgttcca 1864081 agtgtgcata acgctttttc cagtcctcat catccagcat atcaagcgtt actttatacg 1864141 ctttgcgctg tacagcttgt tttgcttcgc cctttccttg agcggctgct tcagtcagtc 1864201 gtttcagccg ttcatcactg tatgccgctt gaagctcttc tgtcacatca tggccgattt 1864261 catcaaagtc accgaatctg acaccttgtt ctttccaagc ccgctcaaac acaacattgg 1864321 aagcttcaga tctaagtttt aagatcgcct gctgaaagcg ttcaggtaag ccgaagcgtt 1864381 cttcccgctc tccatcggtt aatttaactt gcataggaat gccgctgaac atctgcacaa 1864441 aaacttttac ctctccaaaa gattcttgat cagaacgatt ttcttctgcg ctttcagcac 1864501 tttccatccc aaatgcagtg cggacttgcg gtaaaatgtc tttccagtcg tatcttgcat 1864561 tccgttcaac agcaagaaaa tctgcgacgt gatatacccc tttaactcca tctattttaa 1864621 ggatttccgc tataacaagc ggtgcgcctt ctgcttgctc aggtttatag ttattgcttt 1864681 tgcccgccgg aagctcttcc gttaagatga ctttcattgt attcgggctt ggtgtaggtt 1864741 caattgattt tatcttcatg atcgtcctcc tatagcatat ctgtgactta ttctatcata 1864801 gtcgctccaa gccttctatt acgacgtttc ggcatcaatc ccgggtatgt ctttttctaa 1864861 ttggcggaca aattgaagca taaaattgtg tctttcttct gccagttccc gtgcagtgtc 1864921 tgtattcatc atatctttca gccgcagcag cttatgaaaa aaatgagcgt aggcgctttg 1864981 ctcatctcca taaaggccat gcccttttgc gcccgcaaac atgaaagctc tcgcaatgcc 1865041 gacagcacca atcgcatcaa gtctgtcagc atcctgtaca gcttttcctt caattgagag 1865101 cggctccttc gccaatttcc ccctgtcccg aaaggacatc cttgttataa tatgaatcac 1865161 cctgtcagca ttctcttttc ctactccgaa aaaaacgagc tgatcatata cttcgctcac 1865221 agaaagcctg accgtgtcag gcagcttcac atcaattaaa tcatgaacca aagccgccgt 1865281 ttcaacaatg aacaaatccg ctttttcctt ttctccaata tacgctgcaa gatctgctac 1865341 tcttgataca tgatgccagt catgtccaga gctttcgtca gtcaggatag attgaaccca 1865401 tgtcctgatt tgctctgcct gcttcaattc cttcacaaaa acaccctctt tttattgctc 1865461 taatagcttc acgatatcgt cttccaactc tttcggattt gtatttggtg aataacggcc 1865521 aacgatttct ccatttctat ccactataaa tttcgtgaaa ttccacttga tcgccttagt 1865581 tcccagcatc cctttcgcat gttctgtcaa atacacaaac agcgggtggg cgtttttccc 1865641 gtttacatcc acttttgaaa acataggaaa tgtaacaccg taatttgttt cacaaaattc 1865701 ctgtatgtca gcctcttcac caggctcttg gttcatgaat tgattgcagg ggaaccctaa 1865761 gatctccagc ccctcctgct gatatgtatc atataattcc tgcagctgct tcaattggga 1865821 agtaaaaccg cacttacttg ctgtattcac gatcatcagt acctttcccg cgaaaggctg 1865881 aagtgtcatg tctttccctg tgattgtacg taccttcata tgataaatag acatgtaagt 1865941 ccctcctatg tccttggtgc tgattatttt acctttttta aatcgcaatt caaaatgtaa 1866001 acatcaatta agaactcata agaaacctaa cgatatgagc gtcagttcat tatcaattca 1866061 tatggctcgt tttttatctt atcattctat aaaacattac aattccctct tacatctttg 1866121 aaaatcattt tactgtgaaa ccaaaaggcg tgtcagtgcg ttttatttaa agagttttct 1866181 gttgtttccc cctcaacacg tatagataga ttgaaaattg gcgtgaaaat tcctataatg 1866241 aagaaaatta aacggggaaa taatggaggt ggcacgttgc ctattaatat accaacacac 1866301 ctgccggcaa aacaggtgct tgaaagtgaa catatatttg taatggatga aagcagagca 1866361 tttcatcagg atatccggcc gcaaaaaatt attatattaa atttgatgcc gaaaaaaatc 1866421 caaacagaga ctcagcttct cagattgctt ggaaattcgc ctttacaggt tcatttcaca 1866481 tttttaatcc caagcacaca cacgccgaaa aatactgcga gagaacacct tgacgaattt 1866541 tacacgactt tttccaatat ccgtcacaag aggtttgacg gcatgattat caccggtgcg 1866601 ccgatcgagc atttggcgtt tgaagaggtt tcatattggg aagagctcaa ggaaatcatg 1866661 gagtggagca aaacaaatgt cacttcaacc ttgcatattt gctggggtgc tcaagcaggt 1866721 ttgtattacc attacggtgt ggaaaaaatt caaatgccga aaaaaatctt cggtgtgttc 1866781 gaacataccg ttctttcaaa acacgaaaga ttggtaagag gttttgacga gctatactac 1866841 gtgccgcatt cccggcatac agatataaat atggaacagc ttcaagcagt gcccgagtta 1866901 aacattctta ccgcatcaaa ggaagccggg gtttgcttaa ttgtgtctaa agacgaaaaa 1866961 caagtctttt tgacagggca ccctgaatat gatacaaata cgcttcttca agagtatgaa 1867021 agagatttgg aacgaaacct ttctactgtc gaggccccta aacattattt tgcaaaaggc 1867081 agcaacgagc cagtgaatcg ctggaaagcg catgccacat tattgtttat gaattggctg 1867141 aattattacg tttaccaaga aactccttat gaatgggact aatttttctt tttttagtga 1867201 tacgctgagc aaaaaatatg ataaaataca tctgattcag tctgcgtata acaaaaattt 1867261 aaaatactgg aatccaaatc atttaaaatt agcttaactt tttcactgca ttaataattc 1867321 gattatgtat ttgtgttatg tttatgtata gacaataact ccttacgatg catgaagctt 1867381 gcttgttgtt gattacattg aggtgaattt acttgaatac caataaaaga gtattaattt 1867441 tgactgcaaa ttacggaaat ggacatgtgc aggtagccaa aacactttat gaacaatgtg 1867501 tacggctcgg ctttcagcat gtaacagttt ctaatttgta ccaagagtca aatccgattg 1867561 tttcagaggt aactcaatac ctttatttaa aaagcttctc aatcgggaaa cagttttatc 1867621 gtttgtttta ttacggagtt gacaaaatct ataataaacg taaattcaat atttacttta 1867681 aaatgggtaa taaaagattg ggcgaacttg tcgatgaaca tcagcccgat attattatta 1867741 atacatttcc gatgatcgtc gtgccggaat acagacgccg aactggaaga gtcattccta 1867801 ccttcaacgt tatgactgat ttttgtcttc ataaaatttg ggttcacgaa aacgtggata 1867861 aatattatgt ggcgacagat tacgtgaagg aaaaactgct ggagatcggc actcatccaa 1867921 gcaatgtaaa aatcacagga attccaatca ggccgcaatt tgaagaatcc atgcctgttg 1867981 gcccgatata taaaaagtac aatctttcac caaacaaaaa agtgcttctg atcatggcag 1868041 gtgctcacgg tgtattaaag aacgtaaaag agctgtgcga aaaccttgtc aaggatgacc 1868101 aagtgcaagt agttgtcgtg tgcgggaaaa atacggcttt aaaagaatct ttgagtgcgc 1868161 ttgaagcgga aaatggtgac aaattaaaag ttctgggcta tgtggagcgc attgatgagc 1868221 tatttcggat cacagattgc atgattacca agcccggcgg cattactttg acagaagcca 1868281 cagccattgg agtgcctgtc attctgtaca aacccgtgcc tggccaggaa aaagaaaatg 1868341 caaacttctt tgaagaccgc ggagctgcca tcgttgtgaa ccgtcatgaa gagattctcg 1868401 agtcagtcac ttcccttctt gcagatgaag ataccttgca tcgcatgaag aaaaacatta 1868461 aggaccttca tttagcaaac tcctctgaag tgattttaga ggatatcctg aaggaatcag 1868521 aaatgatgac cgccaaacaa aaagccaaag tgctatcgta atggcgtact tgagagcata 1868581 cgaaaatcgt gtgctctttt tatttatatt cagccatcaa taaaagcggt tacatttttt 1868641 tatggaactt gcccttcttt tgaaaaataa gccgtttcgc aacttgacgg gtgctcccag 1868701 atggtgtata gttgaaccat catttaacaa tgaatcaaag ttagatgatg acaaaatttt 1868761 ttttagcaca tgggtgctac agtactagga ggaattaagc aatatgcaaa acggtaaagt 1868821 aaaatggttc aacaacgaaa aaggattcgg cttcattgaa gttgaaggcg gagacgatgt 1868881 atttgttcac ttcacagcta tcgaaggaga tggatacaaa tcattagaag aaggacaaga 1868941 agtttctttt gaaattgtcg aaggtaatcg tggacctcaa gcttctaatg ttgtaaaact 1869001 ctaaactcaa tacatgatga tgagatgaca aatagaggag aggcattcgc ctctcctatt 1869061 tgattttcat ctggatttca atcgccaaaa tgttttgttt acacctctgt tcaatctctt 1869121 caacatactt ttccattgat ggttttcctt ttttcgcgat atcggccagt tcttctaaat 1869181 cactgtatat ttctataaat gttttgtgaa ggatcaactt caagtcttta tcatccatag 1869241 ctgcgttccc cttctctatc aagatacctc aaatagtaaa acggtcctat ttattctggt 1869301 tcaatagtta tatcggctta tttttatttt cttttctatt ttggtacata aatttcaaaa 1869361 aaactctgca aaataatggc ggaggtgttt tttgtgactt cagaatttca taatgaggat 1869421 cagaccggct ttacggataa gcggcagctg gaactagcgg tggaaacagc gcagaaaaca 1869481 acaggagccg cgacgagagg ccaaagcaaa acattagtcg actctgcata ccaagccatt 1869541 gaggatgcta gagaactgtc acaatctgaa gagctggcag ctctcgatga tcctgaattt 1869601 gtaaagcagc aacagcagct gctagatgac agcgagcatc agctggatga attcaaagaa 1869661 taaaaaccgc agcttctgcg gtttttattt ttagtgattg gttaagacat ctccgtattg 1869721 tttcaacttt tcaccaaccg tacatttatt gatacaaaat gaatgcgcat aagttttgcc 1869781 aaattctttg cgaaactgct tcttaataaa acagtccttg caatattcat cgtgcagttc 1869841 tgtcagttct ttaaagatca ttttcttatc caatatcgtc atctccgtta cggtctaatt 1869901 tcgtgtggct ttctacgaat tgatgggata gaattttttt agcgaggccg tcagcttcct 1869961 gattgtcttt tcgttgtatt gtttcgtagg ttggagtaag cttcagcgat tcaaggagtg 1870021 cttctatttt gtccagccat tcattatgag atggatcata acaaggccag ctgccgtcaa 1870081 gctgattcag cacaacaagc gagtcccctt tgattgtaat tgaatttctg cttgccccaa 1870141 gctctcttac ttctcttatt gcttcataaa gcgctgcgta ttcagcttca ttattggttt 1870201 tcagccggaa gcttttattt tttctcaagc gatgccgggt tcctcccaat gaataataga 1870261 tgacgatccc gagaccggcc agttcgctct ctttatcgaa actgccgtca aaataaacag 1870321 taatgtcatc aggctcttga gcaagctcct ctgtcagctt ttccaattcc ttcagcgtcc 1870381 agctgccgcc tttctcgtct tcgaactcta gctccttcat gtatggaaaa cggccaagtt 1870441 ctctggcgaa cgtacgtgcc tgctgtgctg tcagccagtc ttcgctaaaa aatgagacgg 1870501 atcccgttcc ttttgcttct attttcaaat gcggtctgag cttcattaca atcaccttac 1870561 cattcattag ttgccgggct tatgctataa tcaaaccaat cttaccccgg aaaggaagct 1870621 ttttcatctt gtttaataat tcgttttgga tcttttttgc gatcattcat tttatcattg 1870681 ttcttttatt ttataaagga tttggcaaaa tgggactgtt tgtttggatc ggttttgcga 1870741 cagtctgcgc caacctccaa gtcgtcaaaa cagtcgaact gtttggctta acagcgacac 1870801 tcgggaatgt gatgtatggc acaatctttt ttgcgacaga tgtgctgaat gaaaaatacg 1870861 gaccagctga agccagaaaa gcggtatggc tcggattctc aacgctcctg acgctgacat 1870921 ttgtcatgca gggcgtgctg cttttcgaac cggcttccag cgacatatca caaacagcgc 1870981 tggaaacgat cttcggattc cttccgcgag ttgcgttagg aagtctgctt gcctttatct 1871041 tcagccaaac gctggatgtt tatgtatatt cggcaattag aaggatattt ccttctgatc 1871101 ggcttttatg gctcagaaac ggcggcagta cagcagtcag ccagttgttt gatacattca 1871161 tattcactgc agtcgccttt ctcggcattt atccggcaga cgtgtggctt catattttta 1871221 tttctacata tttgattaag tttgcggtat ctttaatttc attgccttat gcctatgcag 1871281 ccaaaaaaat gatacctaat gatgaaagga gttcataatg cctacagaaa tatatgtaga 1871341 cggcgcaagc gccggtaatc cagggccttc cggtatcggc atttttatca aacatgaggg 1871401 aaaagcagaa tctttctcta ttccaatcgg agtgcataca aaccaggaag cggaatttct 1871461 tgcattaatt gaagggatga agctatgtgc aacgcgcggg tatcaatcag tttcctttcg 1871521 aaccgattca gatattgtgg aacgcgccac tgagcttgaa atggttaaaa atataacgtt 1871581 tcaaccgttt gtagaagaga tcatccgatt aaaagcggca ttccctcttt ttttcatcaa 1871641 atggataccg ggcaagcaaa accaaaaagc cgatcttctg gcaaaagaag cgattcggct 1871701 gaatgaaaag aattaaatct tgatcattgg ttcatcctaa tggcgaggtg aactaacatg 1871761 aaaaagaaag ataaaggccg gctgaccggc ggtgttactc cgcaaggcga cctggaaggc 1871821 aatacacata atgaccctaa aacagagctt gaggagagag caaaaaaaag caatacaaaa 1871881 cgctagagag gatctaaacg atctctctag cgttcagctt ttcaagcata cgctcaattc 1871941 ctttaatttg gtggcggcga agcatgtcag ccgcctgctc catttgcaaa gtaaataaag 1872001 cgtctttcag tgtgcaggcc agcggcactg agcaatggat ttccgcaagc ttcctcgaca 1872061 tctccaaatc gcttaaacct tgctgaattt ttccctgctg tccttttgga agaagagaaa 1872121 gattttccaa taaacggtca atcgtttcgt attcacgaat cagtttgtag gctgtttttt 1872181 ctccaatgcc tttgactccg ggatagttat cactggaatc acccataagc gctttaatat 1872241 caatcaaagc cttcggcatt acgcctgttt cttcataaaa agtctctttt gtatagactt 1872301 tataatttcc gattcctttt tgaagcaaag caacgcttac tttatccgtt aacagctgaa 1872361 gtaaatctct gtcccctgtt accaccgtaa tgtccgcttc attcgcaaat aaatcggcaa 1872421 gagtaccgat acagtcatcc gcttcatagc cggcaaagcc aatattcatg attccaagct 1872481 ctgcggctgc ttcctttgcc aaatcaaact gcggaatcag ctccacaggc ggcgcgctgc 1872541 ggttggcctt ataatcttgg aacaagtcat ttcggtacgt tttgctcccc atgtcccagc 1872601 agcagacgac gtgtgtcggc tggaatgttt ccacagctgt aatcaaatgc tttaaaaagc 1872661 cgttgacgcc gttcgtcggc accccgctgt catttatcat aaagttgcga tgtacggccg 1872721 tggcaaaaaa ggcccggaat aaaagagcca tgccgtcaac cagcaatagt ttattattat 1872781 tcatcaaata actccctttt ctttcattcc ttctatttta tcataaagca gcccaaaaat 1872841 aaaaaacagt atctctttaa ttagagatac tgtttgaata tttatcaatc gttgtgtctt 1872901 ttgttgctgg cgatcagctt ttcagcttcg cgtcctgcgt aagagtcaaa atgggtttga 1872961 aatccgtttt tctttttggc gttgttattc gcctgtgcat ttctgtttcc gagctttgtt 1873021 ctgcccaaca tgaatccccc cttacgtcgg atgcatatag tatatgcttc cggcaggagg 1873081 ttcactcgcg acaggatcat ccagcttaca tgcggcttac gtattctctg accatttctt 1873141 ttgatacaag ccgtcttgtc gggacgatgc cttttttagc gagctgattc atttgctcgg 1873201 taatttcatt aattgcatct gtagtataag gctcatcgtt tctgcattta gcaacagctt 1873261 cttcaatcgc caattcacgc atattttcaa gacgcataaa tgctttgata tgctcgtgct 1873321 gttttgatga atgtgctgaa attgctttat gtacctctga cattaatcgt tcatctcgct 1873381 tttttctatt tagtctatca tgacttgaaa tacaagccaa ctgaatttta catttttatt 1873441 gtattgtctg aatttttcca ggagatgcac gcctgatacg ccatttcaat ctctttcgca 1873501 tgttcccctt ccgcatatcc tcttaaatat gtctcttttt gatccgttat ttgcgcgatt 1873561 gctttttcac ccatatcttc ctgtaagcgt ctgaggtgag cagtgtaatg agatatcagg 1873621 ctttcttctt cattttttat ccatgcctct gtgattttcg taagtttcat ccgtacagct 1873681 tcgataaagg tcgcttttcc tttctgctca aaaaactgct tcggtgattt gatctctttt 1873741 agttcctgct caaaagcacg ttcttctatt tccggttcaa cttccttcaa ctgtatgccg 1873801 ttcgaatgct gatcacccgc ataaacggaa aaataaccgt cctcgtttaa tgttttttga 1873861 aaatgatcca gccattcttc attgatatgc cgttcgatga aaccgctcat gcgaacatca 1873921 agcgttttga tttcctgaat atattcaaat agatattcat gtaaggctgt tgtcatcgct 1873981 ttactgacgt tctttttcca atccccgttt tgcagcccgg gatgaaatgc cgattttaat 1874041 aaatcatttg caaaatatga taatcgctgt gcaatgtgat atagctgctc tcttgtatct 1874101 ttttttactt tttcaatgat ggtttttgag ttccgccgtt tctcgatatc ggccgctgtc 1874161 cgctcaaatg acagcataag gcactgtttc tgcgcttcct tctcttctcg ggactgatgc 1874221 tgggattggt gaagctgaaa aacagtttcg catagtttgt ctgcctccga actgagctgc 1874281 gctgctgacg ctttttttac atccacttcg ataaaccggt ctaagtgttt tcttactttc 1874341 gagaactgat tataaaatga ctccggtttt cccaccagtt cctccttact tgatacggta 1874401 aagagctgcg gctcataaac cccttctttt acaagctctg cgctgacata atcggtcact 1874461 gtttcgagct ctgttttatc ttttgcaagg tctgcagcat taataataaa aaacatttta 1874521 tccatgctga gcgattcttt cacaagtcca agctttcgca aaaatgaacg gtctcctttt 1874581 gaaaaagagt gctgataata agtcatataa aaaaatgcat cagcatcttt gatatattgg 1874641 aatgccagtt ctgtatgccg tttattcatg ctgctcgcgc cgggtgtatc aacgatcgta 1874701 atcccttttt cagtgagcgg gcatgtatag tagaccgtta cctctttcac agcacaggcc 1874761 gttgtttcct ctgctacata cggctttaat tcagagagcg gaatcgttaa tttcttctgt 1874821 tcctgtatat actgctgata cttctcgtat gcaagcagga aattgctgat caatttcacg 1874881 tgttcttcct gcagcctgtt ttttttgact gccttttccc acttctctgt gaaggaacgg 1874941 cctgccggct cctttggtat tccggtgagc tgcaaaattt cagccgttaa gtcatcctct 1875001 gtcttaaaca ctacattcgc tgttttgttt aagttgccat tgattggctt tgtgatcttg 1875061 ttaattgtcg ctgtggttgg cgttggtgag gatggcagca ctctttcgcc gacaagcgca 1875121 ttggcaaatg atgatttccc cgagctaaag cctccaaaaa gagcgagtgt aaatttccgt 1875181 tcctcaagcc ttttcaccct ttcacgaaac gctgaagttt gctttaacaa catgctgcat 1875241 tcgcctaaaa tgtcagacaa agtgtaaaag cgtttgattt ggtcttgaag cggcatttct 1875301 tgttccattt tgatttctga tttcggcatc ggctgcgccg tcagctggct tcggccttgt 1875361 ttctgctctg gagccgccac tcttgttttc ttcgatttaa accattctgt gtctatatgc 1875421 attgggcatg cggactcttc ttcccaaatg gcccacaggc gatcggtttt ctctcgggca 1875481 ttattctcta aacgtgcctg ttcttgaaga aagacaagtt tttctgattc ttggacgagc 1875541 cggtcgttaa ttgtttgcac atctttggaa acacgctctt tcaccatagc ggagagcacc 1875601 tttatgatgt ctgcggcttc tcttttcgcc tctttccgga tgagctctgc caagtctttt 1875661 gtatattgca atacatattc agaggaaaag gctgcaccat gcttgaccgc gtgttcaatg 1875721 atgcttatat caagcggtgt gcgataggcc tgaatcagct tttcactttc agcggtatag 1875781 acatcaaata ccttggcgag tttatgaagc gtgtctatca tatgccaatc cgcttcggcc 1875841 tctgttcgtt ttgccacatc agagaaaaaa gcattccgcc ttttatctct ttcctgtgca 1875901 gttttcgctt tagaaaagaa aaagccggtt ttaaaggaag gctcttgtga ttctaaaaat 1875961 gcagccgcca attcacgcat ttcaaaaggc gtcaggttgg cgttttttaa aatacgattg 1876021 atttcttcct gcatcctctt ctctgcctca gtcatttgtt tttcggcctc atccaattga 1876081 tcacgcagcg attggaccag tccagtatgg atattaagct gttcagcgaa actcggagcg 1876141 cctgtttcgt ctttcttcag catttccgta tgttccttta gcagattacg gactttttgt 1876201 tcggttaaag cctgcatatt gctttttgat tgctgttcta ttctgcttaa ctcttctctc 1876261 agggccccca tctgattgaa cgggtgatcc ggttctgtta ctgatgtaaa atagagcgct 1876321 tcccttgaaa tcccttcatt gcaaagcatc tcctctacct gcgcttgata gtctccaaat 1876381 ttcgtctccg tctcatcatg gcggtcaatt tgattgacga taaaatacac attcggaatg 1876441 ctttctttta ttgatctgag aaactttaca ttttcctcag cgtgcacgtg attatagtga 1876501 acgacgtaaa acagcgcatc cgcttggtga agaatagaag cagccgatag aaaatgcgca 1876561 tcatctgttg aatctatccc tggagtatca atatacgcaa ccccggaatc gatctcagta 1876621 tacctgtcaa aaatttcgac gctttcaatc tgttccccgt ctttacaata ttgctgcacc 1876681 ttgtctttct ggtaagtccc ttccagctca gcacacgctc cgtctgttgt atgaagccga 1876741 actcgctttt ccccgtttct gatcacaaca aggttagcgc ttgtcggaat cgggcttgtc 1876801 ggcaaaatat tctccattaa caggcagttc agcagtgacg atttccccgc tgaataatgc 1876861 ccggtaaacg cgatataaac ctcttcatca gccgcttttt tcatgaccgc agccagttta 1876921 gcagcccttt gttcatcttg attctcaata aattgcttat aaagttcccc ggttttatgc 1876981 aaaagctctt ttctgttttg atctgtcata agtctgaacc cctttgtgcc gtttcaattg 1877041 tgaacctttt tcgaaagatc tgaattcatt cccttttcat tttacacaag aataaaccaa 1877101 atttctttag gagaatagaa aaaagccgcc attacggcag cttctataaa agaaaatctg 1877161 caacttttac aagttccaga ttcatcaaac agatttatta gagattcctt ttaatacaaa 1877221 accaattaat acactatatg tacaaaccgc tccaagcaaa aacagcattg tcatttgctt 1877281 caccatcctg attgagaatc tttttcaaac ccattttaac atggttgaga atgattttca 1877341 atcgctattt tacgctgtat tcctgtaatg ctttgtcttc tgcgcgaatt ctgacgctta 1877401 acaacacggc attgaaaatg gaaaacagac acatggtgac gtatgcttga taaagcagcg 1877461 gaatcagcaa aatttcgagg ataacaacgg catagtttgg atgtttcatc catttatatg 1877521 gacctttttt tacaagctct acacctggaa caacaaggat tttcgtattc caatatgctc 1877581 ctaaggaaca aagcgcccaa taccgtacga tctgtacgct taaaatcact gcagcgatac 1877641 cgagccacca gctggacggc tgtttattca tcagcagcac ctcggcaatt aaggacagga 1877701 aaaaaaggat atgcatcgta atgatatacg gatagtggct ctcgccaaat tcaattgctc 1877761 cttgcttctt taccttttgt tcgttttgcc tggccactgc catttctgct gctctttgaa 1877821 caatgagaat ggcgatcaac aaccaaaaca tgagtcaggc ccccttttcc cagctgaata 1877881 atagcaactc tgatgagaaa cccggcccta atgcgccaat cagtcctcgt tcagcttcct 1877941 ttttatgtcc gttctgcaga tggtctttga tcacatacaa gattgtggct gaagacatat 1878001 ttccgtgctt ttgcaaaatg ctttgcgcag atgaaagctt ttctgacgac agcccgagac 1878061 ttttgatgta tgcatcgatc actttttttc cgcctggatg cgccaaaaaa acactgatat 1878121 catggaatga cagcttatgt ttgtccaaaa aaatctgtac atttgttttg agccattttt 1878181 ccaccaaggt cggaatgtct cgtgagaaaa tgactttgaa tccttgatcg gtaaagtccc 1878241 agcccatgac atcttctgat tgtttcatca aaacagattg ggcgtccatt atcttcggcg 1878301 caagcttcag ctttgacacc ctgcggtccg ccttctctcc gcataataaa gctgcggcaa 1878361 tgccgtcacc aaaaagcgag gtgccgatca gattgctttt tgttttatct tccggctgga 1878421 atgtcaggct gcacagctcg gcagaaatga caagcacaaa agcctcagga tacgctttgc 1878481 agtattcggc tgcacgcgca agtccgctgg ctcctcctgc acagccaagc ccccaaatcg 1878541 gaatccgctt cgtatatgga gaaaacggaa gttcattcat aagccgcgcc tcgatactcg 1878601 gtgtggaaag acctgtactg gagacgaaaa aaacagcttc cactttctca taaggaatgg 1878661 cttcttgaaa aaattccgga tgagagaggc actcacgaac agccgctctg ctgtgtttaa 1878721 gtgtttcttc tatgtatatt tgattttttt cttcaaagct gtgcccctct ttataccatt 1878781 caatcggctt aacaaactgt ctcgaatgga tttgcccgtt tttaaaggag gataacagcc 1878841 tgtcaatatc cttaaaagaa tgctgaaaca tatagcgggc gaactcggcc gctttctctt 1878901 ggtttacatt atacgcagga agacttgttc caatggataa aataaacgcc atgcgatcac 1878961 ctctttgcat acattgtgcc gcaacaatct tttttatatg caaaaaaaac tccgccgcgg 1879021 cggagttaga ctgctgtttt ttgttcagcg aggtcagctt cttgttctat ttttttagct 1879081 ttagaaaaaa cgttatatac aatatttaag acgactgcag taaagctgcc cgccacaatg 1879141 ccattcgttg taagcagcgt taaggcactc ggaagctgtt tgaaaatatc cggcacaacg 1879201 gtcacaccga gccccaatcc cactgagcaa gcaacaatca gcagattttc ctgtttcgca 1879261 aaatcaatgc ggctgagcat tttaattccg taagcaatca ccattccaaa catcgccacc 1879321 attgcaccgc ccaaaacagc ggatggaata atagtcgtga aagcagcgat ctttggaaac 1879381 agcccaaatg ccattaggat cacacctgtg accacaatga cggcattttt tttgatccct 1879441 gtgagctgaa caagcccgac attttgagag aatgccgtgt aaggaaaagc gttaaaaata 1879501 ccgcccagaa gcacagccag tccttcagct cgatagcctt tagacaaatc tatctctgtc 1879561 aaacggcggt ttgtcaggtc acctaaagca aagtaaacac cagttgactc cacaaggctg 1879621 acaattgcaa cgatggacat cgtaatgata ggcgctgcgt gaaaagacgg cgctccgaag 1879681 taaaatggct gaatcatttg aacaactgcc gcgtccgaaa cattatcaaa ttgaactttt 1879741 cccataaaat atgcgatgaa ggtgccaatc aaaataccga tcaaaatcga gacggacttg 1879801 ataaagcctt ttgtaaaacg gtatagaagc acaatgatac tcaacacggt aaaagcaagt 1879861 gcaagattgg agagatctcc gaaatctgca cttccttctc cgccggccat gttattcatg 1879921 gcaaccggca tcagtgtaat accgataatc gtaacaacag agcctgtcac gaccggcgga 1879981 aaaaacgata cgagctttcc aaagaaaaat gaaataagaa tgacaagaat gcctgaagcg 1880041 ataatgctgc cgtaaactgt tgaaacccca tattcagatc caatcgctat catcggcgat 1880101 acagctgtaa aggtacagcc aagcactacc ggaagcccga tcccaaaaaa tcggttgctc 1880161 cacacttgca gaagtgtagc cacaccgcac ataaaaatat caatcgatac taagtaagtc 1880221 agctgctcga cagtcagtcc cattgctttt ccgacaatca gaggaacgac aatggcgccg 1880281 gcatacatgg caagaacatg ctgaatccct aaagacagcg ttttgccgaa tccatttctc 1880341 atgaatgaac ctcctgtacg aaggacactt ttccttcttc taaagactga attcttgcca 1880401 aagattccac tcggtagccc agttttacaa gttcatctct tcccggctga aatgactttt 1880461 caataacaat gccgattccc gcaatagaag ctcccgcttg cttcacaatc gacacaagcc 1880521 cgtgcgctgc ctgtccattt gccaaaaaat catcgataat cagcacatga tcctgatccg 1880581 acaggtgggt cccagacact gcgatttggc tttctgtttg cttcgtaaag gaataaacag 1880641 acgctgtcag caagttgtcg gtgagtgtta acgatttatg ctttctcgcg aagacaactg 1880701 gcacacccag cttcaagccc gtcattacag cgggagcgat acctgatgat tcgattgtca 1880761 caattttggt aataccgtct tttgcaaacc tagacgcaaa ttcatcacca attctctgca 1880821 taagcagcgg atcaatttgg tgattcaaaa aagaatccac tttcaatacc tgatcagata 1880881 atacgacgcc ttcttcctct attttccgtt tcagtgcttc catcctgtct acctccgtta 1880941 tgagaataaa aaaagcattg cccgctcaaa taaagagcaa gcaatgctga tatcacaaaa 1881001 aaccgtacac gtgcggttcc attgctcacc catagtcgga catttacggt gcccggtaga 1881061 aacttgcgtg ccatatccac gcgattatat gagtgttcct attatattgt aataaattat 1881121 atcaagattc taatctcttg cataggctga aaataaaaat tcccgaactt taattttgtt 1881181 tttttagata tcattcgtat ttcaagggga ttcgatataa aagagtctga cgaccgcgcc 1881241 gccaggcttt tgattataac agatagagat ttgaatattt gtttgataaa taatcaatta 1881301 aatagcgaac attcagctct tctcctgttg catctttaat aatgtctaac ggctttttcc 1881361 gttttccgtg aatgtgcacc ttttccgtca gccattgctt tatcggatgg aactctcctc 1881421 tttccaagag agcgtcaaat tcagggagat cctcaagcat tttttgtttc agctgagccg 1881481 catacatgta gccgagcgca taggatggga agtagccgaa atctccacct gcccaatgga 1881541 cgtcctgtaa aatcccctct gcgtcggtct gcggtgtaat ccctaaataa tcctggtatt 1881601 tttgattcca aagcgacggc agatcttcca cagacacttc attgctgaaa atcgcttttt 1881661 caatttcata acggatgatg atatgaagag gatacgtcaa ttcatccgct tcgaccctga 1881721 taaatgaagg ttttgattca ttgattgccc ggacaaaatc atccagggag atgtccttga 1881781 actgtacagg tgatgcctct tgaatcttct tatagtacgg agtccaaaaa tgcttgttgc 1881841 ggccgataaa attctcgtaa aataatgatt gcgattcatg aattcccatc gatgcgccgt 1881901 ctgacaagtt cgtgccactg agtgcttcat caatattttg ctcgtaaatc gcgtgcccgc 1881961 actcatgaat ggtcccaaag atcgccgtcc ggaaatcttt ttcatcatat ctcgtcgtga 1882021 cccgaacgtc tccccgattc agcgtagttg caaacggatg aacggtttca tcaagtcttc 1882081 cgccatcaaa atcgtagcca agctcctgta aaaaatacag actgagctct ttttgctttt 1882141 ctttcgggaa cgcttttgta ataaagcttg tatctggttt atttccggaa gctgtcacct 1882201 gtttaacaag agggataatc gcttccttca gctcagcaaa caactgatca agcaccttta 1882261 ccgtgacgcc gggctcaaac aaatcaagca atgcatcata aggatgctct tgatatcccc 1882321 aatacgtaat aaaacgttta ttgaattcaa tcagctgttc taaataagga gaaaacaagc 1882381 tgaaatcaga ttttcctttc gcttcctccc acgctgtttc tgcctttgaa cacagaatca 1882441 cgtattcttt gtattcagcc tcagggattt tcttattctc ttcatactct tttttcgcca 1882501 gttccactgc ttttttcgta tcttccgaca agtcatcaaa tcgttcatac aggacatcga 1882561 taagctcctt cattcgatct gatgtttgga tattgaatat atctgttgaa agctggccga 1882621 tactttcggc acgatcctct gagccatttt tcggcgcgcc tgttctggag tcccagtgca 1882681 ttaacgcaac tgcttcgctg taatgtgaga ttctttttaa aagatcaaaa aattcttttt 1882741 catatgtatg tatctccata tccattccct ccctattcta gccgttccat tacaggctaa 1882801 tggaaggggg tatgaaagtc aaattgtttg tataaaaggc tgccggtatg ttttgtggca 1882861 gcctttttat tcagttgatc gtcatttgat tttttggcgg aggtgttctc cgctttttct 1882921 gcttgatttt tttatctacc cacactgttg ccagcggggt taagagcgag gtgacaataa 1882981 cgcttgtcgc gataattgca gttgccgact cagcaactgg cgcaaatgag gcattcgctt 1883041 ccgctaatgc atatggcacg gctacagccg cccctgccgt agaagaagcg gccactcccg 1883101 cgacaccatc tccccgcgca ataaaacgat caagcaaaaa caaagaactg cccgataaaa 1883161 tgacgacaga aactccgata aaaatgccga gcagccctga ttggatcagc attccaaaat 1883221 tcaaggtatt gccgagcgaa aaggcgaaaa atggaatgat cgccggcaca accttgctga 1883281 ataagtctct gagatcatga tccagatttc caagtataca tccaagtaaa aacgggatga 1883341 ctgtcgctgc cagcgtttcc catgggaatg cggcaagtcc cgtcacacca aacgtcacca 1883401 tggtcataaa aggaccagat tctgtactga taaaggcgaa agcgcccgca tcctcttttc 1883461 ttcccatgtg attcatgagc gccaaataca gtccgccgtt cgtttcattc attaccgcga 1883521 caattgctaa aacagaaagg cctgcaaaaa agccggattg tatgccatcg tcaggtataa 1883581 attgcgctgc gatcacgccg agcagcgccg caaatccgat cttccccaat aataacgtga 1883641 ttccttttct tgcgatatag cctgaagaac gaaaatcaat cgttgctcct acgcaaaaga 1883701 taaaaacacc cagtatcggc agcgttccgg taatcaaagc acccgtaaac cctccaaaga 1883761 actccgctgt tccaggcgca aacgtgttga gcgccgctcc aagaaatagc ggaataatca 1883821 tcattccgcc aggtacccgt tcaattgtcg ccttgatttt catattgtgg attctcccat 1883881 cctccggtta tgaaaaaaca attccactta cacttggaaa acagcctgca aatcctcttt 1883941 tgaacagctg cccaactggc tgccgactcc gacggcgcca gctccggctc taagccaatc 1884001 aggcacttca gacggatgta tcccgcctgt cggaataaag gtcacctgcg ggaaaggacc 1884061 cgctaaattt ttcataaacg gaatgccaaa cacaccgctt gggaacagct ttaatgtcgt 1884121 aaaaccgaat gtcagcgctt ccataatttc gctcggagtc aagacgccgg ggatataatg 1884181 tgtctttaca aaagatagat gttcagcaag atcagctgaa aaacccggac tgacaataaa 1884241 ctgcgcgcca gccttagcag cttccccagc ttgctgcgcg ctgatgaccg tacccgcgcc 1884301 aattaaaata tcttccctat tacggaagga ttcgataata tctgatgccc cgggggtcgt 1884361 atacgtcact tcaactgcac gaatcccttt atctaataaa ctctcaatct gctgacaggc 1884421 ctcctgctta tcctttgaac gaatgactgc aatcagcttt gcttctttca gacggttttc 1884481 aacgactttg gactccatat taataatccc ctttcttttg gtgaaccgtt ctttgagcag 1884541 ataaaaaaga agctaatttc tccctggtcg gcaaaccgtc catatccccc ggtgcctgca 1884601 cttgcaaagc gccaatcgca tttccccttt gcaccgcatc cttgtacgac aaaccgtcta 1884661 ggataccgct gattacaccg actgcaaatc cgtctccggc gccgaccgta tcaaccaccc 1884721 ggtcgacccg gcagccttct agaaatcctt cacttgtccc cgttttaaag taagcgcctt 1884781 cttttccaag tttaatagca acaaagctgg cacctttttt caaataatag tcggcaatgc 1884841 cttcaggtgt tttttctccg gtcaatagct ctccctctgc gatacccggg aaaaaccagt 1884901 ctgcaagccc agccagatca ttgattgtgt gtaccattgt tgcttgatca ggccaaagcg 1884961 aaggtcttac attagggtcg aatgaaatgg tcttccctgc gtttctcatg tcgttcatga 1885021 catgatacgt gaagtctttc atctcggctg ataaagcagg cggaatacct gtcacatgca 1885081 aatggcctgc gcattgaaaa taatctctcg gatattcagc tgtagttaat gtgcttgcag 1885141 ctgagttttt cctatagtag gtaacttgcg ggtcgccttc tttcactttt gacttcagca 1885201 gcagcccggt gggattttcg tcctgcgagc ggatcacgcg ggacacatcc actccctctt 1885261 ttttaagctc ttgtaaaata aacgttccga gctgatcatt gccgaccttg ctcatccatc 1885321 ccattcgaaa tccgagtctg gcaaggccgc aggcgacatt gctttctgct ccggcaagcc 1885381 ctttagaaaa agtggatact tcatgaaggc ctccatactc atttgcataa aacatggcca 1885441 ttgattcccc gaatgtcacc gcatcaagct tcatctcttc ccaacctcct cttagttgag 1885501 ggcacctagg attaaagtga ctttctcatg atgacttttg cctctaattc aatggtttga 1885561 ggcgctcctt tgtcaccttc aatccttttt aatacacgtt ccatcgccgt cctgcccata 1885621 tcatgtgacg gctgggcgat cgttgtaatg cctggaccga tcagtttgta ccactccgta 1885681 tcatcgaatc ctgcaatccc tatatcttga gggatgcgca ggccaagctc ttccatacag 1885741 ctgatgattt tcagcataat caagccattc aaagccagaa tcgctttttt ttgctccggc 1885801 atttccttgt gaaaagaacg aagctccgcc ttaagctgct ccttgtcctt tacgtcaatt 1885861 tcatgcaatc tgacaagccc gttcacattt tgaaccgaag ccatttcctg atacacagct 1885921 gctctttctg cacgagggct gatagaggaa atcggttcgg taaacagcgc gacatcagta 1885981 taccctttgc tgtacacctt ctgaagaatc tcttttgtga tccatctgtt gtcagtcgtt 1886041 acggtatcca gtttcagatc cggcagtttc cggtcaatta agattgttgg aatttgctgt 1886101 tcagcaaaag cgcggagtac atccttgttt tcccctgttg cgtttaaaat caagccctca 1886161 accgaatggg cttctagctt taagagcatt tcccgctctt tttcaggact gttatctgtg 1886221 ttgcacacca taatgctgta tccatattga tcacaaacct cttcgactcc cctgaaagca 1886281 gcgaccgaaa aaggatttgt aatgtcagcc acaacaaatc cgattaactt gctttttttt 1886341 attttcaaac cttgtgccat tttactcggc cgataattca attctgcgat tgccttttta 1886401 atgtttttca ctttttcagg agaaatcgcg tcaatttttc cgttaatata gcgggaaact 1886461 gtcgatttcg aaactcctgc acattcagct acgtctttga tggttgtatg gcctgttgtt 1886521 ttctttttca ttcaagtgct cctgtatctc atatatttga aaccgatttc aaaaccgtta 1886581 caacaaaaga ataccataat tttaaaattt gggaagagtt tttttaataa tatgtcaatt 1886641 cattattttt tcgttgactc ttttcactat ttatcctaaa attttctttg aaaccgttac 1886701 caaaatattt tcattcaagt gatgctgaaa tcctaaccaa gggggaaata taatggaaaa 1886761 tcgttattct gtacatcctg aacaagtaaa acgctttaca acagaggagc ttcgcagtca 1886821 tttcttaatg gattctttat ttacagaaaa caaacttacg atgtattact cacatgaaga 1886881 ccgggttgtc atcggcggag cggctccagg gcaaagtgaa ctgaagcttg atgcaggtga 1886941 ttttctaaaa acagacttct ttttggaacg gcgtgaaatc gggattatta atgtcggcca 1887001 gcctggtgcc gttagagtcg gcgatgatga atatgtgctt caaacaaagg attttctcta 1887061 tattggaatg ggcaatcagg atgtatcgtt ttcaagcctg aacggggaaa aagcgaagtt 1887121 ttacttcgtc tccgcttgcg cccacaaaag ctatccgaca caaaaagccg ccctatctga 1887181 actgacaccg gaccgccttg gtgatgatgc agcgtctaat gtcagaagtc tgtacaaagt 1887241 cattcatcag gatggcatta aaagctgtca gctgatgatg ggaataacga tgttagatca 1887301 aaacaacaac tggaatacca tgccagcaca cgttcatgac cgtcggatgg aggcttatct 1887361 ttatctggat cttgaaaagg actcaaaggt atttcatttc atgggccagc cggacgaaac 1887421 acgccatctt gttgttggaa atgagcaggc tgtcctttct cccgcttggt ctattcattc 1887481 tggcgcagga acatcaaact atagctttgt gtgggcgatg gctggagaaa attacacatt 1887541 tacggacatg gatctcattc caatggatgg gctgaaataa gatgggttat ctacatgacg 1887601 ccttttcatt aaaaggaaaa acagcgctgg tgacaggccc gggaacaggg atcggtcaag 1887661 gaatagccaa agccctagcc ggggctggcg ctgatattat cggcacatca catacaagca 1887721 gtctgtctga aacacagcag cttgtggaac aggaaggccg gatatttaca tcttttacat 1887781 tggacatgag caagccggaa gcgataaagg attctgcagc tgagctgttt gaaaacaggc 1887841 agatcgacat ccttgtcaat aatgccggca ttattcatcg ggaaaaagcg gaagattttc 1887901 cagaagagaa ctggcagcac gtactgaatg tcaatctaaa cagcctgttt attctgacac 1887961 agcttgctgg caggcacatg ctgaaaagag gtcatggaaa gattattaat attgcctctc 1888021 tcctgtcttt tcaaggcggc atcctcgttc cggcttacac cgcgagcaaa cacgctgttg 1888081 ccggtttgac aaaatcattt gcaaatgagt gggcagcgtc aggtattcag gtcaacgcaa 1888141 tcgccccagg ctatatttct actgcgaata caaagcctat tcgggatgac gaaaagcgaa 1888201 atgaggacat tttaaagaga attcctgccg gccgctgggg ccaagcggat gatatcgggg 1888261 ggactgcagt ctttttggca tcacgtgctt cagattatgt aaatggacat attttagcag 1888321 ttgatggcgg ctggctatcc cgctgacaaa taaaaaagct gacgaacgat cgtcagcttt 1888381 tttccattac atcatgtgcg gttcaacagg caagaccttt ttgacctcat caatgatgcg 1888441 ttcattttct ccgccagcgt aaatgtgaat cgagccgctg tcttgattcg agcgaatcag 1888501 gcgcccgatg ccctgccgta cacgtaacaa catatatggc agatcaactt cttcgaacgg 1888561 atcttttttc gctccgttgc gcttcgctgt aaatacagga tcgtgtggcg ggaacggtaa 1888621 tgaccaaatg gtaacattct tcaatgcgtc accgggaatg tcgagtcctt cccataagtg 1888681 aactgaacaa agtactgttt cttcttcctc ttggaatttc tctactaagc tgctgatttc 1888741 ctcatcacct tcgaagaaaa ttggatacgg cagctcccat gccgccgaca gctctttaaa 1888801 ctcgtttaat tcttcaaaag aagggaaaag caccagcgtt cttcctttgt atcgtttgat 1888861 tgtttcaatc gtttcagccg ttttttgttc agcgtccata tctgtttttg cgtatagatt 1888921 aatactcatt tgctcgtcat aatcataagg ggaatcaaca gttaatgaca aataatcatg 1888981 aatcccaaga ctgtcggcaa tataatcaaa cgaaccgcct tctgacagcg tagcagaaga 1889041 aaagatataa ggaattttct tagaaaacac tttttcgcca agtacttctg ctaccgttct 1889101 cggcatcacg acaaaggttg attctgcttc ctttttctcc agccagctga tcgcatcctt 1889161 ttgatataga gataatgaat acgccatttg ttcaacatat tcttccacta ctgacagttc 1889221 gtattgatca atcgtataca tttcagactc aaatacaagt gcctcaccga ttttatcaag 1889281 taaacggcaa agctcgtccg ccgccttttt gacacgatgg tcatttttta tttctaaacg 1889341 gtgtgaaccg gctacttcct ttgattcttc agaaagaaca tagaaaaatt cgtcgtttgc 1889401 gagaagcgca tcttcaatca attctgcaaa ctcttctctg atgtcatttt gcagcaatcg 1889461 ttctaaaaac aattcaagag tagactgctt cactctatag gttagcgctt tttgcgcagc 1889521 aaactctaac aagtgcccct catcaaatac aactgcacta tgatcaggca agagcggcag 1889581 ctggccctct cgtttgcgtg attcttccgt ccacacatgc tccatataaa aatcatggga 1889641 acaaatgatt aagtccgttg acttgcggta gtaatctctg gaaagtgtca gaccgcatct 1889701 gtgtctcata tcacaagtca gacagtcctg aaacgagtcg tagcttacgt cagaccactc 1889761 ttcattcgat agatttgcgt actgcttacg gtcgccatac ggataaaagc gctgcatcgc 1889821 ctgggactcg tggacaaatg acggtaacga ctcataaaga tccagccatt tatcatcatc 1889881 agaacgctgc attgtttttt caagcttctt caagcataaa tattgctcat gtgattttga 1889941 cagccttgta tcaattttca gatcaagatg ctcagccagc ttagaaatat cgccctcttt 1890001 tttcaccagc tgttcaatta atgtttcatc cgcacaagcg atgatggcag gtttgccgac 1890061 ataccttgca tagctgattg caaaaagaag atataccagc gttttccccg ttcccactcc 1890121 agcttcggcg aacatgactt ttttctcttt aaacgcccgc tccagctgaa aagccataaa 1890181 tacttgctcg tcccgaagat caaacccttt ttcgggaagg atatcgtaaa acacgtcacc 1890241 aatccaattg ttcaattctt cataaaaatt ctttgttttc gttaaagaaa aaggcaaacg 1890301 tgatgttgtc acctagttcc aacccccaac tattcgacat tcagaccacc aataatatca 1890361 ttttccgctg atgaatacaa taaaaaactt ggcaatgcca agttttttgc agtttactta 1890421 cgattgatca catgcgacga taaaaaagga tggtctgttg aataaatatg ttctaccgct 1890481 ttttctaaat cagtttgcgc atgcgaaatc acagacggag acgaatcagt cccgagctcc 1890541 ttcagctcgt ttgctgttgc gtcaagcgcc ctttgaataa gattaaaatg ttcgctgttc 1890601 agcatgagat cacctctgat ggaaataatc atcattgtat gcgaactttt cattttatat 1890661 acatgcttta ccgcatgtta tcaccgaaac atgcacaaac tacacttgat attccgtctc 1890721 cggattatcc gtcttatcaa caatattcta tcagggagtg atgttgacat gagttataga 1890781 aaccgattag atcagcattc tgaactgttt catcacaatt ggacgcggcc taaacgttca 1890841 aagtctcaag taaacggtca cactgaaatg tcccaaacca acattatatt gagaagcaac 1890901 gcgaaagctc accgttggta acgatagaat agggctgaaa gatgaaagaa gacgcatgca 1890961 gagcgtcttc tttttatgcg ttttctgttt tcttgcgctg cggtcttact tttgaccagt 1891021 attgataata atccgtttta ataaacccgt taaagagttt tcgtttcttc gttgcttttc 1891081 tgccatatgc ttcctcaaag ttttcatttg atgtcagcat atacacagac caagtatcaa 1891141 gcggctcgaa cgcctgcccc atttctttgt acatctgctc aacggctttt ttctcgccga 1891201 gacgctctcc atatggcggg ttgccgacaa ttacgccaaa ttccagattt gtggtaaagt 1891261 ctttgacctg catctgtttg aactggatta gatctcccaa tcctgcttcc tctgcatttt 1891321 cttttgcgat ttgaaccatg cggtggtcta tgtcgctagc gaaaattgta agcggctgat 1891381 cataatttgc cttttcttcg acttcaagcc gcgctttgtt ccacagatct ttaccgatcc 1891441 attcccaatc ctctgataca aaatcgcggt tgaatcccgg ggcgatgttt tggccgatta 1891501 gcgccgcttc tatcgcgatt gttccggagc cgcagaaagg atcaacaaac gggcggtcag 1891561 gcgtccaatt ggttaattgc accaaagcgg cagcaagtgt ttctttaatc ggcgcaccgc 1891621 cctgatcgac acggtatcct cgtttgtgaa ggcccgtccc tgatgagtcc agtgtaatca 1891681 aagcctgatc tttcaataaa gatatttcca ctttatactc agcacctgtt tcttcaatcc 1891741 aatcattggc tttgccggac tgcagcttga gcttttcgac aattgctttt ttgacgatcc 1891801 gctgacagtc aggaacgctt gcaagtgttg attttaccga ttttccgatg acagggaatt 1891861 tcccgttttc aggtataaat gagcgccagt taatcgcttt cgttttttca aacagttcat 1891921 caaatgtttt cgctttaaaa gaagcaacct gaacctttat gcggtcggct gttctaagcc 1891981 aaaggttcgc acggcagatg gcaagtgcat caccttcaaa aataactttc ccgttatcaa 1892041 ccttgcattc gtatcctaaa tctcgtactt cctttgcgac aacagcttca atgcccatcg 1892101 gcgccgttgc aattagtgta tacttcttca tcgtatcacc ctgtctttta aaacttttct 1892161 cttttcaaga taaaagctct ccttatacgg gagagcttgt tttcatcatt ttaaatgtaa 1892221 gtggtctaac gttctgtaag ccatgttttg ttccatcgta ctgcaaacgg ctcatcacct 1892281 cgtactcagg cggcaatcat ctatctacag aaagcattct gtccttctct ccgttgaatt 1892341 ccgttaagaa ggttccccta ccaaaatttg ggtttctcgc tcgaggggtt taccgcgttc 1892401 cactctcacc atttctagtg agacttcgtc actgtggcac tttcaaggat actcagccat 1892461 atccgaagac gtaggctttt ttcctgccgt cagcctctaa agactgccct agcttatgac 1892521 ttcgctaggc acgaacacta cgggcatctc agcaccgtgc gagcatggac tttcctctac 1892581 agattcaaga tctgcagcga ttacccgaac gttaagaaca tgaattatta tataacaact 1892641 gattacaatt tacaagcgcc atttttttca agcgtgatca atcataaagc ttgctgccaa 1892701 aaacgtgttt ttctaagtta gacagccgtt ttaaaatatc aaagtttgtt gtgttagatt 1892761 gcacaggctg ttttttgctg gcttcttcaa gctgtttttt cagctgcaga ttttcctgct 1892821 gcagttcttc aatttcttga tggaaggttt cataatcctt aataatcata tctaaaaatt 1892881 tgtcaacgtc ttcttgcttg tagcctctaa cgcctgtttt aaattctttt tccaaaattt 1892941 ctttcgcaga aagctttact ttatcagcaa gcatcttttt cacctcgtat cgtgaatcat 1893001 cacatatatt ttttcagaaa tctgtacggt tgtcaaattt ctctctcatt gttagtagct 1893061 gtcttcctcc actgtcactc tcaagtcatc cattgtaata aagtagatgg gatagccatc 1893121 ctgttcgcgc cttttttccg ctgtcccaag catatactta ggggagcctt ccttttccgg 1893181 gtcatataaa agcagaagcc cgtcggactt atcaatgaag aactgatttt tttgtttgaa 1893241 ttgaagcggg ctttcataag gacggtgagt caggcttgct tcatagtctg cctgagccag 1893301 aactgcttca tactgttctt tattcggttc tttccagttc ttttcctgct cgtaaaatgg 1893361 tgtgatgaca gctaccttta agtcagggta ttcctcctgc aaatcatatg cagcttctgc 1893421 cgcccacagc tcaactccaa gctggcccga aattaaaatc cattctaatc cttcatccaa 1893481 aaaagcaatc agccggtttt taatggcttt ttttatgtaa tacagcgcct tgtcatcctg 1893541 cttaaatatc cccagttcaa acggtttata gcccgttatt gccaatactt tcatcatttc 1893601 acctgcttta aaaaatgggg ctcccgtggg ccccatttgt tgtgctgcat tgtttacacc 1893661 atcaagctgc acgttttcca tactagtagt cgcagcaagg ttttcctgct tgaaaatgct 1893721 gatgcgtagc cgggtcaaca tttgagaaag tgtgtggaaa gtagtgaacg tgctgaaaat 1893781 gctggtggtt tacgtttgtt gtatgctgtg ggtgaatgtg cggcacgata gtcttcgaaa 1893841 acgtatggtg ttcacagcaa tgagtaggat ggacaattgg cgccatcata tgcggtctgc 1893901 agtgatgcat gataaaatcc cctttccata aactttatta caatactaag ttatgaaaaa 1893961 taaggggtac atgttctgat gcaaagacct attttaaaag tgtgcaatta agctgtcttt 1894021 aaagtttgaa aacacaaaag caatcaaaaa taccacaaca aagaacaagt aaaaaacacc 1894081 cttatacata ccaactctcc ctttaaaaat aactaacgtc attttacagg attcgccgct 1894141 attctacaac aaaatcaatg tgaattcagc aaaaaaaatt catggcgaaa caagtcgtct 1894201 tttgcgcttt cccggggaat atttaagagg aatatttcct ctttagccgg gcaattctca 1894261 catgcagttt ttcagtttct ttctctgata agcatgccgc atcgctaagc gattgctctg 1894321 ctacttgcaa tgcttttccg aattcttttt tcttatgctc aaaatatttc gcgagctcta 1894381 ttacagcagc gtatctgcac ttctggtttt gcgagcggga cagcttttcc caaagcggca 1894441 ctgcttcttc caagcggttt tgttttttgt acaggagcga taaatccagc cgtgcactgt 1894501 cctggtcctc aaacgatttt tctataagcc tttccaactg cttgatcgct tggtccgttt 1894561 ctttatgagc cataaaccat ttcgccatag cataggcttc actgtgttct tttggcgcat 1894621 gtgattctga aaggattttt ttagacatat ggatgtacaa tgaaatgagt gataacacat 1894681 ccatttcatt atgatgcagg acacctttta aaagatccgg ctcttgcgcc ttgataaaat 1894741 gaaagtaaag cattggcgcc aagtagcccg gtgtgtcttc tagcctgcgg atgccgagct 1894801 cctctttttc aaccgtgcca agagatacac ggtccatttt gtgtttccac aggcgtctag 1894861 ctccatgcaa aagatcaaag tggccaaact ccggaagctt cggaagtctg tcacggatca 1894921 aggtgtgcct tgttttcacc tgcggccaat caaaggcttt gccgttgtag gtcacaagtg 1894981 atgtaatgtc aacctcgctt aaaaagcttt ggtacaaggc gacttcgttc cccggtttgg 1895041 gcaaaagatg ctgtttgact gtcactcggt cttcatatac tctcgcatgc ccaagcaaaa 1895101 aaatggtatt cccagctcca cccccaagac cggttgtttc tgtatcaaag aaaaagaggt 1895161 tgtttttgtt ataccctttt gctgacaatg tatgcgacag gccgctttga ttccacagtg 1895221 tgatcacttc ctcaagctca gaaaagctgt ataacccatg gcggtgagaa agcggatatt 1895281 ctacttctct gatgaggcaa tattcatctt cgaagatgaa aggcttcatg ccaaaagcct 1895341 cccactcttc taaaaacggg atgtcatcaa agtggttttc ttgtttgcct gcttctattt 1895401 tttgttctcc ttcgtcgagc gccatgtgct ttttcatccg ttggagtttc ccttttaatg 1895461 acatatccgg cctccctcct tacgacattt gatccaacag ctgcaaaatt ctttcctttg 1895521 cttttatccc ttctatttcc gtacctatac aagacggaca gccgtcatga caaggacaat 1895581 gtgtaatcag ttgtttcgcc gcttcattaa tgtctgaaaa acgtttaaag acttcctccg 1895641 ccaaaccgat accgcccgga taatgatcat ataaaaatat ggttggcaat ccggtatggg 1895701 ctgctttaat ttgagaaaca acatgaacat catttcgatc acacatgata tacacaggga 1895761 caatatgctg cagcacattc gagatgccaa gaagcagctg ttccagtgtc ttttccccga 1895821 tgtcttcatc cgctgttttg atttcgagcc aagctgcact tgtatgcagt tcttcttccg 1895881 gcaaatgaat aggtccagac ccaatatttt caaaagtggt catttttatt tttttaaaaa 1895941 tggtcggcag ggcattgaca gtgacgtctc cgtagtgcaa tgacgtacgg cttttttctt 1896001 tcgttttatc gatttctaat accttcagct gaactgccag gtttgcatcc gtataatatt 1896061 cgacatcgac ttttctgaca tacgcctttt tatggtccca atcgagcttc tcaacttgat 1896121 actgaacgcc ttcatgcaaa taaatcgctt catcatgcaa aagcgtcatc gcactaaaac 1896181 ggtccatttc accgataatc cttacatttg caatatccga ctgatcaact ataacgacat 1896241 tttcctggga ggcggaacgc aaactgatgt ttgacgcagg gaacgactca cttgcccaat 1896301 ggtaccgttc gccgttgcgg tgaagaacag cctcttcctg aagatactca agaatatcac 1896361 tgacttccat ggctccaaat tcttcatcag ctctaaaagg aagctcataa gccgcacact 1896421 ttaagtggtc tactaaaata atcaaattct ccggattgat tcttgcagat tccggcgaac 1896481 gattaaagaa atattcagga tgccgcacaa tatattggtc aatcggtgtt gaattggcta 1896541 ccatgataat caaagattca ccgtgtcttc tgccggctcg tcccgcctgc tgccaagcac 1896601 ttgcaacact tccgggatac cccgtcatta cacacacttg cagctggccg atatcaacac 1896661 caagctctaa ggcattcgta ctgaccactc ctaaaatgtc gccttctctc agtcctcttt 1896721 cgatttctct tcgctctttc ggcagatagc ctccccgata gcctctgatt gattttgttc 1896781 caatctcttt tttcacaagc tcctgaatat ggcttaaaat aatttccacc cgaactctgc 1896841 ttctggcaaa aacaatggtc tgcactttgt ttttaaggaa ctctttcgcc agttcattca 1896901 cttctgcggt tgcgctcctt ctaatattca gcggtttgtt cacaattggc ggattgtaaa 1896961 acacaaaatg cttgcgtccg ctcggtgcgc cgttgtcatc gaccagccgc atcggtttgc 1897021 ctgtcagctg ctctcccaat tcctttgggt tggcaatcgt tgcggaagta caaataaaaa 1897081 ctggatcact tccataaaac cggcagatcc gcttcagccg ccggatcaca tttgccacat 1897141 ggctgccgaa cacacctcga tacgtatgaa gctcatcgat gacgatatac ttaaggtttt 1897201 caaacaaact gacccatttc gtatgatgcg gtagaatggc agaatgcagc atatcggggt 1897261 ttgtaatgac aatatgacct gcttttctca ccttttgtct gattgccgga gacgtatccc 1897321 cgtcatatgt aaagctttta atatcaatgc ccatttcatc aataatttca tttagctcgc 1897381 tcttttggtc ttgtgccagc gctttagtcg gaaataaata taacgcccgg tttgtttcat 1897441 cttgggcgat ggactgcagg actgggaggt tgtagcataa cgtttttcct gatgctgttg 1897501 gcgttacggt aacgatgctc tctccttttt gcacatattg aaaagcggaa tattggtgag 1897561 tatatagttc atcaatgccc cttttcgaaa gggccgcttt gattctctcg tctatacttt 1897621 cgggcatagg ccttgttttt gcttcccgag gctcaatttc atgccaattc acaacgtttt 1897681 catttccttt taaatcagaa atgagttcag tcagtgattt ctttttcatt ctttacacct 1897741 ctttgtcaag tacagtttac cgaatatttg tttgcatggc taggtgcaaa ttttatacag 1897801 ttgaataaaa aaagcaaggc atacgccctg cttatttcgc ttttattgta aagagctttg 1897861 attcgccttt acgagcagcc ttttcgcctg ccgataccat tgatcctaca gcctcaccat 1897921 tcattataac gattgggatg actgtgctgc tcgctttttc ttttattaat tccaaatcac 1897981 atgtaatcag cgggtcaccg accttcactt tatccccttc tttaatgtgg gcagtaaatc 1898041 cttctccgtt catattgact gtctccagcc cgacatgaat taacagctca attcccgagc 1898101 gagtccgaat gccaacggcg tgtttggtgt ggaaaatctg aatgacttca ccttcagcgg 1898161 gagaaacgat ttcaccgcta gaaggttcca ccgctattcc ttctcccatc attttctgtg 1898221 aaaaaacagg gtccggtaca tctgacaggt ccattactgt accgtctgcc ggagaataaa 1898281 taacctcttc tgtcaccttt tcctgaattt tgcccattcc gaataatttt ttcagcaatg 1898341 tattttctcc cttctcattc acttcaaccg ttatcccttc attcaccact atttaaccac 1898401 actttcaatt ttgcttcaat ttataacaac atctggcata gacgcataat ctggttaaaa 1898461 aaggcggtgg cgatattgga attccatgat gacaaaaaga acgaactgca aaagaaagaa 1898521 gaaatcataa cggaggcaat cgacactctt tttcaatcct cagcgttcgg caaccttata 1898581 aacggatttc agaacctaat caactcgagt ttaaaggatg tgcagacgac catacatgtc 1898641 agagaaagag atactgggct gtatatcgat attaccattc cggcgacgtt tcgagatggc 1898701 gagatcgtcg ttgatgttaa atcgaggtat ctccatgtaa cactccaaga aaaacagaaa 1898761 caccaaaatg aggctacctt tacaagcatg acaagaacgg ttcagctgcc ttatgaagtt 1898821 cgccaagaag atatggaaac gtcttggaac gagcagacaa tgacactttt ctttccaaaa 1898881 aataagcatg aatgaacgat tcattcatgc ttctatcatt taaaaaagct ggtaaatccc 1898941 tttattaaag atccgacctg attcattgca ctcattactt gacctgtcgt atccatcatt 1899001 ttattaaaat caaattgccc attggctttt ttgaactgcg acataatgct ttgaaattgt 1899061 gaaggctgct gttgattagg ccttgggata ggataagggt tagaaaatac aggcggctgc 1899121 ataggcatag gctggatcgg agcataaggc tgataataat cctgctgtcc ataatgctgc 1899181 tgaggcagtt gttgctctaa ataaccgggt gcagcctgct gataatatcc ttgcatatgc 1899241 tgaggataat aatagcccat ttgccgagga tagcttcgag agctcccgtt cattgcgatt 1899301 cccccctaaa cacaacatat ttctcttcta tatatgtatg aatgacttct attgtttgtg 1899361 tcacaagtga tgattagcat ttgtcaaatt gtgtcgaaag tttaaatttt ttaaaaacag 1899421 aaaaaagtcg aatcattatg gtaccatatt ttcaatacag atgagagggg atgcaccata 1899481 atgaacgtat catacttaag caaacgtttt gcagaaatga agaaatatga aacagactgt 1899541 atgaataaac tgatggactt tgccaagttc ctctatattc aaggacatct cagcataact 1899601 gagtttcgta acagtatgaa ggttctcgaa gcaaatggag cagaaagccc ggcatatgag 1899661 atgaattaac gtccggcccc ctataaaaac gaaaagaaga cagcctttta ccggctgtct 1899721 tctcttgcaa tttcatcctt tactgcgtgc aatgtataaa ggactgactc agtgatgtcc 1899781 ttgaatcgtt ttttatgaat atgatgaaca taagattgaa ggaccaattc caggaaatta 1899841 tcctttacgg cctcaatttg ctctttatgc acatattttg gccggcggac ttttatcaat 1899901 tcaagagcac cctctgccca gcgagcagcc agttcatcat tctcttcaac tgcaggcttt 1899961 atcgtctcaa aaaaatcata agaatgatta ctgttttttc cttcctgata ccgatcagcg 1900021 cctttttcag caacttcaat catttgctcg gtcatttcca gcaaagtttg tgatagcaat 1900081 atctttcacc tcaatgccta tcgtaccaaa tttcactcac aaattcagcc gatgcggtat 1900141 accttctcaa acgcatacct gtgttcaggc gattgataca gctcatttat acaaatatga 1900201 agatctatga tttcttcttc gagcacactt aggcgatcgt tctccgtttc ccgcatctca 1900261 gcctctaatg catttacaga atgattcagg ctttgctcag ctcgcgttaa ttcatcttct 1900321 atatcagaaa gcatacggag aatatctgtc ttgcatacat aaccggacat tcgtgtacct 1900381 ccctttcctt gtctctcccg gttaacattc tttgctctca aggctctttc cttcctcatg 1900441 acaaaactag aagcaaatcg ccaaacaaac aggtattcca cgaaaagctg aagttttcga 1900501 caaaaacacc cgcaaaaatt gtatgatcct cctcattaat gcaaacgata cttgtgagga 1900561 ggtgccgtat gaaaacaaga ccgaaaaaag ccggccagca aaaaaagact gaatcaaagg 1900621 caatcgattc tttagataaa aaattaggcg gcccgaaccg cccttctacg taagaagcaa 1900681 ggaatttcct tgcttcttta ttttttcagc cactgctcca ccgcaaaaag cgcatgaagc 1900741 tggcgctttt tatgtaaata ccagtctgtc aattcaatct gcttcggcaa ttcctcgcgc 1900801 ctaaagaacg ttttctttat ctttccatga aaccaatctg ttttcgttcc gtctaatgag 1900861 tggattaact cagggtagca tgtccttagc ataggagatg ttctttttgt aatcccgatc 1900921 atcttttcca tatcaaaacg ggaacctgtg tgcggcactg tgtgcaaaaa gtgataaaaa 1900981 gaggagaaca attctggctt gaacagcaat tgagacagct gctttcccag ccttatcctt 1901041 tcctccgcct ttgaaaagcg tttcactgaa atgccgtaaa aaaacccatt tgaggaagga 1901101 aaaataacgg tgttaaaatg aaaccagtca cttaaataaa aaggaatcgt gtcaaaaaca 1901161 ttctttttaa acgaaggatt ttgtataata ggtgtttgga tagtgttttg ttcatttata 1901221 atgagggcat acattagccg ctccgtattt cgctcatgcc aaaaacgggt ccattcttcc 1901281 gacataaatt gtgagacgcc aaacacatgc agcagatgaa acagcggttt cccaactctt 1901341 tttgaccagt ggtataaaag aagctgcgga taggcatccg aaaaaataag ccagttcgct 1901401 ctttcatagg ctaaaaagaa ccatttttgc tgtctctcac ggagtccaag ctgaaacaga 1901461 ctgcctttta agtcagtcat tgaccagccg gcattacgag aaacgaaaga agccaaaagc 1901521 gaccatttga tttccggatg acggtcgtaa aatgctttat aagcatttgt tcttgaaatg 1901581 ttatccgcgt ttttcatttt tgtctgccgc tcaatccggc tcagaagctt tctgatggcc 1901641 tgttgttctt gcacgttcat tcacttccgt catgattagt ttaataagga ggatgagaaa 1901701 gtgattcggt atcctaatgg aaaaacattt cagccgaaac attcggtttc atcccaaaac 1901761 agtcagaaaa gggccccgtc ttacagtaat cgcggaatga ccctcgaaga tgacttaaac 1901821 gaaacgaata agtattatct gacaaaccaa attgccgtta tacacaaaaa gccgacacct 1901881 gttcaaattg taaatgtcca ttatccaaaa agaagtgccg cagtgattaa agaagcttac 1901941 tttaaacaat catcgacaac agactacaat gggatttaca aagggcggta tattgatttt 1902001 gaggcgaaag aaacgaaaaa caagacctct ttccccctgc agaattttca tgaccatcaa 1902061 atcgagcata tgaagcaggt aaaggctcaa gacggtattt gttttgttat tatatccgct 1902121 ttcgaccagg tttatttttt ggaagccgat aagctgtttt atttctggga cagaaaagaa 1902181 aaaaacggca gaaaatcaat tcgaaaagat gagttggaag aaacagctta tccgatttct 1902241 cttggatacg cacccagaat tgattatatt agtattattg aacagcttta tttttcgcca 1902301 tcatctggtg cgaaaggttg attaacgaaa ggttgagatg ttatgtcaga tcaatttaac 1902361 agccgtgaag ctcgacgaaa agcgaacagc aaatcgagtc cttcaccgaa aaaaggcaag 1902421 aaacgaaaaa agggcggatt gtttaaaaag acccttttca ctttactcat tctgtttgtt 1902481 ttaggcgtag tcggcggtgc tgttacattt gccgtcatgg tttctgatgc gccgtccctt 1902541 gatgaaagca aattgaagac gccttattca tcaacgattt atgataaaaa tggaaaagag 1902601 atcgccgaag tcggcgccga aaaacggacc tacgtctcga tagatgaaat tcccgatgtt 1902661 gtaaaagaag cctttatcgc gacagaagac gctcgttttt atgagcacca cgggattgac 1902721 cctgtccgta tcggcggtgc attagttgcc aactttaaag acggcttcgg ggctgaaggc 1902781 ggaagtacga tcacccagca ggtcgtcaaa aactcccttc tttcacatca gaagacgttg 1902841 aaacggaagg tgcaggaagt atggctttcg attcagctgg agcgcaatta ctctaaagat 1902901 gaaattttag aaatgtattt aaaccggatt tatttttctc ctagagcata cggaatcgga 1902961 aaagcggcgg aagaattttt cggcgttact gatttaagca aattgactgt cgaacaggct 1903021 gcgacgcttg caggaatgcc gcagagccca acagcgtaca acccggtcaa aaacccggat 1903081 aaagcggaaa aacgacggaa catcgtactc agtctgatga aaaagcaagg atttatttct 1903141 gattctcaat ataacaaagc gaaaaaagtg gcagtgaaag acgaaggcgt cgtgtcacag 1903201 aaggaatatg aaaaagcaag tacaaacaaa tacagcgcat ttgttgaaga ggttatgaag 1903261 gaaattgatg aaaaatctga tgtcgatcca tctgctgacg gattaaagat ctatacgaca 1903321 ttagatacaa aagcacaaga taaactagat gaattaatgg acggagacac cgtcggattt 1903381 actgaaggca tgcagggcgg tgtgacgctt ctcgatacca aaaacggaga agtccgagcg 1903441 attggtgcgg gacgcaatca gcctgtcgga ggctttaact atgctactca aactaaggca 1903501 cagcctggtt cgaccataaa accgattttg gactacggac cagttattga aaataagaaa 1903561 tggtccacat acgaacaaat tgatgactca gcttatacgt attctaacgg aaaaccgatt 1903621 cgtgattggg accgcaaata tctagggcct atctcaatgc gttacgctct ggcccaatca 1903681 agaaatatac ctgctttaaa agcattccag gcagtcggta aagatactgc tgtagacttt 1903741 gcaaatggac tcgggcttgg tttaacaaaa gataatgtaa cagaggccta ttctattggc 1903801 ggtttcggtg ggaacgatgg tgtttctcct ctgacaatgg caggtgcata cagcgcgttt 1903861 ggaaataacg gaacgtataa tgaaccgcat tttgtaaaat ctatcgaatt taacgatggc 1903921 acgaagcttg acttaacacc aaaatcaaaa tcagccatga gtgattatac tgcgtttatg 1903981 attacagata tgctgaaaac agctgtgaag acaggtactg gacagcttgc acaagtacct 1904041 ggtgtagaag ttgcaggaaa aacaggaacg actaactttg atgataatga agtcaaaagg 1904101 tacaatatcg ctagcggtgg cgcccgagat tcttggttcg ttggctacac accgcaatat 1904161 acagctgccg tctggacggg aatgggagaa aacgaggctg gaaagaaatc actttcagct 1904221 gaagagcaaa aagttgcaaa gcgcatcttc gcccagctca tcgccgatgt cgatgacgga 1904281 agcggatcat ttgagaagcc tgacagcgta gtggaagcca ccgtagaaaa aggttctaat 1904341 ccggcaaaac tggcagggcc aaatacgcca agcgataaga agctcacaga gtactttgtt 1904401 aaaggcacag ctccttctac tgtttctaaa acatatgaga aagaagaaaa agaggaaaca 1904461 gctaaactgt ctggtttaaa cgtgaaatac gataaagaca atcaatcttt aacgttaagc 1904521 tggaattacg acggagatgc gacctttgct gttaagcaat ctgttgacgg cggcagctac 1904581 tcggaaattc aaaacagctc tgcaaaagag gcagttattt cgggtgtgca gccaggatct 1904641 gtatacaaat tcgaagtaac agccgtcagt gatgatggca aaagtacagc ttccacatct 1904701 tatgaggtgc caaaagctga agacgatgaa gataaaaaag accagcaaca aacggatgat 1904761 gaaaaacaag atgatgagaa gactcaggat gatacacaaa ctgatgattc tcaaaaagat 1904821 gacggtcaga cggatcaaga tcagacagat gattcaacaa acgatcaaga caaaaaacaa 1904881 gacaatacga acaccaatcc gtccgacaac aataaccaag accaatcaaa cgataatgat 1904941 aacgacaaca gtaacaacca ggatacgtcg gatggtgatt cgaactctgg taagaatgat 1905001 tcaacaggtt ctgacacgaa taaaaataaa acagacacat ctaataaaac acaaacaaac 1905061 tcatcatcca ttgaaaaaac aaattaaaca aaaaagccgt cacctttggg gtgatggctt 1905121 ttttggtaca caataaaaaa cctcccgttt taacaggagg ttttatcgat tcatcgcatg 1905181 atatttataa aaatgctttt tcatttcggt aatcagctca tcaagctgaa taaagcaatg 1905241 gtattgggtc ggcttaagaa gaataaattc cactcgttca gcccaattaa tcggctttgc 1905301 gggatatgat ttctccctca gttcttgcca atcgagcgat ttcaccggct cacctgctgt 1905361 ccaatgtaac gaagccagca aacacacaat gccctttaac atttcgtttt ggtcacatct 1905421 cgattttcgt gtttgaaaga ctgggagaag tgatgctttg atgtcatccc acacttcaaa 1905481 taaaagcgga acgtatttcc cgctgtcctc ccatggcaaa tcgccttgta attccgtgca 1905541 gaaatcaaaa tacacgggat tggtctgcaa ggttttcttc atatccgagg aactcttctg 1905601 gccaagactg cgcaagtatt gctcatagga agccaacact tcttttgctt gcgtcatcgt 1905661 ttcaccagtc cttttttatc cctcttctgc ccttctctgc acaaagaaag cagcggacac 1905721 tccgcacagc gcggagattg ggctttacag tgatatctgc cgaagaaaat aagccggtga 1905781 tgcgtaacgg accaatcttc tttgggaacc ttgcgcatca gcgtcttttc aacttccaga 1905841 accgagtcct tccaccggca aatgcccaat cgtttgctga ctctctccac atgggtatct 1905901 acggctatgg ccggcacgcc aaacgcaacg gataccacta cgtttgcggt ctttctcccg 1905961 acccctggca gtttgacaag ctcatcgcgg tctctcggca cttctccgcc gtaatcttca 1906021 ataatcattt tactcagctt ttgaatattt ttcgctttat tacgatataa accgattgat 1906081 ttaatatcct gctgaagctc ttccagcgga acagccaaat agtcttccgg ccgtttatat 1906141 ttttggaata atgttttggt cactctgttt acaagtgcat ctgtacattg cgcagataaa 1906201 gcaacagcca ccactaattc aaaaggattg gaatgaacca gttcacactc cgcatgagga 1906261 aacatgtcac ctatcttgtc taaacagaat tcaatttgtt ttagatttaa cacgattgtc 1906321 accttttcac tttattgttc aagccaattg taaaaaggaa cctgcctttt atactctttt 1906381 tgcggttcat tctgctttgc ttgtacacgc cggaattttt ggctgtgtat ttttgcctgc 1906441 tccacagttt taagcccatt tttcttccat tcaaacaaaa tccggtcaat gtagcggaaa 1906501 ctgagttttc ctgatagtac agcctctttt aacgcgtgtt tgatcagttg tgcgtcatgc 1906561 tgatcctggt cctgccagat cgccagcgtt tcacactcca aaggcgataa cggtcttgcg 1906621 aactcttcct caaaaatggt ataaaggctt ttttgttccc cttctgcttt tctttcctgt 1906681 gtttgattct gtgcaagctg aatatactcg tacagcttgc cccataaagg ctgaagagaa 1906741 tatttctcaa atttgatgcc gttttgatcc tcgcattctt caataaacag aaagcctttt 1906801 tgaataaaca tccgcaatct gtttgtacat tcttcaacag aaattgacat accttcctgc 1906861 agctgattcg gtgtaggaaa atatgatcct ttttctaaat gcattttaat ttttaacagc 1906921 agaataagtt ctgtttcatt aagcccaagc tgtttataat gcgtgagcag aagattgggg 1906981 atggttgatg ttccctgctc ctgcatatca ataaattgct gttttttcat cgtcacacct 1907041 cttactgtaa aggattgtga ttgccccttt actgtaaaaa gtctcccttg caggagactc 1907101 ttttttgttt catttgaatg tattacggat acagacggtt taacagtctt gggaacggaa 1907161 tcgtttcacg aacgtgaggc gctccgctga tccaagctac tgtccgctct aatccaaggc 1907221 cgaagccgga atgaggaact gatccatatt ttctaagttc agcataccat ttataagcgt 1907281 cagaatccag tccatgttct ttaagacgcg attccaaaag ttccatatcg tgaatccgtt 1907341 cagacccgcc gatgatttct ccatagcctt ccggcgcaat caagtcagcg caaagcacaa 1907401 cgtcctcacg gtcagaagcc ggctgcatat agaacggttt taaggacgtc ggatagcgag 1907461 tgatgaatac cggtttgtca taatgttcag caatcgctgt ttcatgaggc gctccgaaat 1907521 catctcccca ctcgatatcg tcaaagcctt tttctttcag aaattcaatc gcttcatcat 1907581 acgtaattct tgggaacggg gctttgattt gctcaagttt tgacgtgtct cttcccaatg 1907641 tgtttagttc aattttgcaa tttttaagaa ctgattgcac gatgaaagaa acgtaatttt 1907701 cctgtacttg aaggttttct tcaaattcta caaacgccat ttccggttcg atcatccaga 1907761 attcgattaa gtgacgcttt gttttagact tttccgctct gaatgtcggt ccgaaagaga 1907821 atacttttcc taaagccatt gccgcagctt ccatgtagag ctgtccgctt tgagacagat 1907881 atgcatcttc atcaaagtac tttgtcgcaa agagttctgt tgttccttca ggtgcgcttc 1907941 cagtcaaaat cggcggatcc acttttacga agccttcgtt attaaagaat tcgtaagtcg 1908001 cgcgaatgat ttcattacgg attttcatga tcgcatgctg gcgctttgaa cgcagccata 1908061 aatgtctgtg atccatcaaa aattccgttc cgtgttcttt tggtgtaatt ggataatcgg 1908121 tcgcttcgtg aatgacttca atatctgtca cagcaagttc atatccaagc ggagaacgct 1908181 cgtcctcttt gacaatccct tttatataga gcgacgtttc ctgcgtcact gatttagctg 1908241 tttggaaaat gctttcttcc acttccgctt ttactacgac accctgaata aaaccggtac 1908301 cgtcccgaag ctgtaaaaac gcaattttcc cgcttgaacg cttattagcg acccaagctc 1908361 cgatcgttac ttcctcacct acgtgcttgt acacttggtt gattgttgtt ttcaacatat 1908421 ttccctccaa aacaagaaag acattcggaa gctcattgcc ccgcgaactc ttttatcatc 1908481 actttattat acccgctctt aactaaccgg gtcaatgcag ataaaaagcg gcttttctgt 1908541 cagccgcttt ttgatctgtt agctatgttt ttctacaaaa cgcttgattc tttcaatggc 1908601 ttcttcaaga agatctaacg atgttgcata agaaagacgg acattctcag gagagccaaa 1908661 tccggatcct ggaacaatcg caactttttc ctcctcgaga agcgctttaa caaattcatc 1908721 tacatctttg aaaccgcaag attgagctgc ctcttttgca tttgggaaca agtaaaaagc 1908781 accttccggc ttcacgcagc tgaaccctgg gatttctatg agctttgcat agatcgtatt 1908841 taatctatgt tcaaatgctt ctctcatttc ttccaatggc tcagaaggcc cgttataagc 1908901 agcaatcgct ccgtattgtg cgattgatgt cgggtttgac gtgctgtggc ttgcaaggtt 1908961 cgtcatcgct ttaataatgt cttcagagcc tgccgcataa ccgattctcc agcctgtcat 1909021 gctgtgggac ttcgatacgc cgtttataat gaccgtttgc tctttcagtc tgtctgacag 1909081 ctgtgcaatg gaaacatgtt tctttccgcc gtatgtaagt ttttcataaa tttcatctga 1909141 cacaatcaag atatcatgtt caaggcacac ttcaccgagc gcagatagtt cttcttccgt 1909201 atacatgaca ccagtcgggt tgcttggaga gttaataacg attgcttttg ttttttccgt 1909261 aattgcattt ttcagctgct caggcgaaat tttgaagtga ttttcctcaa gcccttctac 1909321 ataaacaggc tttccgccag cgagtttcac ctgctccggg tagcttaccc agtaaggcgt 1909381 tggaataata acttcatctt cttcatccaa aatcacttgg aaaagggtat acagagcatg 1909441 tttggcacca gtgcagacaa taatttgaga cggtttgtat tcaatattct ggtcgcgttt 1909501 aaatttctct gcaatgctgt ttttcagttc agccaaacca ccggaaggcg tgtatttcgt 1909561 atggccctcg ttcatcgaac gcacagcggc atcaataata tgctgcggtg tattgaagtc 1909621 aggctcgcct gctcctaagc cgatgacatc atggcctgcg gctttcagtt ctttcgcttt 1909681 cgctgtgatt gccagtgtgg ttgatggtgt taatgcggat actctttttg ccagtttcaa 1909741 cttgaactcc ccctaattcg tcttaaggcg tgatattttt gagaatcttt ccagttgtaa 1909801 agtccacata acttaaactg tattgccctt ctttgtctaa gtacgtcact tcccaaagca 1909861 ggacgtttcc ttctcttgcc agatgaacct ctttttgctt tgaaaccagc ccttcatcct 1909921 ttatgatttt cgccgctttg tcttcagaga ttccctcttt cgcttctttt gagagaattt 1909981 ttgctttttt atcagcagga acccagacat ataatgcagt gcctttttta tccgttccct 1910041 ttacaacata atatttttct tttccgacaa atgtttcgac ttgatcaaca tgggcgagat 1910101 cggtttcttt tttagcttca gcagctgctg cttcgtgccc ctcttccttt tgtgccatgg 1910161 ctgatttata aatgcttgcc gagacaagaa gtactgctaa aaaaataata ccaaaaatga 1910221 cggtaaatat taatgctttt tttctcatct tctcacctac gtacgataaa tggtaaaaac 1910281 ggcttggttt ttgttttctt catccagcgc aaggccgaac atcagattgt ctcttttcag 1910341 tgtacgattc aatgtgtcca caattttata cagatcatca gaatgctcta cattaattgt 1910401 tgaaagaatt tcgattttac tttccatttt ttcatcctcc agtttgaaca aatattgtta 1910461 gtcatactcc atttcaggac acgccatact agtatcacag agcgggaaat ccgcttttaa 1910521 ataaaacacc atcctactcc cacaccgcaa aagccgcttt atgcggcttt tattcttttt 1910581 cccctgcaac ataagcttca agctcgctgt cagtcatttc ggatactgag gttgtcggca 1910641 aggcatcaag aaacagccgg ccgtaaccag cggttttaat ccgtctgtcc aatataataa 1910701 tcgttccctt gtctcccgca gaacgcagca agcgtccgat tccttgcctg aaggtcagca 1910761 cagcttccgg taatgacact gtttgaaacg gattctttcc ttttttgcgg gcaagctcac 1910821 attttgcagc atgaagcggg tgatcagggg accggaatgg gagcctcacg atcattactg 1910881 tcgtcagctc atcaccaggg aaatcaacgc cttcccaaaa atgatttgtt ccgagcagga 1910941 tcgcctgatt ggatgtttta aaagtcttca tcagtttgcc gggacttccg cctgtaatcc 1911001 cttgtgccaa gagctgaatg ccggaagcac tcatgttatg cttaagctcc tggtgaacct 1911061 ttttcagcat atcatgggat gtaaacagca caaggatttt aggctgtttt tcctttgcca 1911121 tcagttcgat ataacgggct gtatcctgta taaattcagg ttgccctgta tcctgaattg 1911181 atttcatttc ttttggaatc atcacctgca tacgctcatc gtaagaaaag ggtgactcaa 1911241 ttctcattgt ccgcgggaaa aagtcactca gtcccagtcg ttcaatcata aattgaaaag 1911301 aaccttcgac tgtaagagtt gcagatgtca gcaccacact atttttgcgc gcgaaaaact 1911361 gatcagccag aagttcacca ggttcaagag gctgtgcgta aatggccact gcatttttcg 1911421 caccctttgc atctatttca atccaaaccg cttcatcgtc atcagagcca aagaagagct 1911481 tctgcaacgt ctgacagtaa tgctgcaagc ctttcatgct tctttggtat tcatcggcta 1911541 aaaagacggt tttgctcttc atgcccttca aatgtttttc cataagggat gactgcgcct 1911601 caaaaagctg ctgcaaatgt gtcagcatgg aacaaagcct ctccgcacca tctgttaaga 1911661 tcgaccagct tttatcctgg ctttctttgt tcaccttaaa cactagacgg tttaagtctt 1911721 ctttaggttt tcttcgtttg acaaaagaat gtacagagct aaagaaagca tcactttctg 1911781 cttgaacgtg ctgaagccac tcttccaatt cgaaaaatga atcaaccggc aggctgtttc 1911841 gctggaatag ctgtctcatc ttttttagaa gtccctgctc cttcagagtg ccgattctgc 1911901 tcaatttcgt atgcaattct atgtacgtgg ctcttttccc taaatgttcg cttgccgcac 1911961 gttcaaaatg gtgtgcttca tcaataataa atgtgccgct ttcgggaagc ctttttttat 1912021 ggctgccttc atcggtcagc aaaagagaat gattggtgat caccaaatcg gaacgcatag 1912081 caatctgttt ggcccgctcg taaaaaccga tcacatgctc actgcgactt cttttatagg 1912141 agtcatcgtc ataagccaat ctgtcccaca gcaattttcc gcctgaaggc aaattcagtt 1912201 ccgctacatc tcctgtattt gtctctgtca gccaaacaag aagctgtgcc tttgtcagta 1912261 cggcatcata attatcatct tcttcatgaa gcacctgctc aaatttatac aggcataaat 1912321 aatgcgattg cccttttaaa atcgccgctg ttaccggaaa tggaaacaga tcttggacaa 1912381 tcggcaaatc ctttgtgaga atctgctgct gtaaaagcgt cgaatacgtg ctgattatga 1912441 ccggcttttt tgatttcttg gcaaaaagcg cagccggaat aagatagcca atcgtttttc 1912501 cgatgcctgg aggagcttca atcagcgcat gctcacgatt ggcaaacgca tcagccacct 1912561 ctctcatcat catcatttgg ccgtctcttt tttcataccc aggcattaac tctgacagcg 1912621 ctttttcatt tcccgcttcc cagctttcga tctcaaatga gaagttctcg tcctcattta 1912681 tacgaacatc gatagcttca ggttctctga cagaaaacga agaaaagcgc gtatagcccg 1912741 gtatctcggt atgtctgttt tcattaatga acatatccaa caaatgcgtc agatcactga 1912801 tgaaatgctg cgaaagcctt cttaactgct ttaatgtcgg ataaggaagc tgccgcagct 1912861 tttcaaggat ttccaaaaaa ataagccctg tcacttcagc atcgctgtca gcccggtgcg 1912921 gctgatcatg ccgcagctga agctcctcgc ttaattccgt cagcttatac ccttcaaatc 1912981 ccggaaaaac aatgcgtgag agctcgacag tatcaagcac ttcacaatct gggagctgaa 1913041 agcccgcctt atgtagctca tacttgacaa atccaaggtc aaaatggata ttgtgggcga 1913101 caaaataagc gccgtcaagc aattggaata cttcttcagc aactgcttca aatggctgtt 1913161 cattctcgac catttgatta gagattccag taagctgctc aataaaagca gggattgatt 1913221 tatttggatt aatgtatttt gaaaaccgct cagtaatttg tccattttcg attacaaccg 1913281 ctgcgatttg tatgatttta tcgcctttct tcggcgaatt ccctgttgtc tctacatcta 1913341 taacaacgaa ccgttgctta ttcattaaaa tggacacctc aattcttgca tacgacaaaa 1913401 gtgtaacacg ttttgtacgg aaatggagcg gcaaaaccgt tttactctca aaatcttaaa 1913461 agaaaacccc cgataaaggg ggcttttctt ctacaaaatt gtacgggctg gttcgttccc 1913521 cagcatttgt tcaattttgt tttgatcatt cagaacagcc actttcggct catggcttgc 1913581 cgcttcttga tcagacatca ttttgtagga aataataatg accttatctc cttcctgcac 1913641 aaggcgtgcg gctgcaccgt ttaagcatat gacgccgctt ccccgtttac caggaataat 1913701 atacgtttca agacgtgctc cattattatt attcacaatt tgtacttttt cattaggaag 1913761 cattcccaca gcatcaatga gatcttcatc aattgtaatg cttcccacat agttcaggtt 1913821 tgcttccgta acagttgccc tgtgaagttt gccgctcatc attgttcgat acatattata 1913881 ttctctccat ttctcgaata tcaataatga tattatctat taaacgcgct tttgaaaaag 1913941 caactgcaac agcgagaatc atctttccag caatttcatt cacaggctcg agttccggat 1914001 aggaataaag ctctacatag tctatggttc cgctagtcgt ttcaatgata tcttttgcag 1914061 cttttatcac cgcttcagga tctctttcac cggcttggac aagttccgca cttgtttgaa 1914121 gggcccgata cagcttaggc gcttcttttc tttcctcagc tgttaagtat acattgcgag 1914181 agcttttggc taagccgtct tcctctctga ccgtatcgac aggaaccaat tcaatatcca 1914241 tgaagaagtc gctgattaac ccatcaacaa cagctacctg ctgcgcatct tttaaaccga 1914301 aataggcacg agtcggcttg actagattga aaagcttcgt cagtacgatc gcgaccccgt 1914361 caaaatgtcc ttctcttgag cgcccgcata acacgtctgt gcgtctttct acatgaatcg 1914421 tgacattctt ttcaccggga tacatatcat gagcatctgg cgtaaaaaga atatcgactc 1914481 cggcgttttc tgcaagagct gcatcccgct caatatcgcg cggatatgct tcaaaatctt 1914541 cattagggcc gaattgtgca ggattcacaa aaatactcat aataacggcg tcgttttctt 1914601 gtcttgcttt gtctgctaag gttaaatgcc cctcatgcag aaaccccatc gtcggaacaa 1914661 atccgattga cttgccctct gaatggtatt gttttatggc ttctttcagc tgtgaaatat 1914721 cagtaatctg tctcatctta ttttcccccg tacaagccgt caagcactgt ctggttcatt 1914781 tgaaaggaat gcttttgttc agggaaagca cgatgtctta catcctgaac atatccgctg 1914841 attgctgttt cgatggtttc atcaatgcgc gtatattgct ttacaaattt aggtgttctc 1914901 tcaacaccgt ggccgataat atcatgataa acgagaactt gtccgtccgc tttcacacca 1914961 gccccgattc caatgaccgg tatgcttagc gtctcggcaa ttttggctgt gagttctgcc 1915021 ggcacacatt ccagcacaag catcatagct cctgcttctt cgcattttat actgtcttct 1915081 attaattttt tggcgctttg ttcgtctttg ccctgtactt tatagccgcc cagtacgccg 1915141 actgactgcg gtgtcaaacc taagtgactg actactggaa tgcctccaag cgtcaatgcg 1915201 cgaatggatt caaacacgcc ttctccgccc tcaagcttca gtgcgtcagc tccgctttcc 1915261 tgaacgatag ccgctgcatt tttcagcgta tcttccttag acaggtgata agacataaac 1915321 ggcatatctg tcacaataaa ggtattcggc gcaccccttt taacggcttt tgtatgatgg 1915381 atcatgtccg caactgtcac accgacagtt gaatcaaggc cgaggacgac cattccaagt 1915441 gaatcaccga ctaaaatcat gtcaactccc gcttgttcag caagtttagc tgccggataa 1915501 tcataagcgg tcagcatgac aatcggttct tcagactcct tcatttttag aaaatccagt 1915561 tttgttttca tgttttctcc tcctcatgtt tagaggagat gatctgccgt tttcttctgc 1915621 aagccaaaaa accttccgtt acaacgagaa ggattcttca ctttctaaag ttcggcgagt 1915681 ttcatccctc tgtcccagtc cttttttgga tcaaggcaga ctgctgcaat gtctatctat 1915741 tttaataata ggtgcagttc gcaggcgata ctgcccaatg gaagtatacc aaaatcaacg 1915801 ggcttgtacc aacacattag cccaattcga tatcggcaga atagattttt ttaatgcctt 1915861 cgttcgtttc taaaagcaga acgccttcat catctatacc taacgcctta ccgtaaaagg 1915921 ttccgtttaa cgttctggct ctcatattag tgccaatacc gagcgcatag ctttcccata 1915981 aaagcttaat cggcgtaaat ccgtgcgtca tataatcccg gtaccgtttc tcaaagcata 1916041 gtaaaatatg ctggatgacg ccggcccgat caattttttc cccagcagct tggctgaggc 1916101 ttgtcgcgat gtccttcaat tcatctggaa aatcattagg ctgctggtta acgttaatgc 1916161 cgatcccaat gatcactgaa cgtacgcggt cttcttcagc ctgcatttcc gttaggatac 1916221 cgactgtttt ttttccgtta atcaaaatat catttggcca tttaatatcc gtttggatgc 1916281 ctgctgcctc ttctattccc tgcacaacag ctactgcagc aagcagagtc agctgcggtg 1916341 ttttttggag cggaatgtca ggccgcaaaa tcaggctcat ccaaacaccg tttccttctt 1916401 gagaatgcca taccctagac attcggcccc ttccggctgt ttgtttgtca gccaccacaa 1916461 gggtgccttc cggtgcgtta ttattcgcga gctcatgagc cgttttttgc gtgcttgaaa 1916521 gaacgtcatg gtaaataaga tgctggccca tcacttccgt ttttaatcca aaacgaattt 1916581 cgctttcact gagttttccg ggttttttga tgagccgata tccttttctt ctaacggctt 1916641 ctacttcata accctctttc cgaagctctt caatatgctt ccacacagca gttcttgaac 1916701 agccgagagc atcactgatt ttttggccgg aaataaattc attgccggcc tgagaaaata 1916761 attcaataag gtcttttctt aatgttgacc gcatgtcttc agccactcct ctatgtgttt 1916821 cttttgattg gagagcttcc ctgtcacaac agcctgctcg atccactgta attcttctga 1916881 cacccatttt ccggccggcc ggtttcgaag cgcaagcaag tccttacccg tgatatcaag 1916941 atccttaagg cttttgatcg gcaggttttg ataagcgtac tgaatgtcct tcagtttctt 1917001 ttcatccagt ttttcgtttt gccgaagctg cgatattttg gccgctgaga gcagtgcttt 1917061 tttcccagct ctgtacattg tcattgcgtc aaggctctgg ccaaacgtat cggcaatgtg 1917121 aatggcttcc ttgatcactt ttcccgggag cttccaggct ttcaggaaaa ggggcgcgtc 1917181 tttcaaaact atgccaaggt taattaaaag agcagcccaa agctcctcac gggatgttaa 1917241 agagaagaat ggaaactcac tcgttgaaat caggttttct cgtttatgat aaaaaccagg 1917301 aagctcttca tacaatctcg tttgaatgag tgtttgaagc gcctggcgag aagctcttcc 1917361 ctgcagcaat ttctcaaact ctatagtttt tcgttcgact gaaacatggg agaggagtga 1917421 tttttctttc gcaatggctt cttctgtttc cggtgaaagc gtaaagccaa gctggctcat 1917481 aaagcgtacg gctctcagca tacgaagcgc atcctcttga aatctatcct caggctttcc 1917541 aacggttcga atcactttct gatcaatatc tttcttgccg ccaaaataat caagcacctt 1917601 cccgtccgct gtcatggcca tcgcattgat cgttaaatct ctgcgtttta gatcctcttc 1917661 taatgatgag ataaattgca cttctgacgg tcttctgaaa tcaacataat cagattcagt 1917721 ccggaatgtc gtgacttcat aggtttcatc ctcccagagc acaataatgg tcccgtgctc 1917781 tttgcctaca tcaacagtcc gctgaaacag ccgttctact tgatcaggtg ccgcatctgt 1917841 cgcgatatcg acatctccga tcgttcgttt catatagctg tcacgaactg cgcccccgac 1917901 aaaataagcc tgatggcccg cttcgattaa gatgcggagc acgggaagtg ctttgataaa 1917961 aactttttcc atgtgatcac tccggttctg ctaaatcggc ataaatctgt tcatactggc 1918021 tgacaatttt tttagaagaa aattcatttt caagcatctc tattgccgcc tttgtaaaac 1918081 gattgcttag ctgttcatct tctaaaatgc tcatcgcgcg ggctgttgcg gccgtaacat 1918141 caccgacatc caccaaaaat ccgctcacat tgttttttat aacctcaggg ataccgccaa 1918201 tgtttgttcc aatacaaggc actccgcaag ccatcgcttc aagcaggaca aggccaaagc 1918261 tttctttttc agatagcagc agcttcaaat cgctaataga ataaagatct tcaacacggt 1918321 cttgatttcc aagcattaag acttggtctt ccaagccata ttttctgata agctcgcagg 1918381 ctgtcgattt ctccggaccg tctccgacta aaagcagctt cgctttcgtt ttgccagcga 1918441 tattgcggaa cacacggatg acatcctgca cgcgtttaac ttttctgaag ttggacacat 1918501 ggatgacgac tttttcatct ggtaaaattc catgtttctc tttaattgcc gctgtgtttt 1918561 tcttcagata cacgcgctcg tctataaagt tataaatcgt ttcaattttt ttctccggtt 1918621 taattaaatc gtatgtttca gccgcaagcg ctgaggagac ggccgtcacc ctgtctgatg 1918681 actcaatagc aaaacggatc agatctttta gagacggatc ataacctaac accgtgatat 1918741 ccgtgccatg caaagtggta acaatgccga tattgcgttt cagcatttgt tttgcaagat 1918801 aggcgcaaac ggcatgcggg agagcatagt gagcatggat aatgtctaaa ttctcccgtt 1918861 ccgccacctc agcgattttg cttgccaatg tcaaatcata cggaggatac ttaaaaacag 1918921 catattgatt aacctcaact tcatgaaaat gaatattggg atgatatgta ttcagtctaa 1918981 acggaatgct tgatgtgatg aaatggattt catgtccctt ttcagcaagc tgcttcccca 1919041 gttctgtcgc aatgatacct gagcctccaa cgctcggata gcatgtgatt cctattttta 1919101 gttttctcat tgttcgcccc caagcacatc atgatcaagc atcagcatcc gtttggaaaa 1919161 gaaaccttcg gcatactcca cgcccgcttc tttaccgtaa agcttttctc tcgcttcaac 1919221 gatttcaata tacccattcg tcagaggagt agaaacggaa tcctttgacg ggataaactg 1919281 gcttttgtag gcgttgaggc tttgtttctt tgcctctatt gtatccgaga tatcaataac 1919341 aaaatccggc tgatgaaaac catttatcat ataatagtaa accttgctga ctttatgcgc 1919401 cggaaggctt ttttcgtctt tatatttatg gattccggcg gaaaagatcg cttcttccac 1919461 cagtgcagcc gcattgccgt gatccggatg gcgatccttt ttatacggca taaaaaccgc 1919521 ttttggccga cagattctga tgacagtgac aattgaccga attgcctgat cactcattat 1919581 taggccgcgg tctggaagcg ttagctgaat tcttttatct gcgcctaata tgcgggctgc 1919641 ttcagctgct tcttctttac gcaaactgac cgtaccgtta gaagagagtt ccgcttctgt 1919701 caaatcgcat atcattactt ttttttcctg tttgacaaac ttcgctattg tgccgcccat 1919761 tccgatctcg acatcatcac tgtgggcgcc aaaagcaaga acgtcagcat tatacattcg 1919821 gctcttctcc ccgaagaagg tcacggaatt cgaaaacacc ttcatcaagt gtgcgcacaa 1919881 gaatttccgc agtacccata tttgtggcga gcggaatgga atacacatca cataaacgga 1919941 ttaatgccga gacatccggt tcatgcggct gcgcggtcag cgggtcgcgc aaaaaaatga 1920001 caagatcgag tgcattggca gcgatcagtg caccgatttg ctggtctccc cctaaagggc 1920061 cggattgaaa acgttcaatt tgaagacctg tcgcctcatg aattttcaac cctgtggttc 1920121 cggttgcgta tagatcatga ttctttaaaa tatcccgata ggcagtcgta aattgaacca 1920181 tatcctgttt tttcttgtca tgcgcgatca aagcaatttt cattgtttat ccccccgtct 1920241 aatcaatgat attttctaaa ccatacacaa gctgatcaat cttcatgact tgttcgactg 1920301 acagtttaac gcctgacatg aaagaagcac ggttataaga atcatggcgt atctgaagcg 1920361 tttggccatc catgccgaac atgacctcct gatgcgcgat cagtcccgga agacggacgc 1920421 tgtgcaagcg aataccgttt tgctccgctc ctcttgctcc tgggagaatt tctttttcat 1920481 ccggatgtcc ttgctgcttt tctttacgga cttctgaaat catttccgct gttttaagcg 1920541 cagttccgct tggtgcgtca agcttctggt catgatgaag ctcaataatc tcaacatcct 1920601 caaaatagtt ggcagccatt tttgaaaatt tcatcatcag tatcgcaccg agcgcaaaat 1920661 ttggcgcgat gatggctccg atcccttttt cttctgttaa agatgtgagc tcttttaaat 1920721 cagcttctga gaaaccggtt gttccgacaa ctggacggac tccgtgctct aatgcaattt 1920781 ttgtatgtac ttttccgatt tcgggcgttg ttaaatcaat caagacatcc ggttgtgttt 1920841 ctgtaaaaca ggcatggata tctgtgtaaa tgaaagcatc tgactcaaca ggcatcacat 1920901 cagataattt ttgctgatcg tatgtatggt ctatggcccc tacaaggtca aaatgtggtg 1920961 ttcgttctgc caatttaaca gcttcctgcc ccattcttcc acgcggtccc gcaatgacta 1921021 atttaattgt ttcgtttgac atcttgatct cctctacttt ccttcttctt ttctggtcca 1921081 gcgatcttta tctcttgtat taaatttatg catgactcgg tcgtgagctt cctctaaaga 1921141 gatatcaaga gagttggcta aacaaaccaa tacaaatagc acatcgccta tttcctcttc 1921201 catgctttta tcatcttcag tcgctttttt tggtttttct ccataacggt gattcacttc 1921261 tctggcaagc tcgcccagtt cttcagtcag cctcgccatc atggccagcg ggctaaaata 1921321 tccttcttta aattggccta tgtaacggtc tacttcagcc tgtatgtctt tcattgtttt 1921381 atcactcact gaacgaaacc tcctatcatc ctcttacatg ttagctaatt cagatacgtt 1921441 tgacaaatgt ttaagcacgt ttgctgtttt ctttttcatc cactataata taaacgctat 1921501 ctaatggaag gaaaaggggt tttgtgtgat gcttggagaa attagattaa aaaacatatt 1921561 ttttatttta atcggagcgg caattttttc atttggcttg gttcatttca atatgcagaa 1921621 caatctggct gagggcggtt ttacaggtat tacacttttg ctttatgccc ttttccacat 1921681 cagcccctct atatcgaacc tggtgttgaa cattccgatt ttttttattg gctggcgttt 1921741 gctcggcagg acaatgtttg tttataccct tgtcggcact gtagccttgt ctttgttcct 1921801 cagcatcttt cagcgatatg aaatccatat gccccttcag cacgacttag cgctcgccgc 1921861 tttatttgcc ggcgtattca tcggagccgg actgggtatt atttttaagt tcggcggtac 1921921 gacaggcggt gttgatatca tcgcacgttt agtgaataag tattttggga ttccgatggg 1921981 cagaacgatg tttgctttcg atgcctgcgt catcattttg tctttgctta cttatctctc 1922041 ctataaagaa gcgatgtata cgctggtagc tgtatttgta gcggcaagat taatcgattt 1922101 tattcaggaa ggcggatacg ctgctaaagg cgctacgatc atctcttcga aaaacgacct 1922161 gattcagaaa aagattcttg aagaaatgga acggggcgtc accattttga aaggacaagg 1922221 ttcctacaca aaagaggata tagatgtact ttattgtgtg gtgccgaaaa atgaattggt 1922281 gatgctgaaa agcgtgatta actccattga tccccatgcc tttgtagcgg taagcgatgt 1922341 tcacgatgtg ctcggagaag gatttacgct tgatgaaaat aaaaatccgc ttccgcgctg 1922401 acatgtaata gaaaaaaggc ggctgaccgc cgcccctcat ccttatttag ggtagtccct 1922461 ttttttcagc ttgttttttt ccgccttgta ctttctgtaa ccgacatagg taagagcagt 1922521 aatgatgata ctgccggttg taatgatcac ccagagtaaa gacggatcgg catcatcctc 1922581 ctccaccctg tcaaacacat ttttcaggtc atgctgaaga agggaaagcc gttcaagctt 1922641 cgtgctctct gtcatttgct gaaattcctc ttgctcaata acatctatat gttttccgac 1922701 tgtttcaagc tgatcctctg atacatcgat tgtaagactg gggtaaatca agtcatataa 1922761 actgataaat tcattccatt tttcatgaaa gcttgtgctt ccattctttt ggacatctcg 1922821 cttcagttca gtaaaagctt ccataatcgg tttttccagt gagccccaaa gcgggtcaga 1922881 ccgattgtca accgcatcca tcagcattct gaactgcgcg gctgctctga gtttttgtgt 1922941 gtctgatgta tcagcttgct ttaaactccg aaccatatca ttatagccca atgtgatttg 1923001 acgaatttgg gctcccgtta gcatggggtc ttgctgtttt ttctcagcgg attttaatgt 1923061 tttttcaaaa tactccaaga cttgaagcgc ctcttcatat ttcgcctgtc gggtcatttg 1923121 aaagactgta tcggataaat cattcaattc ctcgaggctt ccccgctctg cagccttggc 1923181 atttccatta taaaaaataa gtgcaatcaa caaacagatc gtcagctttc gtttcatgca 1923241 ggtccctccc actctctctc cttacagaat atgaagaaag ggacaaggat agaccaacat 1923301 tgtctttaca tcagctcaag cttcgtttgc ttttttgaga ccacaagaaa gtaagcaagc 1923361 gcgattgaaa agatacttag ccaaaatgtt ccgtatccta tttcagtcat ataatcagaa 1923421 agcatagagt attgcggcat catatcaaac aagtagtcaa tgacatcgtt atgcagtgtc 1923481 cagactgcag caattgcaag atgccaaaat gaaaaacgaa aatacggact gtataatacg 1923541 ccttgaactg ccattgcaaa atgcgaagca attagcatgt agccctccca cggcaagtca 1923601 ccagttactg caagcacaag aaaattcata gccaccgccc ataggccata ctttacgagg 1923661 gtaactagcg caagcgcctc taaaagcgga gcattccgtt tcatgagaaa ggcaagcagc 1923721 acaaacagaa agaaaaacgt tgctgtcgga ctgtccggaa caaaaatcag gaaacgggcc 1923781 ggtgtctcca aaagctgcgg caagtaccaa tagtagccgt aaaccgttcc cagaaaatta 1923841 atggctaaga caagaataag catcggccgc tgccctaata catattgaaa ccatttcaca 1923901 tcgaatcaac tctcagtctg taaaaataat atgtccatat aaaaaagctg acgccgggtc 1923961 agcttttgat aataaaagta tatccttcca tttgacaatt cacaatacgt tattttgcgg 1924021 ttgtttcaga aataaatttt gcaagttctt cgagctgctt atcatttcct ttgaacacac 1924081 ccgccggcat tttgcctttc ccttctacag cgattttttt gatttcatcc ggtttcagcc 1924141 cgctgtcaac caatgaaggc ccggccgctc ctccctgaag gttatcccca tggcaagaaa 1924201 tacagccctg ttccttaaaa accttatatc cttctgcatt ggtgtcaatg tcggcttctt 1924261 ttgtaatttt cccctgttct tctgccttgg cccagtcatg agtagcaact gactgccacg 1924321 tcaaaaatac agcagcggaa atggccagaa gcatcatacc gacagcgacc ggacgcttcc 1924381 acggccttct ttctgtccct ctgtctagga atggagccaa aagcagggcc ccaaaagcga 1924441 gacctggcat aatcatggcg ccgaccactg taaagcttcc ggcggcgtat tcatacttca 1924501 acagctggta taagaaaaga aaataccaat ccggcagcgg aatataacca gtatcagtcg 1924561 ggtccgccat ccgctctaaa ggcggctgat gcacaatcgt caaaacgaga aaaccgatga 1924621 gaaagacagc tccaaccatc cattccttta acaagaaatt tggccagaaa gcctctgttt 1924681 tacccggata ctccgaataa tccttcggta tattcggctt tttttcagcc ggtatccttg 1924741 agtcgcctac aaatttcatc cctttgcccc ggtgcatgtc atcccctccc ttttattcgc 1924801 agatcaagag tttaaagcgg tcctgaaatc ccctgcttcc ggatcataat aaaatgtgca 1924861 gccatcagcc cgaacaatgc ggcaggaaga aaaaatacat ggatcgcaaa aaacctagtc 1924921 agcgtttggg cgcctacaat atccggatgc cctgcaagga gcgttttaac ttgcgttccg 1924981 atcaaaggcg tggcttcggc gatctgcagt ccgacttttg ttgcaaacag agccttcata 1925041 tcccaaggaa gcaagtagcc tgtaaagcca agaccgagca taacaaaaaa gatcagcaca 1925101 ccgacaatcc agttcagctc gcgcggtttt ttatacgcgc cttggaaaaa gaccctcagc 1925161 gtatgtaaaa acatcatcac aatgaccagg ctcgcacccc agtggtgcat ccccctgaca 1925221 atctggccga atgccacttc attttgcaaa taatataccg attcccaggc atttttgata 1925281 tcaggcacat aatacatcgt taaaaacatt ccagataata cttggataac ggttacaaaa 1925341 aacgtcagtc ccccaaagca atacacaaac gcagagaaat gatgggcggg attcacatgt 1925401 tccggtactt cgtgatcggc aatatccctc cacatcggtg taatatcaag ccgctcgtct 1925461 acccagtcat aaattttgtt cagcatgtca cccttccccc ttaggctttg cttttccaag 1925521 atacaggaag ccgtctttta cttcttgctc ataatgatca agaggcgcaa gcggcggcgt 1925581 gccagggaca ttggtgccgt ccttttcata gagtccgtaa tggcatggac aaaagaattt 1925641 attcgggttt ttaggatcac tattccagtt caccgtacac cctaaatgct tacaaattgg 1925701 cgaaagtgct acaatttcat ccccgttttt gaagacccag gctgatcttg actcttctga 1925761 ctcataccag gcatcgactt gattaatttt aaaatcaaag cgctgcggct cttttgtcaa 1925821 ctcatcaacg ctgacaacct gaaccatatc ctgcttccct gtcgatttta ataccgggtc 1925881 gagtgcgaag cgaaccatag gcatgagcat actagccgcc ataaaacctc ctacgcctgt 1925941 gagcgtataa ttcaaaaatt gacgtctgga tatatcatgt tttccgccca tctcttctcc 1926001 cccctctaag tcacccctgc aaactgacta aaatagaaaa tattgcaata actctagaca 1926061 ccctcataat atatgaatct ctcagcaagg tcaatatagc caaaatattg tttataagga 1926121 aatgtaagtg tttttataaa gtgctccata actgtaacaa aacgttcaaa atttcagcag 1926181 tgcgttcatc caatattttt ctttttaaag agtcatttaa atgctctaat ggaacagacg 1926241 atgtaacaat cattttgcct aacgcatcct cagctctcca actttcgtca gatgtgagca 1926301 ggacaacatg cggaaattcc gttatcagct cttcccgcaa atccttaagc ccttgaacgg 1926361 ttatttcatt tctatcaaca tatgtataag gcggaagtaa atatacccgt ccctttaact 1926421 gcctttcaag ttcttctgag agaagctgcg taaactcgcc tttctccgcc gccattttaa 1926481 aatggttatt aacccttatg ttaattaatg gtatgacagc ggtatcaatg taatccttag 1926541 cttgtaaata gtccttggca tcagtgattc tccacctcat cgttctcccc ctttacggca 1926601 acaagccttg caattcactg caaggctggt catattatgt gagctgattt aattggcgcg 1926661 ataattgttc aaatgcctct ttatcatgac gatctaacgc gtcgtcaatg tcttttaata 1926721 atttttctct ttggaatgtg gaaatagcgt gctctaaaat ctgttccgcc aatccctgat 1926781 cttttttatt ctcaaaaagg tttttcggaa tatgcgggtt ggactccagc accgccgcat 1926841 attcaggtga gctgtaagcc gaacggaaat taagctggat aaacaaatcc tgctgtttat 1926901 ttaatctaat atcatgaaaa gatttttccg cgtcggtagt catgacattc tctttataga 1926961 accggaacgg aacttcttca acacaatgtg ttgacattat aatgcctctc gggcaaaatt 1927021 cagcctgctc cacaaaatga accttctcca tgagagaatc atggctcatt aagtagttca 1927081 agatccaaac gcactctcgg cgctttaact gataatggtt taaaaaccaa cggataaaat 1927141 cttttttctc attgacagaa acaggggtct gcatgtaatt ccctcctcta tcgttcgtat 1927201 aatctatata cttatatgtt ccacatgaat ggttaatatt cctgcttatc tagaaaattc 1927261 atcctcgatt cgcaaaatcg tttcttcaag ctcttcattg gctccgtcca tttcaagaac 1927321 ctttttcaaa agcggcagcg cttctttttg aagaccttct tctaatagga agcttgcgta 1927381 ttcatataag aaatctctat cctcccggta atgaagatag gcagcctcaa aggattgttt 1927441 tgcttcctcg tattgctcta attcagtata tgcgcttgca agataccaat tgtatttagg 1927501 atcttcttca ccgtagcttc gaacctcttg aataagatca atgatctgat cataatcctc 1927561 ttctttgtga tacacggcaa gaagtgtatg aagcgcctcg acaaagcccg gatcaagcgc 1927621 aagcgcctcc tgaagcagct tcttcccctc ttctgacttc ccgattttca aggccatttt 1927681 ggcggcataa aggaaaagtt ctttgttata ttcatcatat ctgatcccct cttttgccgt 1927741 ttttaatgcc tcttcataca ttccttcagc ttcatagctt ttcgagagcg gcatataaag 1927801 tgaagtataa gatggatcaa gctcctttaa atcagacagc tgcttaatag ctgttttcac 1927861 aagccccgcc tgtaaggctg taaaaccata gccgaaaatc gtattaggat caggattctc 1927921 atcgacagct ttctcatacc atggaatggc atcctcaaat tcacctgagg cacttaacga 1927981 ttctgccagt ctttgatgga cattaacgcc cccgatctca ctctgctcct cagccgttgt 1928041 tttaaaatat tgaaccgctt ttgcataggc tccctgagca aagtaaagtt ctcccagtgc 1928101 aaaatcaata acaggttcat tgtccagaat ggactttgcc tggaaaagct tttgttcact 1928161 gacttcgaat aacccctgca tctgataaag atccgccata agcagcaaac tttccggata 1928221 tgatggatct gtttccggaa tagtctccag cacagcgagg gctttttctt cttcgtcaat 1928281 atctattaaa agttcagcgt agaaattcgt cagttctgtt tcatttggat ataaatcatg 1928341 tagatcacta atcagtgaaa tggctttttc tacatcgccc cactcgtaat aaagctgggc 1928401 tgcaatggct ttatcttcat catgcagctg tttttcagcc ttcgagagcg tgttgaggcc 1928461 tttttctgtt tcacctgctt caactaattt tatggcttct tgaatcaatg tattcaaatc 1928521 ggaccggtcc tttcttttcc tatacaacat caaccataca aaaaaagctt tatttgttcg 1928581 ggttaatctt atcataattc agacgaatgc ccccggcaaa taagatgctt ctgtacggaa 1928641 gggaattatt gagtcttatt agtttaccaa aagatcttga gatagaaaat gaaaaaagga 1928701 agatcgccct ctgtacagta aagcagctct ttgacctgcc ggcttgtaag taaagcacat 1928761 cccccctttt cgtttttcta tccgttctat aagacaagct atgttttttc gcctcgaatt 1928821 atgatctgca taaaaaatcc tgaagtaaaa cttcaggatt ttttcgaaag cttatttaaa 1928881 tgctcgaaga aggttggata agaaacgtga atggcatccg tgtgctcgat ttcaatcggc 1928941 tcctccgtta tacaggaagc aataccaagc atcattccga ttcgatgatc tccgtggctg 1929001 gacactgcag cgccgccttt caacgtttgt ttgccataaa ccttcattcc atctgctgtc 1929061 ggttcaattt cagcacccag cttgcgaagc tcagaaacaa cagtatcaat acggtttgtt 1929121 tctttcactt ttagctctgc cgcgtcctta ataacggtgg ttccttccgc ctgagtcgca 1929181 agaagcgcga tgatagggat ctcatcaatt aaacgcggaa tgatatctcc tccgatttca 1929241 actgccttta gagatgacgt ttctataatc aaatctccat aaggctctgc accgctatca 1929301 gcagatggtt tgatttcaag ttttgccccc atgttttgaa ggacatcaat aatacctgtc 1929361 cgagtcggat ttaaacctac gtttttcaat acaattctgc tgtttggaac catcgcgcca 1929421 gcagcaagga aaaacgcggc tgaagaaatg tctccaggaa caaaaatatc agcagctgtc 1929481 agtttctggc caccagcaat ggaaacactc gtttgatctt cagaaagctt aacgccaaaa 1929541 gcagaaagca tccgctcagt gtggtcccga gatttatggg gctctgttac agttgttgtg 1929601 ccctcagcct gtaatccggc cagcaaaaca gcagatttaa tttgcgcgct tgcaacaggt 1929661 gatacataat caattccttt taatgaagcg ccgctcactg acagcggtgt aaactctccg 1929721 ccggctctgc cgtcgatttt agcccccatt tttttcaaag gctcagtcac acgcttcatt 1929781 gggcgtttcg caatgctctc atctccggct accgcgctgt aaaaaggacg gcccgccaat 1929841 attccgagca tcaggcgaat cgttgtacct gaatttccga catctaaaag gctttctggc 1929901 tctttcaggg catcgattcc ttttccgtga atcacgacat cgctgctgct ttgctcaatg 1929961 tgaacaccca tttttctaaa gcaatcgatc gtgctcagac aatctgctcc cggcagaaag 1930021 tttttaactg ttgttgtgcc tgccgctagc gcgccaaaca taacagagcg gtgagaaatg 1930081 gatttatcac cgggaatatg tatttctcca tgtaaggtct gcaccttatc tcgtttcatt 1930141 ttttccacct caatcagcat aaaaagtttc atattccgcc cgggcttcaa tgcattgttc 1930201 tgcccttttg cggtcgtcat cagactgaaa actgatcctt aaaatcccgt taatatcctc 1930261 tcgtgtttcg ataatgcgga tattcgtgat actgatgcgc tccgcagcta agatcgctgt 1930321 tatctcggat attacacccg gatgatcggg tacatccaca tataaatcat aaaatgcagg 1930381 tatcgctccc ttctgccgaa gcggcagccc gtcgcgataa tccttggctg ttttaaaata 1930441 acgaaataga ttttccgcat cttcttgttc tacatatgta cggatcttgt caatttcacg 1930501 aatccactca tcaaaacggt ctaagatttt atctttatta tgtaataaaa tatcccgcca 1930561 cattgccggg ctgcttgatg caatccttgt aatatctctg aacccgccgg cagcaaaacg 1930621 cttaacaagc ggatacaggt tttccgaatg atgggtttgg tgaacaaggc tagctgctac 1930681 aatatgcgga aaatgactga ttacgcttgt aacgccatca tgctcctctg gcgacatttc 1930741 cacaaaatgg gcattcgtcc ccttcagcag gttttttaac tgttccacag cttgtttgtc 1930801 cgttttctgg cctggcgtta aaatataaaa tgcattttca aacaggaact ccttcgcagc 1930861 ggccactcct gatttatgtg aacccgccat cggatgccct ccgacaaatt gatagcggct 1930921 aggcagcact tgatcagcgt aatcaaccac tttttgcttt gtgcttccta catccgtaat 1930981 caaaagctca tgttcaattc ctgaatgagc cagctcttca agcataacca gtgtttgttc 1931041 aacaggtgtc gcaatgatta ctgtagctgc ctctttcaca ccgctaataa acgaatcagc 1931101 acgatcgtct atcacgccta attttaatgc cgctaccgcc tgttcatcag agatgtcgat 1931161 tccgataatc cgtttgccgg gatgattttt tttgatggct agggcaatcg aaccgcctat 1931221 caatccgaga ccggcgagca atattgtatc tttcatttga ttcatacgtc atcacctggt 1931281 ttatagacta aagaggtgat atttgatcac ctcttataaa atttcagcta aaatggcaag 1931341 tatttcttca ttttgctctt ttgttccgat cgtaatccgg agtgatgtcg ggaaacctaa 1931401 tgcgtttcct gaccggacga tatagccttt ttccagcaga gcctgaaaca gttcatcagc 1931461 aggacgttta aagtcaatta acacaaaatt tgtctgtgaa gggtagcact ttaaaccatg 1931521 agttttcgca aaatcataat actgctgaag gcctgcatta ttttgctcga cacaggaagc 1931581 aataaacgct tgatcatcaa gtgctgcaat cgccgcagcc tggcccagac ggctggtatt 1931641 aaacggctct ctcgccggct caatctggcg aatcaggttc tcgtcagcaa ttccgtatcc 1931701 gactctgagc gctgccagac cgtatgcctt tgaaaatgtg cgcaaaatca tcaaattgga 1931761 atacttgctt aagagcggca cggtttccgg gtaatcctct gctgttacat attcataata 1931821 tgcttcgtca agaacgacaa ggacacgaga aggaacgcgc tccagaaatg cgagtaattc 1931881 tccttcagat gtataagtgc cagtcggatt attcgggctg catatccaaa cgacttgtgt 1931941 ctgttcgtcg atggcttcta acatggcgtc taaatcatgt gagccgtcgg gacgaagtgc 1932001 aatttcacgt acttcagcac cttcaataac cgcattatgt ttatattgcg gaaaagtggg 1932061 ggcagcagta accgtgtttg ttttatcgtt taaaaatgcc cggcagatga tctgtatgat 1932121 ttcatcagaa ccgttgccga aaataagtga tgtttcgctg acattgaggt gcttactgag 1932181 ccttgtccgc aaagcggcgc tatacccgtc cgggtaaagg gctagctgtt gaatctcatg 1932241 atgaagcgcc tcttttgcag cctctgaaca gccgtaagga ttctcgtttg aagcaagctt 1932301 cacaacttta tccaagccat attctgattt cactgcttca atcggctttc caggctgata 1932361 aggcttcagc tgttttaaat gttctttgat acgcaaatca gtcacctcat tttaaactgt 1932421 acaagccgct aaacgccatt gcataatcct caaactcctg cagcgcctga tttctcgttt 1932481 cagcgctgat gagccggtcc tttaattctt ctatttttct gacgagcgca cttcccacta 1932541 cgacaccgtc actaatttca ttcatcttta tgacctgttc acggtttgat ataccgaacc 1932601 ctacagcaac cggaacagtg ctgagattct tcacagtacg aatgaacggg tacacggatg 1932661 aattgaactc attgcggaca ccggtcacac ccagagaaga tacacagtag acgaacccct 1932721 cggcttgttc aataatggtt ttcaaacggc tttcgcttgt cggcgcaact aaagaaatat 1932781 acgtcacctc atggctttta cattcctctt gaaggctgtt gctttcttct aatggcagat 1932841 ccggaacaag cagaccgtca atatgatttt cccgcagtaa agcgaaaaag tattctttgt 1932901 tcaattgtaa cacaggatta taatacgtaa agaggataat cggaatattc actccgtttt 1932961 ttttcatttc tccgcctaat tcgattgcct ttacgatatt cattccttga tcaagcgccc 1933021 gctttgaagc ccgctggatc accggaccgt ctgcaagcgg gtcagagtat gcaacaccaa 1933081 gctccaatgc tgtggcgcct gctttttgga gtgacttcgc cagttcaatc gaaacctcag 1933141 gaactggatc gcccgccgta ataaacggga taaacaattt ttctgatggt tgaagatcca 1933201 atttaaacat gggctttcac ctcttcttcc aatacattca ttaatgtgtt gacatccttg 1933261 tctccccggc ctgataaaca gacgagaatg agttgaccgc gatccattcc tttggcgagt 1933321 ttgaatgctt tcgctaacgc atgggcagat tcgattgccg gcaaaatccc ctctttttct 1933381 gacaaaagct ttaatgcatc caccgcttct tcatcggtta tactgtcata agtgacacgg 1933441 ccgcttttat gcaaatatgc atgctccgga ccgattccag gatagtcgag accggctgaa 1933501 atagagtagg gctcaataat ttgcccgaac tcatcctgaa tgagataagt caatgaaccg 1933561 tgaataaccc ctacggttcc tttcgaaata gtggcggcat gaagaggtgt atcaattcct 1933621 tttcctgctg cttcagcgcc gatcagttca acatcttcat ttaaaaatgc ctgaaacata 1933681 cccatcgcat tgcttcctcc gcctacacat gccactactt tatcaggcat agtgccttca 1933741 atacgtttca actgatcctt cgcttcctct ccgatcattt tttgaaattc acggaccact 1933801 tgcggataag gatgcgggcc gacaactgat ccaatcatat aaaagtgatc ctcacaatgc 1933861 tgaacccagt accggatcgc ctcatttgtg gcatccttca atgttccgtt tccgcttgtt 1933921 acaggcacta cctccgctcc aagaagcttc atgcggaaaa cgttcagaga ctggcgggca 1933981 acatcctctt cacccataaa cacagtacag gaaaagccga atttggctgc aactgttgca 1934041 gcggcaacac catgctggcc ggcaccggtt tcagcaatga ttttcgtttt gcccattttt 1934101 ttagcaagca gcgcttgacc tagcgcatta ttgattttat gagaacctgt atggtttaaa 1934161 tcttctcgtt tcaaatagat tttcgcgccg cctaagtatt cagtgactcg atcagcgtat 1934221 gttaatgcag tcgggcgtcc ggaatagtcc tttaacagct tataatactc ttcacgaaaa 1934281 gcgggatcat ccttgatttg tttaaatgct gtttgtattt catctaacgg ctgcatgagt 1934341 gtttccggaa caaactttcc gccaaaatca ccgtatctgc ctatttcatt cggatatgga 1934401 tacatatcgg ttcatccttt cttctaaaag cctcatcaga ttctgatctt tttgtccgtt 1934461 tttttcaatt ccgctggcaa ggtcaattcc ttctggctgc catttcaata ggcgtgtgat 1934521 gctatccgga ttcacgccgc cagcgataaa gcagcgttta ccaatagccg cctgctgata 1934581 ttccggcaca cattcccaag aaaatgcaac accagttccg cctctagacc cttttacaga 1934641 tgaatcaatc acaaagccgt caacattatc tttaaagcgg gctatttctt gagttgtgtt 1934701 atcttgatgg tgaagcgcct tccatatttc acagcctgtc agcttgcgaa gagcagcagc 1934761 atccgccggt ttttcatcac cgtgaagctg aatgacgtcg agcttcaagc tcttggcaat 1934821 acgtgacatc gtctctattg attcattaac aaaaacacct gcaacctgtt tttcgacacg 1934881 aacttggttc agccattttt tcacatcttc cggagatact tttcgtttgc tttcagcaaa 1934941 aataaatcct aggtaatcag cctgtgattc cgccgcaagc tgcaaatcct ttagtgaccg 1935001 aataccgcaa tattttaatg ccggtttctt cacaacctca ctccctaaac aaagcatgga 1935061 ttgctttacg ctgagaagtt tgtctcatca atgattcacc gataagtaca gctcgtgctc 1935121 catgttcttt gacaaatgtt aaatgttcta aagaaccgat tccgctttcg ctgacaagca 1935181 gtgattcttt cggagcaaga gatgcgattt gttctgtctg catgatagag gtttcaaaag 1935241 tttttaggtt tcggttgttt atgccgagaa tatcaggcgt gaatactttc aatatttgtt 1935301 ctagcgttgt tgcatcatga acctccacta acacgtccat ctccttttca cctgcttcaa 1935361 gatataattc atgaaggtgt aagggatcaa gcacttcgcc gattaacaat atggcatccg 1935421 ctccgattct tcttgattcc tccacttgaa gagaatcaat aataaaatct tttctgagta 1935481 caggtatcga aacagcgcgc tttacgtctg ataaatagct gttttcccct tgaaaaaacg 1935541 gggtgtctgt taaaacggaa agcgcatctg ctttcgcagt ttcatagtct tttgcaatcc 1935601 gcacaggtac aaaattctct ttaataagcc cttttgacgg cgacgctttc ttcacttcag 1935661 caatcaaccc gataaaccga ttcaggcttg ccagcgcctc tttaaatgaa cgtttttcga 1935721 aaggctgctc taccggcaga accagtgttt tcacttcttc tttcttttgt ttgatgattt 1935781 tttcaagcat agatctcttc ctctttctgc tttagtcgtt caagctgcgc ggcagcgcct 1935841 ccgcttgtaa tcgtctctaa cgccagctcc gttccttcct tcagtgaggc ggtaattccc 1935901 gccgtgtaaa tcgcagcacc cgcattaaaa gccgtaatag ataaagcgga actgctgctt 1935961 ttattttcaa aaatattctg aatgagataa gcgctctctt tcggagactg cacctgtaaa 1936021 tcttcaagtc tgccatttgt gaaaccgaaa tcttcgggtg aaacggtata ctcccggcgc 1936081 tctccgtcct ttaattcaat cacgtcggtc ggtgctgtaa ttgaaagctc atctaaaccg 1936141 tcacggcttg atacaaacat aacgtgcttc ggctgaaacg tctccagtgc gcttgccatc 1936201 agtccagctt tttcaacaga atagacccca atcacctgac gcttcgcctg taaaggattg 1936261 ctgagcggcc caagcagatt aaataccgtt ctgaaaccta gctcttttct agtacctgct 1936321 acatgtttca tagacgaatg gtaaagcggc gcaaaaagaa atcccatgtt gtttgtttca 1936381 atgctgcttt tgaccttttc gggagtggtt tgaatagaaa cctctagctc ctctaaaaca 1936441 tcagcgcttc cgcttttaga agagacagag cgattgccat gcttagcgat tttcgcacca 1936501 gctgccgagg caacaattgc cgaggccgtt gagatattaa aagtggaaat accgtctccc 1936561 cctgttccgc atgtatcaac aatatcagga agtccatcga ctgtaagagc gtgtgcccgc 1936621 attgccttca caaaacccgc aagctcttct ggcgtctccc cccgatgagc aagaattgac 1936681 aatatccccc ccatttcaga aggagtcatt tccgctgcca tcatcatatt catcagcgtt 1936741 tcagcctcac cggcagtaag ggtttttccg tcaacgcaca attgtagaaa tctgttcatc 1936801 agctttatcc tccttgctat gaaacatgtc ttctgcaata tgaatcgttt tcagcagcgc 1936861 accggcttta ttacagcttt cttcgtattc ggcttccgga acagaatcag caacaatgcc 1936921 agcacctgcc tgtatcgatg caacaccgtt ctttacactc atcgtgcgaa tcgtaataca 1936981 agagtcgata ttcccgtcaa acccaatgta ggcaatacac cctccgtatg tctctctcgg 1937041 tgttggctcg agttcttgca aaagctgcat ggcacggatt ttgggtgcgc ctgttaaagt 1937101 ccccgccggg aaagcagaca tcagtgcatc gacaggatga accccttttt tcaatcggcc 1937161 tgtaaccacc gagataatgt gcatgacatg tgaaaaggaa acaatttttg tgaactccgg 1937221 cacagaaaca gaaccatact ctgctactct gccgatatcg tttcgggcaa gatcaacgag 1937281 catgtaatgc tccgcttttt ctttttcatc cttcatgagc tcaaccttca gtctctcatc 1937341 ttcagctttg tctgcaccgc gttttctcgt accggcaatc ggatggattt ctaagtgccc 1937401 gtcttgaacg tgtattaacc gttccggaga gctgccgact atttctctgt ctagcagttt 1937461 catataatac atatacggcg aaggattgac gatcctaagc actcggtata actcaaaagc 1937521 atctgctttt atcggcacct caaatttttg tgataaaaca ccctggaaga tatcgcctgc 1937581 ttttatatag cttttgattt tttctacatc agccataaaa gccgattttt cataattaga 1937641 agatactgtc tcaaagctgg gtgtcttgta tgaatcagca gaaagaaaca gctcttttat 1937701 gtttttttgg tccatcattt tttcaatgag attttgaagc tccagatgat tttgatggaa 1937761 tacatccatt ttttcgtttt ttgtttcctc tccagtgagc cttgcatatt ggataaagtg 1937821 gacgtttttg gtttcatgat catacgcaat taatgtccgg caaacaaaca gcatacactt 1937881 ttccatgtct gtttctttgg tatgcgaagg aacagaaggc tcaatcagcg ggatcatatc 1937941 atagcttaag tacccgacag ctccgccgac aaaaggaatg ccaagctcag gtgttttgat 1938001 tttgtatgtg gtattcatcc agttcagcac ttcttttagt tcatttcctg tgtaaagaga 1938061 tttgctgtcc tgatcagcgg ccgaaaaacg gccctgctct tctttaattg tgagaaatgg 1938121 attcaggccg ataaacgaat atctggacca agtggatgta tcgtccttgc tttcaagaag 1938181 atacgtaatc tccctgtcaa gcttctctat catttgaatg ggtgtcagtg tatcgactgt 1938241 gaaggtctcc acaatcggta tcgtgtggtg ggacaagctg tcctctaaaa atgcggaaat 1938301 gtttgattgg aaattcattg ctctcactcc ttatggcaag gagaatgaga agatggcatg 1938361 agaggataaa atactatata acaaataaac ccaaaagaaa gacttctttt gggtagaata 1938421 aacataatgt ctcagctcaa ctaaactcat tctctgctac cctattctct aactcaactc 1938481 attctaattg ctttatacac actcttgtgt atttctaagc tgttcttatc gtattacaat 1938541 tcagtatttt ttgtcaatga taaatcgggc ctcaatacga caactttttc taaatataca 1938601 tgtctgatct gatcctgagg gacatctgtc tggaccgtca tcatgactct tatgcacttt 1938661 ttcagaccgc ctgttacgtc catttcctgc atacatgtta ccggtacata ctgccatcct 1938721 gaaagctcgc gaacagcttt tgccgggaaa acagcgtgca aatcaggtgt agccgacaga 1938781 agcatttgaa caacatcttc cggttttgta tgattttctt ctatgatttt ctctaacagc 1938841 tgtttagttt tttgtaaaat ttcttcttca gtatcccgtt caactgtagt tgctccgcga 1938901 attccgcgaa tcatcatgat gtctcctcca atcgccattt gttcagccag ctctcaagtt 1938961 catttctgga aaatgtatga tcagcaactt tccctaattc gttgagcaca ataaactgaa 1939021 tcttcccgcc acgggttttc ttatcattca tcatacggtt caagagaacc gaagtttccg 1939081 tctcttttct gatttgactt ggataaccca ggctttttag ccagctgacc aaacgttttc 1939141 tgtccatttc acagcctaca gtcttttcgc ttatatataa agcaaactgc attccgaggg 1939201 ctacggcatc accgtgagtg atctgcccat atccatattc cgcctcaacg gcatggccga 1939261 gcgtatgccc aaagtttaag taagctctta tcccctcttc tttttcatcc tgctgaacga 1939321 cagacgcttt aattgaaatg cctttaaaaa tcatgtcatt cagctgatca ttagtgatat 1939381 cacgcagtga gtggatattc agcagctcct ccagaaacgc tctgtcatag ataaaagcgt 1939441 gtttaatcac ttctgccatt ccggacctaa gctctttttc aggcagagaa cgcaggaaat 1939501 ctgtatcata gagcacggct ttcggctgat aaaacgcacc gattagattt tttccaagcg 1939561 gatggttcac ggctactttt cctccgactg cgctgtcatg cgccaagagc gtcgtaggca 1939621 tttggatgaa atcaatgccg cgcataaaag tggcagccac aaaaccggca agatccccta 1939681 caacaccgcc accgaatgcg atgatgcatg aggagcgatc catatgaaaa cgaatcgctt 1939741 cactctgcaa ttttgtgtac atgtccatgg attttgcctg ctctccactc ggtaccgtca 1939801 cttttttcac aggccatttt tcttgcagca aatggagcat ttcatcacca tacaggcggt 1939861 ccacttcttc atccgtgaca aacataatcc ttgttaaagg cctgtttaaa gaggttaata 1939921 gttcgcaagc cttttttctg ataccttgtc cgataaaaac aggatatgac gaggaagcag 1939981 tttgaacatg cagtgtcttc attaaaattc cctcgacagt tttctcatat tctccacatt 1940041 ttctctaatg cggtcaattt gatctaatcc gaattgttca acgactgcgt tcgcaatttc 1940101 ccaagcgaca gccgcttcag cgactacact tgccgcagga acagcacagc tgtctgaacg 1940161 ttcaatgctg gcagaaaacg gttctttcgt ttcaatatcg acacttttca gcggtttata 1940221 caaagtcgga atcggcttca tgactccgcg gacaacaatc ggcatccctg tcgtcatgcc 1940281 gccttccagt ccgccaagtc tgttagtagc acgggtgtat cctttttcct cgtcccaaat 1940341 gatctcgtca tggacttcgc ttccatttcg ccctgctgcc tcaaatccga tgccgaattc 1940401 cacaccttta aatgcgttaa ttgacagaac agcggcagca agcttgctat ccagcttgcg 1940461 gtcataatgg acatagctgc ccacgcctac cggcattccc tcgacaatga cttctactat 1940521 tccgccgatg gaatctccgt ttgcctttgc ttcatcaatg gcagccatca tttttttgcc 1940581 tgcctcttca tcgtagcatc tgacaggaga ctcttccgtt acacgctgca agtcttcaat 1940641 tgacgtatac tctgtttttt cagctttaac agcgccaatt tgcaacacgt ggcccgccac 1940701 cttaatgcca agctcagaaa gaatcttttt agctacagcc cctgccgcca ctctgacagt 1940761 tgtttccctt gctgaagaac gctcaagcac atttctcata tcacgatgat tatatttaat 1940821 tgcaccgttt aagtcagcgt gcccaggtct cggtctggaa atctggcgct tcatttcctt 1940881 ttcttcatct tctgtaatcg gagcggcgcc catgattttt gtccaatgct tccaatcgtt 1940941 attttcaact acgagagcaa ttggcgaacc gagtgtacgt gcatggcgca ccccgctcat 1941001 aattttggcc tggtcttttt cgatctgcat gcggcggccg cggccgtgtc ctttttggcg 1941061 tctggcaagc tcaaaattga tatcttcctc cgttatgtaa agcccggcag gtacaccctc 1941121 aataatggtt gtcagttggg ggccgtgtga ttctccggct gttaaatatc tcatgacttc 1941181 ttctcccttc atcgcattaa cgcttttaag taagactact ataacatatt tttcagcaaa 1941241 aagtcagtct atcttttttg ataaaagaat gtatcggctg ggactaggcc aaatttctcg 1941301 ggattgaaga tttgctcggt gctgccgaca aaaagaactc cattcttctt caagctatgt 1941361 gccattttta aatacagctc ttccttcgcg ctttctgtaa aataaataaa tacattgcgg 1941421 cacacgatta agtcaaagtc ttgttcataa cgatccgcca gcaaattgtg ctttttgaat 1941481 gtaatattct ttttgatttc cgttttcact tcataacttc tatttgcgtt ttgcgtaaaa 1941541 taacgatctt tcacagatag cggcacttcc tgtaaagacc gctcctgata aacgcctttt 1941601 ttcgcttttt ccaatgcttt ttcatcaata tccgtcgcta aaatctgata gcccggaaga 1941661 cctttttgct ggtccaaaag catggcaagc gtgtatggct cctcccccgt tgagcaggcg 1941721 gcactccaaa tttttaaagg cctagaggtc ttgattaacg gcagaattgc agtctcaaga 1941781 acttcccatc ttttataatt acgataaaat tctgaaacat tgatcgtcat tctgtccaat 1941841 gtttcattta agagagcttg atccttttcc aatgccgcag caaagtcctt aaagctttgg 1941901 aacccctttt tctcataaag tgacgttagc cttctcttca tttgtgcttc tttatatagt 1941961 gttaaatcga ctccggttaa ttgtttccat ttcgttgtaa atacgctgta tgtatccatc 1942021 tctactctcc cagtctcgct gtctttttgt cctagtatag cttgttttat caggaaattg 1942081 tattgtttca ataaaaaaat cagcttttca gctgatttta gatcgttggg aaaggcagag 1942141 gtctgatgca cactgccatt caacccttta ttcactttaa tgtaaacctt tacaaaacag 1942201 aacaaaaacc ggcggcgtta tatgttgccg gctctgttgc ttattttcac aatgattaat 1942261 agatccagcc tgccataagc tgctgatatg atactaattc ttcattctta aagaaaatgt 1942321 taatctcgcg ttctgcactt tcgagagaat cagagccgtg gatgatgttt tttccgacaa 1942381 acatgccata atccccacga atcgtaccag gtaaagcttc tttagggttt gttttcccga 1942441 tcagctgtct cgtcacttca atgacatttt cgccttccca caccattgcg aatacaggtc 1942501 ctgaagtaat aaactcaacg agctctccga agaaaggctt accttgatgt tcggcgtagt 1942561 gtttctcagc catttgttca gtcactctca ttaacttggc gccagctaat tgtaagccct 1942621 tacgttcgaa tctagataaa atgtccccaa tgagctgacg ttggacaccg tctggtttca 1942681 ccatgataaa agtcttttcc atcatattct ccaccccatc attatgtatg tataggcttt 1942741 cacactgcac accgaaatcg taacatcttt ctgataatta atcaatccgg ggcggagaaa 1942801 tttcttaata tctacaaaaa ttaaaatttt cttttaccga tatattttgc gatggctgca 1942861 agagacgagc gtgcgcgccc tcgaggaagc gtgtttaatt tctgaaaagc tttctgcaga 1942921 tacatttcgc ttactgccat agatgcttca attgcatctg tttttttgat ttcttcaatg 1942981 attggttcaa gctgttcctg cgttgtctca ctgttaatca atttaagctg gttttttaat 1943041 gcaggatttt tcagggcata cagcactggc aatgtgacgt ttccttgaag caaatctcct 1943101 cctacgggtt tacccagctc ttcctcagtt gaagtaaaat caagaatatc atcaataatc 1943161 tgataagaca tgccgacgta atacccaaac cagtacaatg ccttatgaat cttctcatca 1943221 gctccagacg caatggcacc aagctggcag ctgaccgcga tcaagagagc tgtttttctt 1943281 ttgatacggc ggagatacgt tctgagattt tgttccatgt tgtatttgtc tttgatctgc 1943341 tcaatttccc ctagacaaac ttcaacgatc gtctgtgaca aaatcctatg ggctttcggt 1943401 tcgttaattc tcgtcatcat ttcaagagat cccgcaagca tataatcgcc tgtgtacatc 1943461 gcaatacgat tgtcccactt tgctttgatt gtcggttttc ctcggcgaag ctctgcatca 1943521 tcaatgacat catcatgaac caaagatgcc atgtgaatca tttccagagt gacggcgaca 1943581 tatttaatct tattaatatc ataatcgcca aacatgccag aaagcagcac gaaaacaggc 1943641 cgaatacgtt tccctccggc ctgcagcagg tgaagacctg cctcgcttaa aagcgggtaa 1943701 tcggaacgta cggtttgttc aagttctctt tcgattacat caatatcgtc atttaaaaaa 1943761 gagtaggcca ttttaaattt catatcattc acccaaacat ctgtgttttc atttccatcc 1943821 gatatgcgtg gcagcgactc cgccagtaaa cgaatgatat ttaacatttt tcaggcccgc 1943881 ctcttcaaac aggcctgcca gttccttcat tccagggaaa tctctggctg attcttgaag 1943941 ccaagaatat tctttatagc tcttcgcaaa cagtttcccg aaaaacggca taatatactt 1944001 aaagtacata aagtaagcct gtctgaatcc gaacatttcc ggctgggacg tttccagaca 1944061 taccacctgc ccgcccggct tcactacacg tctcatctct ttcagtacag tcaagtaatc 1944121 agggacattg cggagtccga agccaatggt gacataatca aatgtatcat catcaaaagg 1944181 aagctccatc gcatttccgt gcagcagttc aatttggctg aatccgccgt cttttacttt 1944241 ctgctcgccg acactcagca tattttcact gaaatccaag cccttgatct cgccgctttt 1944301 gcctgccgct tttgcaagag cgatcgtcca gtcagccgtt ccgcagcaga catcaagtgc 1944361 ttttgcgcct tcctttacat tcatgatgcg catcgttttg tcgcgccatt ttttatgctg 1944421 ctgaaaactg atgacagagt tcatttggtc ataattttta tatatttttt caaatactcc 1944481 gtgtacgcgc tgttcttttg agtcctgcat aatggtttac ccttcttcca ctttctgatg 1944541 ataggtttga tcttggctga ttgtcttcag acggtttatt aaaatgttct gaataggtga 1944601 atttagaggc agaagtgact caatgctgtt tttcgctttt ttaaaacaat cttctaatat 1944661 ctcttctttt gtttttccca gctgtataaa actgccgatc acatccagaa atgcatcatt 1944721 tccgttcata agccgcttaa atacaaaaaa atcactcgac agctttttcc agcgcgggag 1944781 gttgaagtgt tccgccacac gatggaataa agctgattca acgatgccga cactttcgaa 1944841 aaaatcgttt tcgtccttga aagaacggtc atacagacga attttatgtt cgttgatttc 1944901 tttaatggct gtagcaagcg tccgaatcat gtagatatcc ttcatttcag atagtaaaga 1944961 gtagtacagc ccgctgaaat aatcgcccgc gagaacagtc aattggcggt ttttgttttc 1945021 gtctcgtttt atgactctag ctgtcgtcac ttcatcatgg gtatcaaggg cgctttgtac 1945081 aagcatcgct gttacaatat aattttctct gtcgttgttt tttatgtcgg cttcttcaaa 1945141 taaagcatga aaaagaagaa gcttatcctc atcaattttc ggcgcagaaa tatgcttcgc 1945201 taaataagga tgagacagct tttgttttaa tttcgtgttc agattggcta aagttccgta 1945261 gatgtcttgc aaaaatatca cccttgtccc caaattcaca tttatttctt aatctatgta 1945321 tgagttttat cttttcattc gcttacgcag gtatcattat agcataaaaa aaagaaattg 1945381 gctgtatcct cccgctgttt gcgagcattt gcttttaaca gcggggacag ccagcttatt 1945441 ttttttcgct tttcatttct ccgtacgcgg tttgaatcag tgcctctcct ctgactttaa 1945501 tggcagaagt atgctctgta aactgagcga tgatcacttc tcccttgtcg agtttttcgg 1945561 aatggtgaaa ctttgtgtct gttcctcttg tcaggccgat cacattcact ccgtcctcaa 1945621 cggctttaat gacgacaaaa tcacttgaat gcttttggtt catttatagc accctctatc 1945681 tttattagtc ctggcgttta atatgttcca atacttctgc acgggcagcg gcatcatctt 1945741 taaaaacgcc tctgactgct gaagtcacag ttttcgcacc cggttttctt acaccgcgca 1945801 tcgtcatgca catgtgttcc gcttcaacca ctaccattac gccatgcgga tcaagcgttt 1945861 ctacgatgct ttctgcaatt gtagaagtga tgcgttcctg aagctgcggg cgctttgcaa 1945921 cggcttcaac ggcacgtgcc agtttgctga gtcctgtgac ctttccgcct cgcgggatat 1945981 atgcaacatg tgcttttcca taaaagggaa caaggtgatg ctcacacata gaatgaaacg 1946041 ctatatcttt tacaagaaca agctcctcat ggttttcacc gaagatagtc tggaaatgtt 1946101 cttttggatc ttcattcaag ccggagaata cttcggcata catctttgcg actcttttcg 1946161 gagtatcaag aagcccttct ctattcgggt cttctccgat cgcttctaaa atttgacgaa 1946221 cagcttgttc gatttgctct ttattaactt ctttcatgtt ctatgtcctc caccaatgaa 1946281 tacatttaat ttcgattcta gcacatatgc cccgctaaaa gcaaagtgaa tgccctgtca 1946341 ggaagcccat gctcttgaaa tatgaaaagc cccttagaaa ggggcttttc tgtgaagaaa 1946401 taaagtgtat gtaagctaga tgcatacacg atctatattc acaattattt tccggcaact 1946461 gcgtctttaa gcgctttacc tggtttgaaa gcaggtactt tgcttgctgg aatttcgatt 1946521 tcttcacctg tttgaggatt gcgtccttta cgtgcagaac gttcacgcac ctcgaagtta 1946581 ccaaaaccga tcagttggat tttatcaccg tttttaagtg catctaagat cgtatcaaaa 1946641 acagagtcaa ctgcttttgt agcgtctttt ttagacaatt cgcttgcttc tgcaaccgca 1946701 ttgataagtt ctgttttgtt catgcctttc acctcctccc aaaaggatac attcagttcg 1946761 tttattatca tttcttcaca gttcagtctg attctaaacc tgtctcagaa aaaaatgaga 1946821 gcaagtaaga gaaagacaat taaacggctt tttaagaaaa actgcactct gaggaatgtt 1946881 tgtccaacaa agtgaagaat ttctgtatgt agagtaacac atataaaaag ccatatcaag 1946941 cattttaaag cgtcaatccc ttgctcgtca aggatttaag gtgatttacc gaacgaatat 1947001 tccttttttt ccttttttca tcctattcct tgatcctttt ccattattaa gagcaaagaa 1947061 aaaagacctc ccattctata aagaggtcta ccggtattac aggatgatgg cgattaagcc 1947121 gccagagcct tcgtttatga ttctttctaa tgtttctttt aatttatacc gtgcgttttc 1947181 aggcatcaat gacagctttg cctgaatccc ttctctcaca attgagctca gcgaccttcc 1947241 gaagatatcg gaattccaga tggagagcgg atcatcctca aagtcctgca ttaaatagcg 1947301 tacaagctct tcactttgtt tttccgttcc gataatcggg gcgaattcgc tttcgacatc 1947361 tactttgatc atatggatcg acggagcgac agctttcagc ctcacaccga atcgcgagcc 1947421 ctgccttata atttccggct catcgagact catatcagct aaagcaggcg ctgcaatgcc 1947481 gtatcccgtc tgtttgacca tttttaaggc atcagacact tgatcatatt ctgttttcgc 1947541 atgggcgaag tcttgcatga gctcaagcag atggtctctt cctctgattt cgacgcccac 1947601 aacttctttt aggatttgat catatagatg atcaggcgcg tacaaatcaa tttctgccac 1947661 cccttggccc agctcaattc cggctaatcc ggcactttca atgaattcaa actcgctgaa 1947721 ttggccgaca accctgtcta cgtcccggag ccgtttaata tccttaaccg tttccttcac 1947781 ggactcctga tagctttcac gcaaccaatg gttttctttc agcaccatta cccagcttgg 1947841 gagattgaca ttcacttcta gcaccggaaa ctcgtagagg gcctctctga gcacactcag 1947901 cacatctgat tcccgcatgc tctctacact cattgccaat accgggatat catatttttc 1947961 gcttaaatcc tggcgcatgg cttccgtttc cgggtgatac ggcctgactg agttgatgac 1948021 cataataaaa ggtttgccaa cctctttcag ctcttcaatg actctttctt cagcctctat 1948081 atagtcactt ctggcgatat ctccaatggt gccgtctgtc gtaatgacaa ctccgatggt 1948141 cgagtgttct tgaatgactt ttcgtgtgcc gatttcagca gcctcatgaa atgggatcgg 1948201 ttcttcgtac caaggcgtat tgatcatccg cggcccgttt tcatcttcat atcctttagc 1948261 gccgggcact gtgtaaccta cacaatctac taatcttata ttcacatcga gtccgtctga 1948321 cacatgaaca gacatcgcct gattcggaac aaatttaggc tctgtagtca taatggtttt 1948381 gccggctgcg ctctgcggca gttcatcctg cgctcgggcc cggtctgctt cgttactgat 1948441 attcgggagc accacaagct ccataaattt tttaatgaac gtggattttc ctgtacggac 1948501 agcacctacg actcctaagt atatatcgcc tcctgttcgt tcagcgatat ccttgaaaat 1948561 atcgaccttt tccaagtgat cccctcccgg acttcctatc cttttcaatt ttattaagct 1948621 ctttcaatca aacacaggac actatatgtg tatgacgttg tcctatttga atatgacatc 1948681 tttagaaaat ttctcatcct caatctatta atataaaaaa acctttctcc ctatttgtat 1948741 gcaagggaga aaggttcatt cctttttcat atcattttct aaaaaaacag gttcctgttt 1948801 gtcatttacc gtatatttta cagaaaacgc ggggacaaag ggggtttcat gccaaatcat 1948861 atcctggatt tcagtcccgg gtttaaacgt ttttttgctt tttttgaggc aagaagccag 1948921 ctcagtccgg taatcggcat atatttctcc gtctccgtca atcataagcg gcaaggaatt 1948981 ccctgagatt gggcttgtca ctgtaagaga gctgccatcc ccaagcttct tctcatcgag 1949041 tgtaaataaa tcacgagata gcacatcctt gtaaggcgga tattgatgct cctgacgata 1949101 catttggatg cgcaatttca catcgcgaat tttttctgcc atctttagat caattaattt 1949161 aacagtcgga tcgttctcta cgtcaacaag cacgtattga tagtctcccc cgctttcaaa 1949221 tgccgtactt ggaggttcag ctatgtatct tggcgctaac cggttaaagt ctatcggata 1949281 tttttgatat agcggtgtcg acatatcttt ggtttgaata ggaagcagcc ctccatttgc 1949341 cttttgaaat tcatcaacag cagattgaac ctgctttagc tggtcttgat aaggaatggc 1949401 atgcacactg cttttccgtt catttggata taaacatccg gataaaaaca cgactgccgc 1949461 aaaaatgatt gcgcacttca gtttacccat acagcacttc cttttacagc tttattcatt 1949521 gacagggccg ctaaaaacca cgacaaacac aataattcca gatatgagca tacacatgta 1949581 tgcgaatgat gaaatcgcaa tcttcaaaaa acggttttgg cacttaaagc ggcttaaata 1949641 gatggaagct acagccagaa acatcagacc catggaccct agagcaaacc acattttcat 1949701 caatgccaga ttcaatgacg tgcgcctccc cgatatgtaa gatataagcg ttatattata 1949761 ttttaatata cagcgccgga aaagatcaac cagattttcc atccattgat agaacaaaaa 1949821 aactgaagca aagaggggga ccttcgcttc agtcaacttg actatattca cctgcacgtt 1949881 taagaaacac tctcttggac ttcgatgcta tagtatgcga cttggcatac agatgcatcc 1949941 tctattgcct aaatcggcaa aatgtttcag gagatcccaa gacttgggtg ttcttctgtt 1950001 tttcgggctt tcgttcaatt aagatatgcg attcaccatt tgattgacac ttttacttca 1950061 cttgattttc aaacgtattt accaaatcct ccatctcgtg ggttttccct ctcgccatta 1950121 aagattcaac agcggtttcc actttttgtc cgttgaatag gacctgatgg agagcttctg 1950181 taatcggcat tttaacatca tatttcttcg aaagctgata agccgctttc gtcgtgcgga 1950241 cgccttcgac taccattccc atctcttcaa gaacatcttc aagcttgtac ccttttccga 1950301 gcaaattgcc cgcacgccag tttctggaat gaacacttgt gcacgtcaca atcagatcgc 1950361 ctactcctgt caatccagag aacgtcaagg gatttccgcc cattttcgtt ccgagtctcg 1950421 cgatttcggc aagtccgcgt gtaatcaaag cagctttggc attgtcaccg taccctaaac 1950481 catctgtaat tcctgcagca agggcaataa tattttttaa agcccctccg atttcaactc 1950541 cgataatgtc aggatttgtg tacacccgaa aattgtgatt aataaataga tcctgcacct 1950601 cttctgctgc cctcatgctc tttgaagatg cagtaacagt tgtggggtgc cgcagcccta 1950661 cttcttccgc atgactcggg ccggaaagga caacgatatc ttttctgaca tcactcggga 1950721 gctcaatttc cataatttca gaaatgcgca gaagtgaatc tggctcaata cccttgctga 1950781 catgaacaaa gactgccttt ttcgttataa aagggacagc ctgtctcagc acttcccgaa 1950841 ttgcttttgt cgggaccgca acgataatga catctgcgtc tgaaacagcc tctttcatat 1950901 ctgttgttcc tttaatggat gtagacagct taacattcgg caaataatct ttgttttcat 1950961 gcaactcatt aatttgatga attaaatctg cacggtgagc ccacacacac acttcatttc 1951021 cattatcagt tagaactaaa gccagtgctg ttccccaact ccccgctcca agcattgtga 1951081 cttttttcat gtttgattca caccttttta ttttctagct cttgcaaata ttttgattgg 1951141 tgtcccctca aaaccgaacg cgtctctgat tcggttttct aaaaaccgtt cgtatgaaaa 1951201 atgcatcagt tccggatcgt ttacaaacac aacgaagctt ggcggcttta ccgacacttg 1951261 agtcgcatag taaattttca aacgagaacc gttatgagtc ggtgtcggat tcattgccac 1951321 agcgtccatg atgacatcat ttaagacgtt tgtttgaact cgaagtgaat gattttcact 1951381 agctttgata atcgcaggca tcagagtatg gatccgtttt ttcgttaagg cagacataaa 1951441 taggattggc gcataatcca gaaattgaaa atgatcgcga atattttctt caaattcttt 1951501 catcgtgctc tcatctttgt caacagcatc ccatttgttt acgacgatga cgacggcctt 1951561 gcccgcttcg tgtgcataac cggcgatacg cttgtcctgt tcaataatgc cttcttcgcc 1951621 atccagcaca accgccacga cttctgagcg gtcaatcgct tttagcgccc gcagtacact 1951681 atacttctca gtcgtttcat agactttccc tttttttcgc atacctgcag tatcgacaat 1951741 gacaaactcc tgctggttgt aagtaaatga cgtatcaaca gcatctcttg tcgttccagc 1951801 cacgttgctg acaataacgc gttcttcgcc gagcatcgca ttcacaagtg aagactttcc 1951861 gacatttgga cgtccgatca gacagaattg aataacttct tcattgtatt tcgtttcagg 1951921 aatgttttta aaatgctctg caacggcatc cagtaaatca cccagtccga gtccgtgtgt 1951981 tcccgaaatt ggatacggct cgccaaagcc tagcgaataa aaatcataaa tattcgctct 1952041 catttctgtg ttatccagtt tattaaccgc taaaacaaca ggcttttttg tgcggtacaa 1952101 aattttcgcc acttcttcat cagcagctgt cacgccttca cggccgttca ccataaaaat 1952161 aatcacgtcc gcttcatcca tggcgatttc agcttgctgg cgaatctgcg ctaaaaacgg 1952221 ctcatcaccg atatcaatac cgcccgtatc aatcaaatta aaatcataat tcagccattc 1952281 agccgagctg tatatccgat cccttgtcac gccaggggta tcttctacta ttgaaattct 1952341 ttctcccgca atccggttaa agattgtgga ttttcctaca tttggtctcc cgacaatggc 1952401 tacgacaggt ttacccatag tacccttcct ttcaatccag ccgctttcat ttttacataa 1952461 attttcaacc ggttattaaa atcatttcat tcacttttat gaaaagaaac ccttcagagg 1952521 aagggcttaa ctcatttatt atatcagttt ttactgggat cacaactatt cttaaaaatg 1952581 tttcacgatc aaatacacgt catctccgat tctgtgagct attccatcaa ggatcgcctc 1952641 aagattttta gcgaaaagct ccatctcctt ttggtcattg caaaaaaaga caggtgctcc 1952701 ccctgcaacc cgatttcgat ttgtcgtgat tacagacaaa atcactttcg taagagattc 1952761 actcatccta tcaccttatc ctgattcttg ataaattcag tcggcattct aatcgcattt 1952821 tccagggttg gaacattgct aataatttga acagccgttt cgggatggtg aatttgcggg 1952881 agaacaaata ctgccactct cccatcattt aaatcccgtt ttgcaattgg tgtcaaagat 1952941 ggctctcctg aatcccgata aaccccgagc acattggaaa catcaaataa aatggcctga 1953001 cgctgcccta aatttgctat cgtcgctgct gaattaaagt ttttcggcgt caaaataaag 1953061 cccatgccat gctttaaaat cagttcctgt ttctctggaa gcccgatatt catcatataa 1953121 atattatcaa caaacagtcc cggaccgtca aagcgcggct ttatgtactc gatatctaca 1953181 atatccttca acacactgcc cgacataaac ttcatggcca gtaaaaaaca aacgacagcc 1953241 gctatgactg cagcccagat ggataaaaac acatacgcag aggttgtcaa aagcgctgta 1953301 aagatcacaa tataatttct gctttcaaac gcaatggcaa tcccctcaat atatgtgctt 1953361 ccccttgaga caagttcata cgaatccatt tgcgtcaatg tgttccgctc catgtttcgg 1953421 acatctctaa attgcgtcgc tgccaatgtt aaaaatgtga tggccgtaaa ttcctcctgc 1953481 aaaagcgccg gcataataat tgcacctaaa ccagccgcta tcaaccccag tgcgatgtga 1953541 atcactttcc catgaacata ggtcggatac tggcggtaat ccgttttcag catataaagc 1953601 cttgtcgcaa ttccggcaat gaccccagca ataatcggat agatgtaatc actcatgaca 1953661 ttttggtagc tcctttgttt gatcttttgc ttttctgacc aatctggctt gcgaggtgtt 1953721 cgtatttaga tatgccaaac agcaatatca tccccgcaga acacgcattc agccattgaa 1953781 agccgccgac agccatagcc ccggccaact tctggatcac aaatgaatac accagttcgc 1953841 cttggcacat ccctaggaca aataagacaa gctgcttctc aaaattcctt tcaacagaag 1953901 ctgttaaaag cactattaat ataacagcag cccactcagg ttttatgatg aaccaaaccg 1953961 ggtcatataa tgcaaaaaga taaacaaacg catacgcggc aacaagcgtc agatagacca 1954021 tgatgtaacg aaaacgatac attcccaaat acccggcata gacacatccg caaacgaaaa 1954081 acatcaaata tgcagcattc agggaaaaat ataaagcgat gtcatgtatg cttagaataa 1954141 tattagttaa aataaagaca gagacggcaa ttcgtctttt cgtcttttca aaaataaatg 1954201 ttgtcagaac ccacagaaac cacattgacc aatagtaata aaattgttcc attttacttc 1954261 ctccatattc ccagtatgga gttcaagcac attttttaaa caatcgatct cacattaagg 1954321 agtatgatca tgggaaaaga cagacaagag aaaaaactca aagcttcagg cagagtcgaa 1954381 tcagatcgcg accagtccat tcactatgac ggagcgacaa gccttgaaca aaacggaaga 1954441 ttcaaaaagc gaaaatcata atacaaaaag cccaaaccac atatggtttt gggcttttat 1954501 catttatcgc acactatagc ttgatgtatt gacccctctc tctgtgagcc aatgatgggt 1954561 ttcacctttg atcacaaggg gcgccttttg taaatcggca attgttctgg cacccagcac 1954621 ggtcataatc aactttaatt cctcaaggat cagctgaatc tcctcaagca gtccttcctc 1954681 accgctgtca gtcagcgctt ttaaaaaatg ccctgccatt ccggtgcaag aggcccccag 1954741 cgcaattgcc tttgccacgt caagcgcatc ttgcagaccg ccagaggcga tcatggtgct 1954801 tgcaggaaac tcagagcgga tttccgccaa acttgcagct gtcgaaatgc cccacgaatt 1954861 aaaaaaggag atttgccgct gtcttcggag attttcgatt ttcgagaaat ttgttccccc 1954921 gtaaccgcca atgtcaacag ctgcagcacc agcttcatac agctttcctg ctgatgcttt 1954981 gctcataccg aagccgactt ctttcacaat gaccggtaca ctgacccggc tgcaaatttg 1955041 ttcaatgcgt ttcaatgcgc cgctaaagct tctgtcccct tcaggcatca caatttcctg 1955101 aatcacattg aggtggatct gcagtgcgtt tgctccaatc atctcaacgg cttcctttgc 1955161 ctgagcagcc gttgcctcgc ttcccaggtt ggcaaaaatc agcccgtttg ggttttcctt 1955221 tcgaacaatt tcataggaaa gacgctctga tggatctttt aatgctgaca tttgcgatcc 1955281 cacagcaagg ggaattccag cctgagaagc cgctcgcgca agcgatttat taatctcata 1955341 tgtaagtttt ccgccgccgc cagtcattgc attgataaaa atcggcgaac tgcttgaaag 1955401 ttcgccgatt tttgtggaaa tatctacttg ttctaatgca agatcgggca gactgacgtg 1955461 aacaaacgta atatcatcaa gacctgtttc ccgcttctgg ccgatggaca aggcatgatt 1955521 gatgtgttgt ctttttcgtt ctgctcgagt cacgtttatc accaattatt ttagtttatt 1955581 cagcttatct ccgatcagat ctccaagctg gaagccagtg cttgtttctt ccttcgcttg 1955641 atattgacgg taatcttcct ggtcagcttt aggcgtttct tcaagttcac gcatgcttaa 1955701 tgaaatgcgc tcctcatttt cattcacatc aagaaccttc acttttacag tctgtccttc 1955761 ttcaaggact tcatgcggcg tgccgatgtg tttattggaa atttgagaaa tatgaacgag 1955821 accttcaaca cctggaagga tttcaacaaa ggcaccgaag cttacaagac gctgtacagt 1955881 tccttcaagc acatcgccag gcttcacttt ttcgccgatt tggttccaag gtccaggcag 1955941 tgtatctttg atcgataaag aaatacgttc attatcacgg tcaaccgata acactttcac 1956001 ttttacttct tgtccctctt caacaacgtc agacggcttc tctacatgag agtgggaaag 1956061 ctgtgaaatg tgtacaagtc cgtcgatgcc gccaatatca acaaacgcgc caaagtcagt 1956121 caggcgctgt actttgccat caagtacact tccaacttca agagactgaa gaagttcttg 1956181 ttttttattc gcttgttcac tttcaacaac agcacggtgt gaaaggatca cgcggttttt 1956241 atcacggtca agctctacaa cgagcagtga cagtgttttt cctttatagt cagtgaagtc 1956301 ttcaacgaaa tgtgcttcaa caagtgatgc cggaataaaa ccgcgaacgc cgatatcaac 1956361 gacaaggccg cctttcacga catctttcac ttcagcttca aacacttctt ttgtttcaaa 1956421 ttttttctca aggtcttccc aagcgcggtc tgcatcaaca gcacgtttag ataaaatcaa 1956481 agcatcgtct tccacttttg ttactttcag gtcaagctcg tcgtctactt taacaacatc 1956541 cgatgctttc tctacatgaa gacttgataa ttcactgatt ggaataatac cggattgttt 1956601 gacattgata atttctacat ctacatgttt gtcttctacc tttgtcacaa tccctttaac 1956661 tacatctcca acctctggca cttgaacatc aatttgattc atttcctctg tcatttgaat 1956721 aacctccttg gtccaaacct acacagctta attaaaacgg tttgaaagct gaacatataa 1956781 catgcccgct tttagccgaa tatgtattaa agaatcatcc aaaaaagttt tttgaatgat 1956841 caataaaaag ttttattagt attaacttct aataaaagga caggtttgtc aagcaataac 1956901 attctatctt cgttgaaaaa ttcaaaaaaa gtggcatttg ccatcctcag cgggactttt 1956961 gctccacagc ctcgaggatt ttatcagcta cctcttgaat ggaaagcgat gtcgtgtcga 1957021 tttcaagagc gtcttctgct ttacgcagcg gagatacttc gcgctctgaa tcaagcttgt 1957081 ctcttcttgc aatttcctca attaatgttt cgtagttgac atcaaagcct tttttcacat 1957141 tttcttcata acggcgtttc gctctctctt ccacagatgc caaaagaaag atttttactt 1957201 ctgcatttgg cagcacatgc gtcccgatgt cacgaccatc catgacgacg ccgccttttt 1957261 ccccaagctg ctgctggcgt ttcaccattt cttctctgac acttctgtgc ttggccgcaa 1957321 ttgaaacttg gttgctgatt tcatctgttc tgatcgcctc agttacatcg gtgccgttta 1957381 caaacacttt ttgtccatct tttgttgtaa tcagctcaat gtctgtccgc tttagcagct 1957441 cagccagttt ttcttcatct gtcagatcaa cgttttcctg taaagccgcg tacgtaatcg 1957501 cccgatacat cgctcctgta tcaatatata tgtacgattt tttctcagcc acaattttgg 1957561 caacggtgct tttccccgca gctgccgggc cgtcgattgc aatcgataat ttcttttcca 1957621 taattcctct ccttgctctt ttctcctcta aggattgtat cacgaacttt atgaaaaagg 1957681 gtgaaaaatt gatgaataat taatgtttga aggtttcaat cctattgttt tcctccattt 1957741 tatccacccc ttcatattga atcacttttg atacgtatgg ttcaatatgc tgatagtgaa 1957801 aaagaaattg gacaccaagt aaaatgatgg cctgaatgaa caataatttg atcagcagcc 1957861 gttcaaatgt tttcattgga gcacctccat tacaaatagt atggaagtgt ttgccgatgt 1957921 ttattccatt cgggcctttc ttctcttatt taactggcgc ctgatgcagt attgaagcaa 1957981 agcctgctgg tcacctgctg caatttctga atactctaaa gtcatttttc gtttttctga 1958041 cttggggtca ttaaagattc gtctgacaac tgcttctgtt tctatttgac gtgtgtgctc 1958101 ctcttcagga agacggatga tcaggcgcaa tgattccccc gattgaaaag aaaggccatc 1958161 agctaaaacc acggcgatgc cgcctgcact gatgttatag gatagtgtgc ggatctcttc 1958221 ttcatttccc ggctgaattt gcacatctaa taccgcatca gttcttacat attggcggcg 1958281 ctggattctt ttcatttttt cacggggagg catttcaaga cagatcattt gaagtttgtc 1958341 cttcacttta ccttttatac ggcttataaa gcgataagga acttcgtctt ttcccacaaa 1958401 ctctaccgtt acttccatat cgttatgtaa aatcacagtt cgccctgtaa ctacatcaac 1958461 aggatacgcg atcaaaagtt cattgttttc gatgctgacc gccttgcttt ttgccttttt 1958521 caattcattt tcttctatat attctaaaag tacattttct ccaatctcta tcattgactt 1958581 cactctttcg cattcaatat actcacgttt ttattaaagc acgtaatgaa aaaaaggaaa 1958641 agacatttag tcctttcctc ctgtttttat aggtctttat atataggttc tgcatttttt 1958701 agtttttcaa ccttttcttc cgatccgtct ttggcattga tatacattct gaatgtgtca 1958761 ttttcaattg tcccaagcat ttcgtagcat aacacttctt gacctagttc atttgtaatc 1958821 aaagcgagcc ttgtttctct cacttgtaca tttttattta atttagactt tgcctctgct 1958881 tcagtaattg caggcttagg tatggttctt tttctgtgag atgtgaggaa gtctcttgct 1958941 gaaaagccga caacctcacc gtcatccaag gccactttca tacgaattgc ctcggggtac 1959001 atccggactt tattttcaac aggaacatat gaaaatacac cgattttatc atattgggca 1959061 ctttcatcaa tttccaaatc atctgtttca aatccgtttt tctttaaaaa tgcaagcgct 1959121 cggttcgatc cgtcatttaa actgattttc tgatctttca cttctctgtt ttggatcaag 1959181 tataccggat gcccgccctt cttcgtaata tccatataaa tcactgcttt atggtctggg 1959241 tctttcatgc tgatgctata tacatcgcga tttgtttttt ttccgctctt taccacttta 1959301 attgaataat tgtcatctgg ggcaaagcgc tcagcaattt gttttgcttc ctgttcggaa 1959361 atttgttttc ccttcagatg gctgaagcct ttctcttctt ttttcgtact ggtgaaactc 1959421 gggccaagat cagtgccagt ggagaatgca ccaacatttt tttcgactgt tttaaagctg 1959481 ttgataatcg tattatcact ttgtttttcg tcagaagcca gagccatttc tacgtccatc 1959541 cagcgaaggt ttttgctcat gacaaggtgc tgaacatgac gcaattcatt ttgtatatct 1959601 tcggactgct gatatagctt atttagtgat gtatactcgt ttttatcaag cggcttttgg 1959661 tccaaatctc tgactgacgt tttatagctg aaatcgccga tctttgataa tagctcttca 1959721 gttttattaa acggcattaa tgtaagcggc agctgactga cgctgttatg agcttctgat 1959781 gtaatcctcc acacatcgat caatgcaggc gacagtgatt tttggctgtt catggcaagt 1959841 gttgttccga ttttatcatg aagctgatcc acctgatagg taagctcatg aaacgcccgc 1959901 tgatagttat tttcagcatg aagaagaact gcgtcttttt cctggtgttc tttgtatccc 1959961 cagtagcctg taccgactat tgcaatacca agcacggcga ttaaaattcc tctgatcatt 1960021 tatcacacct ctttttatgc tttctcatat ctgctactca cagaaaatgt gtttaccgat 1960081 tcttttaatc tgcggacgcc cccaaatcca cggacttgta gccgtatccg gattaaagta 1960141 gtaaagtgct tcctctgatg ggtcccagcc attgatggca tccagcactg cttctcgtgc 1960201 cgtttcattc ggctgcatgt aaatttgtcc gtcggctact gctgtgaagg caagcggctc 1960261 aaaaataacc cccgctactg aatttggaaa taacgggctg ttcaaacggt ttaaaatgac 1960321 tgctgcaata gcaacctgcc cctcgtacgg ctcgccccgg gcttcgccat aaaccgcttg 1960381 agcaagcagc ctgatatcgt tgttggaaaa tccaccaggc atgttcgctg ctaccgcatc 1960441 ctgttttctt gcttttgctg gtgtattgtt ttgctgttta ttcgcattcg ctttaggctt 1960501 ctgcgttgtt ttttccgcag gctgtttctg ccgtgcttct gcttgttgtc ttgccttttg 1960561 tgttgctgct tttgatggtt tcgtctgata ctttagcgga atttttccgt aatgcgtgaa 1960621 tgtattccct ttattgagct gttccatgac atattcacga tagtattttg atttacatat 1960681 taaggtttgc tttgttttag ctcctacaag gccgtcaacc tcttttaacc cgaattgatc 1960741 ctgaaaattt cgaactgccc agtacgtccc ccatccataa accccgtcaa tttttccgtt 1960801 ataatatccg ttgtattgaa gacgcgcctg aagctcgacc acatcatccc ctgttgcccc 1960861 tctttgaatg acctgattcg aaaaggcaga gatcgtttca gtattaataa acgtcgttat 1960921 tgtaaaggaa aaaaggatga gacatgccat aatcgatcct ttggacttca tcttttcaag 1960981 cctcctactg caaattttta agtgtaatcg tattttctgt aacgaggtta tttttataca 1961041 ctctttcctt gttatccctc agaacataaa aactgcacac aaaaaagccg cacggttgct 1961101 gtgcggcttc tatacttgca tcatattaac ggaacgggct tttttcgctt tacgcaaacc 1961161 aaaccaccat aaaaatacca taaatggaag catataataa atccaattgc taagcgctgt 1961221 taggataaaa tcatatgatc catgcaaaag ggatgggaca actaaagaaa gagtaagcca 1961281 ctttacacgc gccttatcag cggaaaaacg ggcttttcca aggtaaaatc ccattataac 1961341 gccaatcaag gcatggcatg aaacaggcag cagcgccctg acaaacgcat gctccacgcc 1961401 gtggccaatt aaataaagaa tattttcgag ggttgcaaaa ccgagtgata cacttgcacc 1961461 gtacacaatc ccgtcataat gctcatcaaa gtgggcgtgc gggtaaacac tgatcatcag 1961521 tataaaccat tttaatgatt cctccaaaaa ccccgaagat aaaaaagaaa cgaaaaagct 1961581 tccgcctcct acattctctt tttcaagtac atactggata aacatgatgg gaaatacaag 1961641 aacaaccccg agaaaaaacg accgtagcac catatgtaca ggttcattat catactgatc 1961701 ttttaaataa aaataactta ataacgcgat gccgggggca attcctgcag agatgattgc 1961761 aaacatcagg caacctcttt cctttatatt cctacatcta tcctaccatg ttgtttaaaa 1961821 ttttacatct gtctgcactt aaaaaaacaa aaagagcata cgaatgcatc atatgctcct 1961881 catctttaat ggttttctct tttggcgatt tccgctgcga tatgcccccc gtgaaacctg 1961941 ccgttttcaa taaatatttc atttgcattg tttcccgcag caataacacc ggcaataaag 1962001 acaccttcaa cgttcgtttc catcgtttct tcgttgaaaa atggacgccc tgtttcttta 1962061 tcaatttcaa caccaatttt ttcaagaaat tgatgatcgg gatgatagcc tgtcatggca 1962121 aatacaaaat catttttaat ggtaatgagt tctttctctc cggagcgaaa cacaacttca 1962181 ttctcggtga ttttttcgac acaagctcca aattccatac ggattgtacc gtttctgacg 1962241 agagcttcaa attccggcag aatccacggc ttaatgctcg gagaatactc attgccccta 1962301 tataaaactg tgacacgcgc cccagatttc acgagttcaa gggcggcgtc cacgcttgaa 1962361 tttttcccgc cgatgacaac aacatcttta tcaaaatacg ggtggccttc tttaaaataa 1962421 tgaaatactt tcggcaaatc ctcaccgggt acgcccatat agtttggatg atcataatag 1962481 cctgtggcga tgatacaata tggcgtcgtg taggtctctt ttgacgtctc aataacgaat 1962541 gtgttatttt gcgttttcgt cactttacgc accatttcaa acgcattaac acggatgttt 1962601 ttccgtttaa cgacttcccg gtaatacgat aaagcctgaa ttctgacagg cttcctgttc 1962661 tctgtaataa atgccacatc tccgatttcg agcttttcac ttgaactgaa aaaggtttga 1962721 tgcgtcgggt aattgtaaat actgttaacg acattgcctt tttcgatgac gagggcatca 1962781 atgccaattt gttttaggtg aatggcagca gatagtccac aaggtcctcc gcctataata 1962841 attgcttttt cttgaatcat ttctgtcaac tcctgcgatt ggcatttcac ttcatatttt 1962901 ctatttccga ataaaaaaat ctcctatttt atcataggag attttttatt tttatgcaaa 1962961 tcatcaactt atatccagcc tctaaaacgc gaagcttcag ccattttgcg aacgccgacc 1963021 atatatgcag cgagcctcat gtcaattctt cggttgttag ccatttcgta aatattgtta 1963081 aatgatttga ccatcatttt ttctaatttt tcttctacct cttcttcact ccagtagaag 1963141 ccttggttat tctgaaccca ttcaaaataa gaaactgtta cgccaccggc acttgccagc 1963201 acgtctggta caagcagaat gtcccggtct gaaagaattt ttgttccttc aagcgttgtt 1963261 ggtccgttcg ctgcttcaac gacaatttta gcccggatat tatgggcatt ttcttctgta 1963321 atttgatttt caatcgcagc aggaacgaga atatcacaat ccagctccag cagctcttgg 1963381 ttggtaatgg tatcgttgaa aagctttgtt acggtaccga agctgtcgcg tcggtcgagt 1963441 aaataatcga tatcaaggcc ttccggatca taaagtccgc catacgcatc tgagatgccg 1963501 acaacttttg cccccgcatc atgcataaat tttgccaaat agcttcccgc gtttccgaag 1963561 ccttggacaa cgacacgcgc acctttaata tcgatgcctc tcttcttagc cgcttcttta 1963621 atacagatgg taacaccttt tgctgtcgca gattctctcc cgtgagatcc gccaagcaca 1963681 agcggtttgc ctgtaataaa tccaggcgaa ttaaattcat caattcttga atactcatcc 1963741 atcatccaag ccatgatttg tgagtttgta aatacatccg gtgccggcac gtcttttgtc 1963801 gggccgacaa tttggctgat cgctctgaca taccctctgc tcagacgctc cagctctcta 1963861 aacgacatat cccttggatc acaaacaatt ccgcctttac caccgccata tggaagatca 1963921 attatgccgc attttaaact catccaaatt gaaagcgcct tcaccgcctt cacctctttt 1963981 tctgttacgt tcgggtgaaa acgtatcccg cctttcgttg gaccgacaga gtcattgtgc 1964041 tgcgcacgat atcctgtgaa aatctttact gaaccgtcgt ccatacgaac aggtattttt 1964101 accgttaata atctcatcgg ctcttttaac aattcgtata cctcttcggg atatcccaat 1964161 ttttccagag ccttatgtat tacggtttgg gttgatttta atacatcaag tttgtcctct 1964221 tctgtatgac cggtgtttcg atcggctgcc atttgagtta acctcctaga atcttctgtt 1964281 tctcacatgc tccctttcag agaatagtat acaccttcat atgatctgtg catagaataa 1964341 acgttatgtt tttccatgtt ttttaacgaa aaaaaactgc tgaaatcagc agttttccgt 1964401 tgcattctta tgaaaaatga gtttgtatcg tttctacggc attaccgtcc ataatgagct 1964461 taccatactc ttgcaggcga taaatcgtta aagttgtcgg attgccgtat tcagccagaa 1964521 ccgccacaac cccttcagcc gtatgtgacc ctagatcttc aaggcttaaa aagtactgcc 1964581 cgtcatagtg gtagacagtt ccccctgtga taccgattcg ctgtaagctt tctgaaagct 1964641 gaatgatatc ttcaaaggaa tggaattgat atatgatgtc cgcgctttca tcaagcttga 1964701 cttgcatttc gatgtaatca tcatcatact catcgtcttc tgaatcggcg tcttggttct 1964761 ttgttacaat cacgaccatc ccttgtgctt ggagagaata cacttccact gcaatcggtc 1964821 cattcgcttc aaagccgagc tctgtatttg cttcattcat catatcttta aataactggt 1964881 ggactttaaa tgagtccttc cagaggtctt cttttgtcaa tccccggtct gtcaaatcat 1964941 cgagggttaa aaagattttg atcttattat aattcagacg ctcaagccgc ataacgttcc 1965001 ctcctgcctc tacttgcaca caaatcatat aacacattat atgagatgat gagtcatagg 1965061 ttcttaattg ttatcagttt acactgagtt cactagtaag acaagcacaa tgcagttttt 1965121 attgccatac ggatttttgc tttttagaag ttattctggc ccgcaaagag tcacaatgtg 1965181 agtttcaggc tcagcaccta aacgaagagg cacttttgtc gtgccgtagc cgttgctgat 1965241 cagatatgcc gcgtttttaa caatacctgt tttccccagt tcataaggac cgaattttcc 1965301 aaacctgatc tggcctccat gggtatgtcc gctgagtatc acatcaatac cgtcatcttc 1965361 attgatttgt tcatgaatct ccggattatg gcaaaccaga atattcagct ggctttcatc 1965421 aagttctttg atggcttcct cataatgatc catctccatc ctgatatcat caacccccgc 1965481 aatcgcaatc gtatgcccat tgtatgaaaa cgggactgac tcatttctca gagtgatgac 1965541 gccgtgcgct ttaaatatgg aatacagctt atgctgcctg acttcataat cattattccc 1965601 ccacacaaac acgataggga ccccgaaatg tacgagcctt ttgatgtttt cctcgattct 1965661 cgcactgggc accccgccct cagctaaatc accgccgatt ataaccaagt ggggggcatg 1965721 gcttcgcgct ttttctaaaa ggtcttgatc gatgagacgt ttgtgaatgt ctgaaataaa 1965781 aaagattgtc agaggcggct tgcccttcat ctttgataaa ggaaacgtat gtgtcttcaa 1965841 atgattgcct tttgctgttg catacatttt tgccgtcatt gccgctgccg caacagttag 1965901 tacaccggca attttcactg atagcttcat aaaaaactct ccattctttt tagaacttat 1965961 caataagacg gacaataaaa aaagacgttt ctatcgtttg agaaaacgcc ccattttatt 1966021 tactttcaaa atatagatta atgtcatatt tgtgcttcat catatgaaaa acagactctc 1966081 tcgccttcca tttatcgggc tgcggccaga gatcagtgct tttctgaata atttcacatc 1966141 tcagtttatg gaaatcagtc tcggattttt cttccttttt cttgaaataa tatgaagtgc 1966201 agtaggcaaa agcggttgcc agcatccaaa ataaataaaa ggtatggcta agtatttctt 1966261 gaagtataag ctgaggctcc gggcttttga tcatgatcat aacacataat aagcctaggc 1966321 agataagtga agcccatcgc catctgcggc attgtgctgc ataattttcg aatttttgtt 1966381 ttcgttttac cagcgcttgg agcatctgtt tggtcggcgc gtctgtaaac tgatccagct 1966441 gattccataa ggattccata cgcttcacac cttgtccatt ttcattgcta caatatatga 1966501 acgtaaaata aaaataatac cctattcatc cattaaaggg atgtccaaaa cttgtccggt 1966561 gtaaacatca tttccattca gatgattata tgctcgaatt ttttcttctc ctgtccggct 1966621 tttataatac ttcatggaaa tgcggtatag cgtttctttc ttttggacgg tgtgcttgac 1966681 aacgcgattc ggcacatttt gaactggctc agctggctgt tcttgctgtt gtactgttga 1966741 ttgggaagag gaagcagccg cggcggttgc ttcctcctta tttggcgagt cttctttttc 1966801 cgctacagca gtctgtttct tatcagcagc tgtttgctct tttggcttgg aatcttctgg 1966861 ctcttttttt gactccttct gcagtgcggt ttctttagtg tctgcggtat cgtttttatc 1966921 ctctgatttc gggacaacct catatttgct ttggctgctg tcaataaaaa catcttcata 1966981 atcgtcatga ttatccgggt ggctctttag ataaaataag gtgactaaaa cgataaccgg 1967041 cacaaataca aatattactg cgagtactgt gaataatggc gtttttgttt tgccttgctt 1967101 ttttttctgt tctctttgat tttttacaga ttgtcttgtc ggaaggcttt ctccatcatc 1967161 gacataatcg tccgccaatg cggcgttttg atcttcataa agattctggg cttttcttct 1967221 ctctactctc gacatgttcg tcatgtttat ccctcctcac atgttcaaaa cgaatctgac 1967281 aggcaaacac ggcatcaatg ataaaatgcg ccgtcatcgg aacaaataag ttgccggtcc 1967341 attcatacat cagaccgagc aaaaagctga ttgctgtcac cataataaat aacagccatt 1967401 ttgacaaata ccgaaagtgc agagcggcaa atataaggct ggccgtccat aaaccgatat 1967461 gagtctgcag cactcctctg aataacattt cttccgcgaa agcaatcaga agcgttaaaa 1967521 atataatatg agggattgac ctcttactga atattttttt attgattccg ccgtcatcat 1967581 ataaatgaga cggaaaccat ttcattactg ccatatcggc taaaataaca ataacagcta 1967641 tagaaacacc ataccagatg attcgcatat cgcgaatgtc ccagagcttt aatacgtccc 1967701 gtacatcctc aaaaaagaac agtcctgctg cagcagcggc aaagatgatg agtagctgcg 1967761 tcaaatataa ctgcttcagc atatcatggt cagtcatatg ctgaatataa tctttttgct 1967821 gtttcagttc agctcaccta cagtctgcaa gctgaatatc cggtgcaatt ccgaactcca 1967881 gctgtctaat ggcgccattt tactccgttc ccctttttgt tcatacaagg ataaatcaaa 1967941 accgcaatgt gaacagcacg ggaggtttcc gtcatcaggc tcgtatgatt catcaaagta 1968001 ggttaacagt gcctgcctta aacagccgtc acgctgaagc aaaaatgata cacggtgcat 1968061 tttttccagc ttcagctcca tgcgatatga aatttctttc ttcatcagtt caactgatgt 1968121 ttttccctgc ataaagagat gaatcatcat acgggcctgt gtctctccga cgccatactg 1968181 aagtaatacg tcacgcagcc ttctctcatc ccgctcctcc gtcttctcta gcacacggat 1968241 tacgtcggcg atttcttcag ctgtgacact ctccatctgg ataatttgtt cctgcaattc 1968301 aaaatcccct ggcgcccgca gcaaaatgct gacactcggc tttccgtcgc gtcccgctct 1968361 gccgatttcc tgcataaaag cttctgccgt ctgcgggaga tgaaaatgaa tcacatatct 1968421 gatatcaggt ttatcgacac ccattccaaa cgcattcgta caacatatca catcaagctg 1968481 gttatgaata aactgctgct gaattaaaat cctgtcccct gactccaaac cgccatggta 1968541 aaagtcggct ctgctgctcg ttttgctttt aatttcaccc gctaattcct tagcccattt 1968601 ccgtgttgga caataaacaa ttcccggacc ttgcaggttt tcaaccagct gaatgaccct 1968661 atctattttt tcggcagtat ccgccgcatt ttcaaccctc agtgcgatgt ttgggcggtt 1968721 gactgagttg agatggcgta cagcatgctg cagctccagc aggttcatga catcttgcag 1968781 cgtttccttt gtagccgtgg cggtcaatgc cagaacgggt gggtgtccaa gtttttttct 1968841 cagctgtccg agctttgaat aatcaggcct gaagtcgtgt ccccattcag aaatacaatg 1968901 cgcttcgtca ataacaaata ggctaatcgg aacgcttttc aatttttcca atacatatgg 1968961 agactgtaaa gcttcaggag acaagtacaa aaatttatat cgatgaatat gttctaaaac 1969021 aaattgtctt tcctgcctgt taagcatgct gttcaaagct gcagcacgct tttccccccg 1969081 ggctttgagc tgctgcacct gatcctccat taaagaaagc agtggagaaa cgattaatac 1969141 catgccatca agcatataac caggcagctg gtagcaaagc gatttccctc ccccagtcgg 1969201 gagcattgca atggtatcct tcccgctgag tatgctttca ataatgtcct gctgcccttt 1969261 tttaaaggaa gtaaaaccaa aaaactgata taacgtttgc tgtaatttag tcatattgct 1969321 gcacctgctt tgtcaatgcc agtctgattt gaaagtagct gaaccgctgt tccagcccgt 1969381 cgcgaatttg tttgatttta ttcgtccgca tccgtttggc aaactctgcg atttgaagct 1969441 ggtcttctgc tgatacatag tcattaatca taaacgcagg ctcatggaga gaaatctcga 1969501 caatgtggtc ttcaatcgtc gctgttttca gctttctgat ttcagcaatt cgctgtatcg 1969561 gaaacccttg tttgaccatc tgccatgttt tcctcgtcga ctctgtcagg gcattatcta 1969621 agtgcacatc agaaaggaga tcctttaaca aagcatcttc acactccgga agagaatgaa 1969681 taaaataatg taccgaagcc caaaacatga tatagacata ccattcgtct tctttcagcg 1969741 tatcagcaag ctgcctgctc gtataaccga tccgatggtg cgaggttaag gagtagacaa 1969801 aaatttgcgc tgctttgttt tcaatctttt tcaaatgcgc ctcaagcatg gcaaaaaggc 1969861 tttttgccat ctctatatga tccgtatgcc gggacaggta tttctttacc cagtgaagtg 1969921 tcttatgatc ctttgtgaca gggatatact gcctgctccc ttgctgttta tgggatagga 1969981 cctgcacaag cagcgaaagc cttttccaaa gcacgccggc agcctgctga taatgagcgc 1970041 cgtgacaatg aacgggccaa ggccgctcgc taagggcatg tctcaaaact gctgcgccgc 1970101 tggctgtcac tttgtatgta tctgattcag acattggcgc gagatatgaa tgcttttcaa 1970161 gcttgtcaag cgacgcagaa atatcgcttc tcgaacattt tgccgccatt ccaaagtatt 1970221 ttgcagtctg aaataagccg gcatcttgaa tggtctgtga cgatctcttg cctttgaata 1970281 ggtgaaaaac agcgcttccc gaccgttccc cgtttatttt gcaaagacaa tcgagaacca 1970341 taatatcgaa gtaatttaat gacaacctat ccacctacat tcttcctgac aaaaatcgtt 1970401 gatttgctct ttttatttta acagatttca aacagaaatc gacgtttaaa gtcatcatta 1970461 agggggatgt tatgtagata accccttatg tgataagcat tctcaatcat ttttctgttg 1970521 aaatgtggca gcaacatcat tacaataagt aagaggaata ggtgttaaat tgattaaata 1970581 taaagattga tccatttgtt ccaccaagaa caatctggga ggttttattc atggcaaagt 1970641 acacaatcgt agacaaagat acatgtattg catgcggcgc ttgcggagct gctgcaccag 1970701 acatttacga ttacgatgat gaaggcatcg cgttcgtaac gcttgatgaa aacaaaggtg 1970761 ttgtcgaagt tcctgaggta ctggaagaag atatgattga cgcatttgaa ggatgcccta 1970821 ctgattccat caaagtggcg gatgagccat ttgaaggcga cccgcttaaa tttgaataga 1970881 agtaactaaa aaaagctccc gaacgggagc ttttttattt aatggatatg tgcacttcgc 1970941 tgctgctcaa tccatggctt aagcttgata aaaattagtg agaatacaac cgtaattaca 1971001 atacctttta tcatgttaaa cggcaggata cctgcgacga ctgctgtttt tagcgcgctg 1971061 tcggataatg ccggtgaatg taaaaaccac gtgtatgccg gaagaatcag aacataattt 1971121 aaaatactca ttaaaatggt catcgctgca gttcccaaaa gcaggctgac agccaagccc 1971181 tttgctgagt tgagtttttt aaataagaaa gcagtcggta atataaagag tgttcctgca 1971241 ataaaattcg caacttgccc tacaggaact ccggccatgc ttccctgaat gatatactga 1971301 agaacatttt ttatcgcttc tacggcaata cccgccaaag gtccgtaaat cagaatggca 1971361 ataattgcgg gaacgtcgct aaaatcgatt tttaaataat ccggaagacc cggaaacggg 1971421 aaatttaaca gcatcaaaac aaatgcaatg ctgctcagca tgctgaccac aactaatttt 1971481 tttactttca cttcattctc tccttttcga tcacatctta ctcgaaaacg gaaaggttct 1971541 tttccagcca ataaaaaaac cgcttcatat ataaaagcgg ggtttcgaaa attaggctag 1971601 gcaaagaaac gtttgaaaaa ttcaatttca aaacgcttat gaacctccat cttctcccat 1971661 ccagactgta ctgtcggctc cggaatctca ccgaatcctg ctgtaaagac agctcgcggg 1971721 cttagagcca ttggctcatc accgccggta gggaatttca ccctgccccg aagattgatc 1971781 atatgaaatt taattacatt ataaacgata actggttggc tgtatagaga attgcttcaa 1971841 attaaatata ttacctgcaa gctgtcagat cattgattta ttaggcttta cttttatcct 1971901 ttactgcgtc aatacacgtt gacactcttt tgagaatatg ttaaattatc agatatttag 1971961 tttgtcaatt taggaggaaa tctaacgatg tttcgagtat tggtctcaga caaaatgagc 1972021 aacgacggtt tacagccact tattgaatca gactttattg aaatcgttca aaaaaacgta 1972081 gcagatgcag aagatgaatt acatactttt gatgctcttt tggtgcgaag cgcgacaaaa 1972141 gtaacagaag accttttcaa caaaatgact tctttaaaaa ttgtcggaag agccggtgtc 1972201 ggtgtcgata atatcgatat tgatgaggct acgaaacacg gggtaatcgt gatcaatgct 1972261 ccgaacggca acaccatttc gacagctgag catacatttg caatgatctc ttctttaatg 1972321 agacacattc cgcaggctaa tatctcagtg aaatccagag agtggaaccg cacagcttat 1972381 gtcggttcag agctttatgg aaaaacgctt ggtattgtag gattaggccg aatcggaagt 1972441 gaaattgcac agcgtgcgag agcgttcggt atgactgtgc acgtttttga tcctttctta 1972501 acggaagaaa gagcgaaaaa aatcggcgta aacagccgta catttgaaga agtgcttgaa 1972561 agtgcggata tcattaccgt tcacacgcct ttaacaaaag aaacaaaagg cttattgaat 1972621 aaagaaacga ttgcaaaaac gaaaaaaggc gttcgcttaa ttaactgtgc gcgaggcgga 1972681 attatcgatg aagcagcact tctcgaagct ttggaaaacg ggcatgttgc gggagcagcg 1972741 cttgacgttt tcgaagtcga accgccagtt gacaacaaac ttgttgatca tccattagtc 1972801 attgccactc ctcacttggg agcatcaacg aaagaagcac agctcaatgt cgccgcccaa 1972861 gtgtcagaag aagttctgca gttcgcaaaa ggcctgcctg tcatgtcagc tatcaacctg 1972921 cctgccatga caaaagatga atttgctaaa attaagcctt accatcaaat tgcaggaaaa 1972981 attggcagcc ttgtatcaca gtgcatgaaa gaaccagtac aggatgttgc cattcaatat 1973041 gaaggcacaa ttgctaaact tgaaacatcg ttcattacaa aagcccttct gtcaggcttt 1973101 ttaaaaccgc gcgtagactc tactgttaat gaggtcaatg ccgggggtgt cgcaaaagaa 1973161 cgcggcatta gcttcagtga aaaaatttcc tcttctgaat ctggatacga taactgcatc 1973221 agcgtaaaag tgacaggaga ccgcagcacc tttactgtaa cggctacgta tattcctcat 1973281 ttcggagaac gaattgtcga gatcaatgga tttaatattg atttttatcc gactggtcac 1973341 ttggtgtata tccagcatca agatacaaca ggtgtcatcg gccgagtagg acgtattctc 1973401 ggagataatg atattaacat tgcaactatg caggttggcc gtaaggaaaa aggcggagaa 1973461 gccatcatga tgctttcctt tgacagacat ctggaagata aaattgtgaa agaactaaca 1973521 aatgtccctg atattgtgtc tgtgaagctc attgatctgc cataattaaa aaaactcaag 1973581 ctatatagct tgagtttttt tattgttcta tccccgtgtg tttttatgca aaatatctaa 1973641 gacactcctt agctcagaaa caggaatttg gcctggtgcg gacgcctctt ctccagctcc 1973701 aaaagtacaa gccgatccaa aaacctcacc gctcagcctg ctgatgagcc ctgttgcagc 1973761 cattgacatt gtaataatgg ggcggtctgc atatattgtt ttcattgtat acgtcgcatc 1973821 aagcagtgtt aggagatctc cagtatcatt cggcatgaca gccatttttg gaatatgcgc 1973881 gcctaagtcc tgcatttttc gaagtctgga aataatttca tcttttacag gtgttttttc 1973941 aaagtcgtga tttgacatca ccacatagac gttgttttct tccgccagcg atactaacgc 1974001 ttttacattt gcatctcctg aaaataattc gatgtctatc agatcgatgt cttttgtttg 1974061 gattgccgat tccagcaaag caagatagga gctttcgtcc atctccatgc tcccgccctc 1974121 tttgtgggtt ctgaatgtaa atagaaatag cttgtcttct aaagatttac gaagcttaga 1974181 aatgagcttt gtgaccgctt ctctgtcatt cgctttttca aatacgtcga ctctccattc 1974241 aacaatgtcc ggattcagta attttactgc ctctgcttca ttcagaattt gtttttccgt 1974301 ctttcccatc agcggaatga tgattttcgg catcccttcc ccgatggaaa ctcctttaat 1974361 cgttaacacg ttcactcgtc tcaaatcctt tcaatcttta ccttgtttta ttatacacgt 1974421 acaacttttt tttgaaaatt tctattatat gaatagcaac taaaaaagag ccttaaaggg 1974481 ctctttttag tttaaggaaa tcggatttgg agcagctggc accggaattg catctgatat 1974541 gtcatatttg ccgatttttt tcgttctggt ttccgtaaag gtcacttctg tgaagccaaa 1974601 ctcttttgca gtcaaaagta gtccctcaat cattaaaata ccggcaatag aatcatcaac 1974661 ttctgactcc tttgaaaagc ggatatataa gtgtttctgt ttcttcgtta cagattggac 1974721 agcacccgct tgaataagag gtgtcgtatc ttcttggctg ctcgattcca tttccttaat 1974781 cgcttctttt actgtatcaa aagaatgatt tgacggaacg agaaagtctt gtccttgttt 1974841 attttggtac aagtagtagg atcgttttga ctgtttggga atcgaaattt ccgtaaaagt 1974901 gccatatgag ccaatccgaa ccccagtctc attttgatcc gataaaaatt tgactttttc 1974961 ataaggactc cattttaagg attctttaag caattttttt aacagtgtat catcttttat 1975021 agaaaatgcc gtagctggct gatggactcg tatacttaat tccttctgct ttggtttttc 1975081 ctttatttct acttcatcta tgaaggttgg aattgtaatg gcatgatcaa ggatgcccaa 1975141 ttcactactt tcaaacagca tatcctggat cgtttggtct gcatttgttt tttgaatgct 1975201 gacgggtatg attgcagatg tatcggcatc agcaaccgct acagtgatgt aattgtcttg 1975261 ttccttttca ggaacgacaa acgatgtctg atccaaggac gatgcagctt ttgggctgtc 1975321 ttctgtctca gttttcgtta ctgcgttctc ttgggacgct tctttttgtt gaggctgtgc 1975381 ctgatcaaag aaatgaggag aaataatgaa ggcgatataa accgcaattg cagcggcaca 1975441 cgcggggcca atccacctga cagcgggctt atttttacgc tttgccatcg tcagccgctt 1975501 gtaaatatcc tgaggcgaac gatggtcttt aactgccgga agttgactta acaactcctt 1975561 tatctgttct tcgttccatt ctgacttcat catccattag ctcctccctc aaaagctcca 1975621 tatgtttccg aagtactttg agccctctgt gttgggtcgt ttttactttg ctttccgaga 1975681 agcgcagagc cttggctgtt tcctgtattg aatatccctg aataaaccgc aagataatca 1975741 cagctctttg atcgattgta cattgatcaa gcgcagcata aatttcccgg acattttcat 1975801 gttgaaccgc aagttcgtcc ggcagcaatt gctgatccct gacatcctgt gtatcccagt 1975861 caaatgtacc gagtatacgc tgtctgattg tttgctgttt acggaaccag tctatcgcaa 1975921 catggcgtgc gatagacaaa agccatgttt tttcactgct tcttccttca aacgtatgat 1975981 aagaatttaa tacccggata taaacctctt gaagaaggtc ttctgtctgg tttttatcct 1976041 ttaccatata aaataaaaat tggtacaaat cttgatgata tgtatcatat aataattgaa 1976101 aggtttcttc catttgaaac ccctccgttc acttttttgt cgtatgaata gcttgaaaag 1976161 ttacattaca actatattac gagtaactgg aatttggaag ggaatttata ttaacatatc 1976221 cttaaatttt attaatgttg gctattaaaa aaacacccgc tcagtcagcg ggtgtttctt 1976281 atggaacaag attcttcggc aaattcagac tcgattttac cgttttgtcg gaatataaaa 1976341 agaaaatgtt gttcctttat ctattcggct gtgcacagta attgatccgt tgtgggcttc 1976401 cacgatattt ttaacgatag ccagccctaa cccggttcct gctctgcccc ttgtccgcgc 1976461 tttatctgcc ttataaaacc gctcaaagat aaatggcaga tcttcttccg gtatgccaga 1976521 cccggagtct ttgatatcaa ttttcaatcc atccttcaca gaatggactg aaatggagac 1976581 actgccgccg gctgaagtat gccgcagcgc gttatcaatc aaattggtaa atacctgctc 1976641 catcttgtct tcatcaaaca taaattcctc ttctgtgaga gaaatgtcat gatctaaagc 1976701 aatatttttt tctttcgcaa caccggaaaa cttccgaatg atcttttcta aaaactcatt 1976761 cacattgatt ttttcataat gtaagcctgt atggcctgat tccattcggg ctaaatcaag 1976821 caaatcatta actaaacggc ccattcggag cgattcgtca taaatgattt gggcaatttc 1976881 tttccggtct tcttcagagc ttgcaatgtc atcgacaatt gcttcactgt atccctgaag 1976941 catggagatc ggtgttctca gctcatgact gacatttgcg ataaagtcct cccgcagctt 1977001 atcaaggcgg cgttcttctg tcatgtcacg cagtacggca accgctcctc tgacgtgcga 1977061 ttccgcataa agcggcgaca tcaaaagcac ccatgatctg ccttgaagcg tcatctcaat 1977121 catttgttct ttttcagtgc tgacagcgtt ttgaaacagc tcttttgctt caggcggaag 1977181 attgtcgcct tctttgatat tcatgttctg ttcataatac caagcctgaa gaaaacgttc 1977241 agccggcggg ttggtcacaa gaatcgtacc gtcaatatta atggtaataa ccccgtcagc 1977301 catactgctc aaaatgttag aaagctgctc tttttcttga ttgagcgcat tgatatgaaa 1977361 gttaagctgc cggcccattt gattaaaagc ggtcgccagt tcaccgattt catcctgagt 1977421 taaaatcggg atttttgtat cgaacttgcc cttcgccaaa tcctgcgcgc cttctctcat 1977481 ttttcggaga gggtacgtga ccctgcttga taaaaagaat gcgaaaaatg tggtcagcac 1977541 aatcgcaatt ccagcggcaa gaaaaatata gcgggtcgta tgttttgttg tatctttaac 1977601 ggcaagcaaa gactgggata aaaagaccat gcctttcttt ccgtcttttt catacgggac 1977661 acctacaatc aggcgttcat tatccgtgtc tgtatcgctc agtcccgtcc gtttgcttac 1977721 ttttttatgg tctttgagag ctttatttaa gtctttgtca tgctgtattt gctcaaccgt 1977781 aatagacgac aggcgatttt tatcattcgg agaataccag tggttcttct catcctggat 1977841 gatggcaatg cttgttaagt tatcagcgag ttcccaagtg attgaccttg ccagtgcctg 1977901 gtcctcgtga ttttctagga tgacagcaac tttattcgca agctgtgtta aatcattctc 1977961 agcttcttcc acatggtagt tttcaataaa ctccagcaaa agaaccgtta aaatgaacaa 1978021 tacgatcaag acgagtgaaa ggatcgtaaa ccacagcttg cctactacgc ttttccaaaa 1978081 tttcattcag cgccgacctc aaatttataa cctacacccc atacggtgac aatttttttc 1978141 gcagcttccg gagatacctt gttcagcttc tctctcaagc gtttgacgtg agtgtccact 1978201 gtccgtaaat caccaaaaaa ctcatattgc cacacttctt tcagaagctt ttcccgatca 1978261 tacaccttgt caggcgtttt cgctaagaaa tatagaagct catactcttt tggcgtcagg 1978321 ctcacttctg ttccatcagc tgttacgcgg tgagcatcat ggtctattga cagatgtgaa 1978381 aacacgagca catttttcgt cggtgtattg gcattgaaat aagaggtttg ggatgctctt 1978441 ctcaaaaggg cctttacacg cagcacgact tctctcgggc tgaacggctt aacaatataa 1978501 tcatctgttc ccgcttcaaa cccctgcacc cggtttgctt cttctccttt tgcggtcagc 1978561 ataataatgg gtgtcgcttt tttttcacga atttgccggc acacttcaat tccatcagtc 1978621 cccggcatca tcagatcaag caaaattaag tcataattgg cttcaagccc tttggcaatg 1978681 gcttcatcac cattttcagc ttcatctata gcataatttt cacgttcaag atacattctt 1978741 aaaaggcggc gaattctggc ttcgtcatca actactaata tttttgtttc gttcgtttgg 1978801 tccatgtttt ccccctgctt tccttctgtt actttcattt tatcaaatcg tgagaaagtt 1978861 tgagaactgt gtcgctttca aaggactatg cataagaatg aagtccggca agcacaagat 1978921 ttacgaatat taaattaaac ataataatag caaaaccgat tacggccagc catgctgact 1978981 tctcaccgtg ccagcctctt gacagtctta aatgcaagta agcggcatag aacaaaaatg 1979041 tgatcagcgc ccatacttcc ttagggtccc agccccaaaa tctggtccac gcgagctgag 1979101 cccaaatcat tgcaaagatc agcgcgccga gtgtaaagat cggaaatccg attgatacgg 1979161 ccctgtaccc aacctcatcc accagatcaa gattgacgtt tttcaccagc ggatgtaata 1979221 gagcgctgat tctttttctg atgatcagac ggagagcccc atacaacaca agacctgctc 1979281 caaatgacca aatgacagtg ttcacttttc tgcctgagaa aagcgcggga agatcaacaa 1979341 gcggttccat tcttccttcg gtcaaaagct ctccctgatg cggaccgaca agcgcgggca 1979401 tttcgtacac catcacgctt ttttctttac ttttgtccac ccagttaaac tccgcttcat 1979461 agcctgcaag acgaaatgcc gatgtgattg caataaaggc gacggttgtg accaggataa 1979521 acataatcgc ttcaagccag aaggtctttt tgcttggctt tgtctggtct acatgcttca 1979581 aaagaaagat gacaccagcg acaaagctga tggcaagtat agcttgccca agcgcggccg 1979641 ttgttacgtg aatatacagc cagttacttt ggagcgaagg aattaaaggc gagatatctg 1979701 tcggaaacat gctggcgtag gcaatcagca ataaagcaat tgacagcgta aacaggccta 1979761 atgaaggcaa tctatagaga aaataaagaa tgataaacgc caaaacaagc atcatgccaa 1979821 aagcggtggt gaattcaaac atattgctga caggcgcatg gccgcttgca gcccaccttg 1979881 tgatgaaata tcctaggtgg cagaaaaaac cgacaataga aagggtgatt ccaatgttgg 1979941 cccatcggtt tggcctgccc tttttatctt tattcccgcg tatggccccg ccgaagattg 1980001 ggacagcgat taaatacaca agaaaggccg cataaagaaa atttccgctc agctctgcca 1980061 tgacatcact cccttttcgc ctatttctgt gttttgatta attctttttg gtccaccggt 1980121 tcagtcagtc cggaatcagc caatataaat gctaaatcct tcttcaggcc aaaccagttt 1980181 ttattggtat gccctgctac cataactgca ccgtcctgtg agtgcagcca aattcttcga 1980241 tgctgccagt acataccttg aatgacaccg atcataaaaa tggctccgcc gacagcaagc 1980301 acccagagtg tcagatcctt tctgactgta agtccagtaa tgtttttcgt ttcgacatgg 1980361 tcaaatttca gcttgtattt attattgcct gatccttcga tggtttcttg gatggcgaca 1980421 aagctctttt cgcctttcgg tttgtccggc gttatgatat taaagacaaa agccggattg 1980481 ttagggatct ttgtttttgt gctcggctct ccgtcctgat taaaatagaa gtcaggcagg 1980541 tagctggcga tttccacctt gtaaccgtta ccaagatcat agactgaatc tggatccaga 1980601 aggttgatct tcaggctccc aaaggatttt tttgtttttt tatcaatcag ctggaacacc 1980661 atttggtcaa gctgattctc tttgtaatcc acctggtaaa cggaaaaaga atcaaaacgc 1980721 agcggctgat tgacacggat gtcttcttct gttacttttt ccagcttcgg cttctcgcca 1980781 taaacaattt ttccttctct cttgtagagt acggcatcag tttgaaagtt ctttgccact 1980841 ctaccgtccc cgactctgtc aatggcatct gcaaatacct ttttttccgt tttgctgtta 1980901 taggtctcta cgctgaattg attgtttttc aaataatatt ttccgtctgt acccggaatt 1980961 gctgcggttt cgccttctct gacccaaagc gtctcatcga cgtacatgcc aggcacaaat 1981021 ctcagcatcg caccaatcag aaagatgatc aatccaatgt ggttgacata cgggccccag 1981081 cgggaaaagc gtcctttttc agcaagaatg ctgccctctt tttctctgat tctataatgt 1981141 tttttcttta atagagtaac tatcttttct ttcgattccc cgttcagtac agtaactgtt 1981201 tcactgaaca agcgctgcct tcttaaaaag gccgggctcc ttctgacacc ttggtttttt 1981261 aacgctctat acaacggaat gacccgatca aggctgcaaa tcacgagtga aatgccgatc 1981321 gaggcaatga gcagcaaata ccaccaagaa ccatataaat gatgaaaccc gagcaaataa 1981381 taaagctggc caaacgtgcc gtactgctcc ttgtaataag tatcagcctg tgcgcccgga 1981441 ggcagatagg cttcctgggg aaaaatggtg ccgaacgctg atgcggcaag ggttatgacg 1981501 ataagccata ttcccacctt aaccgaggaa aagaaattcc aaattttgtc gatgatcgtt 1981561 ttgttatagg tttgcgaacg tcttgcgctt ccgtcatatc tcatatcagc gagcggaggt 1981621 tgagtttcct gaagagctct tccgcacgat tcgcataaaa cggttccgac cgggtttata 1981681 tgtccgcatt cacatttgac ttgcttcatc ccgaagtctc tccgggtttt atgagattca 1981741 tataatcgtg tatcatgctt tctgtcatag tgccggtcac caccttgaca acttttcctt 1981801 ccggattgat caaaaaggtt gtcggaagcg gagatacgtc ataggcatca agcacttggc 1981861 gatctgtatc cagaacaacc gggaaattga ctccgtagga tttcataaaa ttatgtactg 1981921 ctatctttga ctccccaaca tttacagcga caatttcaac accttggctt ttaaaatgct 1981981 tatattggtt tgccatataa ggaaactctt ttttgcacgg ttcacaccat gtaccccaga 1982041 aattcaaaaa aacacctttc ccttttaagt cactgagctc gatacgtttc ccattcgtat 1982101 cctctaggac aaaattcggt gcgtcggacc cttcggatat actctctttg ccggcaaata 1982161 cagcgttgta aatggtatag ccgagtgcgc agattaaaac gagaaggatg ccggtccgaa 1982221 tgaataaacg cctttttttc ttcattgtcc actgccccct tccccctatt gcagatccat 1982281 tcaattatat cattgcacgt tcatttcaca tttcttactt tttgaaggtt atgtgaaatt 1982341 tagaaagcgt ttttaccgtg atccgccagt gctctgagcc tttttacttc gtgaggcgta 1982401 agctctctgg catcgcccgt gtgcaggcct cgcaggttta aaaacgcgta ttcctcacgc 1982461 ttcagcttga ttacctcatg tccgatcgct tcaaacatgc ggcgcacttg tctgttgcgt 1982521 ccctcatgga tcgtcagctg aataatgctt gtctgctttt tcttatccaa agacagcagc 1982581 ttcgctttag caggcgctgt tttgccttcc tccagcctaa ttccgcgctc cagctttctg 1982641 agcagctctt taggcgggat tcctttcacc ttcgccacgt atgttttgtc tatttcatac 1982701 ttaggatgca ttagcttatt ggcgaattcg ccgtcattgg ttaaaagcaa aagaccgctc 1982761 gtatcatagt ccagacgccc aatcggataa atgcgctgcg gaatattttt aaaaaagtcc 1982821 gtcaccactt tgcgtccttt atcatcttgc gctgcggaaa taacgcctct tggtttatat 1982881 aagagaaagt aaaccggctc ttcgcgttca acctttaacc cgtttacctc aatctgatca 1982941 gaaccggtga ccttaacacc tagctctgtt actactttgc cattcacctt tacttttcct 1983001 tctttaatca gctcttctgc ctttctgcgc gacgcaactc cggcatgagc aatcactttt 1983061 tgcagtcttt ccatgtcttt cacctcaagt attatcttac ttttttcaac cttaacaaac 1983121 aagctttttc aaattcctat gccaaatcta aaaaaaacgc cgttttcagg cgctcccaaa 1983181 taataacgta acgatgatga tagatgcaac tacgccgatt aaatctgcaa gaagtcccac 1983241 ctttaatgca tcacccattt ttttaatgcc gactgctccg aaatacacag tcagtacgta 1983301 aagcgttgta tctgtagatc cctgcatgac ggaagccagc ctgccgataa aggaatcggg 1983361 cccgtatact gcaattaaat cggtcgtcat tccaagtgcg gccgtaccgg agatcgggcg 1983421 gatcagagca agcggcacta cttcagcagg gatgccgata gcggagaaag ccggttttaa 1983481 aagatccatt ataaaatcaa gcgcgcctga tgatctgaaa acagttatag cgacaagcat 1983541 tccgactaaa taggggataa tggaaaaggc aatttctatc ccctctttcc cgccttcgac 1983601 aaacgattca tatgtcggaa cctttttgat cgttccataa agaagaattc cggcaataat 1983661 gattggaatc atggctaaag acagccagtt gatgatttcc atccgctcac cttcccttct 1983721 ttttgcggcg gtaataaaaa taccgatcaa tgataatggc accgattccg gaaataagcg 1983781 ttgccaaaat gcttggcccg acgatatctg tcggcgtttt ggaggaataa gccattcgga 1983841 cagcgatcac cgttgtcggg atgagtgtga tgcaggacgt attaacagct aaaaaagtaa 1983901 tcatcgaccg gcttgcttcc gatcggtttc cgttcagctt tttcatttgt tccattgctt 1983961 taatgccaag cggagttgct gcatttccga ggccgaagaa attcgccata agattagata 1984021 aaatatagcc catcgccggg tgatccggcg gtatatcagg gaacagttta gatataaaag 1984081 gtctgcacat ccggctgaaa atatccaaaa gccctgactg ctcggcgatt ttcattaagc 1984141 caagccagaa aacaagcacg ctcatcaatc caaatgagat cgtaatcgct tctttcgcac 1984201 ccttaaacac ggcttcattt acatcttgca gagttccgtt gcacatcgca aaaacgagtc 1984261 cgatcacggt taaactgacc caaattatat tgaccatttt gctccgcctg ccgcattcag 1984321 aaagattgat ttaaacgttt caaaaaattg tttcttcggt ttttgatgcc gctcattttc 1984381 ataatagatc ggcacttttg cgatggttgc atcgttgaac atgatctcca tgtgccctac 1984441 gatgtcaggg attttcgagg catctttttc ccatgctttt ttcggcttga gcagtgtggt 1984501 attaattttt acattttctt tttcctcttc ggtcagcaaa taggtgatat cacgtttgat 1984561 aaaagccttc gattcataaa atgtgccttt cagctttgga atatcccctt tttttgcaat 1984621 taaataggtt tgataatgct caaacacata gttaaacatc ttcatatggt catcccaatc 1984681 attagggtca ttaatggtga cggctatcag gtcaatgccg tcctttgaag ccgtagagac 1984741 cagtgtccgt tttgcaagtt ttgtatagcc tgtttttcct cctgtgctgt acggataaag 1984801 catggtcagc agtttgtttt tgtttttcca tacgctttcc atcgtttccg ctttgtatat 1984861 ttttgtgcct gaaatctttt gatagtcttt cagcttcata gcatacttag ttaaaatggc 1984921 catgtcatag gctgttgaat aatgattttc atggtcgtcc aatccgtgcg ggttttgaaa 1984981 acgggtgttt ttcataccaa gctgctcggc tttttgattc atcatataaa caaacccatc 1985041 gaggctccca ccgacatgct cagcaatcgc gacagcggca tcgtttcctg atcttagcat 1985101 caggccatac acaagatctt tcagcttcac tttttgacct tctgttaaat aaatggcgga 1985161 gccttctgtt ctgacagcat ttgccgaaac cgtcactgtt tgatccattt tgccggattc 1985221 gatggcgagg acggcggtca taatttttgt gatgctcgcg atccgccttt tttgatgctc 1985281 atccttggca tataacactc tgcctgacgc accgtcaata atgatcgcgc tttttgcact 1985341 gacatctata gcagcatgtg ctgtattcac atttacggtt gcaataagaa aagaaatcat 1985401 gatcacgaat actgcttttt tgaaaatgcg catgtttgct cacgtccttg tggtggtttg 1985461 tacaagttta tgcgcatgtc catcagttat gaataacaat tatatttctg gaagcaaaca 1985521 taaaaaaact ctccctgaaa aagggagagt aaacgttatc tgattggcgc catgcttgat 1985581 ccggacgctt cgtaatgagc cagctcttcc ctcatcttca gaaaggccgc gctcaacggc 1985641 aataataatt gctcaagcga cgcaggaaca gcatgataaa actcaattgc gctgaccccg 1985701 gtataagacg cccggctatt ttcacaccac gtgtcttttt tcggcataaa gaactcttca 1985761 atgcattggt gatacacatt ataaagtgtt ttttccgctc tggcttcctg aaaaggctcc 1985821 tgcatcagga gacgacggca cgcttctgcg cctccttcac aaaatactgc cattcttctc 1985881 agagtgctaa gcacatcaca gcagtatcct ttttcaatag gcaattcagc ctgtaaggac 1985941 tcaagcgtcg tttgatttag gtaatcgttc acggtattga caaccattga taagaattcg 1986001 cctgtttttt gagtctgcgc tcgcacaatc gaatgtccca tttcgtttgg tatcttcccc 1986061 tcatgtattt gtctctcaca ttttgcttct ttcatgatag cttcttcctt atatcttatg 1986121 atgatgaaaa agcgcgattc attaaacttc tattttatat cttcgaaggt ttggttaaag 1986181 ttttcaaaaa ataaatctgc ttcttcttga agaacgtctt cttccgcatt ttcaggcagc 1986241 ggcggaagct cgtccagcgt tttcagaccg aattgttcaa gaaaagtcgg cgtagtaccg 1986301 tataaaatgg cccgccccgg accatcggca cgccctactt cacacaatag cgccttcgcg 1986361 acaagactgt gtaaaatccg ctctgatttt actcctctga tttcttcaat ttctgctctc 1986421 gtaattggct gtttgtatga aacaatggcc agtacttcta aagatgcttg agaaaggccc 1986481 tttgacggca cttcaatcag ttttttcaag taaggcgcaa agtctttttt ggtagagagc 1986541 atgtacgtat ctgcatactc aataagttca atccctcgtg tatctccgcg gtattcgtcc 1986601 gccacatccg ccatgatcgt gttcagttca ggctcttcga tttcaagcac tgttaacagc 1986661 tgcttttttg taagcccttc atcgcctgcc gcataaagaa gggcttccac aatagctttc 1986721 caattcacga tatcaagccc catgaatgga ttcactcccc gtaatgtaaa tatctgaaaa 1986781 attgtgctcc tgttcaatga ggaccagctg atttttcatc agctcaagaa cagctagaaa 1986841 ggtcactact aaatgttctt tttgctcata tggaaacaga tccataaagt taattctcgt 1986901 tcctctagat ttcaagctgt gcacgatttc gttcattctg gcttcgattg gtatgtcctg 1986961 tcttgtaatt gttgtttcca tcggcctgtt tatttttttg cgtttcagca ctttttgaaa 1987021 agctccgatc atatcataga ccgtgacaga gagcttttgc tcagactgtt ttacttcttt 1987081 tgcatattca ctcaaatcac tcggcggttt cgtgaacgat ttttgtcttt cttcttcccg 1987141 ttcttttaaa tccttcgccg catctttata ttttcggtac tcaatcagct tttcaatcag 1987201 ttcctcccgc ggatcttctt cttcaagtaa ttcatcttca aaaagctcct cctcttgctt 1987261 cgggagcagc attctgcttt taatgctgag cagcgtggca gccataacca aatactcgct 1987321 ggcaatgtcg agctcaagca cgcgcatcgt atgtacatat aataaatatt gttcagtgat 1987381 cttcgccaca ggtatatcat atatgtcaat ttcaagacga ttgattaaat gaagcagcag 1987441 gtccaatggg ccctcaaacg tatcaatttt cacttgatat tcttccatca tctcaccatt 1987501 ttcaagtatc actctcattg ccggaaaaac tggctaccct atagtataag ccaccaaaaa 1987561 gctctcgtcc aatactattt catatcctgt tttgaaggag tttgtacaga atattcaaaa 1987621 cacaagaggt gtttgctcgg agcgcagaag cgggagaaaa agcctttgct tctggttttc 1987681 ctttctaaga agcactagag gccgggcgtt cttttttcct tttatccctt ctatggtaca 1987741 ctaaaagcac attaaaggag gaagcacctt gtatccgaaa gcttatatag attatctcgt 1987801 tgagtttcat gcgacacggg attattttga atgccatgaa atattagaag aatattggaa 1987861 ggaagatccg ccaaagaaac gaaaacgcta ttgggtgggc tttattcagc ttgcagtggc 1987921 tttatatcat cacagaaggc agaatacagc cggggcaaaa agactgatgg cgaacagcat 1987981 ccggattctt caagcagaac accgggcagt cgaagactta gggcttgatc atggccgttt 1988041 gctcgaactt atgcaatcgg tttacgaaca aatcgaaacc gtctctgcct ataaaagcat 1988101 tatactgcca atcaaagatg agaaactgga ggaagcatgc aggatcgaat gcaggaaaaa 1988161 aaagtataca tgggggcagc ccagtgcact cagcaacata tttcttatcg acaaacaccg 1988221 tttgcgggat cggactgacg tcatccgtga acgtgaaaaa gaaatagaac gcagaaaaaa 1988281 aagcagagac tgatcacagc ctctgcttaa ttattgtatg aaatgtcttg atcctgctga 1988341 ccttgacaac gttcgaaaaa gctctgcgtt aattcatttg gaaccagtac ttgcgttttg 1988401 aataaatgct ttaaagcatc catcatctgt tttccgattc cttgatggcg atgagaagga 1988461 ttcacactga tatgccggat ctcaacctca gaatcctttt tttcgactcc gattgctccg 1988521 acgatatcct cgtcctcttt ccaaagaaag agctggcggt ctgtatccgt ttcgtagtcc 1988581 ttaattgtct gctgaagctg cttaaggtct ttttcattcg gcataaacga aagaagcccc 1988641 atcgcaatct tttcaaacga ttttttataa cgaattaaca taaaaacccc tctatatcca 1988701 aaatgtccag tctgctatta acggatacga ataggtgatc cgttttctca cattatatca 1988761 ttttcgccat atttttaaac tgttttcagc aaattattca aatgagcggt ttaaatttgc 1988821 catttcaatg gcagaaacag cacaatctac acctttgttg cccgcttttg tgccggcacg 1988881 ctcgatagcc tgttcgatgt tttcagttgt tacaattcca aagatgacag gtacaccagt 1988941 agtgtttgct gcttgcgcga tgccttttgc agcttcattg cagacataat cgtaatgtgt 1989001 cgttgcgcct ctgatgacag tgcccaatgt gataatagca tcatattttt ttgtttccgc 1989061 catttttttc gcagcaaacg gtatttcaaa tgcgcctgga acccaagcca catcaatgtc 1989121 atttgtgtct acgccatgtc tgagcagcgc atcttctgct ccgctcagca gcttgctcgt 1989181 aataaaatca ttaaatcttc ctactacgat tccgatttta agacctgtac caactaaatt 1989241 tccttgtatg atattcatat gattcccatc cttttttgtg atatttgtga ttagaaatga 1989301 agtaaatgac ctagcttgtt cattttggtt tgcaaatatt ttttattgtg ttctttcgcc 1989361 tccatttgaa gcggcactct ttctgaaata ctgagtccgt agccttcaag gcctgcgatt 1989421 tttcgcggat tattcgtcaa aagcttcata ttccggacac cgaggtcgcg taaaatttgt 1989481 gctccgatgc catagttgcg aagatccggc aagaatccaa gcgcctcatt ggcttctacg 1989541 gtgtcatagc cttgttcctg aagcttataa gcttttaatt tattgattaa accgatgcct 1989601 cgtccttctt ggcgcaagta caggagcact ccacggcctt ctgcggcaat ttggttcagc 1989661 gcggcgtgca gctgcggtcc gcaatcacag cgatgagagc caaacacgtc acctgtgaga 1989721 cattctgaat gcacccggac caataccggt tcttctccga acggcacatc tcccatcaca 1989781 aatgcgacat gctcttttcc atctacctca tttgtgtatc cataaacctt aaatgtccca 1989841 aaatcagtag gcagcgtaat gtcaacttca cgctcgacaa gtgttgtcag attgtaacgg 1989901 tattgaatca aatccttaat ggtgatcatt tttaattgat gctttttcgc aatttcaatg 1989961 agctcaggca ctctcgccat cgttccgtct tcattcataa tttcacaaat gacgccggct 1990021 cctggagatc cgcaagcttc agcaagatca acagcagctt ctgtatggcc cgctcttttc 1990081 aggacacctc cttttttcgc aatcagtgga aaaatgtgcc ccggacgctg aaaatcagat 1990141 ggcacggatt tgctgtccag caatgcttga acggtaaaag atctttcttg agcgctgata 1990201 cctgtcttcg tttcacgatg gtctatgctt acggtaaatg cagtgtggtg agagtctgta 1990261 ttatgctcaa ccatagggtg aagatcaagc ctgtctgcga tttcctcact gagcggcgtg 1990321 cagatcagtc ctctcccatg tgtcgccata aagttaatga cttccggcgt tgcatgctcg 1990381 gcaagagcca caaagtctcc ttcattttct ctgtcttcat catctacaac gatgatgact 1990441 tcgccttttt ttaaagcgtc cagtgcttct tctatcggat gaaacatgca aatcttcctc 1990501 tctaaaagcc gttttcgctt aagaaggctt ttgtaatggt ttgttgggtc ttattttcat 1990561 tggctttatg caaaaatcga tacatatatt ttccgatcat atcgcattcg atattcactt 1990621 tagagccgat cgttttttct gaaaagatcg tttcgctgat cgtatgcggt attaaggaga 1990681 tcgtcactgt gtcttctgtc aggccgaata tggttaagct cacgccatcc acagtaattg 1990741 atccctttaa aaccaatgtt tttgttaatg acgggtccat ttttaaatca tagtaaactg 1990801 cgttgctttt ctcttcaatt cgtgtgattt ccgcagttcc gtcgacatgg cctgagacga 1990861 aatggcctcc gaaacggccg tttgccgcca tcgctctttc cagatttact ttgcttcctt 1990921 ttgttaaatc attcagtgac gtagctttga ctgtttcagg cataacatcc actgtgaatt 1990981 gattttttgt aaaatcagtg acagtcagac aaatgccgtt cactgcaatg ctgtcgccaa 1991041 gatgaacatc ctctaaaatc tttgagcatt taatagttaa ggccattgca tgccctgctt 1991101 ttttcatgga ttcgattgtg cctgtttctt cgataattcc tgtaaacatg gtcaccatcc 1991161 tattcctttg tcggttttgc cgtcagtttg atatcacggc cgatttgggt tatatcagtg 1991221 aattgtaata aggggacatc tttcattgat tgaaaacctt caccggagat taagctggga 1991281 gcatgcgttc ctccgattag tttaggggca aaatagaaga tgatttcttg aaaacagcct 1991341 tctttgacaa agcttccgtg aacagctgaa ccgccttcca catacaccga catgatgcct 1991401 tcttccgcta ggatcttcaa aacatcagga atttgaatgc gctcggtttc aagtgtaaat 1991461 atgttcactc cgaaagctga aagccgtttt ttcttttcct cgtctgcgcg tgccgtcgta 1991521 aaaatccatg tcggcgctat ttgatcgcaa atcactttag cgtcctcagg aatcgagagt 1991581 acggtatcaa gtatgacccg aaccggctgt tttgttacat tcggcagtct gcaggttaag 1991641 ctcggattgt cggctttcac tgtgccaact ccgactaaaa tgctttggtg tgttttcctg 1991701 tattgctgag catcctgtct tgcagcctct gacgtgatcc atttgctgtc acccgtgctg 1991761 gtagctatct tgccgtcaag gctggcagcc gcttttagcg tgacgtacgg aaggcctgtc 1991821 ctcataaagt gcagaaattt ttcattcagc ctctccgcct ggtctgccag gatgccttcc 1991881 cttacctcaa tgccagcttc tttcatcatg ctgatccctc ttccagccac aagcggatta 1991941 ggatctctca tcgccacgaa cactcttttg ataccagagt tgataatcaa ttctgcacat 1992001 ggcggtgttt ttccgtaatg gctgcacggt tcgagtgtaa cgtaaatgtc ggcaccctct 1992061 gcatgtgctc cagccatatg gatggcatga acttctgcat gagcttcacc atattttaaa 1992121 tgggcgccca ttccgacaat ttgtccgtcc tttacgacaa cagcgccgac gagcggattg 1992181 gattcggtct gtccttcgcc ctgcttcgca agatctaagg ccagcttcat ataatactct 1992241 tccatttgtt tccctcccct cttttgttat ttaccgtcaa aaaagccccg aatttataaa 1992301 aaattcgggg ctttaggtat tttacgcaat aggaaataac actatgcatt tttaaacatt 1992361 ttgcatagcg gctcatcatc cttctcccat ccagactttc actgtcggct tcagcttaaa 1992421 ctgaatccac cgcgtgctta tgcacacggg tcacgggctc taaagcaaat gtgctttact 1992481 accgccggtc gggatttcca ccctgccccg aaggatacaa tctttattca tttgtcctta 1992541 ttggttatta tagcgatcct ttttaaagta cgcaatgaaa taaacttaca atttgagaaa 1992601 aacaaaacat cacccttcga tccgaaaggt gatgtttttt aatcattcac ttttgcaacc 1992661 ttgattaatc cgtcgatccg ctttgatttg ctgaagtaag ccttaatctt gtcaccttct 1992721 tttatatcag ataaatcctg atttaatttt tttccgttga agatgatttt cgttccgttt 1992781 tctgctactc catgatactc tgagccgtca attttcgtca ctttatattc ctggatggtg 1992841 tattcctctt cttccgagga caaggtttgt ccaattgctg tcggaacatc cttcagctca 1992901 atatcattta tgtacatata accgcctgca agtaaaagca aaagcactaa cagaatggta 1992961 atcttggttt ttattcttcc catttctaaa cctccagcca atatgaatct attcattcat 1993021 atgagttatt cctttttttc atgaataaaa aaccgtaaat tctcgtaaat tattaatata 1993081 acgatgcata acgggaatat gtttcacatt tctgcaaaaa tttcttttct atagatatac 1993141 gaatttatgt tctgttttta ggggatgacc gtaaaaaaga tataaaaaaa gcagccccaa 1993201 tgggaagctg cttgatccta atttgttttg cgcatttcgt taaacgggta gaaaacaaac 1993261 tttgacgtac ccgcaatttg ttttttcgtg aagaggccaa ggccgttacg gctgtccatg 1993321 gaattgcgac gattgtcacc catcacaaaa tacttgttat caggcacttt aaccgggccg 1993381 aaatcatcgg tcaaatggtc aaaaccgtcc tgtttcgctc tctttttatt agccgccaaa 1993441 taaggttcgt ccaccttttt cccgttgata tagagctggt catttttcat ctcaaccgta 1993501 tcgccgggaa ggccgataat acgtttgaca tagtgaacat catctccgtt taacacgacg 1993561 atgtctcctc tatcaaactc gccgatgtat ttgactgtca tattaacaaa aaccctttca 1993621 cggttgtgaa gtgtaggata catagagtca ccatcaacga catacggcgc aaaaataaag 1993681 ttgcggatga gcaaagcaag aacgacagca atcacaattg cttttgccca ttctaatatt 1993741 gactttttct tcgaaacatt ttctgatttc aactgatttc ctccaataaa caacggtctt 1993801 caatttatgt tatcacgaat cgaaaaaaaa tcccattagg accattgaag tgattttaca 1993861 aactgttaat cttcatcttc tacccacatc atgcctattt tttcttgtcg atcataacta 1993921 ggcctgaaaa tattgaaaga aatgaatcgc ataattcaga agcgatggac tcagaagaaa 1993981 gagagttctc atatgcaaaa tctttagatc gtatataaag catgaggtta cgggcagttt 1994041 gttcatttac tgcattccat tgatctccca gtccatgata cccatggcac ttgacaaaac 1994101 aattaacgtc atgaaggtta ctggaatgtt tgcggcaacc tatttcacag gtgataaccg 1994161 caccccgttt tttgctttca taatatgttt aaaatcattc aagctcgaaa acatggatca 1994221 gcctccaaaa aataaatcca atatattccc ggcagttgaa gactctttat tataaaactc 1994281 tgaatatccg cagttcttac agtaaaccac tagaaatcgg ttatgctgca cgtcaaacag 1994341 ctttgataat cccgtgccgg ttgtagctat ttctttttgt ccggcttcag tactaccgca 1994401 ttttatacag cctttgttgt tcatatcgcg atctcctttt cattacatca cgtttgtttg 1994461 atttatttta ctacaaaata tcaatcccaa tgacccgtac tactttaaag tttacttaat 1994521 tttgattaca tactaattgg gttcgtttct cagcttggta aatcttctgg agaaacggaa 1994581 aagctccatg accaaaacat tcaaactcag ccaaacaccg ccgaaggcgt aacccgcagc 1994641 aacatcactc ggatactgct cataaagtac acacggctca gcccgatgag gaataaaacg 1994701 ataataaaca aaaaaatgca acagtttgca gacgcgtctt gtgagaatga cgaacaaaaa 1994761 gataagcaca aaaaccaaaa atgacaaatg ccgttaaagt ctgttcgctc gggaatggat 1994821 ataatacatg actttccaaa ggagcgtgaa caggatgaag ggaatgaaag agccgtctga 1994881 ttccctcttc ataaagctcc ccaccaatga ctaggaaaaa taagaaagag agttcgattt 1994941 tccgatcttg ccctctgaat accgtccaaa aaaaagttag aacaataacg gctaacagaa 1995001 cacctctcga cgcaaaagct ttctgaattg cagctgggcc cagtctatac ccgatccaat 1995061 acgacatgct cactcccaca gctccccaat ccggccgcta acatgcttag cacccagttt 1995121 aacttttctt gaaacacgag aacaccggca aactctcccg gtccaagtaa agctagaagc 1995181 tctaacatca agacaataaa caagacggca tatccgtact gttcgagcaa ccccgtcaaa 1995241 acttgcatgt gattctcctt aaactttttt gttcttttat cattcccaat ccactttttg 1995301 tataatcagc acaattttat cttcagtcgt ccaacaacat tgtctatggc gggatcttct 1995361 ctcatacatt cttttttgac ataggaggag caatagcatg aaatgggagg aaacaaaaga 1995421 tacgcaggga gtttgccaaa attttgggca gttcgttctg ccaccgagtc aggtgtttgt 1995481 ttgcccacct catcccttgt caattcccca tttttcccgt ttgaggttcg aaatggtaaa 1995541 gtatttcact tagtttctta catgaagagg taaattcttt gctcaccgaa ctaggatagc 1995601 ggcgtatggc gatttctaca ttgcataacc actggttatt tagtgagccg tgagcaatgt 1995661 atatgcactt tgagtcagca caggatgatc ctattacatt cgccagaaaa gcagctgccg 1995721 cattcagagt agttaaaaga atagacagat atctgggctt ccggaagctt taaaggaggc 1995781 tcttttttcg agcattttta taaatcaata aaaacaggca tctcctaaat atttttgccg 1995841 ataagtttac gctaatcaac tctagcacta atacatataa aaaatagaat gatatgaaag 1995901 gagacttgat agtatgattg attatcctat taatataaac aacgtttccg ggaacagtgt 1995961 aattaacgta ggcggcgctt ttatgatcag gcctttaact ttgtccaaat ctgtgtttgg 1996021 ctccggaggt ttaaacacag gaattgtctt tgaaaataac tttgtaagca aagctaaaat 1996081 gattaatcat caatttactg atcaaaacgt caccaaaact ttttaatgta ttcaatacac 1996141 gggggtcact aactaaacac ctggttttgc caaccgccat cagcattcgg cggtttttta 1996201 ttgaacattt ttggccaata aaaaaagctt cctctctaag aggaagcctt ttgcctgccg 1996261 attagccttc tacacgaact tctttcatga catcgccatt agacatgttt ttcgcgaatt 1996321 ctaatccgct tgttacttta ccaaatacag tgtgaacacc gttcaaatga ggctgtggct 1996381 catgaacgat gaaaaattgg ctgccgccag tgtcttttcc ggcatgtgcc atagaaagtg 1996441 cgcccgcctc atgtgtatgc gggttgcctt ctgtttcaca tttgattgtg tatcccggac 1996501 cgcctgtacc agttccgtgc gggcatccgc cttggctgac gaagccaggg atcactcggt 1996561 ggaatgtaag cccgtcataa aagccttcgt tcgcaagctt ttcaaagttt gcaacagttc 1996621 caggtgcagc ttcaggataa agttcaaatt caattttgtt cccgtcttct aataaaaagt 1996681 aacctgtttt caattgtatg cctactttct ttattttaat tttcaaagga gattatgtat 1996741 aggttatagc ctgtctctcc ttgtcgcggc tattatacca cacctttcgg gggaaaacga 1996801 atctcccgag ctttactaaa aaataaaaat gaaacctgaa tctctttatc tccgtctaac 1996861 ctaacggaac tgtatttttc atgattcagg tcctcacaaa gcagcactat ccagctgctt 1996921 gtgaaattga aggaggtcaa actgctttga agaaaatttg gattggaatg ctggcagcgg 1996981 ccgttttgct gctgatggtt ccgaaggtca gtctcgcgga tgccgcagtt ggagatgtca 1997041 ttgtaacact gggtgctgat ttgtcagaat ctgacaaaca aaaagtgctt gatgaaatga 1997101 atgtccctga taatgccaca acggtaaccg tgaccaataa ggaagaacat gaatatttag 1997161 gaaaatatat atcgaacgcg caaatcggat cgagagcgat ttcttcatcg tcaatcacca 1997221 ttgccaaaaa aggctccgga ttgaatgttg agacccataa tatcagcggc atcacagatg 1997281 aaatgtacct gaatgcactg atgacagccg gtgttaaaga tgcgaaggtg tatgttacag 1997341 caccgtttga agtatccggg actgccgctt taactggatt gattaaggcg tatgaagttt 1997401 cttctgacga agcgatctcg gaggatgtta agcaggtcgc caaccaagag cttgtcacga 1997461 catcagagct tggagacaaa atcggtaacg aaaatgcggc agccctgatt gcaaaaatca 1997521 aagaagagtt tgctaaaaac ggggtgcctg ataataaagc tgacatcgaa aaacaagtgg 1997581 atgacgcagc ttctgattta aacgtcacac ttacagacag ccaaaagaat cagcttgtct 1997641 ccctattcaa taagatgaaa aacgctgaca ttgactgggg acaggtcagt gaccagctag 1997701 ataaagcgaa agataagatt acgaaattca tagaatcaga tgaaggcaaa aacttcatcc 1997761 agaaagtcat tgatttcttc gtatctatct ggaatgcgat tgtatctata ttcaaataag 1997821 aaaagcgccg aaaaatcggc gctttctttt attgctttac acccgtttta aatggcagat 1997881 caagttttac aatatcttcg tatgtttctc gcttcacgac taaatgagcc tcaccgtttt 1997941 cgacaaatac aacggcgggt ctcggaatac ggttataatt gttggccatg ctgtatccat 1998001 aagcgcctgt acaaaaaacg gcaagaagat cgccttcttt tacttccggc aggtcaatat 1998061 cccaaatcag catatctccg ctttcacagc actttccggc aattgatacc gttttgtcat 1998121 gcgcttctcc gatcctgttg gctgccgcag cttcatattt agcttggtaa agcgcaggac 1998181 gaatattgtc gttcatgcct ccgtctacag ccacatattg gcggacaccc ggcacttctt 1998241 tttgagagcc aaccgtataa agagttgtgc ctgcgtctcc cacgagagaa cggcccggtt 1998301 cgatccaaat ttccggaatg tcaaaaccgt aacgggaagc attttctttc acagcttcga 1998361 taattttttc aacgtattca gtggcatgaa gcggttcatc atcttccgta taacgaatgc 1998421 cgaaacctcc tccaagattc agcaccttgg atacaaatga atatgaatct ctccattcgt 1998481 ctagtttttt gaagattttt tccgctgcta acacaaaacc ggccgtatca aagatttgcg 1998541 agccgatatg gcaatggaca cccagcagct gaatgtgttc cgattgtaat acttgttcaa 1998601 tggcccgttc agtttgtccg ttatgaagat cgaaaccaaa ctttgaatct tcctggcccg 1998661 ttgtaatgta gtcatgcgta tgcgcttcta ctccgggcgt gatccgaaga agaacatcga 1998721 tggagtgacc cgtttcttta cataggtctt caagaagcgc gatttcatag aaattatcca 1998781 ccacaatgca gccgatgcgg tgctcaagcg ccatccgcag ttcttccctg ctcttattgt 1998841 ttccatgaaa gtggatgcgt tctgccggaa agcctgctgc aacagccgta tatagctctc 1998901 ctccggatac gacatctaaa gaaagtccct cttcctcagc gagctgaatc attgcgactg 1998961 atgagaatgc tttgctcgca tatgccacct gtgctttcag ccctgcagaa ataaacgcct 1999021 gcttaaagct tttagcacgc tcacgtatta aagccacatc atatacgtaa agaggtgtac 1999081 catatttctc cgctaaatag agagcatcca cacctccgat ttctaaatga ccatgttgat 1999141 tttgtctgct tgtgccgtgt aagaacaatg tcattccctc tttctccgct tatggatgaa 1999201 aggacagttt tatggactgt cccttcataa ttaagacata cattatcata ctcttcagtc 1999261 agtttcaatg cgattatgaa ttggtaggct gccttaagcg atttttgggg tgaacgatgc 1999321 tgggtcttac ttttgcgcca ggtttcgctg tgcggacaag aacctgccac agcgcctttc 1999381 cgttaaaggg aatcagcggc cataagtacg gtgtctgaag ggatttgatg cttgccatgg 1999441 caataattag cactgtaaat ccgatgacga gcccttttat atgaaataaa gcaacgagta 1999501 tcatgaggac aagacggctc attttgtttg ccaagcttaa ttcataacta ggcgtcgtaa 1999561 aggttccaat cgccgcaagt gagacgtaca gaatcacctc aggagaaaaa aggccgacct 1999621 caatcgcaat ctgcccgatc agaacagcgg caattaaacc cattgctgtc gataaagccg 1999681 tcggtgtgtg aatggcagcc attctgagaa actcgattcc taagtcagct aaaaatatct 1999741 gcaggatgat cgggatatgc gtatctttat ttaaaccgat aaatttcatg ttgtccggga 1999801 gcagatcagg ctgaagcaca aagagaaacc agatcggaag aaataaagta gaagcaagaa 1999861 taccgaaaaa tcttacccga gctcgtggtc attcggcata attacttaaa ttttgtccag 1999921 tctcccatcg tccgctttaa gaatgtgata aacccggctt tcttcatatc ttcttttgca 1999981 gcaacaggac tttcagcgag tacttctcca tcctttttca gaacaagagt gccaagctct 2000041 tggccttttt gaatcggagc actaatattg tccttcatct tgatttcttt tttcacatcg 2000101 ttcatatcct cgcctttttt cgtcaatatt gaaatcggct cagatgtagt gagttcgata 2000161 aatttttgtt tccctttttt gacctttact tttgctactg tttgatttcg tttatataaa 2000221 ggatgcgttt catattggct aaaggcgaag tcaagcattt ttgtcacttg cgcgtttctt 2000281 tctttaggcg tgctcgctcc gaatacaacc gctatggccc gcatgtttcc ttttttagcc 2000341 gaagcagtca gacaatattt cgcttcgcct gtatagcctg tttttacgcc gtctacacca 2000401 ggataaaatt tgataaggcg atttgtattt acaagccaaa actttttatc tgtattttca 2000461 cgcagataat cttcatacgt gccggtaaac ttcgtaattg attcgtattt caataattcc 2000521 ttagccatga ttgccatgtc ataagcagag ctgtagtgtc cttcctcggt cagtcctgtt 2000581 gggtttttaa aggatgtatt tttcaatccc agctcttttg cttttttatt cattttcttc 2000641 acaaattctt cttcagagcc ggaaataaat tcagccatgg cgacggaagc gtcatttccc 2000701 gaagcgattg cgatgccttt cagcatttct ttgacagtca tttcttcgcc gggctcaagg 2000761 aatatctgtg agccgcccat tgacgccgca tgctcgcttg tacggacctt atcactcatt 2000821 ttgattttgc ctttatctaa agcttccata atcaaaagca tcgtcataat tttcgtcatg 2000881 cttgcaggcg ccagtctctc attgctgttc ttgttgtaaa gcacttttcc cgtgtcacgt 2000941 tctatcagca ccgcagactt cgcttcatga gcaagctccg atgtacgttt tccgtcttgt 2001001 tttgcaaatg cagacggtgc aaatgtaagc agcattatac caatcaacaa agtggataaa 2001061 agacgtttca tctcaaaagc cctccatttc ataatccttt ttattttttc caagcgtgat 2001121 ggttttatac gccactgatg gaaaatgttt cgaattttgg gcataaaaaa agacagctgt 2001181 gtgatatcag acacagctgt cttttggtcc tgcattgatt catatttatt cgtactgagc 2001241 gacgatcgct ttaacaagct ttaagaatcc agcttttact ttttcggtca cttccataac 2001301 ttcatcgtga cttaaaggct gatccagaat tccggctgcc gcgttagaga tgcaggaaat 2001361 gccaagaacc cgcattcccg catgattcgc tacaatgact tccggaacag tagacatgcc 2001421 gactgcatca gagcccatcg ttcttaagaa acggacttct gccggtgttt cgtaagaagg 2001481 tcctgtcaca gcagtgtaca cgcctttttg aattgggata ttaaggtctt tcgcaatctt 2001541 ttcagccagg ctggacagat ctttgtcata ggctgaagac atatctggaa atctggcgcc 2001601 gaaatctgct tcgtttggcc cgattaacgg gtttgttccc ataaagttga tatgatcggt 2001661 aataatcatt aaatctcccg cacggaattc agtgttgaca ccgcctgcgg catttgtcac 2001721 gatcaacgct tccacaccga gcgctttcat cacgcgtaca gggaatgtga ctttctccat 2001781 tgagtagcct tcataaaaat gaaagcggcc ctgcattgca atgacggaaa ctccttcaag 2001841 agtgccaagc acaagctgtc cggcatgccc ttcaacagta gataccggga attcaggtat 2001901 atcttcatat ttcagcttga ccggattttc gatttcgtcc gccaaaatgc caagacctga 2001961 gcctaaaata aggccgatct ttggagattc cggcaggttt tgtttaataa aagcggctgc 2002021 gcgttcaatt ctgtccttca agaaacagtc cccctattgt aataaagata aaaagctttt 2002081 cccgtatttc ggtttatttg tttggaaatt atcagcgatc gttgcgccaa tatcggcaaa 2002141 tgtatctgca agcggcagca tttgcgcttt cttatgtttt ttgctgtaag cgagaatcgg 2002201 cacatactcg cgtgtatggt cagtcccatg atgaatcgga tcattgccgt ggtcggctgt 2002261 aataattaac agatcgtctt ctctcatttt ttcaaacact tccggaagcc gcgcatcaaa 2002321 ttcttcaagc gcgcgtccgt agccttcagg gtcacggcgg tgtccgaata acgcgtcaaa 2002381 atcaacaagg ttcgcaaagc tcagacccgt aaaatcttct cccagcgtat cgatcacctt 2002441 gtccattccg tccatattag aaaccgttct gcgtgaagaa gtaatgcctt ctccgtcgta 2002501 aatatcagag attttaccga ttgaaatcac atctaagccg cagtctttca attcattcat 2002561 gacagtgcgg tcaaacggct tcagcgcata atcatggcgg tttggcgtcc gtttgaattg 2002621 acccggctct ccgacgaacg gccgtgcaat aatgcggcca accatatatt tcggatcaag 2002681 cgtcagctct ctcgccgttt cgcaaatgcg atacagctcc tcaagcggca caacctcttc 2002741 gtgagcggca atttgcagaa cagagtcagc agacgtgtaa acaattaaag cccctgtctc 2002801 catgtgctcc tggccaagct catccaaaat cgctgtgccg gaagccggct tgtttccaat 2002861 aattttgcgg ccagatctct tttccagctc ttgaagcaat tcatcaggaa agccttccgg 2002921 gaacacttta aacggtttat caatgtataa acccataatc tcccaatggc cggtcatcgt 2002981 atctttgccg tttgacgctt cttgcatttt tccataatag gcaagcggat gttctgtttt 2003041 ttctacacct ttgatatctt cgataagacc aaggccgagc tttgccatat tcggcatatg 2003101 taatccgttc atatgctcgg caatatgacc gagcgtatga gcgccttcgt cattaaagtc 2003161 agcggcatcc ggcgcttcgc cgattccgac tgagtccatc acaattaaaa acacacgatt 2003221 atatttgtat gcaggcatct tgaaagcctc ctttttttct atacgtctat tgtatcgcta 2003281 agaggtctga caactcaagt ataaaccgtt ttcattcccg ttgacaatgt atttggaaat 2003341 aatgagaaac ttcaatattt tctgtcgctc taaacaaaaa agccgcagcc acctgcggct 2003401 atgctcgcgg atgaaactgc ttgtacacat ccttcagcct tgttttcgtc acatgcgtat 2003461 aaatttgcgt cgtggatata tccgcatgac cgagcatttc ctgcaccgct cttaaatctg 2003521 ccccgttctc aagcagatgc gtcgcaaagg aatgcctgag tgtatgcgga gtcagctctt 2003581 tcttaatgcc ggcttccaat gcgatttttt tcaggttctt ccaaaatccc tggcggctga 2003641 tctgtttgcc gtgatgattt aaaaagaggg cgtcagatac attatttttt aacagttttc 2003701 ccctggcttt tgtcatatat tcctcaatgg cggaagcagc ggcttcaccg attggcacaa 2003761 tccgttcttt tcttcctttg ccgaagcatc ggataaaccc catagataaa tgaacatcag 2003821 ccgttttcaa ttcaatcatt tcactgactc gtatgcctgt cgcataaagc agctccagca 2003881 ttgctttatc ccgatatccg aaagggctcg tcagcttagg cgtgtccaat aaccgctcga 2003941 cttcattgag cgcgagcacc ttcggaagcg cccgttccgt cttttgtgtt tcgatatgaa 2004001 cggaagggtc cttatccgtt actttttccc tgagcagaaa ttgatgaaaa gagcgaatgg 2004061 atgccaaatg ccgcgccgat gtcttgccgg atttccccga gtccttcaaa tgctttaagt 2004121 attggataat atgtatgcgg gtaacgtgat tccaatctgt aacatgaagg gtttctgtta 2004181 agtagagaga atagcttttc aagtcacgtt cataggatac gatcgtattt tgagagagcc 2004241 ctctctctac cataacgtag tggatgaaat cctttatttg atctttcact cttgatctac 2004301 tccccgtttt ggtaaaaaaa gatcaaccgg tcgaaccatc cgcctttttc atcctgatcc 2004361 atttcaacaa cttttacagc ggagccttcc ggtttatcat accgatgata gttttcatac 2004421 tcttgattca cccatatcat agcataatag aacaaagcgg taaaaccggt aaacaggatg 2004481 aaaactttca atgcatcgac agctgttttc aggaatcttc ccatgtccta atcgatcctt 2004541 tccctatggt tccagttata taaaccatat gccaaatcag aaaggtttta tacatagaaa 2004601 cagcaaaaaa ccctttcccc atgagaaaag gttcgcgctc ggcaccgtct attcagtttc 2004661 ttttccgtta cagcggtggc aaatgccgtg aaacgtcaat ctatgatctt taatcttaaa 2004721 tttccaatca cgttcaatga tttcttccac gtcttcaagc aaatcttctt caatttcatc 2004781 aacggctccg cactccatgc acaccaagtg gtgatgaaag tgagctgcgc cctctttccg 2004841 aaggtcgtaa cgggacacac cgtctccaaa gttaatttta tctacgactt ttaattcagt 2004901 taataattca agcgtacggt atactgtagc gagaccgatc tcaggagatt tctcttttac 2004961 gaggaggtat acatcttctg cgcttaaatg gtcttcttcg ttttcaagca gcactcttac 2005021 tgtcgcttca cgctgtggcg taagtttata gctggatgag tgcagttgtt tcttaatacg 2005081 atcaatacgg ttttccatgt ctttccctcc tacgccgcat tccatgactc attataacaa 2005141 aatacgcgca gagttccaac tataattatt ataaactgat aaataaaatg gttttctttt 2005201 aataatgatt ttaaaaaagt ctagatgtaa gcttttccat taaaacagga gataagtatg 2005261 cttcaaagag agatgaaatc agcgctaaaa acagaatgac cagcagcaca aaggcatacc 2005321 gcccgaacca ttgaatcggc gcgtcatgca ggcttcgttt cacgaacagc tgtctgatta 2005381 actttaaaga aaacgcaatt gcacatgtgc ccataatgag ataagccgga atcagcagca 2005441 cattttgcgg caaaacggag acaaatgata ggaaaaaccc gcttactccc atctgattga 2005501 ctaggaaccc gacagtaaag ccgacgacga tccctttcag aaagatcata atgaaaataa 2005561 tcggcatccc aatgacggaa attcccagta tccacatcag gcctaaatac tttgcattat 2005621 gaaagatact ttgcccaaac atatcagctg aacttgcctg ttttccatcc gaaagctgtc 2005681 caaaaaattg acttaagtag tagtataaat cttctttctg gctgatggtc atactgttga 2005741 caataatcgc gccaaagatg acacccatga aaaacagcac tgacacaaat atataaagag 2005801 agagatgatc tttgacatgc ctgagaaaca tgtccttata agagattttt cgcataccgt 2005861 ttcctcccgc ccgctctagt gatttgattt aatagattgt atgaaagaaa cagaaaaaca 2005921 tgcccttttt caaaaagaaa caatagagat gaatgctagg cggctttttg gggcacaaaa 2005981 aaatccttat catcaactgc tgtatgatca taaggattct tatgcttccg tttattcaaa 2006041 atctcttttt tgctttttgt cattcttcca tgtgtgctga aagatggtgt gctgcctctt 2006101 gataataaga cgtcacgtcc gccgtttctc aatcgatgcc cccgcttctt tttcgcttgg 2006161 ctttttgcca tgtgatcact ccctttttta ttttcatagt aatgataaca aaattgaaca 2006221 atgataagaa aaaaacagca cctgctacga caggtgctgt ttagctacat ttatttcact 2006281 gctgtaagag ctgcatgctc gacagctgct gctaccgcat gatggacttt tgaatcaagc 2006341 ggctgaggga caacatcacc ttgtttagtg caagctgcga tggcctctgc tgctgcgaca 2006401 agcatatcat gattaatctc cgtgcttttt gcgttaagcg ctcctctaaa aatccctgga 2006461 aaaccgagta cattattaac agaacgcccg tcagctgcat atgcggcgcc agcctgcagt 2006521 gcggcctccg gctcaatttc cggcttcgga ttcgataaag ccagaatcac ttgaccagaa 2006581 cgtacaaatg ccggttttat taaacccgga acgcccgttg tagcaatgac aatatcacat 2006641 gtttccataa gctcctcaat actggaaact gcctgtccgc cgtattgttc gagacggttc 2006701 attgctgact ctgatttgtc tgttccgtat acagcattca caccataagc catgaacatc 2006761 cggcagatgg ccacgcctgc tgcgccaagg ccgatttgcc ccactttcgc ttccttcagg 2006821 tcaacccccg cactcctgca tgccgaaatg gcagctgcca gcgtcactac agctgtacca 2006881 tgctggtcat cgtgcataac agggatgttc agctcctctt ttaggcgatc ctcgatttca 2006941 aaacaatgcg gcgaaccgat atcctcaaga aggatgccgc taaagcccgg agaaatatgt 2007001 tttactgttt tgatgatttc ttcaggatca ctcgtatcaa gcagtatcgg aatgccgcta 2007061 atacccgcca gctgatcaaa taaagcagcc tttccttcca tgacaggcat gccagccaca 2007121 gagccgatat tcccaaggcc taaaattgcg gttccatccg ttacaattgc aacagaattg 2007181 ctgatcgttg tataaataga agctttttca ggttcttttt cgatcagtcg gcacacgtcc 2007241 gcaacacctg gtgtgtagac acgtcccagc tctgccagtg aacggatcgg cattttgctt 2007301 ttcatttgga tttttccgcc ttcatgtgcg gacaggactt catcagatac ggtgtgaagc 2007361 ctgatccctt ctccgagggc ctgtacagcc gcgatcactt cctgaagctg ttcttcattc 2007421 tccacttgaa cggtaatatt ccgcattgtg taattgggtc cgacttttac cgtctccact 2007481 tcaccaatat ccccgcccag aaggccgatg gccgtagcca cccttccaag atttccggga 2007541 accgaaggcg tttcgatcat cagtgtccga atcatgtgtt tcgctatcat tcagtgatcc 2007601 tcccctatta gcctagtttt tcggctttaa ctgtattgtt tttcgtatac catataaatt 2007661 ttcctgtata accatagata attgcaagac ctattgctac aaaactgagc cacataaacg 2007721 gcagataaga gaaggtagaa acacctaaaa taccagccat gtaaatccca ttatcagacc 2007781 aaggaaccat ccccgaagtc aatgttcccc cgacctctga gttacgtgat aacactcttc 2007841 tgtccagatg taagcgatca tagctgtctt ccataatttt cggagtcaaa ataagagata 2007901 catacatcgc acagccgaag atgtttgcta aaaacgctac gatcagtgta gacaatgtga 2007961 cattgccggc tgaagttaat ttcttttcaa acgttgaaac aatgactttt aacacgccga 2008021 gtttctcaag cagaccgcca aaaccaaggc caaagatgat gacgacgaga gaatcaagca 2008081 taccgacaat tccaccgcgg tttaacaagc cgttcaaaaa ttcaacatcc gttttaatag 2008141 agaagccgtt gtacgcagtt gcaatcgcat gggcaatatc cattccttgg aaaacaacag 2008201 cccagattgc accgagtaaa gcgccaatta cgataactgg catagatggc tttttcatcg 2008261 ccaataagac tatgacgaga actgccggga tcagcatcca aatatgaatg tcaaacgtgt 2008321 tttgcaaaga tgattttaag aattcaactt tatcaagatc aatatttttc ccgccgtaca 2008381 taaatccaac aactgtaaag agtatagctg taatgacata agcaggtatt gataaataaa 2008441 gcattgctct cacgtgagcc aatacatcga cttttgatag tgaagaagct agaactgtac 2008501 tgtcagacag cggagacagc ttgtccccaa aataagcacc tgaaagaata gctcccgcta 2008561 ctagaggaag cggaatgcct aacccctctc caattgcgat catggcaatg ccggcagttc 2008621 cgactgttcc ccatgacgtt cctgttgcca cagacataat ggaacaaata attaacgttg 2008681 ccagtaaaaa gatacttggg tgaataaatt ccagtccgta ataaatcaaa gtcggcacaa 2008741 cgcctccggc aatccatgtt ccgatgagcg ccccaactga aacgagaatc agtacggctt 2008801 caaggccatt tgatatccca tgtacaatcg cattttgtaa atctttataa gaataaccga 2008861 gtctaatacc taaaagcatt gcaataaacc atgaaacaaa aagcgccagc tgtatcggca 2008921 agtcgagaaa gactgtaaac gatagaacaa gtgctaaaaa tactcctagt acaataataa 2008981 tttcaaatag tgttggcaat cttacatcct tcaaaagaag tcccccttca tgtaaaagct 2009041 aaaacgcttt caatatatag tgcaacacgt atactatact tcctcatccc tatgttgtaa 2009101 acagcttatt catccgacta ttcggagatg aataagctgt attttataca aattttattt 2009161 ttctaatagt tctttccctg cgatacctgg tttggtcatc tcatatgggt ttaaaataat 2009221 atccaattct tcttcagtca gcacatcatg ctgcagacaa agatcccgga cagattgccc 2009281 tgtcataatt gcttccctgg caattctagc tgccgcttca tacccaagat gcggattgac 2009341 agctgtgatc acgcctgcgc ttttttctac gtattgcttc atacgctttt cgttggcttc 2009401 aatgcctttt aagcagttgt cagtgaacga acggaagccg ttgttcatga tgctgatgga 2009461 ttgaagcaaa ttaaagacaa gcacgggctc catgacgttc aactcaagct ggccggcttc 2009521 tgaagcaagg cagattgtat tgtcatttcc gataacctgg aacgcaattt ggttgatcag 2009581 ctccgccata accggattga ctttccccgg cataatagat gaacccggct gacgtgcagg 2009641 cagagaaatt tccgcaagtc cggcgcgcgg tcccgacgcc attaagcgca ggtcgtttgc 2009701 gatcttcgac atgttcatca tgcagacttt taatgaagct gatacctctg tataggcatc 2009761 tgtattttgt gtcgcatcaa caagatgatc agcgccgaca agaggaagcc cgctaatatc 2009821 agcaaggtgc tttactacct gtttgatata ttcaggatca gcgttcagcc ctgtaccaac 2009881 agcagttgcg cccatgttga cttcatacag gtgctggcgc gattgcttga ttcgtttgat 2009941 atcacgctcg agaacacggc tgtaagcttc gaattcctgg ccaagacgga tcggaaccgc 2010001 atcttgaagg tgtgtccggc ccattttaat aacagagtca aactcctgtg ctttttgctt 2010061 aaacacacta tgcatatctt ccattgtttt cagcagtttt tctaagagct tcaatgtgga 2010121 aatatggata gcagtcggga acacatcgtt cgtagactgt gacatgttca catgtgtgtt 2010181 tggacttaaa tggatataat ctcccttttt atgtcccatg atttcaagcg cccggtttcc 2010241 gataacctca ttcgcgttca tgttcataga agttccggca ccgccctgaa tcggatcgac 2010301 gataaactga tcgtgccact tgccttccag aatctcgtca gcggcttgta cgatagcttg 2010361 gccaattcct tcatacagcc gtttcacgtc catgttggca agagccgcag cttttttcac 2010421 aatcgccagt gcgttaatca tttcctcatg gattttgtat cctgtgatcg gaaaattttc 2010481 agaagcacgg agcgtctgaa ttccgtaata aacatctgct tcaatttgtt tttccccaag 2010541 gaagtctttt tccacgcgat attctttttg gccgtttaac ataatcttta accttctttc 2010601 tctttgctgg ttatcgtttt tacattttac aggacaacgt catcagctat cggcgtttcc 2010661 ataattctct tgacgacagg aagatccgaa gactgaccta gcgcccacat caattttggc 2010721 acaattgctt ctgtgttcat atttcttgat cggataatta agtcttggtt gactctgcgg 2010781 ccaacctcgt aaatgctcat gtcttcgcct tcttcaagac attgagtcgt aatgacgacg 2010841 acaatgccgc tttcgatcag ttcattcact tttgacaaaa tgtctctgcc ttcaaacggc 2010901 actcctccgc tgccataact ctcaatgaca attcctttgt acatgctttt cagggcatca 2010961 aacatttcgg gctttaagcc tggatgcagc ttcagcagac atacatctgt gcatagtgaa 2011021 gtgtcaactg tgaaggtgtc gttctcaggt tccgttactt gtttgttgta ttcgatcccg 2011081 tcttcattga taaaagcgat atatgggtaa ttgatgcttt caaatgcgtc gtagcttttc 2011141 gttcttaatt tgatcgcacg cgttccctga atgactctgc cgtcaaacac aacataaacg 2011201 ccgcccacgc cttcacaggc aaatcgaatg gcatctgtaa tatttttttt ggcatcggtt 2011261 ttttggaacg tgatcggaat ctgcgagccg gtgatgacaa tcggcttttt ggcatgctgc 2011321 agcatatacg atagtgcggc agatgtatag gccattgtat ctgtaccgtg agtaataaca 2011381 aacccgtcat aggcatcata attttcctta acggcttctg ctatttccac ccagtattca 2011441 ggctgcatat tggtgctgtc tatattcata agcgactgag tttccattgt gtaatcgtta 2011501 tcaagttttg atacgtaact taataattca tcagccttga ctccgggagc cagcccattt 2011561 tccccttcaa ctgaagcaat cgttccccca gttgtcaaca tcaataattt tttcatacca 2011621 tgcacctctt cactgtatct aaagatgggt tgcgagaagg tattcgcttt tcgcatactt 2011681 ttaatgcaat tatagacacg gaaaataaaa tacgcaagac attattattc aattcgcgta 2011741 cacttcctaa tacctatatg atataatcag ctcaaggtga aaaaggagcg gaagttcatg 2011801 aatctagatc gtttaactga attgagaaaa aagaaaaatt ggtcgcttca atatacagct 2011861 gaccttctcg gtatcgcaaa aagcacatat gccggctacg agtcaggcta ccgacggcct 2011921 tcacttgaag cgcttgccat gctggctgac ctctttgaca caacctgcga tgaactttta 2011981 ggccgcgaga aacaaaagca gactgctcct caggccatag aattggccac gtggagcagc 2012041 ctcgacttta ccatttctgt tgatggccag ccgctgagtg aagatgaaat catccagctg 2012101 attaccttta tacgcacaaa aagaaaagta caggaggaac tgagttaatc tttagctcac 2012161 ggtttaattt taccgtaggt tcctcctcct ccggctttca attccagttt tccggatctc 2012221 gcttttacga taagcgccgc ggttttcggc gggacaacgc gagccaaatc ttcttctgca 2012281 gcctcatgaa gaacagccat ttctgttccg aaggcttttt ttagtttgtc cagcgttttc 2012341 gggcctacac ccggaacaaa ttgcagcggg atctgatgta catatcgcgg acgcgggacg 2012401 cgaacttcaa gctgatcact caattcacgc aatctatcgc tgactccctt ggtaaatctg 2012461 gcttttccgc aattcgcgca cgctgtttcc ccgcttacag caggctctcc gcacgcttcg 2012521 caagccgtct gataatattt ccccaataac gggtccaagc cataatttgc gataattttc 2012581 ctgtcatctt gtccctttaa tgcaagagca aattcagtaa aatcagctga ctgcacatat 2012641 aattcattat attctctgcc gattttcccc aacgaatgcg catcagaatt tgttaaaaaa 2012701 ggatacggat tcaattgcga tacgtgtgat gccatgtctg tatcacagct taatccaagc 2012761 tccaccgcgt ctatcataga tggatcaaaa acctcagtta agcttgattt aacccctttt 2012821 ccatataagc ttttatgcgg cgtaaagata tgggcgggga taaacaggcc gcccatatcc 2012881 tgcacttttt tttgcaggtt taagcccgtt tcataaatcc gctgcgagct taaatgaata 2012941 tttttcagcc gggctgacag ccagtttgaa aactgtttca tatcagccag cgtcggcata 2013001 aatacgagca catggatcgg tccgctgcag gcttcatcat aaatctccag ctcgctcccc 2013061 aataaaagag tcgtgctgcg ataacggatt cctcccccgt caagctcgcg atattttcca 2013121 gatgaaatgc cttcctcaag ctctagaatg acttccggag aatgacagtc gataatgccg 2013181 aggagttcaa ttcctttatg ttcactggct tcaaccaaaa ttctgtccag cgttaatgtt 2013241 ttggcgcctg ttattttgac agcccttcct gtaaaggtcc ggccgatatg aatgtgcaaa 2013301 tccgcgtaaa tctttttcat ttttgtgctt ggagcgcttc tttcagctga agatactgaa 2013361 tcgcgtaggc tgttttagca tcatatactt cacgcgattc aaccagcttt agcgcatctt 2013421 caagcgtcac ctccatcact tcaacaaact cgtcctcatc aagctcccgt ttttcttcaa 2013481 gcacagaaag ctcctcagca agaaaaacgt gaacgatttc atctgcaaat ccgggtgatg 2013541 tataaaacgc agttattttt gtcagttttt ttgctgtata accggtttcc tcttcaagtt 2013601 cccgaagtgc cgtatactcc ggctcctcac ctttttcaag cttaccggcc ggaatttcaa 2013661 cgatcgtccg ctcaagcggc ttacggaatt gtttgaccat gatgattttc ccttcatctg 2013721 tgacggctag taccgctaca gctccagggt gtttcacaat ttcacgttta ctggctttgc 2013781 cgtttggcag ctctacatcc tcgacataaa gatcaatgac tttacccgaa aaaatctgtt 2013841 ctttggcaat tgttttttct tctaatgatt tcatttcttc atctcccgtt ctgtctctat 2013901 atgatgcccc atacatttta tcatactaga gcaaaagggg gcttcttcgt gaaagtgcac 2013961 cgcatgccaa aaggtgttgt cttagtcgga aaagcatggg aaattcgagc gaagttaaaa 2014021 gagtatggac gcacatttca atatgtgaaa gattggatct caaagccata aaagttgaaa 2014081 ctttagctcc tttatattac ggtcaataca aagcctaaaa aaggagtgtg cacatgagaa 2014141 agcgcaaatt gggtacatct gatttagaca ttagcgaagt cggactcggc tgtatgtctc 2014201 ttggaactga aaaaaacaaa gcattgtcca ttctggatga agcgatcgag cttggcatca 2014261 actatttgga cacagcggat ttgtatgacc ggggacgcaa tgaagaaatt gtcggtgatg 2014321 cgatccaaaa cagacgccat gatattattc tggcaacaaa agcgggaaac cgttgggatg 2014381 acggaagcga gggctggtat tgggaccctt caaaagctta cataaaagag gcggtaaaaa 2014441 agagccttac acgtctgaaa acagattata tcgaccttta tcagctccac ggcggcacga 2014501 tagaggacaa cattgatgaa acgattgaag cgtttgagga attaaaacaa gaaggtgtca 2014561 tccgctacta cggcatttct tccatccgcc cgaatgtgat taaagaatat gtaaaaaaat 2014621 caaacatcgt cagcattatg atgcaattca gcctgtttga cagacgccct gaggaatggc 2014681 tcccgctttt agaggaacat caaatcagcg tagtcgccag aggtcctgtt gccaaagggc 2014741 tcttaactga aaaaccgctt gatcaagctt cagaaagtat gaaacaaaac gggtacttgt 2014801 cctattcatt cgaggaactg acaaatgccc gtaaggcaat ggaggaagtg gctcccgatc 2014861 tttccatgac agaaaagtcg ctgcagtatc tgctagcaca gccggctgtc gcttcagtga 2014921 ttacaggcgc cagtaagatt gagcagttac gggaaaatat tcaggcagca aatgcacggc 2014981 gtttaaccga agaggaaatc aaagcgctcc aatctcatac gaaacaagac atttacaaag 2015041 ctcatcgctc atagcagaaa aaccagcacc tgtacgggtg ctggtttatt tatattgatg 2015101 ccaatccatt tggctttcat ttaggagttc ttcaaagctc ttattttttt cgatctcttt 2015161 tttctttcta atctgttctg ctttttctct tttctgcctc ttttcatcct cttccttcaa 2015221 ttggctcttc atctccataa gctttgcttt gatatcggat tgaaggccgt cttttagctg 2015281 gtgtttgtca atggattttt gttttttcat gcagacttcc cccatgtttt gttttgaagc 2015341 cagtttatca cggagcatat aaactgaaca agcagactct cttctgatca ctttctcagc 2015401 gtagcagtgt ttaggtataa tgatcttaaa cacgaattgc ctatatattt cgttgaaagg 2015461 tgctgtgact tttgaagaaa atccttttgg ccattggcgc gctcgtaaca gctgtcatcg 2015521 caatcggaat tgttttttca catatgattc tattcatcaa gaaaaaaacg gatgaagaca 2015581 ttatcaaaag agagacagac aacggacatg atgtgtttga atcatttgaa caaatggaga 2015641 aaaccgcttt tgtgataccc tccgcttacg ggtacgacat aaaaggatac catgtcgcac 2015701 cgcatgacac accaaatacc atcatcatct gccacggggt gacgatgaat gtactgaatt 2015761 ctcttaagta tatgcattta tttctagatc tcggctggaa tgtgctcatt tatgaccatc 2015821 gccggcatgg ccaaagcggc ggaaagacga ccagctacgg gttttacgaa aaggatgatc 2015881 tcaataaggt tgtcagcttg ctcaaaaaca aaacaaatca tcgcggattg atcggaattc 2015941 atggtgagtc gatgggggcc gtgaccgccc tgctttatgc tggtgcacac tgcagcgatg 2016001 gcgctgattt ttatattgcc gattgtccgt tcgcatgttt tgatgaacag cttgcctatc 2016061 ggctgagagc ggaatacagg ctcccgtctt ggcccctgct tcctatcgcc gacttctttt 2016121 tgaagctgag gggaggctat cgcgcacgtg aagtatctcc gcttgctgtc attgataaaa 2016181 ttgaaaagcc ggtcctcttt attcacagta aggatgatga ctacattcct gtttcttcaa 2016241 ccgagcggct ttatgaaaag aaacgcggtc cgaaagcgct gtacattgcc gagaacggtg 2016301 aacacgccat gtcatatacc aaaaatcggc atacgtaccg aaaaacagtg caggagtttt 2016361 tagacaacat gaatgattca acagaataaa aaagcgaaag gcctcttcgg ctctttcgct 2016421 tttttatgtt acagaacgtc ggtaatgcca tccatatttt ctctgatcca ttcaatcgca 2016481 agatctatcg ttgtaaactc ctgcgtctcg aaggtcattt catcctgcaa tagccagaca 2016541 tctttcttga tggactctgc tcctccgatt gaccagtgaa gcaaggtata aggatggttt 2016601 tgattcagga aggataccca cgttttattt tgtgctgtgt tcttcattgc cttcagcttt 2016661 tgttccacgt ttcgcgtctc ctactttact aatatgctca ttctggggct gagcatttca 2016721 gccgggcttt tcagcgccaa tgttttggct ttttcattgt aatcgatcgt catttgatcg 2016781 tcaaaaaaca ctttttgcga cgattggata tacagcggaa tgccgttcgt ttccagctgc 2016841 tcgcactgtc ccgttaattc ttctgccagc cagattgtcg ggacaccgct taccgcgcag 2016901 ccgcatcctt ctgcatcgta acgaagctgg gctttttttc ccgggttggc gtcaaacgcc 2016961 tgctgcagtg cctgttttgc tgcatctgtc acatgtatgt tcataaggtg aaacccccgt 2017021 tttcatcatt ttcgctattg tagcatacaa tactgccatt cgcattgttt ctgccttttt 2017081 tccaccgctt cgcattttct tctgcagtct tgatccactc atctttccct tgtatatact 2017141 gattgatgct gtcagggtgc tgggccgcca gctgtttttt gagaacggcg tattctttcg 2017201 ctatgtttgg atgagctctg agataatctc tgaataacag atgcctttca atagcagggt 2017261 ttccctgttc gtacatatgg acatgatgag tgcgtttatt tccgcccttt tggaaataac 2017321 gcctgcccgc tataccgttc tcaccttttg gtgtatagcc gttggccttc atttgttcat 2017381 caaattggct cacggcttca atgcttctga cttcaattaa catatcaatg attggcttcg 2017441 ctgccatgtt aggtattgat gtgcttccga tgtgatgaat agcgataatc tccggcccga 2017501 acacaagttt cagccgttct ttttcttcat cgaaacattc tgcccatttt tcgttgtaga 2017561 gaatgatctc aacttttctt ttcggataca aatgaaagac cgacagcaat agaccctgcg 2017621 ctgctttgac ggtttctgcc ttttggaatc cggcctgtgt atagagtgac acagccgggg 2017681 tattgttctc ggctgtgact acttcgattt tctcagcgtc ttcattatga tcaatgacaa 2017741 attgcagaag cgctcgtcca attccttttc tgaaaccgtc aggatgcaca acaagcctgc 2017801 aaatggtgag ataatgcatg tttttctcat atgaaatgac accgatcagc ttgccgtttt 2017861 tccgatatcc cgcaaaccgt tcatgggatg cttgaatatc ctttaccttc tcttgtaaag 2017921 cgggaatacc gtcaaaaccg ataatctctg tttcctttat gtaggcgggg atctgtacgg 2017981 ctaaaatctc acgcgctata gtggcttcct tatgctggag aaattcaatc attcgtgttc 2018041 tcctgaaaca gccgctgtct gtcgactttt gcgacgcgga ctgcatacga ctcgtaccaa 2018101 acgcttcttc ctttttcttt tgctgcttga tgttcagtgt gatgcctcca atggttaatt 2018161 gcgtccatac tgtcccaata ggaaactgtg atgccccttc catccgcttc acgtacgctt 2018221 tccacgccta aaaatccagg ctgatccgcc gcaagtgata ccatccgctc cgctgtttct 2018281 ccatatcctg tgtcattttc gcttttgaca gaagaaaaaa tgactgcata gtaaggaggc 2018341 tcaggtgttt ttgataaaaa atccatcata tttccccctc atatgttttt gacaaatagt 2018401 accctgtctt ggcccgggcc atcatagttt gcaaacactg agatgccatt taccgttttg 2018461 gtgccctttt caatatcaaa ccccaatttt gtgtgatatg cgattgatac cttattcaca 2018521 ggtgaagtga cacacttcac ccgggtgcag cccctttgtt ttactgtttc gataaataca 2018581 tcatacaatt gtttcccaat ttgcattttt ctgaaatccg gatgcacacc ggaaaaatga 2018641 atgtacgccg tttcaggatc ggattgcgat tgaaatccga ttaaaaatcc cgtcatgctg 2018701 ttatgttcgg atgtaataaa gcttgtgtcc tgaaaatgct caaaaaatag tctcggcaat 2018761 ttttctttca gctgtctgcc gccccaccat tcattcagta cagacgttac catttcataa 2018821 tctgaagacg tgattgttcg aatatccatt acgatttgat ctccctccgt ctggcaaaac 2018881 gaatgtcagc tctttttctc acaatataaa aattatattt tgcctggctg gaattgtaaa 2018941 tgccttcttt cctgtatcat acgtttccag actgccgagg gaacaatgtt tgatcatttt 2019001 acgcctattt ctcccccaaa caggaggaga gactttacag cacaatatca agcacttgat 2019061 caagtttcag cttataaagc tgatcctcgt ctccttttat ccatactgct ttttcaaact 2019121 cttcataccg gcagattttc ccggtgcagc agacaatctc accgtcctga aagcagctga 2019181 cagtgatatc ctgagcaaac tccatcgcgg cgcaaagcgt ttgattcatc tcttccagct 2019241 tatcggggtc aaggatcggc ttttgcagct tctgtttaag tcgctttctc tccagcaggc 2019301 tttgcttatg ttccggcaga aacatcctgc tcccttccca cagcaggttg ccccttttta 2019361 aatggtcgtt catttataat gcccccctat tttagccgca cgttcaaatg cctggcctgc 2019421 cgctgtcagt gacgccgccc tgatgattgc tgtatcgccg aatcgatttt taatgccatc 2019481 catcacatag cctaggctca ttttctttgc ataatcctga aataaattga gctgccatat 2019541 gtcatcagat gagagctgag acagattgac accgaggcgg cggacgggtt tcccgtccca 2019601 aaatgtaaga aacagccgtc gtacagcctc atatacatcc tgcgtagaat tagtcggctc 2019661 tgccagcttc acttgccggt tgaagcccgt cggccaatca aaatcagcac cccggcagct 2019721 cactgacact gtctgcccca tgaccccggc gtttcggctt cgcctgcaca cctcttcact 2019781 cagctcaagc aatacgacct tgatttcttt gtcaaagtgt tcgtagtctc tcgggagagt 2019841 cattccatga cctatcgcct tttgcccgtc cagagacgaa gttgacacag gggaatagtc 2019901 gattccgttt gccgtcatcc acagcacgtg gccgttaatg ccccatttct tttttaaaag 2019961 atcgagcgga aaagccgcga gcccgccgat cgtgctgatg cccattcgat ttaaatgatg 2020021 cttcatgcgg ctcccgacgc caaacatgct gcccaccggg agcggccaca tttcggtttt 2020081 catattttct ttcgttaagg taaaaatacc gttcttattc tttttggcaa aattgtcaca 2020141 cgcaattttg gccagcgctt tgttagggcc gattccgacc cgtgcataaa cgccgatctc 2020201 ccgcatgatt ctgccctgaa tgcttttcgc gatctccatc ggcgtcccaa acagcttctg 2020261 gctgcctgta atgtccatga actgttcatc gatggaatac ggctccacaa ggtctgtata 2020321 ctcctcgaga atggccgtaa tttgcagtga tacatcaata taccgctgca tacgcggccg 2020381 gagcacaaca gcctcaggac acttttcctg cgcctcccac agccgtgaag cattcaccac 2020441 acccttttgt ttcgccagcg ggcaggcagc caatacgact ccgccccttt tttcagggtc 2020501 acccgaaaca atgacgggcc tatttttcaa atgtggattt tccgctttct ctacagatgc 2020561 ataaaacgat tgcatgtcaa cgagaaaaat cactttttct ttcatcatac acacctctaa 2020621 aaagaactta tgttcgcttt tcattatatg cgaaagtatg ttcgttttat actggtaaat 2020681 gattcttgtc tgacagaaaa tatgatccaa gggtttgaga gaagaaaaac atttagtaga 2020741 ataaaagcga agcataagga taggagagtc atgatggaga aatttgtcga aaaaatgctg 2020801 ggacaggcat tgcggcaata cggcagaaac gttgctatag atccgttaag cccgtatgaa 2020861 aaacaaagcc tgaaagcggc tctacaagag agacggaatg aagaaccaga tgaggatttg 2020921 catgcgcata tagaagatat catttatgac tatgtcacaa accaaggcct gttctcttaa 2020981 acgcatgact gtcagttctt tcagccgctg atgcggcttc cctttgaaaa caccgcctga 2021041 aacaaataaa cagtctcagg cttacagaaa aaaagcagga ttttctcacg ctccatagat 2021101 tcatatggcc tggcgtaaaa ttcccctcaa tgctcgcgca aaacggaata agctgtccat 2021161 gatcacgcgt atacactttt tcgaagagat gtgctctctt gttctgtcat gcggtccatg 2021221 ccggttttca gcgtacatct tgatctcata gccggtttca ctgccgatat gatccacgtt 2021281 ctggcggctt aaactaacac accctcactg accaatcgct ttgcttttca tcggacatcc 2021341 cgtcattttc cttctttcaa gatgtaaact ccgtcagcca cacgcatcct caacgcatag 2021401 tatattgcca tccatacaat caggcatact acatgtcaat aacgaaatat tttgaacgat 2021461 ctattggaga aggaaatttt ttcatatatg atagagaaag atcatacata caggagagaa 2021521 tataattcat gaagaaatgg aaagatatcc acccgatcag ctggacaatt ataatcggaa 2021581 ccattttcgg cagaatggca acatcgatga gcattccttt tttagcgatt tatttgacag 2021641 ccgtccaagg cgcatcagct tcctatgcag ggctggtcat cgccgcgagc tcatcagtcg 2021701 gcatcctcgc aagcttttac ggcggatata tctcagataa attcggcaga aaaaacatga 2021761 tgcttgtatc gattttcgga tggatgctgg tatttgcagg ctttgcggca gcatctaatc 2021821 tctgggtgtt ttttgtagta aacgcattaa acggtctttg caaatcactg tttgagcccg 2021881 cttcaaaggc cttgttgtct gatatgacag aagaaaaaac gagactgcta gtttttaatt 2021941 tacgctatgc ggctattaat atcggcgttg tcttcggacc tgtgcttggc ctatatttcg 2022001 gctcatcgca atcgactacg ccctttttgg tgcctgcagt catttacgga ctatacggaa 2022061 ttgtgcttgc cctccaattt aaaaaacatc catccttatc agcaccagcc cagtcccgaa 2022121 atatgagcgt gcgggaagcg tttatggtca cgcaaaagga ttatcttttt accattgctt 2022181 tggtcggcat tacgctatgc accttcggct actcacaatt cagttccaca ttccctcagt 2022241 atatggcgca gaaccccttg atcggcaatg gaacgaagct gtatgggctg atgctgacat 2022301 taaacgcaat cgttgtgttg gcgacgcaat ttcccattgt ccattttgca aaacggtttt 2022361 cgccgctttg ttctctgatg ctcggtaatg tgatggttag catcagcatg gccattttca 2022421 ccgtatcaca cggtgttcca tcaattgtga tgattgtcat cacatttaca atcggcgaag 2022481 tgcttttatt ctctatgatg gatttgtatg tagaccagat tgcaaaacca ggattaaaag 2022541 gcacttattt cggggcaatc ggtttttcac agctcggaaa cgtcatcggc ccttgggtcg 2022601 gggggatatg tatagacctg tttggcgctg gccggccgat ttatattttt tctgtcctga 2022661 gcggcattac cctgctcggc ctgccatttt tagcgttcgc ctatcggcaa atgaaaatgg 2022721 agaccacaaa acaccgttcc cgtctggaaa agccgcttta aataaaaaac ggaagagaat 2022781 gaatctctcc cgcaaacatg aggtgaagaa catgaatata ggtgatgtga tgtttcagct 2022841 gtttgtattt attatatttg ccgctgtcgt ctttgcggct gttacaggct tcaagtatgc 2022901 gaaaaaccga aaagcgcagc tggatcgcat tgagaaaaag ctgaacagcc tgtccgaaga 2022961 tcacgattaa cagcttgggg caacgagctc taccttaatc cggtctggat cctcacaaaa 2023021 gactgcataa tgcccgtctc ctccggcaaa aggatgcctg tctcggtaca acacacgata 2023081 gccttttgcc gtcaattttt cagtcatctg atcgacttga agcttggatt cagcatgaaa 2023141 tgcgagatgg ttcagaccga ctcggcatct atggtattcc ggctctagaa atggctcttt 2023201 cgcctgcaca atcactaggt aaaaacgatc tttcttccag ctgatgcctg agctccattt 2023261 ttgatactct ttataaccaa gttcttttaa gaaccagccc caaaaccgcc tagacgcctc 2023321 caaatcagag acatacagtt caatatgatg cacatttcat accctcctta ccaacacttc 2023381 ctcgacctta tgcccgtctc ccttacgcaa aatgagatct gacctgaatt tagttggcaa 2023441 aatattttca tataaattcg gccggttgac actctcccaa atcgaggctg ccatctcgtc 2023501 agcctcctga tcggacaagt ctttaaattt atgaaaatat gaatcaggat tttgaaaagc 2023561 tgtttcccga agcaggcgaa aacgctctaa ataccaagtg aaaatccggc tttcctccgc 2023621 atccacataa atcgaaaaat caaagaaatc ggaaacaaaa atacgcgggt tttcccggtc 2023681 atcctccaag gtgggcgact gaagaacatt aatgccttca ataatcacaa tatccgcctg 2023741 ttctacaacc tcgaacacac cttcctcgcg gtcataggtt agatgggaat acaccggggc 2023801 ctttacgctg tcctttcctg attttaagtc attcaaaaat tcgagcagcg cctttacatc 2023861 atagctttca ggaaatcctt ttcttgacat catatttttc tttttcagct cggcagtagg 2023921 aaataaaaaa ccatctgtcg tgataaggct cacttttgga cggtcaggca aacgcgaaag 2023981 cagcttctgc aagatccgcg ccgtcgtgct ttttccgact gcgacactgc cggcaatgcc 2024041 gataataaac ggaattttgg ctgaatgtgg gtgcttcaaa aaaacattga catgcttatt 2024101 gcgttcagcc gcagacttga catgtaaatg aagcaagcga acaagcggaa tatagatcgt 2024161 ctccacttct tcaacagata gataatcatt caatccttcc acagcttttg cctcttcttc 2024221 agatacagca atcgacaaat gccccccaaa accagaccaa gactcccgat tgtgctgtgt 2024281 atataaagta tgtaggttaa gttctttatt tttcactgtt tacacctgac tctctgtagg 2024341 ttaaaaccct tacaaagatt gtaacggaaa accttttcac tgtctgctta tttttcattt 2024401 cgttttttta gcaaatcagc accgattcgg ttatacgcag ccatttcatc ttttggaacc 2024461 atgcttcctc ccgttcccca gacgacatgt acggcatgtt ccatcttata tttctgagca 2024521 tagcgccttc cctcttctgt cgaaaaaagc tgaaccggcc cgaacatgcc agcaagagca 2024581 gagggctcta aatatttatc ttcagataca gccagcatat gaagcaaagt ataaagcgta 2024641 ttgtcctcta ccgtataaca gccgctcaga agcggttcaa tcagcttgcc gacaaatcct 2024701 gacggcctcc ctacggcaag tccgtcagca gccgtctgat tatccaggcc gatatcctgg 2024761 acggagatct tctcgtgaag tcctgaataa agccctaaca gcatacaagg tgaatgagtt 2024821 ggttctgcga aaaacacatg aacatcatct ccgtataaaa gcttcagccc aaatgctaca 2024881 ccgcccggtc ctccgccgac tccgcacggc agatacacaa acaagggcgt ctcaagactt 2024941 ggctttatat tcatacagtc aagctgtgtt tttaatcggc ttgcagcaac agcatatcct 2025001 aagaacagct gacgagaatg ttcatcatca ataaaataac agaatggatc ttgttccgcc 2025061 tgccgtctcc cttcgttcac cgcttcactg taatctgttt cgtactccat aacagtgact 2025121 cccttttggc ggaggagatc ctttttccac tgcttagcat cggcggacat atgcactgtc 2025181 acgcgaaacc cgagtgccgc gccgatgatg ccgatgctta aacctagatt tcctgtcgaa 2025241 ccgacagcaa tcgaatagcg ggagaaaaac ccggtaaacc gctcttcctg taagatgcgg 2025301 taatcatcgg tttcctgaag cattccttct tgaagcgcga gattttcagc atactttaac 2025361 acttcataaa tcccgcccct cgctttaatc gatcctgaaa tcggaagctc atggtcgcac 2025421 tttaaaagcc atcttccggg aaatggctgc tgatatgccg cttccagctt tcccttcata 2025481 tgctgcacct caaaaagcgg agactcgatg attcctttag cgcctttcgt ctcaggaaac 2025541 acctcggcaa tgtaaggtgc aaaccgctgc attctttttt ccgcttccgc tatctcggtt 2025601 gcccactcat ctgcacgggg taatggcccc tctttcttgc ctgaatttgc ccagaataca 2025661 ggctctgcat caatcagttt ctgaataaac ggatctttaa gcagagcatg aaggacttct 2025721 gaatgaactg acattcaaca atctctccct tccactatca aaaactgccc cgtgagaaac 2025781 aagccactcc accacaggca gttctatcat tattttttca tgagcgcgcg tcctgccagc 2025841 ttttctacaa gagctggaaa cagctgatac agcttagtgc cggcattcat taaacgcgga 2025901 agattgatct cccgcttttt cgtaaaaatt gcagctgtaa tttgagctgc cacgtcatca 2025961 ggatcaagca tccagcggcc gacatttttg gcgtagtccc cgcctttatc agcaatggaa 2026021 aaaaagtccg tctgaatcgg gcccgggttg actgttgtca cataaatgcc ggttcccgaa 2026081 agctccatcc gcaaagcgtt tgagtaacct aacacggcat gtttggtcgc ggaatacagg 2026141 ctagacttcg gtgtggcgat tttccccgct tgagaggcga tattgatgat atgtcccttt 2026201 ttttgctcaa gcatttgcgg aagcaccgct tttgtacagg cgatcaggcc gaagacattc 2026261 acatcaaaca tcgctttcat gtcatccaat gtagagtcta aaaccgtttc aaatataccg 2026321 aagcctgcat tgttaatcag tacatcaatc gagccgatct gatcgcggac ccgggcgata 2026381 tcctctaggc ggccgacatc cagaggaaaa atctcacact gtccgctcca ttcctcggtt 2026441 attttccttt tgatttctat caaacgatcc tcgcgtctag ccgacagcag gacatgggct 2026501 ccttcagccg cgcataagta tgcgattctt tctccaagcc ctcctgaagc gccggttatc 2026561 caaatccttt ttcccgctat atgtttcacc catttcacct cttcattgtt ttaaagtata 2026621 cggtatttcc ttcccaatat gacgtgatgg cttcttcagc ctccaacaca tcaaggtgac 2026681 ctgccgtttc tgacatcgtt aaaaacaatt ccttttcata tacagcagga aaaagctgct 2026741 gacagacctg aaaagcggtc atcggctttt catccagcat gcgacgcaca tcctccgtcc 2026801 tgttcctctg cttgtcaaaa cgcttctcaa tcagcgcttg tacactggtg ataggctcgc 2026861 cgtgaccagg aaatacgatt gttggatcaa gttgagacag ccttcgcaat gaccgctgat 2026921 aatccactaa aggctttgac ctgacgtctc ccgctttcgg cgcttccaaa atcggattag 2026981 acgagctgtt tgccagcagt agatcgccgc caagcatcct tccgcttttt tcatggaaca 2027041 gaacaatatg cgattcagca tgtccaggca tctccaacac agaccagccc tcaagcccat 2027101 ctatgcccat accttctctg attgattttg tcagagatct cgtacaggaa aatgcgtacg 2027161 ctgatcgaat cagcttttcc gccttccccg tatcaaatgg aacgcctaat tcaggcagca 2027221 gcttttgaaa aaaacgtttt tgccaatcca taaaggcttg attttggctg atataaggtt 2027281 cgttgaatgt atgcccaatc acttcgattt catctgaaaa gacatcaagc aagcctgcat 2027341 gatcagcatg atggtgagtc agtacaacct gctcgatatc tgacaatttc acatttacag 2027401 cggcaagctg ctcttgtaag gctctggcag cctcttttgt attcggcccg gcatcgataa 2027461 gtgtcagcgc atcacctttt acgaggtaaa cgataacatc gccgacagca aacggtgtcg 2027521 ggacgcggat cgcaattaca tcttcagttg tcatcctttc gctccttgtc ttcattcatt 2027581 attcatattt tagctttttc tcggtcttgt gtcattattg cagaatgaga acaaaccttt 2027641 ttgaaaaagc tattgacatt agcttgtccg ccattgcata atgaacaaca aactaaaacg 2027701 agaaccattg gaacgctatg acgaggaata gtatacaagg caatggccta agagagcgat 2027761 acccccggct gaaaggtgtt gcggcccgct tgtttgtaga acctgccctc aagtcgcggt 2027821 taggaaaacc taaacgtttc ccgcgttacg gggatttgag ctgagcacaa tttgtgctaa 2027881 tgagggtggt accgcgaacc ttttcgtcct ttacgtgatg aaaaggtttt ttgttgttct 2027941 aatagaagga ggatatcaat gaaaaagata ggatttgtcg gcgccgggtc aatggcagaa 2028001 gcaatgatca acggcatttt gcaaagcggc atcacaaaac cagaacatat ctatattaca 2028061 aatcgctcaa atgacgagcg tctgattgaa ttaaaggaaa cgtacagcgt gcgtccatgc 2028121 agagataaaa atgagttttt cactcacacc gatatcatta tcctcgcttt caaaccgaaa 2028181 gacgcggcgg aaagcatcga cagcatccgg ccgtatatca aggaccagct tgtcatttca 2028241 gtacttgcag gccttaccat cgaaaccatt cagcattatt ttggcagaaa gctcgcggtc 2028301 attcgcgtca tgcctaatac atcagcggca atcagaaaat cagcaaccgg attttccgta 2028361 agcacggaag caagcaagaa tgatattatt gccgcaaaag ctctattgga aacaatcggt 2028421 gatgcaacac tggttgagga gcggcatctt gacgctgtca ctgcaatcgc aggcagcggc 2028481 ccggcctatg tgtatcgtta tattgaggcg atggaaaaag cagcacaaaa agtaggatta 2028541 gataaagaaa cggcaaaagc actcattttg cagacaatgg caggggcaac agatatgctc 2028601 ctccaaagcg gcaaacagcc ggaaaagctg cgtaaagaaa tcaccagtcc tgggggcact 2028661 acagaggcag gtcttcgcgc tttacaggac tcccgctttg aagaagcaat tattcactgt 2028721 attgaagaaa cagctaaacg gagcgcagaa atcaaagaac agtttgccgg tgccgcctta 2028781 gagagacatt cttagatgta aggacaaaaa cagaaggcac agtgccttct gttttttatt 2028841 tttcccgcag cagctggccg gcagattctg attgctttaa tagcgcggag atcgtaaatg 2028901 aaagcaaatc gggaagcact tcaaaggaat aaggcatata caatctttcc gtccatttat 2028961 gcgggtcttt accagccgga ccgacattta aaactgggac atataaagcc tgatttttac 2029021 cgcttggcaa tgaataccct ctgttaaaga gcggcatatt gcttgtgtat gcatcaacct 2029081 cctgtttttc cagctgaaga taactcaagt ccgaaagtcc ggggaagtac tgaacctccc 2029141 gtaatgcaat gccgtatcgc tcagccgcat aatgctttat ctgatctgct gtatttctga 2029201 tcaattgatc atcctttgaa gaaacagctg gataaagcgg cggactataa aacagaacga 2029261 tgagcggcgc atcctcctta caaagcgaag caagctcaga aacaattttc gtcgaaaaat 2029321 ccctgtctcc aagctccccc ctgttagcaa aggcataatt tagagcccgc tctgtttccg 2029381 agatccccgc acgctttttt gcacgcgaga ccagctcatc aaatgtcaaa acagtgacgt 2029441 cccgctcaat cggctgaaat ggctcaaatt gttgaaaatc ctgtgttttc ttccgaacgt 2029501 tcgacatgat ttcctccgcc gcctgttctg ctgttttaag cagcatctga tgcagctcac 2029561 tagctgagcg tttcattgac agcacattaa ataatgtgac ggctgtatgc ggtgtctgga 2029621 ctgaatatgc ctctttcaag tccttttgca ttaagtttac cggcggcgga gtgacctcgc 2029681 catcaacctt ttcgcaataa tcagcattca gttcaagcaa acggttaatc tcagatacca 2029741 ttaaatttgc gtttagacct gaaaacggct ctccaacatg tgtctcaatc cccttgcaga 2029801 aaaaacccgc aagcaccttg ccaatgcttc ctgtataaaa atattgctgc tgatcgccgg 2029861 gaaatttttc aaacatcggt tcggcattca ggcaagcggt taatgtgata tcatgctttt 2029921 tctccatctc cttcaatgca ggaaccgctt caatcatgcc tcttgaattc acttcctcgt 2029981 ccggaaccgt tatcaacagc agattgccct caaaatgccc gttcattgcc ctctccagca 2030041 tcgacagttg aatacaaagc cccgctttca tatccatcgt ccctcttccg aacagccagt 2030101 ctccgctttc ggcatctctt ctcacacgtt ccgggagcag ctcttttttc tctaaaaagg 2030161 agctcaaaag ctcagcaggc ttgcaagcca tatgtttaaa ttcgccgtaa tcttctatgt 2030221 caacgacatc aaaatgactc agcagaagca ctgtcttttt gacattcttc tttttgacta 2030281 gagccgtaag aaaagatctg ccatcgtcca tcggatgaag tgttacatca tcagggtgct 2030341 tttgaaaata gggcttgtcc ttcaaaataa aataaagata ctctgcaagc gctacctcgc 2030401 cctttgaacc ggtgatgctt tcgtattgca caagagaagt taaaagtgcc agcaattcgt 2030461 ccttcgtctg ccaattcatt gattccgccc ctcctatgaa taaaaatgct tctatactga 2030521 aaaataaact gatttctcgt ctattataca gaaatgtttg acaaaagcgg ttcatttgag 2030581 cagtttatat gacgggaaag aaatgacttg atataatcaa tctctaaaaa ccttacggga 2030641 ggcgaaagaa atggccagaa aattatttac acctattaca attaaagata tgacgttaaa 2030701 aaaccgcatt gtcatgtcgc caatgtgcat gtattcttct catgaaaagg acggaaaatt 2030761 aacaccgttc cacatggcac attacatatc gcgcgcaatc ggccaggtcg gactgattat 2030821 tgtagaggcg tcagcggtta accctcaagg acgaatcact gaccaagact taggcatttg 2030881 gagcgacgag catattgaag gctttgcaaa actgactgag caggtcaaag aacaaggttc 2030941 aaaaatcggc attcagcttg cccatgccgg acgtaaagct gagcttgaag gagatatctt 2031001 cgctccatcg gcgattgcgt ttgacgaaca atcagcaaca cctgtagaaa tgtcagcaga 2031061 aaaagtaaaa gaaacggtcc aggagttcaa gcaagcggct gcccgcgcaa aagaagccgg 2031121 ctttgatgtg attgaaattc atgcggcgca cggatattta attcatgaat ttttgtctcc 2031181 gctttccaac catcgaacag atgaatatgg cggctcacct gaaaaccgct atcgtttctt 2031241 gagagagatc attgatgaag tcaaacaagt atgggacggt cctttatttg tccgtgtatc 2031301 tgcttctgac tacactgata aaggcttaga cattgccgat cacatcggtt ttgcaaaatg 2031361 gatgaaggag cagggtgttg acttaattga ctgcagctca ggcgcccttg ttcacgcaga 2031421 cattaacgta ttccctggct atcaggtcag cttcgctgag aaaatccgtg aacaggcgga 2031481 catggctact ggtgccgtcg gcatgattac agacggttca atggctgaag aaattctgca 2031541 aaacggacgt gccgacctca tctttatcgg cagagagctt ttgcgggatc cattttttgc 2031601 aagaactgct gcgaaacagc tcaatacaga gattccggcc cctgttcaat acgaaagagg 2031661 ctggtaatgc ccataagaga tatcctgtag aggatatctc tttttttatt tttagagaaa 2031721 cgatcggcta aggttctccg tctccctagt agaaccaatt agaggagatg actccaatga 2031781 aatcagcttg gatggaaaag acatatacaa ttgacggatg tgcgtttcat acacagcacc 2031841 ggaaaggatc aagcggtgta acgattgtct ttgaggccgg ctatggtact tcttctgaga 2031901 cgtggaaacc attaatggcg gacattgatg atgaatttgg cattttcaca tatgatcggg 2031961 caggcatagg aaaaagcggg caaagcagag ctaaacgaac agctgatcaa caagtgaaag 2032021 aattggagag tttgcttaaa gcagctgatg taaaacctcc ttatttggct gtttcacact 2032081 catacggagc tgtcatcacc ggtttatggg cctgcaaaaa caagcatgat attatcggca 2032141 tggtccttct tgacccagct ttaggcgatt gcgccagctt tacctttata cccgaagaaa 2032201 tgcacaaatc acatacgaga aagatgatgc ttgagggcac acatgcagag ttttcaaaaa 2032261 gtctgcagga gctcaaaaag cggcaagtcc acttaggaaa catgcctctt cttgtgttgt 2032321 catcaggaga acggactgag aaattcgctg ctgaacagga gtggcaaaac ttgcacagca 2032381 gcatattgtc tctatctaac caaagcggct ggattcaagc taaaaacagc tcccacaaca 2032441 tccatcatga tgaacctcat atcgttcact tggctattta tgacgtatgg tgcgcagcgt 2032501 gccagcaggc cgctcctctt taccaggcag tcaattaacg taaaaaaaga ccgggccgta 2032561 agggattccc ggtcttttat attattttgt ttcacggtga agggtatatt tctttaaacg 2032621 cggtgaatat tttttcagct ccaaacggtc tggattggtg cgtttatttt ttgttgtgat 2032681 gtaatttcgg tctcccgttt cagtgcaaag ctaaagtaac atttactctc ataattaaca 2032741 tctccttata aaacgtaatg attacgtttt attatacaac gtcatcacaa attgtcaaat 2032801 aagagctccg ccttcagcct cgcgggacgt ttacctctaa gaaatcatat gccgccacgc 2032861 tattggggaa aacgtcaacc gcttcttttt gaagctccaa agaagcatct ccctgatatc 2032921 ttgcgctgat atgggttaaa atgagctgct tcgctcttgc ttctttcgct gttacagccg 2032981 cttgttccgt tgtactgtga taataatcat aagcaagttt acggtcttcc ttagcaaagg 2033041 ttgcttcatg aacaagcaca tcacaatccc tcgcaagctc ttttagtttg tcacttactc 2033101 tcgtatcacc ggagaacaca acagatcttc cctttttagg aggctccaga aaatcattcc 2033161 cattgatgat tcgtccgtct tcaagcgtta ccgtttcgcc ttttttgatt ttctgatata 2033221 caggtccggg cgggatgttc atttctttta atacgtcagc cttcaaggaa cccggtacgt 2033281 ctttttcctg cacacggtac ccgaaggctt ccactccatg aataacagat accgctgtga 2033341 caataaactg atcgtcctca aacacgattc cttcttcaat ttcctggatc gcaagcggat 2033401 atgtcaaatg ggttttcgtg acggcaaggc ttgtttcaat aaacgccttg atccctttag 2033461 gtccgtacac tgtcagctcg tcctctccgc cttgaaagga acggctcccc agaagccccg 2033521 gaagtccgta tacatgatcg ccgtgcatgt gtgtaataaa gattttctct attttacgag 2033581 gtttaatcgt tgtatgtaaa atttgatgct gtgtggcttc cccgcagtca aaaagccata 2033641 ccgaacgcct ttcttcaagc aattttaatg ccaccgacgt tacatttctc gccttggcgg 2033701 ggatgccggc tcccgtccct aaaaaaagta attccacgtt tccttcctcc tactagaacc 2033761 agatacctac aagaatacag gatcaagcgg aaaatgtgaa tcttgcctct gaaaagaaca 2033821 atcctttcgt gctagaaaca ttttttcagc attctgctta aaaaagggct taaatgtttg 2033881 ctttcgttga attttagatt taaaatgaag gaaatatacg gggtgtacta aaataaagct 2033941 tcgaataaag tgaggtactt ttagtgaaaa caaaccaaca accaaaagca gtaattgtca 2034001 tattcggtgc aactggagat ttagcaaaac gaaaattgta tccgtctatt caccgtttat 2034061 atcaaaacgg acaaatcgga gaagagtttg cagtggtagg agttggaaga agaccttggt 2034121 ctaatgagga tcttcgccaa actgttaaaa catccatttc ctcatctgca gataagcata 2034181 tagatgattt cacgtctcat ttttactatc acccgtttga cgtgacaaac cctggttctt 2034241 atcaagagct aaacgtattg cttaaccagc tggaagatac atatcaaatt cctaacaaca 2034301 gaatgttcta cttggcaatg gctcctgaat tcttcggaac gattgcaaaa acattaaaat 2034361 cagagggtgt aacagctaca accggctggt cccgccttgt catcgaaaaa ccgttcggcc 2034421 atgatctgcc aagcgcacag gcattgaata aagaaatccg cgaagcattt acggaagatc 2034481 aaatttacag aatcgaccat tatctaggca aacaaatggt tcagaacatt gaagtgattc 2034541 gatttgccaa tgcgattttc gaaccgcttt ggacaaaccg ctacatttca aacattcaaa 2034601 tcacatctag cgaatcacta ggcgttgaag accgcgcaag atattacgaa aaatcaggcg 2034661 cccttcgcga catggtgcaa aaccatatta tgcagatggt tgcccttctt gcaatggagc 2034721 cgcctatcaa attgaacaca gaagaaatcc gcagcgagaa agtgaaggtg ctgagagcac 2034781 tgcgtcctat tgcaaaagac gaagtggatg aatactttgt gcgcggacaa tatcatgctg 2034841 gtgaaattga cggtgtaccg gttcctgctt atacagatga agataatgtc gctcctgact 2034901 ccaatacaga aacctttgtt gccggcaagc tcttgatcga caacttcaga tgggctggtg 2034961 ttccattcta catcagaacc ggaaaacgaa tgaaagaaaa gtccacaaaa attgtcgttc 2035021 aatttaagga cattccgatg aacctgtact acggtaatga aaacaacatg aatccgaact 2035081 tgcttgtcat tcatattcag cctgacgaag gcattacgct ttacttaaat gctaaaaagc 2035141 ttggcggagc agcacacgca cagccaatca aactcgatta ttgcagcaat tgcaatgacg 2035201 agttgaacac ccctgaagca tatgaaaaac taattcacga ctgtcttctt ggcgatgcaa 2035261 caaactttgc acactgggat gaagttgccc tttcttggag ctttgtcgac tctatttctg 2035321 aaacatgggc agcaaacaaa accttatctc ctaactacga atcaggctca atgggaccga 2035381 aagaatctga tgatcttttg gtgaaagacg gcttacactg gtggaacata taataagaag 2035441 aaaaaagccg aaaatgttta caagcatttt cggctttttt acgctgaaca aaggtataac 2035501 aatctcctta ataacaaaac ccccaaagct taagagcttc gggggtttct attgattact 2035561 tcatccattc agtatggaag atgccttctt tgtcagtacg ctcataagta tgagcgccaa 2035621 agtagtcgcg ctgtgcttgg attaagtttg caggcagtac ggctgtgcgg tagctgtcat 2035681 agtaggctaa tgcgcttgag aatgatggca ccggcacacc ttgggcaact gcaagtgaaa 2035741 tcacttggcg aagcgctcct tgatagcttt ctacaatatt cttgaaatag ctgtcaagaa 2035801 gcaggttgtc aagctcaggc tcgcgatcgt aagcttcttt gatcttctga aggaatgccg 2035861 cgcgaatgat gcaaccaccg cggaagatca tagcgatttc accatatttc agatcccagt 2035921 tgtattcttc agaagcagct ttcatttggg caaatccttg cgcgtatgaa cagattttac 2035981 tcatgaacaa cgcttttctg accgcttcaa tcagctcttc tttattttct gtaacaggct 2036041 tcacttctgg tcctgaaaga agtccgctcg cttttacacg ctcttccttc atagctgaga 2036101 taaagcgtgc gaatacagat tcagtaataa tcggaagcgg aacgcctaag tcaagtgcgc 2036161 tttggcttgt ccattttcct gttccttttt ggcctgcttt atcaagaatc acatcaacaa 2036221 gcggtttgcc tgtttcttcg tctttttttg tgaagatgtc agccgtaatc tcaatcaggt 2036281 agctatcaag ctcaccttta ttccattcag cgaaaacttc atgaagctca tcagcagaaa 2036341 ggcccagcac ctgtttcaga atgaaatatg attcagagat cagctgcata tctccgtatt 2036401 caattccgtt gtgcaccatt tttacgtaat ggccggcgcc gtccggaccg atatatgtcg 2036461 tacaaggttc tccgtcaact tttgcagaaa tggcttcaag aatcggtttt acaagctcat 2036521 gtgcttcttt ttgtccgcca ggcatgatag aaggtccttt aagcgctcct tcttctccgc 2036581 cggaaacgcc tgttccgata aaatgaatgc cgctttcagc gagttctttg ttacggcgct 2036641 gtgtatcttt atagtatgta ttaccgccgt caattaaaat atcatccttc tctagatgag 2036701 gaagaagaga ttgaattgtc gcatctgttg cagttcccgc tttaaccatt aataagattt 2036761 tgcgcggtgt ttccaaggat tggacaaatt cttcaatgct gtaagtgcca acaacatttt 2036821 ttccttttgc ctcctgtaaa aactcctcag ttttactgct tgatctgttg taaacagaaa 2036881 cagaaaatcc ccggctttcg atatttaaag ccagattttt acccatgacc gcaagtccga 2036941 taacgccgat ttgttgtttt gacatattct aacgtccctt ctgcaaacgt ttaatcattt 2037001 taaaatttaa attaaaataa aatgatattt ataataaaga aattaccata cattcaccct 2037061 ttttttcaag cgattcagct tttcttttca tcttgaaaaa aatctttatt aaagcttgtt 2037121 ccctttgttt tgctctcctc tttttttaac gttgcccctt ttctgatcag tttggtaccg 2037181 tactttttat tcagcttttc catcatctgc tgaatgggct catccttcgc atcttcatta 2037241 aagctgaaca aatcgagctg tttataggcc tgctcttttt ctactaaatc cgttccggta 2037301 atgccaagca gcctgacagg atttttattc caatgtttaa aaaagaggtg ctccgcttct 2037361 ttcaaaatgt catttttttg atcaatcggg tttctcagcg tagtgcttct tgtgatggtt 2037421 ctccaatccg catatctaat cataataaaa agcttcgaag ccatgacttc cttgcgctgt 2037481 aaacggtcac tcacagaagc ggcaagcttt ctaaaaacgc ctaacagctc ttcttcatca 2037541 ctggaatcat gggaaagtgt cgatgagttg ccgacgcttt taaattcgta aatgcgctcc 2037601 gggtcaaccg gcgcatggtg aatgccattt gctttatttt taaggcgcgg accgttgatg 2037661 ccaagcaggc gcttcagcga gtgttcatca gctgcagcta gctctccgat tgtatggatg 2037721 ccgagtccct tcagtttttc cgctgtcttt ttgccgactc cgtgcatctc tccaacagga 2037781 agcggccaca ggatatcggg cacttgcctc tttcttaaga tcgtaattcc aagcggtttt 2037841 ttcatatcag acgccatctt agcgagaaat ttattcggtg caatccctat gcttgacggg 2037901 agcagcagct ctttttgcag cctgctttgg atttcttttg ccgtctctag agcgcggctg 2037961 ctgtatggtg tatcggtcat gtccatatag ccttcgtcga tggagacagg ctccactagg 2038021 tcagtatatt cacgaagaat ggtaaacatc gctcgtgaag agtttctata gcggtcaaag 2038081 ttcggcggaa gaacgatgag ctcaggacaa tggcgcttcg cttgccaaac cggcatcgtt 2038141 gttttgacgc cgcgcgctct tgcttcgtag ctgcatgtta ccacaatgcc ctttcgctcc 2038201 tttacgtttc cggcaactgc gaccggcttt ccccggagag ccggatcata tgccatttca 2038261 accgacgcat aaaagctatt catatcaata tggaaaataa ttcggctctt tcccggcata 2038321 aacaaatctc cttttcggtc attagacaac agcttgtaca tatagtaaaa tgaagctatt 2038381 gaatggatgt gatgacaatg tttgtggaat cgataaatga cgttttattc ttagtcgatt 2038441 ttttcacaat tattcttcct gctctaacgg caatcgggat tgcattcctc ttacgggagt 2038501 gccgtgcggg cgagcaatgg aaatcaaaac gaacagatga acatcagacg gtctttcaca 2038561 ttaaccgaac agactttctt attattatat atcatcgcat tacaacttgg atacgtaaag 2038621 tcttccgcat gaattcgcct gtgaacgatg aggaagacgc cggttctctt cttttataaa 2038681 ccgcatttat aaaaaggagg agaacaaaat tgttaaaaac atatcaaaaa cttttggcta 2038741 tgggtatctt tttgatcgta ttatgctcgg gcaatgctgc atttgcagcg actaatcagg 2038801 tgggaggcct cagcaacgta ggttttttcc acgattattt aatcgaaccg ttttccgctc 2038861 tgcttaaggg tgttgccggg ctgtttcacg gagaatacgg actctctatt atcctcgtaa 2038921 ccattattgt gcgtatagtt gtattgcctt tgtttgtcaa tcagttcaaa aaacagcgca 2038981 tcttccaaga gaaaatggcc gttattaaac ctcaggttga cagtatccag gttaagttga 2039041 aaaagacgaa ggacccggaa aagcaaaaag agctgcaaat ggaaatgatg aagctgtatc 2039101 aggagcataa tatcaacccg cttgcgatgg gctgtcttcc aatgctgatt cagtctccga 2039161 ttatgattgg gctttattac gcgattcgct caacacctga aattgcgtca cactcgtttc 2039221 tatggttcag tttagggcaa tctgatattc tcatgtccct tagtgcaggg attatgtatt 2039281 ttgtccaagc ctatatcgct caaaaactga gcgcgaaata ttccgctgtc ccgcaaaacc 2039341 ctgcagcgca gcaatccgca aaattgatgg tgttcatctt ccctgtgatg atgacgattt 2039401 tctcgcttaa tgtgccggca gcccttccgc tgtactggtt tacaagcgga ctgtttttga 2039461 cagtgcaaaa catcgtcctt cagatgacgc atcataaaag taaaaaaaca gccgctctta 2039521 ctgagtcggt gaaataaaaa agcaaccccg tgcaaaaagc cggggttgtt ttttgttact 2039581 tgcaaagtac cgcgccaaac agtcttgttt atcatggctg aagcagaaat ggccatccta 2039641 aaaaatagcc gtatcgttta aaaagaagga aatcgggaat acctttactc acctccaacc 2039701 gaaaggagcc tatacgttga cggaacgctt tcagcaaaaa aatatttctg tacctgatgg 2039761 aatctggatc atgagacaaa cctggaatga tgtcttattt gctcactggc ctgttgatgt 2039821 ttctatcctt cgcgctttgg taccgtccgt tttagaatta gatacatata acgggcaagc 2039881 ttggatcagc atgcttccct ttatgctcac gaacctgagg gcgcgttatc tccctgtcat 2039941 tcccggtgcg cgtgcatttc ctgagcttaa cctccgcacc tatgtcacgt ataaaggcaa 2040001 gcccggcatt tattttttta gcttagatgc cgatcatcgt ctggcggtcc ttggcgctcg 2040061 cacattcttt catctgcctt atttttacgc ggatatgaag tccgaaaaaa acggtgatgc 2040121 cattgactat gtcagcaagc ggaaaaatga caaagaagca gcattccacg ccgcataccg 2040181 gccaatttca gcgcctttta cagcagaaaa ggattcgctc gattactggc tgacagaacg 2040241 atacaggctc tacaccactt atcgcaataa gctctattac gaagacatcc atcatcatcc 2040301 gtggctgctg caaaacgccg aagcagaaat ttcagtcaat acggtgactg atgctcacgg 2040361 tattacattg ccggagtcag accccttgct tcattatgct aaaaaacagg atgtgttatt 2040421 ttggccgctt aggaaatgga gctaaaaaaa cccgatgcgg gaaatcgcac tcgggttttc 2040481 tttttttatt ttgccgcctc ttcaataatg gcaacaacca tttctgccgt tttaacgagc 2040541 tcttcgatcg gcattttttc attttttgta tggatttgct cataaccgac agcaagattg 2040601 accgtcggga tgccatgacc agcgattacg ttcgcgtcgc ttccgccgcc gctcgtttgc 2040661 agctcgcttg gacgtccgat tttagcagcc gcttttttcg cgatttcaac aacttggtcg 2040721 ccgtcttgat atttaaagcc cggatacata acctcaattt cgacttctgc gcgtccgccc 2040781 atatcagcag ctgcctcttc aaaagcagct ttcatttttt gaacctgagc ttccattttc 2040841 tcaggaacta aagagcgcgc ttcagcaaga atatgaactt cgtcgcacac aatgtttgtt 2040901 tgtgtgccgc cttcaaaccg gccgatatta gctgttgttt cttcatcgat acggcccaat 2040961 ggcatttttg agatggcttt gctagcgatt gtaatcgctg aaatgccttt ttcaggttca 2041021 accccggcgt gagcggtttt cccgaaaatt gccgctctta ccttcgcctg tgtcggcgcg 2041081 gccacaatga tatttccgac ttttccgtct gaatcaagag catagccgta ggatgcagtg 2041141 atcatagaac ggtcaagcgc cttcgctccg atcagacccg attcttcccc tactgtgatg 2041201 atgaattcaa tcgtgccgtg ttcaatattt tcttctttca gcaccttaat cgcctcaaac 2041261 attgcagcca atcccgcttt atcatcagca cctaaaatcg tcgtgccgtc agttttgacg 2041321 taaccgttct ctacaactgg ttttacgccg tttccgggta caactgtgtc catatgagat 2041381 gtaaaataga tcgtatctgt ttgttttgtc ccttttagcg tgcaaatcag gttaccggct 2041441 ccgtggcccg tgatatccat tgtatcgtct tctttaacgt ccacacctaa atcagaaaat 2041501 tttcgtttca gcactttgca gatttcagct tcgtgctttg tttctgagtc aatttggaca 2041561 agctctaaaa attcttccag caggcgtttt tcattcacca tttgtaagtc cctccatatt 2041621 aaagcggtat gttaccgtgc ttttttttcg gtctctcttc tgtcttatgt gtaagcatat 2041681 gaaaagcttg aatcagtctt ccccttgatt cttccggcaa aatgatgtca tcgaccattc 2041741 cacaagcggc cgctttgtat gggccggcgt tttgcttttt gtattcagca gttttttcgc 2041801 gtttcgtctt ttgcgggtca gctgaagctt tgatttcctt ttcatacaaa atcgatgccg 2041861 caccttctgg acccatcact gcgatttcag cattcggcca tgcaaacaca aggtccgctc 2041921 cgatcgcttt gctgttcatg gccacatagg cgccgccgta cgcttttcta atgatgagtg 2041981 tgacttttgg gacagtcgct tcagcataag caaacaataa ttttgctcca tgcctgatga 2042041 ttccgttgtg ctcttgctga atacccggca gaaaccccgg gacatcttcg acagtcaaca 2042101 gcgggatatc aaatgcgtca caaaaacgga tgaaccttgc tgctttatca gcagcgtcaa 2042161 tcgtcaggct tcccgccaga tgcttcggct ggctcgccac gatgccgatt gctttttcac 2042221 ccagccttgc aaacccaatg acaatgttct tcgcaaaaaa tggctgaatc tcaaaaaaag 2042281 actgcgggtc agccagctcc ctaatcacct tccgaacatc ataaggcttt gtcgtatcag 2042341 cagggacaag acggtttaat aacggtctgg acgcctcttt ctctggcttc ggctctgttg 2042401 tccggccatt cagcggcaaa taagacagta gttttctcac ccctgtcaga acctccttct 2042461 ccgtatgccc ggaaaagtgg gcgtttccgc tgacggcatt atgtatcccc gctccgccta 2042521 agctctccgc atcaacctgt tcccctgtca ctttttcaat caccttcggg ccggtaataa 2042581 acatccggcc agtctgttca gccataaata taaaatctgt gagtgccgga gaatatacag 2042641 cgcctccagc gcacggccct aaaataaccg atatttgcgg aatgactccg gaatataaga 2042701 cgtttcggta aaatatgtga ccgtatccat ctaatgataa cacaccctct tgaattctcg 2042761 caccacctga gtcattcagc ccgataatcg gcgccttatt ttttgctgcc agatccatca 2042821 aagcgcagat tttcctggca tgggtttcgc caagcgcccc tccgtacact gtgaagtctt 2042881 gcgcaaatac ataaactgag cgaccgtcaa ttgtgccgta ccctgtcacg accccatccc 2042941 ctaacatgcg ctgttctctt gttaacactt gactttccat gaaggggtgt aattcgataa 2043001 agctgtcctg atctagaaga aatatgatcc tttcccgagc agtgagcttg cccttttgcc 2043061 gctgctgagc cagcttttcc cgtcctccgc cttcttctgc ctgcttgcgt ttcgtgtaaa 2043121 aatgatccat gtgctcattc atgctcattg tgttggtctc ctttcggttc acaaagctct 2043181 acaagaacac cgtttgtttc ccgaggggaa ataaacgcga tctttttccc gttcgctccc 2043241 tgtcttggaa acctgtcaat caattgaaca tgctgatcag acaatgcttg aagctgttca 2043301 gataggcagt tgcacaaaaa cgcaatatga tgcagtccct gccctttctt ctccaaaaat 2043361 aaatggacgg ggctgtcagc tgtcaacggc tctatcagct caagtttgac gctaccagct 2043421 tgaaaaaaag caacattcac cttttgctct tcaaccgttt cttgatgaag aaatgcaagc 2043481 cccaatacat tttcataaaa gcttcttgca tcttttatcg aaaaaacggc tatcccgata 2043541 tggtcaagcc tgttcatttt catccctgct ttcgctaata gatatcgctt gtccgcccat 2043601 tcaaaacacg ctaaaatata gacagattgt ttaaggagtg aaaatcatgt ctcaaaaact 2043661 gatgaaaagc gttttgatcg tgattttggg agtttttatt ctttcaactg tactctcagg 2043721 aatcgtcatg tttctataac gataaaaaag caggcgcctt attcaatggg aatatcctgc 2043781 ttttttatca gagctttatg ctcgatggca atctcctcaa aagagcggtt gtcgtccgtg 2043841 atcagcactc tcgttcctac tggtatcgtt tgaaacaaat gaacaacctc atcgttatgc 2043901 atacgtatac agccgttaga cacaaatttt cctactgatt cctctcggtt tgtcccatga 2043961 attccataaa tccgcccgtc cgttcctttc gcgtcaaatc cgatccatct tgccccaagc 2044021 gggttatcag gagatccccc ttcaatattt ttctttctgt agtaaggatt ttccgctttt 2044081 accgttaccg aaaactctcc ttcaggcgtc aaatcatctg tttttccagt cgccacacta 2044141 tacacgcctt ctactttgtt gtcgaggata acagcaagtt catttgttcg cttgttgaca 2044201 ataacatacg gatcacccgg cagcggattt tcgccgagcg gccaaatcgg tgaaatcatc 2044261 atgaaaatcg aacataagaa aaaacgcata agctcctcct ttttcattag gttgaccaat 2044321 gaaggaagag ctcatgcgaa tcatccgagt gatttttgcg cttttattcc tttaaaataa 2044381 cttttaatca ctaaatattg ttccatttcg ccgagaagat ggaagagagc ggccctcgct 2044441 tcaaattcct ctctagtcgc aggaagcggc atctcctcaa attcttttct catgtcagca 2044501 agtcttttca gaaatttgta tgctgtattc ccagggtgta tcgcctcccg caaatcatga 2044561 ataaattcag cgatcatttt tccctgatct accgtgatgg agatcgatgt cactttaggg 2044621 agaaggcgtt cgataatttc aaattgcttt tctctcattt taaaataatg ataatgcaga 2044681 ttttcataac gcaaaatgtg gttttgcaca tctcgatatg ccaggttttt agcctccgta 2044741 atgagctggt gcgtttccgg aatttctttt cctgaccaat cttgctcacc agttaacaaa 2044801 taccgttcga tttctgcaaa aatgacagca aagttatcct ctatcttttt gcggtaggca 2044861 atcagtttcc ggtcaagact aggcatatac aagttcatca atagagcgac gccgatgcca 2044921 accgtaatca gctgaacttc attccagatg aaagtaggcg taatgccgcc ggacatgtat 2044981 aaatgaagga taataacaga actggtgacg ataccctcgt taatttttaa cagaaccgtt 2045041 atcggaatga atatcaaaag aagcgctccg atcacaaacg ggtggtagcc aataagctcg 2045101 aaaaagagat aagaaaaagc aattgccaga cagcatgccg aaaagcgggc ccatgaggcc 2045161 tgaagcgacc gtttttgtgt gatttgtatg cacaaaatgg tgatgattcc tgctgatgcg 2045221 aagttttgca aatgcaataa ctggcttata taaatagcca aagctgttcc aagcgcggtc 2045281 tttattgtgc ggtaaccaat tttaaacatg tcggactcca tttctatttg tttcttcaat 2045341 aaaaaagaag aggcggccag ccttcttctt ttttatattc tataatattt tctctaaaaa 2045401 gtcctgcgct cttttggatt ttggcgacat aaaaaattcc ttcggattgc cgtcttcgac 2045461 aatcattcct tggtccataa acagcacacg gtctgccact tcttttgcga agcccatttc 2045521 atgtgtgaca atcaccatgg tcatgccggt ttcgaccagc tctttcatca cctgtagcac 2045581 ttctttgacc atctctggat caagggcgga ggtcggctcg tcaaacagca tgatgtccgg 2045641 attcatcgca agagccctgg caatcgcgac acgctgtttt tgtccgccag acaaacggtt 2045701 tggatagtca tttcgctttt caaacaaacc gactttgcgg agcaggtcct cagctttctc 2045761 ctgtgcagcc tgttttgatt ctttttttac attgacaggc gcgtacatga tgttttcgag 2045821 aaccgttttg tgcggaaaga gatgaaaatg ctgaaaaacc atcccgatgt tttcccggac 2045881 ctttaatgtg ttggttttcg gcttcgtaat ctctgtgtct tttattgtaa tggttccgcc 2045941 gttaggcttt tccaacaggt ttaaacagcg taagaacgtt gatttgcctg agcctgaagg 2046001 accgatcacg gcaacaacct caccctcagc gattgttgtt gaaatgtttt ttaatacttc 2046061 gtgtttccca aatgattttg acagcttttc aaccttaatc attggatttc agcttccttt 2046121 ctacagcctt gccgataaac gttaaaatca ggacaagcac ataataaatc aatcccgcga 2046181 taatgagcgg ctcaaggtaa ttgtaagtgg cggcgccagc ttgatatgcg cgtctcatga 2046241 catcaccaag cccgatgacg gtgacgatcg ccgattcttt tgttaacgta attaattcat 2046301 tcacaattgc aggtgatata tttttgaagg cctgcggcag cagcagatcc ttcatcattt 2046361 ttccatacgg gacaccgagt gcaacagcag cttctttttg ccctttatca atggcattga 2046421 ttccggctct gataatttcc gatacataag cggcggaatt caaagacaat gcgacaaccg 2046481 cagcccaaaa ctggtcaatt tgaaatccga gcagctgagg aaggccaaaa tagacaatca 2046541 taagctgcag cactaaaggc gtgcctcgga acactgatgt ataaaaatca gcgatccaga 2046601 taaacgggcg gaatgtgctg atcttgcata agcttagcac aataccgagt ataagtccga 2046661 taatagcaga tacaacaaca atttttaatg taattgccaa gccttctaat ataaaaggaa 2046721 tttgggggat cgttgctgaa aaatccaaat tcatagcctt tgtctccttt tcttacagga 2046781 aaaaagtttc ctattcaata aaaaggctca acgaaaaagt tgagccgctt ttttttactt 2046841 ctcgccagtg aaccattttt tcttcaattt ctcaagctct ccgttatctt ccatttcctt 2046901 gagcgcttta ttgaatttgt ctgtcagttc actgtccttt ctgaaagcaa ttgctgaacc 2046961 ggcttcttcc gctttcgcat caggaatcac aaagccttgc aggtcatcat ttgatttgaa 2047021 atacccttct gcaacaatgt cttcaataat cgcggcatcg aagcggtcag atttgatttc 2047081 ctgcaccaaa tcagaaattc tgttgcggtc ttctgtttta aaaccatatt ccggagaaag 2047141 ctctttcccc ttctcttcct gaatagagcc aagctgaacg ccaactgttt ttcctttcag 2047201 gtctttcaaa gattgaatgc cgctgtcttt tttgctgaca atcatatggt tcgctgtgta 2047261 atacacatcg gaaaaatcaa cttgtttttt acgctcaggc gttggtgtca ttcctgacag 2047321 aacgagatcc acctgttttg atttaagcgc tgtaattaag ctgttgaagt ccatatcctg 2047381 cacttcaatt tcatagcctg ccttctttgc cagagctttt gccagctcta catcaaagcc 2047441 gacaatatta tctccttctt tatattcaaa cggtttgtaa tccgccgaag tacccataat 2047501 taattttttc tttccgcttt ctgaacctga attgcttgag ccgcacgcag ttaatgcaaa 2047561 ggtgatgcaa gcagccacaa gtaataagag ccattttttc atgatccatt tcccccgtat 2047621 tcattacttt tggtgtattt gaatatttat tcgttaattt gtattttaaa cagtttctca 2047681 tttttatgca atactatttt taaaaattat ctttaggctt atctttccag tgatctcttc 2047741 tgatattact agataaaaat taaatcgctg tacaatccga ttgaataatc ccttaatatt 2047801 tattcatata tccttggaaa tttatgcaca aaaaaacccg ggctgctttg agcatccggg 2047861 ttgttcgtct tatacttctt cacaatattc ttcaaaggct tcctgcagct ttgccactac 2047921 agccatcggc tcatggcctt caatttcatg acgctctacc attttcatga tctttccgtc 2047981 tttcaaaatc gcaaaggacg gagaagatgg tggataacct tcaaaatagt cacgcgcacg 2048041 cgctgtcgct tctttatcct gtccggcaaa aacggtgacg agctgatcag gtcttttatc 2048101 atagtgaacg gaatggtagg ctgccggtct tgcaattcct ccggcgcatc cgcaaacaga 2048161 gtttaccatg acgagcgtcg ttcctttttt cgtaagtgcc tcatccacct cttcggctgt 2048221 tttaagctcg gtgtatccgg cagctgttat ttcttgtctc gcttggcgga caatatcatt 2048281 cataaataaa ttaaagtcca tgttcaatga agacctctcc tttttcatca tctgttctta 2048341 tgatagcaag gaaacgtcca tatcggcaaa tgactttgct tcgccgtgca ctttttttgc 2048401 tcttcgttta ctgcttacag aaaaagggga ttatataacc agaagtaaaa taaaggagca 2048461 gttgtatatg agccaccgga aagcgttact gattcataac ggaaatgccg gcaacaaaaa 2048521 tatagaaaaa gcacttggtg ctgtggtgcc ggttttatct caccatttag atgaggtgat 2048581 tattaaacag acaaagaaaa aggatgatgc gtatcatttt tgccgatcca ttgatgattc 2048641 tgtcgacacc gtcttcattc tcggcggcga cggcacgatc catcaatgca taaatgctat 2048701 cagcgctcta gaaagaaaac ccgctgtcgg aattttgccc ggcggcacgt gcaacgactt 2048761 ttcaagagtg cttggcatcc ctcaaaatct tgcaaaggcc gcggaagcac ttatggcggg 2048821 aaaaaaaacc agcgtagacg tatgtcagat gaatgaccgt tattttttga atttctgggg 2048881 gatcggctta attgcagaaa cgtcgaatca aatcaacgaa acggaaaaag cattattggg 2048941 aaaaatcagc tattttacaa gtgccttgcg aaccgtctca tctgctgcat cgtttccgat 2049001 gacattaaaa attgatggag aagaaattaa agaagaagcc gttatgctgc ttgtgatgaa 2049061 tggccaatac attggaacga atcgaattcc tctgcccgat gccagtattg aagacggctt 2049121 acttgatgtt ctcatatgcc gcaataccaa cctcaccgcg ctgcgggagc tgatgagcat 2049181 ggaacaaggc tcaattgatc gttttactgg agagttgtcc tatgtccagg cttcccgtat 2049241 cgagattgaa acagacactg ccaaaaaggc ggatatggat ggagaagttt atacacatac 2049301 acccgcagtc attcaggtcc tgccacagca tatcgacatg cttgttcccg caaatgaata 2049361 actgtcataa ggctttagaa agattttgca aatccgttga ctctccccta ggaggaggtc 2049421 ttacagtata agggatacac acttgaaaaa ggggaagtca tatggagaag aaaaatatta 2049481 ccttaactat attattaacc aatttattta ttgctttttt ggggatcggg cttgtgattc 2049541 cagtaacgcc gaccattatg aatgaattgc atttatcggg gaccgcggtc ggctatatgg 2049601 ttgcctgctt cgctattaca cagctcattg tctcaccaat agccggacga tgggttgatc 2049661 gcttcgggcg caagatcatg atcgtaatcg gcctgttgtt ctttagtgtg tcggagtttt 2049721 tgttcggcat tggaaaaaca gttgagatgt tatttatctc ccgtatgctg ggcggtatca 2049781 gcgcagcctt cattatgccc ggggtcacgg cttttattgc agatatcacg accattaaaa 2049841 cacggccaaa agcgctcggt tatatgtcag ccgctatttc aacaggattt attatcggcc 2049901 ccggcatcgg gggattttta gcagaagtcc attcccggct gccttttttc tttgcggcag 2049961 cttttgcact gttagcagcc attttatcaa tcctcacgct gcgcgagccg gaacgaaacc 2050021 ctgaaaatca ggaaataaaa ggacagaaga caggctttaa acgaattttt gcccccatgt 2050081 atttcatagc ttttctcatt atcttaattt cgtcttttgg tttagcatca tttgaatctt 2050141 tatttgcatt attcgtggat cataaattcg gatttacggc cagcgacatt gccattatga 2050201 ttacaggagg agcgattgtt ggcgccatta cgcaagtcgt cttattcgac cgcttcacaa 2050261 gatggtttgg cgaaattcat ttaattcggt acagcttaat tctctcgacg agtctggtat 2050321 tcttgctgac aacggtacat tcatatgttg cgattctgct ggtgacagtc accgtatttg 2050381 tcggatttga tctcatgcgg cctgcggtaa cgacttacct gtcaaagatt gcgggaaatg 2050441 aacaggggtt tgccggcggt atgaattcaa tgtttacaag tatcggcaat gtattcgggc 2050501 ctattatcgg cggaatgctg ttcgatatag atgtaaacta tcctttctac tttgcaacgg 2050561 tcaccttagc catagggatt gcactgacca ttgcttggaa agcgcctgca catcttaaag 2050621 ccagcacgtg ataagaagcg cattctttgt gtactgcaaa gaatgcgctt cttctttata 2050681 ctgatgatag aaggagtgat ggcatgaagg aatcgtatta ctcaattggg gaagtatcaa 2050741 aactggcaaa cgtgtcgata aaagcgctcc gttattacga taaaattgat ttatttaaac 2050801 cagcctacgt cgacccggat accagctacc gctattatac agattctcag ctcattcatc 2050861 tggatttgat caaatcattg aaatatatcg gcacaccttt agaagagatg aaaaaagcac 2050921 aggacttaga gatggaagaa ctgtttgctt tttatacaga gcaggagagg caaatcaggg 2050981 agaaattaga ctttttatca gccctggagc aaaccatttc attggtgaaa aagcggatga 2051041 aacggcagat ggaatatccc gcgctcggtg aggtgtttgt tttagatgaa gaagaaatac 2051101 ggatcattca gacagaggca gaaggaatcg ggcctgaaaa cgtgctcaac gcctcctaca 2051161 gcaaattaaa aaaatttatc gagtcagcag atggatttac gaacaatagc tacggcgcta 2051221 ctttctcttt tcagccctac accagcattg atgaaatgac ttaccgtcat attttcacac 2051281 ctgtattgac gaataaacag atttcatcaa ttacgccgga tatggaaatc acaacgatcc 2051341 ctaaagggag gtatgcgtgt atcgcgtata atttttcgcc tgaacattat tttctcaact 2051401 tacagaagct tatcaaatat atcgcggacc gccaattaac agttgtcagt gatgtatacg 2051461 agttaatcat accgattcat tactccccga aaaaacaaga agaatatcga gtcgaaatga 2051521 aaatacggat cgctgaataa taaagcatag aaaaagagca ttttttgaaa caaaacttca 2051581 aaaaatgctc tttttgctta tttagtaaac agatgtcttc tcgtcaatcg attctaaaat 2051641 ttgtttcact cgtccgagga atcgtccgca cacgagaccg tcaagcactc tgtgatctaa 2051701 tgacaggcac agattaacca tgtctctgac agcaatcatg ccattgtcca tgacaaccgg 2051761 gcgtttgacg atggattcta cttgaagaat cgcagcctga gggtagttga taatgcccat 2051821 cgactgaaca gacccgaacg aacctgtgtt gttgacggta aacgtgcctc cctgcatgtc 2051881 atctgcagtg agttttccgt ctcttacttt tttagctagg ccggtaatgt ctttcgcaat 2051941 gcctttaatt gttttttcat cagcgttttt aatcaccgga acaaataaag aatcctctgt 2052001 ggcaactgca attgaaatat tgatatcctt tttctgaata attttgtccc ccgcccacat 2052061 gctattcatt tgcgggaatt cttttaacgc ctgagcgacc gcttttacaa aaaaggcgaa 2052121 gaacgttaaa ttaaagcctt ctgtcttctt aaaagaatct tttatactgt tgcgatatgc 2052181 aaccatattt gtgacgtcga cttccatcat cgtccaagca tgcggaattt ctgttttgct 2052241 tcgcttcata ttggaagcaa ttgcttttct tacacctgtg acagggattt ctttatcacc 2052301 ggctgcagac gcaggatatg acgtctcttc ttttggctca ggttttgatg cagacttcgg 2052361 tgcaggagct gctgttttca gctcctcagg attctgttct tgcacgccgc ctgtttcaat 2052421 taagcgctga atatcttttc gtgtgatgcg cccgccggca ccagttcctg tcacttgatc 2052481 gaggtcaatg ccgtgctctc cggccaaacg gagaacagct ggcgagtagc gctttttatt 2052541 gggctgatcg gctgctccag cactttttgc aacagggttc tcagcggctt ctgatgctgc 2052601 tggctgttct tgtttttgtt cagccggatt cgcgccttct gtttcaattt tgcaaatcat 2052661 ttctccgact tgcagggttt ggccttcttc tcccacaagc tctgttatcg taccagtaaa 2052721 agaagacgga acctctgcat ttaccttatc tgtcatgact tccgcgatcg gatcgtattt 2052781 gttcacttta tcaccggggg cgacaagcca tttgctgatc gtcccctctg ttacgctttc 2052841 tccaagctgc ggcatcgtca tttgttcaat tgccatgatt gtatcctccc ttacgtcttt 2052901 aaaactccgc taattctctc atcgccgctt ccactttatc agggttgacc ataaagtatt 2052961 tttccattgt cggcgcataa ggcatagccg gaatatcagg acctgcaagc cgtttgatcg 2053021 gcgcgtctaa gtcgaacaga caatgctcgg atataattgc ggctacttcg ctcatgatgc 2053081 tgccttcttt tgtatcttct gtgaccaaaa gaacctttcc agttttggac gcagcttcga 2053141 tgatggcttc tttatcaagc gggtaaactg ttcttaaatc caccacatgc gctgaaatgc 2053201 catctttttc gagacgttct gcagcttgta aggcgaagtg gacacacagg ccgtatgtga 2053261 tcactgtgat gtcgtcgcct tcccttttta cgtccgcctt gccgattggc aggacataat 2053321 catcagccgg aacctcgccc tttatcagac ggtatgcccg cttgtgctca aaaaacagca 2053381 cggggtcttc gtcacgaact gcggctttta agagcccttt cgcgtcatat ggtgttgatg 2053441 gcatgacaat tttcagtccg ggctggttgg cgaaaattgc ttcgactgat tgagaatgat 2053501 acagggctcc gtgcacgcct ccgccgtatg gcgctctgac gacaatcgga cagctccagt 2053561 cattgttgct gcggtagcgg attttagccg cttcagaaat aatttggttg actgccggca 2053621 taatgaaatc agcaaactgc atttcagcaa tcggtctcat tccgtacatt gccgctccga 2053681 taccgactcc tgcgattgca gattcagcaa gcggcgtatc cataacgcgc tcttccccaa 2053741 attgttcata gagtcccgct gtcgctttaa acacaccgcc ttttcttcct acatcttccc 2053801 caaggacgaa aacgcgagaa tctcgttcca tttcttcttt catcgccaaa ttgattgcat 2053861 caatatatga cattactgac atttgttctt cctccctact tcgcataaac ataatcaagc 2053921 gctgactcag gagctgcata tggggcgttc tccgcttcat ccgtcgcttc atttacgatt 2053981 gccataattt catccagcat ggtttgttct atctcatcgg acagcaggcc tgtttccttt 2054041 aagtaagctt gataagtaag caggggatca ctttttttcg cttcctctac ttcttcacgg 2054101 cctctgtagc tgctgtcatc gtcatcactg gaatgtggtg taaggcggta agaaatcgtt 2054161 tcaattaatg tcgggccttc tcctctgcgt gccctttcgc gtgcttcttt aaccgcttga 2054221 taaacttcca gcggatcatt tccattcaca gttacgccag gcatcccata gcctatggca 2054281 cggtcggaaa tgttctcaca tgcgacttgc ttatcgtaag gcactgagat tgcgtatttg 2054341 ttgttttcac acatgaaaat aaccggcagc ttatggacag cggcaaagtt tgccccttca 2054401 tggaaatcgc cttggtttga agacccttcc ccgaatgtaa caaaggctgc gatatccttt 2054461 ttctccatac gtcccgcaag cgcaataccg actgcgtgcg gcacttgcgt tgtaaccgga 2054521 gatgatcccg tcacaatgcg gtttttcttt tgtccgaaat gtcccggcat ctggcggcct 2054581 cctgagttcg gatctgctgc ttttgcaaac ccggacatca ttaagtcctt tgctgtcatg 2054641 ccaaacgcga gcacgacacc catgtctctg tagtacggca atacataatc catttcacgg 2054701 tcaagtgcga aagccgctcc tacctgtgct gcttcctgtc cttgacaaga gattacaaat 2054761 ggaattttgc cagaacggtt taacagccac attctttcat cgatttttct tgctaacagc 2054821 atggttctat acatatcaac ggcttcctga tcagtcagcc ctagtgcttg atgtcggttt 2054881 gtactcattc aagcccctcc tttatgcttt taaaaatgaa tggctttgcc atctgcggca 2054941 agcgcagctt ctccaattgc ttcagaaagc gttggatgcg ggtgaatcgt ttgcccgacc 2055001 tcccacggtg ttgcgtccag cactttggca agacccgctt cagaaatcat gtcggtgaca 2055061 tgcgggccaa tcatatgaac gccgagaata tcatctgtat ctcggtcagc cacgattttg 2055121 acaaaaccgt cgctttcacc gtatacaagc gcttttccaa tcgccataaa tgggaacttg 2055181 ccgattttga cattatgccc gttcgccttt gcttcgtctt cggttaagcc gacactggca 2055241 gcttcagggc ttgagtaaat gcacttcggc acaagcgtcg gatcaagcgg atgcggattg 2055301 agacctgcaa aatgctcaac agcaataatt ccctcatgtg aagcaacgtg agctaactgc 2055361 aggccaccga ttacgtctcc gattgcataa atatgagatt ccttcgtttg gcagctttca 2055421 ttgactgaaa tcatgccatt ttcagtaaca atatcggtgt tctctaggcc gatgccttcg 2055481 atatttgcct gtctgccgat ggaaacaagc attttctcag cagaataggt aacggtttct 2055541 ccgtcttttt ccgcttgtat gctgatatcg tctgatgttt ttgtcattgt gtcaggcagc 2055601 acttttgccc ctgttatgaa ctggatgcct tttttcttaa gaagactttc catttctttt 2055661 gaaatctcta gatcttcagt cggcaatatg cgatccgcgt attcaataac cgttacctta 2055721 acgccaaaat catgaagcat agacgcccat tcgataccga taacccctcc gccgacaatg 2055781 atgattgact gtggcagctc ctccatttgg agcgcctcat ctgaagtcag tacagactta 2055841 ccgtccactt caagacccgg aagcattctc ggtcttgatc ctgttgcaat gatcacttgt 2055901 ttcgggatca gcatgtcatt ttcttcgcca tttccccgct caacagaaat tgttcccggc 2055961 agcggagaga agattgacgg tccaaggata cgtccatatc cggtgtacac gtcaattttt 2056021 ccttttttca ttaaatgatt tacacccgct gcaagcttat caacaacggc ttgcttacgc 2056081 tgctgcactt tttcaaagtt gagggacacg ccagccgttt ccactccgaa ttgatcggct 2056141 tcacgagctg tccggtatac ctctgcgctt ctaagcagcg ctttactcgg gatacagcct 2056201 ttatgcagac atgttccccc gagtttttcc ttttccacaa cggctgtttt taagccgagc 2056261 tgagcggctc tgatggccgc aacataaccg ccggtaccgc cgcccagaat gactacgtca 2056321 tactcagttg ccatggtgac tcactcctgt ctgtctattc aatacgatat tgtttggatt 2056381 gctcttcgcc ctgcaatact cttagcgccc cttgggcaag agactgcagt tcattttcac 2056441 ccggataaac taaaacgtct gaaatccaat ctatgtatga tctgatagca gaaacaaagc 2056501 tttttccgta cgcaaggcct cccgtcagca caatcgcttc aacttcgcct tttaacgccg 2056561 cgctggctgc cccgatttcc tttgctacct gatatgccat ggcatcataa atgaagcggg 2056621 ctttttcatc gcccccttga atcatctgtt ccacttttac tgcatcattt gtaccgagat 2056681 agcctaaaag tccgccggtg ccaacaagct ttttcatgat ttcttctttt gtatattccc 2056741 ctgaaaaaca tagatcaaca agatctcccg caggcactgt tcctgctcgt tcaggactga 2056801 atggtccctc gccgtgcagg ccgttattga catccaccac tcgcccgcgg tcatggacgc 2056861 caattgtaat acctccgccc atatgggtaa taatcatttt catgttctca tatcgtttgc 2056921 caagggaggc tgccgcttta cgagcgacag ctttttggtt taacgcatgg aaaatgcttt 2056981 tcctttcaat ttcaggcatg cctgaaactt tcgcaagcac tgacatttcg tctacgacaa 2057041 cagggtcgac gatatacgaa gggatattca ggccgtcagc gatttcccgc gcgataatgc 2057101 cgccgagatt agaagcatgc tgaccggcgt agccgctttt caaatcctca atcatctcat 2057161 cattcactac gtaggtcccg ccttcaattg gccggagaag gccgcctctt gcgcagactg 2057221 catcaaactt tgaaatattg attccctgtt catgaagcgt ttcgagaata tggtttttac 2057281 gaaattcata ctgatcaata attcggtcaa atcgctgcag ctcttctatg ttgtgtctca 2057341 atgttttttc aaaaatgctt ctttcgttat gaaaaacacc gattttcgtt gaagttgagc 2057401 ctggattaat tgtgagaatg cgtttttcgt catgtagcac tttcataacc tccagatcaa 2057461 tttcttaacg tctgcttaat acactgtggc cgttttgcaa aaactggctt cttgagcggc 2057521 gcatgcgttc aatccgttcc tctgctaagc ggtcagccgc taaatatgca ggaatgccgt 2057581 cacgctgaga aatctcaagt acacgctcga tattgccgta aatgccttca acttttttca 2057641 atgcacgttc tgcattatag ccgtaaagct catctgccac gttgatgaca ccgcccgcgt 2057701 taatcacgta atccggtgca taaacgatgc ccatttcgtg aatttgatca ccatggcgtg 2057761 tctcttttaa ttggttgtta gccgcacctg cgatcacttt cgccttcagc tgtttaatgg 2057821 tgtcgtcgtt aatagtcgca ccaagggcac acggcgcata aatatcgcag tcttgtgaat 2057881 aaatgtcatc aggatctacc gcacgggcgc caaaatcttc aactgcacgc tgtacagatt 2057941 gtttgttgat atccgtaacg attaagtttg ctccttcttc atgcaggtgg cggcaaaggt 2058001 tataggctac gttcccaaca ccctgtacag caatggtttt tccttcaaga gagtcggttc 2058061 cgaaagcagc tttagctgct gccttcattc ctctgtacac cccgtacgct gtgactgggg 2058121 acggatttcc agaagagccg aaagcaggag aaatccctgt gacatagtct gtctcatcat 2058181 gaatgatatc catatcctcg accgttgtgc ccacatcttc agccgtgatg tatctgccat 2058241 tcagtccttg aatatagcgg ccaaacgcgc ggaacatttc ctcatttttg tctttgcgcg 2058301 gatcgccgat aatgactgtt tttccgccgc caaggtttaa gcctgccgcc gcgttcttat 2058361 aggtcatgcc tcttgccaat ctgagcgcat cttcaattgc cgcttcttca ttttcatatg 2058421 tccacattct cgttccgcca agcgccggac caagcgttgt atcatgaatg gcgataatcg 2058481 cttttaatcc agattgttca tcctggcaga ataccaattg ttcgtaatcg tatttctcca 2058541 tatatttaaa aagttccatg ttcgttcctc ctaatgtgtg tattcttcag atgcgcatat 2058601 tgccagcgca atggaataca gtttattttc agcagagtcc gctctgcttg ttaaagcaat 2058661 cggtgctttt gctcctgtaa tgacagccgc cacgctggcc ttggcaaaat aaatcagtga 2058721 tttatataaa atattgccgg cctcaattgt tgggacgaga aggatatctg cgttgcccgc 2058781 tacgtctccc gaaatttttt tctgggccgc ggcaatttgt gaaactgcgt tatccaaagc 2058841 aagcggtcca tcaacaatgc agcctttgat ctggcccctt ttgtacattt gagctagagc 2058901 agctgcattc acggtcgctt ccattttagg gttcaccgtt tcgaccgctg caagggcagc 2058961 tgcttttggc atattgttcc ccactgcatg ggccacatga acggcatttt gcaaaatctg 2059021 ccggagctct tccagcgaag gagcaatatt cattgccgaa tctgtcacaa acatcagccg 2059081 gtcaaaatcc ggtatatcga agacagccac gtgagaaagg acacttgctg accgaagccc 2059141 ctcctgtctg ttcaataccg ctttaagcaa aacagaagtc ggcacattgc ctttcattaa 2059201 aacgtccgct gttttatgat gcacagcacg aaccgctaat ttcgccgatt cctcaggagt 2059261 attggcatgg acgatttcca cttgatgccc ttgcatggat gatgtcagct cgttcagttt 2059321 tttgctgtcg cccgttaaca agaaacgggc ggataggtgc tcggctgcca gctttacagc 2059381 ccggatcact tcctcatcct cagcatgagc aaccgcaatg gtcttatttt tgtgtatcga 2059441 cgctttgccg attaaatctt tcagcttcat ctgttaccac ctttcttgtt tcgactccgc 2059501 cttttattat gcaagttcca tgccagctct taagggtgct gtcataccag gtataccgaa 2059561 acattcgtgc agatgtttgc gtttattctg caaattattg catgccttca tttgcaaggc 2059621 catatttatc cattttgtaa tataaattcc gaatgctgac accgagagct tttgctgttt 2059681 ttgtccggtt aaaatgatgc ttttcaagcg tttgctggat caaatgcgct tcaaattttt 2059741 ctactgcgac agacagcttt tcgccttcaa tatccggaaa atcaaaacct gttccctgat 2059801 ctgtgtcatt ttctttttgc tcaagttcga atacaggcaa gtgatctttt tcaatccatt 2059861 ccatatgcgg attcagaaaa atcatggctc gtccaaggac attttcaagc tcccggacat 2059921 tcccaggcca atggtaggca gataaggcgc gcaaggcttg ctgtgagagc ccttttacat 2059981 tcctgccgta atcccggttg atcttttgga taagtctgac gctcaatgct tcaatgtcct 2060041 ccaaccgctg ccgcaaaggc gggatggaga tcggatagcg attgatccgg taatacaggt 2060101 cttcccggaa tgttccgtcc gccatcgcct tttcaatatt tacatttgtc gccgcgatca 2060161 ctctgacgtt gacagggatc gctttcgtgc cgcccactct gacgatttcc ttttcttgaa 2060221 ggacgcgtag caatttggcc tgcatatttt gtgtcagctc accgatttca tctaagaaaa 2060281 tactgccgtt atttgcttcc tcaaataaac cctttttacc gccgcgcttc gctcctgaaa 2060341 acgcaccatc ctcatagccg aacaattctg attcgagcag gttttcagaa agggctgcac 2060401 aattcacgcg aataaattta ttgtatttcc ggtcactttc gttatggatg gcatgggcga 2060461 acagttcttt tcctgttcct gattccccgc gcagcaagat ggttgccggt gttttcgcac 2060521 cgagcttcgc ctgctcaagc gcaaccagca tttgctcgct tttgccgata atgtcgtcaa 2060581 acgtgtattt cgcttcaagc gtgcgaataa tttgtctggc gcgattaagc tccgctgtca 2060641 gcattttaat ttcggaaaca tcgtgaatca cgccgacgct gcctttcaaa atcccgtcca 2060701 caatcaccgg tgctacatta acgatcactt ctttttcatt cgggccgacc ttcattctga 2060761 caccgcggac aggacgtctt gtttcaagca cctttaaatg catgctttcg ccttcggaaa 2060821 tatcagtgtt tgcaggcttg ccgatgactt ctttttcaga aagccccgtc attttcgtat 2060881 acgctttatt gattagcagg ccgatgccgt tttcatcaac gacagaaatc gcctcatcgg 2060941 aggattgaat aattgcctcc agcatcgtac ggacctgctt taagttggtc acttcctctg 2061001 ccagctcgac cgcatcagtg atatctttaa acacacaaag agccccgagc agacgtccgc 2061061 cttcatcaat aatcggcagt cttgtggtca caatttgcaa atgatcgcct aacagctgct 2061121 tctggttgta ttcaggcact cttgttttta aaatccgcgg catcttagtg ctcggaatca 2061181 cttcttttat tgggcgccca atgacttcct cacgtttttt tccgaccatt ttttcggcca 2061241 tatggttaaa gagaatgatt tcttcattga tatcaataaa aatcattcca tcatgggtgg 2061301 aattaaaaat tctgtcatat ttataggttt gctcttttag catttgaatc aggtgctgct 2061361 tttcttccat cagctgaaaa acgatgtatg ccatttttcc cggcatgaca atggtatctt 2061421 catgctttct ttgaaggagc tcgtcaaaca cggcttgatc gccggtagta tgaatgacga 2061481 tatccggttt ttgttgtatg taaggtttcc aatcagatga tacggcaatc ccatactgtt 2061541 ctgcttcttt caatcccggc gcctcggggt ctttgtcaac tacggcaatg atatctatga 2061601 tggctgtttt aatcagaata tgtaataacg ccgttcccct tttgccggca cctactatca 2061661 gtaccttttg catcccgata cccctttgta tgaaaaaatt tgcacaccta tttattccgt 2061721 tgcaataatt tgcacaaccc tatgttacca cgttttcttc tcttgacaaa atattttttc 2061781 cgctggacaa taaaggaaat gaaaagataa aggggttttc tgaagatgag ccgacttctt 2061841 gcgcttttaa tattagtcat ccccggggct atttctgctt taggcattaa actgatgaga 2061901 gatacacttt tcggccatac aatcaagcca ttttcagctc tttggctcca agggttgtca 2061961 ggattcatct tttttgcgat cggcctctat gtgctggccg ggttcatttt atacagagac 2062021 agaaaacgca atcaagtcag cccgcgattc agaaaacgat agctgaaaaa aagccggaga 2062081 atgctccggc tttttttgtt gcattattcg tcaggcaaaa cggtcttggc aatcgttttg 2062141 tctaacgctt catagtcata ataagaaatc gtatcgtaca gttcttttcg tgtctgcata 2062201 tcatgaagtc cttctttttg tgagccgtgc tccttcatca aaccaaacat ccgctcacaa 2062261 gcttttgccg ccgctcgaag cgaggtgaca ggatatatca ccatgtgaaa ccccatatct 2062321 tcgaattcat cggcacgata atatggcgtt ttcccaaatt cagtcatatt cgcaaggagc 2062381 ggaacgggga tacgctcagc aaactggcgg aattcattct ccgcctgtag cgcttccggg 2062441 aaaattgcgt ccgctcccgc ctcaatgtaa gcctctgaac gttttattgc ggcatcaagc 2062501 ccttcctgcg ccctggcatc agtacgggca acaacaataa gggagggtgc cgcttgttta 2062561 atggctttta ttttttgcgc catttccttt atcggaacta gctgtttgcc atttaaatgt 2062621 ccgcattttt ttgggagctg ctggtcttcc atttgaacgg ctgctaccct ggcttcaagc 2062681 atctcccggg ctgttcgggc ggcatttaag acaccgccaa atcccgtatc gatatccaca 2062741 agcaaaggca gatcagctgc acgcacaaga tctttggccc gttcagctat ctctgccgat 2062801 gtgatgatcc ctaaatcagg cagccccctg ctggctgtat aggcagcacc ggacaaataa 2062861 atagcagaaa aaccggcttc tttcgcaagc aaagcggcca tcccgtcatg ggcgccggga 2062921 atttgaagaa tgtccggtgc tgacatcagc ttgcggaaac gcccggcaag ctcctcttgt 2062981 gacgattgct tattgacgat ccacgacatg aaacaaaatc ccccttttac atgcagaaca 2063041 tgtctacgaa ttcatttacg cgcatcgttt gtaatgtctc atagctggta cagcgctcat 2063101 aaatgtgttt gtgctgttta tcaggaaaat gggttttgag attgtcagaa aacttttcca 2063161 gcagtttcgg cactgcttcc tctcttcgaa aacgatggcc gaggggaaac tcacattcca 2063221 ccatttccgt gctcgttcca tctttaaaat gaacctgaac ggcatttgag atggagcgtt 2063281 tatcaggctt caaataatcc tcggtatatg ttttattttc agtcacttcc attttatcac 2063341 gaagtttatc tattctcgga tcattcgctg tttcagcttc ataatgctgt gcggtgatat 2063401 caccaaaaag caaaccgatt gctgtaatgt attggaggca gtgatcacgg tctgccggat 2063461 tgtggagcgg gcctttttta tcaatgattc ggatagctga ttcatgcgtt ctgatgacaa 2063521 ctcggtcaat ctcgtcaatc cggttcttta cctgcgggtg aagaatgacg gcggactccg 2063581 ccgctgtctg ggcgtgaaat tccgcaggat aagacacttt aaataacaca ttttccatga 2063641 cataagcgtc gagcggacgg gcaagcttga tctctttctt attgaataaa acgtcttgga 2063701 acccccaacc cggtgcactc aaggctgtcg gataacccat ttcccctttt aacgacatca 2063761 gcgccaaatg aacacctctg ctcgttgcat ctcctgccgc ccatgattta cgcgagcctg 2063821 tattcggtga atggcggtat gtcctcaatg ctgcattgtc aatccatgca ttcgaaagcg 2063881 catttttgat ttcttctctt ccgccgccca aaagctttgc tgcaacagca gttgtcgcaa 2063941 ctttgacaaa cagcacatgg tcaaggccaa ctcgatttaa gctgttttct aacgccagca 2064001 caccttggat ctcgtgtgct ttgatcatca tctcaagtac gtcgcgtacc gttaacggct 2064061 cttttccttc agacagcctc actcttgata cataatcagc agcggcaagg attcctccca 2064121 agttatcgga tggatgcccc cactccgccg ccagccacgt atcgttgtaa tcgagccagc 2064181 gaatcatgca gccaatatta aacgctgccc tcacaggatc gagaacatat gacgttcccg 2064241 gcactttgct tccattcggc acagtcgttc ctggaacaat cgggccaagc agctttgtgc 2064301 attccggata ccgtagcgcc aagattccgc agcccagggt atccagcaat acatgccccg 2064361 ctgttgtata cgcttcggca ctagtaatct ctttctcaag cacatagtct gtgatttctt 2064421 cgataacacg atccgttttc ggcattctac cagctccttt catgattttg tttgatatcg 2064481 cgggcccatg taactgacac ggggacggaa gagccgatta ttggcatgct gttcgatcac 2064541 atgggcgcat aaaccggacg ttctcgcgct gaaaaagatc ggcgtatata aaggaatcgg 2064601 tatgccgagc atccaataca ctggggcagc atagtaatcc aaattcgggt aaagcccttt 2064661 ttccttctcc atcagccgct cacccgcttc gcacatctca tataaacgat ggtcaccggc 2064721 tttatcgcat aattgctgca gcgcctcttt catcatgagt gctctcgggt ccattttttt 2064781 catatacacc cggtggccga agcccatgat tttttctttt cttttcagtt ttgtttgcaa 2064841 aagctgctca aaatcagatg tcgtttttgc ctccaaaagc aaatacatca cagcttcgtt 2064901 tgctcctccg tgaagattcc ctttcaggga agcgacagcc ccagtcaaag ccccataaag 2064961 atctgaatgt gtagatgcaa tgaccctggc cgcaaaggtt gaattcggca tctcatgctc 2065021 actgtacagg acgagcgacc ggtcaaaaat ctgttcttcc aatgaagacg gcaatttccc 2065081 tgtcatcatg tagagaaaat tcgcactgta ggatagggtt tgaagcggaa gaatcggttc 2065141 tttcttatta atgatcctgt agctggcagc agtgagggca ggcattttcc caagaagctg 2065201 ataggcgcgt tctttgtttg cggaaggaga ccgatcatca atttgccgat catagccagc 2065261 aagtgccgac aggccggtac gcagaccatc cattggatga gtgtcctcag ggagcagctc 2065321 aagcagacgg agatgatcag caggcaggct tgaggcactg tttattttac gttccagcgt 2065381 ttccatttca ctttcttctg gcagcctgcc ctccagcaat aaatggacaa gctccagata 2065441 gctttttgtt tcagaaagtt ctattaaatc atagcctctt atcaaaatct ggctggactg 2065501 cgtgtcaaga taagaaatat gagtttctgc cgcaatcaca ccgtccaacc ctggagaata 2065561 atgctgtttc tcctccatat cctcaacctc cgtttttgcg ttttttgtct atcaggttcc 2065621 gccaagcaaa tacttggaaa taatcagtct ttgaatctcg ttcgtccctt cataaatttg 2065681 cgtcaccttt gcatcgcgaa gcaggcgctc aactggataa tccttcatat agccatatcc 2065741 cccataaatt tgaacggcgt ctaacgccgc ctttacggct gcatcggaag caaattgttt 2065801 agccatagac gcttcttttc cacagtttag gccgcggtta tgaaggtctg cagcgtggta 2065861 gacaagatgt cttgccgcct cagctctagt cgccatatca gccagcttaa atgatatgcc 2065921 ttgattggct gcaatcggcc ttccaaattg cactcgctgc ttcgcataat caacggcatg 2065981 ctcaagagcc gcctctgcaa ttccgagggc ctgtgccgca atgccgatcc ggccgacatt 2066041 taaattcgcc atggcaatgt gaaagccatc cccctctttg ccaagcaaat tggcttcagg 2066101 cacttctgca ttatcaaaaa tcagttccgt agtattggag ccataaagcc ccagctttct 2066161 ttcttttttt ccaacggtaa aaccgggtgt gtttttttca acaataaaag ccgaaatccc 2066221 gtgcctgcct tgatctggag ctgttaaagc aaatgtgata tagatatcag ctgctccgcc 2066281 attcgttatg aatattttcg atccgtttaa taggtatttg ccgttctttt tgattgctgt 2066341 tgtgcggagg ctcccggcat ccgaccccga gtgaggctcc gttagtgcaa atgcgcccaa 2066401 atggtctcct gacgcgagat ttggtatata tttcatcttc tgttcttcgt tgccgaaata 2066461 cagaatcgga ttcgtgccga ctgaggtatg aacggagaga atcacgccga cagccgcgct 2066521 gattctagaa atctcatgaa ttgccaaaat ataagaaaca acgtccgctc cagcaccgcc 2066581 gtattgttcc ggcaccggta ttcccatcag tccgtgttta cccatttttt tgatcagctg 2066641 aaagggaaat tcgtccgttt tctccatgat ttccgcagcg ggagcaattt cttttcgtgc 2066701 aaaatcacgc accatttttc gcatcatgac ttgctcttgg gttacatgca actcggccac 2066761 ccccggatgg aatagacttc aggaagtctt ctcctcatag tcataaaaac cgcgtccgct 2066821 ctttttgcca agccagcctg ctttgacata cttgcggagc agcgggcaag gacggtattt 2066881 ggaatcgcca aggcctgagt gaaggacttc cataattgat aaacacgtat ccagtccgat 2066941 aaaatccgct aatgcaagcg gacccatcgg atgattcatg cccagcttca tcacttcatc 2067001 tattgcctcc ggcttcgcca ctccctcata cacgcaatag atggcttcat taatcattgg 2067061 aagaagcaca cggttggaaa caaacccagg aaaatcattg acttctaccg ctgttttccc 2067121 catcttttcc gctaatgcca taacatctaa ggccgtttct tctgatgtag ccaagcctcg 2067181 aatcacttct accagcttca ttacagggac gggattcata aaatgcatgc caataacccg 2067241 ttgaggccgg tttgttacag cagcgatttc tgtaataggc aaggaagatg tattgctggc 2067301 caaaatcgta tgaggcgggc aaatgcgatc aagtgtttta aacatctcag tttttgccgc 2067361 catgttttct gcgatagcct caatcacaat gtccgcatgc tctgcctcct caagtgtttg 2067421 agaaatcgaa atgcggttga ttacgctctt cacttccgtc tcggtccttt ttcctttctc 2067481 agcatcacgg gccagctgtt tcttcagccg tttcaatcct gcctccgcgg cctctggatt 2067541 cacatcatac atccgcacat aaaagcccgc gtcggcggct gtttgagcaa ttccgctccc 2067601 catctgacct gcgccagcta ccatgatttg tttgatttcc attcaaatcc cctttttcat 2067661 catgttttaa tgaacctgca ctaagacggc gtctccctgt gctgccccgc tgcaaatagc 2067721 ggcaacgccc agaccccctc cccgtcgctt taattcataa acaagcgtca tgagaattct 2067781 cgcaccgctc gcgccgatcg ggtggccgag cgcgatcgca ccgccattca catttacttt 2067841 ttcaagatcg aaacctacga ttttttcaca tgtcaaaaca actgaagcaa aagcttcatt 2067901 tacttcaaac aagtcaatat cttggacagt taaaccattc tttttcagga gcttgttaat 2067961 agcaaaccct ggcgctgccg ccagctcgtg cgctggcatt cccgtagttg aaaaaccaag 2068021 aattgtagcc agaggccgtt tgccaagctc agcagctttt tcctcagaca tcagcacgaa 2068081 cgcgccggct ccgtcattga ctccaggagc attgccggct gtgatagaac cgtcacttgc 2068141 ataaatcgga gcaagttttg cgagctgatc cagacttgtg tcacggcgaa tcgcttcatc 2068201 tttatcaaca acgtttggtt ttccttttcg accgatccag ttgacgggaa caatttcatc 2068261 ctgaaacttc ccttcatcgg cggccttagc tgcccttgca tgacttctca acgcccattc 2068321 gtcctgctct cttcgtgaga ttgcatattc cttggcagct gtatttccgt gaacagccat 2068381 gtgcacctcg tcaaatgcgc acgttaatcc gtcatacacc attaagtccc taagctcgcc 2068441 gtcccccatc cgtgctcccc agcgcccggc gggaacggca tacggaatat tgctcatgct 2068501 ttccatcccc cccgcaacaa gtatgtccgc atcctgcgcc cgaatcattt gatcacataa 2068561 agtgacagcg cgaaggccgg aagcacagac tttattcagt gtttctgacg gcacactcca 2068621 aggcattccc gccagacggg cagcttgacg ggaaggtatc tgccctgagc cggcctggac 2068681 aaccatgccc atgacgtttc cttctacatc atctccagag actccagcct gttgcagcgc 2068741 ctccttcatc acaatgcccc caagctcagc agctttcacc tctttcaaaa ctccgccgaa 2068801 tttgccaaat ggagttcttg cagcacttac aatgactgtt ttcctcatgg tttcacctca 2068861 ttcagaagat agacagcgct tacaatttct agttgtcttc tatgaatgta tgctttgaaa 2068921 cgggcatgaa tgaatgaaaa aagaaggctg cgtcaaacag cctccttcta acaactattc 2068981 atttttcagc aatgccgaag ccttttctgg aaagtcggta aacatgccgt ctgctcccgc 2069041 ttcaatgaga cgcttcatat cttccggacg attgactgta tacggcctta ccttaatcaa 2069101 accgttcctc attttcttca gtacttcatc tgtgacccct gggctgttta tcttcgggtg 2069161 atagccggaa gccggaatag acgcgatata tcgatctgcc tgataaagca catctgaagt 2069221 taatactgcc cgttcgatat gcggtgcaag ccgggcgcac agcgccaagc tgtcatgatt 2069281 aaacgtggat aggatgactc tgtcctctac attaaatcgc ttcactgcct ccagcacttt 2069341 ttcttccatt ccctcatagc ggatcacgct gttttttaat tcaatgttga tgagaaaatc 2069401 cttttttacc gcccacgaga gcacatcttc tagcagcggc acttttatat cgctgtacgc 2069461 ttgatcgtga ccagcggccg cattcgcagt ctttacctca tcataggctg tatccttcac 2069521 gaatccttta agtgatgtcg tgcgattaag tctttcatca tgaattacaa caatgcgtcc 2069581 gtctttcgtc agctgtacat caagctctat cccatccgct ccggcttcaa ttcctttttc 2069641 aaatgcaagc attgtatttt cgggaaattg acctgatgcc ccccggtggg caaaaatctt 2069701 tgtcatcgtt tcacctcaaa ccctaaagtt ttctccatta tacttatttt gtcggctcca 2069761 ctctaggatt aaggctgtat caatctactg atcataataa gaatcaatgc cattgacaat 2069821 cgcatctgcg gccttttgct ggtattcttc acttcccagc ttgtccgcgt cagagctgtt 2069881 cgtgataaac ccaagctccg ccaacacact tggcatttgt gaatatgtaa tgacgtaaaa 2069941 gtctgattct ttcacgcccc tgtctctcgt ttgtaaggaa gaaacgagct gtgactgaat 2070001 atcggatgcc agacgccggc tgttctcccc ttcataatca gattgaaaat acgtttctgt 2070061 tcctgaagct gaagcaaccc ctgaattcac atgaatgctg acaaaaaggt cagcctgatt 2070121 ggcacttgcc ttagccactc tttcctccaa ggtcagaaaa tgatcgtcag accgggatgc 2070181 aacaggattg gctccctcct cttttagttt gtctgtcaca tgctctgaga cagccaaatt 2070241 aatatccttt tcaaagagcc cgtttccgac cgctccactg tcttcaccgc cgtgtccggc 2070301 atcaatatac actgttttcc cttctatcgg ctctgctgcc tgtgcacaag gcgcgagcgt 2070361 caaagccaat ccgcacagcg ccaagctcct ccataacatt ctcaacttac tccctccggt 2070421 cacgagttct ttcgcagctg aatatcttcc agctgtaaag ttccattatc cttctttgta 2070481 tatttcacca ggacatgtgt ctgatctggc agtgattcac attcatcacg tttatccttc 2070541 ggaacttgta tcatggtttc ttctccatta agagaaaccg caatcgtatg aggatcagcc 2070601 gagccaatgt attttccctc ttcggtaaac ctcggcactg agtcatccgc acttgcaaca 2070661 ctgcaccccg aaagaaagag cgcagtaaac agcaaaagaa ccgtttgttt cacatgacca 2070721 cctcttcctg atgtttggct tttatctttg accagaatgg agaatttgta aagacaacgc 2070781 gaatgcaggc gagcaagttc catgattttc aaaagggcta tacgacccga tcatttcctg 2070841 ttgttagaaa gataacgagc agatttgtct atgaggatgg ctctaattga ggcgccaatt 2070901 agaaaaaatt agcggaaaga agcaactttt tattcatttt aaaaaatttg agaatagggt 2070961 gagcaaatcg tttgacgggt gggtcagcca agcgtaacct tttaaaggat atttacttta 2071021 ttgaaagaag ttaaagccat gaaaaaattc gttctgctgc tggcggcagc tgtcatcaca 2071081 tgctccatcg gccaccaaat cagtggcggc tacaaaggcc ccgaaaaaga gcggccaaaa 2071141 catcactctg cactcaagat attcagtcgg taaagcagat caattgcatt aatttttaca 2071201 tataggctag aatatgtgcg aatccaaacg aaagaagatg atcaaatgaa tcctaagtat 2071261 aagccacttt ttgaaccatt tacgtttaaa agcggcgtta caatcaacaa ccggatcgca 2071321 gtagcaccga tgactcatta cgcttctaat gaagacggta caatatctga agcggagctc 2071381 gactacatca tcccccgttc aaaagagatg ggaatggtga ttacagcctg cgcaaatgtt 2071441 acaccggacg gaaaagcatt ccccgggcag ccggccatcc atgacgattc caacattcca 2071501 ggtttaaaaa agttagcaca agccattcag gcacaaggcg ctaaagctgt tgtacaaatt 2071561 catcacggcg gtattgagtg cccgtctgag ctcgttcctc aacaggatgt tgtggggcca 2071621 agtgacgtgt ttgataacgg caaacaaatt gctcgcgcat taacagaaga agaagtggaa 2071681 aacattgtga aggcgtttgg agaagcgaca agacgcgcca ttgaagccgg ctttgacggt 2071741 gtcgaaattc acggtgcaaa cggctactta attcagcagt tttattctcc gaaaaccaac 2071801 cagcgcacgg atcgctgggg aggaagcgat gaaaaacgat tagccttccc gctcgctatt 2071861 gtcgatgaag tgaaaaaagc cgcttcagaa catgcgaagg gtgcattctt agtcggctac 2071921 cgcctgtctc cggaagaacc tgagacaccg ggattgacaa tgactgaaac ttatacgctt 2071981 gttgatgctt taggggataa agaattggat tatcttcata tctcactgat ggacgtgaac 2072041 tcaaaagcgc gccgcggtgc agatccgact cgcacacgca tggacttatt gaatgaacgt 2072101 gtcggaaaca aagtgccgct gatcgccgtc ggttccatcc attccgctga tgacgcgctt 2072161 gccgtcatcg aaaacggtat tccactggtc gctatgggac gcgaaattct agttgaccct 2072221 aactggacgg taaaagtaaa agaaggccgt gaaaagcaaa tcgaaacagt gatcaaaggc 2072281 acagataaag aaaaatatca tttgcctgaa ccgctatggc aagcaattgt gaacacacaa 2072341 ggctgggtgc cttataaaga ttaatgtgca aagactgccg aaacgattcg gcagtctttt 2072401 ttccctttat ataaatagtt tgtgtacaca tctaaacagc aaaagaaaga gctccccacc 2072461 aacttcgaaa agaaaatcca ggaaaaaccc ctcacgcttt cttgcttttt tctttttcat 2072521 tcgtacgtct cctttttaca tgaatacgcc ttacttacga ttttgcagga gaaaggtttc 2072581 attttataac ggacacatct agggtcgatc atgcttcgtg atcctataag atgtatgaat 2072641 ggaccaagag tgcaggtaat accgccattt gctttcctta cttttcaaac ctatccttta 2072701 ctatatgcgg atacttaata ttcttctccc atactacaaa tgtccccaaa acaaaacgcc 2072761 tcctatttat cagcgcaaac taataaataa aagacgtttg atttaatgac cacttaataa 2072821 gctcatgttt aagaagcctt atgctctaac ctcagcttat ccgcaaccat tgcaatgaat 2072881 tcactgttgg taggtttagc ttttgtcatg ctgacagtat aaccaaacaa cgaggaaatg 2072941 gaatcaatgt ttcctctgct ccatgccact tcaattgcat ggcggatcgc tctttctaca 2073001 cggcttgcgg ttgtgttaaa ttttttggcg atgtccggat agaggacttt tgtaatgctg 2073061 ccgagcaatt cgatgtcatt gtataccatt gagattgctt cgcgcagata gagatagcct 2073121 ttaatatggg ctgggacgcc gatttcatgg ataatgcttg tgatgctcgc gtcgagattt 2073181 ttcttctttg gttcaggctg gctgctgcgt ataatactgc tttgcgatga tggcgcacga 2073241 tgcgtcacac tgctggcatt tccgctgacc tggcggatat ggccgacaag gttttccata 2073301 tcaaacggtt tgagaataaa gtaggacgcg cctaaatcga cggccttttt cgtgacatct 2073361 tcctgcccaa aggctgtcag cataatgaca ttcggctgtt ttttcagatc tgattccctc 2073421 agcctctcta aaaccgcaag tccgtctaga tgcggcataa taatatctaa tacgagcaca 2073481 tcgggatctt tttctttaaa cagcgacagg cattcctgtc cgttataagc aacgccgatc 2073541 acttccatgt cttcctgtcc ttctatatat tcacttaaca ggcttaccag ctctcgatta 2073601 tcatcagcaa cacaaacttt aattttctcc acgtttcttc ctccccaaat gtagttaaca 2073661 ggattcaccc ttgctacatg tttacattcg acaaaaccgc tatataccct ctaaaaaaat 2073721 cataatcacc aatattagtg gcatatcttt gttattctat gtttttctct gtttttcgac 2073781 taaaaatgaa atttgacaaa caaggaaacg tgaatttgtc gaaaaatctt cttttgtata 2073841 ttttaccgta tgtattctga gaagtgaaga gggatcagga tatactgatg aacgaatgga 2073901 tgtgcacgaa aaaaataagc tgcgcttctc gcgcagctta cccagttgtt ttgacttgat 2073961 ccgcttgttt taaaagttct ttcgcatggc gtttcgttaa gtcggttact tcgacacctg 2074021 caatcatgcg cccgatttcc gctacctttt cctgcttaga gagcggcttg acacgtgtcg 2074081 tcgttctgcc gtcttttaac tccttcgcaa tataaagatg cgtatcggcc atggcagcca 2074141 cctgaggcag gtgtgtaatg cacagcactt gtgatcctat tgacacctta tggatcttct 2074201 cagcaattgc ctgtgcgacc ctgccgctta caccggtatc aacctcgtca aaaatgatcg 2074261 atgtcacatc ctgttgtgag gaaaaaatgc tttttatggc aagcatcacc cgtgacagct 2074321 ctccacctga agcgactttc gaaagggatt tcagcggctc gcctgtattg gttgaaatta 2074381 aaaacttcac caggtcaatc ccttgttcag tcagctgaac gggctggccg tttacaagcg 2074441 gcgcctcttc attgcgtgac gctgttctga ccttaaattc cgtatcaaaa gttgattttt 2074501 ccatgtacag gctttttaat tcccgatgaa tctcatcagc cagctttttc gcccatgttt 2074561 ttcggatttg tgacacattt gccgcttcca ctgcgacatc tttgccgacg gagtcaagct 2074621 cctttttcaa gctttgaagg tggctgtccc tgttttcaat ttggtcaatc tcttcttcaa 2074681 ttttagaagc atattccaaa atgtcttcaa cagtggcacc gtattttcgt ttcagctgtt 2074741 tgatttcatt aagtcgcgtc tcaatatagt tcaggcgttc cggatcaaat tcaagctcat 2074801 ccagcatatt tctcatctga aatgtggcat cctcaagcaa atagtaggag ttcgaaacac 2074861 tttcagacat ttttttcagc ggttcgttta tatcagatat atcttcaagc tgcgctgatg 2074921 ccattccaac ccagtccaat ccgccctgct cactgcgaag cgcgttatat gcattttgca 2074981 gcgactcata tatcttctca aagtttgaaa tttgctggcg ctcttcttgg agctgttcat 2075041 cttcgttaag ctcaagcttt gccgattcga tttcttcgag ctgaaattga ataagatcaa 2075101 gacgatgggc catttcctgt tcgctttcag aaagctgctt aagctttttg agcagcttca 2075161 cataccgctg gtacccttcc tgatacgttt tgagcgcgct ttccacttcg gccccggcaa 2075221 acttgtccaa aagctggaga tgattttcgt cttccattaa cagctggtta tcgtgctgcc 2075281 cgtgaatatc taataaaagc ctgccgatct ctcttagtga agcaatcgtg acaagcttgc 2075341 cattgacacg gcaaacgctt ttcccgctcg tgctgatatc ccttctcatg acgatcattt 2075401 cgtctgaaac gtcgattccc tgctcagcgc atacgcctaa aacaggatgg ccgctctcca 2075461 acagaaacag cccttcaagt tcggcttttg cttccccata tctaacaaat tcagatgatc 2075521 cgcggcctcc gactaaaaga gaaatggcat ctatgatgat ggatttgccg gctccggttt 2075581 ctcctgttaa aaccgtaagc ccgcgttcaa aagaaaccgt cagttcctca ataatggcaa 2075641 agtttttaat cgatagttca gctaacaaac agcattacac ctcttatctt tgttagattt 2075701 tctgttacag cagttcaagg agcctgtttt ttacgccttc tgtatcttca ggagtccggc 2075761 aaataattaa aatcgtatca tctccgcaaa tggtccccat catttcatcc cagtccaaat 2075821 tgtccatcag cgccccgatt gcctgggcat tgcccggcat cgttttcagc acaatcatat 2075881 ggcttgctga gtctattttc acaaatgcgt ccatcaatgc ccgctttagc tttgacagcg 2075941 gattgaaacg ctggtccgcc ggaagactgt atttgtaaga accattattt gtaggcactt 2076001 ttacaaggtg aagttcttta atatcccgtg ataccgtggc ctgcgttact ttgtatccat 2076061 cctgctttag catgtcgacc aattcatcct gcgtttcgat ttcattgctt gtaatgatct 2076121 ctctgatttt aatatgcctc tggcctttgt tcatgtaagc acctctattt ccaagcttat 2076181 ctgttctttt atgttatatg attctctgca cattgtacat gaatgcagaa aaaaggaata 2076241 atagcgccct attattccgg tacatctgct tttttttctt ttaacgtctt atgtgcttct 2076301 tctacaacgc gcatgatctc ttcttccggc agttcctggc cttcctgtcc ctctcccggc 2076361 caatgcaaat gaaggagaaa ctcaatattt ccgtctcctc ccgtgattgg agaaaatgac 2076421 aagcctttac agatatagcc ttcagcggca gaaaaactga tcattcgctt gagcacatca 2076481 gcatgcactt taggatctct aacaatccct tttttgccga cggattcccg tcccgcttca 2076541 aactgaggct taactaaagc catgcagtcg ctgcccggta cgagcaaagt ccttaggaca 2076601 ggcaggatga gccgcagtga aataaaggac acatcaattg tggcaaactc cggcatgccc 2076661 tttgtaaagt ctgccggtgt tgcataacga aagttcgtcc gttccatcac gacgacccgt 2076721 tcatcctgtc taagcttcca tgcaagctga ttatagccta catccacagc gtatgactgt 2076781 ttagctccat tttgcaaagc gcagtccgta aaaccgccgg tggaggagcc aatatcaatc 2076841 ataattttat ctttgacaga gacgggaaat tccttcaacg ctttttcgag ctttaagccg 2076901 cccctgctca catacctcag cgggtttcct ttgacagtta acggaaggtc gcggtcaatt 2076961 ttttctccag gcttgtccaa gcggttttcg tttgaataga cgatccccgc cataatggct 2077021 cttttggctt tttcacgcgt ttccgccagc cctctttcca ctaataatac atctaatcgt 2077081 tctttctttg acgtcatgat ccaattcctt tgtgtgtctt tggtggcatc agtaatctaa 2077141 tacgatttgc cacctgctgt tttgtcagtc caatttcctc aagaagcgct gttacacttc 2077201 cgtgttcaat aaaccgatca ggtataccca ttctgtcaat cggagtatga tattcacctt 2077261 gatcatgagc gaattctaaa atcgagcttc cgaaaccgcc ttctaagacc gcttcttcaa 2077321 ttgttaaaat tggcaagcct tcttttagga tactcttcat catcttttca tcaatcggct 2077381 taataaaacg cgcattcaca acgcgcacgg aaaggccttc tttctgcagc tcttcggctg 2077441 cttcaatcgc catttcgatt gttgtgccga atgttaagat gacagcatcg ttccctggac 2077501 gcagcacctc ccacgtaccg atcggaatcg ttttcaactg ttcatccatt tttacgccga 2077561 gtccgtttcc gcgcggaaaa cgcattgcta tcgggccttc gtcatagcta agtgctgtat 2077621 gaaccatgtg ctggccttca ttttcgtctt tcggcatcat taagaccatg tttggaatgt 2077681 ggcgcataaa cgcaatatca aacacgcctt gatgtgtctc tccatcagcg ccaacgagtc 2077741 cagcacggtc aattccaata aacacattag cgttttggcg gcagatgtca tgaacaactt 2077801 ggtcatatgc cctttgcagg aaggttgagt aaatcgccaa aaacggcttc ataccctgca 2077861 ttgccatagc tgcagccatt gttgcggcat gctgttctgc gattcctacg tcgaacatcc 2077921 ggtcagggaa ttcctttgcg aagccttcaa gctttgaacc gacaggcata gccggcgtaa 2077981 tggctacaat gcgtccgtcc tcgcgcgcca ttcgctgcac agttccgctg acaagaccgc 2078041 tccacgaagg agctgcggct ttcggcttta caaagtcacc ggtattaatt ttatatggtc 2078101 cggtaccatg ccatgtccca atcgtatcgg tctcagccgg tttgtacccc ttcccttttt 2078161 tcgtaatgac gtgcagaaga acagggcctt tcgttttttt ggcgtattga agattctcaa 2078221 tcagctcatg ataagaatgt ccgtccactg ggcccaaata cgtaaaaccg agctcctcga 2078281 aaaacattcc ggagacgagc atgtatttca ggctgtcttt gacccgttcc gccgtggcgg 2078341 caagcttgcc cccaactgcc ggaatctttt taaataagta ttcaagctca tctttgaccc 2078401 actggtattt ccccgcagtg cggagccgtc cgagcataga gtgaatggca ccgacgtttg 2078461 gcgcaatact catttcatta tcattaagga tgacaatcat gtcttttttc tcgtcgccga 2078521 tgtggttaag ggcttcgagc gccataccgc cggtcagcgc gccgtcacca atgatcggaa 2078581 taatatattc atccgttcct ttaatatcac gggcagctgc cattcccatc gcgcctgaca 2078641 gagaagtcga gctgtgcccg gtttcccaaa catcgtgctc gctttcactc cgctttggaa 2078701 atccgcaaag ccctttgtac tggcgaagcg tcgcaaattc ttttccgcgt cctgtcagca 2078761 gcttatggac atacgactga tggcctacat cccataaaaa tttgtctttc gggctgttaa 2078821 attccttatg cagggcaaca gtaagctcta cgacacctaa gtttgggccg atgtggccgc 2078881 cggaagcgga taaacttgta attaaaaact gacggatttc atcacttaat ttctctaatt 2078941 catcaatgga catgtttttt aaaaacgacg ggtcctgtat tgataaaaga tccaaagcgg 2079001 atcaactcac tttcagcatg aatttctgca atgatacatg tcttttgcat gccgagctga 2079061 caataatctc agacataaaa aaagacaaac gcgcttttcc ttttcatttt tcatataaac 2079121 tgcttacatt ttaccatacc tcgtgcagcc gcttcaaatt aggatcgttt tagtgatctc 2079181 ttgccgcaat taaatcacaa agctcatata aaaggtcttt ttgaagagag agtccgccga 2079241 tcaatcgctt cgcctctttt atatgaacat ccaatttatg tttggcccct tccaatgaaa 2079301 gaagcgacgg gtatgtcgat ttgtcatttg tggtatccga gccgacacgt ttgccgattt 2079361 tctcttcact gccttctaaa tctaaaatat cgtctctgat ttgaaatccg attccaatgt 2079421 ggctgctgaa ggtacgcagt gtttcaatgt cttcctcagg cgcatcagcc aaaatagcac 2079481 cggcgattac acaaaagcca aggagcttgg cagttttccg ttcatgaatg gattcgagct 2079541 cttcaagcgt gacttgtcgg ttttccgctt ccatatcagc tacttgccca ccgaccatgc 2079601 cttcggtgcc tgccgctgaa atcagttcat tcacaagccg caggcgcttt tctgctgaca 2079661 cctcgtctga cacgtgggag gtaatcagct taaagctttc tgtgagcagc ccgtcacccg 2079721 ctaatactgc cgtcgcttca ccaaacactt tatggtttgt cggcttcccg cggcgcaaat 2079781 cgtcatcatc catgcatgga agatcatcat gaattaacga atacgtgtga atcatttcga 2079841 cagcacagcc caccggaatg ccgtcttttt cgctttttcc atatgcattt aaaacagcca 2079901 gtacaatcag aggccgcaac cgctttccgc cggcctgtag agaatatagc atagatttct 2079961 ttaatgagtc cggcatatca agcttttctg tatagacaga aagctgattt tcaattgttt 2080021 ttttccggtc cgccagaaag ctcgttaatt tatttgtcac cttcgtcttc ctcctgaaca 2080081 ctgaaaggtg ccagttcgcc gtcttctttt aaaatgaagt ccatttgctt ttcgactttt 2080141 tgcagctttt catggcacat ttttgacaga gccatgcctt cttggaaata gttaatggct 2080201 tgctctagag gcacatctcc ctcttcaagc tttgatacaa tgctctcaag ccctttcatc 2080261 gcttcttcaa atgtcatgtt ttcatttttt ttcacgtctg tcatttttct tcccctctct 2080321 tttctaatac ttcacaggtc agcacgccat ccttcagctt gatttcaagc cggtcctgct 2080381 cttctatttg actgacactt ttaatgagtt tatcttcttt ataagccaag ctgtatcctc 2080441 tttccatcac ttgaagagga cttagtgcat tcagcttgcc aagaacggtt tgaaattggg 2080501 aatgcagctg cttcatttgg atattcatat tttttctcag ctgatttgtt tgttcctggt 2080561 atcgtgttct cgcttgtttc agctgttcat gaggatgcaa tgcctctaat ctgtacgttt 2080621 cacgctccag ctgtctgctt ttccgatcta aaagagcggt cagctgtgct tgaaactgct 2080681 ggtacgcgag gtcaaactgc tgctcttttt gcgcatacaa acgctttgga aaacgaaagg 2080741 cataggacga ttgcagcgtt tgtatccgtt cttttttctg gccgagatgc tgctgcattg 2080801 ctcttgtcat tctgacttcc gctgtttttg tccgttcgat taaatcagtg gtatgaggca 2080861 cagcaatctc agctgctcct gtcggcgtcg cagctctgat atcggcgaca aaatcactaa 2080921 tcgtaaaatc cgtctcatgt ccgactgccg atataatcgg aatattggaa gcaaagatgg 2080981 cgcgtgctac aatttcttca ttgaatgccc acagttcttc tatcgaaccg ccgcctctcc 2081041 cgacaattaa tacgtcgcaa atctcttttt catttgcctc ttcaatgcgc gtaacgatgg 2081101 atctgctcgc attttcacct tgtacgagcg ctggaagaac aatgactttt acaaggggat 2081161 atcttctttt tagagttgta ataacgtctc tgacagcggc acccgttgga gatgtcacaa 2081221 ccccgattgt ggctggaaat gcggggattt gttttttgta gcggtcgtca aataaacctt 2081281 ctccggcaag cttctttttt aattcttcgt acgctaaata aagcgctcca accccgtcag 2081341 gctgcatttc tttggcatat aattgatagt ttccgctcgg ttcatatacg gaaattccgc 2081401 ctctgaccag cactttcatt ccgttttcag gtttaaaagg cagacgctcg ctttgtctcg 2081461 cgaacatcac cgactgcatt cttgcgtttt cgtcttttaa agtgaaataa atatgccctc 2081521 gtgtgtgtat ctttacattc gacaattcgc ctttaatcca aatattttca aggtgaggat 2081581 ctacatcgaa ttttcgtttt atatactttg tcagcgctga gacggtcaca tacgctgctt 2081641 cacccatgtc taaaaactcc tctcctaagc attcctgcac cataactaaa gaaaacccgc 2081701 cctggcttta ggagcctgaa gaagcgggta tcgtgctcat attcaaggcg ggtaaacatt 2081761 tcgcctgtga atatctccaa ttatctatga taacgtacgt ttcgcagatt taacagtatt 2081821 atgcgcaagc atcgtgatgg tcatcggacc tactccgccc ggaaccggcg ttatgaagga 2081881 cgctttttcc tttgcccctt caaattcaac gtctccgcaa agctttccgt tttccagacg 2081941 gttaacgccg acgtcaatga caacagcgcc ctctttgatc tggtctgcac tgatgaagtt 2082001 ggctctgccg actgccacca ccaggatgtc cgcttttttc gtatgttcag taatattttc 2082061 tgttcttgaa tgacagtaag taaccgtcgc gttttcattt aataaaagct ggccgacagg 2082121 tttgccgaca atgttgcttc ggccgactac aacaacctct ttaccggaaa ggtcaatatt 2082181 ggttttcttc aaaagctcaa caattccatg aggcgtgcaa ggaagaaacg tatcttcgcc 2082241 aagcagcatt ttccctacgt ttaacggatg aaaaccgtct acatctttat caggggagat 2082301 acgttcgatc accgcttttt cagaaatatg gtctgggagc ggaagctgaa cgagaatgcc 2082361 atgaaactca gggtcttggt tatattgatc aataatggaa agcagttcag cttctgtgag 2082421 gctgctgtca aattgatcga gcttgaaatt cattcccatt gtttctgccg cttttttctt 2082481 tcctcgcacg taagagtgag aagcaggatc atctccaatc aaaataaccg ccagtccggg 2082541 agtgacgcct tgctttttaa gctcttctac ctcttttgcc aattgttcgc gtttttctct 2082601 agccgtttct tttccgtcga tgattgttgc agtcattttc tttcctccta tgattgttca 2082661 atatcagatt taatgttaga aagaaccccg tttacaaact ttgtcgcttt gtcatcacca 2082721 aaccgttttg ccagctcaat cgcttcgttc atggagacat tcaccggaat gtcttcggca 2082781 tatgccattt catatgctgc caggcgcaaa atcgcacggt caacattggc aatccgatcg 2082841 agcttccaat tcaccagatg cttggagatc atttcatcca gctggtcttg gtgttccaat 2082901 accccgtgta caagctgttc aaagaaagga tctgtttttt cttcatccag tgcgtgttct 2082961 atggcttcat tcactgcaat atcgctgaca tcaatttgaa atagtgcctg caaagctttt 2083021 tctcttgctg ttcttctttt cattttcttt ctcctttgat cctctttatc cgcttgtcgt 2083081 taagccacaa agagatcata acatattttt ttcgtatccg catattgaaa tcaaggtttt 2083141 tttaccctat taccgaatat tttcacacac cttaatatga ttattcggat ttcacgttca 2083201 tgaagaaact cggctatgta agccggcttt cttcatgctt tgaaataaag ggtaacgtgt 2083261 aaaaaaacca aagggccgcc ctccccttgg tttcgtgtta agccatttac atttcttcgt 2083321 cgatttggac ttcttgggct tttgtgtcaa attgaatgcc gacgatgtga atattgatct 2083381 cgttaatcga aagagacgtc atatttaata aggtttgacg aatgttttcc tgaacggatg 2083441 ctgcaacttt cggaatcgaa acgccaaatg taacgacaca gtatacatcg atcgtaattc 2083501 cgtcatccgc caggtcgact ttgacacctt tgccatgatt cactttgcca aagcgctcaa 2083561 cgacgcctgt cgcaaagttt ccgcgcattt cggcaactcc atcaacttct gatgctgcaa 2083621 tgccggcaat gacctcaatg acctccggtg caatctcaac cttacccaaa tgcgtatctt 2083681 cgtgatccat tttaagcaag ctgttgtctt tcattcaatt cacctccgta aaaattatga 2083741 gcccattaca tcatatgttt ctaaaaattt cgtattaaac tctccgctca caaatgtttc 2083801 gtgttcaagc agttttaaat ggaaagggat tgttgtctca atgccttcga tgacgaattc 2083861 gctcaatgcg cgcttcatgc gggcaatcgc ttcatctctc gtttttccgt atgtgattac 2083921 ctttgcaatc atgctgtcat agtacggtgg gatggaatag ccagggtacg cagctgaatc 2083981 gacacggaca ccaagaccgc caggaggcag gtacatttta atttcaccag gtgacggcat 2084041 gaaatttttg cttgggtttt ctgcgttgat tcggcattcg atggcccagc cttcaaattc 2084101 aacatcttct tgcttgaggc tcagttccat tcctgaagcc actttgattt gttccttgat 2084161 caggtcagtt cccgtcacca tttctgtgac tgggtgctcc acctggattc tcgtgttcat 2084221 ttccatgaag taatagcgct gttcattgta gtcatagata aattcaactg ttccagcacc 2084281 tgtatagcca accgctttgg cagcctttac cgctgcatct cccatttgct ccctgatttc 2084341 tgaatcaagg gcaggagatg gtgattcttc caaaagcttt tgcaggcgtc tttggatcga 2084401 gcagtcgcgt tcgcccaaat ggatcgtatt tccgtagtta tcagcaagca cttggatctc 2084461 aacgtggcga aaatcttcta tgtatttttc gatgtataca cctggattcc caaatgcagt 2084521 tgccgcttcc tgctgtgtaa tcttaatgcc attaatcagt tcctcttcag tgcgggcaac 2084581 cctaattcct tttccgcctc cgcctgcggt ggcttttata attacaggat acccaatttc 2084641 attagcaagc gaaaccgctt cttccacatt ttctataatt ccctgtgaac ccggtacgat 2084701 tggcacgccg gcctgtttca tcgtttcccg cgcaacgtct tttgttccca tttttgaaat 2084761 ggcgtcagcg ctcgggccga caaacgtgac attcacttct tcacataatt cagcgaaatc 2084821 agcattttca gctaaaaatc cgtatcccgg atgaatggcg tccgtgccag tcagctttgc 2084881 aacactcaca atatttgtaa cgtttaaata gctgtctttt gatgctttcg gtccgataca 2084941 aaaagcttca tcggccattt gaacatgaag ggcatcttta tcagcttctg aataaacagc 2085001 gacagtctca attccgagct ctctgcaggc tctgatgatt ctgacagcaa tttctcctct 2085061 gttggcgatc aatagctttt taatcatgtt cagtctcctt actccgcttt tacaagaaat 2085121 agaggttgtc cgtattcgac cagctggccg ttttctacta atacttcaac gatttcgcct 2085181 ttcacttctg cttcgatttc gttgaaaagc ttcatcgctt ctacaatgca gacaactgtg 2085241 ttttcattta cttttgaacc ggctgttaca tacgggccag cttccggtga tgaagaagca 2085301 taaaatgttc ctaccattgg tgaagtgatt ttatgcagat tctcatcttg ctttggtgct 2085361 tcttgggcag gtgccgctgc ttgctgcgct tgcggctgaa ctgcctgcgg agcctgtgct 2085421 tgtacaggtg ctgccggtgc ctgctgcatg acttgaaccg tgcctgcttc gtgttttttc 2085481 agttttaagg atacaccttc attttcatat acgaattcgt caattgtaga ctcgtcaatt 2085541 gctttaatca gctcgtggat ttctttgata tttaacattc aatcgcactc ctatgtatga 2085601 aatttctttt tttataggtt actactaaaa gtacatacta tgttcatctt acaggagcgg 2085661 acttttgaat tcaactctaa tatgacagca acgcaaaaag cccgcttgtt tagcgggctt 2085721 ttttccctca ttcttattta gagggttcaa atgtgacagc gacatctttc attgttttga 2085781 tttcttttgc cacaaggtct ataatggctg tcgccttcga tttagagtgt ttgtctgatt 2085841 tgactgtaat attgatttta tctccttcag cattaacaag cgcatcctcg taaccttgtg 2085901 ttttaatcag cgtttccagc tgtttttctg ttccttccac ttcactgaga gccgtcattt 2085961 tatcgtatgc ttcgcttttc tccttggctg ttgcatcatc gcttgacaca atggcattca 2086021 gctcttctct ttctttgctt ctggcatctt ctaaatcaag acggtacgtt gtaaacaaat 2086081 catcatcggc tgtttccgta acaacagttc ctttttcact ggcttcagcg gatgtttcct 2086141 tgtctgctga tgaatctttc gttccctttg ttccatcttc ttttcctttt tcagtttctg 2086201 taccgctttt ttccttcgtg tcttgcttgg caggcgcttt ttcagttgcg acctctccgc 2086261 tgtcagacgc gcttttttca ctttgcatct gcacggcgtt tttgctttcc ggcgacatga 2086321 tatagtagac gcttaacacc acgacaagac tgagcattgt taatagccaa acggtttgtt 2086381 ttttaagcat ttatgaatcc tcctttattt ttttaggggc aaccgcaacc cggtggcttg 2086441 gaacatccag gacccgtgtc accgcttcga taatggtttg ttttatttga acgttgtcca 2086501 ctccttgagc aacaacgagt acaccgcgta tatcaggttt tttcgtttgg acgacgacag 2086561 gtgtttcttt atcgccgttt ttgatcatga cgatttcttc ctccgatgat tggtctgtaa 2086621 cgcttctttt tccgccttct ttgtcagttt cttcagtggt tgtatttttg tttgatttgt 2086681 ttttttcgta tactttcagc gacgttgcat ctacattcac gacaaccgag acatcgtcca 2086741 caccaatgat tgtttcaaga atttctttca gttgattttc gtattctttt tcatagtcat 2086801 cgatcgagtc tttaggttta tcagattttg aggctttaaa cacttcggct gttttctctt 2086861 tgctgtctgc ggaatgttgt gatgatacgg ccgttatcgt tttggcgttt tcagttttct 2086921 caggtgaaga aaacagctgg ctgacaagca taaaggaaac tccgagaaca aaaacgaata 2086981 gaaagtaatg atatttggtc agcttcggct tttcgccgtc cttcgtttgt cccggaagaa 2087041 actgcttttt caatacattc cataatccgt ttttattcat tgccgacact ctccccgcct 2087101 tccatatgaa ccgtaatttt ctcacttccg atttcccaaa tgtccgcgag ctgcgtttgt 2087161 atctgtttgg cttctttttg ttcggctgct tcttttgtta cgtatgcatg atctgtatca 2087221 atgtggaccg gcgcgaccgt ttggaccgtt ttttcagaag acggggccat atacacgctg 2087281 attgttttaa tatcctcttc tgaatctacc ttttctcctg ccgtgagttt gatgcggcct 2087341 actttatatt catcatgact gaatctctcc tccgctttct tttttagttg gacagccatt 2087401 tcttctagaa tatatgcgcg ctgggaagct tgtatttcta ttttttttga attgatttga 2087461 ttttttatgt cggcagactc tgactgcccg ttttttgtga ggtattcaaa gatgacttcg 2087521 gggtctgtct tgaaaagttt aaaaatcggc gtaagcatga cgacaatcaa gagcaggctg 2087581 actaccattt ttgcgtactt ttgcatgctg gagctcggca gcagcatatc aatcacaatt 2087641 gcaaatagga taaacaacac gatggtggta agccattccg ttaaaaaact catttgcctg 2087701 cctccttcat ttcatcatca tcgtgaggtt tccggctgtg attatgacag taaggcttaa 2087761 aaaaaacatg agagacacaa tggcgagagc tgcaaaaata taaatgacgc ttttgctgat 2087821 gacgtcgagg caggtgatga cgggcccgcc tcctagcggc tgaagaatcg cggctgccag 2087881 cttataaata aaagcgaggg aaagcacttt gattgccgga aatgccgcaa tacagatcaa 2087941 aatagcgaca ccgagaatcc ctaccgtatt tttcagcagt aaagaggcgc tgattactgt 2088001 atctgttgcg tctgtaaaca ttcggccaag cacaggaata aaatttccgg ttataaattt 2088061 agccgtcctg agcgtaatgc cgtctgtcac tgcagctgac gctccctgaa cagagatgac 2088121 gccgagaaag atggtaagaa aaacagccag tgctccgatg gcgatatttc tgagcaggtt 2088181 agccagctgc gttactttgt attgttcagt catcgtgctg acaatgctca gaatcgctga 2088241 taaaaaaatc agcggcatga cgatattctg aatcaagaga ccgctcgtgt tcatcaggaa 2088301 gaggataaca ggatgaaaga aggcagcaga tacagctccg cctgaggaag ccaaaagcgc 2088361 caagaggagc ggaatgagcg ccaggataaa gctggtcatc gtctgaatcg cctcagttgc 2088421 atagttaatt gccacatgaa agctattaag cgcaaggata atcagcacca tgtacacaat 2088481 tgagtaagcg accttactga cggtgctttg ctgaaaagca ttttgcaaaa gctgcagaat 2088541 gacgcaaaaa atcgtgagca aaatcaatgt gcccagcagc tttccgttgg caagcacttc 2088601 atgaaacaaa taagaaaaga gagctttcag ccattcttgc ggtgagaatg atttatcgcc 2088661 attgataaac tccattaagc tgcctttttg gctttccggc agcagtccgc cgtattctgt 2088721 cataatgtca ttccaaaatt ccccgatctt atctgtttca agcgaggctg ctgtcctttc 2088781 cgctaattgc tcggctgttt cagcatggtc ttccgtttgt tctgcattac cagctgcttg 2088841 tacaatttct gcacggcctg ctatgatcag cacggccaaa agcaaaaccc attgaaagcg 2088901 cttcaatcta ccgcctcctt tcggttatga catagaaggt ataagtccga gaatcgtttc 2088961 gataatgacg gttaaaatag gcacagccat tacgagtatt aaaattttcc ccgccaattc 2089021 tattttcgag gcgatggctc cttgaccggc atcttttgtg agctgtgccc cgaattcagc 2089081 aatataggcg attccgataa tctttaaaat ggtttcaaca tagaccatgt tgacatttgc 2089141 attaatcgca attttttcta tcattcgaat aatgtcgtag atttggtcta ccaaataaag 2089201 aaaaatggca catccggcaa aaacgacgat taaaaacgca aaagtcggct tttgttcttt 2089261 tacaattaaa gaaaggaagg tggcgatcag ccctaaacct acaatttgaa caatgtcaat 2089321 ctgcaagccc ccctatcctt ggaataaaaa cacagctttt atctttttaa ataggtcatc 2089381 tacaatcgtg gcgaccataa ataaaatata gataaaacct aacagcgtca cccactgagc 2089441 atattctttc ttgcccatct gatccaatat cgtgtgtaaa aaagcgacca cgattcccac 2089501 tccggcgatt tgaaatatga cattcacgtc tactcccatt ttatttttgc tcccctcacg 2089561 tttacatcaa tagaagaatg agtaacaagc ccgctaaaaa gcccaaactt tttatcatct 2089621 tttcgttttt cgcttgcgcc tgctcagcat ccgcttctga ggcttccaaa tgtgtcagcg 2089681 ccagcttgat gtgcttttgc tgagagattc gatcatgaat cccaagcgtc tcgccaaact 2089741 gcttcagcac ttcgtattcg ctttttttca aagacagggt gtcccatacc ttctttaagc 2089801 tttgctccca cgccgttttc gcggaatcac ttcccttgtc cagctgatca ctgaatgcgg 2089861 aaaaaagagt tgaaacaggc tgtgcgagct gtttggcaat ctgctgtgaa gcagtatgaa 2089921 gcggtgtatg gccgtacatg atttcagcct cgagggattg aagcgccgca cgcagctggc 2089981 ggatttgccg cggccgttct gtataaatct tcgccatctc aaaacctgtc catgttgtcg 2090041 ctaccacaat gaatacagcg cccagcagct tcagcatgtt ttcacgcccg tcgtcctaga 2090101 cagcacattt ccgtctttgt cataaatttg gctcactgtg cccggccctt ttgctcttga 2090161 taattccaaa tagcggtcaa aggctctttc ttcccacaaa cgcttcaatg aaggccgctt 2090221 catcaggtcg gatatactcc agccatgcgc cgatacgatt actgaaacac cggcatgcag 2090281 cgcctccaga agtgcatctg tatcttccat acgcccgatt tcatcgacaa tcatcacctc 2090341 agggctcatg gatcgaatca tcatcatcag cccttcagct tttggacagg cgtctaacac 2090401 gtcaattctc tgaccaaatt gatgctgcgg aataccgcga agacatccgg caatctctga 2090461 ccgttcatcg acgatccctg tctttacggg cagcatgttt tttttgccgg tgcttgagag 2090521 cctcgcaagg tcccggagaa gtgttgtttt gccggtttgg ggcggtccga taatcagcgt 2090581 attcagccag ctgttttgat ataagtatgg aagcagcggc tccgcaatcc ccagcttttg 2090641 ccgggcaatt cgtatattaa aagatgcgat gtcacggagg cctttcacac ctccgttttc 2090701 cgtaatgact ctgcccgcca gtccgactct gtggccgcct ctgatcgtga catacccttt 2090761 cttcagctct tcttcaagtg tatacatact atagttgctg agccggctca ggatcagatg 2090821 ggcatcctcg gccgtgcccg cataggacaa ataaacaggt tgtcctcttc gaatcaattc 2090881 aacagggcgg ttgatccgaa ttctgacttc ttcgatttcc agccattgtt gttccggtat 2090941 ttcagaaagg gcgtttttca tggattcagg gagaacctca gcgatttcat tcaacagagc 2091001 ctcctccttt ctaccgattg gcttctttaa aatgtatgat gtgaggcaga ctttatgaca 2091061 agcctctctt tatttatgaa cacccgccaa aatcaagaca acacccgtaa aaatcagaat 2091121 cagctttgca tacgaaagct gcccggcaat ttggtagatt ccgacagtca ttgtaatgat 2091181 aaaaatcaac ggaccgacaa tagcgagaat gctgttaacc acaaccgcct tccggacatc 2091241 gttggtcaca agcatgacaa ttgctgccgt cagctcaatc atagaggata aaactcgtaa 2091301 tcccgccatt gttaaaacag tagaattgat atttccaagt aaaaatttca tagcactctc 2091361 ccaacctccc atttttttat atgatatgct ctagcttgct gaagtagtct tgtcattttc 2091421 gtataaaaga aagattctgt ttttgggcac aaaaaaagcc tgctcccatt tgggaacaga 2091481 cttctttttt tctttctatg ctcttgaaac gtaagaaccg tctgatgtat tgacaacaag 2091541 tgtgtcgcct tcattcacaa agaacggcac gtttacaaca agcccggttt cagttttcgc 2091601 aggttttgta ccgcctgacg ctgtatcacc tttaatacca ggttcagttt caacaacttt 2091661 cagctcaact gtgtttggaa gttcgatacc aagtgtttca tcctggtaca tcatgatatg 2091721 cacagacatg ttttctagca ggtattttaa ttcttcttcg atttgagttg cgctcagttc 2091781 aagctgctca taagaagaag tatccataaa tacgtgctga tctccgtttg catatagata 2091841 ttgcattgtt ttggtttcga tttgcgcttt cgctactttt tcaccagcgc ggaatgtttt 2091901 ttcctgaatc gcgccagtgc gaaggttgcg gagtttagag cggacaaatg ccgcaccttt 2091961 tccaggtttt acgtgctgga agtcaacgac gcgccaaatg ccgccatcta cttcaattgt 2092021 taatcctgta cggaaatcgt taactgaaat catgtttaat gtcctcctat attccaatca 2092081 caaaataata agttcttttg gggaatgggt gattgtccgg ttgccgtttt ctgtaatcac 2092141 gatgtcatct tcaatgcgga caccgcctgt ttctggtatg taaatgcccg gctccactgt 2092201 gaccaccata cccggttcaa ggatagctga agatctgacg gataatcccg gcgattcatg 2092261 aacttccatg ccgagcccgt gcccggttga atggccgaaa tagtcaccgt agccttttgc 2092321 agcaatatga tcccttgtga gggcgtcagc ctcttttcct gtcattcccg gcttaatatg 2092381 tgcgacgcca agcgcctgag catcaaatac aacctgatag atctccttca attgatcact 2092441 gggctgacct acagcgaccg tccgggtaat atcagaacaa tatcctttat aataagcgcc 2092501 aaaatcaagc gtaacaaggt ctccgctttc aatcagtttg tcactggcca caccgtgcgg 2092561 aaggcttgaa cgaaggcctg aggcgacaat catatcaaaa gaagagctgt ctgctccctg 2092621 gcttctcata taaaactcca gctcattggc aacagcgatt tcagaaatgc cgggtttcat 2092681 aaacgtcaag atatgtctga aggcatcatc tgcaatcttc gcagcttcct ctaatatctt 2092741 aatctcttca ctagacttaa tcaagcgcaa cttttccacg gattcagcca caggcactaa 2092801 ttcggcatca ctgataacgg cgctgtatga agcgtaagtg ccatatgtca tgctgttctg 2092861 ttcaaagccg agacgcttga tgccaaacga ttcaacagtg tcggcagtgg tctgaatcaa 2092921 gctgccgcca tgttcaatga tctcaaaacc ctttacctga accttcgcct gctcagtata 2092981 acgaaaatcc gtaataaacg ctgctttgtc acccgatata acagccaaac ccgccgaacc 2093041 tgtaaaccct gtcatatagc gtacattagt gttgcttgta atcagcatgc cgtcaattcc 2093101 cagctgtcca aacaggtttc ttaatttctc tagcttcatc ttgattctcc cccttgctgg 2093161 cttaataagt agcgaacagc aagcttgtag ccttcagctc caagaccgac aatctgccct 2093221 ttcgcaacag gagcgataac cgactgatgc ctgaattctt ccctggcgta taagtttgat 2093281 aaatgcacct ctaccacagg aagactgatg cttgaaacag catccctgat cgcatagctg 2093341 taatgactca gggcgccggg gttcagaaca atcccgctgt attgctcctc agcctcatgt 2093401 atcgcatcta tcaaatcacc ttcgtgatta gactggaaga aagtgagctg gatatgtaag 2093461 gcttcagcaa actgaaaaag atctgtttca atatcggtca gtgtctggcg gccgaatact 2093521 tcaggctcac gactcccaag ccggttaaca ttcggtccgt tcaaaatcaa aaaatgaggc 2093581 acacaatctc tccttttcgc gagggtttct catgtaaaaa atgttcactt ctcgtgaaca 2093641 ttttatcata ctggaaaagg attatacact attctctatg cattcccagc gcacgtgcaa 2093701 gcttttccga attcagctca ttgtattcaa atgaaataga atacccgaca aacagcccgt 2093761 aaagcaaata aatgcaaatg gtcgtaataa ttgtatctga tgtcagttcg gtcaccgtgc 2093821 gcacatctgg aaaaatcgga ttaaaaacaa aaaacacgag cagccaaagc accaagccgt 2093881 ataaaatacc cggccacatt gtttttaaac gtttcaatag aagaaaataa agaaatgctg 2093941 cgccaattga aattactcca atcaaaatga tgctgattac cgttcccagc ccatgttttt 2094001 tccactctcc gagtacaaac ggctgcaata tcatattcgg gctgatttcg gaaaaatgaa 2094061 acaaatatgc gatataagca acgaaactcc aaagtacgcc tccgcaaaaa cctgttgccg 2094121 ccaccctgcc ggccattgaa acaggcggct tttgcttctc attcaattct tcattttgtt 2094181 ctgtatcttt ttcgcttgtc atcatggcac ctccagttaa agtgtgccca aaaaatgaaa 2094241 tgtcaataaa aaagctcaca ctttttggca gctgcgagta aaatttgaaa ataacgggta 2094301 taatgcatgt agaaaaagca aggctatggc aattttttca gcctgtcaat ctagaggttt 2094361 agcgctgttt cctgtacaat agagtgaaag gaaatggtta gcaatcctaa agaaataggc 2094421 aggttgataa tatgtcaaaa cataaagttc cgcccgctta cggcgggcag gctgttgtgg 2094481 aaggcgttat gtttggcgga aagcatcatt acgttacagc catcagaaga acggatggaa 2094541 gcattgactt ttttaagctt ccacgcaaac acaacccgaa actgaacatc gtgaaaaaga 2094601 taccgttttt acgggggatc gcggccatta tcgaagcgag tgcaaacggc acaaagcatt 2094661 tgaatttttc aagcgaacgt tacgggctcg atccatctga agacgagaca cttgagcagg 2094721 aagaaaaaaa atcctctggg ctgtctatgt atctcagcct cgcagttata ggcgtcctat 2094781 catttttgtt cagtaaattc gtatttacat tggttccagt tttcttagcg gaactgacaa 2094841 ggccgatttt ttccttgaac acagcgcaaa tcgcgattga aagcctgttt aagttgattt 2094901 tgctgctcgg ttacatctat tttttgtcca tgacaccgct tattaaaaga gtgtttcaat 2094961 atcatggagc cgaacataaa gtcataaact gttatgaaca gaatttgcca attactgtgg 2095021 agaatgtcca aaaccaatct cggcttcatt accgctgcgg atcaagcttt attttattta 2095081 cgattattgt cggcatgttt gtttatttac tcgttccgac agatccgctt tggctgcgtg 2095141 ttatagatcg tgtcgcactg ataccggtcg tgcttggtat atcctttgaa gttctgcagc 2095201 tgacaaacaa agtgcgtgac attcccggtc tgaaattact tgggtacccg ggactttggc 2095261 ttcagctgtt aaccacaaag gaacctaagg atgaacaggt tgaagttgcc atcgaaagct 2095321 ttaacgaact tctcagactc gaagcattgt ctgagcaaaa tcagaagcct tctcacaacg 2095381 tcatctaaaa tccgttgccc tgctattact ttcggaggtg gacagttatg aatcatcgtg 2095441 tacaacctat tattgctgta ttaattgcgc tgggagcgtt cggtttcctc tatgtgctgg 2095501 taaccaatcc cggagaaatg gcaaaaatgg cggtaaccgt catcgtggca ggtatcatta 2095561 tttattttat tgtgaaatat gtaatgaatc gaaatgcggg cagcgaagga gcagccttca 2095621 aaaaagcggc gaaacaatca cggcgccgga tgaaagaaca aaaagcaaaa caccgcgccg 2095681 gacataaggg acgtgtcagc cacctgcgaa gcgttccgag cgccagcaag cctaagccga 2095741 tgattctcaa gaaaaaaagc cagactcagc tgactgttat agaagggaaa aaaaataaaa 2095801 agaaaaacag agcgcttttt taataggtcc actgctttaa aaacagctct gtccgtcttt 2095861 tacctagctc aatcagggct agtttttttt gttgtgttaa atgaaaatca gtggccatta 2095921 cgtcatcaac agggagaaaa atgatatttt gttcatagcg tgacgcaatg tgccttgcgt 2095981 catgagcatc cttcatcgtt tcaaacaggg cgccgaacag ttcaaaagcg ttgcggatat 2096041 tttttttcgg acgctctctt tcacgcggcg caagcgtgac accgatcaca gggcgctttc 2096101 tttcctttga aaacagccag attggaaaat tgcttaacac gcctccgtcg acaaccgtgg 2096161 cggtgcctgt gtccgttttt aattttatcg gttcaaagaa atacggaatg ctgcagctca 2096221 ttctgaccgc tctggcaacc gggaacatat ctggatttaa cccgtaacgg gccaaatcgt 2096281 ccggcaaaac aatcatggtg ccgtttgtca gatcagaagc aataaggcgc agagaccctt 2096341 tctgcaaatc gccgaaaacc cttatgcctt tcgctcttaa cagatcagca atccattttt 2096401 ctatcgtatc gcctttgtat aagccaagac gccagtagat ggacacccac tggagcatct 2096461 ttaaggggag aaatgagtac ctctgatcca gcaatttctc tccgtccact tcttcaatta 2096521 aagcgtggat ttccttactg gtgtaacctg acgcaatgaa agcggcaata atggcgccgg 2096581 cgcttgtacc cgcaactctt ttaaagcgga agcctttttc ctcaagcact tcataagcgc 2096641 ctgcgagcgc aatgcctttt actcctccgc cggaaaacac accgtcaata tacatctcat 2096701 tccctccccc tccatccgat cgtttattac cattttaaga aaacacgcga agaaatagac 2096761 caacgaatga cgggtggcgt cagcgtatca aaaaagacgg cctccttcga gaccgccttt 2096821 ttactgatta tgatgttctg ttttcttttg gattgatttc agatcttttt tacgggcatc 2096881 atcttcttca aaatattgaa caagatcccc gatgcgatca atactgttcc agcttaaatg 2096941 atgttcgatt ccttcgacat cgttatatat tttctcttca tcaacaccaa tgattcttaa 2097001 aaactgctca agcaattcat gtctgtatac cagccgtttg cctatttttt tccctttaga 2097061 cgttaacacg agaccgcgat atttttcata aattaaatat tcgtctttat ctagtttttg 2097121 aaccattttt gttacagagg agggatggac tgccaatgct tccgcgatat cggaaactcg 2097181 tgcatatcct ttttcttcaa tcagcatata aatctgttca atataatctt ccatacttgg 2097241 tgttgtcatc gaaaccctcc caaaaagcac cttaacttta taaaccatta caagtttaca 2097301 ctaatgaact tgaaaaaaca aggatgctcc gcgggtcaaa agccctgttt accgcttata 2097361 attccattca tctgaagcgt actttgtttc agccaagtga tgaacaaaat caagctcttc 2097421 ctgagaaagt tcatatggct ccaaatgaat gttaagacct gtttcaaatc cttctttaaa 2097481 ggctttacga gcctcatcca tcgtcacccg cttttcgatg agttcattaa tggcaaccgc 2097541 tttatttttg aaattgcgct gcatccgctc tcttactctt tcacttggat ataagaacag 2097601 atcgaacagc ttgtcctcat ctaaatcaag aagaatggag ccatgctgaa gaatcacacc 2097661 tttttgtctc gtttgcgcgc ttcccgccac cttgcgcccc tcaaccacta gttcatacca 2097721 cgaaggcgcg tcaaaacaaa cagatgaccg cggatttttt aagctttctt tttctttttc 2097781 agttctcggg atggcaaagt aagcgtccag accgagattt ctaaagcctt gaagtatgcc 2097841 ttctgaaata acccggtaag cctcagtaac agtcgccggc atctcggggt gctcttccga 2097901 aacaattacg ctgtatgtca gttcctgatc gtgcagcaca cctctcccgc cggtcgggcg 2097961 tctgacgaat ccgagattat atttatgtac tgcttcaaaa ttgatttcct ttttaatatt 2098021 ttgaaaatac cctacagaaa gtgtcgccgg attccagccg taaaaacgga taaccggggg 2098081 gattttcttt tcgctgtgcc aatataaaag cgcttcatca agcgccatat tgaatgcagg 2098141 acttgcattg cctgagtcta taaaccgcca agtttctttt tgcattttaa gaccttcctt 2098201 accgttttaa tagaatcagt ttatcaaact gtcgggaaaa tgaaaaatat tttagttcca 2098261 ttatagatga caatcacgct gtgctttact ataatagtat ttgtcgaaaa cggctctatg 2098321 accttgtttt atgaagcagg gttttgattt tatatgctaa aggagtagaa tcacattgtc 2098381 taatatgatc gttttgatta tttttgctgc atttatcatc tatatgattg cttcatatgt 2098441 ctatcagcag cgaattatga aaacacttac cgaagaagaa ttccgcgcgg gttaccgcaa 2098501 agcgcagctt attgatgttc gtgagccaaa tgagtttgag ggcggacata ttttaggcgc 2098561 ccgcaacatc ccgctttccc agctgaaaca gagaaaaaat gagatccgta cggacaagcc 2098621 tgtttacctg tactgccaaa acagtgtccg cagcggacgc gcggcacaaa ccctgcgcaa 2098681 aaacggctgc actgagattt acaacctaaa aggcggcttt aaaaaatggg gcggaaagat 2098741 taaagcgaag aaataaagca aacagctgtc tggtagacag ctgtttttat ttatctttct 2098801 tccgcctcgt atctgagcac tgggtgtctc gccgcttttg tttcatccat tctttttaca 2098861 atcgttgtat gcggggcctc ctgaacaagc tccggattct cctccgcttc ttttgcgatt 2098921 tgaatcatag catcaataaa cgcgtccagt gtttcctttg attcggtctc tgtcggctcg 2098981 atcatgatgc attcttcaac attaagcggg aaataaatcg tcggcggatg atagccgaaa 2099041 tcaaggagcc gttttgcaat atcaagcgta cgcactccca gctttttctg ccgcttccct 2099101 gataatacaa attcatgctt gcaatggcgg tcaaacggaa gatcgtaata aggcgcgagt 2099161 tttctcatca tataattggc gtttaacact gcgttctcag taacagcctt taatccgtca 2099221 ggccccatgg agcgaatata cgtatacgct ctcacattaa tgccaaagtt gccgtaatac 2099281 ggcttcacac ggccgatcgc atgagggcgg tcataatcaa acgtaaagcg cccttctttt 2099341 ttgactaaaa ctggctttgg caaataagga atcagatctt gttttacgcc gacagggcct 2099401 gagccggggc ctccgccgcc atgagggcct gtgaatgttt tatgcaggtt gaggtgcacc 2099461 acgtcaaatc ccatatcacc aggtctcgcc ttgcttaaaa cggcatttaa attagcgccg 2099521 tcataataca gtttcccccc cgcttggtgt acaatttccg ccatctctgt aatctgctcc 2099581 tcaaacaagc cgagcgtgtt cggattcgtc agcataagag ctgcagtttc ttcattcact 2099641 gctcttttta aatcctctaa atcaacaagc cctttttcat tcgatttcac cgtaacggtt 2099701 tcaaagcctg ctactgttgc tgatgcagga ttcgtcccat gcgcggaatc agggacaatg 2099761 accttcgtcc gcttgaaatc cccgcgagct tcatgatagg cacggatcat catcagcccc 2099821 gtccattcgc cgtgcgctcc ggcagcaggc tgaagcgtaa cctcatccat tcccgttatt 2099881 tcttcaaggt gtttgcttaa atcatataaa agctctaatg cgccttgcac cgtgtcttca 2099941 tcctgaagag gatgaatcgc agcaaaacca ggaatacgtg cgattttttc attgattttc 2100001 ggattatatt tcatcgtgca agaaccgaga ggataaaaac cggaatccac cccgtgattg 2100061 cgtttggaca gcgctgtata atggcgcatg atgtccagct ctgaaacctc cggcagcgct 2100121 gcgtcttcgt cacgaatata ggtgtctgac aagaggtccc ccaattcgat ttccggtaca 2100181 tcgagctccg gcagactata gccgattcgg ccttctcttg aaagttcaaa aataagtgcc 2100241 tggtcctgat tactcatggc gatcccccaa ttcctgaatg agtgcgtcaa tttcttcttt 2100301 tgttctcagc tctgttacag caatcagcat atggcagtcc agctctggat acgtcaaccc 2100361 aagatcatat ccgccaatca tgccttttgc cagcaaacgc ttgttcacag ctctcaccgg 2100421 ctcatccagt ttgatgacaa attcattaaa catcggcccg tcaaacataa cagtaaggcc 2100481 tgcttttttt gcttcttgct ttgcatagtt ggcttttaag agattttggc gggctatatc 2100541 ttttacgccg ttttttccga gagcagtcat ggccactgat gctgccagcg catttaaagc 2100601 ttggttcgag catatatttg atgttgcttt atcccggcgg atatgctgct ccctggcttg 2100661 cagggtaagc acaaagcctc tttttccgtt ttcgtcttcc gtttgtccga cgagacggcc 2100721 cggcaccttt ctcattaatt ttttagtaac ggcaaaaaag ccgcaatgcg ggccgccgta 2100781 tgctgaagga atgccgaaag gctgcgcatc accgacgacg atatcagact gaaacttgcc 2100841 cggcggagtg agaagaccta gcgccagcgg gttggctgaa acaataaaca tggatttccc 2100901 ttgatgagcg ataggctcaa tatcctttag cggctcgatc ctgccgaaaa aattcgggta 2100961 ctgaacgatc actgcggctg tgttctcgca aacggtttgg cgcaatgcat caagatccgt 2101021 aacgccatcc gcagcgggta cttcaacaac atcaatatac tgaccttttg cgtaagtttt 2101081 cagcacctct cgcgattcag gatgcacggt ttttgacaca acaatttttt tctttttcgt 2101141 gtggcctgaa gcaagcattg ctgcttctgc caaggctgtt ccgccgtcat acatcgagga 2101201 gttggcgata tccatgcctg tcagttcaca gatcatcgtt tggaattcaa aaatagcctg 2101261 gagctctcct tgtgaaatct ctggctgata aggcgtatat gcggtataaa actcagagcg 2101321 cgaaatgaca tgatccacaa tgacaggctg atagtggtca tatacacccg ctcctaagaa 2101381 agaagcgtat tgtacggtat cacgattttt agaggccagc tttgtcagtt ctcttgttaa 2101441 ttctgtctct gatttcgctt ttttgatttg atgctctttt ttatatttga cgttttccgg 2101501 tatatcagca aataaatcat cgatgctgct tacgccgata gtagcaagca tctcctgttt 2101561 atccttttct gttgcgggca aataacggtg cttcatgtgt tgtctcctct ctccaagaaa 2101621 aaatattagc gtttataaaa tggtgttttg acaacctttg ctttcactaa ttttttgcgt 2101681 atctctacat ctacaacagt cccgatctca ctcgtttccg aatcaattaa ggcaaggccg 2101741 acgttttttc ctaatgtcgg tgactgcgtg ccggttgtca cctttccgac agacttgcca 2101801 ttttggaaaa cctcatatcc gtgccgcggt atcccttttt caatcatttc gagaccgaca 2101861 agtttgcgct tcgctccgtt ttctttttgt tcactcaata ctgacttacc gaaaaagtca 2101921 gactcctttt tgtgctttac agcaaagcct atacctgctt caatcggtgt aatatcccgg 2101981 gtcagctcct gaccgtagag cgggagcttc gcttcaaacc ggagtgtatc acgtgcaccg 2102041 agaccgcatg gaatcaatcc gtatgcatcc cctgcatcga tgattttttt ccaaatatgc 2102101 atagcatcat cactgcggca gtaaatttca tacccgtctt ctcccgtata gccagtgcgt 2102161 gaaataagtg ctttgcggcc gctgatatcg gcttcatcaa taaacgcaaa cggctttaat 2102221 gcagacacat ccgcatctgt cagatttttt aagatcgctt ctgctttcgg tccctgtaca 2102281 gccaagagcg cgatttgatc tgactgattg tcaatctgca catcacctgc tgcatgttct 2102341 ttcatccaag ccaagtcttt atctatatta gaagcattaa tgacaagcag atagcggttc 2102401 tctccttttt gatagataag caaatcatcg acggttccgc catccgggta acacatcgct 2102461 gtatattgag cacggcctgg cgttaacgcg gaaacatcat ttgtcatcaa tctttgcaaa 2102521 aaagacagac tgtcgttccc tgacacttcg acttctccca tatgagatac atcaaacaaa 2102581 ccggctgcag ttcggacagc ctcgtgttct ttttttatag aagaaaattg aacaggaagc 2102641 tcccagcctc cgaaatcaat cgtttttcct ccatattcct tatacaggtc aaataacggc 2102701 gttcttttca gcatctaatt cctccccttt atcaacggcg cagctaaaaa acatacaaaa 2102761 aaggacagag aaacacctca tgtaaaatga aggttctctg tcctggcacc tgaaagttta 2102821 ctttgcatac gcaaagacgt cccctttggt ggtttgcgca tccgcacaaa cactctccag 2102881 agttgcgtcg agcaagagtt cttttgcctg agagattcac tccgcagttt gctccttcgg 2102941 cgcctgtatc ccgaggtttt cggtcaggtc tctccccttg ctgtcattcg ctcatatttt 2103001 catgctgtta tggacatact atagcaatat cttacatcaa atacatactc atatcctacc 2103061 atcatcacta tatgctgggc aacagcaatt tgggcagatt tttcttatat tattcatctt 2103121 aagaatcgaa gaataagaaa ggcggtttca aagcaatgaa tacagaaatg atctacgatg 2103181 caaaatggcc tgaagaattt gctgaaagac tgaaaaacga tggcccttgg gcaaactggg 2103241 aactgtacaa gctctctgca gaaatccaga aaacattagc aattccagag tttgaaggct 2103301 tacgggctcc tttatatctg ccttccttta cgccgctccc ccaccagctt gaagtggcgc 2103361 aaaaagtggt tgaaaaaatg aacgggaaag cgattttagc agatgaggtt ggtctcggaa 2103421 aaacggttga agctggactg attctaaaag aatatatgat tcgcgggtta gcaaaaaaaa 2103481 ttttgatcct tgtgcccgct tcccttgtgt cacagtgggt caaagagctt caggaaaaat 2103541 ttttgattcc ggctgttgaa caaaagaaaa gctatgtgtg ggagcaatgc gatattgtcg 2103601 tctcatcaat agacaccgcg aagcgctcgc cccatcgaga aatcgttctg tctatcccat 2103661 atgatcttgt cattattgat gaggcacaca aactgaaaaa tagcaaaacg aagaactatg 2103721 aatttgtccg gaatctcgta aaaaaatatt gcctgcttct taccgcgacg ccaatccaga 2103781 accgtatcga agagattttc aatttggtgt ccttattaaa acccggccat ttaggcagtc 2103841 agaatcactt tcaggaggag ttcgccaaga agaaatccag tttagaagcg catgaacatt 2103901 taaaagatct tgtgaataaa gtcatgatcc gtaacaggcg gcatgataca gggctgaatt 2103961 ggaaacagcg ccatgttgaa acagtgccga ttcaattttc tccatcagag caggcgcttt 2104021 atgatgaaat ttctcgtttg aaggacagta tcaataaacc agccagcatg ttctcgatta 2104081 tgaccttgca aagagaatgc tgttcgagca gagaagcggt atatatgacg ctgaaaaaga 2104141 tgcttgatca aaaagagaaa caagcacctg ccattgatga ggatacgatt tcagttttga 2104201 tagatcgcat caatcaagtg acacaaaact ctaaagcgct tcaagttgtt gacttgatca 2104261 aaaagatcga cgataaggtc atcattttta cagaataccg cgcaacccag atttatctgc 2104321 agtggtttct tcagcaaaac ggcatcagtt ctgtgccgtt tagaggcgga tttaaacgtg 2104381 gaaaaaaaga ctggatgaag gatcttttcc gcggaaaaat ccaagtcctt attgcaactg 2104441 aagcaggcgg tgagggaatt aacctgcaat tttgcaatca catgatcaac tatgacctgc 2104501 catggaaccc gatgcggctt gagcaaagaa tcggaagaat tcacagactc gggcaggagc 2104561 gtgacgtgca tatttataac atggcgacaa aacatacggt ggaagagcat attctaaagc 2104621 ttttatatga aaaaattcat ttgtttgaaa aagtggtcgg tgaacttgat gatattttaa 2104681 cgaaaattca agtgaacaat tttgaagagc accttcatga cattttgtat cactcagcaa 2104741 cagaagaaga aatgaaaata aaaatggata acttaacctc atttttgtct tataaaaaac 2104801 agctgcctgc tgaaaaaaga ggatcttagc ctgtaaggag gttttattag tgagacagca 2104861 agaggttcac gattttctgc tgcgtttttt tcaagcaaac agctgccaaa tcgtcgatca 2104921 aggcttaggc tatatgacag tgcagcttac agttgaaatg gacaaacaaa tcatgaaccg 2104981 ccctttctac tggcattggc gcgagaagac aggcggtgat ccgaatccaa tgaaaatcac 2105041 ttttattaca gataaagaaa atgcgccaaa agacctagat ggtgaattta tatattttgg 2105101 ggccccgcgt ctttttcaaa tattcaaagc tgttaaacaa aatgggagat ttaccagaat 2105161 gtatgagaaa attgaatcag ccggagctaa agtcccactt cagccttggc ttggtataaa 2105221 tgtcacgatt tcataccagt ccgacatgaa aaaggataag ttattgtcac taggtcttca 2105281 cctagtctct ggaacgataa ttgaagattt tcaaagcaag ctgacccagt tttcactgac 2105341 gtctcaaata tgtgactatt gcttcaccat ttcacctatg atcaaaccag aaagcggact 2105401 taagcgtatg gaaaactata tttccaaatc cgctatgcag gagccgtccg actgggcgga 2105461 acaggcggtt aacaggtgga agaatgatat gacattgctt gataagtttt acgagcatat 2105521 agaagaaaaa ccagaagaat accatctaga aaaacaggcg ctgaaaacct tgtatcaacc 2105581 aaagatatca gttgaaattg aaaatggcgg attgttttat ctgcaaaata atatttcaag 2105641 ctaacttttt taccattcga catcattctc gttttttttg agaaaatacg attataataa 2105701 aggtatattg gaaaaaaatt ctggtgattt aatggcaaat gacttccaga gactaatgaa 2105761 gcatacaata agtcatggcc ggactggctg aaatacataa acaagtattt taggaggaga 2105821 aactgcatga agaatgcaaa acaagagcac tttgaattgg atcaagaatg ggttgaatta 2105881 atggtggaag ccaaagaggc aaatatcagc ccggaagaaa tacgaaaata tttactttta 2105941 aacaaaaagt ctgctcatcc tggtccggca gccagaagtc ataccgtaaa tcctttctga 2106001 atgtgctata atatcacaag gaaggtgatg acattgattg gccagcgtat taaacaatac 2106061 cgtaaagaaa aaggctactc actatcagaa ctagctgaaa aagctggggt agcgaagtct 2106121 tatttaagct caatagaacg aaatctacaa acgaacccct ccattcaatt tctcgaaaaa 2106181 gtctccgctg ttctggacgt ctcggttcat actttgctcg atgagaaaca tgaaaccgaa 2106241 tacgatggtc aattagatag tgaatgggag aaattggttc gcgatgcgat gacatccggg 2106301 gtatcgaaaa aacaatttcg tgaattttta gattatcaaa aatggagaaa atcccaaaaa 2106361 gaggagtagt gcctgagcag aggcactaac tcctcttttg tcaataacca tcgagacggc 2106421 ccagtatatg aatactgggc cgtctctttt ttttgctgtt attaattttt atcctcgcta 2106481 tgcgcgagct cgtcttgctc agtattgctc attttttcaa ttttttagaa atttttggga 2106541 ttgttatgtg agaatttaaa tgcatatccc attattattt ggtaataata aacaaagaaa 2106601 gggtgacagc atgatgatca aacaatgtgt gatttgtcta tctcttctcg tctttggcac 2106661 cacagccgct cacgcagaag aaacaccgct tgtaaccgcc cgccacatgt ccaaatggga 2106721 agagattgct gtaaaagaag caaaaaaaag gtacccgctc gcacaggtac tgttcaaaca 2106781 aaaagtatgg gaccgtaaaa gaaaagatga agcagtgaag caataccatt taactctgag 2106841 ggaagggtca aaagaattcg gcgtttttgt gacgatttca tttgatcctt atagccaaaa 2106901 ggtcaataaa attgccatat tagaagaata tcaataaggt cctccatttt ttgaaggacc 2106961 ttattcgttt atttgcggtt attttttccg tttcagccaa agtcggaagc catagggtaa 2107021 aataccgaac cactgctggg aaacaggcgt ttttgtttct ttccgcacct cttttcgttc 2107081 ttttcgctca tctctcggag tatctatata tttgacaaat tgctgcgtca tatatttaac 2107141 ataatcattc gttttcacgt gatcacctca tcattcaatt attatgagtg ttgtctcaca 2107201 tgactttttt tatacccttt acactgtttt attctgtcca tctcagcagt tttttctgtt 2107261 tttggtcaaa cacgatctgt gcagttcttt ctgttcccga atccgttgac actcttaagt 2107321 tgatttcttt ttgttctttt atcgatgtat catgaatgta ataagaaacc cgtccatata 2107381 gaaattgctg cgtaccctcc tggcctttcc gttcctctag aacatgccga atcgaaagaa 2107441 gcaccccatt ttgaagcaaa ttctctccta tgtataactc ttttgtttcc ttctcaaaca 2107501 tgcagcgtga aatatattga gcagcaacaa agttcacgat taacagcaca agcgctgaca 2107561 caaaaagaac agctggataa ataaaccctc ttgtacgata cattcacccc cctcctaaat 2107621 acgaatagac tggaaaagca gtttgataca ctttttggtc ttcactctca attttcagca 2107681 aaacaacacc attttcaata tcagctttca tggcagtaat atgatctaaa atcggaacat 2107741 gccctttgcc atccactctt tttcttatca ttgaatgata aatgtcaaaa cggatgtctt 2107801 gtccggaaag attggtgcag attaacacgc tcccatgctc ggctgtctta actgcctgtg 2107861 attccttgca ttcattcatc atctgttcta tcgaaatcat ccattcctgc tgtgtgaaac 2107921 cgtcatgttc ctgctgtcga gacaaaaaca gatggataat cgcagctaac gatcctgata 2107981 tgagcaaaaa gactgagagc gaaaataata cgttaagaag cgtgtagcca ttctgtctgc 2108041 aaaatgctga ggcaaaatga tttttcttta taagctgcgg ctttgataca tacgttttga 2108101 tattcgccct cctcctccca cttcattgca tagatatgat tgttctttgt aatcgttttt 2108161 gacgcggctc cttcaccact catgacatat ttgctaatgc tctcattcat catctgatag 2108221 ccaatttctc gtgattccgc cattttttca tcagccatca gcttgtccca caaggggacg 2108281 actgtcagca gcacaaacag ccacaggctt agcgcagaca ttgtttctat tgtagaaaaa 2108341 cctttatttt ctctccacat tgactctccc gctccctaga taaactgtta tgtcataaac 2108401 ggcatggcct tttactcgta tttttccgcc tgcattcggg tgccctttct cattaaattc 2108461 caaacggtct tttaatgtca gcagttctat agaaagtccc gttgcatacg gacgttcaat 2108521 aaccgtatca ccaatgacta attgatattc ttttttatga aagagaattt ttgttctttg 2108581 ttgacgggaa atagcagtct gctgtgtgag cataatatca tttttcagct gacttgctgc 2108641 ctgtcggaca gctgtattgt cataagcagg aggaagtgta gtgaagacgg ccaccaggag 2108701 gatagaggca aggcttaaca caagcaaact ttctaaaagg gtaaacccct tctcctcgtt 2108761 taatttaatg ttcaacctta acttctccgc cggtgatgat aatgcgctta ccatttggac 2108821 agacagcatc ctttttcaca tagccctctg actgtaaatc ggcaaggctc ggagtttgtc 2108881 cttcatgatc aagctcaaat gcagtcattt gtgccttaac catgttttgt aagccttcac 2108941 agcccttttt ttgaatggtt tgattatgtt tcgtgacgtt cggtatcgta attaaaagca 2109001 aaatcgaaat aataaagagc acgattaaca tttcaacaag tgtaaatcct ttctcattca 2109061 tcagcctctt cctttcacat ttgattcatc atctgataca taggcacaag catagataaa 2109121 tacacaagta agatcatcgc tgcaacaaat ccataaatca ttggctgaag gatgcctgtc 2109181 catttttgcg ctttgtgttc cagccgctgt aatatgaatt ggctgtatgt gaaaagctcc 2109241 cgatccaatc ggccgctcag ctggccgtga gatatgactt ttgataaatc agtttcataa 2109301 aaaaggcttc cacaaatagc ggattcaatt gactcaccgg cttttagccg ttcaatcaat 2109361 tgttcagcct cgcagcggta gaaagggaga aacgtttgat gtttaaatgc attaaggctg 2109421 tcataaattg agaggcctga ttttaaaagg ctgcttagct gcaaagaaaa aaagtagctg 2109481 ttaaacagct ttacaagctt tccaaccaaa ggaatcctga tacaaatcag catttgccgg 2109541 gcaggtgatt ttttcttaaa cacaagccaa taataaatcc cgatacctgc tgtaaaaaga 2109601 acaagcaaaa tgatcacaag atcaatatgc tgaaaaaaag caaaaagcat atcggttgaa 2109661 cgtgaggttt ccatattcat cgattgatag ataccggaaa actgaggaat gatgatggac 2109721 tgtaacatat aaaacatgac agcgaccgta aagatgagga aaagcggata gcgcagcact 2109781 cttttcagct ggtctgcctg tgcaattttt cgttccagca gctctccgct ctggatcatt 2109841 gaagcaggca gttcaccatg tgtttcagca aaataacaaa tacctacggc ttccttatga 2109901 aatgacaaac tctttagtac ttgataaaac ggagcccctt ccctcaaaca agtgaccgaa 2109961 tcagtcaagt cagccgcctg cctcttattc atctgaagtt ccatcaggcg taatccatcc 2110021 agaagtgtat atccgcccgc agtcatttca ccgagcctct ttaataacct ggcttgatcc 2110081 tttaacaacc agacttttct aatctttttc atgataaacc caccggtcat agttgtttgt 2110141 cgttaaatag ccgagcgcaa ttccttttct gataatttga cgaagcgttt gatattggta 2110201 atttgcatga tttccttttg cctcctggat acattgctga agatttttcc cgtatagaag 2110261 ctcataaacg ctagctctcc tagtatttcg tgactgtcgg caatacactg atgaacatcc 2110321 gttttcacaa aacgggcaag ccaaatcaac caagcgctga gccgctattg caatgacagt 2110381 ctgttcgatt tcattcatat tgataccgaa ttcaagcagt ctgtaaattg cgccctttgc 2110441 gtctctcgta tgaaggctcg ttagtaccag atgtcccgtc atcgctgccc gcaccgcaat 2110501 ttcagctgtt tccgcgtctc tgatctcacc taaaataatc atatcggggt catggcgcaa 2110561 aattgctttc agacctgcgg aataagttac accggctttt tcattcacct gaacctgaag 2110621 aacatcttcg tcccttgttt caacagggtc ctctaatgtg acaatatttc gattaaagtg 2110681 tttttttgca tattgaacga gagagtataa tgtggtagtc ttccctgaac cagtcggccc 2110741 ggtaaaaatg agcatgccat gggaatgttt taaaaacgag agtaatgtgg ctcctgtctt 2110801 cggaaatagc gacaatttat caatcgaagg gatattgtat tggggcatca ctctgatcac 2110861 gaggctttct tcattaattg tgggcagcgt tgacattctt aaatgaacat ttccctcttt 2110921 caactttaac gtaagcgaac cgttttgcgg ctttcgcctt tcacctatat ccattgctga 2110981 aagaaattta aaatgtgaaa tcagtcttac gcactcttct tttttcatgt cccttttttt 2111041 cagcaaggca tgatcgaccc gaaaatgaat gatagcgtcc cgctccctcg gcacaatgtg 2111101 aatatcagaa gcctttgtta gatatgcctc ttcaatcaag tttttgctta ccttttctat 2111161 tgaatccaat ttgattccct ctcctttcaa cgcatattgt agaaaaagaa gaaaaggtaa 2111221 tcaaacaggg aaaacgtgat tttgtgagat gttatatgct gaaaaaccaa ttctttctgg 2111281 caagaaaaaa gactttcaac tgaatgtacc cctgtcatta taattttccc tataaataaa 2111341 aaagcagaca tggtcaccat gcctgctaga ttccattttc attatgctgt tttcgcttat 2111401 tgaccagtat ctttctcaac ggaaagatcg cctaatgcaa caataccggt catttggtca 2111461 ttttcaagaa tcgataaact gcggatttaa tgctctgtca taagcccctt gacatcgtat 2111521 ccggtcaccc tgatatgtct ggtgaaaaag cggggcacgc tgcacaaaat atgaaacatc 2111581 ctatagagtc cgcctttttc gaggtttctt tttcttcttc cgctcctgca gcatatctcc 2111641 cgtccagcct ttttttctca aatagagata gatcagaact gtagatgtga caatcaataa 2111701 gagggaaaag agatatccgt atttccaatt cagttccggc atcactgaaa agttcatccc 2111761 ccataaggca cccagagctg taatcggagt aaaaagcgtc gtgaaaatgg tcagcgcttt 2111821 tacaatttca ttccccctat gtgaggtaat gacttcctct gaatgcagca gattgttaag 2111881 ctccccttca aattcgctga tgtatgtaaa tcccctgtca atcttcagtt gtgtccgctg 2111941 ataatccttt ttcccttcat tttgaggtaa aaaggtttct ttcaacgcca tttcaatttt 2112001 tttagcgctt aatatcaaat ttttccaaat catcagttca tggcgcagga gatggacgcg 2112061 gtttaaaatg cttttgctat tgtcgtcttt aatttgccat ctgagctttc tcagcttgac 2112121 ttcaaattca tcaacaccga ttaaatacgc attcattagt tcgccgagaa gaattaaaaa 2112181 cccctctatc gcattgtccg ctctttccat ttgccgaaca acttctttgc ctttaatctc 2112241 tctcaaaatt gaaaagtcaa agttgattgt aaaaaaatat tgtctggtga tataaaagtg 2112301 aaaaacagta tggtcttttt cttcaccaag cccctgatca taaacaatcg acccaaatac 2112361 tgcttcattt tccgtttcag ttgtatctac tcgcaaaaaa ttaacgtgat ggttattttc 2112421 aaaccacttt tcacactgag gccagtgaga aaaatggatt agatctcttg ccttacttct 2112481 ttcttgaggc cccatttggt accaaaacca atcctttccc gtatgtgcct tcatgtcaag 2112541 ctcctccaaa cttttgttct ttattcttta attgcccaat aaccgcgtca ctaaaccagt 2112601 ctgccgcttc aacacatgtt ttatgagcat tttcaggtgg tatggaatgt agaaagacat 2112661 cggaaaaggg aggtgcatgc cttccttgga gaaggcagtt gttttggaat ttatcaattt 2112721 actagcagtc gctattctca ttttgttaac aggatttttc gttgccgtag aattttcaat 2112781 cgtaaaagtg cggcgatcca aaattgatca gcttgtcgca aaaggaaaga aaggtgctaa 2112841 agcggcaaag catgtcatca ctcaccttga tgaatattta tcagcctgtc agctgggcat 2112901 cacagtcgca gctttaggac tgggatggct tggggaaccg actgtgcaaa ctctgcttcg 2112961 accgcttttt cataaagcag gcttaaatga atcgcttacc cacctgcttt cactcgtcat 2113021 cgcattttta gtggttacgt atttaaatgt cgttattggg gagctggcgc caaagagttt 2113081 cgccattcaa aaagcagaaa gcattacctt gttgttcgct aaaccgctta tttggtttta 2113141 taagatcatg tttccattca tttggctgtt gaaccactct gcccgattga ttacaggagt 2113201 gtttgggctg aagccggcat cagagcatga gctggcttat acagaggaag aacttcgggt 2113261 cctattggct gaaagctata aaagcggcga gatcagaaaa agtgaattaa agtacatgaa 2113321 taatatcttc acctttgata aacgaatggc aaaggaaatt atggtgccgc gaaatgaaat 2113381 ggttagtttg tcactagatg aagactccat ttcaaatctt caggaaacag tcaagcaaac 2113441 aaaatataca cggtacccgg ttgtaagaga ggataaagat aacgtcattg gcgtgattaa 2113501 tatgaaagaa gtgctgtttt ccatgctgac gaaagatttt tcaatcaaga agcatcaaat 2113561 tgaacctttc gtacagcccg ttatccatgt aattgagacg attcctattt ataaactatt 2113621 gctgaaaatg caaaaggaac gcactcatat ggcgatcctc atagatgaat atggcgggac 2113681 gtccggtttg gtcactgtcg aggatattat cgaagaaatt gtaggagaaa tccgtgatga 2113741 atttgatgcg gatgaagtgc ctcatatccg cgaacttgga aaggatcatt acttgttaaa 2113801 tgcaaaatta ttaatcagcg atgttaacag cctgcttgga accgatttat cagaggctga 2113861 agtagacacc ttgggcggct ggtttttgac acaaaacata gacgctgagc ctgaaagtgc 2113921 catagaatat gatggctact cttttaaggt aaaagacatc aacagccatc acattttatt 2113981 tatagaagtt aaaaaagctg aatagcccgt gaaaggctgt tcagctgcta tctttcaaga 2114041 taaacatggc aaaggcatca acactctttt attttaaacc ctttattggc cagggcttta 2114101 gcaagacttt gctctgtttt cacattcgaa aaatccagac ccagcttcac gacagtttgg 2114161 gcaatttccg gcctgattcc tgaaataata gtctcaatgc cgagcaattt ggtgctgtca 2114221 atcactttaa aaatttgata ggctaccatg gtatcaacga taggaacgcc cgaaatatct 2114281 aaaaataaat acgagagctt taacgctgag cactgctcca gcacagactc caaaatcgtc 2114341 ctcgctctgt gcgtatcaat ttcaccgaca agcggaagaa tcccaattcc atcagtaatc 2114401 ggcataatcg gcgcactcaa ttcattaatc atttcttttt gcgcgtttaa ttgtatcatg 2114461 gtcacctggt gatattcttc cgtaaacact tcgatgatct catcaatgtt ttgattcaag 2114521 atccggctcc actcataaaa ttcctgaatg ctgatgtctt gagaagaagc ttcgctgaat 2114581 ttatgaatcc attcaaacat gatgtgcctg aaagtgttaa actggccgac actttgtgta 2114641 accgtcactt catgaacggc acggtctctg gcgcattgaa gagaccaccg gttgagctca 2114701 tcctctacgt cttcttttct aagggatttt gctacgatgg tcaccaataa ttcatgctgg 2114761 tcttttaact tttgttctag tttttgctga tctttcgctg aatacagcca gctgccgttt 2114821 gacgtacaaa cttccagcca ttgttgcgta atatcttttt tgtgctctgt taagtgctga 2114881 tcaagagcta tcatcttaat gagttacctc ctgtttttga aaaatgtacg ctatatatgt 2114941 ataacgcgtc tgcctttaca catactatgt ttagattcaa tgggctatag ccaagcggta 2115001 aggcaatgga ctttgactcc gtgatcgttg gttcgaatcc agctagccca gtttctgaac 2115061 aggtgaaaaa ccgaagataa gctgattcgt ataaatcagc ggatcttcgg tttttcatca 2115121 tgcagattga tgaaccgttt tcttcttcga taacttcaac agttctcccg ggttataacc 2115181 aatcaccagc tttttgttgt ctactagaat cgggcgtcgc aaaagcttcg gcttctcgat 2115241 taaaagttcc agcacctcat ttaccgtcat ttcttcaatg tttaaattta aatttttgaa 2115301 agtctggctt cttgtcgcca aaatttcatc aattccttct gtcgttaacg ataaaatgta 2115361 ctttaattct tctcttgtcg gggtttctct gaataagtgc cgttcgttaa attcaatttg 2115421 atgtgcttta agccaatgtt ttgtttttcg gcatgacgtg cagcttggat atgagtaaaa 2115481 agttaattgt tgttccattc gttttttcct cctcagttaa ccatctcttt gtagaataac 2115541 tacccggatc atttttcatt taaaccattt acagaacttt tttcggatta ttttttaaaa 2115601 aacattcata caatagaaaa cacaatcaaa gggacaaatt ccatttgtat attaataatg 2115661 aaaatgttta catttctagg tgtgatctat tataataaca gtcagaggga ctctcgggag 2115721 gggataaaaa tgaatcgcat gttccgggtg ttaggatttt ggacgggaat ttttgcagtc 2115781 atgttttatt taggtgatat gaaagatgct tcccttttat tttttggaca gacgatctta 2115841 tttgtgtttc tatcgtattt gaacttaacc gaacgcatgt atatttatat ttttggcgct 2115901 tatttaacaa ttttcttcgc cggctttaca tattactcaa tttttattat ggtgcccggc 2115961 ggcggaggcc attaaatgca gaaagagaca aaccttatcg gtttgtctct ttttttacaa 2116021 tgaaaaccca tttaaaaacg gattttgatc ctgctcagtc agtacgtctg tttcaggtcc 2116081 atggccgctt aacaccagcg tgtgttccgg aagcgtaagc agtttttcat gaatggacgt 2116141 cagcagcgtc tcttgattgc cgcctattaa atccgtacgt cctataccgc cttggaacaa 2116201 gacatctccg gaaatgacca agtctgcatc tttcacgtag taagacacac tgcctggtga 2116261 atgtcccggc gtaaataatg tttccaaatg aaacggcccg atattcaact caccgtcgcc 2116321 ttcaattaga tgatctgcag gcttagctgt gacttctatc cctcgcagca tgccggagcc 2116381 gtttaaagaa gcgtccgcaa gccaattttt ttcattttga tgcaggtaaa cagggatatc 2116441 ccatttttct ctcacttcat caagcgcccc aatatggtca aaatgggcat gtgtaagcaa 2116501 aatggctaaa ggcgtcagcc ctttttcttt tatgtattga ttgattttat gtccctcgcc 2116561 gcccggatca aaaatcagac attgatcatc actgatgaga aaatatgcgt tcgcttgaat 2116621 cggccctact ggcattcgtc tccatttcac tattatcacc tctttctttt ttatgctctt 2116681 attatgaggg tttttgaaaa aagattcaaa caatcgcaat gaaaacgcta tcgacaaacc 2116741 tataaaaaac aggtagaata aaactggaaa gaattgcagg tttttcaatg taaagggggc 2116801 tgtgttatgt tacttgtcgt gattttcggc cttgtcgctc ttttcgcttt atggggagtc 2116861 ttgcgttctg ttagaaataa aaatatactc gggtttttat tagccggtgc caccttattt 2116921 gtctttggat ggtttaccgt gatgaccgta ataaacagcg ggtatccaac cgcacattaa 2116981 aacctgtatc cgatcggata caggtttatt tttatggctg taaatgttta ttgacacttt 2117041 ctattttgct ctcaagcgtc gtttttttgt cacgcctgtc atcgatacgg atattcgttg 2117101 ccactctgtg caatcctttt tgaaatggcg cttcgtgaat tgcctgaata actgcaaaaa 2117161 ggtcactgag ttctccctcg atcagcgtat tcatcggtgt cagctgatat ttgattttcc 2117221 cttctgcttg atatccttct aatatctttt gcacatcggc tacgtaagca ctgacactgg 2117281 gtgtttccgt accgattggg ataatggtta catctgcgat agccatcgtt attccatctc 2117341 cttttgatca atgatgagtt gcttcgtttc atgtgatttc aataaaataa tttgctcaaa 2117401 atgaaagccg tataacgcat atttcccgtt cggagatatt tgaatcggct ccatttcccg 2117461 cagagacaca agatcttttg tctctcccga tgctacattg attgctgcga gcttatatgc 2117521 atcgccgctt tgtttgaatg tataaaacag gcctcctgct tcatcatagt catactccat 2117581 tggagccaaa cttgtatatt tcgcttggag cggccatttc gctgtaacag gtgatgttga 2117641 ttgcggcgtt ttaaactgat acgtcccttt tcctccggaa gctgatttga cagtaaaact 2117701 catttgatgg aaagaatcga agaatagaac gttatcctca agcttctgtt ccgtcttaga 2117761 agctgtatcg aacgtatata aaggccctgt tttatcgtct ctaccctctt ttacataatc 2117821 aaatgtattt ttggatgtcc aatgaatgaa cggaacctgt actgggctta agaaagattc 2117881 gtctttttta gcattcacct gatatgtatg gaaatcccag ttttcattga attccgtcac 2117941 catcatttga taaggatcat actgattcca agcagcttca agctcatacg tttcgtaatc 2118001 tttttcgtaa agcgtctctc cttctgcatt aagcaaaacc actgccgtct tttggctatg 2118061 tgtgatttgc agcagaatca tctgctccct cgcattgatt tgaacatcaa cgatttgacc 2118121 atccgtttga tagagctttt tcgctttgcc tgtaaagatg cggtacgcaa aaagctctgt 2118181 tttcgtcgga ttagacgcag tatataatat tgtgctgtta ttcagccagc cttccgcccc 2118241 atccgctttt tccgcggaaa gcggtatgat gtcttttttc tcatcttttg ccgccgatgc 2118301 ctgtttttgc tgctgatgag atggttcgca tgccgataaa ctaaacagca ataccgccag 2118361 cagaataaaa caaactgatc tcatcagcat tcccctccga tcatctttat tctctcatat 2118421 ttgcttcggc agaaaaaaga aaaagtttca gttactcatg aaaaaataac gccctccaca 2118481 agataccgct tgtggcgtta tatatgtgtg aaaactgctg aaacggcaaa ggattttggc 2118541 cttttccaag ttccaccgta tacccttcct taaaataatg gtgaataaac caatcacgaa 2118601 atccagcata gctgtctata tcccttactc ccttataaat gttcccgctt aactcctcaa 2118661 actcctttat gacggcagca gattcctcag gctcaaggcc tttatagccc caataaattt 2118721 cttctccttg agtatgaaga gccagcagtc tgtcaggcgg attctccgtg atcagccggt 2118781 acatcgcaat agattccggc tccgtaagcg gagagattcc cggaaaatcg cggtagctgg 2118841 gtgctgtcgg ttttcggtat ttttcaattt cccataatga tggaaattgt ttatttaaat 2118901 caaccccgtt tatattcgcc ttccattcat taaaatttgg acgatgttca tttagccttt 2118961 cgagttcatc tcttctggct cccatgactt ctgatccgtt taaaacaaga tcaacgccat 2119021 ccggattgac aagaggaacg agggataagg atgtgctgtt aaacagcttt atgggagaaa 2119081 agccaaagaa aggcgaattg cagcataatg acatacagta ttccttaaac cattttagca 2119141 ggacagacgt tgtaatccac tcattcgcat gaaatgacgc gttcatatgg acctttttta 2119201 cggcatgctc cccaccagcc ttcagctccc agataggcct gccgagtaca gaacggccaa 2119261 tttcccggca tgagacaaac ggaaaaacat caataatctt ctttatttcc ttttcaacag 2119321 ctgaatcatc atagattttc tcttgctcaa tccagctatc tgaaagtttc agctgccgag 2119381 gctgtaaaaa gcgctttatg tcctgaatgg tttgaagctc tttgccgcta tgctcctcta 2119441 tcacataacc agggcaatac aattgatgtt tttgtgcgga gcgatttgca cttttaagca 2119501 attcctcgtc tatcttcagt tctttcgcca cattggccaa attgttcttg atctcaggtt 2119561 tcaccgtaat aaacgccatc atcatccccc ttttttgtta ctatatgaca gcgtatttaa 2119621 aaaaagaaag cctcccgctc acttcgatgc gggagacatt gtgattatga tgcctgatca 2119681 agcatttgtt tttctttccg ctttgacgaa ttgtccagcc ttttctggtc ataaaatcgc 2119741 aacaaatccc cataaatgat ttcatcagaa agtgatagct cctgttttgc tttatcagca 2119801 aatgcttcac attgttttgt ctcttctaac ggttttcccg tctctttgtc ataacacgca 2119861 ccgtctgtat aaacaacctg atctgtgata aagctcccgt cccggagcac cgtgaagtcc 2119921 agtttttcgt ctgaaagcag atcgttgccg aattgaattt gatctttcgt atcaatccct 2119981 aaaagattca tcagcgtcgg cctgatatca atctgcccgc ctactgtttc aatggtttgc 2120041 ggctttttat cagtaatacc cggaatatga atgaccagcg gcactttttg gagctgtacc 2120101 tcttcaaatg gggttatttc ttttcctaaa aactgcccca tcgcttcatt atggttttct 2120161 gatataccat aatggtcacc atataataca ataacagagt tgtcgtataa cccgtcttcc 2120221 ttcagctttt cgataaaccg tttcagcgcc tcatcctgat aacgcactgt cggaaaatat 2120281 ttatttagcg tctggctgtt tgaatcatat tcatcaatca attgatcctc ttcatcaaga 2120341 tcaaacggga agtggttcgt cagtgtaatc agcctcgagt aaaacggctg aggcagattt 2120401 ttcatcagct ctgaggactg ctcaaaaaat tctttatcct taagtcccca gccgactgaa 2120461 ttttcgtcag ttacatcata cgagttaata tcaaaaaacg aatcatatcc aaatgagtcg 2120521 tacattaaat cacgattcca aaagctctta ttattagcgt ggagcaccgc tgaatagtat 2120581 ccgctgtttt tcaaaatttc aggagcggcc atatattgat tgcccgcatt cgtaaaaaat 2120641 acggcacctc gtccaagcgg atacagtgaa ttgtccacga taaattcaga atccgaggtt 2120701 ttcccctggc ctgtttggtg gtaaacatta ttaaagttgt agctctgttt tataaagtca 2120761 ttcagaaaag gcgtgatttc ttctccattc aatttttcat taatcacgaa gctttgcgtc 2120821 gactctaagg atacgagaat gacgttcctt ccttttgcag cgccgaataa gcgtttgttg 2120881 gcatccttcg cattagcggt tacgtagttt tcaatctccg tcaggctgtt gctgtctgcc 2120941 aacgctctct gtgcggattg ctttgactga agaacgccat cgtaaatatg aaaattaaac 2121001 aggctaatgt ttttaacaag catttctctg tcaaatgagc gtgtcaatag ctgaggtctt 2121061 tccgcctcag acaagcccag gttgaagaaa taaacagaag caacgaacaa aaaataagcc 2121121 gcccgttcat ttttcgttga gggaatgtcc gattgaaaag ctttttgccg gatgtgaagc 2121181 catattaaaa ccgcaatatc tacagctaat aggaggtctg tcggctcaag aagtgttccg 2121241 atgctgcttc cgagatcacc catattgctc gtttgaaaaa gaacagggat tgttaagaaa 2121301 tcattgtaaa aacggtaaaa aaccatattt gccagcaata caaacgtgac aagacagctc 2121361 atcgcgataa tgtagcgatt tctgtttttg ccttttaaaa acaggctgag gccaaaaata 2121421 agcaacaaaa aactcaatgg gttgataaac agaataaatt cctgtgttag attgtcgatt 2121481 ttaatatgaa aactggtttt gtaaacagca tacgttttca gccacatcaa taaaatggca 2121541 atcagcataa atgaaatctt cgaaaaaaac gtttttcgca tttcaacctc ctatgcagca 2121601 cgctcaaaaa aatcagtcta ttcccaacat tctcattaac acatcaaatt aaatcttaac 2121661 ctgagcacaa caaaaaatca atttcattta cacaatttta acaattttga tgtttcagcc 2121721 attcattttt agcgatccaa gcgcctccga taacgccggc atcatttcca agtgctgcga 2121781 ttgaaatatc agcagcttgg gctgcccgcg gaaacgcgca tttgcggaat gttttctcga 2121841 cttttgatct cagcagttct ccggctctcg atacgccgcc gccaagaacg attttggatg 2121901 gattaagcga gcttgccaaa tttccgagca ccaaaccaag atgcttggct acataatcaa 2121961 ccacctcaag ggcaatttca tcattttcac ccgccgcttc aaacacatct cgcgctgaca 2122021 attgttcggt tgcttttaaa cgtgtcgtct ttttagcatt tgctattttt tcttttgcaa 2122081 ttcttacaat tccggttgct gacgcaattg tttcgataca gcccgttttg ccgcagttgc 2122141 agggcgctcc gccttcaggg atgctgcaaa tatggccgat ttctccgccg gcgccattta 2122201 taccatgtac aatttcacca tttgcaatga tgccgccgcc aactcctgtg ccaagcgtca 2122261 cgagaatgac gtcttttgcg ccatcacccg ctcccttcca catttccccg agcgcagcaa 2122321 tattcgcgtc attttctata acagctggga tgccggtttc tgtctccaga tggtttttca 2122381 aagcataatt tttccaccct agatttactg tttcataaac cactcctgcc gccatatcta 2122441 cagggcctgg tgcacccatt ccgatgtatt tgatgatgtg cttcggtttt tgcagctcat 2122501 ccagcttgct gtcgattgtt tttgcaattg tgacagtaat cgtgtcgccg gttttatctg 2122561 tcggaacttc ccacttatgc tgaatttcgc catattgatt aataaaagcg agtttaatcg 2122621 tcgttcctcc caggtcaatg cccgcaaacc atatctcgtc catttttatc accttagcct 2122681 ttataaaaat ctcttccgtt ttttgtttgt tccaattctt ttcgaaggac agctgccgct 2122741 ctggcccact gctccttttc aatcatgtgg ttcatgtata attcctttaa ttcatccagc 2122801 ataaactcaa tttcaagctc tctgtctcca aaataaacaa tgtggccaaa cgtttttaac 2122861 agctgctgca catcataaaa tgtattcatt ttcctcacca tttcttgaac ttaactatca 2122921 taagcgtatt cataaggaag cggtcagtca agaagaaaac gctgacaaaa aagccagctt 2122981 cctttccata ttccacctct atgattcttt attgttttca atttgccgct gcagctcctt 2123041 gtagcgctgc tccttcggct tcagtttcac agccgtctgg atggcctttt ctgcttgtgc 2123101 aagctcattt ttttccgcat acaataacgc taaattgtaa taggaagcat ggtctttagg 2123161 ttcttttttc actgctcgtt ccaaaaggga aaccgcctga tcatattcgc cgatttgaat 2123221 atcagaaaca gcaagaattt tcaaaagatc ggcagaggca tctttttgcg ctgcttctcc 2123281 gttcagcaat tctgttactt cttcatactt tccttcctga tacagctcgc ttgcctgctg 2123341 aatcagcgct gactcctggt gtgaaggcga atgcaatccg taatataaaa atccaacagc 2123401 caaagcaatc agcaaaaccg ctgacaacaa tctttttcca aaggctccgg ctttaggcaa 2123461 ccccagtgct gctgcagcga aaaagccgcc aatcaagccg ccgatatgtc ctgaattatc 2123521 aatattcgaa accgcaaaac caaagcccag attgatgata ataatgacaa taatattggt 2123581 tcctatagtt cttaaaaaca tttttcgatt agacaaagca acatacagta atgcacctaa 2123641 gcatccgaat atggctcctg atgcccctgc cgaaggatac gggctgaaca caaaactcgc 2123701 aatcgaaccc gtaatgccag cagccagata aatcagcaaa aatctccccg atccatacat 2123761 ccgctcaacc gctgtaccaa ccgaccataa agccagcgta ttaaaagcta aatgcgctat 2123821 gccgatgtga agcacgatcg gtgtcagaag ccgccaccat tctccttgtg caatcaggct 2123881 gttttctttt gctccaaaag ccaccagtgt ctccgtatta gtgctgcctc cgtttatttc 2123941 gagcaagaaa aacatcagga tctgaagcgc aataaataaa tatgtaaaag tcggttttcc 2124001 gttttgaaaa accgccgctt cagtttttct ctgttcttct tgtttcagca ctagcgaaag 2124061 gaagcgttct cgcgccattt gcgcgttttc aaacgaagcg tgttcctctg aacaatcttc 2124121 tgtacgaaat gatggaaaaa ccgcttgaag atcatctcga agcatcgttc ctctaacgat 2124181 cgccggctca actgacacag ttcccttctc aaaagttttt tttgcaatct cttcccagtc 2124241 atcaactggg gcttccgttg aaaaaaacac gttcagcagc ttcatccttc gtctgcccaa 2124301 ttgatgtctg actcgttcta ctcgttcggc ctgctcttcg atgtctctaa ccatttcttg 2124361 acggaaatca agatcgtgct tataaagacg aactagatca tgagaggact tgtccggcgc 2124421 ttccagccat atttcatctg actcaccggc ttgtatgacg ccatacccgc tattcaccag 2124481 gtgcgccgca attttccaat atgtatactc cagcaaaaac atgtttaccg ctccaatagt 2124541 tttttttcat tataacagct ggcgctccga aacgcctact gaaagcaaaa aatcccgttt 2124601 ttcacgggat tttagaaagc ttgctgtata aacttattgc ggataaatgg aattcttaaa 2124661 aacaaatgga taaaagaccg cctgattcct ggctggctga gtacagtatt cataagacgg 2124721 tagcgatttt gataaaacat gacggcagaa accgcgaaaa tggcatatat caaaagtttt 2124781 ttcatgatat ccctcctgcc aatagggttt gttattctac cttatttatt ctcgaataag 2124841 ggacaggaaa gttatgaaaa acaagaaata atccgatcct ctgttatcag cttatgtacc 2124901 gggatgtcat gcggcagacg gggtacgtgc gcaaacaact ggcactccaa aagcaaagag 2124961 actgtcttcc cttcatattc acttaaatag cgatcataat agccgcctcc aaagccgacc 2125021 ctaaacccgt taacatcaaa acaaacaccc ggaacgatca tcaagtcaat ttgtgatggg 2125081 tttacttctt ttgttttttc aattaccggc tcgagcagtc cggcgtacac ggtttcgagc 2125141 tgatcatcag tctgatatgt gcgaaattgc attttcttcg tgtccggatg gcattttggg 2125201 atgcaaactt gtttcccttc ttcccaagcc tgctcaatga caggacgcgt cggtatctct 2125261 aatcctctgg aaatagtgac ggcaatggtg ccggcatttt gccactccgg cagagaaaac 2125321 aagtacttat acatacgttc cgttttttga agaatatctt catttgataa agcagacagt 2125381 gcctccagcg tcttttttct taattgtgat ttcatctctc atccccctcg gaatagaaaa 2125441 aaagccagaa cctttttcaa agctctggct tttttcttac acctcaaaca gcaaagctgt 2125501 tattttgttt cacggtgtaa cgtagatttt ttatcacgtg ggcaatattt tttaaattca 2125561 acgcggtctg gattgttgcg tttgttcttt ttagaaatat agttacgctc accacattca 2125621 gtgcaagcca aagtaatatt aacgcgcatt attttccctc caaactaaaa tcatttactt 2125681 attcagactt atatataata ccactataat ggacggaatg ctaggctgtt tttcaatgaa 2125741 ttgctgaatt attgaagata cgctcataaa gctgcaaata tgatgacata atgagtcggg 2125801 ggtggtggag cttgaacact tgttgtctgc cagcttcttt tatccggcgg gctttttccc 2125861 ggtcttttaa aaaactgtcc agcagatcag cagcttcctg tacgagcgta aaatcagcga 2125921 tgattgccgt tttgtcatga accgcataat cacaaaaacc acctgactga gaaacgacag 2125981 tcagcacacc ttgttccatg ctttcttgcg cggcaagccc aaacggttca taagaactag 2126041 ggaaaacagc catttcacag tgagacagta acgttctgat atctttccta tttagaaacg 2126101 gcagaaacat gacgcgatcc ttcaggttat atgccgcagc caatttctca tagcaggaca 2126161 gagacggccc ctccccagcc agcactagat agaggtcagg ctgacgctgc ttcaagatgg 2126221 caaacacctt taacagctgc gataatcctt tttccggaac aaaccttcca tatgaaaaga 2126281 ggaatcttct attcatgctt ctcgggattt tccccttctc ttcctccata gatgcagggc 2126341 ttgggataac ggttattttc ttatgtgccg ccttatcaag agaccgcttc ataaatgtgc 2126401 ttaatacgat caatgcatca gcggattcta taaggagccg ttcggtcatg agcctgtatg 2126461 ggtgtggggc ttctcggcac accttcttcc tttcgctttc aagaccgtgg attgtcgcag 2126521 caagcggaag gccaagccgt tgtttcaaat actgggcggc aggggcagtt gtgtcatcat 2126581 gggcatgaat cagatcaaag cgtttattgt gtgataacac atggcgaacc attgtaaagt 2126641 tagcatcagc tatgtaatct tcaaacttcg catacgaaaa cagctgcccg ctcggagtaa 2126701 aaaccgtaat gttgatatga gggtttaaat aggaaatgag gcggtttaaa tggacaccga 2126761 gcccgctttt cggctcatcg ggatgttcgg gtgaaagcat gagaatgttc accgttcttt 2126821 ttcccctctc ccataacagg tgtatgcaga aaattgcgcc tcccacctgg tgtgcgcttc 2126881 ttcaatctga aaactgttta tatgacgaat cccattttca tcaagataga tgtcgtctgt 2126941 accggcaagc ttgagagaga cattcattga attcacaatt ctgtattcag cccgatatac 2127001 agcatcacca gccgcctgtc taatcgtcca ttctccttta tcatacgttg tgcgttttgt 2127061 cctgacagct tcaatgtctt ttcttttgat gacaatgcgc aattctttta tcatatcctg 2127121 cgttttttcg aaaaggaccg cttcagccag ccgcattgtt tcttctgaga tttcccagct 2127181 tacggtcaag gtgtgagcgt tttgaatgat tatgtcgaat gtgtccctaa aaaaggaaag 2127241 cttatgtcgt atattatagg gaaatgggtg tttatccatg gactcctaac attctccttt 2127301 ccaatcgttc acttcgtgtt cctattaaac cattacatga agaagaagcg aagaaagatt 2127361 tctcgacaaa atctcgtttt tttcgcgaat tcctttagaa actattggtt ttatggtata 2127421 aaaaagaagg ataaaaaaag aatagaaggt gatgaaacgt ggaaattgct attattgcgt 2127481 tgtttatcgt cagtatagcg ctaattgcat tctcatattc tcaaagagac ccgatgaaag 2127541 atgtagaaca ggagctcgaa acactgcagc tttctgcgat gcaggaaatt tacaagctca 2127601 aaaagaaaat gacagtgctt gaggaagaat tactggaaac aaaccttgtc attcgcaaat 2127661 caaagcagaa cgacatcaat caaaaaatcg ctaaacaaat actttctaaa tataataacg 2127721 gtatgtcagc tgaagcgatt gctaaagctg aacatgtatc agtggaagac gtgaatacga 2127781 ttatcaaaga taatgagaag gtgctcgtat gacaaaacgg ggcattcagg catttgctgg 2127841 cggcatcatt ttagcgacag ccgttcttgc agctgttttt tatctgactg acgaagacca 2127901 ggccgctgct gtaaaagata ataaaacagt aaccgaacaa gacgtgaaca attatcttga 2127961 ttctaaaaaa ttggtttctg tcaaccgtga tgaatatcaa aaacttctcg attcaaaaga 2128021 gaaatcctta aacaatgaca gcggctcaga cacgaaatca gacaaagtca aaacctacaa 2128081 gctcaccatt aaagacggca tgagcacggc ggatgtatct gctattcttg aaaaagaggg 2128141 cattatctct tcggctcaag actttaatga ctatgtcatt gatgccggct atcacaaaga 2128201 aattcgtgcc ggcgagttta aagtaaaatc agacatgagt ttcaaaaaga tcgtaaaaac 2128261 gttaacacga taaaaaaaca ggctgactca gcctgttttt ttcatccaaa ctttcctgaa 2128321 atgtaatcga gcgttctttg gtccttcggg ttagagaaca ttttattcgt attgtcgcat 2128381 tcaacaagct cgcccatgta gaaaaaggcg gtttgatcag aaacccttgc tgcctgctgc 2128441 atgttatgcg tgacaatgac aattgtatat ttatctttca gctctagaat gagttcttca 2128501 atttttctcg ttgagattgg atctagtgca gatgtcggtt catccatcag caaaatatca 2128561 ggattggtcg caagtgctct ggcgatgcaa agacgctgct gctggccccc tgacagcgaa 2128621 agagcggacg tatgcaatcg atccttcacc tcatcccata acgccacgtc ttttaatgac 2128681 ttttccacaa tttcctgaag cttcttctta tttttggtgc cgtggactct cggtccgtaa 2128741 gccacattat caaaaataga ttgcggaaac ggattccctt tttggaatac catgccgata 2128801 ttttttcgca aatccacgat gtccacttta tcctttaaaa tgttgctgcc attatagttc 2128861 agctcacctg caagctttac attcggcgtc atttgaatca ttaaattcaa tgtcttgata 2128921 aaggtcgatt tcccgcatcc ggatggtccg ataatcgccg taacctcatt ttcataaatg 2128981 ctcaaattga tattttttaa agcatgatgc tgcccatacc ataagttcat tccattgact 2129041 tgatatactt cctgtttcat tacagcttcg gtagcaatac tcattgccgc cctcctatcc 2129101 gaatttcccg ttaatataat cctctgtctt ttgctttttc ggactcgtga aaatctgttc 2129161 ggtctgtccg tattctacaa gctcgccgtt taaaaagaat gccgtccggt cagaaacccg 2129221 cagagcctgc tgcatattgt gcgtgacaat aataattgag tattctcttt tcaatcctgt 2129281 aattaattcc tctatttttg catttgaaat cggatcaagc gctgaagctg gttcatcaag 2129341 cagaagaaca gccggcttca tcgcaagcgt tctcgcgatg cataaacgct gctgctggcc 2129401 gccggataac gagagtgcgg atgaatgtaa acgatccttc acctcatccc agagcgctgc 2129461 ttttgttaaa ctttcttcca caatttcatc taaaacagct ttattccgct ctccggcata 2129521 tttcaatgca tgtgtgatat tcgcatagat cgatttcgga aatggatttg gtttttggaa 2129581 aaccattccg atttctcttc tcaagctgac aacgttaata ttgccgccca atatatttaa 2129641 tccctcataa aggatttcac cttccgctct tgcagatgga attaaatcgt tcattcggtt 2129701 aatatttctc aaaaaagtag attttccgca tcccgacggc ccaattaaag cagtcaccgc 2129761 atttttttca atatccatgt ttacatgatg aacggcttgt ttatttccgt aataaatgga 2129821 cagatctttg acctcaagca cgtggttctg cttcggaaca ataacagctc gctcaggttt 2129881 ttcttttacc atttgttcag acatgttttt cgcctctttc cgttctaatt tgccgtaagc 2129941 tttttgtaga tcatcgtgcc aagccatctc gccgcgagat taaacacaag aacagaaatc 2130001 accagcacgg cagaaccacc gttggcaatc gcttcagcat ccggaatcat tccttgtgta 2130061 ttgacgttcc aaatgtggac cgcaagtgtt tcagcgggcc tgaaaatatt aagcggtgat 2130121 gtttccgaaa acgggttcca ctccgtaaaa ttaagacgcg gtgttgtcag gcctgccgta 2130181 aataataatg cggccgcttc cccgaacacc cttcctgacg ctaaaattgc tcctgtgatg 2130241 atagaaggaa tcgcacttgg aattaaaact gtttttacgg tatgccagcg tgatacacct 2130301 aaagcgagag aggcttcctt cagatcttta gggactgaac ggatcgcgtc ttctgtcaca 2130361 cgcaccatga caggaaggtt aaaaacagtt aacgcaagcg ctccgcctat gatcgtataa 2130421 ccccagcctg ttaagttgac aaacatcaat aatccaaaca tcccaatgac aatagacgga 2130481 agagatgaaa gcacctctat acatgttcta atgaagtcag ttactttgtt attaggcgcg 2130541 tattcagcca tgaagactcc gccgcccaca ccgagcggga ttgtaatcag cattgtaata 2130601 aacaaaatat aaaaggagtt aaacagctga tctcgtatgc ctcctccagc tgcaatggcg 2130661 ctcgactttg ttgtaataaa ttgaaaactg agctgagaaa caccgtttat aataatatag 2130721 gaaaacaaac ctactaaaat ggcagcgata atggctgcac acaaaccaaa cattccggtc 2130781 gccagtttat ctgttatttt gcggttcatt acactttcct cctagatgac aagtagcgaa 2130841 taagcaggat gaacaagaat gacatcacca gaagcacaag ccccattgac cacagcgtat 2130901 tgttttcaac acttccgtat gtggtgtggc ccatattcag cgtgatgatc gttgtcagcg 2130961 ttcccgcagt gtcaaacggg ctttccggca atactcttgt atttccaatg accatctgaa 2131021 cagccaaagc ttcaccgaac gcccgagcca tgcctaacac aacagctgtc atcaatgttg 2131081 gaaaagctgc aggcacaagt acttttctga tcgtctgcca tcttgtggca ccaagcgcgt 2131141 aagaaccctc tcgtaaactc ttcggaagag aagccattgc atcagcagaa atcgatgtga 2131201 tcgtcggcag aatcatgacg gaaaggacaa tcgttcccgc caataaactg tgccctgttc 2131261 cgctcgattt gaactgggcg ataaacggca ccaatactgt aagacctatg aatccataaa 2131321 caacagatgg aataccgact aaaagctcaa tcaccggctg cagcactttc tttccccaat 2131381 tcggggcaat ctctgtcata aaaatcgcac ctgcaatgcc aagcggcgca gcgattagag 2131441 cagaaagaat cgttactgca aatgagccaa aaataaatgg cagcactccg tatttcggat 2131501 cactatctgt aggattccaa tttaagctcg ttaagaattc aattgggctt acaccattta 2131561 caagaaaaga ttgcagcccc ttaacgccga ggaaaatggt aatcgcaaca gatgccgcaa 2131621 tcataatcag tgcacaagct gtgactatca ttcttccccg aacttcatcc aattgccgat 2131681 tttgcctaga gctgattaag cgctcgctca cagacatatt ttctctattg tttatcattg 2131741 ttttacactc ctatgaatgt gttaagagga gaaacggttg tccccgcact cctcttttta 2131801 ttaagatcag ctttgcttcc cgttggcatc acgtgtcact ttcatatcag taaccggaat 2131861 gtagccttgg tcagtaacaa tgcttttttg aatgtcttca ctctttagat aatcaagaaa 2131921 ttctttagct aaacctgtcg cttcaccttt tgtataagaa tgttgataag cccagatcgg 2131981 atactcgcca gttgctacat ttttcgcttc aggtttaaca ccgtcaatag atagagcagt 2132041 tactttgtca tctgttaaat atgagaatgc aagatatcca atcgctcccg gagtatcagc 2132101 aatgatcttt ttcaccgtgt tggaggaatc ttcagtaatg ccttctgcag gctccgctcc 2132161 gtcaagcgca tatttcacaa atgtagcacg tgtgccggaa gaatcagggc ggtttacaag 2132221 tgtaatcttt tggtctttgc cgccgagctc tttccagttt ttgattttgc cagtgaagat 2132281 ttttttcaat tcatcttttg aaatatcctt tacaccagca tcagggttta cagctgctgc 2132341 cataccaact acagcgactt gatgatcgac aagcgctttt gcatcgatgc cttctttttc 2132401 ttcagcaaaa acgtctgaat tcccgatctg aacagctcct tcagagactt gagaaagccc 2132461 tgttccagaa ccgccagctt gtacctgtat atcagcatca gggttttctt ccataaattt 2132521 ttccgcggct gcaagtacta gtggctgcat tgccgatgaa ccagaaatgg ttaaagaacc 2132581 tgatgccttt tcttctcctt ttgcagaatc gctattcgat tttttacttt ctcctgcatt 2132641 tccgcatgca gctgcaatca tcataaaagc agccatcaga agcataagca ccaatttgtt 2132701 ttttttcatt tcctgaattc cccctgcgta taatgtgtaa tttgtcctac acgtatagag 2132761 taaaggttct atgtaaaaag ggtttgaacc gaatgttaag gttttgtaaa tcagtgcgtt 2132821 tttttgtata aaaaaaacgc ccacatcatg tgagcgtttt tttttagtta tcagaagacg 2132881 ttgtgttttc tgcattttct tcaattttgt ctttattctt ttgctgagta ccttctttgt 2132941 cctgcttcga tttcagctca aaatatttat ccattacttc cctgccgatt tcgtttgtaa 2133001 ttgagtatct ttgattgtaa tcaatgtaag tccaaggaac tacgacagaa atagcaatct 2133061 caggattgtc agctggtgca taagccacaa gcgtcgtatt ataagtgtct gttcctgttt 2133121 ttgatttatc cggtccgtcg taaaatgatt gggctgttcc tgtttttgca gctggtttat 2133181 acgatgctga agccagttga cctgcagctg tccctttagt ggcaacccgt ctaaaaccgg 2133241 cttggacctc ttcaatatag ctactcttca tatcgacttt attcaatact tcaggctgaa 2133301 cagaatcaac gactgcgccg atcccttttt tcgcatttga atctctgact tcctttacaa 2133361 gctgaggctt catgcggtag ccaccatttg ctatggtgga gacatattga gccaattcca 2133421 gcggtgtata agtatcatac tgtccaatgg cgaaatcaag caagaaacca gataatctgc 2133481 ttgtaccttt atatcccgtc atttcatttg gtagatcaat tcctgttttt actcctaatc 2133541 caaattgact gaaataattt ctgaaggtat caaatgcaga agtatccaaa ggcaatgctt 2133601 ggtgaggttt atattcacct ttaccaactg caattgctgt tttaaacata aaaacgtttg 2133661 atgacttctc taatgcagtt tgaataccaa ccggccctaa gttttgccaa gattttttcc 2133721 ctcttttatc ctggccgata tacaatggtt catccttaaa tacagtattc aaattaatcg 2133781 ctccagtttg aagaccggtc aaaacggttg caccttttac agctgatccc atagcgtagg 2133841 atgaagtcat ggctcctaat gcataatcat caaacttata ggctccattt tctcgtttaa 2133901 tctgcttccc tgccattgtc agcacttcgc cgtttctagg gtccatcatg acaacgaatg 2133961 cacgatccaa caattcggta ctaggtcttg ctttagcagc tttaagtttt ttctcaataa 2134021 ttttttccac tgatttttgc aaatcaatat caattgttag tacaagatct ttcccggctt 2134081 tgccttcaga taccgttttt gttcccgtga cattgccttt tgaatctgtg atattttcga 2134141 cttttgcttt ttggccctgc agaaggcttt catattggta ttccagatag ctttttccga 2134201 ccctgtcatt tcggctgtag ccaagcgaca gataatggtc gagcaagttg gacggcaatc 2134261 cttcattaga gctggaaaca cttccgagca ctgagcgaag aaggttttta taaggatatt 2134321 cacgttccca atcggacgtg acatcaacac ctggcagttc gtctaaatgt tcacttacca 2134381 ctgccatttc cttcgctgat acatcttcgt ttttgatata ttgaggggtc aatgcatagc 2134441 ccgaatccat ctgtcttttg atagcaagga tctgcatatc tttatccgtc aattcattca 2134501 gctgcttatc agtaatccgt tttagctgaa gctggtataa atcgtcatcg gatatttttt 2134561 tgtcttcaac ctgctgtctt tctttagagc taatgagctt tttcgcttct ttcggtctag 2134621 tcaaaatcca ataatctttt ttatcccgtt ctgttacttt ttttgtatcg actttgatca 2134681 tgtcagacag cttttttgcg atctttaagc gctgttcttg cgtggtcgat ttagatctcg 2134741 tgtatgtgat tgcatttaaa gccttatttg tcacaatggc attaaagttt cgatcataaa 2134801 ttttcccgcg tggtaccgct gagctgactt cactttgttc ctgcttattc gcttggtttt 2134861 tgtaatcatc accttgcacg atctgcttga tgcccagttc cacaataatc caggtaaata 2134921 taacaaaggc agctaaaaat aaaatattca gccggatcgg aagcgacttc tttttctctt 2134981 tatgattttg cttttttggt ttatttctcc tcataacatc accttttcta tttacagaaa 2135041 gaaaagacac tcaagtaaga gtgccagttt tcattttaaa ggttttttcg acttttttct 2135101 acagataacc cctttttggc aaaaaaatta tctctcgcct tttaaaaggg tcggttctgt 2135161 tacccgtttt tggccgtctt cttccatggt ttcattttcc ccttctttct ccttaaaacg 2135221 aatatccttg acaaagtaat aaatcaaagg atgtcctata cccaatatcg caagtgacaa 2135281 aggaattccc acatcctctt tcagaagggc cacaatcagg agaaagcaca aaatggaaac 2135341 aattctgccg gcgttcaaga acatttctct aagcacgata tattcaattc ttgcttttct 2135401 ggcatgcctc gcgcgcccta tcacatcata tgtaagtgat acatatggca caagcaacag 2135461 aggatagccg atggcaataa aaacgccgta cgttaataat gtcgaaaagc tcatatggaa 2135521 cagaatcaaa aacagcgcgc catacaaaat aagtccgccc agcaaaatcg atttttttct 2135581 cgcctttttc ttaatcagcc tggatgcaaa gtagtaggca aagaaggaaa cagctgaatt 2135641 gacaagaccg aatgtaccga gagcaagctc gctgtttgtc tcaataaata caaacacact 2135701 gattaaaaag acaaaaatcc cttctctcaa accctgaaaa aaatgcgcat tcgtgattct 2135761 ccgccaattc atattgctat ggcgctctcc aaatactttg ctcagcataa aacggccctt 2135821 tgattctctc cgttttaaga aaaagctcat cacgacagcc agggcaaata aactgaggga 2135881 gagactgaaa atcactgtat aacccgtatt attttcaagc cttgagatca cgaatccggc 2135941 tacaatcggg ccgatcattc ctgcagagga agacagaatg cccataaacc cgttgaaaaa 2136001 gtctcgtgta tccggctctg ttatttcaaa ggtcagcacg ttaaacgcta gccaataaaa 2136061 gccatagcca actccgagca ccgcgccgat tagcacgagg cggctggccg ccgtttctcc 2136121 ggctaaaagc acacttaaat aaaaggcagc taaaaaaatg acgccgaacc ttaaaatgaa 2136181 taccctgtct atttttttgg ctaaccgtcc agccaaataa aaggttatcg gctgcattgt 2136241 cacaatggat aaattatata tcgccaaatc aataaatttc cctgactgct tccaaagata 2136301 cacattaaca aatgtattgg acagtgcaat tcccagcgag taaagcccgc caatggtcag 2136361 cagaaagagt aagcctttgt ttacgtctac atcgcctatc acttttttta gtttgctcat 2136421 tactgactcc cctttactat cccttagtct gtctcactca aaccgagata tgtaaaaaga 2136481 agacataaaa aaacaaggtc ccataatgag gaccttgttt gtgccattat tttgcttcgc 2136541 tgtatagacg agccacttcg tcccagttta caacattcca gaaagctgaa atgtaatcag 2136601 gacggcggtt ttgatagtta aggtagtaag catgctccca aacgtcaaga cctaagatag 2136661 gcgttttgcc ttctgaaagc ggagaatctt ggtttggcgt gcttgtgatt tcaagtttac 2136721 cgttgttcac aacaagccat gcccagccag aaccgaagcg tccagctgct gctgctgcga 2136781 attgctcttt gaatttgtca aagcttccaa atacactgtt aatctcttca gcaagcgcgc 2136841 cagtcggttc gcctccgccg tttggagata aaagtgtcca gaataatttg tggttcgcgt 2136901 gtccgccgcc gttgttgcgg actgcagtgc ggatgttttc aggaacagaa tcaagatctg 2136961 caacaagctc ttcaactgat ttgttggcaa gagcagtgtt tccttcaacc gctttgttta 2137021 aatttgtcac gtatgtgttg tggtgtttcg tatggtgaat agtcatagtt tccttgtcga 2137081 tatgcggttc taaagcatcg tacgcataag gtaattctgg aagttcgtaa gccatgataa 2137141 ttcctcctta gtatatatgt actgaaatgc cgcttcacag cgagcctttc ttcattcaat 2137201 gtaacaaaag aatgctttgt aatcaatgaa aaagctcacg atttggctca tttcagcgga 2137261 catatttcac tttaaccgat aatctgcccc attaaacctg ccgccagcat ttcttatagg 2137321 accgtccata aaaagtaacc gatcatcaaa agctgtatga tgccctttgc aataacccct 2137381 gttaaaaaac caatgagtga gccgaggcca attttaaacg ctgactttaa gtccttctga 2137441 tggacgataa gttctgcgca aacagccccg ataaacggcc ccaatatgat ccctgcaacc 2137501 ggaatgacaa aaggcccgat taataaaccg atcgtgcttc cccatatggc agctttgctt 2137561 cctccgaacc tttttactcc aagcagattc gacacgtaat ctgctgcgaa taatactgcg 2137621 gcaaaaactg cctcaacaag ccagaacata taagaatacg gactgaatga aaataaaaat 2137681 ccgtacaata caaatccggc aacaataaat actacgctag gaataacagg atacaccagc 2137741 ccgataaagg caatgataaa aaccgctgca atcaacagcc aatacaacat atccatagct 2137801 tccatcctcc cattttactc tgtcttcttc atgtcttcct tgtattcaca cgcatgcaac 2137861 gatacaataa gcaacatata ttagtttagc taggaagtga agatagtgaa tgtgtttcag 2137921 cttttcatta aaagtacata ctctccccgt gatattgcaa aaacaagatt tcaaggaatc 2137981 ggaaaagcga ttctttatgt atttttgctc tctgtcctgt ttgcaatccc taccgcttat 2138041 tatgtaagta cagggaccgt aaaatcaatg aacggcttta aaactgtttt aaacaaagat 2138101 ttccctgatt tcacaatttc aaacggcaaa cttcaaacgg atgagaaaaa agccacggaa 2138161 tctcaggcaa atggtttcgt tatcgtgttc gatccgacag actcctatgg cactgaacaa 2138221 attgaagcaa agcaaaacgc aatcggcatc cttcagaaca aatttgtttt ggccattgac 2138281 ggacaagccc aagaaatgtc ttactcaatg atgccgtcag agttacagaa aaaagatgtc 2138341 attgcaggtt taaaccaaaa taaagcgatg attgtaactg ttctctcagc tcttattttt 2138401 ctcgtaacag cagcgggaaa atttattgaa gtatcgtttt tagcgcttat cgggttaatc 2138461 attaagaatt cgcagaaaaa acatttatcc tatcatcagc tctggaagct ttctgcttat 2138521 tccatcacac tttcaactgt attctttaca atcatgcggg cactagaagc aaccgtacca 2138581 agtgaatttt tgctgaactg gtttgtcaat tttgtcatcc tgtttctcgt tttaaaagag 2138641 attccgtcca aaaaagtaat taataaaagt taaattatat ttatttttat cctttaagta 2138701 gagagtgtga aagcatttgc attaactttt tacttaaggg atatttaata aaatgtatag 2138761 agcttaaaca gatacattta taaaaaaagc tctacaatta ctcaagaaca agctctggac 2138821 aataatatca gaagtagtaa gatgtaacat gaaagaagtt cttaacagca tttgacatat 2138881 gtttttaaca aaataagaat aatgttaaat tttaactaat agactagtta aaatcatatg 2138941 gcaaaatatt ttgcatcctt tcacaacata tttacataag atagttgcta tttaaaaagc 2139001 caggtaccaa tagggcacct agctttcaga attaaatcat caacaagtta gaattatctt 2139061 ctttccttct attctcatta ttgaactgtt atcttttttg tgggtttatg tatacaaatg 2139121 cagctccctt agctttcccc ttatatactg ataaacctac tgcccaaggt gttcctgtcg 2139181 gttttggtaa tttactgaag taaaactttt tggttggagt tctacttgaa aagtaccctg 2139241 aatattgcgg gccaatgtcc ccaccctcaa ctatagatac accaaagctc ttataattta 2139301 gtttaccgca ttttccattt gtttcggcgt aagcatcaat agatgttgca ctcttagtat 2139361 atgtataagc atctgtaata actcttattt tacaaccaga aataccactt accggttgcc 2139421 aaccactgct tgcagcctct gctttttctt taggtgcaac taccaaagtt aacattagta 2139481 gcaaaattaa aaacacagaa aattttcctt gcttcatttt gtagatcctc ctttaaacta 2139541 ttacataatt atcctaacag atccattgtt cattgtaaat aatggaatac gagttttata 2139601 ttataaaagc ctctttttga tctaattttg cactattttc tattttctat ctgaagttaa 2139661 tgtttagtcg aagaaatcct gtcaaaaaag cgcctgtata aaaaccgagc attcgcagtc 2139721 tcttttcttt tgtcatgaat cgaaatggac aagcatacta tggtataaaa tttcgtatgc 2139781 gggaggaaaa gcgatgaagc gtctcacctt agtatgcagc attgttttta tactttttat 2139841 tcttttttat gaccttaaaa ttggaaccat acccattcag gacctccctg tctatgaagc 2139901 atcagcaaaa acggctgtac aagaaccggc ttataaaacg gtgaaggtaa agccgggtga 2139961 tacggttatg tcgatagtcg gatcagcagg ttctccggat gacattgtaa aggattttga 2140021 agcactgaat ccaaatgtga aagctaacgc cattcaagcc ggaacagcgt ataaattccc 2140081 ggtctaccct taatttaacg ttaatttctt gtcagttcgg cgaagacact gttacaatgt 2140141 aatttgtaaa ataaattcac ataaaccata ctagaattgt tatatctaga agcggcaact 2140201 acaattaagg agcgattgca agtgagtgaa atcacacatc gtacaaaaac gcgtcccgtc 2140261 aaagtgggac ctttaacaat aggcggcaac aatgaagttg tcatccaaag catgacaaca 2140321 acaaaaacac atgatgtaga agcaacggtt gcggaaatta accgtttggc tgaagccgga 2140381 tgccaaatcg ttcgggtagc atgtccggat gaacgggcgg caaacgccat tgcggatatt 2140441 aaaaagcgca tttccattcc tctcgttgtt gacatacatt tcgattataa acttgcgttg 2140501 aaagccattg aaggcggcgc agataaaatc cgaatcaacc ccggcaatat cggccggcgc 2140561 gaaaaagttg aagcggttgt taaagcggcc aaagacaaag gcattccgat cagaatcgga 2140621 gtaaacgccg gttcattgga aaaacggatt ttagaaaaat acggttatcc gactgccgat 2140681 ggaatggtag aaagcgcact tcatcacatt aaaattcttg aggatcttga ttttcacgat 2140741 attattgtca gcatgaaggc ctctgacgtg aaccttgcaa tcgaggctta tgaaaaagca 2140801 gcgaaagcgt ttgactaccc gcttcacctc gggatcaccg agtcaggaac actgtttgcc 2140861 ggcacagtaa agagcgcagc aggactcggc gccattttaa gcaaaggcat cgggaacacc 2140921 atgcgcattt cactaagcgc agaccctgta gaagaggtaa aagtagcaag ggagcttctg 2140981 aaatctttcg gcttagcctc caatgctgcc acgctcatct catgcccgac ttgcggccgt 2141041 attgagattg atctaatcag cattgccaat gaagtggaag agtatatttc taagataaaa 2141101 gcgccgatta aagttgctgt tctcggctgc gctgtaaacg gacctggtga agcgagagaa 2141161 gctgatatcg gaatcgccgg cgcacgcggt gaagggctgc tgttccggaa agggaaaatt 2141221 gtccgtaagg ttccagagga aacgatggta gaagaactca aaaaagaaat tgacattctt 2141281 gctgaggaac actacgcaaa acttgaagct gaaaaagcaa aattaaaaga agaaacacaa 2141341 aaagcttgac gggaacccgt caagcttttt tgtgttagaa aaatggaata ataaatattc 2141401 caagcactaa tgaaacgaca ccgataccca ttgcccaggc tccaaggcct tgagcacctc 2141461 ttcttcttgc gatatagccg acaataatac cagcagctcc caataaaaca ggcagtacaa 2141521 acaatgaaat gatggacaag gctaaagcga tgtaccctat tccccgtcct tcattgacat 2141581 tgccgccgct gcgatcattg tcttggtcat tgctgcggtc agcagcacga taaggctctg 2141641 cgatttcagc agctgtttcc tcaaaaaaac cgtcattgtc gcgggtaata tttgtccctt 2141701 cagatccatg atcaacatag taactgttgt tatcacgctt ttcgtaatcg tttgccacct 2141761 tcaattcccc cttctgtttt attaaaggag cttttatagt ttgatccatt ttgcctgatt 2141821 catgtttgct aaacttttct gttaatgtca attgtttatg ttacacttga agggatgaaa 2141881 ctgaaggagt gtgggcatgt tacgcttagg aatagatatt gacggcacaa tcacggctca 2141941 ggatacattc gtcccttatt tgaaccgttc gtttaatctt tccatttcat taaacgatat 2142001 gacggattat gatttaacaa agctgttaaa cattacccag gaagaatttt gggattggat 2142061 gaatcaaaat gaagcgatca tatataagga agcattgctt gcacagcatg cgaaacagtc 2142121 tctcgatctt ctcaaagagg agcacaagct tatttatatt acagcgagac ggactcattt 2142181 aactgatatt acttatgaat ggtttgacag acaaaacatt cattatgacc acatcgaact 2142241 tgttgggggt catcacaaag ttgaagcggt caagaatcat aacatcgacc tgttttttga 2142301 ggatcatcac gggaacgcca tgatgattgc gaaagaagcc gggataccgg tgattttgtt 2142361 caattcccct tataatcagc ttccgattga ttcaaacatc atcagagtaa acaactggct 2142421 agaagccgtt caatggatga acaacaacaa gcatcactta atacgcgtca ataactgaaa 2142481 aaggagccca aaccgggccc ctttttcata tatacgcatt ttacgcagta gtgttttctt 2142541 ggttttccgc tgtacaatca gggcatgtgc cataaatctc aaatttatgc ccgctgacct 2142601 gatagccatc caaatcatca caaagcttgt ccatcggaca tgattcaatt tcctttgttt 2142661 tgccgcaggc aagacaaata aaatgatggt ggtgatgggt gaatgaacac ttaaatcgga 2142721 agagcttttc accggacagc tcagttgttt ccaaaatccc aagttcttca tataaagaaa 2142781 gatttctgta gattgtatca aagcttaagc ctggataatc atcattcagt gcagacagta 2142841 cgtttttagc ggtaagatat ctgtctgaat cagcaaaaag ctgcagcata tcctcccgtt 2142901 tgtttgtata tttatatccg ttttctttta ataggttcag cgcttcttgg acgttcatga 2142961 agggtccccc ttttcgcttt gcttaagaac gtatcacatg tatgaaaaag aaaatggcag 2143021 ctgtctgtcc agcaagccat tttctttact gcagataaaa ttatacccat aaaatgaata 2143081 aaagtaaatg aaagcctagt ggattgcgtt tttgaatttt ccgcctctcg tttcatgagt 2143141 attcataatt gttatgaatg cattttgatc aacttcaaac acgatcgatt tgagctttgt 2143201 cacttccagc cttgtgacaa ccgcgtaaat tacgtctttt tcttcgtccg tatacccgcc 2143261 tttccccttc agcttcgttg tgccccgacc gagacggtgc aaaatcgcgt cggaaatctc 2143321 atcatactgc tcagacacaa taatgacagc ttttgtttca tcaagccctt ggatcacggc 2143381 atcaatcgtt ttcatcgcaa tataataagt catgaatgag tacatcgctt gctcaggacc 2143441 gaacacaaaa actgcccaaa tgaaaatgaa cacattgatg aacataacga actcacctac 2143501 agaaaacggg agttttttgg tcagcaaaat accgagaatt tctgtaccat ccattgaacc 2143561 tccatttcga ataacaagcc cgacgccaaa gccgagtaaa agacctccga acacagtagc 2143621 caaaataggc tgggttgtaa tggcttctac atggtgaagt gaggattcaa taacggcaag 2143681 cccgacaatc cctataaacg tagagactag aaaggtctta ccgatatatt tatatccgaa 2143741 gatcataaaa ggaatattta atatgacaac gaaaaaagcg aaattcagaa aggggtttga 2143801 cataaagagg tggtctaaaa taagagatac accgataatc ccgccatcaa taaaatcatt 2143861 ggggattaaa aataattcaa tacttacagc cgcagatgca gctcctacca gaatcataaa 2143921 gaccctgaaa ataaaatggg taaatgtttc tttcttatgt tgttttgttg gggtcataaa 2143981 atctcctttc ctgcaataac tattttaaat acattataaa tctattttac cattaaacac 2144041 tgacacattt tactgatttg cccatacatt aagtctggag gtggaatgac cgatgatttt 2144101 atttcaaaga attattttgc agcggcttaa tcaggctact gctgatgatt tgctgaagta 2144161 ctcaaaacaa tacggaatca gcttaacaag atcgcaggcc gttgaagtag cgaacctgtt 2144221 atacgggaaa aatgtaaaca tctttaatga gagtgaacga atgcggctgc tgaaacaagt 2144281 agagacgatt acatcgaaag aaacagctca aacagttaat gaactattca aacaatttac 2144341 aagctaaaaa atgggggtgt tatcccccat tttttattgc tgtaaaatct tttcaagcaa 2144401 tgtatcatca aattgttttt ctttcagcat ttcaatctca aaacggtatg gcggtttttt 2144461 gttcttttta tcttcaccga cgtatggtgt ttcaagaatt tttggaatgt cttttaactg 2144521 ctcatggtga acaacatatt gcagtgcgtc aaaacctatt tcaccaaagc caatattttc 2144581 atggcggtct tttctcgcac ctttgacatt tttgctgtca ttgatatgaa gcactttaat 2144641 acggtcaatg ccaatgattt tatcgaactc atttagcact ccgtcaaagt cttcgacaat 2144701 gttatacccg gcatcatgtg tatggcacgt gtcaaagcac actgacagct gctcattgtg 2144761 tgtaacgcct tcgataatct gcgcaagctc ctcaaagctt ctgccgcatt ctgatccttt 2144821 tccagccatt gtttctaatg caatctggac attttgattc ggatcaatca cttcatttaa 2144881 gccttcaata atttttttga tgccggcttc agctcctgcc cctacgtgag cgccaggatg 2144941 aaggacaatt tgcttcgctc cgatggccgc tgtccgttca atttctgaac gaagaaaatc 2145001 aacacccagc tcaaaagtgg acggatttgt cgtgttgcca atattaataa tataaggcgc 2145061 gtgtacgata atctcgtcaa tgccgttttc ttgcatatgt gcccggcctg cttctatatt 2145121 taagtcttca attttctttc ggcgcgtatt ttgcggtgcg cctgtataga tcataaacgt 2145181 attcgcccca taagagactg cttcctggct tgcagccaga agcatatgtt ttccgctcat 2145241 agagacgtgt gagcctattc tcagcaacag gttcccctac tttcttttct tagattggtt 2145301 tcttctctgt tttttcttga ttttctccat ctcatagctc attttctttt tatacccagg 2145361 cttaaccttc ttcggctttt tcacgagacg atgagcaatt tcatccgctt cattcggcgt 2145421 ttttttacgt tttttgcggc gctgacggtc atcgcctttt ttccattcgc ccttttcaag 2145481 ctctaagtac tcaaattcga tgcccatttt ttcaagtctt actaatgcat cctcatcagt 2145541 aagctcataa atggtcatcg cttgtcctga tgagccggca cgagccgttc tgcccacacg 2145601 gtgaacatag aaatcgagat catccggcag ctcatagttg ataacatggc tgacaccttt 2145661 aatatcaata cctcttgcgg caaggtcagt tgcaatgata tatgtgaatt ccaaatcatt 2145721 gatctgcttc atgacttttt tccgctcacg tggtgttaat ccgccgtgca gcaagccgat 2145781 tttcatgcct ttgccagtca gatactgggc aatatggtca gccgtatttt tcgtgttggc 2145841 aaacacaatc cccaggtatg gattcagatg cgacatgatg tcaaaaagga gcttgtcctt 2145901 gtcacgatgt ttcgaaggaa tgaggatatg ctcgattttc gcagcagtca cctgttttgg 2145961 ctccacatgg gcgtatttcg gattttccat gtatttcttc aagaatggtt tcagcttttc 2146021 cggtatggtc gctgagaaca caagcatttg cagatcctca ggcatgcggg aaccgatgta 2146081 atctacatct gcaaggaatc ccatgtccag cattaaatcc gcttcatcaa taacaagaga 2146141 ttccgcttta tgaacactta acgcctgttc tttgattaag tcagcaatcc gtccaggtgt 2146201 accgacaaca agatgcggct gtattttcaa tttatcaatt gatttttgtt tatcagtgcc 2146261 tccgataaaa catttcgagc gaatctgact tccttcttca ccctgcgtga ttttaagcgc 2146321 ttcctgataa atctggttgg caagctctct tgtcggagcc gtaatgacta cctgaacgac 2146381 atccttagca ggatcgattt tgtttaataa aggcagtaaa taagcgtgag tctttccagt 2146441 acccgtctga gactggccga tgacgctttc tttttttaac actgcaggaa tcagcctttt 2146501 ctggatatca gtcggttcgt aaaaaccaag gcgatgtact gcatctataa taaatggttt 2146561 caattcataa agttcaaatt tcgtttcttt catttttccc agctccttaa agcggcacat 2146621 tatgtgtcca tcatcacatt atacccgatt ttgcttaaaa acaccacgtt tgcaaggcgt 2146681 ttgttttatt cagttatgta aagcaaatac cgcagcccat gcatattcta atagcagaga 2146741 gagctgaaag gaggtacaag tatgttttca ccgcagcagc caatgagaaa ttacccacag 2146801 cccggaccgc cccgccccat gccaaatcag cgaatgatgg gcagaagacc gcctaatatg 2146861 cgaggacctt catttggagc acagcagcaa ggttttcagc aagccggaca atttcttcct 2146921 caggcaaatg ccggagcgag aaatggtgca ggtgcaggcg gaggcttaaa aggaatgctg 2146981 tcaaggttcc tccccggcgg aggaggcgct ggcagcgccg gggttcccgg aattccagga 2147041 gcaggtgcag cagcgagcgg aggtgctggc ctgcaaggca ttcaaaatat tgccaatcct 2147101 gcatcattat ccagtatgct tggaaatgtg caaaaagtac tcggcatggc gcagcaagtc 2147161 acccctatga tccagcagta cggcccatta gtccgcaatc tgccagcaat gatgaagctg 2147221 tacagccaat taagtaaaag tgatgatact gagacagagg ccaatgagga aagtgaaaaa 2147281 caatccgttt cagaagaatc atcagaaaaa gaaaaagaga ctgaaacaaa aacctcagat 2147341 gggaacaaaa aatcaaaacc aaaaagttct tctctcccaa agaaatctaa aacaactgac 2147401 aataaagaac aagaattaaa aacatctgcc ccgaagaaaa aggaagctgc ctctcctgct 2147461 ccgaaaagaa catcaggcag ttcaaaaccg agattatata tttaacattc tttgatatct 2147521 taagtgagat tggctataat gagatcagaa gaatgcaaga atagagccgt ttgattacgg 2147581 ctttttatat tgcctttact cacttcagta ttggaggaca accgaaaatg gacgtaatta 2147641 aaatttcacc gcgcggctat tgctatggtg ttgttgatgc tatggtcatt gccaaaaatg 2147701 cgtcgctaga taaaagcttg ccaagaccca tctatatact cgggatgatt gttcataata 2147761 aacacgtcac tgatgcgttt gaagaggaag ggatttttac attggacggc tctaaccgtc 2147821 tggacatctt aaagcaggtt gacaaaggaa ctgtcatttt cactgcgcac ggtgtttctc 2147881 ccgaagtcag aagaatcgca gaagaaaaag ggttagtcgc aattgatgct acatgtccgg 2147941 atgtgacaaa aactcataat ctaatcttag agatgaaaga aaaaggatat cacgtgatct 2148001 atatcggcaa aaaagggcat ccagagcctg agggagccgt tggcgtagcg ccggagatcg 2148061 ttcacttagt tgaaacagaa gaagatgtaa agaaccttga tatccaatct gagaagttaa 2148121 tcgtgacgaa tcaaacaaca atgtctcaat gggatgttca cgacattatg gagcttgtca 2148181 aagaaaaata tcctcatgtc gaatatcacc aagagatttg cctcgctact caagtgcggc 2148241 aggaagctgt atcagagcag gcaaaaaaag cggacttaac aatcgttgtc ggagacccga 2148301 aaagcaacaa ttcaaatagg cttgctcaag tgtcagagga aatagccggg acaaaagcat 2148361 accggatcgg cgacttaagc gaattgaagc tcgaatggct gaaaggcgtt aataccgttg 2148421 cagttacagc gggagcttca acaccgacgc cgatcacaaa agaagtcatt cgctttttag 2148481 agcagtttga tcacgaagat ccatcaactt ggacaactga acataatata ccgctcaaaa 2148541 aaatacttcc aaaagtaaaa gcaaaaaact gaggctgtaa aagcctcagt ttttttatag 2148601 aaatgtaaat ggatttgtat ctgtttcaga aacaaagata ttcacgccaa actttttatc 2148661 attacacatt gatgtaagtt ttctcgtgac gccttctttc atgatttttt ccgcgtaatg 2148721 gcccggatca accacattta ggccaagcat catcgcatca tgggccacat ggaagtataa 2148781 atctcctgtg acgtaaacat cggctccctt tcgttttgca tgatgaatat acttgtttcc 2148841 atctccgcca agaacagcta cttttttcac catgctgtca gcatccccaa ccattctgac 2148901 accattgacg tcaagcttgt ctttcacaaa taaagcgaat tccttgagcg tcatctcatt 2148961 tttaagggtt ccgacacggc cgagcccttt ttcggcggga gtctgttcga caggatagat 2149021 atcgtaagcg acttcttcat atggatggct ttttatcatt gcattgataa cagccttttc 2149081 gacgctttta ggaaatacag tctcaagcct tacttcatga acaagctcaa gctctcccac 2149141 ttcaccgata aaaggcttag ctccgtccaa tggcttaaag ctgccgattc cttcagatga 2149201 aaacgcgcaa tggctgtatt caccgatatg gccggccccc gcatttccga gcgcggctct 2149261 gacctgctct tcatattcct tcggcacgta aactgccagc tttttcagag gatccgtata 2149321 agtaggtgcc agcacttccg tctcactcag ctctaatgct tcagcaagca aatcattcac 2149381 accgccgtcc gcaacgtcta aatttgtatg agctgcataa acagcaatat catgcttcaa 2149441 acacttttca attaaccttc cggcaggctg atctgttgaa atatgcttta gcgaccggaa 2149501 aattggtgga tggtgtgcaa taatcaagtc aacctctttt tcaatcgctt catcgataac 2149561 gctctctaac acatcaagtg taaccatcac atttttaatt ggtttgttta aggtgccgat 2149621 ttgcaggccg attttatctc cttcaaccgc ataggctttc ggggaaaatt gttcaaacag 2149681 ctggatgatc tgctgcccat ttacactttt agccatgatc gattacctcc tttaacagct 2149741 ccattcgatc ggcgagctcc tttaattttt gtttgttttg ctctgtatcc gccgcttggc 2149801 tgatctgttc ataaatgctt tgagtgtgct gaagctcttg tgtccacttt ttcaaaaaga 2149861 cagcattttt ttcttttgcc aagaaagggc caacgagcat cccggctgat aaagaaatac 2149921 cgtcataagc cgcatccctg tctcccgctt ctgccaccag cacctcatag cactttccgt 2149981 cctcttcaag gattacctca tctatcagcg catatctttc tttataaagc cactccctga 2150041 tatgaacagc atgaatattc ggctgtaaaa tgagccgttc cttccccgtt aatttgtctt 2150101 tgcccgcttc taaaatgtga gcgatcaaag ccccgcccat tccggcaatc gtaatggcat 2150161 cagcttcacc ttttttaatc acttccagtc cgtctccctg ccttacagaa atgtgcgagt 2150221 ttaagcctga tttttcaacc tgccgctttg cagacaaaaa tgggccgtct gttatttctc 2150281 cggcaatcgc cccgctggct ttatgattca gcaccgcata acaaggaagg taggcgtggt 2150341 cagagccgat atcggccatc accgctccat tcggtatgta ctccgctact gtttgcaatc 2150401 gtttagataa ttttaattcg ttcacttgtc atcacaactt ttctcaatca ttttttcctt 2150461 tactatcata taaaaaatca gcccggaatc caagctgaag caaatgattt tgaaattatt 2150521 tcttttgatg cgggtctgca cgcagcagtc aaaaataaaa ggctgtcgag aacatctcgg 2150581 cggcctgtga atgtataaag agaaaaatag ttcttttatt taatttttga cacccactct 2150641 gccatatcat ccagcttatc ggccggaaca agaccggaag gcattccatt accgcctttt 2150701 tcgatctttg ttttaatttc agcgacatct ttcttatccc ctacaccttt taagctagga 2150761 cccgaaacac cttcataatt ttcaccgtgg catgcgatgc agtttgcctt gtaaatttct 2150821 tctggtgaag cgtttgcatc tttcttttca gcagatttgc tttctcctcc gctcgcaatc 2150881 tcccgagagt catcaagtcc ttttactgat aaaaagaaag ttagaccaat tcctaaaaca 2150941 gcgatcagca aaaatggaat aagcgggttc catttcattt cccttccccc tttttgatcc 2151001 ttccccctat gtaaacactt ctaattctaa cttattttta caaaaagtaa atggattgct 2151061 atacaaaagt tttttattca cactttatac aaaattgaat agaaacatgc ctaaatctct 2151121 aatatccttt ttattctatt gtataatgta ttgtatacgc ttacaataga aaatatggaa 2151181 ttagattttg aaatttttca ccacaatgtt catttgcaaa tgacatcatt tttcagtaaa 2151241 ataaaggcat attatccata tatcttttta aaaaaagaag aacggatctt caagacccgt 2151301 tccatcttat tcaaggaaat ctttcaaacg tttacttctg ctaggatgtc ttagtttccg 2151361 caacgctttg gcttcgattt gtcgaatacg ctctctcgtt actccaaata ctttgccgac 2151421 ctcttctaat gttcttgtac ggccgtcatc aagaccgaat cgaagacgca atacattttc 2151481 ttcacgatca gttaacgtat caagcacatc ttccagctgc tctttcaata gctcgtatgc 2151541 ggcgtggtca gaaggtgaag ttgcttcttg gtcttcaatg aaatcaccaa ggtgcgagtc 2151601 atcctcttca ccgatcggtg tttccagaga taccggctct tgagcaatct ttaagatttc 2151661 gcgtactttt tcaggcgtta aatccatatc ttccgcaatt tcttcaggtg ttggttctct 2151721 gcctaagtct tgcagtaatt gacgctgcac acggattaat ttattaatgg tttcaaccat 2151781 atgaacggga atccggatcg ttctcgcctg atcggcaatg gcgcgtgtaa tcgcctgtct 2151841 gatccaccac gtagcatacg tactgaattt ataacctttg cgataatcaa atttttcaac 2151901 ggctttcatc aggcccatgt ttccttcctg gatcagatca aggaacagca taccgcgtcc 2151961 gacataccgt tttgcgatac tgacaacaag ccgcaggttc gcttcagcca atctgcgttt 2152021 agattcttcg tcaccttctt caatcttttg agcgtaggcg atttcttctt ttgcagaaag 2152081 aaggttaacc cgaccgattt cctttaaata catacgaact gggtcattga ttttaacgcc 2152141 aggcggtaca cttaggtcat taaggtcaaa ttcttcttcg gctttggcaa gctgctgaat 2152201 attaggatct tctgtttctt cattctcact aattaattca acaccttgtt cacctaaaaa 2152261 ttcataatac tcatccattt ggtctgattc aatttcaaag ctggacatac gctcagcaat 2152321 ttcttcatat gtcaaaacgc cacgtttttt accagactct gttaattgct cttttacttg 2152381 gtcgaatgtt aattctgtct cgtgggtttg tttatcagcc attatggatc cctccttcca 2152441 aagcttgcaa cgaattctat aagcggtatg attcttattc ggtccattca ggcgttttct 2152501 atgtgaactg cctttaacaa tgtgcgaata atgaaatgac aattcatgat gaggttaagc 2152561 gatctatttg ctcctccgca aggaatcatt gccaataaat gctcctcatc agttctccag 2152621 ttattttaaa gatcggttca atgtaacgat ttcttgagcc aaagaagcag ctcttaaaaa 2152681 atctttttgc ctttctgctt cggctctttc cgcctctttt tcttttatca ttgaccaatt 2152741 tctttgattc aacacttttt ttacataatc tgataactcg gcttcgctaa gctcttgatt 2152801 aacctgaagc attaatatat cggacaagag ctggcttata tgatcatccg tcaccctggc 2152861 catcagatgc tgaggcgtca gctcggctcc ctcttcataa aaagcataaa gataagcggc 2152921 taatgcccgg tgctcatcaa tattaaattg aaaccctacc cggtcaatca cttttttgat 2152981 gacgctccga tctcgaagca tgtgagcgag taacagcctt tctgcatttt catacgccgg 2153041 acgcaaacgt ttttgccttg cttttgtcgt cagatgcgct cgccgcgttt tagtttcacc 2153101 gctattgtca gcaggtttgt tttgcttgct gaaaacagac agctgctcag ttaaagactc 2153161 ctgtgaaagc gaaaactctg aagcaagctg ctttacatag acttcctgct ctagagaccc 2153221 tgaaagcgtg ctgatttctt tcagtacgtc tttaatgtaa gctaggcggt cgccttcatc 2153281 ggacaggttc tttccttttc ggaaatattg cattttgaac gccattacgg tgacacttgc 2153341 gtcaataatg tcgtttttaa atttttcccc gccgaatttt ttgatgtaat catcagggtc 2153401 caatccgtca ggaatcattg caactctgac tttgcagcct tttttttgca gaagctccga 2153461 agcttttaag gtggcttcat aaccggcttt atcagagtca tagcaaagaa tgatttcttc 2153521 gacgtttctt ctcaggatct tgacatgatc atctgtaaga gacgttccca tcgtggctat 2153581 gctttccttt acatccgagc ttacggccga tatgacatca gcaaaccctt caaataagac 2153641 tgctctttcc tgctttctga tatgaaggcg ggccttataa aaattgtaaa gcagtttgct 2153701 tttatgaaag agcggggttt caggactgtt catatactta ggctgctggc tgccaagagc 2153761 cctgcctgag aaagcaacaa cagccccgtg atgatcatgg atcggaaaca tgacacggtt 2153821 tctgaagcgg tcgaaatatc cgcttccgtc ttcgcgtctg atcaggagac ccgctttttc 2153881 catttgcgcc tcactaaatc ccctctttac aaggaatttc gtgataaagt cccaagaatc 2153941 aagagcatag ccaatctgaa attcattaat cagctctttc gtaaagcccc tagaaagcag 2154001 ataatccagt gcctcttgac cttcttttgt atttattaac aaatgatggt aaaatttctt 2154061 caggagctca tgtgcctcag ccattttttg ttctccagaa gactctggcc gggctccgga 2154121 atggactgtt atatcatctg gaaaatcaat ttggtatttg tcagcaaggt gagaaaccga 2154181 ctcggcaaaa gaatagcctt ccatctgcct taaaaaagag aaaacattgc cgcccgctcc 2154241 gcagccaaag caatgaaaaa tctgtttgtc gggcgatacg gaaaacgaag gtgtgctttc 2154301 tccatgaaaa ggacagagtc caaagtagtt tcggccttgc ttctttaatt gaacataatc 2154361 acctatgact tcaacgatat ctgccgactt ttgcacctga tccacaattt catctggtat 2154421 ccgatttccc atcttataac actccgtcgt acattattcg atgctttagt gcaaaatccc 2154481 ttcatcgttc gacaggattt tttgcagcag tgtaataaat cgttctcgat cttctttatt 2154541 caatttttta ggccctttgg catatacgcc ttttcttctt tgtttgccgg aaaaatgacg 2154601 gccctctagg gcaaaatcaa tcgtgtcttc cttgtaaaga cgacctcttt ccgacataac 2154661 agagacattt ctgttcaaca gcagagatgc taatccgatg tcctgcgtca caacaatatc 2154721 tcccggtttc acgtgatttg cgatatataa atcagcagct tctttatgag gatcaacata 2154781 cttccatttt tcttcattgc ttctggaaag ctgataatgt tcaaatgaag cgacaaaaag 2154841 aacttgaact tcatactcgg atgctgtttg taaaatttca tcttttaccg gacaagcatc 2154901 agcatcgaca aaaatcgtct tttcttgttc attaagaaga gtaattctcc atccctccat 2154961 taaactcctg cataaaagca agcaaaatcg cacatccttt attattgtgg atgtatatga 2155021 atttgtcgaa aaatttccgg gagaaattct tgacatctta cccataatag tttattcgta 2155081 tcacacgatc cttaaaccta aaattaatca ttttatcaca attttttatt ataatacaaa 2155141 cttcacaaag atgctattgt ttttcattat tcccttttgg cacagccaaa aacccaggat 2155201 agagcgtcct gagttatatg ttttttgttt tgagatgatg gataatattt gctgtttcct 2155261 caaccgcttt atttgaaaca tcaacaacct ggcagccgat ccgatccaca atcttttcga 2155321 aatactcgag ttcctctttg attctgttga tatttgcata aatcgcttta tcattaagcc 2155381 cgagtgattt taaacgttct tttctgatat gattcagttt atcagggcta atctttaaac 2155441 cgatgcattt tttcggatca acgttaaaga gttcttccgg cggatcaacc tccggtacaa 2155501 tcggaacatt ggcaaccttc aggcgtttgt gtgcgagata ttgagacagc ggtgttttag 2155561 acgttcttga cacgccgatc aaaacgatat cagcttttaa aatccctctt ggatcacgtc 2155621 catcatcgta tttaactgca aactcgatgg cctccacttt tttgaaataa tcttcatcaa 2155681 gctggcgcac ccgccccggt tcgtatttcg ctgttaaacc gtaggctgtt tccattttat 2155741 caatcaacgg gccgataata tcataatata aaacatttgc tttttccgct tcggctatca 2155801 aatattctct gatttccggc accacgagtg taaaacagat aatgccgccg tctgcctttg 2155861 caagtgaaat cacttcattg atagtgccta tatcttcaac ataaggaatt cttcttacat 2155921 gagtatcatc cgccgatccg ttaaattggc tgagtgctgc ttttactacc aattcagccg 2155981 tttcaccgac ggaatccgat acaacataga tgatgcggtt attcatatta tccccccgtt 2156041 agtttgcaat cttataggat ttcattttca gataaactga caagtatttt ggtcatattt 2156101 gtttttgtca ctctgccgat cacttcaaag cctttatcgg tgtctttgat gacaggcagt 2156161 gcatcaattt gtttttctat taagtgcttt gcaatgtcca tcacataatc ctcgcgtctg 2156221 cacaccgtaa tgttcggcat ccttgtcatg atgatgtgaa cagggaccga tgtaagctcc 2156281 tgctggccaa tgctcgctct gagcaagtct tttcgtgaaa gcaccccgac taaaacagca 2156341 tcgcggtcca ccacaaacag agtacctaca tcttctaaaa acatggtgca aatcgcatcg 2156401 tacacagaaa cgttttcgtg aatcactacg gggatagatt gaaagtcttt cacctgaagc 2156461 tttttgagtt tatccgccaa aagctgtgtg ccggtttttc ccgtatagaa ataaccgact 2156521 ctcgggcgcg cctcgaggaa tcctgacatg gtgagtatgg ctaaatccgg gcgcaatgtc 2156581 gccctggtta ggttcagctt ttctgcaata tgctcccctg taatcggccc gttttctttt 2156641 acaatctgca aaatatgttc ttgccgttta tttagttcga tcgtactcac caccttttca 2156701 cttcatagct atgtaaagaa ataacaatcc atattataac gtaaatatct tgtaatcaaa 2156761 caaaaaactt ataaatgggg aaaagacgat taccgatcac acagcaaccg ccttttctct 2156821 ctttatttta caataagggc attcatattc gcaaaggact tgatctcatc cgccaagctt 2156881 accatttgcg ctaaacgatt tgcctttaat gactcattat ccgctataac cattgtatga 2156941 tcgaagtaag catcgatcgg ttcttttaag gctgcaagtg aagcaagcgc cgcctcataa 2157001 tcttttttgc tgaagttttc ctgcagattt tgcttcgctg tttggtaggc atcaaacagt 2157061 tttgcttcgt attcattttc aaacagatca ggctgaatgt ctccgcggac tccttttttg 2157121 ctgatagaga tcactcggcc taacgcttcg gctgtttcct taaagccagg tgcaccaagc 2157181 ttttgctcca gtacttgtgc tttatgcagc gcagagtacg gctcaagctc agagctttcc 2157241 agcacggcgt caatgacatc atgtctgatt tgttcagcat tcaagacata tttcaagcgc 2157301 tgagtgaaga aatccagcag ttcattttct ttatcggttt gaacgaaagt aagcagctct 2157361 tcaaatgaaa ttccccagtt gcggtcaaga agaatcgcaa caataccgct tgcttggcgg 2157421 cgcagtccgt aagggtcctg ggaaccggtc ggaattacgc cgatagagaa gaatgaagcg 2157481 attgtgtcaa gcttatccgc cattgctaca acagctccgg tgaaagtaga aggcgtttct 2157541 ccgcccgctg atctaggcat ataatgttca ttaactgccg cagccacagc ttcatcttcg 2157601 ccaagcattc tcgcatactt ttcgcccata attccttgaa gttcagggaa ttcatatatc 2157661 atatgcgtca caaggtcgaa tttagaaatt tcagcagccc gcttcacatg ttttaatgta 2157721 tcttcatcag cctgaagacg aacggcaagt ttctctgcga ttgatgtgac tctcctaacc 2157781 ttatcagcaa gagaaccaag ctcttcatgg aaaacgatat tttcaagctt cttcacattt 2157841 gcatcaatgt ttagtttctg atcttctttg tagaagaatg aagcatcaga taaacgtgcg 2157901 cgcagcactt tttcattgcc tcgggccaca ttttcaatcg cgtggctgtt gccgtttcgg 2157961 actgtgataa agtgaggcag caggtcaccg tttttgtctt tgacagggaa gtagcgctga 2158021 tgctctttca ttgtcgtgac aagcacttct tcaggaattg acagaaactc ggattcaaat 2158081 gaaccgtaaa gagctgtcgg gtattctact aaatgattca cttcatcaag aaggtcttcg 2158141 tcaactggaa tgctccaatt gttttcagca gccattgttt ccagctgaga ttgaatcatt 2158201 tgctttcgga cgctaggatc agcaataaca tgctgtcctt tgagctgctc ttcataagct 2158261 gaaggtgatt caattgacac ttcatgtccg aggaaacggt gtccctgtgt tgtccgtcca 2158321 gactcaacgt ttgtgatcga aaatggaatg acatcctgtc caaataatgc gacaatccat 2158381 ttgatcggtc ggatataacg caaatcttca tttccccagc gcatgttttt cgggaaatgc 2158441 aagcttgtaa ttaaaccgct caattctggc agaagcgact tcgtttcttg gccggcttgg 2158501 aatttttgca cgaatacata ctctatgcct tttacttctt tgatgtacag gtcttccaca 2158561 tttgcgcctt ggccttttga aaagccgatt gccgcttttg tccagttccc gtccgcatca 2158621 agggcaattt ttttcgcagg cccttttgct tcttctttta tatcatcctg cttttctgcg 2158681 acatccttaa cgaacacagc aagacgtctc ggtgtattga agagtttcac ttcaccgtga 2158741 gtaatatttt tttctttaag ccagcctgtc agcttgtcgc caagctgaac catgctttca 2158801 ttcaaaaagc gcgccggcat ttcctctaat ccgatctcta aaagtaaatc ctgtttactc 2158861 atgagaagaa ccctcccctt taagcattgg gaaccctagt ttttctcgtt cctcatagta 2158921 ggtttttgct acttttctag ctaaattccg cactcttgcg atatagcccg tccgctcggt 2158981 aacagagatc gcacctttgg catcaagcag gttgaaagtg tgcgagcatt tcagcacata 2159041 gtcatatgct ggatgaacaa gtccgttgtc catttgcttg atcgcttctt tttcatatgt 2159101 gctgaacaat tggaacagca tatcgacgtc tgatgtttca aacgtataaa cagaatgctc 2159161 atattcagcc atcatgaata aatcttttac tgtaaaccct gacgtccatt ccaagtcaaa 2159221 cacgttttct ttatcctgga tataagacgc gagacgctca attccatacg taatctctac 2159281 agaaacgggt ttacactcta atcccccgac ctgctggaaa tacgtaaatt gtgttatttc 2159341 cattccgtca agccaaactt cccagcctag acccgcgcag cctaaagacg gattctccca 2159401 gttgtcttca acaaagcgaa tatcgtgctc aagcggatca attccaagag cacgcaagga 2159461 atccaaatac agctcttgaa tgttatcagg tgacggttta ataatgacct ggaactgatg 2159521 atgctgatac agtctgttcg ggttctcccc gtagcggccg tctgccggac gtctggaagg 2159581 ctctacataa gccactttcc acggctcagg accgatactg cgcaaaaatg tatacgggct 2159641 catcgtgccg gctccttttt ctacatcgta agcctgcata agcacacagc cctgactgga 2159701 ccaatgcttt tgcaaggtta gaatcatgtc ttgaatattc atttcaagca cctccacttt 2159761 tctttcataa gttgactgcg gcagcaacca aaaaactccc gtctctatgc ttgccagccg 2159821 caaacatagg gacgagagtt ctcccgcggt tccaccctag ttgctgagaa caaaatccca 2159881 gcctcttttt taaaattgct caagaatgcc tttcgttgcg tgctcatcct tagcttacac 2159941 cgccctaagg tcgctttcat gaggtaaacg caagtacttc tttctctcac tgcaacatat 2160001 tttataataa atgatcatat aaaaagatgg accaaatgtc aacttttgtt ttcacccata 2160061 agatgtttca tgctttccat ttgatctaaa aagcgctttg attttaaata caatcccgaa 2160121 tattcttcgt aatataaatc aatcacttgc tttaattcag cttttgtttc ctcttttaag 2160181 gacacattgc cgagtctcga cagatcaaaa tagtaaaaga gccttaacag ccttgccgtt 2160241 tgcggtttaa tcggtatcct gtaaggatct ttttcaaaac agcggtggca tataaaacca 2160301 ttatcacgaa cagagaaatg aaaggttccg tcttggcttt tacaatgtac acaatgattc 2160361 agctcaggat acaggcccat gacaccgagc atcttcattt gaacaatgaa ggtgataaca 2160421 tccggatctg ttccttcatt caactgtttt aatgattcta atatgaattc aaataaataa 2160481 ggatttggct ttttttcttc tgtgcctctg tcgactaact cagcaacata ggcagcatat 2160541 gctgttaaaa acaagtcttc cctgatgcct ctcatgctga ggatcatttc cccctgctga 2160601 agcgttccga ggcccgatgt tttttgcatt aagaaagaac catacaaaaa gggctggctg 2160661 actgctgata aacggctgtt cggttttttg gcgcctcgtg ccataacacc tatttttccg 2160721 tgttctcttg tcagtaatgt tacgatttta ttcgtctctc cgtaatcatt tgtgcgaaga 2160781 acgatccctt cacattttgt cagcatttcc gcaccttcct caagcaggag cggccaagag 2160841 gtttataaaa ttggataatc aaatcgggct agctcatctt ctagttcttc gggtctttcc 2160901 atgttctctt tttccagttc tttaaaaaga agatacgtat caacatttcc tgtttgagaa 2160961 aatacgttcc aggtaaaatt caacacaaga aacccacctt tctgtagtta aactagctta 2161021 cctaaactcc aaattcttac ctttatcttg accagatgtc ctccatttca tgttaaacaa 2161081 aatttgctaa tgtatccctg ttcctgtgag ataatgacac acacgggaag agattaatat 2161141 tcgtcctctt taaagccaaa atcgcgaagc tgggacattt tattacgcca gtctttctgc 2161201 actttcaccc acaattcaag gtagacacgg gagcccaaca gtgcttcaat atccgctctc 2161261 gctctttttc caacctcttt tagaaggctt ccttttttac cgatcacgat gcctttctgg 2161321 gaatcccgct cgaccacaat cgttgccgct acgtgcacag aaccgttgtc ctgccctttg 2161381 atggattcga tggccaccgc aatgctgtgc gggatttctt ctctcgtcaa atgcagcacc 2161441 ttttccctga ttaattcaga aatgataaat cgttcagggt ggtcagttac ctggtcactc 2161501 ggatagaatt gcggcccttc cggcaaatac gcttcgatct gcgcgagcaa ggtttcgatg 2161561 ttatttcctt ctaaagcaga aatcggaaca atttccttaa aaggataacg tttgcggtat 2161621 tcgtcaatta gcagaagcaa ttggtcggga tgaattttat caattttgtt tacgattaag 2161681 aatacaggcg tagacatcgt ctgcaatttc tcaatgatga attcgtcgcc cttcccgtag 2161741 ccttcctcag cattgatcat aaacaagatc aaatcgactt cttttaatgt attttgcgcc 2161801 actttcatca taaagtcccc aagtttatgc ttaggtttat gaatccctgg tgtgtcaata 2161861 aaaatggttt gtgatgtgcc tgtcgtcagt actccttgca ccttgtttct cgtcgtttgg 2161921 ggcttatcgc tcatgatcgc gattttttgt ccaatgactc tgttcaaaaa tgtagatttt 2161981 cctacgtttg gtcttccaat aatggataca aatcctgatt taaagctttc gttcgtcatg 2162041 taaatcctcc gatgaaaatg cgcctggcaa taattcttcc acagtcattt cttttatttg 2162101 tccttgtaaa ttagtcagta cgacaataac gtcttttgtg caaagctcag aaatcacctg 2162161 tcggcaggct ccgcacggag atactggtcc aggggtgtca gccgcaacgg ccagcatctg 2162221 aaactctgta tccccttcag aaacagcttt aaataaagcg gtacgctcgg cgcaattgca 2162281 catgctgtat gccgcgttct caatattgca gcctctgtac acttttccat ccttggtaag 2162341 aagagcggct cctacttgga atttggaata cggcgcatat gccatatcac gcgcttttaa 2162401 agcttctgtt attaattctt gtctgttcat gtgtacattc ctctcttacc tataatggta 2162461 ccgctatcac tttatatttt acataatcgc gcgctttttt tcacgcccat ttctaaaaat 2162521 gtaaaataaa tgtaagaatt ttcagccatt acagctttgg caaaaaaata agtaaaccaa 2162581 tgatacacga aatcacggca aaaacgcaaa cagccccggc ggcagcgtcc ttggccgctt 2162641 tagcaagagg gtgatgtttg tcagttatta aatcaaccgt atgttcaatg gctgtattta 2162701 aaagttcaag cgaaaacata ccacctatca aaaggaatat aatcatccac tcaataatgc 2162761 tgagctctac aaggaagccg caaatgagaa cagcgcaggc ggctgcggca tgaaattgga 2162821 aattccgctc cgtccgcgct gtttcccata tgccccggcc tgcatgcacg aagcttttga 2162881 agaatcgatt cagctcattt ctatgatctt ttgagtccat aagcgtccag caattccttt 2162941 tgcttagtaa acatctcctc ttcttcctct ttcgtcatat ggtcatatcc taaaaggtgc 2163001 agaaatccgt gtacagctag aaatccgagc tctcttttaa aagaatgatt atactcctct 2163061 gcctgctctc ttgtgcgatc ggcactgatg ataatatcac ctaaaaccgg aggcatttcg 2163121 gcgcccacga tttcgatctc gccttctccc tcttcttcaa gagcaaatga gatgacatct 2163181 gtcggagcat cctttccccg gtattctttg ttaatctgat gtatgtcatc attggaaaca 2163241 atcgtgacag aaacttcagc ctgatcctga acgccttcac gctcagcggc aaattgaagc 2163301 agattttcta cttctttgag catctcttct gagacgcttc ccgtttcatc aacgatatca 2163361 atcagtaaac tcatctattt caccttctta gtagcctccg gatattcaat ccgggagtgg 2163421 aaaattcctt ttaatgttgc acagagcgtt tttgcgattg tatccagctc tttaaatgtc 2163481 aaatcgcatt cactgaactg tccgtcctga agcttatcgg atataatacc ccggacaagc 2163541 ttttcaattc gttcaggatt tggattgtgc atggatctga cggccgcttc aacactgtcg 2163601 gccactgata taattgcggc ttcctttgac tgcggcttcg gtcccggata acggaactct 2163661 tcctctgtaa tctggtcgcc tttttccttc gctttatagt aaaaaaactt taaaagcgag 2163721 gttccatgat gctgctcagc aatatcgaca agctctttcg gaaatttata gcttctcagc 2163781 atattcgcac cgtctgtcgt atgcgagata ataatatttt tgctcaactg aggtgacagc 2163841 ttgtcatgcg gattgtcaat attcatttgg ttttcaataa aatattgcgg gcgctttgtt 2163901 tttccgagat cgtgataata tgcgccgact cttgcaagca aaccattagc cccaaccgct 2163961 tcacaggctg cctctgataa attggcaacc attacactgt gatgatatgt acctggtgtt 2164021 tccgtcagta ttttgcgcaa tagcggatgg ttaggattag acagctcgag cagcctcatg 2164081 gtggataaaa tgccaaagcc cgtctcaaaa aacggcatca gaccgatgat caatacagat 2164141 gaagcaaacc ccgacacaac ccccatgagc attaacgtgc cgatttcaag acccgacagc 2164201 gcagtgttct ggatcaataa taaggataga acgacaacca tattaataaa cgccacgaaa 2164261 agtccggtct gcaaaatctt tgatcttgca ttgtgttttc ctaaaaataa tacacctgaa 2164321 atgccgctga tcaaataata aatccctatg acataattga atgttcctgt cacaccctga 2164381 ttaaacatca tacttccgca aatcgcaaga atgatacttc ccaaaatggc aatgcgttca 2164441 ttcatcagca gtttgattaa gatggcgccg gccgcaatgg ggaccagata gccgatatta 2164501 ttatactcca tcttctgaaa caaactgaca acctccatga tcacaagcaa aagtgttgtg 2164561 attatggaga ataacagaat ggattggttt ttaaacttca gattttgttt ctgtttttca 2164621 aaataatata caagtgttgc aatgaaaagt ccgatcataa tcaatagccc gctgatcggt 2164681 ttaaagagat ttgagttatt taataacccg gtcagctcaa gtttcctgta cacttcccga 2164741 tcaatgaggt cattttcttc cacgagcact tgcccctgtt tgatttgaac ctgctggaca 2164801 ttatctgagg cttcctgccg ttttgcctct gttgctttcg gatcgaagac gtaattcgga 2164861 ataatagcaa aacgcccgat ttctgtcgcg gctcccaagt atttagacgg aatagaattg 2164921 ctctttagct ctttttctac cttatccttt gcatcagata gtttatccga agggatttca 2164981 ctgctcatga ccgtatttac cgcggtaatg accgtatctc tgacaaaaga aaagtcttca 2165041 ctgtctgctt tcagcaatgt cttgatggaa tcctccgata tagaatcatt cacatctgat 2165101 gtcaatttgt cctttacaga tttgaccatt gatttttccg atggtgattt actgccttct 2165161 tccgatgatt ttttcacttc actaatactg tcgaatattg atgacacaag gtcaatccga 2165221 ttgtctgtat attctttttt taatgtatat tgatcttcaa ccgcgtcctc agcggcttgc 2165281 tttttttcct ctgtggcttt ttgatcttct acggttgccg gagcgtaaat ggtcttgtcg 2165341 ctgactgaaa acaggtctaa atcaagtgtt tccggcttaa catgtacaaa gagcaaagca 2165401 aacataatgg cagccagcag aagatacagc agtacatgca tggagcgggc atttttaaaa 2165461 ctgctccatt tttttgagct gcttttggtc ttagccttct ttttcaacac aagaacctcc 2165521 tcttgaaaca tcaagcccat aagcaatcat aaaaatgacc cgataacgcg cgatcgggtc 2165581 attcagcatt aattttgctt atcgtatgct tcaataattt tcgcaacaag cggatgtctg 2165641 accacgtctg tctggtctag ctcaatcata gaaatgccgt ctattccttt cagcatctcc 2165701 ttcgctactg caagtcccga tttgacgcct ttcggcagat caatttggct aacgtcacct 2165761 gtaatgatca ttttagagcc aaaacccagt ctcgtcaaaa acattttcat ttgagcaggc 2165821 gtggtattct gtgcttcatc aagtataaca taagcatcat cgagcgtccg tcccctcata 2165881 tatgcgagcg gagcaatttc aatgatgcct ctttccatca gacgttctgt atgatctgcc 2165941 ccaagcacat catggagagc gtcatacagc gggcgcaaat aaggatctac tttttctttt 2166001 aggtcacctg ggagaaaacc aaggctttca ccggcttcca cggcaggtct tgttaaaatg 2166061 atttttttga tatgtccgtt ttttaaagca tggactgctt ttacgacagc caggtacgtt 2166121 ttcccggttc ccgccggacc aatgccgaat acaaggtcat tccgcttcat agcggccacg 2166181 tattcccgct gtcccattgt ttttacacgg attgatttgc cttttgcgtt ttttgtaatt 2166241 tcttcttcat acatgctttc aaagtattca agttcattct tctttgccat tttgatggcg 2166301 taaatcacat cacgttcaga gatctctatc cccttgcgaa ttaaagcgag gagcgatccc 2166361 agcagcctgt ctgcaatctg aaacgattca tcatcgcctg aaacataaat cgtctcgccg 2166421 cgcgtaatga tatttaaatt cagatctttc tccatcaatt tcaaaaaaga atcttggttc 2166481 ccgaagagtg aaagcgcctc gtccgggttt ttcagttttt gattcatcgc aagtaaatgt 2166541 tctgtcattc ttcagtctcc ctgacaatag gtgtggtttg aacgatatct tctataactt 2166601 ggtagagaat aatcaacttt actttaccat tctcaacagt ctggtgcaaa actttttcac 2166661 ttttcacctc gccgttttcg cctattttat cctctacatc ctgtttaccc aatttaatgc 2166721 cttcttgaac tgcttcttct tttgtatatt ttcgcaaagc ctcttcactt tctctcgttt 2166781 gctctttgac ataggataca gggagcttaa atccgagaaa atgaagcgaa tgcttttctt 2166841 gttctgtttt tggatgcttc aattcctctt ttttaaacgt catcccccag atcgggattg 2166901 ccaaagaacc aaaagaaagc ttgtgctttg tccttacttt gcccgtatag acgttaaata 2166961 atgtttcaag cgggactgtc acttctgatc tataccaggt ttctccataa atttctgctt 2167021 ttgaggcgac ttcctgctga tggtcttcgc tgccgatcag tcccgaaaca agcagctgtc 2167081 ccttttcaac atgatcgtgt atggcggcca tgggctgtcc tttttgcaca aacattctcg 2167141 taatggttgc tttctttttg gcgacaatat tgcgcgggct aacatatttt tctttttcgg 2167201 gctcattttt ctccacaact ttcatatgaa tggtcgtccc cttcagatca actccgaccc 2167261 aagtgatatt gtctattcca ttggttaatg atttctgtat tttttcgggc gacatcatta 2167321 aaaactgcag acggcccttt ttgacgccga tttcattaag atgctgcctc atttgatgtt 2167381 ctgtttcagg cttagcgcct gtcacatcaa ttttccacac catattggac agcaaaaaca 2167441 aaagaatgaa aaaaatcgca aaaccgatcg taaaccctat attcagcttt gatttcagca 2167501 acaggaaggg aaatcccttc cgattgataa atcgggcttt acatttaaat ttacttctta 2167561 cccgccgaaa ggcatgtaca tcctgaagct gtatatataa cgatacggct tctttctttt 2167621 ttttgacatg aaagaccgga atcccctgtc ttgtgcattc attaaggagc cgctcaatcc 2167681 ctcttcccgt caattcaagc tggaccttac ccgaaaaaaa agacagccat ttatttttca 2167741 caacatttcc ccctcggctt tatgactcaa catatcgaac gacatcaatc gtaccctcca 2167801 aaagtatctc ttccggaaga atcgccttga tgacaaaatt tttaccagat atgatgcact 2167861 ggccctgctt cagcatcagc cgcacttcat tctcactgaa aagcaaaagg cctctgtggt 2167921 tttctatgta gatatgaagt ctgccaacca ttgtaatcct cggcagatcc atcataacgt 2167981 ccgggggaat ttccaatgct cttgtcagcc aagctttcat acgattcttt ctttgcccca 2168041 tacaaaaaga accccctttc atctcatatg tatgatttga aaggaggttc taacacttta 2168101 atttttacgg gccgggcgca tcgtacggtg aggttttttc gcccgtggag gtccgaacac 2168161 ctctcctaga acgatcccct gtacgacggt gtctttattc acctgaagca ttttttgttt 2168221 tgtgtatact gttttttgtt tggcagcagc aagatctcgt tccagccctt tcaggtttct 2168281 tgctgtttcc ctgcgtcttt cttccgcttc ccgtcttgcc tgttccatac ggttagggat 2168341 aggtgcaggg gcatcttctt ttgactgctt cttttgagga gaagcagatt gcacgtgttg 2168401 aggttttttt cttttttggc tgttttgctt ttcttctttg ctctttttgc cgaaaatcgc 2168461 agaaatgatt ccgatgatcg ctgcaataat aagcggattg gtcagtaaat cttccatcag 2168521 cgttctccct tcttagagag attatgattt gcggtcttca tccgaagggt ctttcgtcag 2168581 cttgccgaat gaatcacgca tttctgtgtc agcatcgatg ttcttgatat tcatgtaatc 2168641 catgacgcca atattccctt cacgcaaagc ttctgccatc gcaagcggca cttccgcctc 2168701 ggcttctact actttcgcgc gcatttcttc tacgcgggca cgcatttcct gttcttgagc 2168761 gacagccatc gcacgtcgtt cttccgcttt tgcctgcgcg atgtttttat cagcctcggc 2168821 ctgatcggtt tgtaaaattg ccccgatgtt tttgccgata tctacatctg caatatcaat 2168881 tgagagaatt tcaaacgcag ttcctgagtc caatcctttt ccaaggactg tctgagaaat 2168941 catgtcaggg ttttcaagca cttttttatg attatcagat gaaccgattg tagaaacgat 2169001 tccctcacct acacgagcta caatggtttc ttcccctgct cccccgacga ggcgctcgat 2169061 attcgctctt actgtgattc tcgctttcgc tttcacttca atcccgtcca ttgcgacgcc 2169121 ggcaatgaac ggtgtttcaa tcaccttagg attaacgctc atttgaacag cttccaacac 2169181 gtcccggcct gcaagatcaa tggcagcaca gcgctcgaat gtgagttcaa tgttagctcg 2169241 ctgagcggcg ataagcgcgt tgacgactct gtcaacatta cctccagcca gatagtggct 2169301 ttcaagctgg tttgttccaa cattaagtcc cgctttatgc gctttaatca gcgggttaac 2169361 aacccgattc ggaatgacgc ggcgaagcct catcccaact agagtgaaaa tgctgatttt 2169421 cactccggct gccaaagctg aaatccaaag cattacaggc acaaatgtaa aaaatactgc 2169481 caaaacaatg atcgctactg cgacaattgc cagaatcata agtgttgacg gatccatata 2169541 acttctcctc gtttctattt aaatttctct cacgacaatg cgtgagcctt ctacttttat 2169601 cacttttact tttttatctt tttctgtaaa cgatccctcc gatacaacgt caaggcgttc 2169661 atcatcaata atcacggtac cggaaggacg cagcggtgta aaggttatac ccacttttcc 2169721 cattaagtcc gtgcgcgttt gatttgaaac gtagccgctc tccgtgtttg tagaatcatt 2169781 taatatcaat ttcttaaaga atttcatacg ctttcccaac acccttgtca gtaaaataaa 2169841 agctgtaatc gaaacagctg aggcgatcaa gagagaaacc gccatgacag tgaagctccc 2169901 cgcggctaaa aacaggctcg caataatcgc tcccaagccc agtaatccaa tgattcctcc 2169961 gggaagaaaa atctcaagca gaatgagaat cacccctgct ataaagagga gaaccgtctc 2170021 atacccggca aggccggctg caagatgccc gtaaaagaac agcaataacg caatgagtcc 2170081 agccgttcca gggaggccga cacccgggga aaaaagctct accgtcagac ctaaaaaagc 2170141 gattgtcagc agaataggga caatgaccgg attcgtcagc catcttgccg tcttttccgc 2170201 aaagctctcc tttgcatagc tgatctgcgc cttttcgaac ccaagcttct ttacgagcgt 2170261 ggacaaattg tcagcagtgc cttctgaata gcctacctca atcgccttgt ctgcgttaag 2170321 tgtcagcaga tctcccttag gcgcgccaac ttccttggca tctatatctg ggtcagccat 2170381 tgcgagcgca tattttggat cgcggttatt tttcactgcg gcatcttcca tctctgccag 2170441 ccaaagtgat tgagcttttt ggtcagcggc attgccttgg ccatcaacaa tcgcggcggc 2170501 tcccattttt ccgccaggcg ccatataaat gtgatctgct tgaagtgcaa tatatgcacc 2170561 agcagacaac gcgcgtttgt tgacatatgc agttacgggg atctcgcttt cggttatcaa 2170621 atcggccata tcaatagcag atttgaccaa tccccccggg gtattgatat caagaataat 2170681 atggtctgca tgtgcatcct ttgcgtcttg taacgaacgg gacaaaaacg aggcgagacc 2170741 ctgttcgaca tttttttcaa ccgggatcac ataaacagtt tgtttttctg cttttgcgtt 2170801 cagctgtacg cctaataaag aaagtaaaaa tatacccaaa agagcagcac ggaatccttt 2170861 gatttgaagc aagggcggtg tatccctcct tccttttata ataagtgcct tctcttcata 2170921 cgtaacaaat gtatcaaagg tttcattttt ttatgtataa aaaaagacat ctctcttaga 2170981 aagatgtcct tttctttgcc atttaagaca gttgactgct cacaagctta ttaattaaac 2171041 ttccgtcagc tttacctttt actttaggca taattgcccc catcactttg cccatgtccg 2171101 cttttgagct cgcaccgacc tccgcgatgg tttcatttac gattgtacgc agctcttctt 2171161 ctgacagctg ctcaggtaaa taaacttcta aaatgtccag ctctttttga actttatcta 2171221 ctaaatctaa acgattagcg tttgaaaatt cctggaggga gtctttacgt tgcttaagtt 2171281 cacgagaaag gacagtgagt tcctcatcct cggtcaaact gtctttctta agcttaattg 2171341 cttcattttg aagtgaagcc ttaaccattc gaacgacagt cagtttgtct ttctcacggt 2171401 ttttcatata cagcttcata tcctggttga gacgctcaag aagactcata aatccaccct 2171461 cttttagaat ttgcgttttc tagcagcttc agactttttc ttgcgcttta cgctaggttt 2171521 ttcataaaat tcacgctttc ttgcttcttg caaagtacct gtctttgata cactgcgttt 2171581 gaagcgacga agagcatctt caagcgattc gttttttcta acgaccgttt ttgacattct 2171641 ctttccctcc ctccgaatac accaatcgac tacctttaag ttacacatat aaacatgtac 2171701 tttgacatta taatataagc catcagtcag gtcaactaag tgagttcact tttccgtcat 2171761 gagtgcgact gcctgtctat ataatgaaag aaaggggttg gtgaatagga tgttaattct 2171821 gattagcttt actgctctta tattattctt tctcgcaggc atgaacatgc ttcgaaaggg 2171881 cttaatttca atggcgtact caaaaattga agaacgtttg cttttattta cagaccatcc 2171941 gttaaaagcg tttcttatca gtattgtatt tacggggata cttcagagca gctcagcctt 2172001 tatggtcatt gtcatcggct ttgtaagtgc gggcgttctt tcttttaagc ggacgatccc 2172061 gatgattctg gggacaaatg ttggctctac ttttacaact gaatttattg ctatcaaaat 2172121 ggatattgtg atttgggttc ttttaatagg aggtttattg ttttttctga ctggcaggta 2172181 tcctttgaaa cagctgggaa caagcttcct tggactgggc atcatcttct tttgcatcag 2172241 cggattcagc catcttgccg ggccgctgac aaagctgaaa acgggcgccg acgttctata 2172301 ccatgttaac gattcaaact ggtccgcttt gctcatcggc atggtgttaa ctgccatcat 2172361 tcactccagt tctgtctgta tcggcatttt gatgagtttt atgaatgaag ggattatcgg 2172421 actgacacag gcgatgagcg tcgtactcgg atcaaatatc gggacatgca ttacagctgt 2172481 catggctgct gtatccggcg gatatgcggc gaaacagaca gcatatgccc atgtggtatt 2172541 taacgtgcta ggggtggctc tagtattgcc ttttctgacc gcagcgaccg gctttgtaga 2172601 gcagttatca cctgatcccg cacaaaagat cgcgcatttc agccttttat ttaatgtggt 2172661 gacagctctt ttatttcttc cgcttacaaa cttgttttac cgattgattc accttcttat 2172721 cccggctaaa taaaaaaatc ggtacatttt aatgcaccga ttttttaggt taagaagaca 2172781 aacgcatgtg ttcagttatt tcatcctcaa ccacacggac aaactgtcct tcgttgtaag 2172841 gataacctgc ttttaggatt ttgactttta cgattttgcc gatcatatct tccgtacctt 2172901 tgaaaacaac cttcatataa ttgtctgtgt aaccgacaaa catattttct tcttctgttt 2172961 ccttaaacgc ttcctcaggg ataatctcaa gcacttcatt ttcatactga gaagcgtatt 2173021 cttttgcaag ctggtcagaa agagcaatca ggcggtgcac acgttcgttt ttcacgtttt 2173081 catccacttg gtcttccatt cgtgcagctg gtgttcctgt acgcttactg taagggaaaa 2173141 catgcagctc agagaattta tgttctttaa taaagttata ggtttccata aattcttctt 2173201 ctgtttctcc agggaacccg acgatgacat cagaagtaac agctaagcct ggcagtgctt 2173261 ttttcaattt atttaaacgg tctgcaaaga attccattgt atatttgcgt ctcatccgtt 2173321 taagcactgt gtttgatccg gattggatag gaatatgcaa atgattcact atcttatctg 2173381 agcggtctaa gacctcgatc acttcgtcag tgatttggct ggcttcgatt gaagaaattc 2173441 tgatccgttt cacgccttcc acacgggtgt ctaattcgct caaaagcttc gcgaagttgt 2173501 aatctttcat atcttcgccg tagccgcctg tatgaatacc cgtaagaaca atttccttat 2173561 atccggcatc gacaagctgc tgcgcttgtt taatgacttc ttcagggtcg cgggagcgga 2173621 gcaggcctct cgcccacgga atgatacaga atgtgcagaa attattgcag ccctcctgta 2173681 ttttcaatga cgctcttgtg cggtccgtga aagcaggcac atcaagctct tcatatactc 2173741 ttgctttcat gatgttgctg acgccattaa tcggctggcg ttcttctcgg tattggtcaa 2173801 tgtagccaag cattttttca cggtcctgtg ttccgactac aatgtcgaca ccggggatcg 2173861 ccataatctc agcaggtgag gtttgcgcgt agcagcctgt gacacagatg acaccgtcag 2173921 gattttgacg aatggcgcgt ctgatcactt ggcggctttt tttatctccc gtatttgtaa 2173981 ccgtacatgt attaatgaca tatacatcag ctgtttgttc aaagtctctt ctttcatagc 2174041 ccgcttcttt gaaaagctgc cagattgctt ctgtttcata atggttgact ttacagccaa 2174101 gcgtatggaa agcaacagtt gccattactg atcacctctt aataactctg tttgataaga 2174161 aatcgcactc aacgcgtata gcggagcggt ttctgtcctt aaaattctcg gtccaaggcc 2174221 gcacgtcaca ccgtcttgct ctgtgagccg ttcaacctcc gcttctgtta aaccgccttc 2174281 gggaccaaat acgatcaata gagatgatcc tttcggaagg ctgcttacaa tcgcgctgaa 2174341 tgcgcttatt tccccttgct tcgatgactc ctcgtatgca acgacacatt tatcgaaatc 2174401 ctgcatcctt tgaagaagct gctgaaaaga atggacatcc atcactcgcg gcacttcgtt 2174461 acggtacgat tgctcagccg cttccttcgc aattttcgtc catctttccc gctttttctt 2174521 tgcctttttg tcatccagct tgacaacaga acgcgcggct tggaaaggaa taaaggcatg 2174581 agctccgagc tcagtcccct tttggataat ccattcaagc ttatctcctt tcggaaggcc 2174641 gctcgcaata tagaccttta tcggaagctc tctgttttca ttcgtccatt ctatcacaag 2174701 gcaggacact ttatctttgg aaacagattg aagttcacat tttgcctcga agccgtcttg 2174761 agagcagcag ataatctgat ctccctcatt cattctcatc acgttcacaa tatgatgaac 2174821 ttcttcgccg gtaatcgaaa aagtcggcgc ttcctctatt tgctgcttcg tgagctcgat 2174881 aaaatatcgt tgcatacgct gtgacaccta ctaactgtta ttttttcgca ataatgctga 2174941 cccaatcttc cattgaaagg atttctacaa tggtaaagcc agcttgttcc agtgcttctt 2175001 ttacttcttg ttttttatga ccgatgattc ctgacgtaat aaagtgaccg ccttctttta 2175061 acaggctgta cgcttgtgaa gtaaagcgaa gaatgacttc agccaaaatg ttggccacaa 2175121 tcacatcatg ttccccttca atcccgtcta acaaattgtt ttgcttcact tgagcaatat 2175181 cgctgacttt gttcagcttg agattgaggc gtgcactttc tacagccacg ggatcaagat 2175241 cgtaggcatg aaccgattca gcctcaagca ttgcagccgc aatacttaaa attcccgaac 2175301 cagtgccgac atcaatcacc ttatcaccct tttgcacaaa gcgttcaagc gcctgaatgc 2175361 agagtacggt tgtcggatgt gtccctgtgc cgaaagccat tcccgggtcc atttcaataa 2175421 tcagttcatc agtatggacc ggcgtatatt cctcccacgt cggcacaatt gtaaactttt 2175481 cagaaatttt cacaggatga taatactttt tccaggcagt cgcccactct tcttcattta 2175541 cttcagaaat agtgatgtgg tttctgccca aatcaatatt gtaaagaagg agattattaa 2175601 tcgtttcttt gatgccgtct acagtttcgc ccagaaaact gttaaccggc agatatgctt 2175661 tgacaatgac accctcatct gggtaatcat tggggtcgag ctggtagatt tccccgtaca 2175721 cattctcacg ttctttaatt aaatcaagcg ggtcctctat cacaacccca cttgcaccag 2175781 cttcatgcaa tatatttgag ataggttcga ccgcttcatg tgttgtgtga atgcttaatt 2175841 cggaccattt caaaactacc aactcctcat ccaataatta atcgccttta aacgcgcgtt 2175901 ttaccttgtc aaagaaactc atttcctgtt cgtcaggcag gtttccgctg acttcggcaa 2175961 attcgcggat aatgtctttt tgtttatcag tcagatttgt cggcgtaacg acgcggacga 2176021 cgatatgctg gtcaccctgt ccatagcctc tgacattttg aacgcctttg cctcttaatc 2176081 tgaatttcgt tcctgtttgt gtaccggccg gaattttcaa tttcactttt ccatgcagcg 2176141 tcggcacttc tacctcatct ccaagagcag cctgagcaaa cgttaacggc atttcacagt 2176201 aaatatcatc gccgtcacgc tcgaagaact cgtgtgcgcg tacatggaac acgacaaata 2176261 aatccccggc agggccgccg tttattcctg gttcaccctg tcccgagaga cgaagctgct 2176321 gcccgtcatc tacaccggct ggaattgtca cattgatttt cttgcgtttt ttgatttttc 2176381 ctttgccgcc gcagtccgca catttgtttt taatgatttt gcctgtacct tcacagtggt 2176441 ggcagacccg tctgttaacg acttttccaa acggtgtatt ttgctccacg tttaactggc 2176501 cggagcctcc gcagtgggag catgtttctg gatttgttcc aggtttcgca cctgagcctt 2176561 tacatgtttc gcacgtttcc tcgcggggaa tttcgatggt tgtttcttta ccgaaagccg 2176621 catcctcaaa cgacagggtc atcgtatact gtaaatcagc accctggcgc ggagcgtttg 2176681 gatctcttcg tcttgtgcct ccgccgaata tacttgagaa aatatcatcg aaaccaaaac 2176741 cgccgaaatc gccgccgcca aaacctccgc cgccgaagcc ttggttaggg tcagtgtgac 2176801 caaattgatc gtaatgcgca cgtttttggt catctgacag cgtttcgtat gcttctttta 2176861 cctctttaaa tttttcatct gatccggctt ctttgttaat atcaggatga tatttttttg 2176921 acagcttccg ataagctttt ttaatttcat cctttgaagc gctcttactt actcccagca 2176981 cttcatagta atcacgctta ctcatctcgc ttcactctcc cgaatttctc acataaatta 2177041 gattgtatca ttttgaatta tgatttttca attcctttta tcccgggcaa gaaaaaaagt 2177101 caaagccaag agatgcctga ctttgacttt ctaatcattg aatcagatta tgaaatgtgt 2177161 tcttttcggt cagctccgga agcggggctg acactaaaaa gaacttattt tttgttttgg 2177221 tcgtcgttta cttcttcgta ttcagcgtcg acaacgttgt catccgcttt gccttcagcg 2177281 tttgctccgc cttgagcttg ctgtgcttta gcagcttctt cataaagctt catagaaagc 2177341 tcttgaacga ttgtttgaag ctcatctttt ttcgctttga tctcttcaaa ttcgtttttc 2177401 tcaatcgctg cttttaaagc gtctttggca tcgttggctt ttttcacttg ttcttcgtcc 2177461 actttgcctt caagatcttt taatgttttc tcagtttgga aaacaagctg atctgcttcg 2177521 ttgcggactt cgatttcttc ttttttcttc gcatcagcgt cagcattttc ttccgcttct 2177581 tttaccatgc gttcgatctc ttcatctgag agacctgaag aagatttgat tgtaatgttt 2177641 tgttcttttc ctgtgcctaa gtcttttgct cttacgttta cgataccgtt tttgtcaata 2177701 tcgaaagaaa cttcgatttg aggcacgccg cgcggtgctg gcgggatatc agtaagctgg 2177761 aagcggccga gtgttttgtt gtcggcagac attgggcgct caccttgaag aacatggata 2177821 tcaacagctg tttggttatc agcagcagtt gagaacactt gagatttgct tgttgggatc 2177881 gtcgtgttgc ggtcgatcag ttttgtaaac acaccgccca ttgtttcgat accgagagaa 2177941 agcggtgtaa cgtcaagaag aacaacatct tttacgtcac ctgtgataac gccgccctga 2178001 atcgcagcac caagcgctac aacttcatcc gggtttacgc ctttatgcgc ttcttttcca 2178061 gtttcttttt tgattgcttc ttgtacggca gggatacgag ttgatccgcc gacaaggatg 2178121 actttgtcga tttcgcttgc agaaagtcct gcatcttgaa gcgcttgacg gacaggaccc 2178181 attgtgcgct ctactaaatg agaagaaagc tcttcgaatt tagcgcgagt taatgtaagt 2178241 tcaaggtgaa gcggtcctgc ttctccagct gtgataaacg gtaaagaaat ttgcgtagaa 2178301 gatacgccgg aaagatcttt tttcgctttt tcagctgcgt ctttcaaacg ctgaagcgcc 2178361 attttgtctt ttgacaaatc aatgccgttt tcttttttga attcagacac cagatgatcg 2178421 atgataactt ggtcaaaatc gtccccaccc agacggttgt cgccggcagt tgaacgaact 2178481 tcgaatacac cgtcgccaag ctcaaggatg gaaacgtcga atgtaccgcc gccaaggtcg 2178541 tatactagga tcgtttgatc ttcatctgtt ttatcaagtc cgtatgcaag cgctgctgca 2178601 gtcggctcgt tgatgatacg ttctacttca agacctgcaa ttttaccagc gtcttttgtt 2178661 gcttgacgct cagcatcgtt aaagtatgca ggaactgtga taactgcttt tgatactgtt 2178721 tcgccaagat agctttcagc gtatgattta aggtgttgaa ggatgatagc agacacttct 2178781 tgtggagtgt aatcctttcc ttcaatttca actttataat cagtacccat atgacgtttg 2178841 atagacataa ttgtgttagg gtttgtaata gattggcgtt tagccacttc ccctacttga 2178901 cgttcgccgt ttttaaatgc aacaactgat ggcgttgtgc ggtttccttc agcgttagca 2178961 ataactttag gctcgccgcc ttcaagcact gccacacatg agtttgttgt tcctaagtcg 2179021 attccgataa ctttactcac ttgaataacc tcctgctatg taattattga ttcactttga 2179081 ccatggaagg gcgaatgacg cgatccttca gcttatagcc tttttgcatt tcctcaacaa 2179141 caatgttgga gccgtagttt tcgtcttcag cctgcataac agcttggtgc agattaggat 2179201 caaattcctg ccctacagct tcgatggctt cgacgccttc ttttttcaag gcttctacga 2179261 gctgacggtg gaccatttcc attccctgga gcaaactttt cgtctgttca ttgtcggctt 2179321 caacctgaag cgctcgttca aaactgtcaa gagccggcag caaatcagtc acgatatttt 2179381 gagaacggta tttttgggac gcttccatct ctaaacggct gcgtcgttta tagttttcaa 2179441 agtctgcttg aacacgcaaa agtttgtttt ctttttcctc aagcaaacct tgcaattcgt 2179501 taatttggtt ttgaagaagt tcgctttcat ttgtttcttc ctgctgttca tcagcggcag 2179561 cttgttcttc aatgatttct tgctcttctg tttcgttttg ttcaacggtt tgtttttctt 2179621 ctgacattgt gttcacctcc ctcaaagtgt aaggagaagg acaggtgctg cccttcgata 2179681 aaatttgcca aaattccctt attcatcata cagacttgtt aatgcttttg acaagtccga 2179741 agtcacatgc tgaagcaggc tgacaaccct ggaataattc atgcgggtcg ggccgataat 2179801 cgcaattgag ccgatctgct tctggtctac ggaataagaa gccgtaatca gactgcaatt 2179861 ttccatctct tcatagtcgt tttcttttcc gattttaatc gaaattcccg tgtgcgggga 2179921 ttgaaccagc tttaaaacat cctgttcttt ctcaattaat gaaagcagcg accgaactcg 2179981 ggtgatatca tggaactcag gctggttcag catattgatt ttcccgccaa aaaacaactt 2180041 ttcaacgtga tttgtggaat gaaaggttga acgaagcgcg tcgagtatat tgtcatagtt 2180101 tttaatgtgc tgtcttaggt acatgacaac ttctttaaat atgcgctcat tcagttcatc 2180161 cattggaacg ccgcttaaac ggtcgttcag tatatttacc agtttttcaa tatcagacag 2180221 atccattttg gtcggaaagt taatcgtttt gttttccaca tgccccgtat tggtaacgag 2180281 aatcgctacc gccatatcag gctgaatcgg aatgatttga atctgtttaa ggtaattctc 2180341 actcaacttc ggcccgagta cgatggatgt gtaattcgtc agatcggaca aaatttgcgc 2180401 tgatttttga actgtcttct ccagctcgaa aattttctct ttgaagatcg agtggatttg 2180461 gtccaggtcg cttttcgtca atttgacggg tgacagcaaa tggtcaacat agtaccgata 2180521 ccctttttct gacggaacac gtcctgagga tgaatgggtt ttttcaataa agcccaattc 2180581 ctccaagtca gccatctcgt ttcttattgt tgcagagcta aatgtgattt catctttttt 2180641 cgaaagagtt cttgatccca ccggctgtgc cgatttaata aaatcgttga ttataacctg 2180701 aaggatcagc agctgacgat ttgttaacat catcatcacc tctgttagca ctctcaataa 2180761 gcgagtgcta attctataac aaaagtatca aaccacaaga aaaatgtcaa ttataactca 2180821 cccaaaaaag cgccaaaaac ttcattgcct aataatttcc cttgatgagt caaataaacg 2180881 gcagactccg aattgtgaat cagccctttt tcagcgaggt cttttaacac gcttgggaaa 2180941 agtccatcca gggaacggcc gtatttttct gcgaatcgtt ttttgctgac accggctgtt 2181001 tttctcaaac ctaaaaacat ttcttcctca atctgttctt ctgttgtcac ttcatgtgta 2181061 tctctgtacg gaaaaccctt ttcagctatc aggtcaatgt aatgcttaac aggtccgacg 2181121 ttcactgttc gtgtgccgcc aatatatccg tgagcgccag ctccgaaacc gaaatattgt 2181181 tcgttgctcc aatacgttag attgtgctta gattccatgc ctgccttagc aaagttgctg 2181241 atttcatatt gatgaatgcc gtgagcttcc atcttgctca tcactatttc atacatttca 2181301 gcttcctgct cctgcggcgg aagatgaagc cgcccttttt gcatcaaatt ataaaatacc 2181361 gttttcggtt ctacaataag ggagtaaacg gaataatgct cagcgtccaa tgataaagca 2181421 gtgtttatgg aatgttccag atgcttgagg gtttgccccg gaagcccgaa catgagatca 2181481 agactgatat tctcaaaacc gatttcccgc gctctttcaa aagaggtgaa tacatctttt 2181541 tgcttgtgca ctcggccgat tttttctaac agatcgtctt cgaacgtttg cacaccaaag 2181601 ctaaggcgat ttacgcctgc ttcttttaat atttttaatt tctctgcgga caaatcgtcc 2181661 ggattcgctt caaccgcaaa ttccgataag tcgcttgagg gctttagcac gcggttgatc 2181721 atatccatca gctttttaag ctgttcctca gacagggagg tcggcgtgcc tcctccgata 2181781 aagattgttt tgagatcagg ctgcccggtt tttgctattg tatttatcat ttcctgttcg 2181841 agtgcgttta aatactcgtc gactggctga ctttgaataa aatatttatt gaaatcgcag 2181901 tagtggcaaa tatgctcaca aaatgggata tggatataag ctgatttcaa cggattcacc 2181961 ttctttacag aaagaagccg cagtacaaga ctgcggcggc ttctattgtt ttttcggact 2182021 gtcgtccatt ttcagaactg ccataaatgc ttcttgcggc acttcaactg agccgacctg 2182081 cttcatacgg cgctttcctt ctttttgttt ttcaagaagt ttccgtttac gcgagatgtc 2182141 ccctccgtaa catttagcca atacgttttt acgcattgct tttatggtgg agcgggccac 2182201 gattttctgg ccgattgcgg cttgtaccgg aacttcaaac tgctggcgcg gaatgagttc 2182261 tttcagtttt tcaacgatca cttttccccg ttcatatgcg taatcacgat gcacgataaa 2182321 ggaaagggca tcgatttttt caccattcag cataatgtcc attttcacaa gcttggacgg 2182381 tttgtagccg atcagttcat aatcaaagga cgcatagcct ttagtgcttg atttcagctg 2182441 atcaaaaaac tcatatacga tttccgctaa tggcatatca taaatgatgc tgacacggtt 2182501 tgcgtctaaa tactgcatat caatgaaatt gccgcgtttt ccttggcaaa gctccattac 2182561 agcgccgaca tagtcattcg gcaccatcat cgtcgctttt acgtatggct cctcaaccct 2182621 ttcgatcttt tgaggatccg gcatgttgga cgggttgtcg acaacgacct tttcgccgtc 2182681 tgtcatatac acgtcataga taacgcttgg cgctgtcgta atcaggtcga tgttgaactc 2182741 acgctcaatt cgctcctgaa tgatctccat gtgaagcatg cctaaaaatc cgcagcggaa 2182801 cccgaatcca agcgcttgcg aagtttccgc ttcatattga agggaggaat cattcagctc 2182861 aagcttttca agagcttccc ttaaatcatt atacttcgct gtatcaatcg gatacaaacc 2182921 acagtacacc atcgggttta gcttgcggta tcccggcagc gcttcttctg caggattggc 2182981 agcgctcgtt attgtatcac cgacacgtgt gtcaccaaca tttttgattg aggcagtcag 2183041 gaagcctaca tcaccgaccg tcagttcatt tgtcggagtt gctttcggcg tgaacacgcc 2183101 cacctctgtt acttcgaatt ctttgccggt tgccatcatt ttgatttttt gtcccggctt 2183161 taccgttcct tcaacgactc tgatataagc cacgacaccg cggtaggcgt cataaagcga 2183221 gtcgaagatc agcgctttga gcggcgcctc cggatctccg gtcggagctg gcaccttttc 2183281 tacgatttgt tctaaaatct cctcaatccc gataccggct tttgctgaag caagcacggc 2183341 ttctgatgcg tcaaggccga taacgtcttc tacctcttgg cgcacacgtt cgggctcggc 2183401 gctcggaagg tcgattttat tgatgaccgg aaggatttca agatcgttgt caagcgctaa 2183461 gtagacattg gcgagcgtct gcgcttcaat cccctgggct gcatccacga caagaatcgc 2183521 tccctcgcag gcagcaaggc ttcgggatac ttcatacgtg aagtcgacgt gtcccggcgt 2183581 atcgattaga tgaaagatat attcttctcc gtcttttgct ttatatttaa gctgaacaga 2183641 gtttaattta atggttatgc cccgctcacg ttcaagatcc atagaatcga gcaattgttc 2183701 tttcatttct cgttgagtga ttgccgacgt tttttctaaa atacgatccg ctaaggtcga 2183761 ttttccgtgg tcaatatggg caatgataga gaaattccgt attctcgatt gcctctctaa 2183821 acgcttttct ttatctgtca caatctatca ctcctactat taaacgcaaa atacactagc 2183881 ttagattata tcaataggat tgtaaagatt caatgtaaaa caagaaagag aaaagttccc 2183941 tatcatatct gggttgcttt tctctttcac gtacttattg attcatatcc cgtatccatt 2184001 catacattga ctgggcagta ttggttacgg tgtccgaaag cgcttttccg gcttttgaaa 2184061 acatattgaa tgtctccacc ttttccagct ctttttgttt ttctactaaa tcttttgccg 2184121 tgactgtttc tcctaggatt gaggcttctt tttcattatc ttttccgtcg gtgagcgtaa 2184181 acgccccctt cagtgaaggg tcatgatagc ctttcatact cagcatcccg tggtttgcct 2184241 gctgcatgcc gaacagaacg cctaaaaaca tgatcgtgac aagcagtaag cactttccaa 2184301 agtatgcaat caaatcaacc acctatttct tattgttttt tcgtctcccc gctcgctgcg 2184361 ttgacctttt cagcatccca gtacatttcg ctgaatacgt ccgcggccgc gttagccgca 2184421 cgctgcagct cttcgagatt attatccact ccgccaaact cgagcaaaag cgctctatcg 2184481 gttaaatcct gattgtaaac accattatcg cctggcgagc ctttggaaaa gacacctgtg 2184541 ctaagtccgg ggtatttttt ctccatcagt ttatgaagct cactcgcaat tttatagttt 2184601 tcttcgaagt ttttgctttt tttcccgacg acaaaggcta ccctggcata gcttttccct 2184661 ttaatcgttg cggttgtgtc ttttttgcgc cgagagtctc tgtggatgtc aatgatatat 2184721 tgcagatttt tgtttgaagc gagggcgtct ttcacgaccg gccttgattc atcataggac 2184781 ctggcatagt ttaagccttt tttattcaat tttgactgta tatcggtttt attcactgtg 2184841 gctccgattc cctgggattc aagcgcttgt ccgaacatat ctcctacaag cgtgacattg 2184901 gctttagaat ggcgcgccat gtcaggatcg gtctcgcctt ttaatagagg gagatatgat 2184961 tccgtattgt gcgtgtgata gataaacacg acctttttat cacctgttgt ttgtttcggc 2185021 ggatcttttt gcgcattatc tgattgcgtt tgctgttttt caatctctgc caaattcgct 2185081 tctctttctt cctccatcac cttagacggc ggcggcgatt ccgcaggcat attcgtataa 2185141 tccgttcctt gtccagctaa caaaatctcg gtatcaaatt gtgcaaatcc tggcagctcc 2185201 cgaccgagaa agctccgcgg atcttcgagg ttaatgctcg tcgccagctt taaagaaaga 2185261 cgagaaagat gaaatgagct gtctgtttga gagaggtcag aagcgaaata atggttttcc 2185321 atctgcagca aatgtgcaaa tacgtcaccc ggcaattctt cagcaatccc ataaaaagag 2185381 tcagacgacg gcctaagttc cggccggaga gacgtcagca caccggatag aacaaaaatc 2185441 acgataaggc ttacgataaa tagaaagatg gcttttaccg ctttccctcc atttaccgca 2185501 acaacaatct gtctgtttct gcgtttattt ctcattgaat ccctccagcg cttgtctagt 2185561 aattactcta tgaacaagct agaggaagta gaactgttta gtgattgtag gagcctttgt 2185621 tttcttgtga cactttttca tgaagcgctg tgtttaatcc gttcgctaaa acatttgcca 2185681 tatcgtcgat aaatgaatcg acttccttcg gtgtaaccat taagttgtgc cctaaaggcg 2185741 aaagcacctc gtgaatgagc tgccgttttt catcttcttg aagggttccg acaataccta 2185801 ggaacgattg gcgctgcttt tgatcgggaa gatcgtcttc agtgagcact ttctttttcc 2185861 caaacgtcat gcctgccgga acaagcgatc ttgatggcct gttatccttc atttctctgc 2185921 caaaatgttt taatatgtag tccaccgtgt cgctggcaat tgtcacggca tcaactactg 2185981 tcggaacacc gatagcaatc accggaacac caagcgtgtc tttgcttaaa tcttttcgtt 2186041 tattccccac tccagacccc gggtgaatgc ctgtatccga tatttgaatg gttgtgttga 2186101 ccctttccac cgcccgcgcc gccaacgcat caatggcgat gacaaaatca ggcttcgatt 2186161 gctcaatcac acctttaata atgtcacttg tttcgattcc tgttatcccc attacacccg 2186221 gtgcaaaagc actgacaggc ctgtaaccct cctgtacgtt ttccggctga agcttaaaca 2186281 agtgccttgt taccaacaga ttttctactg ccatcggtcc aagcgcatca ggtgtcacgt 2186341 tccagttgcc gagcccaacg atcaaacagc tcgcatcttt tgagatatta aggttttcaa 2186401 gaaaagctga gaattcctcc gcaaagacag cagagacctt ctcctgcatt tccgaatcat 2186461 tctccctgat tccctgtgct tcaagcgtta aatagcgccc ttcttttttt cccgaaagct 2186521 ctgcgccttc ctttgtaaca tcaactgtgc ggattttaat gccgccgtga tcacgctctt 2186581 tttcaataaa gcctttaatt tcttttgtcg gcacagcctg ctgattggcc attgcttcct 2186641 tcgtttccac tgccaaatcg gtccgtatca aatactgatt cacatccagc tcactctttt 2186701 tcatacaggg gcctccttca cattaagtac ctatattgtt gccatttgct gaataaatca 2186761 tgctaaaaag agaaccttca atgaaaaata ctttacattt atattgcaat ctaaaggtgt 2186821 gtttgataga atacaatttg ttctattgtg aagaagattt aaccttaaga cactgtgcta 2186881 caggttgtat cttaggaggt gaaacacatg ccaaacatta aatcagcgat taaacgtaca 2186941 aaaacaaaca acgaacgccg cgttcataac gcgacaatca aatctgctat gcgtactgca 2187001 atcaaacaag ttgaagcttc tgttgccaac aacgaagctg acaaagcgaa aactgctctt 2187061 actgaagcag ctaaacgtat tgataaagca gtgaaaacag gtcttgtaca caaaaatacc 2187121 gcagctcgat acaaatcaag actagcgaaa aaagtgaacg gactttctgc ataatataaa 2187181 aacgatcctc aataatgggg atcgtttttt tcatttcttt ttaacagctg taaaaggaac 2187241 agttcgagca ggagctgctt gtcctttttc ccggttttca tctcatagtc catgacggca 2187301 agctgttcaa taattaaacg gagctcctcc tctgaaaaaa gccttgcttg atccatcgcc 2187361 agctttaccc gaaatgggtg aacttttaga ttagaagcga tttgtttttg tccgtatccc 2187421 tgttccgcga agtacttcgt ctgcagaatc agccggaact gattcgaaat aagcgccata 2187481 attttgatcg gttcttcatt ttgttttagc aaatcataaa aaatttgcag actctctgtt 2187541 cgttttcggt tgacgatttt attgatcagc tcaaaaatat tttgttcaag gcttctagca 2187601 acaagcattt ttacatcatc cagcgtaatt tcttcacgat ctccaataaa cgtgcagagc 2187661 ttttgaatct cctgaaaaat cgatgacaga tgaccgttca caagcagaac caaatgctcc 2187721 gccgcttccg tgccgattgt tttctgctct gtttttgcaa ggttgacagt aaagtctgtc 2187781 gtttcctttg catttaattc cttcgcctcc atcataaacg cgtgcttctt taacgctttc 2187841 gtcagctttt ttcgctcatc aagcttttca tacggagcaa gcaggacaaa gactgtgtaa 2187901 ggcgcaggtg attgtatata tgattcaagc gcactgacgt tgtgctcaat tttttctttt 2187961 ttcttttcac ctgttaaaaa atatggattt ttcacaatga caagacgccg ctcccccata 2188021 aacggaaacg tttcagcatc tgcaatcgct tgatccagcg ggtcctcttc cagatcaaaa 2188081 acggacagat tgaaatcctt tgtctcctga tcaacgaccg tctgtctgat cctgctgacg 2188141 gtttcttgca gcagatatgt ctcttttccg tataaacaat aaaccggatg gacctctcct 2188201 tttttcaggc ttttccacac atcaaatacc attgttgtac gacttcctct ctttcatcat 2188261 ccccttctat cctaaattga gtttgcaaaa tagtaaagag gaagcctgac tgctgcttcc 2188321 ccatttatat taaacgcctg ttcgcaagcc cccgggacag cttgtaaaaa ggcgataatc 2188381 accagaacag aaaacgttac cttagcttct agatttttca aaacaattcc attatactta 2188441 agtcagtcag gagggataaa gttgaatgat tttgaaaaaa acgttcaaag caaacgaaat 2188501 gatgctgtag attcagctgt tggttttgtt gtgtccttcg gatttttcgc cttcttgttt 2188561 gtcatggcaa cggttattca cctagttggt tcataacagc gactgcccgg gctgctgatt 2188621 tctcggcagt cttttttagt tcgtctctgt tatatctgat gtatcatatg gaggatagac 2188681 agaaaaggtt ccaactctgt ttttgtatct atattggatc gttccgtttt gatctgttcg 2188741 cagcacgcgg atagaatgtc tctgtaatag ttgcagaact ttttgatgag gatgatggta 2188801 ccgattgttt ttcccggctg agataatggc cgttttcggc tgaagctgtt ggatgaattc 2188861 ttcaccggta gagcctttgc tcccatggtg ccccaccttt aacacatctg cttttatatt 2188921 cggaaacacg ttcatcacct cttgttcccc ttctttctcc agatcacccg tcaagatcca 2188981 gctcataccg cccgtctcca tccacagaac gagagatgaa ttatttttgc ttgccggatc 2189041 aggtgcttcc ggtgacagta catggaactg caaatccttt atttgcaaca catcgcctcg 2189101 cttcacctct tcaattgcca ctccctcttc cctggctgcc tgcagcactt tctcatcttt 2189161 aggttcagaa acgaaccctt tcggaatcac gaggcgcttt actttatgat gcttcagcag 2189221 aatctccgcc tctccgatat gatcttggtc agcgtgcgtc agaattaaag cgtcaagctg 2189281 cttgattccc ttagcagtta aaaacggaat cagcaccttt tcccccagtg aaaacggatg 2189341 ctgtttttcg cgccaaggct ctgacgagta agacaaagtg ccgccggtat caattaagac 2189401 acgaccccgc tgatgcggag cacctacaaa catgctgtca ccctgtccaa tatctatcat 2189461 atccacttct ccttcggaac taagacacgg atatataaag agcagaaaca tcaccgtgca 2189521 gcaaatgcct ccggttacca tcaactgcga caaggagcgt ttttcaatcg ccataagcaa 2189581 taggatgatc gtgactgtga ataaaaaaag caaaacaggt gcaggatgtg cgatcataat 2189641 cgtgaacaca tcaacatctg caatgtttgt gattaaccta ttgatccagc ttatcaataa 2189701 atcaaaccag ctgaaaaaca atctcccaaa cgaagcggaa agacttaata gaagaacacc 2189761 tgctacagct cccggcaaaa tacagaaggt ataaaatggt accatcaaca tattcatcgg 2189821 tacgctgatg atagaaaact gatgaaaatg atataggaga atcggaagcg agcccagctg 2189881 agcgatgagt gatacaattg tcagctgccc caaggaggtt ttaacctgct gaaaaataga 2189941 agaggataga attaaagaaa aactgacggc gaacgatagc tgaaaaccgg cttcaaagag 2190001 atgataagga ttgaagagca gaaggacgat gtacgaaagg caaattgcag ttgcagagcg 2190061 gacacgccat ttgacaagac ttccagctaa gtaaacaccc gacatgagag cggcgcgtag 2190121 cactgaagga gcagcgccgg tcaacatcac atagagcggc agaaataaca gcaacagaat 2190181 tgacgccttt tctctagtta taccaaggcg gatcatgata taaaacaaac ctgctgtcaa 2190241 aatccccacg tggagtcctg atattgccaa gagatggaca acaccaagct tttgatacgc 2190301 ggtaagcact tcatcctcca cgtaaaatct gtcaccaact gtaagtgcct gtacaatccc 2190361 tgtcgaatca ggaggcagaa ggctgtttgt gaatgatatg atatgttttc tcaagctgag 2190421 caccttgtac ttgaaatttt caggttcgct gcagttttgg atagacgtga cagagtagtt 2190481 ccaatgaata tgctgccgat aaagatactc gttataatca aatgcacccg gcacagttgc 2190541 gtgattcggt tcttccaatg taccagtcaa ctcacatgac attcctggtt ctatgtataa 2190601 cagctgttct ttttcaccag cagactgaat gcgatacgca gcagcccatt tttccttatc 2190661 aggtgtctca accatcatag acatacggtc gccgtcaatt ttgggaatag tgtcaatcac 2190721 tgccttgaat tgataggttc cctgccgata ggaagagaca ttctgagaat ctgtgactgc 2190781 atacagtaca aaaaacaata taaaagagaa gaaacaaaca ataataagaa aagcgtgcct 2190841 cgttttgatt aaaatgatga ggagaaagag gatgaaaaga aaaatagcgg ggaaataagc 2190901 ggcggcagta attccagccg ttgccgaagc tgccgccata ggcaataata agcgcgaatt 2190961 acgcattcat cacacgtagc tcgtgaaaag tgtattcgcc tgttcatgta tctttttcaa 2191021 ttcttcctcc gctaaaccgg catcagccaa tttccctatt agacccgcta caaatgaaag 2191081 cttttctctg tttttcagat caacgatcat ttcatcgagt tcaacctgtt caacagttac 2191141 acccgcctgt tcaaataatt cctgcgcata cggatgtgtt ttgtaatcct cagcataata 2191201 aaccgttttg ataccagctt gaataataga tttgcagcat tgaatgcacg gataatgcgt 2191261 cacataaatc tcggctccat cagtcggcac cccaaactta gagcattgaa gaatcgcatt 2191321 catttcagcg tgaatggttc ttgcgcaatg atcatctatc attaagcatc cttcatctgc 2191381 acaatgtacg ccgcccgcga ttgacccatt gtagcctcct gctatcatgc gtttgtctct 2191441 gactatagta gcgccgacag ataatctcgg acatgtgctg cgcagcgcca ataaatggct 2191501 ttgagccata aagtattgat tccatgaaat tcgttccacg ttgttccctc caaatgttgt 2191561 gttgcctgac ctttagttta cctatcataa tgcatgaccg tcaaatcact ttactgtaat 2191621 ggaagacttt attttctcaa atgacttttc acctattcct gaaaccttag tgatatcttc 2191681 aattgtttgg aaacgaccgt tttcctcccg gtatgcaata atagcttcag ctttggatgg 2191741 ccccacccct gagatgcctt gtaactcctc taaggttgct gtattgatat tcaccagcgc 2191801 tcccttccct ccatcgcttt ggacagaccc tccgccacct tgctgcactg ctgtttcctc 2191861 tccctttttc gggatgtaca ccactgtccc gtcctgcaga atctccgcca aatttacttg 2191921 cgcttcgtct gcttgttcac tggtcccgcc cgctttctca attgcctgag atactctgtc 2191981 ccctgttcgc atttcataaa cgccaggatg ctgaacagca cctttgatgt ctatcacaat 2192041 tgtttcgttt gactcgtcgt tgtttgcttc ctgctttacc actgtatttt ctgtctctgt 2192101 tggtacagct tgcttcaccg gctctttatt tttccctgtg gccagaaaga tcataatcgc 2192161 tgtgaaaaca gccgcagaag ccgctaaaat aattgctttc ttatgctgat tcaaccaatt 2192221 catcgtgcat gttccccgct ttcgtcatat tttattttca taacacatat ggtttagagg 2192281 ataatagctc aaaggagggg aaaccattga agataggctt tatcggcaca ggaaatatgg 2192341 gtacgatcct tatcgaatca tttattgaat caaaagcggc cgatccctca aacatgacaa 2192401 tcacaaaccg cacaattgaa aaagcgttgc acataaaaaa ccgctacaac agcataaacg 2192461 ttaccgaaag tctcgaaaag ctcgtttctg aaaacgagat gatttttatt tgtgttaagc 2192521 cgcttgatat atatccttta ctggcaagag cgttacctta tttaagaaaa gatcatattc 2192581 tcatttcaat tacaagcccc gttcaaaccg aacagctcga acaatatgtg ccgtgtcaag 2192641 tggcgcgagt gatcccaagt attacgaaca gagcgctggc aggtgtttct ctcgtcactt 2192701 tcggcacaag ctgcggcgaa tctgcaaaag cgaaaatcaa tgagctgatg cagcatatct 2192761 ctcatccgct gcaaattgaa agtgacatca cgagggttgc atcagacatc gtaagctgcg 2192821 gccccgcttt tatgagctat ctgattcagc ggtttataga tgcagctgtt tcggaaacat 2192881 cagtgtctaa acaggacgcg attttgatgt gtaaggaaat gcttgtcgga atgggaaaac 2192941 tgttagaaac cgaattgtat accctgcctg cattacagga aaaggtttgc gttaaaggcg 2193001 gtgtaacagg agaaggcatt aaagcgctgg aaagcggtgt gcaggatatg tttcaccggg 2193061 tatttcaaaa tactcatatg aagtacgagg aggatatttc cgcagtgaaa aagcagtttc 2193121 atgtgtagac gagtatgtca tacgttcgtc tgtactgcaa aagcataaaa aagcatttta 2193181 aaaaaccatc gttttaggaa acgatggttt ttgatttctg cgccttgaaa aagaggcgtt 2193241 ctgattgtgc tgatggctcg gtatccgtaa aatcagctgt cacgcgatgg agctgaaagc 2193301 cgcagttctt aagcatttct tcgtattctt ccaccgggaa cgttctttgc tcgtgtgtct 2193361 catcaaaacg atcatacgct tctccgttcc acacaaaaaa cgacatatca tgaatgacag 2193421 aaagctcgtc acttccggca aagctctgcc aaatatagct gatatcttcg tcctggtcag 2193481 caaatgtgct atccggaaag acttccgcaa ttttaaaaga tgaatgaaca tcaaacagca 2193541 ggatgccttc aggctttaat acccgaaaaa cacttttaaa ggtttcgatc acatcatttt 2193601 ttgtttttaa ataatttaat gagtcacagc atatcacaac agcgtcaaat tgaccgtcaa 2193661 agccggtaat ctctctcata tcctgctgaa gaaataaaat aggctggcta ctcgatacct 2193721 tttgctgggc gaaagaaagc atctcttcgc tgagatcgat gcctgtaacc tcgaagcctt 2193781 tttcggcaag ccggatggag atttcccccg tgccgcatgc cagatcgaga atacggcctt 2193841 tttccgggag agatgcttca atccattttg tccattgatc gtaaggcgcg tgtgacatta 2193901 gctcgtcata cacgcttgca aagccttgat aaatcattga ttcattccaa agtcaagatc 2193961 tgcgagcgga gcgtctcccc acagcttttc aaggttgtag tagcttcttt catccttgtg 2194021 gaagacatgg acaactacat cgcctagatc aacgagaacc catcttgctt catcaaagcc 2194081 ttccatcttt ttgacttgaa tgccgttttc atcagcttga tccttgattt cacgggcaat 2194141 cgcctgtacc tgtttatctg aatttccgtg gcagatcaga aaataatcag caaccagaga 2194201 aataccttcc atatccagtg ctaaaatatc ctctgcccgt ttatcatcgc aagccgcagc 2194261 tgcgatcttt aaaatggact tttggttcat tcacaaattc ctcctgttca gctgccagac 2194321 acaagccagt tatacgttaa aaatgtgtct ggaaaaaccg gttgattttt tttcataaga 2194381 aaaaccattg tatttttaat ggactgaatc agcgcttgat tcaaatctgt ctcagcaagc 2194441 ttacgcacct catcgacacc gggaaatgcc cggtttggct caatgtaatc ggcaacgtaa 2194501 atgacttttt ctaaaagtgt catgccgggg cggcctgagg tatgatacct aatggcgtca 2194561 agaatgtctt catcttgaac ccctgcctct ctttggacca aataagcgcc gaccggagcg 2194621 tgccagagct ccggattatg atccaataaa tgcgcaggca ttttttcacg cgcaataatt 2194681 tgtttcattt cttctttcgg gcggaatttg gcgtaatcat gaaagattgc cgctatttcc 2194741 gcttttttag aatcggctcc aaaacgctcc gcaagttcga tcgccgtgtt catcacgcca 2194801 accgtatgga tatatcggtg ttcggtcaat tgctgcttca cgcatgcaag tgcctcctca 2194861 cgattcatat aaaccattct cctctacata cttcttcact ttatcaggga ttaagtagtc 2194921 agtgggcttc ttgcttttaa accgttccct tatcatagtt gatgatacct caaattccgg 2194981 aacgtctgca aagagaagcg gataaggggt ttcaacatga aaaccggggc gctttactcc 2195041 aataaattga atgaggttca gcagctcgtc cagcttatac catttcggca aatattcaat 2195101 catatcagcg ccgataataa agaacagctg atcatttgga taacgctgct tcagtaaaga 2195161 aacggtatca aaggtatatg atggcccttc tctttccatt tcaacaagct ccagcttaaa 2195221 ggacggatta gattgaattg caagctttag catttccacg cgatgaaagc tgtcggtata 2195281 gtcttcgttc tgtttatgcg gcggaatttg attaggcata aaccaaattt catcaagccc 2195341 cgcctggtac agcacctcat tcgccattaa gaggtgacca ttatgcggag ggtcaaacgt 2195401 gcctccgaaa attccgattt tcttcatttc aaccaccttt aaggaagctc gatttgttta 2195461 ttttcctttg attccttata taacacaatc gtattgccga ttgtctgcac caattgagag 2195521 cggcttcctt ttacaagagc ttccgctaca tcgtttttat cctcttcgca attctgaagc 2195581 acgctgactt taatcagctc tctcgcttca agcgcctcag caatttgttt aatcatgttg 2195641 tcgtttactc cgcctttacc tacttgaaaa atcggcgtta aatgatgcgc ttttgaacgc 2195701 aaaaaacgtt tttgtttacc tgttaacatt ctgttcctcc taattttcct attacaatag 2195761 atctcatttt ttcaatatta ggctcttgtc cagtccacaa ttggaaagac aatgctgcct 2195821 gttcaacaaa catgcccaca ccatcgagtg ttttcaagcc tttttggctt gcttctttta 2195881 aaagtgccgt ctgtattgga ttatacacga tatcacatac gacggcactg ctcgcggcac 2195941 gctgtaatga aagcggcaca tcgtccacgt tcggatacat gcccacagac gttgtatgga 2196001 tgataacatc atactgctca agacgttctt ctgcttcttt tatgcttaat acttctttat 2196061 tgtgaaacga gggagtagct tctgtaagcc gctttgcttt ttctaacgtc cggttgcaaa 2196121 tgtcaaattt tttcggggta tttcggacaa ttgttgtaaa aatggctctc gccgctccgc 2196181 cagcgccgat cattaagaat gacagttcag agatgggctt gtctaatacc ttcattaatg 2196241 acttcacgaa gccttcccca tcggtattgt atccgacaag cttatctccc tctcttctga 2196301 ccgtgtttac ggcaccgagc acttttgcac tctcatcaat atgatccaaa taatccataa 2196361 tggaaacctt gtgcggaaca gtcacattga ttccttgtac gcctagagct cttattcctt 2196421 ttaccgcatc ctccagatca ttctcttcta ccttgaaggc atgataatgt ccgtcaagcc 2196481 cgaggtcttt caatgatgcg ttatgaatat caggtgacat agaatggcca ataggatttc 2196541 cgataacccc gtacagcttt ttcatacacc tctccccttt tcttaaatta atgaacgccg 2196601 aacaaataca tgaacgcctt ttggcgcgta tgcagttacc tttttatcag cgtcatggac 2196661 agtaacccag cctaacccag agaaaacgat atctgtcttt ttgtctttta tcgtaaacgt 2196721 atgggcgacc aattcaggaa actcatccat ttcatcttta cccggaggtg tgagcaattc 2196781 ccctgcatgc ttttcataaa gcgcgtctgc attttcaagt tttgttctat gaatcatcag 2196841 ctcattcggc atatagcaaa taaaaggaga tctttcccca gacacataat caaaccttgc 2196901 aagtccgcca aaatacagtg tttgctgatc attaagctgg aatgtgcgag gcttcagctc 2196961 ctttttagga gataatattt tcaggtcctt tttattgaca taatgcgcca tttgatggtt 2197021 gttgataatt cccggtgtat cataaagcga tgaaccgtca tccagcggga tttcaatcgc 2197081 atcaagggtt gtgccaggaa attgggatgt tgtaataata tcttcttcac ctgacacttc 2197141 tttaataatc cggttaataa aggttgactt tcctacattt gtacatccga caacatagac 2197201 gtcttttccg ttgcggtaat gctcaatcgc gtcaattact tctctgattc cctggccgcg 2197261 acccgcactg accaaaaata cgtcaaccgg ttttaagcca agctctttcg cttcacgctt 2197321 catccattgg atcagacgct ctcttttcag tgacttaggc aaaatatccg ctttattgcc 2197381 aactaataag atagggtttc cccccaccaa gcgctgcagc ccattaatcc agctgccgtt 2197441 aaaatcaaaa atatcaacaa tttttacgac cagagagtcc gtttctccaa taccgtgaag 2197501 aatgttcaaa aaatcatcat cagttaagga gacatcttgt atttcattat agtttttcag 2197561 tctgaagcaa cgctggcaaa tcacattttc tttcgtaagc gatgcaggcg gcgcgtaccc 2197621 caaacctgtt ttgtcctcgg tttggatcgt aactccgcac ccgatacaaa caaccttttc 2197681 catttcttac tcctcccact gaatgtgccc ttttcgtttg agagcactca gtattctgcg 2197741 ttcgacctgg cggttaaagc gcgtaatgaa tccgtcagag gaagcgactg gcacgaccaa 2197801 aatcgtatgg tagccgtttc ggtttccccc gagtacatcg gtcagcagct ggtctccgat 2197861 gacaacgcag tcctcttttt tcagctccat attgcgcacc gctctattaa aggctttacc 2197921 catcggtttt cttgctttat agatgaatgg gattccaagc ggttctgaga aaagtttcac 2197981 tcttctttcg ttattattag agacaattgt cactttaatg ccgtgttcct tcatttcttc 2198041 aaaccactcg atcaatcgcg gcgtcgcgtt cggcctgtcc cattcaacaa gcgtattatc 2198101 caggtcagta ataattcctt ttacatttcg ttcctttaat ttctcaggtg taatatgaaa 2198161 aatatttttt acaaactcgt caggtaaaaa aaactttttt aacaaaaccc gcacccttcc 2198221 ctttttcttt ctttcaaaat gattgtcgaa aaaaatcgaa cttgcgccta aagaaaaact 2198281 gagcaaaaaa atttcgacaa aaattgggtt tcttcaccag gtgtggataa atttacacac 2198341 actatccact cttattacat cactctttag acaaattata aacacgatac tcacaagtta 2198401 tccacttttt ggtgtggata acagaacgat tgttcttata tgcatttcat ggtagattaa 2198461 agataacttc aacctcagat gaatgcaact tatcattgta tgcgttaaaa tcatgaatga 2198521 ttccaacttt taaggaggtg cctctcccat taattgggtt cctagcatga gaaaactgtc 2198581 tgatgaatta ctaatagaat cttatttcaa agccaccgaa atgaatttaa accgtgactt 2198641 tattgagtta attgaaaacg aaataaaaag aagatcgctc ggacatatta tttccgtatc 2198701 ttcttaatag gaatttgtct attttttccg ggcgtatttc ctttttttac tcagatgact 2198761 gatattatat cactttggct gcgcgcttta ctactatttt cagcaaaaaa cacccctaaa 2198821 aagaggtgtt ttaaagggcc ggttattatg ctaaccagta tatgccgccc acaacaagga 2198881 gaacaacaac taaaacaaca ataaaagcgt atccatatgc tctgcctgcg ccatacatgt 2198941 gaagcgcctc cttaataagg ttttataaca gcctatgtag gagaaataaa tcggactagg 2199001 cggttgtccg gctcaacgct gcaggatctg ccccgcgaac taatttatta atgttcaaca 2199061 acagaatttc gtctattggc aataaagaat ccacaaatca ttgcaagaat ggccatcgcc 2199121 caccagaacg ttgagatcgc ctgatcatga tcgatgataa tcaaacgaat gacagctgtg 2199181 atgccaatat aaatgaagta gcgaagcgga aaatgaaagt ctgatttgaa gtatttgata 2199241 atcaaagcaa tgaactcaaa gtacatgaag aatataagca gttctccaag catctcataa 2199301 tagctgtcca ctttgttgaa cagtgacttg tatacgaata gcacaatgta ccaagtctcg 2199361 ctgatcagaa gtgcgcttaa ggctaacgcc agaaagaaca gacagacgtt gagaagcgct 2199421 tgtaacaggt aaggcacctt tttgaatttg ttagaaaatc tcatcatgtt gtctcctatt 2199481 tcaatatatt cgtggttttt attctcagcc tacatcttgg tgttccaaaa tcgtagcaca 2199541 atgtagtact tagaattctt ttgtatactg tgaaactgtc cctgcatgcg ggacatcatt 2199601 cgcgcaatgc ttctttcacc gagtccgttg ctttccggtg ttatatctgc aagtttaatc 2199661 gtattgctaa catggatctc aaatatctct tgatccgata caaacgtgat actgattttt 2199721 tcttccggat ctgcgtattt caataagttt gacatcacat tatcaaatac acgaccaagc 2199781 tcctccaaat tcacgttaat ataggtttcc ggcagctcgc ctgaaatatg gacccgaaaa 2199841 tgctcctgat gaaggatagc aatctgatct gatattagat cgtagatcac ttctttcact 2199901 gcaacggtct ccagatcggc ctcatattcc ttgttcagca ggaaatacgc aaacagattg 2199961 tcagacaagc tttttaattg cagtgcttta ccataagcat tggctacata ccgatctttg 2200021 ctggcacccg cttcgcctcc ctcttttttg gcaaactcca gattcatgat cagcgacgtc 2200081 agcggtgtgc gcatatcgtg cgacatttcg gtaaccaggc tgcggctctc agcttgcaat 2200141 tcctcgatag ctttaagttt atccaggaaa gctttccgca gatcctcaat gctctttgca 2200201 atcatcgcta attcatcatg cccttttatc gtcatctcgt agtccagttc gcccccttca 2200261 agaatatgaa tctcttgatg aatcgtttta aggtagcgaa gactttggcg aattccgaag 2200321 agaacaatga ttaaaaagat gagggttgcc ccgagcaaat ccaatgcaaa ggccagatca 2200381 taatatcggg aagagtagaa accgtcgata atgactcgtc cttcaccatc gctaaacttg 2200441 acaggatgtg aatgattttg agcgtactga gtcagctttt cctttccata atccgattcg 2200501 gaataaatag aatcatattg cagctcctga tccttgaata tggtgaggtt aatgtaattt 2200561 tcttttttga cccactcgcc aaacgctttt ctatctgatg tagacaactc attttctgaa 2200621 acgtacttgc tgaatttttg aatgtatctt gctgactcct cgtgataata ctcttccgaa 2200681 ctcagatatc cctcgatcag atcatctgtg atcttttgca acgtcagaaa gatcacacca 2200741 ctcacaatcg cagcaaccat tatcagcaaa gccagttttt tggttagcgt aaatttaaga 2200801 tgcgccaaat cgatatcctc ttccccattc agtttttata taaaccggac gtgccggatc 2200861 atcctcaatt ttggagcgca gcttccgtat atgcaccatc accgtattgt tggaacagta 2200921 aaagtaaggc tgtccccaca cactctcata tatattttgg gcagaaaata ttttgttgcg 2200981 tttgttcatc agaagtttca ggatacgata ctccagatct gacaacttga tttgcttctc 2201041 ctctttccac acctcattaa attcttcgct cactcttagt ttgcccccga taagaaatgt 2201101 ttcttcctgt tccttctttt cctgatagat agtatatctg cgtaattgag caatcactct 2201161 agcgtgaagt tcctcttccg agaatggttt agtcatataa tcatcgccgc cggcgagtaa 2201221 tccctcagtt ttatcgagtg tactcgatct ggccgtcaga aacagaatcg ggacgttaga 2201281 ggatttcctg atgtgctgac atgtttcaat tcccgaaatg cctggcatca taatatccaa 2201341 aataaccaaa tcaagcgagt cattcacaag ttgcaatgct cgctttccat ccttggctct 2201401 tagcacctcg taacctgcac gtgtaaggga ttcctccaaa agatcaccaa tatcctcatc 2201461 atcctctacg actaatattc gataggccat gtctctctca cctcatgatt cttgttgtta 2201521 tttctcgtgt gtccttacta tatatcgttc atagtaataa gtacgttata agatactacg 2201581 taaatcttaa caatttatga aagctgatgc tcgccacaaa tttgtcacat tttctaaaaa 2201641 aaatgatgac tcttcataaa ttgttaagat tcggtcttta tatttatcca ttgtaaggct 2201701 caagtttttc agatccgcac tacacattgc cgtgataaat gggaaaggag tattgatatg 2201761 attgtacaaa aagaaggacg cgggcaaccg gtgagtctgc gggaacgggt tcattttctg 2201821 gacatcgtac gaggatttgc cttgcttggc attattattg tcaattattt tctgatcgta 2201881 gattcagtaa agggattcga aatggcctcc gatgacgtac tgcataagct ggtttcctgg 2201941 tttgccgaag ggaaattcgt tacgttattc tccttcctgt tcggagtcgg gtttatgatc 2202001 tttatggatc gagccgcgca gaaggtagag agtcccaaca agctgtttgc ccgcaggtta 2202061 tctatcctgt tgggatttgg cattttgcac atcacatttg tttgggtcgg tgacatattg 2202121 gccttttacg ccgtaagtgg cttcctgtta ctcgccttct ataaacgcac ggccaaaacg 2202181 gtgcttagat ggattatcgc acttatcgtg tttcaattcc tgactcctgt tttcacaatg 2202241 ttgtacaatg tcatcaatac tgcagggtca aaaaacccga atttttcaga gtttactttg 2202301 tttagccaca gcagccttac ctacatggaa tccatcagca ctcggtggac agatatggtc 2202361 acgatggctg ccggctcttt ctctatgatc tattccatgt ttctcatgtt tctgctgggc 2202421 gtgtactttg ttaagatgga atttttcaaa gacatggaag cgaaaaagcc tatatggaag 2202481 cgtatctgga tcattagcac aatcgctttt ctaataacac aaagcagtat attactagac 2202541 atgtttaatc tttctgagaa tatgctgtgg aaggacattt cctctgtctt gggtcaaaat 2202601 ggcggcttaa ccggaagtat gttttatatg agcacttttg caatgctgtt tctatacctt 2202661 cctcagctgc gaggccctat gatgatattc accaaagtcg gacggatgtc attgacctgt 2202721 tatctgcttc actctatcat tggaacagtt ctgttcctca ggtacggatt cgggcttgcg 2202781 gatcatattc aatccgccgg cacgttcatg ttcagtctgg ccgtgtactt cgttcttatg 2202841 agctttagta cattgtggtt gaaacggttt aggtacggtc cgatggaatt agtatggcgc 2202901 aagctgacgt acggcaaagt aaacgggagt cccaaagcaa ctccgctgca ttcggaaaaa 2202961 tctattcaga aataaccccc ttgcacagat tgcatgactt caaattagtg ttgttgaatg 2203021 aagcgggcat taaacggaca gatttgatat atggactagt tatttttata tcatttaggc 2203081 ttctttgggc taataaatcc accagagttt actcaatgtg cattgctcat gatcgaatct 2203141 aaattgaatc ttttacgcat gttcatagtc aaaggcgcct cattcgacta tttttgtaac 2203201 ttttcgcagg aaaaattcga gaatgatgac aaatcccgca tacgacactt aatacggtag 2203261 tgaacaatag taaattaggg ttacatgcag cttgttttcc aatgaaacaa agaaaaagaa 2203321 tcatacaaaa agacaggaga aagcttttga agtattttaa cgccaaattt accgcggaag 2203381 aaagagcgat ggaatcactt ttttgtgaaa aggcctcgca gagcagctcg aatgttttac 2203441 tgaacgactg aactctatat tttagcaact gagggagtga acaatcatga aaactaaaaa 2203501 tgaaccaaaa gttattctgg aactagcaaa ggaatctgat ctgccagaat tccaaaaaaa 2203561 attacaagaa gcctttgcga tcgccgtgat tgaaacgttc ggtgattgcg aagatgggcc 2203621 gattccatcg gacaatgatg ttcaggagtc tttcaatgct cccggagcag tggtatatca 2203681 tattcttcag gatggtaaga atgtcggtgg tgcagtagta cgtatcaaca gccaaacaaa 2203741 tcataattcg ctagatttat tctatgtatc tccagaatat cacagccaag ggattggtct 2203801 ttctgcttgg aaagccattg aagcacagta tccggatact gtgctttggg aaaccgtgac 2203861 accttatttc gaaaagcgaa atatcaactt ctatgtgaat aagtgtggat ttcatatcgt 2203921 agagttctac aatgaacatc actctaatcc gcatatgcat cgcaatggac gtgaagatga 2203981 caagccccta ctgaatgatg atgacttttt cagatttgta aagattatga aaaaaaagga 2204041 ctaaacaatt gaacacggcg agatgccgca gagagttgct ggtaactttt ttatatttca 2204101 ttatcagagg aaggtaataa tgatgtttaa aaggtgtttt gatccctgtc tcataaacag 2204161 gggtcaaaac acctttgaat catcggtttc ttttctgaca tataccacgc ccactagtcc 2204221 ctcaacatag taaaaacata tcatgagtta caaaagcttt tattcaaagc atatgtttat 2204281 tttatttata cttattttca tcatttttca gaattctgga cacaaatcgg gtacctatta 2204341 gaggccaagg aactctacat ttcattaaga aatacgtact cattgccctg ctttaattaa 2204401 ttttaagccc tcgcactatg cccccccctg aattaagtat ttgatgtaac tttgaaatta 2204461 agtttatgaa aatctgtcac aaacccttat ttcataacac atcatttgtt tcagcttccc 2204521 tcgcgaatac cggattaatg ctcggcttta agatagtcaa ccaatctctc cgcactgttc 2204581 ttaacatctt cttttgaaag atgaagtgtc ccatattgtg taaacgcagg aagaaaacgc 2204641 attcctatat agttagcagt gacttgaaac ggtctgataa gctcgctgat cgtgatatta 2204701 tattctccgc ctgcttgata atcagattcc tgtgcgccta aggagatagc taagagtagt 2204761 tcttttccat gcaatttagt tcctccagtt ccataagccc agccatgtgt taacacatca 2204821 tcttcccatt gtttgagtaa cgcgggactg ctgtaccaat acattgggaa ctgaaaaacg 2204881 atacgctcat gatctaacag gagctgctgc tctttttcta catcaatgat aaaattaggg 2204941 tattcaccgt acaggtcatg aaccgtaatg tctttctctt gctttaaacg attcatccag 2205001 gttttgttga caacagacgt ttccaaatta ggatgtataa cgataactaa tgttttcatt 2205061 agactgatta tcctttcttt gccaattagt tattattttt tacgataatg aattgattct 2205121 aattttaaaa tagcaacttt atttacacct attttatcct ttttcatgaa ttcagggcaa 2205181 ctaattgggc accaaaatca atgatgactt aagacattgt tttgtagaaa tccgatatac 2205241 agaataatcc attatttaga aaatttctac cttttccctc aatccgagct cgctcttcat 2205301 gcggatggcc tattttaaag gaataactga ctatgttcat cagttattcc tttaaaatac 2205361 gaaagtctac gatatttcca tatcgatccg cttcaatgtg acagcacccc tcaagcagct 2205421 gttttaattt tccacgtccg cgttgtaccc ttgattttgc tccggagtaa gaaatgccga 2205481 gcttttcact caactctttt tgtgataacc cctggaaatc agttaactcg agcgcctctc 2205541 gatacttttc aggcaaccgt ttgatggtcg atcgaataca cacagttgct tccttggtga 2205601 aattttcttc ctctgcactg tcattaaaat gtagaacatc aggcaatatt tcgcttgttt 2205661 tttttgtacg gtaaaaatca ataatcgtat ttctagtgat ccgataaatc cagctgtcga 2205721 tcttttgttc atcgatcaga tttgggagat gcacttgtat tttcataaat acgatttgca 2205781 agaggtcatc aacgatagat tgatcgttaa ccctatgtga aatatatgtt tttaacggct 2205841 gatgaaattg atcccataga tcctctatat tcatttgaaa aaacctccta taattttgcg 2205901 tctgctttac atttgcttcg tctttttaat cgtaacaaag agcaaacaat tgttgaatca 2205961 attgtattgc agctgttgcc aaaaataatg ataaaggaga ggtttgttgt ggagtatacc 2206021 tatttaggga gaacaggatt gcgggtgagc cgtttatgtt taggcacgat gaattttgga 2206081 gttgatacag acgaaaagac tgcgttccgt atcatggatg aagcacttga taacggcatt 2206141 caattttttg atactgccaa tatttacggc tggggcaaaa acgcaggatt gacagagagc 2206201 atcattggaa aatggtttgc acaaggagga cagcgccgcg agaaagttgt tctggcgaca 2206261 aaagtatatg aaccgatttc tgatccgaat gacggaccaa atgatatgag gggcttgtct 2206321 ctatacaaaa tcagacgtca tctggaagga tcactgaagc ggcttcagac agatcatatc 2206381 gaattgtacc aaatgcatca tatcgatagg cggacaccgt gggatgagat atgggaagct 2206441 tttgagactc aggttcgctc cggcaaagta gactatattg gatccagtaa ttttgcaggc 2206501 tggcatttag ttaaagcgca agctgaagct gaaaaacggc gattcatggg actcgtcact 2206561 gaacagcata agtatagttt attagaacga acagctgaaa tggaagtgct gccggctgca 2206621 cgggatcttg gtttaggagt agtggcgtgg agtccccttg caggagggct tcttggcggg 2206681 aaggcattga aaagcaatgc cggaactcgt acagcaaaaa gagcagattt aattgaaaaa 2206741 catcgtttgc aactcgagaa attttcagat ttatgcaaag aactaggaga aaaagaagca 2206801 aatgtggctt tggcatgggt gctggcaaat ccagttttaa ctgcgccgat catcggacca 2206861 cgaacggttg agcagctgcg tgatacgata aaagccgttg aaatcagtct ggataaggag 2206921 attctccgca tgttaaatga tatctttccc ggacctggag gagagacacc tgaggcatac 2206981 gcctggtgat acattcatta ctcaatactg acatttttct taaatattta tactgaacta 2207041 tcatattaag aaagacaaga gcatgtttgt ctcttgtctt ttccacatcg tgctgaaaat 2207101 gctggctaaa catcgacaaa aatgctgccg cttaaaaaag aaccctaaac aatagagtaa 2207161 ctggaaagac aactggcttg atcagcttgg gacccctttc agctgtattt aaatcaatca 2207221 aactaatgat tcattggcag tctaaatatt attattgttt ctttacaaaa tagtaatagc 2207281 ccctgtaatg attgctaaca acgtaataac taatgatgta attacagccc acttaacggc 2207341 aaacctttga aatgacccca agtccatttt aagcatgctt actagcaata ctgttgacgc 2207401 aaccaatgga ctcatcagat gaaccggctg ccccattata gaagcccttg caatttctac 2207461 tggttctata ccatatgctg aggcagcttc tgcaaagata ggtaccatac caaagtaata 2207521 tgcatcattt gataaaacaa aagtaaacgg aatactagtg agtgctacaa taacggggaa 2207581 aaaccctccc attgatgagg ggatgatgga tattaatgat cctgctatgg catccaccat 2207641 ctttgtcccg gataatatac cagcaaatac tcctgctgaa aataccaata ataccacggt 2207701 tatggcatta ccagaatgct cggcgattcg ctccttctgc atttttacat tcggataatt 2207761 tatagtaagg gcaagaacaa aaccaattaa aaataaaact gacggatgct tagttccaag 2207821 cacaataaac accatgatac ttataacgag gaataaatta agatatatta agcgtggcct 2207881 tttcaattgt tcgctctcca aagtagcagc catataagat tgagagctgt cctttgttat 2207941 atgtctaggc tctaattgaa cgatgcctat tcgattcctc tctttccttc ccattagaaa 2208001 agccagaaat atcacacaag caatacctcc aagcatggtc ggaagtaatg gcacaaagaa 2208061 atctgaagga tccaaaccca gcactgaaat cgctcttgta gctggtccgc cccatggagt 2208121 cattccgcta acgatactca acgacagcat tgctaatgtc gccataacca tgggattcat 2208181 accaattctt ttatacaaag gtaacattgc tgagactgtt atcatatagg ttgttgtacc 2208241 gtccccatct aaagcgataa gcattgccaa gacggcagac cctatcgcta ttttcacagg 2208301 gtctcccttt actatagata aaattttttc tattagcgga tcaaataaac ctgcatcaat 2208361 taaaattccg aaaaaaagaa tagcaaacaa tagcaatgcc gctgaacttg caactgtttg 2208421 aattccttct aaaatcatgt cgccaatacc cttaccaaaa cctccaataa gagcaaaaac 2208481 aatgggagtg atggtcaagg caacaatagg cgagactttc tttgtcatta ttaatattgt 2208541 aaaaacagtt accatcgaaa aacctaaaat agtaagcata ttacacctcc aagaatgcgc 2208601 tttcaaatga cttttgatta acatatctta tacggtgtaa taagttaaat aaatattttt 2208661 ttactgtgtt tcaaaaaaaa ttctatcata actttaaatg gttaccattt gttcaccctt 2208721 taaaaaatca atgaatgctt taacgagttt gattcctaat gatttttgat cgtacattag 2208781 ccaagtatct ctcattagag gcttaccctt agcattatac agttccattg tgtacaaatg 2208841 atcagattcc tgcaggcaaa tttctggtgc tatggagtaa ccaagaccat gctttaccat 2208901 ctctttgcaa gtctcttgtc gatccacttc cattgcaata atgggggctt gttttagatt 2208961 cgtatgcatc caatcttcta taatcgtttt taaagaagca tccgttttat atttgataaa 2209021 aggtaaaaaa ggaagttgct ctatcgttat tggttttttt gagatgatat gtaatttttc 2209081 ccgtgtcagc cgttcctcca cccctttcca gcgatggctt cctctcagta taccgacttg 2209141 tacaatacca gcatctaata atttcatgac atctgtgctc cagcctgttt gtacactata 2209201 ttggacatta ggatacatag tggaaaattc ccttaataac ttagggagct tatattgagc 2209261 gaaattgctt gataccccca gccttagatg tccttgcacc tctttgctta gattagagat 2209321 atgatctttg gtatcttgaa gttcctgtag cattcttctt gcataagcaa ccaagtgttc 2209381 tccttccgca gtaaaggtaa ttcctttatg ccttttggtg aataattcaa ttccgaaaat 2209441 ctcctcaatc tttttcaacc gataagtgat ggaaggctgt gatgtaaata atcgttctgc 2209501 tgtttttgtt acactttgtt cttcgtgaag aattttcaat aaaatccaat ctttctcatc 2209561 cattttcatc ttcctttcta gtccttcttt cacaattata aaagtttttt tatcgaatat 2209621 taagaaaact tatattttat ttttattttt ttaccttcta cactaaaaaa cataaaaaat 2209681 actaccttta agatgaggat gatgacgatg gtcaagacga atgtaacaat catgagaggc 2209741 ggaacaagca aaggcgtttt tttccacgaa tcagccatgc ctaacaataa aaacgaatgg 2209801 gagccctttt tgcttgatgt catgggaagt cctgataaaa gacaaataga tggtttgggt 2209861 ggcggtaatt cccttactag taaagtggca ataataaaga aagcatatac ttcggatatt 2209921 gatgttcact atactttcgg tcaagtcagc atttcggaag aaaaggtgga ctttaagggg 2209981 aactgcggaa atatctccgc tgctgttggt ccatttgcta ttgaagaagg acttgtaaaa 2210041 gcgaaagaac caatgactgc ggtaaggatc ctgaatacca atacgaataa aatgatcatt 2210101 gcggaagtag aagtggaaga cggtcaggtc aaatatgacg gagatgttac gatatctgga 2210161 gtacctggat ctggatctcc aatctattta aactttcatg atgccgctgg ttcagttacc 2210221 ggtcatttat tgcctactgg aaatagttcg gagtttttag atacaagtca aggccaaata 2210281 gaggtgtcta ttatcgacta tgcaaatcca ttagtttttg tggaagcgag cagtatcggc 2210341 ctggatggaa cggaacttgc agaagaattt actgatctac agttggctca atttgaagaa 2210401 ttaagatcca ttgcggcaga gaaatgcggc tttgccagtc gattttcagc tacaaagtta 2210461 tcgccggctg tccccaaact ggctatagta gcaaaaccag agaaatataa agatagtaca 2210521 ggtgcttggc attcaagcgt tgagatggac ttacacatca ggatgatgtc catgcaaaag 2210581 ccacatcaag cactggctgt cactggagcg atatgtacaa caagagccct ttcagtggaa 2210641 ggtgcaatcc ctgcaagaat agcaaaaaac cactctacaa aggttcggct agctcattct 2210701 tctggtatta ttgaaacaat ggtggagccc actggtataa agatcgtccg taccgcacga 2210761 cgtattatgg acggaacagt ttatacgcat ggagactatc aaatgatgta gatggactgt 2210821 gcaaaaagcc tccccccttt ccatcgttaa tagatggatt gaatgcgcct tcttgcacag 2210881 atccattgta atcttgcatg gctttaaaaa agcctctata ttgtttttta tgaaatcgcc 2210941 aaggtccttt catgtatctg cctcaagcat gacataatca ttatagagaa aattgaatac 2211001 tttttactgc aaataaaaag ataccaacat cattggtatc ttttagattg agttcatctg 2211061 cagcggtttc ttttcctcac tgcttatttg attacaaaat taccgtactc gtttgaacga 2211121 acatgaatcg gtccgtttag attatagttg ttctccttgg cgatagagcg aagcacgtcc 2211181 acacgggcaa ctgattctct ccattcgtca cgggtgtcat gattggccgg attcatcaga 2211241 tcgtcatagc gtacgtccaa gaatttattc aaccacttct tctcgtctat tccgtcttta 2211301 ggtgatccgc ccgctttttt gttcgtacgt ttaatcaagg cataaaaaga gtcagggtca 2211361 tcaccatcgc catgctgaat aaccgtatcg tacatcacag ctcttgccaa tgctgttttt 2211421 agtccggcat tatccgatcg tttcatggca ggctgataat acaaatggtc atttactttg 2211481 tcttgagcgg cgcgaaattc cttatcattt gcaagcgact tccaggcaga agcgaatccc 2211541 ttgagattgc ttgtatcatc gctttcttcc ttggccagac ggcgcaattc aggcagatac 2211601 tttttcagtt tgttattcgg aactgccttt gtgtatactt ccactacttc caatgcatcc 2211661 ccggtagccg ttgtaaagcc tgcccgtccg catgtatagc ctcgcccgtc atccaatcgc 2211721 tctacatatc catattggat ctccgttgtg ccgttttcaa agatacttgt cagctgttcc 2211781 gcccggcgct tttgatcttt attcagtccc gccgcaaaaa ccgtttcgct catcatcagg 2211841 gtaaaaaaca tggtgaaaac aagtaatgag atcgctgctt ttttccaaaa atctgctttt 2211901 tgcatactga ttttcatttc acttcccctt tctaaatatt gtaaatacag actcagtata 2211961 catgaagaaa ctgccctatt gttgaaaata catcaatttg tcaatatttt gaatctaaag 2212021 taatatagct tgaatcttac tctattcatt gccaatcagc cttagcccct ctcactggga 2212081 aggtcccttg attttcatac tgcttcaact ttcattaaca agatgccata aggctttact 2212141 ctattttata atggaagtga tcatcgaaaa tcgttaggga ggtgatgtaa tggcaagcaa 2212201 gatgagaatg ccagattccg caacgtccca tgcaaagcct actattggga aggcgatact 2212261 ttgcatgggg tagactttct aaaagatcgc ccaagtaagc ttttctgata tagtggcttt 2212321 gcaccttatt tgacataaaa aaataaggag ctggcagaaa tggcatatgt aaaagcaacc 2212381 gctattttac ctgaaaagct gatatcggaa attcaaaagt atgttcaagg aaaaacaata 2212441 tatatcccta aacctgaatc ctctcatcaa aaatggggtg cgtgttcagg aacaagaaag 2212501 ctgatcgatg acagaaacgc ttctattaaa aaagcattta aaaacggcaa aaccattcat 2212561 caattatctg atgaatatca cctctctatt gaaacaataa aaaaaattgt ctactctaaa 2212621 taaacaaaac ggaagcactg ataaaaaata atcagtgctt tttatatggc gagtttgttt 2212681 cttagttatt tcctgcatat gataccattg gccaattgtg taaagttaag ggagatgaga 2212741 agaaaggaag gtcctacaaa tgacgataaa caatggaacg ttgcaagtac ccggcgcgaa 2212801 catccactat caggtgcgtg gctctggtcc aatcattctt ttggtccacg gaggaggcgg 2212861 tgatgccgac aagttccatc atgttgccaa tcatctggct aactggtaca cggttgttac 2212921 ttatgatcgc cgcggccatt cccgcagcaa tctcgccaat cagattgagg gttaccgtgt 2212981 ggaaacacac agtgacgatg ctcaccgtct tctagccaaa atcaccaata agccggccta 2213041 tgtatttgga agcagctccg gggctgttat cgggcttgat ctgtgcatac gccatcccga 2213101 acaagtacat gtcatgatcc cacacgaacc aatcttattg cagcttctgc atggaaatga 2213161 gctgaaacaa gccgagcaat tcatggaaga ccttaagaaa aatcatcgaa gtgaagtcat 2213221 taaattaatg tcaagattag agacagacga acaatcaaag gctgtcctga caaagcggct 2213281 tctcggcaat tcaacgtatt tcactgagta tgaaattcaa ggaattctca gctatacatt 2213341 agatttcgaa gcattaaaaa ctgtgtttac atcttcaccg atgaagatac tcccagctgg 2213401 cggaagtgct tctcgggagc tttttcctta tcgttgcgcg aacgccctag cggaacaatt 2213461 ggaaacagaa tgggttgaat tccccggaaa tcatacgggg tacacaatgt accataaaga 2213521 attttctgag aggttacacg acatgttaga aaaagaaaag aaacatacgt gttaaggatt 2213581 gattaaaatt ttcaaaatag gacaggtgaa actaactatg gaattggaga agatttcacg 2213641 aagcgtaaaa agaacttttc actaacgaga acgcaatgtg agatgtttaa ccaaagtgat 2213701 attagggatt tcatcgaaaa ataggtttgt acattacgtt ctcctattga ttatttccta 2213761 tcttaattcc gtattttata ccattagata caactctaaa gcggctcgtt attttgtcct 2213821 caacaacaac cagtgtctaa catcatgaat ctcttttgaa aatcaccaca aatgcaggta 2213881 tggaagactt catcgcagca aaaaccatac caactattgt tgttggtatg gttcgtccta 2213941 gataggccct taagaagaga ttctattgta cggagtattt agctaattgc atttgtaacc 2214001 gacagggccg tctgaacctg tgtacacata tgtgtcagac acatatccaa tattcacgac 2214061 accccgggaa tctttccact ggatttggtc ccagatatta ctcgttccat acttccctgt 2214121 aacagtcgtt ccataagcgt aacaataata aggaacacgg gagccactcg gaatggaaag 2214181 cataatagga taatttgtac caggaccgct gcgcatattg acaggcgcac cgctgcttgt 2214241 tgagacagta aagtactgaa cggcaagtgc ctgactggaa aaaatgaata aagatgcaat 2214301 catcacggtt aacatactca gcattttcag tttagtcaat gtcatccctc tttcttcaat 2214361 tccttcattt taagaaacga tagaacatag gctaccagct gcatttagga acaaccggac 2214421 cgtctgagcc tgtatacata tatgtatcag agacaaatcc aggaacgatc tccccgctgg 2214481 caagcgtccg ctctgtgtaa ttccaaatat tgctcgttcc atactttcca gttacagttg 2214541 taccggtttt gtagcaatag atcgggatgc gggttccgct cggaatggtc gttacaattc 2214601 cccaacttgt acctgggccg ctgcgcatgt tgacaggagc accgctgctt gttgaaaccg 2214661 tataatactg agccgcaagt gcatggctag aaaaaatgaa cacagatgca atcatcaccg 2214721 ttagcatact tagcctcttt aacttattca ccttataccc tccccttata aatgccgtac 2214781 gtttgacttt cttacatcca gttaaggatt tactttcaga taccatgccc cctcccctcc 2214841 catatattta tcaatgtacc ataaactaga tctttcaaaa gtggaattat tcctatgttt 2214901 tcgacaatta aggatacaaa ataaatggta gtcaggcttg atattgatgg tgtgttacat 2214961 ttggctctta atcatttgtc cagtcggtaa tcacgattga caatcaggaa aaaggacatg 2215021 gatcaagcgg cttcgtttcc accaattaac tcaatcagtg tactgcttcc ttgtatccac 2215081 gcttcttctc gattcataga tactccacct ttttcaccaa tcaaaaacgg acaccataca 2215141 aatcagcgta aatgctgcaa gttcagtgtc cgcaacctat tatgactttg ctttctttta 2215201 ccagggcgtg taaaaatgat taggtacgtt atcaaacgtt attctatgat tttgcgagtc 2215261 aaaaaatcat aacattttat atatttcaat cagattatga tctggatctc tgaagtgagc 2215321 aactcgggca ctccattcct tgcgatcatg cggtttattc tcacatttaa ctcctttttc 2215381 gtgtaaatcg tcatacgttt tatcaacatc ttctacctta aactgaagca aaaattttga 2215441 ttgagcttct ccttccaagg actttttttc ctctccaacg atttcagcca tcgtttctcg 2215501 agataaaagc tctattttcg tttccccatt atcaaagagt gcatattcca tttcattctc 2215561 taaccaactt attggaagtc ctaatgaatc tttataaaac tcgacgcttt tcttaaaatc 2215621 attcaccaac agtctaattt gtaacagctt catatcgagt gcctcctata aaaccatact 2215681 tttactggtc atccaattta atgataccaa agaaacctga cagcactatg tcaagtttcc 2215741 atacttcacc cttatttcag atttaagtgc agtttagtcc atgtcataag aacgagcaaa 2215801 aacagcgatt cttaaaacaa aaaatgatac cgagtgtatt ttctgtatgc ttcaacttca 2215861 tttcgggaaa tgtaacgttg ataaaaggag gttacatcaa tatggatcat caaacattgg 2215921 cagctcatga ggctgttgac ttacatgaaa tcgtgaactt taaaacactt tgtatagcga 2215981 aatcaaagtt aatgcaaggg cttgtgtttg accaagaact gaaggacttg atggaaaaag 2216041 atgtacagca atccattcaa gaccttactg aattacaagc ggtttatgag cgtgcctcat 2216101 ttcaggcccc tgtccctcaa agccgcccaa cgccaatcat caattgaaag ggaggtaagc 2216161 ctctttgaat aatgatcatt tagaccccat taattcgctg aatgtgcctg aactagcaga 2216221 cactacattc gcgatggatt ttcttatacg agctaaggaa ggcgtaagga atactgctgt 2216281 agctttgaca gaaaccgctt caccagatgt aagagcactg cttcggaaac agctgatgca 2216341 aggaattgcg atgcaccaag agattacgga actgatgatc agcaaaaagt ggttccatcc 2216401 atatgagctg agcgaacagt ataagctgga tcagctctct gcaaaaaaca cgatcatggt 2216461 cggcaatatg aacctctttc ctgatgaaac aaatcgcaaa gggatgtttg accggacacc 2216521 tgatgaacac taacactgga ggttttacag catgaaggca gtaacgtatc aaggcattaa 2216581 aaatgttgtt gtcaaagatg tccccgatcc aaagattgaa aaatccgatg acatgattat 2216641 caaagtcacc agtacagcca tttgcggatc agatttacat ttaatccatg gattcattcc 2216701 gaatatgcaa gaagactatg tcatcggcca tgaaccgatg ggaatcgtcg aagaagttgg 2216761 ttctggggtg actaaactaa aaaagggaga tcgggtaatt attcccttta atatagcatg 2216821 cggggaatgc tttttttgta aaaaccagct ggaaagccaa tgtgatcagt ctaatgacaa 2216881 tggggaaatg ggtgcttatt tcggctattc agggcaaact ggcggttatc caggcgggca 2216941 agctgaatat ttaagagtgc cgtttgcgaa ttttacccat tttaaaatcc ctgaatcttg 2217001 tgaggaaccc gatgagaaat taagcgtgat tgccgatgcc atgaccaccg gcttttggag 2217061 tgtggataat gccggcgtaa aaaaaggcga tacagttatc gttctcggct gcggaccagt 2217121 cggcctgttt gctcaaaagt tttgttggct aaaaggcgca aaacgcgtca tagcagttga 2217181 ctatgtaaac tatcgcttac agcatgcgaa acgtacaaac aaagtagaaa tcgttaattt 2217241 tgaagaccat gagaatacag ggaattattt aaaggaaatc acgaaaggcg gagcggatgt 2217301 agtcattgac gctgttggga tggatggtaa aatgagcgat ctcgagttcc ttgccagcgg 2217361 cttaaagctt catggcggaa cgatgagtgc attggtcatt gcttcccaag ctgttcgcaa 2217421 aggaggaacc atacaaatta caggtgtgta tggaggcaga tataacggtt ttccgttagg 2217481 agatattatg cagcgaaacg tcaatatacg ctctggacag gctccagtga tccactatat 2217541 gccgtacatg tttgaactag tatcgacagg caaaattgat ccgggagatg ttgtcagcca 2217601 tgtcctgccg cttagtgaag ccaagcatgg ctatgacatt tttgattcaa aaatggatga 2217661 ttgtatcaaa gttgtgttaa agccttaaaa aacggaggtt acagaaatgg aatacgcctt 2217721 acacgaagtg cttgaggttc aggaaatgac tgcatttaag acactttgtt tgacgaaatc 2217781 taaaacaatg aaagcactgg tatctgatcc gaagctgaaa gaaatcatgc agcaagatgt 2217841 tgatatcacc acacgccagt tgcaggaatt tgcctctatt ttatctaatg caaagcaaga 2217901 atgaggagat gaataaatca tgaatcctat catagaatat ctgactggca tgaatgttct 2217961 aacagaccaa atcattgcta tggacttatt aatttcagca aagaacggag tcagaaatta 2218021 tgcgatggca gccactgaag ccggaacgcc tgaagtaaaa gaggtcctta tccgccattt 2218081 ggaagaagca ctcgatatgc acgaacaact ctcaagctat atgatggaaa aaggctggta 2218141 ccatccttgg aaccctgacg aacaagtcaa gctgaattta aaaaatattg atacagccat 2218201 tcaattgcca accctttaac atacaatgac tgatttgctg aggaacagta ttgattggcc 2218261 acaactgttc ctcagcttca aaatgagcac tgtttgttcg ggtcctatga ccgtaaatag 2218321 attaaccgct tttctccatc tgatctccga taatgtttgc aaattctcca atccaaataa 2218381 ggaatcgtaa ccacctcttt ttatgcgatc tcttgatgga gaaaacaggc cagaaacaaa 2218441 atccttcgtt tttgacctgc cctcttcaca cgcaaagaat gctaccttct ttgctccact 2218501 gatccgtgaa gactttccgt tttaggcctg cttttgagct ttgcctcatt ttcacgcaat 2218561 ttcccatcat aatctttaat ttttgtgtct aatctcttaa ttgtttcatc aatttctttc 2218621 cgcttctcta tcagccgctg tcgttcgtca gccaggatat tttttcgagc ttctaccgta 2218681 cggtcacctt cggtaaataa tgttgtatat tcaattagcg cttctatcga tagtcccgca 2218741 tttcgcatgc atttaatgaa ttcaatccat ttgatatctt cttcatcata gtcgcgaatg 2218801 ccgctgtctt ttcgttttac aggcgggatt aatcctacac gttcgtaata tcggagtgtt 2218861 gcggctgtca ggccaaactg ctttgccacc tgagcaatat tcatgatctt cacctctcta 2218921 tcctgtatgt tgtgaaggta acacttaaag ttaactttaa gtcaagctca aaacaagtgg 2218981 ttagctgctg aatctgggtt tatatattcg ggacttgcct taaagcacac tttaaactct 2219041 atacttctcc atgcactaaa aacagtgtag ttggagggat tgctgaatgg caaataaaca 2219101 cactgccgga agagaacaat taggagaatt tgcgccaaag tttgctgaac ttcatgatga 2219161 tgttctattc ggtgacattt gggcaagaga agaagaactt tcatcccggg atcgcagcat 2219221 gattacagtt tctgcattaa ttactgactg tttctcagct tataaatcag gttcatttta 2219281 aatggttttt ttaaaaaacc cttgccttaa agcagacttt aaggtttatc gttatgttga 2219341 agacaccata aaacataaat aagtgcatgt ttttatttac aacacttatg atgaagaaag 2219401 gataggttcg tatgtgtaat caacatcaaa cccgtgtatt aagcgtgtca catgcaaaag 2219461 ccaaatttga acaaacgacg attgagcgaa gaggattacg gccgcacgat gtcttaatcg 2219521 atattaaatt cagcggcatt tgccattcag acattcatag cgcttttgat gaatggggcg 2219581 gtggcatctt cccaatggtg cctggacatg aaatagccgg tgttgtaaca gccgttggaa 2219641 caaaagtcac caagttggct gtcggggacc gcgttggtgt cggctgtttt gttgactctt 2219701 gcggagaatg cgaatactgt ctcaacgcag aggaacaatt ctgcacgaag ggtgttgttc 2219761 aaacgtataa ctcagtagac tacgacggaa accccactta tggcgggtac agccaaaaaa 2219821 tcgttgtcac tgacagattt gttgttcgca taccagatcg tttggaaatg gatgttgcca 2219881 gtccgctgtt gtgtgcaggt atcacaacgt attccccgct gaaacactgg aatgttggcc 2219941 ctggtaaaaa ggttgcgatt gtaggcgtag gtggccttgg acatttggca attcaatttg 2220001 cacatgcgat gggtgcagaa gtaaccgtcc tgagccgttc catgaataag aaagaggaag 2220061 ctctggaact cggtgcaaat cattactttg caacaagtga cccagccaca ttcactgcat 2220121 tggccgggcg ttttgacgtg atcttaaata cggtatcggc aaatctcgat gtagatgcct 2220181 atttatcaat gcttcgtata gacgggacac ttgtaagcgt tggagctcct gccaagccgg 2220241 acacatacag tgtgttttcc ctaatcatgg ggcgccgcag cattgcaggt tctctagtcg 2220301 gcggaattca agaaactcaa gagatgctgg atttcgcagc tgagcatggc atcgaaccta 2220361 aaatcgaagt catcggagct gaccaagtgg acgaggcata cgaacgtatc ctccgaagcg 2220421 atgtccgtta tcgatttgtg attgatattt ccacattgta ataggttagt ccttatatgg 2220481 gctgccgctt ttattgaaac tcacgaaaaa tgatctcttt aagcaaatat tttgaaggcc 2220541 ggtcaatctt cctgttattc tatgaataga gagttattag gagggttttt tatgagcaaa 2220601 aaaattgcag ttcttgttac agaccaattc gaagacatcg aatatacaag tccggtaaaa 2220661 gcatacgaag aagctggcta cagtgttgtg gctatcgatt tggaagccgg caaagaagtt 2220721 accggtaagc atggcgagaa agtaaagatt gacaaagcca tctctgatgt ggatgcaagt 2220781 gactttgatg cacttttaat tcctggggga ttctctccgg atttgcttcg tgcagatgac 2220841 cgtccgggtg aattcgcaaa agcatttgtc gaaaacaaaa aacctgtttt cgcaatttgc 2220901 cacggcccgc aagtactgat tgatacggat cttctaaaag gcaaagatat cacaggctac 2220961 cgcagcatcc gcaaagattt aatcaatgcc ggtgcaaact acaaagatgc agaagtagtc 2221021 gtcagccaca acattgtcac aagcagaaca cctgatgatt tggaagcatt taaccgcgaa 2221081 tctttaaact tgttaaaata acaagaaggc acagactgtt cgggtctgtg ccttttttaa 2221141 aattaagact ccttcgttac attctgaaag acagcagtcg cgtcccacac attcaagcca 2221201 aattggcctt ctgaaaatac ggaatcatgt gcatcaatca caagacgatc atctaaatag 2221261 attttaaagc gatcgccctc ggcctctgtt ttcagatgat actttttatt aacgtctatc 2221321 ggtgttttgt attcagcaat gacagaagca gcaccgttct caaatttaaa gaatttcact 2221381 aggtcatgct tcgcatccac attggcaagg taaccgtttt tggcatcttt gtcagagcga 2221441 aacattagtg ctcctgcccc tcttccgttt ccatccttaa tggtgatatc agattcataa 2221501 gtgaagtctg acccggatgc tgaagacaag ataaaggaat cgccgtccga cctcccttgt 2221561 ttcccctcaa ttgtgtctgc ccacgtgcca tttacagtcg tccagccagt catattggac 2221621 ataaaaggtg tcgttcccca tacctttttt aaagggtgta tcgttaaaga ttttaccttt 2221681 acaccgccat ttgcagcata taattcaagc cctttgcttg atcggtctgg gagaataata 2221741 tccgttatga cctgctttcc gtcattccca aatacttcaa ccgaggagcg gtcaacaaaa 2221801 atgcgcaact taaccttccc atttaccggc ttcaacgggg ctgtttcttt tccggtgtta 2221861 aaggccggat taaaggtgtc gttgcctgac tcgctccggt caacgaacaa tttggcgttc 2221921 cttcggtcat agccgacctt cgtaaattga ttttcacctg ttcggacctt aaaaccaaat 2221981 tcagcagctg aaccagggct tactttaaat tctgcattta tttcataggc atctccagat 2222041 tgccccgcta acacattatg acttgcaggc gatatggtca gattcttcca cttcttagag 2222101 gttccgcgaa tggtttccag ctctttcacc ggtgtttgga ccactctaac cccttcggta 2222161 aacgctttca attttaactc tcttggaatg gacgttgcac ttctccatgg ggatgtcgga 2222221 acatcattcg catattgcca attgctcatc caccctaacc atagccggcg gctgtctgtg 2222281 gatggaatat cagaccagga tacagccgca taaaagtctc tgccgtaatc cgtccagaga 2222341 actttgtttg gcgggttttc atttttaaaa tgagttccat caaagtcccc tacaaaatat 2222401 tgcatgcctg atcctcccga gaccgctccg tttccgacac tgacctgcat gacccatttc 2222461 ttttgattcg gattgccgtc taccggaagc tcaaataaat ccgggcattc ccatactccc 2222521 ccgtggcttc cttgatcctg tccaaattca cttgcatacg tccactgctt cagatttttt 2222581 gatgtataaa tgaggattcg gtcaccggcc gcaagcacca tcacccactt tttttctttc 2222641 tcataccaaa agacttttgg atcgcgaaaa tcttttttac ccgggtttgg aatgacaggg 2222701 ttgccagcgt acttcgtcca tgttcttcct ttgtcgttgc tataggcaat actttgcact 2222761 tgatggcctt cccgatcctg tgtataaatg gccacaagcg gcttctcttt gcctgtttga 2222821 aaaccgcttg tgttattttt atctacaact gcgcttccag aaaagatcgt gcctttttca 2222881 tccggataca gcgcaacagg aaggtgttcc catgtaacca aatctttgct gacggcatgc 2222941 ccccaatgca tgggccccca ctgaagcccg tatggatggt attgatagaa caagtgatat 2223001 tccccagcat aatataccat tccgtttggg tcattcatcc agtttgcctc cggtgtgaag 2223061 tgatattgag gacggtaatc ctcatcatag tagcttgaat cggctgcatc tgccgaaaat 2223121 gccatagtca acagcagggt gaacatgatc atgacttgaa tcagtctctt tttcatttgt 2223181 tccttcgctc ctctcttcat gtttgaacac tttcaaaaga gactgctgcg caagctggtc 2223241 cgtttctggc aattctcctc tgtttcactg ttatccgaat gatttatata tgaaaagact 2223301 gctgcagttt ctctctcttt ccttcacaca ccttatgcta agaatccagc ccaatacccg 2223361 agaatcccga tgacaaagat gccgcaaata atgagaagtg gattcacccc tttgcgaagc 2223421 atccatgcca ccaataacgt taatccgaga ggcagcgccc ccggcataat gctatctagc 2223481 acgttttgta ccgtttgaac atctactttt ccgctttcat ccttaatcct ggatacaacg 2223541 attggaatgt tgatggtggt ccatttggac acgagagccc ccataacaaa taacccgaga 2223601 atcgaagcgc cctctgtaag cttttgaatg cgattccccg ctaaatcctg aagaatctcc 2223661 attcctttca catagccata ctttaatccg taatattttg tgcttaatct tatggcattc 2223721 agcaagaaaa agaatagcaa aggaccggca atgtttcctc ctaaagcaag ggaggctcct 2223781 agcgcagcta agacaggacg aatcgttccc caaaaaattg gatcgcctac gcccgctatt 2223841 ggtcccatca aaccgatttt cattccgctt atcgcttttc cgtcaattcc tttattgttc 2223901 gccatttctt cttccatggc tgccgtcacg ccaaatatag gcgctgtcag ccacggatgt 2223961 gtattaaacc attccaaatg ccgctgtaag gcttcgtttc ttttcgctcc gggaccgtac 2224021 aattttttga tcgccggtat catgacataa caatatccca ttgcctgcac acgttcgaag 2224081 ttaaaggaac cgagtaaaaa atttgaacga ataaacatgc tgaaaatttc tttcttcgtt 2224141 aatcgttttt ctttctccat tttttcttcc ccctcatcgt ttaggcatca agatcatcat 2224201 catcgtcatc ataaacagca acactgccac tgtctgatgc ggccgcgact gctccgtgag 2224261 cgctttgttt ttgcatcacc tgctggtata aaagcgccag acagagacca agggctccaa 2224321 atcccactaa gttaaaatcg gtaaacgccg ctaataagaa accaatatag aaaaatggct 2224381 ttaaataagg aatattcatc atattgatca ccatggcata cccgacaacc acaataatgc 2224441 ctccgcctat ttgcagtcct tttgtaatga catcaggaat atttcccagg aacgcctgaa 2224501 cagcgctgac actaattaaa gcaacaatca atgtaggaat catgacgcgc aaagcttgaa 2224561 acaccatcgc ggtaatatgc ataatttcaa ttccttttat atttcccgct tttgcatatt 2224621 gatcagcgcg gtggatgaaa aagacagtga tcgtccgaac aaaaatcgtc agcgcctgac 2224681 ccgcagctgc taaagcaaca gcgacagcaa tcccttcgcc aattccttga tcagcggtaa 2224741 taactaaaat ggttgagatg acagaggcga tcgctgtatc aggtgccatg gcaagcccga 2224801 cgttcatcca gccgagcgcc atcagctcca gtgtgcctcc aagaataatt cccgttttta 2224861 agtccccgag caccaagcca accaacgtac aggccactag cggccggtgt gtctgccctt 2224921 catccaatac acttgcgatt ccggtgattg ctgcaatgat taacaacaaa ataatttgta 2224981 atgaagacat attctcatcc ccttgattat tttgttacgt tccgtaaaat ctgtacaaaa 2225041 tcctcactgg catctgaagg cagctgcctc aattccagtt tcacgccctt gtcacttaat 2225101 gtttcaaatg cctttatatc ttgttctgtg acactgactg attttgtgat ttgcctgcga 2225161 tgattttcaa aacgcattcc cccgacgttt acggttttga tcggtacacc tgcttctata 2225221 agagatacaa tatcggacgg attttcaaac aagagcattg ccgttacccc ttcgtagcgc 2225281 ggactatgaa atgcttttgc cattttagaa accgagacgg cactcgcctt tacatttgaa 2225341 ggcgcaacag aaaggatcag cgtttttctc atttcgtcct gagcaatatc gtcggagaca 2225401 acgatgattc ggtcggctgc atggactttt atccaccttg tcaggatttg gccgtgaata 2225461 aagcggtcat caattcttgc taacacaatg ttcatcataa ttcatcctct cttgtatctt 2225521 gattggctgt ttttactttt tctaaatgtt cactgcacac ttgaaagctt tgctgactca 2225581 ttgcttttaa gttgttcagc aaatctttga gagccagatg ttctctcagg cttaatacct 2225641 ccagcagaat cggcaggttt acgccggcag ccatatccat tctttgatcc tcagcaataa 2225701 aggaagctgc cgcgttatat ggcgtccctc caaaaatatc gactaaaaaa agcacttcat 2225761 gttcttccgg gatatccttg agcgcctgat gatatttttc ttgcagcgtt tgtattcctt 2225821 cccctttgaa aaacggcact gcaatcaggt tattttcttc accgaatatc atccctgaag 2225881 actcttttaa tgctatggga aaatctccat gaccgctgat aataactgaa atcatatcta 2225941 ttgctccttt cctgttttgt acatccatat ataatgcaag gatcgtgcca acacagttgt 2226001 gttaagcgtt ttcattgtta tttcagccaa tagcaatttg ttgttgaaac acttaaaacg 2226061 aaaaaaataa acctgtatta aaatggtgtt ccatttaata caggttcata tgaaaaaact 2226121 gtttttaaaa cagctggcca tgcacttctt cagcaaatat ggcggctata aataattttt 2226181 catcatcact tatgcgaagt ccgagctttt cttcataagg ggctaatgtt cgctctgtca 2226241 cgtacaccat ttccttcagc tgatcattga tctcttcttc ctctgagaaa gcgatcggat 2226301 tctgcttaat taccctttca aaggcgaaag ccgtgtgcat aatgactttg atcaaaaccg 2226361 cattattgaa aatgaccccc agctcatcct gaacggtttg cagccactcc aataacatgt 2226421 cgatcacatg gtggggattc aagaagacaa ggtatttttt caggctatcc tcgcaaagct 2226481 ccctgacaat aatatttgct tcgttcaatc cattgctcaa ggagatgctt ccttttgtaa 2226541 tcgcctgttg aatcagcttc tctccctccc cttcaattaa cacttctaaa gatacatgcg 2226601 gagcattgat tttagggtct ttcgttccga ctgtcgcaag gatttcatac tctttttcga 2226661 tttcttttat gctgttggcc agcttaatcg atgatacggt caatatgtga atgggggtat 2226721 cggaggcctt gtttacgatc gtggttagaa tgtcttccag ctttttggcc gttccgctac 2226781 ccgtcgtgca gatggatacc aatgccttct ttttgccgga tgccgctggc tgacgctccc 2226841 acaactcgat aaaatccttc gtgaccgatt gatagatcgc atgcaaattt aaattcaaat 2226901 agttgacctt tctgacagca tccagcacca ttgaagtcgt aacattgctg atcgttttaa 2226961 tagaaatgcc tgtcttttcc tccagcctgc tttccagcat tgcaagcgac cccatatcta 2227021 ccagcattaa aacaccttca ccttcatcaa cctgtttcat tttttctgct acgcattcaa 2227081 gaatgtccga aggtgaaaca gtaagcggca tgtcaactgc tgcaatcggc gtactcccta 2227141 gcagttctgt cgcgacttca accattgaac tcgccgtgct gtttccatga gctgccacga 2227201 taataccgac tcttttgttc tcctttaacg atttgatgga atgaattaac atcgttaagt 2227261 agatgacttc tatttcagga atagccactt taaaatattc ctgaatttta tctttaaaaa 2227321 tcatcgccac ccgatattct ttcacatggg tatcacgaat ttcatctgtc tcctgtgtat 2227381 tcaaaacatc aatttgcttt cctcgcttta aaaatgcgtc aatatgcata ctcaagaaat 2227441 aaataaactt acggtcaaat gtgcaatcca gctcatgttc agctatttct tttaactgtt 2227501 ttgtcatttg aatcacatcg tcttcaacga atgtcagcag gttgtctttt tgaaaagctt 2227561 gatgatgaaa aaaacttctg acatgcaaat ggacatcagt caagatgtac tggttaatat 2227621 cctttttgga taaaccttct ttcataagcg ttttcacttt ttcctcaatc aaatgatata 2227681 agttaaatga gaggtcttcg tcaatttttg ttgtttcatc ttctacaatc ggagagataa 2227741 tcgttgtaat attgacatat tcagaaatgg ctttgcttct ttgcatgttt ttgctgctgg 2227801 acatccattc ttgcttgatt tcatcaggca gatcgcgaac agtcagttca ataacttcat 2227861 ttctgtcaag gttatgcaaa aatccgtgtg cgcaaactaa ctgaacattt gatttcagct 2227921 gtccgacatt cccaaatttc gcagagtgaa taagcgcatt atagacatcg atatgcacac 2227981 tcagattctt cttaattcgc tctgcttctt tccctaataa aaacgtcgtc agatccactc 2228041 tttcattaag cgatcgttct tcaagcgaag gaatatgaat ggtcattggg attcttcgca 2228101 aaaacgtttt caatagtgca gaactcggat tttctgtagt cgcacaaata aacaatacgt 2228161 tcgatgttcg tttatgttca gattctccaa gcctgttata agaaccgctg tcaataaaat 2228221 aaaacagcat ttcttgtccc tcgggaggga gacggtggat ttcatccata aaaagaatgc 2228281 ccccattggc ctgttcgact aaacccgcct tatcctcggc agcacctgta aatgaacctt 2228341 ttttgtgtcc gaataattga gaaagcaata attgagggtt gttgtagtag tctgcacagt 2228401 taaatgtaat aaatggtgcg ccggccttca atatgtcaga gtaaatggca aactggtaaa 2228461 ttcggttcgc aaaaagggat ttaccggaac cagtcggccc taggaggagc atatgcagac 2228521 cgttcggcgg ataaaagaca gctgcttttg cctgggagat cgctttcttc aaactccctt 2228581 ttgcccctat cataagctct aggggattcg tggaaatgtg ttgatgattt tgctttgaat 2228641 ttccggaaaa cgcctgaagg tctttcactt ccatcatctc tgtatcccat ttcttgttga 2228701 ataatttttc tgctatctcg actgggatgt atcttacagg aaatgtttta attttgatga 2228761 cctttttgga ccggacgaga ttgttcaatt caaagctgac attggaccgc tccattttca 2228821 gctgctcggc aatctccttt gctgaattcc cttgtatttt taaaagatga tctaaggttg 2228881 aatcatgaaa attatgcttg agctgatggt atattttatc tattcttctc acgtctatca 2228941 tcctttgtcc ttattagata agccattaac aagaatattt cgaaacttta tagtccgcgt 2229001 tgagatttac acgtttaaaa aggtctctat agcagattga caaagctggc ttttatgcgt 2229061 atatgtttac atgttgaatc atttgcacct catattagta tgatagatgc tcagttctgg 2229121 agggccagtc cccttcaaaa gtaataatca gtaaacagtt tatcattctc ggggaatgta 2229181 atgatgtcaa aataatcaat gacaaaaaat gaatcttata gatcatgaca aattacccaa 2229241 atataacccc ttaagttcgt tcacaactaa aaagacggac actctatgtg accgccacag 2229301 tattacaatt tgcaaaactt cgtcattttt gcaatccaca ttggaggtta aggaatctgt 2229361 aagcttaaaa actttatctc cgatcctatc gatttgatcc ccctgccggc ctcaatcata 2229421 gtgggtatgc aattatacaa atcgttaccg attaaaacta gcctgtcaga ttgtccaaat 2229481 gactttcctg ttttactctg ctattcaggt agaatcacga gtgaaaaata gagccacaag 2229541 acatgtaaca gcacttaaaa tagttttaaa atttaaaaat aaaagtatct attcttttaa 2229601 atgttataat atccgataaa actttactca tctttttatt actggaggaa aataaaattg 2229661 ataggcaatt ctagcaaaga caattttggc cagcaacaga aattgtctag aggccttaaa 2229721 aacaggcata tacaattaat ggcgattgga ggtgcaatcg gtacaggttt atttttaggt 2229781 tcaggtaaat ccatccattt tgcaggacca tccattttat ttgcttactt gatcaccggc 2229841 gtattttgct ttttcattat gcgttcgctc ggagaactgc tcttatcaaa tgcgggatac 2229901 cactcttttg ttgattttgt aagggactat ttaggaaaca tggcagcatt tatcactggg 2229961 tggacctact ggttctgttg gatttccctc gcgatggctg atttaacggc ggtcggcatt 2230021 tatacgcaat attggcttcc cgatgtgcct caatggctgc cgggtcttct tgcgcttatt 2230081 atcctgctga tcatgaacct tgccaccgtt aaacttttcg gagaattaga attttggttt 2230141 gcattgatca aagtcattgc catactggct ctgatcgtaa ctggtattct cctgattgcg 2230201 aaaggttttt ccgcagcttc cggccctgcc agcctcaaca acctttggag ccacggcggc 2230261 atgttcccaa atggatggca tgggtttatc ctatctttcc aaatggtcgt cttcgctttc 2230321 gtgggtattg aacttgttgg actgacagca ggtgaaacag aaaatcccca aaaagtgatc 2230381 cctaaagcca tcaatcaaat tcctgtccgg attttacttt tttatgttgg cgcacttttc 2230441 gtgattatgt gtatctatcc ttggaatgtg ttgaatccaa acgaaagccc atttgttcag 2230501 gtcttctctg cagtaggcat cgttgtggct gccagtttga tcaattttgt tgtattaaca 2230561 tcagccgcat cagctgcaaa tagcgcttta ttcagcacaa gccgaatggt ctattcactt 2230621 gcaaaggatc atcacgcacc tggactatta aagaaattaa cttcttctaa cgtgccaagc 2230681 aatgcgctgt tcttttcatc catcgccatt ctgattggcg ttagtctgaa ttatttaatg 2230741 cccgagcaag tcttcacgct gattacaagt gtttcaacaa tatgcttcat ttttatttgg 2230801 ggcatcacgg tgatttgcca tttgaaatat cgaaaaacaa ggcagcatga agcgaaagca 2230861 aacaaattta aaatgccttt ttacccatta tccaactatt taacacttgc atttctcgcg 2230921 ttcattcttg tcatattggc actggcgaat gatacacgta ttgctttgtt tgtcaccccg 2230981 gtctggtttg ttttattgat tattttgtat aaggtgcaaa cccgcagagg acataaggtg 2231041 aaataaaaaa aagacaaggg atactcactc ccttgtcttt ttatatgtgt caaacactaa 2231101 attaaacttt ggtttcaaat ttcattcact tcatttaagt gttaactcaa accagttttg 2231161 atgccgaaac ctactaatat tattccggta attttttgaa acactttctg gaacttcgag 2231221 tttttcatcc atttttttgc gtaatcaata atataaacaa gaaacaggaa ccacaacacc 2231281 gctaataagg ttaggattga agctaaaatg atgagctgct ggtttatatt tccgttcaaa 2231341 ttgataaatt ggggcatgat tgtaacatac accaaaacag ttttaggatt gagaatgtta 2231401 ctgagtgatc cctgcataaa ggaagtttta taataacgtt tcggagaact tgccatattt 2231461 tttgcttggg attgcatgtc atctaacgaa aacatacttt tagcaaaaaa actttttaca 2231521 cctaaataaa ttaagtatgc cgctcccaaa tatttgatcg ttgtgaaaag aatcactgac 2231581 tttgcgatta ccactgataa tcctaaaatg gcaatcaccg tccaaaagga aagtcctgtc 2231641 gccaatccga gaatgttata acggccggct ttcggaccat acctaagcgt atttttcatc 2231701 acaagcatcg tatctgcccc cggtatgata accatcatgg cagcgatcgg tatgtatgcg 2231761 agtaagctgt gcattgttct ctcccccttt aaaaatcccc tcaatcatat agtgactaca 2231821 aaagtaacta cttataaaag tgtatcaatg cgtttggaat aaatcaatat gatttgttaa 2231881 aatagcgatt actaaggcag cgattgctct ttatattgga ggatatatga aagaaaatat 2231941 gttagacatt ttaaaaaacc tcaattttac agaatatgaa tcgaaagcgt atttagcatt 2232001 attgcaagaa tcacctttaa caggctatgc cgttgccaaa aaatccggag tgccccgttc 2232061 taaaatttat gaagtattgg aaagtcttgt cataagggga gatgtttttg tcagtcatgg 2232121 aaatacgcct cagtatgttc cagtccccgc aaaagaactg attaaaaacc gccggctcaa 2232181 agcggaagag cattttgatc aggctgagaa atattttgaa aagttcgagc agaccgcaaa 2232241 tgaccgggaa aacatctgga atatcaccgg ccgcagtgaa attcttgaaa aggtgaaggc 2232301 ttgtatctta tctgccaaaa aaagaatcct cttagaaata tggaaagagg attttaagga 2232361 gatagaagca gagctcaaac aggcggcaga acaaggcgtt attgtcacca ttattgcgta 2232421 cggagacatc gtatctgatt ttgccaatgt ttaccttcat gatatgagca gtgaaattac 2232481 agaagagtat gacggacggt ggcttgtcta tagcggagat gattcagaag tagtagcggg 2232541 cattgtctca cttggcaacg acagccgtgc tgcatggacg atgcatgtag ggttagtcat 2232601 gcctattact gaagtgatca ttcatgatct gtacctcatg gaaattctga aaaagcatag 2232661 agagctttta gaagagagct tcgggaaaaa tctcatccag ttgcgccgta aattttctat 2232721 tcactcagat ttcaaaaaac attatttgga ataatgtttg tcatctctta ccccaaaaac 2232781 aaggcttgta caaaacaagc cttgtttttt tatgcataaa ccccccatgc tgatttactt 2232841 ctctctttta aaaaatgtga ttctgcgcaa actatttttc agcctgccgc gtctatccta 2232901 ggtaacagcc tacgatatac gtatattcaa aaaggagccc tttattgcaa tgaagaaaaa 2232961 acaaacaaca aaagcgttgc ttgtcacatg cataactgac cataagcaag atttctacag 2233021 gttggctttc agttatgtga aaaatcaaga tgacgcatta gatattgttc aggaatctat 2233081 aaaaaaagcg ctgagctcag ttgaaacggt caggaaccct gagacgataa aaagctggtt 2233141 ttataaaatt ttagtacgga cagccattga ctttttgcgc aaacaaaaaa agataagagt 2233201 gatggacgac gaaacgatag aatttttaag caaaggaaag gaagaccatt acaaggatac 2233261 tgatctccat gaagcgcttg acgaattgcc gtaccgctat aaaaccatta ttattttacg 2233321 tttttttgaa gacctcaaat tagaagaaat tgcggaaatt acaggagaaa acacgaatac 2233381 cgtcaaaacg cgcctataca gagcattgaa gctgatgcgc attcagttga cgaaggagga 2233441 tctttcttaa tggataagag attacagcaa ttaagagaag aatataaaaa tgttcagatt 2233501 cctaaagaat tggatatcat tgttgaaaaa gcccttcagc aagaaccaaa aaagaaaaga 2233561 atcgttatgt ggccgacatc agcagcaatc gctgcagcta ttttattcac tgcgcttgtt 2233621 aatatcaacc cggacgccgc tcaggctatg tcaaagatcc ctgtcatcgg caaaatcgtc 2233681 aaagcgatca cctttattga aatcaaagag gaaaaagacc aatcaagcat tgatgtcaaa 2233741 acacctgctt tgtccgggct ttctaataaa gagcttgaaa acagcattaa cgagaaatac 2233801 ttgaaagaaa gccagcagct gtataaagag tttatacagt ccacatccaa aaacaaaaaa 2233861 gggcatctca gcatctacag tgattacgag acggtcacag acacgccaga tttactctct 2233921 atccggcgca atattgaaac aacacaagca tcttcctaca cacaaagccg ttatattaca 2233981 attgacaaaa agaatgatat tttacttaca ttaaaaagct tattcaaaga tgagcgctat 2234041 atcaaagtca tcagtcaaaa catcaaagaa caaatgaaac agcaaatgaa ggaagatcca 2234101 aataaaatat attggctcac tgacgaagat gcagaaccgt tcaaaacgat tcttcctgat 2234161 cagacgtttt acattactga agaccataaa cttgtgatct catttgacga atatgaagtc 2234221 gcccccggct atatgggcgt tacagagttt acaattccaa ccggcgtcat ttcaaacttg 2234281 ctcgtgggag aacgttatat tcgataaaat aaaaacatcc atctaagatt atggatgttt 2234341 tctctcttct ctattcgagg tcgtaacccc gctatcaaaa acaacgagaa tatttgcata 2234401 ctattggagg aatacccatg tatcacaaga cacagcatca tcgatacatt cctggacttg 2234461 atggccttcg ggctttcgcc gtcctgtcag ttatcactta tcacctaaat ttcaattggg 2234521 ctaacggtgg ttttatcggg gttgatatct tttttgtttt atccggatat ttgattacat 2234581 ctattctatt accggcatat ggaaatgata tcaatcttga ttttcgggat ttttgggtgc 2234641 gccgcattcg gcggcttctc ccggcagcgt accttatgat cttttccact gttgtgtggg 2234701 tcgtattgtt tgatcgagaa ctattgcaca ctgtacgtgg agatgcgatc tcttctctct 2234761 tttatatgag caattggtgg tttatttttc acaagctatc atattttgat agtttcggtt 2234821 ccccatcacc tctaaaaaac ctttggtcgc tggcgattga agaacaattt tatatcatat 2234881 ggccgatgtt tttagttgtt ggaatgtaca taatgaaaag ccgcgccaga ttggctgcgg 2234941 tgatatcatt gcttgtgctt tgttcagccg tgatgatgag cgtactgtat gaacctggcg 2235001 gagatccgag ccgcgtttac tatggcacag acactcgttc gtttgaactt ctcatcggat 2235061 gtgccttggc tttggtatgg ccgatgaaaa ggctgtcttc caacaggctg ccaagcaaac 2235121 tgaagcacac tttgcacgcc actgaatttt tggcattttg tattttagtg ttgtgtgtct 2235181 atttcacaga tgaatacgag ccttttcttt acagaggcgg aatgctattc attagcgtga 2235241 ctgccgcaat ccttattgca tgtgtttgcc atccgagcag ctttttaggc aatctgcttt 2235301 catggaggcc gcttcggtgg cttggaacga ggtcttacgg aatttatctt tggcactacc 2235361 ctgttattgt gttaagcacg ccagttcaag aaatcggaaa ccctgttttt tggcatatcg 2235421 tgctaaaggt cattgtgaca tgtatacttg ccgagctctc ctaccatttt attgagaagc 2235481 cgatacggac acagggattt aggtcatttt cccgccgtgt ttttatacat agaatcaagg 2235541 aatggaaaac gacatctgtc atcagcaaaa tgtcaattgg tttcattatt ttcgctatac 2235601 ttatttttgc aggcgggctg tcagggctag ccggcgagca aaagcaccct accaaatgga 2235661 cctatagctc acaagaaaca aatgctgaca ccagccaggc ttctggggat aaaaagaacg 2235721 ctgcagcaga taaaaaacac aatcctgaac aaaagacaac agattccaat cagggtcaaa 2235781 aggaaaacaa agatagtggg caagagactc ataaaaagaa agacacgcaa tcccaacagt 2235841 tgaaaaaacc agcagacact gcgaaagaag ttttagctat aggagattcc gtcatgcttg 2235901 atatttcttc acacctgcgt cagtcatttt caaatgtgac gattgatgga aaggtaggga 2235961 gacaaatgtc tcaagctttg gaactcgcaa gggaatacaa gtcttttaat cagccgaaca 2236021 aggctgtcat cattgagctt ggaaccaatg gctattttac aaacagccaa atcgaacaac 2236081 tgcttcaatc tttctcaaaa gctcatattt atcttgtcaa tacacgggtt ccccgccaat 2236141 gggaaagcaa ggtaaatgaa tctttgcagc aacaggccca cgcacatcaa aatgttacgt 2236201 tagttgactg gcatacagaa gctcttcagc atccggaata ttttacccct gatggtgttc 2236261 acttggttcc taaaggggca aaaactttga ctgctcttat tgttcaggcg atgaaatcgt 2236321 aaaaaagaga tcctatacag atcacttttt tactttagtt tctgatcgtt gattatgtct 2236381 tctttcagca aggcagccct tatgtttaca tgccgtttac gtaagggtaa gccaaaattg 2236441 aatggaggga tgataatgaa aggaaatgaa gaacatgaca tccaaaaaga gttgaaacga 2236501 tatgagcttt ttttcaaaaa acgatataag gttctttata cagtaaacga ttttatcatc 2236561 ggtgctatgt ttctcgttgg aagttttttc tttttttatg accggttaat gtcggcaggg 2236621 atatggctgt ttgcgatcgg aagtttgctg ctgttaatca ggccgaccat tcggctgatt 2236681 catgactttc attaccgtaa gcatgtggaa cagcaattca agcatcaatc ttcaacagat 2236741 gactgatctt aaggaataag aaagaacaaa atgccaaaag cctgagtcga aaatcaaaaa 2236801 caagactttc agactattta tttttaaaaa caaggtaaaa agaactaaac ttttgcctct 2236861 gcatgccgat atgaataata aggccggcgc gatactccct ataacatcct tttcagtaga 2236921 tttcattatc gtgccggttt tctcatatgc aaagcaatcc cgccaatcag attggcggga 2236981 ttttatattt tacattcctg tccaaacgtc tttcacataa cgtctttgat cttgcagctt 2237041 ttgcagccat acagctgatt cttcctgact tgctgctttt tcagcttcat atgccaatcg 2237101 caaagttctc tctacatcag gagccatttg cgatccatca ccgcatacgt aaatatgagc 2237161 ccctttttca atgagtgtca tcaatttctg cgtatcttgc ttgagcaagt gctggacata 2237221 tccttttggt tcgttttcga cgcgcgagta gcatcggcgg attgtgacca aaccgtcctg 2237281 ttccgcttga tccagctctt ctctgtaaag gtcgtcatgg tccgggcggc ggcagccgaa 2237341 gtataaaagt gcttcaccaa gggtgcttcc ttccttcttc aaaaccgatc ttgcctgaat 2237401 aaagcctctg aatggcgcaa ttcctgtgcc cggcccgacc ataatcatag gcgtttcagg 2237461 atcattcggc atctgaaatc cggactgcgg cgtacgaatg aagcaagctg ctgcatcacc 2237521 tgtattcaat tctgctaaat aattagaggc gacaccccgg tattcacctc ggccgctcca 2237581 tgctgaggct ttcacaactc ctaccgtcat gctcacgata tttgcatgaa ctttcggtga 2237641 gcttgaaatg gaatagtatc tcggttttag tgatggcaaa agtgctaaaa accgttcaaa 2237701 cggcatttcg caagcaggat aatcctctaa aaaatcaagc atggtaagac gttttgcaag 2237761 tacctgctct ttgtaaatgc catcatctga aacgagctgt tccagctctt tttgatgcgg 2237821 cggacaaact gtataagagg ccagctcccg aagctgaagc cttgatgccg gttcctgcag 2237881 ctctacatag gacgacaata aatccactac tttgattggc cgatccatcg gcagatgagc 2237941 catatgagcg cttccgctta cttttatcac atgattggac tgcaaaccga atcggctgag 2238001 aacccgctga acaagctccc tgctgttctt tggcaggatt ccgatatgat cgccttcttt 2238061 atatgtttta ccagccggaa tttccaattc aatatggcgg gttgaacgcg tgctggcagc 2238121 tgtctggagt tctcgattct ctaacacaat cccttcaaac gcgccatatg ctttagcaac 2238181 cggcgtttcc gtcgcttcac tgagaaaagt aatcgataat gaaggcctgt cttctttctg 2238241 ggctatttcg ttaatatcaa atgcgtccat cgtttccttc cagaagcggt tttcccaaga 2238301 ctcgcggtgg ctttcaaaat catcggcggc gtcaccttcc ccaatcgctg ttaaacgcga 2238361 tgcccccttt gctttcatca tgtcatcaat caggcgggga atccgctgat acgtgctggc 2238421 ccagctccgg tttccgcagc cgaataccgc ataggaaaca cctttcaatt ggccttcctc 2238481 aagctctttc agccactcta caaatccggc agcattatca ggcggcgccc cattataaga 2238541 agccgttaca atgacgactg ccccttcttc agggagcttg ccgatataat catcaagcgg 2238601 agccgtttca gctgtaaagc ccatctggcg gccttgagca gccagttcac cggctattcc 2238661 ctcagctgtc ccaagatttg aaccaaaaag aacaagtaaa ggtgtgccgt gtttaggttt 2238721 ggtttctttt ggctttgttt ctgctttgat gtctgcctgt tcttttctct gtacattgat 2238781 tgccgctgtt tttcgcggtt tcacagtaat tttaaaatca tccggcttga tcgttaatgc 2238841 ttctttgatt tttagttcgt agccagtatg gtttatcaat tcaaaatgct ttaatacaag 2238901 accgagaacc attgtcgctt cttgaagagc aaactgcatg ccaatacaag cgcgctgtcc 2238961 gtttccaaac ggcttatacg catggtgagg gatacttgaa ggatcctcaa accgttccgg 2239021 acggaaatct tccgcatccg gtccccaagc gttttgatcc cggtgcagtt ttggaattaa 2239081 aacagtgact ggctgccctt tgctgatcgg atattccccg cctagaacag tatcctcctt 2239141 cgcatataga gaaaaagccg gagctgttgg atacagtctg agggtttcat ttaaaaccat 2239201 ccgaatgtat ttgagctgct ggatttgttt atattcaggc gtgtcatccg ttaacacgcg 2239261 atccgcttcc tcctgagctt ttttcagttt ttccggatgt gtaagcagac aataaatcgc 2239321 aaaggatagc aacccgcttg ttgtctcatg tccagcaatt aaaaatgtga tgatttggta 2239381 tcgaatgttt tcgtcatcca gcgtttcacc cgttactgga tctttggcat aaagcatgag 2239441 agacaagaga tccttaatgt tttcatccgg attcgccttt cgctccgcta tcattctatc 2239501 aaccagggag ttcatgactt ctatatcctt ttggaactgc agcttcgttt tcaccatcat 2239561 tttatcttgc aggcccagtc ttttcgattg attcatcgcc tcttttaagg cacggagcat 2239621 actggtgata aacggatgct gtgaatcacg gtaaaagctg ttgaatcgat agttaaaccc 2239681 gcataaccca atcgtatcaa gcgtcagacg tgtcatatcg tccgctacat caatttcttc 2239741 attagggttt aaccggctcc acttttgaat cagctgggtt gcgatatcca gcatcataga 2239801 atgatagcct ttcatcgctt tttgactaaa actcggcagc aaaatgcggt gggctttttg 2239861 ccagttcggt tcgtgcgtcc agcttgtaaa taagccatct cccccgaact cacgcacctt 2239921 ttgcaagcct ttgccaaggt tcttgtcaaa gcgtttttca tcacacactt cagccacaag 2239981 attgtggccg gacacaaaaa cactggatac tcccggaaaa tcaaaacgga aaatcggtcc 2240041 caattcatca gctatccgcc ataaggattg agaaagctgt tctttttcca gatgcggaag 2240101 attttttaaa ggtccgtatg ttttgggctg aggtattgcg cttgcctgtt tcattaacat 2240161 ctccctttcc tatttttgtg atgaatgaag cttaatggcg tcccagcagc attgttccaa 2240221 ttcagtaatt aaatcagtgt ccatctctat atcacctgtt tgaacgagct gatatatctt 2240281 gagaaacgcc cctaatacaa tcgcaattaa cacattagag ggcaggctgc gaatcacgcc 2240341 ttccgctttt cccttattaa aatagtcatc aagcatttga gtcagatttt ctatcatttt 2240401 tttgcttgta tgatttaagt aatgagcgtc ttttttggtt tcaagaaaaa aaagcgcata 2240461 gtcgctctct ttcgtaaact gaacgagaca gcaaaatacg tggtgaaagc cttctctgac 2240521 aggcaattct gaaacgtctt gcttcagttt ttccgtaaat cgctggatgc tttcttgaaa 2240581 cagtacgtta acgagtgttt ctttgctgtc aaaataacga tagatcgttc ctgtccctac 2240641 atgagcacgt tcagctatca taggaatagt ggtagcgtca aaaccccttt ccgtaaaaag 2240701 tgagactgac gctttcataa tcatgtcgta tttactgctg gatgcggata tcatgtaatc 2240761 tgacaacctc cgattcgttt acggaatgaa tattcattcc ttttgttcac aaagaatgtc 2240821 tgccctgtct gatatcacct ctttgttctt tcttctgtta taagtttata tgaaaaaaac 2240881 tttttttaat ataaagtata tgcaaaaaat aaaaaattaa gaaaatatac ccaaatccta 2240941 atacgaggat cttggatata tttcccgaga aattttttat ttaacagcca caatacatag 2241001 acaggaagca cgcctgataa cagaaagatc cctgaaatgc tggtctttca gcagttgaat 2241061 atacgttttc tctttttcac cggtatttgt gtcaatactg atataaaacc ggccgtcaat 2241121 ttgaagcacc ctgtaaattt ctcttaatgc aagcctaata tcggtgcagc tttgaaccgt 2241181 atgtaaagaa aagactttat taaaggtacg gtcatcaaag ggaatgtcct ctggatagcc 2241241 atgaaaaacc tccccgttcc ccatgttctt tcgattcgca cgtgatatct gtcttacctt 2241301 tcgttttgaa ggatcaatgc tttttaggct accctttttt agtttcttgg ttatgctttt 2241361 aaagacagtg ccgtttccaa ttccaatttc taaaattctg tcattttctt gtatatctat 2241421 agagtcaatc atcatatgct caattgtttt ggttagctta tatttccgag aaaataattt 2241481 ccaaaaatcc gatcgtttat agagtctatt ttctagcatt ttaaacacct gcttttggtt 2241541 tcctatgttt atttattatc ttaaaaaaat aaacatcatc ttcatttcta aaagtgaagg 2241601 aaggtaccaa ctagacggca atgtattgaa aaatgtttca atagaactaa actttttcat 2241661 ttttttccga aaaaaaagca gaaaacataa tgttttctgc cctctttcta atgccaatga 2241721 taagggaata catacagcct ttgctgctgc attgccatca gcctctgctg tcggaatgga 2241781 tttccataac catgtttgaa ggaatgcggc atggacgcat aaccatggcc aatcgacggc 2241841 agtctttttt gataatcgtt catcatgcca tcacctgcct cacaataacg ttgatttact 2241901 atatgcaggc gcgcattttc ttgacagcta tttcgctaaa cttggtcctt ctccattgta 2241961 taatgcatca atagttccat tctaagcata tgccattccc ccttcagttt ttttcgttgc 2242021 ttttagcgcc agtttgttaa ataaagatgc tttaactgag actctttcat ttcatcataa 2242081 atttgttcaa tctgctgttc tcgttcgaat tcttccaggc ttttaaaccg ttttttaatc 2242141 gttaacgtta aaaagaatag gttaatcgtc atatcgctca ccccctttca aagtccgcat 2242201 caagcgaaat aacccgcggc acaacccttc tgccgcgggc aaataaaaac cgcagacaaa 2242261 agaagacacc aatgcctcta ctgcctgcgg ggagttgcgt atgtccgact attccgaatt 2242321 taatgcgtgc gataagcatc ggttaaggaa ggacacgaac tcttccacag gctgaataaa 2242381 ccatgaactt ttacatgtgt atcacgtaca ggttgacgtc gttgtctcat tgtcattttg 2242441 gttcagcctc ctttgctttt ttcttacttt gtaagtatat ccaccaaatt ccattttgta 2242501 aacatctttt tctaaaaatg gacggaaatt gtgcaaatca tcgaatggat ttgcccgttg 2242561 gtcatgacac ctgcttcatt tcttttctgg agcggtcttt cttatgatat gcaataaaat 2242621 aaatgagacc gacaaataca gctccgccga tgacattacc gataaaagcc ggaatgatgt 2242681 ttccgatgaa ctgcccccac gtgaatgagc ctgcaaaaat ggcagcagga atcacaaaca 2242741 tgttggcgac aacgtgctga aatccgatag ccacaaaagc catgattggg aaccagatgc 2242801 caaggatttt tcctgctgcg tcttgggcgc cgaaagaaag ccacactgca agacatacaa 2242861 gccagttaca gccgatggcg gaaatgagaa ccttgccaaa gctcatatca agctttcctt 2242921 gggcaacggc aatcgttttt tctaaataag gacctgtttc agtcaatcca accaaatgcc 2242981 cgaaaaagta agcaacaaac aatgcgccga ttaagttcat aattgtgacg attccccagt 2243041 taatcgctaa ctcttttact gatatttttc tcgaaaataa cgccatcgca actgacatca 2243101 tattgcctgt gatcagttca gcgccagcga gaacgacaag gatcaggccg actggaaata 2243161 ctgctgcacc aatcaaactg gacaggctcc cccattcttt cggaagatcg ccaattaccc 2243221 tgatatcaag caaataccca agcgcgataa atgcaccgcc taaaaacccc agcacaagca 2243281 gtgacggcag cgggagcttt atttttttca tccctgcttc aattgctgct tccgctattt 2243341 catccggttt tcgaaaagcc ataataaaac gcctccatta cttcttcttt tctcacagtt 2243401 atgcaagaaa ggcaataaaa aaggcagcac tcaaataacc tgtgtcaaac caggcgtttg 2243461 aatgctgcct aacttgtatg catacccata caacaatatc aagcagtata taagatattg 2243521 aaagagaata tatacagttc gtgcatacat tccattgctt tagccttcta taactgtagc 2243581 aacatcatat caaatgtgac aaatttgtgt caatgacaaa tatactagct ttgcagagct 2243641 tctttttgct catctatttt tcggtcaaaa acaaatacag atacagcgat gttttcctca 2243701 attttaatat cagaaaacaa atggactagc ttagctccca taagttcctc cattccttcc 2243761 ggtgtttgtt tggaataaag gtcttgaatt aggcttgtcc gggccgcatg taccatctct 2243821 cttccttcag gcgtgcgggc aataaactgc tcgcttgcac tcagatttcc gtatagtgtt 2243881 gaaactgcca tgttttctac aaatacagta tgaattctct caggcccttt tccgaacaat 2243941 tctttgcgaa gttttcgaat aatatcattg aattcatgaa tttttttaga catgctgatt 2244001 accccttccg atattgcctt ataaaggctt ttcccggttc ccctcaggac atttcacttg 2244061 gttaaaattt tcctgccata ttgtattata ataaatatca cattataata aaagcagtgt 2244121 tgatggattt gtaataggat cttgttatga gtctatcgtt ttataaaaat caaggattgg 2244181 tctgttagta agacttgcta gtgaactatt ccgccatgtg tgtttacacc ttcttagaat 2244241 taagggcagg tgtatctata catggctttt tttgacttct tgaaagaaag atggagggga 2244301 atatgaatat gatggacgtt aagtcgatca gtgtccgtgt agacggaaca gaaattcaag 2244361 cacgagcagg ggccacaatt ttagatattt taaatgaaaa cggaattgag tacccgcaga 2244421 tttgccacgt accagaggtt gacccgattc aaacttgtga tacttgcata gtagaggcaa 2244481 acggcaagct ggttcgttca tgcgcgacgg ttgcagaaaa cgggatgtct attgatcttt 2244541 caggaaatcg agtgaaagaa gcgcaaaccg aagcgatgga ccgccttctt gaaaatcatt 2244601 tgctgtattg tacagtttgc gataacaaca atggaaactg tacgctgcat aatacagcgg 2244661 aaatgatggg gatcgagcat caaaaatacc catacacgcc aaaagaagat ccttcttgcg 2244721 cggttgatat gtctcatcct ttttaccgct atgatccaaa ccaatgtatt gcctgcggcc 2244781 agtgtgttga ggtctgtcaa aaccttcagg taaatgaaac actctcaatc gactgggaac 2244841 gcgaacgccc tcgcgtcatt tgggatgagg gagttccgat caatgaatct tcctgtgtca 2244901 gctgcggtca gtgtgtaaca gtatgtccat gtaatgcact gatggaaaaa tcaatgctcg 2244961 ggcaggctgg ttttatgaca ggcattaaag aggacgtcat ggaaccgatg attgatctcg 2245021 tgaaaaatgt tgaaccgggg tatggcagca tttttgccat ttctgaagtc gaagcggcaa 2245081 tgcgtgaaac gagaacgaaa aaaacgaaaa ctgtatgtac gttctgcggt gtcggatgtt 2245141 catttgaagt atggacaaaa ggacgggata ttttaaagat ccagcctgtt tctgatgctc 2245201 cggttaacgc aatttccaca tgtgtcaaag ggaaattcgg ctgggatttt gtcaattcaa 2245261 aagagcggat cacaaagcct ttaatccgta aaaacggagc ctttgtggaa tcttcttggg 2245321 aagaagccct cgatcttgtc gcaagcagat taggatcaat taaagagcag tacggtaaag 2245381 gctctgtagg gtttatttct tcttctaaaa ttacgaatga agaaaactac gtcattcaaa 2245441 aactagcgcg tcaggtattt gaaacaaaca acgtcgataa ctgctcacgc tactgccagt 2245501 ctcctgctac agacggattg ttccgcactg tcggcatggg cggtgacgcc ggcacgatta 2245561 aagatattgc caaagcaggc ctggtcatca ttgtcggtgc caatccggcg gaaggacacc 2245621 cagtgctcgc aacacgcgtc aaacgggcac acaagctcca cggtcaaaaa ctgattgttg 2245681 ctgacctgcg taaaaatgag atggctgagc gatctgatct gttcatcagc cctaaacaag 2245741 gcacagacca agtttggctg atggctgtta cgaaatatat gatcgaccaa ggctggcacg 2245801 atcaggcgtt tattgatgag aacgtcaatt actttgaaga ttataaagaa acccttaaaa 2245861 cgtatacgct tgattatgca gaacgcatca caggcctttc aaaagaaaac atcattcaaa 2245921 ttgctgaaat gattcgtgat gctgacggca cttgtgtcct ttggggaatg ggtgtcacac 2245981 aaaatacagg cggttctgat acatcagcag ccatttcaaa cctgcttctc gctacgggca 2246041 actatcgccg tccaggtgcc ggcgcttatc ctctgcgcgg acacaataac gtgcaaggcg 2246101 catgtgatat gggaacattg cctggctggc tgccgggata tcagcatatt acagatgaca 2246161 aagcacgcgc taaatttgaa gaggcatatg gtgtcgagat tgatggaaag cctggtttag 2246221 ataatattca aatgcttcat gccattgaag aaggaaaaat gaaagctatg tatcttgtcg 2246281 gtgaggatat ggcactggtc gattcaaacg cgaaccatgt gcatgatatt ttatcaagcc 2246341 ttgatttctt cgtggtacag gacatcttcc tgtcaagaac agctcaatat gctgatgtcg 2246401 tcttgccggc cactccttca cttgaaaaag acggaacatt taccaacaca gaacgccgtg 2246461 tccagcgatt gtatcaggcg cttccgacgc ttggtgacgc aaaaccggac tggtggatta 2246521 ttcaagaggt ggcaaaccgt ttaggagcga attggaatta cagccatcca agtgacattt 2246581 tctctgaaat ggcgagtctt tctcctctgt ttgccaaagc aagctatgag gtgcttgaag 2246641 gctggaacag cttcctatgg ggcagcttca caggtgaaag cacaccgctt ctgtatgaag 2246701 acggatttaa tttccctgac aaaaaagccc gctttgccct ttctgattgg accgagccag 2246761 cggcatttcc ggaggaatat gaccttcata tcaataacgg ccggatgctg gagcatttcc 2246821 acgaaggaaa catgacaaat aaatcgaaag gcatccaagc gaaagtgccg aatgtattcg 2246881 ttgagatctc acctgagctt gcacaagagc gaggtgtttg tgacggttcg cttgtacggc 2246941 tcgtttctcc gttcggagca gtcaaattga acgcgctgat cacagaccgg gtacggaaaa 2247001 atgaactcta tttgccaatg aactcgacag acaaggagtc agcgattaac ttcttgacgg 2247061 gccctgcagc tgataaacgg acgaacacgc ctgcttataa acagacaaag gtccgcatgg 2247121 aagtgcttgg cggctgtgaa acagcgccgc ttccaaaaac aaatccgcgc aacaaaaaac 2247181 ggcatccgca aaacggagtc gaagcagaaa gaaaatggaa ccgccctggc tatgtacatc 2247241 tgactgatta aacgatagga ggaaaacgaa tggccactcc gattacgacg atcaaaaaag 2247301 aaacaaaaac agctgagcaa attaagcttg aaaaaataga agaactgaaa gagctgctgg 2247361 cggaaaatga ggacgccgtc tctaaaacga tgacgttaat gaatgaactc aatgatcttg 2247421 gaatttttga tgcggcaaca agcatgctca gagcgaagga agacattgcc aagattgcgc 2247481 ttggccaagt ttcccgcgag cctgtcacca acctcatcaa cacgatgatg gccgccggag 2247541 gcgcattgac aaaagccgat cctgagttta cagcaaagct tttagaaagc gtaatggctg 2247601 ggactgaaca ggcacaaagc tttttaaaag aagacaagaa agtcgggatt ctcgacctgt 2247661 taaaagcaat gaacgatcct gacatcaaca gagccgtcgg gttcggcctt cagtttttaa 2247721 aaggcatggg aaaagaactt cgagaacaat aacagaaaaa cagccatctc tgatgatggc 2247781 tgttttttta ttcgtcggct tcttccagac gcttcttgta aataagtgaa cggtcagcgc 2247841 aaaagaaggc accggctaaa aatacgcaat ccgctaaaaa catcgtcgat ttctggccta 2247901 atgttaagcc ttgatcaggg agaactgcgc ctatatataa aaaagtgctg actgcaagca 2247961 atgtaaaagc aaaatgcttg tagtcttctt ttaaagattt cattctattt ttgttcaaaa 2248021 gaatcacctg ccagattcat agtatacgac tattataata taatccggcg gcttacagag 2248081 aaagtaattc tatccatttg ttatatattt tcaagcgctt ggccgatatc ttccaacaag 2248141 tcttccgcat cttcaattcc tacagaaatt ctgatcaagc cgtccgtaat gccgagctca 2248201 agccggcgtt ctctcggaat agaggcatgt gtcattcttg caggaacaga aattaagctt 2248261 tcaaccgccc ccaggctttc agcaatggta aacagtttca gatttcctaa aaacgcatca 2248321 acccgttctt cactgccaat atcaaaggag atcatgccgc cgaagcccgc tccttgcgtt 2248381 tttgcaagct catgtccggg atgatttgaa gaaccagggt aatataacgt ttggacagca 2248441 gggtgattct caagaaagct tgcgattttc cgcgcatttt gatcgatcgc ttccattctg 2248501 agtcccaacg ttttgattcc tctcattaac agccaggaat cttgagggcc gagcacgccg 2248561 cctgtggagt tttgcacaaa atgcagctct tctccaagct ctttcgaagc tgtcacaact 2248621 aaacctccga cgacatcact gtgtccgcca agatattttg tcgcactgtg cagtacgata 2248681 tcagcgccta aagtaagcgg ctgttgaaaa taaggagtat taaaggtatt gtctacgata 2248741 agcagaacac ccgctttttt tgcgatatca gccatgagcg tcaggtcggt gattttgagc 2248801 aacgggtttg tcggtgtttc aatataaatt gcttttgtat tagggcgaat cgctttttca 2248861 acttcttccc tgctgctcgt atcaacaaat gttgattcaa tgccaagacg gttaagcacc 2248921 tttgtcatca cgcgatatgt tccgccgtac acatcatcag tcaacacgac atgatctccg 2248981 ctgttaaaca gcatcataac cgctgtaatg gcagccattc ctgagctgaa cgcatagcct 2249041 gcttccccgc tttccagttc tgtcacaagt gcttcgagag cggttcgagt cggattggcc 2249101 gttcttgaat actcgtagcc tgtatgctgc cctgctttcg gctgcttgta cgtgcttact 2249161 tgataaatcg gcacggaaac tgcgcctgtt ttctcatcac ctgtgattcc gccatgtatc 2249221 atcaatgttt ttttcttcat atcagatgcc tccttcgtat atttgtttgc tgatatatcg 2249281 atcgctgctg tcaggaaata ctgtgacaat gttagttcca gcggatgctt ttttcgcttc 2249341 ctccaatgcc gcataaagcg ctgcacctga agagcttccg atcagcaggc cttctttttc 2249401 tgccgcttct ttcacaagtc taaacgcatt ctcatctgtt acggtgtaga tctcgtcaaa 2249461 atggctctta tccatataat cggggataaa ctccatgccg atgccctctg ttttatgagc 2249521 gtggggctct cctccgttta aaatcgagcc caccggttca acaatcaccg ttttgactgc 2249581 tggatttttt tcttttaaga aggaagctgt ccctgcgaat gtgcctcctg atcctgcccc 2249641 tgcgacaaat gtatgaatat tcccgtcaag cgcttcccac atttcaggtc caagcgtctt 2249701 atagtaagtc gatggattta ctcggttttt aaattgcaaa acgcaataag aattttcaat 2249761 ttcagtctcc agctgaatgg ctttttgaat ggctccctgc attccgtctt gacgcggtgt 2249821 atgaatgatt gatgcgccaa gcgcttgcat aatttgctgt ttctctctgc tgaaatgttc 2249881 agggacacag aaaatcgctt tcagcccata ttttctggca cttaacgcaa ggccgatccc 2249941 tgtattgcct gccgtagctt ctataatcac tccgccgggt ttcactttgc ctgaatcgag 2250001 cgcgtcacga atcagcatat ctcccagtct gtctttgatg cttccccctg gattcatcat 2250061 ttcaagcttg gcatacaccg cgactccttc tggaacatca aagttcttca agcggagaag 2250121 cggtgtattc ccaatcagct cggtaatgtc cgtaatcact gtcatatatg tcctcctcct 2250181 taatagaggt tgtttttaga gaaaaacgga ggagaacgtt ctccccgttt taatgaattc 2250241 gtttgatcac ctttaacaca agctctgttg aatgaacagc cgcctgctct aaaaattggt 2250301 caaatgaaac atgtgattct ttgcctgcga tatctgataa cgctctgatg acgacaaacg 2250361 gcgttttaaa ttgatggcat acttgagcca ctgccgcagc ctccatttca accgcgtaca 2250421 gatcagaaaa tctcgcacgc acctcttcaa cccgcttcgg atcgttcatg aaagaatcgc 2250481 ctgttgcaat cgttcctttt gcaacctgaa tgccgtcgag ttcagatacc gcttcttcag 2250541 tgatgctgat cagcttttca tccgccgcat aagcagccgg aagacccggc acttggccgt 2250601 attcatagtc aaaagccgtt acgtctacat catggtggcg aacgtcagtg gaaatgacga 2250661 catcccctac attcaatgta tgatgaaatc cgccggctga gcctgtgtta atgacataat 2250721 caggcttgta acggtcaagc agaagcgtcg tgctgatagc agcatttact tttccaattc 2250781 ctgattttaa aagaatcact tcagttcctt catattcgcc tgttgtaaat tcacagtgtg 2250841 cgatcgtttc tgtttttgca ttttcaagtt tgtttcttaa gatggtaact tcctcttcca 2250901 ttgctccgat gactgctagt ctcatctatt cacattccct tcactttacc gtttgatcgc 2250961 ctccattatc cacacgaagt cgttttgctg agtgaatcgg actgcaaaac cttcagctgt 2251021 aaacatttct ttcaacgcat ccaatgtagg ataatgctct gtctctaaat catttgcaag 2251081 ctgataaaag ccttgagaac gggctttatc gatagcctgt tgatacgctt gcgcattttc 2251141 aaagacggta tcggcaaaca ctattttatc atgcaagtga aggtatttgc catattgctt 2251201 tatggcagcc cgcttttctt cgtcagtcaa atgatgaaaa gcatatgaac tgacaatcgt 2251261 atcagcctga aatggcggct cagggaatgt caggaagtct ccatcaacga tttccgtcct 2251321 gcctgagagc ttgtcagaag ccagtttacg cattgctgga gaaggttcga ttccaaatac 2251381 agttttgcct gcatcgagca gcttagctgt caaattcccg gtccccgggc caaattctaa 2251441 cacatgcgtt ccagattttc tgacgatggc atcaaggata tgatcgtagc ctctgaacgc 2251501 ttctttatac tgaatatcta aaccttgtac tgtttgatca taagttgctg cccaatcttc 2251561 aaagagaggg ataaattcac ggcccatatt tgtcacactc catatttaat aattcctata 2251621 agtatactat ggattaatga tggaacagtt cctataatac cacatattct gaaaagcagg 2251681 tactaaaaca ctttgtgtat tttatgccat ctcatattgc gcattgaccg caaaaaagct 2251741 tatacttcat atgacttgtg aaagctggag ggtcaagaca tgaattttca attagatctg 2251801 attaaagaca aagtggaatt ttttgaagcg gcttcattgc aggagcttga aaagaaaatc 2251861 aatacacaaa ttgaaaacaa taaagccatc atgctccggg tgaaatctgt ttcacaccaa 2251921 actcttgtgg cagaaggaag aatattgtac agcgcggtgg ttcatttctc agctgaagcc 2251981 taaaacaaaa gcagccggtt ttaacccggc tgcttttgtt tattttagct tttctacttt 2252041 tgtcggcttc cagccttttt catcgaccca tgtaatcgtg acttgatatt tattcccagt 2252101 cgccttgtcc aaaatcttgc ctttggcatc ctgagggctg ccgttatttc caagccagag 2252161 caccgtcatg ttatctgttg agacaccagt tgcgtacgaa atggctttca gcatctcagc 2252221 ccagtcttgt gagcttgaat cataagtagc ggcatgctcg ccagtctgct cagttccgac 2252281 tgctttccag tcaggatttt catacgtttt ttccacatcg ctcgatgagc cgccttctgt 2252341 tacttttgca tctttaagcc cgtcaccggc tgaatctgag cttgaatctg aatcagagtc 2252401 atctttttta gaagaagaat catctttttt ggaatcagag tcagaagact tctcagaatc 2252461 cttttcgctg tcagatgtat ctttcttgct gtcttttata tcctcatccg atttcttttc 2252521 cgtctttcct gaagccggag attcctgttt ttgcgccgtt tcagaatcct tgctgacatc 2252581 tttgctagaa ggactgttaa tgaagagatt cgctgctact acgacaatta gtatggatac 2252641 gattgcgatt aaaatgttaa gcactaaatt ggcttttctg cgtttatcac gattttcata 2252701 acgagattga ttattgctca ataattctgc actcctttat ccctcttggc tcagcatata 2252761 ttttaacatg tgctgagaag ttgttctatt tctgattgat ttcaatttcg tgtacttttt 2252821 taacaatatc ataaaacacc gaatttgtca gagccttatc tcccggtgta tccatgtgta 2252881 aaacaactag agcgtatttc ggcttatccg cgggaaaata tccggcaaac catttttcgt 2252941 agagcgtttc cttctctttt gaaagcttgc ctgtctgggc tgtgcccgac ttccctgcta 2253001 cagtatacgg aagatcttga aaccttctgc ccgttccgga aggagattct actacccgcc 2253061 gcagtatttt ttgaagctgc tgtgacgtat atttgtctat cgtttcccct ttgagcttct 2253121 gatctttaaa cgtaacgagc gttgtgccgt tcttatactc aatttgttcg gcaattttca 2253181 cctgccgttt ttctccgccg cgggcgattg tcgccatcat attggctacc tccagcggcg 2253241 ttacctttac atttttctgc ccgattgctg tttgcgcaat ggcttttttg actgatttgt 2253301 ctttttcatc cccccaaatc acgccgcttt tttcgttata cagctggcgg aaatcggttt 2253361 cgtggtacag ttttccctcc cagcctgccc gatcagtgag agccagcttc tcggacatat 2253421 cttcaataac cgagctgtct tttttcatta attgttctgc aagactcgta aatgtgtaat 2253481 tacagctttg ggcaaaactt tcatcaaaag acaaggtgcc tttgtcgtcc cccggttccc 2253541 cgtacaggtt taaattgcaa ttaaaggttt gactaggctt caccatatta ttttcgattg 2253601 cagctgcggc aatgactgtt ttaaaaactg atccgggata gattggcgtc agcatataat 2253661 tttgaagtgt gttttgccgg gacacgtctg catctggttt gcttacaatt cccagaacac 2253721 tgctattttc gatgtccagc agcacagctc ctcccttttt cagcccctgt tcatccaata 2253781 cctcctccat cgctttttga atgctttgat cgatcgttgt tttgatctgg agcggataaa 2253841 atgtattggc ttcagctgta tatttgacgt ccatgccaaa caaagggttt ccttttccgt 2253901 ccacatgata taaaagcttt gtgtcttgtt ccggaagcaa aaactcgtca aatgtccgtt 2253961 ctaaaccggt tgttccgatt tctgttgtaa tcggaaggct ctccttgtca ggatatttct 2254021 tgcgaagcag cgccggatct tggttcgtgc tccctatcgt atgtgaagca aggctgggct 2254081 tgtcttcatt ctccatatat acgccgtaaa tgccgggata tttcaaagaa ttgatttttg 2254141 tgatagattg ttttgaaagt gttttgattt tcttttgctg caaaatgacc ggtttttttg 2254201 cctgacctag tgtctggcgc aaatcatctt cagacatgcc gaggatgtcc gcaacttttt 2254261 tgatcggcca atcctgcgtc agcagaaaag ggaacaaaac aaccgcaggc tcgctttgtc 2254321 ctgtcagcgc ccgcccgttt cgatctaaaa aagagcctct tccatctgaa atgagcactt 2254381 cctccgtccg ctgtttcaca ctttcttgaa tcaaattaat tttcttttta gaaaatgatt 2254441 ctgtgaaaaa cagctggatt tctgcaagtc tcagcagaag cagaaaaaat acaatcaaaa 2254501 aagcgatgac tgccagcttc attcgtttcg atatcttcat aaaaaaacac ctcacccaca 2254561 ttgtggacga ggtgtttcgc tgctaaacag atattatgaa attttcacaa ttttcacgag 2254621 catttctccg cccggtgttt gtactgtgac ttcttcatct acttttttgc ccaagaggct 2254681 ttttgcgatc ggtgaatcgt ttgagatttt cccttcaaac gggtcagctt ccgcgcttcc 2254741 gacgatcgta tatgattctt catcaccgtc aggcagttcg acgaaagtga cggttttacc 2254801 caaaccgaca acgttagagc cgccgtcatc ttcaatgatt ttcgcattgc gaatcatatt 2254861 ttcaagagtc gtcacgcggc cctctacaaa tgcctgctct tctttcgctg aatcgtattc 2254921 agagttctcg gaaaggtctc cgaagcttct cgcaattttg attcgctcta ctacttcttt 2254981 tcgtttaacc gttttcaaat attctaattc ttgttcaagt ttttgttttc cttctgcagt 2255041 cataggaaaa actttctctt gtgccatgtc ccttcactcc ttctggttgt ccctcaacat 2255101 cttcgattat gtatgagagc ataaactaaa aaatacaaga atgagaacac agggcagtcc 2255161 tcgttcttct ctcccatata ggtactgttt atcttaaact gaatcgtgtc gttctgcaaa 2255221 tatttcgcgt ttataaacag ggaaagaagg gaattcgcac attcccttcc tgcctataca 2255281 taatatggtc agagttattt atgtctatgc tatggtatta caaaatcgcg ttttgttcaa 2255341 gaatggtttg aatttttgtg accatcagat caattgcgac gtgattctga ccgccttccg 2255401 ggataataat atcagcgtat cgtttcgtcg gctcgacgaa ttggttatgc atcggacgga 2255461 ccactgacac atattgttca atgacagaat caatagagcg tccgcgctca ttaatatctc 2255521 tcataatccg tctgatgata cgcaagtcag cgtccgtatc aacataaagc ttgatatcca 2255581 tcagatcacg aagccttttg tcttcaagaa caagaatgcc ttcaaggata ataacatcct 2255641 ttggctctac gtgaaccgtt tcttctgaac gtgtgtgaag cttatagtca taaatcggct 2255701 tttcaatcgg gcggtaattc aatagatctt gaatatgctc gattaaatag tcattatcaa 2255761 acgcaagcgg atgatcatag tttgtgttca gcctttcttc aaacggaaga tggctttggt 2255821 ctttataata aaggtcctgc tggatcatta aaattgagtg tcctttaaac tgttcataaa 2255881 tggaccgtgt gacactcgtt tttcctgaac cggaacctcc tgcgattcca atgactactg 2255941 gattcttacc catgggctgt tacttcccct ttctcatcat gttgctcgga taaatctttt 2256001 tgtctagttt gaatttgaca atttgcaggg gatggcgggc agcatctagc tcatttccgt 2256061 cttcgtccca aatggtttca atcgtatgtg taaagttttc gatttctgga ccgaaaaatt 2256121 ccacttcgtc gccttttttg aagaaattgc gctgctgaag cgtgaccatt tgtgtatctt 2256181 catcataatt cagcactaag ccgacaaaat catatgtcgt tttcttggcg tgttcgccga 2256241 acatttgctc ttcatagcct ggcgttcctt caaagaaagc tgtcgcagtg tccctgttgg 2256301 cgcacttatc aagctcttca agccattctt tttgaatcac aaagttttct ggatcagcgc 2256361 aataagcatc gattactttg cggtatacgc tgacaacagt tgctacatag tgaatggatt 2256421 tcatgcggcc ttcaatcttt aagctgtcga tccccatttc aatcattttt ggaatggatt 2256481 caatcagctt caaatctttc gggctcatcg caaatggtgc atcttcttca ccatacaaag 2256541 caacggcgtt ggcaccgtct gtttggtaga gatcataatc ccagcggcat gactggcagc 2256601 agcctccgcg gttggaatcc cgcgctgtca tgtgattgct cagcacgcag cggccggaat 2256661 atgcaataca cattgcgcca tgaatgaagg attcgatttc gatatctacc ttttctttca 2256721 tttctctgat ttcaagagcg ctagtttcac gtgccagcac gacgcggtcg agaccttctt 2256781 ccttccagaa ctggacagcc ttccagtttg aaagagactg ctgtgtgctc aagtgaacct 2256841 caacattcgg cgccactctg cggcatgttt caataataag cggatctgcc acaataatac 2256901 cggcaacgtt ggcgtctcca agcgctttta aatagtcttc aagcccgtcc atgttttcat 2256961 tatgagcgaa aatattcgtt gttacgtaga tcttcgcgcc atatttcttt gcgaattcaa 2257021 cgccttctgc aatttcttcg atcgtaaagt tatcggcatt cgagcgaagc ccgtattcct 2257081 gtcccccgat aaagaccgcg tccgctccgt aatgaacagc gattttcagc ttttcaagat 2257141 tacccgcagg tgcgagaagc tccggctttt tcgtaatcac acgctttcca ttaacgattg 2257201 tggatatttt atcatttacg gcagtcatag cttaacctcc ttttgattaa taaaccgttt 2257261 ccttgaagaa gaatccggta tcaatttttc tgtttactgg ctggatgctt tcaatgcgtt 2257321 cgatccagtc ttcttttttc gcttcgtatt cgtcacggtt ttccacgcac aaatcaattg 2257381 cttctctgta cattttggtg acttctatta ggtattcagg cattttcaaa acaccatcga 2257441 ttttgaaaga atcaattccg gcatctatca attcctcgag ctcatcaatg atgcacacat 2257501 cgttcgggct catgatgtga gtgccgtttt catcttcgaa aatcggatat ttattatcgc 2257561 gttctttatc gtgtaaaaac atgcctgatt cttttttctt tctttcaatg tccatgactt 2257621 tgccctgata ttcaaaatag tttccaatca aagaacgctt cgattggaac atgcacgtca 2257681 ttccatgcac ctggatttca atttcgactt cagcattttc tttaatctca acaatgctgt 2257741 ccatgtttaa ttctctggca agcacagaac gcgccgcacc cttgcgtccc cagtagttgc 2257801 atgtataata gttggtgcct gtcgtttctg tgctccaatg aagcttcaga tcaggcgcag 2257861 attcacgggc agccatcagc acggcaggat cgccgaatac cgctgcatcg acaccggctt 2257921 ctgctaagaa agccagatat tcgccaagct cacccacttt atcattatgg aaaattgcat 2257981 ttacagcaac gtatactttt gccccttctt tgtgagcaat ctctacggct tttgttacat 2258041 cttcacgaga aaattctccg gctaatctca agccgtatct ctgttcccca actaaaaacg 2258101 cagttgcccc agcctgtatg agcggcaaaa tgtccgctgt actcgtcggc gtcactaaga 2258161 gctctggttt tttcatgacg ttcacctctt ctttttacta atcgcaagtc cgtccccgac 2258221 aggaataatc gcagtttgat aatccggatg attcatcagc caatgattat attcatcaat 2258281 tttggctaca agcctgcgcc ttctcttcgg ttctattttg ctgtaatcct ctgccaccag 2258341 acctttaaac agcacgttgt ctgttataat caccccgtcc ggtgaaagca tcggttcata 2258401 taaatgaaaa aagttttgat actgaccttt tgcagcgtca ataaaaatga catcgtaagg 2258461 cgcggttaca tgaacggcgt cggctaattc aagcgcatct ccgtaaaaaa catgaatccg 2258521 gtcatcaagc tgaaattcct tgatattgtt taccgcttct tcatgccgtt tctcattgcg 2258581 ttcaattgta tatatttcag cagacggcag ttccagagcc attcgaatgg ctgaataacc 2258641 aatggccgtt ccgatttcta gtattttttt cggctgtttc acagacaaaa tttgaagcag 2258701 cacctccatg cccgcttttt ccataatcgg gacatgatgt tcttctgcat atgcttcaag 2258761 tctcttcacg ttatccggcc gaggctttaa taatgcttct atatagtcat ttatttgttc 2258821 ataccggtca gtcactacaa acagcctccc gttctaaaaa ggagtgcccc agtcttatgc 2258881 gcaggacact ctctgaatac atcatgatac atcggtaaac aacccgatat attttatcat 2258941 aaaaccttgc ggaaagcgaa caaaaggaga gctttttgct ctccttttat ttctcatttt 2259001 ttgaggaaat gtatttttct tttgctttat tatgctcttt tagcgttttt gtaaatacga 2259061 cctcaccatt tgatttggcc aagaaataca gatagtccgt tttatccgga tgcagcgctg 2259121 cttcccatga tgacatgccg gcattggcaa tcggccctgg cgtcagccct gtgtttttat 2259181 acgtattgta tggtgaatcg atttccagat ccttataaag aacccgatct ttatgcttgc 2259241 ctgccgcgta caggacggtc ggatctgttt ggagcggcat tttctttttc aggcggttat 2259301 aaaagacgct cgcaatttta tggcggtcgg ctttttcagt cgcttcttct tctatcaaag 2259361 aagccattgt cagcagctta tgcacagaaa ctttgttttt cttcatttct gatttatatg 2259421 tttccacata agaatttgtc tgcttaatca ttgccttgat aatgtcttca agtgatgtgt 2259481 ccggatcgtt aaaagggtat gtagccggga ataggtaccc ttcaagcggg tgcttaatgt 2259541 ttttattgaa aacatcattt gtcacagtgt ccgggaattc tttcttcagc tgattgataa 2259601 atgtttcatc gtccagcttc gctatgactt gttttttaga gtattttgtt tcatcagcaa 2259661 tagcagccgc gatttgggtc agctgtgctc cctcagtcac tgtgatttga aaagcgtaac 2259721 ctgtagcccc gcttgtcagc ttctgaataa tggcatctaa atccatacct ttattcagat 2259781 ggtagaatcc ggcctgaaac ccggaagcac ctttatattt cacatagtac tgaaacgcct 2259841 tctcgctttt tatgacatca tttttcttta atatcgatgc gatggctgaa acagacgaac 2259901 cgctcggaat gttaatatta actgtcgttt tactgtcttt ttcaacaggt tcaagcaatg 2259961 atttcccata taaaaatgcc ccgccaatga tgagaaacag cacaacaatg gaagacagta 2260021 tgattctttt tttattaaaa aacgattttt tttgctgatt gatatacatt aggtctcctc 2260081 ccatcagctc ttatactaca tgattcattg tatttcggca atttattaca aaaagaggcc 2260141 tgcataaagc agaaaaaagc cggagcagta tagctccggc tttggtttgg cgcgatgttt 2260201 tactcttcgt cttcgtccgc taagaatgtg tttagtgttt cttcgatcat atcccattct 2260261 tcgtcagttt caatcgggaa tagctcaccg ttttcaccgt cttcgtttgg cgtgaagctg 2260321 gaagcaagaa tttctacttc ttcgtcatct tttgattcga ttggatagta caagacataa 2260381 gatttgccaa actcttcatt ttcaaatgta aacagcactt cacaaagctg ttcatttcct 2260441 tgatcgtcaa caattgtaat atttttttcg ccgtgttcca ttttcttcac ctctggcttt 2260501 aatttaagct gtcaagatat ccttgtaaaa tcataacagc cgccatttta tcaatgactt 2260561 tttttcgttt ttgcctgctg acgtcagctg caatcagcat tttttcagcc gccattgtgg 2260621 taagacgctc gtcccacagc acaacaggaa cattgtacgt tgtttcaagc actttcgcaa 2260681 atgtttggct ggcttcgcct ctcgggccga ctgttccgtt catgttctta ggaaagccga 2260741 gcacgatttt atctatagta tagtccttta tcagttcaga taaacgggat aaaccataat 2260801 cgccttctgc ttcatttatc tttatggtct caatgccttg agcagtccag cccatttcat 2260861 cgctcagagc tacaccgagt gttttggttc ctaaatcgag tcctaatatt ctcattcttt 2260921 atttacgcct ctttatgctg ttctaaataa gactttacca attcctcgat taattcgtct 2260981 ctttcaagtt tgcgaattaa attgcgagcg tcacgatgcc taggaatata agcgggatca 2261041 cctgacagca agtatccgac aatctggttg attggattgt agcccttttc ctgaagcgcg 2261101 tcatacactg taatcagcac ctcatttacg ttagtctcag cagaatcatc ggagaaatta 2261161 aatttcatcg ttttatcaaa cgagctcacc gttttgcacc tctttcccaa attcgcaggc 2261221 aaagttcagc ctggggtcct aatcttacca tcattctaca ctacatgggc gaattataaa 2261281 acggatttca cccaatcttc tacagaagcc aaagcttctt ctaatttttc cggctgttta 2261341 ccgcctgcct gcgccatgtc cggacggcct ccgccgcctc cgccgcaaac ttccgcagct 2261401 tgtttaacca gcttgccggc gtgaagtcct ttctcaatga ggtcctttgt gactccggca 2261461 gagatattaa ctttatcgtt ttgtaccgca ccaagcacga tcaccgcaga gccaagcttt 2261521 gctttgagtt catcgaccat agtgcggaga tgattcatgt cttttgcatt tacttttgcc 2261581 gcaagcacgt ttacgccgtc aacttctttt actttcgaca ggattgctcc tgcttccacg 2261641 ttgcctagtt ttgcaagaag agattcattt tctctttgtg catccttcag ttcagcctgc 2261701 agagccgcga cccgtttcgg cacttctttg atatttgttt tcagctcgtc agcggtctgc 2261761 ttcaatacag aaatctggct gttcatttcg acgtaagcgc cttgtcccgt tacagcttca 2261821 atccgtcttg tgcctgctcc gattccggat tcagaaacga ttttaaacaa gccgatttct 2261881 gctgtatttc tgacgtggca gccgccgcac agctctaagc tgtaatctcc aacttgaacg 2261941 acacggacaa tatcgccata tttttcgccg aacagtgcca tcgcacccat ttcttttgct 2262001 tcagcgatcg gtttcaaatc aatgctgacc gggatgctcg cccagatctt ttcgtttacg 2262061 attctttcaa tttgttcgag ctcttctttt gtcacttggc caaagtgcga gaagtcaaaa 2262121 cgaaggcggt tttccgttac aagagagccc gcctgattga catgagttcc aagaacatct 2262181 tttagagcct gatgcaataa atgcgttgcc gtgtggtttt taatgacgcc gcttctcata 2262241 tggtcttcaa cttcagccgt aacatgcagg cctttttgaa cagtaccgct ctccacaaca 2262301 ccttcatgca catgctggcc gttcggcgct ttttgaacat ctttaattct tacaactgcc 2262361 tgctcgcttc ggagatagcc tttgtcgccg atttggccgc cgctttctgc atagaacggt 2262421 gtttcatcaa gaatgatttg aacgctttct ccttcatgag cctcttcgat taattggccg 2262481 tcctgaagaa gcacaatgat attggcatca gctttggttt gagagtagcc gacaaatgtg 2262541 ctttcaactg tcacgtcgcg cagtgcgccg ccctgcacct gcatgctgcc gacatcctgg 2262601 cgggcgtttc ttgcccgttc acgctgctgg ttcatttcct cctcaaagcc ctcatggtca 2262661 accgtcatgt tctcgtcttc tgcgtattct tcagtcaatt caaccgggaa tccatacgta 2262721 tcatacagtt taaacacatc agcacctgag ataacgctgc tgcccttgtc tttttctttt 2262781 ttgatcattt ctgacaggat cgcaagccct tcattaaggg tctcatggaa gcgttcttcc 2262841 tcggttttaa tgacttttgc gatgaaatcc gctttctctt tcacttcagg atagaaatca 2262901 gccatgattt ctgcgacaac cggcactaaa tcaaacatga acggacgatg gatgttgatc 2262961 gttttggcat aacgcacggc acggcgtaat aagcgtctta atacatagcc gcggccttca 2263021 tttgacggca gcgcaccgtc actgacagca aaggcaaccg ttctgatatg gtcagcaatc 2263081 actttaaacg cagtgtcttt cacattgtct ttgccatatg tttcaccaga aatcgattct 2263141 gttgctttaa tgatcggaac aaacaaatcg gtgtcaaagt ttgtcggaac attctggatg 2263201 acagacacca ttctttcaag acccatgcct gtatcaatat ttttctttgg aagcggtgtg 2263261 tacgtgccgt cagggttatg gttgaactct gagaacacaa ggttccatac ttccaggtaa 2263321 cggtcgtttt ccccgcctgg gtaaagctcc ggatcttctg gatcattacc gtatgcttca 2263381 ccgcggtcgt aaaagatttc cgtattcggt ccgctcggcc cttcaccgat atcccagaag 2263441 ttcccttcca gacggataat tctttcttca ggaataccga tttttttcgc ccaaaactca 2263501 tatgcctctt catcttcagg atgaaccgta acagagagaa gctctttgtc gaagccaatc 2263561 cacttgtcgc tcgttaaaaa ctcccaagcc catgtaatgg cttcttcttt gaaataatcg 2263621 ccgatggaaa agtttccgag catttcaaag aaagtgtgat ggcgcgcagt tttacctaca 2263681 ttttctatat cgtttgttct gatcgctttt tgagcgttta cgattcttgg attttccggc 2263741 acgacacggc cgtcaaaata ttttttcagc gtcgcaacac cgctgttgat ccaaagcagt 2263801 gaaggatcct catgaggcac taatgacgcg cttggctcta ccgcatgtcc tttttcttta 2263861 aagaaatcca aaaacatttg acgcacttcc gcagaagtta agtgtttcat tgtatttcct 2263921 cctctataaa aatcgaaatt ctcttcagtg acagcaaaaa agccctcccc ctatgcaaac 2263981 caacgtttac acagggacga gagctgtctc gcggtaccac cctgattacg ggcattcatg 2264041 cgcccgtcac ctttaaccct gtaacgcagg ataagcggca gtgattaact gcactcagga 2264101 ttagcttcct ccgatcttct gataaagctc ctttcagctt atggagcttc tctctttaac 2264161 agggcttcgg cgtactcaga tccgtcactc gagattcgta tgtattctac gagaaattat 2264221 agacaagcgg cacgccgatg tcaatgctcc gtcctcatcc gcaaaaaatg gatcatcatt 2264281 acttttaaaa cagccgtcgc aggaacagcc agaatcatcc cgacgatacc cgcaagctcc 2264341 cctccggcaa ggagtgcaag catgataacg accggatgca ttttaaggct tctgccgaca 2264401 atgaacggac tgaggatatt tccttccata aactgcagaa taaacaccgt aatcaccaca 2264461 acaagaaccg ccttgactga gatcgtcatc gcaattaaca acgcaggaac agctccgatg 2264521 aaagggccaa aatacgggat gacattcgtt accccagaga taaggccaag tatcagcgga 2264581 tacggaagcc caaataccca gaacgaaatg cctgcaatca cgccaagaat caagcagacc 2264641 aaaagctggc cgcggatata atcgccaagc gaatcatcca catcccgcaa aaaggcgctg 2264701 ccccgctttc tccacgactt cggagtcaag taccatactg tctttttcat taactcaatg 2264761 tccttcacca tataaaacac gagaaaaggg attgttgcag caattaagaa gtaatcaagc 2264821 acattgcgga tcccgctgat cgcaccctcg atcgttcccg caaaaaacgc ctccgtctgg 2264881 cggatcattt tatctatacg gtgatgcata ccatcaggcc agtcatccgt atggttatgc 2264941 acatgaagaa gaagcccgtt atacgtttcg gcaaacatgg gtatattttc tgacaaatcc 2265001 gtcagctgca cgattaaaac aggcacccct ttatacaacg cccagccaat cccgccaaaa 2265061 aaaagaacat aaatgaccaa gatgctcaaa gtcctaggca atcctttgcc atgcagccat 2265121 tctgtgaccg gaagcaataa ataagatata aaaatagaaa tgatcaaggg aataaagatc 2265181 gtttttatga cgagccaaaa gggtgaccat aacatatcaa gcataaaaaa gacatagact 2265241 gttaacagaa ccagcaaaca aatagccacc cacaacaaaa gctgcaccgg tttttggagc 2265301 atctgctttc acctcaccta tatcttttga ggtttacaag gaattattct ttatgtttct 2265361 ttagtcagtc agaagtcatg gacatttttt cacttttaat tttcagaaaa gtttgatcat 2265421 ttactttttg gtcaaatttt ctgataggag gattgcgatg atcacatttc aaaatgtaaa 2265481 caagcattac ggagattttc acgtgttaaa acaaattaat cttcaaatcg aaaaaggtga 2265541 agtcgttgtt atcatcggcc catccggttc cggtaaaagc acattgctca gatgcatcaa 2265601 cagacttgag tcgatcaatg agggagtgct tacagtaaac ggcaccgcca ttaacgacag 2265661 aaaaactgat atcaatcaag tgcggcaaaa tatcgggatg gtgtttcagc actttcattt 2265721 atatccgcat aaaacagtgc tgcagaacat catgctggct ccggtaaaag tgcttagaca 2265781 atcacctgaa caagcaaagg aaacggcgcg gtactatctt gaaaaagtcg gcatcccaga 2265841 caaggctgac gcctatcctt cccagctttc cggcgggcag cagcagcgtg ttgccatcgc 2265901 aagaggactg gcgatgaagc cggaggtcat gctgtttgac gagccgacat cagcacttga 2265961 tcctgaaatg atcggtgagg tgctagatgt catgaaaaca ctcgccaaag aaggcatgac 2266021 aatggttgtc gtgacacacg aaatggggtt tgccaaagaa gttgccgacc ggattgtctt 2266081 cattgacgaa ggaaaaattt tagaagaagc agtgccggct gaattttacg cgaacccgaa 2266141 ggaagaacgg gcccgcttat tcttaagccg tattttaaat cattaaaaca gaaatggggg 2266201 agcttgtatg aaaaagattt tttctttagc attgatttct ttattcgctg tcatcttgct 2266261 tgccgcttgc ggcagcaagg gatcaaacgg agaagcctca aaggagagca aaaaagatac 2266321 gctagccgcc attaaagaca atgacaaaat tgtcttcggc gtaaaaacgg acactcgact 2266381 gttcggtctt aaaaatccaa gctcaggtga gattgagggt tttgatattg atattgctaa 2266441 acaaatcgct aaagacattt taggtgatga gaaaaaagct caatttaaag aggtcacctc 2266501 aaaaacaagg attcctatgc tgcaaaacgg ggatatcgac gccattgtcg ccacaatgac 2266561 gatcactgaa gaacgaaaaa aggaagttga cttttctgat gtctatttcg aggccgggca 2266621 atcgcttctc gtgaaaaaag gcagcaaaat caagagtgtc gagaatcttg gcaaaggctc 2266681 aaaagttctt gcagtaaaag gctccacctc ctctcaaaac attcgtgaaa aggcgcctga 2266741 agcatctgtt ttagaatttg aaaactacgc agaagccttt acagccctta aatcggggca 2266801 aggcgatgcc ctcaccacag ataatgcaat tttatatgga atggctgatg aaaataaaaa 2266861 ttatcaatta acaggaaagc cttttacaga tgagccttac gggatcgccg tgaaaaaagg 2266921 gcaatctgct ctcgcgaaag aaatcaacgc ttcacttaaa aagatgaagt cggatggcag 2266981 atacgatgaa atttataaaa aatggatcaa agaagaccca gctgaataac aaccatcccg 2267041 ggatgagcag gcgatgctca tcccaatttg ataaggagtg aataggcaga tgaatgtgtc 2267101 aattcttttc gataacttca gcatgtatat ggacggtttt taccatacct tgctcgcaag 2267161 tgttatcgcg ctggccggca gttttgtcct cggcgttgct gtagcggtta tgagaataac 2267221 agtctttaag ccgctgcaat ggctcgggac cgcatatgta gaattcatcc gcaacatccc 2267281 tcttctttta attacctttg ttttctattt cggacttcca aacgcaggcc tgaggcttga 2267341 cggttttcaa gcgggaacgg ttgctctcac catttatacc tctgcgttta tcgctgaagc 2267401 catcagagca ggcatccagt ctgtttcaaa agggcagatg gaagcggcac gctcgtcagg 2267461 ctttacctac agccaagcca tgctccatat cattttgccg caggcaatca aaatcgtcat 2267521 tccgccttta ggcaatcaat ttttaaactt agtcaaaaac tcttcgattc ttggggttgt 2267581 ggccggattg gatcttatgt accaagccga tttagtttcg tcgagcacac tcgttgtatt 2267641 tgatgtttat atttttgtgg cgctttttta cttagtgctg acgattccgc ttagcatcgg 2267701 tgttaactat ctggaaaaac ggctggaaaa aagctattga taaggagtga gttacattgg 2267761 atttcatcgg tgcttattca caggagcatt tagcgttttt atgggatggc tttctcgtca 2267821 ccttgtacgt tgctttcatc tccatcattc tgagcttttt cttcggttta atcgcaggca 2267881 ccctgcgtta tgcgaaagtt cccgttcttt ctcaattgat tgcagttctc gttgaaacga 2267941 tcagaaacct ccccttgctg ttaattattt tctttacgtt ttttgccctt ccggaaattg 2268001 ggattaagct tgaaattaca gctgctgcaa ttacagcact aacgattttt gaatccgcta 2268061 tgctatctga aattatccga agcggactga aatcaattga caaaggacaa attgaagcgg 2268121 cgcgctcctc cgggctgagc tatacacaga ccctgttctt tatcgttatg ccgcaagcgc 2268181 ttcgccgcat ggttccgccc atcgtaagcc agtttatttc tttattaaaa gatacatcgc 2268241 tcgctgttgt gatcgccctg cctgaactga ttcacaacgc gcaaattatt aacggccaaa 2268301 gcgctgacgg cagttatttt ttcccgatct ttttacttgc ggcccttatg tatttcgcag 2268361 tcaactacag cctttcactc gcagcaagac gcctcgaggt ccggcaaaca tagaaaagga 2268421 tactctttgg agagtatcct ttttgcatta aaacattttc gtaattcttc ttctcatccg 2268481 cttcatgctt cgattattca gcatgtcaga ttgagtcgcc attcggtaca cgagagctcc 2268541 ggctcccatt gccaaaagag aagtcatcgt ccgattcatc ctgcgcatct cctttcatga 2268601 ttaaaaattg atgctgcgtt catcctcaga aaacaaatca tccaagctgc ttaacgttcc 2268661 gtcttcttcc acctgatgag ttgcaatctt ccctttcgcc actgtcagtt caataaaaca 2268721 gccccagcaa taatattggt tcacgccgat tttgccgata tccttacttt tgcaattcgg 2268781 gcatataagc atacctcaca cctctatccg ttcagaacga tctcgtcttt ccgcacctcg 2268841 acaagcgaat ccgctctttg gatctggcgc ttgcttcccg ccaggtcaga aaagaaaccg 2268901 tccgagagtt catatgctac gattatgccc ctgtccaaac aaaagtatac atcttccagc 2268961 atccccaata tatccccctc ttgcgatttc acaagcttca tcttcatctg ctcgtatgtg 2269021 aagcatgatt tcggaagagg caaaagctgt tctgaactga ccgaagccaa tatgcggtca 2269081 tcaaaaatgg aagagatatc acacgcccgt aatagcgcat gatgatgatg caaaaagcgt 2269141 ttttgtgcaa gaataaaccc aagacaatct cctttcagag aaaaacaaat atcggaaatt 2269201 gtcccgagat aactagaagt tcgttctgag tatactggga atccttctac ttcatggcat 2269261 gttctcaaag tgtgatcaac caccttttgt tgaacaggct taggttttgc tttgcgcctt 2269321 agactcatac gatgaaatca attccactgc aaatgaaaaa aaactcccgc ttgcacggga 2269381 gcattttatt gctgttcttc tttcataaaa tcgaatggtg taatgccttc catgccaatg 2269441 ttggcgtcgt gtacgctgaa cgggagctct ttttgcaaag cttcaagctc ggcatccatt 2269501 tcctcaacct gtacggacag cctgtttttc aaggaggtct gtctgacagt tgcatcatta 2269561 tttttcacgc cccactccag cgcctcctct tccccgcata aaatgagaaa tttcttcgct 2269621 cttgtaatcg cggtataaag aaggtttctt ctgagcattc tataatagcc tttcacaaca 2269681 ggcaaaacca caatcggaaa ttcacttccc tgcgatttat gaatagaaca gcaatacgca 2269741 tgggtaaatt gattaaaatc ttttttcgta aatgtcattt cattgccgtc aaaagaaacg 2269801 acggccatgt cttctttttc tgtattttcc tttgcataaa atatcgacgt gatttcgcca 2269861 atatctccgt tgaacacatt gttttccggc tgattgacaa gctgcaaaat tttatctccg 2269921 gttctgtaga caacatcccc gaacttcaat tctctccgtt tttctttagg aggatttaaa 2269981 atgtcctgca gcatcacatt caattcatta atgccggctt ttcctctgta catcggagcg 2270041 aggacctgaa tgtcctttgc tgtatagcct tttttcaatg cattggcgac aaccttctca 2270101 actacttctt tgatttgcga cccgccgcag cgaataaagg aacggtcctt tgtcggggca 2270161 gtcaaattgt tcggcagcaa tccatttttc atctggtggg caagctcgac gattgatgac 2270221 ccttctgcct ggcgatagat gtctgtcagt ctcacagtcg gaatcacctg ggatgccagc 2270281 aggtctctga gcacttgtcc cggaccgacg gaaggcagct ggtcttcgtc tccgacaatg 2270341 atgatttgta tatgatcagg gatcgccttg aacaaatgat tcgccagcca tatatcaagc 2270401 atactggctt catcgataat taacagcttc ccttcgatcg gctgatcctc tgtatgagta 2270461 aagccttcag cgccgttcca gccaagcagc ctgtgtatcg taactgcagg gagtcccgtt 2270521 gattcactca tccgttttgc tgctctccct gtcggagcgg ccaaaacaat cggaaaagct 2270581 tcatcctttt tataagctga cgggtctagt gacacaccgt gaagctctcc gtagagctcg 2270641 acaatccctc tgattaccgt cgtttttcct gttcccgggc cgcctgttaa aagaagcatc 2270701 ggcgaggaaa gggctttttg aatcgcttcc ttctggctgg gggcatactg aacgtccatc 2270761 cgttcttcca gttctcccaa cgcgagcaaa aactctgatt cgggaaactg gttctcatat 2270821 tcggtttggc tagcgatatg tttcacacgc tttgcaacgt tttgttctgc gtaaaacagc 2270881 gaaggaaaat aacagcggcc atcttctatg acaatgtctt tattttctcc aagggcaata 2270941 attgcgttag cggcatccat ttctgtaatg cgctgccctt cccttgctga ctggtttaac 2271001 agtgattgag tgtcgatgat cagctgttcc gtttctatgt acgtgtgccc ctctgacaga 2271061 caagtcgttt caagcgtgta caaaatagca gcttttaccc gctcaggatg attacccgaa 2271121 agacccattc tgctgcccag ctcatccgct tttccaaacc cgatgccttc tacatccttc 2271181 acaagctgat aaggattttc ctgaatcttt tcaagcgtct cggattcata ggcttgatag 2271241 attttcatag acagctgcgg gccaaagcca aactgattca aggaaatcat gatttgctcc 2271301 agtccctgat gccgctgcaa tgcgccagcc agcgtgtctg ctttcttttt tgagagtctg 2271361 ggaacatcat aaagcactga agcatcagcc aatattttat taatggcgct gtcgcccagc 2271421 tttttcacaa tttcttcagc tgtttttttg ccgatcccct cgaataaatc actcgataaa 2271481 tattgaatga tgccttcctt agtcgttgga atctcctttt tgaaatgctc cgcctgaaat 2271541 tggagcccga attttggatg ggttacgatc tttccgtaaa acgtgtaggt ctcttcttct 2271601 tgaagcgcag ggaagtagcc cgtcacggat acggctttat cttcaatggc ttcggaggtc 2271661 tctgtgactt tcactttcag aaccgtatat aaattggtgt cattatgata gatgactgtg 2271721 ttgactgtcc cttttaaata gggctcttcc tccagtttaa gctgatccgg atgctgctgc 2271781 acgagctgtc cctcctcctg tgcctgttat gatggatcaa tcagtttttt agcatgaagc 2271841 gcaagcatat gatctggctg gatatcgatt gccttgtcca gcatttccag cgctttttct 2271901 cggttttctt tataagcata agtgacaccg gcattataaa atgcatctgc atgccccggg 2271961 tcttgctctg tcacagctgc gaattggctg agcgcttcgt ccagcatgcc ctcgttggct 2272021 aagcacatcc cgaattgaaa acgcgcttcc gtatcgtttt cattcagttc gactgctctt 2272081 tgtaaatatg gcagtgcaag cttaggctgt tcgagcttga caagtaccgt tccgagcatg 2272141 taaaacaggt cgccgttttc catccccgca cgtagcgctt tttcaaacat gtctttcgct 2272201 tctttgtaca tttcttttac aacatagaca tttcctgctc cataataagc agtggctgcg 2272261 ctactgtcta attcaagcgc tttatcataa aacgcaagcg cacgttccag ctcgtttacg 2272321 gatgaaagaa ggttggcaaa attgatatac ggaatcgcgt cttctttatt ttcttcaatc 2272381 gcttttgtaa atgcctctgc cgctttctcg taatcgcctt cctgcatcgc ctctataccg 2272441 agttgattat aatccaccga tcatcttcct ttcattaaaa aaccccaact cagtgttgag 2272501 gtttttcatc ttttatacgt accacaattt tgttccgtct ttgtacacat catcaattgt 2272561 cccgccgcca aggcattctt cgccgtcata gaagacaacg gcttgtcccg gcgttacagc 2272621 gcggacttgt tcatcaaaga tgacttccgc ttcaccttcg ccagtcatgc gcactgttac 2272681 tttatgatcc tcttggcggt aacggaattt agccgtgcag gaaatctctt cgcccttcat 2272741 gatatccgaa cgtacccagc tgatatttgt tgctgtgatt ttgtcggaat ataaaagcgg 2272801 gttatggaac ccttgatcta cgtagaggat gttcttttca agatctttgc ctaccgcaaa 2272861 ccacggctcg ccgcttccgc cgatgccaag gccgtgacgc tgtccgatcg tatagtacat 2272921 caacccgtcg tggcggcctt ttacttcgcc gtccatcgtc atcatatcgc ccggctgtgc 2272981 agggagatat tggctgagaa acgttttgaa gttgcgttcg ccgataaagc agatgcctgt 2273041 actgtctttt ttcgtcgctg ttgcaagttc tgcttctttg gcaatttcac gcacacggct 2273101 tttttgaagt tcgccgatcg ggaacatgac tttgctcagc gtatcttctg tcagctgatt 2273161 caggaagtac gtttgatcct tgttttcatc aatgccgcgc agcattctga cttttccgcc 2273221 gcttctgtct actcttgcat agtggccagt cgctaaatag tcggcgccaa gtgacaatgc 2273281 atgctccaaa aaggccttga atttaatttc tttgttgcac aatacatccg ggtttggtgt 2273341 tctgcctgct ttatattcat caaggaagta ttgaaatacc ttctcataat attgcttttc 2273401 aaagtttacg gcataatacg gaattccgat ttggttgcag acgcggatca catcttcata 2273461 atcctctgtc gccgtgcaaa aaccgttttc gtccgtatca tcccagtttt tcataaagat 2273521 tccgattaca tcatagccct gttcttttaa cagcagggcc gccacagatg agtctactcc 2273581 gccggacatg ccgacgacga ctcttgtatc ctccggccgt ttttccattt cattcactcc 2273641 aattactacg ccgccttatt atgtcagccg tttgacaacg tcggccacat gtttggcagc 2273701 agttttcact tgctcagccg tattgccgag gccgaagctg attcgaatag aggacgtcag 2273761 ccggtcactc tcttcgccga acatagcagt cagaacatgt gacggcagga ctgaaccggc 2273821 cgtgcacgct gaaccgctgg agacagcgac accagccata tcaagattaa ccagcagcgc 2273881 ttccactgac acaccgggga aataaagatt cagaacatgc ggcagactat gctctttgtc 2273941 cccgttgacc tcgaatgcca cacctgcatc tctaagcgtg tcggcaaaga ttgctttaaa 2274001 cgattgatac ttctcgtttt tttcgtcacg ttcttcactt gacagcttga tcgcttcttt 2274061 cagcccgaca atgcctggaa cattttccgt tccggcacgg cgttttcttt cttgctctcc 2274121 tccgaataaa aggggtgaaa gcttcacatc tttactagca tataaaaagc ctgtcccttt 2274181 tggcccgttg agcttgtgcc cggaaacaga cagaaggtca atatggctgt ttttcacatc 2274241 aattggcagc aacccgaatg cctgaacagc atcggtatga aaataagctt tgtgttcctt 2274301 taacagctca ccgatttctt cgatcggctg cactgttccg acttcattat ttccatacat 2274361 cactgtcaca aggattgtat catcacgcag tgcttctttc acctgttttg cactgactct 2274421 tccattttgg tcaacgtcca gatacgttat gtcaaatccg tctccctcaa gtttttcaca 2274481 tgtgtgaagc acggcgtgat gctcaatttt tgttgtgatg atatgtctgc caagatcttt 2274541 tcttgcaagt gcggttccca tgatcgccaa gttatcagct tccgttcccc cgcttgtaaa 2274601 aatgatctcc tgctctgccg ctccgatttc tgctgcgatc tgcgctcttg cttcatccac 2274661 ccattttcga gattctctgc caaatgaatg aatactggag ggattaccga aactgccgga 2274721 gaagtgcggt atcatttgtt ccagcacgcg ctcatccatc ggagacgttg cggcatgatc 2274781 taaataaatc cgttccatta tgtttacacc tctgatctaa atatagaaca tataagcttc 2274841 ttgctctccg tctgtatagc tggcaagatc ctctaatgtt gtactgtcta aaacctcttt 2274901 tacagcatcc cggatgcgaa tccagagctc acgcttggca ggctcctcat cttccagcac 2274961 ttcaacaggg ctgatcggcc cctcaagcac acggataata tctcccgcag taatggcatc 2275021 cggctcactg cctaatacat atccgccata tgcgcctctg atgcttttca ctaaaccggc 2275081 atttctgagc ggcgatacca gctgctccaa ataatgctcg gacaaattat tcgtctgtgc 2275141 gatgcttttt aatgaagtcg ggccttcacc gtgctttttt gcaagctcga tcataatggt 2275201 gagcccgtat cttcccttag ttgatatttt caacatgaac acctctgtta tttcatgatt 2275261 ttccacattt ataatggtaa tttctatatg tttcgtccgt ttattatctt atagaccaac 2275321 tgttattata acataccttc agcgaatttt cattgaggca gaaggaaagg ggcctttacc 2275381 cttttctaat gtacggtttt ccgttaccct gtaattaagt aaggagagat gatagatgaa 2275441 gccattggca tatcggatgc gtccgacaaa aatagaggat attatcggcc agcagcatct 2275501 ggtggctgaa gataaaatta ttggcagaat ggtccaggca aaacatttgt catccatgat 2275561 tttgtacggg ccgcccggaa ttggaaaaac atcaatcgca acagcaatcg ccggttcaac 2275621 aagtattgct tttcgaaagc tgaatgctgt cattaacaat aaaaaagata tggaaatcgt 2275681 agctcaggaa gccaagatgt ccggccaagt gattttgatt ctggatgaag tccacaggct 2275741 ggataaagga aaacaggatt ttctattacc ctatttagaa aacggaatga tcattttgat 2275801 cggagcaacg acggctaacc cgtatcatgc cattaatccg gcgatcagaa gccggaccca 2275861 gatttttgag cttgaaccgt taacacctga actgattaaa caggcactgg aacgtgcgct 2275921 ccatgatgag catcggggcc ttggcaccta ttctgtatcc attgatgatc aggcgatgga 2275981 gcattttgcc cacggatgcg gaggagatgt ccgctccgct ttaaatgcgc ttgagcttgc 2276041 cgtgttgtca acgaaggagt cagcagacgg tgaaattcac attacattag aaaccgcgga 2276101 agaatgcttg cagaaaaaaa gcttttctca cgataaagat ggtgacgcgc attatgatgt 2276161 actgtccgct tttcaaaaat caatccgcgg ctctgatgcc aacgctgctc ttcactattt 2276221 ggctagatta attgaagccg gtgatctgga gagcatcgca agacgattgc ttgttatcgc 2276281 ctatgaggat atcggtttag caagcccgca agccggccct agagtgctga acgctattca 2276341 gaccgctgag cgagtcgggt ttcctgaagc gcgaatcccg ctggccaacg cagttattga 2276401 gctttgcctc tcaccgaaat caaactctgc cattctggca atcgatgagg ccctggcaga 2276461 tatcagagcc ggaaaaattg gggatgtccc gaagcattta aaagacgcgc attataaagg 2276521 agctcaggaa ttaggaagag gaatcgacta taaatacccg cacaattacg acaacggttg 2276581 ggtcgaacaa caatacctcc ctgatcctct gaaaaataag caatactata agccgaaaca 2276641 gactggaaag ttcgaatctg ccttaaagca ggtgtacgat aaattaatga aaagaaaata 2276701 aaacaaaaaa acagccttga tcatcaaggc tgtttttatg cattatttat ccttcacacg 2276761 tttgatttca atgtctttca aaagatccat gacaacatgt ccgcccataa tcaaacctgc 2276821 aactgacggc acaaaagcat tagaggaagg cggcattttt gctttacgta ttttcgcttc 2276881 gtcattcccc acttcttttc tgacatcttc ccgaataaca atcgggcttt catcagagaa 2276941 aatcacttga acgccttttt tgataccctc cttgcgtaat ttcgtacgaa cgaccttcgc 2277001 aattggatca gtgtgcgttt ttgagatatc agcgatttgg aagcgtgtcg gatccgtttt 2277061 atttgcagca cccatgctgg agatgagcgg aatatcccgt tttagacatt ctttcattaa 2277121 atgaatttta taacaaatgg tgtctgacgc atcaatgaca tagtcaagac catagtcaaa 2277181 aaactgctca tacgtttcct ccgtatagaa catttttaac gcgatcactt cacactccgg 2277241 gttaatgtct gcgatccgcg ccttcattaa atcaactttc ggctgtccga cagttgaaag 2277301 cagcgcgtga agctgacgat ttacatttgt aatgtcgaca tcatctttgt cgacaagcag 2277361 aatgcggccg acgcctgacc gcgcgagagc ttccgccgcg aacgacccga ctcccccgac 2277421 tccaagcaca gcaactgtgc tgtttttcag cgtttcaagg ccttcttttc cgatagctaa 2277481 ttcattgcgt gaaaactggt gtaacaagaa cctcactcca cattcgtatt ctggtttcat 2277541 ctataaaatg gctgatccat gagcagccgt tttttctgcg cacaaaaaat aaagtcccaa 2277601 tagtgccgtt gcagctttcc tttgttttga acccgctctc agcaggtggg tgccctcttt 2277661 taaatcttgt aagtcctctt taccgaatga aaagaggcat gtacgccatt taaaaatgcg 2277721 ggctcccaaa tcaaaaaaat gttcggtcaa aactaggtgt acaactaaca catcaggact 2277781 ttatttaact tgtcaaaatc atatcacaga cgattttgat tttcaagaat cgaactgcaa 2277841 attcagttct taactttttt cttgatagaa agatgaagct cgtcaagctg ggcgtcgctt 2277901 acttcgcctg gcgcttctgt catcaggcag cttgcacttg ccgttttcgg gaatgcaatc 2277961 gtatctctca ggttcgtacg tccagcgaga agcataacga gacggtctaa gccgagtgcg 2278021 attccgccgt gcggaggagc gccgtattca aatgcttcca gcaggaatcc gaactgttca 2278081 gccgcttctt ctggtgagaa gccgagaagc gcaaacattt tttcctgaat atccttttcg 2278141 aaaatacgga ttgaaccgcc gccaagctca tagccgttta agacgaggtc ataagcttgc 2278201 gctttcatgt cttcaggcgc tgtttcaatc agctcaaggt cttctcggac aggcattgtg 2278261 aacggatggt gcgctgcgta aaaacggcct tcttccggat catgctctaa tagcggccag 2278321 tcgatgaccc ataagaaatt gaacaatttt tcgtcaatca gtccgcgttc tttcccaagc 2278381 tttaagcgca gggcgccgag tgatgcggcc acaacttcga attgatccgc tccgaacagc 2278441 agcaaatcac cttcagcagc atcaagtgct tcaatcagct tagactgctt ttcttcatca 2278501 aagaatttag cgatcgggcc tttcactccg tctgcctcaa ccttcaccca ggcaagccct 2278561 tttgccccgt agtttgcagc aaaagcgcca agagcgtcga tgtcttttct ggagtaatcg 2278621 ccggcaccgc cttttacatt gatggctttg accacgccgc cgtttgctac agctgatgag 2278681 aacactttaa attccgtatc ctttacaatg tcagacacat ccgtcaaaag catgtcaaaa 2278741 cgcgtatccg gtttatcaga cccgtacttg ttcattgctt cgtcatacgt cattcgagga 2278801 agaggaagct gaagttcctc accttttgtt tcacgcataa cctttgccat catctcctca 2278861 gccaatgaca taatgtcttc ctggctcata aaggacattt caatatcaat ttgcgtaaac 2278921 tcaggctgac ggtccgcacg caagtcttca tcgcggaaac agcgggcaat ttgataatat 2278981 cgttcaatgc ctgataccat cagaagctgt ttaaatagct gcggagactg cggcagcgcg 2279041 tagaactcac cttcgtgcac acggctcggc accaagtagt cacgtgcgcc ttcaggcgtg 2279101 cttcctgtta aaatcggcgt ttcaatatca agaaacccat tttcatctaa aaagctgcga 2279161 acagctttcg tcacgttatg gcgcagctgc atcgtctgga acatagccgg tctgcgcaaa 2279221 tctaagtaac ggtgttttaa acgaacgtcc tctgacactt cttcagcttg atcagaaatc 2279281 gcaaatggag gtgtctttgc agcatttaat acgttcactc catcagcatg tatttcgatc 2279341 gcgcctgttt tcaaattcgg attaactgtt ccctcttcac gcgccaccac ttttccttga 2279401 atatcaagca cgtattcatt tctgatgcct tccgcaatag caagcgcttc ttttgacaca 2279461 tcagggttaa aaacgacttg aacaatgccc gtacggtcac gcaagtcaat aaaaatcaat 2279521 ccgccgaggt ctcgtctttt ttggacccag cctttcagcg ttacagattc gccaattgct 2279581 ttttcagtta tatcaccgca ataatatgtt cttccaaaca atgcgtttca ctccttatcc 2279641 cttttggttt gccttcatca catgtataaa ttcatcaagt gccacttcaa tctgttcgcc 2279701 cgtctgtgca tcctttacat tgattttgtt ttgggcaagc tcatcttcac ccaaaatcgc 2279761 aataaatctg gcctttaagc gatcagctgt tttaaactgg cctttcattt tcttattttc 2279821 ataatcgatt tcactggaaa tgcctgcttc tctcagtttg tacaccaatg aaacagaata 2279881 atcctttgct ttttcgccga gtgtgacgat atagcagtcg attcccttat caacaggcag 2279941 ctctcttttt tcagcatcaa ttgcggcaag caagcgttcg atgctcatcg caaatccgat 2280001 gcccggtgct tcaggtccgc cgatctgttc gacaagcccg tcgtagcgtc cgccgccggc 2280061 aagtgtcgta atcgcgccaa agccctccgc attgctcata atttcaaatg cggtgtggtt 2280121 gtaataatcc agccctctca caaggttcgg atcgatttca tacgaaatgc caagatcatt 2280181 taagtattgt ttcacttttt caaaataagc ggctgattct tcatttaaat atgtcaaaat 2280241 cgaaggtgcc gatttcatca gctcatgatc acggtctttt ttgcagtcca aaattctaag 2280301 cgggttcgtg tgcagccggg actggcagtc tgaacaaaat tcttcgatgc gaggctcgaa 2280361 gtgtttcacg agcgcttctc tgtagctttt gcggctatct tgatcgccga gactgtttat 2280421 gacaagctta acgttttcta aacctgcttt ttcataaata ctcatcgcaa gcgccattac 2280481 ttcagcgtcg attgcagggt ctttcgaacc aatcgcttca attccaaact gataaaactg 2280541 gcggtaacgg cccgtctgag gacgttcata acggaacatc ggcccgacat aataaagctt 2280601 tgtcggctgt acaggatttg cgaacagctt gttttcatta aaagcgcgaa ccgcagcagc 2280661 tgttccctcc ggacgaagcg tcaggcttct gcctttgcgg tcctcgaagg tatacatttc 2280721 tttttgtacg atatccgttg attctccgac gcctctggca aacagttctg tatgctcaaa 2280781 aatcggtgtg cggatttctt tatattgata agtgcggcaa gtgtctctca taatttgttc 2280841 aacaaactgc cagcgatctg attctccagg cagaatatcc tgtgttcctc tcggaatgtt 2280901 atatcccata ggtagacctc cttatgtatt ccttataaaa tatccaatga tcgttaatga 2280961 tgaaaatgaa aaaaactccc gcccctacta tacatgatag tagggacgag agttataccc 2281021 gtggtgccac cctagttgga atacgttcat attcccgctc gatcctttaa cgcaggttca 2281081 cgttcactgc ctaatggcgt tattcacgcg ttcagcagga aacctccgga gtgttgtttc 2281141 gagaaagacg caatgggatc cgctttcagc ctggggcggg ttcctctcta atcatgcaat 2281201 ctgacctact cttctccatt attggttcaa atctttcatc atttgctatg tactcaattt 2281261 ctattataat aatgggattg gggttctctg tcaagcttta ttccggttgt ttttcctcag 2281321 cgctgcttct ttggacataa gaccaaattc agatgctgtt tccgtaagat aaccagtcgt 2281381 atcgggatct gcgtgatcgc tgtaatgcag attcgcttca ccgtcgtgaa atgcacgtcc 2281441 catttttgga tgatatttca tgatttgcac acctttttga ttgtatttac gcttagtata 2281501 aacaaatcat tttattttta tttaaaaatc agaaaggact ttacgatatt aaacaagaat 2281561 gcttttttaa tgatcatcag aaaggaggac acaatgaaca agaaatactt tgtccttatt 2281621 gtatgtatta ttttcacctc agcgctattc ccgacctttt catccgttac agctgctcaa 2281681 ggagaagcgg tcatcgcaac agatgaaatg aacgtcagaa gcggcccagg gcttagctac 2281741 ggcattacag cggaagtaaa aaagggagaa cgctatccaa ttttaaagga agatggagac 2281801 tgggtgcaga tacagcttgg ttctggagaa aagggctggg tagtctcctg gcttattaca 2281861 aaggaagacc aggccagcac aagctcctca ggaagcagtg acactgtgac atcaacagac 2281921 cccgatctgc ggatgagaag cggcccgggc acttcctacg aagtcatcgg caaattcccg 2281981 caaggcagcc aagcatctgt cattgataaa gattcgggct ggatcaagat atcctatcac 2282041 agtgccaccg gatgggtatc atctgaatat gtcacatcag gaggcagcag ttcagcgtct 2282101 gatgagagtg accaaaccga ggattccggt gcgtcaacga cgggcacagt cggtgtttct 2282161 tcgctaaatg taagagcctc cgcctcacat gacgcggcaa ttataacaaa acttgatcgc 2282221 ggaacgaaac tgacggttct caacgagaaa aatggctggg ctcacattga ggtgaacggg 2282281 ctaaaaggct gggttgcaag ccattacctt ttgactagtt ctgttccagc tgatgattca 2282341 gcaaatgccg gcagttcatc ctccgctaaa aaagcctata tcatgtacgg aggaacgaat 2282401 ctaagaagtg atgcgtcaac atcagcttcg atcgttgagc gcgctgccaa aggagattca 2282461 tacaccatta ccggttcaaa gggaagctgg tatgaaataa agcttgataa cgggcagact 2282521 gcttatgtag ccaattgggt ggtccaaacg tctaaaagcg cagaagaagc aggtgaaccg 2282581 ccagtctctg attccccgtc tggaaacggc tctctaaaca ataaaacgat tattgttgac 2282641 ccgggacatg gaggaaaaga cagcggaacg atcgggtatt cggggaaatt cgagaaaaac 2282701 ctgacgatca aaacggcaaa actgctcgcc agcaaactta gatcggctgg agcggatgta 2282761 tatgtgacac gccaggatga tacctttgtc agcctgcagt cacgggtctc tacctctcac 2282821 taccgtaacg ctgacgcctt tatcagcatt cattatgaca gctatgcgga tacctctaca 2282881 agaggcagta cagcatatta ctacagtcct gccaaagatc aggaactcgc atcagatgtc 2282941 cactcagaag tggtgaagcg ttcttccatt ccagaccgcg gcgtattatt cggagattat 2283001 tatgtgctcc gggaaaacag acagcccgct atgctgtacg agctgggata tgtaagccat 2283061 ccgcaggaag aagccattgt acatagcaat tcataccaag aaaaagtaac agatgggatc 2283121 gaaagcggat tagagaaata cttccaataa aaaaagctgc cttttggcag ctttttttat 2283181 tttgaatcca taatgagcgt gaccggtccg gagtttgtaa gctgaacatc catcattgct 2283241 ccaaacgttc cggtctccac tttgattcct ttttcacgaa gcaggtcatt ccatttttca 2283301 taaagaccta aagctttatc aggtttggcc gcgttcatgt agttcggccg gcgccctttt 2283361 ttcgtatctc cataaagcgt aaactgtgag acggataaaa tctctcctcc tatatctaca 2283421 agagacagat tcattttccc ttcactgtca tcgaaaatac ggagattgac aactttatcg 2283481 gctaaataag ctgcatcatc ttctgtatca tcgtgagtga tgccgaccag caccataagg 2283541 ccttgtccaa tttggccgac gacctcttcg tccactgtaa cgcttgcttc tgttactcgc 2283601 tgaacaacta atctcttttc taaccccttt agttcatgac gcggcgcaca gaatagatat 2283661 ctctaatctg tttaatacgc tcgacgactt tatgcaagtg attgatattc tggataaaaa 2283721 tcgccatatg gatggttgcc actttattgc gatccgattt gccagagaca gatgaaatat 2283781 tggttttcgt ttcattcact gcctggagta cctcgttcag caatccgcgg cggtcatacc 2283841 caagaatctc tatctcaaca ttgtattcct tgcgcttttg aacttgtgac tcatgttccc 2283901 actctaccgg gatcagccgc tcttgggctt cattcgtttt gacattcgga cagtcttcgc 2283961 gatggaccga aacccctctg ccttttgtga taaagccgac aatatcatca cctggcacag 2284021 gattgcagca ttttgataaa cggacaagga ggttgtcaat gcccttgaca cgaacgccag 2284081 cttcccgttt tcttccttgc gggtatggct taggttcccc agtgacttcc tgaacgatct 2284141 tttcctgttc ttcctggtcg cgctgctttc tctctttttc tgttaggcgg ttcgccacct 2284201 gcagagctgt gatgccgttg taaccgaccg ccgcgtacat atcctcttca tttgagaaat 2284261 taaatttgtc agcaaccttt tgaatattct ccggcgttaa aacatccttc aattcaaaat 2284321 ccaagttttt aatttctttt tcgaccagct cacggccttt ttcgacattt tcttcacgcc 2284381 gctgtttctt aaagaattga cggattttat gcttcgcttg ggatgtttgg gcaagcttca 2284441 cccaatcctg gctcggaccg taggaatgct tagaggtgag aatttcaacg atatcacctg 2284501 tccgaagctt atggtcaagc gtaaccattt ttccgtttac tttggcaccg attgttttat 2284561 tgccgatttc agagtgaatc cggtaagaaa agtcaatcgg aacagaaccg gacggaagct 2284621 cgattacatc tccttttggc gtaaagacat acaccatgtc agagaacaaa tcaattttga 2284681 gcgattccat aaattcttct gcatctgtcg attcattttg aaattctaaa atttcacgga 2284741 accaagaaag ctttttctca aaggttgcac cttcattggc tgctttccct tctttataag 2284801 cccagtgagc cgcaaccccg tattccgcta tttcatgcat ttcaaaggtg cggatctgca 2284861 cttcaagcgg atcgccttta ggcccaataa ccgttgtatg aagcgattga tacatattcg 2284921 gcttcggcat tgcgatataa tctttgaatc tgcctggcat cggtttccag catgtgtgaa 2284981 tgatgccaag caccgcgtag cagtccttta tgctattcac aagaatacgg acagccaaca 2285041 aatcgtaaat ttcattgaat tgcttatttt gcagcaccat ttttcgataa atgctgtaaa 2285101 tatgtttcgg gcgtcccgag aagtcagcct tgatatttac ttcttcgaca cgtttcttca 2285161 cttcattgac aacctcatcg acataaagct ctcgttctgc acgtttcttc ttcatgaggt 2285221 tgacaattct gtaatattgc tgagggttca aataacggag cgccgtatct tccaattccc 2285281 acttaatttt tgaaatcccg agacgatgcg ccaaaggagc aaaaatttcc agcgtttcat 2285341 tggagattct ccgctgtttt tcctgaggca gatgtttcag tgtccgcata ttgtgaagac 2285401 gatccgccag cttgatcaat atgaccctga tatcttgagc catagcgaca aacattttgc 2285461 gatgattttc cgcctgctgt tcctcttgag atttatattt aattttgccg agtttcgtta 2285521 cgccgtctac aagcattgcc acttcttcgg aaaatgcttc tttcaggtca tcgagcgtca 2285581 catctgtatc ttccacgaca tcgtgcaaaa atccgcccgc gattgtggaa gggtccattt 2285641 caagatcaac gagtatcccc gcaacctgaa tcggatgaat aatatatggc tcgcccgatt 2285701 tgcggtattg ctcgcgatga gcatcttcag cgtacagata tgctttttcg acaaatgcga 2285761 tatgctcatc agatagatag ctgcgtgctt tatctataac ttgctcggca gtcaatactt 2285821 gttcgttcgc catggaatca ccttttttaa aatgtaaact gtattgtagt ttattatcaa 2285881 gaaaaaaacg aaagatgtaa agagcagaag ttcaaatagc caaatattat ataaaataaa 2285941 tgcaaaacaa taggaaaaaa gcaccctgac atggagtgct ttttcgttat gcggttatcc 2286001 ttagtatttc atcaatgtta agatgtcgta atcttcgagc ttatttctgc cgtcaaggta 2286061 agaaagctcg attaagaaag cgataccagc aacaacgccg ccaagttctt caacaagttt 2286121 gattgtcgct tcaattgtgc cgcctgtcgc aagcaggtca tctgtaataa gcacacgctg 2286181 accaggctta atcgcatctt tgtggatcgt taatacgtct tttccgtatt ccaagccata 2286241 atccactttg attacttcac gaggcaactt gccttctttg cggaccggcg caaaacctac 2286301 gccaagcgcg taagcaacgg gacagccgat aataaagccg cgcgcttcag ggccaacgac 2286361 caaatcaatt tgcttttctt tcgcatattc aacaatttga tctgtggcat agcggtatac 2286421 atcgccttta tccatcagtg tcgtaatatc tttaaattgc acgccctctt tcgggtaatc 2286481 cggtacaatt gttacgtatt gttttaaatc catctgtttt atgtcctcct cgtactttca 2286541 taagcctctg aatcttgttt catcagctta ttcagccatt ccttcagctc ttcagcagaa 2286601 gaataattca gcttttgatc cagttccatc agctgctgtt tcgcctgata tgtttgtgag 2286661 tctgttaagt cgcgtttctt tgctccgctc acaacagaca gcacaccatt ctctatttta 2286721 acaaaaccga gatcaaaaaa cacctttgtc atgaaattga ttgtttcaac ggaccagcct 2286781 ttatgttttg caagctctga accgtgtttt ttcacgtcaa aagcgcctct tttcagcaag 2286841 aacgcataat accatttaaa gtggtctctt gcgggaaaag ttgataaaaa gtggtcctca 2286901 tgattgagaa aaataaaata tatccgctcg ggcgcctttc cttccagcaa acgtgcgagc 2286961 atgtccagcg aaggcggcgg atccagtaat acaatatatg caccatcgag gtcaaacgcc 2287021 tttgcttgat ctttagaact gatgacgtgc acttctcggc gaaggtcttc agtttgaagt 2287081 aatgttgttg agtcttcttt gaaagagaca atggcccgtt tagcagatgg aagggcggaa 2287141 actgtgtctt cccacgtccg ttttcccctt aaatcaaaca gctgccattc agaaacagcg 2287201 gcatccttta tcataagctg cggctttttt cgattgttcc attcgttgat tgacatctca 2287261 ccgacaatgg aaattcttga acccggtacg atgccttctt gaagctcgcc tttattaaaa 2287321 ccgacgcaat caagctggga cgactcgttt ctgatcgtca ttttgacatg agttttattt 2287381 gcccctatct tgcggacatc ttccagtact gcattttcta cgagaacgtg cggtttcggg 2287441 ttcagcatgc caaaaggaga cagcatgttc atttctgcga tgctttcaac tgtaatgtct 2287501 tcgacgccgc agacaaggtc gacttcctgt acgggaataa aatcctcttc cgtaagcgta 2287561 ttgtccgcta tttcattcag cctgcttcgc aaatccggca catcttcggc tttcagcgtc 2287621 atccccgcag ccattggatg gccgccgaaa tgaggaagaa tatctctgca ttcagaaagg 2287681 ctctcaaata aattaaatcc tctgatgctt cgggccgaac ctttagcgat tcccttttct 2287741 tcatcaatac caagaacaat ggccggtcgg tagaaacggt ccacaagctt tgaagccaca 2287801 atcccgacga ctcccgggtt ccatccggct ttggccacga caattgcagt ttgatcgagc 2287861 ccttgctgtt caaccatttc aatcgcttca tccgtcattt tgctgaccat tttttggcgc 2287921 tctttgttca gctggtcaat ttctgcggca agctcttccg cttcaaacga atcctctgac 2287981 ataagcaaat gaacagcggg atccgcctgt tcgattcttc cgacggcatt cagccttggt 2288041 gcgagctgaa atccgactgt ttcttcgttc gcttctccga tgtctccgcc tgacagctta 2288101 atcagctctt ttaagccgag ccgatttgtc cgtcgaagcc tttcaagtcc tagtgttgct 2288161 attaatctgt tttcgtcatg cagcgggact agatcggcaa tggtgccgat agccgccagg 2288221 tcaagcagtt catcaggaag ttcacccaat aaagcgtggg caagcttaaa cgcgactcca 2288281 accccggcaa gctctttaaa cgggtaagtg cagccaggct gcttcgggtg gacgatcgca 2288341 cggacatccg gaagctccgg tcccggttca tgatgatcgg taatgatgac atccagtccg 2288401 agttcctttg ccaccttcgc ttcatgcaca gcggcaattc ctgtatcaac cgtaatgatc 2288461 aaagagaagc cccgttcttt aatcgaacga aacgcctgtt cattaggtcc atatccttct 2288521 ttaaaacggt caggtatata aaaatcaact tgagccgaca gtttttgcag cgtgtgaagc 2288581 atcactgacg tacttgtaac cccatcggcg tcataatcgc catatatcat aatcttttct 2288641 tgttgtgaaa tcgcctgttt tattcgatct gccgcttctt tcatgccttt catttcaaaa 2288701 ggatcataaa aatcggcatc ctttgtatgt aaaaacagcc tagcgctttc tgccgtatca 2288761 aagcctcttt ttacaagcag ggacgcaaca agaggtgtta tatgcaattg ttctgtgagt 2288821 gatttgacct tatcctgatc tggtcgctgg atttcccatc gcatttttga cgctaacata 2288881 aattcacccc tcaaccaccc tattatacta gagcaggctg aggggtttca aataatattc 2288941 gaaaactagt cttttttctc aatcatggct gatgcatcct gtgtgtcagt ctgatcagca 2289001 agatgagtat cctcttgttt atgtattgct gttctatttt ctttccgcaa ggtttttatt 2289061 tcccgcttca atttcattac ctgaaaaatg ccgacagaaa atacgatcag tgctcccatt 2289121 aaaactgagc ccaaaataac aagaatgagc ggccattctg atcttccaaa caggtaatca 2289181 acttctacgg atcgaacatt aatgactgcg aaaatagcga caattaaggt gaaaataagt 2289241 gcgaaaataa tggtccattg tttattcatt ctcttttccc ccaaacttct tattgaggta 2289301 actttcccaa tcaagactgg ttttaaacat ggcttaacac taggttaagc tccctttgct 2289361 gttaattttt cccggatcag cctcttcagt ccggttccct caccggaaat cacaagtgta 2289421 tcgccttcgt caatgactgt ttcagagctc ggattcagtt gtttatcctg attcttttta 2289481 acaattgcaa tgaccgtcac atgatattcc tgacccacat tcaaatcacc aatcgtctga 2289541 tgaatggcag gcgctcccgc ctctgcttta caccactcta taatcaaatc atcaagggct 2289601 gactcgacct gttctaatgc tttcggttta tatgccattc cgccaagaat tgcagacatt 2289661 tgccttgctt cagcgtcatc aaactgcacg gaggcaacac attcctcatg gtcgttttcg 2289721 tcaaaatagt aaagctctct ccgtccgtca tgatgaatga taattgaaat tttatcacgg 2289781 tttctagtaa tcatttcaac tttttgtcct atgcccggca gctctgattc gcgaaccctc 2289841 atatataaac cctcctacat atctgaaaac cagccataaa cacttttaac accatatata 2289901 tgtttaaatg taagcgtatg tcattatagc aaatgtctat tttaagttca atgaaacttc 2289961 aaaaaacagg ctgccctgca gaggacagcc tgatattttt tattgcgccg aatctttttt 2290021 cagttctctt cctttccatg caagccaaat ttgtgcggca atgtatagag aagaataaac 2290081 gcctgttaac agcccgacca ataaagcaat tgagaagtta gtaatagaag atgctccaaa 2290141 gatcagcaat gtcacaacaa caatcacaac ggttaataca gtgttaattg aacgtgtaaa 2290201 ggtttgctgc aggctcaggt ttacaatatg gttcagatcg gcaaaggttt tcggcttacg 2290261 ctttttcata tgctcgcgga ccctgtcaaa tgtaacgatt gtatcgttaa tggaataccc 2290321 gattatcgtc aagatggccg cgatgaatgt aacatctacc tcaagccttg taatactgaa 2290381 gaacgtgacg ataaagaatg cgtcatatag caatgaggcg atggcagcaa tcgccatttt 2290441 gtattcgaat cggattgaaa cgtaaataat gatgccaata gaagctatag caactgcgta 2290501 cagcgcattt ctcgccagct ccttaccgac tgtcggtgaa actgtgctga catttggatc 2290561 agatccgtat ttgtctttaa aatacgtttt tacttttgca atggtttctt tatctggcac 2290621 cccgacaaaa cgggcaacac cgatattgct cttttcgcct gacagaacta cagtatcagg 2290681 gtccataccc agagattcaa aatccttctc aacttgctct gtcgtcagct tatggtcgct 2290741 ttgcacttca atccgtgcac cgcttgcaaa gtcaatgcca agattcagcc tgaacacaag 2290801 caggataata atcccggcaa ccgtgaccgc actggagaaa ataaagaagt atttgcgttt 2290861 gctcgtgaaa tcccattttt ggaatggcgt atgcggctct gtattttcat ccgtatcctg 2290921 aatatccatg atatgtttct tattgacacc aaaccagcct tttttccgat caagccatct 2290981 gctttccaca aggagagcga ggagaaatct cgataagaaa acggcagtga taaagcttgt 2291041 caaaatcgat aggatcagca ttgtcgcaaa ccctttaaca gagcttgtcc caaagataaa 2291101 gagcacaacc gctgcaataa tggttgtaat attcgcgtca aaaatcgtcg caaatgaccg 2291161 tctgtttcct gaacggaagg cagagcggac tgactttcct agcttgagct cttctttaat 2291221 ccgctcatag gtaataatgt tggcgtcaac agccatcccg acacctaaaa tgagagcggc 2291281 aattcccgga agcgtgagta cggcattcat ccagtcaaag atctggagtg taatgtagat 2291341 ataaacagac agcgtaatca ccgcgattaa tcccggcaga cggtaataga aaagcataaa 2291401 taagaaaata attgcgatac cgacaatacc ggcaaacacc gtatcatgga gagcctgctg 2291461 gccgaattgc gcgcctactg atgtcgaata cttttcagtc agtttcacag gaagtgcgcc 2291521 tgcgtttaaa atgctggcta aatctttcgc ttcttgagct gtgaaatgac cttcaatttt 2291581 tacatcagtt gtatttagtt cctgacttac atttggagcg gatacaaatt taggatgctc 2291641 tttttgaact tctttcttaa aggaatcacc tttatcataa tccaaccaaa tgacaagctg 2291701 gttgtttggc gccattttca tgaccttctt ggtcacttca ccaaatttat cagcgtcttt 2291761 cagcttaatc gtgacaattg gctcatttgt tgtgctatca taagtttgtt tagcgccgtt 2291821 ttcgactaga tcagcaccgt ttaacagttc cttatcattt gcatctctga aagaaagctg 2291881 cgcttcagtc gccaaaattt cacgcgctct gttttggttt gtcacgccag cgagctgaac 2291941 gcgaatccgg ttattccctt caatttggat gttcggttcg ctgacaccga gaacattggc 2292001 ccggcggttc agtgcctcta ctgtgctgac cagaacgtct tttgtgattt tgtcaccttt 2292061 ttttacaggc tgtacatcat acagcacctc aaatccgcct tgcaaatcca atcctaacgt 2292121 aatattgtta gcggcaggct tcgtaaagta gcccaagccc gtgccgatca atagaacgaa 2292181 aaggaaaaac gcaatcaagc gtcctttttt cattatgtat atcctccctt aaacctgtgc 2292241 gaatcaacct gctatctcag cagttcttcc aatgcttcct ggccctcttc actgcccagc 2292301 caattagacg ttttaaatga ctcaacggtt gcatagttca taaattcgcc aattttcact 2292361 gataaaatat cactcgccag ttcataaatg ctcagttccg ttttcttttt ccacttctta 2292421 tctgttaagt atgaccacaa actttcgagt tcaacatcat catacccgag aatcttaaac 2292481 tcttccagtt tgctgtaaag aaacggcctg acgtggtctt tatatagatc ggctggatgc 2292541 ttctccacga attccacgct ccttttttat tgtttttcaa gaagacttgt catgcttgga 2292601 cgacatatac gcatatcttt attgtatatg attccaggta gtttgagaag gcagggggta 2292661 aaaatggcga aacagacgtt tttaaagggc actcttatcc ttatcgcagc aggaatggtt 2292721 acaagaatgc tcgggtttgt caaccgggtg gttatcgccc gttttatcgg tgaagaagga 2292781 gtcgggcttt acatgatggc agcgcctact ttcttcttgg ccactacatt aactcaattc 2292841 ggtctgccgg tcgcgatcag caagctagtc gctgaagcca gtgcgcgcgg agatcatcaa 2292901 aaaacgaaaa atattttagt catgtctctg accattacgg gagtgctcag cctcatcttt 2292961 acaccgctgt ttctgttttt cgcccctgtt atggctgaaa cgatgctgac agataagcga 2293021 acactgtatc cgctcttggc cattacgcct gttgtgccga ttattgctat atcgagtgtg 2293081 ctgaggggat actttcaagg aaaacagaat atgaacccgc ttgctatgtc acaagtcctt 2293141 gaacaggttg tccgcatttc actcgtggct gtctgcacaa cgatttttct cccttacgga 2293201 attgaatatg ctgcagcggg ggcaatgcta tcctcagtgg caggggagct ggcatcactt 2293261 ctttatttat tcgtttgctt taagtataaa aagacaatta aaatcagaaa gcatttttta 2293321 cagtcaatta aaaacggaaa acaaaccttt acccaattaa tgagcgtgtc ccttccaaca 2293381 accgggagcc gctttatcgg aaacctctct tggtttttcg agccaatcgt cgtcgctcaa 2293441 agccttgcca tcgccggtgt ggcaacagtt gccgcaacaa agcaatacgg ggaactaacc 2293501 ggctttgcca tgacgctgct gactctgccc agctttatta catattcttt gtcgaccgcg 2293561 cttgttcctg cgatcagtga aggaatggag cagaaaaaat tgcaggtggt ggaataccgc 2293621 ttagaacagg cgatgcgtct ctgtctgctc agcggaggca tttcagttgt tattttattt 2293681 gtatttgcgg atgagctgat gagagtgatg tacggttcct caggcgcagc tgtatttata 2293741 aaagtgatgg ccccgttttt tctgctttat tatttccaag gcccgcttca agctgtgctg 2293801 caggcgctta atttggcagg agctgcgatg atgaacagct taatcggagc gcttgtcaaa 2293861 acaggcctta tttttgtcct tgccacaagg ccttctcttg gcattatggg cgcggcatta 2293921 gccattgtga caggcatggt gctcgtcacg ctattgcacg cagcaaccgt aagcaaagtg 2293981 ctgccgatca gcatcaaaat caaggagtac gcgctcagct tcgctgttat tgtaatttgc 2294041 ggattcatca gctccgccat caaacaatat ataagctttg gagcatctga ggctgtcaat 2294101 ctagccggat ggattgcggc gagcgccgcc atttatatga tcctcctgct cgttttccgt 2294161 ttaattaaaa aagatgagct tcgccgcatt cccattatcg gacggttgat catccgataa 2294221 tggtcacgtg cggtgcccat ctttttcatc aatatatatt tctccgtctg taaacgagca 2294281 aaatgaaata tctgaagggt ttgtgtatcc gtgtttttgc aaactttcaa gcagccattt 2294341 tctatcttta ctgattctgg acaggttttc tgtttgaatg aagccgtcta taatgagcgg 2294401 catttcgagc tgccgatgct ctccgctgtt ttctttctta acaatagtca gtttgcccga 2294461 cggctctaaa atagcaaatg atacgtcagc tactctgtcg atgctatttt ctctgagctg 2294521 aaccattaaa tcatcaaaat tataacgctg tgatttcatg gcttcttcgt caatttttcc 2294581 atatttgata attatggtcg gcttaccgtc aagaagctgg cggacttttc ggttttttaa 2294641 agaaaagtat gccaaagtca cttgaatgat cattaataca agcattggca aaatggtatg 2294701 aaatagatga tcgtctacgt tttctatggc taaaacggca atttcagcca tcatgataaa 2294761 gacaacgaga tctaaaatac taagctctcc gatctcccgt ttgcccatga aacgaaaaat 2294821 gaccaatatc acaaaataca atacgactgt gcgaaacgca atagtgagaa gctcttccat 2294881 tatgcacctc caactcatta taggttgcaa caaaatgatc aatttatgta agaaaaaccg 2294941 attgcatttc acaaagcttt tacgtctaat tcatgggata agggaataca tttttacaaa 2295001 gacgagccat cagcatgtct gacggttttg aacaaaaaga acagaagcct tttaatacag 2295061 gcagagagga gacaatcatg gaggaaacga aacaagttgg aaaaggcatt ctttacggct 2295121 taatcgccat attttcagcc atgctcctga caagtttagc ggtttcactt ttattgaccg 2295181 caacctcgct ggaagaatca tcatttaact ggctgatcac cgctatctca tttctctctt 2295241 tatttatcgg cgggttcatt tcaggcggga aaggcaagga aagaggctgg atgattggcg 2295301 cattgaccgc cttaagtttt tctctgatta tcttattgtt tcagtattta ggattcggaa 2295361 agacatttac agcagaacag ctgatcttcc atctgggatt tttaggggtg tgcatgctgg 2295421 gcgggatttt cggcgtgaac atgaggggaa acaggtcttc cacataaaaa agagcgggct 2295481 cacttgcccg ctcttttttg tttgctatgt atagctcctg ctgttattca gcagcagaaa 2295541 cttctctgat cgcgcggcgg tcgaacgtaa gacgtgtgtt atcaccagtc ttaattacga 2295601 ctttgctttc gtcgatagag tcaacagtac cgtgcaatcc cccgattgtc actactgaat 2295661 cgcctttttt cagttcctct tgcatttggc gtacagcctt ttgctgcttt tgctgaggac 2295721 gaatcagcaa gaagtaaagg accgcaaaca ttaaaataat aggaaccaat gtacctaaag 2295781 tgccagtcat cattttcacc cctttctgta agcctgttat gtttatttag aagcttttcg 2295841 catttggctt gttatagccg taacgctcaa agaactcttc tctgaaatca cccagacgat 2295901 cctcgcgaat agcctgtctt acctgctcca ttaagtgtaa cagaaaatga aggttatggt 2295961 aagttgttaa tcgaaggccg aatgtttcat tgcagcgaat caagtgccta atgtacgcgc 2296021 gagtgtagtt tttacatgta tagcaatcac actcttcatc aatcggacgg aagtctcttt 2296081 caaatttcgc atttttcata ttgagtcgtc cttcagcagt aaacactgtg ccgtttcttg 2296141 caatccgtgt aggcagcaca cagtcaaaca tatcgacccc gcggatcgct ccgtcgatca 2296201 gtgcgtccgg agaacctact cccatcagat atctcggttt atccttcggc aagagcggtg 2296261 ttgtgaattc gagtacacgg ttcatgacat ccttcggttc acctacagac aatccgccta 2296321 tagcatatcc cggaaaatca agcgaaatca agtccttcgc actttgtgtc cgcagatctt 2296381 catattctcc gccttgtaca ataccaaaca gcccttgttc atcctgacga ttgtgggcat 2296441 tcaggcagcg ttccgcccag cggcttgtcc gttcaactga cctcttcatg tagtcgtact 2296501 ccgccgggta tggcgggcat tcgtcaaacg ccatcataat atcagagccg agtgcgtttt 2296561 ggatctccat cgctttttcc ggagataaaa acagcttgtc tccatttaga tgattgcgga 2296621 aatggacacc ctcttcctct atattacgaa acttgcttaa agaaaagacc tgaaaaccgc 2296681 ctgaatctgt taaaattgcg cggtcccagt tcataaattt atggagcccg cccgcttctt 2296741 tgacaatgtc ttggcccgga cgaagccata gatgataagt gttgctcaaa atgatgcctg 2296801 catccattgc tttcagctct tcaggcgaca ttgttttgac tgtcgccagt gtgccgaccg 2296861 gcataaaaac cggcgtttcg aaggagccgt gaggcgtatg cactttgccc agccgcgctc 2296921 ctgtttgttt gcattctttt ataaattcat agcgtattgg ttgttcagcc acttttgatg 2296981 aggcctcctg ttctcaaatt atataatcag catcgcgtct ccgaagctga agaaacggta 2297041 ttcctcttcc actgcatggt tataggcacg cagaatgttt tctcttccag caagcgcgct 2297101 gaccagcata atcaatgacg atttcggcaa atggaagttt gtaatcattc cgtcaatggc 2297161 tttaaattca tagcccggat aaataaaaat agatgtccag ccgcttgatg ctttaaattg 2297221 cccgtcatgt tctccggcaa tcgtctcaag cgtgcgtgtc gaggtcgtgc cgacagaaat 2297281 gatccgaccg ccattttctc ttactttgtt taaggctgca gccgtttctt ctgacatttg 2297341 ataaaactct gcatgcatat tatgctcttc cacttcatcg gcactcacag ggcgaaacgt 2297401 tccaaggcct acgtgcagtg tgatgaactc aatttgcacg cctttgtctt tcagctgctg 2297461 taagatttct tccgtgaagt gaaggccagc tgtaggcgca gcagcagagc caatttcttt 2297521 tgaatacact gtctggtagc gctctttgtc atcaagctgt tctttgatat atggagggag 2297581 cggcatctct ccaagggatt caagcacctc gtagaaaata ccgtcatatt gaaattccat 2297641 ctttctgccg ccgtgctcaa gctcttccgt gcagattgcc ttcaatcttc cgtctccaaa 2297701 tgtgacaaca gttccttttt tcacccgttt cgccggtttg gcaagtgttt cccatttatc 2297761 accggtttcc tgtttcaaca aaagaagttc cactttcgcg ccggtatcct cttttgtgcc 2297821 gaataaccgc gcaggcagta cccgggtatt gttcaggact agacaatcgc cttcgttaaa 2297881 gaagctgata atgtgtttaa acgagctgtc agtaagctct cctgtatgtt tatcgagcac 2297941 catcagcctt gaagcatcac gctgctccaa cggtacttgt gcaattaaac gttctggtag 2298001 ttcaaaatca aataaatcga ctttcatgat gatttcacct ttattctagt cttttgttat 2298061 ttcattctgc caaaaagatt aagcaaaatt gataatacca cacttataat aatacaagtg 2298121 acaaccggga agaaaaacgt aacatttcct ttttttacaa aaatatctcc cggcatcttg 2298181 ccgacaaaat gcaaaactgc tccgataata agcaaaacag caccaagaat cataatgatc 2298241 ttaggaaatt cagtcatatc ggggagcctc catttggaaa tgatgataaa cggccggtgt 2298301 cacgatcctt ccacgcggcg ttctttgtat aaatccaatt tgcagcagat atggttcata 2298361 tacgtcttca atcgtatgcg attcctcgcc gatggtagct gaaatcgtat caaggcctac 2298421 tgggccgccg ttgaattttt cgatcatgcc catcagcagc ttatgatcaa tatgatccaa 2298481 accgaggcgg tcaacctgaa gccgctccag cgcattctga gaaatgtctt ccgtaatcct 2298541 gctgtcaccc agcacttggg cgaaatcgcg cacccttctc agcaggcggt tcgccacgcg 2298601 gggcgtccct ctcgatcttc ttgcaatttc aagagccgac ggtttatcaa tctcaacctc 2298661 gaatacatca gcggttcttg tgacaatatc cgccagttct tcttgtgtat agtactcaag 2298721 gcgagacatt acgccgaatc tgtctcttaa aggagccgtc aaaagcccca ccctcgtcgt 2298781 ggctcccacc agcgtaaaag gcggaaggtc gaggcgaacc gagcgggcag atgggccttt 2298841 gccaatcaca atgtccaggc aaaagtcttc cattgcagga taaagcacct cttcgatcga 2298901 tctgtgcagc ctatgtattt catcaataaa taatacatct cccggttcca gcgccgttaa 2298961 tatagcagcc aaatcaccag gcctttcaat cgcaggccct gatgtcgtcc gcaattccac 2299021 tcccatttca ttagcaacaa tcgaagcaag cgttgttttt ccgagtccgg gcggcccgta 2299081 cagaagaaca tgatccagcg tctcctgtct cattttcgcc gcatctataa acacgcgcaa 2299141 attttctttt accttatgct gcccgatata ctgtgccaga ttttgcggcc tcaggctttg 2299201 ctctatcact gattcatggt tgtctgcttc acttgagacg agccgttcat ccatgaacat 2299261 caccttactt taatagtttt tgtaatgctt ttttcacata ttggtctgtt gtcagcccaa 2299321 tttcttcttt aaggtgagga agcacctttt tgatttcttt ttcagcatat ccgagaaccc 2299381 tgagggcttc aagtgcttct tcaagagccg tttccgctgt ttgcttttca agcctttctt 2299441 catgattaaa cagattttca atcatttcag gcacaacatc tgccagcttt ccttttaaat 2299501 ctagaataat ctggcgtgcg gttttctttc ctactccagg aaacttgacc aaaaaagctt 2299561 catcttcatt ttcaattgct tggatgaccg ctccgggatc acccgagccc aagatggcaa 2299621 gtgctccttt cgggccaatt ccggtcacgt ttaacagctt tgtaaagagc gccttctcct 2299681 ctcttgttga aaaaccataa agcgaaaaag catcctctct gatatgatgg tatgtaaaaa 2299741 tcgtttcttg gcttctctcc ttatatataa acggattcgg cgtgaaaatc tgatagccga 2299801 tgccgccgtt ctctatgaca atatattggg gagatacata atcaatcgtc cctttaacaa 2299861 attcaatcac gcaaattcac ctctttgact gttcttcatt gtaccataaa aacagccaaa 2299921 gtcttataga aaagttaaca tatgttcgct tctctctcat tctttcacga aaaaaaagac 2299981 atgaatacat gtcttcaatc agcggacgct acccgctgta tgtcttcata tgttcgatga 2300041 catcctcaaa ctccgctttt gtccgaaatg gaatgccttt cagcagattt ttttgcatat 2300101 ggctttccag cctttctaaa tcaatttgaa aaaaagactg aattggttcg gaagctggct 2300161 caggccgccc atgaaaagtg gaaatcactc cattatccga tacaccgata tacccgttga 2300221 ccttgctgag cggagaaata tcgtccattt gcttccggaa gagcacatat cccttttttt 2300281 gttccactag cgtccatccg gcataagctg cccaaaaatc atccatagaa aacacttttt 2300341 catgcttatg ctcaatgctg acatcgccgt ccaaatacac cttttcaagc tgcacatgca 2300401 cctgcagcgg ctcatagtgc tccacttccg cgccaagtgc gcgggaagga gctcctatta 2300461 aaaatactgc cgctgagcaa agaatgccca gcaaaagata cgccgtgctg aatcgtttca 2300521 ccctctacac ctctttgcac acgtttatga ttagtttgac caaagaggct actgcttaac 2300581 cgttttatca aaatttgtct gcacattttc cctgacaaac cgttcctccg tatacacatc 2300641 tgtgctttgc tcagaaattg tcaagaatcg cgtcagaaag gcactgaaaa aatacaatgc 2300701 cgcaaagatc caaatcacgc cacctgcacc gagcggccca atgaaaagac tcacgatgcc 2300761 cggcgcgata aacgcacata aaccagatcc caaattcaac actgacatgg cagcaccttt 2300821 attatcaggt gcaagcgtcg gcaaaagcgc gcttaatggg acgtaccctg ctaaagccgc 2300881 gccgtagcag caggcgataa tcatgagcac ccaatactga tgcccgatca gctgaggcgt 2300941 gtaatacagc gccagcgtaa aaataccgca tccgacaccg ccaaaccaca tgaccgtatt 2301001 gcgccagcct agtttatctc cgactgcacc gaaaatgata ttaaacacaa tattcacaaa 2301061 aaacagcgtc ccccatattt gcagccattc cgaaaccgaa tacccgtatc gtgctaaata 2301121 agtaggaaga aagatggcaa atccaaattg tcctatcgca ttaatcgtct tgaccactcc 2301181 gccgatgcct accttagggt tttcaaacat aatcgtaaat gccttcgaca gttctttcca 2301241 tttcggctga tcttgttttt gtatcggagt aaatttatct ttgttaaaaa ataaggcaag 2301301 aattccgcct gccgccacaa acagtaaagc gctccaaagc gtattgattt ctccaaaggc 2301361 cggaactgca tagctggaat agaacggacc gagcacgtta aggccgcacg taaacataaa 2301421 ccaaaaccag ccgacggctt ttccaagaat attttgagag gtgctgtatg acacccatac 2301481 gagaaaagag tatgcaaaca gcggatatcc caagcctcta agagcatagc tgcccaagag 2301541 agccggataa tacatatgag gaatcgccca gccgataaaa gcggccgaac cgaggataaa 2301601 tgcaagcaat ccgacagtca tcgtttttct cggcccccaa gtttggacaa acgttcctga 2301661 aagccaagct gagatggtga cagcaatgcc gtacatggta aataacgatg cggattgctg 2301721 catactgaga ccatgatcaa cgagaaaagg agacagccag ccttgttcga ggccgtctcc 2301781 aaccataaag atgacaacgc caatataacc ccaaaccatg tgagaaggaa ttccgatttt 2301841 gttcaaaaca tttcctttag catgtactgt attcattttc tccaccgcct acttaaagta 2301901 tcaatggagt atatacccaa gcttgctgaa ttgtaatcct gttagattaa aaagcgattt 2301961 tttcagtgtg ctcaatgcta acaggcatgc caaaagcaag cgattgctgt gctgctctgg 2302021 cgatcctccc ggcctgtaaa ccgtcattgc cggtgcaggg agtctcctgg tttgtgccga 2302081 tcgcttctgc aaaacggaga atctcctcct catatgaatc cttatagcgt tcaaggaaaa 2302141 agaaatgcgg tttatccttc atcacaaaat cagctgttga cacctcaacc gttgtcggcc 2302201 tgctattgtc agccgctgca gagcctttcg tcccgaaaac ctcaacccgc tggtcatatc 2302261 cgtacacagc ttggcggctg ttatcaatca cagccatggc accgttttca aaagtcagtg 2302321 taataacagc tgtatcaata tcacccagct ccgcaaaaga aggattcacc aaagccgccc 2302381 ctttggcata cacttccgtc acttcgcttc ccataatata tctggccata tcaaaatcat 2302441 ggatcgacat atccataaac aatccgcctg acgtacggac ataatctata ttcgggggtt 2302501 ctgggtcccg ggacgtgatt tttaataaat gaggtgtacc gatttcacca ttttcaacaa 2302561 tcgttttgat tttcttaaaa tgaggatcaa agcggcggtt aaatccgact tgaagtgtta 2302621 ccccgtgttt ccggacagcc gcaagcgctt cactcgtttc gtccagagag aaactaacgg 2302681 gcttctcaca aaatatatgc tttttcgcct cggctgcttc tttgatcatc tgtgcatgta 2302741 cggctgtagg agagcaaata aaaatagcat caatatcagg atcatgtaat aaatcacgat 2302801 aatcagaggt tatgtattca atctgatgac tgtcggccca gctttttata cggctcgcct 2302861 gaatgtcaga gattgctttt attttcatgt gaggaatccg gcttatattt tgaacatgaa 2302921 gtttgccgat gcggcctgca ccgataatcc ctgtcacaat ctgttttgtc atggcttctt 2302981 cccccttgat cattcacgaa agcgctttat ttaaaattaa tactatccca tttgtaagcg 2303041 cttttcaaga atggaaatta aacgttctat gtctctttta tcacaattca tgcttataag 2303101 tagccttctt cttcaagacc agatacacta gaattaggct ctttttcctg aacagtttat 2303161 gattttccta taaacagctg cataaaatag agcaaagaag gtgaatgaaa tgctgacaaa 2303221 agcagaggca ctggcccata ccgtcatata ccgcaagaac agcagatttg ataaagtcaa 2303281 agagaaatcc gaggaattaa cactaatcgg caagggaaga agcgcctatg tgtttgcctt 2303341 aacagaaggc ggtcgaaaaa tggcgctgaa agtatttttt ccggaatatc aagcgacagc 2303401 agtcaaagaa gcagcgatct atgaaaaatt agccgggtcc gcattctatc ctgacattta 2303461 cgaaactggc gattcattta ttctcatgga atatattaaa ggtgaaacct tttataactg 2303521 tctgaagaaa ggcattgcaa tcagtgatga catgattcag caggttgaag aagcgctttc 2303581 tgacgcccgg gcagccggac tgaacccgtc agatattcat ttgcggaatc tgatattgac 2303641 agaaaccggg gcggtgcggg tgattgatgt tgcgagattt gagcagacaa aaacatgcac 2303701 gcagtgggac gacttaaaat ccgcatatca tgcactctac aaaaaaccga tattccccaa 2303761 aaagattccg ggtttttggc tggagatcat cgcattttta tataagaaag attggtttca 2303821 aaagcatttc gcacagcgga aaagaaaata ttcttaaatc aaaaaggcag ccgcacaagc 2303881 ggctgccttt atcatgtatt ttttactttc tgacggcaga aatcagtttc atttgttcag 2303941 gcgacagctt aattcgatag cctctcacag ttaagtagac cgcttctggg tccttctcgc 2304001 cggaatgaca atacgttttt tccatttctg tctcccctca ccctttattg gctttatttc 2304061 atcttatcat tgctttattg aggtaatttt aaagaaatgt aaagattata tgaatccgat 2304121 atatagtaaa atgagagaaa aaaagggaga gagtcacatt aagaccgaaa acaccttgag 2304181 cttagatgca gccagaggtg aacttgtaaa tgaaaaaaca cttgtcaaga gaacaatcta 2304241 ctggaattac ccggacagcc gcccagcagt gacgtggatc aatcacaata cagtgaaaat 2304301 cggcaatcag actttacatc ttgatactga tgaaacgtat gattggcgaa aagatgatca 2304361 ttggatccgt gaagaaccgc cgcaggcgtc agtgaggtga tgaaacatga ataagatgaa 2304421 cggaacaaat gatgaaaagc atttcaatca ttttgtgatt gctttatcct ttatatacgg 2304481 tttgactgaa ctaggctatt tgttgctgaa ggattttata acaattgcca taagtttgcc 2304541 tctgtagaaa aacgcagcgt agtcgatacg ccgcgttttt tctttttccc ttcctcttct 2304601 tattgataat tacaggtcat ataatgtgac aaatcgattg tagaaatagt tcgattagac 2304661 caaaatcctt tttatacatg tattcgaatt tgaagtgagg gggaagcttg atggcagatt 2304721 ttgttgctag tttgaatgcg gtcttatgga gtacgcccgt catttatatt ttattgggaa 2304781 ttggattcgc cttttcaatt atgacccgtt ttttacaagt ccgacattta aaagaaatga 2304841 ttgttcagat gttcaaaggc aagagctctg aagccggcgt ttcatctttc caagcgttat 2304901 cgattgcgct gtccggccgt gtgggcacag gaaacatcgc gggagtggcg acagcaattg 2304961 cattcggcgg acccggtgca gtgttctgga tgtgggcgat tgcctttatc ggggcggcga 2305021 gtgcctttgt agaatcaacg cttgctcaaa tttacaaagt gaaacaagac ggtcaatatc 2305081 ggggcggccc tgcttattat atagaaaaag gcttaggcat taagtggttt gccgtcttat 2305141 ttgccgctgc tgcccttatt gcaatggcct ttctaatgcc gggcgtacag tccaactcca 2305201 ttgcggctgg gatccaaaat gcattcggca tctctccttt cgtcacaggg tgcggtctgg 2305261 ttttattatt agggttcatt atttttggcg gcgtcaaacg aattgccaat gcggcgcaaa 2305321 tgattgttcc atttatggcc attggatata tcctgctgtc tttgattatt attgtcatga 2305381 atgtgtctga attgcctgct gtgatctcat taatattcaa aagcgccttc gcattggatt 2305441 ccgcttttgg cggcttgatc ggtatggcga tttcctgggg cgttaaacgt ggcatttact 2305501 caaacgaagc cggccaggga acaggcccgc atccggcagc tgctgcagag gtttctcatc 2305561 cggtcaagca gggactggtt caggcatttt ctgtttatat tgacaccttg tttgtatgtt 2305621 ccgctacagc tttcatgatc ttgtttaccg gcatgtacaa tacccaggct gcagatggtt 2305681 cctttatcgt tcaccagctt aaaggcgtag aagcaggacc tggtttcaca caagcggcaa 2305741 ttgacagtgt tcttcccgga ttcggtgcag gctttgttgc catcgcttta ttcttcttcg 2305801 cttttacaac aattatggcg tattactaca tcgcagaaac aaatatcgcc tatttagcac 2305861 gaggcagaga aagcaaatgg gcgatgcttg gcttaaaact gattatttta gccgccacgt 2305921 tctatggtac tgtgaaaaca gcttcacttg cttgggcatt aggggatgca gggcttggca 2305981 ttatggtatg gctgaacgtc attgccattg tgctgcttgc caagccggcg ctccttgctt 2306041 taaaggatta tgagcgccaa aagaagcagg gcttagaccc gatctttgat ccaaaagcgc 2306101 tgggtatcaa aaacgctgat ttctgggaga aagaatacac tcatgaaagt gaacgtgtct 2306161 cctgaacata ctaaaaccgg cccgatatga cctcgtgccg gttttttatg aacgatagtt 2306221 tgtatacact tcttgaacat catcgtcatc ttcaaggacg tctattaatg tttccagctt 2306281 ctcaacagcc tgatcatcgg cttctgcata ggtattggga agcatggtca cctccgccga 2306341 agaaattaga tatttcgatt cgagggctgt tttcacctct tcaaaatgct caggctctgt 2306401 gaaaacctca tataggtctt cttcaattcg cagctcttct cctcctgctt caagcacatc 2306461 aagcatgagc tcatcttctt ctatttgccg ttcagtacgg tctatcgtaa tgaacccctt 2306521 tcgttcaaat aaaaaggcta cacatccgct ttctcccaga cttccgccat ttttattaaa 2306581 ggctgtccgc acatttgacg ccgttcggtt tttattatct gttacgcatt caaccatgac 2306641 ggcaatccct gaagggccgt agccttcata ggtgatttct tcatagctgc ttccgtcttg 2306701 gcctcccgca gcttttttaa tggcccgatc tatattttca ttcggcatat tggcgccttt 2306761 tgctttttcg atgacaagac gcaatgctga atttgcttct ggatccgctc cgccttcttt 2306821 cgctgccaca tagatttctt ttgccagctt cataaatatt ttcccgcgct ttgcatcctg 2306881 tgcatttttt cttttttgaa tgtttttcca cttggaatgg cctgccatgt tttcaccttc 2306941 ttttacattt tctatgtaca ctttaatggg aaatgttcgc tgatgcaaag aaaaaggctg 2307001 ccgaatatca cttccggcag cccttccttc ctagcggttg ttcattttat gaagttttct 2307061 gaacagccct ttatctgttg atacttggac gtcacggcca tttgcatagt tgcgcgctgc 2307121 ttttacaaca ttatctctgt cagactttgt gaactctctg tggcttttga ctgcgataac 2307181 tactcggtca tccgatacca taacttgtgt gtcattgacg tttttcactt gtttcacacg 2307241 gttggcaatt tttgcagcca gtcttctgtt ttcttggttg tcatacccgt tgttcgctgc 2307301 attccgattc atgtttcggt tattcgtgtt gttatatgtt ccgtcagttg ccaaaggaac 2307361 acgatcgtca gcagtaacac ggtcacggtt atttacattc gtggtgtttc ggttaccgtc 2307421 gttctgatcc tccattaatt cagaaacagg accatcgtgg tcgattccgt ctccctgtct 2307481 atcggcgtca ttttcatttg tataatatcc gattggacgg gtattgccgt tattgcgcgt 2307541 atcattcata gcattatcgt ttgctccgca tgctgttaag ccggctgtca ttagaatcag 2307601 gctagcgatc gtcatttttt tacccaatgg aaaaaccccc cgtggacgaa ttgagcatgt 2307661 ttgctcgctt ttatcatgtg cgtatggggg gcatgttaag cgtgtcagtt ctctccattt 2307721 ggcagtgatc tgcttgaaaa caaaaaaagg aacgatttac atcgttccga acgatcactc 2307781 attttcttct tccggacggc caaacatttg gtttacagaa ggctggttcg tcattggcat 2307841 agaaactcct gccgaatatg ggtttggatt tgggttagct gtgccatatg gcatattagg 2307901 gcttccataa gctcccattc ccgaatggcc aggtgcagag aaatatggct gatgatcacc 2307961 gtcacagccg cagtcgtcat gatctttgta tggcatgtaa ccatgagccg cagcaggctg 2308021 gtatgctccc attacttggg gagtgccgta ataagggcca tacggcatat gtccatacgg 2308081 agatccataa gccggagatg cgtattgcgg cgcaccgtat gaaccgtaat gtccgtgatg 2308141 gctgttttca tgatgctggt tttcataacc cgggtcatac tgaggcgata caaagcctgg 2308201 ctggtatcca tgcatcggat gcattggata agcttgtgcc ggatagtacg gatagcataa 2308261 tcctgatcct ggaagaattg gcgaaacagg caccggacac ggtacgaaat gagccggata 2308321 atgataataa ggctgaacag ccggcatcgg catattcgga actgtgtgat gaacgttttc 2308381 ctcttctata ccgcctacct ctggcgcctt tggcatatta ggcatattcg gataatttgc 2308441 attttccata ttactcatag cctcctgttg tggaaattgg tcttgcatat gatacatatg 2308501 atccatattt ccgtcatgat gttttttcgg ctcctccggt ttaggaggcg accaaggctg 2308561 gaaaagctgt ttcatatcat aataatcgtt cacatcagct tcagggtaca cattttcctg 2308621 caaattaggc atcggcggga catacggcat ggacttcttt tctttcggct ttgtgtcttc 2308681 tacatcgaca acggatttag gcttctcttt cgcatatgga tgttcttgct tcacactccc 2308741 ggccgcagga cttttgcccg cttttggctc ttttctgacc gggactcctt ctgacggcac 2308801 ttttattttc attccaggca tgattaagtc tggattgcta agctgtgtat tgagtttttt 2308861 cacttcctca acatcgactc cgtacttttc agctattttc cagagcgaat cgcctttttg 2308921 aacgatatgg attttcaacg ttttcccctc ctatgcaaaa cgtgaacagt tcagctgtga 2308981 ttacaatatg tttcttcaca acatatgcct gaacaaaaga agttatgagt aaaggaaggg 2309041 aaaatatttc tgatctacgt gatcgaaagc attcgattca gggcaaggag tgcatcttcc 2309101 tgaatggctt ttggcacctt gatgacgcct gaaggttctc ctttttcaat ttgttccagc 2309161 gaccacaaca aatgcggcaa atcaattcgg ttcattgtca ggcaagggca catgtcaggg 2309221 ttgagtgatt cgatttgttt atctggatgc tcgtgaatga tccgctgaac aagattcatt 2309281 tctgtcccga ttgcccactt gcttcccgcc ggagcctggt tgattgtgtc gataatatat 2309341 ttcgttgatc cgttatcatc gcttagtgtc acgacttcgt gtgaacattc cgggtgcaca 2309401 atgatctgaa tgtcggggtc tcgctctctc atatcatgga tatttttagt ggtgaatttc 2309461 tcgtgaacag agcaatgccc tttccacaaa atcactttca cattcgtatg cccggattca 2309521 gctactaatt catctttcat cggatcccac acagccatat cttcaagcgc aatgcccaga 2309581 tcataagccg tatttctccc taaatgctga tcaggcaaaa ataaaattct ttttttctgt 2309641 gtaaacgccc attcaagcac ttttttcgca ttcgaagaag ttacagttgc tccgccatgc 2309701 tttccgacga atgccttgat ctccgcagtg gagttcacat aagttaaagg tatgatcgta 2309761 tctccaaata tatgctgaag cttcttccat gccctattgg tctgctgcat gtcagccatg 2309821 tcagccatag aacatccagc tctcatatct ggcaggacga ccgtttgctg ctcgcttgtc 2309881 agcatatcgg cggtttctgc cataaagtga acgccgcaaa atacgatata atccgcttct 2309941 ttgttttttt ccgctacttg ggccaattgc agggagtcgc ctgtttggtc agcaaattgt 2310001 atcacttcat ccttttgata atgatggcct ggtataaaga gcctgctgcc gaactttttc 2310061 ttaatggcgg caacgcgcgt ttccatatcc tttctcgata gttctttata actttcgggc 2310121 atcatatcat tcgattgttt gatcacatca agaattgaca taacagcatt cctccacaga 2310181 ttcatttgat aacgtaacat ccatgctgat atctaaactt ttgacggaat gagtcagaaa 2310241 tcctaatgaa atataattca cacccgtccc tttaaaagca ggcaaagatt ctaacgtaat 2310301 cccgccagag gcttcagttt ttatattagc cggtgtgagc tttgcaaaat gacggaccgt 2310361 atcaggcgga cagttgtcaa acataataac atccgctcca gctgcaattg cttcccgcag 2310421 ctgttcctcc gtttcaattt ccacctcgat atttaccatg tgccctgcgg cctgacgggc 2310481 ttttttgcac gcctctaaaa tagagccgca tgctgcgata tgattatctt taatcatgat 2310541 gccgtcatac aaaccgaatc gatgattata cccgccgccg gctctgacag catatttctc 2310601 cagcattctg agccccggtg ttgtttttct cgtgtcacaa attttaatct gttcatcatc 2310661 cagacaccga acagcctctc ttgtcattgt cgcaattcct gacagcctct gaataagatt 2310721 taatacgacc cgctctcctg aaaggagcgc agctgcggga ccgtgtaact cggcaatcac 2310781 ttcaccttta tgcaacatgt ccccatcttt tttgtgtaaa atgctttgaa cattttcgtc 2310841 caataacgaa aagccttctt ttatgatcgc tgctcctgca aaaataccct ctgactttgc 2310901 aacaatctcc gcttcacagc tctgttctcc aaaaatagac tgcgatgtaa gatcccctgt 2310961 cccaatatcc tcaagaaaaa agtgattcag taattttttc agctgtaaat gattcattgt 2311021 tccaaatccc ctcgtttttt ctgatcttcg ttcctttttt tgtatggaca atttgtcttc 2311081 cttgccagct cacctcagca tgaggaaaat cggtgcggaa gtgagcccct ctgctttcct 2311141 cccgcaaaag cgcagaaaac gtcatcagct ttgcagtttg ccatagatga gaaagttcca 2311201 tctgccgaat tgtgatatcc ttcacattta cttcctgaaa aggcagcgta tgaagccaga 2311261 tgctaagctc aatcaaactg ctttgttccc gcagaataga catgtggctt gtcattttgc 2311321 tttgcagttc atgcccctct atatccggca cctcgtagaa gacactggtt tctagccctg 2311381 attgatattg cctgttataa accggttttt ggataatatg ctctgctgcc ctttttccaa 2311441 ataccagcgc ttccaataaa gaattgcttg caagccggtt tgctccatgt aaaccggagc 2311501 atgctgtctc gccaatcgca taaagccccg gcactgtcgt ttctccccag cgattaactg 2311561 aaacacctcc cattaagaaa tgcattcccg gagcaacagg aatttttccg ctgtggatat 2311621 caatccctgc tttttcacaa atagcggtga tggtagggaa acgcgtttca aaatcagaaa 2311681 tcgcactgaa gtctatataa acgcgatttc cttttgccat ttcttcgtga ataacccgtg 2311741 agacaatatc tcttggagcc aggtcaccta aaggatgccg ttcagccata atcctgcggc 2311801 cgttttcgtc tactaaacat ccgccttccc ctctgacagc ttctgaaaca agcccgtagg 2311861 aaacaccatt tttcacaagc agtgtcgggt gaaactgagt aaactccaaa tccgttaatt 2311921 ccgccccggc ccggtaagcc agagaaagac cgtcacctgt gacagtgaga tcattcgtat 2311981 ggtgaagaaa caggtttcca cagccgccgg cagccagcac aacttcgtct gcgtgcctta 2312041 ccttgagccg ccctttgctg tcttttgtca tgacgccgat acatcgtccg tcctctataa 2312101 gcaaatctgc tgccgtttca ttctcgatta acttgatttt gctgttgatc cgtttgagca 2312161 aataatcgat aagcagcctg cctgttgcgt ctccgcctgc atgaaatatg cggttgtatg 2312221 agtgggcccc ttctcttcca agacaaacac cgcctcgttc attgcggtcg aatggaaatc 2312281 cacgctccaa taggctttga accatcattt ttccatcatg taatacgtct gctacaatag 2312341 ctagattatt atggccgcac cctgcgtata acgtatcctc cagatgggct tcaatcgagt 2312401 catcttttgc ataggccgca gcaatcccgc cttgtgcata gacagaattg ctgtttttga 2312461 cgcttttttt tgtgataaca gtcacttcgt atgagggcgg gaaagctgca gctaaggaaa 2312521 gtgccgccgc ccctgaaccg atgactgcaa tcgtcttttt agacatatgc catcctcctg 2312581 ttgtttacac ctgtcttgac acctatattt acacaaggat aaaataaact caagagtttt 2312641 ttatggagaa cggatggagg aagaccggat gatttattta gattatgcag cgacaacgcc 2312701 tatttgtgag gaagccctta ctgtatatca gaagcttagt atggatatgt acggaaatgc 2312761 cagcagcctg catgatgcag gaggaaaagc aaagcacata ctggagtact gccgtgaaaa 2312821 aatcgccaac atcattggcg gagaagcaag cggcatctat tttacaagcg gcggcactga 2312881 atccaatttt ctggccattc aatcattgtt aaacggcctg ccaaaaacga aaagacattt 2312941 tattacgact gccatggagc atcagtccat tcataattgc gctgcttttt tggaacagca 2313001 gggatatgat gtaacagtca ttgaaccgaa tgaatacggg cttattaccg aggaaatatt 2313061 actaacccat atccggccgg aaacaggcct tgtatctatt cagcatgcaa attctgaaac 2313121 cgggatcatt cagcccattc aacacctgtc ttcatacctg cacaataagg ggattcttct 2313181 tcattgcgac gctgttcaaa cgtttggaaa gatcccgatc aatacaaaaa atctgggagt 2313241 agatgcactc tcaatgtcca gccataaaat ccacggtcct aaaggagtag gggcggtcta 2313301 tatccggccg gatgtccctt ggaaacccgt ttatcctctg actactcacg aatacggatt 2313361 cagagccggc accgtaaatg ttcccgggat cggtgccttc actgccgctg cagaattgat 2313421 cgtaagcgaa atggaaaaac agatatcccg caatgaggca ttaagaacat actttctaga 2313481 ccaaatccgt attcggtctc tccctgtaac ccttgcagca gacacttcga aagcagaatg 2313541 tcttccgcat attatagggt gtttttttca ctcatttgaa ggacaatatg ttatgttaga 2313601 atgtaatcgg agtaatattt gcatttcaac cggcagcgct tgttctgcag gttaccacgg 2313661 tccgtctgaa acaatgaaag cattaagaaa aaccgaacaa gaagctctgc aatttatccg 2313721 catctctttt ggcaggcata caacagctga acagctggaa cagttattac atacgtttac 2313781 agtgctttgg gaacaaaaga aaggagaatt tgatattgac cgaagaatta aagctaatgg 2313841 gcgccaacag gcgtgaccag cttcttctgt ggctgaagga atctaaatca ccgctgacag 2313901 gaggagaact cgcaaaaaaa gcgaacgtct caagacaggt tattgtacag gatatatcgc 2313961 tcttgaaagc gaaaaatgta ccgattatcg ccacaagcca aggatatgta tacatggatg 2314021 cagccgctca gcagcaccag caggcagaaa gaatcatagc atgtctgcac ggtcctgaac 2314081 ggacagaaga ggaactgcag ctcatcgtcg acgaaggcgt tacagtaaaa gacgtaaaaa 2314141 tcgagcatcc cgtatacgga gatttaactg cagccatcca agtaggcacc cggaaagaag 2314201 ttagccattt catcaaaaaa atcaattcta cgaatgctgc ctacttatca cagctgaccg 2314261 acggcgtgca cctgcataca ctgacagcac ctgatgaaca tcgcatcgat caagcctgcc 2314321 aagccctcga agaagccggc attttaatta aagactaaaa aaagccctct agtgggcttt 2314381 ttttataatt ggtaagactg gtatgcaccc agaagcctca ctttgcagcc gagtgcttca 2314441 agctcctgca tggcccctgg aatcaataca tcatcaaacg ctttctcaat atcaataata 2314501 aagaaataat ggcctaatcc ggttttagtc ggacgtgact caatttttga caggtttaaa 2314561 tttctccaag aaaatgcaga cagcactcta tgcagcgccc cggactgatc atcctgcggc 2314621 agcatgacca ttaaggtcgt tttgggccta gagctcaatt ttgaattcac ttcaaaagat 2314681 atgttttcat cgggagacag gataacaaat cttgtatgat tgtccctata atcctgtata 2314741 tcccgtttca cgatttttaa ttcgtatgta gaagctgcca tatcattggc aatgaccccg 2314801 atattcagct cgggatggtc actgacaaac tttgctgccg ccccggtaga attggcgtat 2314861 tcatatggaa cggaaggaaa atgtcgatga agaaatttat ggcattgcgc aatcgcgtgt 2314921 gaatgtgagt aaattttgtc gagctctttc catgcattct ctcttgaggg atggacgagc 2314981 aagtgctggt gaatcggcaa cgtcatttca cccacgattg gcaaaggctg ttcatgtatt 2315041 aaatagtcta ttgttagatt aacagatcct tctaaagcat tttccaaagg aacaaaagca 2315101 aaatcaactt cgcctgcaac ggctgcatct atacactccg gaatggtgcg gtaagcaaca 2315161 tgttcggcgc cgttttgaaa acaagaactg actgctagat gtgtaaatgt agctgctgga 2315221 cctaaataac cgactttcat gacgattttc tctcccttat gcacctgaac ctaatatttc 2315281 aaccttttct acaaaatcaa acttcctgag cttattcatt aatgtatgaa tgtcttcttc 2315341 cattgccgac gtactgatag acagtgtcac atttgctctg ccttgaagcg gaatggtctg 2315401 gtgaatggaa agaacgttgc ttccagaatc agctaccgcc tgaagaagct gagataacgc 2315461 acctgaccta tcctccaaat gaaagaaaag tgtgataatt tgttctttta ccatggtgta 2315521 gaatggaaaa acagcatccc tgtatttata aaacgcactt ctacttaaat cgaccttttg 2315581 aacggcatct gctactgaat ctgctttttt tcgatcaagc agctttttga cttctaatgt 2315641 ttttctcatt gcatcgggca atacatcttc acggacaaga taaaatgtct cctctttcat 2315701 ttgcatcccc cctttaaaat agagagcctg gcaccaggct ctcttttcag ccaacattga 2315761 ttaatcaata aattcaaatt caaattccag aagcctgatt atatctccat ccttggctcc 2315821 gcgttctctg agtgcttcat caacacccat tccgcgcatc tgtcttgcaa accgtttaac 2315881 cgattcatca cgtgagaaat cagtcatctt gaataaccgc tcaaggctgt ctcctgaaag 2315941 cacaaataca ccgtctggat cgcgtgtaat gttaaatggc acttcttcat tttccatcgt 2316001 gtacatgaca cggttttgtg taagctcttc ctcgtcatac agcgggaatt ccggtgtgtt 2316061 ctcaagctga ttggcaacct caaacagaag ctcacgcaga ccttctcttg tcaccgcact 2316121 gatcgggaat accggataat catccgtcag cttttcttta aaggcttcga gattttccgc 2316181 agcctccggc atgtccattt tatttgcaac gataatttgc ggacgctcag tgagacgcag 2316241 attgtactcg ctcagctcct ggttaatcgt aagataatca tcatatggat cacggccttc 2316301 taagcctgac atgtcaatga catgaacaat aaccctcgtc cgttcaatat ggcgcaaaaa 2316361 ctggtggccc agtccgacgc cttggtgtgc gccttcaatc agccctggca aatcagccat 2316421 gacaaagctg cgtccgtcat ccgtttcaac catgccgaga ttcgggacaa gcgttgtaaa 2316481 gtgatagtcc gcaattttcg gttttgcaga tgagacaaca gacagcaaag tagattttcc 2316541 cacactcggg aacccgacaa gtccgacatc tgcaagcact tttaattcaa gaacaatgta 2316601 gcgttctttt cccggctcgc cgttttctga aagctgaggc gcgggattag ccggtgtagc 2316661 aaagcggcta tttcctcttc cgcctcttcc gcctcttgca atgacagccc gctgtccgtg 2316721 ctctgttaaa tcagcgatga cctgttttgt atcatcgtct gtcacaacgg tgcccggcgg 2316781 aactttaatg accatatcat cagcatttcg cccgtgctgg tttttggaca tgccatgctc 2316841 gccgcgaatc gctttaaagt gttttttgta tctaaaatcc atcagggtgc ggagaccttc 2316901 atctacttca aaaacgacgt ctcctccctt tcctccgtca ccgccggcag ggccgccttt 2316961 cggcacatat ttttcacggc gaaacgcaac cataccgttg ccgccgtcgc cgccttttac 2317021 atatactttg acctgatcta caaacataat gtcctccgtt ctaaaccgtt aaaaactccg 2317081 ctagtccaac ccaatttcaa tcagacattc gtgactcgtg atttcaaaac gcatgatatc 2317141 aacgtcctca tatccattct gccgaatatc atcaaaagca gatggatcgg caaaggcgcc 2317201 gtgaaaatca aggtacagaa tcagctgtct gtcaggatga tccgtttgaa gcgaaaccgt 2317261 taaatgattt tcactctctc tgctgactgc ttgatcaaac agatgaaaca gctttctcat 2317321 cagtttcgcc agcttttgat cataagccga caaatcctta atttctccga gaacttcata 2317381 ttcaagcgtc atataatggg ttttccaatt aaacgtaaga aaatcaaacg ccaaatgcgg 2317441 tgttttcagg tttgagagct ttgattcgtg ctttgcgtct ataaccattt cttcaatcat 2317501 ttcaaagaca cggtcatact tctgtaagct taagtttcct ttaatcagct gcagcttatt 2317561 catccaatca tgccgggaat ggccaagcag atgaatcagt tcgtttgtta atgccgtgtc 2317621 gcttatattt tcttcttgat tttttgaaac atccttcatt ttcgcactcc caatcattta 2317681 atttcttatt taggagtctg tataagtgtg tattatgaat tataacagag aaggctttgt 2317741 tagaaaaaca attgtttttc ccagaaatat catgttcctt ttttctggct ttggttgatt 2317801 tgcagccagg cagaacattt tatgtattac tgcttgggga acatatccag tgggtttgag 2317861 atgtttattc tcattcttgg cggggtctgc tcgcacatac tctgcatttc attctaggtg 2317921 tttactccgc atattgcaaa aaaaactcca gtcatcatcg accggagttt tttgaatcat 2317981 tattgagcta caggatatac gctcactttt ttgcggtcac ggccgaaacg ttcgaattta 2318041 acagttccgt cgattttcgc aaatagagtg tcatctccgc cgcggcccac gttttcacct 2318101 gggtaaattt ttgttccgcg ttgacggtaa aggatagaac cgcctgttac gaattgaccg 2318161 tcagcacgtt tagcacctaa acgtttagcc tcagagtcac gtccgttctt tgtagaacct 2318221 actccttttt tagaagcgaa aaactgaaga tctaatctaa gcatgtagct cacctcctat 2318281 attatgtttg tggtcacacg caagttgtct ttgtaatccc gttcgattgt ctccagcgaa 2318341 acaatcatgc cttcaatcag cagctgagct ttttggcgtg cctctggatc aagagattca 2318401 gggaattcaa aataaaaata acccccgtcc tctcctatat caagaagcgg ctcgaagccc 2318461 gcgagcacaa tgaccgcgtt aacggcccca aacacaacgg ctgtcactcc ggcacaaaca 2318521 agatcttgtc catgttcagc aaaattcgca tggcccgtca tttcaaaaga caatatgcct 2318581 ttatcatgag accttctgat tgttgcctga atcatgctta cgcgttgatt ttttcgatcg 2318641 tcactttagt gtaaggctga cgatgacctt gttttttatg aacgtttttc tttggtttgt 2318701 atctgaaaac agtgattttt ttcgcgcggc cttgtttttc aactttagcc gttactgttg 2318761 cgccttcaac tgtagggttg ccgactttca cgttgtctcc gccaacaaac aaaacgtctt 2318821 caaaagtaac tgtttcacct gcttcagcag caagtttttc gatgtaaaca gtttggcctt 2318881 cttcaacttt gatttgttta ccgcctgttt taatgattgc gtacattctc tgcacctcct 2318941 attagactaa gactcgccag ataccagggg gctgtaaaag ctcttaacac ctgtactgag 2319001 cggttgtagc aatggtgcta catccataac attaaaaaat ataccaaaat acaaggcgtt 2319061 tgtcaatcag ttttagtagg gcagaagcag ttcctccatg gaagaattcg tccgcttatc 2319121 ggcaaagtaa gcgtgcagca cttcattctc gtcaagctgg ctgagctttt ggcctgattt 2319181 ttctataata atcggatgct tacagccacg tttgaactcg gccatcacat gatagacttt 2319241 atcctccgcc tttactgtca gcggcagaag tttctcaagc tccctgtttt ttccgtaata 2319301 cctttcgagg agaaatctca catggatata gtgcctttgc cgatattcct caaacaagga 2319361 aacagccaga aagacaaaca aaacccatgc gctgatttgc agaggaatca cgaataaaac 2319421 ccagcacccg agcagcaggc agaagcagag cgacgttttt agattaagcc ggtgagcctt 2319481 ttgaaaaggc agctgtttgg aaaacaacaa aaataacagt tttcctccat ccagcggcca 2319541 gatcggcagt aaattgacaa ataagataga aagattataa aaggtgaaga gttcaaaggt 2319601 atgctgatga atcactgaga cttctgcaag catccaggcg gcaaactgaa gccagatgtg 2319661 ctgaagaggt ccggcaataa tgaccgcaaa ctcttccttt aacggccgat tcccgtgctc 2319721 ttccacttcg accgttccgc caaacggcag caaaaaaaca cgcttgattc tccaagaaaa 2319781 aaacacagcc agagcagcat gccccagctc atgaatcaat acaatcagga gcagacataa 2319841 taatgctttc atatggcctg tgagcaagcc cagcgccgca ataatccaaa gaaaaggatg 2319901 cacatggatc tttaagataa ggtcgagcca tttattcaaa tgaaatcacc tgaatcggat 2319961 caataaattt atcgccgtct ttcatggcaa aataatagac ccctttatta tgatcatcaa 2320021 gcttaatcga accgagcttt ttgcctttat ccacaaaatc atataaagca acatccacat 2320081 ctttgagctc gccatagata ctataggtgt tgtcagcatg ctgcacctta accgtcagtc 2320141 ccgtttggct gtctttgctg acttcaacca catagccttc ttttacgcta tcaatcttat 2320201 cactgcttgt ttcgacttta attccttccc cattgtcctg aaaatcctgc tgtactttcc 2320261 cggatgcagg cgcgatcaga tctttgccta cttcaatctg ctgttcctta tttttgtgtt 2320321 caggagccag gaaagcaagc ggatttccga atttggtttc gaaccaatgg cttgctgaag 2320381 caaattgaaa ttcagtttca aaggttttgg ctacggcggg tttaatctga ctgacgggtc 2320441 caatgtttgt tttataggct atagctgaaa cgagaacaag gcaggccgac agaagacatt 2320501 tcaggataat tgaatctgtt ttcaccaatg ggtgttttcc gttgaatgtt ggcatgttat 2320561 cttcgtagac cggaagtgtt ccatgctttt cctgatccgt taccatcacc caggacgggg 2320621 gtttctgctt ttcagaaact gtctgagtag agaaacgttt tgagccggaa agctgctttc 2320681 ttcttttctc taatcgtttt ctgatttcat ctgctctgtg actcattgcc atcatccttt 2320741 gcattcgttg ggtttgtaca tcatatgtct tgtccatggc aaatattcgg tttagtcaag 2320801 aacaaagcag gcaaaaacaa aaaaaacctg acacagcata tgctttgtca gattcttctc 2320861 tttgattcta tcacattaag atcttactcc gaaaaatgac ttaatcttag ccatcattcc 2320921 tttgttttgc tcttcaagca cctgtaaagg aacagattca cctaagatgc ggcgggcaat 2320981 attgcgatat gcaatggaag cgcggttttt agggtccatc gcaatcggtt cgccatgatt 2321041 ggaagcttta atgacttcat catcatcagc cacgattccg agcaaatcga tcgacagatg 2321101 ctgtacgatt tcgtcgatat ccatcgtgtc accgtttttc atcaggtgat ttctgattct 2321161 gttaacaacg agccgcggcg gttcaatatt ttcctcttgc tccagcagtc ctataatacg 2321221 gtcagcatca cgaacagctg agatttcagg cgtagtgacc acaatcgctt tatcagctcc 2321281 ggaaacggca tttttgtacc cttgctcgat tccggcagga cagtctatga tgacatagtc 2321341 aaattcctgt ttgagctctt ggaccatgtt tttaatttgt tcaggagcaa cagctgtctt 2321401 atcgctcgtt tgagcagcgg gcattaaata gagcagatca tcgaaacgtt tgtcttttac 2321461 gagcgcctga tgcattttgc atctgccctc tacaacgtct accagatcgt aaataattct 2321521 attttcaaga cccattacaa catcaaggtt gcgcagtcct atatcagtat ctactaagca 2321581 tacgcgcttc cctaaaatgg ctaaggcggt accgaggttc gcagatgttg ttgtcttacc 2321641 tactccgcct tttcccgaag ttattacgat agcctcaccc aattcacatt cctccctcaa 2321701 gccttgttag atcaggtctt aaatgagcca aatgttgaag gcgttcaatg accatatttc 2321761 cgtctgtatc taaataagca cattccattt cgttcccttt ttgaatgtgg tctggggagc 2321821 gatttaacac atgattgatt cttaattgtg tcggaagcat ttcagaggcg gcgatgaccg 2321881 cttgattatt tccattgaat ccagcatgcg caattccttt cagtgagccc agaacaaaaa 2321941 tgttccctcc ggccctgact gttccgccgg gattcacgtc accgatcagg agcaagtcgc 2322001 cttttacctg cagcacttgg cctgaacgga caatttttga aacagaaata atttcggctt 2322061 cctctcttat ctgctgtgct tcttttttag taatgacttc actgtcaata gaatgaacaa 2322121 acaaatcttt ctttgacgca atcaattcgg ttagctgttc ctcttgctcc ttatataaaa 2322181 agcgatttcc cagcttaaca tgaacgctga ttttctggcc ttttccatcg gtatattgtt 2322241 caattgacag catattctga agaccatcga gaagctcatc aaaagaacac gcatcatcca 2322301 gatgcaatgt tagtccattc tttgttcctt ttattgttac atattgctgc tttttggtct 2322361 tcacaatatt cacctcaaca acatactcat ttcgtcaaaa aaagataaaa tcctttttac 2322421 tcatctctca attctttctt tagactcata aaaaacaatc taaatggcag aacaagaata 2322481 agagctgctg caatatttaa taaaattgtc ggtataaacc ggtcaagcac aaatccgtta 2322541 aacgtcataa tgtctttatg aatcaaagac tgaatgccga atacgtaaaa ttcgagcaga 2322601 cagacagcca gaactgctat caatatcact acaaatgcgt ttgtatgcaa cactttaaac 2322661 gcttttgaag ccaaatagca tagccctgca aaaccaaaca tgtaaacgcc taatagactt 2322721 gtatagttca tgtcatatag aaagccaaaa ataaatccgt aaatcatcgc gtgtttttgg 2322781 ttgataaaag ccgacatgaa tatcaataca agcatcaaaa aacgcggggc gagcacttgg 2322841 tcatctgtaa cgaaaggaaa atgcaccaaa tctgtaaaaa tgctttccgc agaaaaaaca 2322901 agcatcataa cgaaagggag aaggaaacgt ttcacgatcc ttcctcctct gtatcgacag 2322961 tcggcacgtc acggttaaca acgatcacat tatttaaatc tgtaaggtca gccgcaggtt 2323021 ttacataagc aaccttcgtt aatccatagg aatctgactc gatatcagtc acttcaccga 2323081 ttgtcagccc ttctgggaaa acaccgcctg tccctgatgt ttcaataaga tcgccttttt 2323141 tcacgtcttg tttatcctta cgctcaataa ttgtcatctt aagacgtttt ttctctttgt 2323201 catatccttc gatcaagccg tagcctttgc tgcctttttt tccggaaatt tttgtcgcga 2323261 ctctgttatt gcggtcagta tcgcttaaaa gctgaacagc agacgtaaaa ttgttaagtc 2323321 cggagctttt gatcttgccg attaatgcgc ctttttcgtt tgtaacggcc atatctttcg 2323381 ctacgttttg ctgagtcccc ttgttaatgg tgacctgttt cgcccaatta tcagggcttc 2323441 tggcgatgac cgttgctaaa atcggcttgt aatctttaat cgatttgaca tggccaagct 2323501 cgtcacgcaa ggatttgttt tcttcttcaa gctcttgaag cttggcttca tattgtgtct 2323561 gtccgtcaag tttttctctt agacgctcgt tttctttgta tgtgtttttt aaatcattga 2323621 tgttctcaaa tattcctgca aaaaattcgg caggcgtatg aaaaatattt tgaaatactc 2323681 ccgtcgtatc gccgatcact ttctcaggcc aggtggtatt gcggccgccc ttcagcgaaa 2323741 atccaatcat agccaccaat atgataatac acagaagtaa tagcattaac cgcttattcg 2323801 gcatcgtgtt acacctcttc tattgaactc ccgattatct agttttccct ttgaaaagat 2323861 ggatgtgctc cagtgctttc cctgttccga tcgctacaca atcaagcgga tcttcggcga 2323921 taaggaccgg catttttgtt tcttcgctga tgactttgtc caaattgcgc aaaagcgctc 2323981 cgccgccggt taacactata cctctgtcca tgatatctgc tgcaagctca ggcggtgttt 2324041 tttcgagtgt gctcttcact gcttcgacaa ttgtagatac agtgtcgcgt agagcgttag 2324101 aaatctcttt tcctgtaatt tcaattgttt tcggcaaacc tgtgagcaaa tcgcggccgc 2324161 ggatttccat gttgtcggat tcttcaggag cttctgcaga tccgatttcc attttaatcg 2324221 cttcagccgt acggtcaccg atcatcagat tgtacgtttt tctgatgtag ttgataatcg 2324281 cgtcatccat ctcatcaccg gctacacgga ttgactgaga cgttacgatg cctccgaggg 2324341 aaataatcgc aacttctgtc gtaccgcccc cgatatcaac aaccatgctt ccagtcggtt 2324401 cccaaactgg cagattggct ccgattgctg cggcaaaagg ctcttcaatc ggatacgcgt 2324461 cacgcgctcc cgcctgtctt gtcgcatcga taacagcgcg ttcttcaaca gctgtaatgc 2324521 ctgatgggac acataccatt acatatggtt ttctggcaaa catgccttta ttttttatgg 2324581 cctgattgat gtaatatttc atcatcgtcg ccgttgtttc ataatcagcg ataacgccgt 2324641 ctttcatcgg gcgaagagcc accacgttgc ccggtgtccg tccaatcata tttttcgcat 2324701 catttccgac agcgacaatc gatttcgtat ccgtctgcaa agcgacaact gacggctctc 2324761 tcacaacaat tccttttcct tttacaaaaa caagcgtatt cgcagttcca agatctatac 2324821 caaggtctct agcaccaatt ccaaacatat gtatgtatct tcctttctta aagcaaaaat 2324881 accctaaagg gaaaaactca taaactctat tatagcttaa ttcgacgaaa aaaaaagtgt 2324941 tacaaatatc ctttttcctt taaactcaca aattttttat ccccgatcac caaatggtca 2325001 agcagctcga tgccaatcag gtttccgcat tcaaacagcc gtcttgtcac ttcaatatct 2325061 tccctgctcg gcgtcggatc tccagaagga tgattatgaa cacagataaa ggaagcggca 2325121 gatcgtttaa acgcttcttt aaacacctct cgcgggtgga caatagatga attcaggctt 2325181 ccgataaata cggtgcgttt atggatgact tgattttttg tatttaagta taaacagaca 2325241 aaatgctcct gggttaaaaa gcgcatatcc tccatgacaa gattagcgcc gtcttccggg 2325301 gagcgaataa cgaaatgttc ttcgttggct aatttatgaa tccggcttcc aagctcaact 2325361 gctgccagta tttgaatcgc ttttaccata ccgattcccg ggatgcttga cagctcttca 2325421 accgatgctt ccttgagcag gcgcagcccg tcaaatgagc gcagcagccg gtttgacagg 2325481 tccaaaacag attcgtgttt agtccctgtc cgcaataata tagccaaaag ttcatgattc 2325541 gctaagttct cggctccgac tttcaggagc cgttcccttg gcttttcttt cattgggaaa 2325601 tctttgagtt ttaatggcag atcgtgtatg accaagcact ccttttcttt cccttcccgt 2325661 ttatagaacc gtcatgccct tatatcaaaa tggcgaagag ctctcattgt ttttgatata 2325721 ggaaggccca tgactgaata ataatctccg tctattttct ttacaaaaag cgcgcctctt 2325781 ccttggatgc cgtatgcacc tgctttatcc atcggctctt ttgtttcaat atatgtccaa 2325841 atctcttctt cactgaggga ccaaaacgca acttctgtct tatcataaaa agtctcgctg 2325901 tgattttcag cttgaatgct gaccgcggtt attactgagt gacttcggcc tgaaagcctc 2325961 cgcagcatag aagcagcttc ttcttgatcc tgcggtttgc caagacattc gccgtcaagg 2326021 cataccattg tatcagcacc gataacgatt gcatgcgggt ggagatcagc tacagcctta 2326081 gctttttgtt ttgccaacca ttggacgttt tcttctggtg aaaagtttcg atttaatttt 2326141 tcttctactt cactgacaat aatggagtag ggcagctgga gaagatcgag gagttctttc 2326201 ctgcgcggag attgtgatgc aagtattagc ggttttgtca tgttcgtcat cctttcaggg 2326261 tttgcttaag aaaaaaagat actcgtttat cctaccaaat cacgaggctt gtcacaattt 2326321 cagaaaaata actttttcat gacaaaataa aaaaagcctg tcactaaagg acgaaggctc 2326381 agggcactat ctcttatttt acgacggcta acagctcctg ctgagccttc cacccggctt 2326441 cagcacttgg atcctctaat tcctttaaag cctgcaaaat cgcttttttc tctcctgttt 2326501 ctgacgcttt tgtttcacca agcgactttt ctattttctc tacactcgct tttgtaatgt 2326561 cttcgtcgag aatcgccttt gctgcaagct ccgctgtttc cttaaaagaa tctgtcatat 2326621 ctgactctat tgataaggaa agctccttgc ctccccaggc ttcaaaatca ctgtcgatta 2326681 aaacctgtcc taactgctgt gagacctcct tttcacttgc taagcctgca ataacatacg 2326741 tatacccgtc atcctttgac agtgacacgg cggaatatcc tttttcggtc aattgttctg 2326801 ttaacgtttc ggcgcccttt tcatttgaaa attttccggc ttgcacagcg tatgttttgt 2326861 atgtaccttc agtttgtgcc gcttgttttt ctgcgcctga ggtttgttta tcagcagaag 2326921 tatcccctgc ttttgccgtt tggctgccta aagaatcctc taaagaggcc ggtgctgacg 2326981 cttctttatt ccccgatatg tttaacgcga ataaccctaa tccagtgcca atgacagccg 2327041 cgaaggcaat cgtcgcggcc actcttttta ccggtttggc agccccggtc tttccttttg 2327101 cgtaaagctt tgtttttttc ttttgaaaag gaggaacaac tttagggtcc tctttaaaca 2327161 ccttgtcctc ctcggaatcc caattgaatt catcttcatc agggtgttcc tgggatgccg 2327221 caacctcttg ttctgcctgt cttttttcct cccaatttga aaatgtcatg cttttattcg 2327281 cctctgtctc aggcgtctct tgttcgtaaa ccgtctcttc ttttccatta atcgtcacct 2327341 tgagggcttt ttctgcggct ttactgtttt ttttattctt tctttttttc aattccgctt 2327401 cctcccttca tttgcttgac cgttcttgtc ggcttttcat gctacacact ttagcacagg 2327461 caaagaaaaa aagaacaaga cttttgtcgc cttgtccaaa aaacgttcgt caaatttttc 2327521 agcagtcagc ccaatgccat tttgatataa aaagaaatga tagagtcacc gtataaatag 2327581 gctaaaatgc tccctgcggc tatagcgggg gcgaagggaa gcggctgcct tttagcgagt 2327641 ctaccagtca gaacagctgc cgctccatat aatgcaccta tcaaaactga aaagaaaaag 2327701 gcagctgcca gcattttcac accaagcaca aagccaatca ccgcaaataa tttaatatct 2327761 cctcccccta ctcccccatg ggtgattgcg gcaattacag ccagaaacaa aaatccggct 2327821 gccgcaccta acaggcctgc ataccaggaa tcaagcggag aaatcaatct cgcggccgcc 2327881 aaaaagggaa gaaagaaaat caatattcga tttggaatca gcataaaatg aatatctgtc 2327941 actgcaacaa taatgagaag agagataaac accacagcgg gaaacagttc cagcgatatg 2328001 ccaaagcgta ttcctgcggc ggcaaataaa cacgctgtca caagctctgc tgcgggatac 2328061 ataaaagaaa tcctatgccc gcagctttta catttacctt tttgaaatag gaatgacagg 2328121 atgggaatta attctgcagg agttaatgtt cgccggcaaa acgggcatga tgaacggggc 2328181 gcaataatag atagatgtaa ggggatacgg cacccggccg tatagtaaaa agaaccaagg 2328241 ataagcccga agataaaaag aatggatagc atagacaaca cacctttact cattgagttc 2328301 tggtatggat tgtagcaaaa tggacatcct gagctccaat tgggaatatt caattttaca 2328361 catgaaaaaa acggcagaat ctttttttga ttctgccgga gccggatgct tttatttcaa 2328421 cctttttcga atgtcagaaa taaagtaaag agatccggta atcagcacaa tttcatttga 2328481 gcccttttta ctttctatga atttgattac atcgtctgga tcttcactcc agcttttatt 2328541 gctgatttca cttgcatcat agagatcttt tgcaagggaa gcacgcggga aatcaaaaga 2328601 agcaaaatga atcgcatgag caatggtttc cagtctttta atcatgttct gatacggttt 2328661 gtcctttaac gcgctaaaca ccacagaaat gcgtgaattg gcgaaacgct gcttcatcgt 2328721 ttccgccagc ttttcaacac cttcttcgtt atgcgcaccg tctaaatata ccggaggatg 2328781 ttcctgaaca agctctaacc gtcccggcca agcagccttc acaagcccgc tccttaacgc 2328841 ttcgtcactg atatgggcga tattctcctt attgagccac tccgcagcca aaatggacaa 2328901 agcagcattt tgtctttgat gggtgccaat cagagatgtc cgaatatctt catagcattt 2328961 ctcttccgtt ttgaatgaaa actgttctcc tgcaggcaga gcctcttcat tgaaaataac 2329021 acatgcatca tgcaatgact ggaacggcgc agcatgccgt tcggcttcat ggcggatgac 2329081 ctgtaaagct tccggctggg taactgctgt aacgattgga ataccttctt taataatgcc 2329141 ggccttttct cctgcaattt cttcaatggt gtttcccaaa atgttcatat gatcgtgtcc 2329201 gatgcttgta atcacagtta agagcggttc aaccacatta gtagaatcga atctaccgcc 2329261 cagacctgtt tcaaaaataa caaaatcgac cttatgaaac tctgcaaaat ataaaaatgc 2329321 acaagctgtc ataatttcaa attctgtcgg ctgtccgtat tccgtttgat caagggcttc 2329381 aacgtgcggt ttcatttgat tgacgagtgc tgtccattcc tcatctgaaa tcggtatccc 2329441 gtttacgctg atccgttcat taaacgtaat aatataaggc gatgtaaatg ttccaaccgt 2329501 atatccggct tcctgcagca tagaacggat aaaagcgaca gttgatcctt taccgtttgt 2329561 tcctgcgacg tggaacgctc ggattttttt ttcaggatgt cctaaccgcg ccatcagctg 2329621 tttcattcga ccaagtccgg gcttcacccc gaatttcagc ctcccgtgaa tccagctgcg 2329681 cgcatcttga tatgcagtaa acaatgataa tcccctcttt tataagacaa ggcggtttct 2329741 ctagaaaccg ccccggcttt tcattaaccc ttcagctcag ccattcgttt ttgaacagcg 2329801 tcacgcttcg ccacataatc tttttctttt tcacgttctt catcaattac gtgtgcaggc 2329861 gcttttttca taaatccttc atttccaagt ttcttttgga cacgctcaac ttcttttgtc 2329921 agtttatcaa attctttttg cagacgggca atttcttcat caatattgat taagccttca 2329981 agcggaagaa taacctctgc tcctgagaca acggccgtca tcgccttatc aacagcctca 2330041 atatcggtgc cgattttaag cacgctcgga ttcgtaaagc gttcaacata tgaacggttc 2330101 gcttcgaggc gggacgctat ttcgtctgtg cttgttttaa tgtacagttc aacctgcttg 2330161 ctcattggcg tattgacttc actgcggata ttgcgcacag aacggatcag ctcaacaaga 2330221 agcttcatgt cagctgccgc ttcagtatcg gtatgctccg gcactactgc aggccattga 2330281 cttactgtaa tcgattcccc ttggtgagga aggtgctgcc aaatttcctc cgttaagaat 2330341 ggcataaacg gatggagcag acgcatcgtt tgatcaagta cgtaagcaag gatggaacgg 2330401 gtagttttct tagccgcttc gtcttctcca taaagcggaa gcttcgccat ttcaatatac 2330461 caatcacaga aatcatccca aataaagtta tataaatggc gtcctacttc accaaattca 2330521 tatcggtcag caagctgggt cacgtgctcg atcgtttcat ttaatcgcgt taaaatccac 2330581 ttgtcagcga ctgacttttc acctgacaga tcaagctcat cgtacgtcat gccatccata 2330641 ttcattaatg caaaacggga ggcgttccaa attttattgg caaaattcca ggtcgattcc 2330701 actttttcat agctgaagcg cagatcctgg ccaggagagc ttccagtcgc aaggaaataa 2330761 cgcagagaat cggctccgta cttgtcaatc acatccatcg ggtcgacacc gttgccaaga 2330821 gatttactca ttttccggcc ttgctcgtca cggattaagc cgtggattaa aacatctttg 2330881 aacgggcgct cgcctgtaaa ttcaatgcct tggaaaatca tgcgtgatac ccagaagaaa 2330941 atgatatcgt accctgtcac gagaacatct gtcggatagt agcgtttaaa gtcttcagcc 2331001 gttacatcag gccagcccat tgtggagaaa ggccatagcg cagaactgaa ccatgtatcc 2331061 agtacgtctg tatcctgttc ccaattttcg ctgtcttccg gcgcttcaag tccgacatat 2331121 agctcgcctg tttctttatg ataccaggca ggaatacgat ggccccacca caattgacgg 2331181 gagatacacc agtcgcggat attttccatc cagtgtaaat acgttttttc gaaacggtca 2331241 ggcacaaagt tgaccttttc ttcttttttt tgcagctcaa tcgctgcatc agcaagcggc 2331301 tgcatgcgca caaaccattg tgtagaaaga taaggctcca caacagcccc gcttcgttca 2331361 ctatggccga cagagtgcat atgatcctcg atcttgaaga gaactcccgc ctcctgtaaa 2331421 tctttcacga gctttttgcg gcattcaaaa cgatccatac cttgatattg gagcgcattt 2331481 tcattcatcg tgccatcttc attcatgaca aggatgcgtt ctaaattgtg gcggttgcca 2331541 agctcgaagt cgttcggatc atgagcaggc gtaattttca cggcacctga accaaattcc 2331601 atatcaacat agtcatcacc gacaatcgga atttcacgat ttacaatcgg caggatcacc 2331661 gtttttccga taaggtgttt atagcgctcg tcttcagggt gaacggcaac agctgtatca 2331721 ccgagcattg tttcaggacg tgtcgtcgca atttcaattg agcctgaacc gtcagcaagc 2331781 ggatagctca tatgatagaa tgcgccttga acatccttgt aaatcacctc aatgtcggat 2331841 agggctgttt ttgtcgctgg gtcccagtta ataatatatt cgcctctgta gatcaggcct 2331901 ttttcataaa gcttaacgaa tacttccctt accgctttgc tcaagccttc atccagcgta 2331961 aaacgttcac gggaataatc taggccaaga cctaatttcg cccactggct gcgaataaag 2332021 tcagcatatt cttccttcca cttccacgtt tcttcgagga atttttcacg gcctaaatcg 2332081 tagcgggatt tgccttcttc acgaagtttc gcctccactt tagcctgtgt cgcgatgccg 2332141 gcgtggtcca tgccaggaag ccacagcaca tcatagccct gcatgcgttt cattcttgtt 2332201 acaatgtctt gcagcgttgt gtcccatgcg tggccaaggt gaagtctccc tgttacgttt 2332261 ggcggcggga tgacaacaga gtatggctct tttgtctggt cactgcccgc ttcaaaaaat 2332321 ttgcctttta gccaaaaatc atatcggtct ttttcaaccg ctgccggatc atatttcgtc 2332381 ggcattgttt gttcattcgt ttccatcata accctccagc atgtttaaaa atggctgaga 2332441 acgaaaaaag agctcttcat ccctgtaaaa ggacgaaaag ctctttcgcg gtaccacctt 2332501 ttttcatgaa ctcaatcagt tcatgcactt ataacggata acgggtgttt cccgaatttc 2332561 tctactcttc tttcaagaaa ttatgctccc gggcgacctt ccaatcagac aacataagaa 2332621 gcctttcagc aaacggcttc tctctctgca tgcgcctttt ttgtactctt cccgttctaa 2332681 gcaggtgtat ttatcagctc attgtataca ttatttatgt tctttattat agtaaaagtg 2332741 tttttgattc gtcaatcatc ttttccaaaa acaccgcttt ctatacagat gggcaggcac 2332801 ctattgccca agtttacata tgatgcttgt aaatgcgtag aggaggatgc accgtgaaga 2332861 aacgtttcag ctcttattcg ctgccgccat gggtaaggca aattcggctt gtatccgcac 2332921 aagtgattat tcccattacg atttttcaag gaatcagaac cattttcttt ccgacaacct 2332981 ttgatgtttt gctgctcgca atcctaatct ttttagcttg cgcccttcat ttagaatgga 2333041 tataaacaaa caagtccgcg ccattaagac gtggactcgt tttcagcctg aaattttttc 2333101 tcttgttcaa tctgatgaat tttcatcaca aacggctcta tgtttttcat ttgccaataa 2333161 gcctttaata attgtgtaca ttcctctttt tcatgctgtc ttttcccagt ttgataaccg 2333221 ttcagcacct tgtacatggc tgccggatat gccatatagc tgagaaaaag gctgacttcc 2333281 gcttcacgca aagggaatga tttcgtatat ccataaaacc attcgacgca ttccggacaa 2333341 gctttcggaa agcctctgaa catttttgta taaaagccga gcaggtcgtt ttgcggcgga 2333401 ccgacagatg ctctttcgaa gtttgtaaaa tatccggtcc cggcatcatt atacagaaaa 2333461 tggtgtatag acaggctgcc gtggttcatt acaacccttg aaacgtcctt ttcctttgcg 2333521 gactcatacc agtcctccag ccgttccagc gcaaagttca ccgcggaaat ggtttcagaa 2333581 aaataggtta tggcctggag ttcaaaggga gaaaggtacc attccttctc cgctctatcc 2333641 acaaactgct catagaaaat tttatcttgt tcccactttt ttttcgtttg cccgtaataa 2333701 cgttcaatct catcacgtct aacctttagt tcctgcgcgg ttctctcgtg aagacgggct 2333761 gtttctctaa ataaataagc atgtttttga tcccgttctt cctcttggtc aaattggagc 2333821 caaggcatta aatagtagat atctccgtat tgtatgcctg ctgagaaaaa ctcaccgcta 2333881 tttgttctgt aaacgggaac gaatgaacga aagccttttt cctcaatcgc caccatatga 2333941 tctgtaaaat gcttgccgcg accttctttc aattttttca gggcaaatat gccgtagtct 2334001 gtatacactt tccaaacaag aggactgaca ggctcaataa attgagcagt cagtccgtat 2334061 tcctgaagaa ccgattgggt atcttccatt tcattcacca cattttccga tcacttacgg 2334121 tttacgcatg gctattttta tattgaggaa tatagagaat ctgtcctgct tttaattcat 2334181 catccaaggc taaagaattc atcctgatca gctgctggga tgtaatttca taccgttcgc 2334241 ataaacgctc gatcgtatct tcctgctgca caatacaaat tttcattctc gaaaactcat 2334301 ccgcttcttt tgtaaagagt tttgttaaat aaagagaatt atcactttcc tttgtttgag 2334361 gttccttcgt ttcagcagca ggagcaaccc taggaacagc atccgtttcc ttcctttcag 2334421 tctcagaaga ttcaggcagc tggaaggatt gaaaaggtgt ttcttcctta ggctcttcag 2334481 ctgatggtgt ttttctcact tcaatttcga agctctcttc ctcttgttct tcctcctcca 2334541 gcagcttagg cgctgaataa aaagaatcct cctcttcttg ttcaggcagg aaggtacggt 2334601 atgccggttc aggcaattct tcttgagatg cctcctccga gcttgttttt tgattgaaat 2334661 ggaaatgtaa atcggcattg tcattctcca tatatacagc tgaagctgtt tctctgctat 2334721 cttctatgga gagagcggcc tctgatacac tctccaaagc ttcatccggt tccgcctctt 2334781 cttggcaaag cgcaggatca gcctgatccg attgagctgc ttcttcattt tgagcctctt 2334841 ggcgcagcgc atattcatga ttaggagaca ctgttgtttc ctctttttcc tttgcaatca 2334901 cagtctctga atgaagctca gcttccaaag caggcgattc ttctgctcca acgtgttcac 2334961 gaagctcagt ctccgctgga gagtctgctt cttcacgaac atccgctatt gcagctgccg 2335021 gctctgccgt ttcttttttt gctttaacga tctcttgaat ctctatttct gaaggatcag 2335081 gttctggctc agattcttct gtttccgatt cagcacgaac ctccgtttcc ggcacagcaa 2335141 gctcttctga ctcttcttcc tctttcacat cttctctggc ctctggttct gaagcaaccg 2335201 attcaggcgg ctcagattct gctttttctg tctccagttc ttcacggagc cccgctttcg 2335261 agataaaaag ttctggcggt tcggctggcg gttcatgctg aagaactgct tcctctgccg 2335321 atgatgcacc cggttcttct actacactat gtgccggcgg ctctgaaagc tcttcctccc 2335381 tgaatgccgc aggagcttca tataaaggta tctccggctc tttgtcttgc gtatcgtcca 2335441 aaagcccttc gatcgctaaa tcagcttgaa ttgttaaaat gcgcgaatcc gtcaattgat 2335501 agtcaaatgc gtcaataaag acgaagacat cctgtaaatg gctcacttta tttttcggaa 2335561 tggtaatatc cacaggaaaa cagtgagtca gttccgcact tccatcctct ctctttctga 2335621 cttgttcaac aaaccgctta tctgtataaa tctcttcggt atgtttgttt tgatctatgt 2335681 tgtactcacc tgtaagttca agcgatccta tgattgatac ataatcattt acttcctgaa 2335741 ccctaatatc aggatctaat gaaatagaaa gcagttcaga aacttcctgt cctttttgga 2335801 aacagatcga ttcttctaca gaaaattgca atcgatgatt ttgcggcaag ttcatatcct 2335861 cctttcatct aatccttaaa attagatgtc actaaaggtg tatgtatgaa ctggagaaaa 2335921 tatgagtggg agagcacgaa aaaaccggca caaggagtcc ttgataccgg ttttcactct 2335981 tatctgcggc tgatctcagc aaatactttc tcagctgcct ggattgtgtt ttcaatatct 2336041 tcatcagtat gggccgttga gaggaaaaga ccttcgaatt gtgatggcgg aaggaatacc 2336101 ccttcatttg ccatcccttt ataatagctt gcgaacagct tcaaatcaga tgatttcgct 2336161 gtttcataat tgatgactgg ttcgtttgta aagaagaaac cgatcatcga acctgcacgg 2336221 ttaaaggtat gcggaatgcc atgagccccg gcggtttttg aaattccttc ttccagtctg 2336281 tcgccttttt tgatgaaatt cttgtaggat tcaggtgtca gctgtttcaa tgtctctaag 2336341 ccagccgtca tcgcaagcgg gttgcctgac aatgtaccag cttgatagat cggaccgctt 2336401 ggagcgatct gctccatgat ttctgccttt ccgccataag cgccgacagg aagtccgccc 2336461 ccgattactt ttcctaaaca agtcagatca ggcgttacgc cgaagtagcc ttgagcgcag 2336521 ttataatcga cccggaagcc agtcatcact tcatcaaaaa tcagcaggga gccgtactgc 2336581 tcagtgatat cacgcagacc ctgaaggaaa ccttcttgcg gcggaacaac acccatattt 2336641 ccggcaactg gctctacaat gactcccgca atgtcttcac cgaattgctg gaaagcaagc 2336701 tttacacttt ctaaatcatt gtacggaacg gtgatggtgt ttttcgcaat gccttcaggc 2336761 acccccgggc tgtcaggcag accgagagtg gcaacacctg aaccagcttt aatcaagaga 2336821 gaatcgccgt gtccgtggta gcagccctca aattttaaaa tcttgttgcg gcccgtatag 2336881 ccccttgcca aacggagggc actcattgta gcctctgttc cggagcttac cattcgtaca 2336941 atttctacag atggcacacg atcaatgacg agcttagcca gttcattttc tacttcagtc 2337001 ggagcaccaa agcttgtccc gtattcagcc acttttttga ggctttctac gacgcggtca 2337061 tttgtatgcc ctaaaattaa aggcccccat gacaagacgt agtcaatata ttcattcccg 2337121 tcaatatcaa agattttcga gccttttccg cgctccataa aaatcgggtc catgtctacc 2337181 gatttaaatg cgcgaacggg actgttcaca ccgcccggca tgagtttttg cgcttcttta 2337241 aaagccgttt ttgatttttc atagcttctc atctgcctca actcctgtca actgaataaa 2337301 attactccgc aagccatttc gctgcgtctt tcgcatgata cgtaataatc aggtcggcac 2337361 ccgcgcgctt catgcttgtc aaaatttcca acacaatttc tttttctttg atccagccgt 2337421 tctgcgctgc agccttcacc attgaatact ctccgcttac attataagcg acgagcggca 2337481 aagtaaactc attttttacg tcacgcatga tatccatata agaaagcgaa ggtttgacaa 2337541 tcaaaaagtc cgcgccttcc tcaacatctg attgtgcttc gcggagtgcc tccatacggt 2337601 tggcagggtc catctgatat gttttgcggt ctccgaattg cggtgtgctg tttgctgcat 2337661 cacggaacgg accgtaaaac tcacttgaat atttaacagc gtaagacatg atgggaatat 2337721 tgacgaatcc ttctttatca agtgcttctc tgatcactgt aacaaatccg tccatcatgt 2337781 ttgatggcgc aatgatatcc gcacctgctt tcgcttggct gacagctgtc tgcgccaaaa 2337841 gctccagcga ttcatcattg agaatgactc cgtctttgac aagtccgcaa tggccgtggt 2337901 ctgtatattc gcacaggcac gtgtcagcga caacaaccat ttcagggaag tgttctttaa 2337961 tttctgtgat ggctttttgg acaattccgt gatcatggta cgcttgtgtt ccgcaatcat 2338021 ctttttcttc cgggatgccg aacacgataa cagattgaat gcccagtttg accagctccg 2338081 ctacttcatc cttcaataaa tctaatgata catggtgaac atcaggcatt gacggaacag 2338141 cttttttgcc ttccagccct tcaacgacaa aaatcggata tataaaatct gatggatgca 2338201 aacgtgtttc ctttaccatt tctctcattg cttttgatgt ccgcaggcgg cggtgtctat 2338261 taaatgattg actcatattc tctcttcctc tcttgacatg ctgcacatta actcaagcat 2338321 gccatctatt gtaaatgtat caggcgtatg cgatgtgatg ccgtacgtca gaagggcatc 2338381 atttgttaaa ggcccaatgc tgatacaggc cgtcccattc gccttccact tttttaattc 2338441 ttctcccaag acatgcataa acgtatgtac ggttgatgaa ctcgtaaatg ttacatagtc 2338501 aaaggaatat tgacccgcag cgtctttcaa tgcctcaatg ccttcttcat ccggaatcgt 2338561 ttcgtagaga acccattcct ttacttcaaa accgagcggg acaagctctt gttttatcac 2338621 atcacgtgac aaattccctt tcatcacggt aatggtctcc cccggttcag catgctgctt 2338681 aagagcgtca gccaattgtt cagcaatata ctcctgtggc atcacatcaa ccgatacgtt 2338741 atgcattttt aaacggcgcg cggttttttc accgacggct gcaatttttt tatgcgcagg 2338801 gagaataagc tgattttcct tcagataaga aaaaaagaag tctgccccgt tcacacttgt 2338861 aaaaacaagc cagcctggcg cggcaagatc ctctcttacc tgttccgcaa catcattcgg 2338921 caaagcgcgg cgaaacgtaa tcaaagaggt taaaaccgct ttaccgccaa gcgcctccac 2338981 tttttgctga aatgatgctg cctgtgcctt attccgggtg acaagcactg tttttccttt 2339041 caacggaaaa tcattttcca tcctcgtcaa gctcccgttt tacacgatca attaaatctt 2339101 ttgctccttt gtcagccata agagcggcac agcgctttcc tacttcctcc ggatcgtttc 2339161 cggtgacggt ttctttaaaa atgattttgc cgtcaggtga agcgacaaga cctgtcattt 2339221 caatttcatc ctgtccattt aacacggagt agcccgcgat cggaacctgg cagccgccct 2339281 ccatcgcgtt taaaaaagca cgttccgcta agacagtccg ttttgtatat tcatctgtaa 2339341 actgagaaaa caacgccaac agctcttcat ccgattctcg gcactcaatc gccagggctc 2339401 cctgccccac agcaggcaaa cagcgctcag gctcaaggaa ttcggttacg acatcttgct 2339461 tccaacccat tctggaaagg ccggcagccg ctaaaataat tgcgtcataa tcctctgttt 2339521 ccagcttttg aagtcttgta tctatattac ctctaatcca tttaattgta aggtcagggc 2339581 gctcaatcaa aagctgcgcg cttcttctta aactgcttgt gccaatgaca gcacctttct 2339641 tcatttctga aagctttacg cgattctttg aaataagggc atcacgcggg tcctcccgtt 2339701 caggaataca gccgatcaca aggccttcag gcaaaacagc aggcatgtcc ttcatgctgt 2339761 gcactgccat atcaatctct tcgtttaaaa gcgcctgttc aatttctttg acaaaaagcc 2339821 cttttccacc cacttttgag agtgtaacat cgacaatccg gtcgcccttt gtcacgatct 2339881 ctttaatttc aaaagcaaac gaaggattga tttccttcag tttttgaata acccattttg 2339941 tttgagtcat agcgagtttg ctccgtctgg aacctacttt aatcgttctc atcatttctt 2340001 tcctcccgaa tctgcttggg acatcgttta actgaaccaa tggaattgcg acaggcttcc 2340061 aagcaggaaa taattgatca tcagcaccag aaaacaagcc gtattccaca gtgcagcgac 2340121 ctttccttgc agctccttaa tcagcctgat ataaagataa tagctgtaca gcagcaggac 2340181 gacaaacgaa ccaagcactt tggcgtcaaa ccaatacagc gtttctagtg agacatacgc 2340241 ccaaatgacg ccgagaatca aactcagcag cagcatcgga accccaatga catttaaaac 2340301 atacgccata taatcaagct tagataaatc ttctattctc aacagccatt ttccccactt 2340361 tttctttttc agcagatgat attgaaacat atatagcaca gaaaaaacga aagaaaggga 2340421 aaaagcgccg tatgaaagaa tcgccattgt aatatgaatc accaaaagct cggatacaag 2340481 ctgcccggaa aaagcagctg actgctgctc tgtcggtgaa aatgtgtgaa tggcgatcat 2340541 agaaaatcct ataacatttg taaaaaacac gataaagtca acacgtaaaa gctttgtcag 2340601 tacaagtgac agcgtgacaa gcacccaggc ataaaaataa agtgcctctg tcacatttaa 2340661 taccggaaac cgccccgtca cccacataaa ataggccaaa tacacggttt gcagagtcca 2340721 gacaatagaa agcaaccaga aggccatttt tccagccttc cggttgtgtt gaagaaaatc 2340781 tataaaataa aagagtacac ttaacgcgta aatgacgatt gtcccctcat taagtcttgc 2340841 cattgcagta tcaatcattc agctttcact cacttacaag tgggctaaag cccgcttttg 2340901 attcagcctt cttaaaagag tggaccttct ggctgctttc aacggttttc atcatttgac 2340961 ggcccgcagc ttcttcaata tcaaaaatct gcataaacaa cgcgagcttt tcttcagaat 2341021 cagcatctgc cgcaagctct ttcaccttta aaatcggatc acgaagcatt tggttaataa 2341081 tacttttggt gtgtttgttc aacagttttt tctctcttgt gcttaagtga ggcagcttac 2341141 gctcaatgct gtccatcgtt tctgactgga tggcaagcgc cttttcgcgc aatgcagaaa 2341201 taacaggcac aacaccaagt gtattcatcc attgtttaaa ttccacaatg gtttcttcaa 2341261 ttaacagttc aactttttca gctgtttctc tccgctcttt catgttcgct tctacaatgc 2341321 cttccagatc gtcgatatca taaagaaaaa caccttcaag atcattcagc gccggatcaa 2341381 gatctctagg cacggcaatg tcgaccataa acagcggacg tcccttgcga agcttattcg 2341441 cgttttccat catctctttg gacacgacaa attcacttgc accggttgaa ctgattaaaa 2341501 tatcagcctc cgcaagcgcg ctttcaagct gattcaagct tctcgcttca cctgaaaaac 2341561 ggtctgcaag ctccttcgct ttcaagtatg ttcggttaat gacagtgacc ttgccgattc 2341621 cctgtccgtg caggttttcc gcagcaagct cgcccatttt tcccgcaccg agaatcaata 2341681 tgtgcttgct tgaaagattt ccgaagattt ttttggcaag ttcaactgca gcatagctta 2341741 ctgacaccgc atttgagcca atgtctgttt cggcgtgagt ccgtttgccc actgtaactg 2341801 cctgcttaaa cagctcatta aaaatagtcc cgatcgtttt ttcttgctga gctgttttaa 2341861 agctgtcgcg tacctgtccg agaatctgcg tttcgccaat caccatagaa tcaagtccgc 2341921 aggctacacg gaataaatgc tcaacagcgg catcgctctc ataaaacgtt aagaacggtg 2341981 acagctcttc tttgcttaat tgaaaccaat cagctaaaaa cttttttata taataacggc 2342041 cggtatgaag ctggtcgact accgcataaa tttcagtgcg gttgcaggtt gagacaatga 2342101 tgttttcaag aatgcttttc tcttctttca gctgcaccat tgcttctgcc agctcattcg 2342161 gctgaaaact tactttttca cgtatctcaa taggggcgga tttataatct actcccacaa 2342221 caagtatatg catcgctcta attacacccc caacacccaa tcttaattta taatcattct 2342281 aacatagaac tcattattta taataattat aacatagttt ctttcacaaa atgtgaacag 2342341 attttaaaat tcttatgcta tattagaaaa agcttcaggg aaaagaagca ttcctattga 2342401 caataccaaa aacagcagaa atttactaca catcagctct aaaaaacaag aaggtgatat 2342461 gcatgaaaca aaaatcaatt ttattccctt gtctgctgct tgccgcttct gtatatgcat 2342521 ggctagaaag cggccaagcc gaactgtttt cagggcagga tcaatggcct gttctcctca 2342581 tgctgttagg cgcagccttt gtatatcaag gaaaaaaaga agccgtcaca ccccattttt 2342641 ttatcggttt gcttctcttc gggatcggtt tacacttttt tgccaagccg aaatgggtat 2342701 ggtggccgga tgattttgaa atgctcctct ttatgatcgg cttctcactt ctcgtttcaa 2342761 ccgttcaaaa aaaagaatat gtatatgaag ctgtgtcgat gatttgtttt tccctgtttt 2342821 tgtacttttt caaacaaatt atggcatggc ttgagtctgc gcatattcca acagcgcttc 2342881 tgaaggagta ttggccgttt gtctttattg gaatcagttt attgttatta ttgataaaac 2342941 gaaaaaaatc tatacgataa ataaaaccgg tagaggatcc tctaccggtt tatcattttt 2343001 ttgatcgctc cccaagcttc gtcttttccc tttttcgttt ctgaagaaaa gaggatcagc 2343061 tcgtcttccg gatcaatatt taatgtttgt cggacaacct tcgcgtgttt gtcccattta 2343121 cctttcggga tcttatccgc ctttgtagcg ataacaataa caggaatgcc gtaatacttt 2343181 aaaaattcat acatctgtac atcatcatta gatggcgcat gccgcaaatc aacgatctgc 2343241 accacagctt ttaattcctc gcgtgtcgtg atataggttt caatcattct gccccatgct 2343301 tcacgctcag actttgacac tttggcaaaa ccgtagcccg gcacatccac aaaatgcagc 2343361 tcatcattga taatgtagaa attaagcgtt tgtgtttttc ccggctttga tgacgttctc 2343421 gcaagatttt tgcgattgat taatgaattg ataaaagacg attttcctac gttcgatctt 2343481 ccggccaatg cgatttccgg aagcccccct tcagggtact gttccggttt tactgcactg 2343541 atcacgattt ctgactttgt gactttcatt tcttctctcc tactaaggca tgttccaaaa 2343601 cctcgtctaa gtgggacgcc aatataaatg tcagcccctc cctgacgctt tccggaatat 2343661 cctctatatc tttttcatta tctttaggcg caataatggt cgttaatccc gctctatgtg 2343721 cgccaagcgc tttttccttt aagccgccga tcggcagcac gcgcccgcga agcgtgattt 2343781 ccccagtcat gccgacttca cgcgaaaccg cccgtcccgt taaagcagaa acaagcgctg 2343841 ttgccatcgt aataccggct gacggaccat cttttggcac cgcaccctct ggtacatgta 2343901 tatgaatatc atacttctca tgaaagtcag gttcaatgcc aagttcttct gttttggatc 2343961 gcacatagct gaatgcagcc tgagcagact ctctcataac atctccgagc tttcctgtca 2344021 ggattaattt cccttttccc ggtgaaagcg atacttcaat cgaaagcgta tctccgccaa 2344081 cggttgtata cgcaagccct gtcactacac caacttgatc ctctgtttca gcttgtccat 2344141 atctgaaaat gcgttttccg ataaaatctt gaaggttctt ctcagtaacc gtaattcgtt 2344201 ttcgctcttc agcaacaatg gcttttgcag ctttacggca aattgcggca agctggcgtt 2344261 caaggcttct tacacccgct tctctcgtat agtaacgaat aatatcaaga atcgcctgat 2344321 cacgcagctg aagattgctt ttcttcagcc cgtgttcttt gatttgcttt ggaagcaagt 2344381 gatcctttac aatttcaagt ttttctattt ctgtgtagcc tgcgatatta ataatttcca 2344441 ttctgtctct gagcgggccc gggattgtgg ccaaattgtt cgccgttgcg ataaacagca 2344501 ctttggataa atcaaaggtt tcttcaatat agtgatcact gaagctgctg ttttgctctg 2344561 gatcaagcac ttcaagcata gcggatgatg ggtctcctct aaaatcagat gacattttgt 2344621 caatttcgtc taataagaag accggattca gcttgcccgc ttttttcatc ccttgaataa 2344681 tacgtccagg cattgctccg acataggtcc gtctgtgtcc gcgtatctct gattcatccc 2344741 gaactcctcc gagtgagatt ctgacgaatt tgcgtcccaa gctttttgca attgatttgg 2344801 ctaaagacgt ttttccgaca cctggaggtc ctgccaaaca gagaatcggg cctttcaggg 2344861 attttgtcag cttctggaca gccaaatatt ctaaaatacg ttcttttact ttttcaagcc 2344921 cgtggtgctc ttcgtccaag agacgtcctg cttctttcaa atcaagctta tcatctgttt 2344981 catccgtcca cggaagagca accagccagt cgatatagtt gcggatcaca gagctttccg 2345041 cagaacttga cggaattttt tcatatctgt tcaattcttt aagcgctgtt tctttcacat 2345101 gatcaggcat gcctgcttct tcgatttttt ccgtcagcgt ctgaacttcg ccagttttgc 2345161 cttctttatc gccaagctct ttttggatcg ccttcatttg ttcacgcaag tagtattcct 2345221 tctgcgtacg ctccatcgaa cgtttgacgc gctggccgat ttttttctca atctccagca 2345281 cttctttttc attattaata aaatcaatga ccttgttcag cctgtctttg acatcagccg 2345341 tttctaaaat atcctgctta tcctttagtt taaggggcag atgagaagca acgatgtctg 2345401 ccattctccc cggctcttcg atatcagtaa ccgcagcgta cgtttcggcc gagatttttt 2345461 tagaaatttt tatgtactga tcaaagtggt ctagcaaagt ccgcatcaat gcttcgtctt 2345521 ctgtatcttt tgaatcatct tcatgaataa gttgaatgtc aaccgacgtg taatcctcgt 2345581 gttcattgta tttgacgata tgggcgcgct tgaggccctc caccaacaca cgaatcgtac 2345641 cgttcggaag cttcagcatt tgcttaattt ttgtataggt gccgacagtg aaaatctcgt 2345701 cttcaccagg ttcgtctatc gaaatatcct gctgagtggc taaaaatatc atatgatcat 2345761 gcatcattgc ctgttcaaga gcctgaaccg acttgtcacg tcctacatct aaatgcaaaa 2345821 ccatcgtcgg gtacactaat aaacctctta aagggaggag cgggatgctg cgttttaatt 2345881 cttctgccat gtgactgaca cctccgtgac tttagtatga accattataa tacaactttt 2345941 tcatccttgt acaataaacg gcatggttcc attttctata aaacagtctc ctcgtagtat 2346001 accctttctt tctgatatga aaaaggaaaa gatgtccttc atgaaaaaaa ccctattatc 2346061 aaaatagggt ttaaacggat tctttattga tttcgatatg aaacggtttt tgttccgttg 2346121 gcggattcac caaaatttca tcaagcactt cttggaacgt cttcactgca ataatctcga 2346181 tcccgtcaat ctgctttaag atggcctgct gattttcata tgggataatc acctttttcg 2346241 caccggactg cttggccgct tttattttcg gaatgacgcc tccgatgggt ttcacaagac 2346301 cgttcaggct gatttcgccc gtcatcgcaa cggtattgtc aataggaatt ttgtgtatcg 2346361 ccgagaaaat ccccgccgcc atcgcaatgc ctgctgacgg cccatcaatc ggaatccctc 2346421 ctgggaaatt gatgtgaata tcataatcag aaggcttcat tcccattgtc cggagcacgg 2346481 ttaatacatt ttcaaccgaa cccttcgcca tgctttttcg cctgatcgat tttgattggc 2346541 tgccgatgct ttcttcttca gctattcctg tgatgttaat tgatccttta tcttgagccg 2346601 cggttacact tacttcgatt tccagaagcg atccgctgtt aggcccatag actgcaagcc 2346661 catttacaat gccaacctgt ggttcaacac cgattttttg ctcgtgcttt ggagtaagct 2346721 gactggagtg aatgacccat tcaatatcct caatcgtaat gtcctttcga ttctccgtta 2346781 cagccatccc cgctgcgatt tgaatcatat tgacggcttc ccgcccgttc cgcgtgtagc 2346841 tggtcaaaag atccagtcct tcttcggaga tatttttttc aattttatcc gctgctgttt 2346901 tggcaaccgt tttcagctcg tccttttcaa gctcgcggaa aaaaacctcc aaacagcggg 2346961 accggatagc tggcggaatt tcgtttggca ttctcgtggt cgcgccaatc aagcgaaaat 2347021 cagccggcag cccattttga aaaatatcat gaatatgatt cggaatttgt gtattttcct 2347081 cactgtaata cgcactgtct aaaaagactt ttctgtcctc aagcaccttc agcattttat 2347141 tcatttgaat aggatgcagc tcccctattt catcaataaa cagcacaccg ccatgggcat 2347201 gggtgacagc tccctgcttc ggctgcggaa tcccagcctg tcccatcgct ccggcccctt 2347261 ggtatatcgg gtcatggaca gagccgatga gcggatcggc aattcctctt tcatcaaaac 2347321 gggctgttgt cgcatcgagt tccacaaaga cagcctgctc tttaaacggt gattgtttat 2347381 gtttttttgc ttcttccaac acaagccgcg cagcagccgt tttcccaact cccggtggcc 2347441 catagacaat cacatgctga ggatttggcc cgcataaagc cgcctttaat gctttaatgc 2347501 cgtcttcctg tccgacgata tctttaaagc ttttggggcg gaccttctca gataatggct 2347561 cggacaagct gatagcgcgc attttccgaa gctgctccat ttccttcttt gattctttat 2347621 ctatcgtgac cttttgtgtc ctttgatttt taagcaaatt ccaaaaatac aaaccgatga 2347681 tgatcccaaa aaacagctga ataaataacg cgatccctgt ccaactcatg gtggtccctc 2347741 ctgaaaaaca atttatgtat ccaattcatt cctctgattg ctagtatctc ccatagaaga 2347801 cgggaataaa cgtttttccg gaagagttgc atgcaaaaaa acctcctgag tgttaccact 2347861 caggaggttt gtgcttatct ttatgcagat gttttatctt ggcttacctc agtgccgtct 2347921 tttaataaga ggcgaggagg ctctccgtgt gtcacagttg ccccggtgat tacacatttt 2347981 tcaatgtcat cacgagaagg cagctcaaac atcacatcaa gcatgatgcc ttcaatgata 2348041 gaacggagtc cgcgtgctcc agtcttgcgt tcaattgctt ttttagcaat ttcagaaagc 2348101 gcttcttctt caaactcaag ctcaacgttg tcaagctcaa gcattttctt gaattgctta 2348161 acaagagcgt ttttcggttt tgttaagatc gcaaccaatg cttcttcgtc aagcttttca 2348221 aggcttgcaa taaccggaag acgtccgata aattcaggaa ttaacccgaa acggagcaaa 2348281 tcttctggaa gcacttttga aagaagatct tctttctcaa gatcagcagc tttattgtcg 2348341 gcaccgaatc caatcacttt ttggcctaaa cggcgtttga tgatttgttc gataccatcg 2348401 aaagctccgc cgcaaatgaa caaaatattt gttgtgtcaa tttgaatgaa ttcttgatga 2348461 ggatgcttac gtccaccttg aggcggtacg cttgccactg taccctcaag aattttaagc 2348521 aatgcctgct gtacaccctc acctgacaca tcacgtgtga tagacgggtt ttcagatttt 2348581 ctagccactt tatcgatttc atcaatatag ataatgcctt tttcggcttt ttccacatca 2348641 taatcagcag cttggatgag cttcaagaga atattctcta catcttcacc cacgtatcca 2348701 gcttcagtca aagatgtagc gtccgcaatc gcaaacggca catttaaaat gcgagccaat 2348761 gtttgcgcca gaagggtttt accgcttccc gtagggccga ttaatgaaat attacttttt 2348821 gaaagctcaa catcatcaac tttgctgttg gagttaatgc gcttatagtg gttatacaca 2348881 gcaacagcaa gtgatttctt cgcttgatct tggccgatga catattcatt caaaatttcg 2348941 cgaatttcct gaggctttgg tacgtcttta aattctactt cttcttctgt tccgagttct 2349001 tcctctacaa tttcagtgca gagttcgata cattcgtcac atatatatac accaggtcca 2349061 gctacaagct tacgaacctg atcttgtgtt tttccacaga acgagcattt taattgtcct 2349121 ttttcctcgt taaatttaaa cattctttca ccccttaatc ttgtctcact ttttctttta 2349181 ccggcagagc aaaagaaaat gattcttgaa acgaacgagt atgtattgca ttttaccata 2349241 ctttccaaaa agacggtaac aatgtgtttc tgacttgcac attctatatg tatgacaaaa 2349301 aacagccctg cattaactat attgccccaa gaaaaagaga taactcataa ttgtacaaaa 2349361 caaggcacga atgattcgcg ccctgtttta ttagtactat tattatgcac catattaacg 2349421 gttttctaca agaaaatcaa ttgctttgcg aacttttaaa tcttctttca tcgcgtcagt 2349481 agaaccgatg gcttgtttaa tattttcaac aggcatgttg tatgcttcag ccatttttgt 2349541 aagctcagca tcaacttcct catctgatac ttcaaggttt tccgctttcg caatcgcctc 2349601 aagagtcagg ttagatttta cgcgtttttc agcatcttct ttcatttgct ctttaagcgc 2349661 agcttcatct tggcctgaga attgagtgta aagctcaagg ttcatgcctt gcatttgcag 2349721 acgctgttcg aattctttca gcatgcggtc aagctcagtg tcgaccattg cttgaggcac 2349781 atcgatttca gcattttcag aagctttcag aacaagctct tcacgcaatt tagcgtcagc 2349841 ttcgttttct tttgcttctt ctaaacgttt ctttgttttt tcagttaatt cagcaagtgt 2349901 ttccacttct tcatcgatat cttttgcgaa ttcatcgtca agctcaggaa gctctttcgc 2349961 tttgatttcg tgaattttca ctttaaacac agctggtttg cctgcaagat cttcagcgtg 2350021 gtactcctca gggaatgtca cttcaacatc cttctcagca cctgcttcaa ggccaactaa 2350081 ttgatcttcg aagccaggga tgaatgaacc agaacctact tctagagagt agttttcagc 2350141 ttttccgcct tcgaaagctt cgccgtcaac gaatccttcg aaatcaagaa caactgtgtt 2350201 tccttcttca acggcgcctt cttcttttac aacaagctca gcttgacgct cttgaagggc 2350261 ttttagttcg ttttgaacat cttcgtcagt tacagttgtg tcgtcttttt caatgcccag 2350321 gcctttgtat tcgccaagct tcacttcagg ttttactgtt actttcgcag tgaagattaa 2350381 gctttcgcct ttttcgattt tttcaacatc gatttcagga cggtctacag gctcgattcc 2350441 agcttcttca accgctttag ggtattctac aggaagaaga atatccaaag catcttggta 2350501 aagagcttct acgccaaagc gctgttcgaa taatccgcga ggaattttac ctttacggaa 2350561 tccaggaatt gaaacttgtt ttactacttt tttaaatgca tcatcaagtg ctgttttaaa 2350621 cgtttcagca tcaacttcaa ccgttaaaac gccttcgttg ccttcttgtt tttcccattt 2350681 tacagacatg tgtttccctc caaaaatcta ttcaggttgt gtcggtcttc cattctaaag 2350741 caatcattcg gcttcgtcca acaaaaacaa agctgccaaa gatcagaatc attatgtata 2350801 gatgttaata atgaactgca aagcctgtcc aaccgtattt cttataaccc gttatacaca 2350861 aatacaacca ctatattata acataacaca tagcgctttc aactatatgg cgcgatttac 2350921 aaataagaaa tttcttcaat atcttttaac attgtgcaag cttcatcgag ttctctgtct 2350981 gtaaattcat acatcatatg aagttcttcg ctttcaattt caatcccgtg catctcgtaa 2351041 ccgactttat gaagggcagc cgcccaaagg tcagccgaca gcaatttcgg ctggaacgga 2351101 tataaaacgt acaaatgtct tctccacaat tcttctactg ctgcatataa ggttggattt 2351161 tcatttccaa gtgtctcatc tagcaccctg agaacacggt gaagaatcgg cgcggcatca 2351221 ggcggaacaa tctctgacgg ttcaattgtc aacgactcgc caaatttact aatgtgtaca 2351281 ggtttactgt actcatgctc agccaacagc atgacaatca tcgttttgat aatcggatgg 2351341 gctgaggggt cttggaggat tgttttgagc aatcctgtat actttgctac gttacggtct 2351401 tttaaggaat gaatgagatt catttgctcc tcagggcttg ccagcacttt ctcggtgtca 2351461 attgtatcct catattcttc ggcccaagcc tcgtcctcac gatccggatc ggtcattttc 2351521 cggctgaaat ccagcagctt ataaaattgc tcggcacttt ctgccggcag ctgattttct 2351581 tccaaaacgg cttcaatggt gcttttgact tcttcgtact ttttgagctg aattaagatg 2351641 gtcatgtaca cctgcaaaac cgtaaaataa tggccataac cttctttgag catcttctcg 2351701 cacacgcttt ctgcctcttc cagctcgccc agctctaaaa agcagatggc catccctaag 2351761 tgaagatcgg attcagtatc atcatatttc atcgcttctg aaaacagttc aagcgcttct 2351821 tgatactttt tttccttgag tgatgacatc cctttttcca caaggcggtc tttcagatga 2351881 ggaaaaggaa taatttttgc gtttttcttg tcatgcgtca tacctatatt cctttcaggc 2351941 atttattttg ttcaagtgta tcaacacctg tgaacaaaaa caagaaatga aaggtttcac 2352001 caggcaaaaa aagccgccgg acaaataccg gccgcttttt caggcttgaa gccaagagct 2352061 tctttgtgat tcaaattgct tgatttcatc ttccagcagc agcgttaatg aaatttcatc 2352121 atatccgttg atcagcatct ctttccaatg cggatcaact tcaaatgaaa tttgattgcc 2352181 ttcactgtca tgaatcagct gattttcaag gtcaacagtc atttgcaatg actggttttc 2352241 atactggccg acaagctgtt tccaattgtc atatggcatg cggatcggaa gcatgccgtt 2352301 tttaaagcag ttctgatgga aaatatcagc gaatgacggc gcaatgataa ttttaaaccc 2352361 ataatcatca agtgcccacg gagcgtgttc acgcgatgac ccgcagccga agttttctcc 2352421 tgctattaaa atggaagctc cttgataaac aggctggttt aattcaaatt cagggttcgg 2352481 ttcaccattc gcatcatatc tccagtcaaa gaatgcaaaa cgtccgtagc ctgttctttc 2352541 aatcctcttc aaaaattgct taggaataat ctggtctgta tccacattga tccgatttaa 2352601 tacggctgct ttccccgtat gtgatttcaa aggttccatc tcgcgcactc cttacacaac 2352661 tgttttttcc tgataaaact ttctgacatc aacgaagtgt ccgtgaatgg cagccatcgc 2352721 agccattgcc gggctgacga gatgtgttct tgcacctttt ccttgtctgc cctcgaagtt 2352781 gcggttagag gttgatgcac agcgctctcc ctcaggaaca acatcattat tcatactcaa 2352841 acacatgctg cagcctgact ctctccattc aaatccagct tccaagaaaa tctggtcaag 2352901 cccttctttt tcagcctgaa gcttcacgct ttgggatccg ggcacgacga tggcccttac 2352961 gctgtcagct accttcttcc ctttgatcat gtcagcagcc tgtcgaaggt cagtcatgcg 2353021 ggaatttgtg caggaaccga taaatacgtg ctccacttta atgtcttcaa ttttttggtg 2353081 aggagtcaat cccatatatt cataagcacg aatcgcttct tttttatcgt cttctgcaga 2353141 aaagctttcc ggcgcaggaa cttcagaatc gacaggaaga accattcccg ggttaatgcc 2353201 ccatgtcacc ataggggaaa ttttgttgcc gtcaaggacg atagatttat cgtaaacagc 2353261 gcccgggtct gtgcgcagcg ccttccattc ctctacggcc ttgtcaaatt cttcgccttt 2353321 tggcgtgtac ttgcgatttt tgcaatattc aaacgtcacc tcgtcaggtg caatcaaacc 2353381 tgctcttgct cctgcttcaa ttgacatgtt acaaacagtc attcgttcat ccatcgtcat 2353441 atttctgaat acttccccag tgtattcaat gacgtagcct gtgccgaatt tcacaccgta 2353501 tttgccgatg acagcaagga tgacatcctt tgccgttacc cctttttgaa gcgttccatc 2353561 tacgcgcact tcaagtgttt ttggacgctg ctgccaaagt gtctgtgtgg aaaggacatg 2353621 ttcaacttca ctcgtcccga ttccaaatgc aagagcgccg aaagcgccat gtgttgatgt 2353681 atgactgtca ccgcacacaa tcgttttccc tggaagcgtt aagcctagtt caggtccgac 2353741 gacatggaca atcccttgat ccacactgtg aagatcggca aggcgcacgc caaattcctc 2353801 acagtttctt tcaagcgccg ttacctggcg tttcgcaact tcatccttta tctcaaaacg 2353861 attgacagtc gggatgttgt ggtccattgt cgcaaatgtg ttttggggtc ttctgacctt 2353921 tcttcccttt tgtctcaagc cttcaaatgc ctgaggagac gtcacctcat gaatgaggtg 2353981 caaatcaata tagagaagat ccggctttcc ctcaccatgt tttacaatat gctgatccca 2354041 aatcttttcg atgattgttc gaggcatcat cttttatttc ctccctctac ctagagctaa 2354101 gaccgcttaa cgtaagctgt cacacattag aaattgtatt ttcactcatg attgctgcct 2354161 taacttcctc tgtaatggcc tgagtgctgc tgaactcttc actccgtgcc aagtctcttg 2354221 ttctttttcc agaagccaag actttgttta ccgcatcttc tacagctttc gcttcctctt 2354281 caagcccgaa agatgttctc aaaagcattg ccgctgacaa tatggctgcg aacggatttg 2354341 ccatcccttt accggcaata tcaggcgcgg agccatgaac aggttcaaac agatgaaggc 2354401 cagagcttga taggctggct gacgggagca ttccgagcga gcctgtaagc atggacgctt 2354461 catcgcttaa aatatcaccg aacatatttt cagtcaccac gacatcaaat tgattcggtg 2354521 cataaattag ctgcatggcc gcgttatcca caagcatgtg ctcaagcttc acatcaggaa 2354581 attcttgtgc aacgtcctca gccacttcac gccacagccg gcttgattca agaacattcg 2354641 ctttatctac agaggtcact ttgccttttc tggctgccgc cattttgaag ccctctctga 2354701 tcactcgttc aatttccgtt cgcttataaa acagtgtatc tactgcttcc tgctcacctt 2354761 cagtgtttac ataacgtttg ctcggctggc cgaaatacaa gccgcctgtg agctcacgaa 2354821 cgataacgaa atcaacatta tctatatatt cttttttcaa aggcgaagcg tcagaaaggc 2354881 tttcaaatac cttcacaggc cgcaaattcg caaacaaatc aagctgtttt ctgatgctga 2354941 gcagcccttt ttccggtctc agttccgaag gattttgatc ccatttcggt ccgccgacag 2355001 caccaagcaa tatcgcgtct gcatttttac aagcagcaac ggtttcctcc gggagggggt 2355061 tatgatgttc atcaatagcc gcccctccaa tcaggccata ttcaaattca aattcatggt 2355121 taaagcgttc ggcaacactt ttcagtacgt ctgtcgctga ttctaatact tcagggccga 2355181 tcccgtctcc gggcaataga gcaatacgtt tcttcaagtt aaccgttctc ctttctttta 2355241 tgatccgaca gctgtgtggt ttttcaatcc gctcatattc gactggaaaa ccaattgacg 2355301 gtttactgcg ttcaaatagg ctttcgctga tgcttctaat acgtcttgcg ctatgccccg 2355361 ccctgctgat tcttttccgt tcaccaaaac tcttacatac acctgggcaa atgcatcttc 2355421 gccttttcta ttagactgaa tgcggtagtc taagagctcc acatccttat cgatgcagcg 2355481 ctcaagcgta ttgtagattg cttccacgct tccagctcca gttgcagctt cctgaataag 2355541 ctgtgcgttt tcttgatttt tcaaagatag agtagccgta gggacctgac ttgttccgta 2355601 atgtacttgc agagaaagaa attcataccc aatcttgcga tctgttactt tttcttctaa 2355661 aataagagaa acaagatcct catcagtgat ttcttttttc ttctcagtca actctttgaa 2355721 catcgtaaag aatttattaa tctcttcact gtcaaattgg aatcctaaag cagtcagccg 2355781 gtctttaaat gcgtggcgtc cggaatgttt acctaggaca agcgcatctg cggttacgcc 2355841 gacaagctcc ggtgaaataa tttcataagt cgatttttcc tttaaaaagc cgtcctgatg 2355901 gatgcctgat tcatgagcaa atgcattatc tccaacaacc gctttgttgc gcgggacagc 2355961 catgcctgtc agtttgctta ctaaatcact tgttctctta atctcgttca gcgtaatacc 2356021 tgtttcgact tggtagaaat cttttctggt atggagggct acggcaattt cctctaatgc 2356081 cgcgtttccg gctctttcac cgatcccgtt cacagcgcat tcgatttgat cagcgccatt 2356141 ttcaatcgca gcaagagagt ttgcgactgc cattcccaaa tcatcatgac agtgggctga 2356201 aagctttgct ttgtgaatgt tcggaacgtt ttctttcata tatttaaaga tatttccgta 2356261 ttccgccggg gccaggtagc cgacagtgtc cggaagattg ataacactgg cgcctgcgtc 2356321 aatcactttc tcgacgattt ctgctagaaa cggcagttca gtgcggcagg catcttcagc 2356381 tgaccattgc acaatcggaa aacgttcttt tgcgtatttc accattccaa ctgctctttc 2356441 aatgacttgt tcacgtgtca ttttcagctt gtgcttcaaa tgaatgtccg atgtcgcgat 2356501 aaatacatga attcttggtt gagcgccatc ctttaacgct tcccaagcag catcaatatc 2356561 accttttaca caacgggcca gaccagttac tgaacaattt ttaatggttc ttgcgatttc 2356621 ctgaacagct aaaaagtcac ctcgggacga agcgggaaat cccgcttcaa tgatgtctgc 2356681 cccgagtctt tcgagctgct tagctatggc aagtttctcc tgtgtattca agttcactcc 2356741 aggggactgt tcaccatcac gaagcgtcgt atcgaaaaaa ttaattttgc gcaacggaga 2356801 ccaccgcttc cttcttcttg ccttgtttca caaacggcat catttcacga agctttcttc 2356861 ccactacttc gatttgatgt tcgttctcgc ttgcattgat agcgttgaaa cgaggacggt 2356921 ttacttggtt ttcgacgatc cactcttttg cgaatgtacc gttttggata tcttttaata 2356981 cttctttcat agattctttt actttggcgt ccacaacgcg agggcctgat acgaaatctc 2357041 cccactgtgc tgtgtcagag attgaatatc tcattcctgc aagtccttct tcgtacataa 2357101 ggtctacgat taatttcagc tcatgaagac actcgaagta tgcaagttca ggctgataac 2357161 ctgcttcagt taaggtttca aatccggctt tgacaagcgc gcttaatccg ccgcaaagaa 2357221 ctgcttgctc accgaacaaa tctgtttctg tttcttcttt aaatgtcgtt tctaatacgc 2357281 ccgctcttgc gccgccgatt cctttagcat aagcgagggc tttgtctctt gcttctccag 2357341 tcacatcttg atagattgcg aacaatgcag gtacgccagc tccttgctca tatgttcttc 2357401 ttaccaagtg tcccgggcct ttaggggcca ctaagaatac atctacatcc gccggaggaa 2357461 caatttgatg gaaatgcacg ttaaatccat gagcgaatac taatgatttt cctgctgtca 2357521 attcatcttt gatttcagct tcgtatactt tttgctgctg ctcatccgga agcagaacca 2357581 tgatgatttc ggcttgggct gccgcttctt ttactgaaaa tactttatgt ccgtcttctt 2357641 gggcttgagt gaaagatttt ccttgtctaa caccgacgat cacgtctact ccgctttctt 2357701 taaggttcag ggcatgtgcg tggccttgcg aaccgtaccc gataaccgct actgtttttc 2357761 cagccaatac gttctctttg atatcaccgt tataatatac ttttaccatt tcaatctctc 2357821 ccttgttatg ttttatacaa tagatattgt tttattggat gacgcctttt gctgggttcc 2357881 cctcgcaaaa gccgttgtac ctgttctcgc gatttcttta atgccataag gttttaataa 2357941 ctcaataagc gcttcaattt tgttagattc acctgtcacc tgaacaacga tgctgtctct 2358001 gctgacatca acgacagagg ctctaaacgg ttctatgatt ccattaatct ctgttcttgt 2358061 tgaaggtgcg gagacaacct tgattaaggc cagctccctc tggacaatcg attgatttgt 2358121 gatgtctgtg actttcagca catcaatctg tttgttgagc tgtttcgtta actgttcaac 2358181 atcattttca ccttcaacat gaacgacgaa ggtgattctg gaaacgccgg ctgtttctgt 2358241 gtgtccaact gtaatgcttt caatgttgta atgccttttt gtgaatagac cggtgatccg 2358301 gtttaacacc ccggagcggt tcaccacagt caatgtgata attcttttca aggtttcacc 2358361 cccaccattt catgcagccc tttccccgga gccaccatcg ggaatacttt ttcttcgctg 2358421 gcaacccgca cgtcaatgac aacaggttct cttgatgtta atgcctcttc cagcttttcc 2358481 tttgcttccg cttctgatga aattctgatg cctttaatgc cgtatgcttc ggacaatttg 2358541 acgaagtcag gctgagaagc gaatttagat tctgaataac gttcttcata gaaaatttcc 2358601 tgccactgtc tgaccattcc gagacaagcg ttatttaaaa tcactacctt gaccggaaga 2358661 tttaattcgc gaataacatc gagttcttga agcgtcattt ggaatccgcc gtctccgaca 2358721 accgcgacaa cagtagcatc tttttcggcc agctgtgcgc cgatcgccgc cggaagaccg 2358781 aatcccatcg ttccaagtcc gcctgacgtg acccatttat ctgctttttg gaacggataa 2358841 aattgcgctg accacatttg atgctggcct acatccgttg cgacaatggc ctctcctttt 2358901 gtaaattgat gaatatattc aatcaatttc tgaggtttaa aaccttcttc ttcattatct 2358961 acataccaga gcggatactc ttctttccat tctgcgagct gttttttcca ttcgcttgaa 2359021 tcgctttgtt tgccgtcttg tttgatcagc tcctgcagga caattttgct gtctccgact 2359081 acaggaatct gtgttttcat gatttttccg atttcagctg gatcaatatc gatgtgggct 2359141 atctttgcgt ttctggcaaa gtgtttcagg tttcctgtga cacggtcatc aaaacgggcg 2359201 ccgatactga ttaatagatc acattcatga agggccatat tggctgtata agtaccgtgc 2359261 attcccgcca tccctaggaa aagcggatgg tcagccggga agcctccgag ccccaaaagg 2359321 gtgtgtgcca cagggatttg ctgctgttca gcataatttt ttaattcttc tgacgctttt 2359381 ccgtgcagta cgcccgcacc cgccaggatc accggttttt tcgcactgct cacggcttcc 2359441 acaagcttgc ggatctgcaa ataattcggc tctgttgtcg gctggtatcc cgggagattc 2359501 atctcatgat cgtagctgaa ttctccttca attgttgcta catctttcgg aatatcaatc 2359561 aatacaggtc cgggtcttcc agttgttgca atatggaacg cttctttaat gatgcgcggc 2359621 agatcttccg gctggcgaac ctggtagctg tgttttgtta ctggcatcgt aatccctaaa 2359681 atgtctgctt cctgaaatgc atcgctcccg attacagagg ttgctacctg ccctgtaaag 2359741 acgactaacg gcaatgaatc aatcatggca tcagcaaggc ctgtaacaag gtttgtcgct 2359801 cccggccctg acgtggcaat gacgacaccc ggttttccgg agacccttgc gtatccctcc 2359861 gctgcatgaa ttgctccttg ttcgtgacgg ggaaggatat gtaccaaccc tgaattgtat 2359921 agcttatcgt aaatcggaag cacagccccg cccggataac cgaagatcat ttctactttc 2359981 tcttttttta atgattcaat cagcattaat gctccgctca tcgtctgtgt acattcggca 2360041 gatgctgaat ccacctgtac attagtcccc attttagttc ctccttttgg attttcatcc 2360101 tttaaagatc atcttttcat tagctagata gctgattatt caataaaaaa agcccttccg 2360161 cccacaatca gccgcgcagt aactgcgata gctaaaaggg gcgaaaaggc ttttctttcc 2360221 gcggtaccac ccttgtttac ggcctgttaa tcggccgtct catggatatt tctatccgct 2360281 ttagtaacga gtgaatcaag ttcacccggc caagtcctac tgtcatttca gactggcact 2360341 ctgaggcgag ttcaccttgt aaagcttcgc cggttctcag ctaacccggt tctctgtgga 2360401 aaactttatc aaggctactt atcctcatct gcgcttttca tattcagcct tcggaacggc 2360461 tttccagctg ttcaagaagg tcgtttgttt ttcatttttt tagaatcata ctgcgatgat 2360521 tttcgcttgt gaagcttgca tttatctttt gttgaactca tattacgccg ctttggacgc 2360581 agtgtcaaca gcatttttta aaattattag acaattttga ttaatcaatc tatattgtat 2360641 acgctttcat tattggtaca aaaggaattg caaatgttaa aagtttttat aattttttta 2360701 ttaatctatc aagaatacac cagaattatt taattttata taaacatgga agattttata 2360761 acacgatatg gttcgtatat ggattgagtc tgacagatca tcttgcaatc catttcaatt 2360821 tcggataggc acttctcttg ttccctcggc atacattaat gatatcttgc aaagaaaagg 2360881 tgatacgatg aataaatcat ttgcagacat gcaaggattt cctgcgggct ttccaagctt 2360941 ccccaacttt ccgcagcagt actatcctgc tgtccctccc ttttaccagc aaagccagca 2361001 gccatttgga ggctacggat acggacagcc gttcagtcag gcatacagcc cgttaaccac 2361061 tccctctgga atgtactcct cattcccata cgcttcagga ttttacggac agcaattttc 2361121 aggtgcaggc tttagcggcc atggcggcag cttaagtgct ccagcgatac atgccggcgg 2361181 attcagcggg gcgccaggcg tacacggagg ctttagatat taaagaatac cacaagggcc 2361241 gaacatctat tgcggtcctt ttattgtttt aaaacgactt cacaagtaca gtcacatttt 2361301 ctgtctttat atttggaaac aggatggaat atgattaaga tgaattgaac gatattctgc 2361361 acaatccgta agttttcgag gaggaataaa attgcatata aaaatagacg atttaactgg 2361421 acgtcaggtg gtttcactgg tgaatgagca tttacatagc atgacgctta tgtccccgcc 2361481 agaaagcatt catgccttag gtctagaaaa actaagaggg cctgaaataa cattttggag 2361541 cgcatgggaa ggtgatgaac tagctggctg cggagcgcta aaagaactgg acacccggca 2361601 tggagaaatc aaatcaatgc gaacatctgc atcacattta agaaaaggcg ttgccaaaca 2361661 agttctccag cacatcattg aagaagccga gaagcgaggc tatgagcggt taagcttaga 2361721 aacgggttca atggcttcat ttgagccggc aagaaaattg tatgaaagct tcggtttcca 2361781 gtattgtgaa ccgtttgcag actacggtga agatccaaac agtgtgttta tgacgaagaa 2361841 attgtgagac ggctttataa ggatagataa gtgcagggga aggtctgtct tatctatctt 2361901 tttttatatt cacacatttt tcacctttat gatacacgcc aatgttttca attttgttta 2361961 attcaaagaa cagcgggaat tacaaacgac atgaacgata tcatgcaaat tcataaagga 2362021 ggagattgat atgaaaagca tagttggtgt atatgaaact ccgcaggaaa ccatcgcagc 2362081 gattgaaggc ttacttacaa aaggctatga ttctgatgac atttctgttg tgacaagccg 2362141 gcgagataca gattatttgg agtcacgtac aggaacagaa gtcaatcaag ctatcgatgc 2362201 acatcaggac gaatctgaat cttttttcga taaactgaaa gattatttca caatggatga 2362261 tactgctaca cacagcaaag cattatccga cttggatatt aaaactgatg aaatagacaa 2362321 gtatcaagaa gatttggatg acggaaaact tctggtagcc gtcgatacag atgcagatgt 2362381 aattgctcct attgataacg gcaatgccct ttcaggcggc ttttcaagca caaatgaatt 2362441 ggattataca acgaaagaag aaaaaacgat gccgctccgg gaagaacagc tgaaggtcga 2362501 taaggaagac gttcaaaccg gcgaagtaga aataggaaaa gaagtgaaaa cagaaaaaag 2362561 agatatggac attccggtga gacatgatga aatttatgtc gaacgccgtc cagtggatga 2362621 aaataaaacg gacgctgctc ccgtcaacga ttcggaagag atcagagttc caatcgttga 2362681 ggaaaagctg gaagtgacta aaaaaccggt tgtcactgat gaagtggttg tcggcaaacg 2362741 cactgttgaa gaaaatgaac atatttctga aactgtgaaa aaagaagaac ctcgtctgaa 2362801 taaagaagga aaagttgacg gcttggatga tgatccgtta aataacaaat gaaaatcata 2362861 gaccgacaac aaaaaacctc aaatcctaaa tggatttgag gtttttcttt tggtacgtcc 2362921 caggagagat tcgaactccc gaccgacggc ttagaaggcc gttgctctat ccagctgagc 2362981 tactgggaca cgttttgttt ttttgttttt cgctttaact atcagcgaca agatttatta 2363041 tatatgggat gcaataataa gtcaacggtt ttttagaatt tttttcatga ggaagaaaat 2363101 tttcttcctc atgacatttt catagtgtga ctcgattttg cagatcctca atttcattgc 2363161 ctgcttggtc gtaaaaacgg actgtcgcag catcattttc taatgtcagt atagcatagc 2363221 tttctgtcct gcgcaccctc ggaagccgga tgctgcctgg gttaatcatc agttttccgc 2363281 gcagcacttc gcttcccgcg atgtgcgaat gcccgaagca gataacatcc gccccgagct 2363341 cctctgcacg atagtatacg tttaacaagg tctgttttat accgtgaagg tggccgtgtg 2363401 tgactagtat ttttcttgag ccggcagtca gaagaagctc gtccttaaaa tcgccggcaa 2363461 aatcgcaatt gccttttaca accgcataag gctccaatgc aggatgcctc gtctcaagct 2363521 cagagtcccc gcaatgaatc atgagatcaa cttctgcctc atgccgtttc gcaatggttt 2363581 ggagttcttc ttcaagccca tggctgtcac tgataatcag cacgttcatg tacaagcttc 2363641 ctccttatgc ctccaaaagc ttagacagct ttttaagcgc gtcagcccta tggctgattt 2363701 tatttttttc atcacttgtc agttcagcca tcgtcttatc tttatctttc acgataaaaa 2363761 ttgggtcata gccaaagcca tattctcctc tcggttcttc agcaatatac ccttcaacat 2363821 ggccttcgac tgtttttgtt tcctctccgg gaatactcac ggccagtgcg cagcggaaac 2363881 gggcggtgcg ctgttctttt tcgatacctt tcagctcgct gagcactttt tcgatatttg 2363941 cctggtcgtc tttctgttcc cctgcatagc gggctgaata aaccccgggt ctgccgccaa 2364001 gattatcgat ggatagtccg gagtcatccg caatcaccat tttgttcact gctttggcaa 2364061 cagcttccgc tttcataatg gcattttctt caaatgtatg gcctgtttct tcaatttcct 2364121 ctgtgaatcc aatttcagct aaagatttga catcatagcc tcttggctca agaatttctt 2364181 tgaattcctt cacttttccc ggattatgtg ttgcaataat tgcttctttc atgatgatca 2364241 agcctttctg tctttatttc agttctggca gagaatcacc cagcacttct ttttgcttgt 2364301 caatcagctc ttggattcct ttttccgcaa gacccagaag accgttcaga tcctctctag 2364361 aaaaagttgc ctcttccccg gttccctgca attccacaaa acggccgctg cctgtcatga 2364421 tgacattcat gtcaacttca gcagaggaat cttcttcata atttaaatct aacaaaattc 2364481 cctgttcctt atcaattcca acagagattg cagcaagaaa atcagtgatc ggatttgtct 2364541 tgattgttcc tgctttgatc agcttgccaa tcgcaatcgc catagcaaga aatgcgcctg 2364601 taatggaagc tgttctagtt cctccatcag cttgaatgac atcacagtca atccaaatcg 2364661 tccgttcacc gagcttttcc agatctacaa cagctcgaag cgcgcggccg atcaggcgtt 2364721 ggatctccat tgttctgccg gaaattttcc ccttagaaga ttctctgatt gttctttggt 2364781 ttgttgcccg cggcagcatg ctgtactctg ctgtaatcca gcctttccct ccgccccgca 2364841 aaaacggcgg tacgcggtcc tcaacagacg cgttgcagat tacctttgta tttcccgctg 2364901 ttattagaac agaaccttcc ggatggctga taaaatccaa atcgaatgtg attggacgca 2364961 gctcatcgtg ttgtcttccg tcatgtctca tgttttacct ccgattgtat gtacataaac 2365021 catttttgtc ccggaattga ataaagaaag aggcagccgg aacgctaacc tctttcttcc 2365081 tagtatatca aaaatcccaa tttaaaaact acccgtattc acttgagatg gtctggagac 2365141 cggttctgtg agcttttcgc ctttttcatt taccagctct gattttccgt tcactttaac 2365201 agagacgctt tttacatccg gctgctccgt taacgtcagc acaatgctgt tcagcacttc 2365261 tgaagaaatc attttcgtct tctcatcggc gctgccgaat atagattgat tgaaatccaa 2365321 cgtcacgcgc ccgtctttga ttttcggttt gctgaccagc tttacatctt cactgaagtc 2365381 tgttaacagc ccgctcacct tgctcggccc tttagccaat tcattaatgg ctgctgtgat 2365441 gtcgtctttt tccgaattgt cgattcgttt ggtcaccggc acgtagtatt cactgtcttc 2365501 attttccgcc aaatagtaga ctgtcagcgg atgggtagca gtgagatcat ttacaccggc 2365561 tgtttccaaa ttaatgccgt ctttgcggct taaatcatct gagatcggcg tccctcctac 2365621 aggcatctcc ttcagttcat gcccgtttat tctcagcttc actttatcta tcgaactaaa 2365681 ttgcgtcagc gtccacgtca cagattgaac gattttctgt tcgtcttctt tcttataatt 2365741 tttgaactca ttagagaaat cagctatcgc cgttccatct tttttgatgt caacgttaac 2365801 ggtggtgtca gccggcaata cagctctgaa gccattcgga agaatttcag acacaggccc 2365861 gccctgtacg aggtattcaa gcgcctgctt agccgtgctc tcacttttag gaagaggcag 2365921 cgtttgcgca acaacatacc cgtttttatc aatgagataa agctccctca taacagtaga 2365981 tgaggcttga tccgcttttg cggtatcgct tttttcactt tctgtttttt tggctgctgt 2366041 tgtatttgaa ttggcacccg cttcatcgtt cacgaatgta acgtcttgag gcggatcaat 2366101 ttcctcggct gccttatcag attgaaacaa accgcatccg gataaaagca aggcagaggt 2366161 gagacaagtg gcaccaatga ctgcaggtcc ttttttcagc atacttttcc ctcctaagga 2366221 tgtttgtact attatgtata cgagcctctt taggaaatag accgaagaat tccggcaaaa 2366281 cagaaaaaaa cccgcaacat accgttgcgg ggaaaactat cttttaatcg gttcttgcag 2366341 tgagatacat tccacatgcc cgacttcatg gccaaaccaa tcgtctgcga tttttgcaaa 2366401 ctgatcacgc gcccctgttg tcaggaactg atgatccggg gcaatcggag actggttcag 2366461 cagcccttta taagagagaa ttgtgctgac ttcccgggct gtttcatcgc cggacgaaat 2366521 aatgtttacg tgctctccca tatatctttg aatggcttct tttaaaatag ggtaatgggt 2366581 gcagcctaaa atcagcgaat caattgatgt gtcttttaac ggatacagcg aggttttaac 2366641 aatctcgtct gctgttttgt cgagaaactt cccgctttcc acaaaaggca caagcagcgg 2366701 gcaggcaagg ttttcaacct tcaaatcagg gtttaatgcc aaaagcgctt cttcgtatgc 2366761 attgctctta atcgtattct ctgtgccgat gacaccgata tgctgattat ccgtcacttt 2366821 tatcgctgct ctcgcaccag gctggatgac tccgaccacc ggtataccga cgctgcgctg 2366881 gatgtcatcc aaagcgatcg ctgttgctgt attacaggcg atcacgagca ttttgatgtg 2366941 gtggttttcg agtaaataat tcgtcagctc ccacgtatat tgaagcacct cttcttcagg 2367001 gcgcggcccg taaggacacc gtttcgtatc cccgacgtag ataatatttt ctttaggtag 2367061 ctgtctcatg atttccttcg caacggttaa accgccaacc ccggaatcaa tgactcctat 2367121 tggttgttcc aacaaaatcg cctcattttc tcttcatttc atgctgcagt ttcatcaaag 2367181 atttttcgaa gatggctatt tcttcatctg taaacgattc gaacatatca cgcagatatt 2367241 cctgtctttt tgtaatgacc tcttggataa tccgttctcc ttcaggcagc agatgtatcc 2367301 tgacaacacg tctgtccgcc gggtccttga cccgctcaac aagctcattt ttttgcatgc 2367361 ggtcgattaa gtccgttgtc gtgctgcatg ccagatacat tttgcccgat aattcaccga 2367421 ttgtcatatc tcctaattca taaagccatt gcaagccgac aaattgcggc ggcgtaatcg 2367481 catattggtt aaggatttct cgtccttttt gcttaatgat cgcggcaatg tggcggagtg 2367541 acttttcaat atccgcaaca tgctccaaag gttttgatgt catttgtcca tccctcactc 2367601 aaggatctct tacgcacaaa agcgttccgt gtctattttc cttctttttt gaagaaaatg 2367661 caagactcgc aggagagaaa tagaggactt tagtcaaaca acatcaagaa ataaaattta 2367721 atttatgact tgcctacgtt ttgcacagca ttccaaatat ggtttcgaat gttccaaaca 2367781 aacagcaata accggctcct tccaaaagaa ggaataccgg caaggattaa agctctagct 2367841 cacccattct aagaagctca acaacggctt gcgaacgccc tttcacaccc aatttctgca 2367901 tggcatttga aatatggttt cgaacggttt tctcactgat aaatagctcg cttgcaatct 2367961 cctttgttgt cttatcttga acgagcaatt cgaacacttc tctttctctt ttcgttagca 2368021 gcggcttcga ttgaaattct ttctccttca agtattgtaa ccctccttgc taaggtgaga 2368081 gcgaatcaga aacgaatggg ttttgatata gtcgagatat catatgtaag aagggcgcag 2368141 gaggtgacgt ttacaagata attagtttat cgtgtatgaa gaagcgtttc tttctcctca 2368201 tccgtccagc tgacagcctt gccgctttcc tttgagactt gaaccatcac gactgccccg 2368261 gtgaagcagg gttcgccttc gaggttctct ccgagatagt gcaaggtaag agatgaactg 2368321 ccgactgcgc ttgttttcac atagatgcgc aactcttcat aaggcatgac ttggcgcaaa 2368381 taatcgcatt gctggcttgc cacgactgtc atggtctgtt tgttttcact catcatattc 2368441 agctttttaa aataagaaat ccgcacctcc tcaaaatata taaaaggggt tacattattc 2368501 atatgcccaa acatgtctgt ctcggaaaat cttacggata ccttattgaa aaaagaaaag 2368561 gatgttttcc attcttgaaa cggcatatca atataagcgg gaagcttcat cttttttcat 2368621 ctccttattg tttaaaaaaa cctctcccat gcggaagagg ttttttcttc ttatactctg 2368681 tcgcttccga agaaattgcg gaacgcttgt aagtttgtat ctctattcaa ggctgcaatc 2368741 gaagtggtaa gcggaatccc cttcggacag gattgaacac agttttgcga gttgccgcaa 2368801 tctgcaaggc cgccttcatc cattaatgct tctaatcgtt cagatttatt catggcgcct 2368861 gtcggatgcg cgttaaacag gcggacttgc gacatcggtg caggccccat gaacttcgat 2368921 ttgctgttca cattcgggca agcttcgagg cagacgccgc atgtcatgca ttttgataat 2368981 tcatatgccc attgacgacg tttttccggc attctcggcc ccggtcctaa atcgtacgta 2369041 ccgtcaatcg gtatccacgc ttttactttt ttcaatgaat caaacattct gctgcgatca 2369101 acctgcaaat cacgaacgac tgggaatgtt ttcattggtt ttaaacggat tggctgttca 2369161 agctggtcaa taagcgccgt acaagactgg cggggttttc cgtttataac cattgaacat 2369221 gcgccgcata cttcctcaag acagttcata tcccatgtga caggggttgt cttctcacct 2369281 ttgacattaa ccggattccg gcggatttcc atcagagcgg aaatgacgtt cagattcggg 2369341 cggtatggaa tctcaaattc ttcatcataa ggcgtgctgt cagctgtatc ttgacgtgtg 2369401 ataataaatc gtatggtttt ttgttcactc atgattattt cgccaccttc ttcttcgagt 2369461 aatcccgttt ccgaggcgtt atcagtgata catcgacatc ctgatactca aattccggcg 2369521 cttcatacgg gcttacatgt ttagccattg ttgttttgag ccattcatca tcattacgtt 2369581 caggataatc cggtttataa tgggcgcccc ggctttcatt acggttgtat gcgccaaggg 2369641 taatcaccct cgcaagctga agcatgttcg agaactggcg tgtgaacatc gctccctggt 2369701 tgctccattt tgtcgtgtca ttgatgttga tctttttgaa gcgctccatt aactcctgaa 2369761 ttttgtcatc cgttttcaaa agcttgtcat tatggcggac aaccgttacg ttcgccgtca 2369821 tccactcacc gagctctttg tgaagaacat aggcattttc ggttccgtcc atactcataa 2369881 tatcagccca tttttcttct tctttcttaa cgtgagcgtc gaataaagat gaagacatgt 2369941 cttccgctga agattctaag ccgtttacat atttcaccgc attcggaccg gccaccatgc 2370001 ctccgtaaat cgcagacagc agggagttcg ctcccaagcg gttgccgccg tgcatagaat 2370061 aatcacattc cccagccgca aacagtccag ggatatttgt catttgatcg taatccaccc 2370121 ataaaccgcc catagaataa tggaccgccg ggaagatttt cattggaagc ttacgcgggt 2370181 cgtctcccat gaatttctca taaatctcaa tgatgccgcc aagcttaata tcaagctctt 2370241 tcggatcttt atgagacaga tcgagatata ccatgttttc accgttaata ccgagcttct 2370301 ggttcacaca cacatcaaat atttcgcgtg tcgcaatatc acgcggcacc aggtttccgt 2370361 atgccggata tttttcctcc aggaaatacc atggtttgcc gtctttatat gtccacacgc 2370421 gcccgccttc accacgcgct gattcactca tcagtcttag tttgtcatcg cccggtatgg 2370481 ctgtcgggtg gatttgaatg aattctccgt ttgcataata cgctccctgc tgataaacga 2370541 ttgacgcagc agatcctgta ttaatcatgg agttcgttga ttttccaaag atgattcccg 2370601 gtccgcccgt cgccataatg acagcgtctg aacggaagga ttcaatttgc atgtttgtca 2370661 ggttttgtgc aacaattccg cggcaggttc tgtcatcatc taaaacagcg ccaaggaatt 2370721 cccagccttc gtattttgtg accagacccg caacttcgta tctgcgcact tgctcgtcca 2370781 gtgcgtaaag cagctgctgt cccgtcgtcg caccagcata agcagttctg tggtgctgtg 2370841 tacccccgaa tcggcggaaa tcaagcaggc cttcaggcgt ccggttaaac atgacgccca 2370901 tccggtctaa taagtggatg atcgaaggcg ccgcttcaca catcgccttg accggcggct 2370961 ggttggcaag aaagtctccc ccgtataccg tgtcatcaaa atgttcccac ggagagtcac 2371021 cttccccttt tgtattgacc gctccgttta tgccgccttg cgcacaaact gaatgagaac 2371081 gtttgacagg aacgatggaa aacaatttaa ccgccattcc tgattccgct gctttaattg 2371141 tcgccatgag gccggcaaga cccccgccga ctacgataat gcttgattga ctcatgatag 2371201 cccctctccc tctagtaatc tagtactctt aaacaaatgc aaaaatcgct tttaagccta 2371261 cgtatgacag tgcaacaaaa ataatcagcg taacgtatgt cgaaattctt tgagaacgag 2371321 gcgttaccgt gatgccccat gtaacagcga aagaccataa accgttcgag aagtggaaaa 2371381 ttgttgataa aacaccgaca atgtaaaaac caagcatagc cggagagctc aaaatattcg 2371441 ccatcatgtc gaaattgacc tcagcaccca tttgtgcggc aatgcgggtt tcccacacgt 2371501 gccagctgac gaaaatgagg gtgatgatac cggttacacg ctgcaggacg aatagccagt 2371561 ttctcatgta gctgtattga ccggcgttat ttttcgcagt aaacgctatg tacacaccat 2371621 aaactgcatg ataaattaat ggtaagaaga taataaaaat ttccaaggca tacctgaaag 2371681 gcaggctatc cataaaatga gcagcgctat tgaatgcttc agcgcccctt gcggcaaact 2371741 ggttgacgac taaatgctga ataagaaaga tgccgaccgg tatgacgcca agcaaggaat 2371801 gcaatcttcg aaaataaaac tctctgttcc cagacattac tttaccccct gtttgataag 2371861 tgcgaaatgt gctaaatctc ttcccccact tctttcaatt gtaagcactt tattaagatt 2371921 tattgacaat ttcattttac tcctccctca aaagggcgtc aagaaaacgc gtacataaat 2371981 tataattttc cgaattgatt agttgattga aaaattttat tttatcaata tatatttctt 2372041 gcttaatttt tcataagaat tacaggatca ttctgtaatc ctcccccctg tttgagctat 2372101 aatatacgca ggagagaggg gagacagata tgaagtctaa atttgaagca tctattgaca 2372161 acctaaaaga aattgaaatg aacgcttatg cctacgaact aatacgagag atcgttctcc 2372221 cagatatgct tggccaagat tactcttcca tgatgtattg ggcaggaaaa catctcgccc 2372281 gtaagtttcc tcttgaatca tgggaggaat ttccggcctt ctttgaagaa gcgggctggg 2372341 gaaccctcac caacgtaagc gctaaaaaac aggagcttga atttgaactt gaagggccga 2372401 tcatttccaa ccggcttaag catcagaaag aaccttgctt tcagctggag gctggtttta 2372461 tcgctgaaca aattcaattg atgaatgatc agattgccga atcatatgaa caagtgaaaa 2372521 agagagccga taaagtggtt ctgactgtga aatgggatat gaaagaccca gtgtaatcaa 2372581 aaaggcggtg actgcatagt cccgcctttt tgattgtcat tacacagctg aagggtgttt 2372641 tgaaagctca aatgcatcgt gaagcgactc gactgctttc accatgtcat tttcgcttac 2372701 gactgttgac actttgattt cagatgtgct gaccattttg attaaaatgt ttttttgcgc 2372761 cagtacagca aacatttcag ccgctacacc gggatttgag accatgccgg atccaacaat 2372821 agatacttta gccaatttgc tttctgtctc gattttctca aattccagcg cgtctttata 2372881 ctcttcaagc accgcaacgg tttggtctgc atcttctgtt ttgacagaga aggaaattcc 2372941 agtcttgtcc tcggcctgcg tttggataat gatatccacg tttatgtttc ttttggcaag 2373001 tgttgtaaaa atagtagaca aagttgtcag gccgctagtc agcccgtaaa tggttactct 2373061 tgtgatttga tcttcaaatg caatgcctct gacaattaaa ttctgttcca tggatgattc 2373121 ctcctcaatt aatgttcccg cttcggtttc tgtacttgaa cgcacttcta acggcacttg 2373181 gtaatttttc gcgaactcaa ctgctctcgg atgaagaaca ccggcgccta aattggcaag 2373241 ctcaagcatt tcatcgtatg agatgccctc aagttttctc gctgatttca catagcgcgg 2373301 atcggttgta aacacgcctg gcacgtctgt gtatatgtca catttatcag cttttaaagc 2373361 ggcagccaaa gcaactgctg ttgtatctga accgccccgg cccaatgtcg taatttcaca 2373421 atcctctgtc atgccttgga atcctgcaac aatgacaatt tttccttttt caagctggtc 2373481 tgctaaaacc gaagtgtcga tatctgtaat tctggcgttt ccgtgaatgg cctccgtacg 2373541 gattcccgcc tgccagccag tataagacac agcgtcatag cctttttcct gcaatgccat 2373601 tgaaaggagt gaaatcgtga cctgctcgcc tgtcgccagc agcatatcca tttcgcgttt 2373661 gctcggctgg tcagaaatag cttttgcaag gctgaccaat tcgtcagtgg attttcccat 2373721 tgctgaaacg acgacaacga cttgatggcc tttctgtttt tctgcaattg cgcggtttgc 2373781 cgcattttga attttttcga ctgagccgac ggaagtgcct ccgaattttt gtacaataag 2373841 acccatgtat taccaccctt tacattttgg ttcgtgcggg tgaggagaaa gagcgctttg 2373901 tccacaataa aaaaagcaat gagaggaata ctctcattgc ttatcaatta atcatcataa 2373961 atgattatga acaacgagat agccctccaa gaaaatgatt tcttgacagc cttacattta 2374021 ttcaatgcac ggccagcaaa taataccgat ggggttttat ttgcttcggc gacgctcccc 2374081 tttcagcctt tttcacagaa tccatctttc tccaaaggca tactcttgaa gttcgcacct 2374141 ctatcttcac catataacac gatctaacta tgaaattagt tcacatttta tcagatctta 2374201 tttaaaagga caacattatt tttgcaattt gtcgtaaagg agctgagccg ccgctgcggg 2374261 aacaccggct tttttgatgt cctcaaggct tgcttccttc atttttttaa cggaaccgaa 2374321 atgctttaac agcattttct ttcttttctc tccgataccc gggatgtcgt ccaaaacgga 2374381 ttgaaacgcg ctttttcccc ggatttgcct gtgaaaactg attgcaaaac ggtgcacctc 2374441 gtcctgaatg cgctgcagga ggtaaaattc ctggctgttt cgttccagat acgccacctc 2374501 cagcggatca ccgatcagta aatttgaggt tctgtgtttt tcatctttcg ctaaaccggc 2374561 gatcgggata tccaagccga gttcattttc aatgacatcc cttgctgcgt tgatctgccc 2374621 ttttcctccg tcaatgataa tcagatcggg cagcggcaga ttctcacgaa gcactctcgt 2374681 atagcgtctt ctgacaacct ctctcataga accgtaatca tccggccctg taacagtttt 2374741 gattttatat ttgcggtatt cctttttgta tggtttgcca tcgataaaca caatcatcgc 2374801 ggaaaccggg tttgtcccct gtatatttga gttatcaaac gcttcaattc tgtgcggcgt 2374861 ataaatattt aatgcctcac ctagtttctg cactgccccg attgaacgct cctcgtcccg 2374921 ttcgattaaa gagaattttt ctttcaatgc gattttcgca tttttatggg caagcatgag 2374981 cagttctttt ttcgggcctt ttttcggctg gtgaacgttt gtttccagta gctgctcgat 2375041 catagattga tctatgctgt ccggaactaa aatctccttc ggaaggaagt ggttgttttt 2375101 tgaatagaac tgcccgatga acgtgaggaa ctcttcatct gcttcctgat aaagcgggaa 2375161 catgctgaca tcgcgttcaa tgagctttcc ttggcggatg aaaaagacct gcacgcacat 2375221 ccagccctta tcgtacgcgt acgcgaacac atcacggtcg actagatcgt tcatcgtcat 2375281 tttttgtttt tccatcgttg attcaatatg ggcaatttgg tcacgaagct cttttgctcg 2375341 ttcaaactca agattctcag cagcttcatg cattttctct tcaagctctt ttttgacctc 2375401 attatagccg ccccttaaga aacgtgtaat gctttcaacc agctctctgt tcgtctcttc 2375461 ggaaatatcc tttacacacg gagcaaggca ttggcccaga tgatagtaaa ggcacactct 2375521 gtccgggagc ttggagcatt ttctgagagg atacagacgg tcgagcagtt tttttgtttc 2375581 ccttgctgcc tgtacattcg gatacggccc gaaatagcgc cctttgtctt ttttgacatt 2375641 gcgggtgaca atcagccttg ggtggcgttc atgggtgagt tttatgaaag gataggtttt 2375701 gtcgtctttg agcatgacgt tgtatttcgg atcatgcttt ttgatcagat tcatttctaa 2375761 aataagcgct tcaagattgg aggacgtcac aatatattca aaatcctcga tttccgtcac 2375821 aagcctttgg gttttcgcgt cgtgagaacc ggtgaagtag gagcgcactc tgtttttcag 2375881 cacttttgct ttccctacgt agatcacagt ctgctgccgg tccttcatga gataacaacc 2375941 cggttgatca ggaaggaggg cgagtttttc tttcagttgt ttgttcatat gttacccttc 2376001 cttatgttta atcctttatt tccagtttaa cacgaacgtt tgtttttctc tatggttcac 2376061 aattggcgaa taaaaaaagc gatccctcaa tcggaatcgc tctggcatgt aagcagcgga 2376121 aaattaaaga tgtttgttta caagctcttg aagcgcttct tttggtttga agccgactga 2376181 agtttcaact acttcgccgt cttttaacac aagaagagtc gggatgctca taacgccgta 2376241 ttttccggca gtttcttggt tttcgtctac atcgattttt acgattttca gtttgtctcc 2376301 catttcttga tccaattctt caagaacagg tgcaatcatt ttacaaggtc cgcaccaagg 2376361 agcccagaag tctgccagta cgacgccttc gcttgtttca gctgagaaag attgatcagt 2376421 tgcttttacg atagccatta ttgaattcct ccaatgtgaa atgatgattt ttagtatagc 2376481 atctcccatt cgttcacgct attttaatgc ttacaaatta ttttttcctg atcacagccg 2376541 gtttactcat ttttatatgg ttgaatggga tatgctcttt ttttaaaaca caaatctgat 2376601 aatggccccg atcactacaa ttgccccaat aatcattaaa atggtacgaa gcataagatc 2376661 acatctcctc ttcactgtca tgtactttac catgccctgc cggagctgtt ttaaaacctg 2376721 aaaaagagcg ccggcatgaa gctccggcgc tcttgcgcga ttaagaatca gcacgcagcg 2376781 taagtaagac gactgacatt ggcgggagtt ttactttcag tttgtttttg ctgagcgtgt 2376841 attgtctgaa ggattccggt ttgacatgat gaggatcgtc aaacgtgtta tgcgcattca 2376901 ttttttctgc cgtaagaatg actccggaat ggtccgctgc cttgtgtagg cccctcagct 2376961 cgatttccgc ctctgctttg ttttggtgat cgatgttgca aattgtgata ttgatatcgc 2377021 cttcagcttg tttcgacgct gaaatgctga tttgcggaag cgtttcaccg ttccattcat 2377081 agtcggcaga cattgtctct gtggctaaaa gagaagcgtc ctggtgcacc ttaaacatat 2377141 tgaatacatg gtacgtcggt gtcaaaagca tccgctctcc ctcagtcaaa atcatcgctt 2377201 gaagaacatt tactgtttgg gcgatgttgg ccatttgcac ccggcggcaa tgctgatgga 2377261 aaatgtggaa atgagaagcc gccaccagtg catcacgaat ggtgttttgc tgatataaga 2377321 aaccgggatt cgtgcctggc tcgggatcaa accacgtgcc ccattcatca ataatcagcc 2377381 cgacccgctg ctccggatcg taccggtcca taatcgtgcc gtgtttttga atcaattcat 2377441 cgatgtattt ggcttttttc atcgtaataa accattcatc ttccgtgaat tctgtggctg 2377501 atcctttgcc cttccagaaa tcccccggaa tcgtgtaata atgaagactc aacccgtcca 2377561 tcaggccagc ggcttttttc ataagcacgt ccgtccaatt aaaatcatcc acatttgcgc 2377621 cgcctgcaat tttataaatg tcattcccgc tgtaattgcg gacataagtc tgaaaacgcc 2377681 ggtacagatc tgcgtagtat tcgggatgca tgttgccgcc gcagccccag ttttcattgc 2377741 ccacgccgaa atatttcagc ttccaaggct cttctcttcc attttgcttt ctccagtctg 2377801 acatcggcgt gccttcttca aatgtcatat actcaatcca ctccgacatt tcctgaacgg 2377861 ttccgcttcc gacattgccg caaatatatg gctcgcattc aagcagctcg caaagcatca 2377921 taaattcatg cgttccgaat tcatttgatt caattgtacc gccccagtga gtgttcagca 2377981 ttgtcttacg gtcaccgaca ccgtttgccc aatggtattc gtccgcaaaa cacccgcccg 2378041 gccacctaag gacaggaatg tgcagctgtt tgagcgcctc cagcacgtcc tttcgtatcc 2378101 cgttgatatt ggggatgtct gagtccgttc cgacccagat cccctcataa atccctcttc 2378161 ctaaatgctc agcaaaatga ccgtatatat ttttgttaat ggttcctttt gcgatatctg 2378221 tttgaatcac tgcttgatgt tcagacatgc ctctgatcat tcctttcata cggatatgaa 2378281 aagcaccaca gtcaaatatg tgatctgtcg tttgcctgag gagtcagcat gaatgtaagc 2378341 gcttttaaag taaccatatt atatatgttc gtacatgtca acgacatttt ctattgtttt 2378401 tatatttgta cgtatgtatt tataaatatg aaaaaacccg gacttttaaa gtccgggatt 2378461 tcctttatga gtgtatattc agctgtttga attcctcagt taataacggg acaacttcaa 2378521 ataaatcacc gacgatgccg taatccgcta ttttaaagat atcggcttcg gggtctttat 2378581 tgatggcgac gatcaccttg ctgtttgaca tgccggccaa atgctggatg gcgccggaaa 2378641 tgccgcatgc aatgtacaaa tccggagtaa cgactttccc ggtctgcccg atttggagag 2378701 cataatcgca ataatcagcg tcacatgccc cgcgagaagc cccgactgcg gcccctagca 2378761 cctctgcaag ctcctgcagc ggctgaaatc cttccttgct tttgactcct cggccgcccg 2378821 caacgataat tttcgcttcg gagagatcaa caccgtccgc cgtttttttc acgacctctt 2378881 ggataacagt gcggaggtca gtaagagaaa catcaatgct ttcgatgctc cccgatctgc 2378941 tggtgtcttt ttctgaagct tgaatgttat tggggcgaat tgttgcaaag atcatcggat 2379001 cggttgaaat gacgcgttca aaagctttcc ccgagtaaat cggccgtgtg aacacaacat 2379061 tccctccggt aacgcttaca tctatagcat cagaaattaa gcctgtttgc agacgggcag 2379121 caagcttcgg tgaaagatcc ttgcccattg ccgtatgccc gaagatgact gaatcaggat 2379181 tttcttgctc gataacacct ctcatgacct ggctgtaccc gtctgccgtg tatgttttca 2379241 gcttcgggtc ctcagcggta agaactttat ctgctccgta atgaataagc tcttgtgcaa 2379301 tgctttgtac attttcaccg atgagaacac cgatgacttc cccatctcct gaaatggttc 2379361 ttcctgcagc tattgcttca aaggtgacat ttcgcaattc cccatcgcgt atttctccaa 2379421 gcacgatcac tttttttccc attctaacat ccccctgttt ctttgaatgt ccaagtttta 2379481 aatgacttta gcttcgctgc ggagcaatga aacaagctct tttgcctgtt cagcaggctc 2379541 accttggaga agcttcccgg cttctttttt cggcggcaga aaacgttcaa tggttttcag 2379601 ctttggttca gcatcctctt cgtccagatc aagatcatca agttcaagct cttcaagcgg 2379661 ctttttctta gccttcataa ttcccggaag cgatggatag cgcggctcgt ttaagccctg 2379721 ctgagctgtg acaagcaatg ggagcgtcgt tttgattttt tcaacatccc cttcgacgtc 2379781 cctttctgct tctgcatcag tgccgttgat ttcgagtttg gtgatcgtag tgatacacgg 2379841 aatgtccagt agctcggcaa gccgaggcgc cacttgtcct gatcctccgt caatggcaac 2379901 atttccgccg agaatcaaat caaactcctg atccttcata tagtggtata aaacttgaga 2379961 aatggaatat tggtcgggtt catcaagatc atcttctatg ttgattaaaa cagcttggtc 2380021 acaacccatg gcaagcgccg tacgcaattc tttctccgct tcttcaccgc cgaccgtgac 2380081 agcggtgatc gtgccgccat gcttttcctt cagctggatg gcttcttcta tcgcgtactc 2380141 atcatatgga ttaatgatcc attccgctcc gtcatcctga atctttcctg tttcaatgac 2380201 gattttttct tctgtgtcaa acgtccgttt catcagtaca aatagattca tgatcatatc 2380261 cccttttatt cgcctttgaa ctgaggcttt cttttttcga gaaatgcctg gatgccttcc 2380321 ttggcgtcct ctgactcaaa tgcttcccca aatcgctttg cttcaagctt taagctgcct 2380381 tcataggaat acaccttgtt ggaataaaga agttcaagca aagatgccag cgtttgcggg 2380441 cttttctctg caaacttagc ggcaagtgct tttgcttttt caatcacttc tgcctcatct 2380501 ttcgctccaa ttgagacaag tccgagatca agcgcttctt ttccggatat cggttctcct 2380561 gatccgatga gctccagtgc tttggctgta ccgacatatc tcggaaggcg ctgtgtcccc 2380621 gcaaaacctg gaatgatacc gagattaagc tccgggagcc ccagcttagc atcttctgcc 2380681 gcgattctga tgtgacaggc cattgcaagc tccagcccgc ctccgagagc agcgccgtga 2380741 atcgctgcga taatcggttt tggaaaactt tcgattctct ccattaactg ctggccgcgc 2380801 tcagcgagca atgaggaatc ctcattgcct ttaagcgatg taaattcttt aatatcagcg 2380861 ccggctgaga aaaatcttcc ctcgccgtga atgataatgc ttcgtacgcc tgcatctgtc 2380921 tcacattgat caagacagga agacagctct tctaatatcc ggcttgaaag cgcgtttgcc 2380981 ggcggattgt gaatcgtcaa gactgccaca aattgatcaa ccgcaagtga aattgcattc 2381041 ataggacaga actcctttac ttattgtgaa ttccggatac caataattct aaaacgctgt 2381101 ttgaaagcgc aacgagatcg tacttttggt cattcatcac ccaagttgtc acagtttcgt 2381161 caatcgttcc aaaaatcatc tgccgggcga ggcggacatc gaggccttct tttatttcgc 2381221 ctgattgtat accttccgtc aaaatgccat ccaaaatatt taagtagcct tttaatattt 2381281 cgttgatttt ttggcgcagc tccaagttgg attggcggag ctcaagctgc gtgacaatgg 2381341 cgagattatg gtcacccgct aaaagggaaa aatgctttga aatcacaagc gccaatttct 2381401 ctttcgctgt tgctttttct ttaatgtcct cttccatccg ctcaataaat tgacccattt 2381461 tttctttgaa aagagaaatt aaaatatctt ctttgttttt aaaatagaga tagatggtgc 2381521 cgtccgctac cccggcttgt ttggcaattt tggatacctg tgactggtgg tagccgtttt 2381581 ctgcaatgac ttctactgct gcatcaataa tctgcatata ctttggccgt ttttgcttca 2381641 atgttcatcg ttccttccta tagaaatgaa tgactattca ttcataattt catgataaga 2381701 aggattttca ggtttgtcaa gtttattcat aggcgttctc tttttttatt tgatatgatg 2381761 attttcggtt tcttcttcaa gtaaacgcct tcttaaaatt tttcccaccg ccgttttcgg 2381821 cagctccttt ctgaactcat aggctttggg caccttatag ggagctagac gtgatctcgc 2381881 aaaagcgtcc agttcttctg tatcggcttt tgcgcctttc tttaatacga caaatgcttt 2381941 tactgtttct cccctgtagg aatcgggaac gcctgcgaca acaatttcct ggatggcttc 2382001 atgttcataa agcgcttctt ctacctcacg cgggtaaata ttgtaaccgc cggcaatgat 2382061 gatatccttc ttcctgtcag caatatagaa aaagccttct tcatccatat agcccatgtc 2382121 cccggtgaac agccagccat ctctcagcac tgcggcggtt tcctctggtt tattccagta 2382181 tcctttcatg acttgcggac cttttacaat gatttctcca tgctcatacg gagcggcaag 2382241 ctcacccgtc tcttcagaat agatcgcagc gtccgtactc ggccaaggac agccgatact 2382301 gcccggcttg ttttttcccc agataaagtt ggcgtgcgtc actggggatg cctcagacaa 2382361 accatagcct tccacaagct ttccaccagt caccttttca aatttctgct ttacctccac 2382421 ggggagcgcg gctgatccgc taagacagct tttaatggat gacagatcat aatgctgcaa 2382481 ttcagggtga tgcaaaaggc caatgtaaat tgtcggtgcg ccaggaaaga gcgtcggttt 2382541 gtgtttgtcg atgattttaa gtgtttcgag cggatcaaac ttaggaagaa gaatcatttc 2382601 gaagcctagt ttaatcgaat agttcatgac tgccgtcagt ccgtagacat gaaaaaatgg 2382661 aacgatgccc agcacttttt cagcgccttc tttcacgtca tacatccaag cggcgcacat 2382721 ttcagtattt gccaaaatat tttggtgcgt gagcatgacc ccttttggag ctccggttgt 2382781 tcctccggta tactggagga cagcgatatc atgctcagga tcgatcttcg ggattgtcag 2382841 gagttcagtt ttttcctgct tcatacagga agcgaacgtg tgaatgttag ctgttttgtc 2382901 aaagtcgata tgcacttttt gtttttgcgt cagcgggtaa agaatatttt tcggaaaagg 2382961 caaatagtct tttacactgg ttatcaaaat ctggtcgact attgataacg ttttcatttt 2383021 tattgccttc gggaaaagca aatctaaggt gatgattaca cttacctgag catctctaag 2383081 ctggtattca agctcatgct cggtataaag cggattcgtc tgcaccacga tgccaccggc 2383141 aaacaagacg ccataataag aaatcactgt ttgcgggcaa ttgggcagca taacagccac 2383201 tctgtctcct ttttgcaggc cattgcactg caaaaaagct gcaagtttaa gagcatccgt 2383261 cagaatgtca tgaaaggtga gtttttttcc ataaaacgat attgcggttt tatcagggaa 2383321 tcgtgcggcg gagtctgtca ggatggattg cagggtttta ttcggcaacg gaagctcatg 2383381 cgggatatcg ttgggatact cggcaagcca cggcttttga gactgcataa aacctcccct 2383441 ttcgatttta gagatccacc ttatcattat agcagatgga cggcaaaaaa aagaaaaaga 2383501 aaggtaaatc tttctttttc tcataatatg aacagatata taagaccaat taacaaaaag 2383561 attcccgctg cggcgagcag tattttcgca agcttttcca tctattctcc gtccccttat 2383621 attccggctg ccaccacaaa agaaagcccg acagaaatga caaatgaaat aaagccgaca 2383681 gcccggttat cattttcgat ttcctgatca attttaaacc gcggagtcaa aaactcaaaa 2383741 ataaagtagc tgatcagaag cataacaaac ccgtaaacgc cccagccgat catttgcagc 2383801 agcgaattat gctgggagat ggaatgctga aatacgtttg cgattcccaa aatttttccg 2383861 ccggtcgcca ttgccaccgc aagatttcct ttttgaatct cttcccagtt tttataagcc 2383921 gtcaccagct caaacacagt caaaaagagg acgaggcaga gaaccgcgac actgtaatat 2383981 gccgcgattt ccacaagctc gttttcccaa aaatcactca tggccatact cccttttatt 2384041 ttagttcaac aaccgtaacg cctgatcctc cctcacctgc ttcaccgaaa cgggaacttt 2384101 tgacgctgcg gtggtttttc agaagatcct gtacgccttt tcttaaagcg ccggttcctt 2384161 ttccgtggat gattgacact cttggatatc cggctaacac cgcatcatcc aagtattttt 2384221 caacccggct gagggcattt tcatagcgtt cgccgcgaag atcaagttca agcgatacgt 2384281 gatagtcctt tcctttgacc gctgtaatca ttttttcttt ttttggctcc ggagctgatt 2384341 tgataaactc cagatctttt tcttttactt tcatctttaa aataccgatt tgaacgttcc 2384401 attcattgcc gcctgttttt tcgagcaatg ttcctttttg cccgaaagtg aggactttca 2384461 cctcgtcgcc aggcttaaag tcgcgttttt gcgttttcgg cttttccggt ttcttggact 2384521 tttcaaaagc aggcatagcg ccttctaacc gtttcttcgc gttaatcagc tcgtgatcct 2384581 tgaaggattt gtgttcttct tttatggtgc gcaattcatg aataatgtcc tcggcttctt 2384641 tcattgccgc ttttactttt tcagcagcct gctgttctgc ctcttcaagc attttgtctt 2384701 ttttgctgtt aagctcgatg atttgctgct gcagctcttt atgcagtttt tccgcttctt 2384761 ttctgattga ttctgtctca gaaagctctt cttccgcacg ttttttgctt tgttccagcg 2384821 acgcaatcat cgtatcgact tcgttatgct cggccgtcat ttctgacttc gcctgcccga 2384881 tgatatggtc cgggagcccg aggcgttttg aaatttcgaa agcattgctt cgacccggca 2384941 caccaattaa aagtttatag gtcggtgaca gcgtttcgat gtcaaattca acgctggcat 2385001 tcatgacgcc ttctctgtta tagccgtacg ccttcaattc cggataatgc gtcgtagcta 2385061 acactcgtgc attggtgcga tgcacgtcat ccaagatgct catggcgagg gccgccccct 2385121 cctgcggatc tgtccctgca ccaagttcat cgaaaagcac aaggctgttt tcattgacct 2385181 gttctaaaat gccgacaata ttcaccatat gggatgagaa cgtacttaaa ctttgctcaa 2385241 tcgactgttc atcaccgata tcagcgaata cgtgctcaaa tactgccgct tctgaccctt 2385301 catctgccgg gatatgaaga cctgactgcg ccattaaggt tagcaggcct aacgttttaa 2385361 gggtgactgt tttccccccg gtgtttggcc ctgtgatgac aatggttgaa aaatcgcggc 2385421 caagctcgat gtcattggca acaacctgat caggcggaag caatggatgg cgggcttttt 2385481 tcaaacggat aaagccggtg tcgttcataa tcggttttgt cgctttaacc gcttttgcat 2385541 atctagcttt tgcaaaaata aagtcaagcg tctgcagcac ttgcaaatct agaaatagct 2385601 cctctgtata ctctgccgtt ttctctgtca gcacacgcaa aatccgttca atttcttgct 2385661 tttctttcac tttcgcctgc tgaagggaat tgttcatatc tacaatcgcc tgcggttcaa 2385721 tgaatagtgt cgcaccagag gatgaggtgt cgtgcacaat tcctccatag ctggatctgt 2385781 actcctgttt gaccgggatc acaaagcggt cattccgaat cgtaacaatc gtatcagaca 2385841 gcattttcga tgcggaagag gaacgcagca tcgactctaa ccggtctctg actcttgatt 2385901 cgagtgttct gagctgtgtg cggattcctc ttaatgtttc cgatgcatga tcaagcactt 2385961 ctccgtgatc atcaatgcag gaattaatgt cccgctctaa atcggacagc gtgataagct 2386021 gttcagcatg ctgatggatc agcggaatgt cgacaccgtc ttcagccatt tgcgtgataa 2386081 aatgtttcat ttgtttaact gcataaagca ggcctgagat ttcagtgaat tcagaaggac 2386141 tgagaacgct gccgatttcc gcccgtctta acgctcctct gatatctaca aggccgccaa 2386201 atggcgcttg gcctctcagc cggataatgt cagaagcttc gtctacttca tccagctgtt 2386261 ttttgatttc gtctatagaa gcagaaggct taagctcgag aagcatttct tttccgagcg 2386321 atgaagcggc atgcccaata acctgttctt tcactttatg aaattcaaga gctgataata 2386381 ctttttgctg cacgattgtg tgagcctcct tacttaatcg ttgcgcttca gaaatgcctc 2386441 tacgtcttta agcgaccggg cattcagaac gtttttcgtt tccgtccatc ctttgcgcgc 2386501 ggcagtaacg ccagttttca tatcgtctaa catctcaata ttatgggcat cagtattaat 2386561 caccaatgta accccttgtt cgtttgcttt cattaaatgc tctgtgcgca gatcaaggcg 2386621 cgcagggttg gcattgagtt caagcgccgt atttgttttc ctcgcaagct caatcagctg 2386681 atcaatatcg atttcgtaac cggcccgtct gccgataagg cgcccggtcg ggtgtgcgat 2386741 aatgtcaaca tgcttgtttg tcagtgccgt ctcaagccgt ttcataatca cgtgttccgg 2386801 ctgattaaaa ctggaatgaa tcgatgcaat aacgatatcc atttccgcaa gcacatcgtc 2386861 atcataatcg agcgtaccgt caggcaggat atccatctca acgcctttca aaatacggaa 2386921 gttttcaaac tctgcattca gcgcgtcaat ttcttttgcc tgctgcttaa gtctttctgc 2386981 agtaagcccg ttggcgacct ttaaatattg tgagtgatcg gtgatcgcca tgtattgata 2387041 gccttttttg atgcaggctt cagccatctc tctgatcgaa aatgcgccat cgctccacgt 2387101 tgagtgcatg tggagatcac ctttgatttg cccgagctct atcagttcaa tgctgtcgct 2387161 gtaggtttcc acttcctgtc cgctttcacg aatttccggc ggaatcagcg gcaggccgaa 2387221 gtgcgcataa aattcacgtt cactcggaaa tgttttgatc tctccggttt caactgtctc 2387281 aacgccgtat tcactgatcc gctcgccgcg ttctttggcg atttggcgca tcttaatatt 2387341 gtgatccttt gatcccgtaa aatgatggag tgttgtcgga aactgctctt ccgtcacaag 2387401 acggaaatcg acgcttgttt catattcaaa ggaaaggatg acggacacct tcgtatctcc 2387461 gcttgcgatc acgcttttga tgtttggcag ctcaagaagc tgctctctta cttcagccgg 2387521 atgatctgta gcaatgatat aatccagatc cttcaccgtt tcccgcgctc tgcggagact 2387581 tccggcacga gaaaatttga tgatatgcgt aaattgagaa agatgctcct caatttcccg 2387641 cgcgatccgg agggcgtagc cgatcgggaa ccgttcaggc tgttttccgg cttccccgag 2387701 cgcctgtaat attttttctt ccgatttttt gccgaagccc gcaagaccct ggaccttttg 2387761 ctgctcacag gcttccttca gagattctgc atcgtgtacg ccgagctctt tatacagctt 2387821 tgcgattttt ttgccgccga gccccggcag cttcaataaa ggcacgagtc cttccggcac 2387881 ttctttctga agcgattcga gcgtgcttga ctttccttca tctatatact ctttaatgac 2387941 gctgtacgtt ccttttccaa tgccggacag cgacatcata tcgtccattt ctgataagct 2388001 tcggtcgtcc tgttccagag ctgccgccgc ttttcggaag gcggatactt taaacgggtt 2388061 gtcccctttg agttccatat agactgcaat ggtttcaagc agccggataa tatctttttt 2388121 atgcatatca taacccccag acgttcacat atgtttccat catacttgaa aaaaacttct 2388181 ccggacaaga gaagtttttt tatgccccgt actgtgtcca cagctcttgt aaaagccctg 2388241 acaagtacgg tgtatggtta atgatcacat ttgcgagaga cgattgcccc atcatttgct 2388301 gcaacgcgtc taccggcaga acggatgcga catacagcag cacaaatgta aataaataga 2388361 cttctagaaa accgagaacg gctcccagca tctggttgat ttgtttaatc accggaatgc 2388421 cggctacaat actcaggaac gagccgatga ttctcagtaa gattttagca atgataaata 2388481 aaacgataaa cgcaatcgca ttatagtacg ctgcttccaa attccccgta aaaaaagaaa 2388541 gagccggctg tcccgctgaa aaatcgggtg cgggaatcca atgtaaatgc ggtgccacgt 2388601 ttttatagaa taaagccgca aaggcaattg ataaaataaa gctcgtcaag cggataaact 2388661 gcaggataaa accgcgtttt aaccccagta aagtccccat caggagcaag attaagatga 2388721 tgatatctag catagttgtt caatcctttt ctttaagctg acgctccagt ttttcacatt 2388781 tctcttgtaa tttgacataa tcgtgcacca catttaccgc tgtcagcact gcaagtttat 2388841 ttatatcaag gtatggattt ttttcattga tttctctcat tttatcatca acaattccgg 2388901 cgacatacct catatgggct ctgctttctt caccgacaat cgtgaagtgc tggccgtaaa 2388961 tgtcaacggt tgtttttgtt tttttgccgt cagacaacgt ttctcctcca ttccgcgaga 2389021 atcctagttc ttatcataac acgtttatta aatgaatgga aagacgagcc tcccgctgtt 2389081 atgatacact ggtatataca gcgaaaagtg taaaaaaagg agattattac gtgtcccatt 2389141 cagtgataaa agtatcgttg tctgctattg accaaatgaa aatgacgtac agcggttcac 2389201 ttacagcctc tgttccgcag ggagccgttt ttcaggcaaa accgcccggc tgtaccatta 2389261 cagcatatca atcaggtaag gtcttgtttc aaggaaaaaa cgctgcggca gaatccgcgc 2389321 gctggggaac agcagagcct caggaaaaga agaaaacggc caaaaagccg gctgatcccc 2389381 gctatgcccc tccggcagat atcgccggaa tgtctgttat cggttctgac gaagtcggaa 2389441 ccggagatta ctttggccca atgacggttg tatgcgcgta cgtcgacaaa accatgcttc 2389501 ctttaatgaa ggaactcggt gttaaggatt ctaaagattt aaaagatccg caaatcatcg 2389561 agattgcccg aaacctgatt aaaaccattc cgtacagcct gctggtgtta aagaatgaaa 2389621 agtataacag catgcaggaa aaaggcatga gccaagggaa aatgaaagct ttgctgcaca 2389681 atcaggcgat cacacattta ttaagaaaat tggatggagt aaagcctgaa gccattttga 2389741 ttgaccaatt cgctgagcca ggcgtctact tcaatcattt aaagggcaga gacattgtga 2389801 aggagcggac ctattttagc acaaaagctg aaggtattca cctggctgtc gccgctgctt 2389861 caatcattgc aagatattca tttttaatgg aaatggataa actatcacgc gcggcaggaa 2389921 tgacgcttcc aaaaggggcc ggtccgcacg tcgatgaagc ggccgccaag ctgatcctca 2389981 aaaaaggggc atctgcactc agaaccttta caaaactcca tttcgccaat acgcaaaaag 2390041 cgcagcgcct tgctgataaa aaacgttcat agaaaaaagc ttgcagattt ctctgcaagc 2390101 ttttttatca gcctcttaaa acagcttgat atgtgtcttc taacgctttc agcactttgc 2390161 tgtgcgcctt tgtcacttct tcttcagtca gtgtttgttc aggattgaca tactggagtg 2390221 agaaagcgac tgacttcttg ccttcctcca tatgctctcc ttcgtatacg tcaaatacgg 2390281 ttacctcttt cagaagcttg cccccggcct ctttaatgac gctctcgagc tgtccgcttg 2390341 tgacggtttt atctgttaca agagcgatat cacgtgtcac agacggatat tttggaatcg 2390401 ccgtgtaaac aagcggtgct gtttctgctg cgagcaacgc atgaagatcg agctcaaata 2390461 cgtatgtttc ctttatatcc agttcttttt ccaatgaagg atggacttgg ccgatgaagc 2390521 cgatcagaga accattcaat aaaatgttcg ctgttctgcc cggatgcagc tgtttgcgtt 2390581 cagactgtac aaattcaatg ctgtctagga cgttgagttt gtctaacagc ccttccacaa 2390641 ttcctttgac aacaaagaaa tcaactggtt tcttttcacc ctgccatagc tgcttgcgcc 2390701 ataatccggt aacagctcct gctacgcgtt ctgtttcaac aggttttgtg tcctcttcct 2390761 tcgttaggaa aacggagcca acttcgtaca gtgcaactga gtcagtctgc ctcgcaagat 2390821 tgtaagaaac agaatcaagc agatttggaa caagactgtg tctgagaatg cttctttctt 2390881 cactcattgg aagcgcaagc acagtattca gtgatttttc aatcgcaaac gctgtcgctt 2390941 tcttctcgtt tgtcagtgag taagtgatgg cttgtgataa gcctgcgcct tcaaggaagc 2391001 gtctgacttt acggcgtttt gcctgatatg gcgttaatcc gcctgtagtt cccgctgtct 2391061 caggaagcgt agacggaatg ttatcgtagc cgtacagtct tgccgcttct tcgattaaat 2391121 cctcttctat tgtaatgtca ccgcgccgtg atgggacagt cacaacgaga agatcatccg 2391181 cttcaccgac cgtaaaaccg agacgtttat aaatgctgat cagttcttct ttactgatcg 2391241 tcaggcctag aacgctgctc actttgtcag cagatacgtg aatgttattt gcttcgattg 2391301 tcaggtgatc ttcctcaacc gttccagcaa gcacctcacc gccggcatac agatggatca 2391361 gctgcgcagc ccgttctgct gcaagacgta cgcgtgccgg atcaattcct ttttcaaatc 2391421 ttacgcttga ttcacttctc aaaccaaggt ctttggaagc cttgcgaacc ttctgcccgt 2391481 tgaaatacgc agcctcaagc aaaatggttt tcgtatcttc ctgaacctct gactctgctc 2391541 ctcccatgac accggcaacg gcctgcgctt tcgttccgtt tgtaatgaca aggtgatcgg 2391601 cagacagctt acgttcttga tcatcaagtg ttacgatcat ttcattctca gctgcttttc 2391661 ttactacgac ttccttagag ccaaatctgt cataatcaaa cgcatgaagc ggctgtccgt 2391721 attccaacag gacaaaattt gtgatgtcaa cgacgttgtt gtgcggacga atgcctgcat 2391781 tcatcagctt tgtctgcatc caaagcggtg acggagcaat cgtgacattt ttaatgattt 2391841 ttgcagtgta cagcgggttc gcttcttgat cttcaatttt gactgaaatg taatcagacg 2391901 cttgttctga agcagccggg taatccgttt gcggaagctt tacctcagtg tctaaaatcg 2391961 ccgcaacctc gtaagcaaca ccaagcatgt tcatggcatc cgcgcggttt ggcgttaaac 2392021 ccagctcaag aatcgcatcg tcaagctgta aagccgctaa ggcatcgctt cctgtttcag 2392081 cgtcattcgg gaatacgaaa atgccttctg catactcctt cgccacaagt ttgctttcga 2392141 taccaagctc ctgtaaggaa cagatcatgc cgtttgattc ttcaccgcga agcttggctt 2392201 ttttgatttt gaaattgccc ggcagcaccg ctccgactgt tgcaactgcg actttttgtc 2392261 ccttatccac attcggcgcg ccgcaaatga tttgtacagg ggcttcagct ccgatatcca 2392321 caaggcactt attcagctta tcagcattcg ggtgctgctc gcgctccagc acatggccga 2392381 tgacaacgcc tttgatgcct tctcctttgt attcaattcc ttcaacctca ataccggctc 2392441 ttgtaatttt ttcagcaaga acagccgggt ccatgccttt taaatcaaca taatcctcta 2392501 accatttata agaaacaaac atccttgcat cctcctctta cgcctgttta aactgcgaaa 2392561 taaatctgac atcgtttgta tagaagtggc ggatatcatc aatgccatat ttcagcatcg 2392621 cgatgcgctc aacacccatt ccgaatgcga agccctgata ttccttcgga tcaaagccag 2392681 ccattttaag cacgttcggg tgaaccattc cggcaccgag gatttcaatc cagcctgttc 2392741 ctttacatac tgagcagccg ttcccaccgc atttaaagca tgtcacatcc acttctactg 2392801 aaggctcagt aaacgggaag aagcttgggc ggagtctgat ttcacggtct tgcccgaaca 2392861 tttttttcgc aacaagttca agcgttcctt ttaaatcact catgctgatg tttttgtcaa 2392921 cgacaagccc ttcaatttgc ataaattggt gagagtgcgt cgcatcatcg ttatcacggc 2392981 gatatacttt acccgggcaa atgattttaa cgggaccttt gccttcatgc ttttccatcg 2393041 tacgtgtttg gacaggagaa gtttgcgttc tcatcaaagt ttcctctgtg atgtaaaagc 2393101 tgtcctgcat atcgcgcgct gggtgttctt tcggaagatt gagcgattcg aagttgtagt 2393161 aatccgtttc aacctctggc ccttcctcga ctgtgtagcc cataccgata aataaatctt 2393221 caatttcttc aatgacaaca gtgagcggat ggcggccgcc gactgcaaca gggttccccg 2393281 gcagcgtgac gtcaattgtc tgtcctgcaa gcttctgttt catttcctct tcttcaagct 2393341 tctcgttttt gtcagcaatc gcattggcaa tacgctccct tacttcgttc gcgagcgccc 2393401 ccatttttgg acgttcctca gcagaaagct tgcccattcc gcgcagcact tctgtaatcg 2393461 gccctttttt tccgagatat tgcacccgaa tatcattgac aaccttcaat gagcttgccg 2393521 cttctacttg ttctaaagct tcttgttcca gctgttttag cttttcttcc attttgcatc 2393581 ctccttttat gtaaacaaac cgtcatatgt ctttggaaaa taaaaaaaac ccgtcccttg 2393641 tacaagggac gagttgtggc cgcggtacca cccttatttc agacagactg atgctgtcgt 2393701 cagcttcatt gacataacgg aatcagattc cggttcacct ttacgcgcag tgtacgcggt 2393761 cccggcgaca actcaagagg tgaagccaat ttccggctgc gttaaaaatg ctctcagtca 2393821 gcggcatttt ctccctggaa agcagttgat cagaaattga ggtcctctgt cacggttttt 2393881 gaaatattat gttctattat agagaaatcc aacgcttggc gcaacactat cctcgcaagt 2393941 gatacacgag gatggcagcc gcaaccgcaa cgtttagtga ttcagcctgt ccgtaaagcg 2394001 gcacgtacag gttcaaatcc gttttttcca gcaatgcagc atctacccct gcaccttcat 2394061 ttcctacaat gagcgcaaag gattcagact gaggaatctc ctggtaaggc gctccgtttt 2394121 gcagcgccgt gccgtatact tttacgccct ctgccttcaa ttcgtccaca tatgaaggca 2394181 ggtttcttct cacaacagga atatggaagt gagatccttg agcagatcgc agtgtttttc 2394241 cgttaaaggc gtccgccgtg ccgtcaccga gtacaaccgc atccaaaccg gccgcatcag 2394301 ccgttcgaat cattgtgcca aggtttcccg gatcttgaac agcgtcaatc agcagcacct 2394361 tgcgtgccgt tgccagcttt tcttcaggca tatggcacac agcggcaatc tgctgcggcg 2394421 tttcggtttc agtcacagct gaaaacgcat cttcactcag catatagcac tggataccag 2394481 tctcaagatc tgaaggaatc ctcgtttcat cctttacaag gatttctttc acaatgcccg 2394541 ggcttttcaa cgcctcttca acgaggtgtt ctccctctat cagaaatgta tttgtttttg 2394601 ttcgttcttt ttttgtgtga agctttttcc aatccttcac tttttggttt tttgccgatt 2394661 ctatttgttt cactgtctat gtggcgctcc tttttttaac atgatgttat tatatcgcaa 2394721 gaacagcaca taataaacca ggtgcagggt tagaatatac gtattacatt ttagaaaaag 2394781 gagcgtttta catggatctt aatttacgtc atgccgtcat tgccaatgtc accggcaata 2394841 atcaggagca gcttgagcat acaatcgtag atgcgattca aagcggtgaa gaaaaaatgc 2394901 ttccagggct cggcgtttta ttcgaagtca tttggcagca cgcatccgaa agtgagaaaa 2394961 acgaaatgct gaaaacgctt gaaggcggat taaaacccgc cgaataagac atgaaaccgg 2395021 gtgacagcgc ccggtttttt tcttatataa taaaaacatg atgaggggga acgccatgtt 2395081 tttacagccg ttattagcga aaaaaattat tgctgaagtt aaaaaaatgt acgaacgtga 2395141 agtcattatt gtaaacacgg acggtcttat tatggcaggc acaaacgatg agcgtgtcgg 2395201 acaatttcat gagggagcgc ttatctgcgc aaaagaaaga cgcagcgtga ttattacaaa 2395261 agaagatgaa acaaggttaa aaggagtgaa agcaggcata aacctccctg tattttttga 2395321 ccatgatgtg attgccgtct tcgggctgac aggtgagcct gcagagattc agccattcgg 2395381 agaactgctt cgaaaaatga cagaactgtt cattaaggaa tcgcggcact tagagcaatc 2395441 ccagtggcgt gagagaatgc tggagtcctt tatgatcgat tggctgcaat taaaggagtg 2395501 gtctcccagt tttcttgaga aagctcagct tcttggtgtt gacctttctt cccggcgcca 2395561 aatgattctt attcaggggt atgagtggtc acctcatgat attgaacaaa tggcacgcag 2395621 ctggaaatcc tcgtaccctg cggatttgtt catcaggtgg ggaaatgaac ggattttgat 2395681 taatcatgaa gtgccgcagc atgaacaaag ggatcggctt ttgcggaaaa tccttcacat 2395741 ttgttcgttt gccaataccg caagcagcca atatacagca gctggcgccg gaagggctgt 2395801 cgcaagctcc agcctgacag attcatacga gcaagcggaa aaagcgctgg ctgtcagcct 2395861 taagcgaaaa acgcccatat ttgaagagga tctgaagctt gatatgtgtc tgacggagat 2395921 cagcccggga acccgaaacg aatttccgca aagagtatta ggaaaggcgc tagagcatca 2395981 ggaacttatg aatacgatac ggactttctt tcatcacgat ttgtctttga aacaaaccgc 2396041 tgaagacatg catatacaca tcaatacatt gcgttatcgt ctggctaagg ctgaacagct 2396101 gacgggatta cgttttgacc gtaccgagga cgtcgtcacg atgtacgtcg cactctattt 2396161 tttagatcaa gatacaaaat agagagagtt tcagtttcat tttttgtatg tttctccatg 2396221 gaaggctttg ctttttttct tttacaatag attgaaagcg ttttttgaca gggggatggg 2396281 tgaaatgatc accaaggatg taaaggagca gctgattcag gtctccggac cagaaaactt 2396341 tgatgactcg aatgccggcc gtctcgtcta ttcatatgat gcgacgcctc agtatcagtc 2396401 tatgcctgat gccgtgattg ctccgaggaa tactgatgaa atatcacgca ttttaacaat 2396461 ttgcagcgaa catcgagtgc cgatcgttcc aagaggatca gggacaaacc tgtgcggcgg 2396521 cacgtgcccg actgaaggcg gacttgtgct tctctttaag cacatgaacc agattcttga 2396581 aattgatgaa gaaaatttaa ctgccacagt tcagccgggc gtcattacgt tggatatgat 2396641 ccgggcagtt gaaagcaaag gtttatttta tccgcctgac ccgagttcta tgaaaatatc 2396701 aactatcggg ggcaacatca atgaaaattc cggcgggcta cgcggattaa aatacggtgt 2396761 cacccgcgac tatgttattg gactggaggt tgttctcgca aatggtgaca tcatccgcac 2396821 cggcggaaaa ctcgcaaagg atgtggccgg atacgatctc acacgtcttt ttgtcggctc 2396881 agaaggaaca ctcggcattg tgacagaggc aatcgtcaaa ctcgttccaa agccggaaac 2396941 aaagaagacg ctgcttgccc tttatgaaaa catcgatgcc gctgctcaaa cggtatcgga 2397001 cattattgcc gcaaaaatta tacccgctac gcttgaattt ctcgatcagc ctacactatt 2397061 ggtgattgag gattatgcca aaatcggact tccgacaagc gcaaaagcag ttctgttaat 2397121 tgaacaagac gggccatttg aaactgttga acgggatatg gaaaagattg aggcgatctg 2397181 caaaaaaggc gacgccgtat ccgttcagac cgcacaaaca gaggaggaag cgtttgccct 2397241 gactgaagcc cggcgttctg cactttctgc cctagcccgc ctcaaaccga cgacgatttt 2397301 agaggatgcg accgttcctc gctcagaaat cgccaatatg gttaaagcga ttaatgatat 2397361 tgctgctaaa tatgatattt ccatctgcac ctttggtcat gcgggagacg ggaaccttca 2397421 cccgacatgc acgacagaca taagaaataa ggatgaaatg gaacgtgtcg aacaggcttt 2397481 tgccgagatt tttgagaaag cgattgaact tggcgggacg ataaccggag agcacggagt 2397541 cggggaaatg aaagcgcctt acttggaaat gaagctgaaa aaagaaggca ttgatgcgat 2397601 gaaagcgttg aaagcggcat ttgacccccg gaacatatta aatcccggca aaatgtttgc 2397661 gaaagatgcc agaaaacgtg tggtggcgga aagatgacaa cagaaaaaga aatgaaacag 2397721 atccaaaatg aatttaaaga gcgtatggat gaaggagagt tattaaattg tatgcgctgc 2397781 ggcttctgtc ttccttcctg tccgacctat atcgaatcgg gatttcagga aacacactct 2397841 ccgcgtgggc gcatcgcctt aatgaaagcc gtagccgacg gtatgattga accggatgaa 2397901 gatgtcgaac ggtcgctgtc actttgcctc ggctgccgcg cctgtgagcc tgtatgcccg 2397961 tctggcgtga aatacgggca gctgcttgag gaagccagag atattatcca ccaaaataaa 2398021 aaacactctc ttggtgaacg tgtcatgcga aagacggctt ttcacgagct gtttccgcat 2398081 caaaaccgca tgcgctcagc tgtaagcctt atcggtttgt atcagcgttc aggactgcaa 2398141 accgctgtgc gaaaatcagg catgcttcgg gtcctgcctg agcatttgcg gacgatggaa 2398201 gctgttcttc ctgatgttcc aaaaagcaaa gacatgaaac atcggccgcg tttcctgcct 2398261 tccattggcc ccatgaaaaa acgggtcgcc tttttttcgg gctgcttaat ggatacaatg 2398321 tttttaccga ccaataacgc cacattgaag cttttacagc tggcaggctg cgacattgtc 2398381 attccgcctg aacaggcttg ctgcggggcg cttcatggac acagcggtga aaaaaacaca 2398441 gggaaagagc tcgcgaaaca aaatatcgct gctttcgaag cattagacgt ggatgcagtc 2398501 attacaaacg caggaggatg cggagccttt ctcactgaat atgatcattt gctgaaggat 2398561 gaccctgagt ggtcggaacg ggctgccgct tttgttcaaa agctgaagga tttttcttct 2398621 gttttggttg aactcgattt ccatcaaatg gatctagcac tcgagacgcc tcaggtcgtt 2398681 acctaccaag attcatgtca tctaagaaat gtgatgcata cgtcacttga gccccgccag 2398741 cttcttaaaa gcatcaaagg ggcggaattc aaagaaatgg agaaagcaga cagctgctgc 2398801 gggtcagcgg gaatttacaa catcgtcgaa gttgaaatgt ctatgaaaat actggacagc 2398861 aaaatggctg ccgtcaaagc aaccgaagcg atcctcattg taacagcaaa tcctggctgc 2398921 ctgctgcaga tgaagctcgg cattgaacgc gaaggactaa gcggtaaagt cagagccgtt 2398981 cacctggctg atttgctatt agaagcagcc gggcacaaaa catcatgaga aagcccaaaa 2399041 cagacattgt tttgggcttt tgtgcgttat tccatcggac tgcaaatttc gatataatgt 2399101 ccatccggat cagcgatata ggcgaccgtc tgcccccatg gtttcacttt cggctccccg 2399161 ataatcgata cgccttgttc tctcatcctt ttgatgaccg cttctacatt ttcagtaaca 2399221 aacccgattt caaatgtgtt tgaagcagat gtatccggaa tgtccagcgc cgtgatgtct 2399281 ctggcgcttt cccgggtatt aagcgccaat atcgtagacc ctgtatcaaa ttcgacatac 2399341 gtgccgtgtt cagcacgaat cggcagtcct aaaatatccc ggtaaaaaat gaatagcccg 2399401 cttgctgtcc gatacgtata gaataagata tttcattgat agattcattg ccaacccctc 2399461 tcagcatttt caatagtcct tctagcccgg tatagatgct tccatcctta agctcggatc 2399521 tttccacatc tgcgcccatt ttttcacagc cgccacgata atgatgaagc ctaacaccag 2399581 catgatgata gataatacgc cattcaatac actatatcct gctgcttcag gattgagata 2399641 cacattgcgc accatccaat agcccgcata attgacagtg acatataaat aggcaagcgg 2399701 gataaggcaa gtcagaatgt accggcgttt atcggcgatt ttcagcacga tcgtcgctcc 2399761 gataatcagc cccactgaag ccatcagctg attagaaacg ccgaagagcg cccaaatgga 2399821 accgatatct cctgaataca gcaagtaccc ccacatcaaa caggcaagcg cgctggcaaa 2399881 tacagagccc ggaatccagt ctgttttctt cagcggctta tacacctccc cgaagaagtc 2399941 ctggatcaaa taacgggcga cacgtgtgcc ggcgtcaatc gctgttaaaa taaagaccgc 2400001 ttcaaacata atgacaaatt ggaaaaagta tgaggccaaa tggctgaaaa acggcattcc 2400061 ggtaaaaata taagtcatcc ctaccgcaag cgtgacggct ccccctgttc ttccttctaa 2400121 gtccaaaccg atttccccgc tcaattcagg caaatgtacg acattcatgc caagcgtacg 2400181 gaaaacctca ggcgtgctgt taatcgcaaa gtaatcagca ggctgtaaag cggtcgctgc 2400241 aatcagcgcc atgataccga caagacactc aacaagcatt gcgccaaacg caaccggctt 2400301 catatcactc catttattca gcattttcgg tgtcgttcct gagccgacaa aggcatggaa 2400361 cccagagatc gccccgcagg cgatggttat tgagatgaac ggccagacag gtcctgccag 2400421 caccggccct ccgcctttta cgaattctgt aaacgcaggg aacggaatgg acggattgac 2400481 gacaaacaca ccaacaatca aagcgataaa aacaccgatt ttcataaagc tgcttaaata 2400541 atcacgcgga gccagaagca gccaaacggg aagcgcagcc gcaaaaaacg cataaacagg 2400601 aagcgcgatt gcaagcgttt tcgtatctag cgttaaaaag tcaccgagcg cggtagtctg 2400661 tacccatgga ccgataaaga ctcctgccat taaaaagaga aagccgaccg ttgaagcgag 2400721 ctttaaattt cccgttttct tataaaataa gcccacaccc atcgcaatcg gaatcgtaat 2400781 ccccaccgca aatgttcccc atggattacg ttcaagcgca tgcaagacaa ccatcgacag 2400841 gcccgccatt gtgatcgtga tgataaacag catggacagt cctgtacaaa atcctgcaac 2400901 agggccaagc tcatccttcg ccacttccga cagcgatttt ccgtttttgc gcatcgatgc 2400961 aaacaacacc acaatatcat ggacggctcc cccaattacc gccccgatta acagccacaa 2401021 taatcccggc aaatagccaa actgcgccgc cagaattggt ccgaccagcg gcccggccgc 2401081 tgcgatcgcg gcaaagtggt ggccgaacga aacccattta tttgtaggca catagtcttt 2401141 cccatcctca agcgcatgag caggtgttgg cttgtcatca ttcactttga gaaccttcac 2401201 catcataaat gttccgtata aacgataggc aatagccaaa atacacattg atgctatcac 2401261 aattgtaacc gcattcattt tctcccatcc ccttttctgt ttttcataaa tatatcataa 2401321 tttcatggtg aaaagcggtc attttttcct atacaaaaag ccggctggaa tgggccggct 2401381 cgtggcagtt gaaagacaag ccggagagaa atctccggct ttgctattct tatgactgtt 2401441 ttttcaggcg gatcacattc caggaaagcg gcgtgaaatg agcagttaag ccgttttcgc 2401501 tgacagacga tgatccgttg gaatgcggaa cgacattttt tctgttatgc tggtttgttg 2401561 ctttgatatc ctgatgctca agtacgatgt gctctgcgat ttggtaggat tcaaagcctc 2401621 tgagcgaaat ctccgtctcc atctgatcct cagccttgtt taccgcaaaa atagtgagtg 2401681 tttcttcctc ttcagagtac acaacagcag catcaacata tggcacatca gtgaaatcag 2401741 aacaatcgta cttaggagaa gaaataagcg gtttcagtga ctcgcccctt ccgtaaacag 2401801 aagcatgcat gtatggatag aaaatcggct gtctccatgc ttctccgcct ttttccgtca 2401861 tgatcggcgc gatgacatta acaagctgtg caagacacgc aattttcaca cggtctgcgt 2401921 gctgcagcat cgtaatgagc agagagccga ctaataaggc atcttcaaaa ttgtaaatat 2401981 cctctaaaat cggacgcgca gtgatccacg gctcgacttt tttatcagcc tcatttgagt 2402041 ggtaccagac gttccattca tccagagaga gattgatagt tttcttgctg cgtgtttttg 2402101 cttttacata gtcacaggtc gcagcgactg atttgataaa atgatccaaa tccatagaac 2402161 gtgccaagta gtttggcaga ttgttatccc ggtttccgta gtaagtgtga agagagatat 2402221 agtcgacatg ctcatacgta tgctcaagca ccttcgcttc ccaatcgata aaggtcggca 2402281 taccgctgtt tgagctgccg caggcaacga gttcaattga tgggtcaacc cacttcatga 2402341 cctttgctgt ctctgcggca agccgtccgt attcatcagc tgttttgtgg ccgatctgcc 2402401 atggtccatc catttcgttt cctaagcacc atgttttgat gccatacggc tgttcatagc 2402461 catgcgatct tcttaaatca ctccagtaag agcctttcgg atggttgcaa tattcaacga 2402521 gattacgggc ggcatctatg cctcttgtgc caaggttgac ggccatattg acctcagtgt 2402581 tcaccttttt tgcccaagat aaaaattcat ttgttcccac ttcattggtt tctgtcgttt 2402641 gccatgccaa gtcaagccgt ctcgggcggt tttcgactgg tccgacaccg tcctcccagt 2402701 tgtatccgga taaaaagttt ccgcccggat agcggatgat gggaacctgt aattctttga 2402761 tcagcgactg gacatctttt ctaaatccat cttcatccgc ttcagggtga tcaggctcgt 2402821 atatgccttc atataccgca cgacccatat gttcgataaa cgagccataa atccgtttat 2402881 ctacttcacc gattttatat tctttgtcta caatcattcg cgcttttttc atcacacgtt 2402941 tcctccttca ttaacctttg actcccccta ccgtcaggcc ggagataaag tacttttgga 2403001 aaaacaagaa aatgataatc accggcaaaa tcgcaaatac tgagccggat ataagcatgt 2403061 cgtaattatt tccataaggg ctcagcaagc tggacagccc tattggaagc gtaaacattt 2403121 ctttcgaccg aagcacaatc agcggccaca agaagttgtt ccagctgttt aaggactgaa 2403181 ggataatcat cgcaccgaaa gccggtttca tcagcggtgc cataatcctg aaaaagatgc 2403241 cgaattccgt acagccgtcc atccttgcag agtccagcag atctcttgga aggccaagag 2403301 catattgcct gaaaaagaaa acagcaacag gtgaaacgat aaacggcaat atgacacccg 2403361 tatatgaatc gatcaagtgc agtccgacag taagtttaaa cagaggaagc atcatcactt 2403421 ccagcggaac catcataata atcagcacaa gaacaaagat gatatttctg cccttaaaat 2403481 cataaaccgc aagcccgtac ccgatcatcg aagaaaaaaa cagagtgagc acagtcgtaa 2403541 aaagtccgag tacaagactg ttaaaaaacc atttgaaata aatgctgccg ccattaaaca 2403601 gaaatgtgta gttatcaaaa ctcatcactt ttggatcaat atcaagattc agccccacac 2403661 gcaaaagctc agatgacggc tttaatgatc ctaaaagcaa acagaaaatc ggaaaaagat 2403721 acaataggct cagcatcata aaaaacaggg tcagcgcaat tctataaacg ctaaactgag 2403781 gactgtgccg caacatttat ccctccccct taaacgagcc tgacagcttt aatgaaatca 2403841 ggctgacaac aaggatcaca atcaaaagca caatgccgat ggccgctccg tatcccattt 2403901 cattgtaggc aagtccctgc tgatacaaat atccgacaag cgtcagacca atattacccg 2403961 gggaattatt ctgccaaagg acgtagcttt cctcaaacat cctgaagccg ccgatgatgc 2404021 tgatggtcag cacatatacg gttacaggct tgagaaacgg cagcgtgatg tgcagaaatt 2404081 ttttcattgt attcgcgccg tctatatcag cggcttcgta cagctctttc ggcacatttt 2404141 gcaaacctgc taaaaagtaa aggatgttga ttcccatcca tctccatgaa gcaagcagca 2404201 ccatcaaaaa catgccggta tgttcattgt tcatccagtt ctgaggtgaa aagccgagtt 2404261 taagtaggat ggaattggcc agagacgttt ccatttctcc gaagatcagc cgaaaaatga 2404321 tccccgcgac aatggttgag gtcaatgccg ggataaataa tgctgattta aatatatttc 2404381 taaatttgac cagctttgaa ttcaggaata tggccagaag caatggaaca ggaatcagca 2404441 cgatcagcgt ccaaaaggtg tattccagcg tattccaaag ggcggtatag aacgtcgggt 2404501 tgtttagcgc tgtataatta gacaatccga caaaggacac ctctcccggc aaaattcttt 2404561 ggaagctcat gatgaagaca ctaatgatgg ggtatagaaa aaatacgaga aaggataaaa 2404621 cgaatggcgc tgtaaacaga tagggcgccg ctttttttga ataaaacaga tctcgccagc 2404681 ctgattgttt cgcagctgaa ggaacgggat gaaccgttcc cgttttcaca ggtttcatga 2404741 gaacctcccc gctttcactt tttgaatggg attctatttc tgtttcagtt cacctgccgc 2404801 tctgtccaag gcttgtttag gcgttttttg ctgagattta agcgcgtcga acaatacgct 2404861 tctgttgaca aggtctgaag ccttggcaaa atcctcatgt aaataaattg gattgatttc 2404921 atccttgata tcgagcagca cagaaaaaat gcctgttccg ttttggaagt aatccgtgta 2404981 tttgtttttc tctttcaatt ccttggagct ccaaacatcc cagcgaagcg ggtcaaagcc 2405041 gagtacgctc cagagttttt tatttccttc ttcagagccc ttcgcaaagg ccaaaaactc 2405101 ttttgctaac tcaacatgct tggattgctt cggtacaaca gttgccgtac cgcccaaacc 2405161 tgccgagcgg tcgcccccct ctttccatgc cgggagcggt ctgatggcaa tcttcccttt 2405221 cagatcaggc atataatcga taaatcttcc catataccaa atcggcatga gaactgaagc 2405281 agctcctcct tggttcataa agccgtagta ttcttcactg tgatgcccgc cgcccggcgc 2405341 aggaatcatc gttttatcat tgatcatgtc ttttaaatat tgaagtgttt ttacgttggt 2405401 gtcattattg aggatcagct tgccgttttt atcaaaatag cctgagtttt gctgtgaaat 2405461 catagataag aacgttgcgg aatcatttgt ttccaccgtt cccatcggct tcccggtcac 2405521 tttgcgcact ttctgtccgg ctttatggta atcatcccat gttttaatat cgtcaggatt 2405581 gacgccggct tttttcatca catccatgtt ataaaacatg accgttgtcc ctacatgtgt 2405641 atcgagtccg taaagctttc cgtttttgct gtacaatgtc agccgcgcct caacgaattt 2405701 atcgcgatcc ttttcaatca gcggagtcaa gtcggcaagc ggtatgtcag agcccttcaa 2405761 aaagtttgaa aaacgggcca attcgacatc tgcaatatca ggaacgcctt ctcccgctat 2405821 tagggagata gataagttat cgtgcatttg tccatatgga taaacgaccg tattcagctt 2405881 aattttgcgg tcaggatatt ttttgttcca ttccttcacc atttccacat agaactgctc 2405941 atgaagcccg ttaaatgtcc aaaaggtcag ctcagtttca cccgatttgc cggatgattt 2406001 ttctgctgaa cacccggcaa tgactaatgt cagcaacatc atgagcacaa gaaaacagac 2406061 agtcattttt ttcatctgcg ttaccccttc cattcgaggt gcgggctatt catatagacc 2406121 atggttgatc agcgttttgt tttcattgat gattcttaat ccggtgcatc ggtctcttaa 2406181 ggtgtgcgcg tgtctgaagg catttttgac ggaatcctgc ccgacaccga tttcgtcaaa 2406241 atacgcaggg cctccggctg atctcagcca atcagccagc acttctcctc tcgggagtgt 2406301 ttgataagcc gattggatgg cttcccggcg gcttggtgaa aattcgttca gcccgtcatc 2406361 ctgagcgagc tttctgtatg tgtcagttaa taaaacagcg gcacagccca cctttgcccc 2406421 atgaagaatc tgaggccgtt ttttctccat taactccatt tcaatccaat gtgaaatatg 2406481 atgctcgccg cctgatgccg gtcgggaatg atctaatgcc agcatgacaa gccccgatac 2406541 aagtaaagac tccatcaaaa cccgtatgcc agtttccgtt ttcatcgcaa tgtcttctgt 2406601 gtgttcaatg caggcagcaa gcgcctcctg aacgatctta gctcctgcag gcgaataagg 2406661 ctcaccggca agatgccggg atatttccca atctgctaaa gacgtgattt taccgagcat 2406721 gtcaccaaag ccagccgcca ccattgactg cggtgccgct tttaatagat ccagatcagc 2406781 gaacagcgca gatggggcct tcgtttgaat ggttgttttc gtgccgtata aaataatcgg 2406841 cgcaccggct gatgtaaaac cgtctacaga tggagcagtc ggataagaaa taaacggcaa 2406901 atctctttga aacgccgcaa agcggacgat atcatgaatc gtgcccgaac cgactgcgat 2406961 catgacatcc gttggttgtt tcgtatggat cagcacatga atgagcgatc gttcatcagc 2407021 tgtcacatct ccggcttcat tttctggaat gatcaggcac tcggcctgaa atccttcttg 2407081 attcagtcgg ttttctaaat caattcctgc aatgcggtgt gtattcgcgt cgcagacaag 2407141 gacaatatgt tgattgtttt ttcgttttac ataatccaaa agcgaatcag ctgcttgctt 2407201 accgagaaca atttcttcaa cttttatagg caacgtcttt tctccggcgt tttcaaaagc 2407261 acgctgaacg tcagctgcga tacgattcat atcagaatcc cctcctcagc caatttggtt 2407321 acatccttaa tagaatccag cacataatcc ggcgtgtaca aacgctgttc accctgtttc 2407381 gcagaaccag ttagcactaa ggcgcttttc atgccataaa gcttccccat cgcaatgtca 2407441 gattcaatgc tgtctcctat aatcatgcat tcatgtgcgg acagccccat tgctgtacag 2407501 gcagcctccg ccatcagcca tgacggtttt ccgacaacaa gttcagtctt cgcttgtgca 2407561 gaagtctcaa ttgccccgat cattccggcc acatcaatgg catttccgtc ttcgttcgga 2407621 aaagagcggt ctttgtttgt agcgataata cgagcgccgc cggcagccgc ttgaaaggct 2407681 tgatttaaat cgtcgtacgt gagcgtttca tgaagggaga tcacgagcca atccgcttcc 2407741 ttcggttcgc tcgcgttctg cacaccggcc agcctcagct cgtcaaccaa gccttgctcc 2407801 ccaagcaccc atacctttga aaaacgataa tgttttttca gaaaagccgc tgtcacgctt 2407861 gatgacagaa caatgtcgtt tacgtccgtt tcaatccccg cgccaagaag tttttttctg 2407921 cacatggcac gggagatatt cccccggttg cttaaaaaga cgattttctt tcccattctc 2407981 ctaagcgttt tgatcgcttc tcttgctcct tcgatcaact catttcctct gaatacagta 2408041 ccgtccaagt caatcagaat gccagccggt gacacaggcg tatcatgact ggccataata 2408101 cgcatttgct ccgtgttttc gataaaaatg cttttcatgc aggactgtat tgattggggt 2408161 tacatccttg ttcagcataa tggagtgata ggccatttcg gcaaccgttt ctaatacaac 2408221 tgcgttatga atggcattta aggcgtcagt gccccagcag aacggtccgt gattattcac 2408281 gagcacaccc ggcacctgtt cgtaattatg atgctgaaag gtttccgcta tgacttttcc 2408341 tgtattcagt tcgtagtcat gaatgatttc ttcatcgtac atttctcgag tacatggaat 2408401 cgcactgtca aaataatcag catgggtcgt gcctaacgga gggatgtctc tgcccgattg 2408461 cgcccagctt gtcgcccatt gagaatgggt atggacaatt cccccgatat tcggaaaggc 2408521 tttatataga taaacatggg taggtgtatc tgaagaaggt ttaagcgagc cttcgacgac 2408581 ctctccatca aggttcaaaa caaccaagtc atcggctgtc aggtcgctgt attcgactcc 2408641 gctaggtttg atgacaattc tttctttttc acggtcaatg ccgctgacat ttccccacgt 2408701 aaaggttacc agctgatgct cttgaagctt caggttggca gccagcactt ctttttttaa 2408761 tgtttcaagc atgctccatc accctttatc aattcttttt ggcggcagat gaaaattgaa 2408821 gatttttgat cgttttcaga cgcttcatga catggttttc ttttccgaaa taatgaacca 2408881 gctctttata ttcagcgtac aatttttcat aaaccgcggc gttttcggca tttggcgtat 2408941 aagttatatc tttcagtttt cccatgttcg ccgctgcctt tttgatatca tcgtagccgc 2409001 ctttttcttt gcctgctgca agcgcgccga aaatggcaga tcctaaggct ggggcttgcg 2409061 gtgaaccaga gattttaatg tccatgtttg tcacatccgc ataaatctgc atgacaaacg 2409121 ggtttttctc agctattccg ccggctgcga acagttcctc aatcggaaca ccgctttctt 2409181 tgaatgtttc gataatcatc cgggttccgt aagctgtcgc ttcaactaac gctctataaa 2409241 tctcttcagg cttcgtcagc agtgtcatgc caagcagcat ccctgttaaa tctgcatcaa 2409301 caagagttga acggtttcca ttccaccaat ctaaagcaag caagccgctt tcaccaggcg 2409361 cttgatggtt tgctttctca ctcagcagct catgaacgcc aatgtttttt tcctttgctt 2409421 cctcttgata agctggcggg acacatgttt tcacaaacca gtcaaaatga tcgccgacac 2409481 aggactgccc ggcttcatat cccgcatagc ccgggagaat tccgttgtcc acaacgccgc 2409541 acattcctgg aacgatatgc acctcttcac caagtagaac atggcacgtc gaggttccca 2409601 taatcatcag cattttccct ggctctgtaa tgccgaccgc cggtaccgaa acatgagcgt 2409661 ccacattggc aaccgcaaca gccgttcccg ggagaagccc tgtcagcttt gccatttttt 2409721 cagtcagact gccggctttt tctcctactg aatgaataga acctgacaat ttgtcctttg 2409781 taatcgtttt cattgaagga tttaatttct caaagaaatc atctgacgga taccccgctt 2409841 tttcactcca catcgcttta taccctgcgg tacaattgct tcgcttgagc gagccgcaca 2409901 gctggtacac gatccagtcc gcagcctcga tgatccggtc agccgcttca taaatgtgag 2409961 gcgcttcctc ggcaatttgc atgacctttg gaatcatcca ttctgatgaa atttttcctc 2410021 cgtaccgctg taaaaaagcc tctccttctt cttccgcgat ttgattgagc cgatcagcat 2410081 gtttttgggc cgcatgatgc ttccagagct tcacatagct gtgcggctcc tcttcatatt 2410141 caggcagcat gcataacggc tgcccgctgc tgtcaatagg aaggatcgta catgccgtga 2410201 aatcaattcc aatcccgata atgtctttcg ggtcaacgcc cgtctgttcg agtaaagacg 2410261 gaatggttgt ttccaagact tcgaggtaat cagcagggtg ctgcagcgcc cagtcacgcg 2410321 gcagcttttg acccgttttt ggaaggacgg tatcaatgac agcatgcctg tattctttta 2410381 cagcagccgc aagttcctcc cctgtttgga catgaacgag cactgctctt cctgataaag 2410441 ttccaaaatc aacccctatt gtgtaagcca tgtgacatcc ccctctactt ttgaagccgg 2410501 taaagcgcct cgttccattt taactcgtgt ttcagtttat gaattgtcgt atcacgggaa 2410561 atgagaacac tttcgattcc cgccatttcc gcccaatcaa gcatttgctc cgctgtcagt 2410621 tcataagaca ggcaggtatg gtgtgcaccg ccggctaaaa tccatgcctc cgctgctgtt 2410681 ttcaatgacg gctccggctt ccagagaaca cgggcaaccg gtaaattcgg catgtctttt 2410741 tcaatttcct ggccgttgac ttcattcagc acaaggcgga aacgcccgcc aatatcaaca 2410801 atgctagctt gaatggcaga accgctgatg ccgttaaata ccaaacgcgc agggtcctct 2410861 ttgccgccaa tcgaaagcga atgaacctcg attttcggct gatccaaagc gacagtcgga 2410921 cacacttcaa gcatgtgaga gcccagaatc atttcatttc ccggttcaaa atggtacgtg 2410981 taatcttcca tgaaggaagt tctttttcct ttagccatga ttttcatcat ccgtacaagg 2411041 gccgctgtct tccaatctcc ttcaccggca aacccatagc ctttctccat caggcgctga 2411101 acggcaagtc ccggcagctg tttcattccg tgcagcactt caaacgatgt cgtaaacgct 2411161 gtgtatccgc cttgctcaag aaaagcggtt aatccaagtt caattttcgc ctgttcttta 2411221 atggacgcta cctttgcttc gtcacgtttt gtttcctcac tgatcacata tagtctgtca 2411281 tactcggcat aaagcgtgtc aacctcgtcg tccgtaatgc gatccatcac ttcaacgaga 2411341 tccccgatgc catatccgtc aacctgccag ccaaattgaa tatgcgctcc caccttgtct 2411401 ccgtccgtta ccgcgacatg acgcatgtta tctccaaatc tggcaacctt aatatgtctg 2411461 ctttcattta atgcagccgc cgtatccatc cactgggaca tttctttttt cacttcttca 2411521 tcatcccaat agccggcaat gacttttcgg ctaagcccca ttctcgagtt gatgtaaccg 2411581 tactctcgat cgccatgcgc ggattggttg ctgttcataa aatccatgtc aatcgtaccc 2411641 cacgggatat cgcgattata ttgggtatgc aaatgcataa gcggtttttg ataagaggaa 2411701 aggccttcta tccacatttt tgcaggggaa aatgtgtgca tccatgtaat gatgccagca 2411761 catgtctcac tgtactccgc ttctcttaac agctctctaa tggtttccgg tgaagtgacg 2411821 acgggcttat gagtgatttt atatctggaa gaaatcccgc tgagcccctc acaaatgctt 2411881 ttagcatgct gatctacgag ttccagcgtc tcttccccgt ataggtgctg gcttcctgtc 2411941 acaaaccaga attcataatc ctttgtctga agcatgtaaa ctgccccttt ctcataaaat 2412001 aaaacgcttt caaatacaaa agatacgtac taatgataga aaataaacct ataaataaat 2412061 atttgtacga acaattttat tatagtaatt gactattata ctgtcaatct tttcttttaa 2412121 aaaaagccgg gggcagagcc cggcttttta attcaatagg acggccagcc cgagctccaa 2412181 ttcaaatcat tgatgagaag ctttggaatg ccgttgtcat tggcatcata ggcatggcga 2412241 acaagaatgt ttccgttcac aatatcctgg cctccaggtc ctttccattg gtcattgccc 2412301 gaatccaaaa tggtgcctcc gccttcaagc atgctttttc cgcttttatc aagataaggg 2412361 cctgtaatgc ttttggatct tccgtaagca attttgtacg tactgtttac cccgtcacag 2412421 catttatcaa atgaaaccat taaatagtaa tatccatttt gatacgtaag agtaggagct 2412481 tctaaggcac ctccattatt cggtctagct gcaatcgaat agagcgagcc tgtaggcttc 2412541 attgtactct tatcgagctt agtcagctta atgccgctcc aaaacgagcc gaatgcaagc 2412601 cacgggttgc catccttatc gaatgtcagc tccggatcaa tggcgttata attatttgag 2412661 cttgtcgaac ggatcaccaa gccctcgtcc ttccagcccc ccgaactgat gcttgttgaa 2412721 gatgccaggc caatggcaga tgtattgctt ccaaaagaag aaacggaata atatagccag 2412781 tacttgccgt tatagtattg gatgtccggc gcccactggt tttggccata attcggcaca 2412841 taattggacc accacgatag cggtgtagtg aaaatggatt tttgtacggt ccaattttta 2412901 gcgtctgaag acttcaaaac ccgcagtccc cgttcttcag taagccctgt tccgagcgca 2412961 taccatgagc tcccctcttt aatcatagtc gggtcatgaa gcagctcatt ggatgcaccc 2413021 caaaacgctg cctctgcggg agcagcagaa gtgaatatca aacctgcagc cagagctgca 2413081 ctcgaaaagt gtaagaagcg tttccatgtt tttttctttt tcaattttgt tcaacctcct 2413141 ttattttaga aagcgcttac aaattagatt atttatcctc ccttcctgtc aaatcgactg 2413201 cgtatcgtat atcgtcatgt tcaggaaatt ttcggtatcc cctttattgt agtcactatg 2413261 ctgtaatttg tacagacaaa aaaatagaat ccacctcaat aggcggattc ttccgtatct 2413321 ttattggtac gtaatttcgt caaccgtttt tcggtctaac ttcttaatga cttctgtaat 2413381 taactttacc gcgttttcat aatcatcacg atgcagcatg gccgcgtgcg tatgaatgta 2413441 gcgggttgca atggtaatgg acagcgcagg aacgccattt gccgtcaaat ggatggcacc 2413501 cgaatcagtt ccgccgccgg caatggcatc aaattggtac ggaatgccgg cttcctccgc 2413561 agtggctaca actgcatcgc gcaaaccttt gtgagagacc atggatgcat cgtaaacgat 2413621 aatctgcggg cctttgccca ttttgctctg cgcttccttc tcggaaatgc caggcgtgtc 2413681 tcctgctatc cctacatcaa caccaaacgc aatatcaggc tgaatggtgt gtgcagccgt 2413741 tttcgctccc ctcagcccga cttcctcctg cacggttccg acgccataca ctatatttgg 2413801 atgatctgtg ttttgtaagt ttcttaacac atcaatagca atcgcacagc cgatgcggtt 2413861 gtcccaggcc tttgcgagta ggaatttttc attgttcatg accgtaaatt caaaatgcgg 2413921 aacgatcata tctcccggaa gtacacccca ctccaaggct tcttcccggc ttgaagctcc 2413981 aatatcaata aacatgtctt ttatttccac tgattttttt cttgcttcag gagacaaaat 2414041 atgaggcggc ttagatccga taacccctgt gatttctcct ttttttgtga caatggtgac 2414101 gcgctgagca agcataacct gagcccacca gccgccaacg gtttgaaaac ggataaagcc 2414161 tttatctgtg atttgtgtca ccataaagcc gacttcatcc aaatgtccgg cgatcataat 2414221 tttcgggccg ttttctgcac cagttttttt tgcaattaaa ctgcccaggc gatctgttgt 2414281 cacctcatca gcaaatggtt ctatgtatga tttcatcact tgccttactt ctctttcatt 2414341 gcccggtatg ccttttgcat ctgttaaatc tttcagcatg gtcaatgttt catctaattt 2414401 tgccatgttc caaaccctcc ttcatcagtc ctgcattctt attatacaaa acatggcgct 2414461 aaccatacga ctatttcact tgaaaatcgg gtatatgttt ttacagcttt cttttagaaa 2414521 aagtgaaacc tttttctatg cttttcgtat tacatcagat catcaccata agggaggtgc 2414581 cttcacacaa tgtttgtcat ggttctaagg attattttgc ttgcactttt tgcttattgt 2414641 atttatgccg tggtcaaata tgtcgcgaat cctaagagaa ggcttaagct ggcccaatca 2414701 aaagaacatt tttatattat tgatgaacaa aacaataccc ggaagaattt tcagctgacg 2414761 tataaaggcg tgctttttga gggagaaaag catattcctt ccaaggatca tccgctgttt 2414821 attcacacga tctttgtctg gacagaatct cctgagaagc tgaaacattt ctctgcaaaa 2414881 gattttgaga acattgaaga aaaagtgctg gaacgatatc caaattgtaa gattgactgg 2414941 gaccagccca ttaaactcgc aaaaaaagca gaagagcgtt aaacgctttt ctgcttttta 2415001 taaatcaaac gggctgtagt aaatagcgat gagaatcgct tctattacca gaagaagcgg 2415061 tactccgtac ttaaaagaag cgtgtttcgt tttatgtctg aaggtttgca tgccaagcca 2415121 gacaccgagc gctccaaaca cgatggctat cagccacagc cggtcttcag aaattctcca 2415181 cttgtgctgc tgcgctttgc gtttgtcaat gcccatcacc caaaaaccgc acagattaat 2415241 caacaccaaa taagcagcaa taatcatgtt gcctcatcct ttatatagaa aaagccgctc 2415301 tgctggagag cggctctata tgattacttg tttaattgag ctttagcagc atcagcaagc 2415361 tgattgaatg cagtaagatc gtttacagca agatcagcaa gcattttacg gtttacttcg 2415421 ataccagaaa gcttaagacc gtgcattaaa cggctgtaag aaaggccgtt catgcgagca 2415481 gctgcgttga tacgagtgat ccaaagttta cggaaatcac gttttttctg acgacggtca 2415541 cggaaagcat agtttccaga tttcatgacc tgctggttag ctactttgta taatgtatgt 2415601 tttgaaccga aataaccttt tgctaattta agaacctttt tacgacgctt acgtgtaaca 2415661 gttccgcctt ttactcttgg cattgaattt ccctcctaat tgttccttat ccgattactt 2415721 gatgttagca agcatttgtt tgatacgttt gaagtctcct gcgcttacaa cagcactctt 2415781 gcgaagctta cgcttttgct tttgagattt gttggcgaat aagtgacttg tgtacgcgtg 2415841 agaacgtttt aacttcccag aacctgtctt tttaaaacgt ttagcagatc cgcggtgagt 2415901 tttcattttt ggcatgggat ttcctcctta ttgcttttcg tttttcggtg cgagcattaa 2415961 gaacatgctg cggccgtcca tttttggttt tgtttcgact gtcgcaacct cagcacatgc 2416021 ttcggagaaa cggtctaata cacgctgacc gatttcttta tgagtgattg cgcgtccttt 2416081 aaagcggata gaagctttca ctttatcgcc tttttcaagg aatttaatcg cattgcgcaa 2416141 tttcgtgtta aagtcatgct catcgattgt cggacttaac cgaacttctt ttaagttaat 2416201 gattttttga ttcttgcgtg cttctttttc ctttttctgc tgctcaaatc ggaacttacc 2416261 gtagtccatg attcggcaga caggcggttt tgcattcgct gcaactaaca caaggtcaag 2416321 atttgcgcgg ccggcgattt caagtgcttc ctgacgggac ttgattccaa gctggtcgcc 2416381 attttgtccg attaaacgga cctcacgtgc acggataccc tcattaacca attgatcttt 2416441 gctaataatg agccacctcc atagtttctt cgaattgatt cacaactcat tttgaatgca 2416501 ttttgcaggc aaacaaaaag tgtgggcatt ataaaacacc cacactacga acatctgtat 2416561 caataaaaat gtacggtcaa cctgccaact acatgcatgt gtcaatcagg tgagaagcgg 2416621 gtgcttctgc ttgtgattta tattcaattc aataactatt ctacacaata ccggatcttt 2416681 agtcaaggac gacttatccg gaacaacttt tacattgtaa catgggtttt ctatgagcgc 2416741 aagagagaaa aagaaaatct ttcatcccca cccagaatac aaagaaccaa caattccccc 2416801 ttattacgca atttacaaca aaaccaccga caggaagaaa tgtaaaacaa agttaatctc 2416861 tgaccgatat aaggagcaga agggagcctg acacatgaac aaactgatac agcttgcttt 2416921 atttttcaca ttgatgttaa ccggttgctc gaatagcagc acatcttccg aatcaaaagt 2416981 cgaaaccact gttaagacaa cggcagcatt tcctcaaaag gagctggaga aagagctaaa 2417041 aaaactaaaa cccgtttcat tggacatgaa gttcgagagt ccactcgcta ccgagttagg 2417101 aaagcggaag gcaaaagagg aagctgaaaa gcaaagacaa atcgccgctg agaaaaagct 2417161 tgaaaaagag cgggaggcga aacgaaagaa acagcaggag gaaaaagcgg agagacagcg 2417221 attagcagag cagcaggctg cagagagaca gcgattagcc gaagcggaaa gacaagctga 2417281 acttgaaaga cagcggcagg cagcaatcca aaaagagcag aaagcgaacg ctgagaaaaa 2417341 gcggcaatcg caggcacaac ggcagcagac tgaggcaccc tcatctaata gtcaagatcc 2417401 accatcttcc tcgagtcaga cagataaaac cattcaacag ccagcttcag agcttcctga 2417461 tgacgatggt tatggttatg aagaacgaaa aaagtggcat gacgatcaag tagaatgggg 2417521 cattaaacaa gggtatatcg atcccgaaga cgcaccataa aataaaaaaa gccaaggcat 2417581 tcagccttgg cttatcctcc gatcagctgc acgaacacag ggatgaccag aaccgttacc 2417641 actcctacta cgacaacagc aatacttgcc atcgcagctt caacttctcc catctcaatc 2417701 ccgaccgcta caccaagtgc atgtccggat gttccaagag ccaatccttt agaaatcgga 2417761 tttttcactt taaacacctt caagaacaat gctccgagcg catatacgat gacagcgtta 2417821 aagatgaccg caaaggctgt gatgtcgctg atgcccccga tgccttttga taaaggaagc 2417881 gcaattgccg ttgtagccgc ctgcggaagc atgcttttca ttacggccga atcgagatga 2417941 atgcctttag cgagcagata aacaatcgtg acagagcaga tagagccggc aataatggag 2418001 gccatgattt gccaccagta ctttttaagc ttatctcttt gtttgtacaa aggaattgca 2418061 aatgcgatcg ttgccggttc aagaaaaaac ttaatgatct ctcccccgtt attataatcc 2418121 gcgtaggaaa aaccgccgat ttttaaaaat gcgatcccca gcaccatggc aacaaacaaa 2418181 ggagtgaaaa ggaagaagcc tttcgttttc ttaaataaaa aggtgccgat gccgaatgca 2418241 gcaagtgata cgacaatccc aaaataagga ctcattgtgc tttccatgtg aagaacctcc 2418301 tgtttccctt aatggtgaac gagttcgtta ttgttctgcg ggctttgcac tgtttttgtt 2418361 ttcatgtccg cttcggtttt gcgttttccg ctcagcgaca gaatcagctg agaaaacaat 2418421 cccgtagccc ccagcaaaat aatcgttgcg agcagaatga caagaacaat ttgcaggccg 2418481 tattgctgca tcacaccaag cgaattcata acagatatac ctgatggaac aaataaaaat 2418541 ccgatcagag aggttaaaga cgttccgagc gtctccactt gttccagttt aatgactttc 2418601 aaacataata ggagaaataa taagaccaac cctacaaccg atgccgggat aggtattggg 2418661 acaatagcgg caatcatatt tgaaaccagc ataatgacgg caaaaataaa tgcttgtgtt 2418721 aaaaacccgt acactttttt agcactcatt ttcttcacct ctttctcttt ggtaccctca 2418781 ttataaataa gaattccctg ttataaagcg cttacaagat aacatgccgt atagcgggtc 2418841 tgagttgcag aatcaaatgg ctgaaatgca aaaagccgcc catcaaatat ggagcagctt 2418901 tttcaattcc ttcgcatatg tccggctgac cggtattttc gatccgtctt tcatgatcag 2418961 attatacgtt gaattaaacc atggctgaat ttctttaata tattcagtat tcacgacaaa 2419021 gctccgatgg acgcggataa aatcagaatc cggcagcttt ttctcaatca caacgagtgt 2419081 atcgctgacc gtataagaat gatcgaaggt ttttacattg acatgaccat cttctgttcc 2419141 ggcatagata atgtccttcg tatccacaat cacaatcgat tcccccacag atagcgcgag 2419201 cttgtgctgg ccggcatggc tgttttgctc tgtttctaca atatcccgat tgactttttt 2419261 atattttttc agcgtttgct gaattctttc ttcatcgaaa ggcttggtta aataatcaag 2419321 agcgtccacc tcaaacgctt tgagcgcata ctggtcatac gctgtcgcaa acacaatagc 2419381 aggaggatgc ttcattttct tcaatcgctt tgcgatatca aaaccgtttt ctccggataa 2419441 atcaacgtct aaaaacagca aatcaggttt ttgatccatc atttggtcaa aagcggattc 2419501 gatattttcc gcttcattga tttccatttc atcattggtc cgcttaagca agtaagccag 2419561 ttcatccctt gccagcatct catcatcaac tattaacacc ctgagcatgt tcttctccct 2419621 ctttcatctg ttgcattggc acttgaaagg aaacctctgt ccctttatga acctcactgc 2419681 tgatatgcag tgcagcctgc tgtccgaata aaccgatcag ccgctgattt aggttataaa 2419741 gcgctgtacc ggttccctcc ttagacggaa acggtttctt ccccagttcc ggcaagacgt 2419801 ccggcggaat tccgcgtccg ttatccgcca ccttcatata gacggatgca tcatcagata 2419861 agacacagac tgtaaccttg catatgtctt gttttttcgg aaacgcgtgc cgaagcgcgt 2419921 tctcgacaag cacctgcaaa acaaacggag ggatttcaat ctgctccagt ctgctgtcga 2419981 tattaagctc aattttatat ttcccgggaa aacgcgcctg ttctaatgac aaataggcgt 2420041 taagatggtt cagctccttt gagagcggaa tcagcagctg tctcgctcct tgaaggtttg 2420101 aacgaaaata aacactgagc tgcaatagga gcttacgggt tttttcaaca tctgtacggc 2420161 ataacgcaga aatcgtgttg atcgcattaa ataaaaaatg cggattcacc tgtgcttgaa 2420221 gcgctttaat ttcagcatcc ttgagaagtt tgctttgcag ctctgcttcc ccaagctcaa 2420281 gctgtgtcga aaacagcatg gccagcccct cggcaagttc ctcctctacc tgactcaggc 2420341 ctgccgggct tttaaagtac atttttaagg tgccgattgt attgccgttc gatgtcagcg 2420401 gtaggacaat tgcagcgtgc aaagggcatt cagcatgcgt gcattcaatc tcttcctgcg 2420461 aaatcgcctt cataatatgc cctgttttaa tcaccttttt ggacaggccg gtgatcaagc 2420521 ttttcgatgg gatgtggtga tccattcccg caccgacatg cgcaaggatc ttttctttgt 2420581 cagtgagaga caccgcatct gttcctgtca gcttatggat aatagccgct acacttttac 2420641 aggagttttc atttaatcct tggcggaaaa atggaagtgt ctgatcagca atcgtaagca 2420701 ctcgatgcgt ttcgagagcc cttgcctgtt cttccttgcg aatgatcgct tgaataatag 2420761 acagaaaaat aaaactgcct gttccattga tgagtatcat cggaattccg atcatgctga 2420821 caagctccca agcgtcactg aacggctttg ccatcagcaa aataatgatc atttgcagtg 2420881 actccatgcc gattcccaca agagcggcga tgcgcggtgt cggcattcga tatcgcttcg 2420941 taaaatacct gccgatcaag cctgcaagaa cacccgctaa aatagatgag acggcacagc 2421001 ttaaggccgt gctgccaccg agtgaaaaac gatgcaggcc cgcaagtatg ccgatcccag 2421061 cccctacaaa aggacctccg agaaggcccc cgatttccac gcccaaaata cgggtattcg 2421121 cgatagagcc cgatggatct atcgtaaaca cccagtcatt gtttacaatc atatttcttt 2421181 gaatttcgat gcctgtataa ttgctgatga tgctgaaaag agaaaaaata gaaattaaaa 2421241 tcgcttttcc tttatagccg tcctgattct gaagagcttg tctgaaaagt ttcgtatggg 2421301 cgagaatgaa ccctaatata acaataatcc ccactctctc cagcatcata atcattaaat 2421361 gaatcattca tgtcacctgt tctttccgtt ttcattctag catgttttcg ttttgcggct 2421421 gactgttttt ttaaaatcgt ctgaaaacat atttcacaag gcttttatct attgtaaaat 2421481 aaaacatgag ccttttggca gaaagatttg aatctgaagc agaggagaag atcatgaaag 2421541 ccgtattttt tgatttagat gatacactac tttgggacga aaaaagcgtc agaacaacat 2421601 ttgcagaaac ttgcttacag gcggagaaaa aatatggcct tgcccctgag gaattcgaag 2421661 cagctgttcg cgaagcggcg agagaattgt acatgtcata tgagacgtat ccatatacag 2421721 tgatgatcgg cattaacccg tttgaaggac tgtggtccaa tttctcagag ccaatcagtg 2421781 aaggctttca aaagctgaac aagattgtgc cggagtacag aagaaatgca tggaccaacg 2421841 gactgaaagc gcttgggatc gatgatcctg catatggcga atacttggga gagttttttg 2421901 cggcagagcg cagaaagcgc ccgtttgtat atgatgaaac ttttgctgta ctcgatcaat 2421961 taaaaggcaa gtatgaatta ttgcttttga caaatggcga tcctagtctg caaaaggaga 2422021 agcttgccgg cgtgcctgag ctcgctcctt acttcaatga aatcgtcatc tcgggcgcat 2422081 tcggcaaggg caagccggat gtttcaattt ttgaacactg ccttaagctg atgaatattg 2422141 aaaaagacga tgccatcatg gtcggcgata atttgaatac tgatatttta ggcgcttcaa 2422201 gagccggaat caaaaccgtt tggatcaacc ggactgataa gaaaaacgaa actgacgtaa 2422261 agcctgatta catcatcagc agccttcatg atttgtttcc tatattagag aaataaaaaa 2422321 agcatgatct cttcaatgag atcatgcttt tttattttat tttttcgctt cagctactgc 2422381 ctttttcaca aactcatcaa gtgaaatggt ttcagagttc tgttctccgt atttacgcac 2422441 gtttaccgct ccgttttctg cttcttggtc accgaccacc agcatgtacg ggattttttg 2422501 catttgcgct tcacggattt tgtagccgat tttttcatcg cggctgtcga cttcaacacg 2422561 caggccttca cattgcaggc gttcctgcac ttttttcgcg tagtctaaat gcacagccgg 2422621 agaaaccggg atgacttgga actgaaccgg tgcaagccat gtcggcagcg cgcctttgtg 2422681 ttcttcgatt aagaaagcaa caaagcgttc cattgttgaa acgacacctc tgtgaatgac 2422741 aaccggacgg tgctgcttgc cgtcctcacc gatgtatgtc aggtcgaaac gttccggcaa 2422801 taagaaatca agctgaaccg tagacagtgt ttcttctttt ccgatcgcag ttttcacctg 2422861 aacatcaagt ttaggtccgt agaatgccgc ttcaccttct gcttcgtaat agtcgtggcc 2422921 gatttcatcc attgcctctt tcagcatgga ttgcgctttg ttccacattt catcgtcatc 2422981 aaaatatttc tctgtatctt ccggatcgcg gtaagacaga cggaatgtgt aatcacttaa 2423041 accgaagtct tcataaacat cctggattaa acggactgta cggataaact catccttaat 2423101 ttgatccggg cgcacaaaga tgtgtgcatc atttaacgtc attccgcgta cccgttgaag 2423161 tcctgacagc gcacctgaca tttcatagcg gtgcatcgtt ccaagctctg caatacgaat 2423221 cggaagctcg cggtaactgt gaatgtcttg tttgtaaatc atcatatggt gcggacagtt 2423281 catcggacgc aatacaagtg tttcattgtc catttccatc ggagggaaca tgccttcctg 2423341 ataatgatcc cagtgtcctg atgtttcata cagctctttg ctgcctagca caggtgtgta 2423401 tacgtgctca tagccgaggc tgatttcttt atcgacaatg tagcgctcga tgacgcggcg 2423461 gattgttgcg ccttttggca gccaaagcgg caggccttgt ccgacttttt gagagttcgc 2423521 gaacagcttt aattctttgc caagctttct gtggtcgcgt tctttcgctt cttctagcat 2423581 acgaagatgc tcttcaagat cagctttttt gaagaaagct gtaccatata cgcgctgaag 2423641 catttggttt ttgctgtcac cgcgccagta tgcgcctgca aggcttaaca gcttaaattc 2423701 tttgattttt ccggttgaag gaacatggac gccgcggcac aggtcaaaga attcgccttg 2423761 ctcatagatc gaaacggttt ctccttcagg aatcgcatcc aatagttcaa gcttcaggtc 2423821 gtcgccgatt tccgcaaaac gggctttcgc ttcttcacgg ctgacttctt ttcgaacgat 2423881 cggaaggttc gcattaacga tttttttcat ttctttctcg attttcggca gatcctccgg 2423941 tgtaatcgct tcgtccattt ctacatcgta gtaaaaaccg ttttcgataa ccggaccgac 2424001 gccgaattta acatccttgt agatgcgttt aatcgcttga gccagcaagt gagccgcact 2424061 gtggcgcata atttgaagac cttcttctga gccttctgta atgatttcca ctgtaccgtc 2424121 ttcattgatc ggcgttctca aatcgatttc ttttccgttc agttttccgg ctaatgactt 2424181 tttctttaat cccggactga tggatgccgc gatatcttct gttgttgttc ctttcgcaaa 2424241 ctccttgact gctccatcag gaaatgtgat ttttaccata tctgacatct ttgtcactcc 2424301 tttttttgca tataaaaacc ccgcccccta tgaaagggac gaggttgaat aaacggaatc 2424361 gtggttccac ccttttttcc gcaaagccaa tacacggcac ctgcggctct aagctctgta 2424421 acgggagttc ccgtcagcca ttactgttcc ttttcaagag gttcacagct gaagttcaaa 2424481 ggcggtaaag cgaatggtcc ttagctggga agcttgcagc cagggcttcc ctctctttga 2424541 gccggtatca ttccttcgtg tccttatcaa tacgtgtgtc tttcttaatc tcctatgtat 2424601 tataaattgt tcaatccaaa aaatcaacac gatcgcgttt cctttttttt aaaccgacag 2424661 ccttaaatag acaggctgcc ggccctcatc cttccgagtg cttcaccggt atttctgcat 2424721 ctgtaaaagc atgcagcggg agcatttcca ctctctcttg aaatacgttt tgaatggtcc 2424781 ttgccatcat gtgctcgggc tggtcggtat aaagcacgac ttcatcaggc gcaatggaaa 2424841 tcagcggcgc gagcaaatga gaatcaatat acataggatg atcccggaca aatcttctgt 2424901 ctatgtattt cattttttcc cgttccggca catagcgcag ctcccataat gtaaaggaac 2424961 catcatggac aatatgcact tttttgattc gcggctgttt ggcgtccaca tagtctctga 2425021 gtgtttgaat aaagttttga tattcctgtt ccatcttata ttcatcaatc gctgcttctg 2425081 taatatctct cagctgctta tagtatgatc caagtcggaa ggtctgaaag gagcgaatgt 2425141 aaaatactcc ttcctctaaa cagatcgttt ggagttcatc caaaattgat tgtttccgtg 2425201 aaagcttcag cggctcaaac ggaagatcgt ctgcttcacc ttcaataata ctgtgtgcga 2425261 gctgaaggat ttgctgctgt tcatcctggt ccgtgaaaca atacgtttcc tcaatcaatg 2425321 acagcatatg ctcgtcttct ttgcattcca aaaaaaattt gaccagaatc ggctccataa 2425381 aacgctgaat aggaaaagcc ggattcgctt tttcaatccc gatttttcgt atgccttcac 2425441 ggacaatgat attgttccga tcgtccgaat gctgaatgag atgtaaaaaa gcggctgcat 2425501 catggtcatc ttcaaagatt atttcaagca tgtttgtccc cccttacggc atctgttaca 2425561 agtatatggg ggatgttttt aaaatagacg taaaggtcat tggcaaatct taatttgatt 2425621 cttggaacaa gttttgcatt ttctttctga agatgaacgg caatgagata aacacgatat 2425681 acaaagcgag caccataaag aaagcgggca gattgccagc caaaaagctc gcacccagca 2425741 cattaagcgc aatcgtccca gggatgattc ccacagccgt tgcggcaaaa tacggcagcg 2425801 ctttgacatt ggaaaggcct gccgcatagc tgacgaaatc aaaattgatc ggcaggattc 2425861 tcaaaagaaa gatatagaaa aatccgttat cctccatttg cttctgtatg gcttcaagcc 2425921 tttcgtaatg cccgttcttt ttcgccgaaa acaaaccagc cgcaaaaaac gaaacagctg 2425981 aagcgcacat cgaaccgaat aacgtataaa gcgtgccgag aagcgggcca aacgcaagtc 2426041 cgccagctat tgaaataaca gacaccggaa ataaaacaag tggcctgacg atggatatcc 2426101 cgataaacat cagaggtgca aagactccga acgacaatac ccataccctg atttctttcg 2426161 gcgatacatt caaatacgtt ttatttcccc aatagagtaa accagcacct gcaagcactg 2426221 ccagccattt gacagccgtt tttcgtttca taccctcagt tccttcccct ttgaaccaca 2426281 gcaattatgg atgtcggcgg ttttctccgt caaggcggat cggagcagcc aaatataata 2426341 tccgctccat taatcttgca gcttttactt cttctttttc tcccctctgc gaatacgtaa 2426401 aatgatgctt cagctcgtca ggtgagaaat tagaagaaaa gaacgttggc agctgctggg 2426461 acattctgtg ctgaagcacc gttccgatga cctcatccct tacccagctt gtcattgatt 2426521 ctgctccgat gtcatcaagc attaatacgg gtgtggtctt taccatattg agcttctctt 2426581 ccaatgtctg gtcttgcagc gaattcttaa gctctctcac aaattcaggc acataaacaa 2426641 tcatggagga atactctttt tccgccagct cattggcaat tgcagcgagc ataaacgttt 2426701 ttcctacccc aaatttcccg tataaatata atcctttccc ttttcccgtc tcattatagc 2426761 ttttcaggaa gtctgtaaca tgctgaaaca tcgcgagtct gcttgggtca ctgatatcaa 2426821 cttgctggaa cgtcgctcca agaagatcct gctggatata catgcttttc ataagagact 2426881 gttgtttctt ctgctggtcg agcttccgtt tgactggaca ttcgtaatac tcgatatcaa 2426941 tagacctccc attgacaaca agcttcggat ggtagccctc caacaaattg ttgcagtttt 2427001 catcttccga acaataggag caattcttgc tttgttcgat atattcataa agcttattta 2427061 agctcttttc gatcattttt tggtcaatca cttcttcgtt ttccttcaaa aatgcttgaa 2427121 catcttgatc tttcatgact ttttccttca tttgttcaag acgtttttgg aaatccggcc 2427181 tgccggttac gccctgcagg gaacggccga ttggttccat ctattccttc accccgcatc 2427241 tctgtcttta ataggcagag tattttttca gtttttgcat ttcttccatc atctttttct 2427301 tctgttcttc caaatcctgc ggatgcagct tctgctgtcc ggattctgaa tcggacgctg 2427361 tttccttttc tgtcatccaa tcaggaagct tttcttcacg aatcactttt tggtttcgtt 2427421 tcgaagactt tgtttttccc tcagcccatt caagatactg gcggttttct tctattgcga 2427481 gcttcatcgc ttccctgacc gttttcacct ttttgcgtgc ccaatgcgaa gcgatttttt 2427541 ggatatagtt tttcgacagc ttcatgtcgg ttttcagcat gacataataa attaacacat 2427601 ttgtgacgcc tggctcgagc ttctgttcga acataatttc ttctatgatc ttcagatcag 2427661 cttttgacgg ctctgttccg tcagcaatgt cctgcagaag cttcttcggg gaaatcgcct 2427721 ccagcaatgc aatcagcttc ccatccagag aatcctcttc tgccggttgt tcgccttcac 2427781 gcagatgcac cggctgtgtt ttttccacca aatcgggcag ctgtccgttt ctttcaattt 2427841 gataccagtc gctcgccgct tttcttaatg cctccgtcgt aatgacgtca cgctcatcaa 2427901 ttgcgctcat cacaacattt tgcatttgca aagggtcaat tccgtacaga taagaaagct 2427961 ttttgattgt gtcccgcacc tgctgggtca tcgcttttct cggtatcatc gtctcagaaa 2428021 gtcccgctaa aaacaaatca aaatcaaaca catcctccgt tatggtgtag gacggagact 2428081 gtccgacaga agtatactcg gacccctcgg caagccttac cgtttcctcc atatcggatg 2428141 tgagcttcca ttcactcggc tgcagcgatt caaacgcatg attaaacgga cgcgtaatgt 2428201 ccttcgcatc ttctgaaatg gccgggtgcg taaaaaattg ttttaattgc tgatatttcg 2428261 tttttccgac cctattatac agaaaaacat tcagcattcc gtcttcaaaa aattcatttg 2428321 gtctgagcgg cggaaggagt tcatatataa agaggcgctc ctgccgctcg gattctttca 2428381 tatatacttt cagcaatccg atgccctcga gcttcccctg ttcctgatgg atcgttttta 2428441 agttggactg tgtcatcccc atcagctgtc tatgtgtgga ctctccgccc cacagacggt 2428501 tttgttcaag ctctccccac aatgtcatat aaagagagaa tgcaacaggg ccgattaagg 2428561 gctggtacag ttgtgtaata atttgtctgt caatatcctg cagcatcgat ctgcttttaa 2428621 ccacatacgg gtctacaggc agtacatctt tccaatagtc agccatacat tctcaaacct 2428681 tccgaatttg tttctacctt tcattttaca ccgtttctta tatctatcaa atgccaattt 2428741 tgcacatgag aaaagagcta gaagaatcct cttagctctt ttaacgctct ttctttatta 2428801 agtcttttaa ttcatcgata aagacgttta tatctttaaa ctgccgatag acggacgcga 2428861 accgcacata tgcgacttcg tcaatcttag ccagccggtc catgaccatt tctccgacga 2428921 gctcactctt cacctcggag cagccttgat tgcgaagttc tttttcaata tcaaagcaca 2428981 tgtcttcaag cgttttgagt gaaacaggcc ttttttcaca tgcttttatg aggccgcgca 2429041 gcattttttc tctgctgaat tcctcacgca caccttcttt tttcacaacg atgagcgggg 2429101 tttcctccac tttctcaaag gtcgtaaacc ggtagtggca ggattcgcac tcgcgtcttc 2429161 ggcgaatcga ctttccgtca tccacaggcc gtgaatcaag gactcgtgtt ccgttatgct 2429221 ggcatgaagg acatttcaat aaaatcagct cccaactata tcgttccctg caatgtattt 2429281 tcggcagcct ccgcctttta aaaatagatg tgacagcatc tgtcgggaga gccgttgtta 2429341 aatttgtttc tatagcatta ggtggtttgt gaaaatctcc ttcttatttt acaaaaaaaa 2429401 tgaaaaaaga aaaagctgac actctcgttt ctttataaaa ataaaaggag cataagctaa 2429461 aaagcgcata atggctttct agcttcagct ccctttgtgt tcgcaattta ctttatagta 2429521 ctttcgcttg cgcctgttta atttgcacag gccccattcc tcttggtatt tcaatgtttt 2429581 ctcttgtatc agcatgtaat gcctctgcaa tgtaatcagc agcgacatta ggatctaagt 2429641 ctccacaagt ataaacatca atgctcgcat atccgtgctc aggaaaactg tgaatcgtta 2429701 agtgtgattc agaaataatc acaactccgc ttacgccttg cggtgcaaat ttgtgaaatg 2429761 caacctcgcg cacctcagca cctgatttta gagcagcatt tacaaacgtt ttttcaataa 2429821 aatccatgtc attcagctta tcaaaatcgc atccccatag ctcggagata acgtgacgcc 2429881 ccattgtttc catagtcatg gacccccctt aacaagaatt aaaaagtgaa attccaacaa 2429941 ctgggtcggc catttaccac gggggaaagt tagtccggag aggtcctaac cctttaagta 2430001 attccgaaac agtctcaagc aagaagttca cgaaaaatag tatactgtgt ttaagtctaa 2430061 tttgcaaggt gcgttttttc agaaatatgc tgttaagggt tttttcttta aaatgtgtcc 2430121 atgaccttat tttatacagc agacggatgt ttcattcgtg ccgctacatg gcggattaga 2430181 tcaacaactc tgcaggagta gccccattcg ttgtcatacc acgccagcac ctttactttc 2430241 ctgtcttcca ttaccattgt tgtaagcccg tcaatgaccg ctgaatgcgg attcgtatta 2430301 taatcagtcg aaacgagcgg ttcatctgag taatcaagta caccgtacat cgacgttttg 2430361 gcagcgcgtt taaatgcctc gtttacttct tcagccgtaa catccgtttt cagatcaaca 2430421 acgagatcaa ccaatgagac gttcggaaca gggacacgca aggcgaggcc gtgaagtttt 2430481 cctttcagat gcggcagcac aagcgaaagc gcctttgccg ctcctgttgt tgttggaatg 2430541 atggattcac cgcaagcccg cgcccggcgc aaatctttgt gcgggttatc aatatttttt 2430601 tggtcattcg tatacgcatg aactgtagtc atcagaccgc tctcaatgcc aaactcttca 2430661 tccagcactt ttacaacagg cgcaaggcaa tttgtcgtgc atgacgcatt tgaaataatg 2430721 acatggcgct cagcgtcgaa ttggtcctca tttacgccca tcacaatggt aacgtcttca 2430781 ttttttcccg gagcggtcaa aatcactttt tttgcacctg cttctatatg gcccatcgct 2430841 ttatctttag cattaaactt ccctgttgct tcgacgacta tgtcaatatc atattcccgc 2430901 caaggcagct gttttggatc acggctgttt aacaaaagca ctttctttcc atttacgatc 2430961 aggctatctt caccagccac aacctctttg tcgtatctgc cgtgaattgt gtcatacttt 2431021 attaaatgag ccagcgtttc tgcggaatag ctggcgttaa tggccactac ttgaatttga 2431081 tcgtctaaca tcgcttttct aaaaaccatt cttccgattc ttccaaaccc gttgatcgct 2431141 acttttacct tcatgttgga caccccttat caattatgcc atcctaattt gttactatct 2431201 aaaattagta taacacatta aaacaaattc gccagtacat attgataaaa atcaacgatt 2431261 ataacgctaa tttatgatgc atcttatgtt ttcttgcaca gaatatcagg cgtaagaacc 2431321 aaaaagcagc cagcgctccg cactgactgc cctcatgctt tatgattcct gttttaactt 2431381 atcattgagc acactttctt ctagcacaga aaatgtatcc ccgtacactc tgttaatatg 2431441 attcgctccc caagcacaca gcatatctaa aatcccttct aagctgcggc cgtattcgct 2431501 gagctcgtat tccactttgg gaggaacttg attatatacg attcggttaa tgacaccgtc 2431561 cgcttccagc tcgcgcagct gctgagtcag cattttttgc gtgatattgg gcattaggcg 2431621 ttttaattca cttgtgcgtt tttttccgtg cgtcagatgg cataaaatga cgcatttcca 2431681 tttcccaccg atcacttcaa gagtcgcttc aacagaaatg ttatattttt tcttctccat 2431741 acaatccatt ctcctcacag gcaccaaaaa gtgactatag cacttcaaag tacgtacttt 2431801 tatttcttaa cgatatgttt cataatcaca tttgccggct gatttgaatc tgctcttttt 2431861 tatttatata gcttactcgg cagaatttca atcatacaac acatcttaca aaggaggaac 2431921 atcatgactt cagccaataa aagcaatatt cctgcactac tggctttggc cgtaagtgca 2431981 ttcgcaatag ggacaactga atttatcagt gtcggccttt tgccgctcat tgctgatgac 2432041 ctggatattc ccgtcacgac agcaggattg accgtttccc tttatgcgct cggcgttaca 2432101 tttggggcac ctatattaac ttcattgacc tcaagcatgt cacgtaagac actattgctt 2432161 tggatcatgt ttatttttat tgccggtaat acgatggcag caaccgcttc aagcatcggg 2432221 attttactag cagcacgtgt gatatcggca ttttcgcacg gtgtgtttat gtcgatcggt 2432281 tcgacaatcg cagcggatat tgtcccggag gataaaaggg ctagcgcgat ttcaattatg 2432341 tttactggcc tcactgtggc aactgtaacc ggagttcctt ttgggacatt tatcggccag 2432401 cagttcggct ggcgtttcgc ctttatggtc attatcgccg tcggaatcat tgctttcatt 2432461 acaaatggca ttcttgtacc gtccaaatta cgaaaaggga cgaaaacaac gatgcgggat 2432521 caattgaagc ttgtgacaaa cagccggtta ttgcttttat ttgtcattac agcgcttgga 2432581 tacggaggaa cattcgttgt gttcacgtat ctgtctcccc tgcttcagga agtaacaggc 2432641 ttcaaagccg ggactgttgc agtgattctg ctcggatacg gaatagctat tgctatcggc 2432701 aatatgattg gcggaaagct gtcaaaccga aatccgattg ccgctttatt ctatatgttt 2432761 atcgtacagg caatcgttct attcgtactg acatttacag ccccgtatca agcagcaggg 2432821 ctcattacca ttctctgtat gggattgctg gcctttatga acgtgcccgg ccttcaggtg 2432881 tatgtcgtca tgctggctga gcgttttgtc ccgagtgcag ttgacgtcgc atccgcgatg 2432941 aatatcgctg cctttaatgc agggatcgcg cttgggtcat accttggcgg tgtgatcacc 2433001 gattcaatcg gattgattca taccgcttgg ataggcggat taatggtggt cggtgcagtc 2433061 attttaacag gctggagccg cttgatggaa aaacgagatc ggcaggaagc ctgacaattt 2433121 taaaggagga aataaacatg acaacacatt tacaagcaaa agcaacactt cataatgggg 2433181 tagaaatgcc ttggttcggc ctcggcgtgt tccaagtgga agaaggatct gaactggtaa 2433241 acgcagttaa aactgccatt gttcacgggt accgcagtat tgatactgca gcaatctatg 2433301 gaaatgaagc tggagtcgga gaagggattc gggaaggcat tgaagaagca ggcatttcaa 2433361 gagaggatct gtttatcaca tcgaaagtat ggaatgcgga tttaggctac gaagaaacac 2433421 tcgccgcgtt tgaaacaagt ctgtccaaac tcggtctgga ttatttggat ctatacctca 2433481 tccactggcc tgtagaagga aagtataaag aagcttggag agcgcttgaa acgctgtata 2433541 aagaaggccg tatcaaagcg attggcgtaa gcaacttcca aattcaccat cttgaagatc 2433601 tgatgacggc agctgaaatt aagcctatga ttaaccaagt ggaatttcac ccgcgcctca 2433661 cacaaaaaga gttgataaga tactgccaaa atcagggcat ccagatggag gcttggtcac 2433721 ctttaatgca gggacagctg ctggatcacc ctgtattggc tgacatcgct caaacatata 2433781 ataaatctgt cgcacaaatt attttgcgct gggatctgca gcatggcatt ataacgattc 2433841 ctaaatcaac gaaggaacac cgcattaaag aaaatgcaag cgtatttgac tttgaattaa 2433901 cgcaggatga catgaaccga atcgatgcac tgaatgaaaa cttgcgcgtc ggtcctgatc 2433961 cggacaactt tgatttttaa tggccaaaaa acaccgttca atatgaacgg tgttttttgt 2434021 attatgccca gctgttcatg atttcatcaa gctgcctttt ggtctcttca agcgtgccgc 2434081 tgttatcaat gacttgatct gctcttgctg ttttttcctc taagggcatt tgagagcgga 2434141 tacggctgac tgcttcttct tctgtcagct gattgcgctt catcagacgt tccagttgaa 2434201 gctcttttgt cacactgacc acaataattt tatcaaccaa tgattccaat ttgctttcga 2434261 acaatagcgg gatatccaat acaacaaatg cctcccgatt tgcaacggct tcatcacggc 2434321 gattgagcat ttcctgcctg actgcgggat gaacaattgc atttaaagcg agacgttttt 2434381 gttcatttgt aaataccagc gctccaagct tttttctatc tatatcgcca tttgagagca 2434441 gtatgtcttc accgaattcg tcaatgattt gccggtaggc cggcatccct ttttctaccg 2434501 cttgttttgc aatgatatct gcatctataa ctgttattcc tttttcaatc agcatattgg 2434561 ctaccgtgct tttgccgcta gctattcctc ccgttaaacc aatgactaag gtcaagagat 2434621 ccactccttt ttacaatttc cagagcccaa tcgtgattaa tagaagcccc ggcaaaaacg 2434681 ccattttatc gatccatttc cacttagaca gaaaatggcc ggcattgatt ccaattgata 2434741 caaacagcga gctcatgatt gccacggcga tgctcatcac aatcggcgaa aaaccgagaa 2434801 tggctgcgcc tatacctgct ccaaaggcat caatcgataa ggcaaatccc aataagaccg 2434861 cctcaattcc gttgatcaca cccgatttgt cgatatccgc actcatgggt tttctcaaaa 2434921 tatgaatcac aattcctaat gaccgaacct ctagattaag cagtgttttt tcatgcaata 2434981 ggtattcttt atcttttgcc ggtttgaaaa attgatacag aacccacgca ccgattccaa 2435041 ccaatatcaa accgccaagc ttctccgtca catatacagg aaaaaacttc gtgagaaagc 2435101 ttccgatcag catggatata aacatgacag caccggaaca gcaggcgata accaaaatcg 2435161 ctttaaacgg tattttcatt tttctcaatc cgtacgtaaa tccgactgaa aaactgtcca 2435221 agctgacagc caacgccagc agcagtatag aaaccatttg catatccgtt tcttcctttc 2435281 tgttggtgct cttgtatcag atgtgaaatg cccgggattc atcacaatca tatatatggg 2435341 aaagtgaaaa atccgtgttt cgaaaatggc atccttaatc cagagttact gatatatgca 2435401 ccgacagctt ggacaatgaa gcattatgct acttttttgt ctggcacttt gcgcaaaaat 2435461 gcgtgcctct tcctccaacg acaattttcg aaatcatcgt tccgcaattt ttgcatggct 2435521 cgtctttttt tccgtacaca aaatgctgca gctggaacat tccgatttcc ccttgggagt 2435581 tgatatatga acggactgtg cttccgcccg catcaatcgc ctcctgcaga gtgtttttga 2435641 tttcagcgtg aagggttttg attgttttat ctgataattg atttgctttt gtctcgggat 2435701 ggacacccgc tctgaaaaga gcctcatcca cataaatgtt cccgagtcca actaccgttt 2435761 tttgatccag tagggcagtt ttgacagcgc ggtttgtttt cgcaagccgg tcttttaaat 2435821 acgcacttgt aaattcttct gcatccggct ccggccctaa ctgagaaagc gggagctcgc 2435881 ccgcttcttc tcccggttta aataagtgca tggttccaaa tttccgcaca tccctgtacc 2435941 ggagctgggt tccatccgtc atcgtgaata tgacatgcac gtgtttatcg tcaggctcct 2436001 cggcttgatg aagaccgtat tttccttcca ttcgaaggtg agaaaccata acataatgat 2436061 ctaaatgaaa cagtaaaaac tttccccgtc ttccgatgga ctgtatcgtt tctcctgcta 2436121 gttttcgcgc aaattcctcc ggttcggcag gccgtttgat gatattcggc catctgatct 2436181 ctaccgattt gattgttttt ccctttacaa gcccggtcag agtgcgccgg accgtctcaa 2436241 cctctggtaa ttccggcaca tccatcactt cctatctctg tttatttcgc atcgtaccaa 2436301 gatgggcctg atgcaaagtc cacctttaac ggcacatcta atgcaagcgc atgctccatc 2436361 acttcaggaa caagcttttc aagaatttca atttcttcct ttggcgcctc aaaaatcaat 2436421 tcatcgtgta cttgaagcag aagccttgct ttcaactgtt tttctttcag cttggcagcc 2436481 atgtcaatca tggctttttt gataatatca gcggcgcttc cttgaatcgg cgtattcatg 2436541 gccgtccgct ccgcaaaact tcggatatta aagttccggc tcgtcagctc agggatgtag 2436601 cggcggcgat gcataagcgt tgttacgtat cctttttgtt tcgcttcctg tactgaatct 2436661 tccatgtacg cttttacgcc ttggaagctt tccagatagc ggtcgataaa tgctcccgct 2436721 tccttccggg taatgccgag gttctgtgac agaccgtaat cgctgatccc gtaaacaatg 2436781 ccaaagttga ccgctttcgc ctggcgtctc atcgcagatg tcacttcatc cttagcgaca 2436841 tggaacacat ccattgccgt tttcgtgtga atatccatat cattagtaaa agcttcgatc 2436901 agattttcat cctttgaaat atgggcaagc acccgcagct cgatttgtga ataatcggct 2436961 gcaaaaatga gccagtcttt ttcagacggc acaaaagctt ggcgaatttt ccgcccttcc 2437021 tcaagcctga tcggaatgtt ttgcaggttc ggatcagtcg agctgagacg gccagtttgc 2437081 gttaaggcct ggttaaatcg cgtgtgcact ttatgcgaat ccggtctcgt cacctttaaa 2437141 agcccttcga tatatgttga ttgaagcttg ccaatttgtc tgtactgtaa aatatagtcg 2437201 acaatatcat gcttgtcagc cagcttttca agcacatcgg cagacgtaga atagcctgtt 2437261 ttcgttttct ttacgacagg aaggccgatc ttttcaaata agatgacgcc tagctgtttc 2437321 ggagaattga tgttaaacgg ctctcccgca atctcatgga ttttttcttc atattccttc 2437381 agcttcgcac ccagttcttc acccatccgt tttaaacggt caacatcgac cttgacgcca 2437441 gttgattcca tttcgccaag aataagcgca agaggcattt ccagctcttc aaacagttca 2437501 agctggtcgt tgttttccag ctcttgaacg agcttttccc gaaggctttg aatcgctaac 2437561 gcttttcggc caaggtgctc agacagtacg tcttctgacg gcactgcccg ttttgctcct 2437621 tttccataaa ctgattcatc acttgaaacg atatgcaggc cgtaatcctt agccacactc 2437681 gcaacgtcgt catatgaatt gcccgggttg atgatataag ccgcaaggag cgtatcaaac 2437741 tcggctcctt tcagctcaat gccctgccag cgcaaagcga caacggcccg cttgctgtcg 2437801 aagacccatt tcttctgctc gtcattttcc acccattctt taaacacctc agactcaacg 2437861 gcaatgtctt tcggaatgaa ataagctccc gtttcattta cgatcgaaaa tccgaggatc 2437921 ggctcttcat gataattatc gccaatctgt tcaacgacaa atgcggatgg agaaaccaat 2437981 atatcgcttg tcacgtctgt gactgttttg acattaatgt cttccaacga ttgatcctgt 2438041 tctgcttctg cactgtcttc tccaagccgt tcaagaagcg tgttgaagcc aagatcttta 2438101 aagatggcaa tgacctgttc acgattaaag ccttgatatt ccaggccgga aacagatacc 2438161 tcaatcggag catccgtcat aattgtcgca agctccttgc tcatcaatgc ctgatcctta 2438221 aactcctcaa gcttttcctt caatttcttt ccgctcacct cgtcaatgga ctccagcagc 2438281 ttttcaacgg aatcaaattg ttttaaaagc ttaatcgcag tcttttctcc gacgccgggc 2438341 acacccggaa tattatctga ggaatcgccc atcagaccct tcatgtcaat gatttgttca 2438401 ggcgtaagcc catatttctc tttgacatgc tccggtgtgt aaaattcaac atcggtaatt 2438461 ccctttctcg taatggcaac tgtcgttttg tccgttgcca gctgggttaa atccttatct 2438521 cctgagaaaa ccttaacttc aaatccgtct ttttcagccg atttggccag tgtgccgata 2438581 atatcatccg cttcatattg ttccagttca tagcggctga tctggtaggc atccagcagc 2438641 tcgcggataa acggcatttg ttcggaaagc tcaggcgggg ttttctgtct gccgccttta 2438701 tattctttaa atgtgccgtg acgaaatgtt gttttcccgg catcaaacgc aaccagcatg 2438761 tgcgtcggtt tttcatcctc aagcattttc atcaaaatca tcgcaaagcc gtatacagca 2438821 ttcgtatgaa cacctttatc attgcttaac agcggcaatg caaaaaacgc ccggtaagcc 2438881 agactgtttc cgtctacaag cactaatttt tttcgttccg tcattcaatt tcctcctaag 2438941 aagcctcagg cttccattca tctcttacat agtcattagc tcctcttatt ttaacaaagt 2439001 tcaatttgaa aggaaaatac gtgaactata agagaagaca caaaaaagga cgggaacaca 2439061 aataggttcc cgccgtcaaa attggctcct tggatgaagg ggttctacta catcctacca 2439121 gcataggttt aacagtgcat gaagatattg ttaaaccttt gtaaacatta ggcggacttt 2439181 tcagcggccc gtttcagcgt cacggtaaag acagttcccc gtccaagctc gcttgtgaca 2439241 tcaattttcc cttcatgagc ctctattaaa tgcttgacaa tcgctaggcc cagcccggtt 2439301 ccgcccgaat ttctgcttct gtctttatct acacggtaaa agcgttcaaa gatgcgcgga 2439361 atttcttctt tctgaattcc gattccagaa tcggcaacct caatctgaat gtctttttct 2439421 ctgggcttta cattgatagc cacggagccc ccctcaggcg tgtaggttaa tgcattgttt 2439481 acgagattaa gaaatacctg tttcagcctg tacgggtcac cagatacata ttgagggtct 2439541 ttcgggacat tcaggtgcaa ggagatgcct ttctcatccg ccttatgctt cagaagcgtt 2439601 tcaatctcac caagcatttt ggccggctca aacgtttcga tactgagcgt gaaattttgc 2439661 tgctcgattt ttgagagatc gagcaaatcc tgaaccaaag actgaagcct ttcgctttcc 2439721 ttaagaataa tagagagaaa ttcagaaagc gcctctttgt cttccatcgc cccgtccaat 2439781 aacgtctccg taaacccttt tatggacgta atcggtgttt tcagctcatg agaaacattg 2439841 gccacaaaat ccttcctcat ctgctctaat ttcttcgttt ccgtcatgtc atggaaaacg 2439901 agcacaattc ctttccattc atcgtccggc cccataatcg gaacgccgtc cacttcaaaa 2439961 taacgccgtt ctattttgat cggcagtctt aacagcttgc atttctttgt ctccgtcata 2440021 aaaatgtctt cgacaagctg gatcacttct tcatgttcaa atgcatcgtg ataaagacgg 2440081 cgcagcatat gattcggatt gatatgaaac tgcttggcgt aagacctgtt tacgagatta 2440141 ataaagcctc ttccgtcgat cataatcagc ccggagccaa tgttttcaat gactgtcagc 2440201 agccgatccc gctgcatttc ctgcgttcgc gtcatttcca tcagatcaat ggcaaggctg 2440261 ttcatcgcat gtcctagctt atcagaacgc ctaatatagc cgccgtacgt ccgtgcatcg 2440321 tagttgccct tagagagttc tgtggctaca tttgtcgctg actcaattga ccttttataa 2440381 cgtgaggtca tgctggaata aaaataaaca atgacgataa atgcggtaca aagactggcc 2440441 gtcagcatcc cccacaattc gccttttaag ccgtcgcttt tttcagaggc ggaaagcagc 2440501 acatatcctg ttttttcacc ttcgcttcta agtgaaagtc cgtaataaag cttgttatct 2440561 gttgttgaca gaataccctc atggccagaa acaagcgcct gcaccttttg ggaatcagcc 2440621 gatctaccgt ttgacccata cagcacctta ccgtctgtat cgataacgga tgcgctcaca 2440681 tcaagcgcgc cgcctgcatc tttaatgatt ttctcatttg cttgattatt cagattgccg 2440741 gcatcaagaa gcgaagccaa gtattttgct tctttttcaa tgtgttcctc tgctttcctt 2440801 tgatcagatg tttcaaaaag ctgctgtaaa aacagcccga ggacacaaaa caccagaatc 2440861 atacagacaa cgaatacaga aaaaaggcgc acacggtatt tattcattca tttttggctc 2440921 ctccagttta taccccaatc ccctaatcgt tttaatgtag atcggttttt tggtattgtt 2440981 ttcaattttg tcgcgaagat ggctgatgtg cacatcaaca attctcgtat ctccggcaaa 2441041 atcataattc cagactgcgc tcagcagcag gtctcttgtc agaactctgc ctttatgtct 2441101 gcctaaatag agcagcagtt cgaattcttt cggtgtcagt tcaagctgac tttctttaaa 2441161 gtacgcttca taatgatcag gcaggatttt cagatcgccg attacgatct ggccttccat 2441221 ttcatcgttc ttcatctcac tagagggcgc agctatttcc gaacgcctta aaatcgcttt 2441281 gactctcgca tttacttccc ttggactgaa cggcttggtc atataatcat cagcaccgag 2441341 ctccagccct aatactttgt cgaattcctc atccttcgct gtcagcatta aaatgggaaa 2441401 catcagtttt tgctgtctca gctgcttgca tacttcgatt ccgtccaatt ttggaagcat 2441461 cacatcaagc acaatcaaat caggtttctc tgtttccgct tttttgagtg cttcttcccc 2441521 atccgaggcg gtaatgacat catagcctga ccgttccaaa ttgtactgta aaagagtaac 2441581 aatagattct tcatcatcca caactaaaat tttcttgttc atgctgtgcc tccagtatta 2441641 taattccccg acatcctatt tctctatttt atgtcatctt aacatgtttc atgattttat 2441701 tttagcgaaa gcaggacatt ccgacaattc gccttttaca tcatttttaa aagaaataaa 2441761 gacgtttatg atagcgcttt catttatagt aaaaagagaa aggctgtatt aagcaagcct 2441821 ttctctcttt ttattaggat aatactttca tgacattttt gacagattca actgatttat 2441881 tcagctgcgc tctttcatag tctgtcagtt caagttcaat gatttgctca agaccgttgc 2441941 cgcctacaat tgtaggaaca ccaaggtaga tgccttcata gccgtattcc ccttcaagat 2442001 aagcaattgt aggaaggacg cggcgctgat ctttcaagat cgcttcgacc atttctgtca 2442061 gagaagccgc aggcgcataa tacgcgcttc cgtttccaag aagattcacg atttcgcctc 2442121 cgccttttct agtgcgctcc acaattgcgt caatccgttc tttcggaata agagtttcaa 2442181 gcgggatacc gccagcataa gaataacgca caagcggaac catatcgtca ccgtgtccgc 2442241 cgagtacgaa accagtcaca tctttcactg acaggtttaa ttcctctgcc acaaatgttc 2442301 tgaatcttgc cgtatcaagc acacctgact ggccgattac acgctcttta gggaagcctg 2442361 attctttgta caccgcgtat gtcattgcat caacaggatt tgtcagcacc acaataatag 2442421 agtcaggaga atatttcacg atttcctgcg taacgcttct cataatcttt tcgtttgtag 2442481 agaccagatc atctctgctc ataccaggtt ttcttgcgat accggctgta atgacaacaa 2442541 tgtcagagcc ggctgtatcc tcgtaattgg atgttcccgt aatttttgcg tcaaagcctt 2442601 gaaccgggct tgcttcaagc atatcaagcg cttttccctt tgtcgggttc tccaattgcg 2442661 gaatgtcaac aagaacaacg tctgccagct ctttttgagc gattaaaaat gcagttgtag 2442721 ctccggtaaa acctgctccg ataacagaaa cttttttacg agtatttccc atgtctctct 2442781 tctcctttat ggctagtttt aggctttttc cttgcttagt ccatgttttt gatcagttct 2442841 tctccgaact ctgaacattt cacttcagtc gccccgtcca ttaatctggc aaaatcgtaa 2442901 gttacgactt tagaagcgat tgttttttcc atagatttga taaccaaatc agccgcttcg 2442961 ttccatccta aatgctcaag aagcagaacg cctgaaagaa taactgaaga tgggtttact 2443021 ttatcaaggc ctgcatattt aggagccgtt ccgtgcgtcg cctcgaaaat cgcatgtcct 2443081 gtttcgtagt tgatgttcgc tccaggagca atgccgattc cgccgacttg cgcagcaaga 2443141 gcatcagaaa tgtaatctcc gttcaagttc attgtcgcaa cgacatcaaa ctcgtttgga 2443201 cgcgttaaga tctgctgaag gaaaatgtca gcaatgctgt ctttgataat gatttttcct 2443261 gctgcttccg cttcgctttg cgctttgttg gcagcgtctt ttccttgttc ttcagcaatg 2443321 cggtcatatt gagcccatgt gaagacttta tctccgtatt ctttttcagc aagttcatag 2443381 ccccagtttt tgaaggcgcc ttctgtgaac ttcatgatgt ttcctttgtg aacaagtgtt 2443441 acagatttgc ggccatgctc gatcgcataa tcaatggcag ctctgaccaa gcggcttgtt 2443501 ccttcttctg aaacaggctt aatgccgata cctgatgtct cagggaaacg gattttattg 2443561 acgtttaact cattttgaag gaagctgata agcttttgca cttcttcaga gccttttgca 2443621 tactcgatgc ctgcgtaaat atcttctgta ttttcacgga agatgaccat atcagtatct 2443681 tcagggcgtt ttaccggtga cggcactcca gtaaagtatc ttacaggtct taagcagacg 2443741 aataggtcaa gctcttgtct gagcgctacg ttcaaagaac ggataccgcc gccgacaggt 2443801 gtcgttaacg ggcctttaat cgcgatgaaa tattcgcgga tcacatctaa tgtttcagca 2443861 gggagccact cacctgtttt attataagcc ttttctccgg cgtaaacttc tttccatgta 2443921 attttctttt cgcctttgta tgctttttct actgctgctt ccaaaacctt cgaagccgcg 2443981 ttccaaatat caggaccggt tccgtctcct tcgataaatg ggataatcgg gttgtttggt 2444041 acgtttaata ctccgttaga gactgtaatt ttttcacctt gtgccacaat aaaaacctcc 2444101 cagtatgtaa ttcatattta gaaaacattt tatttttctt atatagaaaa taaaatgatt 2444161 tttcctaaca ttcaatttaa agtgtaaccc aattttgatg tctgaacaag aggctaacct 2444221 cattgacgca agccagcctc caatggttct ttaggctctt tcttcaatcg gaacgaattt 2444281 ttgtttgtca gggcctgtgt aatctgcccg cgggcggatc agacggttgt tgtcatactg 2444341 ctcaagaata tgagcgagcc agccggacat tctgcttaca gcaaaaatcg gtgtaaacaa 2444401 atcatggtca ataccgaggc tgtgatatac agaagccgaa tagaaatcaa cgttaggcgg 2444461 aagctttttc tctgatgtga cgatgtcttc tatacgaatc gacatctcat accatttgct 2444521 ttcgcctgtc aggttggtca ggcgcttgct catttctttc agatgcttcg cgcgcggatc 2444581 accatgctta tacacacggt ggccgaatcc catgattttt tctttctttt caagtttagc 2444641 gcggatgtac ggctcagcgt tttccacttc accgatttct gtcagcattt tcataacgcc 2444701 ttcattcgct ccgccgtgaa gaggcccttt cagcgcgccg attgctgcag taatgcctga 2444761 atagatgtca gaaagtgttg cgacgcagac cctcgctgtg aacgttgacg cgttcagctc 2444821 atggtcagca tgtaaaatca atgctttgtt gaaggcttca acttcaattg gtgaaggctc 2444881 ttcaccgttt aatgtgtaaa gaaaattctc cgcaataccg taatcttctc tcggttcaac 2444941 aggctcaaga cccttgcgaa ttctggaaaa cgctgcaacc aggccaggca cctttgcctg 2445001 aaggcggatc gcctttctgt agttggcttc cgggttcatg gtatcagcct cgctgtcaag 2445061 caggcctagt aatgaaattg ctgtccgaag agcagccatg ggatgaacat tttcgaggga 2445121 ataagatttg aagtgctcaa taatttcttg cggaacggca gcttcctttg caagctgctg 2445181 ctttaactct tcaagctctt ttttgtttgg cagccttaga tgccaaagca agtagatgat 2445241 ttcttcaaaa cttgcattct ctgtcaaatc atcgatatca taccccacat atgtaagggt 2445301 atcatcaata atagaactaa cagatgatgt tgttgctaca accccttcaa gaccgcgtgt 2445361 cgctgtcata tataacatct ccttttcaat aaatttcccc tttaagagtg ttgtaaaaac 2445421 atgaggctta cttaaaaagc acgatgcaag tatttctctc ccccaaaaag aaaatgctta 2445481 cattttactg gctgctggaa ctaaaaccct ttgcttttga aagaacataa caaattttta 2445541 taagcttatt taagtttaag cctattctca ttataaacaa taatcagaca tttgttaaat 2445601 gtttacctat aatttttttt ttccattctg tgatttcccc gaaaaaacgc ctttatttgc 2445661 gggtttttgc ataaaaaaaa gcggctttaa ggccgctttt ttttatgaag tgaacagttt 2445721 tacgatctgc atggctaaat aagcaatccc cgctccgatc agcggcccca ccgcaactcc 2445781 tccaaaaagc gcgactgcaa gaatggtccc gatcacgaga gcagttgtaa tatgcggatc 2445841 attttcaagc agggtcaggc cgttttttgc aatcagcgcc actgcgatcc ccgctccaag 2445901 ggcgatccat gcgtaggaag accgcattgc ttctccaagc tgcttaaatc cgatttctcc 2445961 cgtggcaatc gggacaagaa cggcgatggt aataatggtc acaccccagt taatgccttt 2446021 tgactggatg gtcggaaata atttctgatc aagcccaacg attttgatga tcaaaaggac 2446081 ggatacagca aagagcaatg attggttttt tgcgataagt gcgatagcca agagtaaaat 2446141 taaaaataaa ttcgcttgtg taaacacatg ccatccctcc tttaagatga atgtattcat 2446201 attcagccgc agcgtgaata catataaaaa ataggacatg ctgacgagag gaggaccgtt 2446261 tttgtgaatc aatcttatat cactattttt ttcagaaccc tctttgtcat atcaatgacc 2446321 gcagggtcga tagctgcggc ctattattcg tttccgttaa cttatccgtt cctgatcgcc 2446381 cttattctat cttcagtgat tcatcctgtt gtcgattatt tggacaaagt gacaggattc 2446441 ccccgaacga taaatgttct gggcgttctt gctttttttc tgctcgcagc cttcggcgtg 2446501 ctcaccattc tggtagccga aatcgtaacg ggaacagcct atctagcaaa aacgctgcct 2446561 ccgcatatca gcacgtttat ttcatattgc gaaaaattgt ttaccactca tattcagccg 2446621 ctctataacg agttaactct tttgtttcaa gaattggaaa cgaaccagca ggcttccatc 2446681 gtcactcata tccagacact cggtgattct gccgctaaaa atgccgggct cctgctgtcc 2446741 cacattctag agatgatccc gagatttttc gctcttcttc ccaatacggc ggcggttctg 2446801 attttttctc ttctggcaac cttttttatg acaaaggatt ggcataagct gaaagccatg 2446861 cttgttttaa ttctgccgga tcgtgtgaca gctaacagca aagcaatcag cagcgaatta 2446921 aaaaaagcaa tgactggttt tatcaaagca caagccgtcc tcgttttcat cacgatggtg 2446981 attgtattta tcggcctttc tctcttaaag gttgaacacg ccgcaacaat tgctttttta 2447041 atcgggcttg tagatcttct cccttactta ggtgccggct ccgtatttgt gccctggatt 2447101 ttgtatttat cgattacggg ccagctgccc caagcaatcg gaattggtat cctgtacctc 2447161 gtcgttctta ttcagcggca gctgacagag cccaagatac taagtaaatc tatcgggatc 2447221 gatccgctgg caacactcat cgccctgttt gccggcttta aattattcgg gtttttagga 2447281 ctgattgcgg gaccggctgt actcgtcatc atccaagctt tcatcacaac aggcgcatta 2447341 aaagaaatat ggtcctatat caccgttcag caaaaataaa acggcagccg ttttttcatg 2447401 gctgccgttt tttatttgat gatgatccgc ttattcttcg acattcctct cagccatttg 2447461 aacagaatcg gcttacacca gccgcgggta aacgggataa gaagacaggc gccggccaaa 2447521 tctgataaaa agcccggaag catcagcaat agaccgccaa tgaaaatgca cagaccgtca 2447581 gcaatcgctt ctcccggcat tttgccatat tgaagatcac gctgaacctt ataatacact 2447641 tcggttcctt gtttttttgc agctgctgcg ccgataatgc cagtcagaat catgaataga 2447701 actgtcggca aaataccaat cagatttcct aaaaatagga atataccgat ttctattgcc 2447761 ggaaacacaa taaaaagcaa aaacaaaaat ctcatatcca agccccccac acgtgtaaca 2447821 cgttctgttc aacaaaaggc atgataaaga gaaaaggaag ggattcccct tccattttca 2447881 cctgtaatta aagaacgctc gcacggcctt gatagactgc gcctctggaa gcgtcaactg 2447941 taatatcctg gccatctgtc aaaatagatg tcgcattttc cagacccacg ataaccggga 2448001 tgccaaggct taatccgact accgcagcat ggctagtcaa accgccttct tctgtaataa 2448061 gagcagacgc tttttcaagg gatgcaatca tatcacggtc agtgcttttg gtaacaagta 2448121 ccgcaccgtc agtcattttt tgctcagctt cttttgcatt ttgtgcaacg acaaccggac 2448181 cgtaagctga tttgcgtcca atgccttggc ctttagcgat gatatcgccg acagtatgaa 2448241 ccttcattaa gttcgtagtg ccggactcac cgacagtgcc agctgtaata acgataagat 2448301 cgccgtgttt tacaattccg ctgttcaatg atttttggac agcatcctca agcatctcat 2448361 ctgttgagct cgcattttgg ccgctttccg cgaatacgcc agatacgagg gcaagctttc 2448421 tggaaataga gtcatttaca gtaaccgcaa caatcggagc ctgcggacgg tattttgcaa 2448481 tcatacgtgc tgtatggccg ctttctgtcg gcgttacgat cgcagcagca ttcaggttaa 2448541 tcgccgtatg tgcgacagat tgtccaattg cgtctgtaat tgtcatgccc acttggtctc 2448601 tgcgttttga gagaatttct ttataattta atgcttcttc agaacgggac gcgatgttat 2448661 gcattgtttg aactgcttca accgggtaac ttccggcagc agtttcacca gaaagcatga 2448721 tcgcatctgt tccgtcgaag atcgcgtttg caacgtcact tgcttccgca cgagtcggac 2448781 gcgggttgcg ctgcatgctg tcaagcattt gtgtcgctgt aataacaggt ttgcccagcg 2448841 cgttgcattt tttgatcagt tctttttgca caagcggcac ttcttcagct ggaatttcca 2448901 cacctaagtc tccgcgtgca accattaagc cgtcagacac ttcgagaatc gcatcgatgt 2448961 tgtcaacgcc ctcttggttt tcgattttag ggatgatttg aatatcctga gcgttgtgct 2449021 cttcaagaag ctcacggatt tcgagcacat ccgtagaacg tcgaatgaaa gatggtgcga 2449081 tgaagtctac tccttgctca ataccgaaaa cgatgtctcg cgcatccttt tcagtaatcc 2449141 ccggaagatt gacacttacg cccggtacgt taacaccttt tttatttttg agtgttccgt 2449201 tgtttaatac ttttgttttg atttcgcgtt tagcggcatc tacatcaagt acctcaagac 2449261 cgataaggcc gtcatctaac agaatcgttg aaccttgttc aacgtcatgg actaaacctt 2449321 catatgtcac tgaaatttta tctgttgttc ctacaacctc gtccattgaa ataatgagct 2449381 ctttgcctgt ttcaagctca ataccgccgt tttccattgt atgtgtgcgg atttcaggac 2449441 cttttgtatc aagcagaatt ccaacgttct tgccaagttt tttacttgct tcgcggatat 2449501 ttttaattct tgcaccgtgc tcctcaaaat ctccgtgaga aaagtttaat cgagccacgt 2449561 tcattcctga ctccattaat ttcgtaagca tttcaatact ttcacttgcc ggaccgatgg 2449621 tacaaacaat tttagttttt ctcatttggt tcacttcctt ctgaaatctt cagccttcag 2449681 ctgtacatta gatagacagt tcttttgaaa gctgatacat gttttgctca actgtgtgtt 2449741 ttgtctcaag tatttctata atatcatggt ctacaagctt attgttttgt atacctacac 2449801 agcgtccgcc ttttccttca agcagcagtt caactgcata tgcgccgaga cggcttgcca 2449861 acacacggtc agcagcactc ggagaacctc cgcgctggat atggcccaat acagataccc 2449921 tagtttcaag atttgtttct tcttcaatgc gtttcccgaa ttcaacaccg ctgcctacac 2449981 cttcggcaac aataataata ctgtgcttct tgccgcgttc gtggccgcgt tttaagcggg 2450041 caatgatttc gtgcatgtca tagtctgcct cagggattaa gatcgattct gcgccccctg 2450101 caagaccggc ccacaatgcg atatcgccgg catgacggcc cattacttcg attacatatg 2450161 tacgttcatg agaagtcgct gtatcgcgaa tcttatcaat tgcgtcaatt actgtattta 2450221 aagctgtatc gaaaccgatt gtaaaatcag tgcccggaat gtcattatca attgtacccg 2450281 gtacacctac acatggaaac ccgtgttccg ttaatttttt cgcacccata taggaaccgt 2450341 ctccaccgat aacaacaagg ccttcaatac caagcttctt caagtttgct atcccttttt 2450401 cacggccttc aactgttttg aattcaggac atctcgccgt ataaagctta gtccctccac 2450461 gatgtataat atcgcctact gatccgagtt caagcttttc aatctttccg ctgatcaatc 2450521 ccgcgtatcc gttgtaaata ccgtaaactt caacgtcatg atagatcgct tttctgacta 2450581 ctgcgcgaac tgctgcgttc attcccgggg aatccccgcc gctcgttaat acccctattc 2450641 gtttcattct ccattcacct cagcaacata tatgattaaa cataacatga tcattgccct 2450701 aaaaacaatg aaaagggatc tccatcctcc ctatgaaacc ttacctatta tacaattaaa 2450761 taaattgttt ttaaataaaa tttaaggaat gtcacaaaaa ataaacgtga gccaaaggct 2450821 tcacgtttat ttagtttacc ccgatatatt gatcttcaac cgagactttg ccaattgctt 2450881 tatatttttc ataacgctgc tgaactaatt cttcttcgct cagcttcagt aaagttttta 2450941 acgattgttt aagggtttcg tccatatagc ttgcctgcag cttcacatca tggtgcgctc 2451001 cgccttttac ttctttaatc atatgatcta taatacctaa ttcttttaaa tccggcgcag 2451061 tgattttcat tgtttctgct gcttttttag caagactgga gtccttccat aaaagtgccg 2451121 cggcaccttc cggagaaata acagaataag tagagttttc cagcatatgc aagtgattgc 2451181 ctacacccag accaagggct ccgccgcttc cgccttcacc aatgacgatg cagataacag 2451241 gcactcgaag gccggccatc tcaaacaggt ttttggcaat agcttcactt tgtcctcttt 2451301 cttcagctgc tcgtccaggg tatgccccct tcgtatcaat aaaacagata attggtctgt 2451361 taaatttgtc agcctgtttc atcagacgaa gcgcttttct gtagccttct ggatgcggca 2451421 tcccaaaatt gcggactagg ttttccttcg tgtctttgcc gcgctgatgc ccgattaccg 2451481 ttacagggag gccgtggaac ttcgcaatcc cgccgacaat ggcttcatcg tccccgtacg 2451541 ctctgtctcc gtgacattca aaaaagtcgg taaacaggtg ttcgatataa tcaagagttg 2451601 tcggacggtc cgccagacgc gcgatttgaa cccggtccca cggcttcaaa tttttgtaaa 2451661 tatcatcctg aagcttagcg agacggtctt cgagccgttc gatttccgca cttagatcca 2451721 tatcggaatc ttgggtgaat ttttttagtt cggcgatttt ggtttgcagt tcaatcaccg 2451781 gtttttcaaa ttctaatctt ggagccactc aatgtcacct cctgtttgat gcatatccag 2451841 cagattttct aacgtttttt tcatatcgtc gcgatgaata accgcatcaa gctgtccatg 2451901 ttttaataaa aactcagccg tttggaagtc ctcaggcagt ttttctccta ttgtctgttc 2451961 aataatccgt cttccggcaa aaccgatcag cgcgccaggc tcagcgaaat tgtaatcgcc 2452021 aagggatgca aagcttgctg atacgccccc ggtagtcgga tgcgtcatta ctgaaataat 2452081 aagaccctgt tcttcactga acagttttaa cgcagagctt gtctttgcca tctgcatcaa 2452141 acttaatacg ccttcctgca ttctagcacc gcctgaagcc gtaaaaataa taaacggaac 2452201 tttatcagct tttgcttttt caatcgcaag cgtgattttt tcaccgacga ctgaacccat 2452261 gctgcccatt ctgaatgaag agtccatgac ggcgacaaca gccgggtgtc cgccgatggt 2452321 gcccttgcct gtcacaacag cctcgtttaa ggatgttttc tcgcgatctt tttcaagctt 2452381 ttccagatat cccgggaaac caagcggatt ttccgagagc attccctgat taaattcctc 2452441 aaaggattgt tcatccatca agctttcgat acgctgtttt gcgttcattg ggaaatgata 2452501 atcgcagttc atgcataccc gcatattttt atccaactct ttagtgagca tgattttttt 2452561 acacttagga cattttgtca taatgccttc cggaacatcg tgcttcgctt gatcagacgg 2452621 tacggaagca tactttttct ttttcgtgaa tatatccttt aacaaatgat tacctccctt 2452681 ttgtgaaggg ttctcttcac cgcatgtcat caaacagata gacttgctaa taactttacc 2452741 gaaactattg tacttttttt gtcaaacgct gtcatcctca attcgacaac tttttattcg 2452801 atgacgtgct cggaaaggct tgtatgaaat cagataaggt gttgaaacga caaggttgac 2452861 agcgcattca aaaataatgt taaacccggc tgaaattttt ttaaggctaa ccccctaaaa 2452921 aaatttcagc cgtcagttta acttgagaac agcgcgccgg tctccgccaa cgcgctgcca 2452981 tttttggaat gaattaaaat tattcaccaa taatcgtaag ttttcttgtt ttttctgcga 2453041 cttcctcagg gtcaacagtg attcttgcaa cacctgtttc catcgcagct tttgccacag 2453101 ccttcgcaac agcaggcgca acacgtttat caaacggtgc agggatgaca tagtctgcgc 2453161 taagctcatc ttctgaaacc agtgaagcaa tggcttcaac cgctgcgatt ttcatttcct 2453221 cgttaatatg agtggcacgc acatcaagcg ctccgcggaa aataccaggg aatgcaagaa 2453281 cattgtttac ttggttcggg aagtcagaac ggccagttcc gacaacgctt gctccggctt 2453341 cacgcgcatc ttccggcatg atttccggat ttggatttgc cattgcaaag ataatcggat 2453401 cttttgccat gctttgaacc atttcttttg ttaacgcgcc tgctacagag acaccgataa 2453461 atacgtcagc atcaacgata acatctttca gagaaccgtc tttgcgatct tggttcgtga 2453521 acttcgccac ttcatttttg acatcgttca tgccgttcgg gcgcccttca taaatggccc 2453581 ctttggaatc gcacatcaca atgtcgcgaa cgccataatg atgaagaagc ttgataatcg 2453641 caatgccagc cgcacccgcg ccgtttgcga caactttaat ggatgacatg gattttccag 2453701 acagtttcag cgcgttcaca agacctgcta cggttacaat ggcagtaccg tgctgatcat 2453761 catggaaaac cgggatgttt gtttcttttt tgaggcgctc ttcaatgata aagcagtttg 2453821 gcgctgcaat atcttcaagg ttgacgccgc caaatgtcgg ttccagcaat tttacagttt 2453881 caacgatttt atcaacatcg tttgtgttta aagcaatcgg gaacgcatct acgcccgcaa 2453941 agcttttgaa aagaactgct ttcccttcca taacaggaag cgccgcttca gggccgatgt 2454001 ttccaaggcc aagcacagct gtaccgtcag ttacaactgc taccatgttc cccttcattg 2454061 tataatcata tactttgtta atgtcttcat gaatatcctt acacggttct gcaacacccg 2454121 gagaatacgc gaggcttaaa tctttcgcat ttctgacctc tacttttgat ttagactcca 2454181 gtttcccctg gttgacttta tgcaggtgta atgcttcttc tcttaatgac attctcctaa 2454241 acactcctta tggatatttt ttgattcgta tactgctgcg ttgattgctg cattctgcgg 2454301 agtaaatcta tctgaatatt taaacaggat cacataattg ctccaattgt ataacaaaaa 2454361 gcgaatcgtt accactgttt taaaacgacg tttttttgac ccaacagctc ttttaagcga 2454421 tataacacct ggtgatctgc attgatatgg aacgactcag gtagcttaat cgtctgtttt 2454481 tgcctttcat aatagagata aacgcctgtt tcccctttat gctccagcaa aatgcgctta 2454541 atctttgcca ggatctcctg gctgtgctga ctgctttcta tttttatata aaccgatggc 2454601 gctttttctg catccatatc ttctaataat tctgcccggg acatgatgaa ttggatctta 2454661 tcttgtctaa cttcacattt ccccgcagtg aacaaaagag cgccttctct taaaacggga 2454721 gaaagctgtc tgaattgttc agggaagact acggcttcca tctcgccggt ttcatcactg 2454781 agcgttaaaa acgccatgtt ttgacctgtt ttcgtccgaa tcgttttgat cttcgacagc 2454841 agaacgccta gtgaaagctg ccttttgact gcccgctgag cctgcagaat ggagactgct 2454901 ccttgcgcag tgagctgttt tcggaaggcg gagaggggat gatttgaaaa ataaatgcca 2454961 agcgtttcct tttcaaacgc aagtaaatcc accagaggaa gctcctccgt ctccacatac 2455021 ttcggcttaa ttgaaaacga ttcatctaaa aacaatccca tttggtcatc gtccgcggcg 2455081 aatagctcag catgttccaa agcaacatca atggatgcga gcagcgtggc ccggttttgg 2455141 ccgaattcgt ccatcgcacc agaaaagata agtgcttcaa gcattttgcg atttacgctt 2455201 tttgacggca cgcgaaagca gaaatcgaaa agatcttcaa atggtttctc ttttcttgct 2455261 ttatatatat ctttgactgc tgagacgcct acacttttta tcgcgcggag gctgtatctg 2455321 acagatccgt tttcaactgt aaacggaaaa ctgcttttat tcactgacgg aggaaggata 2455381 cgaatcccgc tcccctttgc ttcgtaaaga tattgagaga ttttatcctc attgccaatg 2455441 acgcttgtca gcaatccgca cataaaatat aacggataat gagctttcaa atacgcaagc 2455501 tggcacccga tcatgctgta tgccaccgca tggcttctgt taaagccata gtttgcgaat 2455561 ttgacgatta aatcgtagac ctcatttgca gtgtctacag aatactcctt ttttaagcac 2455621 ccttcaacaa aatggcttcg ctctctgtcc aggatttctt ttttcttttt gctgaccgcc 2455681 cttctcaata ggtccgcttc gcctaaagaa aaccccgcca tacgggaagc aatcatcata 2455741 atttgttcct gatacacaat gacgccatat gtatcttcca aaatgctcct taaatcttca 2455801 tgaggatagt gaacaggcgc ccgaccgtgt ttacggtcga taaataacgg aatattttcc 2455861 atcggacccg gccggtacag tgcattgacc gccacaatat cttctaggcc cgaaggtttc 2455921 agccgtttca agacgcttct catccctgca gattcaagct ggaaaatgcc tgtcgtatcc 2455981 ccttttgaca gcaaggagaa cgttttgtca tcgctgtagg aaatacttga aaggtctatt 2456041 ttaatatttt cttctttttc aatcattgaa gtgatggatt caataagtgt cagattcctc 2456101 aaacctaaga aatccatttt taaaaggccc aagtcttcaa gatggtccat cgcgtattgc 2456161 gttaaataga tcccttcatg cccttcttga agcggaacaa catctgttaa cggttcttca 2456221 ctcaggacaa cgcccgctgc gtgggttgat gcatgccttg gcagcccttc tattttccgg 2456281 gcaattgaat agacttgctg aagcaggctt gactcccgaa gccgcttatc cagctgcggt 2456341 gactgctgtc tcgcttcatc cagcgtcatt cccggtcttg aaggaatgag ttttgcaagc 2456401 tgatctgcct ccttcgggct gacgccgaat actctgccga cgtcccggag cgccgccttt 2456461 gccgcaagtg ttccaaaggt gataatctgt gcgacgtgca ttgcaccgta tttctgctga 2456521 acatattgaa tgacttcatc ccttctagta tcgggaaagt caatatcaat atccggcatg 2456581 ctgacgcgtt cgggatttaa aaatctttca aacagaaggt gatgcttaat cgggtcaaca 2456641 tctgtgatat acagcacata tgccacaaga gaacccgccg cagaacccct tcccggtcct 2456701 gtaacaatcc ctttttcatg ggcgtgcttc ataaaatccc acacgatcag aaagtaatcg 2456761 ctgaacttca tccgcttgat gacatcaagc tcatattgaa gacggcgaag gtatcgttca 2456821 tcaggcttgc cgaaacggct gcggagtccc tccatacaga tatccgttaa ataatcatca 2456881 gcggacgttc cgtctggggt cggaaaagac ggtagacggg tctgcccgag actgacgtca 2456941 acccggcatt gttccgcgat ctctacagaa gcttgcagtg cctcgggatg ctctcgataa 2457001 atgttttgca tttcttcgag tggtttcaaa tcgagatcag gcaaatcttc agcgggtgca 2457061 tccgtcagtt tttcccccgc tttaatcgct ttcaaacaac ggtaggcagc cttatcttcc 2457121 ttccttatgt aatgcacatc gcctgtggcc gtaacaggga tacccgtttc ttctgacagc 2457181 tttagaatct gctcagacaa gacttgattc cctttaaaag gctgatagga gaaataaaaa 2457241 gctccctttc cgaatataga ctgaaattcc agcgaggctt gagcagcctg ttcgaacagc 2457301 cctccttcaa gaagcgtttc aatatatcct ttttcgccgg gcgttattgc gataatccct 2457361 tctcgataac tgtgaagcca tttcggcttc agtccgcctt ttgatttaga ttgcagaacg 2457421 ctgctgattt tcagcaggtt ttgatagcct gtattcgatt ttgccagcag gacgagcggg 2457481 tatgcttcaa gctcgctgtc atctgtaaaa acagaagccg tcaaaccgat tattgggttg 2457541 atccctctcg ccttgcaagc tttataaaat tgaatagctc cgtacatgac atgatcatct 2457601 gtcagcgcca aagacgcata tccgagcctg tcagcttcac tgacgagttc ttccacagcc 2457661 gcggcgctgt ttagcaggct atacccgcta tgcacttgca ggtgaacaaa agacatgcta 2457721 tcacctcttt ctcattacga tccatttctt ccttcattat aaggccggtt tccaaaagaa 2457781 acaaatgttc ttttttgact catcatcata cttgtcctga aagctcaata tgatataaaa 2457841 ggtgaggtga taaagatgga tcaggaagca ggatttatgg tgaattttat caatagctac 2457901 ttcattgcgt taggggtgct gatcgggggc gcactcatcg gagggctcgg agcatacttg 2457961 gcaggcgaac ccccgcttac agccattaca aagcttgcca accggttaaa aatatgggcg 2458021 cttgtcgcag ctatcggagg cacctttgat gcggtataca gctttgaacg cggcatactc 2458081 gaaggcaata cgagagatat ctttaaacag cttcttttaa ttatttcggc catggggggc 2458141 gcgcaaagcg gctggcttat tatatcatgg ctgacccagg agcatctttc ttcatgaggg 2458201 tcccccagca ttacaaaaaa ccgggatggc agcgtttttt cgcgggaatg atgtgcggag 2458261 ccgtaatcag ctggttcttt ttcctgttta cttacggaac attccaagag gagcaggtca 2458321 gcctcatcga aaagcaaaaa gagcatgtaa aagacttgaa caatcaaatt tcgatctatc 2458381 aggaagacct ccataaactg aatgaagata ataaaagaaa actgctgatt caaagcgtca 2458441 gcgtcaaatt gctgaatggg gataaatata aaatatcaca gccggataaa acgaaattcg 2458501 aggagcatgt aaaggatgat atttcagagg tgattacaaa agacatagag agcgtctatc 2458561 aaacaaagga tctcttgaag cggacaattg aaaataaagt ctatatgatc aatgaaaaaa 2458621 aatacgaggc aaccgtcaga gaattgatta tttatacgag gctgacagtg gaacttgaaa 2458681 tttctttcgc cacataatta tggatttttt ttaaattctc caaacttctg tcgctttttc 2458741 ccattctttt ttataaacta tatgtgaggc ttaatggcga aaggaaggag gaagggaaat 2458801 ggaggtttac agtgaccgtc agttagcaaa agatcaagca gcccgtctca gacaaggttt 2458861 ttctgcatat gccgaaacaa actcactcgc ttccctcatc aaaaaagaac ttcaatcaca 2458921 caatctccaa gtctacgagg accttactga tttcggctgc tggttcatcc ccgtcacaga 2458981 tgaacactaa gagagagggt ctcccctcta ctcgtgttct ttacataatg tttccagatc 2459041 agctaaaata cgatcagctt catcccagct gtaaatagag gcgcctgaag ctaacggatg 2459101 ccctccgccg ttatatttcc gggcaagtcc gttaatgaca ggccccttcg aacggaatct 2459161 gactctgatt tgatcgtctt cttctacgaa aaacacccag gcgcgaatac ctgagatatt 2459221 gccaagcgtc ccgacaagct gcgacgcttc agaagccgtt gtgccgaatt tttcaagcgt 2459281 atcctttttg atgaaaacag aagccgcccc gttttcggac aaagacacat tttgaaagat 2459341 aaagccgtta agcttcacca cattcagttt tgtttcatac aattgattaa ataactctga 2459401 ggaagagaat ggatactgaa tgagctcgcc tgcatatttt agtgtttttt ccgtggtatt 2459461 cggaaataaa aagcgtccgg tatctccaac aatgccggcg tagatcagct ctgccgcttt 2459521 cgtattcagc ttccagccgt gctcttttcc ttctaaatac agctcgtaaa tcatttcact 2459581 tactgagctg gcgcttgtat cgacccagag aaggtcaccg tatggatctt cgttcggatg 2459641 gtggtcgatt ttcattagtt tggcgcctga aggataacgc tgatcgtcga ttctttcctg 2459701 atttgccgta tcgcagacaa tgacaagtgc gccttcatat gtttcattgt ccacctcatc 2459761 aagggaatat aagaaagaga gggacggttc aggcgtgccg accgcaaaaa tatttttttc 2459821 aggatatgtt tcacgcagga tttccgtaag cccacactgt gatccgtagg catccggatc 2459881 aggacgcaca tgtctatgta agataatcgt gtcatataat gatatggttc tgatcaattc 2459941 tgttttcatt tgatactcct ttattgtttt tattcattaa atcacattct ctgccgacgg 2460001 aaaagaaaaa taacgtcaaa accaagcccg tttttgtata aaatggggtt gtaaactttt 2460061 acgatggagg atttcattta tgctggttct tgtttttttg attgggcttt cagcctgctt 2460121 ttatgtgtac tataaagtaa aaggcgtacg ggcaaagcca tctttggcaa aagaaatatg 2460181 ttcagcaaaa tcaagcatgg ccttagggtc actagtcctg ttctacgggc ttaaccaaat 2460241 gatattattc cattcagtat taacgttagt aatcggcggt atctttatcg tcataggagc 2460301 aggaagcgct tgggcaggtt ataaagcctt caggcattac aatccccttc acgccaaaga 2460361 agctgaaaga gatcacgcgt aaggggcgcc tgaacgtccc ttagcttctt tccatcagct 2460421 gaaccatcag catcgcttta gacacgatat gaccttggct gtgcacttcc acttccattt 2460481 tcccaaactt tctgccggcc tccaagatgc gaggtttgac ttcgatgact gattccatct 2460541 gcacaggctt caaaaagaag atggtgatgc tctctatgac gagttcgccg cgttttttcg 2460601 agcgcaaaaa tcggtttgcc gcttgcgtca aaatggtcgt aaatacgcca taagaaatgg 2460661 ttccaagctg atttgtcatt tgcggcgtga cttcatactc gtaaaccgtt tgatcttctt 2460721 tatcatcacc ctcatcttta aacccccttg aaacgatatc atcaagcttc tccccgacct 2460781 gcggctgctt ttgaatcatt tgaagagctt tcaatacgtc ttggcggctg atcatgccga 2460841 tgagtttttg gtggccgtca gtgacgggaa gcacttcgat cccttcccat accatcattt 2460901 gcgcagctga agcgacagat gttttcccaa taaccgtgac gggatttttg gtcatgactt 2460961 tttctataga tgcatttcgg tcatggccag caatatcttt tgatgtcaga atgccatgga 2461021 ttttcatttg atcgtcgaca accgggaagc ggccgtgccc cgtttcaaaa tttttctcat 2461081 accatttttc aagtttatcc ttaggcgaaa gatataccgt gcggtcagca ggtgttagga 2461141 tgtcctccac caaaacaatt tcttttttga tcagctggtc atatattgcc cggttaatca 2461201 tcgcggcaac tgtaaaggtg tcatagctcg tggataaaat cggcagttca agctcatctg 2461261 ccagctgcac aatgctgtca tccgtgttaa agcccccggt caccaatacg gccgcgcccg 2461321 cttcaagcgc ctgcctgtgt gcattgattc tgtttccgac aatcaaaaga ttccccgctg 2461381 cggtgtaacg catcatcgcg tcaagctcca tcgcgccgat gacgaattta ttcaatgtct 2461441 tatggagccc tgccctgcct ccgagcactt gtccgtctat aacatttaca acctctgcat 2461501 aggtaagctt ttcaatgttc tcttttttct tttgttcaat tctgattgtg cccacacgtt 2461561 caatcgtgct gacaaaccct ttattctctg cttccttgat cgctctgtac gcggttcctt 2461621 cgcttacttt catttccttt gcaattcttc ggacagaaat tttttcaccg acaggcagtg 2461681 aatcgatata cgttaaaatt tgttcatgct tcgttgccaa gcctttcacc tctaaggaca 2461741 gtcttcttgt ttttattata aggtttcaaa ggatttatac gcaatgaggc tggaaaataa 2461801 aaaagaagcc cgaccggctt cttacagcgt tgatttcgtt ccagtcaaac gcaaggacca 2461861 cgtgattcct tttacatcgt aaagcggaaa aacctttatt tttcttttaa atggacatca 2461921 accgctgtct taacaatatt tcgattccct attttagata aaacaaataa aactgcggat 2461981 agccatatcg cccctatggc cgtatagatc aatggatgaa cagctgtgtt tgcgatccat 2462041 tcatttatta atgttctggc atttaccaga ataataaatc ctcctacaag cacacccatc 2462101 aattgcggat gaaacttctg caccagccat gctgcgatag gggcagcgat aattccgccg 2462161 gccattagtg aaaacaccca taaccaattg acgtcctccc atcctaatga aataagaaaa 2462221 ccggcggttg cagatacggc gatggcaaat tcacttgtgt ctacagtccc gacaactttc 2462281 ctcgggctca agcctttgcg ggataataaa atcggagtgg tcaccggtcc ccagccgcct 2462341 ccgcctgtgg catctgcaaa accagcgatc actcccaatg ggatggattg ttttcggttt 2462401 aacggcacat gcttcttctc aagagccggc ttatattgaa ataaaaacct gatcaataca 2462461 tatccgccca gaaggagcaa aaacaaagaa atatagggtt tcgccacatc tccaggtaat 2462521 tggctgagga atgccgcgcc taaaaaagcg cctatagagc cgggaatgac aagctgataa 2462581 acggtttgtt tgtcaacatt gccaaattta atatgcgaca ctcccgatgc ggcagtcgtt 2462641 acgacttccg ctaaatggac agaagccgaa gccacagcag gtgtgatgcc aaacgccaat 2462701 aacaaagaag ttgaggtaac cccataagcc atacctaacg aaccgtctat taactgcgac 2462761 aataaaccaa taaatgcaaa aacgattaat ttcttcatca gaacacccca tctatatcaa 2462821 tcagatattt ttgactcttc attcgaatct aacaatctct tggcgctttc atataaaaaa 2462881 taagaggctt tgataattgc agtttcatct attgtaaatg cagggtggtg ccaatcatga 2462941 tcaccgtctg ttccaaaaaa cgcaaaggat cccggaatat gctcaagata ataagcaaaa 2463001 tcttcccccg cggttgatgg ggcgggatca atgacttgaa gtttcgcttt atgtgcagcg 2463061 tctcgcacca gccccgtaat tgcctcatca ttacaaagcg gcggcggtcc ggaatgccac 2463121 ttcacatttg cctttaacga gaaagcggca gaaatctgct ctgtgactgc aaaaaaacgc 2463181 tgtttcactt gattacgaac ctctgaatca aatgtacgaa cagtgccctc aatgaccact 2463241 gtatccggaa tgacattcca agtgctgccg ccgttgattt tccctacggt taaaatcgcg 2463301 ctttgcagcg ggtttacatt tctgcttaca atcgtttgca gggcgacaat aagctgagag 2463361 gcgccgataa ttggatcaaa accattatgc ggcaatgctg catgagcacc tttcccttct 2463421 atctctactt taaatcggtc aacagcagcc ataagcgggc ctgtttttaa ccctacagtc 2463481 ccaaccgcga tatccggttt attgtgaagg ccaataaccg catcaatgcc atccagttgg 2463541 ccgtcctcta tcacttttgt agcgcctgca cccgcttcct ctgctggctg aaataataaa 2463601 cgaatctttc ctttcagact gtcttgattt tccttcaata aaaaggccgc accaagaagc 2463661 gctgccgtat gaaaatcatg accgcacgca tgcatgatcc ctttatgttt agacgcataa 2463721 ggcaatcctg ttttttcttc aattggcaag gcgtcaatat cagccctcaa agcaatcgcc 2463781 ggaccttctg actcccctgc tatgtctgcg aacacacccg tttttagagc agtagggcga 2463841 atctgtatcc ccttttcttt aaggcatttt tttataaaag cagttgtttc aaattcttct 2463901 tttgacagtt caggatattg gtgcaggtgc cggcgaatgc cgatgagctg cttttctagc 2463961 gttgagagat ttacgggatt agactcctct ttcaacgtca ggatgtcatt tcctgtagtc 2464021 tgatatggat aggagccttc tatatttctc caataatcca aagacatatg ttccgctcct 2464081 ttccctatcc caatatattt tcttcagact cttcaacata agatgaaata aatcggttca 2464141 atttatcagc aagaccgccc gccccaaatc ttatatactt gctggaaact ttcggattat 2464201 cttctttcaa aaagcttaaa aaagataaaa tataaatgcg cctgtaagct acttgtgtaa 2464261 ttccgtactc aaaaaaccag ttatcaatga cattgtatac gcctcggttg acgccatata 2464321 ggttattaca tttcttgtaa aagcagagat ccggaagatt taactcctga tgggaaagaa 2464381 ggctttcttt tttgtttggt gccataatcc caatcagctc aaagcgtttt gcaacgcacg 2464441 aaatatcctt tttaatttgc tttgttaaag actccaaaga atcaaacctt ctttcttctc 2464501 taattttaaa gagaatgctg cattcgattt tttctccata aatgtctcta tgaaagtcaa 2464561 acaaaaaaat ctccaatgtc ttttcaaggt tagagcccac cgtcggtttc acaccgatat 2464621 tcataacccc taaatgaaat tgatgattga ctgtcgccag aaccccataa actccattac 2464681 gcagcccatg tatttttgca tctacatttg ccgtggggaa tccaagcttt ctgcctaatt 2464741 gttttccttt cacaaccgta ccggcaatga tcgtcaaaaa agtcagcctc ctctctcagc 2464801 ttccgcattc gatcagacga aacctaatga tgtgatgaat gtaaaacgga ttgatgctgc 2464861 ggaatgccaa gaccgagatt ttcccgcaat gtcccgccgc gataatcttg acgataaagc 2464921 cctctttctt gaagaatcgg aatcaccttt tctacaaaag catcaagtgt tcccggtata 2464981 tccgacccaa cgataaaccc atccgccgcc tcagcgttga accaagtttc aattaaggat 2465041 gcgacacgct ctggtgttcc gatgaataga gtccgtggaa aagccatttc ctgtgctacc 2465101 tcccgcaatg tcagatttct ggcttttgct tctctcttaa tccggtctgt tgtgctttga 2465161 aacgcattct ttcccacatc gccaatatcg ggaaatggct catccaacgg gtaaacactc 2465221 agatcataat catcaaaaaa acgggccaaa taagtaacag cattttcaat cggtatcaat 2465281 tctgcaaatt cacgatactt cttttccgcc tcttcttccg tatctgccac aatcgggctg 2465341 atccctggaa aaatccgcac acttgaagga tcacgccctt catcagcagc tcggcttttc 2465401 acatccgcat aaaacgcttt tgtctcttct aatgaattgg aatgggtaaa aatcgcatcc 2465461 gcatttttag cagcaaactg ccggcctgtt tctgatgaac ccgcttgaaa cactacaggc 2465521 tctccctgct tagagcgccc gatattcaag ggcccctcta cttgaaaata ctttccttta 2465581 tgattcaggc gatgaagctt cgcctgatcg aaaaactgcc ctgttttctt attgtgtata 2465641 aatgcgtcat gctcccagga attccacagc ccgcgcacaa catccaaatg ctcttgtgcg 2465701 atctcgtaac gttcagtgtg ttctggcaaa ttagacttac tatggttgcg cgccgctcct 2465761 tcctgcggcg aagtaaccag attccagccg gccctgcccc cgctgatatg gtccagcgac 2465821 atcaattgtc tggagatagt gaatggctca gtaaaagatg tagagaacgt ccctactaaa 2465881 ccaatatttt tggtaaccga tgccagcgca gataaaatgg tgatcggttc aaaacggttt 2465941 aaaaaatgag gaatcgattt ttcagaaata aataagccgt ctgcaatgaa aataaaacta 2466001 aacaaacctt tttcagctgt ttgcgccttt ttcatgtaaa attcaatatt cgtgctggcc 2466061 gagggatcaa catcgggatg acgccagccg tcagttgttc ccccgacacc gtgaatcatg 2466121 gctccaaact gaataaaatc tgcacgtgtc atctttttgc ctcctttatc tgtgcatgat 2466181 tagcaagtgc aagatcaagg tgttcaatgc cgatttcagt tatcccttga tactgattgc 2466241 cgcgcccgat ttcgaccaca ggcacatggc gcaccccata tttcacctgt aaaatatccc 2466301 gaagcttttc tttctctgaa acatcgatat tttggaacgg gaaccctttt tcattcaaat 2466361 aattcttgac ttcctcacaa tacgaacagc cttttttact ccaaaccaca atgttcacaa 2466421 catcactcat tcttctgtcc ctccttaacg ttttgcagct aaaactgcat cgctcagcag 2466481 ctgataagac agctgttttt ctacagcatt tttgatcggt gtaaaaataa caaaatcatt 2466541 gattttgtat gtgcctgata aacgtgttaa ttcttctgcc acttcttcct ttgttccggc 2466601 aataatcccg gttttttgca cgatgatgtc atagggctct gtgacgtttt ccagataggc 2466661 ctcagcctgt tcgcgggaac cgacgttgac cttacgcccg tctttcaaaa ccacttttat 2466721 cgattcacgc gacacaatat gtttttccgc ttcttctttt gtatgtgccg caaaaacagc 2466781 gggggcaaga tgaaattcag cctcagatcc tggcgggaga tgcgcgtcaa atgctcggcg 2466841 ggcttccttc agcacttcct cttcaccgtt aataaagtaa gcaaagacaa aagagattcc 2466901 cagttttgca gcagaaatgg cactctctgt gcttcctccc aatagaaaaa tacccggctt 2466961 ccgatcaacc tgcggcctag gacgcaatgc ggcatagcgg tgggtatcag gaaaatcatc 2467021 ccgaacgaaa tgagtaagct cctccagttt ttcatcaaac tgacgcaccg gttttttata 2467081 ttcggcctgc agcgcgtctg tggacagctg aaacccgccg ggcgctttgc ccactccaag 2467141 atctatacgg ccgggagcta acgctgatag aagatggaat tgctccgcta ctttataaga 2467201 gctgtaatgc tgcagcatca ctccgcctga tgctaaacga atttttcttg tgcttgcagc 2467261 aagatagcct aaaagaacct cgggtgcaga ccctgcaatc tcatcattgt tgtgatgttc 2467321 ggccacccaa aatcggtgat atccacattc ttcagccatt tgtgccaatt tcactgtatg 2467381 ctgtaatgta tcagctgctg tctccccttc accaatcaag ctttggtcta aaatacttaa 2467441 gcggatcata tcaccggctc ctttatgtgt tcttttggtt caaataaata ttccggcgaa 2467501 acacggcgga gaaactgcct cgttctgtct tttttggtat ggcggaagac ttcctccggg 2467561 gttccttgtt caacaatgac tccttcatcc ataaaaacaa cttgatcaga gacccttctt 2467621 gcaaactcca tttcatgtgt aacaacaatc atggtggctc cggttttcac gatttccagc 2467681 attacctcaa gcacttcacc gaccagctcc gggtcaagcg ctgccgtcgg ctcatcgaac 2467741 agcagcacat caggatgaat ggcaagcgcc cttgctatcc ctaccctctg cttttgtcct 2467801 cccgataact gactcggata agcgttcaat ttatcttgaa gcccgacctt tctcagttca 2467861 ttttccgcta cggcatacgc gtcttgtttt ctcattttcc gggcaatcgt caagccctcc 2467921 atgacatttt caatcaccgt tttgtgagca aacaggtggt attgctgaaa taccattgcc 2467981 gtctgttttc tgagccagtg aacctctttt ttggacggaa agcggcaatt aatcactttg 2468041 tcatgtatag aaatgatccc ttcgtctgga cgttctaata aattcaggca ccgtaaaaag 2468101 gtggttttcc ctgatccgct cggcccgata atcgtcacaa cttctccctt gcgtaccgtg 2468161 agatttatcc cttttaatac atggtggatg ccaaactgtt tatggatatt tttaatctca 2468221 atcataaagt gcctccttga aatctggctg cctttctctc taatactcca tttgcggatt 2468281 ctaggattag agtcagcacc caatagataa tcgctgctcc gataaacgct tctaaaaatg 2468341 cataattatc agaagcaacg atagtcgccg tccctgtaat ctctgggaca gccactatag 2468401 ccgcgataga ggtggtatgc aaaaagccga tacccaaatt tgtgaagttt gggatggaaa 2468461 ccttcagcgc ctgcggcaat attacacgcc gaaaggtttg gctgtatgtc aagccgattg 2468521 aataagccgc ttcgacctgt ccggtatcca tcgccagaat gcccgaccgg atgatttctg 2468581 tgagataagc tccggcagtt aaagacaagg ccatgatgac aaacatggag accggtatct 2468641 cattagcgga ccagccgaga tgaaaaaaac tgctgacttg atctgcaaca ggcggtatcc 2468701 ctaaataaat caacataatg tgaagaattg caggtgtact tcgaaagaaa gacacataaa 2468761 accttgagca agccaccaag cccttaattc taaaaattct aacaattata tttccaagag 2468821 ccacgagaaa tccaaacaca atcggcaaaa cagccatcat caatgtcaga ggaatggtct 2468881 ttaccatttc tttcatggcg gaaacgataa atggaaagtc aaattgcaat cttctccccc 2468941 ctcatccgaa gaaatatatc aatgtatgtt catgtcaaaa acagtaacaa tccttgtttg 2469001 attcttcttg attcgttttt ctgccactcg aaagaaccat tcgaataaaa ccgctacagc 2469061 ataataaaca atcgatagcg caatgtaaac ttcaagagaa tggttgcttg aggtaatcag 2469121 tgtttggccc cttccggaca tatccataac acctattgaa aaggctagag acgtatcttt 2469181 taaagaactg atcaccatgt ttcccatatt cggaaacgcc tggacaagtg cctggggcag 2469241 aacgattcgc ctgaaggcct gactaccgct taagccaata ctgtacgccg cttccgtttg 2469301 gcctttatct acactgccca cccccgctcg aatgatttct gcggctgccg ctgcattgct 2469361 taacgcgtag gttgcgacag cagcataaaa cgggtccatt tttgatgtat caatcccgat 2469421 aagccccgta agcgccggga tcccgtaaaa cacgatgaaa agctgcacca tgataggcgt 2469481 tcccctgaaa aacgagatat acacttttgc caattgattt acaattggaa tattatagat 2469541 gcggggcagt gccagaaaga gtcctaatac aaaaccgaaa agcaaggaca gtgttaaaat 2469601 gtataatgta accggtaaat aagcggttaa cgtcggcaca aaatctccaa tcatgttcat 2469661 atcaaacgct ttttccatca ctgctccctc tctttttacc taatactgct ctttggaata 2469721 gtcgtcacca agccatttca aactgagcct tttcaacgtt ccgtcatcaa tgatttcctg 2469781 taaggcttta tcaatatcgt cacttaacgt ttgttcattt ttgttaaaca taaaatacac 2469841 tttggcattt gaaagcacat taccgacggt tttttcttta atagtgctcg tcttgttttg 2469901 aaagtctact gcaaaaggcg ttgagatcgt tgcgtccgca cgccccgatt tcagctgatt 2469961 cgcagtctca tttgcgcctt ggccctcata ggcaatctca aacggccgtc cattatcctc 2470021 attccatttt ttcagtacaa gcgctccgtt ggaggttgca ctcgtaatca cccgttttcc 2470081 ttttaagtct tcaattccac ggatcgtatc gttattttga agcacagtaa tttttaaagg 2470141 aaaatggttg taagcaacct tgttaaacag aaattttttc tcacgctctt tgcttttctc 2470201 catttgatgt gccacgatat cgactttatg ctgtccgagg ctgacaagca ggttggaaaa 2470261 ttccatcgtt ttaaatgtga atttataatg tggcaggcgc ttatcaagct ctttgatcag 2470321 ttcgacatca taaccggtta aatcgccttt ttcatcgata aagcaaatat tcggaaattg 2470381 ggttccagtt ccgaccgtga tcgtctgtac cttcttttgc ccggctcccg tcgtttgact 2470441 gcctgcaccg caagctgaca gaactgttat aagcgaaaat aatattgcca tgaatgctgt 2470501 tttcgttttc atctcatcgc cccatttatt tttcaaaact tgattttgaa taatctgccc 2470561 cgagccattt tcggcttagt ttttttagcg ttccgttttt ctccagcttt ttaatcgctt 2470621 gatccgtgtc atccgccaag gtttggctgc ctttattaaa cataaagtac acctcggtat 2470681 ctaataacac gtcaccgact gtcttttggc ggaaggcgtg cgttttattc tgaaaatcga 2470741 cggcaaacgg tgtagctatc gttgcatctg cgcgcccggt ttcaatttga ttggcggtat 2470801 cattgcttcc ctgtcccgca tatttcaaat gaattgggct gccgtgcgtt ttgttgtact 2470861 ttgtaatata atctgccgca tttgacgtgg cgccaactat gactgttttt ccgtgtaagt 2470921 cttttaatgt atgaatcttg tgattatcct ctttcaccgt gatgtacatc ggcgagtagt 2470981 tatatgggac tttatgatac aaaaaacgct tttctcgttc tttatttttg gccatattgt 2471041 gcgcaatcac atcaattttt ttatttccga gactcgtcag caaatttgag aaatccatcg 2471101 ttttaaattc aaatgtatat tgaggcaact ccttatcgat ggctttcatc acttcaatgt 2471161 catacccggt caattcacct ttttcattta aaaacgcaat attcggaaaa tctgttccag 2471221 tgccgactat gaccgtttga gcctgacgat ctgttttgtt atttgtttgc gaacatcccc 2471281 cgccaagtaa tgcaaacact gacagcagca aaaccaatcc tttacgctta ttcataggct 2471341 gcctcacatc atgcccagct gggcgcacct aaaagcgttg ggttaaatcg ttccggaatc 2471401 agaaccttgt gcatcatcac acctatgtcc ccgtcttttt cctgctcaaa atacacttca 2471461 taccctctcc ttctgtacat gtcagcaagc caaggatgct tgcgcgccga tgtgccgagt 2471521 gtcagcgcag gagccttcag catatctcga agcacttttt cttcaacata cgtaagcagc 2471581 ttacttccgg cgccttgccc tttatattcc ggcagtgtcg caaaccacca cacaaatgga 2471641 tattttgaag gaggcgtctc actctcccac gggaacctga ttgtaatcgt tgaaatcagc 2471701 ttcccatccc gctccagcac aatcgctgaa tgatgttcaa tattttctga taccatttgg 2471761 atatcagctc tcgtggatgg ccaatcaata tccagctgcc gaatgggctg aaatgcgctg 2471821 ttaaccagtt tcaacagctc cgatgcatct tcaacagttg ccagtcgaaa aatatcatca 2471881 ctcatttttg tcactcctct tcacaaaata tataattcct atttgtttac taagctttta 2471941 ttgtttatac tataaagcat actctgatct ttgactaatc aaaaaaagta aaccttcact 2472001 tcagtaattt taatgatgaa aaacaggagg gagcacattg gagttacgct caatcaaaac 2472061 gtttcatacg attgtaaaat ttggaagctt ctataaagct gcagaaatac tcaactactc 2472121 gcagccgacg atatcgatgc gtatgaagca attggagcag gatttaggcg tactgctgtt 2472181 tgaaagagga aaaagcctgc agttgacaaa agcagggaag cttttttatg aacgaacagg 2472241 agatcttttg atgcaatacg aggcgcttaa acacaacctc tccgacttaa aggaagaaga 2472301 ggcaggcatt atcaacatag gggtttcaga gccaaccgcc agtctgatat tccccgagat 2472361 tttaaaggat ttcttaatgg attacccaaa gataacggtt aatatcaagg ttgatgacgc 2472421 caatacctgc agtcaaaagc tcttagacgg gacgattgat tttgcagtct gcggcgagcc 2472481 ggagctgatt cttgaaaatt actaccatcc atttttttat gacacattaa atgtgattgt 2472541 atctgatcaa catccgctcg ctgagaagaa ggctgtccat ttgtctgatt tagcagaaga 2472601 gcgcttcata tttacgcccg ccaattgccc cattcgctta caaattgaac agcatttaca 2472661 tagagaactc gggaatcgct acaaaaaaat ggagctcaca agcagcatgt cacatgaata 2472721 ttacgtacgt gaaaacatcg gaatttcaat ctttaccagc accgcacatt ctaaaccgtt 2472781 caacggcact aaagtcattc caattctgaa cctggatatc accccgccca tagggctgtt 2472841 gacaaatcaa aaagaagttc attttgaccg cgccacgaag gacttgatcg cccggataac 2472901 caaacgtttt cagcagcgca gcaaagaatt ggaaggaacc tctgataaga ccattacagg 2472961 ataactgaaa aaataaaaac cacctcctga ttcatcagga gatggtttca cggtttaaag 2473021 ctcgatcgtc tcaccgaccg acatgacttt gccgactccg cccggcaggc tgtcagcgaa 2473081 tgcttctggg tcttgttcga tgaccgggaa tgtattgtaa tgcaccggca cgacctgttt 2473141 tgcgcgcagc cattcagcag caagcttggc gtcttcaggc cccattgtaa agttatcgcc 2473201 aatcggaagg aaagcaaggt cgatatgatt caattcgcca atgagtttca tatcagagaa 2473261 aagtgccgta tcgcccgcgt ggaaaatcgt tttatcttct acagtcagca aaataccggc 2473321 aggcatgcct gtgtaagtga tcgttttgtt ttcttcatct gtgatggctg atccatgaaa 2473381 ggcctgtgtg agcttcactt ttccaaaatc gaactggcgg gagccgccaa tatgcattgg 2473441 atgaacattc aagcctttcc agcctaagta cacagcgagc tcgttcgggg ctataaccag 2473501 cgcgttattt tgcttggcga tttgttcagt atcaccgaca tggtcattgt ggccgtgcgt 2473561 tagtaagatg acatccgctt ttacatcctc cggctttata tccgttaatg aattccctgt 2473621 taaaaacgga tcaaaaataa tatgatggtc cttcgtttcc actgtgatta cagaatgtcc 2473681 gtgatatgtc actttcattt ctttcacctc gtcacatgat tttgtttttt ttattttccc 2473741 tttttaaaaa gctgaaaaac ttatgttgtt tgattcttgt taatgacatt gaggcctccg 2473801 gtggcttcaa tgacagtccc tgtcacaagg tctgagttct cctcacacaa gaaagcgata 2473861 atcctggcaa tatcctcgcc tgtaccggat cttcctatcg gcgttttttc tttgccgatt 2473921 cgcattctgg cttcctctat cgatgcttct ttcatgtcgc cgacaatgtc tcctgggcaa 2473981 accatgttgg cggttatgcc gaattcggct tcttcaatgg caattgtctt cgtcaaagaa 2474041 gccaagccca ctttcgcagc gccaaatgcc gatcggtgaa gccagccggg cgcgtgagcc 2474101 gcaccttgga atccgtacgt aataatgcgt ccaaattgct gttttctcat aataggaata 2474161 accgctttga ataaatgaaa gacggcgctt aaatttcctt ccagcatgcc ataccattca 2474221 tcatcagtat aatcggctaa ctttttacgt tcaaatatgt atggtccagc gttgttaatc 2474281 aaaaagtcga tccttccgaa gcggtttaag gcagcctctg caatacgcag cagatcttct 2474341 tttttggtga catcaccttt tacaaattgc agccggtcaa gacaatcggg acaggcttcc 2474401 ttcaggcggc tgactgcctc ctcatcctgt ctgtaattga ctgttactga ataccccttt 2474461 gcaagcaacg tttcagtcac tttgcggcct aaacccttcg aaccggcagt aattaaagca 2474521 tgtcgcacat gaatacctcc caaagcaacg tcgccgcttt caataaagtg tttcttcttc 2474581 tactttacta taaaaggctt gcaatatcac tttttacact ttggcataca aaaaaagctg 2474641 cctgtacaga cagcttattc tgcaggagat gaagactcct gatcaggcat atcgacataa 2474701 ccgctttgat atgcttctga aatgagcctt gttgtctcct ggctttcttg ttcatcataa 2474761 atatagcgtt ccggttcttt tttcatcatt ctgcctccca tcattataga ggtaggttgg 2474821 ctataatgac gggattttat gaaggaaatt ttaacaaact cctgctgcca cgcaagcttt 2474881 cgctttttca agcgcctgtt ccacctgttt gaatccggtg cccccggcgc tcattctttt 2474941 ttcaactgcg tagtaagggt ctaacacagt gtaaatatct tcttcaaata gtgtgctcgc 2475001 ctgctgaaac tcgccaaacg gcatatcgct taaatagatc cctctttcga tgcatgtgta 2475061 cacaagtttc ccgaccactt catgcgcttc tctgaacggc attccttttt tagctaaata 2475121 atcggccagt tccgtcgcgt ttgaaaagtc ttgttttgtt gcttgcttca tgacgtcttt 2475181 gtttacagtc attgtttgga tcatgcctgt gaagatttgc aggctgccct ccaccgtttt 2475241 caccgtgtca aacatgccct ctttgtcttc ctgcagatct ttgttgtaag cgagcggaag 2475301 tcctttcatg atcgtaaaca gccccatcat atcgccgtat acgcgtcctg ttttgccgcg 2475361 gatcagctcc gccatatcag ggtttttctt ttgcggcatc atgctgcttc ctgttgcgta 2475421 cgtatcgtca agctcgatga atttaaactc ctgcgagcac cataaaatga tttcttcaga 2475481 gaaacgggat aggtgcatca tcagcatact gctgttgctt aaaaactcca aaatgaagtc 2475541 tctgtcgctg acgccgtcca agctgttttc ataaatggca tcaaagccga gcagttccgc 2475601 tgaataatca cggtcaattg ggaaggttgt tcccgcgagc gccccgcagc cgagcggaga 2475661 tttgttaatc cgcttcattg aatcctgaaa acgctccttg tcgcgctcaa gcatccagaa 2475721 atacgcaagc agatggtgag cgaatgaaat cggctgggcg cgctgcaaat gtgtgtagcc 2475781 cggcagaatc gtttcaacgt tcgcttccgc cttttcaatc agcgcacttt ggaatgcctc 2475841 aatcagctcg atgatgtggc cgacatgatt cttcaagtat aaatgcatgt cagtcgccac 2475901 ctggtcattc cggcttctgc cggtatgcag cttgccgcca agaggaccga tttcgtcaat 2475961 gagcattttc tcaatgttca aatgaatatc ctcataatcg actgagaatt ccaatgctcc 2476021 ctcctctgct ttttgcaaaa gggtattcag gccctctcgg attttcaact cttcttctgc 2476081 tgtcagaata ccgcattttt tcagcatggc agcatgtgcg agagaccctg taatgtcttc 2476141 agcaactaaa ttttggtcaa atgatatgga cgcgccgaac tcgtcgaccc atttttccgg 2476201 tgttttttga aatcggcctc cccaaagctt cttcatgctt taatctgctc cttctttttc 2476261 acgatgctgt tcacttttgt cggaagtccc caaagctcga taaatccgat tgctgcatgg 2476321 tgatcaaatg catcgtcttt tgtatatgtt gcaagttttt catcatatag agagtattcc 2476381 gatttacgtc cttctacaat tgcatggcct ttaaacagct tcacgcggac aatgcctgtg 2476441 acatgctttt gcgtttcttt taagaaagcg tgcagcgcgt cttttaacgg tgagaaccat 2476501 aagccgttgt aaatgatttc tgacattttt tgctcgatga tcggtttaaa gtgggctacc 2476561 tctttcacca gtgtcaaatc ttctaattct ttatgcgctt tgatcagtgt catcgcacca 2476621 gggcattcgt atacttcccg ggatttaatg ccgacgaggc ggttttccac gtggtcgata 2476681 cgtccgacac cgtgcgcgcc cgccatttca ttcagcttca agatcagctc agaaagcgag 2476741 taggaaacac cgtcaatgga gacaggcacg ccctgttcaa atgcaatttc aatcacttcc 2476801 ggcgtgtccg gcgttttttc cagcggagct gttaaatcgt atgcaccttc tggcggcgcc 2476861 gcccatggat cttctaaaat gccgcactca ttggcgcgtc cccagaggtt ttggtcgata 2476921 gaatacgggc tgtcaagatt gatcggaatc ggaatgccgc ggctagccgc atattcaatt 2476981 tcttcttcac gtgaccactg ccattcgcga accggcgcga tgacttctag gtcagggttt 2477041 aatgatttaa tggagacttc gaaacgaacc tggtcatttc ctttccctgt gcatccgtgg 2477101 gcaatcgcct gtgcatcttc tttttccgca atttcaacca gttttttcgc gatcagcggt 2477161 cgagataatg ccgaaacaag cgggtatttt ccttcataca ttgtgtgggc ctgcaaagag 2477221 ataagcgcgt aatcctgtgc aaattcttct tttgcatcga tcacgtagga gtttgtcgcg 2477281 ccgacttcaa gcgctttctg ctgaacaaat gccaaatctt tgccctcacc gacatccagg 2477341 cagcaggcga ttacattata tccttgctcc tgaagccatt ttattgcgac ggaagtatca 2477401 agacctcctg agtatgctaa tacgactttt ttctgttctg acatgataaa aatcccctct 2477461 caaccgtgtt tctattttgt ataaaaataa attatattta ataaaaatac attttgtatg 2477521 tatacacttt aacaagtacg tttcgttttt tcaagccttt tataaaaaaa acttcaccta 2477581 aatttcaggt gaagtttcat agtatttatt catttacttg tcttttctga tttctctgac 2477641 cacatgcgca agttcgggaa taatcagctt attcattgcc agctttactg cgccgcttga 2477701 gcctggcgtt gagaaaacag cggtatgctg aatgacgccg gcagttgctc tcgacatgat 2477761 tgcggcagag ccgatatcct ctgtataact cagcatcctg aatatttctc caaagccggg 2477821 cagttctttc gaaaacagcg gcgttatggc ttcaattgtg acatcccgat ctgctatgcc 2477881 tgtccctccg tttaagagta ccgcgtctgt ctgttcatcc atgcagcccg caagcactga 2477941 ccgttgcaaa gcatcctttt cgtcttttac aatttcatat gcggcaatat gatgaccggc 2478001 ttcttctaaa aatgagatca tcagcttgcc gcttttatcg gtttcatctg tcctcgtgtc 2478061 actgacagta atcactttgc accgaacgat atcgggagct tcttgtttat gctcttgaac 2478121 gctcattggc ccacctcttt tatgttttct gtctgtcact atcatgcatc aacaaaaaag 2478181 cacattcaag agaatgtgct ttcatgcgat ttattttgct aaacgaacaa cgtcgcgcgc 2478241 aatcatgact tcttcatcag tcgggatgat catgactttt actggagaat gcggatagct 2478301 gatgaaagct tcctcgccgc gcacgttatt aagcgcaggg tcccagtata cgcccatgaa 2478361 ttctaaaccg cgaagaacgc gttctctgac ttccacactg ttttcaccga taccggcagt 2478421 aaagatgatc gcatctacac cgctcattct tgcagcgtaa gaaccgatgt atttgtggat 2478481 tctgcttgcg aatacttcaa gagccgtttc cgcgcgctca tttccttctt tcgtagcttc 2478541 aacgatgtca cgaagatcgc ttgagaaacc ggaaatgccg agcagtccgc tttttttgtt 2478601 taatgtattc agtacttcgt cagccgtttg gcctgttttc tccatgatgt atgggatcag 2478661 ggcagggtcg atgtttccag agcgtgtgcc cattgctaca ccggcaagcg gcgtaaagcc 2478721 catggatgtg tcaatagatt ttccgccttc aacagcggca atacttgctc cgtttccaag 2478781 gtggcaggaa atcaggcgca agtcttttaa cggacggccg agaagctctg ccgcacgctc 2478841 agttacatat ttatgtgaag tgccgtggaa gccgtattta cggatgccga atttttcata 2478901 gtattcatac ggcaagctgt aaaggtaaga ctgctcaggc attgtttggt ggaatgctgt 2478961 atcaaataca gctaccgcag gaacatttgg aagcacttct ttgaacgctt taattccaac 2479021 gatatttgcc ggattgtgaa gcggtgccaa ttcagaaata tcttcgattt ccttaatggt 2479081 ttcatccgtt aataaaacag aatcgctgaa tttttctccg ccgtgaacga cacgatggcc 2479141 aattccgtca atttcattca agtctttaat aatgccgaat tccgttaact tattcagcag 2479201 cattttaaca gctaccgcat gatctggaat atcagttact tctgtatttt tttcgccgtt 2479261 cacagaaatt gtgaatacgc tgtcggcgat accgattcgt tcaactaaac ccttcgttaa 2479321 aacggtttct gaaggcattt cgaaaagctg aaatttcaaa gacgagcttc ctgcgttaat 2479381 tgcaataatt ttggacatga ttgacgctcc tttatactct gtatcaacaa cttcgttttt 2479441 cgtacttttt tcccggtgaa tatcaacatc ttctccgaaa aatatctgac ttttccattt 2479501 aaacattgtc atgtcggctt ttcaagtcaa cttgcgtatt gataacgctt acaataagaa 2479561 gtcgttattt tcagacacat tcactatagg ttttgtattg atgaacgctt acaatttgcg 2479621 gtttttccct ctgtattttg tgtttcaaag ctggattcaa ttcgtcaagt ccggtcttca 2479681 aaagcataaa taaaagcagc ttaggcatcg acctcatacg gctgtctaag ctgcttttaa 2479741 aacacttact tttctttttt aaaccattca tcaaattgag ccatcatatc aagcatcgcc 2479801 ttttgattgg agaaagacgg aagattcgca agcagaattt gccccggcgc tttcgtattc 2479861 tctccttgtt tctgaagcac aaggatgctt ttggcatgag cttcgtcttt aaaaatagat 2479921 tttggcagct gcaacagtgc gttgatatga accttatctt tgaaaaactg tttcagcttg 2479981 ccgctttggg agctctcaaa caaatgattc ggaatcataa aaaataagta gccgcccggt 2480041 ttggtatgct tgacgctctg ttcaataaac agatgatgag cgaaggaatg gccttcgtca 2480101 gctttgagct caaacgcttc tgctccttcg tcattcggat aatagccgac tggcagatca 2480161 caaatgaccg tgtcaactgg atcgataaac aacggctcaa ggctgtcctg gtggaaaagc 2480221 tcaagctctt ttttcagaag gttcgcttgg gcataggcga tcttcaagag cacatcatca 2480281 atttcaatgc caaagctgtt tgccgttttt tcagacagct ggttcagcac ggtaaacaga 2480341 aggttcccag ttcccagggc tggatcaaga atggtcagtt cctttttgtc cgccataaat 2480401 ttattcacca aatagctgat gaaaagcccg atcgtatccg gcgtcatttg tctgtttgga 2480461 tgcgagatat ctttcattcc tttaaggacg gcaagctgaa aagccttgcg tacccactca 2480521 tgctcatacg tgccgaattc cgctttttca agcagagcct gaagttgttt ggttttctga 2480581 tcagcaggca gtttcagctg atccgttttt tcaagaaaat acatttctcc tgcttcggcc 2480641 agcgcctcta tatatgaaat ctgcaattca ttctttatca taatcgcggc ttcgtttaac 2480701 agctcataca ccgcacctac atggtctttt tgcatattgt gttcctcctt gccatgaaaa 2480761 aagctccggc ggcagcctgg agcttttttc cctgcttact ttactaatgc cttagcagcc 2480821 tcaattggct tttcatagtt cgggtggttt gttgcttcgc ttacatattc agcgtaaacg 2480881 acttttccgt tctcatcaag gacaaatacg gaacgcgcaa gcagacgaag ttctttaata 2480941 tacacaccga acgcttcgcc aaatgacata tctctgtggt cagacagtgt ttccactttg 2481001 tcaattccgt tagcgccgca ccagcgcgct tgcgcgaatg gaaggtctgc actgattgtg 2481061 tagacgttga catctccaag ctttgcagct tcttcgttaa aacggcgtgt ttgtgcatca 2481121 caaacacctg tatcaattga agggataaca gaaataatcg ttacctttcc tttcatgtca 2481181 gctaacgatt tttcttcaag gctgttagtc agcactgtga aatcaggagc ttgatctcct 2481241 accttcactt cttgtccgac aagtgtaacc ggaccgcctt tgaatgtaat ttcagccatt 2481301 ataattcctc ccttttgtat gtatgtctct atcatagtaa agtttcctgc aaactgcaaa 2481361 gtttatgcca aaaaaaagtt aactgcggcc agcgcagtta accttttttt aataattcat 2481421 attgttcatt tggttttgat tttggccttg gctttggttt ttgttatttt tcttgaacat 2481481 ttgctggatg cgctcgagtg tttgaggggc tgcgtctaaa attttctcta ttaaatgggt 2481541 attttcatct aaatgaagca ttctgatgcc tgtcgatccg acaattaaaa acgcgatcgg 2481601 cgtaatggac acaccgcccc cgcttccgcc tccgaaagga agtttctgtt ctcttgtctc 2481661 atcgtcttcc gatttctttt cggccggctt tccgccaaac tcgcttccgc ctgcggcgaa 2481721 tccgaatcca actttagaaa cagttaaaat cacacttcca tcaggcgttt ccactggatc 2481781 tccgatgatg gtgttaacat caatcatttc cttcaagttt tccattgcgg ttttcattaa 2481841 accttggatg ggatggtctg ccatatacgc ttcctcctta aactgatgaa tcattctttg 2481901 aagtcattct agccgacgga ttcttcttta atacggatag ctcccgtccg tatttgacga 2481961 atttgaaagc tgcaagcata gcatgtccaa agcgaaaaaa gaatatacac tgaaaatggg 2482021 tcttggaaac agggacttga aacgacggga tcacctcata gacaggttta ttcacaaagt 2482081 ccaggtggtc gtagagcatt gctgcgatac cgcccttcac gccccataca gcaccggtta 2482141 acacacctgt cactgccgcg tcctgaattc cgattactgt aacccattct agttttgtga 2482201 tatgtaaatg cgcgagaaaa gacgcgctga ttttccgcag tctggtgacc tgatgcaaaa 2482261 gcatttcgat tttattaatg ctttgctgca catcgttttg tgtaattttt ttctttccgc 2482321 tgcttttttt cattttggat tcagtttttt gtttgatatc cactgttccg tcttctttgt 2482381 tcaccttaat cgccgggatt gtttttttga tccttataag gccaaacagc gccgtaatct 2482441 tcaaggtcaa tttgtcatta tcatcggcat gaagatactc cagcgcgaca tggattttca 2482501 ttctgagaag cagtacgatc cctatgagaa taagaatggc tgtcagtaca tacaccatat 2482561 tcttcacttc ctctaggagc attatcgcca attcctaaaa aaataaaccc ggacggaagt 2482621 ccgggttatc ggttatttgc ggtataattt ttcatgcacc acggtggtat ccgcgatgta 2482681 atcatgaatc ccttgttttg taggtgaaaa ggcaacaacg atatataaaa tccaaatctt 2482741 atcaatatac cgtccaacca cttcacgaaa aatcactgta ctccatgtca gcttgctatc 2482801 ttgcttcaca gaaaccactt tgaggccgaa caccatttta ccaagcgtct gcctgaagta 2482861 ttttgtcatg agtgcgaaat aggcaagata cacaataagc gttgtcacac tgtaggccga 2482921 gaaggtaaac atgccggatg ttttcggcag atccaatacg gtaaagaggg gagaaacgag 2482981 caaatggttt aatccccata tcacgagcca atcaagcagg aaagcccaga aacgaaccca 2483041 aaagccagca taggcatgtg tcagcagctc cgcttcttgc gggcctttga tgtcattgcg 2483101 ctctaactct tcatatgtcg cgtccattat tgttccctcc tacttcgcat agagatacat 2483161 cattctcggc gaaccggatt gcgatagaat ttctctcata ttcaaaaaat caatttcact 2483221 tttaaacatt ttgttcgcgc ccatggaaaa cagtgagcct aatccgaagc tttcctcata 2483281 agaaatgaca gaggcgtttt tcaaatcctt gtgatccttt ttcatggccg taatggtatc 2483341 gtcataaaaa ccaagctcat caacgaggtt cagttttttc gcctgccgtc cgtcatacac 2483401 gcggccgtcc gcaattttct ttacctctgc tttcggcatg ccgcgccctt ttgaaatgac 2483461 atcaacaaag ccttcatacg aattatcaac catcgattgc atgatgtttt tttcttcttt 2483521 cgtcatctca cgggaaggag acataatgtc cttatgggcc ccgctcttaa tcgtttcaaa 2483581 agaaatgcca agcttgtcgg caagctttga ataattgacg ctttccataa tgacgccgag 2483641 tgacccggtc agggtttccg gtgtcgcaaa aatcttatca gccgctgttg agatgtaata 2483701 gcctcctgat gctgccatcg aacccattga cacgtaaatc ggttttttcg tttctttctt 2483761 gatttcttcc agtttcttat gtatttcagc actttcatac actccgccac ccggagaatt 2483821 caccttcaga acgatacctt tgaccgtctt gtcatctttt gcgcgctcaa ggttttttaa 2483881 gaacgttctg tggttatatc cgtctgcacc aagcagactg cttgagtccc cattatcctg 2483941 aatggtgccg ctgacctcta atacggcaat tttacttgag ggactgccgt tttccagcgt 2484001 cttctcctgc gattcatccg tcagtgatgt gagatccgtt tgagcgcctt tgacgctttc 2484061 aaagaaactc atagagatgc tgacgataat agacacgccg aaaatcccca gagcaatcac 2484121 taatgcaatc catctttttg cattcatttt ttctcctcct ttttcctaaa ctctctcatt 2484181 atacgattca atatgaaaaa tgtttcactt catgagaaag ctccggctta acgggctgcc 2484241 ggcaaacgtg gtacacttat ggccaaaggt attttatcac aaatactgga tggcagaaaa 2484301 acttaaatat gacagcaaag gggaaatggg atatgaccga tcaacgccgt aatgtttatt 2484361 tttttcacaa acaggatcag gaaacgaacg aacaagcccg ctcgttaaca caattagcgg 2484421 aagagcatgg atttaccgtt gtgaaccagc actcagacgc caatattatc gctagcattg 2484481 gcggggacgg cacatttttg caggcagtca gaaagacgaa ttttcgtgac gactgcttgt 2484541 acgtcggcat taccaaaaag gggaaagctc atttatattg cgactttcat agtgatgagc 2484601 gagaaaaaat ggtcgatgca atgacgtttg aacaaattga agtgagaaaa tacccgctga 2484661 ttgaagtgac agtggatcaa gccagtcctt ttcactgctt aaacgaggta tccatccgct 2484721 caagcatcat caaaaccttt gtgatggacg tgctgattga cgatctgcac tttgaaacgt 2484781 ttagaggtga cggaatgatt atctcaacgc ctacagggag caccgcctat aacaagtctg 2484841 ttgcaggagc tgttgttgat ccattgcttc catgcatgca ggtatcagag cttgcatccc 2484901 ttaacaataa tacctaccgg acactcggct cgccatttgt cctcagctct gaccgaaagc 2484961 tgacccttcg tgtggtgcag gacggcaacg aacacccaat catcggcttg gacaatgaag 2485021 cactcagcac gagaaatgtg aaaacgatcg aaatcaaact gtctaataag aaaatcaaaa 2485081 cagtcaaact aaaggacaat tcattttggg aaaaagtgaa gcgtactttt ttatagaaaa 2485141 taaaaggaca ggctgctgcc tgtcctttta tgatttctca tatacaatct ggccgttaat 2485201 cacggttttt ttaatctcta aaagatgaag ctgtgcgggg tcaatggcaa acggatcacc 2485261 actgagaact gtaaaatccg cgtcatagcc ttccgcaatt tttccgcgtg acttctcttt 2485321 ataaatgata ccggcgctac cttctgtata aagctttatc gcttcatata caggtaaaca 2485381 ttcactttca ttatagcttg gcccgttttg ctcatgactg cttttccgga ggaccgcgga 2485441 ctggatccct agaagcgggt caacaggctc aatcggggcg tctgaaccgc ccgcgcataa 2485501 aatgccttta gatatgaggg ttttccaggc aaatgcagtc ttcatccggt cttttccgag 2485561 acggtcaatg acccacggaa agtcgcttgc aacgaagtgc ggctgaaggt caagtgcgat 2485621 cggcatgcgt gctgctctct cgattaattc gttatcaagc acttgagcat gaataagccg 2485681 atcatgccgg ccgtttttgg gcggatgctt ttctattgcg ttcagcactt tttcaaaagc 2485741 aagatcgccg attgcatgaa cagcaacctc catccctttt tctctcgctt tgcgaatgag 2485801 ccggccaagg gtttcgtcat cgtgaacctg aacaccattt gttgatggat catcctgata 2485861 tggttctttc aataaagccg ttctcccgcc aagcgccccg tccgcaaaga ttttcatagc 2485921 accgaactcc acatacgggc cggacagctt ctccagctgc tcccatcgat cgacagcttc 2485981 atgatgaacg agcaaatggc agcgaaacgg atactttccg ccagcggcag ctttctcata 2486041 agctttcatc ggcaccgaaa catcaccata ataggacaag tcttccgaat gaccgcccgt 2486101 caggcctttt gtccagcaat cctttattgc agccgttaat gcctcatcaa catagtgctg 2486161 ggagactggc gggacagcct tcagaatcaa atcctgcgcc ttatcaaaca ggagtccggt 2486221 cggctcgcca tttgcatctt ttacgatgac tccgccgtca ggatcaggag tatttcttga 2486281 aattcccgct gcttgaagag ccgcagaatt gacagctatt gcatgccggc atatacgctt 2486341 gagcaagacg ggcctgtcag gaaacaggcg atcaagatca tgcttagtca agtagtcagg 2486401 tgtctcaaac tgattttcat tccagccttc tccaatgagc caatcgtttt taggaagctg 2486461 ccgctctctt tccttcgcag cctgtaaaat tgaatctttc gacgtcagtg cggacagatc 2486521 gagctgaagc tgtttctcac cgtggccgat caaatgtaga tggctgtcaa caaaaccggg 2486581 gaacatcact gctccgttca ggctgatttc ttctgtttcc ggcgacccgt acttttcctt 2486641 caaacgttca tagctgccgg tgccttttat aacaccatcc tcaacataaa ctgcctcagt 2486701 ccgatcgcct tcttcgagca tcgtataaat gaaaccgccg tgccatatcg ccttcattca 2486761 cgttcactct ctttctttac gcctttttat tggctttgag ctgttcttca cgttttctta 2486821 attccactcg tctgattttt gcagaagccg ttttcggcag gctttccaca aattcaattt 2486881 ctctaggata tttgtatgga gcggtaatcg tcttcacatg gttttgcagc attttgacaa 2486941 gctcatcact gcgtttttca tgattttgca ggacaacata tgcctttacg atggagcctc 2487001 tgatttcatc agggcttgcg acaacagcac attcttttac ttctgggtgc ttaacaagcg 2487061 cgtcttccac ctcgaaaggc ccgatcgtat agccggagct gataataata tcgtcatttc 2487121 ggctttcaaa ccagaagtaa ccttcctcat cttttcttgc tctgtctccc gttaggaaat 2487181 aatcgccgcg aatttgtgtt ttcattcttt ccggatcttt aaaatactct ttaaagagcg 2487241 caggcgtact gaggtgaaca gcgatatcgc caacctcacc aggtttgcag atttcaccgt 2487301 cttcatttat gatctccacc tgatttcccg gtgtcggttt tcccatgctt cccggtttaa 2487361 taggcgtatc tttcaaaaca ccaaccaaaa gcgtgctttc tgtttggcca tatccgtccc 2487421 gtaccttaat gccaaagtgc ttttggaaaa catcaatgac ttcacggttg agcggctcac 2487481 ctgcggaaac agcgctgtgc agggcagaaa gatcaaagcg tttcaagcct tcaaccttcg 2487541 ccattaagcg gtattctgtc ggagtgcagc agaaaacatt gattttgtag cgatttaaaa 2487601 gctctagata tttttctgct ttgaatctgc cgtggtacac aaaaccggtt gctccgctgc 2487661 caagcaccgc taaaaacgga ctccataccc acttttgcca gccaggggca gcagttgccc 2487721 agacgatatc cttttcagaa atgtcaagcc aagcgccggc agaagttttt aaatgagcaa 2487781 atgcccatcc atgtgtatgt acaacacctt tcggctgacc tgttgtcccg gatgtataag 2487841 ataagaaagc catatcatct cttgttgtgt cagctgtttt aaattggctt ccgtccgctt 2487901 caattgataa gaggtttttc cagccggcat cattttcacc aatagacagt gtaatcagtt 2487961 tgtcagccgt actgacatcc cggaaagcgc caataaattc ggagtagacg atagcgcctt 2488021 ttacctctgc atgttcaatc cggtattcaa gatctttcgc gcgaagcatt tcggagcacg 2488081 gaatgacaac cattcctgat ttcaggatag ccaaataaac agcataggct tcaagcaccc 2488141 gcggaaccat tacaatcagc ttgtctccct ttttaaatcc aagatcagct aaggccgctc 2488201 cgattttatt tgtttcttcc atcagctttt catacgacca agattcttgc ttgcccgact 2488261 cgtcctccca aagaagagcg gttttttgtc cagcagcact gaacttttcc atttcattca 2488321 ctaaattata ttgcacaggg gcaattaaat cttcacgttt taacacgaac aactcctcac 2488381 tttctccacc cattatacat aaatacaggc tctttccgta aggatatgcc taaaagcaac 2488441 ctctgtaaac atagatttta taggccgctg gtcctttttt atatgtaaaa aatgaaaaag 2488501 agtggggata cccccactcc taagccatta tgtgaaattg taaattagaa ttgtcctccg 2488561 cccatgtttt gttgagcaaa agatacaaga cgttttgtga tctctcctcc aacagaaccg 2488621 ttagcgcgag aagttgtgtc tgctccaagg tttacaccga attcagaagc gatttctaat 2488681 ttcatttggt cgatcgcttg agcagctcct ggtactaaaa ggttgttgct gttacctgag 2488741 ttattgttag ccatgtgtct cacctccttg tgagtataga atgtgtcaaa acacatggct 2488801 tcattcagaa aaactttggt aattgtatac aggagctgaa aattgattta aaagagttca 2488861 gcgaatttat cgttagcttc ttgttcgcta taaagggtca ttgtctcaat gttatctacc 2488921 gcttcttgaa tatacggctc gaaatcaaca aagctttcaa agtgttcaat tttctctttt 2488981 ttagggcgtg ttttcgggct tggcggtgta aagatcgtgc agcagtcttc aaacggctga 2489041 atacttgtct catatgtgcc aatttcccgt gatttttcga tgatttctgt tttgtccatg 2489101 gcgattagcg gacgcaaaat cggtgttgac gtcaccgcat taattgcata catgctttca 2489161 agcgtttggc tcgctacctg accgaggctt tctcccgtaa taatggcaag cccgtttctc 2489221 ttttctctga ttctgtcggc tatctgaagc atgaggcggc gggttgccgt cattgtgtaa 2489281 ttttcaggaa tttgtttttg gatgagctct tgcgtttttg taaatggaac aatatgaagt 2489341 gtcatgcttc ccccaaaacg ggacagacat ttcgccagat ccattacctt ttgctttgcg 2489401 cgctcgcttg tgtatggcgg gctgaagaaa tgaacagctt ctaccgacaa tccccgtttc 2489461 atcgcataaa aaccggccac agggctgtca aaaccgccag aaagcatcag catcgctttt 2489521 cctgctgaac caactggcag cccgcctgca cctttttcat cacgaattgt caaaaatgtt 2489581 gcttcttccc tgatttcgat tctgagcggg atgtctgggt tgcgaacatc gaccgtcaat 2489641 ccttctgtat ttcgcaaaat atggccgccg atttcagcgt tcatctggtt tgtatctaat 2489701 tcaaattgct tatacgctct ctttgtcgcg actttaaacg tatcacctgg tttatactga 2489761 tctttgatag cctttagtgc ggttgcctta atatcatcaa ggcggctgtc acacttaatt 2489821 gccaggctga agctttgaat cccaaacact tgctttaaat gaggaaaaag agcctcagga 2489881 tcctctccat ttaatgtaat cgtcatacga tccctgttgg aaaagtattt taaattcgga 2489941 tagtctttca aaacgagtct gatgttttgt tttaagcgct caataaagct ttttctgttt 2490001 ttgcctttgg tcgaaatttc cccaaaacga attaatatat gatcgtaatt catgttctac 2490061 ctcatcattt cccttaattt tttgatgcca ggacgaagcg cgttcataaa cggttctgcc 2490121 acatcgcttg tctggctgta atttaaactg attctgatgc tgcttccggc aatctgctct 2490181 cctttgccca tctctaagag aaccttgctg ggcttatgtt cttttgccga gcaagccgat 2490241 gttgtggaga cgaatatatc ctgttcctca agcatgtgta aaagcacttc cgctttaatc 2490301 cccggtacag agaaattaat aatgtgcggc gcgctattca tttgaggcgt gttgataacg 2490361 acgccctcaa tttcactcag cctattcata aacaattcct ttacggcagt catcgtgtca 2490421 agccgtgtgt caaaatcagc agaggccaga ttaatggcct tggcaagcga aaccgcacca 2490481 gcagtatgtt ctgttccggc ccgtatgcct ttttgctgag agcctcccgt tatgagcgga 2490541 ataaggcgtg ttccttcttt tacaataagt gcgcctgtcc cctttaggcc gtgaaattta 2490601 tgccccgaaa ttgaacatag atcaatgccg gccttttcaa ttgccaaggg cactttatag 2490661 atgccctgca cataatcgac gtgaaacaaa atgttcgaat gctctttcag cacttctcct 2490721 gccgcttcaa tcggctgcac ggaaccgact tcattgttca catgcatcat gctgacaagc 2490781 acggtatcgg gacggatggc tgcttttaga tcttcaatag aaacaaatcc gtcttcattc 2490841 acagaaagat aagtgatatc aaacccgaac aactctttca gctgttctaa cgattccgta 2490901 acggatggat gttcaataga agtggcaatg atatgtttgc ctgtttttat ctttgacaaa 2490961 gccgctcctt ttaaagccgc attattggct tctgtggcgc ctgacgtaaa tacaatatca 2491021 tattttttta ggcctaagga ccttttgatt tgatttttgg ctgcttgaag cagctgttcc 2491081 gtttcggctc catatcggtg caaagatgaa ggattgccaa agtatcggct gctcgtctgt 2491141 tcatatacgt tcaagacttc atcgtaaggc ttcgtcgttg aactattatc taaatatatc 2491201 atctttttta ctcctttatg aaagcggtac aaggtatgat atttatgtta ccataacaaa 2491261 atttaataga aaattacgaa aaactagtat tgacttctaa tttttttacc atataataag 2491321 atttgttcgt ttcgtcatat tatctgacaa ttaattgaca gaatatttta acataattat 2491381 taggaggatt tttttcatga aacactcact gcctgtcaaa gataccatta ttattggttt 2491441 catgctattt gcgttattct ttggagcagg aaatatgatt tatccgccgg aacttggaca 2491501 agcagccgga cacaacgtct ggaaggccat cggcggattt ttactgacag gggtaggcct 2491561 gccgcttctc ggcattatcg ccatcgcatt aaccggtaag gacgctaaag gccttgctga 2491621 caaagcgcac cctgttttcg gcacaatctt tactgtcgtg ctttatttat caatcggacc 2491681 attattcgcc atcccgagaa caggaactgt ttcatatgaa attggcgctg ttccgttttt 2491741 gactggtgta ccagaaagac tttctttatt aatatttaca cttatctttt tcggcgttac 2491801 gtactattta gcgttaaacc catctaaggt tgtggatcga gtcggaaaaa ttctgactcc 2491861 catcaaattc acaattattt taatcattgt tctcaaagcc atcttcacgc cgatgggcgg 2491921 attgggcgcc gtgacagaag catataaagg aacaccggtt tttaaaggat ttttagaagg 2491981 ctataaaaca atggacgcac ttgcttcaat tgtatttggc gttgtcgttg taaatgctgt 2492041 aaaaagcaaa ggcgttacac agtctaaagc tcttgctgca gcctgcatta aagcaggtgt 2492101 gattgccgct ttaggcctga ctttcattta tgtatccctt gcttatttag gtgcaacaag 2492161 cacaaatgcc attggtcctg ttggtgaagg agctaaaatt ttatctgcgt cttcccatta 2492221 tttattcggt tcattgggca acatcgtact cggagcagcg attacagtcg catgtttaac 2492281 aacaagcatc ggccttgtca catcttgcgg ccaatatttt tcaaaactta ttccggcatt 2492341 atcatataaa attgtcgtta cgattgtcac gttattcagc ttgatcattg cgaatttcgg 2492401 actcgcgcaa attatcgcgt tttctgttcc tattttatca gctatctatc cgcttgccat 2492461 tgtcattatc gttctttcct tcatcgataa gatctttaaa gaaagacgcg aagtgtacat 2492521 cgcatgcttg atcggtacag gacttttcag tattttagac ggtatcaaag cagccggttt 2492581 ttcacttgga tctttagatg tgtttctaaa tgcgaatctt cctctttaca gcctcggcat 2492641 cggctgggtg cttccaggaa tcgtcggagc ggttatcggc tatgtgctga ccttattcat 2492701 cggaccatcc aaacagctta atgaaataag ttaatgtcac agaacgcctg cgttattgcg 2492761 caggcgtttt gtaataaaaa aagagcctgc tcattacact gcgggctctt tttcatggtc 2492821 gtgattatct aagcggatat gtcagctttg attttttcaa ctgcacctgg cgcagccttt 2492881 tctacagcgg cagcggcaat ttcataagag tcgtcataat caaaagcata aaaacgtctt 2492941 tccgcttctt tcagctgttc agataaaata tgattctggc ttctgaaccg gtttccgaac 2493001 tgaatgattt tttcaatgag gatgacctgc tcgacaagtt cctctgattc ccggcttgcc 2493061 ctgttgacga tatcttctgc ttgtttcaaa tgggctccgg cttcttccat atttaatgga 2493121 agttcgttta gttgattgac cgtttcttga atatgatgat gcgcgttctc cagcatctct 2493181 tgaatatggc tcggaatgcc tggaatgttg ctagtcttca gcagtcttgc tgtctcagaa 2493241 attgtttttt tcaaattgct gagcgtctcc ctcgcctgaa gctcttcttt tctcagcgct 2493301 tgcagatttt cacgatactc ggcatgctct tttttcactt cttcaatttg cttctctatt 2493361 gaagcaactt cttctactaa aagtgagtag gcgacatgct ctgcatcaag cttatcttta 2493421 acggatgata gcagctttcc aatttcatca aggcgctttt caaaagcctg ctgtttgccg 2493481 agctcaccgg ctgtcagcct gtagctttcc ttcaccagct cagtttccgc tttcgtatgc 2493541 tctttctctt ctttaagctt gtcgtaagca ataatcaatt caggcatttt gcttagtacg 2493601 gattgaccgg cttcaacttc gccctccagc tgctgataaa cagattgaat attttcgtca 2493661 atgagctgca ggattgcgga cgcttcatca atatccagtt cagtcatcag gacatgttcc 2493721 gctcgtttca gctggtttga cagattttct aattccttat caagctggat atgctcaagc 2493781 ttgtaccctt tttctttcat ttcgccatag ccatccttga gctttgcaat ctgtccgggc 2493841 accgtctgtt tacagtcagc taacagcttc ggcacatcat ctatgtatga ctgaagccgt 2493901 tcaagattgc ggtcctgctc aagcagtact tttcgtgcag taatatagtt tccgccttct 2493961 gtttcttctt caaattgttt gatgccgctc caaatttcgt ccagatcctt ttcaaggctg 2494021 tcataaagct ccccgtaaag gtggctgtaa gccagcaggt tttttcgaga tttcgaatag 2494081 cgctccctca cctgttcaat ctcttcacgg ctcttttcct cacttgtgac aagatcgctg 2494141 atttcccgaa gaatcttttc aatgcttgat tcagccgctg tcagcaggtc gtcgatatga 2494201 acgagcactt gattggcctt tttaaaccgg tatttgtctg cattttcctc ggcatcataa 2494261 aggagctctt caactttcgg catgtgggct gtgacaatct catcccattc ttcacgccac 2494321 ttctcaaaga actcttctgt ctgacccgtc atttttaaat gttttatttt agacatttct 2494381 tccacgatcg accgattcag aatttcaatc ttccacgatt ccagccggtc gatttcggcg 2494441 tagatttttt tcctgaaaaa gtagcctgcc gcaaacagcg caagcagtac aattaataat 2494501 ccaatgacaa actccataat gagccccctt gctgtttacc ttaatctgtc agggtgtttt 2494561 atttattcag aaagatttca ggatatgtat tgagaaaaac tgtcgttttc attgttatta 2494621 tgataccatg taacaaacat tttttgacca gaaatcaaaa actttttgtg caaaatcggc 2494681 aggatttgac tattttttca tggggtgaca tcaatgcaaa agcgagacgg acatattcac 2494741 acaccatttt gccctcacgg ctccaatgac acactcagac aatatgcaga agaagcctta 2494801 aaaaaagggt tcgaatcgat tacttttacc gaacacgccc cattgccgcc atcttttacc 2494861 gatcccacgc cgctgaaaga cagcgcgatg gcgcaagctt ctttggaacg ctatattcat 2494921 gaaatttccg gattaaaaaa agaatatcgc ggacagctta gcatacggac agggcttgaa 2494981 gtcgattata tcgctgaatt tgaagacgaa attacattat tcctagacac atacgggcca 2495041 tatttagatg acagcatctt atccgttcat tttttgcgca cagactcttc ctatctatgc 2495101 cttgattatg acgagcatac cttcaaagag ctgatttcag cctgcggaag cattgaagcg 2495161 gtatatgaac aatattaccg gagtatctat tcttccattg tagcatctct cggcgtttat 2495221 aagccaaaaa gagtcggtca catcacactc gtccaaaaat tcatcaagct gtttccatac 2495281 agcatgtcag agcatattcg cggcctcgtt tctctgtgcc tgaatgccat tgaagaaaac 2495341 ggaatggagc tcgacttcaa tacttccggc ttaagaaaaa cttacgctgg cggtatttat 2495401 atcgaggatt ggatgctgaa tgaagcgaag caaaagaaga tcccgcttgt gtttgggtct 2495461 gatgcccatc aagcgggaga tgtcggatat gcgtatgagg cgtttttgga acggtgctag 2495521 ttggtgagcg ccacgtctcc tgtccggaag acgcttctga tccaaatctt gatttcttca 2495581 aaatacattt tataaaaata cggctcgtgc ggctgcatgt agagtacttc tgaaatatat 2495641 tgaggctgga gatagggcat catcaagaga gattttaatt ggagaataaa atgaggcagc 2495701 ggcagcgtta aatattcacg ctgtttttct ccttcctcaa tgatcagctg gaagatatac 2495761 ttttccttca ttagatatgt cgacataatt tccctgatta atgtggagtc aattgtgact 2495821 tcccggtaga caaaacgagt taattgacga tgattatgct gataggataa aatatcgaaa 2495881 accaattgaa gaagctgttc ctgcgtgctt tgagtagaga tattgcttgc cgctgtttca 2495941 agcgttttgc tgtagccttc gtaaaactct gaaactaagt gttccatcaa gcctcctttg 2496001 cctttaaaat agtaggagat gtgcgcaaca tttacatcag ctgactttgc gatttcacgg 2496061 acagacgtgc cagaaaatcc tttttggtta aaaagcatga cagcagattc aataattttg 2496121 tctttggtgc ttactttcat acggctcact ccttcctctt gatactattc aagcagaaag 2496181 ccgctgttcc tgtaagaact tatcgacaaa tgccggcaga aaagccggaa ctttgtttta 2496241 tattatagaa aaagtgaggg ttttccatgt tccatgtcga aaaacaatct ggagataaag 2496301 aaaaagacta tcagcttctg ctaaaacagc tcgaagccat gaccgaagac gaaacagacc 2496361 aaatagctaa ctatgcaaat gcctcagcac tgctgtatca ttcgctgcct gaagtcaact 2496421 gggcgggttt ctattttgcc aaagaagagg atggacagct tgtgttaggt ccgttccaag 2496481 gcctgccggc atgtgttcgg attcctttcg gcagaggggt ttgcggcaca gcgtacgcaa 2496541 acggaaaagt ggaacgtatt gaggatgtaa acgcgtttcc gggacatatc gcctgcgatg 2496601 cagcgtctca atcagaaatt gtgcttccga ttcgtgtaga cggaaaaatt gtcggcgtct 2496661 tggacatcga cagcccagtg aaaaaccgtt tcgacgaaat tgatgaaaaa tacttaactc 2496721 aatttgccga aacgctagaa aaagcgttag cgcagtaata taaaagccca aaactgatat 2496781 cgttttgggc tttttttatt ttattgagtc atgaatcatc aagcggtttt tcccgctccg 2496841 tttcgcgctg tagagcgctt catctgcctc atgcacaagc tctttcagcg acttttttgt 2496901 ttctgtcgtc cagcaggaga taccgcagga aatggttacc tcgggtttcg tattttttct 2496961 gaccgcgtaa accagtcgct cggtaatccg tttccccact gcaaccggca catttggcaa 2497021 ataaatcgcc agctcctctc ctccccagcg ggcaccgaca tcatgctttc ggatgttgct 2497081 tttaatcact gaagcgactt gaattaaaat ctcgtcccca gtctgatggc cgtacgtatc 2497141 atttacattt ttaaaattat caatatcaac aagaataaaa acaccctttt gatggatttt 2497201 catgctgtat tgaatttttt catctaaata cgctcgtgaa tacagttcag tcagctgatc 2497261 tgttttcacg agatgctcaa ggcggtcgcg aagcattgaa ttggttacag ccagtgtcgc 2497321 gtgatgaatc agcgcctgaa acagcttgta catttcaaat gtaaaagcgt acagctcctg 2497381 tttcaataaa accgcaaagc ctaaaagccg gtcgttttga atcatcggag cagccatcag 2497441 cgagccgtac cccgccttcc caaaaacaga ctggccattc ccgatgaaaa cccctttttc 2497501 accttcatac agcttttctt tcagctcatt ataaaaatct gacggcttcg cttctttaaa 2497561 aaatgctgtg ctgcctggga gcaatgttag gttttcaaaa tggtctatat gaaaaaatcc 2497621 cacttcttct gcctgaaacg attctgccat tctcacagcc agatcattca ttgtatcagt 2497681 caatgtcagc cgctgattca ggcgtcgtga tgtttcatta atcaattcca aatttgcgat 2497741 gcttgctttg gattgttcgt agagctgggc attttcaaac gcttttcccg cggcgtttgc 2497801 taacagcgac atttcatcaa ggcaggcatc agtaagaaag ctgtcacccg ttccttcagc 2497861 cttcaacacc ccgtatgtgc cctgctgtcc tttgatcgga atataggcga cagattcatt 2497921 tttccgcaaa atgtctccgg acaaatacac tttgagcgca aaggaatcgg atttttcccc 2497981 ttccatatac agctcttttg caggaatccc taaacattgg tcttgatcgt gcgatataaa 2498041 taaagaaaac tcaaaaagag aaaatgtgct tgtcaagctt tctaaaagct gcttcagcac 2498101 atctgtctga tcaagcagtg aatggaacag ctctgtcatt ttgtatatct ttttttggta 2498161 gatcgttttg ttatagagtc tttcctgttt catcgactgg tttaaaaatg aagcaaccac 2498221 gtccggaagc ccttcaggaa tctcttcatc ctgcctgcac gcaagatgga aacgcctgcc 2498281 ggagccgtcc tcaatcagat aacatgaagc gtttattttt gaagcggaaa aacgcgcttc 2498341 accatctgcc agttttgtca caaagtctga tggtgacggt gtaagcgaaa cacaaagggt 2498401 tgaaaaatag gtttgaatag ccgaagtcag ccatatgaaa gagtcggtga atgtgacttt 2498461 ttcagatttg gttaataaaa aatcgagcat atgataatga aaggcggata attgatcttt 2498521 agtttgttct accatgtttt tatcacctaa aagtttacca ctaatttttg tttattatat 2498581 cataaacggt gaagcaataa tggaggaatg gttgacttca aaacaaataa attatataat 2498641 gacctttgtg tgaaatattg cagccttttt gttcagcttc tatgttttca ttttgttcct 2498701 tatcaataag gtgtatcgtg taactctctg ctgctggagc gaggatacat gaaaacaaaa 2498761 tgtgcatggt cgaatagagc agacggtttt tattttccac aaaaataaaa ccaaaggagg 2498821 agtcacatta tggctcgcta tacaggtcca tcttggaaac tgtcccgccg tctaggaatc 2498881 tctcttagcg gtacaggaaa agaattagaa aaacgccctt acgctccagg tccacacggc 2498941 ccaggacaac gtaaaaaatt atcagaatac ggtttgcaat tgcaagaaaa gcaaaagctt 2499001 cgtcacatgt acggtgtaaa cgaacgtcaa ttccgcactt tgtttgacaa agctggcaaa 2499061 ctagctggta aacacggtga aaacttcatg attcttttag attctcgtct tgataacgtt 2499121 gtgtacaagc taggtttagc acgtactcgc cgtcaagctc gccaattggt taaccacggt 2499181 cacattcttg tagacggaag ccgcgttgac atcccgtctt acctagtgaa acctggtcaa 2499241 acaatcggtg ttcgcgaaaa atcaagaaac ctttctatca tcaaagaatc tgttgaagtg 2499301 aacaacttcg ttcctgaata ccttactttc gacgctgaaa agcttgaagg tactttcact 2499361 cgtcttcctg agcgttctga acttgctccg gaaattaacg aagcgcttat cgttgagttc 2499421 tactctcgtt aatcgtttta aaaacccctg ccgctatgcg gtcggggttt ttttatcggc 2499481 tttcgcctct tgctggccaa cactatcttg cgcctgctgc tcccaatgat cccgctgcag 2499541 ccgttctttt gcaatcgtac acatgagatt cacgctttag cgctcctttc atttaaaagg 2499601 tggtgattgg tcgtgtttgc cctatctaat atactctttt cctttcattc ctatgcggta 2499661 aacaaaaaga tcctttgcct tcagtggcaa aggatctttt tcttatttat acgtcacaag 2499721 gaagtatttt ttcttcccgc ggcgcagaac agtaaattgg ttttcgatgc ggtcttcacc 2499781 tgatagggta taatttattt ccgtctggcg ttcaccgtta atgtaaacag ctccgttttg 2499841 gatgtcttca cgcgcttggc gtttagaagg agataattta gattgcacca acacatctac 2499901 aagtgaaagc tcttgggtgc tgtcaacttc catagaagga acatctttaa agcctacttt 2499961 tacgtcttga gcagaaagct ctttaatatt gccgctgaac agcgcttggg agatgttgat 2500021 ggcttgctcc agcgcctcgc gtccgtgaac aagtgatgtc acttcttctg ccaggcgttt 2500081 ttgcgcttca cgtttttctg gcgccgtttc tgttttttca gcgtatgctt caatttcctc 2500141 ttttgaaagg aacgtgaagt atttcaagta tttgacaacg tcacggtcgt ctgtgttgat 2500201 ccagaattga tagaattcat atggcgatgt tttttcttta tcaagccaga tcgcgccgcc 2500261 ttccgttttt ccgaacttcg tgccgtctgc ttttgtgaca agcggaatcg ttaggccaaa 2500321 cgcttttgct ccttcttctt ctgattttct gatcagttca agacccgctg tgatgttgcc 2500381 ccactgatcg cttccgccga tttgcagttt acagtttttg tctctgtaaa gatttaagaa 2500441 atcataagat tgaagaatca tgtagctgaa ttccgtgtac gagatgccgg attcaattct 2500501 tgagctgacc gtatcttttg ccagcatgta attgatgccg aaatttttac caacgtcacg 2500561 aaggaaatcg atcacattca ttttgccgat ccagtcaaag ttgttcgcga tgacagctgg 2500621 gttttctgct gcttcaaaat ctagaaatct ggacagctgg tttttgattt tttgggacca 2500681 ttcggatacg atgtcagcag tgtttaatgt acgctctgct ttttttccgc ttggatcacc 2500741 gatgaggccc gtcgcgccgc ccacaagcgc aatcggatga tgccctgcaa gctgaaaacg 2500801 gcgaagtgtt aaaataggca gcaggtgtcc gatatgcaag ctgtctgctg tagggtcaaa 2500861 gcctgagtac aagcggattt tttcttcatt cagctgttta tttaaccctt cttcatctgt 2500921 catttgctga atcaatccgc ggaaggataa gtcttcaagt aagttagtca taagataaag 2500981 ctcctttttt aattaaaata aaaaacgccc cttcgtttac acgaagggac gattgattat 2501041 cgcggtacca ccctactaat aagagaatgc aaacattcgt cttatcactt tgcctgataa 2501101 cggatcaggt ccgttctttc actactgaaa gcctggccgg ctttgtttgc aaaagcggtt 2501161 catgagtgta ttcgatatat ccgtctgtgc tgattttcac cggccatcag ctctctggaa 2501221 cgtaaggata ttctacttgt ctcaatcttt accttttcat atgaagctat atcattttta 2501281 acataaataa aatcctgtgt caacgccgcc ttttaatcct ccattgttga cagatctcca 2501341 gccggcagat taagctccca tgccttcagc acgcgcctca tgatctttcc gcttctggtt 2501401 ttcggaagct tatctttaaa ttcgatctca cgcggagccg catgggctgc aagaccctgc 2501461 tttacaaata ggcggatctc ttctttcagt ttatcagacg gctcaaatcc ttccctgagt 2501521 gcaataaagg ctttaatgat ttctccacgc accgggtcag gctttccgat aacgcctgct 2501581 tctgcaatag ccggatgttc gacaagcttg ctttccactt caaatgggcc gacgcgctca 2501641 ccggaggtca tgatgacgtc atcaactctg ccttggaacc aaaagtatcc ctcttcatcc 2501701 atgtaagcag aatccccaga cacataccag ccgcccggca tgaaatacga ttcatacttt 2501761 tcagggttat tccaaatggt atgcatcatg gaaggccagc cctttttgat ggcgagattg 2501821 cccattcggt acggcggtag ctcgttgcct tgattgtcaa cgatcgctgc ctccactcct 2501881 ggaatcggct tacccattga acccggttta atatccatgc aaggatagtt gcagatgagc 2501941 tgactgcccg tttcggtcat ccaccaggta tcatggattc gtttgttaaa aactttatgt 2502001 ccccatctga tgacttccgg atttagcggc tcaccgacac tgagcacatg ccggagtgaa 2502061 gttagatcat atttcgcagc catttcatct cccgctccca tcagcatccg aaaagctgtc 2502121 ggcgcgctgt accagacatt gacgccaagc tgttcaatcg ttccatacca gctttccggg 2502181 ctgaaacgtc cgccgacgat gacatttgtc gctccgttca gccacggtgc aaaaatgccg 2502241 tataccgtac ctgtcaccca gcctggatca gccgtgcacc aataaatgtc ttcttccttt 2502301 aaatcaagga cccactttcc tgtttgatat tgctgaatca tcgcttcatg gacatgcaac 2502361 acgccctttg gcgtaccagt ggaacctgat gtatagtgaa gcagaaagcc gtctttttta 2502421 tccatccatt cgatatccaa tcttgtgctt tcctgtttcg ctgcttcatc ataattgatg 2502481 atattcgtgc cgctctcagc ctctcccccg actacgaaga catgctgcaa gtgaggcagt 2502541 ttgtctaccg gtattctctc cagcagctca ggcgttgtga caacaacctt tgcctcactg 2502601 ttttcaagcc ggtctttcac cgctccctcc ataaatgctt cgaacagcgg cccggcgatg 2502661 gcgccaattt tgattgcgcc aagcataata aaataaagct cgggtgatct cggcataaaa 2502721 ataaaaacgc ggtccccttt ttccacattt ccataccgtc tcagcacatt cccggctctg 2502781 tttgattctt ccttcatttc tttaaatgtg tatttttcat ccctttttgc gtctttataa 2502841 taaagcgcta ctttgttttt tcgaaacgat tcggcatggc ggtcaatcgc ttcatacgcc 2502901 gcattcagtt tccctgtctc atgccaagag aaatgtttct ctgcctcggc ccaatcaaaa 2502961 tgccggtacg tttcttcata gttttttaag ttatgatccc cctctattgc tggtaacgct 2503021 ttcaagttca tgcccaaaca tccccctttg ctgaagttgt cacaattatt atagtatata 2503081 ttcatattct tctcaatttt taaaatataa accatgttga aaacgcttta taatttggta 2503141 ttcttaaaga aggcatgtat ttttgataag aattgatggg acggtgaatt agtggaacat 2503201 cataaaacat accattcagc aaacatcaaa acagcaaccg gctctttact gatagaaggg 2503261 cctgtctctc cagaggattt ggcaggttat gagtttcata aagatttaac cgcatttcgc 2503321 ccgcctcgcg agcagcatga agcgctagtc gacattgcag gccttcccga agggcgcatt 2503381 attattgcca gagacggccg aaccattgtc ggctatgtca cgtatttata tcctgacccg 2503441 ctcgaaagat ggtctgaagg aaatatggag gatttgattg agctcggagc catcgaagta 2503501 gcgccggact atcggggatg cgctgtcgga aagacgctcc tgaccgtcag catgatggat 2503561 gaacaaatgg aaaactacat tgtgatgacg acagaatatt actggcattg ggatttaaaa 2503621 gggatgaaaa aagatgtgtg ggaatacaga aagatcatgg aaaagatgat gaatgcaggc 2503681 ggattggtct ggtttgcaac ggatgagccg gagatcagct cccaccctgc aaactgtctg 2503741 atggcccgca ttggaaaaaa cgtcagccaa gaatcaattg agcaatttga caggctccgt 2503801 ttttatcatc gttatatgta ttaactgaca ctgacaaagg ggaaaaaata atgattgttg 2503861 agcaaatcat gaaaagagat gtcattacat taacgaagac ggatacgctt gaaacagcaa 2503921 tatgcaaact gaaggaattc catatcaggc atctgcctgt tgtagatgaa gaacgacacg 2503981 tgatcggcat gattacagac agggacatga aacaggccag cccgagtatt tttgaagaaa 2504041 acaaacgaag cctatttctc acacgaagcg tagattcaat tatgaaaaag gatgttgtct 2504101 gcgcccaccc gttagatttt gtcgaagaaa tatcagccgt gttctacgag catggcatcg 2504161 gctgcctacc agtggtacac catcaaaaat taataggcat tttaacaaaa accgatttgc 2504221 tgcggacgtt tgtcaaattg acaggcgctg accagccggg ctcgcaaatt gagataaaag 2504281 taaacgacat caccaaaagc ctcgctgaga tcagcagtct ttgccaagac cttcaagtga 2504341 aaatattaag cgtgcttgtt tatccgcatg acgatcccgg tgtaaaagtg cttgtcttcc 2504401 gtgtaaaaac gatgaatccg ctgccgtttt tgcaggcatt acaaagaaat ggacaccacg 2504461 tcgtatggcc gtcagagcaa agggatctgc tatgagagac agtgtattta tctattctcc 2504521 atcctaccaa acctatatgt ttcatcagga gcatcccttt aatcagcagc gggttctgtt 2504581 aacatatgat ttgcttaaga cgatcaatgc ctttgatgat ggagacattg tcacccccag 2504641 actcgcttca gaagaggagc tttcccttgt ccacacggac gattacattc aggccgtaaa 2504701 gcttgcgggc gccggaaagc tccccgctga agaaggagaa agctacgggc tcggcactga 2504761 agacacaccc gtctttgccg gcatgcacga agcggcatca ctcttggtcg gcggcacttt 2504821 aacggccgca gactgggtca tgtcaggaca agccctgcat gcggcaaacc ttggcggagg 2504881 gcttcatcac ggctttcgcg ggagagcatc aggattctgc atatacaacg acagcgctgt 2504941 ggctattcaa tatatccaga aaaaatatag cgccagagtg ctttatattg atacggacgc 2505001 ccaccacggg gacggtgtgc aatttacatt ttacgataat cctgacgtat gcacgctgtc 2505061 cattcatgaa acaggaaggt atttattccc tggaaccggt cagatccaag aaaaaggaag 2505121 cggaaaagga tatggctatt cctttaatat tccgcttgac gcttttacag aggatgattc 2505181 ttttcttgag gcttaccgga cagcagcttc agaagtcgcc gcgtatttcg agcccgatgt 2505241 cattatcagc caaaacggcg ccgatgccca ttactacgac ccgctgacgc atttatcagc 2505301 aacaatcaat atatacgaag aaatcccccg tcttgcacac actttggctc atcaatattg 2505361 cggagggaaa tggattgcag tcggaggcgg cggatatgat atttggcgtg tcgtgccccg 2505421 cgcctgggcc agaatatggc ttgaaatgaa gggaattgac ccgggtcacg agatcccgcc 2505481 ggaatggatt gttaaatggc aaaaacaatg ccccgtggcc cttccgtcga gctggagcga 2505541 tccggctgat ttatatcctc cgattccccg caagcctgaa attacagaaa aaaatgccca 2505601 aactgtcagc aaagcattat atgcgatacg ttctgaacag caaagaacaa agtaaaaaac 2505661 gacctttacg aagaggtcgt ttttgatttt ttaatcacta tttccacacg ccgattttcc 2505721 ttcatgtgtt catttgtctt gttatccttt actggctttg tatccgcata accgacagca 2505781 ataaagcgct tggagggaag cttctcttta gacgtgaagt attgaatcac tccacttgcc 2505841 cgtgctgctg atagctccca gttcgacggg tatcggtatg tcgaaatgtt tcggctgtct 2505901 gtatgtccct caacctgaat gtcatttgga attgtttgaa gaagaacggc aatttggtga 2505961 agaagtgttt cggcattttt cagcaccttt gcctcacctg tatcaaacag cacagcctcc 2506021 tgaagaacga gcacgacacc gcgttcatcc cgtttggctg tcatttgggc cttcaaatga 2506081 ttgtctttta tatatgtatt tactttcttg agaagctgat cctgctgatc ctcttgcttc 2506141 ttcgtatcag atggggatgt attctttttt tctatggatg tttggtccgg ctgaagcccg 2506201 ttgccttcct tctggatcga gtccactgcc gctttgaatt tttgcagatc gatttgggac 2506261 atcgaaaaga gtaaaataaa gaacacaagg atcaaggtga tcagatctgt aaaggttacc 2506321 atccagctgg atgaagattg actgtttttt ccgcttccat tccttctttc aaaacgttct 2506381 cttctaagct tcatgtacag atcccttttt tgtttttact tgttttggct gcttctgcca 2506441 ttcttcccgt gagctgaaaa cgaccagctg gctttcaagg ttgcgcgggt tttttccgga 2506501 ttgaacaccg ataatccctt ccaccattac ctgcttgatg aaaatttcac tttctgtttt 2506561 ctcttcaagc ttagccgcga tcgggttgaa gaccatattt gccagtaatg aaccatataa 2506621 agtcgtcaga agcgcaatgg ccatgtttgg tccgagcata tgcgggtcgt ttaagttttt 2506681 gagcatcagc acaagcccga cgagtgttcc gatcattccc catgccggag cgaattctcc 2506741 cgctttttca aaaactcgcc gcccttttcg gtgccgttcc tccattgctg cgatttctga 2506801 atccatgacg agccgaatcg tttcttcatc ccagccgtca atcgctaaaa gcagcccttt 2506861 tttcaagaat ggatctttga tttcccgagc ctgatcatcc aatgataaaa gcccgtgttt 2506921 tcgcgcgtga tcggaaaggg aaacaaaggt tttcacaaga tctttcacat tgtcttcctg 2506981 gcggatgaat gcctgcttta acacagaggg cgcttttttc agctcacttg gcggaaaact 2507041 gataaaaaca gcggcgcaaa gtccccctgt tacgatgaag aaagaggtca gatcaagaaa 2507101 agagcggaaa ccgcttactc ccgatcctga aataatcccg ataacaataa taatcgttcc 2507161 taacacaaat ccaacaggtg taagataatc aaaacgtttc atcatttctc cccatgaaaa 2507221 aagcaagaat tcaccataaa ggtgaagctt gctctttgtt tttcttatga cttggttgac 2507281 tttctaagct ctatacggtg cggcagttcg acgatatgct cttcaaccgg ctctttattc 2507341 atgagcttcg tcagcagtct catcgcaacg gcgccgatat catatgtcgg ctgaacaact 2507401 gttgaaagct gaggacgaac catgaggctt aatcttgtat tatcaaaacc gataatgtcg 2507461 agatcctccg gaatggataa gccctgatcc tgagcggcat ggataatgcc gagtgccatt 2507521 tcatcagttg cagaaagaat ggctgtcggt tttttatcca ggctcatcag atgctgcagt 2507581 gcttcgagtc cggaatcata tgtgtaatcc ccttcagcta caaattgttc attaaacgga 2507641 aggttcgctt cttcaagcgc acgtttgtag ccttggagtt ttttcgaacg gttgatcggt 2507701 tctgccattg gtccggaaac gaacgcgatg tctgtatgtc ctttatcaac caaaagcttc 2507761 acggcatcat aaatcgcctg ttcgtaatcg atagcgactg acggtgtttc ctcctgctct 2507821 tctacagaag cggcaagtac aatcggcact ggagaacgct taaattccgc cacatgctcg 2507881 tccgtaatgt ttccgcccat aaacacgatg ccgtccactt gtttgccgag cattgtgttt 2507941 aacaagtgca gctctttctc catgttttgg tcagagttgc tcaaaataat attgtattta 2508001 tacattgtcg cgatatcttc aattccgcgc gcaagctctg aatagaaaat gcttgagata 2508061 tcgggaatga tgacacctac agttgttgtt tttttacttg ccagccctct tgccaccgcg 2508121 tttggacggt aaccgagacg ttcaatggct tccaagactt ttttcctcgt tgtcggtttt 2508181 acattcgggt tgccgttcac gacacgggaa acggttgcca tgcttacatt agcttctctc 2508241 gctacatcgt agatcgtaat attgctcatc ctaaaaccac tccttttact ggatacactt 2508301 atccttatct atagcataaa cactttatgt agagaaatgt cataatgtcc gaatttatgt 2508361 cgtttatgat ttgtaagcgt aagtcagtag tgtacattat ttttcattat tcatcaaatt 2508421 taattacttc tcatgaaatt atacacgttt ttatagatga tgaaaacgta tacttggttt 2508481 ttataactaa ataaacgaga aagcataaaa aaaggccgca ggcgcggcct tttggattgt 2508541 tcaattaagc gttgactttc accattggct tcagttcatt cagccatttt tcgaattcag 2508601 gaatcgccat ttgctgagca gagtcagaaa gtgcgactga cggatcaggg tgaacctcag 2508661 ccattacgcc atcagcaccg atcgctaaag cggctttagc tgtcggaagc aagaggtcac 2508721 ggcggcctgt tgaatgcgta acatcaacaa agactggcaa atgcgtttct tgtttcaaaa 2508781 tcggcacagc tgaaatatcc agcgtgtttc tcgttgctgt ttcatatgtt ctgattccgc 2508841 gctcacaaag gataatttgg tcatttcctt gtgacatgat gtattcagca gcattgatga 2508901 attcagagat cgttgcagca agaccgcgct tcagaagcac tggctttttc acggcgccgg 2508961 ccgctttcag caattcgaag ttttgcatgt tgcgcgctcc gatttgaatg acatcaatgt 2509021 agtccagcgc ttcttcgata tgagccggag ttacgatttc actgataacc gccagatcaa 2509081 attcatccgc tacacgtttt aaaatttgaa ggccttcaac accaagccct tggaaatcgt 2509141 atgggctcgt acgaggctta aaggctccac cgcgcaaaat tttaatccct tgttttttcg 2509201 cagctgcagc gacttcagct acctgctcat agctctctac cgcacatggg ccgacaatga 2509261 atctttgctg gccgtctccg attttttcgc ctttgatatc aacaattgta tcttcaggtt 2509321 ttttcttgcg ggagacaagc agcgctttgc tgtgatcttc ttcctgaagc tctaaaccgg 2509381 ctttgaatat ctctttaaaa atgtgctgga tggttgaatt ttcgaacggc ccgtcattgt 2509441 tttcaatgat attgtttaac attgtgcgtt ctctgacagg gtcaaatcgg ttgacaccct 2509501 gtgcttcctt cgctttaccg atctctttta caacattgcc gcgttcgttg attaatttta 2509561 aaatttgtag gtttaattcg tctgctttct gccttaaaag ctctaactct gtgttgctca 2509621 tttttttcat cctttccctg cacattcatt ttttattttg tagttatcat gcatcttact 2509681 ataagtaatt ccaaatggaa atactgaaat acaaaaaatt ttataaaaac tctactttat 2509741 tacccaaacg cttttaagtg ataaagtaat ctatgaagct atcctacatg atgtgagggc 2509801 aatgttcaag ggttttttac aaaaaaaagc gccagatgat atctggacgc ttttttctat 2509861 gacaaatgct gctcaatagc ggcttctgta atttgtgaat gtgaggtatg ccatttcact 2509921 tcaccgttct ggatgatgaa tatctgaggg ctttcatgct tgaccccata tgtttctgca 2509981 atgaaattgg acagcggccg ggcttcttgt acttgaagat agtaagccgg cacatcctca 2510041 tgctgatttg caaaggcatc aaactcatga aatgctgcct ggctgatcgg gcatgtggtg 2510101 ctgtgtttca agaagacgaa aacgccttcc tgttctgcaa tccgtttaaa ttcttcctca 2510161 gattgaataa gctgtttagc catgactcaa gctcttcctt ccctgctcag cgattcaact 2510221 gctcagcctg tttttgtgca tctttcagtt cgtcttttac atcttctttc gtctggagga 2510281 cttgatcttt tgtttcatca gctgcctgca tcgcttcttc cctcatatct tgcattgcag 2510341 tcgatgaatc cgttttgtca gatttggaac ggtctctcaa atcctttacc ttgttcatga 2510401 tctgtccaga ctgatccgct acaagctgtg tgatgttgga agttttgtct tttgcgatgc 2510461 tgacatattg cgtgcctttt tccttcgcat ctgccgtcat tttatcagtt ttgtcccgta 2510521 aggcaacagc ctggctgccg agatcgtcgc gaagttcttt gcctgattta ggcgctagaa 2510581 aaagagctgt agtggcaccg atgattcccc cgattaaagt tccgattaaa aaatctttac 2510641 tattaattcc atctttgctc atcattattc ctcctcttag tatttttttc tcttacaggg 2510701 ctgatttttt cttttgcttc catttctccc aaatttccat tgctgcttga ctccaagtga 2510761 caacttgatt gatcttatct tgattctctc taactgatgc cgatacagac cctgccgctt 2510821 gtttcatgga tgtattgaac tgctgtacag aagctcccac tccttgaaca gcatgaacga 2510881 ccgtgttcag cttttctgat ttttcctgaa tatcttcagc caggcggttg gtcttatgta 2510941 aaagctcggc tgtttcagtt gtgatgccct tcatttgtcc ctccagccct tcaagagtgg 2511001 atgcgacgtt ttttagtgtc agctgcagtg acttcaatgt tttagacaag tagatcacta 2511061 atacgagaaa tgcaactgcg atgagtgcaa cgctcaaata aagaataata atcatctcaa 2511121 acctccttgc tgcaggatat actgctgttt acccgttttc ttcaatcata aacatgtgta 2511181 ctgggctgta tacatactat tctccgttat gtaagaaaat cctttaataa gctttcccat 2511241 cagataaata aaaagcagtg agatcactgc tttttattat gccatgacgt tttcgtaggc 2511301 tctcatatat ttttggatat ctcctgctcc catgaagatg agaacggctt tatcatgagc 2511361 ttttaaaaca gatgtgtcat cttcttcaat cagcttggca ttatgaattt ttccctggag 2511421 atcaccgatc gtcagctttc cggcattctc acgggctgag ccgaaaatat cgcataaata 2511481 cacacagtcg gcgccgctca ggctttctgc aaattcgtca aggaactgct gcgtccgggt 2511541 aaatgtatga ggctggaata ccgcgacaat ttcccgatca ggatacttct gtcttgccgc 2511601 ctcgattgtc acttttattt ctgtcggatg atgggcatag tcatcaatca gcacttgatc 2511661 cccaagctgc ttctcattga atctgcgttt gacgccccca aaggatttga gagcatgctt 2511721 aatgatgctg gaatcaattt cttcataatg gcataacgca atgaccgcca atgagtttaa 2511781 tacattgtgg tggccgtacg caggaatata aaacgtatca tagaacgtat tgcggacaaa 2511841 gacatcaaaa gttgtccctt ccgtgctttt tacgatgttt ctggcttgaa aatcattttc 2511901 ttcccccgtg ccataataca caaccgggac gttcgcatgg attttcggca gatgctcatc 2511961 gtctccgcag gcaataatgc ctttgttgac ttgaagagcc atctcttgga aagcgtcaaa 2512021 tacatcgtca atgcttgaga agtaatcagg gtgatcaaaa tcaatattcg tcataatcgc 2512081 ataatctggc tgatagctta agaaatggcg gcggtattcg cacgcttcaa acacaaagta 2512141 ttcgctgttt tcatttccct ggcctgttcc gtctccgatt aagaaagacg tcggttttgc 2512201 gttttggatc acgtgagcca gcagacccgt agtcgacgtt ttgccgtgtg cgcccgtaac 2512261 ggcaacactc gtgaattttt tcatgtagtc gcctaaaaac ttatgataac gtatcaccgg 2512321 aattccctca gacatcgctt tttctatttc aggatgcgtg tctgggaatg cgtttccggc 2512381 gatgactgtc atgccgggtt taatattttc cgcgctaaaa ggaagaatcg taatatttct 2512441 tttttcaagc gctgtttgcg taaaaataaa tttttcgata tccgatcctt ggacagtata 2512501 tccattatca tgaagtattt gggcaagcgg actcataccg gtccctttta ttccaacaaa 2512561 atgataaaca gtcataattg tacctccaac aaacgtctat ctgttcccca gtatatgacg 2512621 ctcatttcaa tttgcgaccg cggcggctga aaagcctccc ttagcggcgt attttatatg 2512681 ttttgttatg tttagtatca ggttatttct ttccgattaa acccagatat caagatttgt 2512741 ctatgcacag ctgctgtaaa gcggcatagc tgttaaatgc tctaaacact atcataccat 2512801 gtttggtgtg aaaatgaacc catattattc gtttattaaa tcacttgctg tgatcagcac 2512861 ctctcgaggc ttgcttcctt ttgcctcaga gatcatgcct tccgcttcca tcatgtcgat 2512921 cagccttgcc gcacgattgt aaccgattct gaatcttctt tgcaggcttg aagtgctcgc 2512981 actgttttgc tctacaacaa actcacacgc ttcgtaaaac agttcgtcct cttctttcag 2513041 ggcagatcct tgtcttacga gctcttcttg ttcaaataaa taggtcggcg gcatttggct 2513101 tctgacgtgg gaaacgacgc ggtcgatttc ccggtctgac acaaagttac cttgcagacg 2513161 aaccggtttt cccgagccgt tttccaaaaa gagcatatcc ccttttccga gaagcttttc 2513221 tgcaccggct atatcaataa ttgttcggga atcaacctgg cttgagacag aaaaggcgat 2513281 tctcgttggg atattcgcct taatcagacc tgtaatgaca tcgactgacg gacgctgagt 2513341 tgcgacgaga agatggatac cgcacgctct ggctttttgg gcgatccgcg caatgctttc 2513401 ttccacatcg tttggagcca ccatcatcaa atctgcaagc tcatcaataa tgacaactaa 2513461 atacggcagc ttttcaccca tttggtgttc agcggttaat tgattaaagc ggtcaatgtc 2513521 gcggacacct gaatgggcaa aaagctcata gcggcgctcc atttcctcaa cgacccattt 2513581 caaagcagcc gtagccgctt tagcatcagt aatgaccggg ctgacgaggt gaggaatttt 2513641 attgtaaggg gccagctcta ccattttcgg atcaatcagc agcaccttta cctcactcgg 2513701 gtcagcttta taaagcaggc ttactaatat tgtattgatg catacgcttt ttccggagcc 2513761 tgtagcgccg gcaatcaagc catgcggcat tttcttcaag tcgataacaa caggatttcc 2513821 cgaaatatct aatcccagcg cagctgtgag cggtgacttg cttgtcctga aagctgagct 2513881 gcgaatcatt tggcgcaaat caaccacctt gctcgtgcgg ttcggcactt caattccgat 2513941 cgtgtttttc cccggaatcg gcgcttcaat ccgaatatct ttagctgaga gactgagttt 2514001 aatatcatcg gacaagttgg tgattttatt cacctttaca cccggttcag gatgcacttc 2514061 aaatctcgtg acagacggac cctgggttac atggaccaca ttggcgcgga cattgaaatt 2514121 tttcaaggtc aaatcaagaa gctgacgctg ttcttcgatc cacgcagtat catcttgaac 2514181 ctgcgctggc gggacatcaa gcagtgcaac attcggaaat acatagctgc cgcggcgctc 2514241 ctctgctttt tgctgtttat gcgtatctct tttcagcatc atcacattaa aaggaacgga 2514301 tggccctttt tgagaagatg cgctttgttc agtccttttc tcctgtacac caggcctttt 2514361 tttcggctct tctgaagctt cgcgaggttt gtctgcgcga atttcctgcc ggttttcaag 2514421 agttgcagta gacgatttgg aaccctgctc catgtgttca gttttctcaa gctctgtatg 2514481 gctgtctggc tgaacatcta tcttcgtttc ctgagcctct cccagggtgt cataatgatt 2514541 atttattatg ctttctgatg gctcttctga ttcttttgcc acagtttctg cttgagccag 2514601 agcctctgat gaatactcat gatcagtaaa taaaggctct tcctgacgaa tgtccatttg 2514661 ttcttcttga acgaacgggg actcagcacc ttctgccgcg ttttcatgat gattgtatac 2514721 tgggctgtct gacggctctt ttgctttttc atcctcagat actgcctctg tctgagattc 2514781 aggagctgtt tgctcttcat caagttcagc ggagaaaaca ggctcttcaa atttctctgg 2514841 ctgctgctcc ctttgttctt cctcagccgt tgcaggctct tcgcggccta cttcactgtc 2514901 tgaaagccct tcagccgccg tatctgtgag catctcaggc ggtgtttgct cttcggcttg 2514961 ttcagctggg aagaaaggct cctctttttc cggctgttga acgcctgact caaatggcac 2515021 tttgttacct gacggctcgg ctggccgttt cgccagcgcc tcatcatgct ccgtatcctt 2515081 tctgtttaaa acgccagaag gctgtttttc aaattgggta tccgggaaga aaggactttc 2515141 tattttggaa tgcgcctgtg tgtctgaagc aggatagccg cgttcacgtt cgatctcttc 2515201 tgacagcagt gttaccttct cttttaccga tttatccggt tcgttcaatg tttcagaagg 2515261 ctttttcggc acatcctttt taacagatgg tttttgattg aatccataga caggcgaagg 2515321 gatatttgtc ggtttaaacg gtttcttcgc cggctctgct gcttgatatg tatgctgctc 2515381 ttcttcattt ctgggacgct ctctgtaagg tgcagcactt ggacgaggcg cggatttcgg 2515441 ttcgtccgat ggtgtgcggc gccttctcag gtcatgattt ttgtatccgt caggcacgac 2515501 tggaaaacgg aatttgcctt ttggatattc ataatatatt ttaggatctt ccaatctttt 2515561 taattgtcct tcaggatgat gtacttcttg ttgctgcgga atttgagcgg gttttgtctc 2515621 ccgttcagca tcctcttcgc tttcgcctaa aaacaaatca aaaaatttat gaagccaact 2515681 cataatttat ctctaactcc cttatagttt tctgggacgg tttttagtat accactgctg 2515741 gtcggcccag aaaagattaa gctatcagca gaaacaaagc cgctaaacaa gggcttagcg 2515801 gcttttcaca tgattcgttt tttttggcgg atttatggga gtctaaaact gaaatgcgtc 2515861 tcccgcctca tagtctcctt ctaacacaag gattcctttt tcagcagggg catccggcaa 2515921 atcaagctct ttcgctgagc agatcatccc gcttgacgga acgccacgaa gctctgcatc 2515981 cttaatgaca agtccgctag gcatcacagc accgactttg gcaacgacaa ctttttggcc 2516041 ttggtcaacg ttaggcgcgc cgcagacgat ctgaagcgtt tcttctccta cgttgacttt 2516101 acatacgctt aatttatccg cattcggatg tttttctttt gattctacat aacccacaac 2516161 aaacttcgga gataaatcaa cgactaatgt ttcttcaacg ccgtttctgt ttaaaatctc 2516221 attcacatct tgcacgaatg tttctgagag cgcaacaggg ccgttttcat caatggtcaa 2516281 gtaagaagac gcattgaaaa tgttgaagcc cgttgtttct tttgtttcgt tattgaaaat 2516341 tttgacgacg tcgccgtgtt tttcatagcc taattgttcg cgtgtcacat cttgaagaga 2516401 gatcaggagc gtgtctccca caccttcttt attataaaaa gcgttcataa gtaaaaatcc 2516461 tttctaatcc tttttcggac ggcttttcgc caggataaac accggttcca gctttccttc 2516521 attgtacaaa aatgataggg cggtaatcgg gacggtgccg cctgcaaaga agctcatcga 2516581 catttgtcct agaatatcat accccgattc attccggatg tcagcaagaa tcaaaacgtc 2516641 ctgatgagga acagagatcg ccagctcacc ttctgcatgc tgcttatact catttaagat 2516701 cgcttcgttc aaaatccggc ttgcgtcgta tccgtcgttt gccctgaaga aataaaagta 2516761 attgccggca accgtatcct ctttgacaac cgtcggcagg gaacggagat taaatgcggc 2516821 cgtctctctg atccgctctt ttgtccagtt ttctttctca agcatgcgct ggtcaattaa 2516881 acggtaggtt ttcccgagat ctagcgcgta ataaattctt gtctctgcgg tatgatcgtc 2516941 ataaatgagc gggatatctt cgctggactt gtccgggaag gaagtcgagc ggatgaccgg 2517001 ataaatgcga gtttctttcc cggtcatttc ctgagccttc ccttccattg ccgtcatcgc 2517061 ttcggagaca tagtacacga tctcatcaat ggcttcgtct tttttcagtt cccattttgc 2517121 aataatcggc ggcaaatcga gtgtaatccc ttttttagtc gtttgatcct caacacggag 2517181 ggtgtctttt tctctgtcaa acagaaagga gcgattctcg tgctgaaggc gctgcttcag 2517241 tatatctgac agcttccttg aggtcatttt caaaccgatg tcctccttta cgctttagcg 2517301 agagagtctg ttaaaaactg ttcaatttct tcttttgttt tgcggtcttt gctcacaaaa 2517361 cgatttactt cttttccttc attaaacacc acaaagcttg ggattccgta aatttcccac 2517421 tctgcacatg tatcaatgaa tttgtcacgg tctacgtagt agtaggtgaa ttcagggaaa 2517481 ttcgcttcca gttcaggcag gaaaggctct acaaaacggc aatccgggca ccaatcggcc 2517541 gaaaacataa atacagacca atcatccttt accgcttttt ccagctcttg agttgattca 2517601 atttttttca tttcatatcc ctccagttgt ttatgttctt acatgttttt tatcgatact 2517661 cgtccatttg gatcatacca aactgcttga ggcaaaacca cttatatgca acgaatgaat 2517721 atgtaagatt ggctttccca ttatcattat catattttat ttgcattatc aagctcgttt 2517781 cgtttaacat cgtgtacatg agggtgaaat ttacagatgg atatacataa ggagggattt 2517841 ttattatgga gtttatcgtc tatttagcag gagaaatcca cagcaattgg cgcgaggaaa 2517901 ttaaagaaaa aacaaaatca ctgaagctcc cgattacgtt tgttggcccg atggagaatc 2517961 atgaccgctc agacaatatt ggtgaagaaa ttatgggcgt acagccaaat gccgttttaa 2518021 aggatgacaa agcctctgac atcaacaact tcagaaccgc cgtcctgatg aataaagcag 2518081 actttgtgat cgccctgttt ggcgaaaagt acaaacagtg gaacacggca atggatgcat 2518141 catatgcgat cgcaaaagga aaacccctga ttatcatccg gccggaatcg ctccaccatc 2518201 ctttaaaaga gctttccaat aaagcgaata ttacggttga aaccgttaac caagccatta 2518261 aggccctttc ctatctattt gaaacagaat aagaaaaaag cttgtcgatc cgggcttact 2518321 gctcgttcaa caagctttta tgaaacctac atattttctt taatcgcatc cactgtctgc 2518381 ttatcgcagg ctgttacaag tttgatgagc atttctttag cagcagcata atcatcaata 2518441 tgaatgatag tagcgtttgt atgaatatag cgggaacata ttccgataac cgctgacggc 2518501 acaccgctgt tcgaaatatg aaccttgcct gcgtctgttc ccccgccgga tacaaaatat 2518561 tgatatggaa tatcatgcgt ttcagccata tcaagaacga attccctcat tccgcgatgc 2518621 atgactgtcg ttctgtcaag aatgcgcagc aaaaagcctt ttccaagctg gccgaattca 2518681 tttttgtctc cgctcatatc gtttgccggg ctggcgtcaa gggcgaaaaa caagtccggt 2518741 ttaatcatat gagaagccgt ctgcgcgccc cttagcccta cttcttcctg aaccgttgca 2518801 cccgcataga gtgtattcgg aagctcttta ccgtgtaatt ccttcagaag ttcaatgctt 2518861 aagccgcatc catatctgtt atcccatgct tttgataaaa ttttcttttc attcgccatc 2518921 gtcgtaaacg gacaaacagg cacgatctgc tgtcccggtc taatgccgat tttgatggcg 2518981 tcttccttat catccgctcc aatgtcgatc atcatgtttt tgatatccat cggtcggttt 2519041 cgctgcgcat ctgtcaataa atgcggcggt atgcttgaaa tcacacccgg aaccggcccg 2519101 ttatctgttt gaatttcaac ccgctgcgca agcaaaactt ggctccacca gcctccgagc 2519161 gtctggaatc tgagcagccc gttgtctgta atggatgtca ccatgaagcc gacttcgtcc 2519221 atgtgcccgg ctaccataat tctcggtgcg tcctctgcgc ctcgtctgac tccgaaaaca 2519281 cttcccagtc tgtcctgaac gatgtcatct gcatatttgg ctagctcctg cttcataaaa 2519341 gcacgaacct gatgctcatt gcccggcgcg ccgggaagct gcgtcagtgt ttggaaaagc 2519401 gctttcgttt cttgattcat gttttcccct catttctatg tagtcctttt attttattag 2519461 aaacaatgaa gttttccaag cactctgacc caatctgctc gatcagccgc gtattgctta 2519521 acaggatttg gctgtttctg tataatgaaa agtacgatca accaggaggt gctttatttt 2519581 gaaattgcgt catcttcttt taggagcagg acttggaatt tgtacggctg tcgttgtgag 2519641 acaatatgtg atgaagcctt atatttcttc agaaaaagcg cttcgaattg taaaatctgc 2519701 ttttaagcag cggggcccga ttgacggatc atggatttac acccagccgg agccctacaa 2519761 tattaacgga gaaacggtac aggtatacaa aaccggcatt acacgatcag ctttcggaga 2519821 attagaacag tatgaagtca tggtggatgc gaaaacggga gaaattgttg atgtcattga 2519881 tacaatcgcc tcttaacacc ggacaagcaa aaaatagaag ccgctgccta tgcagcggct 2519941 cttttttatt atatcgcgcg aatcggtttg tataccggat accacatcgc atcctgcact 2520001 gcctgtataa tgtcttcagg ctcttccgta gcgacgcctt ccttcattgc ggtttttgca 2520061 acttcaacag caacggttgc cgaaacagtg cgcaaatctt caacttttgg aagcatcggc 2520121 gccccaggca ccccgacatt gaccatacct gcgattgccc gggcacatgc ttcaaacatg 2520181 ccgtcggtaa ttaattttga ttttgtaaca atcgttccaa gaccgagacc agggaagaca 2520241 agcgcgttgt ttgcctgccc gatatgatac gtaactccgt tatattcaac tggcgggaac 2520301 gggcttcctg tcgtgatcag cgcacggcct tctgtccatt cgattaaatc ctccggcttt 2520361 gcttcagaaa gagttgtcgg atttgacatt ggcaaaatcg ccggccgttt cacatgtgac 2520421 gccatttctt ttacaatttc ttcagtgaaa gcgccggaaa ccgtagatgt gccgatcagg 2520481 atcgtcggtt tcgcctgccg aaccacttca agaagatcaa tgcctccgcc gtctccgttc 2520541 cgctgataat ccttcacttc atcagccgaa cgggcatacg gcttttggaa atcaagaagc 2520601 tgatccatat catctgttaa cagcccgttc ctgtctatgc accagaagcg cttgtatgat 2520661 tcttcttcac tcagtccctc gcgcaccaat gcttcccgca gctgttcggc aattccgatt 2520721 cctgccgttc ccgctccgaa tataacaact ctgtgatctc tcagcggaac tttagacgct 2520781 tttgcacagg ataagactgc ggccaaagaa acagcgccag ttccttggat atcatcattg 2520841 aaggtacaca ctttatcttt atagcgtttc aaaatgcttc gcgcgttttt cgccccgaaa 2520901 tcctcccaat gcagcaatgc attcggaaat gtttctctcg ccagcgcaac gtagtcgtca 2520961 ataaattggt cataacgttc cccgcgcact ctggaatgct ggttgccgac ataaagcggg 2521021 tcgttcaaga ggctctcctg atttgtcccc gcatctaaaa caacagccag cactctgctc 2521081 ggatcaatgc ccgcagccgc tgtataaacc gccagcttgc caatagaaat tgcgattcct 2521141 ccgacgcccc agtcaccgat tcctaaaatt ccttccgcat cagttgcaac aattaaatcg 2521201 atcgtatcgc tttgatcttt atactgttta aaagcttctt tcataccgtc cgggtcatcg 2521261 attgacagat agagccctcg tggttttctg tattcatggc tgtatctctg aattgccgtt 2521321 ccgactgtcg gtgtgtagac aatcgggagc atttccccta aatggtcatt taacaggcgg 2521381 taaaacagcg tttcattccg atcgtgcagc gccgttaaat agacattttt gctcaaatcg 2521441 tcaggctgtg cggaatattg ttcatacgct cttttcgcct gatcatcaat tgttaatacc 2521501 ttgggcggca gaaagccttt taaaccaagt tcttttcttt cttcctcagt aaaagcaaca 2521561 cctttgttca aaaaaggaac agagagcact tcaaggcctc ttaatgttgt ttgaatgtct 2521621 ccttcgtttg ttactctgaa ttgtttcacc ctgcctcttc ctttctgagc ataatagtac 2521681 taggtttgca ttattagccg gaaaacatgc agggtaaaca taaaaatatg ctatcgcttc 2521741 attcgcttaa ctgacttttt gatgcttccg tcctcctccc attgaagggc gcgatactcg 2521801 gcatcatggt aaaaaataaa ccaagcatct ttttctgctg cgaacgcctg ccatttctgc 2521861 ttttgcggga tagaggtcat cggataatca tcgtaagcca gcacccatag cggattgcgg 2521921 tgggcatgtg tcggcatcag atctgccata tgtacggcag tttcacccgc atcctcgcat 2521981 atcaggacac tgtgtccgtc gctatggcct ccggtgtgat gcattgtaat accctctgtg 2522041 atcgttaagg tgtcttcaaa ggttttgact tggccagcta cagcctccca attttctttc 2522101 caatacgtat ttttcgacct gatattcgga tggcgcattt cgtcccattc aacagctgat 2522161 gtataaatca ctgcattcgg aaagacagag acgagccgtt caccttcata ttccgttaaa 2522221 ccgcatgcat gatcaaaatg aaggtgtgtc attgcgatca catctatatc ggcaaccgtt 2522281 aatccgagtg cagctaatga gggtttcaca ttcgactctt gtgtcacgcc atagtttcgt 2522341 ttttgtttat cagtcagctt gccgtaccca attccggcgt caatgatgat attgagccca 2522401 tccttttgaa tcaaaatagg gtctgttctt agttcaatct ggtttttttc attgactgga 2522461 tattttttag accaaagcgg ctttggcaca acgccgaaca tggcgcctcc gtccatatgc 2522521 gtcacgcctc cgtcaagcca ggtcaacgtg atgtttccaa ttttcattgt ttccattttc 2522581 acccccccct atcatcatgg tagcaaacgg cccataaaaa aaacagactc ctgtcagagt 2522641 ctgtctttac gttctccatt caacctcagc ccgatagatc ggctggccga gtgcagagaa 2522701 tttttcttca tattctgtca taatattgcc ttccagattg ctgttatgca aatcgagact 2522761 gacgtatgtc agcaggaggc cgtactcaga gaagctcttc aaagagtact caaataaacc 2522821 tcggttgtcc gttttaaaat gaatcgatcc gcctttgccc attacttctt catatttttt 2522881 gaggaagtgg gaatatgtca ggcggcgttt ttcatgccgt ttcttcggcc aaggatcaga 2522941 aaagttcaag tagacccgtt tcacttcccc cggctcaaac acatccgtca gcgtgtccgc 2523001 atctatattc agaagcttta cattctgcgc ttcgctgtct tttacttttt ggacggctgt 2523061 cacgatgacg cttttaaata actcaatacc aatataattg atgtcgggat tttgtttggc 2523121 cataccagaa ataaattggc cttttcctgt accaacctcg atatggatcg gattgtcgtt 2523181 gccaaacact gtgttccatt tccctttata atcagcagga ttgctgatgg caatatctgc 2523241 gttttcagcc aaaaagtcat cagcccaagg cttgtggcgc attctcatat gattgacacc 2523301 tctatctatt atttcgacta acaacatacc atgaattaaa aagacccgca agctcgtttt 2523361 tccagtgtat ctctcttaag gccgagcgca taaaaaaaga gggtcccgtc tgctggaaca 2523421 ctcctttccc atgtataaaa acgctctgtt ttgaacaatt taacccgtat gatactgaag 2523481 ggatgtgtac cgttatgggt ttacattatg agcatcaagt tcatttattg aaggatatat 2523541 tgactgacca tcaattggac tgctgcggaa cagtcgcaga gtacgagcag cttgagcgtg 2523601 tgattaaatc actgatggca aacaccgagc ttgattcaaa tttcaaaaac gtgcttgaag 2523661 atgtttaccg ctacagccaa tcaggaatat cgtccaaatc catcgactca cacatacaag 2523721 agcatcagaa cagcctgtct caatgggtag agcaaatgga ttcgtattcc tgattaatca 2523781 acaattcgtt tcatgaggat atgcagctct tccattgcat catgaaattc cttatcattg 2523841 ccttttgctt tatgccaggc aatgaaagta attgtttcag ataacacata ccaagccatt 2523901 cgcaaccgaa ggctttctgt cagctctatg ccgtacatgc tcagccagct ctcccaagct 2523961 ggcttttcga cgtagtggta cagcaaaggc ccgaggtcca tcgccggatc agcgatcatg 2524021 gcgccgtccc agtcaattaa atacagctgg ttgtcttcag acaatagcca gttattatga 2524081 ttgacatcac aatggcaaac gactttctca ccgaaatgca cttcatgcag gtgttcttcc 2524141 aaatacttga tcccttcttg aatcagcggc gaagattgct gcacagcaaa tacagcctgc 2524201 ttcagctgag acaaaagagc ccccgggttc agcggttctt ttccaagtct cttcagcatg 2524261 tccagcaagg cttttgatgt gtgtatttta cgaagcaatt cagcaacggg ccgtccgctc 2524321 atgtctttag gcttcagctc tctgccggtc atccagtgct gggccgtaat gacgtcccca 2524381 ttttccatcc gttttgtcca aaccagcttc ggaacaatgc cttcggcgga taaaacagct 2524441 aaaaaaggtg agctattacg ttttaaaaaa agctgctgcc cgttatgttt cgcataatat 2524501 gcatctcctg tagctcctcc ggcggggaag atctcccaat cgctacctag taattgtccc 2524561 aaccagttca tatcaatgtt caacccatca tttcttaaaa tattttagaa ttaaggctaa 2524621 tcgtttctag tctatccagc gaatgccttt ttcgtacgaa tcgtataaaa ataaaaaaga 2524681 cagctattga gagtctcata tgctaatcaa tagccgtcct ttaaatttta gcgctatagc 2524741 acaaacttcg tcaagcaaaa ctcttaagat ctgatgctaa atataagata accgttccga 2524801 tgccgtttac tgcaaccgtt ttcttgattt ctgttgggtc ttcctgaaat cctgatggat 2524861 cacataaaag ccgataaggt atgtcgtttg gcagcctcca ctcgacggag tctggactcg 2524921 cgtgatggat aacaatgata tctttccatt cgtcaacctc gtcaagatca taaagcctgt 2524981 atgcgataag gtgttctttt agcgtcaagc attcaagatg gcgctggatg tctgcagcgg 2525041 acctaagacg gaatgcagga tgcgcttttc tcagcgagat cagcctgcgg atatagtgaa 2525101 catcttcttt gaatgtttca cggcgatccc agtcgagctg gttgatgctg tcactggatt 2525161 gatagctgtt ttccactccc tgcttcgtcc ggaaaaattc ctggccgctg tgaataaacg 2525221 gcaccccttg ggcaagcaaa ataatcgcgg ctgcaagcct ttgcctgctt cgctttcggc 2525281 tgtcattttc ttgaggaagc gcaaagctca ttttatccca aaaggtgtga ttgtcgtgtg 2525341 attcgacata attgatggac tggcttggtt ccggaacaat cggtgctaat gccttccatc 2525401 cggaagaccc ggcaattcca tgcatcacag cttgtgctga ttcaccgttg ccgagcgcaa 2525461 accctgttgc cttaaggtga aaggtgttcc cttttacagc gtcacgaaac atatcattaa 2525521 aaaagccgat gcccggcatt cttggcgcgt tcgccaaagc agctttctgt tcatgcggca 2525581 gcggtgtagc caggtcccac ccttctccaa aaagcaggat tccgggcttt gccttagttg 2525641 ctttctcttt catataaagc acggtgtcaa tatctaaaat cccgaggaga tcaaagcgga 2525701 agccgtcaac attgtattct tcaagccaat agaccacgca atccgcaatg aattttcttg 2525761 ccatccttct ttctgatgca atatcattgc caacgccggt gccgtttgat ggcatcccac 2525821 attcgtcgtg ccggaaaaaa taaccgggca ctgtcttttc aaagggggaa ttctccctct 2525881 tatacacatg gttaaaaaca acatccagaa tgactcgcag accgtgctga tgcagggtat 2525941 tgatcatttg tttcagctct gtttttctcg tttgaggatc atgaggattt gaggcatagc 2526001 ttccctccgg ggcaaagaaa tgaagcgggt tatatcccca attgtatgca tcaagcggct 2526061 tctcttcatc aactccggca aaatcattca ccggcagaag ctccacatgt gtcacaccaa 2526121 gctcttttac atacgctaat cccgaagaac tgccatttgc ggtttgtgta tcagtttccg 2526181 tcagcgctaa gtattttccc ttgtttatca tgccgctgtt ttcatggatg gagaagtcgc 2526241 gaagatgcgt ctcatagatg acggcatcca cagggtgtga gaatggttta agaggagcag 2526301 tccatttcat ttgatccggg cgcaagacga cgcccttctc tccatttaca gtcacagcct 2526361 tggcatactg gtcaactgtt tccatccatt ctgaattgtt gcagatgcaa aacaaatact 2526421 catatccgtg aaggtcacct gtgaccgtga cggcatagac gcctttttcc aagcgagtca 2526481 tttggaatgt gcgcccgctt ttattggggt gtgaaagctt gacagcagct gaggttgcag 2526541 caggcgccca tactttaaat acggtatgat ccgcggtata aacggcgccc agctctccgt 2526601 cataataaaa ttcgtcatca aacgctgccg tccggatgac cgcgccaatt tggagatccg 2526661 ttttgtggcc gctggatgct ctgacgcaat ggatttttcc aaatgtcaca ggatggtcgg 2526721 atacgcagac gtacttgtat tttgcttcaa gggagtattc ctccctgaca gccagaggaa 2526781 aatctgttat ttctgtctca agccgaaacg gcggtgtcat gatttccttt tgttcagcag 2526841 gaatcagaac agtaatgata ttcatgtcat cgacatacgc ttcgaagctg cggcggatgc 2526901 tgaccatcgg aagctctctc ctccaaacac gtttatgttt tgattcttag gggtgaagga 2526961 ctagatgcca gacgaaacgg ggtagtgccc atgatttctc cgtcagcatg gaacgggatt 2527021 ttgtccttcg tgtaaaatgt aatgtccttc gctttaaaca tcgtaacgcc atccatcttt 2527081 gtatgttttc caaatgccat gagacataaa agccaatatt ttttcaaaaa cggctggttt 2527141 tcaacgatta cgatatcaaa tgtcttctcg cgcggatttg ctaggggcgc cgccttcatg 2527201 cctcccccgt aaaacggatg gttggataca acggcaaacc agacatcatg aaattcgcgc 2527261 gtctcgtctt ccgtcgtaca agctaatgta aacggcttaa aggttgccga agcgtgcaaa 2527321 tgagaaagcg gatacacaag aaatcgaagg cggagaaaaa gaaaaacccg tctcaacgga 2527381 aattccatcg cctttttatt gacatatgcg tcaaacccga tcccgatatg attcataaaa 2527441 taaagaatct gtgatttatc ctgaaggaaa ttgacgctcc ctaaatgaaa ggttcttgtt 2527501 aacgggcgct ttaccttctt gatttcctgt atcagatcga tttttttaat agagaaccct 2527561 cgcgaaaaat cattatacgc gcccgccggc acaaagctca gctcaatatc gtcaacatct 2527621 ttcagcccgt tgacaacttc atgcatggtt ccgtctccgc caatgacgat caggcgcttc 2527681 agcttatatt cctgtatcgt tgaaatctgt ctggcgagca cctcggcgtg tcccggatgt 2527741 tcagttaaaa atgaacggtg ctcaaccttt cgtttgatca attctttttg aatggacttc 2527801 caaacacgca ggccgtttcg atgtcctgct gtcggattaa taataaaaaa ccaatggctc 2527861 atctttctca cctgcttatg ttatgagaaa accgctcaaa tcgttctctt ttactccagc 2527921 cactcctgtc tgcgatagga gtcagacatg cagtaagaca atagagcctt tgcagccttt 2527981 acctgatgat gtttgatcgg agcagtgttt ttcttctgcc gctcaatcca ttcttccgcg 2528041 ctccgcttat ccgctatttc taagccgtat ggcggctccg ggtaatcgat gtacgacgtt 2528101 ctgctcagaa gcaattttcg aaccggaatc tcagcctgtt tttcctttac gatctttgac 2528161 acaaccgagt ccgtacgaaa caggctaagc cctggattta acactgatgc agtctgagag 2528221 gctgttttct tgtcccaaaa acgattttta gaccctatgt agacactgtc ttcctcagcc 2528281 tctaaaaaag aaacgcaata aatttccaga ggagaaataa tcacaatgct taattcaacc 2528341 gccgcctgct gaattttcag cacaggctta tacataataa aataagaatc aggcagctgc 2528401 tgggtcagat aacgcaaaat gcggtcctgc ttcacttggt ttgagagttg agatatttct 2528461 gaaagagtag agcttgccca tttgagctga aaatcatata aatgcctttt ataaaaagaa 2528521 gcaagcgcca ccctgctctt cgggagcctt acatgaatat cttcttcgtc ctcaaaccat 2528581 tggtgtctct cttcttgtat atcggctttt atctcttctt ttcttctttt caatgaaaat 2528641 ttttttcgtt tctgcaccgg ttccggttct tcagcactgg cttgcctttc ttcatgctgg 2528701 cgctccgctg cttctactag tgaaagccag cgctcttttt tcaaacgtac aaactggttg 2528761 atataatggt acggatcaag ctcatatctc gatatataat catgaatttt gatgatttgt 2528821 gccatgtttg tttctccact ccgcaatgaa ttaagataat tgaaatttga atatttcctc 2528881 gtattttggt gattggttca agtgtatttg aaagagcgaa aatcgttcag ccatcatcga 2528941 aacctcgccg ctttcaaacg gaacatgagc tggaaatcca tcttcgcctg tccattttct 2529001 tgccagcgtc atatgaggat gatacggtct tttttccact tgaaagccgg cctgaagtac 2529061 agcctgcttc gtatgttccc gcagtctatc aagcgttttg tttttctttg gctccagatg 2529121 taaaacgcgc ggctttctgc ggtcgccgaa tacatctatc ttgccaaact taattgaaaa 2529181 tggatcaatt tctgaagcaa tctctgctag cgaaccttca agcttcttta tttgtgtctc 2529241 atccgccgct ccgagaaaaa ttaacgtgat atgatagtca agcgggtgca cccatttttg 2529301 aaacgtcaat atcggttcgt ttttcgcagc ctggtagatc ggatttgcaa ttccctcagg 2529361 tatgggaacg ccgatgaaat aatgaggccg tatatctggc atccgtctga cactcccttc 2529421 tttgacagct attattttat caataaagag gctgtgcgga tagaggaaca gtgtatgaaa 2529481 acactctcgc acaaacgttt attatgttag gatattatat gacacttgtt ttattcagaa 2529541 aggaatgaca atgttgaaaa tcgttgcaaa cacagctgat ctgataggag atacaccgct 2529601 agtgagattg aatcggcttc agccggaaaa tgcggcacaa gtctatttaa agcttgaatt 2529661 tttcaatccg agcggcagtg tgaaagacag agccgcttat caaatgatca tagaagctga 2529721 acaaaacggt ttactcaagc cgggatcagt tattatagag ccgacaagcg gaaataccgg 2529781 catcgggctc gccatgaatg cggcagcacg cggatataaa gcaatcttag ttatgcctga 2529841 tacgatgacg aaggaacgga tcaacctact taaagcttac ggtgcagagg ttgtattaac 2529901 tcccggagag gaaagaatgc cgggcagcat caaaaaagcg aaggagcttg ccgaacaaat 2529961 tccgaacagc tatattccaa tgcagttcga taacactgct aatcctgatg cgcaccgaaa 2530021 aacaacagcg cctgaaatcg cccgggcaat agaggaaatc ggaaaaccgc tcggcgcttt 2530081 tgtagcctcc tctggaacgg gcggaaccat taccggaaca ggtgaggcgc tcaaagagct 2530141 ttttccggat atcacggttc atgttgttga gccagcgggt tcgcctgtat tatccggcgg 2530201 aaaacctggc gcgcataaac ttgtaggaac gagcccaggc tttataccgc cgattttaaa 2530261 tgaagacgtt tatgatgaaa ttatcaaaat ctctgatgaa gacgcgtata cgacgacaag 2530321 acggcttgct gctgaagaag gaattcttgt cggtccttca tcaggcgctg cctgcttcgc 2530381 ggcaatcgaa acagcgaaac gcctctctcc tgacaaagtt gtggtctgca tgacagctga 2530441 tacaggagaa cggtacttat caactgattt atggtcattt atttaaaaaa aggactggct 2530501 tcagcagaag ccggtccttt tattttgcaa gctcgtaaat ggcctgagca tataacgctg 2530561 tcgatctcag caggtcatca atttcgatat attcatcctt ttggtgtgcg ctgtcagggc 2530621 gtccggggaa cagcgggccg aacgcgacac cggcttttaa ggatctcgca taagtccccc 2530681 cgccgattga gattaaatca gcttttttac ccagctggcc ttcataaacc ttttgcaggg 2530741 ttttgactaa cggatgatct gcggacacgt gatgcggctt gctgtctttg aattctccca 2530801 gctcaaattc agatgcgctt tcgaatgtat cgcggatcac tttgctttct gctgtcacag 2530861 gatagcggat attgatcccg agctcgcctc cttgcccttc tttatagcgc agtgttccga 2530921 catttaatgt cagctctccg ctgatttcat cctcacagtc gatgtccagt ttttttcctc 2530981 ttgtatcacc tgagaactta tctgtcacaa cttgcacaaa ccgctttcct gcatcgtcaa 2531041 gctcagtctg ctggagaaat tcgcacaata aaatgccggc attgatccca ttgttcggtt 2531101 ccatcgcatg gcaggaaaga ccgtacatac gcaaaatgag ctgtccgttc tctattgcag 2531161 cttccccttt ttggtccgtc gtgcggagca tgtctttaaa tgaagacaga atctcttcat 2531221 ttttcggccc ttcaatgaca gcttccgcag cgtcgggcac catgtttaag cgaaggcctg 2531281 attgaaacga gacaagcact gcctttggtt cagcttgatt tgggcggtgc ggaataagta 2531341 aagaagcatc gatgatccct ttttccgcat taatgatcgg aaaatcggcg tcaggcgcaa 2531401 agcccattgt tggcatttct tcatgcttga aataatgctc tacgcatctc caatcacttt 2531461 cttcatctgt tccgataatc attctgactc gcttggacag gggcaaattc atgtctttca 2531521 cgattttcag cgcgtagaat gccgccattg tcgggccttt gtcatcaatg gcgccccttg 2531581 cataaatccg tccgttgcgg atttcagctg aaaatggatc actcgtccac ccatctcccg 2531641 gcggcacgac gtcaacatgg caaagtacgc cgataatgtc atcgccctcc ccccattcaa 2531701 tatgacctgc gaagccgtca agattttttg ttgtaaagcc ttctttttct ccaagctcca 2531761 gcaatgaagt caggctggca tttacccctt ctccaaacgg tttaccgggt ccggcggttg 2531821 tttcgtccat gacactgttg attctcaaaa attcctgtgt atcacgaatt aaatcctctt 2531881 tttttctgat cacttcaact tcccagttca taatgatccc ctttccgcaa gaaatgactt 2531941 gcaaaaacca aataaaacga ataatattaa tggtgttttg ttaaaacgtt cgtaattgga 2532001 ggatactatg tttcatctaa aagagcagca aacatccata aagcaagaaa tcatagcagg 2532061 gctgacgacc tttttcacaa tggtctatat cgtcgtggtc aatccggtca ttctggctaa 2532121 cgccggggtt cctttcgacc aggttttcac cgcaacgatt attgcctcca ttgtcggaac 2532181 gctgtggatg gccctggcag caaattatcc gattgctatt gcgcccggca tgggcttgaa 2532241 cgcttattta gcctttcatg tcgtaagcgc aagcgatggc ggcatcacgt acgcaacagc 2532301 tttcagcgca gtatttacag caggggttct cttcattatt ctatcgttaa cgcctttaag 2532361 aaaacaactt atagaagcga ttccaaacaa tttaaaatac gggatcacaa cagggatcgg 2532421 gctgtttatt gcttttatcg gtttgcgtca agcgggaatt gtggcagctg atgagtcaaa 2532481 cctggtcact ctcggcaatc tgcattcacc tggtgttatc ttaacgctgg tcggcctttt 2532541 gatcagcgtg gtcctgatgg tgctgaatgt aagcggcgct ttatttatcg gaatggcagc 2532601 taccgctttg atcgcctttt tcaccggtca gctccatttt tcaaagggat ttatgtcgct 2532661 tcctcatttg ccggaaggat tgatgatctc aaatccattt accgcttttg gcgatgtcat 2532721 tcatcacggc ctgtacgctg tcgtcttttc ttttctatta gtcaccattt ttgatacgac 2532781 aggcacgatg atcggagttg ccgagcaagc cgggctgatg aaaaacaaca agctgccgaa 2532841 cgtgcgaaaa gcgctgcttg ctgattcaac cgcgacgaca gtaggagctg ttttcggcac 2532901 aagtccgacg actgcattta tcgagtcttc cgccggtgtc gcagccgggg gaagaacggg 2532961 gcttacggct ttgactgtcg cggtgatgtt tgcggcttca atgtttttca gtccgcttgt 2533021 cagcgccttg tcaggtatag ccgccatcac ctcgcctgct ttgattatcg tcggcagcct 2533081 gatgatgggc tcagtttcca atatgaactg gaaagagatg gacgaggcat ttcctgcgtt 2533141 tctcgtcatt ctagccatgc ctttgacctc gagcatttct acaggaatcg cgcttggctt 2533201 tatttcgtac ccaattgtaa aagcggcgcg gggaaaatgg agagagattc atccgctcgt 2533261 catcgttttc gccattctgt ttttcatcca gctgtttatt ttataaggat agaccaaaaa 2533321 acccaaacgt cgccgtttgg gttttttatg taaacaataa agagacagcg gccgctaaaa 2533381 aacaacaggc ggcaaacgca tagtgcagga tgttgataca gctttttctg gcccgataat 2533441 attcatcact ttccttatcg gtgccaatta aaaaaggggc atccatgacc ttgtcaaaaa 2533501 taagcgtcag gatataacgg caaacccctg tgtataccag cagcgcaatc accttcagcc 2533561 aaattgggga aacaaatatg agaacagtga aagctgacag tagcatgtac atctgccttg 2533621 catactcgcc attcctcagc ataactttaa aaaacaactc cttatagcct gtgcagatcg 2533681 ttcgtctttt aaatatcctt tttgaatttc ggtataataa tggttttctt ctcatcctgt 2533741 cttttacttt tggcattccc gcctcctgac tcatcatcat cacaagtcct gcaagggcaa 2533801 gcctgctttt tttctcttca gtcacctcag cttcaaaagc cgtgaacgag gctgtctttt 2533861 tcaaactgcg gataactgag aaaaacaaaa ataaaatgcc aaaaagcgca agcaagtgcc 2533921 gctcagtaaa aacaatcagg atagcagaac cagcaaaaag aatagctctg acaagggtat 2533981 cgccaatcca tctcgaaatg gagcgcggct ttctgatcct gtcttgcttt aaggataaaa 2534041 agaatatatg aaggccaaac aaataacaca atagagcagt gctttctgcg aatgtgatga 2534101 gaacagaatg actgatcaag ggaaggacaa tgaaaaagag aagcagccat ttagccagcg 2534161 tggccagaaa agaatacaaa agcgcatacc gtttgagctg atagatgatt tccttctttt 2534221 gcagcaaaaa cactttgtcc gcttccatta aaaatgtacg aatcgaacct gtaaacatga 2534281 tcagcacaca cacagcatac agccatctcc attccgccac ttcagaccac tcataaagaa 2534341 ggcctcttcc gttcatcaaa tcaatatact gatagatgac aaaagcaatc gccggcaaaa 2534401 cgatatagag agcgactgtc cagtcaatga ccgcatgcaa cactttaaac tgatacttat 2534461 aatagtcaaa cagccttcga aaaaagagcg tacgcccgtt catagccgat caccttgaac 2534521 tgccttataa aaacagtcaa gcaatgactg cccctctaat ccggtcttgt cctgaacatc 2534581 ttttaacgtg ccttggagaa ataatgaacc tttctcaatc atataaaacc ggtcacagat 2534641 tttttccgcg gtatcgagta catgcgtgca cataagaatt ccggctccac gttctttttc 2534701 agccttaagc atgtccacaa agcgtttcgt cgatatcgga tcaaggccga taaacggttc 2534761 atcaatcaca tacatatccg gcttagagag aaaggcctgg ataagcatta gtttttgctg 2534821 catgcccttc gaaaaggtga caggcagctc atgtttgaca tgatctagcg aaaacgtctg 2534881 cagcaggctt tgggcccgat gcgcaaattc actctcttca atgccgtgaa gtgtgctgat 2534941 cagatccaaa tgctcccaca gcgtcagttc ttcgtagaag gacggatgct ccggaatata 2535001 tgcaaatgaa cagtcgttcc aggcaatatg ccctttaaaa tcttctgaaa ggccgagtat 2535061 cgccttgatt gcggtgcttt ttcctgcgcc gttagctccg atcagtccaa ccagttcccc 2535121 ttttctgact tccagaaaaa catcggtgag cacttttttt cggcttgtat acccggcctg 2535181 ttctattgaa gcttcaagca aatttgtcaa aactcactca cctccaaaat ttactacgaa 2535241 atagaataaa aaaagtttct ttaaccataa taatattgag ccgaaataca tagtaatcca 2535301 acaaggatgg ctgcccaacg cgaaattgga aaaaattaat aggagttatc cctagattca 2535361 tcactgcaat atcgtgtata atgagggcga attattttaa caattacaga tgtctgcctt 2535421 tgttgctatt tcgtacgcag ttgatagtcg tgagttgtgg ttagtcaagt ccatccgatc 2535481 ttatgatagg gagtggtttt ttgaaacctt caacaaaccg tatgctaact cgaatcaaat 2535541 cagtttacat gtttattcaa gaaaaaggtc ttgtgacaac acaggaactg gttgacgaat 2535601 tcggcattac acctagaacg attcaaagag acttaaatgt gttggcatat aatgatcttg 2535661 ttcatagtcc aagccgtggc aagtgggaga caacgagaaa gaaagtaaag attacctcat 2535721 aaattgaaaa ttacataggg ccgcctgaga gcggtccgat agataacagg gcgaagaaac 2535781 tactgagcct tgtttttgtg tgcttataaa taaaaccccg cattcggtat gcggggtttt 2535841 tgtcatgctt gcggctcatt tagcaaatga agctcttcct ctgtcagctc acggtattct 2535901 ccgggtgcca gagcgggatc tagggaaacg cgtcccatcg aaagccgctt cagataaacc 2535961 acttcattgc cgactgcctt tgccatttgc ttgacctgat ggtattttcc ttctgtaatt 2536021 gtcagatata taacggtatt gccactgtcg tttgttttga tttccgcttt tgccggcttt 2536081 gttttatagc cgccctctat gtagacaccc gtttccaaat cggaaatgtc ttcccgagaa 2536141 atctgtgatt ttaaatggac ttcatacgtt tttggaacat gctttttagg agaaaggagc 2536201 cgatgtgcga gctggccgtc atttgtgagc agcaaaaagc cctctgtatc tttatcaagc 2536261 ctgccggctg gaaatggctc aaatctcatc tcctccggcg tcagcagatc gaccactgtt 2536321 tgctgccggc tgtcctcagt cgccgacagc acgccctgcg gtttattcat cataagataa 2536381 atgaactctc gataatcaac cggttccccg tatacggtca cctcctgcgt atcaggatca 2536441 acgtgctcct ttacatcttt ggcaggtttg ccgtcgatca tcacggctcc agccttcaca 2536501 acggctttga cttcttttct ggaaccatac ccgctgttgg caagcagctt atcaagtctc 2536561 attcccaatc tctcctttat aaaagaaagc ccgcagcatg cgagccctca gtttcatcat 2536621 atctagttca tcagcctgca tgtctgcctt tcctaaagaa acctggcaaa cggcggccta 2536681 aaattttctg caaaaatcct aatcggtagc cgcaatacag gtagacagct ccgccaacag 2536741 cggccgcgat caccacaaca atcgcagctt gcatctggcc atcctgatag gaaataaaga 2536801 agcctaatac ccactgcacg attttcacgg caatacccat aatggctgat aagaccagca 2536861 tcaaaacagt tcgtttaaca agtatcttat acgaatagcc tgcatggcgc ttaatcatga 2536921 taaacccata taaaagggaa gcgatatatc caagcgccgt cgctaaaatc gctccgtcag 2536981 cctgcatcag cttgatcagc ggaacattca gcacaagctt gatcacgaca ccgatcacaa 2537041 ggctgacaac cgcaaatttt tgcttattga tgccctgcag aatagctgcg ttgactgtaa 2537101 acaaagagaa cagaattgcg acaggcgaat accaaagcaa aatgtttgcc cccagttcag 2537161 gatgaaggct ctctgacccg taaaagaacg tatacgtcgg tcctgacaat agagagatcc 2537221 cgacaacagc cggaataatt aaaaacagga tcgtctgcat cgtttgatta atctgctgat 2537281 ttaacagctt atagtttccg cttgtaaacg attcagtaat cgttggaatt aatgtcagtc 2537341 caaaagcagt tgctagggaa accgggatca tcacgagctt ctgaacatac agggttagaa 2537401 tcgcaagcat gtcctggctg atggcttgat gaccggcttc aatcatcgct ttgttaaacg 2537461 tatttgtatc aatatagtta tacaaaggga tggctagtcc gacaaaaacg tacggagcag 2537521 catagctgaa cagctcgaaa aacattttct tgtagcttag gtttgctgtc ggacccgtat 2537581 tcggcatcat cgccagcagg ctgcccttcc gtttgttcca ataaatataa agcacgacca 2537641 gccctccgaa ggcaccgatc agcgctgcga aggttgcata gcccacagcg atgacaaggc 2537701 cgccgttgaa aaccttcaaa atcaagaatg tcgcactcaa tagaaagatg atgcggacaa 2537761 tctgttcaac gacttgggaa acagctgtcg gacccatcat ttggtgccct tgaaagaatc 2537821 cgcggacaag gctcataatc ggtacgacca aaagcgctaa gctgaccatg cggatgacat 2537881 aaacgacatg atcaattgtc aggccgttat tatccttgcc tcccagcgat atttccgcaa 2537941 acatcggagc cgatagatac agaatgaaaa aggctatcat tcctgtgact agcataaccg 2538001 acatgcccgc cttgagcatt ttcctgcttg tctcataatc cccttttgaa ttatatttgg 2538061 aaacaaattt agaaacagcg gccggaaagc ccatcgtagc aatattcaaa aataaagtgt 2538121 attggttgta tccgtattga aataatgcac cgcctgtcgc cccgaccata atgctgaagg 2538181 gaattaaata gaccatcccc agaatccgcg atatatatgt accgagcgtt aatacaaacg 2538241 tgcctcttaa cagtttgctt gacatgtttc ttcatcacca ttttctacga agattcaact 2538301 tttctatttt accacaactg ggcatttaga cggtaataaa tacaaaagca atcctgtgaa 2538361 cattcatgtc cgcggcaaaa gacgtttaag gagcggcttt ctttcgctat aatagtactg 2538421 cggacgggtg tccgcacacg aaatgaaaag aaagttgatg ataaagatga aacaatatga 2538481 cgtaatcgta atcggcggag gcccttcagg cttgatggct gcgattgcag caggagaaca 2538541 gggcgctggc gtgttgctga tagataaagg aaataaatta ggacggaaac tcgcgatttc 2538601 cgggggcggc cgctgcaatg tgacgaaccg ccttcctgtg gaagaaatta tcaagcacat 2538661 ccccggcaac gggcgttttt tatacagcgc gttttctgaa tttaataatg aggacattat 2538721 caagtttttt gaaaacctcg gcattcaatt gaaggaagag gatcacggcc ggatgtttcc 2538781 tgtgaccgac aaagcccaaa gtgtcgttga cgcgctgtta aacaggctaa agcagctccg 2538841 cgtaacaatc agaacgaacg agaaaattaa atctgtttta tatgaagatg gacaggcagc 2538901 agggattgtg acgaataatg gcgaaatgat ccatagccag gcagtcatta ttgctgtcgg 2538961 cggtaaaagc gtgcctcata ccggaagcac gggagacggc tatgaatggg ctgaagccgc 2539021 gggccatacc ataacagagc tgtttccgac agaggttccc gtcacttctg gcgaaccgtt 2539081 cattaagcaa aaaacacttc agggcttatc actaagagat gtagccgtca gtgtgttaaa 2539141 taaaaaaggc aaaccgatta tcacacataa aatggacatg ctgtttaccc atttcggcct 2539201 ctcaggacct gccattctca gatgcagcca atttgtcgta aaagagctga aaaaacagcc 2539261 tcaagtgccg atcagaatcg acttgtatcc ggatatcaat gaagaaacgc ttttccaaaa 2539321 gatgtataaa gaactgaagg aagcaccgaa aaaaaccatt aaaaacgtgc tgaagccttg 2539381 gatgcaggag cgctatctcc tattcctgct cgaaaaaaac ggcatctctc cgaacgtatc 2539441 gttttctgag ctgccgaagg atcctttcag acaatttgta agggactgca agcagtttac 2539501 tgtcctcgca aatggcacac tgtcgcttga taaggcattt gtcacgggag gcggggtatc 2539561 tgtaaaagaa attgacccga aaaagatggc ttctaaaaaa atggaggggc tttatttttg 2539621 cggtgaaatt ctggatatcc acggctacac aggcggatac aatattacct ccgcccttgt 2539681 cacaggcagg cttgcagggc taaatgccgg gcaatacgcc cgttcttaat cattactctt 2539741 taaatctctt gccgccaaac tcacatttga acattccccg cattcatgtt agggtgagac 2539801 ttgttttgtt tcacctgatt gcggggtaat tttaagagag gaatgagctg ccatcgtacg 2539861 accatactaa gcctgcgagc aagatatagg cgtacacaaa aaattagagg gtgagaaatg 2539921 ttgaaacata tatctagtgt attttggatt gtgattgcaa tcacagctgc agctgtatta 2539981 tggggtgtta tttctcctga cagcctgcaa aatgtgtctc aatcggcaca agcatttatt 2540041 accgattcat ttggttggta ttatctttta gttgtctctt tgtttgtcgg gttttgtctc 2540101 tttttgattt tcagcccgat cggaaaaatc aaactcggaa agcctgatga aaaaccggaa 2540161 ttcgggttat tatcatggtt tgccatgctg ttcagcgcag gcatgggaat cggcttagta 2540221 ttctacggtg cggctgaacc gatcagccat tacgcaatta gctctccatc aggtgaaaca 2540281 gaaacccccc aagccttcag agatgcactc cgctatacgt ttttccactg gggtttgcac 2540341 gcttgggcca tttatgccat tgtggcatta tgcattgcct atttccaatt ccgcaaaggc 2540401 gcacccgggt taatcagcag cacactgtca ccgattctcg gggataaagt aaacggaccg 2540461 atcggaaagg ccattgactg tattgcagtt ttcgccactg ttgtcggggt gtcaacaagt 2540521 cttggtcttg gcgcaaccca aattaacggc ggtttgaatt acctgttcgg cattccgaat 2540581 gcgtttatcg tccaattggt tttaatcatt attgtgacag tgctcttttt actttctgcg 2540641 tggagcggac tcggaaaagg aattaagtat ttaagcaaca caaacatggt attggccgga 2540701 ttgttaatgt tgtttatgct cgttgtcggg cctacagtgc tgataatgaa ctcatttaca 2540761 gattctatcg gacaatacat tcaaaatatc gttcaaatga gcttcagact gacaccgaac 2540821 gatcctgaaa aacgcgaatg gattaacagc tggacgattt tctattgggc atggtggatt 2540881 tcctggtctc catttgtcgg cattttcatc gcccgtgtat ccagaggccg gacgatccgc 2540941 gaatttttaa tcggcgtctt ggtgacacct tgtattttga catttctatg gttctccatt 2541001 ttcggcgtat cagccatgga tctccagcaa aaaggcgcgt tcaatgtagc aaagctgtcc 2541061 actgaaacga tgctgttcgg aacacttgat cactatccgc tgacaatggt gacatcgatc 2541121 cttgcattga ttctgatcgc agtattcttt atcacgtcag ctgattcagc tacattcgtg 2541181 ctgggcatgc agacgtcgta cggttcttta aatccggcga attctgtgaa actcagctgg 2541241 ggtatcattc agtccgccat ggcggctgtg ctcctatatt ccggagggct tgccgctttg 2541301 cagaacacag cgattctggc agcgctgccg ttttctatcg ttatcctgct gatgattgcc 2541361 tctctctatc aatcgctctc aaaagaaaga agagagatca aaaaagcgga gaaactcgat 2541421 aaaccaagaa gtccaagagt gaaaaaagca tattaacaaa aaagatcttt ccgcgcctgc 2541481 ggaaagatct ttttatttgc gatataaaat aagggcggaa aaacagtaaa gctgctcgcc 2541541 gtctgggtcg cacgccgccg aaaccgtata tttgatatct atcagctgct cctccgatat 2541601 cccttttaaa aatgaattga tttccgtttg taagtctttt tcatgctctt catcaaatac 2541661 cgctaccttc agcattttat ccgctctcct ttctctatca atctattccg tttggaacag 2541721 cgttatgata gagaaatgat gattatctcg tttccggata aaaagctttc cgtatatggg 2541781 atttcctctg tggctcgccg ccgtgctgct ccactttcag cagcacggca taaacaatgc 2541841 gcatatggca gtagctgata aggctgacgc tgaaaaaagg gacaatgccc ggcaggtacg 2541901 caagcaagaa aaagagagca acagtcagcg caagcatagt aagcgtatat tgcaaatacg 2541961 ccacactgag caagagcgaa aatttcacat acagacgttt tttccagtca aaatggacaa 2542021 gcagcggaaa cacataaaaa agcatggata cgaacaaaaa gccaaatatc ataatggcga 2542081 agcgcaggat gtgcagaagg aaatgacttg gataaattaa ggccaaatca atataaatga 2542141 tcactccgat gagcgccagt acagcgccga gcagatttga acgaaaaaat tcacccttgt 2542201 attcctgcca aaacgttttg agcaccggaa cgttgtcctg cccctggatc cacttccgca 2542261 tgacagcgaa taaagccgcg gtcgcgggca tgatgccaaa cacgccgaga ccgagcaacg 2542321 taaaaaacag ccacagcaag tttgtatacg caaatctcat aatccattcg caaaaacgca 2542381 gcatccgtcc cagtgagcca tcatgttcca tggcgccccc tccttttttg cattatacat 2542441 tctgcatctg aaaaagctct ttcatgccga tcggcttctt ttcggcaacc gagcgccaca 2542501 ttccctcacc aaccgcgatg gagtaggctc cagcttcagc cccggctaaa atatcatagc 2542561 ggcgcagcgg gtctttccct aaaaaaagat cctcaagcaa aagcggatca cctccgccat 2542621 gccccccttc atttttgacc acttgtatcg tctgctttga ttcaaaaagc ggatagtatt 2542681 cgattgtctg ctcaggaaaa gcaaacggaa ttctggaagg ttcgtgaaat tcatttgatt 2542741 caatacgtcc ttttgtgccg ttgatcgtca gccggtagcc ttcatacggg gccgaaaaaa 2542801 taatcgagta gcttaacagt gcgccgccat catatttgac tgccgccacg tacgtatcct 2542861 cgatgtcaat ttcctcgtca aaaatacacg cgtcaggcct gtatgcagta tataagctgg 2542921 actggtctcc tgcttcaaga tgatcatcct ttatagaagc tttagaggaa cggggatgcc 2542981 accttgaata gtagtggcat ttttctttaa cacggcacgt cccgcaaaaa cgcccgtctt 2543041 cttccggcaa ggggttccac tcactgtccg gcccatagta attcaaggcg ccataagcaa 2543101 atacctcttc cggattttgc ccgagccacc aattgacgag atcgaagtga tgtgttgatt 2543161 tatggacaga aagaccgccg gaaaactgtc tcgacctgtt ccagcgttta aaatagctgg 2543221 cgccatgata cgtatcaata taccaattta aatcaacaga agtgaccctg cctatttttc 2543281 cgtccagaat catttctttt attttccgat gaaacgggct gtagcgatag ttaaacgcga 2543341 cggtgacttt tccttcgctt ttggcctccg cttcaagcac ccgattcgca tcctgcactg 2543401 ttgtcaccat tggtttttca gtaatcacat ctgtattcca ctgaaggctt tttacaatat 2543461 atgcgacatg cgtatcgtcc ctgcctgcca caatgacgat atcaggcttt gagacgcgca 2543521 tcatctcgtc aaaagcatct tcgctaaact caggcacgtg ggccagctcg ggaaatttct 2543581 tcttgcaaac ggcaaaacgt ttcggatcgg catccagcaa tcccgtaatc tcataatgag 2543641 ttgaaaaccg ctccatcagt ggtttgataa acatactgaa tgctctgctg ctcaatccgc 2543701 aaaagacgat gttcttcaat atcctcacct ctatcgggct tcagttagtt gagaaatcag 2543761 ctgcagcgct tcctctgttt tttcagcata cacagggata aacgccgcca tatcgcgatt 2543821 caattgaaaa gaatagccgt tcagctgttt tttccctttt tcgatctgaa cggcatagat 2543881 cgttttttct cctgtttttt tattaacagt tgtataagga gatgtttttt caggaggcaa 2543941 tccgtttaac ggctgaaaat tttccggatc atcgtaagct tgaaacatgt cttcaggcac 2544001 gatgaaaaca tctccctcat gggcggtaat ttcagtcagc agtttttcct gaaaagctgg 2544061 aaagatatcg accttcccgg cattctgctc ggcggccttt tttatttttt cctgtacgcc 2544121 agcctgcata tcagaaaaga gaatgacatg cattccgtcc ggcctgcttg agcatgatgc 2544181 caaaaagagc actgagacga tcacacacaa agccgtacgt atcctttttg tcatttcccc 2544241 gctgacctaa aaagaggctc cagctctgtc atagctaaaa taaacgcgcc ggctccgtgc 2544301 agatcgtttg tgcttctttc gcggctgaca taatagtcat agaaaccggc tgacgttccg 2544361 acacatatgt ctttgacgag aaacgctccg tcttctgatg tttcggtttt atgctgaatc 2544421 aagccttgat acgcttttag cagtgttgtt tcgtaagctc tgtctagata gcctttattg 2544481 attccttttg cgattgcgta catgtacaga caggatcctg agctttccag ccagttatca 2544541 gacctgtctc ccttatcaac gatctggtac cataaccccg tctctttgtc ttgatagcga 2544601 cagatgcttt taatcatgtc ctgcagcgtg tttttccaca catgacggtt cggatgcttc 2544661 ttcggcagct cttcaatcat gtcagcaaga gacatgacgt accagccgat ggaacgtgcc 2544721 caaaattccg gtgaacagcc tgtctcttca ttggcccaag gcattttttt cgcttcatcc 2544781 caggcgtgat aaaaaagtcc ggtttttgca tccttcgtat gctttctcat caatgactcc 2544841 tgaagcacaa cctgatcaaa cagctccgtc tcctgcttca gattggcata tttcagtgca 2544901 aacggccccc ccatgtataa gccgtcaagc cacatttggt aaggataacc gtctttgtgc 2544961 caaaaaccgc cctcagacgt ccggttcagt gttccatata agctgcgcag cctttttgcc 2545021 gctttgacat accgttcatc cttcgtctgc tcgtataatg gaaaaagaat gagacctgct 2545081 tgaatggcgt ccagttcatc tcttctaaat aatagattgc cattatcatc gattaagaga 2545141 tctgcataag ccttcgcata ctcaaaatac cgcttttccc cggttgcttc ccacagccgc 2545201 aatacaccgc ataagaaaac accctgatgg tagtgccagc ggtttgcagg tggcagctcc 2545261 tcgactgtgt acgtgttcat aatggtgttt gccaatgcct ccgcgtacgt aagaggcgat 2545321 tttacagcga ttgattgatc cattgatccc atccctttcc taataaattc cttcctcgcc 2545381 aaatttcttc gccaaacgat tcgctagcat gaccaaaatc agcccgaccg ccgctttaaa 2545441 tacgccgact gctgtactgt agctgaattg gccctgtttc agccctgcag tataaacata 2545501 cgtatcaaaa atttccgcca cttccctgtt agtcgcattt aacagcaaat acacatgctc 2545561 gaagccaagc tccagcgtgt ctccgatttt caaaatcagc aaaacgacga taacgctttt 2545621 aatggcgggc agcgtaatat gccacatttg ccgcagccgt cccgctccgt ccattttcgc 2545681 cgcttcatac agctgggggt caaccgctgt aatggccgcc agataaatga tcgtcgacca 2545741 gcccgcttcc ctccagataa cctgcagaat atacaggggc cggaaccatt cttcgttcag 2545801 cagaaaattg attttttcac cgccaaaaaa cacaatcagt tcattaatca agcctccgtc 2545861 taccgttaaa agcacaaacg aaagcgatac aacaatgacc caagacataa aatgcgggat 2545921 ataaatcagc gtctgaacaa attttttaaa gagagcaatc cgcacttcgt tcaatagaag 2545981 cgccagcagt atcggcaccg ggaaaaatat ggccaggttc aaagcaaata acacgagcgt 2546041 gttttttaac aagagaaaaa atgtaggctc agtaaacagc ctgataaaat gcttcagccc 2546101 cacccactca ctgcccaaaa tgccgaggaa cggctgataa tcctgaaacg caatcacaat 2546161 tccccacatc gggacatact taaaaagcaa aaaataaata caccccggca aaatcatcaa 2546221 gtacaaatat ttttgttgaa tcagcttgat tagtaagcgc tttctttttt cttttttaaa 2546281 aatgactgca tcaacagccg gcgcttgcgc ttctgctgtt ttcatttttt cctagcctcc 2546341 tttcacggat tcttgcattc actgtagcgc agcaggcaaa agtccgtcta caatcatatg 2546401 atcacatcct gttttatccc tttataatca agggttcagc cggtccacct gaaaaaaaga 2546461 caccgatatt agaaaatgat tattgacaat atctatcaat ctttggatta attgtattaa 2546521 ggtgaagtgg atgttatgaa atggggggtt ttatgaaaag aagccaatac aagttttact 2546581 acaaactgat cacgtttttc tgcctgctca gcaccattcc ggttattttg gtcggattat 2546641 tttcgtacga gcactctcag aaaacggcta tttccaacgt ttcggaggaa aaattcgaca 2546701 cactccagca gacccagcaa agcatcgagc atatattgaa aaccgtcgat cactctttaa 2546761 cccactatgt gagttcgccg cctctccttc gcacattgtc cgagcctttg cactcagacc 2546821 aatttcaaat ctataaccaa gtgaaccaag agctcaatta tctgcaaagc tttgataccg 2546881 atctgtccaa catgacgtta gtcagttata cgaaaaaatg gtacatgaac aattccggtt 2546941 tgtaccgttt gaatacagac actcttcatg aagcagcctc agcgtacacg aaacaaaaag 2547001 cgagccgctc ctattggacg cttgaggaaa acaatcattt gatttcaacc aaagaaggca 2547061 cagcagaaaa ctgccgctac aatatcaatt taattaagca gcttcctttg aacagcacaa 2547121 atacaaaggg attggccgcc gcaagcatcc cgagctgttc gcttgtcaaa aatatgcccg 2547181 gctattcaaa cgccaacaac ctgtttatca tcgatgaaaa aggcctcatc atccttcata 2547241 acaatatgtc tgacgttggt gaatctcttc ataacgacgg ctttgtccaa aaagtgctgg 2547301 cgcaaacggc caatagcgga cagtttgaaa cagtgattga ccggattcat tataaagtca 2547361 cctatcaaaa atctgactat aatgcatgga cttatttttc tctcgtttcc ctgcctgagt 2547421 taaaaaaaga agccaaatca atcggctgga tcacttttgc agtatgcctc attttgttaa 2547481 cgctttcatt gctgttctct tggcttggct cccgccattt ttacaagccg atcagggtgc 2547541 tttacgaatc attcgcaaga catggagcca tacaagagaa acaacagcct cctcaaaatg 2547601 aatttgagtt aattgaacag agctttaagc agctgaagga cagaaatgac gaccttgaag 2547661 aaacgatgaa gcagcaggcc actcatctgc agcaatattt tatggtcagg cttatgcttg 2547721 gaaaactgac ggatgaggag gttgataacc gttttgaaag cctcggctta aagcaaaatt 2547781 ggcggcacct tgccctgctt gtgctccaaa ttgacacact gaatcatacg ccttatgaga 2547841 aaaaagatat ggatctgctt ttgtttgccg tcaacagcct gattgagcgc aacatcccga 2547901 cggacaaaca tcttgccccc gccgtagttg acaaacagca ggcgacgatt ttgatcaatc 2547961 aaagcgggac aaaggaagaa ttcatggctg agctgaatga gactgcaagg atgattcagg 2548021 aaaaagcgga agctgagctg cagctgtctg tcagcatcgg catcagccag ccgtttgatg 2548081 tgctgacaaa agcgaaaaca gcctatgcgg aaggctcaga agcgttgaaa tatcggctga 2548141 aagcggaaaa caagtcgatc atcttttacg aagaccttga ccagaaaaaa accttcaaaa 2548201 cccattttcc aaagcagctt cagcatgagc tgttcgatgc tgtcaaagca ggagacaagg 2548261 agaaagcgga taaatgcctg cacgcgattt tacaagccat tttcacccag aacaccaacc 2548321 cgtatcaatt tcaaatcgcc atcgcccgtt ttttgaacca tgtgattgag ctgatgcatg 2548381 tgcttgggat cgaattgttt gagcttgaag aaaacaaaat gctgtatgac caaatttttg 2548441 agctgaaaac gttcgaggat accgaaaact ggctaaagaa tgagtttatt gatccgatga 2548501 cagacaaagt gaacgcccgc gcggatgccc agtacaaaaa tatttccgac aacatcattc 2548561 atatcatcca tcatgagttt gaatccgaat tgacactgga cgaaatcgca cgcaggctgc 2548621 attacaaccc aaattattta agcagtattt tcaaaaaaga aatgggaatt tcattcagcg 2548681 agtatgtctc aagctaccga caccatatgg cgaaaagctg gcttgccgaa accgacatgg 2548741 cggtcaagga cattgccgaa aagctgaaat ataaaaactc ccaaaacttc atcagatcat 2548801 ttaagaagct ggaagggatt acaccgggaa actaccgcca gcaaaaaaga agcatgtaaa 2548861 aaacccaaaa ccgcttgcgc gttttgggtt tttccaatgt tattttgctt gtttaaacgc 2548921 ttcttcgtat tcctgaataa tttgttttcc tccgcttgac tcccattttt ccacttcttt 2548981 atcgaactgg ctttctgtga tgtctccaat catatatttg taggtcgcgt catcaatgat 2549041 tttcttcagt tcgtcacccc gttccgactc cgatgcggaa tacaggcttt cagccgggtt 2549101 tgagacgata atcttttcat tgtcctcggt cagctcctcg tacgccgtcc gaagcggatc 2549161 tccagtgttt tttaagtagg ctttatcaat ggcaattaaa gcggacagcg gctgaatatc 2549221 agtctgccag tcttttacct ggctttcttt gcgtgtaaac gttttgtcct cacctttgtt 2549281 gtaatgaacg ccgtcaatgc cataagtcat caggctatag acatcttctt cggcaattcg 2549341 gtcaaaaaac gccaagatcc gtttaagctc agcttccgtt ttcacactcg ttttcgggaa 2549401 agcaaacacg ccgttatggc ctcctgatgc ccatacccgc tctttcccat ctgggccttt 2549461 tatgcggttg atgatctcga gcttcatcga tttatcagag gcatggtcgc gcagattgac 2549521 cgcatctacc atattgccaa tataaattcc ggcttttcct tgagaaaaca gctcttgctg 2549581 ctgggttttg cttgtgacgg gaaaatcctt attcatatac ccgttatcac gcagcttttt 2549641 catatagttc atcgtgtctt tgtattcctg tgtcatgaaa tcaggcgtga atttgccgcc 2549701 cgattccttc caatctgtcg gcatgccttc atacgagcca atcgttttaa acgcgccgta 2549761 aatcaagtca ttacggtctg ccagcccgaa tgtatcatct ttcccatcct tgtccgggtc 2549821 gtcctccgta aatgctttgg ccacttcata aagctcatcc aacgttttcg gggttttcaa 2549881 atttaaattg tccagccagt ccttccgaat gacgatcccc tgtctggaaa gcgggcgctc 2549941 tctgtatatc ccgtagagct tgccgtcaat tgtcacattt ttattaatga gtttgttcat 2550001 tttgtttaag ttgggataat ccttgatata atcgccgatt tcccaaaaca ttcctgaccg 2550061 aaaggcattc atgactgacg aatttttaat atcctggatg gtcacgattt gcggaagatt 2550121 gccggctgca agcgctgcat tcagcctgtc ttctttcacc gcgtctggaa cccaggtgat 2550181 gtcgagttct gtatttgtca gcttttcaat ttctttaatc gccctgtctt tcggcggctg 2550241 ctggtgatac aaaatcgcca tccaagacag ctttaccttt gaatctgggc cagctttgcc 2550301 ttcagccgaa gactgatcag ttcctttaca gcccgccagc actccgccga gtgccagtac 2550361 aagcacaatc aaaagcaccc tccatttgtt tcccatcgta cccctccgtt tcatatttct 2550421 ttatcctttg acagatccca gcaaagctcc ttttgcaaaa tgcttttgta taaacggata 2550481 gacaagcaga acagggatgg tcgccaccac tatgaccgcc attttaatgg tttgctcagg 2550541 cggcgggctg cccgacccca tttcagacat atccccctgc ataccgcttg atacaatgac 2550601 gatttggcgc agaagcacct gaattggcca ttttgctgaa tcatttaagt acaagatcgc 2550661 tgtcatatac gtgttccaat acgtgaccgc ataaaatagt gaaatcgttg cgatcgcagg 2550721 aagagacagc ggcagcacaa ttttaaagaa tatgcccaga tcattgcacc cgtcaatttt 2550781 cgcggactct tccaggcttg acgggatatt ttgaaagaag tttttcagaa tgatcaggtt 2550841 aaaggcatta atggctgtcg gcaaaataag cgcccagtaa gaatcgagca atccaagcga 2550901 tttgaccaca aggaaagtcg gaatcatgcc gccgctaaac agcatcgtaa atacgacgag 2550961 aaacatgagc ggctgccggc cgattaaatc acggcgggat aacccgtaag ccatcagtga 2551021 cgaaagaaac atgctgaccg cagtgcctat cactgtcaca aacacagaaa caagcaaact 2551081 cttataaata atatctgttg aaaaaatgta gcgataagca tctagcgaaa aagtggtcgg 2551141 tattaaaata aattttttcg acacgacttc ttctactgtg gcaaaggatg ctgcgataac 2551201 atgaatgaac ggaagtacgc atattaaagc gaacatcagc aagaaaccat aaatcaacat 2551261 atcaaacaga cggtttttca gtgaatgtgc gatagctccc acctcccttt gtaagcgtta 2551321 tcatattttt ggaaaccgag ctcagcatgt gacgatatcg tgtctaaaat gtagcaaatc 2551381 tgtgattgcc atgtctataa tcatttgaac agtgtccccg gccgggcggg ggctgccgcg 2551441 aattgagacc gataacaaaa gaaaaagagc ataatcttag aaaatgatta tgctccgttc 2551501 tcctcctcgt tcagaagttc agccgtattg atttgtggcg aaaacccaag ttcattcacg 2551561 gcagattcaa tggaccatgg ccggcccgga ttatcagaga cggcgtaata agtgccatac 2551621 cggatgttgg tctcaatggc ggctttgaaa atcgacagca gatcggggtg agaaagcagt 2551681 gtctttttcg tccgttcttt ttcatgcagc gtatccattt catctgtcac gactgttccg 2551741 attcgaaggt tgattactga tagcttattt tccaaataaa acaaatggcc gatctgttca 2551801 gaggtcagct ttaatacacc gtacaagttt tttgacagcg gataatcgct tgttgtgatt 2551861 tcccgtccta agagcgagcg cccgtctttt tcatatacat ctgtgacatg attgctgctg 2551921 gcgaacacga gcttttgaat gccgagctcc gctgccgcac ggcacagata atagcttgcc 2551981 ctatagaaaa catccgtcat tttttcaaac tcagcgatgt ccataatatc gtatttgatt 2552041 ttcacagcga gtaaattcaa gatggcatcg gtatcttttg gaatcttctt caacagctcc 2552101 tcataatttg ccgcgtcagc ctgaatggaa gaggctttgc catcgaaatg atctttatca 2552161 agcacagtca cttcatagtc tgaaataagc ccttcagcaa gcagtctccc aatcacacca 2552221 tttccgccgg cgatcagcac ttttttcacg atgttcactc ccctttttta tagattgccc 2552281 attttcggcg gggctgacac ttttttggca ctcacattct taggcttatt caaaagtcac 2552341 cggcagctcc tcaagcgccc gaaatccaaa aagcggccga taccgccatt caaaatccgc 2552401 aagattaagg ctgggcattc gctgcagaag agtgttaatc gcaatttgcg cttctaatcg 2552461 tgccagcgag gaccctaagc aaacatgatg gccatgcccg aatgaaagat gcggattagg 2552521 acttctcgta atatcgaaga catcggggtt cgtgaatatg ctagggtctc gattagccgc 2552581 tcctaacaaa agatagactt gttctccttg acggatcgtc accccgcaga tgtcaatatc 2552641 ctctgacgca actctggctg tcatttgcgt ggggctttca tagcgtaaac attcctcgac 2552701 tgcggtacca ataagatctg gattttctct cagtttcaaa agctgttctg gatgctgcag 2552761 cagacaaagg actgaattgc tgatgagatt gaccgttgtc tcatgtccgg cgatcgccag 2552821 caatatgcac gtagatgccg cctcctcttc cgtcagctta tccttttctc tccccttcaa 2552881 gagcatgctg atcatatcct gttgagggtg gcgttttctc ttttgaatca gctctttgaa 2552941 atatgccata gcctgcacag ccataatatt gccctctgtt aatgcctttc ttgagcgggt 2553001 aaaatcaatc gtttgaatga gactcgcagc ccactccttt aattgctccc tatcttcctc 2553061 cggtacacct ataatgttag ctatgacaaa acttgctaaa ggaaaagcaa agtccgaaat 2553121 gacctccatc ttttttttac cttgcacttg atcaagcaaa tgatggacag tttcaatgat 2553181 atacggctga taactctctg tcgttctcgg cgtaaacgct ccgctggcaa gcgtccgcaa 2553241 tcgtctatga tcaggctggt tctgaaacag catcatttga ttttgcacat gtgaaaggtc 2553301 ctgatatttg gttgagctct caggcagcgg ggtgcggact ttgaatctcg catctttcaa 2553361 aatagcagcc gtttcttcat atcctgtgac ataccagccc gggtatttta agaaactccc 2553421 tttatagata ggatgaacag ctcgcaatgt gtcgtaaaaa gaatatgggt ttttcaaaaa 2553481 ctcagaagat gcagttgacg atgcaattgt cacgtgattt tctcctttct gttcaaaaat 2553541 aaaaacaatc gacatcatac cgattgcttt tattgattct ttcagctttt cgcacttaaa 2553601 ctagccttca tttcttcgac tgattcaact tcaaagccta aatcactcag cattttatga 2553661 tcctccgtct cctcttgccc ggcagttgtt aagtagtctc cgacaaaaat ggagtttgcg 2553721 gcgtaaagcc ctaatggctg caatgtgcgg agattgacct ctcttcctcc ggaaatgcga 2553781 atttcttttg atggattgat aaaacggaac agcgccagca cttttaaaca atacagcggg 2553841 tttaattcgt tgacgccttc taacggcgtg ccatcaattg catgcaaaaa attcacagga 2553901 atggaatccg cgtcaagagc cttcaagctt ttggcgatgt caatgacatc ctgtttcgtc 2553961 tccttcatcc cgataatggc gcctgaacac ggagacagcc ccgattcttt tgcgatttca 2554021 accgtattga ctctgtcatc gtatgtatgt gaggttgtga tgtttgaatg gtttctctgt 2554081 gacgtattca aattatgatt atagcggtct actcctgcat ctttgagccg cttcgcctgc 2554141 tctggcttca acagtccaag acatgcacaa atcttcagtc catacgtctc tttaatttcc 2554201 tgaaccgcat ctacgacctg atccacttct ctgttagacg gacctctgcc gcttgccacg 2554261 atacaatatg tgccgatatt cagatcgtgc gcccgcttcg cgccttcaag cagcgtttcc 2554321 ttattcacca tccggtaaga ctcaatcggc gctttcgaaa tcgcagactg tgaacaatag 2554381 ccgcagtttt ccgggcagag cccggatttc gcattcataa tcatattgag ctttactttt 2554441 tttccgtaaa agtgttttct gatgtgaaaa gccccgtgca ttaatagcaa aatatcttca 2554501 tcaggacaat gtaatattga aagcgcctct tcgtcagtca cttctgctcc agccagcacc 2554561 cggtctgcga gttccatcca ttgattcatt ctcatacccc cacttgattc atcagtaatg 2554621 atagattgat atggtctttt accatatgta gaaccgtttc tttcgtcacg ttggcaagct 2554681 ttggcgtaac ccctaaaatc ggcacaccgc ataagcgctc aatcatctca ggattggttt 2554741 tttcatcttc atcaggagag tcactgattc cattgatgat aattccggcg attggaagcc 2554801 ccatgctttc tgcatatttg acagttaaaa aggtatgatt aatggttcca aggcgaggac 2554861 gcgccacaat aatcatggga agctgcaacg cttttatgac atgactgacc aaatagtcct 2554921 ctcccaatgg cacagaaata ccgcctgcac cttctacgat gaagcattca tgtttttctc 2554981 taatccgccc ccaatggctt aaaacctctt ccatggtgac agtctttccc tcaagtttcc 2555041 ctgcaacgta tggtgcaagc ggcgccttga aggcaaaagg cgtaatgtct tcatgagaaa 2555101 gactggtctg cgacatatct ttcagcaaac ttgtatcact atctggatga tggcgcgata 2555161 tcccgcttaa aaatggttta tacaccccga catgtctatt attgtctttc aataaggcag 2555221 caagaccgct ggatataacc gttttcccta cttctgtatc agttcccgtc acaaaaaaac 2555281 ccctcaaatg atgtgcagct cctttccgat tgaatgaaat gtttgcagca aatgatcaat 2555341 atcacccata ctgtggtcag acgtgattgt aattcgaatc cggctttcac ccggcgcaac 2555401 ggttggcggc cgaatggcag gagcataaat tcccttgccc tgcagttttt cagcaaatag 2555461 gaccgtttta tgggcatcgc caatgactac aggaataatc ggtgtgtgat ctcctttcac 2555521 cacataaccc atattcttca gactggttct gatcatgctg atataagaaa ataaaagctg 2555581 tcgtttttcc ctgctggctt caatgatgtt gaaagcctcg tgagcagccg cacagctggc 2555641 tggcggaata gcggtttgaa agataaatgt tctggcatgg ttcagcaaaa agtcgatgaa 2555701 gaccgctgat cctgccgcaa aacctccttc cgcgccaaca gctttgctta aggtgccgat 2555761 aacaatgtcg ggacaaacac caaagtattc actcgttcct tgtcccgaat cgcccaaaac 2555821 tcctgttgcg tgggcatcat caacgaccac gaaggcatga tagcgtttcg caagtgagat 2555881 gatctgatca agaggggcga ttgtgccatc catgctgaat actccgtctg ttacgataaa 2555941 acggcgctga taacgctgtg tttcattcag cttgttttca agatcattca tatcaatatg 2556001 ccgataaaca actgtatcag ccttagaaag tcggcagccg tcgatcatac ttgcatgatt 2556061 gagctggtca cttaaaatga catcttcctt ttctggcaag gatgaaagga caccgacatt 2556121 ggccaagtaa ccgctcgaaa acagcagggc cgcttctgtc agtttaaagc tggcaatctt 2556181 cttttctagc ttttcatgcc agaccgaatt gcctgtcgtt aaacgtgaac cgctgcttcc 2556241 tgtcccaaat tgctgcaatg ctgtttgggc tgcatcgatc aaacgtctat cgcttgcgag 2556301 ccctaaataa ttgtttgagg accagaccgt ttgattttcg ccatcaatat tcctctctgg 2556361 aaccggcgct ccatccattg accgcaggtt acgatgtacg ccggcttctt tcattctgtc 2556421 taaccgctcg tttaaccagg aatcaatctt caaggctcgt aacctcgtgg atcgcttgtt 2556481 tcataatggc aaccatttcc gagagctctt cagctgtgct ggcaagagga ggaagaaatg 2556541 caatcacgtc cccaagcggt cttgtcagca ttcctaactc tctcattttt aaggaaactt 2556601 tgtatccaat ccgccgatca gccgggtaag gttctttagt ttcctttgat cgtacaagct 2556661 ctgcaccgca cataaagcca agctgccgaa tatccccaac atgaggaaga gcgtgcagat 2556721 cttgaagaag aaaatggagc tttttacttt tttccgctac ttgttccaca atgttttcag 2556781 attcaaataa tgccagattt tcaagcgcaa ccgcacagcc aagctgattg cctgtatagg 2556841 aatggccatg gaaaaaggtt tttaggtttt cataatcatc atagaatgcc ttatagatgt 2556901 cttcagtggc aaacgtaacg gcaattggca aatagcctcc tgtaatgcct ttaccggcag 2556961 ccatcagatc aggctggaca ttctcgtgct cgcacgcaaa catttttcct gtacggccaa 2557021 agcctgtagc gacttcatca acgatcatta agacatcgta tgttgtacat agctcgcgca 2557081 cgcctgccaa atatccttcc ggcatcacga tcataccgga cgcgccttgt accattgatt 2557141 caatggaaag cgcggcaatt tcctcatgat gttcctcaag cagctgtgca agctctcgga 2557201 ggcactgatc acggcactca tcaggatcac cgctttcaga acgatacaca taaggaatcg 2557261 gggccttgta actctcgaac atcaacgggc cgtatacgtg gtgaaaaagc tcaattgaac 2557321 cgacactgac ggcgccaatc gtatcaccgt gatacccgtt tttcattgcg atgaattttt 2557381 gtttctcggg cttcccgatg ttcttccaat actgaaacgc catttttagg gctatttcca 2557441 tcgcctctgc gccgctgtct gaataaaaga cccgcgtgag cttttttggg ctgatgtcga 2557501 ttaatgtttc ggcaagctgg gttgctggaa cattggtcat gcccaataac gtggagtgcg 2557561 caatttttcc gagctgtttt tttatggcgt catctagttc ttttttgcgg tgtccgtgga 2557621 cattaagcca aaccgatgaa aaaccgtcat agtattcctt gccgtttatg tctttgactt 2557681 tgattccagt cccgctttcg atgattaagg ggttttcatc ataatctttc atttgggtaa 2557741 atggcagcca gaggtgcttt ttactttttt ctatcaaatc atgagtcatg atcttcctcc 2557801 cactctatta aaataggctg cttctccagg tcatgtatgt acgtgtttac atcattggat 2557861 ccatcaataa aaaagactcg gcagccctct tcagtcccgt attctttcat tgctgtaata 2557921 cgctgatagc ccattttctt acccgcaaca tagcctgtta tgtaatccgg atcgtccgac 2557981 cagcataatt ctgcaacgac tgccgggtgc cggcttacct ttgaagcgag cgcaagggcc 2558041 tcttttattc ttgaatgagc tggcacgtga ctgtgaagcg cccatttttc aaaattagcg 2558101 tccggccaat ccattctgga gacccgcacc cctttttctt ttgtttgatc cattcgcttg 2558161 cctgtatgaa tatcaaacaa caccgcaccc ctgacatctg accattcagg gatttgttca 2558221 tatgcttttt caatcacgtc tcgtgaaacg ccttcttttt ccaataacaa tcgggcaagc 2558281 ttttgtcctt cttccgggca gctcacttca ttcgtatgca caggcaatgg ctgaatggtt 2558341 tttatcgatt catgtacctc ttcaaattga atttgcataa aatcaggttt tcctcttgaa 2558401 tgggataacc ctttttctaa taaagcattg actgtatgct tcatctcatg gaaaggaata 2558461 agccgttctc cgccggatat atgctttccg ccgtcttcat gagatccatt cattgaagcc 2558521 ctcattctga cactataaaa agtttcttct tgcatcattt ctcgcccttt cactgataac 2558581 tgaagaacgt gtagcgcttc tcacctaaat tgttaaccaa ttatattcaa aggttaacaa 2558641 ttagaatata ttattctctc ctgtttctgt caatagaaga aaggatcgat ttatggcagt 2558701 tggttaaaag gaaacaaaaa gaccgttttc acacaaaacg gtctttttcg atttcttttt 2558761 acagtcacag ccacttttgc aaaaaccgga cagcttcatg ccttataact gctgtttcga 2558821 aatgtcccga agcagaacgg accactcggt agcaatcagc agctccctgt ccagcataga 2558881 cagctgtcaa ttctttttcg attttgtcca cgccctcagc cggcgttaac cgatcgtgta 2558941 caccaacaag actaaggtgc gggcgcggcg cgatcaggct ttggatctcc gatgcggaaa 2559001 aatgctttgc aagcgatggg acgtaataat aaaagccgtg cctgtcaaga ttctgtgttt 2559061 tgatcagcac gtgatgatcc acctggctgc acaaatccac acacacctta atccggtcat 2559121 cgagcgccgc tgtccaccac gccatcaaac ctcccataga catgccgatg gttccgatcc 2559181 tgtcaggctg aacatcagag cgtgactgca tatagtctaa cgcacttaaa ctgtcataaa 2559241 tcatcatccc ccacatcact tttccggtga gaagcatttc tttaaatatc tcgctttccg 2559301 cttttccccg ccgatctcca aacccccaat gatcaatcgc aagaacgccg tatccgagtg 2559361 aagtaagctc atcagaaaaa gaaggcgttt tcaaataatc cgctccctca atcagctcac 2559421 tttttcccct atcatactgg cctccatgcg aatgctgaaa caatacggct gggcacggtc 2559481 cttctgtttt cttcggcttc acaaaataag cgggcgcctt ttcatgtcca tttaaatcga 2559541 gcaggagcgt ttcaacgata ttttcttctc tttcttcaat acgtaatgtc tcaacactga 2559601 ttggcctccg atcaggcaaa tcaccaagca atcgaaacag ttgctttctt ctttcggctc 2559661 tcatcccatc acccttcctt attcgcttac ttcacattta cgagacagat ctgggttccc 2559721 ctttattttt ccaacataaa tcacatcatt tactaaatat ttagtaaata ttatggaata 2559781 tttcgaaaac aattattgta accgcttact tttatatgat aatatcaatt tatcaaaaac 2559841 agatgagtta atattttact aaatagatga gagggatacc catggttcgt attaaagata 2559901 tcgccttgaa agctaaagtt tccagcgcaa ctgtgtccag aattttaaat gaagatgagt 2559961 cgctttctgt tgcgggcgaa acgagacaaa gagtcatcaa catcgctgaa gagcttggtt 2560021 atcaaaccgt tgccaaacgc cgaaaatccc gcgggcaaaa acagcgggct cagccgctga 2560081 tcggtgtgct gagctgtctg tcccctgatc aggaaaggca ggacccttat ttttcttcca 2560141 ttcggaaagg gattgaaaag gaatgctttg aacaggaaat tttcattaca aattcgattc 2560201 atctcggctc ctttcaggaa catatctttc gggaattgga tggtgtcatt gtcatcggcc 2560261 gtgttcatga tgaagcggtt aagcatatca gcgggaggct ggagcatgcc gtatttatca 2560321 atcattcacc agatccgcaa gcatacgatt cgattggcat cgattttgaa tcggcttcac 2560381 gccaggcgat tgatcacctt ttcgacttag gctacaaacg gttaggctac attggcggac 2560441 aagaaaaaga gcatacgctg aaggacggcc aaagcattcg cagaacgatt gaagataaac 2560501 gcctgaccgc ttttttggag tcagccgccc cccagcctga gcatgtgctg atcggagaat 2560561 acagcatgcg tgagggctat cgcctgatga agaaagcaat cgatcaaggc catctgccgg 2560621 aagcattctt tattgccagc gattctatgg cgatcggcgc attaaaagcg ctgcaggaag 2560681 ccggactgca agtgccgcgg gataccgcaa tcgtcagctt taacggcatt gaggaagctg 2560741 aatttgccag cacgccttta acgacggtga aggtatacac agaggaaatg ggccggacag 2560801 gcgtaaaact gctgcttgac cgtctcaatg gccgaacgct tcctcaacat gtcaccctgc 2560861 ctacaacatt aatcgtaaga caaagctgcg gatgtacagc aaaggaggtg acataagcaa 2560921 agattcatca cgatgataag gaggaaaaga tgaaacacac ttttgtttta tttctctctc 2560981 ttattctgct tgttctgccc gggtgttcag cagagaaaag ctcagcagat accgcaaaaa 2561041 agacgttaac catttattct acaatgtcaa ccgacagtga aagagatacg ttcagaaaac 2561101 tagcggcagc attcgaaaag gaacacagtg acattcatgt cagccttcat ttcccaggca 2561161 atgactatga aaatatgatg cgtgtcagaa tggcggccaa tgatttgcca gatctattcg 2561221 atacacatgg ctgggggaaa atcaggtacg gagaatatac agcggatctc cgggatatga 2561281 aatggactca agatcttgat cccaatttaa acagcatcct caaaaataaa agcggaaagg 2561341 tgtatgccta tccaatcaat caggcaaaag acggtctggc gtataatcgc aatattttag 2561401 accgttacgg cattgctccg ccggaaacca tggatgactt tatcaaagca ctgagaacga 2561461 ttaaagaaaa gagcaaggga agcattgttc ccttctggtt tgccggatat gacaaaagct 2561521 cattcgccca atattacgac caattcgcta cacctcttct catcacagac cctgcccata 2561581 atgaaaaaaa acagctcatc aacggcactt ttcaatggag taaattcact tatttatcag 2561641 aaatcctcaa acaaatgcag aaagaaaaat tgatcaatat cgacgccgtc acggcaaaaa 2561701 aatcacagct cattgaatta atggcccaaa acaaaatcgc ctttacaatg caaggcggca 2561761 cactcggcca agacgttgcc cagatcaacc cgaacgtcaa ggtcggcatt atcccgacac 2561821 ctgccatcca tcccggtgat gacccgatat ggatcggcgg tgaacgctac acccttgcag 2561881 catggaaaga ttcgcctcaa ttaaaagagg caaaagattt tatcgcattt atggcccgcc 2561941 cggccaatgc caaacaaatg gctgaagcca catcgcttcc ttcagggctg accaatgtga 2562001 aagctgatat tttctacgca aacgattatg agtattatca agatgtcaaa gtcgagcctt 2562061 acttcgaccg gttatacttg ccaaacggaa tgtgggatgt cctgggcacg gttgggcagg 2562121 agctcgcggc tgacattttg gcgcctcaag acatttcgca gaagctggga agagaatata 2562181 aacgactccg ggagcaatcc gaaacacagg gagctgaaaa caatgagtga gatcgcaagg 2562241 gacgttcatg tgaaacaggt taagccaaaa aagcagtcct cactttggtg gatgtacatt 2562301 cctgctttgc tctccgttct ggtctttatg atttacccgt ttgtgaaagg cacattgatt 2562361 acctttacaa actggaacgg attttcacaa gtctaccaat gggttggatt cgcgcaatat 2562421 gaaaggctgt tttctgatcc tgatacttgg catatcttaa aaaacacgct gcattacggg 2562481 cttggcagca ccttttttca aaatgtggtc gggcttctgt acgctctcct cttaaatcaa 2562541 agcattaaaa cgaaagcggt aacaagaaca attgtgtatt tgccggtgat gatcagcccg 2562601 ctcattatgg gctacatttg gtactttttc ttctcctatg acggaggcgc gctcaacgat 2562661 ttgctcgggg tcttcggcat cagccctatt aatgcgctcg ccagtccctc gctcaatcca 2562721 tggatcattg tcatgattaa cacctatcaa tatgtcggga tcgctatggt tgtctactta 2562781 gccggtctgc aaagcattcc gaaagactac tatgaagcgg cgcaaatgga tggcgcgaaa 2562841 caaggccagc agttttttac catcacgctg ccgctgttaa tgccctccat taccattaat 2562901 atagtcatca acattatcgg aggcttaaag ctgtttgacg tcatcattgc actcaccgca 2562961 ggcggccccg gaaatgcgtc acaatccatg tccacgttta tgtatgattt gtatttcaaa 2563021 cggcaggatg ccggctatgc cgcaacgcaa ggcatattta tggcatttgt cattttgatc 2563081 atcagctttt gcgcgcttgc gtactttaaa agaaaggaga cggaaatgtc atgagagccg 2563141 cccgtacaaa aagcatgcgg atcattacgc ttcttgcagc cattgtggcc tgtgcgcatt 2563201 ttattccttt ttatatcctg ctgaccactt cattgaaagc aaaaggagac tacagttcga 2563261 aatggatatt tccagccgac atctcctttc ataatttttc agaggcgtgg gagcgcgctt 2563321 cgctaggaaa ctcttttata aacaccatga tcatcacagg tttttctgcc ttgttattaa 2563381 ttatattcgg ctcacttgcc gcctacccgc ttgcccggcg ggaaacgaaa ctgaataaag 2563441 ccgtttttgc cttgctgatt tccattatga tcatccctcc gttaacgtcc atggttcctt 2563501 tgtaccgaat ggtcgtggac gccggaatgg tcaatacaca cgcaatcgcc attttcatca 2563561 atacagcggc ttacatgccg ttaaccgtat tcttatattc aggctttatc cgatcgacca 2563621 ttccaaaaga gcttgtagaa gccgcaagaa ttgacggtgc aggcatgctg aaaatctttt 2563681 ttacgattgt gtttcctctg ctgaagccga tcactgcgac catctgtatc atttcttgtg 2563741 tctttatttg gaacgactat caatttgcca ttttcttttt acaagatcaa aaggttcaga 2563801 cattaacagt agccatggca ggttttttcg gagaaaacgc aaacaacctt catttagttg 2563861 ccgcagcggc acttatggca atgctgccga tggttgttct gtttttggcg ctgcaaaaat 2563921 actttattgc cggcctgtct tccggagcgg taaagggtta acattaaagg gggaagcaat 2563981 atgaaaaaga ttacatttat cggtgcaggg agcacgattt tcgccaaaaa tgttttggga 2564041 gactgcctgt taacagaggc actgaatgga tttgagttcg ctctttacga cattgatccc 2564101 aaacgcctgc aggaatccca gctcatgctc gaaaatctaa gagaccgtta taacccaagt 2564161 gtggccatca acagctatga tgacagaaaa ctcgccttgc aaaacgcagg ctatgtcatc 2564221 aatgcgattc aggttggagg atacaaaccg agcacagtca tcgatttcga gattcctaaa 2564281 cggtatgggc tgcgccagac gatcgccgat acagtaggca tcggcgggat attcagatct 2564341 ctcagaacaa tcccggtctt atttgatatc gcaaaagata tggaggaaat gtgccctgac 2564401 gcatggttct taaactatac aaatccaatg gccactctta caggcgccat gctccgctat 2564461 accaatatca aaacaatcgg gctctgccac agtgttcaag tgtgcacgaa ggatttattt 2564521 aaagctctcg gaatggagca tgacggaatt gaggaacgca ttgcgggcat taatcatatg 2564581 gcttggcttt tggaagtcaa aaaagacggc acagatttat atccagaaat caaaaggaga 2564641 gcgaaagaaa aacaaaaaac aaagcatcat gatatggtgc ggtttgaatt aatggataag 2564701 ttcggctatt atgtcacgga atcgtccgaa cataacgcag agtatcaccc gtactttatt 2564761 aaacggaatt accctgaact gatcagcgag ctgcaaatcc cgctcgacga atatccgaga 2564821 aggtgcgtca agcagattga aaattgggag aaaatgcggg atgatatcgt caataataaa 2564881 aaccttacgc acgaacgctc aaaggaatat ggttcaagaa ttatagaagc aatggaaaca 2564941 aacgaaccat tcaccttcgg aggaaacgtc ttgaatacag ggctgatcac caaccttcct 2565001 tcaaaagcgg ttgtggaagt gacatgcgtc gccgacagaa aaaaaattac accgtgcttc 2565061 gccggagaac tgcctgagca gcttgcagcc ttaaaccgga cgaatattaa tacacagctg 2565121 atgacaatcg aagcggctgt cacacgaaaa aaagaagcgg tttaccaagc tgcaatgctt 2565181 gatccgcata caagcgcgga gctttccatg aaggacatca tctccatgtg cgacgattta 2565241 tttgcagcac acggcgattg gcttccggaa tacaaataaa aactagggga ccgctctccc 2565301 ctagtttttt ggttttgttt cgccttccca ggccatcatg ccgccttcaa cattgactgt 2565361 tttaaagcct tgctcatcca ggtacttgca gacgttcatg ctgcgcattc ctgagcggca 2565421 gataaatacg tactctttgt ctttatcaag ggtttccatt ttttcaggaa tatcccccat 2565481 gcgaatatga acggcttgcg ggatcatgcc ttccgctacc tcttcatctt ctctgacatc 2565541 aattaaatat aattcttcgt ccgcctcaat tttttctttc aaagcggctg tgctgatttc 2565601 ttttatttcc aaagaaaaca ctcctattca cagtgatcat gttcagtata tcaaagtcag 2565661 ccgaacgatt gctattctga gactgatgaa aaaaaatccc cttttggcaa aggggatttt 2565721 ttctaggctt agtttgccac aatattgaca agcttcccag gcaccgcgat gattttccga 2565781 atcgttttgc cttcaagctg ctctttgacc ttttcatctg cttgagcaag ctgttccagc 2565841 tgttctttcg ttgcatcggc aggaacctgt aatttcgctt ttacttttcc gttcagctga 2565901 acaacgattt caacttcatc atccacaagt tttgtttcat catatacagg ccaagcttcg 2565961 taggcaattg tgccggaatg gccaagcttc tcccatagct cttccgctaa gtgtggcgcg 2566021 acaggagaaa gaagcttcac gaagccttcc atatattctt tcggcagttc tgttgcttta 2566081 taagcttcat taataaagac catcagctgg gaaatacccg tgttgaaacg aaggccttca 2566141 taatggtctg tgactttcat gaccgtttca tgatagacgc gctccaatgt ttcacccgcg 2566201 ccttcaacga tttttccatt aagctcaccg ctgtcttcaa taaataggcg ccatacacgg 2566261 tcaaggaaac ggcgcgcacc gtctaatcct gattcagacc aggcgattga agcatcaaga 2566321 ggtcccatga acatttcgta caatctcagc gtatcagcac cgtgagaggc cacgatttcg 2566381 tcaggattga caacgttccc tttagattta ctcatttttt cgttgttttc gccgagaatc 2566441 attccttggt tgtacagctt ttggaacggt tctttcgtcg gcactacgcc gatatcataa 2566501 aggaacttat gccagaagcg ggcatacaga aggtgaagca cggcatgttc tgcaccgccg 2566561 atatacatat cgaccggaag ccatttttcc aatttttctg gtgatgccag ctgatccgga 2566621 ttgtgcggat caatatagcg caagaaatac cagcagcttc ccgcccattg cggcattgta 2566681 ttcgtttctc ttcttccttt tttccctgtc tcagggtctg tgacttccac ccactcttta 2566741 atgttcgcaa gcggtgattc gcccgttccg ctcggtttga tttcatccgt ttttggcaaa 2566801 atcagcggca gctcctcttc cgggacagct gttgacgttc cgtcttccca atgaatgacc 2566861 ggaatcggct cgccccaata acgctggcgg ctgaagagcc agtcacgaag acggtacgtc 2566921 actttcttct caccgttttt cgtttcttcc agccaagcga tcactttttc aatcgcttcc 2566981 tgtttgtgaa ggccgttcag gaaatcagag ttcacgtgct cgccgtcgcc agtataggct 2567041 gcttcctcaa cgttcccgcc ttttacgact tccttcaccg gaaggccgaa tgttttggcg 2567101 aattcaaaat cacgctcatc gtgtcctgga actgccatga cagcacctgt tccgtatgat 2567161 gcaagaacat aatccgcaat ccaaatcggc agtttttctc cgtttacagg attgatcgca 2567221 tacgctcctg taaatacgcc tgtctttgtt ttcgcaagat ctgtgcgttc taggtcactc 2567281 tttgattgaa tttctttgat ataagcttca acagcttctt tttgctctgc cgttgtgatg 2567341 ttttccacca atgcgtgttc cggggcaagg acagtgtatg tagcgccaaa cagcgtatct 2567401 ggtcttgttg taaacactgt aaaggaatca tcatgtccat ctatagcaaa atgaacgtga 2567461 gcgccttccg aacggccgat ccagttgcgc tgcatatctt taatgctttc cggccaatca 2567521 agctcttcca agtcctcaag gagcctgtcc gcataagcgg tgattttcag catccactgc 2567581 ttcattgggc gtctctctac cggatggccg ccgcgttcgc tcttgccgtc aatgacttct 2567641 tcgttggcaa gaacagtacc gagcgcaggg caccagttta caggcacttc gtcaacgtaa 2567701 gcaaggcctt tttcgtatag ctttaagaaa atccattgcg tccatttata gtattcaggg 2567761 tcagtcgtat tgatttcgcg atcccagtca tatgagaagc caagcgcttg aatttggcgg 2567821 cggaagttat caatattctg cttcgtaaac acagcggggt cgttccctgt gtcaagcgcg 2567881 tactgttcag ctggcaggcc gaatgcgtcc cagcccattg gatgaaggac atcatagccc 2567941 tgcatgcgct tcatgcggga cagaatatcc gtagctgtgt atccttcagg atggccgacg 2568001 tgcaacccag ctccagacgg ataaggaaac atgtccagcg cgtaaaattt ttgtttttca 2568061 ttattatcaa gagtggcaaa tgttttgttt tcaagccaat atgtctgcca tttcttttct 2568121 atctctttgt gctgaaaact caaagtaaaa acctccttct gattgaatac ggcgtgtatg 2568181 gttcaagtat tgacgggaag gagaggatta tattcagaat attcccaaac taaaaaaaac 2568241 tccctcatcc caaaaaggga cgagagactt tcgttttccc gcggtaccac cctcgttagc 2568301 gcggcatacg ccgcactcac ttgatacttt taacgcagtt atgcgtcagc ggcttttcac 2568361 cgctgcaact ctgaggtgag ttcggaaaca aacttgattg actttcacca gccgtcaact 2568421 ctctgcaaca atatctgttt cttactgctc ctcttcattg ttcttatcgc aaccgtaatc 2568481 taactgtatt ttatagaatt ctgttcataa gtgcaagcag gtttgtatac aatgggaatg 2568541 taccctgaac gggcggagat tgaggacaat tattcgggtg gagttttggt ttgacgtttg 2568601 gactcggccg gttcgccgcc gctgttcagt tctctcacaa agtcaaaact tctgagaaca 2568661 gcttcaccgc cgtagcctga gataatggat aagatgacaa gttgaattcc tgaatcgggg 2568721 tcagcggata atacaagtaa aatggaagcc gtcatgccga taaaccaatc ttccaaaaat 2568781 ccaaggtaga taaaccgctt cgtcattctg ggcttctcca gcctgcctct ctttttcaca 2568841 tgaccgagaa tccccatgat tcctccaatt acacaagcaa tgagtacctg atgcagcatc 2568901 ttcatcatca ccttcctaaa gcccttattt cgtaaagcga cttcaggcca tccagccccc 2568961 ttaaacgatt ccgatgattt tcgatatcta cataccggca aatctgtaaa aagcttgttt 2569021 cttccattat atgtgaacac atgatcggta agcttgatgc attggattca tttttcaccc 2569081 agtgacattg acctagtcac ctatttagca tgtagaaaac ctttccgttc atatgttcaa 2569141 attctgttct tatttttagt gtatacgagg acaagcccta atgacaaaca acaaactgca 2569201 cttgcttgaa tcagaacatg tgttgtgcta cggttactgt agaattcatt tttaaaaagg 2569261 ggaatatcag gctttcgcat agcaagctga cggcctaagg gggatttata tggctagttt 2569321 tcaatcattt gggataccag gacagctgga agtcatcaaa aaagcacttg atcacgtgcg 2569381 agtcggtgtg gtaattacag atcccgcact tgaagataat cctattgtct acgtaaatca 2569441 aggctttgtt caaatgaccg gctacgagac cgaggaaatt ttaggaaaga actgtcgctt 2569501 cttacagggg aaacacacag atcctgcaga agtggacaac atcagaaccg ctttacaaaa 2569561 taaagaaccg gtcaccgttc agatccaaaa ctacaaaaaa gacggaacga tgttctggaa 2569621 tgaattaaat attgatccaa tggaaataga ggataaaacg tattttgtcg gaattcagaa 2569681 tgatatcacc aagcaaaaag aatatgaaaa gcttctcgag gattccctca cggaaattac 2569741 tgcactttca actcctattg tcccgattcg caatggcatt tcggctcttc cgctagtcgg 2569801 aaacctgaca gaggagcgat ttaattccat cgtttgcaca ttgacgaata tcttatcaac 2569861 atccaaagat gattatttga tcattgattt atccggattg gcccaagtga acgaacaaac 2569921 ggccgaccaa attttcaagc tgagccattt gctgaaattg accggaactg agttaatcat 2569981 tactggcatt aagcctgaat tggctatgaa aatgaataaa ctggatgcca atttttcgtc 2570041 gctgaaaaca tattcaaatg taaaggatgc cgttaaagtg cttccgatta tgtaaaaaga 2570101 tcccgctcac ccagctggat ctttcagatt gttgacaaaa tcctaaaatg gttttcattt 2570161 taggattttg tcatcttttc agcgtgattg aaaacccttg aagtctagga aggacgagca 2570221 taggagcgga gcgaatgttc taattcgtga gcaccgaagc gcaggcctga caacgaatgc 2570281 gagggtttgt cgacacgctg aaagatcccg ctcattcggc gggatctttt attatgaaga 2570341 gattgatgcc tgcttatttg tttctttagc tgattttatc cgtttgtcat atagaagcgt 2570401 tgtggcaata ctgatcagca gcaataccaa cagagataaa acaagagccc taatgccgta 2570461 atgatcgaca agcactcctc cgaacagggg accaatcatt ctgccgcctg tcgccgcact 2570521 gttgacaaag ccttgataaa agccttcttt ccctttaggg gcaagctgat tggcaatagt 2570581 cggcacagca ggccaaacaa gcatttctcc gatagtcagg atcaccatcg cagcgagaaa 2570641 catcggaaat tgctttgcag tcagcagcat gctgaaagac acaataaaaa tgataaagcc 2570701 gatgaccatt tgcgctttta gcgactcggc ccattttttc accacaaaac tgacgagcgg 2570761 ctggccgagc acaatgagaa ttccgttaac cgtccacagc acgctgtata aggaaagaga 2570821 tattccaatg ctttgtgtgt acgaagcaat tgtggttgac cactgagaat aagccagcca 2570881 tccgagtaca tagcctccgc ttaaaatgat cagtgcggca aattttgctt tgctgttcac 2570941 agcatcataa tcaagcacgg atgtttggga tgcatcgccc gtttgaatat ttcgaaatcc 2571001 gaaatataca ataaagaaaa agatcagata caatacggca tttgccaaaa atacatatga 2571061 aaacgagaaa gatgccacga caccgccaag cgctgaacca acggccacgc ccgcgttttg 2571121 cgcgacatat atcgcattaa atgccttcct tcccccttca ggccataccg atcccgccat 2571181 tgcgtagctt gccggaaaaa caacaccgga gccaaagccc acaatcgtca gcagcacaat 2571241 ataggctggc caatcatgaa aaaagacaag acccatcagg cttgctaacg taatggctat 2571301 cccaagcata atcgatttaa aaccgccgat tttatcaaac aaaaaacctc cgcataaatt 2571361 gccagccaca ctggcgccgg aattcagcat caggacaagt ccggctactg ttaacgactt 2571421 tcctaaatga ttatggatat aaatcgtatt cagcggccat aaaaaagaag cacccgtcac 2571481 attgataaac attccaatga ctaaaatttt aagagcacgc ggcatactca tccccctttc 2571541 ttacctaaaa aagctcatga aaaaaacgaa acctaaaacg gctccgtacg aatccagtta 2571601 tcatagcaca ttcattctat ctgtctctct cacatttttc aactgatgag cgtgaaaaaa 2571661 tctaacaaat attgtttgaa aaatgtaaaa taaatagaaa aaggggtcat attatggaaa 2571721 tggtattagc attcttaggt tttctggcat gtctcattgc actgggctat ggattatatc 2571781 accttgtcag atatgtactg aaaaaggaaa aacgtttctc aaagagactt ttttggccgc 2571841 ttttcattgg aggccttgtg ctgctcttta ccggggcagc attggcagaa cctgacactg 2571901 ccgcagcaaa tgccgagaaa aaatattcag cgctaaacgc cgaatataaa aacctcacaa 2571961 aagagcacga agaacttgag aaagaatata aatctgtcag ctctgaagca aagaaattaa 2572021 aagacaacaa agaagatcaa gacaagcttg agaagcttaa aaacgaaaat agcgatctaa 2572081 aaaagactca gaaatcatta aaagctgaga ttaaagagct tcaagaaaat caaaagcagc 2572141 tcaaagaaga tgcaaaaacg gcaaaggctg aaaatgaaac acttcgacaa gataaaacaa 2572201 agcttgaaaa tcaattaaaa gagacggaaa gccaaaccgc cagctctcat gaagacactg 2572261 gaagttcttc aaacaatacg agtaaaagtg atgaaaccaa aacagctgac aaagcagaag 2572321 gctgtaatat caaaggaagc agaaacggca tctaccacac gccaggcagt acatactacg 2572381 accggacaac cgatccggct gaaatgtttt gctcagttga agaagctgaa gccgccggtt 2572441 atcgggcgcc aaaacgataa acaaaaagct ccagaatgtc tggagctttt tctgtttcac 2572501 aacgacgatt taatgacctt cttataataa agaactgaca gaaaaccaaa aatggagtag 2572561 agcgcagtat ataacaccat caccataatc ataggcgccc atacctctga tccgaataag 2572621 aaccagccgg attggacggc aaagtaactg tggaagaggc cgacaacgag cggaatgccg 2572681 aagttgtaca tttgtttgat gcgtatcccc tttatcaggt cgccctgcgt aaagccgagt 2572741 tttcttaaaa ttgtatagct cggtttttca tcttcacttt cacccatttg tttaaaataa 2572801 aggatacaac ctgatgtaat caggaacgtt aaccctaaga agccgacgat gaacatcacc 2572861 ataccaaaca gtgatttttg cgcagcgctt gtatctagtc ttgataaatg ctcgtttttc 2572921 ttgttcacct gttgaaaaag ctcatttgct ttttccattt gatcgtcatg tttcacattg 2572981 acgccgataa atgtagattg cgccagctga atgcgggggt ctttatcctt gtccagctgt 2573041 ttaaacaggc tgtcatccac aatgacagcg ggcatgcccc cgcttgtaaa cgtgtaggac 2573101 acaagaaact cttctcttaa tcctttatat tttaatggct gcgtctcgtg cttgcttttt 2573161 actttaataa caccagagtc cttgaaaacc attatttttt gcagcaagtc ggtgtatcct 2573221 gagaaaacgg cttctccagc cgccacatcg actcctttta catctttgtc gctaacaaca 2573281 gcaagctgca tattgccggg atcgccctgc atctctttcg gagttccatc cataatattt 2573341 gcaatgtcaa catttgcttg caggacaggt gttgcctttt ttacaaacga gatgttgctt 2573401 tccctcaatt tgttttcaaa taacttggca tctttctcat tcatgaatga aaaatcagcc 2573461 gctacatttt gttcagcggt cttttccgac gagtaatacg agatgtaagc aagagataac 2573521 agcccgatgg cgagcgctga aacggttgta ataatcgtca gcagcagcgc attcgatttc 2573581 attctgaaca tgatcgaaga cagtgacaga acctcagaaa tatttaagta gccgcccttg 2573641 ctttttcgaa tgatattcga gataaacgta actgatcctt tataaaacaa aaacgtcccg 2573701 ataatgacgc tccccagaat gaagctcatc gcaacaaaca gttcattaat ggtcttaaat 2573761 tttccgccaa acagctcaga agacacatag tatcctgtca aaatcaacac gatgcctaaa 2573821 gcgccgatca gcatttggaa aaatgatatt ttcttcactt tgtcttcagt ggaggacgtt 2573881 actttaaaca aagataaaat actctgtttt ttgataaacg tataattcat gatcatgatc 2573941 aaaaggtaaa tgccgcagaa cacaatgacc gtttggacca aggcctgctc agaaaaatgc 2574001 agtttcgcat ccgctttgac atcgacaatt ttgaacagaa tcatcaagac aagcttcgat 2574061 atcgaaaacc cggccgctac cccgatcgct aatgaaccga aatacagcat gacattttct 2574121 gcacttaaga tgcgaaaaat tttatgcttc gtcattccaa ttaattgaaa cagcccgatt 2574181 tctttactcc gtctcttaat aaaaatcgta ttggcatata aaatgaagat cgccactaca 2574241 gccacaagca aaatcgaagc ggttttaata gccgcggctc ccttgattga agccttcact 2574301 tcgttaattg ctggatcata ctgcagcgtg acaaaggcga aataaagcgc cacgctaaag 2574361 atgagcgcaa acacatacaa atagtaattc cggagattct ttttcaaatt tcgcaggatg 2574421 agctgattaa tgttcatgct gcaccccgcc taacacgcct tgcgttttca taatatcctg 2574481 gaaaaacgtt tgcctgtcct ggcccccttt attcagctgt gtatacattt gcccgtcctt 2574541 aataaaaatg actctgccgc agtagctggc agcgacggga tcatgggtaa ccataataat 2574601 cgtcgcgttg cgtttttgat tgagctggct cagcttattt aatagatcgg aggccgattt 2574661 cgaatcgagc gcgccggtcg gttcatcagc gaaaataatg ctcgggtcat gaataaacgc 2574721 tcttccagcg gatgttctct gcttctggcc gccggaaatt tcattcgggt atttatcccg 2574781 caattcatat attcccagtt ccttggcaac ttcctcaaac ttgcgattgg cttccttttt 2574841 tgatagtttc gtgatcgata aaggcagaag gatattctct ttcactgtca atgtgtctaa 2574901 caaattgtaa tcctgaaaga taaagcctaa atgctgtttt ctaaattcag ccagctgctt 2574961 ttccttcata gccgtcatgt catttccatt aatatgaatg gttccgtgac tgacctgatc 2575021 gattgaggac agaacgttga gcaaagtggt ttttcccgac ccggaagcac ccataatact 2575081 gacgaattcg cccttttcaa tgtgaatatc gatgcccttc agcacttcct gtttattcag 2575141 cttgtttcca taactttttc gaattttatt cgcttctaaa atcaccattt acgcagtctc 2575201 ctttatattg gataatctca ttataaaaag gaatgccggg cttttccttc gatacggcga 2575261 acaaaaaaga aaagcatgtg acattttcgt cacacgctta tgacatgttc aaattgattc 2575321 cgtattggaa aggttaatgt aaaaactgtt cccgcaccaa actccgactc aacatcaata 2575381 tggatcaata acggcgccgc tgcttttttt gccaagtaca gccccatgcc agttgacgct 2575441 tgatcatggt gatccgttgt ggatgtaaac cctttatcaa aaatacgcgg tacatctttt 2575501 ggatcaatgc ccctgccaca atctttcact tggagctgcg tctgttcccc tttttgaaag 2575561 cttttgatct cgatttcaga ggcttcgctg tatttcaccg cgtttgtcag cagctgcctg 2575621 atgataaacg ccagccattt tgcatcgctc agcacttctt tggcctcgag ctgtatgtca 2575681 aaaccgatcc ctttttggat acaccacgat tgtaaatctt tgatttcttt aaagatcaaa 2575741 ggctgaagct gaatgaattc tactgacagg tcgttttcaa taaatgaaat gcgtttttga 2575801 tgaagctgct gatcaagaag caggtgaata cgcagccatt catatgacag ctgggatttc 2575861 agtgcttttt cttccattct atcaatgatt aaatgcatcg ctgttaatgg agttttgacc 2575921 tcatggatcc atgccatcag ctcatctttt tcattttcca atgctaagcg atgccgtgct 2575981 gcggtctgct tcaagtgttc tgtttgcccg gcaatgcttc tttcaaccat tgcttcaaac 2576041 ggcgtttccg gttcatttat ggctgtcaca tcgagattgt tctcccatgt tttcaagctt 2576101 ttataaaacg ctgtttcttt ccgatagcgg aaccaaagga atatgataaa aaacaagatg 2576161 cacaaataca ccatataaag tacattccca aatgatatgg aaggatcgac aaaagcaatg 2576221 aacagcatca aagcctgctg aaacaaaaac gcggcaatcc agctccgcct ttcgataagg 2576281 aatgctttaa tcatagaact tgtcctcttc cttcgcgatg tagccctggc ccacctttgt 2576341 ctcgatatat gcaccaagct gcagggcgtc cagttttttt cgcaggcgat tgacattgac 2576401 ggtcagcgta ttatcactaa caaaacgctc atcgttccac aagcttctga tcagctcttc 2576461 ccggctgacg atcttgtttt tttgctctat taattgtttt agaatgaaca tttcattttt 2576521 ggtcagttca acagatcctt tgtcattgct gacgaggttc tgctccgcgt ctacagcagc 2576581 gccgcaccac gttttaatcg tactcggctc cgtattataa tggtgcacac gccggaacat 2576641 cgcttggatt ttcgcgatca gcacatcaaa atgaaatggc ttttgaataa agtcatctgc 2576701 cccgagctgc atggacatca ccatatcagc aggatgatcc cgggaggata aaaagagaat 2576761 cggaacattt gaccgggagc ggatcagacg gcaccaatga aagccgtcaa atttaggcag 2576821 ctgcacatca ataatgacac aatcaggatt aaccgccgca aattcctgca gcacctgact 2576881 gaaatcctga atgccgtata catcatagga ccatcccgtt aaacgatcct tgatttcatg 2576941 aaacagcgat tcatcatctt caatcagcaa aagtttaaac aatcgactca ccgcactttt 2577001 tcctttttta tcaagtgtat agcaaaacgc cagcatgcgc tatagaaaaa gccggctgtc 2577061 tcagccggct cgttcgcatt ataattctct tctcaacgct gtcagcacgt tggttttggt 2577121 agcttttctc gccgggttca ttccggaaat gactgcgacc cctccgcaaa tcacaacggc 2577181 aatgatcaca aggctcgccg ggatgtagga gaatgtgtaa ttcaaatcgc ccgcatcgcc 2577241 accgcttgtg gccgcaagaa tcatcggaac ggccaggttg acaaggtagc tcacgccgta 2577301 agaaatgata atcccaatca cacagcctaa aattccgata tacgcgcttt ccatcaagaa 2577361 cattcggcga atgattgacg ggctcgcccc aatcgctttc ataatgccga tctcttgcgt 2577421 tctctctgtc accgccatcg tcatcgtgtt aaaaatgccg atcgctgaaa tgataactgc 2577481 gatacatccg acaaagatca gtccgatttt gaagaccatg aagaaggtat tggctccctc 2577541 aagttcagta gtcactgatg tgacatagta cccgtcatct gttagatcat ttgtcagctg 2577601 ttccacattc tcaaacttat cagcaaaaac accaatgttc gtttcaacat ttccgccttt 2577661 gaaatctaag aattccgaaa aatctttttt gaattgatca ctgataaaaa tatttgagtc 2577721 ctccatccag tcttgagatg gtttttttgt aataccgaca attttaaagt catatgtttt 2577781 tgtttttgta acatcccctg ttttagaatc tgtcttcgat acacttagtt caattgtttt 2577841 atttagaata tctttcgtat agccctttgg ttcttttata tcttctggat ttccttttgc 2577901 ttcctcgatt tttttgttat attcttccga ttcttttttc gttaataatc tctttgcgaa 2577961 gtcgtatcct actacgattt cattttccga ctttgcgact cttccctttt ccaattccat 2578021 attggccttt aattcatcat tcatattagt aaaaatgaga tttgagcttt catttgtacg 2578081 attgcctaaa gtagctttgt ttggttcata cacttgcgtt ctttctacaa ctgaccttac 2578141 gtgatcatac ttctctaaat cagctttttt aatcggcttg tctccttcct tgcccattac 2578201 gctgactttc gttacaatct gctggctcat tgtcatatct gtaatcgtct tttgaatccc 2578261 aaatccaacg gacgacaaca caaccaaaaa cgcacacgcc attgttgtcg ccagaatcgt 2578321 cataaagacg cgaagcctgt ttttcttcat atttcttctg ataaaatgaa cctgatcctt 2578381 aaacctcaac ggtaattcct ccttttagca caccatcatg aagctgaaat tttgaatgtc 2578441 cgatagaagc gacttcatca tcgtgagtaa tgatcacaaa tgtaatgcca cgctcacgat 2578501 tcagctgctg gatcaattcc agcacttcat gttccgtttc tgaatcaagg cttcccgtcg 2578561 gctcatccgc taagataatc gaaggattta aaatcaatgc tcgagcaata ctgacacgct 2578621 gctgctggcc gcctgacagt tcattcggat aatgagcggc gtggttttcc agaccgacgc 2578681 gtttcagcat gtcctgcacc ttttgcttcc gctcagatgg cttgattcct tttaacgcca 2578741 gcggcatttc cacattctca tacgtcgtta aacccgggat gagctgaaag ctctgaaaaa 2578801 taaacccgaa atggtcaagc cgaaattgcg cccattcctt ttcattaaac cccgtaacat 2578861 cagtgccatt aatgacaatc cgcccttttg tcggcgatat gtagccggaa attaaattca 2578921 aaagcgttga tttccctgag ccgcttcgtc cgacaatgca ggcgatttcc cctttcgcca 2578981 cgctcaatga aacatccttc aatactggaa cttcattctc acggcccttt tttccgatcg 2579041 tgaaagaatg gtcgatatgc tgaacatcaa tcatatgttc tctctccctt acaaaagttt 2579101 cattttttta taaatcgcaa aataactaat caagaaaccg attaccgcac ctgtacccat 2579161 gccaatgaga taaccggcaa agctctcgct tgcagtaaat ccaaaatagc cgaagcccat 2579221 gattcctatg ataataacga tgatctgcac cgggcggtta agcggcttcc ataagaagaa 2579281 atatccgttt ctttcattag acattttaac aaagctaata tagccgatga tgtaaaaaat 2579341 gatagtcatg atagccggaa tgactaaata atatggtgaa ttctcagccc atttcgagtc 2579401 tacataaatt atcggaatga aatactgcac ccatttaggt actggaccat ggataaaatc 2579461 tattgatccg ccaaaaagga tctcgaggtt gatcacaggc aggctgatga gtaaaaacgg 2579521 cgaaatggcc acggtaaatg agactagaag ctgtgcgaaa ctattgcctg tcaaagctcc 2579581 tccggccata accaaagaat aagccagcat gctaacaata atcattccca agctgtaatt 2579641 gtgaaaataa acggcctgat ctggcttcaa aagcatgatc agcaaaacag acaaaacata 2579701 acctatgagc tgcggcacca caatcaccat tccgccggta aggaacttcg catgaaatat 2579761 ctgccctcgt gtatatggaa ggcttaatgt aaaatcaaag aagctcttgc tacgttcaat 2579821 cccaagctgg ctgaccgcca aaacgactcc ccaaatccaa aacaatgaga taaatgagct 2579881 atttaaataa tcaacgctga atacgcaggg gccgacccaa ttttcttttc cagtgacaca 2579941 gccttgatag atgagataca tatttaaaat tgataatgga ttacctaata taaaaaccaa 2580001 aatggtgata actaaggcga ctttattctg ccgccactct ttgtaaagca gtccggaatc 2580061 cggcaactca cttccctcca aacctaaggc atttcttaca cttttgtttt cttataaata 2580121 gagaagtagc tcacaaagaa tccagccact gctccaatga tcatacccaa aatataacca 2580181 ataatggaat gtccggtata gtatccaaat aaaccaaatc caaggatgcc gaaagccata 2580241 accagaattt gcaccgggcg atctaatctg ttccataaga aaaagtgtcc gttccgttca 2580301 cttggaagct tcttgaagct tataaagcca atcaagtaaa atagcatgct cattacggct 2580361 ggaatcaata aaagatattt actgttaatc agccattcat ttacaacgta actaatcggt 2580421 actaggttcg ataaattgct tgccagagag aaataactct caggggaagg gaatatttcc 2580481 catatattcg caccaaaaac aacttctagg tttccaaccg gcaatgcaat aattaaatac 2580541 ggcaatatag ctgctgaaaa cgccgttaac agttgggcaa aagcatttcc agttaacgct 2580601 ccggcggcca tcaccagtga aaaagccata aaacttatca cgattactcc aatgctgctg 2580661 tgctcaaaaa agtagacgtg ttcagggtta tagacaagaa tcagcagcca tgcaagtaaa 2580721 aagccaatca attgtgacag cacaatcaca aaaccgccta accaaaattt tgtctgaaaa 2580781 atttggcttc tgttatacgg gaggcttaat ataaaatcca tcgtgccttt cgaacgctcc 2580841 attccgagga agcagaccgc caaaatgaca cccggcaccc agttgatatc tatcagattg 2580901 cttatggaat aattcacaat aaaatcacaa tattgcgggt cttggcgatc aagacaccct 2580961 tgataagaca aatacgtatt aacgatagaa agcggatttg ccaatactaa aaacgcgata 2581021 cttaacaaaa tcaccacttg attctgcttc cactctcgat agaggagacc tcggtctacc 2581081 atctccgctt ccctccaaac ttcgcaatga acacttcttc caggttgaca ggaagctcat 2581141 tccacacttt tggcttcagc tctctcaaaa agctcttttt ctcctcatcg cttttcggaa 2581201 tcagcactgt gtaaaacacg ccggcctgat cgagcatcgg aatgttttgc tctctgatgg 2581261 ccaaattgac atctgtatcg aaggccattt gaattttaat gtattcttct tttaactcat 2581321 caagatccat gacgttggtc aggctgttat cttcaagaaa accaattcgg ttgcacatcc 2581381 gctctatgtc ttcaagccgg tgggacgtaa tcaggatgct cgtatcacgc tctgccactt 2581441 catcgaccat cagctgcagc acatcatgcc ttgtcaccgc atcaatacca tccgtcggct 2581501 catcaaggag gatcagcgcc ggtctcgccg caaacgacag aacgagcgat agctgctttt 2581561 ttaagcctgt cgacagctca cggtattttt tcgtttccgg aatttcgtat ctgttcatca 2581621 gctcattcgc gtacgtgaca tcaaatttcg gatatattct tctcaaaata tcgactaact 2581681 gcttgtatgt atacttatcg taaaacggat tttgaacagg catgtagatg atattttgtt 2581741 tgactttcgg gtgctttttg atttctacgc cgtcaaataa aatcgttccg ctgtcagcga 2581801 aaatgatttg ctggattaag cgaagcatcg tcgttttgcc cgatccattg cgtccaagca 2581861 atccaaagat ttctcctttt tcgattgtta atgaaacatc ttttaatact tgattgccgt 2581921 caatcgcttt tgacagctgc cgcagttcaa tcattttttt tgcctccctt cacatcagcg 2581981 ctgatttcct ttatccattc gtgcagtttt tccagctcaa cccctgcata gtgtgcatcg 2582041 atgatgagct gtttgagttg ctctttaatc atcgtcatct tcccttcaac cagtgtcgtt 2582101 tttgcattct ccgatatata ggtccctctg ccccgcagcg tttcaataat cccctctcgc 2582161 tcaagttctt tatacgcttt gctgacagtg ttcggattcg caataatgat cgttgccaat 2582221 tctctgacag aaggaagctt atcaccaggc ttcatgatcc ctttcaaaca aagctctttc 2582281 atttgctgaa taatttgttc gtaaatgggt gttgagcttc ttggatcgat ttgaatcatt 2582341 tacttcccta ctttctatac gatctgaacc ttttatagat aaaaatgatc aattatactt 2582401 ttttgccatt caaaaccgat catcacaaga acaagaaaaa aagaacaagc gatcacagat 2582461 gccgcaatca gcattggcac gttacgtttg tttcgttttt tatgtttcat aactgcctcc 2582521 cttaatgtca atatataaat gattttatat tagtgtctat agtgtattac ttcaattagt 2582581 acacttaata caataaatac tttgactcac aaagtcaatc ctttttttac aaaaaaacgg 2582641 acccttttaa aagggtccgt tttcctacac atcaagaggg tgctgcagga tcatattatt 2582701 ttgcaaagat tgaagctgaa gtctcattct gtacagctgt tctctctgct gatcatttga 2582761 cgacagccat agtttattca aggcatttac cgcatcttct agctgcattt gtgcatcact 2582821 atattcttga tcgttataat gctcttgttt agaagcgatt ttcagctgtt cttcagcata 2582881 atcataggcc tgcatacatt gctggagatg ttcatctact gattgtcttg ttgccacagt 2582941 aacccctcct cttggtaatg gaaatcatcc atcattcata ttgtagcctc atctgacttt 2583001 attcaataaa gtaatttatg gtcgatattc atttgttctc ttgtgaaatg cgtgctacaa 2583061 ttttaggatg caatcgtacg caaggaggca catgaattgt gatgcagaac aatccttttc 2583121 cttattcaaa tacggaaaaa cgctatcata cattgaatta tcatctcaga gaacatttcg 2583181 gccataaggt gtttaaagta gcgcttgacg gcggttttga ctgtccaaat cgggatggca 2583241 ccgtagccca cggaggctgt acgttttgca gcgcagcagg ctccggagat tttgctggaa 2583301 accggaccga tgatttaatt acgcaattcc atgacatcaa aaaccgcatg cacgaaaaat 2583361 ggaaggacgg caagtacatc gcttattttc aggctttcac aaacactcac gccccggttg 2583421 aggtgcttcg tgagaaattc gaatccgtcc tcgccttaga tgatgtggtc ggcatttcga 2583481 tcgccacacg cccggactgt ctgcctgatg atgtcgttga ttacttggca gagctgaatg 2583541 aacgtacgta tttgtgggtg gagcttgggc ttcaaacagt tcatgaacgg actgcacttt 2583601 tgatcaaccg cgcacatgat tttaactgct atgtggaagg cgtcaataaa ttaagaaaac 2583661 acggcatacg tgtctgctcg catattatca acgggctgcc tttggaagac cgggacatga 2583721 tgatggaaac ggcaaaggcc gtcgcagatt tggatgtcca gggcattaaa atccatctgc 2583781 ttcacctact gaaaggcacg ccgatggtca aacaatatga aaagggcaag ctggaatttc 2583841 tttctcaaga tgattatgtg cagctcgtct gcgatcagct tgagatcatt ccgcctgaaa 2583901 tgatcgtcca ccgcattaca ggtgacggac cgattgagtt gatgatcggg ccaatgtgga 2583961 gcgtcaacaa atgggaagtg cttggcgcca ttaataaaga gctagaaaat cgaggcagct 2584021 atcaaggaaa gttctttcaa cggcttgagg aggaatcagc gctatgattt tgaagaaaat 2584081 tcttccttac agcaaagaac tgctgaaaat ggccgcggga gagggagata ttgtcgtaga 2584141 tgcgacaatg ggcaacggac atgatacaca gtttttagcg gagcttgtcg gtgaaaacgg 2584201 ccatgtatac gcattcgaca tccaagaatc agccgtggcc aatacaaagg aacggctcgg 2584261 tgacatgtat caagcgcgaa caacgttatt tcacaaaagc catgataaaa tcgctgaatc 2584321 cctcccgcct gaaacacatg gcaaagtggc ggccgcggta tttaacctcg gctatttgcc 2584381 gggcggggac aaatcaatta cgacaaacgg cagttctacg atcaaagcca ttgaacagct 2584441 tctcagcatc atgaaagacg aaggtctgat tgttctcgtc gtctatcatg gccacccgga 2584501 aggcaaagct gaaaaaaacg acgtgctcga gttttgccgg gacttggacc agcaaacagc 2584561 ccgtgtatta acatacgggt ttatcaatca gcaaaatgac ccgccattta ttgtcgccat 2584621 cgaaaaaaaa gctcagatca gcaaatgatt tgagcttttt tctttgaatt tttcatccag 2584681 gacatttttt gaaatttccg gtaggctctg ccgttgatat aaaagaaaag ggaggttttt 2584741 ccgctggctt tgatcagctt ctttgcgagc cggacctgct tcgtcttact ttaccatttt 2584801 tcaaattata tttgaaagca ataaccatcg ttaacccgga cgtcatacag ttcgggtttc 2584861 gatttttcca taaaacgttc acatatagca tgaaacgtat gacttttatc ttatcacaaa 2584921 actataaaca gcctctgcaa aaacacatac ctattctttc ctgttctcta ttttctatga 2584981 gcacacacaa aaagagccca ctgggagctc tttttgtcag ctgatatttc gttcgctggc 2585041 agcagccgca ttttttttat gaaacccttt tccatagtac acagccagca agatgagaaa 2585101 ccatatcggc ccgataatca cggctactct tgtatcaggg ctgtaagcca taagaatgac 2585161 gacgaatgct agaaatgcca atgacacata agacgtaaac ggaaataaag gcattttgta 2585221 ctttaattgt ttcttttctt ccggcttcaa acttttcctg tattttattt gagaaagcaa 2585281 aatgattgcc cacgtccaaa tcgctccgaa cgtcgcaata cttgtaaccc aagtaaatac 2585341 cttcgcaggg acaacatagt ttaacagcac tccgactaat aaagcgcccg ctgaagccag 2585401 aacagcttta cccgggatgc cgcctttcgt cagctgacca tatgcttgtg gcgcctcttt 2585461 ctgttccgcc aagttaaaca gcatccgccc tgtgctgaaa ataccactgt tgcatgaaga 2585521 cagcgcggct gtcaacacga caaagttaat gatacctgcg gccgatggaa tgcccacttt 2585581 ttgaaatgtg agaacaaatg gacttccttg agagccaatt tcctgccacg gataaataga 2585641 cataatgaca aataaagcgc ctacataaaa aatcaaaatc cgccaaaata ctgtatcgat 2585701 tgctttggct aacgattttt gcgggttttt tacttcgcca gccgtcaccc cgatcatttc 2585761 aatccctaaa taggcgaaca tgaccatttg aagagacaat aaaacccctt ttaatccatg 2585821 agggaaaaat cctccgttgt tccacaaatt gctgattccg gttgcaatgc ccccattgcc 2585881 gactcctgca ataatcatca ataaaccgac agcaatcatg gataagattg caacaatttt 2585941 aatcaatgcg aaccaaaatt ccagctcgcc gtaagctttg acagccagga aattaacacc 2586001 cgtcataatg accagtgccg ataacgccca aatccagttt ggcacgtccg gaaaccagaa 2586061 ccccatatag atgccgacag cagtgatttc ggccatacag gtgacaaccc ataaaaacca 2586121 gtagttccaa cctgttaaat agcctgcaag cggtcccaaa taatcacgcg catacctgct 2586181 gaaggagcct gcgaccggtt tttgaatggc catttcccca agcgctctca taataaaaaa 2586241 catgaccagg ccgcttgcgg catacgctac caaaatacca ggccctgcta attgaatagc 2586301 tgatgcggag ccgaggaaca accctactcc tatagcagct cctaaagaca ttaaagaaat 2586361 atgcctttct tcgagtccgc ggtgcagctc ttgtttttgt ttttgcatgc ttcttctccc 2586421 ctagaaaaaa atatcattat atcatttttc tgaatattcc gtacggattg ggtaaatcaa 2586481 tgatgatgga gaaataaaag gataacaaca aggctttcga ctactcgaaa gccttgttgt 2586541 ctgttacaca aagatgactt ctttaggctg atggctcagc tcttcaggca tataccgttt 2586601 ttcaatattg atgctgtgcc agatcataaa gattagcaca gtccaaattt tacggctgtt 2586661 atcagccttg tccgcacaat ggtcttcaag aagctgaagg acataatcct tatggatata 2586721 agcatccgtt tggctttctt gaataatatt ccgcacccat tcgttcattt cgtttttcag 2586781 ccaatgacgg atcggtacag ggaaaccaag ctttttgcgg tttaatacgt gctcaggcac 2586841 aattccttca gcggctttgc gaagaagata cttcgtcgtg ccgttcttcg ttttcagctc 2586901 atcaggaatt tttgaagcga cgtcgaatac gactttatcc aagaacggca cacgcagttc 2586961 caaagaattc gccatcgtca ttttatccgc ctttaacaaa atgtcgccgc gcatccaagt 2587021 gtggatatcg acatactgca ttttgttgat atcgctgtac gagctgcttt ctgtaaagta 2587081 agtcttcgtc acatcgcgat atgaaaggtt cggattataa tgcttcaaca gctgcttttt 2587141 gacagactct tcaaagattt tcgcgttacc gatataacga tcctgaagcg gagtgcagcc 2587201 gcgctcaagc aggctcttcc ctctcatacc ttcaggcata acggcagcaa cgtgcagaag 2587261 catctttttc aagccggacg gaatccgttc aaacggttta agcgaaagcg gttcacggta 2587321 aatgttatat ccgccgaaga gctcatccgc tccttcacct gataaagcaa ccgtaacatg 2587381 tttttttgct tcttttgcaa caaagtacaa cggaatcgct gccggatcag caagcgggtc 2587441 atcaaaatgc catacgatct tcggaagctc attcatgtat tcctcaggcg aaatgacttt 2587501 gctgatattt tcaatgccca gcgccgctgc cgtttctttc gctacatcaa cctcactgaa 2587561 gccctgctgt tcaaagccga cagagaatgt ttttaagctt ggatgaaatt ccttcgcaac 2587621 agacacaata aaggaagaat caatcccgcc agacaggaac gaaccgacag gaacgtcact 2587681 tctcatatga acgtttacag agtcatagat cgcgtctcgg acttctttca caagcttgtc 2587741 ttcttcagtc tgaaccggct tgaagttcgc tttgaaatac gttttgaatg tgatatcgcc 2587801 gtccgggcgg attgtgaatt gtgaacccgg ctctactttt ttcacatggg catcaagcgt 2587861 gcttggttca ggaacaaatt ggaaagacat gtactgctgc aatgcctctt tatctatttc 2587921 aatatcattc tgagcaacca ttaaactttt tctctctgag gcaaaataaa cctgatcatt 2587981 gatcgttgtg tagtacaacg gtttaatgcc gaatggatct cttgccccat aaagcacatg 2588041 atcgttttta ttccaaatca gaaaggcaaa cataccgcgc agtttggacg ccgcttcttc 2588101 tttatagtga cggtaagtcg caagaagaac ctctgtgtcc gaatccgtgt tgaatgtgta 2588161 cccctttgct tcaagttctt ctctcagttc gatatagtta tagatttctc cgttaaagat 2588221 aatccaatat gtttcatctt catatgataa aggctgtcca ccattttcta catcaataat 2588281 gctgagccgt ctgaatccga agccgacgtg ctcatcatgg aaatatccat cactgtcagg 2588341 accgcggtga acgatcattt ggttcatttg tttgattagt tcttcttgat cagcggtttg 2588401 agctaacgga tgcttgttaa aaaccccgac aaatccacac atagtattgc ctccataatt 2588461 aaaattgtca tcattgaacc cctatttata gacgctgtga atagtatttg gtttcacagt 2588521 tatgtaaaaa aataaacatg aatacaacga taaaaaaggg aaagccgctt aaccagtaag 2588581 cggctataaa attattctcc taacgcttct ttacgcagct gctccgcttt gtctgtgcgc 2588641 tcccatggaa ggtcaacatc gtgacgtcca aagtggccgt acgcagcagt ttgtttatag 2588701 atcggacggc gcaaatcaag cattttgata atgccggcag gtcgtaaatc aaagttattg 2588761 cgaacaactt caatcagttt ttcctcagaa gcttttcctg aaccgaatgt gttgattgag 2588821 attgacacag gctgtgcaac accgatcgcg taagcaagct gtacttcgca agaatcagca 2588881 agctcagccg caacgatgtt tttcgcaacg tatcttgccg cataagctgc agaacggtct 2588941 accttcgtcg cgtccttacc tgagaacgcg cctccgccgt ggcgtgcata gccgccgtac 2589001 gtatcaacga tgattttgcg tcctgtaagt cccgcatccc cttgagggcc tccgattacg 2589061 aaacgtcctg tagggttgat gaaatatttt gtttcttcat caatcagctc ttcaggaaca 2589121 accggattga ttacatgttc tttaatgttg cgctgaattt gctcaagtgt aatttcaggg 2589181 tgatgctgag ttgaaataac aatcgcgtca atgcggactg gtttgttatt ttcatcgtac 2589241 tcaaccgtta cctgtgtttt gccgtcaggg cgaaggtacg gaagaatatc ttctttacgg 2589301 acttcactta ggcggcgggc taatttatgg gcaagtgaaa ttggaagagg cataagctct 2589361 ttcgtttcgt tgcacgcata accgaacatt aatccttggt cacccgcacc aatcgcttca 2589421 atttcttcgt cgctcattgt gccttcacgg gcttcaagcg cttggtctac gcccatcgcg 2589481 atatcagcag actgctcatc aattgatgtt aaaaccgcac aagtttccgc atcaaatccg 2589541 tattttgcac gtgtgtatcc gatttcttta atggtttggc gaaccgtttt cggaatgtca 2589601 acatacgtag aagttgtgat ctctccgctt acaagaacca aacctgttgt cacagatgtt 2589661 tcacaagcaa cacgcgcgtt agggtctttc tttaaaattt catctaaaat gctgtcagaa 2589721 atctggtcac agattttatc cggatgcccc tccgtaacag attctgatgt aaataaacga 2589781 cgatttttac tcatgatttg cttcctcctg cacaaggcct cccgaaagac cttgtatata 2589841 tgatacggaa ctcgctccct cttatacaat gtacagttat attagagaat gttaattggc 2589901 atatttatga aataaaaaaa ccttttccat cgaggaaagg gtttggtctt tgtgcctttc 2589961 actcttatcg ctcaaggaat catacaacct tgcaacaggt tagcaccttg gttgtctcac 2590021 tcagttgaac ataataaata acagagaaac cggttgctgg gcttcatagg gcctgtccct 2590081 ccgccagctc gggataagag tatccgctca atgaaatatc ttatcgtaaa agggtttgca 2590141 atgtcaatat gattcagaag aaataggcac ctatattgag ggaaaacaat ggaaatgcac 2590201 acacaaaaaa caataaatag tatagactat ttgaaaatat atgttatact aattcacaat 2590261 tagcaaaaca caaaaaacga taaaggaagg tttcatatga actcagttga tttgaccgct 2590321 gatttacaag ccttattaac atgtccaaat gtgcgtcata atttatcagc agcacagcta 2590381 acagaaaaag tcctctcccg aaacgaaggc attttaacat ccacaggtgc tgttcgcgcg 2590441 acaacaggcg cttacacagg acgctcacct aaagataaat tcatcgtgga ggaagaaagc 2590501 acgaaaaata agatcgattg gggcccggtg aatcagccga tttcagaaga agcgtttgag 2590561 cggctgtaca cgaaagttgt cagctattta aaggagcgag atgaactgtt tgttttcgaa 2590621 ggatttgccg gagcagacga gaaatacagg ctgccgatca ctgtcgtaaa tgagttcgca 2590681 tggcacaatt tatttgcgcg gcagctgttt atccgtccgg aaggaaatga taagaaaaca 2590741 gttgagcagc cgttcaccat tctttctgct ccgcatttca aagcggatcc aaaaacagac 2590801 ggcactcatt ccgaaacgtt tattattgtc tctttcgaaa agcggacaat tttaatcggc 2590861 ggaactgagt atgccggtga aatgaagaag tccattttct ccattatgaa tttcctgctg 2590921 cctgaaagag atattttatc tatgcactgc tccgccaatg tcggtgaaaa aggcgatgtc 2590981 gcccttttct tcggactgtc aggaacagga aagaccaccc tgtcggcaga tgctgaccgc 2591041 aagctgatcg gtgacgatga acatggctgg tctgatacag gcgtctttaa tattgaaggc 2591101 ggatgctacg ctaagtgtat tcatttaagc gaggaaaagg agccgcaaat ctttaacgcg 2591161 atccgcttcg ggtctgttct cgaaaatgtc gttgtggatg aagatacacg cgaagccaat 2591221 tatgatgatt ccttctatac tgaaaacacg cgggcagctt acccgattca tatgattaat 2591281 aacatcgtga ctccaagcat ggccggccat ccgtcagcca ttgtattttt gacggctgat 2591341 gccttcggag tcctgccgcc gatcagcaaa ctaacgaagg agcaggcgat gtaccatttt 2591401 ttgagcggtt acacgagtaa gcttgccgga accgaacgtg gtgtcacgtc tcctgaaacg 2591461 acgttttcta catgcttcgg ctcaccgttc ctgccgcttc ctgctcacgt ctatgctgaa 2591521 atgctcggca aaaagatcga tgaacacggc gcagacgttt tcttagtcaa taccggatgg 2591581 accgggggcg gctacggcac aggcgaacga atgaagcttt cttacactag agcaatggtc 2591641 aaagcagcga ttgaaggcaa attagaggat gctgaaatga taactgacga tattttcggc 2591701 ctgcacattc cggcccatgt tcctggcgtt cctgatcata tccttcagcc tgaaaacacg 2591761 tggaccaaca aggaagaata caaagaaaaa gcagtctacc ttgcaaatga attcaaagag 2591821 aactttaaaa agttcgcaca taccgatgcc atcgcccagg caggcggccc tctcgtataa 2591881 aaaacaaaag ccaagagcaa ttatgctctt ggcttgtttt aattgacgga atgcaaagaa 2591941 gtcagcttgt atgtaatgat ggtccggcct tcttcccatt gaagcttctg cacttcagct 2592001 gtgcctgact tttcgccaaa ctttgttttg cgtacatcca ttggaatctc catcggatat 2592061 actcggtatc cgtccttctc taacgtgaat atattttcat ctatgcgaac ttcttttcct 2592121 tttgtcacaa tcagtgtatt aaattcaaca ggcattccca aagtgaaatc ccctttcgtt 2592181 ctcttttttc tttatcataa catatttcac tgtcagcggt ttttcatcca ttgtgtgagc 2592241 tgccgcacga tacgccggtt ttcttttggc gggaaataat gtgtgaatgt actgtagtac 2592301 catgtttcca ccggcttatg cagttgtttt agcttctctt ctaataaata ggaatgctga 2592361 atcgaaacat tttggtcttt ttctccatgg attaacagca cgggagcctg aattttgttt 2592421 acttggtcaa acggtgtcct ccattgatat tcctcaggca cctttttcgg tgttccgccg 2592481 atgactcttt tcatcattcg ccgcaaatcc tgccgctcct cgtatgtaag aatcatatca 2592541 ctgacgcctc cccaggaaac aaatgaagct gcctgcccgc ccatttcgat cgcagtgagc 2592601 attcccataa ttccgccgcg ggaaaaaccg aagatatgga ttctatcctt cttgacattt 2592661 gggtgctgct gaagcaggcg aaaagcagaa aatgcatcct ccctgtcttc tccggcaaaa 2592721 tcctcattgc cttctcctcc ttgattgcct ctgtaaaaag gagcaaacac cacaaaccct 2592781 tgggatgcaa actggataat ccggcccggc cgaaccatgc ccacgctttt aatcccgccg 2592841 cgcaaatata aaaatccgtc atattgtccc ggttccgccg gctcagccag aagcccctta 2592901 acccgtaatc catttgacag atagcagatc gtatacaaac gcacatgctg gcttggcgac 2592961 ggaaatcttc ttttctctac aatcaaaaca gccgcctcct tttttctata tgctttcctt 2593021 actccaaaat tacatccgga gaacctggtt aggcattcac acatttttat acccatcata 2593081 cgatatgtaa agcaaaaaag gatattaact tgatgcgaaa taaggaggtt gtctatgtga 2593141 acagatggtt aaggctgggc ttcgcctgtg tcggcagtat ctttctgatg ttcgccctgg 2593201 cggcttgcaa gcaggaagaa acgctcacca aagtcaaagt agctgaagtg acccattcaa 2593261 ttttttacgc acctttatat gttgctgagt ctaaaggttt ttttaaggaa gaagggcttg 2593321 atgtcgatgt gaatacgacc tggggcggag ataaaacgat gacatcgctt ctttccaacg 2593381 gctccgacat cgcgcttgtc gggtcagaaa catctattta tgtcgaagcg caaggggcta 2593441 aagatcccgt cattaatttc gcccagctga ctcagacaga cggaacgttt cttgtcgcga 2593501 gagaagatgt tgaacacttc gactgggatc agctgaaagg aaaaacgttt ctcggtcagc 2593561 gaaaaggcgg catgccgcaa atggtcggcg agtatgtact gaacaaacat aagattgacc 2593621 cgcataagga tatagacctc atccagaaca tagacttcgc caatattgcc aatgcgtttg 2593681 cttctggaac cggtgagtat gtacagctct ttgaaccgca ggcttctctc tttgagaaaa 2593741 aaggcatcgg ccatatcgtg gcttcattcg gagaagaatc aggagaggtt ccttatacga 2593801 cttttatggc gaaacaaagc tatttgaaga aaaatgaaga cacagccgtc aagtttacaa 2593861 aagccattta taaggcgcag cagtgggttg aaaatcattc tgcgaaggac atcacagatg 2593921 ccattaaaga tgaatttgat gataccgacc cagacgtcat cgaaacatcc attgaacgct 2593981 ataaaaaaca gcattcatat tcaccagacc ctctgcttaa cgaaaaagaa tgggagcttc 2594041 tccaaaccat tatggataaa tcgggagaac tgccgaagca cattccatac aatcagcttg 2594101 taaataaaga aattgctgaa aaagtcacct cggagaaata ggaggcgcca tctatgtctt 2594161 tcttacatgt cgaccatgta acccatactt atttttctat taaagaaaaa acaacggctg 2594221 tgcgggatat tcatttcgat gccgaaaaag gcgatttcat ctcatttctc ggcccaagcg 2594281 gctgcggaaa aacaacattg ctttccatta ttgccggttt gattgagcca tcagaaggca 2594341 gagttctgat tgaaggccgt gagccgaatc aaaaagaaca taatattggc tatatgcttc 2594401 agcaggatta cttatttccc tggaaatcta tcgaggaaaa tgtgcttctc ggtttaaaaa 2594461 tcgccgacac gctgacagaa gaaagcaaag ccgctgcact cggtctattg ccggagttcg 2594521 gcctcataga tgtggagaaa aaatatccga aagaactgtc aggcgggatg cgccagcggg 2594581 ctgcgcttgc aagaacactt gcgcctaacc ctagtctgct tttgctggat gagccatttt 2594641 ccgcgcttga ttttcagaca aagctgtctt tggaaaacct ggtattccgc acattaaagg 2594701 aatatcaaaa aacagcagtg cttgtcactc atgatatagg ggaagcgata gcgatgagcg 2594761 atacgatctt tttattttca aatcagccgg gcaccatcca tcagattttt accattccta 2594821 aggaattggc cgcgatgttg ccttttgacg cccgtcagga accttccttc cagacactgt 2594881 ttcaaacgat atggaaggag ctgaattctc ttgagaaaca gcaaagaaac cattgatctg 2594941 cttcacgagc agtatcaatt caaacagaaa aaggaaaagt ggaaggtcca ttcctttcag 2595001 cttgccatat ttattctctt tttctcgggc tgggaaatct ccagcaggca gggctggatc 2595061 gatccgctga tcttcagctc tccatcagct gtgtggcgat tattgctgga gaaacttggt 2595121 gacggttctt tactgtcaca catcggcgtc actttatttg aaacggtgct tggctttttg 2595181 ctcgggacgt ttatgggcac gtgcctagcc gctttgttat ggtggtctaa ccgacttgcc 2595241 agaattttag atccgtatct tgtgattttg aacgcaatgc cgaaagtggc cctgggcccg 2595301 atcctgattg tcgcgctcgg tcccagtttt atcagcatca ttgcgatggg agccatcatc 2595361 agcgtcatta tcacaaccat cgttgtctac accgccttcc aagaggtcga cgaaaactat 2595421 acgaaagtca tgaaaacatt cggcgcaaaa aagtgggtta tttttaaaga agtcatactg 2595481 cctgcatcct cccccgcgat tatttcaaca ctaaaagtga acgtcggttt atcatgggtt 2595541 ggcgttattg taggggaatt cctcgtttcg aaggtcggat taggatatat gattatttac 2595601 ggattccaag tcttcaattt tacactcgtc ttcttaagcc tgctgatcat cgccatcttc 2595661 gccactctga tgtatcaggg cgtcgagctg ctggaaaaga aatggacgaa ggggaggaca 2595721 taaaaaaccc ggcacatgtg ccgggttttt tattcaatcc atccagattc tttcagtttt 2595781 ttcaagctga tcggaagaac ggaatccttc ataataaagc tgaatttttt attgcgggaa 2595841 aggttctccg gcagctcgtg aaacaaaacc gggcctttcg tttcaaagta atcagcctgc 2595901 ttttcaagct tttctatatc tgcaaaatat atatttttta caatcacttt ttcttttccg 2595961 agaactttat actgtccgag atacttgagg cttttgactc tcgcgcccgt ctcttccttt 2596021 acttcccgga gcgcagcctc ttctgcgcac tccatcggct ctactttccc gcctggaaac 2596081 tcatagcctc tgtcctcatg ttctgttaaa agccatttgc cgccaaaacg gcaaatcacc 2596141 cagacatgct tcgggctgtc cgagaaaggc tgatcgtcaa aggaaagctg aacagtattc 2596201 tgataataat ctttaaactc gtacatgttt atccctcaaa tccgttccta gctatcttcc 2596261 atacatcata ccacagttac gtttcttcgg aagcctttta tcaaaaaata agggaaaccc 2596321 agcacgccgt caggttctgc atgcagacta gctcgtacag tttttttgcg atacttttgc 2596381 cggaaagtgc gaccgacgct ctgggcttta ttatgacccg cgaacaggga aaagttacgg 2596441 tttgcgctta aatttatttt ttaacgtttc taaaagatcg acaagcatct gaggaaccgg 2596501 tatgccaaga gagctggctg tcacaacaat ttgcacagat tcataaagaa tataaaacat 2596561 aatagccaag tcacgaattg atccctgtgt attcagcagc tgatcaaaaa agtggcatac 2596621 agagatcaga gccagcgtga ctaatttttt gacaagccgg gcaaatacct ttttaaatga 2596681 cagtttgtga ataatggttt ccttcaaagt cgtactgata aattcaattg ccataagaga 2596741 gagcaaaatc agaaatgaat actgaaaacc tccaaagaaa aaacccgctg ctgaaacgct 2596801 gactgctaaa aacgaaaaga tgccaaagtc tctatccatt tatcccaaca tcctttcaca 2596861 gaaacggcct tacgatattc tatggtaaac aagccgaacg gattggattt ttcagaaaaa 2596921 tggactggtt gtcgcctatt tttcagatac aaaaagaaaa gccggacgtc ttttttaaga 2596981 catccggccg ttctattttt gaacttaacc taggtaagct tttagcatcc agttatgttt 2597041 ttcaatattt tgatggatcg caagaagcat gtcccctgtt gtttcgtcac cgacttcatc 2597101 agctaaatcc atgccgtttt tcagctcttc cgcgatgact gtgaaatcat catatacgct 2597161 ttgaaccatt tgttcagctg tttcatttcc agcagcttct ttgacagaag ccgtttctaa 2597221 ggattccttc attgttgcaa tcggttttcc gttcagcgcc aaaagacgtt ctgctaagtc 2597281 atcaatataa gttgctgttt cgttgtacag ctcctcaaac ttttcatgaa gagtgaagaa 2597341 atctttccct ttcacatacc agtgataatt atgtagtttc acatacatga ccgtccagtt 2597401 ggctacttgt ttgttcactg cttgaatcaa ttgttctgac atggtatctc ctccttgtta 2597461 tatgactatg tataccctta atatcgtacg ctaaaacctc ttttttaccc ttatctgtca 2597521 cgatttcttc tattatgcta caattgttaa aaaacgggag gtggaatgtc atgacgcttc 2597581 tcattacgat aagtattttg attgtgctgg ctgttttgct tgtaaccatt tggacgactg 2597641 taaaagccta taatgtaaag cataccattg atccaccaca agaaaatcac tctgattcac 2597701 acaatcaatg atgatgtgaa tgctcctctt ctgactgatt gctggcagca tcggcgtctc 2597761 cgacttggac ttttaaggtc ggcatgctat gctgtttttt tgctgtgaca tgagattgga 2597821 cagtgtatac accatcttcc ttaaacgtcg tttccaatcg gtatacgcct ttttcttgtt 2597881 tcaccttaaa catttggctt gcgtcttttt ccccttcttt ccatacttca aactctactt 2597941 catcggcatc cgtcacagct tcatcaccat atgatacagc tgcttcataa gcagcgcttt 2598001 ctccgggatt tactttttca ggcccggtca gcttgacatc caaaacctcg ggcgtctcag 2598061 ctgtatttgc tttactttca ccagatccgc atccattaag caataaagca gaaaaaagca 2598121 gaacaaccaa catctttttc atgccatcac cctttcatcg tttacctaaa tagtagcaaa 2598181 cgcttacagc aaatggtaca caaaatatga gacgtcacaa aaaagacctt tttgcttaag 2598241 cgcaaaaagg tcctttctat tttagccaaa tacttttagc aattcttctt tatcctgtga 2598301 aagccagaaa cgcattaaac gtttagcgcc ttccagatca tgaagcttcg cttggccgca 2598361 ctgcttttca ttcgcagcag gtatttctgt aatctctacc gcttccttca ttgtgtcttc 2598421 aagcagatca acgatttccg ctgatgtcgg ctctccgctc acaactagat aatagcctgt 2598481 ctggcagccc attggagaaa tatcaatgat atcaaaatga tcgtatttct cagcgtgaga 2598541 acgaatcgta aacgcgagca aatgctcgag tgtgtgaatg gtgtcaggct tcatcgcctg 2598601 tttatttggc tggcaaaaac gaatgtcaaa tttatttaca acgccgtctg ttcccacttt 2598661 atgcacgccg caatgtctta catatggagc aacaaccgca ttatgatcaa gctcaaaact 2598721 ttctactgaa ggcataatgg cactctcccc ttttttaaaa atgtaatttc attataacat 2598781 acttttccga taagaattat tgattaactt ttcaatctgt gttttttttc ttatacttgc 2598841 atcagaaagg ttgctgaaga aacatgaaaa ccctattcat cgctctgatc agaggatatc 2598901 aaaaattcat ctcgcccctg acaccgccaa cgtgccgctt ttatccgacc tgttcccaat 2598961 atggaatcga agcgattaaa acacatggcg ctttaaaagg cggatggctg acaatcaaac 2599021 ggattttgaa atgccacccg ttccatccgg gaggagtcga tcccgttcct gaaaagaaac 2599081 aaaaacatta attgttataa ccgtttacga taagatccag ttttccggtt ttaggatcaa 2599141 tgactaagcc atggaccgga acgttttcag ggaacagcgg gtgatgttta ataacatcta 2599201 cgctgtcttt cacactcgct tccactgaat caaagctttt aaaccattga tcaaagtcta 2599261 caccggagta ctttattgtt tcgatgcgtt cttccggaat ccctcttgct ttgatttttt 2599321 caagcatgct tttgctgctg attttgctca tgccgcaatc gtgatgcccg atcacacaca 2599381 cctcatctgc attcagctcg tacactgcga cgagtatact tctcatgatg cttccgaatg 2599441 ggtgtgtcac aagcgcaccg gcacttttaa tgattttcac atcaccgttt cgcaaattca 2599501 tcgcatgcgg cagcagttca accagacgag tatccatgca agaaagaatc gccatttttt 2599561 tatctggaaa ttttgatgtt tgatactttt catactctct ttgttcagta aatgtcttgt 2599621 taaattcgag aatatcattt agaagactca tgttcgttgt ccctttctat tctttttact 2599681 cttcaatata tcacaaccct tgtttattcg tcataataaa aaaagacaaa ccctcaggcc 2599741 tgccttattt ccccatgtta tagcgttttt tgaactgctc aactcgtccg cctttttcat 2599801 tgaatttctg gcggcctgta taaaacggat gcgtgtcaga gcttacctct actttaatga 2599861 caggatatgt gtttccgtcc tcccactctg ctgtttcatt agatgttttc gtagaggtgc 2599921 ttagaaaacg gtagccgctg ttgacatcct gaaatatcac tttgtggttc tttggatgaa 2599981 ttccttcttt catgggtatc tcctttcaat aaatcgtaat aattacgttt tattttataa 2600041 ccttacaaac gttttgtcaa tcttcttata tccttccctc tgtttcacat cgtaaacctc 2600101 atggcattta agaataggaa gaataatcta accgaggaag caaataataa acccaaaata 2600161 catacagaac gtctttttgg aaaggtggtt tacgattgtg gatgatttag ttttggccag 2600221 aagccttttt ggcacgacga tgggctttca tatcattttc gcaacacttg gagtcggtct 2600281 gccgctcatg attttagtgg cggaattgat ctatcaaaaa acgaaagatg accattatgc 2600341 gatcatggcg aaaagatgga cgaaagcaca agccgttttg ctgggggtcg ccataccgac 2600401 cggaacgatc gcgggcactc agctcgcgct tttatggccg ggatttatgg aagtcatcgg 2600461 ccgggtgatg tccctgccat ttcaaattga aatctatgct ttttttgttg aagccctatt 2600521 catgtcgatt tatgtatacg ctgcagaccg tttgtcacct gcaatgagga ttgttgctgt 2600581 tttctttgtg ttagtcgggg cagcagcatc cgctgttctg atcacgaatg ttcacgcttt 2600641 tgaaggtacg cccgccggtt ttaaaatttt aaacggaaaa attacagatg ttgacccgtg 2600701 ggctgcgttt tttaatccta gcttttttat cactgccggc catgtcgtgc tgtccgcgtt 2600761 tatgactggt gcgtttatcg tggcttctgt tgcggcgtat aaaatgatcc gaacgaggaa 2600821 aaaggaaagg gtctatcgct ttcaccggaa agcccttttg ctcgcactga cgatcggcgg 2600881 tattttttca ttgctgaccg ctttgaacgg acacgaatct gcacagatgc tgtacgaata 2600941 ccagcccgaa aaattagccg gtgcggaagg cctatttgaa acaagatccc acgccccgct 2601001 cgctatcggc ggttttaccg acccgaatga agaaaaagta aaatgggcaa tcgagattcc 2601061 atgggcttta agctttttgg cagcgaaccg ttttgacact gttgtaaaag gattaaatgc 2601121 atttccgaga gatgaatggc cgccgctttt cattcacacg ctgtttaatg cgatggttgg 2601181 tgtaggcatg ctgctaattc tttattccat tatcggtgtg gtctggagaa aggtgctcaa 2601241 gaaagaccgt ttcccaacgt ggcttttgat cattttcatg acagcaggcc cttttagtct 2601301 catcggcatt gaattcggct ggattttcgc atgtacgggg aggcagcctt gggtcatcta 2601361 tcatctgctg aaaacgtcag atgtcgtaac aacgactggc tcgatcgggg tgctgttctt 2601421 atttttcaca tttgtttatg ccgtgttagg cgcagctgtc gtctacgtgc tgctgtatta 2601481 tttccgcaag cacccggttg acgaagattt aaatacagcg gagtcgtaat ggctccgcaa 2601541 acaggaaacc aaatggaagg aagatcgtac aaatggagat ttcaactgac gctctgatcg 2601601 ccatctcaat tatctggggc tttgtgttta tttacgccgt catggcgaca atggattttg 2601661 gagcgggatt ttggtctatg atctatttaa acaaggagca tatgaaggcc accgatattg 2601721 cgaatcgctt tttgtccccg acttgggagg tcacaaacgt ctttattgtg gccatcgtcg 2601781 tggcgctttt cagttttttc cccggcgcga catttgtgct cggcaccgtt ttattaattc 2601841 ccggaagcat gattttgctg cttttagcaa ttcgaagcgg atttctcgtg ttttcaaata 2601901 cagcaaagga gcggaaaacg ctaagatata tttccggcat ctccggcttt atcattcctg 2601961 ctattttaat tttggtgctt cctgtgacac acggagggtt tatagaaaaa acggatggaa 2602021 tctataactt aaatatgtct aaaatctttt caagccccaa cgcctattca tttatcgggt 2602081 ttgcgatttt aagcacctta tttttgtcct cgctgttgct tgcagatttt tcaaatgtgg 2602141 cagaggaaca ggatgcgtac cgagcctaca gaaaaagcgc cctgattacc ggcccgattt 2602201 cactgttgtt tgctgtatgc attatggtaa ctatgcggaa tgaagcaaac tggctgtaca 2602261 gcggaatgat gaatgatttt tcttggatta ttgcatcgtt cattacattt gtcattgctg 2602321 gaatcgctct ttttctgcct aacaaaagct ttggtcaaaa catcggaaaa ccgcgtctcg 2602381 cacttgttgc gattgggata cagtattttc tcgcaagcta cgcgtacggg cgggcgcatc 2602441 ttccgtatat gatttatccc gatgtgacag tcatgtcagg cttcacagag ccagcaacgt 2602501 tcagagcgct gtttgcaacg tatatcgttg catttatcat tctatttccg ggcttctttt 2602561 tcttctggaa aatgtttatg cgagataaac gctatatccg ccaggaggaa tagagggcaa 2602621 gccagccggc tatactaatc cagaaccttt ataaggaggg gatggcatgg agcagaaaat 2602681 tctatgtgag gtcaacaact gttcttattg gggcaaaggt aacaaatgca ccgctgatgc 2602741 catttatgtt gtcagccata ctggtgaaac ggctgaaaac agccgggaaa cagactgcaa 2602801 aacgtttaag ccgcatgatt tataattaaa agaaagagct gcatcagcca gctctttctt 2602861 tttgcatgtt gagtgttctc agctttttag ttatgacccc gtttgcaggt gaaaacaaaa 2602921 aggcgcttgc ataacataca cctgtcatgg ccgccatcgc tcctgaaatc gaaacattaa 2602981 gccacgttgc gaagaaatag cccatgaccg ccgacagccc gccaatcaac gcgctgagaa 2603041 tcagcatata aagaagccgg tctgtcagca aatgtgccgc agccggcgga acaatcagca 2603101 tggccacaac caatacggca cccaccgaat caaaggaagc aacagtcgtc aaggacagca 2603161 tgcccatttg cacgtaatga atgagcaaaa ccggtattcc caaggctaaa gccatttgag 2603221 gatcaaacga agcgatttta aactccttat agcacacact gatcaacact acgtttaaaa 2603281 ccagaacaga tgccagcatc caaaacgctt tcggcccaat atcaaccccg aataccgtca 2603341 ccgtattcca cggcacaaaa gcgatttctc ccattaacga gtgctcaata tcgagatgga 2603401 cattcgctcc atacacagaa agcaaaataa ccccgattgc aaataaggat gtaaacacaa 2603461 ctcctatggc agcatctgat tgaaccccct tgctatgaag aagctgaacc aagaaagccg 2603521 ttaacagacc ggttgcggct gcgccaataa acatataaat cccatcgaga cttcccgtca 2603581 ctagaaaagc gccgacaatg ccaagcaaca ctgtgtgact gattgcgtcg gccagcatcg 2603641 ccatgcttct cagcacaaga aatgtgccga tcaatccgca gcttacaccg actaatacac 2603701 cggtagctat aatccatgct tcaaaactca tttgcgatct gtcccttctc ggcatcatga 2603761 gacgcttttc gacgctcagg catccgtcca tacagcttta agagtgaata aagccgctct 2603821 ctcgtttctc tcggtaaacg gtccgggtca aagtagtcct gatcggattc tatattggca 2603881 agttccattt catgcatgag atacacttca tacatccgct gcttcaaagc tgtgtgatag 2603941 cctttttcta tccctttgct tgtgatttgc caaatcccat tttcgatacg ctcaatgcac 2604001 ctctcttgtt ccaagtcatt taatgcctta aggcataatg aaggggatag gcgtcttttc 2604061 tttcttacac tttcaacagt tacacaaaga ttattctttt catactgttc ataaatcgcc 2604121 aaaagcactt gctccctgct tgttctgcgc cgcagcctca tcagccttat ggctttagca 2604181 gccaatcccc gcttaggcgc gcaaatcatt gaaaaaagaa agagcagcgt tgcagataag 2604241 atcattaatg gccctgtcgc cattcccttc atcgtggtgc taagcagggt tccggccact 2604301 ccgctgaccc cgcctgtaat cccggcaatg atgatcatcc cggttaatcg ttcggtccaa 2604361 tatctcgcgg ttatggcagg tgtaatcagc atagccgcca ttaatatcac accaacagtc 2604421 tgaagcccaa tgacgacagc acagacaatc agacaagcca aaagcccgtt taaaaaacgc 2604481 accgggattc ctaatccctt tgcaaacgcg agatcaaaag taatcaatgt aaattcctta 2604541 aagaaaacaa tacataggag cagtagaaca gcggatatcc ctgcaataag gatgatatcc 2604601 tgcctgacca atgaagcagc ctggccgaat aaaaaagaat caagcccgct ttggcttccc 2604661 gccccctgtt gctgaatata tgtcagcaga atgatcccga cgccaaaaaa cacagaaaga 2604721 acaatcccga tcgccgagtc ctcctttgtt tttgaaagcc gaggaatcag ctgaatacaa 2604781 aacgttccga gcagtccggc gagcgctgcc cccagcaaaa agaaaggcag tgatttttgc 2604841 ccggtgaaca gaaaagcgag acacactccc ggcagagctg aatgggccat cgcatcgccg 2604901 attaaacttt gctttctcag cagcacaaag ctgcccaaaa caccgcttgc cgtcccgagc 2604961 aaaagcgtac cggccagcac ccactgtgta ttcggatgct gaagctgcag ccacaaactt 2605021 tcaaacattg cgctcactcc ttatgtcctt ctgccagcac tttatctttt aaaaacgtaa 2605081 gccttcctcc atatgttttt tgcaggtttt cgatcgtaaa aacgttttcc gtcggtccga 2605141 aagcgatttt ccttaaatga agcagtaaga tccaatcgaa ataatcctcg gcggtctgca 2605201 gatcatgatg gacgacaagc acggtttttc ctttttcttt gagttctgcc aacagcgtca 2605261 taatcgcgcg ctccgtcgct gcatcaacac ctgcaaacgg ttcatccata aaataaatgt 2605321 cagcgttctg gcagagtgcc cgggcaagaa acacccgctg ctgctgtccg cctgacagct 2605381 ggctgatttg ccttttcgca taatcatgca tcccgacttt tgttaatgcg gccttcgcca 2605441 tctccacatc cgctttcttt ggcctcttta ataaaccgat tctcccgtat cttcccatta 2605501 ggacgacatc gagcgggctt gtggggaaat cccagtcaac cgagccgcgc tgcggaacat 2605561 atccgattct ggtccgctga tccttatagt ctttgccgta aatagagatg tctccggaag 2605621 ctctgggcac aagaccgaga atcgttttga tcaaggttga ttttcccgcg ccgtttgggc 2605681 cgataatgcc aataagtttt ccttcaggca cctgcagcga aatgtcctgc agtacaggct 2605741 ttttatgata agcaaccgtc acattatcaa gctcaacagg gaacatatcc tccacctctt 2605801 ttctttattt aagcgcttta gtaatcgtgt tgatattgtg gcggaacatt ccttcgtatg 2605861 tgccttcttt tgtgcccttt tcacccatgg catccgaata aagctgaccg ccgattgtga 2605921 ctgtatggcc tttttcttta gcgccttcca ccactgcatt gattgatttt tcagatacac 2605981 tgctttctac gaacacagct tttatttgtt tttctgtcag aagatcaacc agctcctgaa 2606041 catcccttaa tccatagtcc gaatctgtgc tgagtccctg caggcctttt accttaaatc 2606101 catactcatt cccaaagtac gcaaacgcat catgagcagt cacaagcaca cggcttttct 2606161 ccggaatatg tgcgatctcc ttacgcgacc acttatctaa atattgcaaa tcttctttgt 2606221 actctttggc atttttccga aaggcatctg cgtgctgagg cattgctttg ctgaattgcg 2606281 cttcaatttc atccaccgca tagatccata acggaatgct gaaccagacg tggggatcaa 2606341 acgtcttgcc ttcccccgcg ggaataagct tatttttcgg aatggcctca gctactgccg 2606401 ccgattgttt ttgttcgccg attttttgga ggacatcctc cattttccct tccaaatgca 2606461 acccgctgta cagaacaaca tcggcagaca ttaatttttt cgtgtcacct tgggaagctt 2606521 tgtaaaggtg cggatcaacc cccggtccca ttaaagaggt gacttttacg tgcttacctc 2606581 cgatgttttc tgctgcatcg gcaatttgag atgttgtcgc tgtcacttgt aattgctgat 2606641 cagcgctttt tccggctgaa tccgttccgc atcccgttaa agcaaaggtc gcaaaaagta 2606701 ctgctgccat cagcccttgt ctcatatttc tcctcctctt tgccatcaat gtccgattgt 2606761 tttatcttat gttgtcagtt cttagacatg tgacattaaa ttagccaaaa gcatgtttta 2606821 tttacacagg acaaaaagtt tccctcatgc aaaattatcg cgtttggcca tttttgtcaa 2606881 gctgatttac ataaaaaaac cggctgggtc agcagccggt ccaaacgaga agggatgtat 2606941 tcaacgaaca cttttactgt aacagcacag tgtcatttat tcaaaatagc aaaatgcttt 2607001 tttcttaacc atgctgtgtg aaaacatcca ttttggtcac atattttcgc ataatatctt 2607061 ggtttacctc aacccctaaa ccaggctgtt ttgacacaga aataaatcca ttatcaatac 2607121 gaatatcagg agttacaata tcttcatccc aatagcgtga ggatgaagat atatcgccag 2607181 gtattgtgaa ttgaggcagt gaagcaagcg ccacgttctg cgctcttgat atgcctgttt 2607241 ccagcattcc tccgcaccaa acctgcatat gatgctcttt gcataaatca tgaattttta 2607301 aggcttctgt taagccgccg acacgagaag gttttatatt aataattttg cagcttccta 2607361 gctcaatcgc ccgtctcgca tcatcaactg aacaaatgct ctcatcaagg caaatggccg 2607421 ttttcaaatg tttctgcaag tggcggtggt caacgatatc gtcagcttgg agcggctgct 2607481 caatcatcat taaatgatag tcatcaagct cctttaaacg gctgatatcc ttcagttcgt 2607541 aagaggaatt ggcatcggcc ataagcggga tggttgggaa tcggctgcgg atggccttga 2607601 ccaattccac atcctgccca ggctgaattt taatttttat tctttgataa ccttcttttt 2607661 gatagctctc aatttccttc agcatatcgt caagaggcgc caggccgact accaccccgg 2607721 cagggacttt atctcttgtt ccgcccaatg cctcagcaag ggatacgccc ttctttttgg 2607781 cataaatatc ccatacagcc gattcaagtc ccgcttttgc catccggttt cctttatacc 2607841 gcgccaggct gtccggcact tctgaagggt gattgaattc acggccgacg acatttggga 2607901 taaaaaaatc ttttagcata tgcaaacatg ttccaatggt ttcctcggtg taccaaggcg 2607961 aagagaaagc ggaaacttct ccccagcctg tgacacctga tgtatcaatg gcttccacga 2608021 tcagaaattt acgctcttga agcgtttcga tactgttttt aaacggtttc tttaagttca 2608081 tgctcaaatg gtaaagcgtg attttttcta tttcgatcat agcagttctc ctttacgcgc 2608141 atccttcagc tgatttcgca agagcttatt agacgcattg cgcggcaggc ggtcaagcac 2608201 aaagaatttt gccggaattt tatacttcgc caagcgttct ttgcagtagt cagtcaattc 2608261 tcctgcgctc acaggcttgt gaaggacaag ataggcgtga ggcactttcc cccatttttt 2608321 gtcctcagcc cctgaaaccc cggcttcggc cacagcgggg tgtgaaagca gcactgactc 2608381 cacttcggcc ggataaatgt tttctccgcc ggatatgatc agatctgaac gtctgtctaa 2608441 tacatataaa aagccttcat tgtccaaata accaagatca cctgttttca gccagccatt 2608501 ttgaaaggag gcttcgtttg cgctctcccg gttaaaatag cttttcatga cattcgggcc 2608561 tttgaccatg atttcaccgt gttcatacgg ttcacatacc tgtccgtccc gctctatttt 2608621 gatttcacac gaaaacagcg gtttccccgc agatccgagc ttttccatgc tgaattccgg 2608681 cgacagggta acaatttgcg agcatgtttc tgtcattcca tatgactgaa agacagggaa 2608741 tcctttctca cggcattcct caagcaatgg cagcggtgca ggaccgccgc cgagaagaat 2608801 gcatctgatg gattcagggc agcggtttgt ttcttccaaa agactggcca gcatagtctg 2608861 caccgcagat atcattgtca cttcatgcct gttgatagaa tgcagcacat cgcttacgga 2608921 aaaacgctgg tgaagcacga cagtcattcc atagatcaca gatttaaata atgcggacaa 2608981 tccgctgata tgaaagagcg gcaatgcgat aagccagcgg tcttgttctg ttatacccaa 2609041 attaagagcg gacgacaccg cactgaaata atggtttccg aacgtttgct gaactccctt 2609101 gggctttcct gtcgtacccg acgtatacat cagcgttgcc gttgcatcca tttgcatata 2609161 agcctcgatc tcaatttcct ctgctgcttc tttcatcagt tcatccacat caatcgtttg 2609221 aacgatgtgt tcatattctt tcttctcaaa gcttgaatct gtcaataaaa agccggatcc 2609281 cgaatcctcc agctgaaaca gcctttcatg tgttgacagc ttcgtattca aaagcaccgc 2609341 cttaacacca agcaaaaaac aagcgtgaac agcgtatacc atttctgcac ggttttggag 2609401 caaaatagct gcagtatccc ctttccgaac cgaatgagcg gcaagctgtt ccgccattcg 2609461 tttagacgcg gcaaacaatt ctgcaaatgt cacggtttgg tcttcataga tgagagcgat 2609521 tctctcaggt gtcagctgtg cccgctgcat gagccagttg ggctgttctg tcagcatgtc 2609581 atcatctccg aggtaaaatg tctgtattga aaagaaaaca gcttggaccg caaagtctca 2609641 agctgttggt ttactagata ttgctgatca cggaaaacga gggaactgtc cgaaatcagg 2609701 tttgcgtttt tccttaaagg aatcacggcc ttcttttgct tcatctgttg tgtagtaaag 2609761 aagggtagca tcccctgcaa actgctgaat tccagcaagt ccgtctgtgt ccgcgttaaa 2609821 cgcagcttta agaaagcgca gtgcggtcgg gcttttttca agcatttctt cacaccattt 2609881 aatcgtttct tcttcaagct gttccaaagg aacgactgtg ttgacaagac ccatgtccag 2609941 tgcttcctgt gcgttgtact gacggcatag gtaccagatt tcacgtgctt ttttatgtcc 2610001 tacaattcga gccaggtagc cagaaccgta acctgcatcg aagcttccca ctttagggcc 2610061 tgtttgtcca aaaattgcgt tgtccgcagc aattgtcaag tcacatacga tgtgaagcac 2610121 atggcctccg ccgatcgcat atccggacac catcgcaaca accggtttcg ggatgacgcg 2610181 gattaaacgc tgaagatcca atacgttaag acgagggatc tggtcgtctc ctacatatcc 2610241 accgtggccg cgcacttttt ggtctccgcc agaacaaaat gctttgtccc ctgcaccggc 2610301 aagcacgata accccaacgt tttggtcgtc tcttgcgtca gcaaacgcat caatcatttc 2610361 agcaaccgtt ttaggggtaa acgcattatg tacctcaggt cggttgattg ttatttttgc 2610421 aatgccatta tacgtttcat acaatatctc atcgtatgtc cgttttgttt tccattcagc 2610481 catatgatga cctcctttta ttctctatgt gaatgagtca gatgcttgtc aaaaactcac 2610541 tcactatttt accaaacaat cgcggctgct ccacatggac cgtatgtcct gcttttggaa 2610601 caatctctat tctactagaa ggaagcatct tatgcacctc ttgattgatg gcgcaaaatt 2610661 tttcgtccca ctccccgcag atcagaagca caggaacatc tatttcctct acacggctcc 2610721 acaaggaagg ctgtgaaccg gtgcccatgc cggttaaact gttcgcaagc ccaatcttat 2610781 tgttccgcag acggcccgat cgtatcctgt accgaatatc ttcagccagc ctctgctgag 2610841 atgaaaacaa agggatattc tcccaatacg caacaaacgc ttcgagcccg tctcgtaaaa 2610901 taaaatcagc aagcttccgg tcccgcatga ttcgttcccg ccgttcccca agtgttttga 2610961 gccccggcgt cgtgctttca agcacaagtg ccgatacccg ctcgggatat gtcatcgcaa 2611021 aagagtaagc aagccttcct cccatagaat acccaatcaa tttcactttg tgaagtttta 2611081 attgatcaaa aatctcggca aggtcagaaa cttgccgggt tgtgctgtat cttttcccat 2611141 tcagcggggc atcggtttcc ccatgcccta aacaatcaat tttgatcaaa cgggaatcag 2611201 gcagcatttc atcaagaaaa gtccatgatt gtttgctgcc ggtaaaccca tgcagacaga 2611261 cgacggcttc ggaagcattc ggtccctcgt ctgccactgc atatcggaca ccatctgata 2611321 ccgttatgtt tacagttccc attgtttttt cacttcccgc acagcctcat tcagcatatc 2611381 gcgatgaagc tggactcttg attggcgatc cgttttgatt tcaatcaaat ggagtccggg 2611441 cttgtctgcc tgcggcgcgt aagctgtttt gaattcatcc caagaagccg ggcatgaata 2611501 cgttccgccg taaagtgcag ccgcatgctt gaaatcgagc cctgtcggtg tgccgaacaa 2611561 atcttcaaag tgtgtcttct cagaagcctg cggcaaaaag gagaaaatcc ctcctccgtc 2611621 attattgaca agaatcacag taagaggaat acccagcttt ttggccgcca gcaggccgtt 2611681 taaatcatga taaaaagata aatctccaat cacaagggta acaggcgctt ttgttccttc 2611741 acataccccc atggcagagg agacgacacc gtctatcccg tttgctcccc ggtttgaata 2611801 aatccggaaa gggcggtcct gcttttcaaa aaacgtatca acatccctga tcggcatgct 2611861 gtttcccaca aacagcgagc tgttttcagg cacaagatgc tgaaggattc gatagagatt 2611921 gccttcaaac gaaacatctt cactgctgat tgtttgcaga tgctcgcgga accgcccatt 2611981 gacaaactgc cacttttcca gccactctga ggatctggtg gcagcagtaa ggcctgccat 2612041 gatctcctca gcaaaaacag acgcattaca atgaatcata tgcgcgcttg cctgtgtcgg 2612101 gtctctccac cctccatcct cgtcaatcac gatttgctga atcgtcggat catccttaag 2612161 ccataagaaa accggttttg aaacaggcat cggtccaaac cgaatgacaa catcaggacg 2612221 gagtttccgc ttcagctcat catcttttaa aaacgaatca tacgcatcaa taacagtgct 2612281 tttatcatga acaccattcc gcagattaga cagcggatct gctaaaattg gatactgaag 2612341 cgcttttgac agcgcaataa tgttttcctt gtccgcatca ctatggagct ctccgcagac 2612401 gatcattcct ttttcagcct ctgcgagcat ctcagccaca tcagacaggg actctcggtc 2612461 aacagactgc gtacccgttt tcacagacac atgacggcct gttctcattc ttccaaacgg 2612521 ctcatctgaa agatccggca tcagcggttc gcgcagcggc acattcacat ggacaggccc 2612581 catcgggcgc ttttgtgctt ctccggcagc gcggcttgcc agcgttcgga tgtatctcag 2612641 catttgcgga gactcttcag gaagagcaga gtctgtgaaa aacttaacaa agttaccgaa 2612701 taagaagtgc tgattaatag cctgcggtgc gcctacttcg cgcagctcat gaggccgatc 2612761 agcagttaac acaataatag gcacccttga ataatgggct tcaaccacag ccggataaaa 2612821 gttggccgcg gctgttccag atgtacagat caatagtacg ggacgctgct tcgcttttgc 2612881 caaacctaat gcaaaaaatc cggcagacct ttcatcaatt tggacatgga cgctgatatc 2612941 gggatgcgca gcacaaagaa cagccagcgg tgtagatctt gagcccggac aaacgacggc 2613001 gtccgtaatt ccggaaaggg cgaattcatc aataaaactt ccgatgtaat gagtaatcgg 2613061 gttgactgtc aacgcctctc acctcctaat gcagagatca tcggcttcaa tttaatctgt 2613121 gtttcttcat attccgagat tggttccgag tcttccacaa taccgcaccc ggcaaacagc 2613181 cttgctgtgc ttccttcgat gagccctgaa cgaatggcga ccgcgaattc cccgttatcc 2613241 tggctgtcaa tccagccgat aggggccgca taccagccgc gggacatcgg ttcaatctcc 2613301 ctgatcacgt caacagcttt ttcctgaggt gatcccccaa gcgcgggagt ggggtgcagc 2613361 ttctcaatta agtcaaaaat cgaagcagac tcgcgcagct gtccgacaat cggcgtaaac 2613421 aggtgctgaa cgctttttgt tttgtacaaa acaggtccat caggcttttc aacctctgaa 2613481 cagcttgata caaaagcatt atgaatcata cctaccacaa tatcatgctc aagcaggttt 2613541 ttctcatcgt ttaataattc aaggcctatc cggcggtcgt cttcttcatt cacgcctcgt 2613601 ttaatggagc ctgccagaca ggaagacatg acagtgccgc cgtctctttt gatcagtctt 2613661 tccggagacg cgccgacaaa ggttttgcct tcttgttcaa ttgcaaaaac atagcttgtc 2613721 tgctgatcgt ccagaagcgt tttaagcacc ggttcaattt ggattggacc gtcaaacgtg 2613781 agcagcagct ctcgggcaag aacaacctta tcatattgtt tctctttaat ttggcttgtg 2613841 gccgtttcga ttgctttcag ccaatcatcc ttatccagct cttcggctgc tgcaatcaca 2613901 gcctgatctt cttgcttgaa atcgggaacc ataaattccg ccgcaaaagc ttttaagcct 2613961 tctaaaacag cttctgcgtc ttctcctccg cttacccatc tgttaactgt taagaacggg 2614021 ccttcagcag tcatcgtcag cataagcgca ggcacaaaga aatccccttc cgagaaatgg 2614081 tcccattgtg aacctctttc ttcgcaaggg tcaaaagaaa atcctccgaa taacacaggt 2614141 cccactgcag aatgctgcag cttttcttct tcataaatat gaaaagccgt ctttttaaag 2614201 cgctcccatt gttcaaaaac ctcacgatac cgctcgctgt ttttttgatt tgtctggaaa 2614261 accgcttctt tgccaagacc gactattgtc aattcacttt caggatctga ccaaaaaaat 2614321 cgattgcctg tatatttttt tgctccgtaa ttgaaaaatg atagagggtc aagagactcg 2614381 atttgtctcg aatagcttat taagacagca tggttgactt ctttggcttt atgtaatgca 2614441 tgtagaactt cctttcggaa cgtacgctgc accgttgtca ccatgagaca ttcctccata 2614501 atccttaaaa tgcttttaat accatacacc tgtgtctcct ttgtgtcaaa cacagatcat 2614561 gcagtccaaa tggcctgcct tacctattat aaacctaatt tcagaaatga aaaagaaaca 2614621 aagcttaaat ttctttctcc actgatagca aaggttgtat ccgcttacca taaaaggaaa 2614681 acctcctata ttcctccacc cgccatttat gaaagttctc aggcgatctg ttcatactaa 2614741 aggtatgcat cacagagaaa cgaggcgatc acattgctta cgaaagaaca gcttcagcat 2614801 ttaaaaaatg aactggaaca aacgaaaaaa gatatcttaa accgtttcaa agacaatgat 2614861 cattttcagc ttaactcagc ctttccttat gattcgtggg gtgagctttc ggcatacgac 2614921 aaccatcccg gcgatcaggc gacagaactt tacgagcgtg agaaagacat cgctctagac 2614981 ttgcatgaga gagagcacct tcgggacatt gagcattcat tgaaggcgat agaaaacggt 2615041 acgtatggca tttgtgaagt cagcggaaag gaaatccctt tcgaacgact tgaagcgctt 2615101 ccgactgcca caaccctcgc ggagtattcg tcacaggacg tggtttccaa agaccgtccg 2615161 attgaagaag aaacaccatt cgggcaattt gaatttgatg atgatgaaga aatcagagcg 2615221 ccatatgaca gtgaggattc ctatcaggat gtcgaaaaat atgggaactc acaaacgccg 2615281 caggatatgg aaaaccctcc gctcagctat gatgatatga cgatgaatgc cgaagagaat 2615341 atcggcaata cggagtctta cgaaaatttc atcgctacag atatcactgg gaaagaaatt 2615401 accgtttatc aaagcagagc ccatgagcgc tatgaagaag aacttgacga agagggaatc 2615461 atgaccacat tcggcgatct ccacgctgat tgaaccccca attattgggg gttcttttcc 2615521 gttttcagca tatcgtaaat cagcttcaga taatcctttt gcaggccgat gtcataccgc 2615581 tcgccctcta gcaatttccc gtatacggta catgccccga gcgaagcttt tatcgcatcc 2615641 gttacctgca cttctcctcc gctatcagct tctaatgcct ccagctcatt aaaaatatcc 2615701 ggtgtgaaaa tataacgccc tgctgcggca aaatgagacg gagggttttg tttaggcttt 2615761 tccacaatat cctgtatgcg ataaagccct ttttcaacag gctccccttt tatcaccccg 2615821 taatgatgta aatcctccgt ttttgtttct tttaagccga tcacactgga ctgatatttc 2615881 gtatacgctt caatcagctg ccccaaagcc ggctgattgg cggaaaaaat cagatcatct 2615941 ggcaaaacga cggcaaaagg ctctcctcct gcaaattgct ttccgaaaga aatggcgtcg 2616001 ccaagaccct ttgcataagg ctgccgcaca tagtgaatcc gtatatccgg aatgggatgc 2616061 tctctaagta aatgcagttt attcttagag gccaaaaaag cctcaagtgc caaagaggaa 2616121 tcaaaatagt cgacaatcag atttttatgg ctcgatacaa ccatcaaaat gtcctcaatg 2616181 cctgactcct ttaattcttc aacaagataa tgaatcacag gcttagatcc taccggaaac 2616241 atttctttcg gaatcacctt cgtcaccggc agatttctcg tgccgaatcc gcctgcagga 2616301 atgatcgctt tttttatcat ggtattttcc cctcagctca tgtttattac atgatattcc 2616361 aagagcgcat cccgatgttt gtacatctga aattaggcgg aagcaactgg gcagaaagcg 2616421 gaatcacgaa ccagcccttt tttaatagga tattgatata tgaccagtaa tcttgtaaag 2616481 gagctcaggt gatgaaaatt tgtgtggttg gcgccgggta tgtcggttta accctatcag 2616541 cggcactggc atccatcgga catgacatga tatgcacaga caaagacgtc aaaaaaatcg 2616601 ggcagctgaa aaaaggagtc attccctttt acgagcctgg gctttcagat gcaatacttc 2616661 gttgcggcaa tctctcgttt tcttctgaag tgaaatcgag catggaggaa tgtcccgtta 2616721 tttttatcgc agtcggaact ccgccgcgtt cggacggatc agctgatacg aaagccctgc 2616781 agtccgtcat cggtgattta agcgaggcga tccgatcgta taaaaccatt attacgaaaa 2616841 gcactgttcc gcccgggaca aatgaaaaca tagcaaaaca gctgattgcc tccggagtgt 2616901 ctaaaaacct ctttaatatc gtatccaatc cggagtttct gcgggaaggc aatgccttat 2616961 atgacatgct gcatcctgac aaaacagtca tcggtgttca ggaagaagat cacgtatcgg 2617021 cagccatcgt caaatccatt tacaaacaca ttgatacccc ttttatcgtt acaagcttag 2617081 cgggagcaga gctgatcaaa tatgccaaca atttcttttt agcggccaaa atttcgttca 2617141 ttaacgaaat ggcccgcata tgtgaagcct atcaatcaga tatctcagat atttcccgcg 2617201 ctatcggtct agacccaagg atcgggaagc actttttgca ggcaggcatc ggatacggag 2617261 gctcttgttt tccaaaggat ctgcaggcgc tgcaatttgc tgcccaggaa aaaaacacgg 2617321 agaccttcct gctccgggcc gtgcagcaca ttaatgacac ccagcttggc ctgtatatca 2617381 aaaaaataca gtcattcttc gaaacacttc aaggcaagaa agcggctgta ctcggcattt 2617441 ccttcaaacc gaatactgat gacatccgga attctcaggc tgtcagactg atggaaaggc 2617501 tggcggagct gggatgtgat gttcatgcat atgatcctga agctgtactt ccagaacatt 2617561 tgcggcaaca tgtaactcag cattctcaag cttttgatgc gatcgaagag agtgactttt 2617621 tatttttggc gacagaatgg tctgagtttt tagcgtttga ttggaaaaag gctgcagata 2617681 tcatgaaagg gcgtcttgtg attgacggac gcaacgtact aaaaaaagaa ctgatcgagg 2617741 cttgcggcct gatctgtacg ggagttggcc gtccatgaaa atactcgtca caggagcagc 2617801 gggctttatc ggctcccacc tctgcgaaga attactaaaa gataagaaac ataacgttat 2617861 cggaatcgat gactttatcg gtcctactcc attttccttg aaattaaaaa accttaaaaa 2617921 cctgctgccg gaaaagcgat ttacgttcat aaaggaaaat ctgctgacag ccgatcttgc 2617981 ttccttactg gaaggagtgg acgtcatctt tcatttggcg gccataccgg gtgtccgctc 2618041 aagctggggc aatcattttc acccatatgc cgcacataat atccaagcgc tccaaaggct 2618101 cctcgaggcg tgccgggaac attctattca aacgttcgtc tttgcatcca cctcttccgt 2618161 ctatggcgaa aaacaaggaa aagtcagcga aaacacgtcg ctttctcctt tatctccgta 2618221 cggggtaaca aagcttacgg gagaaaagct ttgccatgtg tataaacaga gctttggcat 2618281 tccaattgtg attctccgtt tttttaccgt atacgggcca agacagcggc cggatatggc 2618341 ttttcaccgg ctcattaagc agcaccttca gcaaaagccg cttaccatct tcggtgatgg 2618401 gcagcagtca agagatttca cttatatcag cgactgtgtc aaaggcatca ccgctgttct 2618461 tgggaaaccc caccttattg gtgaaacagt aaatatcggc ggcgcagagc gtgcctcagt 2618521 cttaaaagtt gtctccctca ttgaggatat ttccgggaga aaagcaacac tgcacttttc 2618581 ggacaaaata gcaggggaac cgagcaacac gtgggcggat atttcaaaag caaaacagct 2618641 cttgcattat gatcccgcca catccttaaa ggatggcttg accaacgaaa tcgcctattt 2618701 atcgtcgctg tatcaggggg aataaaaatg aagcttgcct ttatctgtac agaaaagctg 2618761 ccggcgcccg cagtacgcgg cggcgctatt caaatgatga ttgacggtgt cacgccctat 2618821 ttcagcagca ggtacgacct gaccattttt tcaatagaag atccatcgct cccaaaaaga 2618881 gaaacaaaag acggcgtaca ttatatccat ctgccaaaag aacattaccg cgaggcggta 2618941 gccgaagagc tgcgagcctc ttcctttgac ctcattcatg tgttcaacag gcctttaaat 2619001 gtctctttat ataaaaaagc ctcaccaaac agcaagatcg ttctgagcct gcataacgaa 2619061 atgttttctg aaaaaaagat gaccttcgcg caaggaaaag aagtactcga caatgtctcc 2619121 atgatcacaa cagtgagcga atttattaaa caaaccgtca ttgaacgttt ccctgaagcc 2619181 gaggacatca caaaagttgt gtattccggc gttgatttaa actcttatcc gcccgtctgg 2619241 acgatgaaag gctcggctgt cagaaaaaca taccggaaaa aatacggtat tgaagataaa 2619301 aaagttattt tattcgccgg ccgcttaagc ccgacaaaag ggcctcacct tctcattcac 2619361 agcatgagac ggattttgca gcagcaccct gatgctgtac tggtcatagc aggcgggaag 2619421 tggttcagcg atgacagcga aaaccaatat gtcacctatc tgcgcacgct ggcgctgcca 2619481 tacagagacc acataatctt tacaaaattc attcccgcag acgatatccc aaaccttttt 2619541 ctgatggcag atgtatttgt gtgcagctct cagtggaacg aacccctcgc ccgtgtgaat 2619601 tatgaagcaa tggcggccgg cacgccctta attaccacaa accggggcgg aaacggtgaa 2619661 gtcgtaaaac acgaagtcac cggccttgtc atcgatagct acaacaaacc ttcttcattt 2619721 gcaaaagcaa ttgacagagc ctttacagat caagaattaa tgaacaaaat gacaaaaaac 2619781 gcccgaaagc atgtagaagc tttatttacc tttacccatg ctgccaaaag gctcaatact 2619841 gtttaccaat ccgttctgac cccgaaaaac aaacaatttc cgccgccttt tctgacgcaa 2619901 aattttgatt tatcatctat caatcagctt tttgtgaaag caaaaacata aaacctacag 2619961 ctcgtgttgc aaaacgggct gttttttcgc tacagagaac ttaaaaaaag gcataaatgt 2620021 gactttatgc cttgcgcttt acagtttgag aaaaccatgg agctggttta gattcacttg 2620081 gaagaatgat gatttccact ttagcttctt ccgctaagtc tggttcttca tcttcatcct 2620141 cttcttcata tgggggcgct gagcgtttcg aatcacgctc ctcctcaggc tccagagtgg 2620201 tttcgaattt tgtttcttct tcatcatcga cgattttgcg atctgtttcc ttttccttcg 2620261 tttctttttg atattctttc ggtgcattga tgtgagggag ctctcgaatg ctgcccacat 2620321 ctaaatgctt ctcctcttct tccttctcag ctgagattga gtcatgagcc tgccatccca 2620381 tcggtccagg cggtgtaaat acgaattggt cgagatccag tttagaaata gaggcttttt 2620441 gtctcgatga cctcatgtca attcgcctcc cgatacgctt ttatcttttt atacagttcc 2620501 ggcagtttat ccaaaaacga atctttagat tcttcaacag aaatcatgtt ttgcagcgcc 2620561 cagttatact tctcatctga ccacgttttc ttttgcttca aataatattt gtgcccgatt 2620621 gcacagaaca aatgcggaaa cgcgagatca atccaaagta cctcgtactg tttttctgtg 2620681 agcggataca ctgcgtcgta ggccgcaagc agtgcaacca tgaaatcagt atcccataca 2620741 gaaagcttaa ccatcacttt attcagcaga atacgaaggt ctcttgacgg caaatcgtag 2620801 gtaatcgagt gaagctcctt taaaaaaggc tccccttcga tctcagtcaa acgtgccaat 2620861 gtaaaatcct gaaaacagaa tccgccatgc tcgagtgtct cttttgtcca ggtttcgtat 2620921 tctgagtcat caagcgctct gagagcttct tttcctcttg ccagcatttt atcagcatgt 2620981 tttaagaaag tttgcgaaaa tacgtcatca ggataggatg ctgcgatctg catattccct 2621041 tcaagttcct gcagcttcca acggtacaat ttgtgccatt ttcccagcct gcttctcttc 2621101 ttgctttcat ctgtgcaaac atatcctttt gaggcatgat gaaaatggcc ggcaaatgac 2621161 atgacttttt tcatttgctc tgcatcatag taaatcattt cttttcctgt cactttgtca 2621221 tataaactgt aagaaacctg atccgtgccc aagcagctac cgccattttt tgtttgatga 2621281 atcggcgcta tcggcagccc tttctcttgt aaatgggcgt gtgcctgagt gataaaaagc 2621341 atccgctccg gtttcatttg cgcttctttt agcagctttg ggccatgatc agtttcgact 2621401 tcccagattt tgcgcccgct tttgttcgat ttcagcgcca catggtcgat atgaaacgga 2621461 taataactga gaatttcgga cacaatctgt tcttcatgct ctttttggta cactctgttc 2621521 accccttcta tctgttcttt tcatagacgc tgagcagatt ttcagccacc ctctgccagc 2621581 caaaattgct ttctgcctca cggcggctgt atttcccaag ccgttcccgc ttttccgagc 2621641 tgctcagcaa atcattgata cgttcggcat attgtttagg attttcaaag tcatgaatga 2621701 tgtagccgtt tttcccttcc tctatgacct ctggattgcc tccccgattg cttgtaataa 2621761 taggaagtcc cgcagccatc gcttcataat gcacccttgc taaaggctcc tgccattgcg 2621821 aagagcatac aaatacatct gacatggtat aaaggcgcgg aatgtccttt ggcttcacaa 2621881 attgaataaa tgtgacatga tccttttgca tcgcaccaag ggtatgaaga tgtttgacat 2621941 agttatttaa ttcattatct ccgaaccatt ttgacccgat aaacaccatc atgacatcgg 2622001 ggtgctcctc aatgatgtcc ggcaaagcct gcaataatat gtgcgggcct ttgactttgc 2622061 taagccggcc gacaaacaag acgatttttt tgccgtgaag ccccagctcg cttcgcatct 2622121 cttcgcgagc tcgctgccct tcattcgtcc agcgagggtg gtacgttttt aaatccacac 2622181 cagaatacac cgtttttgtt tttgatcgtg ctgacggaaa acggcttgtg atcgtctgtc 2622241 cgatataatc gctgaccgta acaatctgcg ctacggagtc gatgcaaatc tcgccttccg 2622301 cctggctgat tttatcgtaa gcgaacattt cattgtgaac gcttaaaata aaaacagcat 2622361 ccggcgcctg tttcttcaat ttcggaaccc agcttgggcg attacaaaca tgcacaagat 2622421 caaaacggct ctttttcagc tctgctccaa cggcttcttc ataacggtct tcatccaaat 2622481 gcacataatg gacaccgtct accttctctc tatcagcgag attcggatct ttaatagaaa 2622541 acacagtcac ctcatgtttt tttgcaatta aaggggcaac cgcttcgagg tagatttgaa 2622601 tggcgcctcc tcgaaccgat gggacaggaa gcttctctgt ggcgatcagt gctattttca 2622661 tacatagcct ccattcctgc atgattttta actagttaga atcatgatac ggctgaacaa 2622721 ccaacttgtg cggaatggga ctgccctaaa aacaaaacgg gtaaacaacc agattcatct 2622781 attaaatata gtcaaataac tcaatcattt tttccttttg attcataagg taggagtaaa 2622841 acaggtaagg atgtgtcctt taatggcaga aaaccatgaa gtcattgagg aggggaattc 2622901 atcagagctt cctttatcag cagaagatgc aaaaaaatta acggagctgg ctgaaaatgt 2622961 gcttcaagga tgggatgtgc aggctgaaaa aatagacgtc attcagggaa accagatggc 2623021 gcttgtctgg aaggtccaca cagactccgg cgcggtttgt ctaaaacgaa tacacaggcc 2623081 agaaaagaaa gcgttgtttt ccattttcgc gcaggactat ttagcaaaaa aaggcatgaa 2623141 tgttcctggc atactcccaa acaaaaaagg cagcctatat tctaagcacg gctcatttct 2623201 atttgtcgta tatgactgga tcgaaggaag accgtttgag ctgactgtaa agcaggactt 2623261 ggagtttatc atgaaaggcc ttgctgattt tcatacagct tccgtcggat atcagccgcc 2623321 aaatggcgtt cccatattta ccaaattagg tcgctggccg aatcactaca cgaaacgatg 2623381 caaacagatg gaaacgtgga agctgatggc ggaggcggaa aaagaagatc ctttctcaca 2623441 gctttatctt caggagatag atggctttat tgaagacggg ctgcgcatca aagaccggct 2623501 tttgcaatcg acctatgttc catggactga acagctgaaa aaaagcccta acctttgcca 2623561 ccaggattac ggaaccggga atacactctt aggagaaaat gaacagattt gggtcatcga 2623621 cttagatacc gtatcatttg atctgcctat tcgcgatttg cgcaaaatga ttattccgct 2623681 tttggatacg acgggtgttt gggatgacga aacatttaat gtcatgctga acgcatacga 2623741 atccagagcc ccattaactg aagaacaaaa acaagtcatg tttattgata tgctgtttcc 2623801 ttacgagctt tacgatgtca ttcgcgaaaa atacgtccgc aagtctgctt taccgaagga 2623861 agaattagaa tcagcttttg aatatgaacg cattaaagca aacgcattgc ggcagcttat 2623921 ttaagaccat catttccccc gcatatcggg ggtttgatat ttataagata aagggtaatt 2623981 aaatacatgc ggaggttgca aatatgaaaa agattgtcgg cgctttagcc gtttttgtga 2624041 ttacatatgc gctgttttca gccgcaggct acctgtttcc tgtggaccaa gaatggtaca 2624101 attcattgaa aaaaccggac tggacgccaa gcggaactgc gatcggcatc atttgggcca 2624161 tcctgtttgc cctgatctcc ctttcagcag ccattgtata tgctgcgttt tcatttaaag 2624221 gtgcgaaaag cttttggttt acacttttga taaattacgt gctcaatcaa gccttcagct 2624281 atttccagtt tacgcaaaaa aatctgctgg ctgcatcgct tgactgcctg cttgtcgcca 2624341 tcacagcaat cgtattactg atcattgcca aaaaatacag cagagccgca agctatcttc 2624401 ttttgcctta ttttttatgg agtgcatttg cgacgttctt atcctttaca atcaattcaa 2624461 tgaatctgtg aacaaaaaaa gccgcttata cagcggcttt ttcacatcat cggcttgatg 2624521 ccccaaatgt ccttcgcata ttcccggatc gtgcggtcgc tggagaaata tccagaatga 2624581 gcaatgttta caatcgaatg ctcagaccat ttccttcgct ctcgataatc agcttgaatt 2624641 cgctcctgtg catctgcata tgagctgaaa tccttcagca caaaatactc atcattatgc 2624701 ggaagcagcg agtcaaagat cgattcaaat tcatctgcct ctccttcaaa aaaaccattg 2624761 atcaactgat ccgctacctg cctgattctc ctgtcatgct gataatattc cctcgaccta 2624821 tagccgccgt tttcctgata cgatagaacc tcatccgcct ttaagccgaa cgtgtaaata 2624881 cagtcagggc ccacccgctc aaggatctcg atatttgcgc cgtcatgcgt gccgatcgtc 2624941 aaagccccgt tcatcataaa cttcatattc cctgtaccag acgcttcctt gcttgcggtt 2625001 gaaatttgct cacttacgtc tgatgccgga aaaattcgct cagccataga aactctataa 2625061 ttttctaaaa aaacaacttt gatcagctgt ttgaccgccg gatcataatt gactttttct 2625121 gcgacagaat ggatcagctt aatgattttc ttggcataat aatagcttgg tgaagccttt 2625181 gccccgaaaa taaaggtttg cgggtagatt gaaaaccccg aatcctcctt gaggcggtta 2625241 tacaaataca taatgtgaag aacattcagc agctgccgtt tatatgcatg aagccgtttc 2625301 acctgtacgt cgaatatgct ctcagggttc acaaccaccc cggccgtgca aaaaatcaaa 2625361 tcggcaagct cttgtttttt cttgcttttg ttgttttgaa actgttcaat aaatgcagga 2625421 tcagtggcgt acggttctaa acggatcagt gattccggct gcttgaccca ttcatcgccg 2625481 atcgcctctg taatgatggc agacaagcct ggattcgctt ttaacagcca gcgcctgtgg 2625541 gcaattccat tcgtcttatt gttaaaacga ttcggaaaca gcaagtgaaa gtcgcgcatc 2625601 tccctttcct ttaatatatc ggaatgtatt tttgcaacgc catttacact gtagctgcct 2625661 actatggcca gatgagccat tttgacaaca ccatgcgctg taatcgccat gttctctatc 2625721 cttttccagt ctccaggata cttttcccaa actgcacggc aaaacctctc attgatctct 2625781 tcaataatca tgtacattcg cgggagcagc ggcttaaaca aatgaatcgg ccatttctcg 2625841 agcgcttctg acaatgttgt atgatttgta taagaaatcg tatgtacagt gatatgccaa 2625901 gcttcttccc agctcatgtt ctcttcatcg agcaaaatcc gcattagctc aggcaccgca 2625961 agcgcagggt gagtgtcatt aatatgaatg ctcacttttt tatgcaggcc ggataaagat 2626021 ttatgtgttt tacggtaatt gttcacaatg ctttttaagc ttgcgcatac taaaaaatac 2626081 tgctgcttca gccgtaaaat tttcccctca tcatgggtgt catcgggata taagaattca 2626141 gaaaccgctt ctgtttctcg cttataagac aaaatattac cgccgtgata atgggcatag 2626201 ggctcggcgt tccaaagcct taacgtgttg acagtgcccg tttcatagcc gatgatcggg 2626261 atatcataag gaacagcggt aacaattgtc gcttgttcat ggcgaaaatg caggcgcccg 2626321 cttttttctg tcatatggac ttcgccccaa aacggcacgt ccactgcttg atccgcattc 2626381 cttacttccc atacgttccc gtttttcagc cattgctcag gcagctccac ctgatgtccg 2626441 tctacaattt tttgctcaaa caaaccatgc ttataacgta tgcccatgcc gtgcccaggc 2626501 aggttcaacg aagcaagcga atctaaaaag caagcggcca agcgcccaag tccgccattg 2626561 ccgagacctg catcgttctc tatctgaagg atctcctcta aattgatgcc gatttccttt 2626621 aaaccagctt ctacaacatc acgaacacca agattcatta agttttgctc aaggagctga 2626681 ccgagcagaa attcgattga taaataatat gtctgcttcc cggaatttga tctgcttttt 2626741 tcattcgttt cgatccaatc agcgctgata tactctctga ccatattgcc caacgtttta 2626801 tattgatcca gcttggcaga atctttaaag ctttttccgc acgtcatttc cagacgcttt 2626861 aaaaataagt ctgcaaagcg ttctttactc gagaacatcc cgtccactcc ttgtcacctg 2626921 ctcgaaaata cgctgatact ctttagccga cttcccccag ctgtaatctg cattcatagc 2626981 ggtcttcacg atgctcttcc atacatcctg ttggcaataa aacgacagcg ccctttctat 2627041 cgtaaatttc agatcatgcg cattaaaggc ggaaaacgta aagccattgc ccgttccctc 2627101 ttcctcctga taggcacgga cagtgtcgta aagaccgccc gtttccctga caatcggaat 2627161 ggcgccatat tgaagagcaa tgagctgccc caaaccgcac ggctcaaatt tcgacggcat 2627221 caaaaacata tcagagcccg cataaatttg atgggctagc ggctcatcaa acccgatata 2627281 agcccggcac ttctcatgaa aagcaaattc tgcataccgg aaataatctt caaattcacg 2627341 ttctcctgtg cctagcacaa ccagctgtat gtcttgctcc tcaagaagtt cgtgcataat 2627401 tctgcggaca agatcaagcc ccttttgttt agtgagcctt gtcaccatac tgatcagcgg 2627461 aatatcgttt ttctctggaa gccccatccg ctgctgaagc ttcgttttgt tttccagctt 2627521 gcatgcaaga tcccctgaat cgtattgcgc ctctatataa gggtcgcttt tcggctgata 2627581 gaacgtatca tcaatgccat ttaatatgcc ggttacatca tcttccctat attgcaaaac 2627641 ctgttccaac tgctcaccat aatacggcgt catgatttca tttctgtaag tggggctcac 2627701 agttgtcaca tgatcagccg caatgatgcc cgctttcata aaattaacaa atccgttgca 2627761 ttctaacctt tcataatgaa aatgatccat ctcaagaccc agcaagtcat gtgtgacatc 2627821 aggagggaat atgccttgaa actgcaggtt gtggatcgtg agcacgcttt tcatccgttc 2627881 ataaaaagga tgttttctgt actcctcttt cagcaaataa ttgaccatcg ctgtatgcca 2627941 atcgtgagta tgaacaatat cggcttgaac attcacaact ttggcagcct ccagcacagc 2628001 tcttgaaaaa aaggcaaacc gctcaccgtc atcataatgc ccgtacaacg aatccctgtt 2628061 gaaatagtac tcattgtcga tgaagtaata attcacatca ttctctgcca tatgttcaat 2628121 tccgcaatat tgctgccgcc agccgacagc tacggtacac tcagcctgtt ttttcatacg 2628181 ctttttccac ggttcaggta tttggctgta cttcggcagc atcacagcta cctcattgcc 2628241 taatcgcgca agcgcctttg gcagagcacc tgctacatcg gcaagacctc ctgatttcac 2628301 aaatggggtg cattctgaca cagcaaataa tatcttcaag aattcatcag ctctccttgc 2628361 accaaacctt ttcttaatac aagcggctgc tcagctgttc ctgcagcttc cgtcgccttg 2628421 ccgattttaa catccttatc cgaaatgacc tgctcaagaa gacaatcctc tccaatctgc 2628481 gttttttgca taataatgca gtttttcagc ttcgtaccct ttccgacatg gaccgccctg 2628541 aacaaaatgc agttttcaac ctctccttca agcacacagc cgtttgccac caaagaattt 2628601 ttgacagtgc tgtgctttcc gtatttcgta ggcggctcat ccttcacttt tgtatagatc 2628661 ggctgctgcg gcaaaaacac ctgctgccaa aaacgaggct gaatgagctc catactgtgg 2628721 gtataatatt tttccaccga atcaatgaca gcggcataac ctgaatattc ataagggcaa 2628781 atggtcaggg cggaagattc cttttcaaca gcctcctgaa tggttttata gcctttttcg 2628841 ctatgtccgt agatcagatc ctttaaaagc gttgttgaca tgatatagat ttgcagcgac 2628901 tggccgtcct gaaatacctc ggtgacgtcg cagccaacct cctgatggcg tttcagcaca 2628961 tattgaaatt gaatgttgca tacggtatgg ctgttggaga ttacagcata ttgctgagtg 2629021 cttctgtgga agtaatctag atggtccgaa aactggcgaa aggaaccgaa ttcatcgtat 2629081 tcgtgatgaa gatggggaga cgggaaaaaa aagaggccgt cctttttccg gtgcaaatcc 2629141 cattccttac ccgccccaag gtgatccatg agcgaacggt aacgatactt cggaaaaatt 2629201 gcaacactcc taatatccgc attcaccatg ttggaaagca taaaatcaat cagtcggtac 2629261 ctgccggcaa aagggatcgc cccgagcgac cgctgtgctg ttaaatcctg aagagaatgc 2629321 ttatatgtgg tttcatctat aacacctaac atttgattat tgaacactga ctctgccccc 2629381 tcttcagtaa ttaaatcaat tctttttcta caaattcctc tgaaacgagc agcacctctt 2629441 caatgtcttt ttcggagcga atcactgcgc catccggcag caccatccca ttaggaacga 2629501 tggcattttc aatgactaca tgctccccaa tcgtcacatc cggcattatg acggatgatg 2629561 taacagtcgt atgcttacca acagtcacac cttgaaaaag aacggagtga gacacatttc 2629621 catatacaac acaaccttcg ttcacaagcg aatcttgaac ctgcgcatca gatgaaataa 2629681 attgcggagg ctgatttgga ttgacggagt aaattttcca tttgcgttca aacagcttca 2629741 gctccgagtc ctcttttaac aaatccatat tggcttccca caagctctgc accgttccga 2629801 catccttcca atatcccttg aacggataag cagaaagctt ctttttctct tccaaaagca 2629861 gtggaataat gtctttgccg aagtcgtggc tagaataagg gttttgatcg tccatctcaa 2629921 gatactgttt caaaagcggc caattgaata tataaattcc cattgaggca agattgctct 2629981 tagggaattt gggcttttca tcaaaatgtg tgatcgtccc atctggattg gccttcatga 2630041 tgccgaaccg gcttgcttcc tcccagccca cttcgatgac agagatggtc acatctgctt 2630101 tcttttcaat gtgataatca agcattttgc cgtagtccat tttgtatatg tgatctcctg 2630161 ataaaatcag tacatactca ggatcatact gattcaaata attgagattt tcataaatgg 2630221 agcttgccgt ccctttatac catttgactt ctgatgactc ggcataaggg ggtaaaaccg 2630281 tcacgccgcc attatatcta tccaggtccc atgcactgcc gatcccaata taggaattca 2630341 gctcgagcgg ctgatattgc gttaaaatcc cgactgtgtc tatgcctgaa ttagaacagt 2630401 tgcttagggt aaaatcaata atcctgtatt ttcccccgaa agatacagcc ggtttggcca 2630461 tattttttgt taatccgctg agacggctgc ccttcccgcc ggcaaggagc atggctacac 2630521 attgtttttt catcttttta tctctcctct ttttttaacc gcccgtaaaa tcgagatgcc 2630581 gtaagggggg atggtcatcg tgatataaca cggtttatga tgaagtgctc cctttttagc 2630641 cgataacggc tttttgttga tttgccctga gcctccatat gtttcactgt cactgttaag 2630701 cacttcaatg tattgagtaa aaaaaggaac tccaacatca tattgatgat agaccacggg 2630761 tgtaaaatta caaatgatga caagcgcctc accgtgcttt tggccataac gaataaaaga 2630821 aaagattgat tgttcgtcat tatggacatc aatccattca aacgattgtg cacgatggtc 2630881 atgctcataa aggattttgc ttttttggta aaagcggaga agatcttgcg taaaaacgct 2630941 ggctttctga tgcatgggga aggagtccaa aaaccaatca agctgttctg tatctttcca 2631001 ttcatcaaat tgagcaaact ctgatcccat aaagatcaat ttctttccgg gatgcactgt 2631061 catatagccc agcaaaagcc gatactgggc aaatttctgc cagtagtcgc caggcatttt 2631121 attgagaagt gatttttttc cgtatacgac ttcatcatga gaaaacggca atacaaaatg 2631181 ttcactaaac gcatatagta atgaaaaaga gataagctga tgacaatgcc gcctttcttc 2631241 gggcggcgtc tccatgtatt tcagtacgtc attcatccat cccatattcc atttataatg 2631301 aaaaccaagc cccccttcct caacggcacc tgtcacttga ggccattctg tagaatcttc 2631361 tgcaatcatc atcacatggg gatatgcctc tctcatggtt tgattgagtt tttttaaaaa 2631421 atcaacagca tatggattcg tgtggcgttc atcctgattt ggccaataca agatattagc 2631481 cactgcatca accctaaatc catctatatg atagaattcc gcccagtaca acgcattcga 2631541 aattaaaaaa ctatgaactt ccggtttccc caggtcaaag tttgccgtgc cccataacca 2631601 gttctcccga tcacgttctt ctttgtattc ataaagcggt tctccatcaa acatataaag 2631661 gccatgtgca tctttacaaa aatgtccggg gacccaatcc aaaatgactc cgatattttg 2631721 ttgatgacat tcatccacaa acttcatcag atcatgcggc gggccaaacc tgcttgtcgg 2631781 gctgtaatac cccgttcctt ggtaccccca tgaacgatca tatggatgct catacacggg 2631841 aagcagttca atatgggtaa acccatgctt cttgatataa gggataagcg tctgacttaa 2631901 ttctttatag gaataatgcc tgccatcaga atgcttcttc caagacccaa gatgcagttc 2631961 ataaatgaaa acaggttttt catacagcgt cttagccttc tgtttctttt gccatttttg 2632021 atcttgccag ctgtatcctt ccaaatcgta agtaagtgac gctgtgtttg gtctgacttc 2632081 tgaataaata gcgtatggat ctgccttcag cctgatctca ccgttattcg tcacaatttc 2632141 gtatttatat cgttcctttt ctcctatacc tggaataaat aacgtccaaa tgccattatc 2632201 attcactctg tgcatcacat gctcttctcc agaccagctg ttaaaatctc cagccactcg 2632261 tacttccgac gcatgaggcg cccacacaca gaattcatat ccgcttttgc cattcagctc 2632321 gcggtaatgc gagccaaaca gctgatagct tttaaacaga ctgccttcgt gaaaaagata 2632381 aacatcatgt gctgtcgggc tggcagcggc catgtaatca tcctttctga catcatagtt 2632441 ttcatttata gtatttattc gaagaaataa aaaaaagccc tttcctgaaa gcgcttatac 2632501 ttatagacaa ttaacttcat tttctgaaga aaaacgaaat atatggagat ttttgtagtc 2632561 tgtttttaaa ataaagaaca aaatctaaga catatcatga tttataaaaa caaaaaaacc 2632621 ttgcaggata tgcaaggctt ctggatgacc cgtacgggat tcgaacccgt gttaccgccg 2632681 tgaaagggcg gtgtcttaac cgcttgacca acgggccgat aattatgata tctgtaatca 2632741 tatggcggag aaggagggat ttgaaccctc gcgccgctta cacgacctac acccttagca 2632801 ggggcgcctc ttcagccact tgagtacttc tccatttggc tccacaggca ggattcgaac 2632861 ctgcgaccga tcggttaaca gccgatagct ctaccactga gctactgtgg aacaaaagtc 2632921 atggtgggcc tgaatggact cgaaccatcg acctcacgct tatcaggcgt gcgctctaac 2632981 cagctgagct acaggcccat gacgatatag aaatggagcg ggtgatggga atcgaaccca 2633041 cgacatcagc ttggaaggct gaggttttac cactaaacta cacccgcaat ttttatttgg 2633101 ggcgattgat gggaatcgaa cccacgaatg ccagagccac aatctggtgc gttaaccact 2633161 tcgccacaac cgccaaagca tattgataaa tggtggctcg ggacggaatc gaaccgccga 2633221 cacacggatt ttcagtccgt tgctctacca actgagctac cgagcctaag tatttaaatg 2633281 gcggtccgga cgggactcga acccgcgacc tcctgcgtga caggcaggca ttctaaccaa 2633341 ctgaactacc ggaccatttt aaaatttggt tgcgggggca ggatttgaac ctgcgacctt 2633401 cgggttatga gcccgacgag ctaccgaact gctccacccc gcgatgatta ggaatatgta 2633461 tggcggagga agagggattc gaacccccgc gggctttgac acccctgtcg gttttcaaga 2633521 ccgatccctt cagccagact tgggtattcc tccgtatagt ggtggacctt gtaggactcg 2633581 aacctacgac cggacggtta tgagccgtct gctctaacca actgagctaa aggtccattg 2633641 gtagcggcgg aggggatcga acccccgacc tcacgggtat gaaccgtacg ctctagccag 2633701 ctgagctaca ccgccaaata tttttgaaat caagtggagc ctagcgggat cgaaccgctg 2633761 acctcctgcg tgcaaagcag gcgctctccc agctgagcta aggccccaag aatggtcggg 2633821 aagacaggat tcgaacctgc gaccccatgg tcccaaacca tgtgctctac caagctgagc 2633881 tacttcccga tttcatatag atcatggcgc gcccgagagg agtcgaaccc ctaacctttt 2633941 gatccgtagt caaacgctct atccaattga gctacgggcg caaaacttaa tgccgagggc 2634001 cggacttgaa ccggcacggt agtcacctac cgcaggattt taagtcctgt gtgtctgcca 2634061 attccaccac cccggcgtgg atggtatagt tggagcggaa gacgggattc gaacccgcga 2634121 cccccacctt ggcaaggtgg tgttctacca ctgaactact tccgcagaaa tggtgcggat 2634181 gaagggactt gaacccccac gtctgtaaag acactagagc ctgattctag cgcgtctgcc 2634241 aattccgcca catccgcaac atgtaaatgg tgagccatga aggactcgaa ccttcgaccc 2634301 tctgattaaa agtcagatgc tctaccaact gagctaatgg ctcttcttac aatagacttg 2634361 aatattatat catataaaag tggtgccggc aagaggactt gaacccccaa cctactgatt 2634421 acaagtcagt tgctctacca attgagctac accggcatat atgtaaaacc gatatgtata 2634481 atgaaaaatg gtggaggatg acgggctcga accgccgacc ctctgcttgt aaggcagatg 2634541 ctctcccagc tgagctaatc ctccatactt gcactaacgt gcaattgctt ggcggcgtcc 2634601 tactctcaca gggggaaacc cccgactacc atcggcgctg aagagcttaa cttccgtgtt 2634661 cggtatggga acgggtgtga cctcttcgct atcgccacca aacaaattga gagtgttctc 2634721 tcaaaactag ataacaggtg tgacatcatt caaaaatatg gttaagtcct cgatcgatta 2634781 gtatctgtca gctccatgtg ttgccacact tccacctcag acctatcaac ctgatcatct 2634841 ttcagggatc ttacttcctt gcggaatggg aaatctcatc ttgagggggg cttcatgctt 2634901 agatgctttc agcacttatc ccgtccgcac atagctaccc agcgatgccc ttggcagaac 2634961 aactggtaca ccagcggtgc gtccatcccg gtcctctcgt actaaggaca gctcctctca 2635021 aatttcctgc gcccgcgacg gatagggacc gaactgtctc acgacgttct gaacccagct 2635081 cgcgtaccgc tttaatgggc gaacagccca acccttggga ccgactacag ccccaggatg 2635141 cgatgagccg acatcgaggt gccaaacctc cccgtcgatg tggactcttg ggggagataa 2635201 gcctgttatc cccggggtag cttttatccg ttgagcgatg gcccttccat gcggaaccac 2635261 cggatcacta agcccgactt tcgtccctgc tcgacttgta ggtctcgcag tcaagctccc 2635321 ttgtgccttt acactctgcg aatgatttcc aaccattctg agggaacctt tgggcgcctc 2635381 cgttaccttt taggaggcga ccgccccagt caaactgccc acctgacact gtctccccgc 2635441 ccgataaggg cggcgggtta gaaggtcaat acagccaggg tagtatccca ccgatgcctc 2635501 caccgaagct ggcgctccgg tttccaaggc tcctacctat cctgtacaag ctgtaccaac 2635561 attcaatatc aggctgcagt aaagctccac ggggtctttc cgtcctgtcg cgggtaacct 2635621 gcatcttcac aggtactata atttcaccga gtctctcgtt gagacagtgc ccagatcgtt 2635681 gcgcctttcg tgcgggtcgg aacttacccg acaaggaatt tcgctacctt aggaccgtta 2635741 tagttacggc cgccgtttac tggggcttca attcgcacct tcgcttacgc taagcgctcc 2635801 tcttaacctt ccagcaccgg gcaggcgtca gcccctatac ttcgccttac ggcttcgcag 2635861 agacctgtgt ttttgctaaa cagtcgcctg ggcctattca ctgcggctct ctcgggcttg 2635921 caccctaaca gagcacccct tctcccgaag ttacggggtc attttgccga gttccttaac 2635981 gagagttctc tcgatcacct taggattctc tcctcgccta cctgtgtcgg tttgcggtac 2636041 gggcacctct cacctcgcta gaggcttttc ttggcagtgt ggaatcagga acttcgctac 2636101 tatatttcgc tcgccatcac agctcagcct tatgggaaac ggatttgcct atttcccagc 2636161 ctaactgctt ggacgcggat atccaatacc gcgcttaccc tatcctcctg cgtcccccca 2636221 ttgctcaaat ggtgaggagg tggtacagga atatcaacct gttgtccatc gcctacgcct 2636281 ttcggcctcg gcttaggtcc cgactaaccc tgagcggacg agccttcctc aggaaacctt 2636341 aggcattcgg tggaggggat tctcacccct ctttcgctac tcataccggc attctcactt 2636401 ctaagcgctc caccagtcct tccggtctgg cttcacagcc cttagaacgc tctcctacca 2636461 ctgttcgaag aacagtccgc agcttcggtg atacgtttag ccccggtaca ttttcggcgc 2636521 agagtcactc gaccagtgag ctattacgca ctctttaaat ggtggctgct tctaagccaa 2636581 catcctggtt gtctaagcaa ctccacatcc ttttccactt aacgtatact ttgggacctt 2636641 agctggcggt ctgggctgtt tccctttcga ctacggatct tatcactcgc agtctgactc 2636701 ccaaggataa gtcattggca ttcggagttt gactgaattc ggtaacccgg taggggcccc 2636761 tagtccaatc agtgctctac ctccaagact cttaccttga ggctagccct aaagctattt 2636821 cggagagaac cagctatctc caggttcgat tggcatttca cccctaccca cacctcatcc 2636881 ccgcactttt caacgtgcgt gggttcgggc ctccattcag tgttacctga acttcaccct 2636941 ggacatgggt agatcacctg gtttcgggtc tacgaccacg tactcatgcg ccctattcag 2637001 actcgctttc gctgcggctc cgcatcttct gcttaacctt gcacgggatc gtaactcgcc 2637061 ggttcattct acaaaaggca cgccatcacc cgttaacggg ctctgactac ttgtaggcac 2637121 acggtttcag gatctctttc actccccttc cggggtgctt ttcacctttc cctcacggta 2637181 ctggttcact atcggtcact agggagtatt tagccttggg agatggtcct cccggattcc 2637241 gacggaattt cacgtgttcc gccgtactca ggatccactc aggagagaac gaagttttga 2637301 ctacagggct gttacctcct atggcgggcc tttccagacc tcttcatcta cctcgttctt 2637361 ttgtaactcc gtacagagtg tcctacaacc ccaagaggca agcctcttgg tttgggctga 2637421 tcccgtttcg ctcgccgcta ctcagggaat cgcatttgct ttctcttcct ccgggtactt 2637481 agatgtttca gttccccggg tctgccttct catatcctat gaattcagat atggatacca 2637541 ctccattacg agtggtgggt ttccccattc ggaaatctcc ggatcaaagc ttgcttacag 2637601 ctccccgaag catatcggtg ttcgtcccgt ccttcatcgg ctcctagtgc caaggcatcc 2637661 accgtgcgcc ctttctaact taaccgttaa aaagaatcac tatgtgatat cttgtgttac 2637721 taattgaatg tgatgtctac tgttatctag ttttcaaaga acacgtttcg aaggaatgat 2637781 ccttcaaaac taaacaagac agggaacgtt ctgtttataa gaccttgggt cttatattcc 2637841 gtataatatc cttagaaagg aggtgatcca gccgcacctt ccgatacggc taccttgtta 2637901 cgacttcacc ccaatcatct gtcccacctt cggcggctgg ctcctaaaag gttacctcac 2637961 cgacttcggg tgttacaaac tctcgtggtg tgacgggcgg tgtgtacaag gcccgggaac 2638021 gtattcaccg cggcatgctg atccgcgatt actagcgatt ccagcttcac gcagtcgagt 2638081 tgcagactgc gatccgaact gagaacagat ttgtgggatt ggcttaacct cgcggtttcg 2638141 ctgccctttg ttctgtccat tgtagcacgt gtgtagccca ggtcataagg ggcatgatga 2638201 tttgacgtca tccccacctt cctccggttt gtcaccggca gtcaccttag agtgcccaac 2638261 tgaatgctgg caactaagat caagggttgc gctcgttgcg ggacttaacc caacatctca 2638321 cgacacgagc tgacgacaac catgcaccac ctgtcactct gcccccgaag gggacgtcct 2638381 atctctagga ttgtcagagg atgtcaagac ctggtaaggt tcttcgcgtt gcttcgaatt 2638441 aaaccacatg ctccaccgct tgtgcgggcc cccgtcaatt cctttgagtt tcagtcttgc 2638501 gaccgtactc cccaggcgga gtgcttaatg cgttagctgc agcactaagg ggcggaaacc 2638561 ccctaacact tagcactcat cgtttacggc gtggactacc agggtatcta atcctgttcg 2638621 ctccccacgc tttcgctcct cagcgtcagt tacagaccag agagtcgcct tcgccactgg 2638681 tgttcctcca catctctacg catttcaccg ctacacgtgg aattccactc tcctcttctg 2638741 cactcaagtt ccccagtttc caatgaccct ccccggttga gccgggggct ttcacatcag 2638801 acttaagaaa ccgcctgcga gccctttacg cccaataatt ccggaaaacg cttgccacct 2638861 acgtattacc gcggctgctg gcacgtagtt agccgtggct ttctggttag gtaccgtcaa 2638921 ggtaccgccc tgttcgaacg gtacttgttc ttccctaaca acagagcttt acgatccgaa 2638981 aaccttcatc actcacgcgg cgttgctccg tcagactttc gtccattgcg gaagattccc 2639041 tactgctgcc tcccgtagga gtctgggccg tgtctcagtc ccagtgtggc cgatcaccct 2639101 ctcaggtcgg ctacgcatcg ttgccttggt gagccgttac ctcaccaact agctaatgcg 2639161 ccgcgggtcc atctgtaagt ggtagccgaa gccacctttt atgtttgaac catgcggttc 2639221 aaacaaccat ccggtattag ccccggtttc ccggagttat cccagtctta caggcaggtt 2639281 acccacgtgt tactcacccg tccgccgcta acatcaggga gcaagctccc acctgtccgc 2639341 tcgacttgca tgtattaggc acgccgccag cgttcgtcct gagccaggat caaactctcc 2639401 gataaatgga tcacaggtta agttcaccgc atcctgcggc gacacctgtg tgacctgcgt 2639461 cgtgcaggcc ctagtttgac tgactacgca catcgcagtg cgatttttaa aaactgaatt 2639521 aacaggtacg ttttgtcttg tttagttttc aaagatcatt tcgttacttc tcaatgaagc 2639581 agctttacta atataacatt cagcttcttt tttgtcaaca acttttttca agttgttttg 2639641 aagcatctag tttgtgtccg ctgtgcatca gcgacgttta ataatataac acctgtattt 2639701 atttattgca atagtttttt aaaaaaaatc tataaaacaa ataaactata atcctcgcca 2639761 tgatttctaa agcgtgtgta tcatataagt ttcttaaaag aacatataca tcagtcatgt 2639821 gatcttgttg tttttttcgt tttcttgtat agtagaaacg aactaaatac tgatgaccac 2639881 aaggggagca ttaaagctga gagtgagcgg tttcgttctg accctttgaa cctgttagtt 2639941 aacgctggcg tagggatgtg gcaaagtcaa atgaattgca gatcgtaaag cagtgcgtgg 2640001 aacttttctc atccttccgc gtgctgcttt tttgttgtcc ttttggttgt ctgtcaatgg 2640061 aaggagatag atatgaatca atctaagcaa ctggttcgcc ttattgaaat tgccattatg 2640121 acagcggcag ccgttatttt agacattgtc tcaggaatgt ttcttagcat gcctcaagga 2640181 ggctcggtct ccatcatgat gattccgatc tttttaattt cgtttcgctg gggtgtcaaa 2640241 gcaggtctta ctacaggttt gttgacaggt ctagtacaaa tagcaatcgg aaacttgttt 2640301 gctcaacatc ctgtacagct attgttagat tacattgtcg ctttcgcagc aatcggcata 2640361 agcggctgtt tcgcttcttc tgtccgtaaa gccgctgtat caaaaacaaa agggaaattg 2640421 attgtttcag tggtcagcgc agtttttatc ggcagtttgc tgcgctatgc cgcgcatgtc 2640481 atttcaggag ctgtgttttt cggcagcttt gctccaaaag gaacaccggt atggatttat 2640541 tctttaactt ataatgcgac ttacatggtt ccttcattca ttatttgtgc aattgtccta 2640601 tgtttattat ttatgacagc accccgtctg cttaaaagtg acaaagcgta aaagtaacaa 2640661 tcccccagcg aattccgctg ggggattttt cgttatctgt taagaagtgt ttttaaagct 2640721 gaaagatccg gccagccaag acctacttct ttcagcctta ctccggcaat ttcaaagttg 2640781 tcctccgcta ctctttcagg tgaataggcc tgataaaata taatcgaggg attctgctca 2640841 ataacccaaa caaacatact tgaaaaacca tgttgaagca aaaactccgc tccttttgct 2640901 aagagcgccc tgcctgcacc ttgccgctgg cgctcttcca gaagataaat agcgtataac 2640961 tcgccgtcat agccttcttg ttcagagcga ataggtccaa atgaagcaaa gccgaatact 2641021 gaaccctttt cgtcctgagc aacaaatact ccctttaacg agcgactttt ccatttgtct 2641081 tcaaattcct tatagttcag gctgtttaaa taatcaatcg ggataatttc gtggtatgtt 2641141 gtcctccagc tgtctacatg cacttttgca atgtccttta tatcctctaa cttcgcttca 2641201 cgtacagtta ccatacggtt ctgccctttc cttactctga tttttggatc gttttggctt 2641261 ctttgatttc atttgttaat tcattaatgc tttgttttac gtttcctttt cctgaaaagt 2641321 tctcaagcat ttcttttaca tcaattcctg aggatgcttt taaactttct tgcagacttg 2641381 acattaagtt cgtcgcatag ctggttactt tgtttgctcc gcttgattca ccgcttcctc 2641441 ctgtatcgac aacggtgatt ttatcaatat ttgaaagagg tgccgctgct tgtttcgcgt 2641501 attccggaag cattttgaca atcatatcga aaatcgccgc ctgcccgtac tgttcaaagg 2641561 cggccgcaat tttctctttt gcttccgctt ctgcaagacc tttcaggcgg ataacctctg 2641621 cttctgtctc tcctttcgct ttttccgctt ctgcttttgc tagcccgtca attcttactt 2641681 tttccgcctc agcctttgcc attgcttcaa tactgtactt cttggcatcg gcttccgcga 2641741 gctgtttggc tttctcagct gctgcggact gctcaacaga ataacggtct gcatcggctt 2641801 ttttctttac ctctgagtcg tattgacgtt cacggcgaag aatttctttt tcttctagtt 2641861 ctatttgttt ttggcgttcg ataattttaa cctgcatttc ctgctctgtg acttgctggc 2641921 gcgctcgggc agtctctaaa tcatatgctt ggtcggcatt cgcttttgcc gtatcttgtt 2641981 ctctgcggaa ttcagccatt ttgagctgat tgattttttc agcttcagcg atttccgtcg 2642041 cccgttcaag ttctgatttt tttgcgtctt tatcggcttc tgcccgctta attcgggttt 2642101 ctttatcagc ctctgctgtt gcgatatcag catcgcgttt tacttgggca attctcggtt 2642161 tccctaatga ttcaagataa ccgtttttat cacgaacatc tttaatggta aacgagacga 2642221 ttacaagtcc cattttcgcg agatcctgtg aagcgacacg ctgcacctct tgagagaatt 2642281 tttctctgtt tttatagatt tcttctactg tcattgagcc gagaatggaa cgaaggtggc 2642341 cttctaaaac ctcccgcgct tcctgctcac ggtcgtcttt tgatttccct aaaaattgtt 2642401 cggccgctgt agcgatttct cctatagaac cgccgatttt aataatcgca gttccatcgg 2642461 ccattactgg cactccttgt tctgtataga cttcaggtgt cgaaacatcg agtttgcttg 2642521 ataataggct tagcggctct gcctgctgga agacgggaag gacaaaggtt cctccgccgc 2642581 ggacgatttt aatacggttg ccgccttcat cgacatgaac atttttatta cccagatagc 2642641 tccctgttac aattaacgct tcatcaggcc ctgctgtacg atacttcgta ataaacacag 2642701 ctattagtgc aattaataaa aagaatacaa ctccgatgat cattataatc ggcattgtca 2642761 tatcaaattc ctccttttat gttaaatggg ttcatgcgga gtaaccgaaa gaactccgtt 2642821 gttaatatct acgactaaca ccgttgtccc gtaactgatc tgctgattat caaaactgac 2642881 cgctgacttt gaaatggtcc cgcctatccc ttctatgacc acttcaccaa acccgtcaac 2642941 cggcacagct gtaatcactt taccgagtct tcctctgaga tcatcttctc tatatgccaa 2643001 tgattcttct gcagatgata atggcaccag tacaaagatg tgaagcaata ccaccagcat 2643061 gatcgaaagg atgcaagata aaagcgcaat cagcaagctt gacagaggca atacaagttc 2643121 acctatatat ccgcccgctg aaaaacatgt aaaaaatgag agcactaatg tcggattaag 2643181 aaacggaatg ccttctgaca gccctgaaaa tacatctccg aaaaacagga ataacagcgt 2643241 aaggctgccc gcaataataa gcgtataaag atacattgtt tgtataggta ctccaaataa 2643301 ctccaacttc ctcatccttt cttcatcaat gcattgatga acggctgccg ttaccattta 2643361 tacgagacac ctcgggaaaa gtttcaaaat tttaagacaa ataacccatt tgaagtgctt 2643421 tataaatgat aattgcttat atatatggta atgtcatttt aggaggagat atgatgagta 2643481 tctttaatga agccagatta gaaacgtgga acgaattgaa aggactttct gacgaaaagc 2643541 tgaatcaaaa gccttctgct gaagaatgga gcatacggga agttcttgac catttgaaaa 2643601 aaatcgatat gaccgcacaa aaaatgttga aggaacgtgt aaaggacgct ccgattaaag 2643661 aaattgaaga aaaaccgctt gaagtagcac aggacagaaa taataaacgg aaagccccga 2643721 gtcatcttga gcctgcgcat gattttattt caggcagcca aatgaaacgt gagcttgatg 2643781 tggtaagaga gcagctgact gctgcgattg cctctctgaa agaagaagat tttgaaagag 2643841 tgcttccgca tcctgtgttt caagagctga ctgtcagaca gtggatcgat tttatcggcc 2643901 atcatgaaaa acggcacctc agccaaatga aagaaattaa agaaaagata gaaagggcct 2643961 gatttaatca gaccctttct gcttttcgtt tgacttttcg ctgataggaa tgaacttcta 2644021 tttcatcacc tgtgtaaaca gcaccaggtc tctccacaat acagacaatc cctctaatgc 2644081 ccagtgcgtg gcggacgaaa gccgacgcca gcttcggttg gtccggataa taagactgaa 2644141 tgacttctcc cggctggata cacggatcat tttcgccctc acacagcaga gccgctccgc 2644201 tcggaaaaat aatccggctt ccttctttta atgaagtaag atctggcata ccgctgactg 2644261 ccacattcgc cccgagccat tccggcaaaa ttctcggcac tcccattttt aaagcgattt 2644321 cgttgcattc ctctattgaa acaattgaaa tttgtctgcg gttgaaaatt tcagtccctc 2644381 ttgaaaacat tggttctctg gctcccgctt ttttggtcag gccaaaatgc aagtcgccgg 2644441 ggatgccgcc ataatcaaaa tcaagcttgt ccatttgctt tgttacgaag ctttttgtat 2644501 ctgcgatata taagccttcc gcttttgcag tcatacgctt ccacatcagc tggcaccttc 2644561 cttcttatct aaaatttcca cctatgcttc attatcccaa aaaatcccgc tctgtaaagg 2644621 agcgggattt tgattatacc gttttaggcg taaggttaaa gcagcgtttg tagatccagt 2644681 tgtatgcttt ttcatttaaa tctctagggt ttccgaaggt ttgcggatct ttcattgctt 2644741 ctttagacaa gcgttcgatc atatcaggtg atactccctg ctcttctaaa gtcggcactt 2644801 ctaaatcttc gaccagatca tacatccaat tgacagatgc tttcgcagct tcttctgttg 2644861 tcatcttgct tgtatcaata ccgaacgctt tcgcaatacg cgcaaacttc tcaggatagc 2644921 ccttccagtt gtattccatg acagggccca tcatcgccgc tacacattgg ccgtgagcga 2644981 ctgggataat accgccaagc gtttggctca tcgcatgagc agcgcccgct gattcacttc 2645041 cgtaagaaag accggcaagc atcgcagcct gcgccattcc gtaccttgct tccagatcct 2645101 ctccatcagc aaatgccctc ttgatgtaat gagcggcata ctcaatcgcc attaaggcaa 2645161 ccgcatccgt gattggctgt gcaaatttca ttgtatagca ctcaatggca tgggcgagcg 2645221 catcaattcc cgtcatagct gttacatgcg gaggcattga aacatgaagc tcaggatcaa 2645281 tgattgtcaa gtgcgctgca atcagcggac cgcccgtgtt gaatttgaat tctctttctt 2645341 catctgtgat aaccgcccat tgggttactt ctgatccggt tccagctgta gtgggaattg 2645401 tcgtcagcgg aggaatgcgg ttttccagcg gttttttccc atctgccgct tcataatcaa 2645461 gcacgcttcc ttcgtgagtc gcttctactc cgattgcttt tgctgtatcc atggagcttc 2645521 cgcctccgac tgccaccaaa ccattacagt tctctttttt gtaaagctca gatccttcat 2645581 tcaccagacg gacaggcggg tttggctcaa ctttattaaa gagtaccact tcaatgcctg 2645641 cttctttaag tgattcgatt acgggatcag caacaccggc tttataaatc ccagggtctg 2645701 tgacaaggag cgcttttgaa acgcccagtg cagctacttc ctcacccgta tgcttgatgg 2645761 ctccgattcc atgcttaatc acagtcggaa tttcaaatgt gtggaatttc tgcatgcttt 2645821 ctaccttcat atttaatgtc atcatcaatc tccccctctt atgaattaaa ccagttaacc 2645881 gctgccggtt ttgtattgcg gtatacatgt ttgacttctg tgtattcttc aaggcctatt 2645941 tttccaagct cgcgtccgaa cccggattgc ttatatccgc cccatggcgc ttgtgcaaag 2646001 tacggatgaa aatcgttgat ccaaacggtt cccattctca agcgggctgc tacccgttcg 2646061 cacttttcaa tgtcttttga ccataccgct ccagccaagc catagatggt atcattcgca 2646121 agctcgatta cctcttcttc agagctgaag gtttcgactg tcaatacagg accgaaaacc 2646181 tcttcctgaa cgattctcat gtcagaatta cagtttgaga aaatagtagg ttcatagaaa 2646241 aagccgtttt gaagctcagg atcttccggg cgtttgcctc ctgtctccag cttcgcgcct 2646301 tcctctattc cgatctctac atatttttct acctttgccc tgtgctccgc cgaaataagc 2646361 ggaccgcttt ctgtctcagc atgaaaaccg tttccgagtt ttatgcgttt tgcccgtttg 2646421 accagctccg ccaaaaattg atcatgaatg gcatcctcaa caagcaagcg ggaacctgca 2646481 gagcatactt ggccggcgtg gaaaaataca gcgtttaagg cctgatcaac cgcaacttct 2646541 aaatccgcgt ccttgaaaac aatatttggg tttttcccgc caagttcaag ggcgattttt 2646601 ttgacgtttc cgcttgccgc ccgcatgatt tttttgcctg tttcaattcc gcccgtaaat 2646661 gaaatcaaat cgacgtcttt gtttacggca agctcgtcgc ccactgtggc tcccggtcca 2646721 agaacaagat ttgcgacacc ttttggaaca ccggcttctt ccatcagctt aaagactttg 2646781 attgtcgtca gcggcgtaat ctcactcggc ttcatgacga ttgtgtttcc tgcggccagt 2646841 gcaggggcga ttttccagct cgcttgaagg agcggataat tccatggagt gatctggccg 2646901 caaaccccga ttggctccct aataattttg ctttctgaat caggaatcgg agatgaaatg 2646961 atctctccgc catctttgtc tgccaagccg gcgtaatatt gaaaaacatt ggcgatatcg 2647021 tccatatcgg ccttgctttc ttcgagtgtt tttcctgtat caagagattc aagctcagcc 2647081 agctcctcaa gatcgcgtct gattaattcc gcaattttca gaacaatttt tccgcgttca 2647141 agcccggata gcgatgacca ttctcctttg tcaaatgctc tacgtgcggc tgcgattgct 2647201 ttgatggcgt cctctcgccc tccctcgctt acagttgcaa tttcttcttg attaaatggg 2647261 ttgataatac tgcggatctg ttctttttcg gcactgatcc attctccgtc aatgaataat 2647321 gtttgactca tataagcctc cttgacgtaa ataaagtttg ttaaataaaa atttaatgtt 2647381 tttaacaacc ttaatctaac atatggtttt taaactgtca aagtcccatt ttgatttttc 2647441 tttttgactt ttcctcatgt ttcgttaaga taaagaacat aaagaaataa cttaacgaat 2647501 ttaattttct aaaggaaaag agggtcagta tggatgaaaa tccagaattt gcagctatag 2647561 aacaggctcg ggatcttgtt attgactcca ttgctgaaac gatggatctt tacggaatta 2647621 cccgcagtgt cgggatttta tatgggacga tgtatatgag ggatgagatg acgcttgacg 2647681 aaatgcgtga ggagttgcaa atgagcaaac caagcatgag cactggcgtc aaaaagcttc 2647741 aagacttaaa tgtagtgaaa aaaacatttc accggggcat ccgcaagcat acatttgtgg 2647801 ctgagaagga tttctttaaa tttttcacaa atttctttcc acctaaatgg gagcgggagg 2647861 ttcaagtgaa tgtaacagcg atcgaggaag ctcaagctga tttacaaaag gttttatgca 2647921 aggaagatct cgatgaggat atcaaaaatg aagcactgca gttatatgat cagctggaaa 2647981 gctctaaagc ttactatgac tggctgaaac ggcttgctga atcggtgcag accggagaaa 2648041 tttttaaatt tataccggtc gaaacaaagt aaagcagaaa acgcctggga aactaggcgt 2648101 ttttttgatg taactactac aaatttgaaa aatacgggaa aaacacccca tttacttcca 2648161 aaatatttga tggtaatttt atgtaggtaa aatttgtatt tggcctttca gaggaggtga 2648221 aaagcgggca ggcctgttta atttatcatt ttttaggggg aattttgtta tgaaacgcaa 2648281 attattatct tctttggcaa ttagtgcatt aagtctcggg ttactcgttt ctgcacctac 2648341 agcttctttc gcggctgaat ctacatcaac taaagctcat actgaatcca ctatgagaac 2648401 acagtctaca gcttcattgt tcgcaacaat cactggcgcc agcaaaacgg aatggtcttt 2648461 ctcagatatc gaattgactt accgtccaaa cacgcttctc agccttggcg ttatggagtt 2648521 tacattgcca agcggattta ctgcaaacac gaaagacaca ttgaacggaa atgccttgcg 2648581 tacaacacag atcctcaata acgggaaaac agtaagagtt cctttggcac ttgatttgtt 2648641 aggagctggc gaattcaaat taaaactgaa taacaaaaca cttcctgccg ctggtacata 2648701 tactttccgt gcggagaata aatcattaag catcggaaat aaattttacg cagaagccag 2648761 cattgacgtg gctaagcgca gcactcctcc gactcagcct tgcggttgca actaatgtaa 2648821 aagaccggtt aacgccggtc ttttttgcgt tttaccctcc cctttttctc taatccccgt 2648881 tatctttttt ctggtttaaa atttaaattg acaaacacta gaaacaggag taaattcttg 2648941 agtgttcaat ttcatacagt ctcttttacc gcttaatcaa acacgaacgg gggaaccaac 2649001 gattggctgt tttattaaca gccttggggt gaatcttact aagtaagagg gggtactctg 2649061 aatccctaat ccgacagcta acctcgtagg cgtatacaga gaggaggtct attatcggcc 2649121 attctttgca atggtctttt ttgtttcaaa aacgttaatt cactaaggga gatatgaaca 2649181 ttgggaagaa ttaaaaataa gcaatttgcc gtgatcgggc tgggccggtt tggcggcagc 2649241 atttgtaaag aacttcatag aatggggcat gaggtccttg cggttgatat caacgaagaa 2649301 aaggtcaatg catatgcttc ttacgccact catgcggtaa ttgccaacgc caccgaagaa 2649361 aacgaattgc tttcattagg aatacgcaat tttgaatatg tgattgttgc catcggagca 2649421 aatattcaag cgagtacgct gaccacccta ttattaaagg agcttgatat tccaaatatt 2649481 tgggtgaagg ctcaaaacta ttatcatcac aaggtgcttg aaaaaatagg cgctgaccgc 2649541 attattcatc ctgaaaaaga tatgggggtt aaaatcgcac aaagcctttc agacgaaaat 2649601 gttttgaatt acattgatct atctgatgaa tacagtattg tcgagctgct ggctacgcgc 2649661 aagcttgatt caaaatcgat tattgacctg aatgtaagag caaagtacgg ctgcacgatc 2649721 ctggccatta aacatcatgg agatatctgt ctttcccccg cgcctgaaga catcattcgc 2649781 gagcaagatt gcctggtgat catgggccac aaaaaggata ttaaacgttt tgaaaacgaa 2649841 gggatgtaga caaaggtgac acttcaaaag gataaagtga tcaaatgggt tcggtttaca 2649901 ccgcctcaag tgcttgccat tggttttttc cttaccatta tcatcggggc tgtcctatta 2649961 atgcttccga tttccactac gaagccattg tcatggatag atgccctttt tactgcggct 2650021 tccgctacaa ctgttacagg gcttgctgtt gtcgataccg gcactcaatt tacggtattc 2650081 gggcaaacag taattatggg gctgattcag attggcgggc ttggatttat gacatttgcg 2650141 gtcttgatcg tcatgatatt aggaaaaaaa atcggcttaa aagaacgaat gctcgtccag 2650201 gaagccttaa accagccgac aatcggcggt gtcattggcc ttgtcaaagt cctgtttctg 2650261 ttttcgatca gtattgaatt gatagcagca ctcattttat ccatccggct tgtacctcaa 2650321 tacggctggt catccggctt gtttgcaagt ttgtttcacg caatatctgc ttttaacaat 2650381 gccgggtttt cgttgtggcc tgataatttg atgagctacg ttggcgatcc tacagtgaac 2650441 ctcgtgatta ctttcttatt tattacagga gggatcggat ttacggttct gtttgatgtg 2650501 atgaaaaatc ggcgttttaa aactttttct ttacatacaa agctcatgct tacaggaacg 2650561 ctgatgttga atgcgatcgc tatgcttacg gtctttattt tagaatacag caaccccggc 2650621 acgctcggcc acctgcatat agtggataaa ctgtgggcct cctattttca ggcagtgacg 2650681 ccgagaaccg cagggttcaa ttctctagat tttggaagca tgagagaagg aacaattgta 2650741 tttactttat tattgatgtt tatcggagca ggaagcgcat caacggcgag cggcattaag 2650801 ctgactacgt tcatcgtgat tttaacatct gttattgctt acttgagagg taaaaaagaa 2650861 acggttattt tccgccgttc catcaaatat ccgattatca ttaaagcttt agctgtgagc 2650921 gtcaccagtt tgttcatcgt gtttttaggg attttcgccc tgacgatcac agaacaagcg 2650981 ccatttcttc aaattgtgtt tgaaaccttt tccgcattcg gaactgtcgg ccttacgatg 2651041 gggcttactc ctgaactgac aacagctggc aagtgtatca tcattgtcat catgtttatc 2651101 ggaagaattg gtcctttaac gttcgtgttt tcattcgcaa aaacagagca atcaaatatc 2651161 cgttatcctg atggcgaagt gtttacaggg tgatatcaaa aaaatccggc gtgcagtcgc 2651221 cggatttttt atgattcgat atgagattga ttttgtcttt tttcctgttc cgcgatgatt 2651281 tcgttatcct ccgcgttatc acgggtcact ttttgcgtaa gaatcgcacc aactgctaca 2651341 agtatcataa cagcgatgta ataacctttt tcattgagtt ccagattatc agcattatag 2651401 agtccgatac taaacaaaaa tactcccgca aaaaaagtaa aataagctag tactgtaaag 2651461 gcaaccgtgt ttctgcgtct atatttctgc acctttgttc cctcccgaaa gcatagttaa 2651521 aaagtgataa cttccgtgga atattatacc tcaaattccc cggaatggaa caaagaatta 2651581 aaaataccag taaaaagggc ttaggttgcc tcctttattt caacagctga atcatcaatc 2651641 cagccgataa gtttatcatt gatttggaat tggtaccata cagactggcc tttctgtttt 2651701 ttagacacaa cctttatgtc tttgccgacg taagattggg cagaggtaag ccttatggac 2651761 cgatcatcag tagaaggctt ggaccatacg tcttgaacgg cactgtcttt aatagaggcg 2651821 tttaaatcca cagatttgag ggatggattt acctcatcgt actcatctaa atcgtatttt 2651881 tccacaatag cgctgatttt gtcagcgtag tcagggtctg tagcatatcc tgatgtttgc 2651941 agggcggttg ccgcttcctt ataattccct gcctcaagca ccggtttata cttcttttta 2652001 ttccacgatg tgccacggac gaacaattgg gcgtgatcat ccatagattc aaaaaacgtg 2652061 ctgtattttc gaaacttcgc gcgaatggtt tttcttttcc ctttttcaac ttcgtccgtt 2652121 tccatcgtga catgatggcc tttataattc ccttttacgc caaaaaggtt gttggcctta 2652181 gcagccagtt cactgttccc ccagtccgat tcgagaatgg cctgagcaat tgtgatgctg 2652241 gggagaacat ggtatttttc atacaaaatt tgggcatgtc cggacagact gtctataaat 2652301 acttgctgtt catcgatttc ttcagtttct ttggatattt caatcggttt tgataaagtt 2652361 gtcgctaaaa caaacagagc tagcggaatc gatacaagga aaaatagtga aatcaagagt 2652421 ttacgttttt taagtttttt acgggccatg aaaaccttcc ttcgaattaa aagattacga 2652481 atgtaaaaga atctaccttt tagaatttta cttgcacttc taatattttt caattcttta 2652541 gggataaagt tgggaaaaga ttgcaaaata aaaacctttt cgctcaatga aaaggttttt 2652601 accatgtttc tatttttgta aatttctgag tgcattccga tattccgtat catttattac 2652661 tttatatgat ttgacagttg ccttcgacaa accttgtgct gagacggccg gtttttccgg 2652721 agctgttttc gctttatcat gtggtttatg tgccagcttg tgccccattc cagtggcatt 2652781 catacaaaat gacaggcaga cgagcagcac gctaaggata aaagaaatga agaagagatc 2652841 atgataagca gtcatcatag aatcctgtac cgaaccgctt tgtctggcag catctttttt 2652901 cgtgaaaaag ccgatgagaa tgggaactcc catatagaca aacaatctta aaaactgaac 2652961 agctgtcatt ctcttgacca aatcaggcag cgggcctccc atggcagctc ccatcagccc 2653021 tgcggcgact gtcaggcctg ttcccgctgc aagcatgata aacagtgccg cgaacatata 2653081 aagagatgat cgatcctgta tatgcagcca ttgaaaattc acaaaaacga gaatgagtcc 2653141 gccgataata ccgagcatcc ctggtccgac tttatcgtat aacagagcgc tcaaaatggc 2653201 cgcgatcgcc actccgatta aaagagtcaa gcttaaaaga atgagatgct cctgagaaat 2653261 atcatacatt tgacggagca agccttgaaa agcagaaagg ctgacagcta ccgttatcgt 2653321 ccctgcagct atgatcaata agccgagcac cggttttggc agcagcatca gtttaataga 2653381 tatgaagggg tttttcactt tatattccac aatcaataga ccaatgagca aacataacgt 2653441 caccccgaaa ccaatccata cataacccga tgacagcccc catttttgca gaaaaatgaa 2653501 tgaaaccgct gaggctgcgg caaggaagac agataaaaga attcccgcac gatcaagcgg 2653561 ctgttcttga tccgccgctc cgtgatgctc atcatgaaga aagaaatagc tcaccgcgac 2653621 accgatcagg gacaaggtgc caaagatgaa aaacagccat ctccaatgcc cgcagcttgt 2653681 tgcaatggtt cccaggattg taccgatgat aacagaacca tagaatcccc cgatcagcac 2653741 aagcagtgca tagttcctgc gttcaatcgg gaatgacagt acaagcattg gaatcataat 2653801 catcagcatg acgcctgttg ccgccccttg taaaaagcgc cctgccgcca tcaatgcaat 2653861 atcgcctgaa catgcgatga gcagtgagcc tagtataaag acaggtaatg aagccagata 2653921 gacgggacga gcaccgaatt ttttcctcag cagcggtcct gccggaacta acaaggcaaa 2653981 ggccatattg ccgatcaata tcggatttac tgatgtaaag acacttgttc caaccgtttt 2654041 ctgaacaagg ccttgaactg acgacaatgc cgtgttagac atcaatcccg gcccgaccgc 2654101 taagacggcg agcaaagaaa tcacccaata gtgttttgtc ttcatgttgt catcccttcc 2654161 tatatgaata catgcgaaac acatcatttt ttgaaaacaa aagaagctaa tagattttgc 2654221 ataccattag ctttcattct aatattctcc ctttcagggg aaatgatatt attttattat 2654281 aattatgtga atgaatgagc atataatcaa atattatttc aaatcgattg tgttttgtca 2654341 atggagtaaa tttcaagcac aacatagaaa gcttgaaagc ttttccccga tattgtgtct 2654401 agaactgcac ttatgaatcc ctgctcgttc cctcaagcga attaaagcag gccgttttaa 2654461 tcctttcaat ccactattcc aactaataaa ctcaaataag ttggtgataa gacaacattt 2654521 tacccccaca tttttttgtg ttcactgggc gtttgccgcc tctaaattgt atatgggtaa 2654581 ataccatgaa ttaacctatg aaataccaat gtaagggagg caaaaacgaa tggaactgta 2654641 tgagtgtatc caagacattt ttggcggctt gaaaaatcca tcggttaaag atttagcaac 2654701 gtctttaaaa caaattccaa acgcagcaaa attgagtcaa ccgtatatta aggaaccaga 2654761 ccagtacgct tacggccgaa atgccatcta tcgaaataat gaattggaaa ttatcgtgat 2654821 taacattccg ccaaacaagg agacaacagt acacgatcat ggtcaatcca ttggttgtgc 2654881 aatggtgtta gaaggaaagc ttcttaattc tatttatcgt tcaaccggcg aacacgcaga 2654941 actctccaat tcatactttg tccacgaagg agaatgcctt atttcaacca aaggtttaat 2655001 tcacaaaatg tccaatccaa catctgaacg aatggtgtct cttcatgtct actcccctcc 2655061 tttggaagac atgacggtct ttgaggaaca aaaggaggta ttggaaaatt catgattgac 2655121 agataaactg ctcactttga cttcactcaa ctggaggatt cagagaatga aaccttttcc 2655181 tcaaaacaaa aaaaccctta tcgaataagg gtttaaaggt atggagccaa gggggctcga 2655241 acccctgacc tctacgctgc cagcgtagcg ctctcccagc tgagctatgg ccccgtatgt 2655301 aacgtcatgt ttattataga tgattttatt ttgaaaaaca agctgtttcc tcttgaattg 2655361 acagaaaaaa taaggctcgg aaaagagcct tatttttcga cttacatcat gatcaaaagt 2655421 aaaatcacac cgagaataat tcgatagatt gcaaatggga caagtttgat tttgttaatc 2655481 agccttaaga agaaacggac gacaaacagt gcgaccacaa aggcacagat aaagccgacg 2655541 atgaaaaacg gcatcagatc cgaacttaag ctgtcccaat gcttcacgag gcttagaaag 2655601 ctggctccca tcatgatcgg catcgccata ataaacgtaa agtcggctgc agctcggtgg 2655661 tttaatccga gaataacacc gccggaaatg gttgaacccg aacgcgagaa accaggccaa 2655721 agggaaagac attggaataa gccgacggct atcgcctgtt tataggaaat gcggtcgagt 2655781 gtgtctgtcg ctgttttccg tttattgacc cagtcagcaa aaagcatgag gattgccccg 2655841 gcaattaaac cgatggccac agttttaacg gaaaataaat attcatcaat gtaatcttca 2655901 aacaaaaagc cgagaacagc tgcaggcacg agtccgacgg caatttgggc aatgcttaat 2655961 ttatgtccct gctcctggtc gcttgtaata ttttttttca agcccagtaa atttaaaatt 2656021 cggtctttaa acacgatagc tactgctaaa atggagccta gctgaataac caccttgaat 2656081 gagttagcag cttcttctga catcagatta cttgatttta gccagatgtc gtctactatg 2656141 atcatatgtc ctgtcgaaga aaccggcgcg tactctgtta atccttctac gattcctaaa 2656201 atggcggcta caaacaattc ccatagagtc atgattttga ttctccccat tagacattta 2656261 tttttttaca taacgggagc ttcccataaa tggaaagccc gtcttatata actataaacg 2656321 aaaatcacac tttatgcccc ggcgtatttt catttttttc ttcatcgtat aaatgtgact 2656381 gcattttaaa ccagtcaaat aaatgtgtcg taatgacttt ggcaaccgca tagccgggaa 2656441 tcgcaagaat gattccaaca acgccaaaca gcttgccggc tgttaacagc agaaaaataa 2656501 tcgtaatcgg atggatgtga aggttttttc ccataatttg cggagagatc agcttccctt 2656561 caatcagctg aacaatcgtc caaacgatca ccagcttaag cagcatgagc ggcgatgtca 2656621 ctatggcaat gataatcgca ggcgtaatgg caatcgttgg ccctaaatat ggaacgatgc 2656681 ttgtgcaagc cgcaatgact gcaagcaatg aagcataatc cagcccgata atcaaataac 2656741 cgataaacag caaaaacccg atacagaagc tgacaatgat ctggcctctg atataagagc 2656801 ttaaccgatg attcatttcg cttaagactg tatatgtctg ttctttcaat cgagtcggca 2656861 caaacttcag tatgtagacc ggtaattttc ttccgtcttt tagcaaataa aatagaataa 2656921 acggaaccgt gacgatcgaa atgataatct cagtcagtgc gccgataaaa ttcccaacac 2656981 cggtaaaggt gctgttcacg atcgtcgctg cctgatccga aacctttgta gcaagatcag 2657041 atatattaat gttcatcgtt tgctgggcct gattgacgaa gttgctgcca atcagctgtt 2657101 tcgtctgatt ttctacgacg tccacatatc tcgggatatt gtcaatcaaa ctcataattt 2657161 gttcttttaa gaagggaatg atcgacacga tcgtgatcgt gatcagcccg ataaccaata 2657221 ggtatagcag caatatagaa tagattcttc ttattcttct tctctccaga aaatcgacga 2657281 ctgggtttaa cagataaaaa acaatgcctg tcaaaataat cggaagtgat atcgttttga 2657341 gcagaacaat aatcggggtg aaaataaatg atgtttttgt aaatactaga atatttaaac 2657401 caatcagcag cagcacaagc aaaaataaaa caaacttatt atccaagaag aatcgcttga 2657461 atctgccgct ccatgtttgc aacgtctcca ctatcgttcc tccgtcatac atagtttaat 2657521 taaattgtac actatcgtcc ctataatgaa aaataaaaac cgttaattgc tggaaaagct 2657581 ttctcggttt taacattcta tttatatcta tcatgtgatt ttgttctttt taagctataa 2657641 tttagctata tcatgcaaaa ggagcgatac gagtgatacg ttttgcaata ataggaacca 2657701 actggattac agaccgcttt cttgagtcag cagcggatat cgaagatttt cagctgactg 2657761 ctgtttattc aagatcggct gaacgcgctg gcgagtttgc tgctaaacac aacgctgcgc 2657821 atgccttctc agaccttcag gaaatggcgg cgagcgattg ctttgatgcc gtatacatag 2657881 cgagcccgaa cgctcttcac aaggaacaag ccgttctctt tatgaaccat ggcaagcatg 2657941 tgctttgtga gaagccgttt gcttcgaata caaaagaaac agaagagatg atctcagcgg 2658001 ctaaggcaaa cggcgttgtt ctcatggaag caatgaagac cactttcctg ccgaatttca 2658061 aagaactgaa aaaacacctg cataaaatcg gcactgtccg cagatttacc gcaagctact 2658121 gccagtattc ctcacgatat gacgcgttca gaagcggaac tgttttgaat gcgtttcagc 2658181 ctgagctttc caatgggtca ttaatggata ttggcgtcta ttgtatttat ccggctgttg 2658241 tgttgtttgg cgcgccgaag gatgtaaaag caaacggata tgctttatcc tccggagtgg 2658301 acggagaagg aactgtcatt ctgtcttacg acgggttcga agctgttctg atgcattcca 2658361 aaatctctac ttcctatgcc ccggctgaaa tccagggtga agacgggacg attgtaatcg 2658421 atacgattca ccggcctgaa cgtgttgaaa tccgctaccg ggacggccgc cttgaaaaca 2658481 tcgcgatccc tgatcctaaa ccggcgatgt tctatgaagc agaagaattt gtcacgctta 2658541 taaaagagaa taagctggaa tctgaagaaa atacatttga acggtctttg accaccgcaa 2658601 aaattatgga agaagcaaga aagcaaatgg ggattgtata ccctgctgat caagcttaaa 2658661 aaaatccgcc cgcgtgcaaa tgccgcggcg gattttttat tagacaatcg gagaagatgc 2658721 cttccttttt aaaagcacct gttgctcata ttctttgatg tcataaagcc atgcctcttt 2658781 taccggaacg cccatttgct cacagtagga atcccagatg gctccgaaag gatatgtttt 2658841 gaattcctcc atcagggcca gcctttctgt atagcggccc tcttcctgca attgttttaa 2658901 atatccgttc gggagaagca gggcatacaa taaagctttg atcatatttc tcgttccgat 2658961 ggtccaggcg gctacacggt taatgctggc atcgaaaaaa tccagaccga tggctacctt 2659021 ctcaagagca tgatttcgta caatttcaag agcgatttct ctcaattcat catccaaaac 2659081 cactacatgg tcgctatccc aacgaacagg ccgcgatacg tgcaaggcaa gcttgtctgt 2659141 gtaaagcagc atggacgaga tcttgtttga taccgtctca gtcggatgga aatggcctgt 2659201 atcaagtaaa caaagcttat gattcgtcaa agcataagct aaataaaatt catgagatcc 2659261 gacaacatat gattcggagc caagcccgaa cagcttgctc tcgattgaat caagattatg 2659321 ttgttcactg atctcctctg agaagatccg atccagtgat tcttttagtc ttttacgcgg 2659381 tgtcagccta tcactcggga tatccttata gccgtcggga atccaaatat tcgtcaagca 2659441 aggtgttcct aattctttcc cgaagtattc cccgatacgg cggcaagcga tgcaatgcct 2659501 gatccaaaat tctctgatgt ccggatcagg gtgtgaaagg gtgagtccgt cagccgcttt 2659561 ctcatgcgaa aacaaggttg gattaaaatc taaaccgaga ccaaggtttt ttgcccattt 2659621 cacccagttt tcaaaatgct gcggcttcaa ttcgtcacgt tctaccgctt ccctgtttgt 2659681 ttctgcgtat atcgcatgca ggtttacgcg gtgctttcca ggaatgagag aaagagcctt 2659741 ctccaaatct cttcttaatt cttcaggagt ttgcgctttt ccgggataat tgccggtcac 2659801 gtcaattccg cctgaaagct cgcccttatt tacttcaaag ccttcaatgt cgtcaccctg 2659861 ccagcagtgg atcgaaatgg gcacttgctc taattgccga agcgcctctt caacatcaat 2659921 tccccatttt tcatatgcct gttttgcact gtcataattg gcttttatgg tcatacggct 2659981 ctctcccttt atcagttttt caatccaaat aaaaaacttc ctttagatct atcgcaacag 2660041 gactgaaatc cgaatttgtt ttcattaatg gcgccatcga tttccaccat ctttggcaaa 2660101 cttccgtgtc cgccatcttt ctccatttct cttcatcctc tatttctaaa tatgcaaaaa 2660161 gcctgcctgt ttcctcgtct agaaaaatgg aataatggtg tgctccatga gctttgagtg 2660221 cttctgccat ctcaggccaa atgtcatcat gccgctgttt gtattcttcg tacttgtctt 2660281 gatggacaaa catgatactg gcttttcttt tcaaaccttt tcacctcttc atcatttaga 2660341 tagcgctttc aaaacagttt gctgaaatga ctgaatgatc gtgcttctat caatgtcttt 2660401 aggtgtaaac actttgatcg gaaaggaatt tctgacgact tgccgggctt cttttatgtc 2660461 tttgacttct ttggcagcaa tcatttgcat caaaagattt ccggtggcag ttgcctctat 2660521 cggccctgca tataccgctt ttccactcat gtctgccgtt aattgattta agaaatcatt 2660581 ccgggctccg ccgccgatga tatgaaattg ctcgatcggt ttttctgtga ttgtttcgag 2660641 ctctttgatg gctatcgcat agatgatggc taaattgctg tagatgcagc aggcaagttc 2660701 gcctgcagta cggggaatct tttggcgggt ttgtctgcaa taatgttgta tttcctttat 2660761 catgttttct ggattcagga aacgtttatc atttaagttt ataaattgct ggaatggttc 2660821 tgtttttttg gcttcttctg caagctgctg aaaagaataa tctgcttgta gctgctgttt 2660881 gacttcttgt atcacccaca tgccgataat gtttttgaga aagcgaatgg tgttgtttgc 2660941 gccgcgttca tttgtatagt tgttttctaa agcaagatca gttattatcg gtgttttgtt 2661001 ttcaaccccg attaacgacc atgttccgct gctgatatac gcccagccat catttacgcc 2661061 tggcgccgca atgacggccg aggccgtatc atgtgttgcg actgtcatca ccttgcacgc 2661121 cgggagatca taatccggga accactcatt tcttagcttc ccgagttcac accccggttc 2661181 agtgagcggc gcaaattgct gttccagaac agacacggct tcaagcaatt caggatcaag 2661241 atttcccgtt gagacgttta aaagctgtgt tgtggacacg tttgtgattt ccgttacagc 2661301 ttttccggtt aaacaatagc ctaaataatc aggaatcatc ataattttgt ctgtcttttt 2661361 cagcagctca cggtcttctt caaacaattg atagatcgtg ttgaaaggct gaaattgtat 2661421 tcctgttttt tgataaattg cggcttttga gagggtatgt tccagtttgt ctattgtgtg 2661481 atctgttctt ctatcacggt aggagattgc ttcccgcaac cgatcgcctt tttcgtccag 2661541 taagacataa tcgactgccc atgtatcaat gcctacggtg cagtgttcat acccaagcgt 2661601 ctttactttt tgcagtcctt gcaggatttg ttttagcaaa tgatcaatat cccataagca 2661661 atgcccgtct ctttgactga aaccgttagc gaacctgtga atctcttgta tgtcaagctt 2661721 cccttcattc agttcaccta ccatgattct cccgcttgat gcgcctacat caatggcagt 2661781 ataaatcatc ctttcaccct ctcttcgaaa gaggaacagc tgtcaccttc acctttttgt 2661841 cctcaagagc ttttaccgat gccggatcaa gtccagaatc cgtaataagg cggctgacat 2661901 cttgcagcga ggcgatatgt gaaaactcgc ggttccccca tttgcttgaa tcggccatca 2661961 aaatggtctg gtccgacctt tcgatcatcc gttttttgag cagcgcctgc cactcatttg 2662021 aatcactcat cccgttgtgt acgtcaaatc ccttacatga cagaaaggtt ttattgacat 2662081 gataggtctc aagtgaacgc tctgctaacg ggccggcaaa tgataatgat ttttccagca 2662141 aaatgccgcc tgttgaaatg actgatatgt tttctttatt gctgagttca atagctgctt 2662201 tcattgagtt tgtaatcacg gtgagctcaa tgtcagggag tatttttgcc atgtaccaag 2662261 cggttgtgct tgcatcgaga atgattcggt ctccgctttt tacatatttg gccgcttcgt 2662321 gagcgatggc ttttttttcg atgacattcg tgatttcccg ttcagaaaaa tgaatttctg 2662381 attccttctg ctgaatactg accgctcctc cgtggctccg gctcagttta tgttcttttt 2662441 caagcttttc aagatcacgc cgaatggttt cctctgtgac tgaaaaaatg tcacttaatt 2662501 cggaaacgcg gatgcttgaa cgcatattta ctatttccac tattttttgc tgccgttctg 2662561 ctactagcat cggtaacgcc cttcctcata tcgtagtccg tcttatattt ttatcatagc 2662621 atatatctaa cgcgtaaaag cagcagggac gccgccgtct accgtgatca tgcagcccgt 2662681 tgttttttcg gctttggaag aagcgaagaa tgcaatggct tcggcaatat cctccgggta 2662741 aatattgacg agcaatgctg tccgtttccg gtaatgttcc tccagctgat ccggttcaat 2662801 cccgtacgcc gcggctcgtt cctcacgcca gcttgaaccc cagattgccg atccttgaag 2662861 aactgcatca ggcaaaacgg agttgaccct aatgccgaat tctccgcctt ctgctgcgat 2662921 gcatcttgct aaatgggttt caagcgcctt aacagagctg taggcagagg cgttttttcc 2662981 cgcataaact gaatttttcg atccgacaaa taccatgctt ccgcctctat tttgatgttt 2663041 catctgttta aacgcttcac gggctacaag gaaatagcct gttcctaaaa cattcatatt 2663101 aagattccat tcttttagac ttgtttcgtc aaatgggctt gatgtggcca gcccggcatt 2663161 attgacgacg atatcaatgc cgccgtaagc aagcgccgct cgttcaaaag ctgactgtac 2663221 gtcttcctcc tttgtcacat ccattttgac agccattgcc cgtccttttc cgtatgcatc 2663281 gtttatttcc ccggcaattt tctgtgcgcc ttctatattc agatcagcta cgatcacgtg 2663341 ccctccctca gctgcaaatc ggcggcatgc cgcactgccg attccgccgg ctcctccagt 2663401 tatcagcgct acttttcggg aaaattctgc ttccggcggg gccagcgtga gtttatatag 2663461 ttcgagcggc caatattcga catggtagga ctcattttca tgtaaagaaa caaattgccc 2663521 cagagcggtt gctcctttca ttacggcgat ggccctccga tataaagccc cgcttacttt 2663581 agacatcgca taactttttc ctgtattcac cattccgatt ccaggaatca atatcacccg 2663641 cggggcggat tcaaagattt gatccccatc ctgctgattg cgtgtaaagt aagcctgata 2663701 ctctgatgta aaggtctcga ctcctgactt gatcagatct gcaagcttgt gcacatcttg 2663761 agtttccgga ttccaatcaa tgtacagcgg aacccgtttt gtgtgaacaa ggtgatccgg 2663821 gcatgccgca ccgatttgcg aaagtgctgg cgcttggaca ctgtttacaa attccaagac 2663881 atcgtcatga tcatcatagg aaaggatcat tttcttttct tcacttactg ctcctctgat 2663941 cacaggcatg atgcctgcca agatttgttt tcttttatcc tccggcagcg gctgatacct 2664001 tttgcctccg aatacctcat gctgattgat acgatcgtta atatactgct cggcttcttg 2664061 aatgatggat atcgtttttt gataacatgt ttcagacgtc tctccccaag tgactaagcc 2664121 gtgtttctcc attaatacaa gctcggcgtg ggggttgttt gctacgcctt cagcgatcat 2664181 tttagacaaa gtaaatccag gacggacgta tggcacccat acaaaccgat ttccgtaaat 2664241 gtcttcagcg atttgttttc cattatccgc acagcatatg ctgataatcg catctggatg 2664301 ggtatggtca acatgtttgt atggcagaaa agcgtgtaat agcgtttcaa ttgaagggcg 2664361 gggatgtttg ctgtctatca tacaatgaga caggtagtct accatttctt catcgggcat 2664421 ttggtccctt ttaatcagcg ggcggatatc atctaatttc aaaccggaaa agttatgcgc 2664481 tttcattgtt gccaaatccg atccgcttcc ttttacccac atgacttcta tttcacggcc 2664541 tctaaaatcc ttttccgttg ttttcataga tgtattcccc ccgccccagt tgcagacagt 2664601 gcggtctgac ccgatcagat tggacctgta caccaattcc tctacacctt taggtagctg 2664661 tgcagctcgc tctgaatccc atatatgttt caccatattt gatattcctc catacccttt 2664721 tatttgtatc cgttttcatt atatatgatt tctgtttgtt tttgaatcgt ttttgtttat 2664781 ttttgctttt taacaaaaaa agaaagcagc agatatgccg ctttctcgtt tcattatgat 2664841 tctattttaa atttcttcgt aatgtcctga agttcttccg ccatgtttgc caacgtttcc 2664901 gctgaagagc tgatttcttc catggacgca agctgttctt ccgccgaagc tgcgatatcc 2664961 tgaatgcctg ctgagctttc tttcgccact gcagaaatat cttcaacagc acttgacact 2665021 tcctgtgatc cggctgacag ttgttcaacc gtcgcgttca agttttgcaa ttcgccggaa 2665081 atttgggttg tcatctcata gatttgttta aagctttccg ctgtttgatc cgtaatctgc 2665141 aagccttctt tcacttcatg attcacggat tggaacattg aaagtgaggt gctgatttcc 2665201 ctgacaatct cttgaattaa tccttcaatt tccttggcgg agtctgctga ttgtacagca 2665261 agttttctaa cctcttccgc aactactgag aaacctcttc cgtattctcc cgctcttgcc 2665321 gcctcaatcg cagcatttaa tgcaagcagg ttggtttgat cagcaatgcc gttaatcaca 2665381 ttcaagatgc ttgtgatgtc ttgcgatttt gtttcaaggc ccttcacaac cgcttccgct 2665441 ttttgaacgg attggtcaat tgttttcatc tggccgactg tatgctccac cagcttttct 2665501 ccgctgcccg ctgcctcaga ggactgaatc gatgatttcg taatggttga agaggcttga 2665561 gccacttttg aaatcccctc gttcatttga gaaagatgat ttgagcttgt ttccagtttc 2665621 tcgctttgtg cctcgttgcc atctgagaac tgttcgatgg caagtgtaat atgttcagtt 2665681 gccttgcttg tttgggctgc gcttgctgtc agctcctcag aagatgaagc gacgttttct 2665741 acagacgttt gaataacgcc tattacagaa cgcaatgatg cagacatttc attaaagctt 2665801 tcgccaagct ggccaaactc gtttttcgag tgaatgtcaa tgacttctgt gagatctccg 2665861 ctgctgattt ttgcagacgt tgagacaagt tttcttaacg gcttggtgat ggcacggata 2665921 atatagagta tgagtatgcc gccgattact attgacacgc atagaatgat aaccgcagtg 2665981 ttcagcaccg ggcttgaagc atcttgcaat tcactgacaa aatatgtgcc cgcgattttc 2666041 cagccagtca gtttatttgt cgtaaaggcc attttctttt ctttgccttc gaatgtatat 2666101 tcaaatgagc cttctttttt ggaatatact tggtttgtcc aatcgccgga accggttgtc 2666161 cccggcttaa tggtcggatg ggcgatatat tttttgttgc ctgtcgtaat aaatgcaaag 2666221 ccttcttttc cgattttgat tctttttgat gcagtaagca cttcatccag gtttaaatct 2666281 agcgctataa cccctgaacc gtcttttaat tgttttgaaa ttgtgacaac gatatctcct 2666341 gtcgcttcat cggtatacgg ttctgagaaa acagcttgtc ctttttccgc aaccgcctgt 2666401 ttgtaccagt cacgtcctgt cggatcgaaa cctttcggaa caccgctatc cggatattta 2666461 taaagcttct tatcttctga ggcagcatag attgcgccta catcgtcgtt aagtgtcgtg 2666521 tactgcttaa atttctcttt cagtaatgtt ttgtttttgc ctaacaatat gtctttatcg 2666581 actgtctcac tataataatc tattgctttt actttatctt ctaatttatt ttgcagcgta 2666641 ctgtttagtt cttcaacatt tcccttcgca ctgcttatga gctctctgtc taacgcgttc 2666701 caagctgatt gataactgaa atatgctaaa accccaaccg gcaaaataag cactgccaga 2666761 aacgcagcga ttagcggttt gctgatcgat ggctgtttga tccattgtat gaattttccc 2666821 attctcgttg actcctcctt taagataaat ctaatatcgt caaactagga taaaaggttt 2666881 aataaaaaaa ctaaaaaaaa cacccaagcg caacaagctt gggtgttaag gcttattatt 2666941 caattttaaa tcgtttggtc atatcccgaa gctcttccgc catagaggaa agggtctctg 2667001 cagacgagct gatttcttcc atggaagcta gctgctcttc agctgacgcc gcgatatctt 2667061 gtatatgcgc tgagctttct tttgaaatcg atgcaatgtg ctcagacgct cccgaaactt 2667121 cttcggagct ggcagaaagc tgctgaaccg tcgcactcat attttgcagt tcgccggcga 2667181 tttggttcgt catttcagaa atgcgtttga agctcatttc tgttttatct gtgatgtcaa 2667241 gtcctgtctg cacctcttga ttgacagatt ggaacatgcc gagtgatgta ttgatttcct 2667301 tcacaatttc gatgattaat ccttcaatct cttttgctga atctgctgac tgtactgcca 2667361 gttttcttac ttcttccgct acaacggaga agccgcggcc gtactcgcct gcgcgcgctg 2667421 cttcaattgc tgcgtttaag gcaagcaggt tcgtctggtc tgcgatgccg ttgatcacac 2667481 gcaaaatgtt tgtaatatct ttcgatttcg tttccaatcc gcgtacgact tgctccgctt 2667541 ctttaacgga cttgtcaatg acattcattt ggccgacggt ttgatgaaca agcttgccgc 2667601 cttcacttgc aatttctgtc gattgaacag atgaatcagt gatcacttca gaagcttgag 2667661 ccatattcgt caacccgtca ttcatttgat aaatgtgctc tgctgccgtt tcaatgtttt 2667721 cgttttgttt ttcattgccg ttagaaaatt gttcaatcgc caatgtaatg tgctctgttg 2667781 ccttgctcgt ttgcgcagct gatgcagtca gctcctcaga ggaagcggca acattgtcta 2667841 ccgaatcctg gatggcgtgt atgagagaac gaagtgacga cgccatattg ttaaagcttt 2667901 tgccgagctc gcccaattca tcttttgaac ggatatcaat ggtttccgtc aaatctccct 2667961 cgctgatccg cttagaggaa ccgacaagct gtttcagcgg tgttgtaatc gaccgaatga 2668021 tcaatgtcat gacgataatc cctatgataa tagctgcggc caagacaatt aaagcaaggt 2668081 gaaggacagg ctgggctgcc tcatggattt catccaaata catggtgccg ccgatcttcc 2668141 atcccgtcaa cttgtttgtg tcaaaggcca tttttttctt atcgccatcc atggtgtatt 2668201 gaaaatcgcc tttatcagca ctcaacatct tatcgagcca gtcgcctttt aattcagttc 2668261 ctgattgttc attagggtgt gcgacaactt ttttgtcctt cgtcatgata aatgcgtagc 2668321 cttgtgtgcc gatgttgact tttttggttg ttttcagcag attttcaatc gtcatgttga 2668381 ttgcgataac gcctgaacca tcttttgtct gctgggcgat tgtcacaacc atcgtatttg 2668441 tcgacgcggt tttataaggg tctgtgatca cgactttccc tttatttgca accgcttttt 2668501 tgtaccagtc gcgttcaacc ggattatagc cgcttggcat cggaagatcc ggatagcggg 2668561 taaagtgccc ttttgtgtca cttgtataaa tggattctac atccttgtta atgctgatat 2668621 attgtgagaa tttctctgca atgcttgcat tgctttttgc attgtatttc tcttttgtca 2668681 gccattcgct gaaataatca gcactgtttt ctttttcgcc gatgctggtg ttaatgattt 2668741 cgtttaattg ctgtacattt tccaatgcgc tccccatcat ctgtctgtcg agtgagctgc 2668801 tagccgattg atacgcaaag atcgccaata tgacaaccgg tatgatgagg atcgacagaa 2668861 aggaaacgag aagcttccgt gtaattgatc tttgttttat gagttggagt atttttttca 2668921 tcattcattt ctcctttttt atgctaccct tcatatcggc tggaaatggg taaatatata 2668981 cagcaaaaaa gaagaaattt aacaaaagta actaatttcc cataaataaa tagtatttta 2669041 gacctattat ttgtctactt taaattgttt tgtcagatca cggagttctt cagacattct 2669101 ttcaagcgtc agtgcagatg aactaatctc ctccatggat gccagctgtt cctcagctga 2669161 agcggcgata tcttggatgc catccgagct ttccttagaa atggcagtga tatcatttga 2669221 agctgcggaa atttcttgag ctcccgctga cagctcctca accgtcgcat tcatgttttg 2669281 cagctcggaa gcaatttgat tggtcatttg cgatatatgt ttgaagctct gtttagtttc 2669341 atccgtcatg acaagccctg tttcaacttc tttgtttacg gactgaagca cgttcagtga 2669401 tgtgtgaatt tcttttacta tttcactgat cagcgattca atttcttttg ctgagtcagc 2669461 cgactgtacc gcgagctttc tcacttcctc agcgacgact gagaagcccc ggccgtattc 2669521 acccgctctg gcagcttcaa tggcggcatt taaagccaaa agattggttt gatccgcaat 2669581 gccgttgatg acacgcaaaa tattcgtgat atcctttgat ttgatctcca gccctttcac 2669641 cacttgttcc gctgctttta cggaatggtc aattgtgttc atttggccgg ctgttttctg 2669701 gacgagtgtc tcccctttgc ttgacacttc ggttgaatct gcggatgttt ctgtaatcac 2669761 tgctgcagcc cgcgccagct ctgccaatcc gtcattcatt tcattaattt gttcggttgt 2669821 cgtttctatt ttctcgcttt ggctttcact gccgtttgaa aattgctcga tagccatcgt 2669881 aatgtgctca gtggctctgc ttgtctggtc tgccgatgca gtcagctctt cagacgagga 2669941 ggcaacgtgt tctactgagt ctttgatccc gtgaatgagc gagcgaagcg agtgtgccat 2670001 atgattgaag ctctcactca gaacgccgag ttcatctttt gaattgattt caatcgtttc 2670061 ggttagatcg ccttcactaa ttttttcagc ggatgcgaca atgcgtctca atggctttgt 2670121 gatggatcga atcacaaaat aaatcgccgt cattccagct ccgatggcaa tcgccagaac 2670181 gattgaagcc atgatcagaa ccctgcttgc agcatcgtga atctcgtttg catacatcgt 2670241 gccgctgatt ttccagcctg ttgtttggct tgttgcaaat gccatttttt tctttttgcc 2670301 tttgtacgta tattcaaagt ccccgctttt atccttgtag agcttatcaa cccagtcccc 2670361 ttttagctct gttcccgctt tttctccgga gtaggcgatg actttcttgt tttggctcaa 2670421 aataaaagca tagccttctt ttccgatatt gattcctttc gcggtagtga ctaagtcatc 2670481 aattttcata tcaatggcga caacgcctga cccatccacc gtttgacggg cgatggtgac 2670541 gaccattttt cctgatgaaa tcgattcata aggctcagtg acaattgttt tgcctttatt 2670601 ggccattgct tctttgtacc aatctcgttc caaagcatta aagtcgcttg gcatgtcagc 2670661 gtacggataa cgtgtgaagt ccccgtcttt gccgcttgaa aataccgcag cgacattatc 2670721 attcatttgg ataaattgtt taaattcctg tttcagctct gttttctttt tatcctgaaa 2670781 tttttctgct gtagcccaat cgctgaaata tgcgaggctt ttttcagtag tgctgatttt 2670841 atcatcaatg atgtgatcta atatctgaac attttccttt gcgctttgcg tcatctgtac 2670901 atcaagtgag gcaactgctg attgataagc gctaaccgaa agggcggtta tcggaacaat 2670961 taagatcagc aggaaagaaa taataagtct ccttgcaatt gatgatctgc gaatagtggt 2671021 gagtgttttt ttcatttcct tttgaacctt ctttcaataa tttacaaatt atatcggcgg 2671081 atcttccttt aaattacatt gaaaatggag gaaaaaatga aaaatagttc taaattcacc 2671141 tgttaaacta ggactttatt attgtttacc atataaaaaa acagcgcttt gatagcgctg 2671201 tttttcggtt tttactcgat tttaaattgt ttcgtcagat cgcgaagctc ttctgccatc 2671261 tgcgcaagag tcgtcgctga ggaactgatt tcttccatgg aagcaagctg ttcttcagct 2671321 gatgcggcaa tgtcctggat gcttgccgag ctttctttcg acacgtctgc aatgccgctg 2671381 actgctgctg aaacatgctg tgaacggtct gacagctgct cgacggtgga attcatcgtc 2671441 tgcagcttgc ccgcgatttc gtttgtcatg ctgaaaatgc tctggaagct ttcttttgta 2671501 ttgtctgtga caacaagtcc ggactgtact tcctgattga cctctttaaa catgtgaaga 2671561 gaggtgtcga tttctgcgac gatttcttgg atcagctttt cgatttcttt cgctgaatcg 2671621 gctgattgga cagccagctt gcgcacctcc tccgctacga cagagaagcc gcgtcctgac 2671681 tctccggcac gcgccgcttc aatggctgca tttagtgcaa gcagatttgt ttggtcagcg 2671741 attccgttga tgactctcaa aatgcttgtg atgtcttttg attttccttc taagcctttg 2671801 acaacagctt cagcctgctg aacagattga ttaatcgagt tcatttgtcc gactgtctgc 2671861 tgcacaaact tctcacccgt tccggcgatt tccgttgatt ggatagatgc ctttgtaata 2671921 tctgacgatg tttgtgagac ttgctggagt ccttcattca ttaagttcag ctgatgagag 2671981 ctggattcaa ccttttcgct ttgctcctcg tttccgtttg agaactgctc aatcgccatc 2672041 gtaatatgct cggtggcttt actcgtctgc ccggcagatg cggtaagctg ttcggaagat 2672101 gcggccacat tgttcaccga gtcctgaata gcgctgatca gagagcggag agattgtccc 2672161 atttcattga agctttcccc aagctctcca agctcatcct ttgaatggat ttcgatcgtt 2672221 tcggtcagat cccccctgct gatcgttttc gatgattgaa caagacgttt taacggtttt 2672281 gtaatcgaac gaacgataaa cagaattaaa attccgcctg ccacaatgga agcaatcagc 2672341 acaatcattc ctgttgtcag cacagacttt gaggcatcct taatttcatc catatacatt 2672401 gtgccggcta ttttccaacc agtcagttcg tttgtagtat aggtcatctt tttatcttcg 2672461 ttattaagag tatactggag ttcaccgctg tcattcgcat acattttggc tacccagtcg 2672521 cctgaaagct tttctccagc cttatggttc ttgtgggcga cataggtttt gttttttgtt 2672581 gcaatgaaag cataaccttc ttttccgacc ttgatttgtt tcatttgttc taacaattta 2672641 tcaatggtaa tatccatggc gacaacgcca gatccgtcct tcagctcctg tgcaatggta 2672701 atgaccatgc ttccgtcact cgcagccacg taaggatctg tcacgacaat ttcaccgccg 2672761 gccttcatcg catcctggta ccaaggccgt tgtctcgggt cgtatccttc cggcaatttt 2672821 tcttttggcg cttgtacata agtgccgtta tctgcgcccc cataaattct ggctactcct 2672881 tgattaatag atacatattg tgaaaattta gctttgatct cttcttgatt tgatttccct 2672941 ttgaatgcgg atcttttaag agattcactg aaaaaggtga ctgctttcgc tttttctccc 2673001 agatcatttg taacagttgt attaaatgta tcgacactgt ttttcgcatt tcccataatt 2673061 tcctgatcca gctttccgct ggcgcttcgg taagagctaa attctaatat aagaataggg 2673121 ataatgagaa tcgcaataaa tgagacgatt aatttctttg aaatagacgg tttcttcagc 2673181 caattgataa aagtcttcat gtcacttgct ccttcaggtt tgatacagta tatatcggct 2673241 gcttaaaaaa gttttaaaat aaaaaatgga agaagttctt tttggctgtc ttctgccttt 2673301 ttaactttca ttgcccaagc tctttgcata tcttataaaa aacaaggggg gctaaacatg 2673361 attattgtat caggacaatt gctccgtccc caggatattg aaaattggca gattgatcaa 2673421 gatctgaatc cgctcttaaa agagatgatt gagacgcctg ttcagtttga ttatcattca 2673481 attgctgaac tgatgtttga gcttaaactg cggatgaata ttgtagcagc ggcaaagacg 2673541 ctgcacaaaa gcggggcgaa gtttgccact tttttaaaaa catacgggaa tacaacgtat 2673601 tggagggttt caccggaggg cgccttggag ctgaaataca gaatgccgcc ttcaaaagcg 2673661 attcgggaca ttgcagagaa cggcccgttt tatgcgtttg aatgcgcaac cgcaatcgtt 2673721 atcatttatt acttggcctt aatcgataca atcggagaag ataaattcaa tgccagcttt 2673781 gacagaatta ttttatatga ctggcattat gagaaattgc cgatatatac ggaaacagga 2673841 caccactttt tccttggaga ttgtttgtat tttaagaatc ctgaatttga tccgcaaaag 2673901 gcgcaatgga gaggcgaaaa tgtgatacta ctgggggaag ataaatattt tgcccatggt 2673961 cttggaatct taaacggaaa gcaaattatt gataagctga attcttttag gaaaaaagga 2674021 gccttacagt cagcctacct tctgtctcag gcgaccagac tggatgttcc gtctcttttc 2674081 cgcatcgtcc gctaaaaagc cccatcgcct attttccgga cgatggggtt tcaaatgcct 2674141 ttcgttttcg atagaagggg gctgtgccaa aatattggtt cgcagcccac tccatttttt 2674201 caaggtcatt tcttgtcacg attggatcct ggctgctcca tttgataaag cggacaaaat 2674261 agtagccttt gataggaacc attgtaactt ttgagtgagg ccagccttca aatacaaact 2674321 caattttccc tcttttttta taagaatatt gaagaatgtt catatctgtc acctcagttt 2674381 atcaagttac gttcggcaaa gctcggtacg tttacatcca ttgattaact atccctcatg 2674441 caggctttcc ggaaaacaaa gggtgaggcg cgtgtctctt tccctcgctt tttatttcgc 2674501 atatggacga atgccaagca cgccttcatt cgataaagcc gcagcgtggg cgggtgtgac 2674561 aagccctccg gctatcggcg cttgttcagc gatcatgctt ttgtcataaa aaacagccta 2674621 ttatcccatc attttgatat agcatgtccg ggtgcgaggc ccgtcaaatt cgcagaaata 2674681 aatgccctgc cacgttccaa gaataagccg gccgttttcc acaatgacat gctgtgaagc 2674741 tccgaccgta ctcgacttca tgtgtgcagc tgtattgccc tccatatggc ggtccagctc 2674801 atgttcccac ggatatacct catcaaacct tctgagcata tcttttttga cgtccggatc 2674861 ggcattttca ttaattgtaa tgcccgcagt cgtatgcgga cagtaaatca gcgctgcgcc 2674921 gctcgttata cctgtttctt gaagaaacgc ttccacctcc cgggtgatat ctatcatttc 2674981 atctcgtttg gttgttttga tttgcagtgt tttcagcatt tgtttctcct ttcgtttgtc 2675041 cgctctcatc gcttaattcg ttctgtgttc ttttttttcc tgttaaaccg ctctcataaa 2675101 cccgataaaa caaaaaaact ccagtctaag gctggagttt agcaccatag atatattctt 2675161 gcttcatacg gctttaagag tactgatgtc atatgcttgt gcggctctgt ttcaatattt 2675221 gacaagacga gtgcatctga tgacaatggc aatccagagt gcctgaacaa cgccggtgtt 2675281 cctgtcagat tggccgcaat cagtgcagta tggctctcgt ttttccgaag atatgcaaag 2675341 atttgctgat cttccggtaa aatgagctcg tatgtcccgt taataaaaac atcatatgtt 2675401 tggcgcagct tgatcaagct tttgtaaaaa tggtaaacgg atgttttatc gtttttttgc 2675461 gcctcggcat tcagccattt gtaattctca ttgattccga tccacggttt ggcctcagaa 2675521 aatccggcgt atggaccagc attccattgc atcggcgttc gcgaattgtc tcttcccttt 2675581 ttccagacaa tcttcatcac atcctcgtgt gatgtgcctt tcgctgtttt tgtttcatac 2675641 aggcgtttca atgcgacatc atcatagtcc tcaatagatg gaaaagccac gttcgtcatc 2675701 ccgagttcct gtccctgata aataaacggt gtgcctttca tgagaaaata aacagcggaa 2675761 agcgcttttg cactttcttt caggtacact ccgtcgtctc cccacacaga aactgaacgg 2675821 ggctggtcgt gattctccat aaacaaagca ttccagccga tcccttccag actgtcctgc 2675881 cagtcagtta aaattcgttt aaatgcaacg atatcaatac tttcattgat ctctacatcc 2675941 cacaggccga gatgctcaaa ttgaaaaatc atgctgaata tgccgttttt ttctccagcc 2676001 caatcagctg cttcttttgc agcgacgccg tttgcttcac caactgtcat aatcggatag 2676061 cgggaaaatg tgttttcctt cagctctgtt aacaaatcca taatgccgtc agcattcata 2676121 tgataaggaa aggaagggac atagtccagt ccctttggat tcggcatgtc aggaaaccct 2676181 tcttttttct taatatgcgt aatggcatcc acccgaaatc cgtcaattcc tttatcaagc 2676241 caccaattga tcatgtcata aacggcattc ctcacctttt cattttccca attcaaatca 2676301 ggctgttttt tatcaaaaag gtgcagataa tactggcttg tcttttgatc atactcccaa 2676361 gccggcccgc cgaaaatgct ttcccaattg ttgggcgttt ttccgttttt gccgtctttc 2676421 caaatatacc agtcgcgctt ttccgagtgt atggatgaac gggattctat gaaccatgga 2676481 tgttcgtcgc ttgtgtggtt cacaacgaga tccataatca gcttcatatc cagatcatga 2676541 atgtcaccaa gcagctcatc aaaatcttcc atcgtgccaa actcgcttaa tatgttttga 2676601 taatccctga tatcatagcc attatcggca ttcggtgaat catacagcgg gcaaatccat 2676661 atgacgtcag cgcccagctc ttttatgtaa gaaagcttgg ttctgattcc ttgaatatcc 2676721 ccgattccgt cgccatttga atctttaaaa ctgcgggggt aaatttggta aactacggct 2676781 tccttccacc aagccttttt catacagcca ctccttccca gtgtaccgtt cttatatatc 2676841 ctatgtagaa aaaggtcttt acagcattgc tttttaagaa atgacttgat gacacaaaaa 2676901 acagccgttt gttccccggc tgttttttat caaaaatcag ttttttttat ttctacaaaa 2676961 cggatgtggt gatcttcggc gtcgaggatt ttaaattcac agccctccgc gtgtatcaca 2677021 tcccctgctt tcagctccat tttttgcgtt agaagccagc ctgcaatcgt atcaatttct 2677081 tcattttcaa tcgcaatgtc gagaaggtca ttcacttcgt ctattagcgc ttttccatcc 2677141 atcacataat ggtgctcgcc ctttttcagg atgtgcggtg tttcatcctg atcatactca 2677201 tcgcggattt ccccgacgat ttcctcgata atatcctcta cagtgacaag ccccgccgtt 2677261 cccccgtatt catcgacaag aatcgccatg tgaatccgct ccttctgcat gcggattaaa 2677321 agctgctgaa caggaatgct ttcaatgact ctgataacgg gcctcatgat ttgattcagc 2677381 tttatcggct ggccgagaaa ataagcttta aacatatctt tgctgttgat gatccctaaa 2677441 atatgatcct tgtcatcttt gatgacaggg tagcgtgtat accgttcatt aatgatgtga 2677501 tgaattgcct cttcaagcga ctgctccaga gagataaccg caatttctgt ccgcggaatc 2677561 ataatctctc tcgctacccg gttgtcaaat tcaaaaatct tatttacata gcggaattca 2677621 gactgattga tttctccctt ttcatagctt tcagaaagga tcagccttag ttcctcttcg 2677681 ctgatgacaa cctgatgctc ctttaccgaa tgaaagccaa acaatttcac aagaaaactt 2677741 gcagagccgt ttaatgcttt aataaacggg tacgtgattt tataaaacca gatcagcggc 2677801 tttgcaatcc ataagcttac agcttcagct ttttgaatag aaaccgtttt cggggcaagc 2677861 tcccccatca ccacatgcaa aaaagtgacg atgataaatg caactacaaa tgtgacaatg 2677921 tggttaaacg gttccggtat gcctgtcatt gtaaataagg gatgaagaaa acgttcaaat 2677981 gtaggttcac caagccaccc aaggccgagg gctgtaatcg taatcccgag ctggcaggct 2678041 gataaatact cgtcaagatt ggagatgatt ttatgtgcgg ctagtgctcg gctgtcaccg 2678101 ctttcgatga gctgattgat ttttgaacct ctgattttga cgatcgcaaa ttccgctgca 2678161 acgaaaacag ccgtaatgcc aatcaaaaca aaaatggcga tcaattgtaa aataagcaaa 2678221 aaaagccctt accataaatg gtaaggggcc acctccttaa cgttaattct catcacgacc 2678281 gtttaagaaa atcatcacaa aacgaagtag ttcaaacagg gaaaccaggg cggcggccac 2678341 atacgttaag gcagcagcac tcagcacttt atttacccca ttttcttcat tgtttcggat 2678401 gaatccttct gacacaataa tctgcttcgc acgtgaactt gcattgaatt cgacaggcaa 2678461 tgtaatcagc tggaaaaaga cagccgctga aaacagtatg atgccaagcc cgatcaaatt 2678521 caggctgccg agaagcatgc ctcctaagaa aagcaaagga gctacaccgg atgcaaaatt 2678581 cacgactggg aagattttat gtctcagcac aagcgcacca tatgactcct gatgctgcaa 2678641 ggcatgtccg acttcatggg aagctacgga tatggcggaa attgagcggc cgtaatagac 2678701 cggctcagat aaacgcacca cccgtcttgt cgggtcgtaa tggtctgtta aagtgcctct 2678761 taccggttcg accggcacgt cgtaaagacc gtttatatct aaaatccgtc ttgccgtttc 2678821 tgcccctgta cgtccgcttg aggcttccac ttttgaatat ttttcaaagt tgctctttac 2678881 tttaaattgt gcccaaaacg acaatcccaa tgcggctatt gttaaaaata taaacagcat 2678941 tttttcatca tcctttgttc atgatcattt ctctattacg attattttaa tgagttttct 2679001 ttctcgtgta cagaaatgcg ctttttcttc cggcttggag cacacaatcc aatcagcaaa 2679061 aagaacaggc ctgctgaaaa caaataaaag gcgaaactgc cggccagttc tttcagaaaa 2679121 tgaagccagg agaagcttcc ggaaaagtga ttatatgaat tcaaatcgaa aataaacaaa 2679181 atcaccgcgg atgccgccag ctgcgtaccg attaaaacca cgatcgttct ttgaaagatc 2679241 gtcatctttt tcatcctttt tgttttagtt tatggagaaa tccggtttta tatgttttgt 2679301 acattttttg aaaaacatca ccggaagtgg gacatactgt tagaaaaaag cacgggtgtg 2679361 atggaagcta tgaaagtgac gagtgaggaa aaggaacagc tgagcacagc aatcgaccga 2679421 atgaatgaag gactggacgc gtttatccag ctgtataatg aatcggaaat tgatgaaccg 2679481 cttattcagc ttgatgatga tacagccgag ttaatgaagc aggcccgaga tatgtacggc 2679541 caggaaaagc taaatgagaa attaaataca attattaaac agattttatc catctcagta 2679601 tctgaagaag gagaaaaaga atgaaatcaa atcggatatt tatttcatgg ctcaggtggc 2679661 cgttatttat ccgaatcggg gttattattt tatgtctgat tcttttgttc ggccaaatca 2679721 tttatatact tgagcctaag cagttcactt cggtattcga aggtatttgg tgggctgtcg 2679781 ttacggtttc tacagtcggt tatggagact atgtgccgca cactccgctg ggacaggcag 2679841 ccggaatact gctgattttg agcggagcaa gctttgtcac agcgtatttc gctacgttat 2679901 cagcggccgc attcagcaga cagcatcgct acattgaagg aaaagttgct tacaaaggcc 2679961 gggaccacat cattctgatc gggtggaatg aaaaaacaaa ccggcttttg aaggaccttc 2680021 agcttgccgc cccttccaaa acagtcgtac taatcgatga atccttaaca gaaggcccgc 2680081 ttattgaaaa cgttcatttc atacgcgggc acgctgccga tgatgggaca ctgaaacggg 2680141 ccaatattac tgaagcggaa tcagtgatga ttactgccga tcagtataaa agtgaaactg 2680201 atgctgatat gctgtcagtg ctgactcttt tatctgttaa aggtcttaat ccccttgctt 2680261 actgcatcgt cgagatttta actgaccgtt ttgtcaccaa tgcggaacgg gcaggcgcaa 2680321 accaaatcat cggaacttca gaatttatca gccgggcgat gctgcagcat taccaagtca 2680381 agttacggcc gtctaaacag cagaacggaa tcaagctgac acttgatcag catgtggagc 2680441 ttcttgctgt tcctgacgaa ctaaagggag cggcttacaa aacctgtgtt ctctatttcc 2680501 ttgatcacaa cacaacaatt ataggcatac aaaaaaagga ggggccgatg ctttcccctc 2680561 ctcttacata caaggtgctc gaaacagatc aattccttgc catctagtgt aacagaacat 2680621 cctccaattc tttcacgaga gaggcgccga tatccaaaaa tgccggatca atttccgcgt 2680681 cccgcctttc cggttcggaa aattgattaa acagtgattg gaaaggccct ccctcggcgt 2680741 gatcgtcaac atccgcctga aacacctgtc tcagcataaa tggcgttccg atccggacgg 2680801 ccgcccctcg ttcatcgaga ctgccctgta ccgcattgac gggaattctt aaaaataaat 2680861 agccgtctct atcatcaatt ttataatcaa agtagccatg atcgtattcc cagccgccgt 2680921 ttatcacata accgagcggc ttcatcactt gttccagttc ttgaagcaga aaagactgcc 2680981 catctatcgc ggaaggtatt ggtatcatca gaatgcccct tttttcactt atcctgtccc 2681041 gccgaacaag acttcattca gaggcgccta catggaaatc gttgtttctt tcgcgcggcc 2681101 aacaggaaag aaagcgcatt caattaagaa gtaaacagcc attgccgctg caagccatac 2681161 agctgaatcc caagacacat aaacaaccgt tgcatagagt cctaatttag tgaaaagagt 2681221 atgggttcgt tttaaatgca aaatccgatg taccgcatcg gtaaaaaggg caagcggcaa 2681281 accaatgaga agaaaggagt ggatgaaaaa atgtgacagc gtgccgccaa agcttgaaga 2681341 aaaccctgta tacacggcat caaaggagat aaggaaactt aaaatagctg cagaaaaacc 2681401 ggcaatgatg agatgtttaa ccaattgttt catgaacatc agcacctttc tgattttata 2681461 aaaagccgac cggcaaatgc cagtcagctt tctcacatta atcttccaga cgtttttcaa 2681521 gctctgcttt tttctcttca aagccaggtt tgccgagtaa cgcaaacata ttgactttat 2681581 acgcttctac accaggctgg tcaaacggat tgacgccaag gaggtaaccg ctcatcgcgc 2681641 aggctttttc gaagaaatat acaaggtatc caaaagtata tgcattcagc tcaggaatgt 2681701 taacgattaa gttcggaaca tttccgtctg tatgggcaag cattgtacct tggaatgctt 2681761 ttttgttaac gaaatcaaca gttttaccgg ctaaatagtt caagccgtca agatcgttat 2681821 ccgcttcctc aattgtcagt tcatgtttag gcttctctac gttcaggacc gtttcgaata 2681881 aatctctgcg gccttcttgt acatactggc ctaaagaatg aaggtctgtt gaatagttcg 2681941 ctgaagaagg ataaatgccc ttctcatctt tcccttcgct ttctccgaac agctgcttcc 2682001 accattccgc aaagtattga agcgccggtt cgtagttgat gagcatttca attgttttgc 2682061 ccttattata aaggacattg cgaacaaccg catattggta tgctgggtta tcttccagtt 2682121 cagatgttgc aaaatctttg ctcgcatcca gggcgccttt catcatgtcg tcaatgttga 2682181 cgccgctgac agcaatcggc aagagaccta cagctgttaa aactgaataa cggccgccga 2682241 catcgtcagg aattacgaat gattcaaagc cttcttcgtt agaaagcgtt tttaatgcgc 2682301 cgcgctcttt atcagttgtt gcataaatcc gcgctttcgc ttcttcttta ccgtatttct 2682361 cttcaagaag cttgcggaaa atacggaaag cgattgcagg ttcagttgtc gtacctgatt 2682421 tagaaatcac attaatagag aagtcaacat cttcaagaag atccatgacg tctctcatat 2682481 aagatgaact gatgttgttc ccgataaaaa tgacttgcgg attgccgcgt tttgcttttg 2682541 gcaaagtgtt ataaaacgcg tgattcagcg cttcaatcgc tgcccgcgct ccaagataag 2682601 aaccgccgat gccgacaaca agcaagacat cagagtcaga tttgattttt tccgcgcttt 2682661 ttttgatgcg cgcgaattct tctttatcat aatgttcagg gaggtccacc cagcctagaa 2682721 aatcgctgcc cgcgcctgtt ttctcatgga tattatggtg tgctgttttt acaaagtccc 2682781 gcaggtatgt aagttcatgt tcgttgaaga aagtcaacgc ttttgagtag tcaaagcgta 2682841 catgcgtcat tgcttgtccc tccataacgg tataatgttt tcatctttca ctttatatga 2682901 acttatctgt gaaatcaagt caagaagaaa gggcggaatg actggattcc gccctttggg 2682961 tttatagaga cgcgcgaagg atggcaagca cgtcatcttt gttcagtttt tggaagttgc 2683021 cgaagccgcc gtgttccatt tccttggctg cgatatcagc aatcagctca agcttttctt 2683081 ctccaatatt gtaatcagca agacgagaag gtgcaccgag gcttgtccag aacgcagaca 2683141 gtttatcgat tccttcaagc gcaatttctt tatctgtttt gccttcagta tcaatgtcaa 2683201 acatgttgag cataaggttt ttaaaacggc ctacatttgt atcaagcgtg tatctcatcc 2683261 aatttgggaa cagtattgcc aaaccgcccg cgtgcggaat atcatataca gctgaaacag 2683321 cgtgttccat tgtatgagaa gcccagtcac cgaagtatcc catttggagc gtgccgttta 2683381 aagcaatagt accagcatac aaaatcgttt cacgaagttc gtagttttcc agatcttcaa 2683441 gaagcttagg agctgtttcg atgaccgtct gcaaaacagc aaagcacatt ctatcctgaa 2683501 gcggcgtgtt ttcaacatta tggaagtatt gttcgaatac gtggctcatc atgtcaacca 2683561 tgccgtatac tgtttgattt tctggaacgg tgaacgtatt ttcagggtct aaaatagaga 2683621 aacgcggatg agtgacattg ctgccccata caaatttctc gtttgtttcc cagtttgtaa 2683681 tcacggaatc agggttcatt tcagaccctg ttgcagcaag agttaaaaca gtgccaaacg 2683741 gcagcgcatc ctccgctgtt acttttttgc tgaaaatatc ccaagcgtca ccgtcatatt 2683801 tgacgccagc tgcgattgcc tttgtacagt caatcacact gcctccgccg acagcaagca 2683861 gaaaatcaat gtcatgctct ctgcaaagtc ctatgccttt ttccactgtc gcaagacgcg 2683921 ggtttggctc tacacctgac agctcatgaa caacagcgcc ctcttctttt aaaatgcctg 2683981 tgacttgatc ataaaggccg ttgcgtttaa tgctgccgcc cccgtaaaca agcagtacat 2684041 tcttgccgta tcgtttgaat tcttttctta attgttcaag ctgacctttt ccaaaaatca 2684101 gctttgtcgg attataataa gtgaaatttt ccatagtaaa acctccaaat gatgctggta 2684161 aaaaacagat tttccattgt aacataagtt gacaaaaaag aaaaagggaa gcagccaaac 2684221 ggctatttcc ccttttttta tagtgatgct ttcaaaattg acagcacatc ttctttgttg 2684281 agtgatttaa attggccgaa tgtaccgtta gccattgcct tgtcagcgat tgtgtcaagc 2684341 tgctcatcat taatatcata atcagcaaga cggttcggag cgccaagact tgtccagaat 2684401 gcggacagct tatcgatacc ttcaagggca atttcttcat ccgttttacc tgcttcttca 2684461 acatcaaaca cgcgaactgc aagctgtttc atgcgggcag ggttttcaga caatgtgtgt 2684521 ctcatccaat tcgggaacag aatcgccagt ccgccggcat gcggaatatc ataaacggct 2684581 gatactgcat gttcaatatt atgagtagcc caatcccctc ttgcccccat agaaagcatg 2684641 ccgtttaatg cgattgttcc tgtgtacagg atcgtctcac gcaattcgta attttcgaga 2684701 tcattgatca gcttaggcgc tgtttcaatg actgtacgca aaagtgattc acacatgcgg 2684761 tcctgatacg gcgtgtttga tacatgatgg aagtattgtt cgaatacgtg gctcatcatg 2684821 tcaaccatcc cgtagatcgt gtggttttta ggtacggtga atgtattcac cggatcaaga 2684881 atcgagaatt tagggaatac gagcgggctg ccccagccgt atttttcttt tgtttcccag 2684941 tttgtaataa cagatcctga gttcatttct gaaccagttg cagcgagagt caataccgtt 2685001 ccgaatggca aagcatcttt tggctgatgc tttttcgtaa cgatatccca cgcatcacca 2685061 tcatacttcg ctcctgcggc aatcgctttt gtacagtcga ttacgcttcc gcctccgaca 2685121 gccagcaaga aatcaatgtt ttgttcttta cagatggcaa cacctttatt aacagtcgac 2685181 acacgaggat tcggttccac acctgctaat tcatgcacgg tcgctccggc tttattcagc 2685241 tgttcaatca cttgatcata caggccgctg cgtttaatgc tgccgcctcc gtacacaagc 2685301 aatacgtttt ttccgtaagg tttgagttcc tccggaagtc tttccacttc gccgcgcccg 2685361 aaaattaatt tggtcggatt ccagtatgta aagttttgca tgacatctcc tccttagatt 2685421 ttttattatg cagaatgtcc tcaccacatg taaagcaatc agctctcacc gatcagcata 2685481 ccagatggtt ttattttgca aggtgctggg aaagaagctg atataagcga gggcaggcca 2685541 gcttccctca tatggagaat gcatgtatag attctccaat atgtcacaat ctataactgt 2685601 tttaataatt catggaggag gttgcaaaac atgagtacca ttcaaagaat ttgtcttgta 2685661 ttaaccatca ttggcgccat taactgggga ctgatcggat ttttccaatt tgacttagta 2685721 gcggctatct tcggcggcca agggtcagct ctttcccgaa tcatttacgg acttgtcgga 2685781 atcgccggct taatcaacct cggtctgcta tttaagccaa acgaggaaag atcacgtgaa 2685841 gaagcagcaa atcctgaaat gcgataggat atcaatcacg ctgaaatagg attttgcatg 2685901 aaatcaaaag caccgaacat tcctgtccgg tgcttttttc atgcttattt tttgataagg 2685961 tctttgcggt tggacatttc gatccactct tcaagcttat cttttaatgt gttgaaacct 2686021 tgtggtgtag aagcttcttc gcttacttga gcagctttag gttttcttgg tttgctttct 2686081 tttttctcag gcgcagcttg tgtcgcacga attgaaaggc tgattttgcc tttttcttca 2686141 tcaacagcaa gtacttttac ttgtacttcg tcgccaactg aaaggtgctc gttgatatct 2686201 tttacgaaac cgtgagtcac ttcagaaatg tgtactaaac cttgagtttc ttcatctaat 2686261 gcaacaaacg caccatacgc ttgtaatcct gtaactttac cagtgtaaac actgcccact 2686321 tcaaattttg ctgccattca taacaactcc taagttaaat taaatatctg tttatacgca 2686381 atttaaaatt atatcacaca tgtcttattt ccgcaaagaa aactttttta taaaaaatca 2686441 ggtttatgca cagcaaaaag ggggtaaact gaaaatacca aaggctttct agtattcccc 2686501 ccttttattg gatgcgaaca aaaggttcgt atcttttttt atgttgtttt gtgcaggaag 2686561 cgtttcattc tgactaacgc ttcttgaagc tgttcaatcg aggttgcgta tgaacaacgg 2686621 atatatccct caccgctcgg accaaacaca cttccaggaa caactgccac tttttcctgc 2686681 gtcagtagct cctcggcaaa ctgttctgaa ctcattccca tgcttttgat agatggaaaa 2686741 gcatagaaag cgccgcccgg atgatgacag ctgagaccga tttcattgag cgattctaca 2686801 aacagattcc gtcttcttcg atagcttttt ttcatttttt ctacgtcttc catgccgttc 2686861 ttcaggcctt caagggcggc aaactgcgcc attgcgggcg cgcacatcat cgcatactga 2686921 tgaattttaa gcatggcatc ccgaagcaag gatggtgccg cggcaaaacc gagcctccag 2686981 cccgtcattg caaatgcttt tgaaaagcct gagatgacta ccgtccgttc cttcattccc 2687041 ggtaatgccg ctatacttgt aaattcctca tcatatgtca gctccgcgta gatctcgtcg 2687101 gctaagacga tgacatcatg ttttttggca aactcagcaa tctcattcag ctcttccttc 2687161 gaataaaccg aacctgtcgg attcgatggt gagcagatga gaatggcctt tgttttttca 2687221 gtgactgccg cttcaaaatc agcagccgtt gctttaaatc ctttgtctgc cgttgtatga 2687281 acgtgaaccg ggataccgcc tgccaaagaa acaagcgcat cgtacgcaac aaaacacggc 2687341 tcaggaatga tgacttcctc acctggattc acaatggcgc ggatcgcaat atccaaagcc 2687401 tgacttgccc ccactgtcac aatcagctca ttatctggcg agtagctaag gtcaaacctg 2687461 ttgctcaaat aacggctgat ttcctcccgc aatgagtata aacccgcatt ggccgtgtat 2687521 gacgtatatc cttgttcaag agagagaatg cttgcttcgc ggacattcca tgcggtaaca 2687581 aaatcaggct cgccgacgcc taaagaaatg acgccttcca tcgttgccgc caaatcaaag 2687641 aatttgcgga tgccggatgg ttttatttgt tgtacatagt ctgataaata cgaagtcatt 2687701 tacggtgaca ccacgattct tttgtcgtcg tctcctgttt caaacacttt gccgtcatgc 2687761 ttgtattttt tcaggataaa atgggttgtc gtagatacaa ctgaatcaag cgttgagagt 2687821 ttatccgaaa caaaacgcgc tacgtcagac atcgaattgc cgcgaatcac gacagacaaa 2687881 tcgtatacgc ctgacatcag gtaaactgat tcaacctctt ggaatcggta aatccgttcc 2687941 gccacttcat caaaaccgac gccccgcttc ggcgttactt tgacgtcaat catggccgta 2688001 acgccctcat gtccgtcgac ttttcgccag tcaatcatag cggaataatc gataataacc 2688061 ttttctttct ccagtttgtc aataattgtt ttcacttcat ttacagggat gcccgccatc 2688121 tttgcgattg tttctaaatc ggcgcggctg ttttcgtcta aaatttctaa tatttctgtt 2688181 tctttttctg tcaatttcat ttgattcaca cctttgcaat gtcaagaaat ctcatgacat 2688241 tatatcacgt tttttgacga atgctaagaa aaaacgagga gaaacttccg ctagaattga 2688301 caatttcagg gcataataca accatcaaaa aaagggagtg acacagaatg gaggcggttt 2688361 caccaataag gcggtttacg gtcgatggag tcaatgtata ctacgaacat tatcaaaatc 2688421 ccggcaggca aacgctggtc tgcgtacacg gttttttatc atctgcattc agcttcagaa 2688481 aagtaattcc tctccttcgg gacaagtacg acatcatcgc gcttgatttg cctcctttcg 2688541 gccaatctga aaaatcaaga acgtttatct atacctatca aaaccttgct aagcttgtca 2688601 ttgggatttt ggagcacttg caagtgaaac aggctgtgct tgtcgggcat tctatgggcg 2688661 ggcagatatc gctgtctgct gctctccaaa aacctgagct tttttcaaag gttgtgctgc 2688721 tttgcagttc agggtattta aaacgttcac acccgacgat tattttcggg acccatatcc 2688781 cgtattttca tctttacatc aaacgctggc tctcgaaaga aggcgtgatg aaaaatttat 2688841 taaatgtggt gcatgacaaa tcgctgattg atgaggagat gattgacggc tatggcagac 2688901 cgtttcagga cgagcagatt ttcaaagcca tgacaaggtt tatccgccac agagaaggag 2688961 atttagaacc cgagcaattg aagaaaatga acaagcctgc tctattgatt tggggcgagg 2689021 aggatcgaat tgtcccaatg gagatcggta aacggctgca cgcagatttg cctaattccg 2689081 tgctgtactc acttggccag accggacatc tggtgcctga agaacggcct gaacttattt 2689141 ctgaacacat tgctgatttt atcaaataac aaaaaaaccg gtgctgaacc ggttttttta 2689201 aggcgtgcag gagctgctgt ttttaatgaa taaaagctgg ccagccactt cccggcagct 2689261 ggcgatcggc agcgtttgtt caaaagaagt ttcaaatatt tgctgaatgc ttttcgccag 2689321 caagtcggga tcgttttcat catagactgc ctgcacgaca tcaacagcct ccgtttcgta 2689381 aaactcttct ccatatttaa acgggtccca tttggcaatg atcttaatca tttccctgac 2689441 cgcatgactt tcttccatat tcatcaccgc ttataataaa atttgcagtt ctatcttatc 2689501 atagtgaagc ttagaagaat aaacatacat gagggggtaa cagaatgaac tttgataaac 2689561 gagaagaacg ccttggcacc caatcggtca aatgggataa aacaggcgaa ttatttggcg 2689621 tgacagacgc cctcccgatg tgggtggcag atatggattt tcgcgccccg gaagcgataa 2689681 ctgaagcgtt aaaagagcgt cttgaccacg gtatttttgg ttatacaact ccagatcaaa 2689741 aaacgaagga tgctgtgtgc ggatggatgc aaaacaggca cggctggaag gtaaatccgg 2689801 aaagcatcac attcagcccc ggcgttgtaa cagctttgag catggcggta caagctttta 2689861 cggagccggg cgatcaagta gttgttcagc ctccagttta tacgcctttt taccatatgg 2689921 tggagaaaaa cggccggcac attttacata atccgctgct agaaaaagac ggcgcatatg 2689981 caatcgattt tgaagatttg gagacaaagc ttagtgaccc aagcgttaca ttgtttattt 2690041 tatgcaatcc tcataaccct tctgggcgtt catggagccg ggaagattta ctgaagctag 2690101 gcgaattgtg ccttgagcat ggcgtcacag ttgtatcgga tgaaatccat tccgatttaa 2690161 tgctgtacgg acataaacac acgccgttcg cttcgctctc tgacgatttc gctgatattt 2690221 ccgtgacatg tgctgctcca agcaaaacat ttaatatcgc cggattgcag gcttcagcga 2690281 tcattattcc ggatcgcctg aagcgcgcca agttttccgc aagccttcag cgaaatggtt 2690341 taggcggact gaacgcgttt gccgtcactg caatcgaagc cgcgtattca aaaggcggac 2690401 cgtggcttga tgaattgatc acttacattg agaaaaacat gaacgaagcg gaagcctttt 2690461 tgagcaccga gctgccaaag gtcaaaatga tgaagccgga tgcatcatac ttgatttggc 2690521 tcgacttcag cgcttacggc ttgtccgatg cagagcttca gcaaagaatg ctaaaaaaag 2690581 gaaaagttat tttagagccc gggacgaaat acgggcctgg cggagaagga tttatgcgcc 2690641 tgaacgccgg atgctctctt gcaaccctgc aggacggcct gcgccgcatc aaagccgcat 2690701 tatcgtaaat atagctgtaa acgcctttac gtcttcattt gtaaaggcgt tcttaataaa 2690761 ggaattttat attttacttc taatatttag tgttataata gattcatatt ttatacgaaa 2690821 ggatttcaca cgaatggaaa ttctaaaaga ctatcttctg cacatctgct ttattttgtt 2690881 tcctattctt ctttaccaag tgttttggct tggaaaacct gcgattcttg tgccaaaaat 2690941 aaacagcggt ttggtcacgc tcttcgcctg cggcgcctcc gttttatgca ttattttccc 2691001 gattcatgaa atggactaca tacaatacgg ccttcagatg attcccgtta tcatttgttt 2691061 attttacatt agtaccgctt ccggacttac agtcgccgca tctgtcctat gttttgaact 2691121 gcttttttac gaaccttccg caatgtttgt tttcactttg ctgccttttc ttatcattat 2691181 cccaatctta tttcagaaaa aatggccatt catgtccaaa gcgaaaaaac tgctgctgtc 2691241 tttattgatc agctgcgtgg agattttcct atttttcgcc tcaagctgga ttctttccgc 2691301 cttgaatatt ttaaattttc aaaaatcagg aattttcgtt tacgaggcgg cagtctcagg 2691361 gcttttccgc tccagtgttc ttctattaag catctatatt atcgaaagca tcgccgaaaa 2691421 tatcgccctg cgttcacagc ttatccattc tgaaaaaatg acgattgtga gtgaactggc 2691481 agcgagcgtc gcccatgagg tcaggaatcc gctgacagtt gtccgcgggt ttgtccagct 2691541 gctttttaat gacgaaaccc tacaaaacaa gtcgagtgcg gattacaaaa agcttgtact 2691601 gtcagagctt gaccgggcgc aaggcattat cacaaactat ctcgatatgg ccaaacagca 2691661 attatacgaa aaagaggttt ttgacctatc tgcccttatc aaagagacaa gctcccttat 2691721 ggtgtcgtac gccaattaca agtcagtaac cgtcgaggct gaaacagaac cggacctttt 2691781 gatatacgga gacgcaacaa agctgaagca ggctgtcatc aacctgatga aaaacagtat 2691841 tgaagcggtt cctcacggga aggggatgat ccacatatca gccaaaagaa acggccatac 2691901 gatcatgatt aacatcacag acaatggggt cgggatgaca gaccatcaaa tgcaaaaact 2691961 cggcgaacct tattattcct taaaaacgaa cggaacggga ctcggcctca ccgtaacctt 2692021 ttccattatt gaacatcatc acgggaccat ttcatttaac agcagcttcc aaaaaggcac 2692081 tacggtgacc attaagcttc ccgctgatct tcctcactag caaatcgatt ggaactttaa 2692141 tagaataaat gcgaggtgat gacagatgag cacgtttgag acaggctcta tcgttaaagg 2692201 attttacaaa acaggtgtat acataggaga aatcacggct tgcaggccgc agcattattt 2692261 agtgaaagtg aaagcggttc ttacccatcc cgctcaggga gaccttcatc atccaaaaca 2692321 ggcggatgtg ccattttttc atgagagaaa agcgctcgca tatggtgaac agaccaatat 2692381 cccccaccat atggtgaagc cttatgacgg tgaagtgccg gattataccg aatctctgcg 2692441 ggaggcgaca gcacagatga gagccaaatt gaatgaggat ggttcggagt gggcaaagcg 2692501 ctcccttcat aatctggaca ttttagaaaa agaatatttt aaccggccat aacccagtct 2692561 gacaaaagat tgggtttttt acgtcgcgcg cttcaacagt tcggttaaat cgattctctc 2692621 gccgattgtg ggcggttttg gcttttcgag atactgctta tcctgctcaa caagcttaaa 2692681 aagtttatat gctgtgagag catcatcaag cgctttatga tgggtgccgg ttccggaatc 2692741 tccatactct tcggcagctt tccataaacc cgtcaatgtc cggtctccaa aaaagttttt 2692801 gtattcaagc gataaatctc tcatttctcc cttaaacggg aaagggatat ggttaaacat 2692861 acagttttgc ttcagcactt tcatatccat gtttccccac gtaataattg tgctgttttt 2692921 ctcaggatcc agctcgttta gtttacggat gaaatcctcg aatctcattc cttcgtctac 2692981 ctgtttttgg gttattttta aaaatgattt gcagcgtttc gtaagcttcg ggaacttttt 2693041 cggtctaaca tagctagaaa acgtctcaac cacttcatca tcaatcgact ttacaattcc 2693101 ggcttcaatg atttccggga agaagttttg aggactgtac tttccatcag gcattgtaaa 2693161 ttcgaaatca ataatgagta agctgtttgt cgtcaccttt tacacctgcc tttcctccga 2693221 tcagaaaatg ctatctttat agtatatcaa ttccccttct cgacatttct tcattttcta 2693281 aaaataatga attttcccag ccgcttcgtt tcttttaaat tgtgaatcgt ttctttataa 2693341 ttagtaagga acccgaaata ataagaaggt gatgttattt ctatccgtaa gaaaaacttt 2693401 gtcattgtgt ggctggcgaa cttttttgtc tccgctagca caacgatgat cgttcctttt 2693461 ctctccttat acattgagac gctcagctct ttttcaaacg gctttgtgca aaggtggagc 2693521 ggctatgtgt tcggcattac atttctcatg gcgtttttgg tatccccgtt ttggggacgg 2693581 ttcggagaca aacgcggata caagaaaatc cttatggcaa ccggaacagg cattgccctc 2693641 agcattttct tcatgggctt tgttacatcg gtgtaccaat tgttttttct gcgtatggca 2693701 atgggtcttg taaccggatt catcccgaca tctcttgcga tgatttcggc acagactccg 2693761 aagagctcag ctggcaaaac actcggcacg ctgcaaatgg ggcaagtgtc cggaagcttg 2693821 ttcggcccgc ttttgggagg catgcttgct gatcgtttcg gctttacgta tacctttttt 2693881 atcacatcct ttgtgatttt ctcgtctgtt cttctcgtgt tatttggtgt caaagaaaag 2693941 catcttgcag agaaaacagc caaacgtacg tcttactcga gaaaagaagt gctctcctat 2694001 atttttcacc atccggcgct gtgggtcatg atgctgttaa ccatgctgat tcaaacaggc 2694061 aatttcagta tccagcccct gctcgcttta tatgtaaatg agctgcacgg acctgtcaat 2694121 cttgcctttt tctccggcat ggcattttca gcaacggggc tcggaagttt gctgctggct 2694181 agaaaatggg gtgatctggg cgaccgctac ggccaccgcc gcattttaat cggacttttg 2694241 ctcgccgcct ctttcttttt tattccgcag gcgctcgcgt cctcactcag cgtgctcctt 2694301 gttttcagat ttttattcgg aatggcgatg ggcggtttgc tgccatgcat tacggcagcg 2694361 atccgcgttc aggctcccgg cagcattcaa ggtgaagttc tcggctacaa tgtcagcttt 2694421 cgctttttag gaaacgtgct cgggcctctg ctcggcggaa tcatatcgag ccattttacc 2694481 atttcggcca ccttttacgt cacggcgttt ctctttttcg ccggcgcctg catgctttgg 2694541 atcatgcaga aacttcggaa agattcttat gccaaagcaa gctgattccg agaaaaaact 2694601 aaggaatctt ctaaatttaa ccttctcgta atctcaaaag aatggtacga tatggctaga 2694661 atttaggaga aaagagagtg accatgttac gaaaaataat cggatggatt ttgctccttt 2694721 gcataatccc attgtttgca tttacagtta tcgcttccgg aaaagaagta aaacaaatga 2694781 agtccctgga tcaggtgctt gataaaaata ttgatctgaa agatatcagc cttgttcaga 2694841 acagctacat gtatgacagg gacggctccc ttgtctcgga aatcgtcagc gaccacgaaa 2694901 accgtgtgct cgttccattt aacaagattc ccgaggaagt caaacagatt ttcttaacat 2694961 ctgaggaccg ccatttttac gagcataaag gctttgactt tatgggaatg gtgcgggcta 2695021 ctgcttctaa cgtaaaagac aagaaaattg accagggtgc cagcaccatc acacagcagc 2695081 tttcaagaaa cttgtatttg agccacgaac gctccttcag ccgcaagctg acagagctcg 2695141 cgtattccta tcagctggag aaaaaatata cgaaaaatga aattcttgaa gcttacttaa 2695201 ataccattta tttcaacaac ggtgtttacg gcgtcggttc agcagctcaa ttctatttca 2695261 gcaaaccgct gaaatctctc acagtgggag aaatggcttt tatctgtgct atacctaata 2695321 accctacatt atatgatcct ctcaagcatt ttgactacac gaaaagccgt caagaacgtt 2695381 tacttaaagg gctaaaagat gccggggtca ttacggacaa agagctgaaa aaagccgtaa 2695441 aacaaaaaat caaactggat gttgaaaaaa gagaagacaa atatcctgac tacgtttcct 2695501 acgtcaatga tgaattcact cagctggtgt ctgaatcaga aggctttgat aaacgccttc 2695561 aaaaagcatc aggaaaacaa aaagaaaaga tcgagaacga gctgtccgca agagtcagca 2695621 cgctgatgaa agacggagtg aaaatttata ctgcacttga tccgtacatg caaaatcaag 2695681 ttgtggcaca aatgaattcc aagctcccgt atgcggacgt acagggcgga gcggctgtga 2695741 ttaatcacca gacgcatcaa atcattgctc tatccggcgg gaaaaactat caaaaatatg 2695801 actttaaccg cgcctaccag gcgtacaggc agccgggttc atccattaag ccgcttcttg 2695861 attacggccc ttatattgaa cagaccggcg cgacaacaag cagcaccatt gatgccagca 2695921 agttttgcag caaagactac tgtccgcaaa actacaataa ccgcacttac ggcacagtga 2695981 cgcttgatac ggcgtttaaa aattcatata ataccccggc tattagaatg ctcgaccgcg 2696041 tcggcatcca aaaggcattc agttatattg agccgtatca ttttgccaaa cttgtcgaca 2696101 gtgactatct tcttccggcg gcgcttggcg gatttacaaa cggcatgacg cctcttgaga 2696161 tgacaaaggc ttatacgaca ttcggaaaca gcggaagcta tacgccgagc catgcgatta 2696221 caaaggtgac agaccttaaa ggaaaaacac tttataaatg gaatgataaa gcgactcaaa 2696281 tattcagcgt ccgcacgaac atgcagctga aaaaactgat gtcttccgtt gtgaaaagcg 2696341 gaacagggaa aaaagcatat ttcaatgcgc cttacatcgg cggtaaaacc ggaacatcaa 2696401 atgattatca cgatatgtgg tttgtcggcc tgactgatac gtatacaatg ggtgtctggg 2696461 tcggaaagga tacaccgacc agcgttgaat atcttcacag catcagccct cagctttcca 2696521 tctggaaagg aacgctgcaa gcggcttatt aaaggatcgg aggggatatg gagtgacttc 2696581 agaacaaatt ccaaatcgcg ttttgctgtt tgacggtgtc tgcaatttat gcaatggcgc 2696641 cgtgcagttt atcattaaac gtgatccgga cggattgatt tctttcacat cgctgcagtc 2696701 ggaaacagga cagagcctgc tgaaaaaaag cgggcttccg actgatcggt ttgacagctt 2696761 tgtctttatt gaagacggcc aagtgtacac aaagtcaact gcagccatta aggttttcag 2696821 gcatctgcga ggcccatggc ggctcttcgt cctttttttc gcagtgccga agcctgtcag 2696881 agatatggtc tattctttca ttgccaaaaa ccgctataag tggtttggca aaaaaaatga 2696941 atgtatgctc ccctcccctt ccattaaaaa aagattttta ccgtaaataa aaaatggcta 2697001 ggaagctagc catcacagat tgttgacaaa atcctaaaac ggcttcgttt taggattttg 2697061 tcatctattc agcgtgattg aaaacttttg aagttgtgaa acggcggaaa cctgagaatc 2697121 tagccgccgt ttcattgcgt acagagcacg aagcgcaaat ctgaccacca aacgctgaaa 2697181 tggctagctt acacaggtaa gctagccatt atgctattat aaagcttgat aaatatgaac 2697241 agaataccga taacaaaggt aaaccaaaac agcagttcca atagaatgaa tccaactaat 2697301 gacatgagag aaagcgtcga ataaatccgg tatacggtaa acacaaagta agcgagcgtg 2697361 acgaccgcaa accagatcac aatccaaatg acattttgca agagcacaaa ggataaaatc 2697421 ccgccgccca aataaatcat ggaacccatt ctgagttttt tcaggttgtt cccttccgga 2697481 tcattagcaa aaaacagcaa tgacagctcg gtcacggtat ttgcaattaa tttcagagcg 2697541 gacagaacca taaaatataa aagtgcaaag gcagcaaata acgcaagcct gattcctttc 2697601 tctgaaaaat aatcgagcat tccatcatac attccaaatg aagacagcat cttcaacgca 2697661 taaagtgaag ttgagatgga taaggacgaa ctaaaaagca ggatcgcaat cagcggaaaa 2697721 tatcctgtca aataagtatt tttcatataa aaaagtccct ttctataatc tacctcattt 2697781 attatggagg acttaaaaca cattgacaag ataaattatt ccattttttc tcctttttac 2697841 gaattacggg cccaaatctt cacaaagcag cattttgaga gtaaagtagt acgcaggaat 2697901 cataaaacgt aaggaagttt tatatgaaaa aaacattaaa actgcaaacc agactcacca 2697961 tatttgtttg tatcgttgta ttaatcgcat tgctcattac gttttttaca gtcggtgccc 2698021 aaaccaccaa acgaattaga gatcaggaaa aggccactgc gctgcagact gctgaaatgg 2698081 tagctgaagc gccgatgaca gccgctgctt tagaaagcgg aaaaaaacaa aaggaactgc 2698141 agagctacac aaagcgggtt cagaaaatta ccggcacgga atttgttgtc gtcatggata 2698201 tgaacggtat ccgcaaaact catcctgacc cgagcaaaat cggaaaaaaa ttcagaggcg 2698261 gtgatgagtc cgaggtatta aaagggcatg tccatatcag cacagcctct ggcacgctcg 2698321 ggaaatcgca gagagcgttc gtccctgtct acgcggagaa tggaaaacag gtcggtgcag 2698381 tcgcggtcgg catcaccgta aatgaaattg atgaagtgat cagccatagc ttacggccgc 2698441 tttactttat tatttgcgtc agcatcttcg tcggtgtgat cggagccgtt atcgtcgccc 2698501 gtacagtgaa aaatatcatg tacggacttg aaccttatga aattgcgact ctgcttgaag 2698561 aacggagcgc gatgctggaa tcgacgaagg aaggaatact cgctgtcgat gaacatggca 2698621 aaattaaact tgccaacgcg gaagcaaaac gcctattcgt caaaatgggc atcaacacaa 2698681 atcccattga tcaggatgta gatgacatct tgccgaaaag ccgcttgaaa aaggtcattg 2698741 agacaaaaaa acctcttcaa gacagagacg tccgcattaa cgggctggag cttgtgttta 2698801 atgaagttcc tatccagctg aaaggacaaa ctgtcggagc gattgcaaca ttccgcgaca 2698861 agaccgaggt aaaacattta gctgaacagc tttccggtgt taaaatgtat gcaaacgcac 2698921 tgagagcgca gtctcatgaa tttatgaaca aactgcatgt gatattaggt ctcgtccagc 2698981 tgaaagagta tgatgatctt ggagattata ttaaagatat agccatacag caaaaatcag 2699041 aaacaagtga aattataaat gatgtcaaaa gctccgtact ggccggtttt ctgcttggaa 2699101 agcaaagctt tatacgtgag cagggcgcaa atcttgatat tgaatgcaac ggtgtcatcc 2699161 cgaacgcggc agacccttct gtcatccatg aacttattac aatcatcgga aatctcatca 2699221 acaatggctt agatgccgtt gccgatatgc cgaaaaaaca aatcaccatg tccatgcgct 2699281 tccataacag catacttgat attgaaatta ccgatactgg agcaggcatg tctgaagaag 2699341 accaagccaa agtatttgaa caaggctatt caacaaaggg caaaaaccgg ggattcggcc 2699401 tttatttcac acagcaaagc atcgaaaatt taaaaggcca aatgatcctc acaagcgaaa 2699461 agaatgaagg aacgacattc agtattcgca tcccgtacga accgaaggag gaaaatcatg 2699521 attaatgtac taatagttga agatgacccc atggtgggtg aattaaataa acgatactta 2699581 agccaaatag atggctttca gctgaaaggc atcgcttctt cctttcaaag cgctctgcat 2699641 attttagggg agcaccatat tgacctcatt ttgcttgata tttatatgcc gggaaaaaac 2699701 gggctggaac tgctgacgga attgagagcc caaaatgaag cggttgacgt gattgtcatc 2699761 tcagcggcca gcgagcttga cgtgatcaag aaaacacttc ggtacggagc tgttgattat 2699821 ttaatcaaac cgtttgaatt tgaacgattc caaacggctc tgtctgatta cagacgaaaa 2699881 caaaaggtgt attcaaccca tcgcaacatg agccaaaaag aactggacgc cgagcttttt 2699941 caaaagaaag aagcaacaga aaaagtgcag cttcctaaag gcctgacaaa aagcacgctg 2700001 aagctgatct ggtccagtat ccagtcattt gaaaatgaat cttttacgac agaagacttg 2700061 gcaaagcaca cagaaatctc tcaagtatcc atacgaaaat acttaaagtt tcttgaagat 2700121 atacaggttc tgaatgtaga aatggcgtac ggaacgatcg gaagacctgt gtttcagtac 2700181 aacgtcaaca acagtaacat taacggaata aagcaatatc tataagaaaa cgcactgctt 2700241 gctttgagca gtgcgttttt ctgtcatatc tcttgccaag atgcttgatt ctattgttga 2700301 taagttatac aagaataaca aagggctttc acatttttaa gcaaataatt ctaaaaatag 2700361 ataattttta aaaaattatg cgaaattcta tttatttctt attagttaaa tgataaatta 2700421 tgattggtta gttgatcccg aaaaactaag tcataagtct tacttcagaa aacgatgtca 2700481 cggttttccg cccggaacgc cttccgcatc cttctcttcc ccgcctttcg aaggaaatac 2700541 tcacaccacg cttattcagg gaagaataga actgtctcag cgcattccat ttgttattat 2700601 cagaaaattt tatcgattct aagaaattgt tcaggacagc ccatcacatg actggccgga 2700661 tcagctttga accaaatttt tctggggggt tatatcttga ataaacgaaa aatcggattg 2700721 gcgatgtcac ttgtgatcgc agcaggcacc atattaggag catgcggaaa cagcgaaaaa 2700781 agcagcggct caggcgaagg caaaaacaaa ttcagtgtgg cgatggttac tgacgtaggc 2700841 ggagtggatg acaaatcctt caaccaatca gcctgggaag gcatccaagc ctttgggaaa 2700901 gagaatgggc tgaaaaaagg caaaaacggt tacgactatc ttcaatccaa atctgatgca 2700961 gactatacaa cgaacttaaa taaattggcg cgtgagaatt ttgacttaat ttacggcgtc 2701021 ggctacttaa tggaggattc aatcagcgaa attgctgacc agcgtaaaaa tacaaacttt 2701081 gcgattatag atgctgttgt cgataaagac aacgtcgcaa gtattacgtt taaagagcag 2701141 gaaggctcat ttctcgtcgg agtggccgca gccctatcaa gcaaatcagg aaaaatcggc 2701201 tttgtaggcg gcatggaatc agagttgatc aaaaaattcg aggtcggctt ccgtgccggc 2701261 gtgcaagcag ttaaccctaa agccgttgta gaagtgaaat acgcaggggg tttcgataaa 2701321 gccgatgtcg gtaaagcaac cgccgaaagc atgtataaat caggcgtaga tgttatttat 2701381 cactctgcgg gcgccactgg cacaggcgtc tttactgaag cgaaaaacct gaaaaaagaa 2701441 gatccaaaac gcgatgtctg ggtcatcggt gtcgataaag accaatacgc agaaggccag 2701501 gtagaaggaa cagatgataa cgtcaccctc acttccatgg tgaaaaaagt agatacagtc 2701561 gttgaagatg taacgaaaaa agcgagtgac ggaaagttcc cgggcggcga aacacttacc 2701621 tacgggcttg atcaagacgg agtcggcatt tctccatcta aacaaaatct atcggatgat 2701681 gtgatcaaag cggtcgataa atggaagaaa aaaatcatcg acggattgga aatcccggca 2701741 actgagaaag agctgaaaac cttcaaagct gaataagaat cgcagggata aggaggtcga 2701801 gcccttatcc cttgtttttc ttttattttg aaataaagga gcggtcaatc aatggaatat 2701861 gtcattgaaa tgctcaatat ccgcaaggcg tttccaggta tcgtcgccaa tgacaatatc 2701921 aatcttcaag tcaaaaaagg cgaaatacac gcgttgctcg gtgaaaacgg agcggggaaa 2701981 tcaacattga tgaatgtcct tttcgggctg tatcagccgg agcggggtga aattcgggtg 2702041 cgcggcgaga aggtgcacat caacagcccg aacaaagcga atgaccttgg aattggaatg 2702101 gtgcaccagc actttatgct tgttgacacc tttacagttg ctgaaaatat tattctcggg 2702161 aaggagccaa agaagtttgg cagaattgac cggaagcgtg ctggccaaga ggtgcaggac 2702221 atttccgatc gatacggcct gcagatccat cctgaagcaa aagcagctga catatcagtc 2702281 ggtatgcagc agcgcgcaga aatattaaaa accctctacc gcggtgccga cattctgatt 2702341 tttgatgaac cgacggctgt tttgacgcct catgaaatta aggaactgat gcaaattatg 2702401 aagaacctgg tcaaagaagg gaagtccatc atcttaatca cccataagct gaaagagatt 2702461 atggagattt gtgaccgcgt tacggttatc cgtaaaggaa aaggcatcaa aacccttgat 2702521 gtccgtgata caaaccaaga cgaactcgcc agtctaatgg tcggccgtga ggtatcgttc 2702581 aaaactgaaa agagagctgc tcagccggga gcggaagtgc ttgcgattga cggcataact 2702641 gtaaaggata cccgcggaat agagacagtc agagatttgt ctctttctgt caaagcggga 2702701 gaaatagtcg gcatagcagg cgtcgacgga aacgggcaat ctgagctgat cgaagcggtg 2702761 acaggactcc gcaaaacaga ttcaggaaca atcaccttaa acggaaaaca gatccaaaac 2702821 ctgacgccaa gaaaaatcac tgaatccggg atcgggcata ttcctcagga tcgccataaa 2702881 cacggtctcg tccttgattt tccaatcgga gagaatatcc tgctgcaaag ctattacaaa 2702941 aagccgtatt cagcattggg cgttttacat aaaggcgaaa tgtacaaaaa agcacgcagc 2703001 ctgatcactg agtacgatgt cagaacgccg gatgaatata cacacgctcg ggcattgtca 2703061 ggcggaaacc agcaaaaagc gattatcggg cgggaaatag accgaaatcc tgatttatta 2703121 attgccgccc agccgactcg cggccttgat gtcggagcga ttgaatttgt ccataaaaag 2703181 ctcattgagc agcgtgatgc cgggaaagcc gttcttctcc tctcgtttga gcttgaagaa 2703241 attatgaatc tcagtgacag aatcgccgtt atttttgaag gacgcattat cgccagcgtt 2703301 aatccgcagg aaaccactga acaggagctt ggtctcttga tggcaggaag cacgcaaaag 2703361 gaagcgggga aagcaaatgg ttaaacgact ctctcattta ctcgtgccgc tcatcgcaat 2703421 catacttggt cttgcggccg gcgcgttgat tatgcttgtg agcggctaca gtgtggctag 2703481 cggatattcg gctttgtgga atgggatatt cggagaaatc tattatgtcg gagaaacaat 2703541 ccggcaaatt acgccttata ttttatccgg attggctgtc gcctttgcat tccgaaccgg 2703601 actctttaat atcggcgtcg agggacagct gctcgtcggc tggacagcag cggtttgggt 2703661 cggtacggcg tttgacggac cggcatatat tcacttgccg ctcgcattga ttacagcggc 2703721 agctgcagga ggattatggg ggtttattcc cggcattttg aaagcgcgat tttacgttca 2703781 tgaagtcatt gtcaccatta tgatgaatta tatcgcgctg cacatgacca attacatcat 2703841 ttcaaacgtc ttgacagatc atcaggacaa gacggggaaa attcacgaat ccgcctccct 2703901 ccgctctcct tttcttgaac agatcaccga ttactcacgg ctgcatttgg gaatcatcgt 2703961 tgcccttctc gcagcagtta tcatgtggtt tatcatcaac aaatctacaa aaggatttga 2704021 gctccgggcg gtcgggttta accagcacgc ttcccagtat gccggcatga gcgtgcggaa 2704081 gaatatcatg acctccatgc ttatctccgg cgcttttgca ggtcttgccg gagccatgga 2704141 gggcctaggg acattcgaat acgcagcagt gaaaggcgca tttaccggcg taggctttga 2704201 cggtatcgct gtcgctcttc tcgggggaaa cacagccgta ggcgttgtac tggcagcatg 2704261 cctgcttggc gggctgaaaa tcggcgcatt aaatatgccg attgaatcag gcgttccatc 2704321 agaggtcgtt gatattgtga ttgccattat tattctattt gtggcttcaa gctatgcgat 2704381 tcgtttcgtc atgggcaaat tgaagaaaaa gggggcgaac taagtggaca ttgtgcagat 2704441 tttatctatc attgtccctg ccacactcgt ctatgcggcc ccgcttattt taactgctct 2704501 cggcggcgtg ttttccgaga gatcaggtgt ggtgaatatc ggcctagaag gcctcatgat 2704561 tatcggggcg ttcaccagcg tgttatttaa tttatttttt ggtcaggaat taggtgccgc 2704621 cgcaccttgg ctttcgctcc ttgccgccat ggcagcaggc gccctgtttt cactgattca 2704681 cgcggcagcg gcgatttcgt ttcgcgccga ccagacagtc agcggtgtcg ccattaacat 2704741 gctggcgctt ggggcaactt tatttatcgt caaactgatc tacggcaaag cgcagacaga 2704801 caaaattcca gagccttttt ataagacgaa aatccccggt ttgggcgata ttcccgtctt 2704861 gggaaagatc ttcttttcgg atgtctatta tacgtctatt cttgcaatag cacttgcctt 2704921 tatttcctgg tttatcttgt tcaaaacgcc gttcggcctt cgtatccgtt ctgtcggcga 2704981 gcatccgatg gcggccgata cgatgggaat caacgtatat aaaatgcgct acatcggcgt 2705041 gatgatcagc ggattgttcg gcggtctcgg cggcggcgta tatgcctcca caattgcgct 2705101 tgatttcacg cactctacca tctccgggca aggttttatc gccctggcag cgcttgtatt 2705161 cggaaaatgg catccgatcg gagcactggg ggccgccctg tttttcggat tcgcccaaag 2705221 cttaagcatc attggatcgc tgctccctct ttttaaagac ataccaaatg tgtatatgct 2705281 gatggctcct tatatcttaa cgattctcgc tttaaccggc tttatcgggc gggcagatgc 2705341 gccaaaagcc aatggcgtgc cttatattaa aggaaaaaga taaacattct cccctgggaa 2705401 gacgattctc agggattttt ttctaatcca aaagaccccc ttaatttaat tgtttattag 2705461 ttttttaact taaaaaaata tgaagtgtta acgctttctt gtagactgta acaaacaata 2705521 catgggggtg tatgacatgg gagcaattcc aaaaacgggg acaatttcac ctgagcaaaa 2705581 agactcacag gagaaaaacc tgtttcaaaa aatttggtct tgggaaatcg gtgtgattcc 2705641 tttgccatta tacacagtat tagctgttat tattattctt gcagcatatt acaatgagct 2705701 gccggcaaat atgcttggcg ggtttgccat cattatgatt cttggtgtgt ttctcggaga 2705761 cataggccaa cgcataccga tattgaagga tattggcggc cctgctattt tatctttgtt 2705821 tgttccttca tttttagtct tttacaatgt actgaattca acatctttag acgctgtaac 2705881 caacttgatg aaaacgtcta acttccttta tttctatatc gcttgccttg ttgtgggaag 2705941 tatcctcggt atgaacagaa ttgttttaat acaggggttt atcagaatgt tcgttccact 2706001 ggttgcagga acgatcgcgg ccgttgcagc cggcatcctt gtcggattta tttttggcta 2706061 tagtgcctat gattcctttt tctttgttgt tgtcccgatt attgccgggg gaataggtga 2706121 agggattttg ccgctttcaa tcgcctattc acaaatactg ggctcatccg ccgatgtatt 2706181 tgtgtctcag ctggtgccag ccgcaattat aggaaacgtt tttgctatca tatgtgcagc 2706241 cttaatgaaa aagcttggcg acaagcgtcc agatctaaat gggaacggac gtctcgtaaa 2706301 atctaaaaaa gcaaatgaga ttttcaatca aaaagaagcc gaagcaaaaa ttgattttaa 2706361 actaatggga gcaggagttc tgctcgcgtg tacattcttt atttttggcg ggttattgga 2706421 gaaattcatc ttcatcccgg gcgcgatctt aatgattatt tcagctgcgg ctgtcaagta 2706481 tgcaaatatt cttccgaaaa aaatggaaga aggcgcttac cagctttata agtttatttc 2706541 ttcaagcttt acatggccgc tgatggtcgg tctcggcatc ctctttattc cgttggatga 2706601 cgtagcgtct gtgatttcta taccgtttgt catcatctgt atttcagttg ttatcgcgat 2706661 gattggttct ggatatttcg taggcaagct gatgaacatg tatccggttg aatccgcaat 2706721 cgttacctgc tgccacagcg gtctcggcgg aacgggtgat gttgccattt tatcggcatc 2706781 aggaagaatg ggccttatgc cgtttgccca aatttcaacc cgtctcggcg gtgcaggcac 2706841 agttatttgc gcgacagtgc tgcttcgttt tttcacttca taaacagaaa gagttccgtt 2706901 ttatgcggaa ctcttttttt atttattcac aatccgaata tactctcggg gaccaaacgg 2706961 cagatccttt gattccgtct cactcattct ggctgacagg tggtgctcca gtaaatacag 2707021 ctcccactca tcacaagccg ccacaccgct gcgcccgtca tattgattca acatgaatgc 2707081 ccctgcaaat actgagcaga ataaacctga gcacatcacg acttttgttt tcacatgacc 2707141 agctcctttc cttcagcttg atcaggattg attttaaata tacaaataac ctcttttttg 2707201 ttagacttat tttgaggtca aaagaactca taaaaatcca ttacagcagt tcgaagcgtg 2707261 gcagcttgca gaaaagtgcg atataatttg gactaggtcg tttgaccgta tattttatac 2707321 atagcgcatt tttcaattga gaacgagaaa aggaggtctt atctttgcag ctcttacatc 2707381 ttgctatttt atcgcctttt ttatttgctt ttatcattcc cttcttggca aaatacgcaa 2707441 aaagagtgca tacgggctgg tttgtgttga tcctgcccgt cttgctgttt atatactttc 2707501 tcccaatgat caggatgacg caatctggag aaacacttcg atcggtatta gagtggattc 2707561 cgtcactcgg cattaacttt accgtttata tagacggcct cgggttatta ttcgctttac 2707621 tgatcacagg cattggctct ttggtcactc tttacagcat tttttattta tcgaaagaaa 2707681 aagaacagct tgggcccttt tatgtctact tattgatgtt catgggcgcc atgctcggcg 2707741 tcgttctagt agacaatgtc atggttctct acatgttctg ggagcttaca agcctttcat 2707801 cctttttgct gatcggctat tggtataagc gggaaaagtc gcgctatggc gcagccaaat 2707861 cacttttgat tacggtcagc ggcgggctgt gcatgctcgg cggatttatt ctcctttatt 2707921 tgataacgga ttccttcagt attcgagaga tggttcacca ggttcaatta attgccggcc 2707981 acgaattgtt tatcccggct atgattctca ttttattagg ggcttttacg aaatcggcgc 2708041 aatttccttt ttacatctgg ctccctgacg cgatggaagc tccgacgcct gtcagcgctt 2708101 atctccattc agctactatg gtaaaagccg gcatttatgt gattgcgaga ttcagtccta 2708161 ttttcgcctt ttcagctcag tggttttgga tcgtgtccct cgtcggcctc tttacgatgg 2708221 tttggggttc attccatgcc gtgaaacaaa ctgatttaaa atcgattttg gcgttttcaa 2708281 ccgtcagcca gctcggcatg atcatctcca tgctcggagt cagtgctgcg gcccttcatt 2708341 acggacatac agaatattat acagttgccg ctatggctgc cattttccat ttgatcaacc 2708401 acgcaacctt taaaggaagc ttgtttatgg cagtcgggat tatcgatcac gaaacaggca 2708461 cacgggatat ccggaagcta ggcggcctga tggcgattat gccgattact tttaccattt 2708521 ccttaatcgg gacattttca atggccggcc taccgccgtt taacggattt ttgagtaaag 2708581 aaatgttttt cacaagcatg cttcgcgtga cacattttga cctgttcaac gtgcagacat 2708641 ggggcgttct gttccctctt ttcgcctgga tcggaagtgt atttacgttt atctacagca 2708701 tgaaattgct gtttaaaaca ttcagaggaa attaccagcc tgaacagctt gaaaaacagg 2708761 ctcacgaagc gcctgtcggt atgctcgttc caccggtcat tcttgtcgct ttggctgtca 2708821 gtctcttctt tttcccgaat atattgtcgt acagcctgat agagcctgcg atgaactcaa 2708881 tctatccgac actgcttgac ggccatgaga aattccacgt tcacatttca cagtggcatg 2708941 gggttacaac ggaattgctc atgactgcgg gtattgttgt gatcggaaca attggttatt 2709001 tgtcgctgaa taagtggaaa ggaatctata aactgtttcc ttcgaaactc acactcaacc 2709061 ggttatacga taagcttttg actatgatgg agaaaggctc ttaccgggtc acaaaacaat 2709121 atatgaccgg gtttttaaga gattatttgc tgtatatctt cgctggtttc atcattctga 2709181 taggcggagc ttttgccatt aaaggcggat tttcatttaa aacggaaggc atggctaaaa 2709241 tcggtgtata cgaaatcatt ttgacgcttg tcatgatcag cgccacagtg gcgactgttt 2709301 ttgctaggtc aagactgacg gcgatcattg cactcggtgt tgtcggttat acgcttgcat 2709361 tgttttttgt cattttcaga gcgccggact tggcattgac tcagctcgtc attgaaacga 2709421 tttctgtggc actgtttctg ctttgcttct accatttgcc gaaactgagg ctgaaaacaa 2709481 aaacgagaac gttccggatg acgaatttta tcatttcttt aggcgtcggt gttatcgtta 2709541 cactgctcgg catcgcatcc tcaagccagc ggacaaaaga cagcattgcg tccttctttg 2709601 tcaaacacag ccacgatctc ggcggagggg ataatgtcgt caatgtcatt ctcgttgatt 2709661 tcaggggatt tgatacaatg tttgaaatta cggtattaac gatagccgct ctcggcattt 2709721 acagcatgat taaaacaaaa gtaaaagagg aggggaaaag cggtgaatga acaaaaaaca 2709781 aatgacttga ttcttcaaac cgcgacaaag cttgtatcct ttatcatttt gcttttctct 2709841 ttctatttat ttttatcagg gcataacgcg cccggaggag gctttgtcgg cggactgatc 2709901 acgtcctctt ccatcgttct cttgctcttg gcatatgatt taaaaaccgt gcgttccctt 2709961 ttgcctgtca atttcattta tgtcgcggga gccggccttc tgctcgctgt attaacaggc 2710021 gttggctcct ttgtcttcgg ggctcctttt ttaacccaca cattcggata ctttcagctg 2710081 ccgatccttg ggaaaacgga gctcgccaca gcgacgatat ttgatttagg cgtttatctt 2710141 gttgtcgtag gcataacgat gaccattatt caaacgattg gagaggaaga ataatggaaa 2710201 tcttaatggc tgtattagcc ggtattattt ttatggctgc tacgtatttg ctgctgtcta 2710261 aaagcctgct tcgcgtcatt atcggaacag cactgttaag ccatggcgtt catttaatgc 2710321 ttttgactat gggaggatta aagaaaggcg ccgctccgat tttgagcgag catgccaaat 2710381 catttgtcga tccgcttccg caagccctga ttttgaccgc aattgtcatt tcttttggcg 2710441 ttacgtcatt catcctcgtc atggcctttc gcgcttatca ggaattgaaa tcggacgata 2710501 tggatcaaat gaggggaaat gatcaacatg aataattttg ttattttgcc aatcctgatc 2710561 ccgcttttgt cggctattct tctgattttc atgacgaaga atcttatgct catgagaatc 2710621 ttcagcacgg cggcatcggc catcgggatt gtgattagcg gcatacttgt acagactgtc 2710681 ttcacaaaag gcatccagac actcagccta ggcggatgga aagcgccgta cggcattgtg 2710741 cttgccgcag accaattcgc cagccttctc gttctcacaa cagcgatcat cggtttattg 2710801 gttgggcttt attccttccg ttctgtcggt gaaaaacggg agcgctcctt ttactactcc 2710861 ggcgttcagt tcttgcttgc cggcgtcagc ggagcgtttt taacaggcga tttatttaat 2710921 atgtacgtat tttttgagct tctgcttatt gcttcctata tgctgattgt attaggcggc 2710981 acaaaaattc agctgcggga atcccttaaa tatattgtgt ttaatattgt atcgtctgcc 2711041 ctgtttgtca taggggtcgg ctttttatac gctgtaaccg gtacgttaaa catggcggat 2711101 cttagcgtga aaatcagcga atcaggacaa accgggctga tcactgtgat tggtgtcctg 2711161 ctgcttttgg tatttggcat gaagggcgga atcttccccc tctacttttg gcttccaggc 2711221 tcttattacg cgccaccggc ggcaatctcc gcgttgttcg gcgctttgct gacaaaagtc 2711281 gggttatatg cgattacgag ggttttcaca ttgattttta ttcacgatac agcctttacc 2711341 catcagttga tgatttggct ggcggcgctg actgtgattt ttggtgtgat cggttcactc 2711401 gcttattcga atgtcatgaa aattgtgatc tataacatta ttaccgctgt cggcgtgatt 2711461 ttgttcggtg tggcagtaca cacccccgca tccattcagg gcgcgatcta ctatctgatt 2711521 cacgatatgc tgattaaggg cgctttgttc atgctggcag gtacgctgat cgcattgact 2711581 ggaaccgcga gcctgcataa aatgggcggg ctgatcaaac gctatcctgt tcttggatgg 2711641 atgtttttca tttccgctat ttctcttgca ggcattccgc cactgagcgg atttgtcggc 2711701 aaatttaaaa ttgcagaggg cggcttcgca gaaggtgaat ttacgatatc catgctgatt 2711761 ctgctttcga gtctgcttgt actgtactct gtgctgagga tctttataca tgcgttttgg 2711821 ggcgaagaaa aagaaacgcc aaaaccaaat catcgaacag ctaaaggact tctttatccg 2711881 gcagctattt ttctcttgct gtcccttctc ttcggattgg gtacagaatg ggtgtcgcct 2711941 tacgttgatc aagcggccga gacgctgctg aatccggaaa aatatatcga agctgttctg 2712001 aaggagtaga tcgcatggca tttcaaattt tattaaatgt gtttctcgct ttttgctgga 2712061 tgttcttaag caacagtcca agcgccgcag gattcattac aggctatatt ctgggaatgc 2712121 tctctctctt tttcttccgg cgctttttca ctcgccagtt ttatctatgg aaattgattt 2712181 ctattatcaa gctctgtttc atttttataa aggaactgta ccttgccaat gtcagtgtga 2712241 tgaaatcagt cttatctcca aaactgaata tcagaccggg tatttttgct tttaaaactg 2712301 aactgacgaa ggactgggaa atcaccatgc tttctctgct cattacatta acgccgggaa 2712361 ccttggtgat ggatatttca gatgacagaa caatacttta tattcatgca atggatatcg 2712421 aggatgcgga aaaagcgatt tttgacattc gggagtcatt tgaaaaagcc atacaggagg 2712481 tgagccggtg atgtttacgc tgatcctgca aatcgcgctc ggcattatgg cagtgtctac 2712541 ctttttgtat gtcattcgtg tcattaaagg tccgactgtg cctgaccggg tcgtggctct 2712601 ggatgcaatc ggcatcaatc tgatcgcaat cacggcgctt gtctccattt tgctgaaaac 2712661 aagtgcgttt ttggatatta ttttgttgct ggggatttta tcgtttatcg gaacgatcgc 2712721 attttccaag ttcctggaga aaggagagat tatcgaaaat gatcgaaacc gctaaggtcg 2712781 ttgtggctgt attcattttg ctgggtgctc ttatatgcct cattgcttca tttggcgtac 2712841 ttcgccttcc cgatgtgttt acacgcgctc atgctgcttc taaaggctca acattaggtg 2712901 tcaatatgat tctgctcggt gtcttcttct atttgtggtt tgtgacgggg gagctctccg 2712961 ctaaaatcct gcttgggatt ctctttatct ttattacgtc gcctatcggc gggcacttga 2713021 tctgccgtgc tgcgtataac tccggcgtca agcttgatga gagaagtgtg caagatgact 2713081 ataacggaat cagaaacttt gtgattaaac gaaaagagga ttcttattta taaaaataag 2713141 cagccggaca ggcagagttc cggctgtttt tttatttctt gatgacagcc agcgtgcatc 2713201 tggatataca gatcagcctc tcttgctcgt catatatgtg aatatgatag acaatcgtcg 2713261 ttctgcctat atgaacgggc tcggctatcg cctttaccgt tccttccttt acagatttta 2713321 aatggttggc gttaatctcc aaaccaacac aagcttgcgt tgtatgatca atcaggttct 2713381 gtgcacctgc gctcgccgcg gtttccgcca gggccactga agcgcctcca tgcaaatatc 2713441 cgaacggctg taccgtccga tgatccaccg gcatgaccgc aacgcatcgt tccgctgtgt 2713501 tttcaacaat ctcaatacca agcgcttcaa gcaatgtgtg cttcatatcc atctctacac 2713561 cccccaacat ttaaagtaca ccgtctgatt tcgcaatcaa aaccgcttcc gtccgtgaac 2713621 cgacattcag cttattgaaa atcgatgtca agctgtattc aatggaccgc ttgcttaaat 2713681 gaagggcatc tgcgatttct tggtttgtaa atcccttttc aacttcttga agaatcaggc 2713741 attctctagg tgtgagcaca tcttgttctt tttgagagga aggagccggc tttgtttttt 2713801 gctgagtcat cagctgttta aagtaagcaa aatcgactaa aatttctccg ttgagtacgt 2713861 ggtatatgta ttgggtgatc ttttctttag attccgtttt gctgatggca ccgtgcagac 2713921 ccgcacgaat cgcttcctcg aaataatcct cgacctcata accggtatac acgataattt 2713981 tacaatgagg attctcttgt aaaatctgtt tagaaagctc catcccattg acctcgccgc 2714041 ctagattcag atccattaaa atgagatcat atgacgagaa atcatgctgc ttgataaact 2714101 gttcgctcgg ttcaggactg agacaatcaa cagacaaatt cgaatccgtt tccaaaattg 2714161 tcttggtgcc ttccatgaca gccggatggt catcaatcac tagtatcttt ttcatgtttt 2714221 cctccctttt actcactctt ttccatttta taaaaaagac ttggcctgtg ccaagtcgtt 2714281 tccgttataa atccattaca attcgatttc aatatcagcc ttaaagccct ttccttcact 2714341 tgtttcaatc cgaaggcgcc catctaaagc cctgactctc tccttaatgc cagaaagccc 2714401 catgctcatg gaatgctcag tatttttttc ttgatcaaac ccaacgccat cgtcctcata 2714461 atgaagaacg attttgtttt gaatactgat gagcataatc agcacatccg tcgcctgaga 2714521 gtgcttgacc gcattagaca gaaactcttg aatgatccgg tacaaattca gctgcgaatc 2714581 cagatcaagg gaagccgtaa atctcccggt atttaaacgg atatgaaacg gaacccgctc 2714641 ctgctgctgc gccaccagct tcgacagcgc cttcaccaat ccaagatcat acagaagctg 2714701 cggccgcagc tcatgacacg tctccctcgt catcgaaatc acatcagaca tctgctcatt 2714761 catctgtaca agcttgtcct gcacctcttc acggcacgga ttatcatcct tcttgaaatc 2714821 acccaaaaac agctcacact ggcgttttaa ggaaatcaaa tcctgaagaa ccgaatcgtg 2714881 gagatcgcgg gcgagtcctg aacgctgttt ttcttcgatt gcaaacatta gctttttcag 2714941 ccagatgggg ttggttccct cttgttttaa gtccttcaaa tgttccatga gctcctcaat 2715001 atgcaggaca ttttccatgg acacacttgt ataaaaagac agtgttttca gccacgatat 2715061 ttcatcacgt gttagccggg gagtgttaat attagataaa caaagcagaa cataagaact 2715121 accgcctcgt tcaccaactt tcataagaaa gccttgattg acttctataa ttttcccaat 2715181 ttctgaagtt acgttttcaa attcctcttg ataaaaattc cagtccggtc caacttcatg 2715241 cttatctaaa aatatcactt tgtgatcagg agtaacctca aaggtataag ctttgcttac 2715301 aagcaaaaca tccagtatag tatttttcag ttctttaaaa acttgttgaa gagaagttac 2715361 acccctcatt agctgagtat atttaaaaat actgtcctga tagttgaatt tttcggagaa 2715421 acgttttaac cgaaatttaa aatccatgac ctctttaaaa taaaagacag cgaacatgac 2715481 aacgaaaaaa aatacagttt gacgcacagg gttcatctgg atgtccatta catcaaacag 2715541 aactaatgca ccaactatta gaagagttgg tatcatggca agtagagcat agtatctcat 2715601 tcttcctaag ataaactcta tatcaaacat cttattggct acaaattggt atactaaccc 2715661 gaacggaatt agtactagta atgacgccga agctaatgcc gggaaaatat aattacctgt 2715721 aaatattatt ggaagaacaa aaaatatcaa aaaaggcgca aatgaaagag tgtttgttaa 2715781 aattagtaat ttaagaataa acgaatgctc agcatattta tatttattaa gatgtaagta 2715841 tatcgctgaa aaagaaaata gagtcaaagt tgcaaaagaa accaaattaa gagttgctaa 2715901 aaaatcaata tctacttgta aatagtcttg aaaaaactca ataccaagat taaatattgg 2715961 tatgatataa agaaaagaaa ttctattcaa aaaagtttta cctatttctc caaggtatct 2716021 ttgtataaat tgaagataaa gaataggaga agatataaaa gtaaacaagt taatataccg 2716081 attgattata tgtcctctaa atggtccgcc tgcacttata tatgctatcg aaatgtctaa 2716141 taacaataga ataagaatat aggcagcaaa tgatctcctt tttttattta ctttaagtat 2716201 ataaaaaata catattatgc ttaaaaaata aaaaaacaaa ggaagtacga acagaaaaaa 2716261 actataaggt ctatttagag taactaaatc aaaatctttg agatgaatct tttttccact 2716321 tctcaaaata tccagactgt taatatgact caaatatccc catttcaaat gtttgtctga 2716381 aggtttttct ttattaattt ttaatatgat gtctccctgt ctcagaccaa caaattgtcc 2716441 atatgaagat tccgatattt cttctatcat aaattgactt ttatcatttt tatgaatctt 2716501 agtcccaata ataattccat tcatactgat ataagttgta tagcttatat aaaggatact 2716561 caaaacaatt acagctattg tgaatttttt tattaagttc ttcaatatta atccacctat 2716621 taatcacccc attgacgggt tattggatca gccagataat aatcattata agctttaatt 2716681 attgtttcag tttcttgcac atcaaaacct ataaggcagg cttctttatt tttcaatttt 2716741 tttaaagcct caggataatt taaaaagtag ttaattaggt cttgcatctt gtatccccct 2716801 ttgtataact taataagcat tcctttatta gctctttttt tctttatcta aatttaattg 2716861 ttctatagca gaaatacatt tctgtttata tatttccaat aataccgaaa tgtattgagt 2716921 aactcccgct ttaattaatt tttcttggaa tttctcttta tcaagtaacg atttataata 2716981 taagtcttta tgtgaaatta agtataataa atcttccgaa gcatcattaa aaaggcgctt 2717041 aagatataag taaatcagtg tatgtttgtt tttttcaata tcactgcgat ttccggataa 2717101 aagaacataa taatctccag aaatttgagc tataatccct ttatagtagg aatatctttc 2717161 aactgtttca ttatattctc ctgtagccaa taaaacacct gctacatttg ctagtgcaat 2717221 cagacttcca cattttaatc taattacttc taaactttca tcttctgttt tagatttatt 2717281 agtgatatcg tcatgttgac cttgcatggc ctcgtttacg tattttaaaa catatttaaa 2717341 aattagagga ttgttattta atgaataaat actcgttaat cctactgtat acaaggaaag 2717401 tgctgcattt aacgactccg agcgattaat tttcatccat aatgcatggt gattatcttc 2717461 atcttcaaga tcatccataa tatctgatga aagaataaga atttctattc ccgcgccaag 2717521 ccttgttgca acatctaaat tctcccctcc aaaaacaaca taatgtaaga ttgtggattc 2717581 agcaaaggag aatgtttctt tagaatcaat aaatgagtaa agaagttgtg acaaatcctc 2717641 gttaaatatg ttttgctcca caatctcctt cattttctcc ttgatccgga cagaatctaa 2717701 acatatctgc tcaataacga cttcccccct cccattccat tttactaaat gggacattta 2717761 aaggacagca ggtttttcgt tttttaacaa tcatataata ctttatccat ttattgtatc 2717821 ggtagaacga aaaaaaagac ttgtttccaa gtctttttca cgaaattttc attgcataat 2717881 tgtatttatc gagttgatca atgcttttgt taatgtttcg taatgaatct gtcgtttctt 2717941 taatatcaag ttcgagtcgg aataacaatt gttttacttc ttcaagtttc ttttccatcg 2718001 tttccacact cctttttttg aaagatcaat gaattgtgta tggtgaacga gtcctaggta 2718061 tttgatctgt tactaatagt gtgtctgctt tcggctcatt tttcaccgaa aagtatgcaa 2718121 aaaagtcctg cgtgacaccg caaatctcaa taggtcctta tactcaaagg aatcacaaca 2718181 agaacgggac tatctttcta tgcgaaagag cgtttatatg tgctgaaatt gagaaagatt 2718241 cttaatctcc ttgattttaa cgggtttcgc attttcacta agcaagacta tagtccttca 2718301 taccgtattt tcaaaattga atatgcgatt cttggcgttt cctgaccgac aaacaccgaa 2718361 aaagaccgca acgctaaagt tgtggccttt tcgctttgtc atattcggca attagggatc 2718421 tatacatata gaaacatcct tttttgcgag gtgctcccat gagatatcgt tatccctggt 2718481 tttacgtgta tccgtatgag gtacgccgtc cgcccgctcc tgccaacaat attgatacct 2718541 ttatccgttc agcgaagcag gccgcaggga tatttgcgga tgcccagctc gttctcagcc 2718601 gcattgcggg ctcgcgggag ctttcgcgcc gcattctgac cgcagccgaa cagtctgata 2718661 aacaaactat aaggcgcctg atcaaacaaa tgggcgtccg gcatgaagtg gatacggtct 2718721 ttaatcccga cggcatctat atcagcctta tcggaacgca aagccgaatg attcttgctt 2718781 tgcggtggtc agaggaccgc aatcattttg cgtccataag attatgacac cattccagag 2718841 cctctaaata acattcatac gcttcttctt tgtccagttg attgcctaat tctgagcaag 2718901 tgtcccagtt gttgctttca attaatttca caagctcaag catttggtag tagtcgtttt 2718961 gatggcctaa taatgcttgc ccgacttcat cttttaaagg caattcttga acaatttcct 2719021 ctatttctct atgcaggagg gtgtctatga gagaaaacat tccgatcagc atataagaag 2719081 caggctgcgg ccgggatgtc tttctcgcca gcagttcgca aagctttgct cttatcagag 2719141 aaatcttaat gatttcgtgc ttgctggaat gccctttcct gcttaaatcc ttaaaggaaa 2719201 gaatatatat ccaccgtttg atttcattaa atcccagcag cataatggcc tgttgaatgc 2719261 tttcaatttt ctggctcaaa cggctgtggg atgagtttaa aaattttaaa atttgatagg 2719321 acagtgataa atcccgctct atgtactctg tcacacgctt tatgttaggc tgctctttac 2719381 tcagttcgtt aagcagttca tagtaagaat agaaatgagt cgataggtca tgcccgctga 2719441 tgatgcgcgg ctcgctgaaa aagtagcctt ggaataattg aaagccgtct tggaccgcct 2719501 gtttatattc ttttcgggtc tctacttttt ccgctaaaaa aatcaggccg cggcagccgt 2719561 aggtttgcaa aattgttctg cgttccattc gtgttgtttt gagaaaatca attttcaata 2719621 tatcaatata gctcatgagt ttttccagta agtcctcatc ttgcggattt attgcataaa 2719681 aatcatcaag cgccagcata taccccattt ttttcaattc tttgcatcta gaaatgaggg 2719741 ccggcgtgat cggtatatct tcaaggattt caatgacaag ctgtttcgga ttgaaggagg 2719801 tgggaagatt cgaaaacatc aggctttccg taaaattaac aaaacagcgt ttcccttccg 2719861 tcagcttctc aattccgatg tttaaaaagc tgttgatcac caaatctgtt gttgcctgat 2719921 cgccgtcttt agcgctatac acgttctctt cgctttctct atacagcagt tcataagcaa 2719981 caacctgttc ttttctatta aaaataggct gtcttgcaac aaacaccctc attgatttat 2720041 cccccttaca atacgcgcgg ctttcacccc taagtatatc aaataatttg acgaaaattg 2720101 tctaaacatg aaaaataata tatacataaa gaaaactggc ccttcgcgaa tgaaaggcca 2720161 gtttttcttt attcttcctc aagctcttct tcaattctgc ttttcacttc gtggatccgc 2720221 tgcattttat tgctccagca gtcctcgctt aaatcaaccg ggtattcctc cggcttgctg 2720281 attctcttat attcctccca aagcaggctg aggttatcct gcacatactg ctgtatgtct 2720341 gaaatctcag ggttttggta gcaaagaata cccttctcaa aaatcagttc atgaagatcc 2720401 ttcgcataaa aattcgtgac aaatttgctg atgaatgtat gaaccgggtg gaacattctg 2720461 agccgcttct gatcattcac ctgctcatca taaagcgcaa tatagtcgcc ttcagaatga 2720521 tggttggact gattaataat gcggtagact ttctttctgc ccggtgtcgt cactttttca 2720581 ggattggacg aaattttgat cgtgtcgacc attttcccgt cttcttcaat ggcaacgagt 2720641 ttataaactg cgccgagagc cggctggtca taggcagtga tcagcttcgt accgacaccc 2720701 cagacatcaa tgcgcgctcc ctgagccttt aaattcataa tggtgtgctc atccaaatcg 2720761 cttgaagcaa tcaccttcgc atctgtaaat cctgcttcat caagcatttt ccgggctttt 2720821 tttgacaggt acgccaaatc gccgctgtcc agacggatgc caatgaaatt aatgcggtcg 2720881 ccgaattcct tggcaaccct aatcgcgttc ggcatgcctg aacgaagcgt gtcatacgtg 2720941 tcaactaaga agacgcaatc cttatgtgtt tccgcgtatt ttttgaaagc tgtatattca 2721001 tcgcggtaag cctgcacaag cgcatgcgca tgtgtgccgg aaaccgggat attaaagcgc 2721061 tttccggctc ttacattgct tgtcgcgcta aagccgccga ttaaggctgc tctcgctccc 2721121 cacatggccg catccatttc gtgcgcccgt cttgttccga attcaagcgc aacttcatca 2721181 ccgatgacgc ctttaatccg ggcagccttt gttgcgatta atgtttgata gttcacaatg 2721241 ttgagcaaag ctgtttcaat cagctgcgct tctaccaggg gtgcctccac cctcataatc 2721301 ggctcattgt taaaaacgag ttctccttct ttcatggagt aaagtgaacc tgtaaaagat 2721361 aagccgcgca aatattcaat aaaatcttca tgatacccga gttcatcctg taaataactc 2721421 aaatcgctat ccgtaaactt gaaattttcc aagtattcaa tggctttttc caagcccgca 2721481 aatacggcat agccattttc aaacggaagc cttctgaaaa acagctcaaa aatcgctttc 2721541 ttttcatgaa tgccgtctct ccagtacgtt tccgccatat tgatctgata aaggtctgta 2721601 tgtaatgaca ggctgtcatc tttaaatccg tactctaaca ctgtttttcc ccttccttac 2721661 tctgccactt gcgctccgat gctgtttgca aaatgggaaa gagcccatgc gtgcccctcc 2721721 tgattaaagc tggcaacagc ttgtttatgc acaacaatcc gaaaaccttt gttgtatgcg 2721781 tcaacagctg tatgcaacac acaaatatct gtgcagacac cggcaagatg cagttcgcca 2721841 atctgccgct ctctgagttt gagctctaaa tcagttcccg caaaagcaga atatctcgtt 2721901 ttttccatgt agtaaacatt aggttcatgt tcatgtttct gatatagagg caaaagcttt 2721961 ccgtacagat cttttccttc cgtgcctttt atattatgcg gaggaaaaag acgggtttca 2722021 gggtgatatt gatccccttc atcatgagaa tctactgcta atacgacgta atcaccgttt 2722081 gtgatgaatt ctttagttaa attgacgatc gcctcttcaa tcattctgcc gggctccccg 2722141 caggtcaatt ttccgtcact cgccacaaaa tcattcgtat aatcaataca aataagtgct 2722201 tttttcatag ccggcctccc cgccatcagt atgagaacat tatatcttat ctccagttgt 2722261 aagtgaattg ccatgaacaa aaagacaaac ggtccgtttg tctcttacga tttcagtact 2722321 gaccgattat aaatgtcgtc ctgaatatat atcaattcac gattcacagc gatatcagcc 2722381 gcaatgacga tgcctaaggg cgtatgaaac tggagatcag atacaatctt gaaaggcact 2722441 ccgtaccggc tcgccatttg gatataagaa gagtaagact gatactgaag ctctccatta 2722501 atcaaaaggg tgacgttatg gctgtttttc agctcgtgct ctgcctcttt atacggtttg 2722561 cttctaagca cctgtccttt cgtcagtgcc aaaacgactc tttctcttaa agagcctaaa 2722621 aacaaatggc gctcgtcagg ctttgtctcc aaaggcccat acattccttg ctgcaaatag 2722681 agatccattt tatcttcact caaaagcctg tcctcccgtc ttgtttgtct tcattatcac 2722741 ctgatcaggc aggagctaaa ctttcaagcg ccgtttacat ttctgttacc caatgaatga 2722801 tttttttggc cagctcacca gcaggggttt cctctgtatg ccggcgcaac gacgcttcca 2722861 gccgttcagg cagagttgct ttatcttctt cataggaaat gatcgtgctc cactccagct 2722921 gcggtaccgc tacaagcgtg cgcagttctt ttctgttttc atgcagatac acgtccgtga 2722981 tcattccggt ttgcgtattg atatttgctt ttctgatttt cataacatga cctctctatt 2723041 caaagactac ccatattata caataaaaaa gcaacagcct cttgtgaaaa ggctgttacc 2723101 cgttaaacga aactgtttca tcagtgatat cggcatcttt gaagagagtt ttactcgttt 2723161 ggttgttaat cttcacaaaa tcaccaagct gaaatgtgcc tgaccccgcc cctgaatgag 2723221 cgacgctttt gggcgaaatc gcaaatacgt ctccaaagct tgccgcggca ttatccgtaa 2723281 ctgacatgat ataaatcggc cccacaattg caggcatttc cccacctccg cattgattta 2723341 cagcatcata tgcaaggagc cgataatggt gcccgcctat tcagctggct ttgcgttttc 2723401 ctcgagtcgt gaccgctggc gcagcttgat caagcggaca atattcagga agaacgcctt 2723461 cactaccgca taaaccggca ccgctaaaat catgccgaga attccgccga agcttcccgc 2723521 tccgattaat agcaaaataa tcgtaagcgg atgggtattc agccgctttc cgatcacaag 2723581 aggagacagc aggtttccgt ccagctgctg aacgatgacg accacaataa tcgcaaacag 2723641 cgctttggcc ggcgagtcca taaaaccgac aatgacagcc ggcgcggcac cgagaaaagg 2723701 cccgacatag ggaatgatat tggtaatcgc catgacaatc ccaagaatca gggcatacgg 2723761 cagtccggca attaaatagc cgataaaaca cgctgttccg acaaaaagac agattaacag 2723821 ctgcccctgg aaatatgccg caagcgtatc ggataaatct ttaaaaatct ttaagccttc 2723881 tgtccgataa gaagccggta gaatttttac tgccaaatgc ggaaagcggt gtccgtcttt 2723941 cagcatgtaa aaaaggataa atggaacagt aataataaca agcgtgatgt ttgtcacgac 2724001 accaaacacc gcagataaac tggacgtgat attttgcggc aggttttgga gaaaacttgt 2724061 caatgactgt tcaatttttg atatcgatac ataatcctgg ttcatcatcc aggtaaacca 2724121 ttgagaatgg gacaaatcct ttgtcagcgc ctgaatctgt tttatataat caggaaggtt 2724181 gttaaacagc cctgtcacct gtgcggtgat gataggtccg actgacgctg aaataaaggc 2724241 aagcaaaccg ataaacagta aatagatcaa tagaatggat aatgtccgcg gaattttttt 2724301 ctcaagcagg cggacgaccg gattaaatat gaaatacaaa attcccgcaa ttagcatcgg 2724361 gaaaaacaat gtcgagataa aaacaataaa cggctgaaat acaaatgaaa cttttgttgc 2724421 tacaaaaata atcagcaaaa caaataaaat ctgcaatgtc caaaaatgga cttttgattt 2724481 caacaagctt tgttcctcct agtttttctt tgtctgtcag ataaaagaac ttatacccca 2724541 tcattgtaac aaaaatgaac tcatatcaga actcttaata taatgaaagg agtgttggtg 2724601 atgaaggccg tgacatacga tacagattca gaactggctt atatctatgt tcttcctccg 2724661 aaaaagaaca ggaatgtacg gactgaggag ctcagagtca atgattgtct cctgctggat 2724721 atcagccaag atggcaaaat cgccggattc gaatgttttg gtgaggcagc acacctctgt 2724781 gccccatttg ccgggaaatc ccggctgtat gtaaaagatt cagacggtta tcattttcgg 2724841 gtctgccagc atgcttcagt ccgttcctgc tatacggtgt accgtgtcac tttctgtttt 2724901 tcagatggtg actatcagga atttgccggc tttgaccttg atggaacaat gtatcatagt 2724961 gcgtttttac agcgcttaac tgaaaaatag gacgtcctgt tgtacgccta tttttcatgc 2725021 gcaagcactg ttagacccgc tcactgtaat ctggggtgac ggaaatcatg tgctggattc 2725081 tgatcaaaca aacagaattt cgggctcctt caattgtgat atggtcaggt tttacatcga 2725141 tcagtctgcc tctgaccgta tctcgtactg tctgtataac gaaccttgag ccgatgagct 2725201 ttttaatggt ctgatagaca taaggatcga ctaaagagac cagttgcgga ctaccttggt 2725261 tgaccatact tttatcccct ttgtgtgttt tatctcagct tatgccgcgc ttatggataa 2725321 tgacacaggc ttacctgata aaacaaaggg gtgcggagat tttaggagaa tacgtttgga 2725381 ggcgggtgta aaggaagtat cgatgaagcg gagacagcga agaaagctgg cgctgttccg 2725441 tacttataca ggctttatca cggatgcctg ggcttggtcg attaattggt ccagcttttc 2725501 tatttttttt cgtgcggttg aaggatcaat ttggcggtaa tgatggtggc cgcccggctc 2725561 ttcatccagt tcgtccgctt ttttgacaat ctgctgcagt gtgtttttat ctaattcgcc 2725621 ttcaggcaaa taggaatctg tatgaagcaa aatggctagt gcaatctctt ttgctgcttt 2725681 cggttcctcg ccaagccgaa tcagaagttt atgcgcccgt tccgcccctt taatggcatg 2725741 aatgtcattt cttttgtatt tctcataatc ccactttccg tctgtatacc attcataatg 2725801 gccaatgtca tgaagcagtg ccgcttttgc tgctaaatca ggattaatgt cagccttcac 2725861 agacagcctg tatgcatgat aagcgcaggc aatcgcatgt gccacgccgg aacgctgaag 2725921 atatttttgt gcaattggat gggtgaaaac atccattaat gtaacctttc tcatggaaac 2725981 ccctccttta gatattttta gaatcctaac ataatttgca gagaaactca attcttatgt 2726041 cacatcattt tgatcttctt atcatcattg ttatacccta aaagcaacgt ttcagtcagt 2726101 atatgcggct gttcaataaa atgcgctggc tgcagccttt tgtataaaaa aaagagcaga 2726161 aaatatctgc tctacaaaaa ctctttaata tcataaatgc ggccgttttc cgtccctttt 2726221 tctagtaaag aaagcagcgt gccggcaata aagtccggac tgcgaaggct tcctgtttca 2726281 tttaatttcc ggaatcgttc aatgtggtgg aaatcctttt tcgatgaaga acggatgacg 2726341 gcctgcatct cagtgtccat cactccaggt gagaacgaaa tcatgttcac cggcagctct 2726401 tcatcctcct gttcaaatcc gaatgtcctc gtaaacatgt cgagcccggc ttttgaactg 2726461 caatacgcgc tccatccctt atatggattt ttggcggctc ctgaagtaat gttgacaacc 2726521 gtctttttgc cgctgtatga agcaaaccgt tttgtaaaca gctgactcaa aagcacgggc 2726581 gcagtcaggt tcagctgata atggcgctga agctcgtcaa gagacgcttc gccggcacgt 2726641 ttgatcggcg ttaccattcc ggcgttatta ataagggtaa taccagaata acgatctgaa 2726701 tcgatggatg agagcaatgt ttcaaattgc tgttcagctt cttcgagatt gatgaggtct 2726761 atttgatgct gcgttagttt tttgtgagag acatctgttt tcgttctgga taaggcatgg 2726821 acttcatgcc ccttttctaa agcctgtaat gcaatggctt gacccagccc ttttgacgct 2726881 ccggtgatga tataaagttc cattggaaac ctccttttcc gttattattg tacggcacct 2726941 cttttacaca acacaagcac gcggcctacg ccttcttgtt ttcctgcgct gtgacttttg 2727001 ggatgaggaa cacgatgcct gcaattccga gcaggatcag tacgacatag atcatcggca 2727061 gcagcaatga tgatgtttct tgttcatctt ctgtttccgt tgatgatgtc tttgtcattg 2727121 gtttttcagc aaaagtaatt ccaagctgtt tcgactgggc cgcaatcgtg ttggaatcct 2727181 cggcatttgt tgatgtaaac aaatctttta tcagctcggc gtccttgtcc ttcggtttat 2727241 caaaagtgat atccttttgt tcctcaggca gttctgtttt ttcttcatag taggtatctt 2727301 catgcaaata attcgtatcg atttcgatgt cttttttctc atactggttt ggcgcgacat 2727361 ctgtattttc ttcagtttgg gcagccgctg cagagggtat gaaaagggaa aaggagagca 2727421 tacaaatcat gatccccttt tccatgctgc gatcacgctt catacgtttc atcgctttct 2727481 gctgtgtgtt cagccatcaa ccggataatc agcggcagag ccacggcaat caccgtaatg 2727541 atcagcagaa ctgttattcc cattgtaaac aagtgcccag taccgtactg gatgtcgata 2727601 tatactttcg aaaccggatc ttcaaatgta aagttcggca tgatcaaatc aataagcggt 2727661 gcgacataga ataggatcat tgctgctgaa gcaacccagc cagggattga tccgaatctg 2727721 aatgccgtcc ggatgaaggc agagcttgcg accagcaata gaatcgtaaa caccgaccac 2727781 ttaatcgtct gatcgtccgg cagtgaataa atattcaagc cgaacaagct gatcataagt 2727841 ccgacaagga tattcagaat tccgaataac gctcctttga cgagaagcgg tgcgttttgg 2727901 taatacgagc tgaaatagcc gattaacaga ctgctgatca acacaatgac aaggatgaca 2727961 accggaggta ccgtctgaat tttttcttcc ggaacctctc cgctgatttt aagcggattc 2728021 gctaagtaat catatacata gccattgttt tgcccgtcta ctaatgtatt tccgagtatg 2728081 ccgtatacgt catttcgcac gagtttcgtg gaggcgacat ttttccccca gttgttgttt 2728141 aaggtgtcgg ctttcgcttg aacatcatta acgctttgct gcatgttggt tgtgtaatca 2728201 atgatgccgg actggcgatc agacaatgaa cccatcatgt ctgacatttg cagcacttcc 2728261 tggccgaccg tatcttggac actcagtgcc atggtaccag acagcccatc gttgctgaac 2728321 gtcgcagatt cctgtgttgc gcccgttaca agctgttctg acgcttttgc ggcactttca 2728381 gagattttcg tcagttcgtc gagaacacct gcttgagagt cacggatata gccgctgtag 2728441 tcgtccgcaa atttggtcat gccgtcgatg aagctgttaa tatcctcatc tgtttgcatc 2728501 gtgttgtttt tgagagcttc ccagctggct gattcttcag gtgtgagagc caggactgat 2728561 tggacgttgc catcttgctc ttggatgact tcacctttaa taatagtcaa agagcctaga 2728621 tccagattat catttagcgt agacttatat aaatttaaag agttgtaata cttcatcaag 2728681 ttagaaatat tatcagtttc aattctactt gaaaaaattg aacttagttt ttctttctga 2728741 tctatatagc ctctactctg caaagtttgt attatttcgt cttccaaatt gtatattaac 2728801 ctataagcat cattgacatt attatcaaaa tcaaccaact tttttgttaa gtcaccaatt 2728861 tgatcattta attttgaaac tgttttattt aactctttaa tttcttgatt taactcatca 2728921 atatgtttct ctagtttgtt gttatgttcc tcttgttttt cttgaagtgc attttctatt 2728981 tcctctaatt ttatcgctgc ttcgttcaga cgtttttttg cacctgaaat atcagtttca 2729041 ccgtcagctc cgtcaccctg tagcccatca ctttgatttg agccatcgtt ttcatctgcg 2729101 agttcaatca aagagaaatc tgttttagag gttcctgtat tctccgtgtt tgtatcttgt 2729161 tcaggaacgt tttttgaaga ttcttgatgt ttttgtcccg tttcaatgtt agtttgaaca 2729221 tcattttgtg atccattatc ttgagtaccc tcttctgatg agccagtatc ttcatttgtt 2729281 ggctgatcat cggatgttgg aatatcattc gacggttctt cagtattagg agaatcatcg 2729341 gttgatggtt cttcagcatc gggtgttgtt ggtttttctt gttcaggttc ttttaaccct 2729401 tcagagatat ctttaatttc agttgcaaca tttttgagct catcccgctg cttctctaaa 2729461 tccaatttta tatcttcaat atcttcctta tctgtgtcat ctttattatc agatgtgtct 2729521 tctccatctt ccttttcgtc gctttcctta ggtttaagta aactaaggcg gttcttcccg 2729581 atattctctt gcaattgatt taaattttga tatttaatag cttcatattg acttttatat 2729641 cgagatagaa atgcattaaa catgtcattc tcaatttttt tcatacccat ttcttgcaat 2729701 ggcacttgat tttgccttaa cttttcagca ttgttcaacg caaggtttgt cagtcctatt 2729761 tgtgtcttcg cttggccgat cccggttgcc aatccgctca tgcgttcgct gaactgattc 2729821 gccttttgct gtgcctggat ggcatccaga cctgtccgga tttgctgctg tgttgaatcc 2729881 tgggctgcca aaagcagctt tttctgattc tcttgatatt ctttgtacct ttcaactgta 2729941 tcaatgaatt ctttcagcgt gtttttggct tcctccgccg tagaagcttt ttcttttgtc 2730001 gtgccttgcg cttcattcat tgatttcttc agctcatcga ttaagtcttt ttgctgtttg 2730061 atttcacctg ctaaatcatt agagcttggt ttgtaaaagt tgtacatgac attctggaat 2730121 tcagattctt tattgacgat cttgtcaaat tctcctctga tgttgtccac tttttgcgaa 2730181 acaaaattcc agtataaggc cgacattttt ttgttcattg tcttttgggc atcctcaagc 2730241 tcacgctgaa ctttttcttt gttaaccgca ttcaggttat cttgaatgct gaattcgagc 2730301 gttgcctttt gaggatggtc tttgtcatag ctcaaaatgt tttttgagaa gtctgaggga 2730361 atgtagacaa tcgcatcgta tttctttgaa gcgagaccgg tctcggccgc gcttcggttt 2730421 acgaccgtcc acgaataatc aggacgttca cccagaacgg ccgctacttc cttgccgaac 2730481 tgggcggatt tgtcctcttc atcagacttt acctcatcac tcaatacgcc tgtgtcttca 2730541 ttcaccaccg cgatttgccg ggtagaattg actgcttttt tcgttgggtc gtctccgata 2730601 aatcggaaaa acaacaccgg cagcagcaaa atgatgatga cggcggatat taacttgatc 2730661 aagctttttc gttgttctgt catctagcac tctccctttc agcagaacat aaaggaattt 2730721 gaactttttg ctccttcccg ttttccacaa catatccgaa gcccggctga atctcaggct 2730781 cctgtctttg gtacgggaga ggaatgacat tttgctcaga ctttttcatc agcagaatcg 2730841 cgtggcggat ttgcttcatc tcagtcgtca aggagtcata gccttttgag aattcgctgt 2730901 ggtttccgcc cgggataaag ctgaacccaa gatgagcgta tgatttcatg aagttagcga 2730961 gacgatcttg tattctcgta tcaatcgtct gctggaatct cgttatcccg tcaatcatca 2731021 gcacgacttg tgagaatcgc agattttgtg cgtctccttg gcggacggct tctacataca 2731081 tggcttctct tgttttgaaa atgtcttctg ctgtttcaat ccactgctca atatcttctt 2731141 tcgtttccaa atatgaaaca tctgattcct tcgcataatg agataagccg cggtcaatcg 2731201 agtcaaacag gccgatcatt tcggtttcat catcaatcag atgttcaagc atgactttta 2731261 ggacgtttgt tttcccgcgc tgagtttggc ctaaaatcag gcagtgctta tgcttgccca 2731321 aatcaaaata gactgggctg actgtttctt catgaagccc gatcggtaca gataaaggct 2731381 tgcgttccag cttgaagcgg atagacaatt ctctcgtcga caagctctca ggcagcatcg 2731441 gaatcggtgc cggctgctcc attgaagcaa atcgcccttg aagtttctgt acgtctgatt 2731501 tcagctcgtt gaacatgccg atatcatcat cggcgtcaac aggcaggaac atttgcgcga 2731561 aataaagctc ttccttttga atgatgacgc gtcccggaat cggctcaaga ttgaatttcg 2731621 gacggccgta aatggaatat ccttctgatt gatccatgag ataatggaca atctttgttt 2731681 tcaagttatt taacaatgac tggcggacag cattcacccg cgttgctgtc agcataaagt 2731741 agatacccaa gctttgtccg tctctggaaa gctggacaaa ttccgattca agctcatgca 2731801 tctcatcctt gacaatgtca aagttgtcaa tggtgataaa aatgaatgga agctcttctt 2731861 cgctcagcgc attgtacatt ttgatgtggc tgatttcttt ttcccggaac aaacgtttac 2731921 ggcggtcaat ttcttctttg atgcgaatca tgaacttttc aattttcctt gactggtcca 2731981 tcaggaagta atccgcggta tgcgggagct tcgctaatgg cagcagcgtt ccgtttccga 2732041 aatcaaagat atagacatga agctcttcag gtgtgtatac gtccgcaaaa ctcatcagga 2732101 acgttgcggc tgcaatcgat tttccgtagc ccgaagagcc gaagatgccg atatttccat 2732161 cttccatcat cttataagca attggcgcct gtctttgcag atcaggttca tcgacatacg 2732221 caaagtggaa atggtctttt tcgtttgaag ggaaaagagt gcgcggaata cgttccgcaa 2732281 gcggcggcag ccaagggctt ggcagcttct cgattcccat ttcatcttgg atgcgttcaa 2732341 tttcgtcaac tacagcttcg atttcggttt gaacgtcttt tttcgcgtta tcttcggtat 2732401 caacctcaga aagcgggatc agacccgtat ctgtgacgat cgcgatttca tcctcggtac 2732461 cgtagacttc ctctaagtaa ggcgccccgc tccatgcaga ttggaacagc tcatacactt 2732521 cattgtttcc gacctgcaaa tagccgcggc ctgttacggt aatgtttgcg gcatcgctgt 2732581 ttttcaaaat ttctttactg tcggtggcat cctggacctt gagcgctact ttaaagcgcg 2732641 agttactcca gatctggtcg tcgatgatgc cgcctggctt ctgtgtcgcc aaaatcaaat 2732701 gaacgccgag gcttcgtccg atacgcgcgg cactgacaag ctccctgata aaatcaggct 2732761 cctcgctttt cagctcggca aactcatcag aaattaagaa caagtgaggc atcgccactt 2732821 ctgctttccc ttgcttgtat agctttgtat agtcattgat gtgattgact tgatactggt 2732881 caaacaggcg ctgccttttt tttagctcgc ttttaatgga agcaagcgca cgcatactga 2732941 agtttttgct tccttcaata tttgtgatcg tgccgaggag gtggggaatg ttacggaacg 2733001 gctgcgccat tcctccgcct ttatagtcaa ttagtaagaa agccgcttca tgcggatgaa 2733061 aatgcactgc aagtgacaag atgtaggtct ggagaaattc acttttccct gatcccgttg 2733121 tccccgcaag caagccgtgc ggaccgtgtg ctttttcgtg aaggttcaga tacacaatgt 2733181 catctttccc tttatagccg atcggcactg acagcgactt cgacgattca cttgtcagcc 2733241 atctttgctg aatgccgatt tcttttactt ccttcgcatg aaaaagctcc aggaacgata 2733301 ccgtttccgg aatggaattc gtaatgccga cctggtggtt cagcgtccgc agtgtgcgtg 2733361 aaaaccgttc gttatcctca cgctgatgat gatcgagacg gaacggaatt cttaccgctt 2733421 ttttcttttg tattaaaatg tcgccttcat gctcattaat gtagcggaca agagttgtaa 2733481 tgttttccga caagctttcc tttgtttctg cagcgacaat tgtcgagatg cccagatgct 2733541 catgctgccc ttctaaatat tcgagaatga catgctcaga gatcagctgc tgattcgtga 2733601 tgacaaatac aaaatgcggt ttgaactgca gtttttcttt gtcatcttcg agatcacgct 2733661 ctctgatcaa ttcgtaaagt gaagacagga gctgatctcg ggtttgctca ttataaataa 2733721 atccttttgc ataaatatgg ggcatttgaa attgcggaag ccacttcatc cactcccagt 2733781 ctttatactc ttcttcatga aaaataaata cgaaacgcaa atcgtgatag ctgttaaaga 2733841 acgacagctg tccgattagc tggtgaatct catttttcac aatttgtgat ttaccgacaa 2733901 gccccatcgg accttctgcc aaatcgaccg tcaccggcgc attacggata tctttataga 2733961 cgcgttgcat gtgctgcgat ttctccatga ggtcatcgat atcacgattc gccaagtctc 2734021 cgccactcat attgatttca tagcttgacg gaactgttcc cgtcccaagc cgcagctgga 2734081 gataatcctt gctttcaagt gatttttccc agatccggtc actgatttca cttgttaagt 2734141 atttcatttg ttcaaatgaa ggaaagtgaa attcaagaac ctgcttttgc ttttcagcaa 2734201 gtgcctgaag ctctttccgc ttattgtcta agtaaagctt atatacacgc tcccgttttt 2734261 cctcgcgttt tttccgctgg tttttatcac ggaaatattg cactgtcgag gtaatgagag 2734321 tcatcataaa catcgccaaa gaaacgagta taaatatgcc gcgcggctgg atgatggcaa 2734381 ctacgcccat cacgatcagc atcacaagcg gaggcaggat gacgagccac agccctctgt 2734441 tggtttgatc gctctcctga gagggaaaac tgaaagaaac gcggtcatcc ggcagatcgt 2734501 ataccatccg cggcgttctt ctgtactgcg gatatttttt ctgcatctct gtactcggtt 2734561 tgaccgtttc tgttaacgct gtttcaaact gggcataatg aacaatttct aaaaggtctt 2734621 gttccgtcac cctcatttgc gtgaagttcc agaatatttc atcccccggc ttgagcggcg 2734681 tattggcgtt gattttctct ccgttcaaga agatcgttcc gctttcaggg cggaccgacc 2734741 agctgccgcc tgcacggagc aaagaaaacg tgctttgttc tgcaaatgca aaatcttgcg 2734801 gattcagata aatatctgca ttcgtttttt ctgaggaaca tacaatttca tcccgatttc 2734861 ccgtaaaata aacggatttc tcaggttcac tgcccgtcaa tatcaagcgt atatcctgct 2734921 gatccgtttg gagagtaaat gatatatccg tctcaatcgt gccgagacaa tcatttccca 2734981 ggaaaacttc gtattggccg ccggattcct ttcttttaag agaaatcact ccgctattaa 2735041 atggaatggt gctgatcgta acagaatcct tcacatcagg ccctatggtc accggatgag 2735101 acgacgggag gttagacaga tttaattttt gaacgttatt ttggtaaaaa acccataata 2735161 gactcaaatg gcgaaccccc ttacggccga atggcagcat gcgatgacct gcgcttcatg 2735221 tctcacgtta tttgtcatct tttttctcat ctttcttttc tgtttctttt ttctcgtctt 2735281 ctttttcctt ctgttcttct tttttcgctt tttcctcggc tgcggctttt tcttctgccg 2735341 ctttctcttc tgcttgtttt tcttcgtctg tttgtgtctg ttcttcgctt gtatcgacta 2735401 acgatgtttc agaattagac tgtttatttt cttgacgttc tttttgggct ttttcaagct 2735461 cactatttac tgaatcaagt tctttttgta tgtcttcatc atttgtatcc tcagataaaa 2735521 gctgctgttt atatttagct agggcaaagt aaatataatc attgtattcc agcttacggc 2735581 cgatactgat cgcttctttg tattctcctc gaccataatc aatccaatat aagaaatgct 2735641 gagggtctga ttgaagggtg actaaattat tttctatatt tttggttttt gcactcccca 2735701 ggttttcgac ctcaacatag gacgtcgcca gctgatactg caccgattca ggcaggcttt 2735761 ccgcatcgta cttggacagt gtgctgatga cttcactgta ctgcttgttt aagaacgcac 2735821 ggttgctgtc cactatcgcc tggtgctttg gctgcgcgaa aaataaggcg tacatcgaat 2735881 aaataagtgc cggtacaagc aaaacaatga gccccaggcc gatatatcgc tggatgttcc 2735941 acttctttct cgggatatgt atgtatgttt ttgctttggc ttcgagctca tcaatatggg 2736001 tttgaatcag ctcgagcaaa tcatcatagg attcagcatc taatatcgcc tttgcctctg 2736061 cggagaacgt cagcgtttca ttgaatttca ggtagtcttc aaacgcaaaa gcgccgtcaa 2736121 ctgccaaagc cgctgccgct ttcagctcct gccatactct ttcctcatca cgctcgtaag 2736181 gaggaatgct ttcttttact ccataatgga gaaaataagg cgtaagccct ttatcgaata 2736241 caatgttttc aggagcgaca atcaaattca gcctcgacag attgtgctgc tgtacggctt 2736301 gaacaagctg ataggcaaac tgccatttac tttttttatc cttagctttc atgaagcgga 2736361 atgctttata ggaggaggga ggttggattg tgatgattac ttcatcatcc gtcacatcga 2736421 tttctttatg aaaaaatgga tttatatctt tgatcacgtt agcttcaaga ccgtcgagaa 2736481 gctttatttt ttcccgttga aaggtaaatg tatagccggc atctgttttc tcggcaacag 2736541 cttctaattg gttttctaaa tatgattttt gttcacctga cattcaacca gatcctttca 2736601 taatatttca agccggtctc cgtttgtaat gccgcaatca gacagcttgc attctccgga 2736661 aaacacctta tccttgttca ccactctgat ccagtgccct tcgcgcggag gcatagatac 2736721 gctttgggcc tgccaagcaa tatcaattac ttttttcacc gggtggtaat ctgacaatct 2736781 gagatcaaag acactgccgt tataatgttt caaatctatt gtaatatcaa tatacattta 2736841 ggatcaccct tacatagaaa gagcgccgtc ttcttttgaa tcaggcgctc cttccctttc 2736901 atactgttat ccgcggattt gatttgcgat gtcttggtca gtagactcaa gtgtatttgc 2736961 tgtttgatca agctgctgat tcacatcttg aagcaaatct gacattttga taaatgaagg 2737021 tttgagctgc tcgtattgat ctgcgaacgc ttcgcttgaa gcaccttccc acatgctttt 2737081 caaatcagag atcattcggt ttaaacgatc aacctgattt aatacttctt ggctttcaac 2737141 gccgtattgc ttcgccatcg ctcttagctc ttcgggtgtg acacgaatta atcctgccat 2737201 attcctcatt acctcctgtg ccatcagcct aaatatgggc taattcactt atttttagaa 2737261 cgtcattatt ataaaaacag tttttcggca tagtcaaaca aatatgtttt aattttacaa 2737321 aatgagtcca atggtttacc ccgaatcact caaaaatgac atatactgta aagtaaatag 2737381 gtttattttc ttaatcttct cttcattctc cgaataatcc aaaagaccca aataactctc 2737441 caactcccaa aaaaaacctt tcagaaaatt tgatgctaca gcaccatttc tgaaaggttc 2737501 agttttttct ttccttaatt agtcttgcct ccgatgactt tcttagaaga ttaataggat 2737561 aagctgtcgt attatatgag acatacactg tcctgcaaaa aggcgattac accgccaaat 2737621 gtatatagaa cgtttctctc atgaaattgt ttttttgctt ctgttctttg ttgttgattt 2737681 tcacaaacaa caacaatcat aataaaagga aggggatgag atgtcaaaga gaaatcaagc 2737741 acgaaaagta gggagattta tgaccatgcc gaatgatccg tttaaatata gttttgacag 2737801 acttgaagat gtggctgatc atatcagcga cgttctgcgg tgcccgatca ccatagagga 2737861 tgttaaccac aagctgcttg cctacagtac acacagcgac tgcacagacc ctgcccggac 2737921 gtctaccatt attggcagaa gggtaccgga gaaggtgatt aacaagctgt ggaaagacgg 2737981 gacaattcct gctctcttaa aaacggacca gccgatcaga gtcaagcaaa tcgatgaagt 2738041 cgggctgagc aatcgcgtcg ctatttcgat ttggaaaaac aagcaagtac ttggcttcat 2738101 atgggcgctt gagatccaaa aaacattgtc cgatgaagat ctgctgacat tgcaaatggc 2738161 agcaaaagca gtgaaaaaca agcttctcaa acttcaaatc agaaaaacga aaaatgaaga 2738221 acgcagccaa gaatttttct ggaaaatgct gaccggacac atccatcagg aggatgatat 2738281 ggcggatggg ttccataagc ttggaatggc cgctccttca gagttttccg ttatgatcat 2738341 ccgcataaat ggcgagctga ctgaaaaaat cgaacagcag ctgcaatatt tacaggaaac 2738401 gacccagcag gtttacgtgc tgctggcgac cgtagattcc aatgaactta ttatattaac 2738461 ctcacccaaa acagatcatc cttttcaaga tttaaaacag tttgctttaa gtacgcaaaa 2738521 acagctgaag gagcggtata aaatagaaga cgtttctatc gcttttggcg gaatatacaa 2738581 ctctatttct tttgtctccc gctcctatca ggaagcattg tccgtcttaa aaacgaagga 2738641 acggttcgct gaagagacca aacatctttt cagcttttct gagttaggca tttatcaata 2738701 cttagatgtc ttaaatgaaa aacggaaaca ggcgggccat tataattact cgctttccaa 2738761 actggaacaa tatgaccggg atcaccagtc aaatatggta gagacgctag agcgctttat 2738821 tgaagcggac agcaacgtga ataccgcttc caagctgtta aatatacacg ttaatacgtt 2738881 gaattaccga ctcaagcgga tcagccagat cgctgaaatt gatttgaaaa atgtgaatca 2738941 aaaattcacc atctatttag atatcaaact tcggcacatg gatttgtgaa atttcacaaa 2739001 tccatgtttt tttattttct taatcaaaca aagaattttc caaaatatca agctacacta 2739061 aaaatatcac atatacagga ggagacagat atgatcatag gggttcctaa agagataaaa 2739121 aacaatgaaa accgtgtcgc attaacaccc gggggcgttt ctcagctcat ttcaaacggc 2739181 caccgggtgc tggttgaaac aggcgcgggc cttggaagcg gatttgaaaa tgaagcctat 2739241 gagtcagcag gagcggaaat cattgctgat ccgaagcagg tctgggacgc cgaaatggtc 2739301 atgaaagtaa aagaaccgct gccggaagaa tatgtttatt ttcgcaaagg acttgtgctg 2739361 tttacgtacc ttcatttagc agctgagcct gagcttgcac aggccttgaa ggataaagga 2739421 gtaactgcca tcgcatatga aacggtcagt gaaggccgga cattgcctct tctgacgcca 2739481 atgtcagagg ttgcgggcag aatggcagcg caaatcggcg ctcaattctt agaaaagcct 2739541 aaaggcggaa aaggcattct gcttgccggg gtgcctggcg tttcccgcgg aaaagtaaca 2739601 attatcggag gaggcgttgt cgggacaaac gcggcgaaaa tggctgtcgg cctcggtgca 2739661 gatgtgacga tcattgactt aaacgcagac cgcttgcgcc agcttgatga catcttcggc 2739721 catcagatta aaacgttaat ttctaatccg gtcaatattg ctgatgctgt ggcggaagcg 2739781 gatctcctca tttgcgcggt attaattccg ggtgctaaag ctccgactct tgtcactgag 2739841 gaaatggtaa aacaaatgaa acccggttca gttattgttg atgtagcgat cgaccaaggc 2739901 ggcatcgtcg aaactgtcga ccatatcaca acacatgatc agccaacata tgaaaaacac 2739961 ggggttgtgc attatgctgt agcgaacatg ccaggcgcag tccctcgtac atcaacaatc 2740021 gccctgacta acgttactgt tccatacgcg ctgcaaatcg cgaacaaagg ggcagtaaaa 2740081 gcgctcgcag acaatacggc actgagagcg ggtttaaaca ccgcaaacgg acacgtgacc 2740141 tatgaagctg tagcaagaga tctaggctat gagtatgttc ctgccgagaa agctttacag 2740201 gatgaatcat ctgtggcggg tgcttaattc acaataagct tgcagaaaga tttctgcagg 2740261 cttttttatt ttttaaaagg aaaaaagaga ccatttcacg aattatgact atgaagttga 2740321 tcataaagga ggattcatat ggctgttcag caatatggcg tgttaaaagg catagtatta 2740381 gacatgaagc gggaaacaga tgatgacagt cctcatttcc aagtcaaaat gctcggtgaa 2740441 gagaatacgt attacaggtg cgccatcaat gtgatgtcca gttctgagga atctgaagta 2740501 ttgtatttgg ctgacgatca gtttgattcg ggctcaatta ccatccttcc gaacatgccg 2740561 tatggatata caaggatcaa tgaagcaaac cgtgaagtgg cactggatta tgtgcggggc 2740621 aatttgtttg acccgcggga aatgaagcct ttgcctcatg aaatcacggg acctgataat 2740681 gatttaaatg attttattga aacctatatg aagaaagcac aagatgagaa aacgccggtt 2740741 tatatattcg gttcaaaatt cggccctgaa caggctgcag ataaaatatt cggctttacc 2740801 ccgactaacg gaatgcacaa tatccatatg aatcaaggga atgcaatgga tacccgctgg 2740861 aaaaaagaca acggctcttg gcatgacggg ggtattctga ttcagtttgc agatcagtgg 2740921 gccgctgtgt ttttagcgtt tttatcccaa tcttggtgta ccgatgaaaa cggaaaccct 2740981 gtcagagatt gtgatcatac ccaaacgtct gcgtaagata gaaaaagaga ctgcggcaag 2741041 cagtctcttt ttgataagat tacacatttt caacagtctt taggctgttt ggcctcatat 2741101 cgctccaatg cgattggata tagtccaaac aagcttcacg ccctttttgc tcatgaacga 2741161 ctgtccagcc gctcggcaca tctataaaac ccggccatag ggaatattgg ccttcttcat 2741221 tgaccagcac caaatatgtg ccatccgcat tttcaaaagg atttgccatt ctatttctcc 2741281 tcccttattt attcaactct tccaatttga cagcgagaac cttgccgatt tgagccagag 2741341 gttcaggctg acataaatct ttatgacggc agtcgatgtc gatttgttca atctgtccgt 2741401 taatataagg cttccacgag tcaggttcaa tcgggtcaaa ccattcagga atgattgttg 2741461 atctgaaaaa caaaacattt ccgcggaagg ttttcggctt ataggaacct aaaatgccga 2741521 cagaatttac atacgtattc ttcaaattta aaatgaccgt ttcatccagg ctcgcaagcg 2741581 cactgccgtc acggcgaaga atctcaatcg ccgcttcaaa atctagcggt ttttccccta 2741641 agctgtctgg atcatacccg cctaacgcca gaagggcaat aagcgcttcc tcatcatccg 2741701 gtgcctcttt tataggaagg aagtggttcg gataggcgtc cagcatcacc aacagggata 2741761 cttcttctcc ttgattttgc agctgggtag ccatcgcttg aacgacattc ccgcccaggg 2741821 accagcccag cagatggtac gggccttttg gctggaccgt tcggatttgt ttaatgtaat 2741881 cggcagccat gtcatcaagt gttttcggaa gctcctcgcg ctgcccgatt ccccgtgcct 2741941 gcaagccgta gatcggataa tctgttccta tattggtcat caaaccggca taacaccagc 2742001 tgagcccccc tgccggatga acacagaata aaggaggctt gtctccgctt gttcggagcg 2742061 gcagcagaac gtcaagagcg ctttggcttg atcccatttc aagtctttca gcgagcccgg 2742121 ctacagtagg tgcttcgaac aagttgccga tgctgagttc aacgccgagc gcttcacgaa 2742181 tgcggctcat gagctgtaca gcaagcaagg aatgtccgcc taaatcaaag aaacggtcat 2742241 caatgccgac acgcggcaag tgaagcacct ccataaagag gtcacagaga atttcttcct 2742301 gcggcgttct cggtcctcgt cctgtcactg ccgctgcgaa atccggagcg ggcagcgctt 2742361 tacgatcaag ctttccattc ggtgtcagcg gcaattcttt catcgtcaca aaggcagcag 2742421 gcaccatgta atccggcagt ctctcagcag catatctgcg cagttccgcc gtatcaaatg 2742481 tttcttccga agggatgaca taagctgcta accgtttatc tcccggctga tcctcacgaa 2742541 cgatcactgc cgcatcttca agctgcggat gctgaacaag cgcggcttca atttctccca 2742601 attcaatccg gaatccccga attttcactt gatggtctgc acggccgaca tagtcgagag 2742661 aaccgtcagc gcggaggcgg gccacatccc cagtgcggta catccgggtg cctggaggac 2742721 cgaacggatc agctatgaag cgttcagatg ttaaaccagg ccggcctaga taacctcgtg 2742781 ctaaccccgc tcctgataca tacagctctc cggcaacacc cggcgggacc ggctgcaggc 2742841 gttcatccag cacgtataca ccaagatcgg gaatgccgca gccgatcaag ctgtttgccc 2742901 gtaaagctgc catgcttcgg tctaattcga tatagctcac atgcaccgtc gtttctgtaa 2742961 taccatacat attgataagc tgcggtctat tttcagggtg gcggttgtac caatcctcta 2743021 aacggctgag ttcaagcgct tctccgccaa aaatgacata gcgcagactg agtgcctgtc 2743081 cgagatccgg ctgttcccgt tccgcctgca taaactgata gaaagcagac ggtgtctggt 2743141 tcagaacagt caccccctct ttgacaagca ggcgcagaaa cgcttctggc gatctgctga 2743201 cgtggtgagg cacgattaca agacgtccgc catgcagcag aggaccccag atctcccaca 2743261 ccgaaaaatc aaacgcatag gaatggaaca tggtccagat atcacctgag ctgaaacgga 2743321 accagtgctc ggtcgctgca aataaacgtg ttacattttg gtgaggaatc atcacacctt 2743381 ttggaacacc tgttgagccg gatgtataaa tgacatatgc cgtattcaaa ggggaaagcg 2743441 gctgagtcct atccttattt tttggattac ctgcagggta cgtgtttagt ttctctgcca 2743501 gctcgggatc atccagcacg attttcggca cgttttcaac tggcggaatg tgatttgcag 2743561 ctttagtgtt cgtcatgata aacgcaggct gtgcatcttt tagcataaaa gcaattcgat 2743621 cagccggata atccggatca agagggagat aagctgcccc ggcctttagc accgccaata 2743681 ggccgacagc catttccaac gatcggggca gtgccaatgc cacaaattgc tccggcccga 2743741 caccttcact aatcatcatt cgggcaagcc ggtttgctct ttcattcagc tctgcatagc 2743801 tcagttcctg attttcatat acaacggcaa tggcatcagg acgtaaagca gcctgcttct 2743861 caaattgctc tggcaaacat gcgtgcggaa tcttttcaga tacactttgc caatcagtca 2743921 ccatgctgct gtgttcctct ggcgcaagaa tatccagatt tccgatttgc tcgtcaggat 2743981 cagactcggc agcctccaac aggcgcatca atcggtcagc aagagcctga gcagtttccc 2744041 gtttgaaaag atcagtgctg tattcaagca gtccttccat tccgtttggt gtcccgtcag 2744101 caaggcgatc ttcactaatt tccagcgtca aatcaaactt ggcagaaccg acactgttga 2744161 ttcgcaggct gctctccata tcaggaagat gcagttcagc gtccggtgtg ttttggaacg 2744221 caagcatgat ttggaataaa ggatgcgtcg cacgcgaacg agccggattg agcacctcta 2744281 caagtctctc aaacggcaga tcctgattgt cataggcggc cagattcact tcccgtactc 2744341 tgtctagaag ctcacgaaag cttgggtcac cggacgtatc agttctgagc accaatgtat 2744401 taatgaacag ccctacaaga tcgcccagcg catcatcatt ccgtcccgcg atcggactgc 2744461 cgatcggaat gtcggtgccc gccccgagcc ttgtcaataa agcggcgaga ccggattgaa 2744521 gcaccataaa caggctcacc ctatttgcgc gagccagctc ctgcaatcgc ttgtgaaact 2744581 cgggctcaat acgaaaatga atcgtatctc catcatgact cggctcagcc ggacgtgaat 2744641 aatcggttgg cagttcaagc tgatcaggca ggtttttcaa ggtttctttc cagaaagcaa 2744701 gctgtccggc aatcaagcta tttggatcat cctcgtttcc aagcagttct tgctgccaaa 2744761 gcgcatagtc tgcatactgc acagcaagag gcgcccattc gggagatcgt ccgtggcagc 2744821 gagccgcata agctgtccca aggtctctgg tcagcggtgt taaggaccag ccgtccccga 2744881 caatatgatg gacgagaaga agcagcacgt actcgtcagg accgatcaca aaaagctcgg 2744941 cacgaaaagc aggttcagct gcaagatcaa agctgtagcg tacagcttcg gcaagccgat 2745001 cagaaagctc cttctcagca atttcagtaa catgtaactc gggacaggct cgatcggcat 2745061 ctaaaatatg ctgataggat gtcccctgtg attcagggaa gatcgtccga agactttcat 2745121 gacggcagac gaggtcataa agtgccgctt tcagcaatcc ttgatccaac tcacctgaca 2745181 aacggacagc aaccggaata ttataagtag gactcggtcc ttccagacaa tgcaggaacc 2745241 atagccggcg ctgggcaaat gagagcggga tcttttcagg ccgctcagct ctctgcaaag 2745301 cgggacatgc actctgcgcc aaatcaagat gggcagcgag tccggctact gtcggttcgt 2745361 caaagagctt ggcgatacca agttcggctc ccattacctc gcgaatgcgg ctcatcagac 2745421 gggctgcaag aagagaatgg cccccaagct cgaagaaact gtcatcgata ccgacgcgtg 2745481 ccaaaccgag aacctctgca aacaagtcac acaatatctc ttcctgagga gtccgcgggg 2745541 cccgatcact gacagatgtg ctgaagtctg gtgccggcag tgctttccgg tcaagcttgc 2745601 cattaggtgt taacggcagc tcgtccatct ccacaaacgc cgacggtacc atataatcag 2745661 gaagactagc ccccatataa cgacgaagct ctgcagtatc aatagcagca tcagcgacta 2745721 cataagccgc caatcgtttg tctcccggct gatcttcccg tacgacaacc gcggcctgtt 2745781 caatgtgcgg gtgattggca agcacggcat caatttctcc aagttcaatt cggaatccgc 2745841 gaattttgat ttgatgatcc gcccgcccga tataatccaa agacccatcg gcgcgccagc 2745901 gggcctggtc tccggtccga tacatccgag ttcccggcgg tccgtatgga tctgcaacga 2745961 agcgctccgc cgttaaatca ggacgatgga aataacctct ggccaagccg gttcctgcaa 2746021 tataaagctc tccgacaacg cccggcggca ccggctgcaa tccattatca agcacataca 2746081 cctgcgtgtt ccaaatcggt ttcccaatcg gaggaacgcc cttcagccct tcttcaagaa 2746141 aagctgcggc agaccaaatc gttgtttcag tgggaccgta taagttcgtg actgaacaat 2746201 gaaggtcttg aagttcctgc aaaagaccgc tcggcagcgc ctcgcctcct acaagcactc 2746261 taagcccccg aagtttctca ggttcactcg ttaccaaagc gtgccacagt gtcggtgtcg 2746321 cctgcataat gttaatatcg aaattttcaa tcatttgagc taatgcctgc ggctcacgga 2746381 tcgtttcttt ctttgcgatc acgatttgcg ctccgctaat cagcggaaga tataactcca 2746441 atgctgaaat atcaaaagcg acagtcgtca cagccaacag cctgtcttct tctcctagag 2746501 aaaatgcctc ctgcatagac agcagaaaat tgcttaagct tttctgtgtc acaacgactc 2746561 ccttcggtct tcctgttgat cctgaggtat agatgatata cgcaggatgg tcaagcgaaa 2746621 ccgatacatc ctgattttcc ggcgaatagc gttttataat ctcctgtgta acagcctgat 2746681 caagcacaag ctcaggtaca gccaggtcat caggcagact ggctgctatt tcctcagtcg 2746741 ttatgatgca tgaaggtttc gcatcctcca gcatgtaaga aatgcggtcg gctggaaact 2746801 ccggatcaag ggggagatac gccgcaccag tcttgagcac accaagcatt gaagccacca 2746861 tctcagggga acgcggcagc gccaaagcga caaattgctc cggaccaatc cctttttcga 2746921 tcaacagacg cgcgaggcgg tttgcctctt cattgagctt tcgatagttg acttgaatgt 2746981 catcacacat gagagcgata cgttctggcg taagaactgc ctgcttttcg aacatgtcct 2747041 gaaggctgac cagcttctcg gattttgccg tctcattcca tttagaaatg actttttctt 2747101 tctcctctgg caacagaagc tccatttgcc caatcagcat gtcctctccg gcagaagccg 2747161 tttgcagcag ctgcaaaata cgctgctgat gaagcttaat atcagactca ctgtatacct 2747221 cgggattcgc atcaacatca attcgcagcc cgctgccgtc tgttctgtca tatacattga 2747281 ttgatagatc atcaacagga ccggctgaaa gattatgcgt tgtgccccgg acgccggcaa 2747341 agtcgagacc gtaatcaaac ggcataagat tgatttgagg gccaaataat ctatgatttt 2747401 ctcctatcaa tttcagatcg cgcctaagct cttcatggcg atacttatga tgtcgccgaa 2747461 tactgcggat ttcccgggaa atttgctgaa tcagttcaga aaagctcatc gaagagctta 2747521 ccgtcagccg gagcgggaga aggttcatca ccatagccgg tacattcagt gacgcggacc 2747581 ctatccgacc catcatgggc aggccgagca caacatcctc agagccggtc atacggtgca 2747641 cataaacagc tgacaccgca atcatgactt catgccagct tcctgagaaa tagcgcgccg 2747701 cttcttttaa cgcgtttaca tcagacggag gcagatatgc cgtatgacga agaaaactgt 2747761 tagatgttct tggcgcccga tcagccaagc tcacaacttc aggtgcatct gcaaaacggt 2747821 ccagccagaa ttgacgatcc ttctcatact gctctgatcc gcgataatct gtatcctcct 2747881 ccaaaatggc ctggagagac ccaaaggaac ggcttttagc tgtttgtcct tttataaggg 2747941 cagtatatgt acttgccaca cgctgggcta tcagggaaaa accgaagccg tcgatcgcta 2748001 tatggtgaat gcgctgatac caaaagaaac gatcaggccc ggcaataaac agagcttcat 2748061 tgaacaaagg ggcataccct aaatcaaccg gctttgctaa atcagctttc atccagttta 2748121 atgctgtttt ttccggatca ggctcagagc tgacgtcaat gacgtgcagc tgtacatccg 2748181 gagacgggtt tatcatctgc caaggcccgt ccatattttc accgaagcgg acatgcagcg 2748241 attccgcttc cttgatcacg tgccgcaaag cttcttcaaa aagagcaata ttgactggtc 2748301 cattgatttc tatatattcc gctgtattgt agattggatt gtccggatca agctgctgag 2748361 caaaccatat gccagtttgc gccccggtca aagaatattg aagatctttt gtatcaggca 2748421 tccgtttgtt taccctcctt ttataaataa tccgcgtttg gcagcacttg ctggctgcga 2748481 gttgtgagca atttctgcca ttcttcgatc gttgggcgtt cagccaattc cacgaaagtc 2748541 acctctgccc cttcacggcg ccattgttcc accaatgtca tgatccttac cgaatcaaga 2748601 ccacgatcga gcaaatcctc ttgatctgtg atgtcttccg gtgtttcttg tagaagctca 2748661 gcaatttgtt tacggatatt ctcacatgta aacacgttct ttttgccagt gtttgctgac 2748721 gttttttgaa cgtctgccgg cgcattctgc agctgatcaa gaagactgtc agtcatcacg 2748781 gtaaacgcac agcgtccagc cgcatattcc agcgccattt gatgtttttc taatgaaaaa 2748841 tcagcaactg catctcccac aaaaaaggct ttaatatcct ccataaatgc ttcacatgct 2748901 gtaacaagac agccgatatg ggcgtaaatt cctgtaatga tcagctgatc gcgtccctct 2748961 ttgcgcatca tttcaagcag attcgttctc ttaaacgcgc tgtatctcca ttttgtcagc 2749021 acaagatcat catcctctgg tgccagctcg gttataattt tctcctcata aggaccgctg 2749081 tttaatcccg ggccccaaaa gtctgtcagc agcgcacggt catccggatt ttggcttccc 2749141 ggctgtgcgg tatagacaac aggaatccca agctgaacac attgattctt cagctttcgt 2749201 atattcgctg aaagctctgt taccggagac gctcccgctg tgaaagcatc aacaaaatag 2749261 ttttgcatat cgtgtattaa caagacagcc cgattcggat caggcaccca tgatactttg 2749321 ttttgcggca tatcagatgc tgtcggcatt tgatacggct gaatggcagg tatagccata 2749381 tgaacacttc ctctcaaatt gttgttttat tttttaaatc ctgcaagaag cttctcggaa 2749441 atggcttcac ggagcgcttt tttgctgact tttcctactc ctgtctgcgg gaaggattcg 2749501 acaaattcaa ctcgatcagg gattttatat gccgccagtc cgcgctctct caaaaatgct 2749561 ttaagctctg cggcttttgg ggcttcatcc cggggaataa tgaacacaca agatctttcg 2749621 ccaagaaatt gatcaggcat ggagaccatt gccgcatcat ggacagccgg atgcgccagc 2749681 agatgatttt ctacctcttc agccgcaacc ttttctcctc cacggttaat ttgatccttc 2749741 gcccggcctt caacgacaat atagccgtct cgtgtcagcc tgacgatatc acccgtacgg 2749801 taaaaaccgt cctcagtaaa tgaagcggcg ttatgctctt ctgccttata gtaacctcga 2749861 attgtatacg gcccccgcgt cagcagatgg cctgtttcac caggttttac gtcgcgatca 2749921 tgatcatccc aaacacgcat ttcatcatat ggagacatcg gttttccttg ggtgttgaca 2749981 atgatctcct caggatcatc caatctcgta taattgacga gaccctctgc cattccgaac 2750041 acctgctgca gcgtgcagcc gaaaacagct tttaccctgc gcgcggcttc agcactaaac 2750101 ttggcaccgc cgacctgcag cacttgaagg ctggataaat catcacggcg tgaggatgcc 2750161 gcatccatcc ataccatcgc aagaggcgga acaagagcgg ttatcgtgac cttttcccgt 2750221 tcaattaaag gaaatgcgtc atctggactt ggagaaggag ataataccac tcttcctcca 2750281 gcgtataata cgccgagaac gccgggtgag ctcagcggat aattgtgtgc catcggcagc 2750341 gcggccaagt acaccgtgct gtggtcgagc cagcagacct ccacactccg cttcaggctg 2750401 tatatgtagt catcgtgggt cctcggaatc agtttcgata gcccggtgct cccgccagaa 2750461 agctggagga acgccacatc cgatgatttg acttcaggca gttttacagg ttctgcatgc 2750521 aaatcctcca gcggtaaaaa ttcctctgcc tcacctgcga caatgatgtt tttcaaagtc 2750581 ggcagcttgc tttgaacctg tctggcaagc gaacggtagt caaaaccgga ataagcgtcg 2750641 ggaatgatat atgcagccgc ttcagcaaac tcgcaaaaat atgtaatttc actgcttcga 2750701 tgagaaggca gtgcgaagac tggaagcgcc cccagacgga aaagcgcgaa aatgacttca 2750761 aaaaactctt tgatatttgg caactgcacc acaacacgat ccatctgttg aatgccgagc 2750821 ttttgaaatc cggcagccag gcgatcagcc cttgtgtcaa gctctcgata gctccaatgg 2750881 gtgtttccgc atgtaatggc aatgcgatca ccatatttgg ctgcccggtc ccttaacaaa 2750941 tctccaaacg tctcaccggc ccagcagccg ttctttcgat aggtctcagc taactcatca 2751001 ggccaaggcg taaatccttt cagcatgttg tatccctcca gcaattcatt ctgttcatat 2751061 gtgatccacg cccattgccc gcagcattgt ccgaaacttt gcggacgtct cctgaagctc 2751121 gtcctcaggc tttgaaccgg ccacaacacc agctccagca tacaggcgga gtgagcgttc 2751181 ttctgcttct gcacaacgga tggtcacgat ccattctccg tcaccggcat cgtcacacca 2751241 tccgaccatg ccggtaaaga aaccgcggtc aaatggttca atgctgagaa tcgcttctct 2751301 tgcaagatca gtcggtgttc cgcagacggc tggcgtcggg tggagcgccg ccgccaattc 2751361 aagtgcggtt acagacgggt cggaaagctc tcccttaatc acgctggaca ggtgccacat 2751421 cgtttccgtt ttgatcagtg aaggcttctc cggaacctcc agcgtccggc agaaaggtct 2751481 cagcgctgcc gcaaccgcgt cagcgacaac cgcgtgctca tgaagatcct ttgcggaaga 2751541 aagcaattca gctgcccggc gctggtcttc aacaggatca ttactgcgcg gtcttgagcc 2751601 ggctaatggg ttggaaacga cctgtgttcc catccttgaa acgagaagct ccggacttgc 2751661 tccgagcaat gttctgcggg gagacgtttc ctcctgactg gacacgtctg cggcaaacgt 2751721 gtagccatgc gagttatgct gagccagatg gcgaagcaat tcatccgtct gaatcggttc 2751781 aggcgatgtc aaatgcagcg atctggacag gacgattttg ctgagtgttc catcggcaat 2751841 gcgtgccagc ccttgttcaa caccattttt ataatcctca ggttcaggaa caggctttat 2751901 gtggtatgta tgcccagcct gctgttcctt ttcctcatga tcaaattgaa gcggtcctga 2751961 ccagcgcact tcttcaggta caacgagccg cgctgctttt acttgatcaa aaggaacggc 2752021 cccgacaaca agcggccggc tttgccctga ttgttttgcc tgacgtaacg cctctgcaat 2752081 tcggccagaa agggtttcca tttggttttg cccgtctgcc tccggtacaa tttcacatat 2752141 gcctttcgct aacagtacac gatgaggaga cgctaagaaa aaggcgcccg gctgatattc 2752201 atgaagcaaa tgctccgctt ttgtttctgt tataacgttt tgatccaaca ttctcatgaa 2752261 cctcctttaa attcagttac acgcctaagg tcgcgccgcc atctacgcat aaattatgca 2752321 tcgtaatatg ccctgcctgg ccagaaacca aaaagagcac cgcatccgca atatccgaag 2752381 gcttggctag ttttttgagc gggatccctg ttttaaatgt ctcaagtgat ccttttatga 2752441 cttgctccgc tccattctcg tcggcccata atgaccactg catgtctgtt tccgttgatc 2752501 cgggagatac aatgttgcag cgaatattgt attctgcaag ctcaaggcca aggcatttcg 2752561 taaacatcac agccgcagcc tttgaagacg catatgccgc catagatgtt cttggtacac 2752621 cggcagcatt cgatccgact gttacaatcg aacccgatct tcggtccatc atatatttgc 2752681 tgactgaacg cgaggcgtta aatacgccag tcgaattcac tgagaacgtc gcctcccatt 2752741 cctcatcgct aagcgaatgg atcagtcccg ggcgaaggac acccgctaca ttcactaaaa 2752801 tatcaatcgg ccccatttca cgttcgatgc gcgccgtgat ctcgtcaatc gccgcgctgt 2752861 ctctcacatc cgcaggaaaa gcttctgcat ggcggccttc tgctttgagg ctgctcacaa 2752921 ccttttccag cttttcagga ttataatcaa ctgccgcaat atgtgcgcct tgactggcaa 2752981 gcgtccgcgc aacagcttcg cctattcctt gggcagcccc tgttataaaa gcaatttttc 2753041 cctctatacc ctttgcattc atatcatcaa ttcctttctt cgctctaaat gccaaacaga 2753101 catccagcga aaaagactgc tgcgccttga aaaacgcaat ctattgataa tgattatcat 2753161 tatcaattat aaaaataatc atatccaaat gtcatgtgac agtcaaatat aatttcagtg 2753221 acaaatattt ttttaaaggc aaggctgagt atgtctcagc ccattgatag atgcggtccg 2753281 tcagggtgaa gcgcaaaacg cagcgccctg ctgaccaaaa caggaagaac tgaaatatgt 2753341 ccttctcctg aaaactcgca aaattctgcc cgtatacctt gttcagataa aacggccagc 2753401 cgctcataaa gctcccttgc attatcattc atccggcttt tatgatgctg ctctaattct 2753461 cctgcggcaa gcaggatatt gataggctga ttgtttttct tggtgagaga gacgaaatgg 2753521 tccgttttct tgagaataaa cggtttattc caatgaatgg acggacttcc cgcgatatac 2753581 gtttgaaacg catcgggctt tgttagcagc acctgcagca cgaaaagccc tccgagcgaa 2753641 tggccaaaga ttgtttgtct ttttttatca atctggtaat ctcgttctat ctccggtttt 2753701 aaatcctctt caataaatct gaaaaagccc tccgctccgc catgctccgg ccattctctg 2753761 ccgtcgggcc tttccggcag cttcgattgg gctgttggca ttgtaaaatc ccggtggcgt 2753821 gctgaggaga acggctccgc tgtctcatag ccaatgccga cgatcactgc agggatcacc 2753881 ccggtttttt cgggtcggcg tccctgtatt cgaacggctt ccgtcatcgt tccgaagaca 2753941 gaattggcat ccagcagata aatcacagga taaccagcgg gtggcggcgg cgtactaggt 2754001 ttcgagataa aaatgtgata ggtacggttt tcattgcgtg aagacatcat acgcacttcc 2754061 gtaccaggaa tcgtaaatgc gtttgatgtc ccgccatttg tccggtctgt tgtttgttct 2754121 ttcatgcagt acgacattcc tctccttaaa ctaaaccgca atgtatgata atgattttca 2754181 ctatcaacta gacacctcaa ataataggtt ttcttccaaa gaaagtcaac tttttcccga 2754241 ataaaaaagg caccttgatc aaataaggta cctgcagact atcaatatgg aagtaaaaac 2754301 ctaataaaga tgcgtattgt cctatttgaa atagaacctt aatcccatgt aaacctttga 2754361 ttttgccaag ggtcgcctct catgtgatag ccattccgct cccaaaagcc agggtgattt 2754421 tctttcgtaa attggatgcc gcgcagccac ttggcgcttt tccaaaaata cagatgcgga 2754481 aatacacccc gcagcggaaa gccgtgttca ggggttaaag gttcgccatt atgcgcataa 2754541 gccagaaggg aagtttccgc taagaaatca tcaagcggca gattggtcgt ccagccctct 2754601 tcagcatgta aaatgacgta gcccgcttct tcttttacac ccgctttttc cgctatatca 2754661 caagcccgca cgccttgcca cacattatca agccttgacc atcccgtgac gcaatgaatg 2754721 tcgtttttcg attcataccg tggaaaggct ttgacatctt caaagcttag cagcatcgga 2754781 tggtcaacca aaccgtatac ttgaagattc catttcgtca tatcttcgta atatgggaca 2754841 tctccggtat gaagcacagg aaatgaagtg gtgacgtttt gatttggcgg cactcttcca 2754901 gattgatcgg actgtcttgt ttttccgaaa tacatatggg cctccttttt gttaacctaa 2754961 tttaaaatca tgttgacaat ctttttgttc tttattactc tatgattgtg tatgtcaacc 2755021 taagggggaa caacgatgaa acaacgtaaa cttcgtgcgg gagatatggc gctgattggc 2755081 atgttcgccg cacttatggc tgtcggggcc aacattacat cagtagcacc ctttttacaa 2755141 gtagccggca ttccgctttc gatgcagccg tttttctgtc tcttggcagc tttgcttctt 2755201 ggcagcaaac gggcagcgat tgccatgatt gtatatgcac ttgtgggatt ggccggagcg 2755261 cctgtgtttg ctcaattttc agcaggcttc gcaccgtttg cagggaaaag cggcgggttt 2755321 attatctcat acattccggc agcatttgca gcgggatggt ttttagaacg aaacattcag 2755381 ccaagtaaaa ttcgatttct cattgcttca cttatcggaa cggcgatcat gtatctcatc 2755441 ggcactacct atatgtatct tgcactgaag ctgtggattc atacgccagt gagctacggc 2755501 acggcttggg gctttatgat ttggtttatg gtaaaagata cagcgctggc tgtgatactg 2755561 tcgtttatcg caccagcaat ctaccgctct attcataaag caaccggctt taacagaaat 2755621 cacatatcat ctacgtaaaa accgttctat tggacggttt ttttatcata acgagaaaag 2755681 gctccccagt aaaggggagc ctttttccta taaaacaagc gctgcaatcc agccaaagat 2755741 gacaagcgga atattataaa atataaatgt cggcacacaa gtatcccaaa tgtggtgatg 2755801 ctggccgtcc gcactcaaac ctgaagtcgg cccaagcgta ctgtcactgg caggtgaacc 2755861 ggcatcgcca agcgcagcag cagccccgat aatcgcaatc gttgccatcg ggctgaatcc 2755921 aagctgcatg catagaggca cgaaaatggt tgtgataaca ggaatggtcg caaaagaaga 2755981 tccgatcccc attgtaatta ataagccgac aatgagcatc agcaatgcgc ccaaggactg 2756041 actgtgtccg ataaaaccag ctgacgtttt gaccagtgac tcgacatctc cggttttcgt 2756101 caatacgttt gaaaatccgg ctgcaacaag catgacaaag ccgataaagg ccattaaaac 2756161 cattccatca gtaatcagtg agtccgcttc atcacgcttc atcacaccgc tgacaaacag 2756221 aacaatcaga ccagcgagcg cccccataat cattccttct actcccaaag tctgagataa 2756281 gtaaagctgg acgccgagtg acacaacaat ggctagaacc gcgataccaa tactttttct 2756341 cgtatatggc gatgcttctg cacctgaaat gtcttttgtt tcatattgtt tcggtttacg 2756401 gtatacgatc actgataaaa taaggccgac aaccatacct gcaactggaa taatcagtgc 2756461 gtacggaata tcagcaagcg gaacgtttaa cccggcatcc gccatattgt ccttcagcat 2756521 gccttggaag atttggccga aaccgaccgg aagcaaaata taaggagccg ttaagccaaa 2756581 tgtaattaca cacgcgatca gacggcggtc catttcaagt tcattaaaga ttttcaaaag 2756641 cggcggaatc agcaccggga taaacgcgat gtgaaccgga acgacgtttt gcgaaaaaca 2756701 agatacaatt aaaataatca gcacaatcag caccttagac agtgcttttt ttcgagaatc 2756761 ttctttattt ccgattaatt taacggaggc ttccaccatt gcgtccggaa gacccgtttt 2756821 cgtcaaagcg gcggcaaacg cgccaagcat ggcatagcta actgcaacgg tggcatttcc 2756881 gccgagaccg tctgtgaaag ctttaaccgt ttcgccaaga ccgagcccgc ctgttaaccc 2756941 gccggccaag gcgcctataa ttaatgcgat aacaatattg acacgcagca ggcttaatac 2757001 aagcataagc aggactgcga tgacgactgc attcatgatg atacccctcc aaaaatcctt 2757061 tagtttgcta atgtagtaga taaataaagt acgaacgtat cgtatcataa ccgatccact 2757121 ttagtcaact aaagatttcg gaagaaaaaa tccctgccgc atcatacagc agggattttt 2757181 cattactcgt ttttatcttc ttccaatgta aatcgctccg caagtgtagc cagtgttctt 2757241 gccataacgc cagtagcccc ggccggtccg aagcaggttg ctttattggc agtcgctgtg 2757301 cctgcaatat caaggtgaac ccaaggtgtt gactcagcga attcaccaag aaacgttcct 2757361 gccataatcg catgtccctc gcgtcccggt gaattgctga gatccgccat ttggctgctt 2757421 ttcacgcgtt ttttatcctt ctctgttatc ggcagctgcc agatcgcctc gccgcactct 2757481 tgtgcagcat cagctacctg ctggtaaaag ctttgatcat ttgtcattgc accggttgtt 2757541 tctgttccta atgccacaac gacgccgccg gtaagcgtag ctacatcgac aagaactgat 2757601 gcgccatgct gtttcgcgta tgtaatgcca tctgcaagca ctagccttcc ttcagcatcc 2757661 gtattaagga tttctattgt ttttccgctt aaagatacga tcacgtcatc cggcttcatg 2757721 gccccgccgg agatcatatt atcggttgat ggaataacgc acagcacgtt ttgttcagga 2757781 cgaagctctc cgatcgtttc catagccccg agaaccgcag ctgctcctcc catatctgat 2757841 ttcatgccaa caattccaga tttcgtttta atggagtagc cgcctgtgtc aaaggtaatt 2757901 cctttcccga ctagtccgac gacgtcttcc cattcctttt tgccctgata tttcaacaca 2757961 atcattttcg gcggttcggt ggagccttgg tttaccgcaa gtattccgcc cataccgagc 2758021 tcttccatct ctgatttctc caatatctca cactcaaaat catatttcgc cgcaagctct 2758081 tcagcatacg aagcgaggtc agtcgctgtc agcatgtttc ccggcatatt cacaagcgtt 2758141 ctagccgaat ttgtcccttg tccgtatgcc tggccgacgc gaagccctgc ctgcacttcc 2758201 tgtgtatctt catctgttac aacatacacg gcttcaattt gtttgtcagg ctcatttgat 2758261 ttatgcttat aatcctgcac ctcataggaa gcaagcaggc agctctcagc taaagcatga 2758321 gcggcatcgg ctggaggcac gtcttccgaa ataaacgtat caagcagaac agcagtttct 2758381 tgttttcgat ctttatgaat ggcttgaaaa acatgagcaa aacgttcctt cgcctgttca 2758441 aacgaataat ttgcttctct ccccaggcca acgaaataaa tccgtttcat acccgcagaa 2758501 gatggaggga atacttttga tacttgattc ggtttcgcag agacatcacc ctcttttaaa 2758561 agctgtgtca gatggccttc gagcatttca tcaatttcca acgcttttcc tgtcagctgg 2758621 cttttttgaa aaagcccgac aacaagggtt tctgtatgct ctgattgttg aaccgcataa 2758681 aacatgaggc ttacactcct aacgtaatgg gtatttgtaa tgaacaatgg tataatagga 2758741 aaaacattct ttccactata cttattttaa caaacaacag tctaagactt gcttttttct 2758801 tttgaaacac gaaggatttt tcaaatagaa aggatgtcgc cgatggaact tttaacgaat 2758861 tttcctttat tatcaagcct ggccgcaatt atttttgctc aggtcatcaa agtgcccata 2758921 cagtttatcg tgtccagaaa actggactgg tcgctggtca caagcacagg cggcatgcct 2758981 agctctcact ccgcagcggt cactgcgctt tctacaggcg tagccttgga gcatggatta 2759041 gactcctcac tctttgcggt ttccgccatt ttcgccgtca taaccatgtt tgacgcaact 2759101 ggcgtcagac gtcacgccgg tgagcaggca acagtcatta ataagcttgt tattgatttt 2759161 aaccgtttcg taaatgaagc gaaggacttc cctaaggctg cagagaaaga aaagcaaaaa 2759221 aagctgaaag agcttctcgg acatcagccg atcgaagtct ttttcggagg attaacaggt 2759281 attttactga cattggtact cgcttacttt ttcatgtaaa aaaaacgctc ctgctttcgc 2759341 tggagcgttt tattctttca ccgttttata ttgatttctg aacacttgca aagattttgt 2759401 ttcattgagc ttctcaagct catcctcggt aatctttccc gttccctttt taatcacata 2759461 tacatcaagg gtttttttgc cccattcatt gtatacatct ttgactgtct caaagtacag 2759521 atcaaggcgg tttcccttaa tagctgatcc tgtgtcggcc acaactccga gaccgtagtt 2759581 cggaatgaat aaaattgttc cgatcgggaa aacggacggg tcagcagcaa ccgtggaata 2759641 taaatcccgt ttcactttca cacctgaata tgtaagcccg tataatggat caccgggatt 2759701 tttgcccgtc gactcagctc ctgctgtgta gcctgttgct gttactcttt ggactggata 2759761 ttcatcccaa tcaaatgcct cttctaacgg ttttgtttta tcctcagccg cggacgtggt 2759821 ttgtgtttgt ttctgctgca atgcttttaa tctcagtcct gcatgcttca agtgcttttc 2759881 ctgatgttcc tgcacccatt ttgacaagtc cttcgcttca attcctgaca ctgataaaaa 2759941 tgtcgtgcca aatgcaagca gaaataaaca ggtcatcagc aaacgtctga tcatattcaa 2760001 catcattcac ctctcctccg aatcattgtt cccaagtgga gagagcatta ttcaaaatgg 2760061 tgaatgagct gaacgcataa aaaaagcttt ctttagaaga aagcggcatt taaaacattt 2760121 gatatcctct ttttctaagc atgttgatcg ctataccgga cacgatggcg ccggccaaac 2760181 cgctgactaa aatcagcaca tcagcagccg ctaatgataa gacacgatga aacaggctgg 2760241 caaaggattc tcccggcgac tggacatagc tgatcagctt ttctttgctg ataatgaaaa 2760301 ggcatacaat tggataaatc acagccataa tccaagacat tctcagcagc atgtttaata 2760361 agaaaccgat tccaaaaaac aagacaaaaa acaaaacaat tgagatgatt acgactggca 2760421 gactaatcaa cctattccac ccccctgcgt tgtttttagt gtaacgcggg ggctgaaata 2760481 aagtcaacgg ctggaaaaag aatgactgtc ttttcctgtc ccctggcaag acggacaagt 2760541 ctctgaaccg ccgagaatca attgaaaata tcctttccct gaacaaaatg ggcatgcatg 2760601 tgaagcggtt gtcgttgcag ttttcatcta atcatcaccc tttttcttaa ttttctgata 2760661 atataccata tcaagctgtc aacaataaag tcagatcatg tgacaaatct tttgatgtaa 2760721 gcggaaacat acttgttttc ctctcgttct ctttttattt tggcgttttt taataaagaa 2760781 aacccgcttc cgcgggtttt tagaaaaact tgaacttgcc ttttttcaat gtcagtccga 2760841 gtccgccaat cataaacagt gagcggttat caatgacttt tttcataaac gaagcgggcg 2760901 tgcctttcag ctttctgcca taaacaaccc caaccgcgtt atgctcgcca agagaagcca 2760961 ctgttccctt aatgtccggc ttgaattcct caagctctcc gcctttaata agcctgccaa 2761021 ggtttttagc gaccgttatg ccctgctgca ttgcaatttg cgcagtcggc ggatacgggc 2761081 gctctgtatc ttcattcata aacagcgagc tgtcgccgag aataaagaca ttgtcatgtc 2761141 ccggggcgcg gagatcaggg ttgactttga ctcggccgcg catattctca aaaccggctt 2761201 cctccacaat cggatggccg cggacacctg ccgcccatac aacggtttgc gatttgatct 2761261 gctctggttc ttcatctttt ttgccgactc tgactccttc tggtgtacat tcttgtacag 2761321 ccgttccgat cttgaactca actccgtttt cctcaagata atgtacggcg taatcaacaa 2761381 gttccggatc aaagcccggc aaaacggtcg gcgctgcttc cacacaaatg atgcggacaa 2761441 ggcttctgtc aacgtcatat tccttacaga gctccggcac gcgagcagcc agttcgccaa 2761501 gaaattcaat tcccgtaaat ccggcaccgc caacaacgat cgttaacctg tccggccgtt 2761561 tttccgcttc cgtattgtaa gtcgcaaact gcagctcaat atgttcccgc agcaggcgcg 2761621 acgtgttgat gttggcaatc ggaaacgcat attcttttaa gcctttaatg ccgaacgttt 2761681 caggcacggc gccgagcccg atgactaaat aatcgtactg caattctcca ttcgcaagca 2761741 caactttttt ctcatcaatt ttgattgcct ttacggtatc ctgtacaaaa ttcacccgtg 2761801 actggttgat tacatctttt atctgataac ggcagcggtc atgatggagc gtacccgcgc 2761861 tcgcttcatg catccatgtc gtttcataat gataattgtg tttatttaca agcgtaatgt 2761921 cagcatcatt cggcccgaca tacttcgtca gccttgtcac cgtcatcaat ccgccatatc 2761981 ctgcacctaa aatcacgatt ttgggcttat tcaatgccat cacatccacc ttctcttttt 2762041 ttgcttttgt tagacccata ataaaatcat catttgtgtt agcttcagct tattggcggg 2762101 attttatgaa atatattgaa aagttttttg tgaagtcctt acccgtagca ctattatcat 2762161 gtttatccgg ctggcccaag aaacattcag aaaaagatca tttcatttgg ttattatcgt 2762221 agcggcctgc ggaaatattt tcaagaacgg atgggcacgt tagatcctta cgattttttc 2762281 tgctgactcg tcaatttgaa cggcaatatg gtataattaa taacaatttt catttaggag 2762341 gcaattttcg tatgcgagag gatacaaagg tttatgatat tacaattata ggcgggggac 2762401 cggtcggctt attcaccgct ttttacggcg ggatgagaca ggcaagcgtc aaaattatcg 2762461 aaagcctgcc tcagctcggc ggacagctta gcgccctata ccctgagaag tatatatatg 2762521 atgtagcggg attcccgaaa atccgcgcgc aagagcttat caataaccta aaagagcaaa 2762581 tggcgaaatt cgaccaaacc atttgtctgg agcaagcggt tgaatctgtt gagaaacaag 2762641 cggacggcgt gtttaagctt gtaacaaatg aagaaaccca ctactctaaa acggtcatca 2762701 taactgcagg aaacggcgca ttcaaaccga gaaagctgga acttgaaaat gccgagcagt 2762761 atgaaggcaa aaacctccat tacttcgttg atgatctgca aaaattcgcc ggcagacgcg 2762821 ttgcgatcct tggcggtgga gattccgcgg ttgactgggc gcttatgctt gagccaatcg 2762881 caaaagaagt atcgatcatt caccgccgcg acaagttccg agcgcacgag cacagtgtgg 2762941 aaaaccttca tgcgtcgaag gttaatgtcc tgacaccatt cgtccctgcg gagctgatcg 2763001 gcgaagacaa aatcgaacag ctagtgcttg aagaagtgaa aggcgaccgc aaagagattt 2763061 tagaaattga tgacttaatc gtcaactacg gtttcgtttc atctcttgga ccgatcaaaa 2763121 actggggcct ggacatcgag aaaaattcca ttgtcgtgaa atcaacaatg gaaacaaata 2763181 tcgaaggctt ctttgcagca ggtgacattt gtacatacga aggaaaagtc aacctgattg 2763241 ccagcggctt cggcgaggca ccgacagcag tgaacaacgc caaggcttac atggacccga 2763301 aagcccgcgt acagcctctt cactcaacaa gtctttttga aaataaataa taaaaaaagg 2763361 agcttgtgtc tgcgacacag ctcctttttt atttgaagat atttatataa ttcaatgcag 2763421 ttcctacaac cagcgcaatc acaagggctg cgactaccca gatcattgcc ataataatgc 2763481 ggtcctgaat cttttgggac ttcggtgttt tttcttcgtt ttgggccatc ttattcgctc 2763541 ctttcccatg tccatgccat aaagaaagcc tggtgctgaa cgaccaagct ttgctgaacg 2763601 tatatcattc gcgttttgat ccgctctcta agaccattcg ttaaaactat gatacctaaa 2763661 ctcaccctgc atgacaagct tcggcacttg caccacacct gccagcaaat cataatgttt 2763721 gacatcctaa ataaaacaga gtacattata taaggcgaac atttcatata ttatactttt 2763781 aaatattcgt ttttaggagt gaaaaccatg gaaaacgtat ttgattacga agatattcag 2763841 ctaattcctg caaaatgcat tgtgaatagc cgttcagaat gtgatacatc cgtacgttta 2763901 ggcggacata catttaaatt gcccgtcgtc cctgccaata tgcagacgat tatagatgaa 2763961 aaactagcga tttcattagc cgaaaatggc tacttttatg tgatgcaccg atttgagcct 2764021 gagacacgaa ttgattttat taaagatatg aacgcacgcg ggttattctc ttctatcagc 2764081 gtgggcgtca aagatgagga gtatgaattt gtccgccagc tggcagaaga aaatctgact 2764141 cctgaatacg tgacaattga cattgctcac gggcactcaa atgctgtcat tgaaatgatc 2764201 cagcacctta aaaaacattt gccggacagc tttgttattg ctggcaatgt cggaacgccg 2764261 gaagcggtca gagagcttga aaatgcggga gcggatgcca ctaaagtcgg catcggaccg 2764321 ggaaaagtat gtattacgaa aatcaaaaca ggcttcggca caggcggctg gcaattagca 2764381 gcgctgcgct ggtgtgccaa ggctgccagc aaaccgatta tcgcggatgg cggcatccgc 2764441 acccatggcg acatcgcaaa atcaatccga ttcggcgcaa cgatggtcat gatcggttca 2764501 ctatttgccg gacacgaaga atcgccaggc caaacgatcg aaaaagacgg aaagctttac 2764561 aaggagtact tcggctcagc ctctgaattc caaaaaggcg aaaagaaaaa tgtcgaaggc 2764621 aaaaaaatgc acgtggcgca taaaggctca atcaaggata cactgattga aatggagcag 2764681 gatcttcaat cttctatttc ttatgcaggc ggaacaaagc ttaacgccat ccgcaatgtg 2764741 gattatgtga ttgtgaagaa ttccattttt aatggggata aatattaatc ataaaaaaac 2764801 gccaagtcag cggttctccg cttgagttgg cgttttctgc tacttcttca gcaaagtaag 2764861 cttatatttg ctttttgagt ttatcttcca tcagttctgc catttgtttt gcatttggat 2764921 tttcttcatt ttgcaactgt tcaatgacgt tcatataatc cgtttcattt cggttctggc 2764981 ttaatttata tgccgcttga atgtcttcca ccttaatctt aaatccaaca atacctttca 2765041 attcactttc taagagtttt ggagaaagct tatcccataa cacaggattg tcacgatgtt 2765101 tttcgtattt ctccaacatg attgttaatt cttctgctaa ttcatctttc tctaacatac 2765161 ttgcttttcc atacatgtgg acagcctgat aattccacgt cggaacattt tcgcgcgaat 2765221 accaggaaga agaaatataa gcgtgcggtc cctgaaacat cacaagcaca tcttcacagg 2765281 cttcaaacgt tctccactga ggatttccat aagcgaaatg ccccgtaata tagtaatgat 2765341 cgtctttttt attgaatcct aacggcaaat gtgtggcaat tggttttcct tgttctgttg 2765401 tgacaaccgt accaaaggag ttttcttgta caaaattcca aatttcttca gcatttgtga 2765461 ctttaaaata ttttggaata tacatcatca tccacccttc gaaaaatatt atatgagtgt 2765521 tttagccatg attaaatccg tttgttcttc atcacccata taaaatgagt gggcgccggt 2765581 ctgaacaaac cccattttct tataaaaggc aatggcattt tcattttttt cccacacacc 2765641 tagccaaatg ttctttttat tacgttccag cgcaatttct atcgctttat tcagcagatg 2765701 tttgccaagc ccatgttttt gaaagctgtt ctttatataa attctctcga tttcaagtga 2765761 ttcagcaccc atttcttcag actgagcatc atcgatattg acctttacat atccagcgat 2765821 ttcatgatca aagtaaataa aaaagaattg cgaagacata ttagataact ctttttccag 2765881 ctgctcagtg ttaaatgcgc tttctaaata ggctttcata ttttcaggtg agttctgttc 2765941 tttaaaagtg tcattgaatg tttcaatact caattgttga agtgtttgta aatcttcccg 2766001 gctgcatttt ttcattttta cactcattgt tcggattcag cccctttatt taaaattcaa 2766061 ttgtcttgtg tcccttttat atatttaaac acggaacaca tactgacctt gttaccattc 2766121 caaaaatctt cttcatcacc aactccctat cgtgattttg ttgtaaatgc aataaaatat 2766181 actccgcatt aaatatatcg taactttgct gtatttacaa caaaaatcaa acaacaaagc 2766241 agcgtttctc ttgccgaagt tcccggaact ctctgcatca tttccccata ataaaaacgc 2766301 ctcccttaac gatgatttat cgctaagaaa agcgtcagta atagttgcta tccgttttta 2766361 gtgcttagca ctcttcaggc ttgcctgcat tcgttgctgt tctgaacgaa gaaccgcagc 2766421 cgcatgaagc gatggcgttt ggattgtcga tggtgaagcc gccgccgagc atggattgtt 2766481 tataatcaat cacggtgccg ttcatgatgt caaggctttc tttgtcaact agaacagtga 2766541 tgccgtgctg atcaaacaca ctgtctgatt cactcttttc atgctcaaag cccatgccgt 2766601 aagaaagtcc gctgcagccg ccgcctttga cgcctacacg cagaaacgcg ttttcttctt 2766661 catgctcttt catcatatct tttatatgca aagctgctgc ttctgtaatt gttaccgggt 2766721 tgctcatcat tatgaacctc cttttaaaaa ccggttgctg tcttttatta taaacatgat 2766781 cgttccaatt ctcaaacaag gtgttttaca agaaatagac accctcacaa acggtttcag 2766841 ccggccctgt catcattaca tggccgttat ctttccagtt tatcaccaaa tccccgcctg 2766901 ctaaatgcac cgtgatgtct tgatttcgct ttgatacgcc gtttaataca gatgcgactg 2766961 ccgctgcaca tgctcctgtc ccgcatgcct gagtaatccc tgatccccgt tcccagacgc 2767021 ggaaatgcaa ttcttgttca ttcacggttt caacgaattc cacattgatg ccttccggaa 2767081 atctcggatc tttctcaatc accggcccca gtgtcgttaa gggtgcctgt tcaatgtctg 2767141 cgatcggaaa aacgatatgc ggatttccca ttgaaacggc agtgcctgtt agttctactt 2767201 caccaaatgc catcgtttca ttgattgtgt gctcttcccc gccgtcaagc ataggaagct 2767261 cggattttgt caagcgcggt tcgcccatat cgacagtgac cacattcact tttccgtttt 2767321 cgacttgaac ctccgctttc acaagcccgg agagagtttc aatcagaaaa gatgtttcct 2767381 caaccagctt atgctcatat gcgtattttg cgacgcagcg caggccgttg ccgcagtttt 2767441 tcccttcaga cccgtcatta ttaaaaatcc gcattttaac aggcgcttgg tctgatgggc 2767501 atatcaggat cattccgtcg gatccgatcc ctgtataaac agaagaaacc tgaattgcaa 2767561 tctctgacag tttttcttct ggaagctgtt cttcaaattg attcacataa atataactgt 2767621 ttcccaggcc gtgcattttg gtaaatcgaa atgagttcat aggtgcctcc aacttttttt 2767681 ctttttctta gtataaaagc tattataagc ggacacaata caattatccc ccgtttttca 2767741 tacataaaag ctccttgcac tgacgcaagg agcttttatc gtttatataa acatgccggc 2767801 aatggctgcg ctgagcagat tggctaatgt tcctgcaaga acagccttca ggccgagacg 2767861 tgcgatatct gaacggcggc tgggcgctaa accgccaagc gtaccaagca taatcgcaat 2767921 tgatgaaaaa ttggcgaatc cgcataacgc gaaactgata atggtagcag ttttcttaga 2767981 aaactcgccg atgtgcgaac cgaagttaga ataagcgaca aactcattca gcaccaattt 2768041 ctggccgata tagcttcccg cctgcaatgc ttcatgccaa ggcacgccaa tcaaaaaggc 2768101 gataggagaa aacacatagc cgagaatgga ttctaatgtt acgcctttta aaccgaacaa 2768161 gccgaaagcc ccgccgagaa taccgtttac tacagcgatt aacgcaacaa acgcaagcag 2768221 catcgcccca acatttaacg caatttgcag tcctgttgac gctccctttg cagctgcgtc 2768281 aatgacattg gctgcgcctt cgccttcatc cattttgaaa tcgcttttta cggtttgcgt 2768341 tttttccgtt tcgggtataa tcaatttacc aaagactagt ccagctggag cagccataaa 2768401 gctggccgcc agcaagtact caatcggaat accgagaagc gcgtacccaa acaaggtaga 2768461 tcccgcaact gccgatagac cgctcgtcat aatcgtaaac aactcagagc gcgtcagccc 2768521 ggcaatcagg ggtttgatca ctaacggaga ttctgattgt cctacaaaaa tattggcagc 2768581 agccgccaga gattccgttt tgcttgttcc aaggagcttc gacaatccgc cgccaatgac 2768641 acggaaaacg agctgcatga ttttcaaatg atataaaact gcaatcagtg ctgagaagaa 2768701 aatgataacg ggcagtacac ttaatgcaaa tgccggactg tctccgacct ttagaagcgg 2768761 tccaaaaata aaactgatgc cttcattcgc atagtcaatc agaagctgta cacggcttga 2768821 aaaccataaa aaaacagcgc gtcccgcttc ccatttcaac acgatgtatc caaacgccac 2768881 ctgtgtgcat aaaccaacga tgacggttct tatcttaata ttgcttttct tttctgaaaa 2768941 taaaaacgcg atagcaatga tcgcaactgc gcccagcagc ccccacagaa cattcatgaa 2769001 tactcgtaca cctcttaaat tttatttaaa aaaatatctt ttatacgata acaataatat 2769061 tttttgatgt ctacacattt ttttagttct tttgtacggc aaaataaaaa agggcctgtc 2769121 caggcccttt tctttaaaac attggatttt cttcaataaa ggtatatata ttctcaacaa 2769181 gctcagcagg cgtttcaccc atgacgactt ctccgtttac cagagcgaaa agcgattcca 2769241 tacatgtccc gcagtagctt aagcagccat attcaaggac atcaaggttg ggatccttct 2769301 ccaaaatcgc ccgggcttcc tgagagccgt gagccagatt gctgacacaa aattcaatca 2769361 ttggattcat gcggtttcac ctcacatatg tccattatcg cgaatttttc actattcgtc 2769421 aaagacaacg gatgattcaa aatttattat cgtaacatat tatttctcaa ataacgtttt 2769481 actaatttgt gttttcaggc taaattgtag gttattttga aactattatt gtgattttag 2769541 atcaaattcg atataattct agatgttatt ttacatagtt cgtattttct tcaatgtatc 2769601 tatcatactc ttcggattaa aggggaattc aaatgaaaaa attggtcttg atcggcggag 2769661 gttacgggaa catgcgcgtt cttcatcgct tattgccaaa ccagctgcct gatgatgttt 2769721 caatcacgtt aattgacaga aatccttatc actgcttgaa aacagaatat tatgcccttg 2769781 ccgcaggcac aatttctgac catcatatca gagtgtcatt cccagagcac cctcgcctgg 2769841 atgtccaata cggtgatatc acatcaattg atattgtaca aaaacaagtg ctgttccaag 2769901 atcgtgaacc gatttcttac gatgacgcca taatcgggct cggctgtgag gataaatatc 2769961 acaacgtgcc gggagcgcct gaattcacct acagtattca aaccatcgat cagtcccgcg 2770021 aaacctacca aaagctgaat aatctgagcg ctaatgccac cgtcgccatt gtcggagcgg 2770081 gcttaagcgg cgttgagctt gcaagtgaat tgagagaaag ccgtgatgac ctgaacatta 2770141 ttttgttcga ccgcggtaat ctcattttat caagctttcc cgagcgttta agcaaatatg 2770201 tgcaaaaatg gttcgaagag cacggtgtcc gcattattaa cagggcaaat atcacaaaag 2770261 tagaagaagg cgttgtgtat aaccacgatg atccgatttc tgcagacgcc atcgtgtgga 2770321 cagccggcat ccagccaaac aaagtcgtca gagacttaga tgtggagaag gacgcacaag 2770381 ggcgtattgt attaacgcct catcataatc ttccaggtga tgaacatctg tacgttgtcg 2770441 gcgattgcgc cagtcttcct catgcaccga gcgcccagct ggcagaggct caagcagagc 2770501 agattgtcca aatcttgcaa aaacgctgga atggagaagc cctgcctgaa tcaatgccgc 2770561 agtttaagct gaaaggcgtc ctcggttcac tcggaaaaaa agccggcttc gggcttgttg 2770621 ctgaccgtcc gctgatcggc cgtgttccgc gtatgctgaa atccggcttg ctgtggatgt 2770681 ataaacacca taacggttaa tgatagagaa gaaccgctga tcaagtcagc ggttttctgt 2770741 atacccatgc ttctccattt cctcataaac gtcttttaat tttggattgc cttcaccgac 2770801 aattttgtct tctacaagca caagcggata aaaatactcg tcatttctga ttttttccgc 2770861 aagctctttc gcatgttcat tgtcaggcgg ctcatgaata tcgatgtact gcatctcaaa 2770921 aggctgattt ggatattttc ttttcagcgc agcctcaagc cactcgtatg tatccttggc 2770981 tgtcggcata tttacacagc tcgcacaaac gttttctgcc ccgtacacgc ttagcatgac 2771041 tggtttcatc acttgtagac gcccccttct cctatgtaag tcctttcttt taagtataca 2771101 gagcctaagg gcgtttttat agaaaaaaac cgtttttgtg ttgaagtctg aatgtgctat 2771161 aatagggaaa gcaactttgc aaaccaaaca atagattttt attgttacac tgaatataat 2771221 ggttttatga cgacgaaagg agcgaatgtc atgactgaag ttgaaatgaa agaacaggtg 2771281 caggaagtac tggacaaact tcgtccgttt ttacttcgtg acggcggtga ctgtgagctt 2771341 gtagacgtag atgaaggtat cgttaagctt cgtcttctag gcgcatgcgg cagctgccca 2771401 agttcaacaa ttacgttgaa agccggaatt gagcgcgctc ttcttgaaga agtgccgggt 2771461 gtcgttgaag tagaacaagt cttttaataa agcagccagg ctgatatttg atcagcctgg 2771521 cttttttatt agagatgttg atcaaaccat gagctgatat aattcaggcg cttgatccgc 2771581 tgtcttgggt gtccggtgcg tgataaattg tgcgatgcat tcggaaaacg gacaagcttg 2771641 gtttccttgc ccattttttt cagagcgata aacagctgct ccgcctgctc gatcgggcat 2771701 cggtcatccc gctcgccatg cagtatcaaa agcggtgtct ccacgtttgc tgcgtatttt 2771761 aaaggagacc ggtcccagag cttttctgtg tcctcaaaca tgtcatgctc aagctgccag 2771821 tctgtaaaga aatagccgat atcactgacg ccgtgaaagc tgatccaatt tgatatcgag 2771881 cgctgggtaa cggcagcttt aaagcggttc gtctgcccga cgatccagtt ggtcataaaa 2771941 cctccgtagc ttccgcccgt gacaccgagc cgcttaggat caatatgcgg atctcgtttg 2772001 atagcctcat ccacagcctg catcacatcg tcataatcct ttcccccata atctcctctg 2772061 accgcattca caaattcctg cccgtagccg tggcttcctc tcggattgat ataaacgacc 2772121 gcgtatcctt tcgccgccag cacctgaaac tcatgaaaat atgtatgtcc gtacatcata 2772181 tgcggaccgc cgtgtatgtt aagaataagt ggatatgttg tctcaccttc catttgtgca 2772241 ggcctcatca gccagccgtt caccatcacg ccgtcttctg tagcatattg aatctcttca 2772301 ggtattgata tcgtatgctc cctgacaaac ttgtcattcg cgccagtcag ctgtttctct 2772361 tcctgtccaa gcgggatact gtaaagctca ctcggtctgt ccggctttgt cacactggca 2772421 ataaagtgct gttcatcagg tgaaagagaa aagctattga tgtactcttt ttccagacga 2772481 atcggataca caaggccttc aatcgaaata taatagatgc ccgtactgcc ttgatctgtg 2772541 ccgatgacat aaaacccttg gctgtccttt gtccaaatcg ggcgctgttc agcaccaccg 2772601 atcaatgaat ctccaatcag cgcatccgct aaatgaacgt ccagcatctc agtaagacat 2772661 gtgaggcggc cttgttcgat atcatagagc cacgcctttg agagcgtagc attcttatat 2772721 tccttttcat ttccaagcaa agcaagatac cttccgtctg gtgaaaatga gcttgatccg 2772781 aatgagccgc gatgaggtgt aacctgctta agatctccag actccagtga cattatgtaa 2772841 acatcatgcg gcttgctggc atcatctgtt tcagttaaat tagctgagaa aacaagccat 2772901 ttgccgtcag gagaaaaagc aggatcacca tgatcagctt tgtgacttgt cagctctttc 2772961 atctcacccg actttacgct gacaagcaca agctgggcat acgcacctct cgtcagccct 2773021 ttgccgtccc gtttgtagga gaggccttgc acttcaacag gttcatagct gtcctgctct 2773081 gttttttctc ggtcatcaat gctttccccc tctcccaaac tgacagtgac cagaatcgat 2773141 tcaccgtccg gggaccatag cggctttgac acgccatatg ggatatcagt cagttttctt 2773201 gcttctccgc cttcagtgct catgatataa agctgtgccg catcgccttc tcgatcagaa 2773261 ataaaggcaa gcgtgcgccc gtccggagac catcttgggt cggtgcttcg cttttctcca 2773321 tgtgtccaag gaacagatcc tcccgttttc gtttcataga tccatatatt tgatgtatac 2773381 gaatctttct cttgatttac ttgtgatttt acatatgcgg cacgggtacc gtctggggcg 2773441 tattgaggat cggtcacaga gacaatcgct gtgatgtcgt ctgcggttat cagctttttc 2773501 atattcatct cctccttttt acatgtattt cgtttttcta aataaaaact cctttatctc 2773561 cagcaaaaaa aagcgccctc cgctgacgct gaggaacgct tggcatgatc tatacacttt 2773621 ttacttgata taaaggattt cgctctatta tacttccctc tttcggaacg gtcaaagcgt 2773681 ctacttcaca atgagggaaa tgaagcgcga gctgttcttt tagctcttct ccctttcctt 2773741 tttcggtcat gacgagaatc gttgggcctg ctccgctgag agccgttcca tatgcgccct 2773801 tcatctcggc gacgtgctct acttttgaca gctcaggcac aagcatcgcc cggtacggct 2773861 gatggaacat atccttcttc atgattttcc cgacaagcgg ccaatccttg gacatgatcg 2773921 cagcaatgag gatattgctg acagcacttg cttttacggc atcggcatat ggaaactcct 2773981 tcggaagcac gtctctcgcg tctcttgtca gcacttcata aaaaggaatg acaacgacta 2774041 cgtcaatgtc agcattcggg acgcggatca tttgggtctc gtcatcctca tgcaggccga 2774101 tcacaagtcc gccgacgaga gaagcgccag cattgtccgg gtgtccttct tctagactcg 2774161 ctaaatgcag cttgtccgct tcagacagct ttaagccgca taattcatca gccagttcaa 2774221 tggccgctac aatcgctgcg gcgctgctgc caaggccgcg tgcaagcggg atgtcgctcc 2774281 acaccttcac atggacagga ggcatttctt ttccgtacaa atctgcggtc cgtttagcca 2774341 cttggtagat caggttatct gtacccgccg gaattccggc gactgtttct gtttcagcct 2774401 caaaagacca tttgtcgctt tcaaagacgg tcagcttcaa atatctgctg agcgccattc 2774461 cgactgaatc aaagccgggg cctaggttag ctgtgcttcc gggaacagtg acagagaaca 2774521 gcatgtcggc ttcgttcata cacgggccgc tccttttaca tattcaagga tgctgtcttc 2774581 atcagtcggc aatgtgacag gcttgatttc tgaaatgtcg accgctgtgt tcggatcttt 2774641 cagtccgttt cctgttaaca cagctacgac cttgctgcct ttcggaattt ctccggattt 2774701 cacctgtttc agcactcctg cgatagacgc gcaagaacct ggttctgcaa acacgccttc 2774761 tacacgggcg atcagctgat atgcgtgaag gatttcatca tcagtgactt cgtcaatttt 2774821 cccattggat tcctcggctg cctttacagc tttgtcccag cttgccgggt ttccgatacg 2774881 aatggctgtc gctattgttt ccggattttc aatcacttca ttgcgcacga ttgccgccgc 2774941 accctcagct tcaaagccgc gcattttcgg aaggcctgtg ccgtttttct catgatattc 2775001 cttgaagccc ttccagtacg cagtgatgtt tccagcattt ccgaccggga tcgctaaaac 2775061 atcaggcgct tcccccagct gttcgcacac ttcgaaggca gcagtttttt ggccttcaat 2775121 gcggtaaggg ttgactgagt tgacaagggc aatcggtgat ttctcacaga tggaacggac 2775181 aattttaagc gcatcgtcaa agtttccgtc aattgcgata atctcggctc cgtacatgac 2775241 agcttgagcg agttttccaa atgcaatttt tccgttcggg atgatgacaa tgcatttcat 2775301 gttagcacgg gctgcatatg ctgccgcagc agcggaagtg ttacctgttg acgcgcacat 2775361 aatcgtgtca ttgccttctt cttttgcctt tgccacagcc ataaccattc cgcgatcttt 2775421 aaatgatccc gtaggattga cgccttccgt tttgacatga agctcaattc cgagctgctc 2775481 agacagcttc ggcaggtgaa taagaggtgt gtttccttca tgtaaagtta gcgccggtgt 2775541 ttgatctgtt acaggtaaaa attctttata ttgatggata agtcctttcc acattagctc 2775601 caaccgttcc cttctacacg atatgtgctt ttgacttctt gaacgacttc caaatcattt 2775661 aggttttgca ggatatcact gaaatcagct tctgatgtat gatgtgtgac aattacgatt 2775721 tcagctaact catcatggcc tttaattggc agctgaagga ttttttcaaa gctcacgccc 2775781 cgctctgaga acacagatgt aattttcgag aatgaaccaa cctcatcttt tacatgaatt 2775841 cttaaaaact gctgtgcata aatgtcagac ggcgatttca tgtttttctc atattgcggt 2775901 ccgacaaagc tgttgccggt tacacctagg cgcatatttt tcatgacagc gacgaggtca 2775961 gaaacaacgg atgtcgctgt cggcatgctt ccggctcccg gcccgtagaa catcgtctca 2776021 ccgacagcct cgccgtatac ataaacagcg ttaaactcat tatgaacagc agaaagcgga 2776081 tgatggtcag gaagcagtgt cggctgtacg ctgacctcga ttttgctgcc gtcacgctga 2776141 gcaatcccga tcagcttcat tgtatagccg aggcgtttgc tgaagctgat gtcctcgtct 2776201 gtaatttggg agatcccctt tactttgacg tcttccagat ccacgttcat cgagaagccg 2776261 aggcgcgcca atatcgccat tttccgtgcg gcgtcaagcc cttccacgtc agaagtcgga 2776321 tcagcttcgg caaaaccgag atcctgcgct tccttgagca cttcctcgta tgggcttttc 2776381 tctttgatca ttttggttaa gataaagttt gttgtgccgt tcacaattcc catcattttt 2776441 gtaattcgat ctgatgagag gccttcctct aacgtgcgca gaatcggaat cccgccggca 2776501 acactggctt caaagtagat atcgcatcca ttttccttcg cttcggcaag cagctcggag 2776561 ccgtacacag ccattaagtc cttgtttgct gtgacaacat gctttttcga tctcagcgcg 2776621 tcgaccaaat attgttttgt ctgttcaacg ccgccgatca cctcgatgac gacatcaaca 2776681 tctggatcat caatgacatc atacacttct gtcgtgagca cttccttcgg caaatctact 2776741 tctctctttt tctctaaatc ttttacaagc acttttttta tcgtaaccgg acagccgacc 2776801 tgatgcataa gcttatcctg atggtcttga ataattttaa cgacaccgct tccgacggta 2776861 cctaaaccta aaagccctac acgaatcgct ttcaaaaaaa ctccaccttt cttttgattg 2776921 tcctcttgga aaagacaatt gttaactcaa cacagacata taagttacaa acattatata 2776981 agcccgctcc tgttttgaca agacatcatt aggctgaatt ttgcgaatgt aaacgcttaa 2777041 cgcattgata tgacaagatt ctttattttc taattatttt tgtcagattt tctcctcacc 2777101 ttgagctgcc tttgccgagc cagctgacgc gtggaacaaa cagcttctgc gcccgcatat 2777161 tcatgaattc ctgcgctgta ttgagaaatt gttcataacg cccacagtca ttaagaatga 2777221 agtcaagctg ttcttcaaaa taatgctttt ctgattctga tgacatgtaa tagctttcta 2777281 cgatttcaaa ataatgaagc gggaaaagca gacggctgta taaaaggcgt ttcgaaaatg 2777341 aagacagcgg tgtgacttgc tcgtattcct gtaaaaagag aaagccctgc tgattaaaat 2777401 cttgtctgtg atgcaaaaac gtatgcctca tatattcagc caaatcacgg gaagcgtggt 2777461 caaacaccca atccgccgga atcctgatca atgattccgg tgaccatgta tgcctttcca 2777521 tccgctgatg gcatatcgtt cctgaatcag cggcttgggg cttgtcatcc agctcagtgt 2777581 ccactaaata ttgtatcgcg ttttctgaca gtcctaaata atatggaaat gattcgatca 2777641 tttttttatc gaatggctca tgcggagggg tctgaacctt tctctgccaa aatgcttcca 2777701 gctgatcaat tcgttttccc cacagatcct tccactggcc gattcttccg gccgccttca 2777761 cctcatatgg atatcctcgg ccttttcggt gaaattccgc aagctccgct ccaatggaga 2777821 acgccctgtt tgaataaggg ggggccgcct tcagcagagc gtacgttttt ccctcatgtt 2777881 caaatgtcag ttcaccttct tttgtaaaga taaaaaccga aacgtatggg tcactttgtt 2777941 cttgtaaata ctgactcatg taataaagct ccgccagctc tgtttctgag aattgggaaa 2778001 cggggacaat cagaaagtat gaattaggcg tctgaaagca ttgatatgtg tgctggtaca 2778061 tggaaagctg cctgatgtga atgccgtatt tttcttttat tgtacctttc accatgatca 2778121 cctgcctgtt gaattagggc tcatcacatc gtagtcatac acagccggaa ttatgaatac 2778181 atattttaat ccgaagaagg cgcaagaaaa agtcgtaaac ttctcaagca ttttgtataa 2778241 actagtaaaa aagattgggt gaagctgatg tcagaaaacg aacaattcag tcagatggaa 2778301 gctaaagcaa gagcacggat gaaggagcgc ggcgttgagg tatcagacat tgccgagctt 2778361 gtcttttttc tgcagaaaaa atatcatccg gatttaacca ttgatgaatg cacgctgaac 2778421 gtcaatcgtg ttctcgcaaa acgcgaggtg caaaacgcga ttttaacggg cattgaattg 2778481 gatgttcttg ctgagcagaa aaaattgtct gaaccgctgc aaacgatgct ggaaatagat 2778541 gaaagcctat atggagtaga tgaagttctg gcattttcca ttgtgaacat ttacggatcg 2778601 atcgggttta cgaactacgg ttacatcgac aaagaaaaac ccggaatcct taaacgattg 2778661 aatgataaat caaccggtga atgccatacc tttttagatg acatcgtcgg agcgatttcc 2778721 gccgcggctt caagcagact tgctcaccgc gcgcggcata cagaataagg gcaccctttt 2778781 agggcgccct tttttcaaat gtatggaatc cattcagtca gagagtcaat ggcgtgagtc 2778841 ggtttttcca tatcgtctgt catatgttct cttttcgtta cgcctgtgtg aacgagcagc 2778901 gtatccatac ccgcgttaat gccggccata atatcagtgg cgtagttgtc gccgaccatg 2778961 agtgtttcag acacatctgt gccgagaacg cgcatcgcct gctccataat aattgattcc 2779021 ggcttgccga taaatacagg ctgtacacct gtagatacgg ttaacaccga tgtcagtgag 2779081 ccgtttcccg gcaggagccc tctttcagtc ggaatcgcaa tatctccgtt agtggaaata 2779141 aagcgggcgc catttctgat tgccaggcag ccaacagcaa atttttcgta tgtaatggaa 2779201 cggtcgatgc caacaacgac aaaatccgcg ttttctccgc caaatgtcag gccgttttct 2779261 tcaatcgcct ggcggattcc ttcctcccca atcacataca cagacgcgtc ttttttctgc 2779321 tgtgcaatgt gctgggcagt tgccatgctg gtcgtgaaga cctgctcttc tgttgccgga 2779381 atatcaaaag acacgagctt gtccgctacc tgcttcggtg tgcgcgaaga gttgtttgtc 2779441 acgaaaagat aaggaacgcc gcgatctttc agcgttctga caaattcaca cgcctcctcg 2779501 attttttccg tgccattgta catcgttccg tctaaatcaa ttaaataccc tttatatgtt 2779561 ttcatatcca acactcctgt ggctttccag ttgttattta aacgcggaaa caggtcctag 2779621 ctctgtttcc aaatagcttc tgatccgttt cgggaagtcc tgaagagctg tttgatgcgc 2779681 cttgatcagc ctgtaaagct cgccgctgtc agcgagcaga tactgttgaa ccaacgtttt 2779741 gcggtaggcg atcaattttt tgagctcatc accctctttt tccgtgacaa ctttctcatc 2779801 aacaagtata tccataatgt cgtcatagct gcccgggtcc cgcataataa agccgtcaat 2779861 catgtcattg cctgtatcca aaatgcattc gattaacaga tggcctatac gctgaagtgc 2779921 caattccccg atttcagact gccagtctgt ttgtgagtca aatagcgcca gctggtgctc 2779981 gaagaaccct agtgtttttt cgattttgct tctgtcaaca aaatacatga cagcatcccc 2780041 tttgtgtata tttattttct gatccgtttc aagacaaaat acgcacagcc gaaattgcag 2780101 tattcgtaaa tatattcatc taatgtgctg attttcgttt cgaaggttgc cttttgattc 2780161 tggtcgtcaa agaagccctt gagccttaac tgaccgtatc cccagtctcc cacaatataa 2780221 tcgtatttat ttaatatatc ggagtagcgg gctttaaaag cctcttcgtt gaagccgtct 2780281 ttgaaattgt gcaccaattc aaattcggca ttttgaataa gaatcatgat ctcacctctt 2780341 ttttcactca ttcctatcat aattcattgc cccgtcccca tcaattgcta aagaataaat 2780401 catgcgattt ggctacccta cacatgagga gggattgata aatgaaacga accgctgtca 2780461 gcctctgcct gctgaccgga ctattatccg ggtgcggagg cgcaggattg gataatgccc 2780521 aaaatgtccg gaatcagacg cagaatcaaa ccaaacccat tcatgtgtcg gaccgcaacg 2780581 aggcttttaa caggcataat gagaacgaac aatttggcta tgtccgctat caaaaagaac 2780641 aatttgacgg agaacagcag aaaacgccgg tgatgaaccg ggaagaaacc gctcacatga 2780701 tatcaagttt aacggttcag ctcccccata ttcaagatgc tgcgacattg gtgactgacc 2780761 gagaagcgct tgtcgtatac aaaaccgatt ctaaaaaccg ggagctgacc gccgatcagg 2780821 tgaaaaaaac agcggcttct gtgataccgc gatactatca cgtgtatatt tccgataatc 2780881 caaaccatat gcaatccgtc gaaaattaca gcaatctcgg ctctggttca agggatatta 2780941 gagagatcat gtcggggacg attcaagaaa tgaaaacctc cccgcaagga agccctgtct 2781001 cagagaatga aaatgccaat ggagaaacgc gtcaggacat gaaaatcgat aggaatgaca 2781061 aaaacgccag atgatctggc gttttggcat tatgcttgtg cttgacgctt tttagatgct 2781121 tcgtttactt gttcatccgc atggtaagag gaacggacaa gcggaccggc ttcacaatgg 2781181 ctgaagcctt tttgcatcgc gatttctttt aattctgcaa attcatcagg atggtagtat 2781241 ttttggactt tcaagtgttt cttcgtcggc tgcagatatt ggccgattgc cataatatcc 2781301 acgttgttcg ccaagaggtc gtccattact tcaataatct cttcttttgt ttcgccgagt 2781361 ccgatcatga tacttgattt tgtcggaatg tcaggctgca tttccttcgc acggcgcaaa 2781421 aattccaatg aacggtcgta cgtcgcacgc gcgcggactc ttggcgtcag gcggcgaacc 2781481 gtttcgatat tgtgattcag gatgtctggg cgtgtatcca tcaaggtttt taggttatcg 2781541 tagtttccgc ccatatcaga cggcagcacc tcaattgttg tgaacgggct ttttctgcgg 2781601 atcgcacgga cagtttccgc gaaaatgcct gccccgccat ctttctgatc gtcacgcgca 2781661 acagccgtaa tgaccgcgtg tttcaaattc ataagcgcga ctgaatccgc tacgcgttcc 2781721 ggctcttgca gatcaagctc agttggaagg cctgttttga cagcacagaa acggcatgct 2781781 cttgtacaaa cagaacctaa aatcataaat gtcgctgtac gtctgaccgc ccagcattca 2781841 tgaatattcg gacactttgc ttcttcgcat acggtatgca ggttgttttc ccgcatgagt 2781901 tttttgagcc ctgtatagtt ttcatttgta tttaatttaa ttttaagcca ttcgggcttt 2781961 ctgaggtgtt cgtctttctt tgccaattcc catcatctcc aatatccaat atactcaatt 2782021 tctgacacga aacattctga aaacgagaaa ggtgcaggtt ttagttctgc aacaaaaata 2782081 atgtttttct aactaaagaa agtcttttct ttagacactt taacatagga aaaatttctc 2782141 gacaagggaa gatgattact gacattttta agccgggttg ccgcaaacta tgtgtattca 2782201 atatgaaagg agattatttt gtgaaagttt tgttatccgc tcttcttctc cttttgtttg 2782261 catttgagcc ttctgcgtct ggaaaaaaac tttcagatcc agtgctgtcg aaacggatgg 2782321 aattatatca taaaatcgaa gctgtgacgc agatcccttg gtatgcgctc gccgctgttg 2782381 atcaatacga agaaaacgtg cggagcaacc ggaaagatct gcctgaaaag gcgggaatca 2782441 tcagcatcta tatacccgat gatatctgga gcgggcctga aaacccgaat ccgaaagacg 2782501 atgcgccgtt aagcattaaa gtgtttgacg gaatcggaat ggatggcgat ggagacggga 2782561 aagccgaggt cagcaacgat gaagatatct tgtatacgtt cagccaatac ttactgtcgt 2782621 atggcacaga tgaagacaac atccggatcg ggctttggaa ttattaccgg cgtgatcaga 2782681 cagtggggat tatatctgaa ttcatgaagc tgtttaaagc ctacggccat attgatctgg 2782741 gcgagcatgc attcccgctt ccgatcagaa ccgattacag ctaccgaagc acgtggggag 2782801 atgcccgcgg cttcggtgga aggcggattc atgaaggtac ggatatcttt gcccattacg 2782861 gccttcctgt caaatccaca tgttacggcg tagttgaaat gaagggctgg aaccgcttcg 2782921 gaggatggag aatcggcatc agggacatta acaatacgta tcattatttt gcccatctca 2782981 atgggtttgc caaagggatt aaaacaggac aaatcgttga gcctggccaa gtgatcggat 2783041 cagtcggcag ctccggatac ggcccgccgg gaaccgccgg gaagttcccg ccgcatctgc 2783101 actatggcat gtacaaagat aacggaagaa ccgaatggtc atttgatcca tacccgcatt 2783161 tgagggcgtg ggagcgatat gaataccaaa aaaagaagta acaaaaagcc gcctcttcaa 2783221 caggcggctt atttgctgct tttttctttt tttgaatcgg caccgttttc tttgctgctc 2783281 ggaagctgga cagaaggcgt gacacccgag ccgccgcttc cattataaaa ctgcggcact 2783341 tcgccctgca ctgctttaat cgatacagga acattatttg tgacgacagc ggttttgctg 2783401 gcaaatggaa tgatgacctt cactttaatt tcgacaaaga tgctgatatc aataagtgcg 2783461 ttatttatgc catacggctt gattttggtt ttgacatctg taaaagcgtc accgattaaa 2783521 ttgaaccgga ccgggatttt cggcccgagg tttccaagaa ggctgttgcc ggttacctgt 2783581 cccagcggaa tgttgatcat aatgttttca ctggcgccgc tgtgtccggt atgggtttcc 2783641 atctctttca aatgagcctg aagctgcttt gtcacttttg ttttcacact gtttacaacc 2783701 tgtgtattaa aatcgattgt cgttaagttt ccgttttcat cagaattcat ttgaaacata 2783761 tctttcatat tttcactgtc agacatatag tcctcaatcg aatcctggat cacctctgtc 2783821 gctatacgct tcgtttccat ctcgccgatg tccattaaaa caggtttgat cgagccattg 2783881 atcatccaaa ggctgaccgt tgttgacagg ataaaaaaga caacggacag gagcatcacg 2783941 taacggaaag gcaaaggtcc tctcttgcga aaagggccgc gatatcttgg caagaaaatc 2784001 cccccttaca tatcacaatg tatgcttgta agaggggaca tagtaatagc cggggccaat 2784061 ttattttatt tcatcatttt taaaagcgct tctctgccgc tcatgccgac tttgatgcca 2784121 agatcttccg cagcgtacgt gacggattct aaaggtgcgt ctaacagctg gtcaatggtg 2784181 cggacaccaa ctgcgcgtcc cgccacgatg ccgcgctcct ttaatttttc attcagcagc 2784241 gccacatcaa gcgcgccgca cataatgtat ccgtgatcat tggcgacggc cataaaattc 2784301 gttttgggaa gctttactgt cacagctgta aaaggctgtc cttctatcat gatcggtgtc 2784361 aggtttacca cgtcaaccac tcccttcatt catcacttta tgatgaaggg cacagcttgt 2784421 tgtgggctga ctgccttatt gtgcaagctt ccaagcaagc agatcccgca aaaattccgg 2784481 cataaaatat tctttttctg cagcgtcgcg aatcaacgga aacagtttgc cgagcgtaaa 2784541 catatcaagc accgcaacgg agtattgttt atgtttttca atatcttccc cgttcagtgt 2784601 gatccgagtg acgtgggtga tcccgtcatc gagccgtttc gtttctacct caacgccggc 2784661 atacaccatt ttccccatca cttctccgcg gaagccgagt cctttgatcc ggagctgctc 2784721 catttgttcg gaagcggcat ggacaatggt ttccttcagt tcttctcccg tcaggcggac 2784781 agccaccggg ttgatcggat gcggacagat gcggtgcaga tccagctttg tcacaggacc 2784841 tgcttttagc ggaccgagaa tgacacctga attgaccata ctgatgtccg tctcgcacca 2784901 ttcctttaag gcgtatgcca aaagcaaagg cagctctgat tcttcaaacc acttcacctc 2784961 agcatcttgt gcaagctctg caacggcatc ggacagtttc tcctcggctt cacgttcttt 2785021 ttcattgaga aacgctttag tttctgcgga ttctcctgtc cattccgcca tgttctgcac 2785081 agaagccgtt ttgctgttga tgcttcgctg tacgctgtcc accgtgattt ctacacagcc 2785141 gacataatgc ccgtatttct cggcgctggc cagcagtacc ccattaacca cttgtccatc 2785201 ttcgagcaaa tgatgggtat gtgattcgag gattacatca atctcaggca ccgcttcagc 2785261 cactgcttga tcatcaagaa tgcctaaatg tgacagcaga acgataatat cagcctgccc 2785321 tttcacttcc agaatggttt cctttatgct ttcaagggca tccgtaactg tccatcccag 2785381 cttgtcatat acaggataat acggcacagt tacacctaag aaagcaatgg acataccgtt 2785441 tttcaatgat ttgatatggt aaggcaccgc ccaggacgga cggtttccat ttttatcaaa 2785501 caggttagag acgatgacag gaaattcagc atgatcatat aaggcagcaa gctcttcatg 2785561 cggaagcgta atcccttcgt tattgccgat cgccgctcca tcaatgtgaa ggcggtttaa 2785621 gagatcgaca ttcgcttttc cgaatgtcgc ctctgtcacg aattgaaaac gatcaagatg 2785681 atcgccaata tcaaaaacga gcgtctcttc gccgtctgac tgatgctctt ttcttttctg 2785741 ctcgatataa tctacaattt tcggccagtt ttcaaaatgg ctgtgcaaat catttgtatg 2785801 atataagcgg agcttctcct tcataatatc tctccctaat cgttcagctg aaaatgcctt 2785861 cataaatgag ctggcagccg atcaaaatca atacgatccg catgatcata acgatcgttt 2785921 tcgtctgcat ttttctgttg atggcggcgc caagctttcc gccgaaccaa gcgccgggca 2785981 caagcgcgag ggcgtacagc caattgacgt gcccggaaat catatgtgaa acagaccctg 2786041 tcatagaaga caggaaaata ataaacatgg acgttgccac cgcaaccttc ggcggaaaca 2786101 gaaataacag catcatcgcc ggaaccatca gtgatccgcc gcctataccg aaaagtccgc 2786161 ctaaaaaacc gacaacaaag gcaatggcaa taccgacaga ggcctgatat gagtacgtat 2786221 aaggctcacc ggcatcatcc tgaaatgtcc ggataattcc tttgtgcgct ttgttgattg 2786281 gccgggcttt cgctttcagc attaaggata atgaaatcag aatcataaaa atgccaaacc 2786341 aaacggaaaa cgagtttgaa ttgaacagct ttgacacgta agccccgatc atgctgccgg 2786401 gacccgaacc gataaagaaa atgagtccgc tcttataatc aactgtttta tatttaatat 2786461 aagccaaagt tgaagaaagg cccgtaaaaa taatgaccaa aagcgaagtt ccaatcgcaa 2786521 cctgcggcgt cacatcctga aacagctgcg tcactgtgct taaaaacatc agagatggca 2786581 caatgacaat tccgccgcca agcccgatca gacttcctac cgtacctgcg attaatccca 2786641 gtacgaccaa aatcacaaac gacatcaatc aaaacctctt ttctaaaata aatcgagctg 2786701 tctcggagca agtccgctgt actcgatatc aagcagttca agcatctgct tgccattatc 2786761 cgcagcgtca ccgccggaat tgttgttgaa caggacaaaa acatccttac attgctgctg 2786821 caattcattc aggtgctttt tccaatcctc cagctcctgt tggttgtagc ggtataagta 2786881 cctgacctcc cgccagtttt tcccgccatc aggcttcatc cagccctgct tgttgcgtcc 2786941 gtgaaacctg acgagcgttt tgttttcatc ggtcgcgcgc aacacggtcg gaacgctgcc 2787001 ttctccgatt tgcggttcat cacagacact gtgaatccag ccttccgctt tcataaatga 2787061 aagcgtctgc tcataaaatg gcggcgagaa ccaggaacgg tttctgaatt caagcgcgca 2787121 aggaatatct cccatttggt gcttacacca tctcaaatag gcgacattct ccttcttgca 2787181 gtcaaaccac ggcggaaatt gaaacagcac catggcgagc ttattgctat gtaaatatgg 2787241 cgttaaagac accttaaacg catcaaacat ctcctctttt gagtcaaagg gaatttcgcc 2787301 gcgctgatgc cctgtcatgc cctgatatgc tttcacgata aattggaagg tttcgggcgt 2787361 ttccttcacc cacttttcat tattgcgcgc cggctgaatc gcgtaaaagc tcgcgtctaa 2787421 ttccacgatc ggaaaatggg aggaataggc ctgcaatttt ttctggctgg ccgttttcgg 2787481 cggatagatg ctgtcatgat ccccccatcc cgtcagtccg atataaatca cactcattca 2787541 cctctcttcc agtttatcac acgtgttttc aggtttcctc ggaaatgctg ttcatatggc 2787601 gggaaaatgc ctcacgcaaa tgctgatatt gttcctcatt cgtatctaaa aacgcctctt 2787661 ctcttgagga aggaatgtgc tgatattcaa taggcgcctg aaactgctca ctcgtaaaat 2787721 cgtacaccac accattgatg ctgttataaa aatgccagct ctcatcgact cttgttttga 2787781 aaatcgtgcc gccgaaatgg tcttgaatca ccaatgccgt cacgccgcat tggccgcatg 2787841 acgggcattc ttccgtccat ttagagctcg aatggcgcga ccaggattgc ttaagtatgt 2787901 atttgacatg ctccattgcc tccgcctcct ttaaaaaaag ataccacgtt gatgagattt 2787961 taaaaactag aacggaggaa atcaaaaaac ccggcggtaa aatccgccgg gcttacgaag 2788021 gaacgaccag agctccgtca atttcagtga ctttttcccc atcattgtac acgcaccggc 2788081 ctttgctgta agtggccgaa atgctgcagg gaaatgtatg tccttcgtaa atgctttttt 2788141 tatgctttgc aaacatcgat tctcttgtaa cagtgtacgg ctccatgctg acgagcacga 2788201 aatctgcatc acaccccgcc tcaagccgcc cttttttctg aaggccgaat cgttttgcag 2788261 gggccgccgc tgtccattct gcgatggttt caaatggaat ctgatgctca agcgccagtt 2788321 ccagcattcc taataaagtg aactgcccgc cgctgattcc gccccatgat aaaaacatgt 2788381 tatcctcccg cttcaaggat ggacggcaag gggaatggtc tgaggaaacc atgtcaatgt 2788441 ccccggcaat gagcgtctcg atcagcgtct cttttgattg ccgtgaccgg agcggaggcg 2788501 cgcattttgc gacagagccc ctttgccgta aatcgtcatg gctgaacaag acataatgcg 2788561 gacatgtttc aaccgaaaca tcaagacctt cctgtttcgc ctctctgatc agccggaccg 2788621 ctttcgccgt gctgatatgg acaaaatgaa ccggacagcc tgtcaccttc gcatactgaa 2788681 tcgtgcgata caccgcttca acttctgctt cctccgggcg ggaggcggcg tacgcatccg 2788741 catccacctt tcctttattg gccaaaacca tctgcaagta gcttgtgatc gcgtcgcttt 2788801 ccgcgtggag agcgaggatt tttcctgcag ccgcgatttc tgccatgcct ttgagcaatg 2788861 tccgttcatc aacagagcgg aactcatcag tgcctgactt tgataaaaac gctttaaacc 2788921 cgatcgctcc cgcttcagcc atcggacgga tgtcctcgat atggcctggc acaaggccgc 2788981 cccatagcgc aaaatccacg gcagattttt gcctgcctag ctcagctttt gcgagaagat 2789041 gctctgccgt cacggttgat ggaatacagt tgagcggcat atcaaaatag gtagtgcaac 2789101 cgcctgcggc catcatttga gaacctgttt caaacccctc ccaatcctcc ctgcccggtt 2789161 cattaaaatg aacatggcaa tctatcacac caggaaacac gtatttcccg tctgcctgga 2789221 tgatttccgt cccgcttgct tcaatgtcag aacctatctc ggcaatgaca ccgttttgaa 2789281 ctacaatatc agcttctata acgccatctg gcgtaactgc cttcgcacct tttatcacca 2789341 tatcgtaagc catattgatc cccccatgtc aggatgacga ttttccatgt cagtttatgt 2789401 aacacaacca gttctatttt caacagttta ctgctactat gatcgtatta catcagcaaa 2789461 accgctagaa ttcctattga aaattattca ccttaaccaa tgtttttata gaaaaggaga 2789521 atgcgctatg aatattcttg atgtgatgaa aataccggct tttgaaaacg ccaatttaat 2789581 cgctggaaaa gcaggagggg aaagagaggt tcagcatgtc aatatgatgg acgctccgga 2789641 tatcgtagac tttttgcata agaatgaatt gctcgtcacc accgcctatc acctgaagga 2789701 tcacccgcat caattatctg aactgattcg gcaaatggca aaacgcggct gcgcgggcct 2789761 cggcattaaa acaaagcgct atctggaaga tatcccgaag gaaatcatcg aactggccga 2789821 ttcatatgcg tttccgatca ttgagcttcc ggaacacatc cgactcggcg atattgtgaa 2789881 tgccacactc agccatattc tcgatatgcg ttctaacgag ctgcagcaag ccatttacgc 2789941 gcacaaaaaa ttcacaaacc acattatgag cggcaagggg ctgcaatccc tcctcaaaaa 2790001 ggtgtcagac atccttcagc ttcccgtgct gctgcttgac cagcatgcca aaatgctgtc 2790061 tgcgtctcat cagatttcag ttgagaccga aaagctgaaa ggcaccctga ataccgtatc 2790121 cgggccattt ttcacttgtt tctctacaat ctcagatcag aaaacatatt ctgtcctgcc 2790181 tatttataat cacgaaaaaa actgcggcta cctgctgata cccgacatgg tgcaggcagg 2790241 cgacaaagga ttgatcctca cgattgaaca agcggccaac gtcatttcct ttgaactgct 2790301 gaaggaaaat gcgctgaagc agttcagccg gcgggcccgc aatgagtttt tcaacaattt 2790361 tattgagcgg accttttctt cagatgacga aatcaaaaac cgggcgaaag aattcaagct 2790421 gcgctgggat caaaaataca tgtgcatcgc cggcaaactc gatcgcaatg acgaatcaat 2790481 cagctttaca gaaaatcagc tcgcttccga cagcgtattc gaatttcttg aaggtgaatt 2790541 atcagccttc ccgtttccac ctcacttctt tatgaaagga aatgtcggca ttattctaat 2790601 cgaggcgaca gacagctgga gtgaaatgca cgcctcggtg atcagctttt tagaacagtt 2790661 tcaaacacag gtcagcgctc aatttaaacg aaccgtgtcc tttggcatca gcaatatctg 2790721 ccaaaagctc attgatgttc ccgacgcttt cacagaagct tctgatgctc tgcaatcggg 2790781 gcatttgtca agaagcaccg catttatcca ggtgtatcac gccaaagatg tgcctgagct 2790841 tctgcgcttg ctcccagttg aggatttgaa gaaattttac aactccacgc ttcagagcct 2790901 cgctgaaaaa cagcaggagg atcaaagcct gcttcatacg ctttccgtct atttagagac 2790961 acactgccaa atttcagaga cggcaaagcg tctgtacgtt catcgcaata cggtcatata 2791021 ccgccttgaa aaatgcgaag agcttctggg gaaaagctta aaagatcctg aaacaacgat 2791081 gcgtttgcgg cttgcattac gtatgcagcg gctgatcagc taaagtttgt tacattttct 2791141 tacaaaacga atcgtttttc gtcactttca gcaatcacac ctgtcttttt cagctactgt 2791201 atccaatgac acccctcgac cggaacgata ttatgttact aaagttcaca tacagggagg 2791261 gactatagtg aaaaaaagat cgtttaaggt gtttacactt agcctgcagc atgtgctcgc 2791321 catgtatgca ggtgcgattt tggtgcccct gcttgtcggc agggcgctga atgtaacaac 2791381 tgaacagctg tcctacctat tggcgattga cctgttaaca tgcggcgtcg ctacgctttt 2791441 gcaaaccttg cgcggaacat acatcggcat cgggcttccc gtcatgcttg gcagttcatt 2791501 tgtggccgtc accccaatga ttgcaatcgg cagcaattac ggcattcacg cgatttatgg 2791561 ttccatcatt gcggccggtg tgttcatctt tttgtttgcg cgttttttcg gcaagctgac 2791621 tgtgttattt cctcctgtcg taacaggtac cgttgtgacc ttgatcggcc tttcacttgt 2791681 tccgacaggt gtgaaaaata tggctggcgg cgaaaaaata aacggcagcg ccaaccccga 2791741 atacggttcg ctcgaaaacc ttcttctctc tgtcggtgtc cttgttctga tcttagtcct 2791801 caaccgcttt ctcaaaggat ttgcccgaac actgtccgtt ctgatcggca tcgccgccgg 2791861 aacagcggca gcagcgatca tgggcaaagt cagcttttct tctgttacag aagcaccgtt 2791921 cttccaaatc ccgaagcctt tttacttcgg agcccctgcg tttgaaatcg gtccgatctt 2791981 aacgatgctg atcgtcggaa tcgtcattat tgtggaatca accggcgttt tttacgcaat 2792041 cggaaagata tgcggcagac ctttaactga caaagatctc gtcaaaggct atcgagcgga 2792101 aggaatcgcc attctcatcg gcgggctgtt caatgccttt ccttataata cctttgcgca 2792161 aaacgccggc ttattgcagc tgaccaaagt gaaaacaaga aacatcgtcg ttaccgcagg 2792221 ctgtatcctt gtctgtctcg gactgattcc gaagattgcc gcccttgcat ctgccgttcc 2792281 tgctgctgta cttggcggcg cgaccgtcgt catgttcggc atggtgattg cctccggcgt 2792341 caaaatgctc agcacagcgg atctcaaaaa tcaataccac ctcctgacca tcgcatgctc 2792401 aatcgcactc ggcatcggcg ccagcacggc ccccgggatt tttgctgaat tccccgctcc 2792461 gatccggatt ctggtcagtg acggcaccat caccggaagc ctaaccgcca tctttttgaa 2792521 tctatttttc agcttgcgcg acaaaaaaga attaacagca cagcaaacag aacttccggt 2792581 attagaacat acactcgcat tagaaaaaga ggtgtaaaaa agatgaagga acagcacaat 2792641 gccttacagc taatgatgct ggggcttcag cacatgcttg ccatgtatgc gggagccatt 2792701 ctcgttccgt tgatcgtcgg agcagcgatc gggctgaatg cggggcagct gacgtattta 2792761 atcgcgattg atttgtttat gtgcggggcg gcaactcttt tgcagctctg gagaaaccga 2792821 tatttcggca tcggccttcc cgttgtgctc ggatgcacgt ttaccgcagt cggcccgatg 2792881 atttccatcg gaagcactta cggtgtccca gcgatatatg gtgccattat cgccgcagga 2792941 ctgattgtcg tcttagccgc gggcttcttc gggaagcttg tccgtttttt tccgcctgtc 2793001 gtaaccggat cagtcgtcat gatcatcggc atcagcctga ttccaacggc aatgaataac 2793061 ctggccggag gtgaaggaag caaagaattc ggctcactcg acaacgtgct cctcgggttt 2793121 ggcgtcacag cttttatctt attgctgttt tatttcttta aaggctttat ccgctccata 2793181 gcgattttac tcggtcttat cgcaggaaca gcggctgcat atttcatggg aaaggtcgat 2793241 ttttctgagg ttttggaggc gtcttggctt catgttccgt ctctgtttta tttcggaccg 2793301 ccaacctttg agctgccggc tgttgtcacg atgcttctcg ttgcaattgt cagcctcgtt 2793361 gaatcgacag gcgtttattt tgccctcgct gatatcacaa accgcaggct gtcggagaag 2793421 gatctggaaa aaggctaccg ggcagaaggc cttgcgattt tgctgggcgg cttatttaac 2793481 gcgtttccct atacagcttt ctcgcagaat gtcggcatcg ttcagctctc aaagatgaaa 2793541 agtgtcaacg tcatcgccat cacaggaatc atactggtcg cgatcgggct ggttccaaaa 2793601 gcagcggccc tgacaacagt gatccccacc ccagttctcg gcggcgcaat gatcgtcatg 2793661 ttcggcatgg tcatttctta cgggatcaaa atgctatcca gcgttgacct tgattcgcaa 2793721 ggcaacctgc tgattatcgc ctcttccgtc agcttggggc ttggcgctac aacagttccc 2793781 gcgttgtttt catctctttc gggcgcggcc tctgtcttgg caggaagcgg aattgtgatc 2793841 ggcagtttga cggccattgc actgcacgct ttttttcaaa ccaaacagcc gaatagcgca 2793901 gacataaaaa cgtaaaggaa gatgccaatg ttcacaatgg atgacctgaa ccaaatggac 2793961 acacaaacac tgacagacac acttggctct atttttgaac actcttcatg gattgcggag 2794021 agatccgcag cactacggcc gttttcgtcc ctttctgatc ttcaccgcaa aatgactggc 2794081 attgtaaaag ctgcggatcg cgagacacag cttgatttaa tcaaaaagca tccccggctc 2794141 ggaacaaaga aaacaatgag cgatgactcg gtacgagagc agcagaacgc agggctcggc 2794201 aaattagaac agcaggaata cgaggagttt ctcatgctga atgaacacta ttatgatcgc 2794261 ttcggctttc cttttatttt agcggtgaag ggaaagacga aacaggacat tcaccaagcc 2794321 ctgctggcaa ggcttgagag cgaacgagaa acggagttcc agcaggccct tatagaaatt 2794381 taccgaatcg cccgctttcg tctggctgac atcatcactg aaaaaggaga gacgcaaatg 2794441 aaaagaacca tgtcttatgg caaaggaaat gtatttgcat accgaacgta tttaaaaccg 2794501 ctcactggag tgaagcaaat cccggaatca tcttttgccg gaagagataa taccgttgtc 2794561 ggcgttgatg tgacatgcga aattggcgga gaagccttcc tgccatcatt tacagacgga 2794621 gacaacactc tcgtcgtggc aacggattca atgaaaaact ttatccagcg ccatctcgca 2794681 tcctatgaag gaacgacaac cgaggggttc ctacactatg tagctcaccg atttttagat 2794741 acctattctc atatggacac gatcactctg actggcgaag acattccgtt tgaagcaatg 2794801 cctgcatacg aggagaaaga gctcagcaca agccgcctcg tcttcagaag atcgcgtaat 2794861 gaacgaagcc gctctgtgct gaaagcagaa cgaagcggga ataccataac gattacagag 2794921 caatacagcg aaatcatgga tcttcagctc gtcaaggtga gcggcaactc cttcgtcggc 2794981 ttcatccggg acgaatatac gactctcccg gaagacggca accgcccgct gtttgtctat 2795041 ttaaacatca gctggcaata tgaaaataca aatgactcat acgcttctga tccagcacgc 2795101 tacgttgcgg ctgaacaagt ccgcgactta gcgagcaccg tttttcacga gctcgaaacc 2795161 ccttcaatcc aaaacctaat ctatcatatc ggctgcagaa tattagcgag gttcccgcag 2795221 ctcactgatg tcagcttcca atctcaaaat cacacgtggg atacggttgt cgaagaaatc 2795281 ccgggctcaa aaggaaaagt ctacaccgaa ccgcgcccgc catacggttt ccaacatttt 2795341 accgtgacaa gagaagacgc cgagaaagaa aaacagaaag ccgctgaaaa atgtcggagc 2795401 ctgaaagcct gatgggaaaa ctgacaaccc atattttaga tttaacctgc ggcaaaccag 2795461 cggcgaacgt aaaaattgga ttgaagcggc tgggcgaaag tattatgaaa gaggtataca 2795521 ctaacaatga cggcagggtc gatgtccctc tgctggctgg tgaagagctg atgtcaggag 2795581 agtatgtgat ggaatttcat gcaggagact attttgcgag taaaaacatg aacgcagccg 2795641 atcagccgtt tttaaccatc gtcaccgtcc gttttcagct agcagatcca gatgcacatt 2795701 atcatatccc gctcttgctg tcgccgtttg gttatcaggt gtataggggg agttaagaag 2795761 gaagcccgcc tcaccggcgg gcttcttttt gcacttcaat taacttttga tcctaggaca 2795821 gtacttgaag tgatccccac acttagtgaa acaacagcta gaataaacat tcacctatat 2795881 ttttcaggat aattgcctac gagaaaaata ccctgtagtc ctttcattta taaatcgagg 2795941 tttcaaacta ataagtcagc tcttagcagc cgagctccct tctccaatcc tataaacaga 2796001 ccgcgttttt tctcgaaaaa atactctgaa gacaattgct gcgtttttaa tagttttgat 2796061 aacgcgttct ctcttacacc tttagacaaa atattcattt tttctttttt agacttaaat 2796121 ctatgtcgaa aataatcgtt ggcatatctt atcctatctc cactaaagga ggtgacatta 2796181 tgggattcta caattctggt ggatacagtg gaaactctgg ttactcaaac ggtttcggga 2796241 gctccttcgc tttgatcgtg gtgctattca ttttgttgat cattgttgga gcagctatct 2796301 ttaattatta agtttaactt tccttgcctc cgccgtatcc aacacctccc tgtccgacag 2796361 acgccataag aagtttttat ggcgtctttg ctatgtgttc actaatcttt ttgtaatcca 2796421 gaagctgtca agttctacga gatttatcgt gtgttttccc acaacgcttc tgcgtcttga 2796481 tcgcgctgtc tgactgaggc taaaaaagtc cggcttttaa aagccggact cccgtctacc 2796541 cccgttcaac tctcttctaa tcctgcaagc tgaccgcata atcccgccat acccggtaca 2796601 ccggcacaaa ttccccgcca gcccttcttc tatatctttg tcagaaggtt gaggggtttc 2796661 ccgaaacaat gctttaagcg caatgatcat tcccggcgta cagtagccgc attggaagcc 2796721 gccttcttcc aggaaagcgg tttgacacat atccagctct tctttttgaa gcccctcgat 2796781 ggttgtgatg gaatggccgt ctgcttgata ggccatcgtc atgcacgcat tggccagttt 2796841 tccgtcgatt aaaatagagc aggctccgca gcggccgatt ccgcaggaca cctttgtccc 2796901 ggtcagctga aattcctttc taagcaggtc actcagatgt gtcgtaggaa cggcagcaac 2796961 ctcccacgcc tgaccattca cggtcatccg gaactgttcc ttttttacag gaaatggccc 2797021 ggcctctttt atgtccattg cttcagcccc tttctgtcga tcgcttcaag caactcttct 2797081 cttgaaattg gcagcttgtt tatccagcat ccgaccgcat catgtactgc ctttacaatc 2797141 gccggagtga tggcgattgt tccgatttca ccaacaccgc gcggtccata tacgtctccc 2797201 ttcattaagt cttctattgc aatcagcttc atgtcaggaa catctttgat tccgggaatc 2797261 aaatagtgat cgagattttc cgcagcataa cggccatccg tcattttcgc ttcctccatc 2797321 agtgtgtagc cgagtgccat ggcagcgccg ccttcaattt gacctcgata tccctgcgga 2797381 ctgacaaccg gacctgccgc aatagcgtgc tcacaatcta tcaatttgac atcgcctgtt 2797441 aacagatcta cctccacctc aacggcagcc gctccaaatg agtagaggaa atggccgccc 2797501 accacaggat caggcgttgt tggaaagtca aaggccgttt cctctgccaa agggcctttt 2797561 tcagccagct ccttatacgt caccacgagc gcctttgtgt ttttgtcacg caagcctgca 2797621 gcgccgggaa taagattttc cgctgaacag ccgctccatt ctgccgcccg ttttttcaac 2797681 tgagctagaa acggcttctt caaacgctgg atcgcgtgcc acaccatgct tgtgccgcgg 2797741 gatgctgtgg aggagcctga cttcggcact tttgcggtat ccccaataac aatggaaata 2797801 tcctctgcgg cacaacccag ctcctccatg acaatctgtt caatcgctgc tagaatcccc 2797861 tgtccgcatt cttcaaatcc aaacgaagca gtgattttgc cttcactcga aagagacaaa 2797921 cggcctcctg ccgcatccat tcggccaaac cccagcccgc cgccgtgcat tgtaattgcc 2797981 gctcccgtgc ctctttgcag atacccgcag ttccggcttg tttttttaag aatgggagat 2798041 ttagatatgg cattcaacac ctgtgccgct ccgtcagttg gtgcaattcg atgctcaagc 2798101 ggccccaagt catgcggttt tctgatattt tttcttctca gctcgagcgg gtcgatgcca 2798161 agcatgccgc tgagacgatc gagatgggtt tcgagtgcaa atgtgatttg gttgccgcca 2798221 aagccccgaa attcccccgc caccccgttg ttcgtaaata ctgatattcc ttcagtccgg 2798281 atattcggaa tacggtacgg ccccgcggca tgctcgacag aaaaatcaag aacagccggt 2798341 ccgagcgtag cgtaagcgcc tgtgtccgcc acaattttca cgtcgtgcgc caatagattt 2798401 cccgaatgat ctgcacccgt ttttatcgta atcttcatcg gatggcgctt aatgccagaa 2798461 cgtacagatt cctttcgtgt ctgatgaatt ttgacagggc gtccgctttt cagggccaaa 2798521 agcgcagcat acggctgaat attcagctca tccttccctc cgaacgagcc gcccatcgga 2798581 cttgacacaa ttctgatctt ctcttcagga atatcaaaaa tacgggcaag ctggaaacgg 2798641 tctttatagc cgtgctgggt tcctgcatac atcgtaaaac ccccgtcgtc ttccggaacg 2798701 gctacacctc cctccgtttc catatacgta tgcatctgcc gcggcagctc ataggtttct 2798761 tcaaagactg tgtcagatgc ttgaaaccct tcttccacat caccgtttga aaaaaatgcg 2798821 cggtgcagga tattcccgtc ctcatgcagt ctttgcgcat tcggccgaag cgctttttct 2798881 ggtgaatcca tgacttccag ctctttatac tcaacttgaa tcagctccag cgccgcttcc 2798941 gcgatttctt ccgtttccgc agcaactgcg gcgatcgcat ccccgacata ccgcaccctg 2799001 tcctcacata aaaccggctg atcagggatg acaatgccaa atcggtttaa gccgggaacg 2799061 tctttatgtg tgacgacggc ctgcacgcct tccattttct cagcttttat ggtgcaaacc 2799121 gacacaatct ctgcatgagg ataagcactt ctcagcacct tgccatacag cattcctgga 2799181 aagctgagat cggtcatata tttcaattcc cctgtgacct taccccttcc atccggcctg 2799241 actcttgacg gtttgttgat gatcatttat tcccctccct cagccatcag ctctgccatg 2799301 atgacgttgg cagcggcttt ttttctgtat gccgctgaca taaaaacatc tgaggaaaac 2799361 ggcagctcat ggataagtgt tttgtacagc tcatgcgggt cccaccctgg tgccatccat 2799421 ttcgcttcgc tgtccaataa tctcctagga gtgatatcgg catggccagc ggcgaggcga 2799481 atgctgccgt ctttcaaaaa acgtccagct gcaacagcag ccgctccggt aaaagcctgg 2799541 cgccttccaa gcttgtgata aaatacacgc tctccctccg cccgcgggat gatgacacgc 2799601 gtgacgatag ccgttctaaa gtcttcctca ctgagccaag cgccaagcgg cagcctgatt 2799661 agctcctttt gatatacgat aagctcagca ccaagcacaa gcagaagcgg aatgaaatca 2799721 ccgattttac tcgctatgtt gccgccaatc gtggcacggc tgcgaatccc cggtgcagcg 2799781 acagcggaag cagcgtcact gaaacagcta agcgctctct taatcaaagg gttctttctg 2799841 cattcattca gtgatgtgag ccccccgatc gacacgtggg tgtcactggt gctgatccct 2799901 cgcatttcgt caatcccttc aaggctgaca aggtgctgtt tcggtagagt tcctttgtcc 2799961 cactgaagct gaaggagcgt gcttcccgat gcggcacaca catccggagc aagcttctct 2800021 aaaagcgaat aggcctcatc aagcgctgcc ggtctccata attgaatatt catccttgct 2800081 tttgtcactt ggccgttcaa gacatcgccc tccttaccat gtcatattcc tcgggtgtat 2800141 caatatcgtc caactcaccg ctatcctttg cctccaaaac cgctcctgct ccaagctgtc 2800201 cgcttttcag gagcctgcga gccccttcat ctccctttaa tccctttaca taaggaaaac 2800261 atgtcgacga gaagtagatt ggcggggtga acgcccctaa aaacgatgac acggcaaatg 2800321 actcaggagc cagagccaca agggcattga gatgatcgac ggaaagctga ggctggtcgg 2800381 ctaacaaaat gacaatgccg tccgccccca tgctttctgc ttttctcacc ccgctgctga 2800441 ctgaatgccc ctgacccttt tctgcgtctt ggcaaacgtg caggctccag cgtttttgaa 2800501 aaggcggagc gtgatacggc gctcctatcc actcaaggga ggcatgttct gtccgctcga 2800561 cgaccagcac gtgatcaagg cgggacgaca gagcagtttt caaggaaagt gagcctatgt 2800621 tttctccttt tagcggcaaa gccagcttgt tttgtcccat tcttctgctt ttgccggcag 2800681 cgagaaacac gccgatcaga taggggcttc tcatacaacc gccacccgtt ttcttgtttg 2800741 aatgatttct gcaactacac ttaccgcaat ttcctcggga ccttccgcac cgattttcag 2800801 cccgaccgga ctgtaaaagt gagacggagg atgttttccg ctcagcagcc gtttcgtgcg 2800861 gtttgccgaa cccaacagtc caatataatg gaggttttga gaaaataaga agttgatgat 2800921 cgtttgatcg tgctgataat gatgggttgc cacaacagct gcatcatgcg gaaaaaattg 2800981 aaattcgcta agcatttgtt ccggaaaagc ggtgatcagc tgatccgctt ttggaaaaag 2801041 agaggatgta caataagcgg gccgccaatc cgtcacgata acagaaaacc ctgtgtcagc 2801101 cgccaaattg gccagcggta cattatccgg tcccgcccca aacagaatga gacgcggctt 2801161 cggttcaatt cgctgaataa acatgttagt ggtttgatcg aaatgcggta aatgaagcgt 2801221 tgaaacagta cgttgaatat cttgcagagg cgcgtccggc cagttcccaa aatgtccgtt 2801281 ctccgtcaga aataaataat gggaggattc aatctttata acggaagtga cagctttgcc 2801341 tgaatgaagg cagtccctca ctttctcata gtgccgcctt ttttcctgag tgattcgctc 2801401 tgcatgaaca tgaataatgc cattgcaccc ggctcccatg ccccaagaaa gatcgtcctc 2801461 cgaccgcatg tcgtagggaa tcagcgttga tgtgagctga tcgcccagcg cactgattct 2801521 ttggaataca tcttcttcca cacacccgcc gctcagcaag ccaatccgtc tgcctttttt 2801581 cttaaagagc atagaggcgc ctgcttttcg atacgcggag ccttcaactt gaacaattgt 2801641 cgccagtaca gcctcctcct ggtcttccag gagcgcatct aacatcgtgt gaaaattccc 2801701 caatgccgca tcctcctctc gaaaattgcc gtgagaaaca actagttcag cgtgatttta 2801761 taggtaactt gtataaagaa tagacgatgg aagaaaaaat gactcatgat ttgtcagaaa 2801821 atgaaacaca tagaaagagg atttgtaaaa agagtcaaac gaagaaaatc agattggaga 2801881 aaacacgaaa tcatatcgtt aaaaagcttg cggagttccg caagcttttc tttacaccgc 2801941 tgcctggcgg ccagcgtttt catacacatc cagcgctgct tggagcgctt ttcctgcttc 2802001 gattcctgcg ttatgtctga gaagcacagc ctctaacccg gcaagcacga atagcacgtt 2802061 ttcttttctg cagctgtacc ccatcgtgcc gatcctccag atcttccctg caagcgggcc 2802121 gaatgagctg gcgatttcaa tgccgaattg tgccagcagc atgtcacgga cagactcgcc 2802181 gtcaatgccg ccgggaattt cgacacaggt gacaacaggc attttgcagc tgtcatctcc 2802241 aaacaatctt agccccattg cctttatccc tgctgctaat gcggcttcat ggtgccgatg 2802301 ccgctcgaaa cgcgtctcaa gaccttcttc aagcaccagt ctgactccct cacgtaaggc 2802361 gtacagcatc gtcgtcgctt ctgtatgatg attgagccgt ctttcgctcc aataatcctc 2802421 aagctggctc aaatcaaagt agttgcttgt aattggccga tttcccgaaa gtgctgccct 2802481 gtcagcttgt gtcgcaatcc cgcgttccac ctttttgcga gctgcaatca cgtccgccac 2802541 ccgctcatta tatgtaatcg gcgccattcc tgaaggcaca gacaaacatt tttgcgttcc 2802601 gccgatggca gcgtcaatct tccattcatc gactttaacc tcgcagcccc caatcgttgc 2802661 gactgcatcg acgataaaca atgcatcctc ggtgcggcag gcttcgccga tggctttcag 2802721 cgggtgaatc cgtcctgtcg atgtttctcc atgcaccatg gccacaattt tcggcttcac 2802781 tttttttatc tcccgtatga tgtcctccgg gtcaaaaacc gttccccatt cgcactccag 2802841 catatgaaca tttgccccat atcgctcggc gatttcagtc agcaaataac cgaaacggcc 2802901 gtaaatggga atgagcacat catcttccgg ctctatcaca ctagccagca ctgcttcaat 2802961 tcccgcccgt gaagtgccgt caatcgggta tgcccagcgg ttttttgttt ggaacagctc 2803021 ccgaagcatc tccatcgttt cattcataat acctgtaaac gccggatcaa attggccgac 2803081 aaccggggtg ctcattactc ttaatacacg cggatcaacc tcaacaggcc ccggtgtcat 2803141 aatcgttctt aacggggtgc ataattctct tctgcctgac acagccattc ctcctttatc 2803201 agtaagccag tttgtataat aaatcagtca gtgcgcggac gccgatctca agctgtctgg 2803261 ctgacgtata ttccttcggt gagtggctga cgccgcctcg gctcggcaca aacagcatac 2803321 aagcaggata gcgccttccg atcatttgcg cgtcatgccc tgctccgctc accatttcct 2803381 cacagctgaa gccgttttct aatgctgttt caaaagccgc agccttcagc ctttcgtcca 2803441 tcggcacagg ctctatccgc atatattcat caatcacagc gcgaattcct ttttgtaggc 2803501 aaatgccgtt gatcaaagca accatgtctt gatgaaactg ttccagcaca tgctgatgct 2803561 gatggcgaat atcgattgaa aactggacgc ggcccggtat gacattggct acattgggct 2803621 ctgccgttat ttttccgcat gtcagacgga gctcatccgg cagctcatcc gaccgcagca 2803681 gcagctcatg aatgatacgg ctgctggctg cgagcgggtc cttgcgccat ttcatggagg 2803741 tggttcctgc gtgattgcat tctccttcga gcgtgacgag atatcgtctc tgccccgcaa 2803801 tacttgtcac gatgccgaga tcccggcctg acatttccaa cgtcttcccc tgttcaatat 2803861 gcagctcaac aaacgcgctg atatctgtcc tatatgctga ctgaaacaca cctttgccaa 2803921 aaccgctctc atgcatcgct gtttggaggg agactcccga ctcgtctctt ggctcttttg 2803981 catcttgttc tgaaaaaaca cccgtcatat tccccgaccc ccaataggtc attggaaaac 2804041 ggctgccttc ctcctcacat aaggagaccg cctcgagcgt tttttttggc gctccgtatg 2804101 tttccttgag ctgctttaac gcgagcattg ccgccagaac gccataggcg ccgtcgtatt 2804161 ttcctccatt gatgacagta tcgatatgtg aaccggttac aatgacttca tccggagact 2804221 gggtgcccga aagccttcca aacacattgc cgacatcgtc gaatcttgtt tcaagcccga 2804281 aagaagacat ttccgttttc acagcaagct gtgcgtccat ccactctttt gtgtataaaa 2804341 gcctcgttac gccgccatcc gcagacgcac cgtattgggc gagccattca atataatctg 2804401 tgatgctgtt ttttactgaa agcttctgct tttccatgta ctcccccctc tggccgctat 2804461 ggtgacttca ttatagaagg agcaacatga tagttcattg acagattaac caaaaaaacg 2804521 tttatttttt agccacagta tccatccagc aaccagatac accctacatg tcacaactat 2804581 tttgatgtaa aggtcaaaag aaaacacggt aaggaagaga gccagcaaga gcgaaagaga 2804641 gggtcaaaat gcctttcata tgaacaagct aagctggaga ggcgatgttc gcggaacgga 2804701 tgaaaacaga aatgccggca gcccgcaaaa acaggaccta aagatatgga aacaggagat 2804761 ttccgcctcc tccaaaggga ctaatttaca attttaatga aaaatataca aaatgacact 2804821 tctatccttt atttcaattt tagataatag atatgatctg ataaaaggag ggcaagtgat 2804881 gacaaaaaaa gcatggtttc tgccgctcgt ctgtgtatta ctgatttccg gatggcttgc 2804941 gccagcagct tcagcaagcg cgcaaaccac attaagcctt aatgaccgat tggcgtcttc 2805001 cccttcagga acgggaagcc ttctctcatt agccgccccc gctgcaccct atgctgacac 2805061 agatacctat tatgaagggg ctgaaggtaa aacaggagac tcgctaaaaa gcaccctgca 2805121 ccgtattatc agcggacaca cgatgctgtc ctacagcgaa gtgtggaacg cgctgaaaga 2805181 aacggatgaa gacccaagaa atccgaataa cgtcatcctg ctctatacga atgaatcgcg 2805241 ttccaaaaac ctgaacggcg gcaatgtcgg cgattggaac cgcgagcatg tctgggcgaa 2805301 atcccatggc gattttggta cgagcaaggg acctggtact gatattcatc atttgcgccc 2805361 ggctgatgtt caagttaaca gcgccagagg aaatatggat tttgacaatg gcggcactga 2805421 atatgcgaag gcacccggaa attattatga cggcgattca tgggagcccc gcgatgatgt 2805481 gaaaggcgat gttgcccgca tgctgtttta catggctgtc cgttacgagg gtgatgacgg 2805541 ctatcctgat cttgagctta atgataagac aggcaacggc tcagctcctt atcatggcaa 2805601 acaatctgtc ctgctcgaat ggaataagca ggatccggtt gacgaccgcg agcggaaaag 2805661 aaatgaaatc atttatgaaa aatatcagca caaccgcaat ccatttatcg accaccctga 2805721 atgggcggat gagatttggc cgtaagaaaa aggtgctcct tttgaggagc acctttttct 2805781 aatacacagc ctcttccgtt tccgcatcga aaaagacgac gtggtccatt ttcactgaga 2805841 gctggattga atcgcctgca tcgattcgcg tgtttccgtc caggcggacc ttgagccgct 2805901 cgtccccagc catgacatgc actatgagct ccgagcccag attttcattc acttccacgt 2805961 tcgcttgaaa cactgaatca aacaactggt catttcctgt catttgtgtg atgtgctccg 2806021 gccgtacacc ggcaatcatc tgttctccgg catatccctt ttccttcagc cgctttgctt 2806081 tttcttcagg aatatgaagc cggatcgaag aatttgtgaa aaacagctcg ccatgctgct 2806141 gttctatgat gcctttcaaa aagttcattc cgggagagcc aatgaagcct gcgacaaaca 2806201 aattggccgg gtaatgataa atgtcatgag gtttcgccac ttgctgaatt tccccttcat 2806261 tcatgacgac aatccgatct cccattgtca ttgcttcggt ctggtcatgc gtgacataaa 2806321 tgatcgttgc ctctaatcgc tggtgcagct tgctgatttc tgtccgcatc gtcactctta 2806381 gttttgcatc cagattagaa agcggctcgt ccattaaaaa gaccttcggc tccctcacaa 2806441 tcgacctgcc aagcgccacc ctttgccgct gcccgccgga gagcgccttc ggttttctct 2806501 tcagcaaatg ttcaatttct aaaattctgg ctgccgcatg aacccgctcg gcaatttcct 2806561 gtttcgccat ctttctgagc tttaatccaa acgccatatt atcaaaaacc gtcatatgcg 2806621 gataaagcgc atagttctgg aataccatcg caatatcacg ttctttcggc ggaagatcat 2806681 tgacccgctc cccatcaata agaagatttc cttcagaaat gctttctaat ccagccacca 2806741 tccgcagcgt tgttgatttt ccgcatcctg acggccccac cagcaccaaa agctccttat 2806801 cctttacatc taaatcaaag tccttcacgg ttaattgtga gtgatatgat tttttgacgt 2806861 gttcaaatgt taatgaagcc atcagaaaag tccccctatc ttttgacccg ttatttcgtc 2806921 actggaaaca acttggtctt tctgttattt ttagagtaat cgattcccat ttttgctata 2806981 tttctaaaat aaaaaatgta aatttgtatt ataacgtcat aatacattat aatataaata 2807041 ataggttaaa aggaggctac cctttgttaa acaacggaag ttctacacct ttatacattc 2807101 agctaaaaca aatcatcact gatgacatca aaaagggcgt gtattcccca accgccaagc 2807161 tgcctaccga aaacgagctt tgcaccaagt ataacgtcag ccgcatcacc gtcaggaaag 2807221 ccattctcga tttagtcgaa gaaggctatc tgatcaggca gcagggaaag ggaacgttcg 2807281 ttaaaagccc taaattaaaa cgagagctga tcgctgtaaa cggctactcg gaatttatgg 2807341 aatcaaccgg caaaaaaccg aagcatcatg tgctgtccca tgacatcatt ccagcgtcaa 2807401 aacccatcgc cgaaaagctt caaatccaac ccgagagccc tgtggttgaa ttaaaacgga 2807461 ttttatataa tgatgatcag cctctcacct ttgaagtgac gcattatccg cttgatttgt 2807521 ttcccggcat tgataccttt attgctgacg gcgtctccat gcatgatatt ttgaaacagc 2807581 aatacaaagt tgtacccacg cacaatacga agctattaaa cgttgtatat gcccaacagg 2807641 aggaaagcaa atacctggat tgtgatatcg gggatgcgct gtttgaaatt gataaaacgg 2807701 cttttacatc aaacgaccag ccaatctatt gctcattgtt tttgatgcac acaaaccgtg 2807761 tcacttttac catcaacagc ccctacacat aacaggcata aaaaacgaga cactgcttat 2807821 agtattctcg ttttttcact gcttcccccg tcctccaagc gataaggata gccatagccg 2807881 aaagctccgt acacaccgca agttttcgca gccgtttcag cagcctggcg caaagcatac 2807941 gttatatcct gcttcacgca aaaggcagtc aaaaagcctg ctataaaaga atctcccgct 2808001 ccaagtgtat ctattatatc agcttccaca atcggctgat gatagactcg atcacccgca 2808061 gacaggattg ctccttggcc ccctcgggtc atacaaacca ttttggctcc gtacccatga 2808121 gctgttttgg caagctcacc gcattccgac tcactcaaat cgcttcctga aaaaaacgca 2808181 tacgtcacat aaggacagac cctcctcaaa taatcatcct cccgattggt tgaaaaatca 2808241 aatgagaccg ggaccagccc gcacagctgc ggaagatcgt tctcaagcct gctgtacacg 2808301 ctcgtatgca gcagatcatg cccgctgata aaagatacat ctttctcctg aaacgcgagg 2808361 cgaagccggg actgaatgcc gcctttattt gatctgacaa aaatgcggtc cccctgttca 2808421 tcaagggtga caatcgccat cccgttttct ccgtgcgcct ggcggatata atctgcattg 2808481 acctgctcca gcttgagaac gttcaacaga tgcgccgcgg cttcgtcatt gccgacgatt 2808541 ccgatatagg aagactcatg cccgagccgc ttggcaagca cagcaacgtt taaggcattt 2808601 cctcccgggt aaaatgtttc ttgatcctgg tagtaatcta caacattatc tccaaccgca 2808661 atcaatttca tagcgcttcc tcctttatcc ttttacactg ccgcttgcaa tcccgcggac 2808721 aaaatatttc tgcatcaata aaaatagaat aataatcggc gcggctgaaa tcgttaaccc 2808781 cgccagcagg acgccccagt ctgtctgcag cgcgtctctg aactgcatca gcccggctgg 2808841 aatggtccgt aaattctcat catctatgaa aataatcgca aacataaact cattccatgt 2808901 atggtaagcc gtcaaaatgc cggatgtcac caaaatcggc acgctcattg gtaagaaaat 2808961 tctgaaaaat actccaaaac ttgtacaccc atccaaatag gccgcctcct ccaattcttt 2809021 tgaaatagaa agaaaataag agcggatcaa aatgatggtg aatgggatcc gataagccgc 2809081 atacggcaag attaacgccc aatacgtatt gtacaggccc agcgactgaa taatagaata 2809141 aagcggcaca agactgacct gcggcgtcag catcaatccg ccaagacata gcaccaaaaa 2809201 gaatcctttt cctttaaact caaaccggga aaggccatac gctgcccatg cactgataaa 2809261 gacagtgatc acacacgtca gcgccgtaac gatgacactg ttcataaaat aagaagaaat 2809321 cccctgattc caggcggaaa caaaattttc cggatgccac gaagacggca gcgaccagct 2809381 gtgctcaaaa atatcgtcag agtttttaaa ggcgctcatc accatccaga gaagcggata 2809441 ggcaatcgca atcagataaa gaaacagaaa aacccacaca gacgtttctc cgatatacca 2809501 ttttcgtcta ggcttatctt tcacctcaat gtgctggtca ggcaccggct ccaatctgaa 2809561 cgaatctgtc ttcttctgag gcagcatcag ttactcctcc tttccggttt taaagaactt 2809621 catttgcatg agcgataatg caagcgtaat gattaacacg acagtggcaa tcgctgaggc 2809681 gtagcccatc atatcctttg taaaggcgct tttatataaa aacgtgctca agacttctga 2809741 cgcttttccc ggcccgccgc ctgtcaaaat gtacggctca ttaaagaccg taaaggctcc 2809801 ggtcagcgtc atgaccaccg caacaaaaga catctctttc gtctggggaa cagtaatatg 2809861 aaaaaactgc tgaattttac ccgcgccgtc aagccgggcc gcttcataca gttcatccgg 2809921 tattttttga atcgacacga tgtacagcat cgcaatataa ccgacagatt gccactggga 2809981 cacaaaaatg acagaaagca tagctgtgct gtcatccccg agccaggccc tcgtcagctg 2810041 atcaagaccg atggcctgaa gcagctgatt caaaagccct gtctccggat tgtaaataaa 2810101 atcaaacaaa agcgcgatca ccgtcattga gatgacaacc ggcaaaaaga aaacggtacg 2810161 aaaaaacggc gaccattttc tgaccagctt atcctcaagc accgccgcca aaatcaaacc 2810221 gccaaatacc tggcatacaa ttgagatcac tgcataaagc acattattgg taagtgcctg 2810281 atagaagaca ggatcatgaa ataattcaac atagtttttt aagccgataa acgttttttc 2810341 cggagaaaat gagctccact gaaacaggct gaggaataca ttctcaaaaa tcgggatata 2810401 aacgaaaagt aaaaaaacga gagcgggcac caaaaacaaa taggggatta ttttattctg 2810461 attgaccaag ggtatctcat ctcctttata aaaagaaaag gtgcgaagct tcaccttttc 2810521 tttgatttat tcagctgacg ccctcacctg ctttgctgcc ttttgaacgg ctttcatcac 2810581 ctgctgcggt gtcatgtcgc cgccaagcat ttgctggacg cccgttaggt acgcatctgc 2810641 gacttcaaca tcgacatcca tatcaaacca tggaaccatt gatttggcat caacaatatg 2810701 ctgaacggct tcacgctgaa tggctgttgc attttcttca gtagccgtac cttgcactgc 2810761 actgtatttc ccgacatctt tcacgagctt ttcgcccatt cttttcgacg tcaagaactg 2810821 caaaaattcc atcgcttcct tcggatgttt tgttcttgag gagatcatga atccttccgg 2810881 cgctcccgtt aacgcttctg aagatccttt ctgcccgctg atttcaggaa atgggaacat 2810941 cccgagatta accggttcaa ccagcttgat ttccgctgtt tccgcatata tcatcgccga 2811001 ctttccgctc ttaaattgct gtctcacata ttcgtggtcg acggagttta catgtttatt 2811061 aaagtaaggc atcagctctt gaagcttttc aagtgctttt acgtagcctt catcagtaaa 2811121 ttcacccgtt ttggcgttat agtccttttc ccgtgttttt tcatcgacca tccgctgatt 2811181 aagcgtgccg atatagtgcg agattgtcca agtcgccttt gttccaaagc tgatcggtgt 2811241 gtagccatgt tctttcagct tttttgacac atcgattaat tcatcccacg tcttcggggg 2811301 atcaagattc agcttttgga aaatgtcttt attatagaag aatgatttag cgtccatttg 2811361 ccacggtacg ccatattgct tgttttcata agtaaatggt gtaatttgcg attgaacgag 2811421 ctgtgatgac caatcggtgt catttttgta gtaggacgag agatcaagtg ctttattgcc 2811481 tctgataaat ttaaaagcaa actcatcgct ccaagagaag taaatgtcag gagggctggt 2811541 ggttcccagc atgaccttaa ttttatcttt ataggagtca tttaaaacgg cttcaatttg 2811601 aatgtcgata tctgggtgat ctttttcaaa ttccttaaca acctcttcaa aataactttt 2811661 ttccggctcc tttggccatc tgtggaaaaa tttcaatgtc acctttccgt ccgctgaact 2811721 gctttggctc gaacagcctg cgatggtgag catactgaca gctgcaatga tcaagaacaa 2811781 caacattttc ttcaaagggt tggcctcctc tggacattag actataatgt tatataacat 2811841 tatagtctaa tgcataatgg ttcttcattt tcagatcaat actcaacttt ccacatgtat 2811901 cttctatgag ataaaggatg atttctctcc tctgccagct cgtctgcata gcttctcagc 2811961 acacgattga gaacgagcgg agcaagatag cctttaactg aatcgtcaat tgcagtgaag 2812021 tcgtaagatg cagcatcaag cacagtgagc tttttgccat actttttcga gaaggtaagc 2812081 gcccgctctt caagaggtct tgtttcatct aaaccgagca ggatgataaa cggcacggat 2812141 tcatcaataa tttcaaacgg tccgtgaaaa tattctccgg catgaatggc gtgggaatga 2812201 atccattgca tttccatgag aatgcagatg ctgtaggagt aagcgacacc gtagtttgca 2812261 ccgcttgcca tggtataaat aatgctttct ttttcatggg cttttgcaaa ttgcttggcg 2812321 ttgtcagctt cctgcttaag ggctttttca tatacagcct gcaattgatc taagccttca 2812381 attgcttgct caaatttcgt attgttttct aatacttgca gggttccaaa aacgatttga 2812441 tacaaaacgc catagtttgt attgatcgca agcgcctcat caccccaatc gtactgggca 2812501 acatattgcg cttcctgcgc taaaggagac tccggtttaa acgtcatcgc aatcgtaagt 2812561 gcgcccttgc cccttgcaaa cgcagcagct ttgactgtct ccggggtatt tcccgaatgc 2812621 gagcacaaaa taacaagaga cttttcacca agctgaacag ggttgcgctg aataaattcg 2812681 ttggcgctgt agagatcgga gtttattgat tttgactctc tgtcaaacac atacttactc 2812741 ggatacataa tggcagaaga ccctccgcat gcgacaaaga atacatgatc aatggttttc 2812801 cctttcaaat cctgcaagaa agcttgaacc tcacgattta cttttgctgt ggcctgactc 2812861 aaatccttca ctcctcgttt ttattatata acgttatata acattatata ttgttatatt 2812921 aaagtccgcg ggtaggattg tcaatattat tttctgaaat ttctcaataa tttattcgga 2812981 tgacagacaa agggtctata tgcgaaaaaa tgcccaaatc aaaagccaga acttgactta 2813041 agctctggct tcgctgttca atccgcagac tgacgtctta tttaaaaaat accttgtcta 2813101 tattgtactt cgagtgctgt gtattgatga tatatgtttc gtaaatctct ctttccattg 2813161 gatcatcaac tacacatacc tcaattttat aaacttcatc tctgtgatgt ttgatcggtg 2813221 aaacagtgtc ttcgaaatgc ttcttaattc tctgtcttaa ctttctggct ttaccgacaa 2813281 acagcagctc gtcatgaatg ttgtaaaaca taaaaatgcc gcctttgtcc cttgggatct 2813341 ggtgaaagtc gatgaatccg tgaatcggtt ttatcttcgg ctcgttatca ttagctgact 2813401 gctgtcgttc agtgatggtg acattcggtg cgggtatatc aatttttatc aaaatcagtt 2813461 cacgtcctct ttttcattaa agataaatgc taacacatac agaaaagaaa agctagaaca 2813521 gctttattat atttgtttgt catgctctta cttattatgc aagtgctccg gctggatcat 2813581 aaggactaag gtctaattct gtctgctttc cgagaactag ctttgcgagc tctgcaccca 2813641 aaaacggccc catcgtcagt ccagaagcac ccaaaccgtt tgcagcgtac aggccttgaa 2813701 cattcggcac ggcccctacg accggcagaa atcccggtgt aaacggcctg aagcccactc 2813761 ttgtttcaac agcagccgca tcagcaagac ccggtgcaac ggctaacgct ttgctcaata 2813821 cttcgtgctg gcctccggct gtcacacgaa gatcatcaag accggcatcg ttttcgtgtg 2813881 tggcgccggc tacaattctg ccgttatcaa acgacagaat gtactgatca ctcggcggca 2813941 ttacaaccgg ccacgatcct gtatctgcat ctgtcatttc aaaatgcata atctgcgctt 2814001 tttgaaatga cacttgaaaa tgaatgccaa gaggcttcaa tatctcattg gcccatgctc 2814061 ccgccgtcac aatgaccgcg tcagccgcaa actgctttgt atctgtttgc acgccggtga 2814121 ctgttccgtt ttcaaaaagc aaggacgcat ttcctttgat gaccgttgcg ccgcgtttct 2814181 ctgcagcgct taaaagcgac cggcacagcg ctcttccgtt cacacgggcg gcaccgctga 2814241 tatgaaccga ttcatagccg tcagctaaaa tcggaaacag ctttttcgtt tcacttgcag 2814301 acaagcgggt aatgtcgccg atttccggcg catcctcccg tctcttatac gccctttcct 2814361 ccattttatc gagtttagac gcgtcagtat gaatgctgat ggcaccgaca cgtttgtatc 2814421 ctgtatccga ttcaccgtct ttttccaatt gatggattaa atccttatag taccgcgctc 2814481 cccccttagc aagctggtac caatcctgat tacggcgctg cgagagccaa ggacagacga 2814541 tccccgccgc cgcatcagtc gcttgtcccg gctctttccg atcaatgaca gtaacgcgag 2814601 cgcctgtttt tgcgagatga taagccgtcg acgcgcccag aatccctgcg ccgacgatga 2814661 tgtacgattt catatgcaaa caccttttct attataatgt ctattcattt taccaaatca 2814721 aatgctttcc ttcgaccttt tgccctaatg tggaaaaacc gcgaagttcg tccaatctct 2814781 ttactctcct atcgaatatc ctgtcactat caatagagaa aggatgatac catgagcgaa 2814841 aatcgtcatg aaaatgaaga aaacagacgc gatgcggcag tggcaaaagt ccaaaacagc 2814901 ggtaatgcaa aagtcgtggt cagcgtgaac acagatcagg atcaggcaca ggcgcagtca 2814961 caagacggag aagactaatg aacgaaaaca tcattcctct taacagacat actcaagaga 2815021 tacccactac tgaatctgtt atcaaaaaca gcggcaactc agaggtccat atcgacattc 2815081 acattgatac aatgccaatt gcttttgcta tattatgctc tgcattagcc gcaaagcaga 2815141 tgacaaaaga ggaattcgat atggcttata ctcaattgcg agagatgaac agagaaaata 2815201 acagcagatc atctgtaaag caaattatca atcaagagac agaagaagag taaaaaaccg 2815261 cggcccctcg gccagcggtt tttcttctgc atacaaaaag gacgcgactg aatcggttac 2815321 ttctgtacaa tttgaataag gttaccgcat gtatcgtcga agacagctat tgtgacttcg 2815381 cccatttttg tcggttccgt cgtaaacgtc acgccttttt cctttaatcg gttgtactct 2815441 ttttgaatat ctgcaacgcc aaacattgtg gccgggaggc cttcggagaa tatcttcttt 2815501 tgatactcct tggcggcagg atgttcattc ggttcgagta aaagctcggt tccgtcttga 2815561 tcatctggag aaacaagcgt tatccacctg aatttcccca tgggaacgtc ttcctttttt 2815621 ataaacccaa gtttttctgt ataaaactcc agtgccatgt cttgatcttg tacaaatata 2815681 ctggtaacaa cgattttcat actgtttttc cctccttcga tatgaatgaa gcatggtact 2815741 atgctaacaa tctggctaca agcaaaacaa cccacacatt tatcagaggc cctgttctga 2815801 ttttataaaa ttattctatc catcctttca gcaaattttt aagcggttcg ttgttgaata 2815861 taagtactcg atattttccc tttcgttttg atgttacgag tcctgcatcc tccagtacag 2815921 aaaggtgttt agctatcgcc tgtcgcgtaa tagaaaggtc gtactttgta ataagacgta 2815981 tcgtaagttc atacaacgtc agctcgttgc gttcagataa ttcgtctaat ataagccgcc 2816041 gagtcgaatc gccgagtgct ttgaatatag cgtctttgtt cccattcata tattgagtat 2816101 aagcaaccca ttagttgcat gtcaagtata agcaactgta tggttgcgtg atatagaaac 2816161 tgaacctatc cggcgcaggt ctgaaatatt ctaatcgata aggaattaaa accattaaaa 2816221 taacagtgga tatgtctctg aaaaataaaa gaagacgaac ttcaaaagtt cgtcttctac 2816281 aatcaaattc ggcacgccgg ccattttaaa gttgataact atctctaaac cccttgataa 2816341 acaaaggagt tttcatcatt aaccgataga accttccatt tcgaacttaa tcaaacggtt 2816401 catttcaact gcgtattcca tcggaagctc ttttgtgaat ggctcgataa agcccattac 2816461 gatcatttca gttgcttctt cttcagaaat accgcggctc atcaagtaga agagctgctc 2816521 ttcagatact ttagacactt tcgcttcgtg ctccaatgaa atgttatcat ttaagatttc 2816581 attgtaagga attgtgtcag aagttgattt gttatccata atgagcgtat cacactcgat 2816641 gttagagcgg gcgccttccg ctttgcgtcc gaagtggacg attccgcggt acgttacttt 2816701 tccgccctgt tttgaaatcg attttgatac gattgtagat gatgtgtttg gtgcaaggtg 2816761 aatcattttc gcacctgcat cctgatgctg gcctttaccc gcaagagcga tagaaagcgt 2816821 cataccgcgc gcgccttcgc cttttaggat acaagccgga tatttcattg tcagcttaga 2816881 accgatgttg ccgtcgatcc attccattgt tgcgttttct tcacagactg tacgctttgt 2816941 tacaaggttg taaacgttgt tcgcccagtt ttggatcgtt gtataacggc agtagccgcc 2817001 ttttttcacg atgatctcaa cgaccgcact gtgaagtgag tttgttgtgt aaacaggcgc 2817061 agtacagcct tcaacataat gaacgcttgc ttcttcgtca acaatgatca gtgtacgttc 2817121 gaactgaccc atgttctcag agttgatacg gaagtaagct tgtagcggtg tttcaacctt 2817181 cacgccttta ggcacgtaga tgaaagaacc gccggaccaa acagctgagt taagcgccgc 2817241 aaacttgtta tcagtcggcg ggattacttt tgcccagtgc tcacggaaaa tatcttcatt 2817301 ctctttcagc gcgctgtcag tgtctttaaa gacgatgcct tgtgcttcaa gatcttcttt 2817361 catgttgtgg tatacaacct cagattcgta ctgagcagaa acacccgcaa ggtatttttg 2817421 ttcagcttca ggaataccga gcttgtcgaa tgtttgttta atttcttcag gaacttcatc 2817481 ccaagaacgc tctgaacgct cagacggttt tacgtagtac gtaatttcgt caaagttcag 2817541 tgagtttaaa tctccgcccc attgaggcat cggcatattg tagaaatgct caagtgattt 2817601 caagcggaag tcaagcatcc attgaggctc ttctttcatg cgagaaattt cttctacgat 2817661 ttcttttgtc aatccgcgct ctgaacggaa aatggaaacg tccttgtcgt gaaaaccata 2817721 cttgtattca ccaatatcag gcattttttt agccatccat tttcactcca atccttttaa 2817781 ttgccgcctt cttctttcgc gactcctttt tcaagtgctt tccatgacag ggttgcacat 2817841 ttgatacggg cagggaattt tgaaacgcct tgaagggctt caatatcccc gagatctata 2817901 gaatcatcat actctttccc ttgcatcata tccgagaaaa tcttagacat ggaaagggca 2817961 gtttcaatat ctttcccttt aatcgcctga gtcatcatcg aagcggatgc cattgaaatg 2818021 gaacagcctt ccccttcaaa cttcgcatct tccacgatgt ctccgtcaag cttcattgtc 2818081 agtctgatgc ggtcgccgca tgtcggattg ttcatatcca cgacaatgct gtcatttaaa 2818141 acccctttat ttcgcgggtt tttgtaatga tccataatca cctgtctgta caatgtatct 2818201 aagtttgcat taaaagacat ttgtaaaata ctcctttgtc ttttgaagag cttccacaag 2818261 cttatcaatc tcttcctctg tattatacag ataaaagctt gctcttgcag tagcagttac 2818321 atccagccat ttcatcagcg gctgcgcaca atggtggccg gctctgactg cgattccctc 2818381 cgcatcaagc acagtcgcca catcgtgcgg atgaacatca tcaaggttaa atgtgacaag 2818441 cccggcacgc tcttccggcc cgtaaaccgt tacgccgtca agctggcgga agcgttcaag 2818501 cgcataagct gcaagcttgt gctcatggcg ggaaatctca tcaagaccga tttcttcgag 2818561 aaaatcaatg gcggcaccga ggccgattgc tcctgcaata atcggcgtac ccgcttcgaa 2818621 tttccacgga agctctttcc aagttgattc ataaagcccg acaaagtcga tcatttcacc 2818681 gccgaattcg gcaggctcca tgttttccag cagggctttc tttccgtaca gcacaccaac 2818741 accggtaggt ccgcacattt tatgggaaga aagcgcaaag aagtcgcaat cgagatcctg 2818801 cacgtcaatt ttcatgtgag gcgtgctttg tgcaccgtcc accacaatga cagccccatt 2818861 gtcatgagcg attttcgcca tttctttaat cgggttgacc gtgccgagaa cattagatac 2818921 atgagacacc gcaacaattt ttgtgttgct tgtgaccgtt tctctgacgt cttctaaaga 2818981 aatcgttccg tcttcctgca acggaatata ttttaatgtg gcgccagttg cttttacagc 2819041 ctgctgccac ggaatgatat tcgcatgatg ctccatgtag gtgatgacca cttcatcacc 2819101 aggtttcagg ttggcgcgcg catagcttaa cgccaccata ttcagtgatg tggtcgtgcc 2819161 ttttgtgaaa ataatctcag ccattgactt cgcgttaata aacttgcgga ctttttcacg 2819221 cgctccttca taaccatctg tcgctctggt tccaagtgta tggacgcccc ggtgaacatt 2819281 ggaattgtat tggttataat acttatccag tgtttcaatg acagcacgcg gcttctggga 2819341 agtcgccgcg ctgtcgagat aaacgagatc atgtccgttc acttgctgat gaaggatcgg 2819401 gaactgttca cgaatatctg tgatattcat tacttcactt tcctttcgat aacagaaact 2819461 aattgtttct taacgccttc aatcggaagt tcatttacta ccggtgcaag gaatccgtaa 2819521 atgactaagc gttctgcttc ttctttcgga attccgcggc tcatcaggta gtaaagctga 2819581 atagggtcca cacggccgac agatgccgca tgtcctgcag ttacatcgtc ttcgtcaatt 2819641 aaaagaatag ggtttgcgtc tccgcgtgct ttttcgctaa gcatcagcac gcgtgattct 2819701 tgctccgcat tcgctttaga agcgccatgt tcgattttgc cgattccgtt aaagatagaa 2819761 gaagcggaat ccttcatcac accgtgcttc aagatatagc cttcagaagc tttaccgaaa 2819821 tggatgattt gtgttgtgaa gttttctgtt tgctctcctc ttccgacaac aaccgttttc 2819881 gtatcgccgt atgtgccgtc accgtaaagg tttgttgtgt tttcggaaat cgtgtcgcca 2819941 tcgttcatca ggccgagagc ccactcgatt ttgctgtcgc gtccgcgcgc agcaccgcgg 2820001 cggttcacat aagttgtcac accgcttgac agattatcca ccgcaccgta tgtcacgctg 2820061 gcattatcac ctgtgatgac ctcactgata atattgaaga cagcgtcttt cgggtttaca 2820121 gtgctgatgt agttttctac atatgttaca gagctgtggt cttcagccac aatcagcacg 2820181 tggttgaata gagctgtatc attgctttcg tggacataaa cagcctgaac cggcgtctcc 2820241 acctgaacat ttttcggaac ataaaggaat gctcctccgt taacaagagc cgcgtgaagt 2820301 gcagttaact tatgttcgtc aaccttcacg ccgtccttca taaagtattt ctccaccaag 2820361 tcgctgtgct cgcgtgcagc agtcagaata tcagtgaaga tgacgccttt gtctttcaat 2820421 tcttgagaaa gagaaagatg tgccggcgtc tggtcacgct gtacgtataa tgttttatct 2820481 tcgttttcaa tgtcgatcag cgcttttact tcatcagtca aatcttctaa tgaagaaagc 2820541 ggttcgttat ccactgtatg cttcgcgaaa ttcgtgaagt tccagtttgt gatttttgtt 2820601 ttgtcaggtt tcggcatcgg cagatcctca gcttgttcaa gagcctgtaa gcgcaggttc 2820661 ttcagccagg caggttcttg gtgcttttcg gaaaagcttt tgagatactc ctgatctacg 2820721 gatagttttg tacctagtgt catattaatc cccctaacgc ttacgcttct tggccaacag 2820781 tttcgtcttc aatgccaagt tcttgtttga tccagtcata accttctgct tcaagacgct 2820841 gtgcaagctc tgcaccgccg gattttacaa cgcggccttg catcataacg tgaacaacat 2820901 ccggagtgat gtagtttaac aggcgctgat agtgagtgat catcaggcag ccgaagtttt 2820961 cgctgcgcat tttgttgatc ccttttgata caactttcaa agcgtcaata tcaaggcctg 2821021 agtcaatttc atcaaggatg gcgattttcg gttcaatcat cattaattga aggatttcgt 2821081 tgcgtttttt ctccccgcct gagaagcctt cgttaagata gcgctgagcc atttcagggt 2821141 ccatttcaag gaactccatg ttttcgtcca ttttgcggat gaatttcatg agagaaattt 2821201 catcgccttc ttctctgcgc gcgttgattg ctgagcgaag gaagtcggca tttgtcacac 2821261 cgctgatttc acttgggtac tgcattgcaa ggaataagcc tgcctgcgca cgctcgtcca 2821321 cttccatctc cagtacatct ttgccgtcaa gcgtgatgct gccttttgtt acttcatatt 2821381 taggatgccc cataatagca gctgataaag tggatttacc agttccgttc gggcccatta 2821441 ctgcgtggaa ttctccacct tttatttcaa ggtttacacc ctttaagatc tctttccctt 2821501 cgatttcaac gtgaagatct ttgatcgtta atgttgaagc agccatatct atacctccaa 2821561 aaatatataa tcattattct cattttattc tcattctaat tttataacaa atgaaaagta 2821621 aatacaactt tttatcgtgc cttgcacatt cctcaagttt aacaaagatc agcactttat 2821681 taaagcgatt gaaaaagaaa aagagtggat tcccaccctt ttttaaaaga ttgattttct 2821741 caataagctc ccgcagaaat ccgcttgctt ttttcataat caagctctct ctgccgctct 2821801 actttcattc ttgtttccag ccggcgtcca tattcctcgt atccaattcc gtgtgacagc 2821861 tgcatcgctt tttccatttc tgacgtataa tcgaggttca gtctgtcctg gctgctgcaa 2821921 ataatgaatc aatcccttca tatatttgct ttttattgta ccagtgctgc gttggatgcc 2821981 gcaaaaacga tttggcgtga aatagcggca gatgagacga aagcatcctt tcagaacaaa 2822041 tgagaatggt ttttcggaat attccttctc ttaatgcgtg gtgtttccga attcctcaat 2822101 gcactgttga acgactgtca cgccttggct gaaagctgcg ccgcctccaa atgccgctgc 2822161 cacactgacg gcttcgagaa tgttttcttc tgacgctccc tgatcaagac agccttttgt 2822221 atgatagatc atgcaatatt cgtcctgagc attgatggca attccgaggg cgatcagctg 2822281 tttttctctt tcagtcagag aattcccggc aaagcactgt tcagtaaatt cgttaaattt 2822341 tcttcccatc agcggcatct tttgttcaaa tgtgcctaaa ccatgtttat attgttttaa 2822401 cgcgtcctgc atgcttcctc tgtcttgatt caaagaaaat ccctccatct gtttaacatt 2822461 cctttttatt atgaacagct tttaggaaaa tacgcgaaaa aaaccccgga attctcatcc 2822521 ggggtttcag tcttattcag atacaggaag cacagctccg tcgtattttt tctcgatgaa 2822581 gtctttgatc tttttagagt gaagaacttc catcagcgct ttgatttttg cagaatcttc 2822641 ttcgcctttt cttactgcga tgatgttagc gtatgggttg tttttcgttg attctacttc 2822701 aattgcgtct tttttaggat ttaatttatt ttggatcgca tagtttacat tgatgaagac 2822761 cgcgtctcct tctttgtttt catatgcttt tgccgttaat tcaggcgcta cttttttgaa 2822821 ttcaaggttt ttcgggtttt tcttaatgtc tttcaatgtt gcgtcaactg tttccacttt 2822881 agaatcaaga gtgattaatc cagcgttttc aagcattgca agcatacggc cttgttcagc 2822941 aacgttgttt gtcagaatga ttgtcgcacc gtctggaagg tctttcagtg atttgtatgt 2823001 tttagagtaa ataccgaatg gctctaagtg aacagcgccg gcattcacaa gtttgtaatc 2823061 tgtgttttct ttcatttctt gctcaaggta aggaatgtgc tggaagtagt tcgcgtccac 2823121 ttctttatca gctaaagctt tattgtacat tttgtaatca ctaagcactt tcactttcag 2823181 cgtatagcct ttttctttca gcaatggttc agcttctttt aaaatttccg catgcggtgt 2823241 ttttgttgcc gcaacgacaa tttctttctt gccggattca gcgccgttat tcgaaccgca 2823301 ggcagccata actcctgcaa atacaagcag taatgcaccc aaaaatagct ttttcaatgt 2823361 aaatcctccc ttatcgtttg tctataatat ttgttattag atcaccgatg atttgaataa 2823421 taaacacgat gattaaaata aacacagtag caacgaaggt aacatcagcg ttattagact 2823481 gatatccttc tacgtacgca aggtttccaa ggcctcctga accaatggct ccggcaattg 2823541 ccgttgaacc gattaaagcg atggctgtaa ccgtaatgcc agaaataaga gcaggcattg 2823601 attccggaat cagcactttg aaaataatcg tagacgtttt cgcgcccatt gatttagctg 2823661 cttcaatcac acctttatcc acctcacgca gcgcgatttc aacaaggcgc gcgtaaaatg 2823721 gtgccgagcc gattaccagc gccggcaatg cggcgtttgg ccctaagatc gtgccgacta 2823781 aaaatttcgt aaaacctaat agtaaaataa ttaaaataag gaacggaatc gatctgaata 2823841 tgttaacaac ggctgcaatc actgagttga ccgctttatt ctgccagagg cttcctttgc 2823901 tcgtcagaaa gagcagcaag ccgaggatga ccccgatgac aaaagcaaac agtaaagaaa 2823961 tcagcgtcat ataaagtgtt tcatatgtcg cgttccataa ttcagttaaa tcaacgttcg 2824021 ggaagtattt ttcaaacatt cgtgatcacc tctgctttca cctgtttgtc attaatgaat 2824081 cggatcacgt tttgcacttc ttcctcgtcc ccgtcaatgt ggatgaacag tgaaccgtaa 2824141 gccccatcct tcgtctgcga aattttccct tgcagaatat tgacgctgac attgaagttt 2824201 ctgatcatct ctgtaatcag aggctgttca gctgactcac cgacaaatgt gagctgaacc 2824261 atttttcctg atgctgtatc atcaagaagg tgctgaagcg tctctttcgt ttcttccggc 2824321 tctgtcacct gttgaacaaa tcgttttgtc atttgttcct ttggattttt gaagacatcg 2824381 agaacctcgc cttcttcgac caccttgccg ttttccatga cggcgactct gttgcagatt 2824441 ttgcgtatga catgcatttc gtgcgtaatc agcacaatcg tcaaaccgag tctttcatta 2824501 atatcggaca atagatccag aattgaatct gtcgtttgcg gatctaatgc tgatgtcgct 2824561 tcgtcacaaa gaagaacctt cggattgttt gcaagcgctc tggcaattcc gacacgctgc 2824621 ttctgaccgc cgctcagctg ggacggataa gatttttctt ttccttctaa acctaccagt 2824681 ttaatcagtt cattggcgcg cttgatccgc tcgctctttt tcaccccggc aatttctaaa 2824741 ggaaacatga tattatctct gacagtccgc gaccaaagca aattgaaatg ctggaaaatc 2824801 atactgatct catggcgtgc ttttcttaaa ccgcgtccat ttacttcatt aatcttggtt 2824861 cccgccactt ccacggttcc tgaggttggt ttctcaaggc cgttcagcag acggattaag 2824921 gaactcttac cagctccgct atatcctata attccaaaaa tctcaccttt tttaatggaa 2824981 agcgagacgt tttggacagc attgacatct ccatgtttcg acttgtaaac ttttgaaaca 2825041 tcctgaagat tgatcaaagc aatcacctgc cttaacacta ttctaagaaa tcttccggtt 2825101 ttttctgcaa aagaaaagcc tttctgcaca cttgagcaga aaggcttata taaaatgcct 2825161 ttctctcatc tttcaaagct gaacgcttcg tgtgaattgg caccatttca acagtgttga 2825221 tggttgccgg gcttcatagg gcacttccct ccacctctct tgataagaga aatatatagt 2825281 ctttttcgtc cggaaattct taatgtagaa tagcacggcg aatgattaaa tgtcaataaa 2825341 ataaatgatg tcaactttta ctattataat aatttattat tttttaattt tttaaaatcc 2825401 tctgaaaaaa tccatttgtc agccagagaa tggcttccag ctttaacagg gccctgaatg 2825461 acccctttac tttgaggctt ccgctctgaa taaggtgctg aagggaaatg tctccgtgca 2825521 ataaatcaat aatttccgtt tggtttccgt aaaaggtcag gttggacgtt tggggcggag 2825581 aaactttttt catttctccc tgttcgttta ttgagacggt taaggcttct gcttctcctt 2825641 ggaaggtaat gagcaatgtt gaggcattca aaaggggttt taaaaacaga tgctgatact 2825701 catcttctaa aacttccgct ttctccatat gtacaacctc ctatttgttg gtcatacata 2825761 cacatttctc tctttgtcgc aagaacccct ttataaaacg aacgacaatt tcattggata 2825821 tgctgagaaa tatgtcataa atgggatgcg gaagatgatt tttgtttgat cagctcatat 2825881 aaataagaaa cggaatgaaa tgcatatcct ctttcgacca tctttccgcc tttaaacagc 2825941 agaaaacaag ggacgctttc aatttgatac gcttttgcga atgtcggaga gtaattgaca 2826001 ttgttttgat agaaggcgac atccggcagc atttctttca ccactgtcag cattttgctt 2826061 gcaagctggc aggtgccgca aaacggagta tataaatata gaaggtacac atcatcttca 2826121 atgtgatcaa gttcgtgttc ttggagttct ttcatgctat acacctcggg actttctttc 2826181 aagaaaaata gtatggacat tcagattcgc acgcagcaat acagaagcga tatggtgcct 2826241 gggcgcagcc gctacttcct tataggctct gtcgacatgg agatggcagg cttcattaaa 2826301 ttcacgcttc agctgttttc tcaatttctc acctgattca tcagcatcaa ctaatatata 2826361 gacgtcttta tcataaagct cgtcagccaa ttcctcgagc ctcagctggc tgattgttcc 2826421 gtttgtgcag ataatgcgca tcggttcatt caggacgctt tcgattttct ctttatctga 2826481 tttcccctcg acaatcataa ccttttccag ctcatccatc ttcatcttgt tcacctgccg 2826541 cgtcaaattt gaaatgttca gattgtaaaa gaaggcagtg aaattcaccg ccaacattaa 2826601 caccagccgt tttcgtagtc acaatctaca tattttgcgt cgtctccaga gaccacatcg 2826661 gctgtcttat aaaatttctc attttcaaag gaataaccgg acttaagctc atattcattc 2826721 atgcttgtca tttggccgat catctcatta tcatgatata acgagagccg gccattttga 2826781 aagcggcctg tcacgtcatt ggtgacatcg agcttttgtt tgtcgaaagc catattggac 2826841 acctcccata acgttagcgt gtccaattgc ttttacggct atcctgtttt agtcttcttg 2826901 tgtcatctct tcgtattgct ctgctgtcat cagtttttca atttcagaag cgtcagatgg 2826961 ctcaacgacg atcatccatg ctttttcgta cggagattcg ttgacgaatt ccggactgtc 2827021 atcaagatct tcgtttactt ccacaaccgt tccgttaatc ggtgcataaa gctcagatac 2827081 cgttttaacg gattcaacac tgccgaatgg ctcgtccgct ttgatttcag cgcccacttc 2827141 aggaagttcg acaaacacga tgtcgcctag ttcggactgg gcaaaatgcg taattccgat 2827201 tctggctttt tctccttcaa cttttaccca ctcgtgttct cctgagtaac gcaaatcttt 2827261 tggtatgctc aattgaatcc ctccattttt tacagcacta caataagaag ataccacact 2827321 tttcaaaaaa aatttacatt aagcccagtt ttcttcaaat tggtcttctt taaatccgac 2827381 agtcactttt tcgccgtctg ttgtaagcgg gcgtttaatt agcataccat ctgaagccag 2827441 cagttcgagc tgttcgtcct ctgacatatg atacagcttt tccttgagat tgagctcgcg 2827501 gtatttcatg ccgctcgtgt tgaaaaattt cttgagatcc agcccgcttt tttcataaag 2827561 cgcttttaat tcttctttgc ttggcggctg ctcagcaata tgtatttcgt ttatttcttt 2827621 cccatgctct tcaagccact tctttgcttt gcggcacgtt ccgcatttag ggtaccagta 2827681 aaaagttaac gacatcttct tccccctcaa taaaataatc gaggttattt taacacagtt 2827741 tgttttaaaa acctaaaaca gtgcttctta aaaaagagct ccgcgcatgc ggagctcatg 2827801 gccaatcaga cagtatattt ctcagcctca aaaatgcctg ccgccgcctc gcgttttttc 2827861 tgaatcacgt ttttaggcgt tacgcgtgtc agcttgcgca gagcggaaag catcatgcgg 2827921 agtgaatctc cttcttccat tgcgataagg gattcctttg catgcgcttc gatttcgtta 2827981 aaggcctctt gaacgaaaat ttctgtgtac agcacctttt gcgctgcttt ttcagcgcct 2828041 tgtgcggcaa tggccttttc cgttctgagc acggctgatt ccattgcgta tacattgctg 2828101 acgatatccg ctacgttcac gagaatttct tgctcacgat cgatcgcttt tccgtatttt 2828161 tgcgcggcta ggccggcagc aaacaacgca atttttttgg cttgcttgac gatatatttc 2828221 tcctgctcta agacgccgct tccaggctct tcaggcataa gcatcatgag ttcttcctgc 2828281 agcgactgcg ctttttcgaa taaaggcagc tcgcctttaa gcgctttttt caggaaggtg 2828341 cttggcacga ttaaccggtt gatttcgttt gtgccttcaa aaatccgatt gatccttgaa 2828401 tccctatagg ccctttctac ttcgtattcc tgcataaagc cgtagcctcc atgaatctgc 2828461 acgccttcat caacgatata atcaagcgtt tcagagccga ataccttatt cagagagcat 2828521 tcgatggcgt attccgcaat cgatttggcg atttgccggc cgtccttgag atcttcggcc 2828581 gtgaactggc tcatattgtc ttcaaacagc ccgacggttc tgtatacaga gctttccatc 2828641 gcatacagcc ttgaggccat tgtcccgatt ttttcctgtg tcaatgaaaa accagcaatc 2828701 ggcgttttaa attggcggcg ctgatttgcg tatgccgcag acagctcgat gacgcgttta 2828761 gatgcgccga ttgtgccaac cgccagtttg taacggccga tgtttaaaat attaaaggcg 2828821 atgacatgcc ctttgccgat ttctccgagc aggttttcct ttggcacttc agcttgatcc 2828881 agaatgaggg ttcttgtcga tgatcccttg attcccattt tcttttcttc cggtcccgtg 2828941 gagacacccg ggaactcttt ttctacaata aaggctgaaa acttgtcgcc gtctacctta 2829001 gcgtaaacta caaatacatc ggcaaaagca gagttggtaa tccactgttt ttcccctgtt 2829061 aatacataat gggttcctgc ttcattcagc acagctgttg tttttgctcc aagtgcatca 2829121 gacccagagc caggctcagt cagagcataa gcggcgatct tttcgcctga agcgagtcca 2829181 ggcaaatatt ttttcttttg ttcttctgac ccgaaaaaga cgatcggcaa ggaaccgata 2829241 ccgacatgcg cgccataaga aagagaaaag cttcccgcac gcgaaaattt ctcagtgatg 2829301 agtgccgagc tgattttatc aaggccgagc ccgccgtatt cttccggcac atcggcgcca 2829361 agcagcccta gttcgcccgc tttcttcaac agtctgacag aatgctcgaa ttgatggttt 2829421 tcgatatcat ctatatgagg gagaacatct tgctcgatgt aatcctctgt tgttttcgca 2829481 atcattttat gctcgtcagt gaaatcctcc ggtgtataca tttgatcgta tgtgacatcc 2829541 tcgattaaaa atccgccgcc tttttgtacg tcagccgctt tttttgccat ttgtttttcc 2829601 ccctttagca taattcaaat acaccggccg ctcccattcc gccgccgata cacatggtca 2829661 cgactccaaa ttgctcgttt ctccgtttca tttcatggat gagtgagagt gtaagctttg 2829721 tgcccgtaca gccaagcggg tgtccaagcg cgattgcgcc cccgttgaca ttcacttttt 2829781 cttcatcaat tcccaattcc ctgattactt gaatggcctg tgaggcaaaa gcttcattca 2829841 gttcaaacaa gccgatgtcc tgcagctgaa gtccggcaag cttcaaagcg cgcggaatcg 2829901 cttccaccgg tccgattccc atcacttccg gcggcacgcc gcctaccgca aaggagcgga 2829961 atttcacaag cggcgccagg ccaagagcat cggctttttc ccggtccatc agcatgacag 2830021 ccgccgctcc gtcactcgtt tgtgaggaat tgcccgcagt caccgtcccg tcaacggaaa 2830081 aggccgggcg caatgtcgat aagatgtctg cagtcgtttg cgggcgaaca ccttcatcct 2830141 gagaaaacac aaactgtttt tccataggct tatggtcttc tccgatttct gtcaccgtca 2830201 cttcgacggg tacaatttca tctttaaatt ttccttctgc aagggcttta gcggcgtttt 2830261 gatggctgcg aacggcaaac gcgtcttgat cctcacggga gacgccgtat tttttcgcga 2830321 cttgctcggc tgtgtgcccc atgctcatat aatattccgg tgccttttct gccaaagcaa 2830381 ggttcggacg ggtaacatgc cccatcatcg gaacttgcga catggattct gctccgccgg 2830441 cgatcgctgt atcgtaggcg cccagcataa ttttttctgc tgcatacgca atagactgaa 2830501 ggcctgaaga gcaatagcgg ttaactgtaa tcgccggaac cgtgtacggc aggcccgcga 2830561 gcgcaccgat atttctcgcc atattaagcc cctgctccgc ttcaggtgtt gcacagccga 2830621 taatcaagtc atcaatattg ccttcgtagc cgcctgcccg tttcagcgtt tcttttacac 2830681 aaatcgctcc caaatcatcc gggcgaacgg tggccaacga tccttttttt gcttttccaa 2830741 ccggtgttct tgcacctgac acaatgactg cctctttcat aagctccctc ctaattccgt 2830801 aaaggtttac ctttcacaag catatgctgc attctcgctt gagattttgc ctctcctgac 2830861 aaactcaaaa acgcttctct ttcgatctcc aataaatact cttcatcaac ctctgtacca 2830921 aacggcactt ttccgcccgc aatgacataa gcgagttttt tcgcgatctt aaaatcatgc 2830981 tcagatatat agccggacag cttcatctgc tcagcgccaa gcaagagtgc cgcataaccg 2831041 gtttctcccg gcaccttgac cttttctttt acaggcggcc gccagccggt atcgtataaa 2831101 gatgcggcca gctgcttcgc atcgtataac aggtggtctt gattcacgct gatctgatcc 2831161 gtttctttta agatgttcat ctcacgagcc tcttgagcgg aagcggacac tttcgccatc 2831221 gcgattgttt caaatgtttt cattgccgca ttcatcggat catggccgcg gcgaagatgg 2831281 ttgatgtaca gctctttgtt acctcctccg ccagggatga ggccgacacc ggattccaca 2831341 agtcccatat aggcttcgct tgccgcttga atgcgcgccg ccggcaggca tgcttccgtt 2831401 cctccgccga gcgtcatgcc aaatggcgcg gcgacgaccg gtttcgcact gtatttgatc 2831461 ttcatcatcg tctcctgaaa acggcggatc acaaaatcaa cttccaaaaa gttgtcatct 2831521 tggacttcca ttaagatcat ggcgagattc gcgccgacgc agaaattttt cccttgattg 2831581 ccgatgacaa gccccttgta attccgttct gtttcctcta atcctttgtg gatcatttga 2831641 atgatatcga ggccgatcgc attgcttttc gaatgaaatt caagaagggc cacatcatct 2831701 ccaaggtcaa ttaagcttgc tccgctgttt ttcgcaatca cgccttttgt ttctttaagt 2831761 gcttgtaaat gaattcgttt tttgttttct ttcacggctc tgtattcgcc gcggtcataa 2831821 taaaataccg ttccgttctc tttgatgtag aaggtttcat ttcctttgtc cagcatctct 2831881 tttatccagc caggcatatc tgctccaagc tgctcaagct tttccgctga ctgcttgagg 2831941 ccgatggcgt cccacatctc aaaaggtccc agttcccagc cgaatcccca cttcatggct 2832001 tggtcaatcg catgaatatc atcggcaatc tcgccaagca gctcggctga gtaaagcagg 2832061 gtttgagaag tgatattcca cagcaaacgg ccggccctgt catccgaata aataagcgct 2832121 ttcattttgg cttttgtccc ttttgcctgt tttgccgctt caagtgccgg tgatttcatt 2832181 tttgtccgct cgccgtaagt aagcgtcact gggtcaagct cataaatcgt ttttccttct 2832241 tttttataaa agccttggcc ggccttgctt ccgatccacc ctttttccag catatcgttc 2832301 atgaagcttg gaatgcgaaa cacttctttt tcatcgccat cagctttgtc atacacattt 2832361 cgggcaacgt gggcgaatgt atcgaggccg accacatcaa gcgttctaaa ggtggcgctt 2832421 ttcggcctgc cgatcagcgg tcctgtgatc gaatcaacct ccccgacctg ataaccgcct 2832481 ttcagcattt cttggactgt cacgagaagc ccgtaagtcc cgatgcggtt tgcgataaag 2832541 ttcggtgtgt cctttgctgt aacaacgcct ttcccgagga cattttctcc gaaagctgtc 2832601 ataaacttta aaatatcagg atccgtttcc ttaatcggaa tgatctctag cagctttaaa 2832661 tatcgtgcgg gattaaaaaa atgcgttcca agaaaatggg ctttaaaatc atccgaccgg 2832721 ccttcagcca tttcctgcac tgatatgccg gatgtgttgc ttgagacgat gcttccagtc 2832781 tttcgatgtt catccacaag agcgaaaatt ttctttttga cttcaaggtt ttcgacaacg 2832841 acctcaataa tccaatctgc ttctttcagt ttttctgcat catcctccag attgccaggt 2832901 gtaatatagg aggtattttt cgctgatgtg aggggagcgg gcttttgttt cagcagtttt 2832961 ttcatcgcct gccggctcag cctgctgcgc acctccgaac tgtccttcgt cagccccttt 2833021 ttttcctctt cctttgtcaa atcgttcggc acaatatcta gcagcaggac aggaattccg 2833081 atgttagcca aatgcgccgc tatcccggaa cccattaccc ccgatcctaa aacggctgcc 2833141 ttccgaatgt gtttgtgcat gagatatccc ccttgaacat tgaatgaata gtcattcatt 2833201 ttttgactaa aaaaaatgaa acccgtttct tctttcatct taaaagattt ccggttcgac 2833261 ttcaatagct aatttgttat ttttttgtat gaagcctata aaagtcgggc aacttaagcc 2833321 cggaggtgaa gggaatggta cgagagaaaa aaaatccgtc ttcagcggca gtcagcgcgg 2833381 cgagcgtaaa gggagatgcc ggtccgactc agcattacgg cggcggaaaa cggacaagtc 2833441 aaaatcagca gtataaaaaa cataacatgg gacaatcata atgcagctgc ttcccacggc 2833501 tgctttcact ttttcaaaat tccttttaac acaaacgctg cattggcagg ccgttcggca 2833561 attcttctca taaagtagct gaaccagtcc gttccatatg ggacatacac acgcattctg 2833621 tagccttcct tggcgagttc cttctgacgc tccggcctga tgccgtatag catttgaaac 2833681 tcaaattgcg atgcggggat ttgatgttcg gcgacgagct gtttcgtaaa tgcaatgatg 2833741 tcatcgtcat gtgtggcgac agccgtgtag ttcccgctta acaactgcag ctttattaag 2833801 ctctgaaaat gaaggtccgt gcctcttttg tcgggaaacg ctacagccgc agattcttta 2833861 taagcgcctt ttacaagtct gagattcggc tttaagtccc gcatctttct gatatcttct 2833921 gccgcccggt acaaatacgc ctgaatgacc gtgccgagct tctcaaattc ctgtttgcat 2833981 tgcctgtaaa tagaaagtgt ctgttcataa tgagaatagt cttccatatc aatggtcaca 2834041 gcaacatcat attgcttcgc aacggaaaga atggcgcgca aatgagtaag agcaagttct 2834101 tctgaaagat cgagcccgat tgaggtcagc ttaagtgaaa gctctgaatt caattgatgt 2834161 tcggcaatgg cttgaatggc tttcttgcat tcctctgcga cttggtttgc ttctttttcc 2834221 gaagctgcat actcgcctaa ataatcaatt gttgcacaca aaccggatct gtttagcctt 2834281 ttgacggtct taaccgccga ttcaatcgta tcccctgcga caaaccttcg tgctccaagc 2834341 cgcgttccgt atgcttttgc gaacttggta agtgttttat tttgagataa gaataaaaac 2834401 acatgtctca acatccgact ccctcccgcc gtcatcttca aaacacctgt atataactcc 2834461 cagtctgaag gaaactataa aatgaacaga aaccaaagga ggatcacaat ggataatcag 2834521 cagcaatctc aaatgccgcc ttccgttatt tcgacaaagg atcatttgta tctcaatgac 2834581 atgctgaact ggaatttgct cgcgatgaaa aaagcgcatt tcatggcgca gcagtgccag 2834641 gatcaaacgt taaagcaaga actcgaccgc gtcggacaca tgcatcatga tcactatcaa 2834701 agaatattaa agcacctgca gccaggccag cagcagtccg gctacatcca ataaggaggc 2834761 gccagaatga atcagcaaaa tcaaaaaatc agcaacccgc agacacctgt accgacaaca 2834821 tcggaaatga atgacagaga tttcgtcaac gaattgctga caaccgaaaa atacatgaca 2834881 acagcttatt gcactgcctt gcacgaattc agccacgagt ctctttatca ggatattcaa 2834941 tccatttttg atgagtcaca aaaagcgcaa agaaaactat atgatctcat gttccaatat 2835001 ggatggtatt ctgttgaagc ggaggattca caaaagctgc agcagtccta tcaaaaattc 2835061 cagcagacca ttcagcagca gtctccttat cagcaataac aacattagta aaaaggatac 2835121 gatgttcttt cgggcatcta tccttttttt gtgtaaaatc agttgacttt tcatttacgc 2835181 ttatttatat ttaataagca ttaactattt tgtcattaaa atatatatac agtgtatgta 2835241 acagagggga aatgaatatg aagagtgcgg atcagttaat gtccgatatt caattatcgc 2835301 ttcaggcgct ctttcaaaag atacagcctg aaatgctgga aagcatggag aaacaaggtg 2835361 tcaccccagc gcagctgttt gtgctggcca gcctaaagaa acacggcagc ctcaaagttt 2835421 ctgaaattgc cgagcgtatg gaggtgaagc caagcgcggt gacgctgatg gcagatcgcc 2835481 ttgaacaaaa aaatcttatc gccagaacac acaacacaaa agacaggcga gtgattgatc 2835541 tcagtcttac tgacgaagga gacataaagt tcgaggaggt tttggcgggc agaaaagcca 2835601 taatggcgcg ctatctttcc tttttgacgg aggaggaaat gctgcaggcg gcgcatatta 2835661 cagcaaaact cgcacaagca gcagaaacgg atgaaaagca aaacatgaaa agaggaaacg 2835721 gatgaaaatg agtaaagaag gcaaacaatc aaaacgaacg ttattaataa caggcttaat 2835781 tattgccatg tttttttcag cccttgacgg taccattgtc ggaacggcca tgccgaaaat 2835841 tgtcggtgat ctgggcggtt tgagcatgat gacctggctg acaactgcat atttgttaac 2835901 atcaacaacc attgttccaa ttgccggtaa actggctgat ttattgggac gccgcattgt 2835961 ctatgtatca ggtttgatta tttttatggc cgcttctgct ttgtgcggaa tggccaacaa 2836021 catgacggaa ttgattatct tccgtggact gcagggcatc ggcggaggca tcatgatgcc 2836081 gatggcgatg attgtcatcg gtgacttgtt cacaggaaaa cagcgtgcta aattccaagg 2836141 tgtctttggc gcaatttacg ggctggcttc agtgattggg ccgcaaatcg gcggctggat 2836201 tgtagactcg ttaaactgga aatgggtttt ctatattaac ctgccagtcg gaattattgc 2836261 ggttattttt attgccaggg gattacaggg acgccagcag actggtccga tcaacttcga 2836321 tatcgctggt attttcacaa tgattgtcgg tgtggtcagc ctcctgctcg ccttaagctt 2836381 tggcggaaaa gattatgcat gggattcatg gcagattctt gggttgttcg ctctcgcact 2836441 gatcggcatt gtcagcttta tcatcgtaga atcaaaagca aaagagccaa tcctgccaat 2836501 gtatttattt aaaaacagaa catttacatt tctaaacttg atcggcttct ttatgagtat 2836561 cggtatgttt ggcgccatta cgtttgttcc tttctttatg cagggaattg tcggtgtaag 2836621 tgcgtctgaa tcgggtacaa ttatgacacc gatgatgatt tctatgatta tcacaagtat 2836681 catcggcgga cagcttgttt ataaaattgg gattaaaccg caaatcatta caggcatgct 2836741 ggttatggcc ggcggattcc tgctgttaac gacattggat ctcgacacga gcaagcttgt 2836801 cgctacatct tttatggcga ttattggtct gggaatgggt cttgttatgc cgattctgac 2836861 attggcttta caggaaagct tttcgaagga ggagcttgga gttgtcactt catccagcca 2836921 attcttccgt tctatcggcg gaacattcgg cattaccatg ctgggagccg taatgaatgc 2836981 gagatcagga aatctattaa cagataaatt ggttccatat ttagactctc ttccggcaca 2837041 ggcaagctcg tttgccgccc agctaaaggg tatgattgat acaaatccgc aagggctgct 2837101 gcaatcactg ttcagtccgg acgcggtcaa acaaatccct gcggctttct catcccatat 2837161 tgtgccgatt ttaaaaacat cgttgatgga ttcgctccac agcgtgtttt atacgggcct 2837221 gatctttatc gcagtcggag ccgtattcac cttgttctta aaacctatca agctatcaaa 2837281 taagaaagcg gaagaccaac aagaaaaaga gaaggcggca aaagccgttg aatcaccttc 2837341 ccattaatag agcaccccgc gggtatcaat ccgcggggtt ttttattcaa tcatctgggc 2837401 tcttccattt ccgaaagacc aatcctcatc ctgatttccg gccagcatga taaacacatc 2837461 ttcttttctt acaccaagct cggaatgaat ccggctcgcg attgagcggt aaagtgcttt 2837521 tttctgttca gttgttcttg actgtttcag tgtaaaatga atgtatatca gttcatcagt 2837581 acgctcgact tggagataaa atggatcata aaaaaattcg cttttttcat attgtctgat 2837641 gacttggaaa tagtcatctt ccggcacatt gatttcttca atcatcgatt ggtggatagt 2837701 cctgctcagt ttttgaagcc acacttcgct tcttcccgac cgtaaatgaa tctgtacaaa 2837761 tggcatctcc ccgcatccct ttctttacag cgtctgtccg ctgtcaattg tgataatttg 2837821 gcctgtgagt gattcctgtt caattagtga acaaatcaat ttggcaacat catctggttc 2837881 agcaatacac tgcagcagca aagagccgat catgcttttc attttttctt cccgtccggc 2837941 ccaccatctc gttgccacag ctcctggtgc tacaccgctc actctgattt caggcgctaa 2838001 ggcgtgggcc aatgatttcg ttaaaccgtg caccgctgat tttgatactg cgtaaggcat 2838061 tgatgagccg gcaccagtta tccctgcgat gctgccgacg tttacgatcg ccccgtcctt 2838121 gcttttcttc atgaacggaa ccactgcccg cgcgcagaaa aacatccctt tcacattgac 2838181 ggcatacagc tcatcctaga cgtcttctgt cgcagcctca agatcatcca ttggaatatg 2838241 ccgtgtaatg ctggcattgt tgactaaaat atcaaccgtg ccgtgtgtgt tcacgattgc 2838301 ttgaatcata tcctgcacgt cgctgttttt ggatacatct gcttggatgg cgaaggcttg 2838361 cccgccagct ttttgaatca tttccactgt ttcctccgct tctgattgcg agcgtgaata 2838421 attcaccgcc acaatcgccc cacgctttgc caattccata ctggctgctt ttccgattcc 2838481 tgtgccgccc cccgttacga gagctatttt gttcaagaca ttcattgccg ccactccttg 2838541 ctgttgacta aagtatattt ctgattccat tgtaatccag ctttgatgtt acgtataatg 2838601 attgttaaag atactagata tcactcagat tgatagtaaa cgaacggagg agttcaaaat 2838661 ggaaagcgga gatttacgtg tgtttcaaat ggtagctcgt gaagggacca ttacgaaagc 2838721 agccctgcag cttggctatg tacaatcgaa tgtcacggcc agaattcaac aattggaagc 2838781 tgagctgggt accacactgt ttttgcgcca taatcggggc atgacacttt ctgcaagcgg 2838841 aaaattgctg ctggactacg caaataaaat tataggcctt cttgatgaag cgtctaaagc 2838901 gctctcatcc tccgcagaac caagcgggcc gcttatgatc ggctgcactc agacaaccgc 2838961 cgcggtaagg cttccaaagc ttctggcatc ttattatgaa gaacatccaa acgtccagct 2839021 gtctttaaca acaggacata cgcaatttct ccttgataaa gttcttcgtt atgaattgga 2839081 tggcgcgttt atcggatgcg aatgccatca tcctgagctc gaatcctatc ctgcgtttga 2839141 ggaagaacca gtagttgttt cggctgcctc cgtgcccgat gttgaggaag ccatcacaaa 2839201 gccgattctc gtttacagca caggctgttc gtatcgagaa acacttgaaa aatggctgcg 2839261 ttccgtcggt gtcacacagc cggtcattat ggaatttggg acgcttgaag caattatcgg 2839321 cggggttaca gcaggtcttg gcatctcgtt gctgccaaga acggttgtgc agaaacatga 2839381 agcagaagga tcaattcgat tgtacccgct gcctgaagct ctcagccaga tgaaaacaga 2839441 gtttattgtt cgaaaagatt cgtttatcag cagcgcgctg agaaccttta tggattcctt 2839501 tacgccagtt aaaacggctg aatcacaaaa aagcagtctg ctataatgaa cagactgctt 2839561 tttggctatt gtttgtttcg atgcgcttca tttaattcct taatatgctg aatgatctct 2839621 ttaatgccct gcttcgcgtc ggggtatgtc gcattccaat gcttagcgag cggaggcatg 2839681 cttttggcta tatgggtgta caaaatccat tgcttcactt cttcttttag ctcatcgttt 2839741 gtttcaccaa gcagaagctc agtatacttc tccagcaatc catcaagctg ctcctgaagt 2839801 ttttgttcca ttttccatct tcctttcgaa aaaacagcaa ggagctttct caattgaaag 2839861 ctccttcgct gcgttattta tccatgtgat gtgaaagccg cttcctggac aatgcatctg 2839921 cccctgccat gaggaatgca aagaggcgtt ccgaagagcg ggtcctgtgt aacctgacag 2839981 ttcatagaaa acacattttg cacaagatca caagtgatga cctcttccgg acggccttct 2840041 gcataaatcc gtttatcttt tatggccaca agatgatgcg catagcggca cgccaagttt 2840101 aagtcatgga gaaccataac aatcgtccgg tcttcctttt cattcagctc aaacagcaaa 2840161 tcaagaattt caatttgatg cgtcatgtct aaatacgtcg tcggctcgtc aagaaggatg 2840221 atatccgttt cctgggcaag cgtcatcgcg atccaagccc gctggcgctg tccgcctgac 2840281 aaagaatcaa cggcacggtc agccatgtcc tcaagctttg ttgctttaag cgctctttca 2840341 actgcttcct catcctcttt tgaccactgc ttcagccagt tttggtaagg atatcttcct 2840401 tgcttcacca gctgatgcac cgtcagcccc tctggagccg aaggaccttg gggcaggatt 2840461 gcgagctctt ttgcgacttc cttcgtcgga agcttggcaa tcgctcttcc ttccagcagc 2840521 actgaaccgc ctctcggctt catcaggcgc gctaatgaac gtaaaagtgt cgattttccg 2840581 cagccattgc tgccaataaa tacggtaatt tcacctttgg gaattgttaa attcaactca 2840641 tcaataataa cggcatcccc gtatcctaag ctcagcgttt ctgtagaaat tgcactcata 2840701 cccataaccg ctcctttttg ctggcttttt agcagcacta tgtattgcac gttttctata 2840761 tacatgcttt taagtcaatt gtcatcaatg caaatgattc cgatattcag ccatttgata 2840821 tggtcatata tccctcattg tagcagaaaa cactgacttt gaaaatcatt ttcaattagt 2840881 tttatggaca taattgacgt ttatgggttt tttatcacaa gattacttct tgatttctct 2840941 gatggagccg tccttcagct tcaattttaa atcgatatga tcataatgac tgtccagatt 2841001 aaatgctgcc agcacactgt gtatcacttc tgtttcagcc atttggtctg tcacggaaag 2841061 ctcgctcaaa atcattttca tctcatctaa cgcttcttct ccttcctgat tgacaccgga 2841121 gagcttatcc tgtatttccg ctttttcctg agtcccgttc tttgtataga ttccttcata 2841181 acggttatgc tcaccatccc cgtagctcac acgaagcgaa aaattactgt agggaacgga 2841241 cttcagctgg gtgacggctg tattttctcc ttctgcctga tgctggtctt cattgaaacg 2841301 gcagcccgca atcagaacca ctgcgagaca tacagccccg gctgctctga tcaaatgcat 2841361 atgtttcccc cctgtaggat tccatttatt ttaggtatat ccagagaatg aaatcctcat 2841421 tcagagaaga attgaaaaag ccggggcatt taacgccacg gctttttctt taagattcgg 2841481 tcatttgtaa aaaggtttcg gcgtcacgca cagccagctt gatggcattc tcccagaaat 2841541 cgcgctttgt gatgtcagcg cccaaatgct tcatcgccaa atcctccact gtcatagaag 2841601 ccgtatcgcg caatagcgcc atatacttct cttcgaatgt gtctttttct tcaagcgcca 2841661 acgcgtaaat accaagagaa aacaggtagc cgaatgtata agggaaattg taaaacggca 2841721 ccctcgtgat gtgaaaatga agctttgatg cccaaaaaag cggatgatat tcttctaacg 2841781 cattgcagta tgcctctctt tgcgcctctt ccatcagctc attcaagcgg ctggccggta 2841841 ccactccccg ctttcgttcc tcgtagaatc tcgtttcaaa tagaaatctt gcgtgaatgt 2841901 tcatgaagaa cgcaacgctt ctttgcactt tatcctccag aagaacaagc ttttcttccc 2841961 tcgtctcggc ctgctggaca gtcgcgtccg ccactatcat ctctgcaaac gttgaagctg 2842021 tttctgcaac gttcatggcg taggaacggt ttaacggcct gacgttgagc attgcttcct 2842081 gatggaacgc gtgcccgagt tcatgcgcaa gggtagagac atttgaggcg cttcccgaaa 2842141 atgtcatgaa aatccgggat tccccgctgt ccggaaaact ggtgcaaaag ccgccgactc 2842201 tttttccgct cctgtcttcc gcctcaatcc agccgtcccg aaacgctttt tcagtgaatg 2842261 aggacagctt tttgccaaac gttgaaaact ggctggtaat gatatttgcg gcttcatcat 2842321 acgaatagac ctttccgtca gaaccgatcg gtgcctcgac atcgtaccag ctgagttttt 2842381 caaggccgag catggatgct ttccggttca aaaactgaac gaacggcttc ttgttttcag 2842441 tgatgacctg ccacatcgta tcaagtgttt cttttttcat cctgttaatt tgcagcggtt 2842501 ccttcaggac attctcccag ccgcgcgctt tataggtttc aagccggaat cccgccaaat 2842561 gattcagcgt gctgctgaaa atatcttgct tgctctccca agcttggcgg aaacgttcat 2842621 atactgtttt tctgacagta cggtcttgat gatccatcat attctccgcc tgaccgacag 2842681 acaattgctt gttttcaccg ttttcctcat acgggatcgt cattttcccg acaaccatat 2842741 tgtataagtc actccaagcg tgatatccgt ccaccgcaag gtttccgatc agtttttcct 2842801 taccggggct aagcttttcg gcaaccctct gtcttctttc atttaatatg taagaaacat 2842861 cgcgcaatcc cggttttgtt aacaattcat tccacacgtc ttgattaatg tccacaagtt 2842921 tatgatctaa tgtaacgagc gacgattgaa aatctgcgga aagccgattc atgaggcctg 2842981 atgctctata gccttttgat cattgatatt ctgggcctgg aggcaagcaa caaaagcgcc 2843041 ggcctgctga agcttgacgg atgtctgttc gaataaatca agcaacgcgg tcagcccttc 2843101 agcctcttca ggcgattcag gcacctgaaa cgcatcagtc ctgtcttgaa atgcacgcag 2843161 actttgtgac agcttctcaa tataaccttt gaattcttcc gattggctcc cgcccttaaa 2843221 aaatgaatca agatcccatc tttggcctac cccttgcagc gccatatcac aaaacccctt 2843281 tccttctttc gttctattat agaacaattc tgaattattg tataaaaatt tctattacag 2843341 gcgtcatttc gtgttcagga tagtacaata gctgtagcag tttaatagga gggttaggat 2843401 gaataaaaaa atagccatcg tgacaggagc gtccagcggc ttcggtctgc tggcagctgt 2843461 aaagcttgcc cgatcatttt tcgtgatagc cacatcaaga cagcctgaaa aagcggaaca 2843521 gcttcgagaa ttggctgcag cacacaatgt gtctgattct attcacatta cagctctcga 2843581 tgtcaccgat gaacaatcta tagtctcatt cggaaaagct gttagtgctt acgccccgat 2843641 cgatttactc gttaacaacg ccggaacggc ttatggagga tttatcgagg atgtgccgat 2843701 ggaacatttc agacaacaat ttgaaacgaa tgtcttcggt gtgatccatg tgacaaaaac 2843761 cgtgctgcct tacataagaa agcatggcgg cgcaaagatt ataaacgtga gcagcatcag 2843821 cggactgaca ggattcccag cgctgtcgcc atatgtttct tccaagcatg cattggaagg 2843881 tttttctgaa agcctgcgta tcgagctgct tccgttcggt atcgaaaccg ctttgatcga 2843941 gccgggctca tacaagacat cgatctggtc aacgtcatta tcaaatttta tgtcggtgcc 2844001 tgctgacgat tcagcctatc atcaatacta taaaaagatc ctttcctatg ttcaaaaaaa 2844061 cggagaagaa agcggagatc cccaagaggt tgccgacctc atttatcaat tggcaacaaa 2844121 acagcacata aagaatttgc gatacccgat cggaaagggc atcaagctca ccctgctgtt 2844181 ccgatcgctt tttccttggt ctgcgtggga gtctatcctg aagaaaaagc tattcagctg 2844241 atctaaatta taattattat aatttagtat tgatttttat ttagtatatg atataattaa 2844301 gtcaacagat cacaaggagg acgttatctt atgaaaactg aaaacgcaaa aacaaatcaa 2844361 acattagttg agaattcact gaacacacaa ttatcaaact ggtttctttt atactctaag 2844421 ctccaccgtt tccattggta tgtgaaaggg cctcatttct ttacattgca cgagaaattt 2844481 gaagaacttt atgaccatgc ggctgaaaca gtggatacca tcgctgagcg cctgctggcg 2844541 attggcggac agcctgttgc cacagtgaaa gaatacactg agcatgcatc tatcacagac 2844601 ggcggaaacg aaacatcagc atcagaaatg gtacaagcat tggtaaacga ctacaaacaa 2844661 atcagcagcg aatctaaatt cgtgatcggc ctggctgaag aaaatcaaga caatgcgaca 2844721 gcggacttgt ttgtcggatt aattgaagaa gttgaaaaac aagtgtggat gctttcctct 2844781 tatttagggt aacaaaaaag ctgaacctta atcgggttca gctttttgtt ttttcttagc 2844841 ttgaactgct ttctgtctgc ttggtcagtg ttgcgttcaa cgttttcgtt tttccctttc 2844901 gcagcacttg gattgttgtt ttatctccga cttttaagtc tttgtaaagg atctgacgga 2844961 tatccgcact gctttccacg tctttaccgt ttagtttgac aatgacatcc tcagatttaa 2845021 tacctgcttt ttctgccggc gaatttgctt gaacttcttt tacataaaca cctttgccca 2845081 attgatctcc aaacaggccg agcgtatttt cctgataggt ttcaggaact tgtgacatgt 2845141 caatcatctg cacgcctaaa aacggacggt ccaccttccc gttttgcagc agctggtcaa 2845201 caatcggctc gacatcattg cttgggatcg caaatccaag tgattccacg ccgctttcgc 2845261 tcaccttcaa gctgttgatg ccgatgacct ggccgcttgc attgattaat gggcctccgc 2845321 tgttccccgg attgatcgct gcatcggttt gcagcacgtt catttccacc gtcccctgtg 2845381 ttgtatccac atcaattgtc cggttcagtc cgctaatgat accttgtgtc actgtaccgg 2845441 aaaactgctg tccgagcggg ttaccgatag cgattacctt ttcgccagtg cgcagctgtg 2845501 aagagtcacc aaagctcgcc acttttttta cattcttgcc gctgatttcc aaaactgcca 2845561 aatcagtaat ggtatcgctg ccgacaagct tggcagtttc cgtttctccg ttgtatagcg 2845621 taacagtcag cttgttcgcg ccttcaacga catggttgtt tgtaatgata tacgctttat 2845681 cgctgtcttt tttgaaaata acacctgacc cggttccgct ttcactttct gagctggagc 2845741 ctcctcccgt gccgaatgtg ttattttgag aggtttggat atttgagatt ccgacaatcg 2845801 taggctctaa atcctctacc atatcagcga tgtttgatgc gttcgttatc ggcgccgttg 2845861 taaaattatc agactgcacc tgtttatttg cggaagcggt ttcggtcgcc tgattttggt 2845921 ctgacggcag ataaggcgcg atgccaagca tgaggccccc gccgataata ccgcctaaaa 2845981 tcgggctcag ccatgcggct ctccgtttct tttctttttt cacagccgtt tcttgctttt 2846041 ccatttctaa agcagaagcc gtttcctgcc gtcccgcttc atacgacaca ggcgcgtcaa 2846101 gcaattcttg ttcagaatgt ccaatcagct tctggttttc tgtattctgc tgttctgtat 2846161 gtgaaggttc agtttgatgt tgatcgtttt ggccatcacg tcgataatcc atgttcttac 2846221 actcctttaa cggttattca tttatcgtta catattcatc gcatgtacaa gttcaattgt 2846281 cccaataatg aggagaaaag caaagcacca aaatagaata tgtttgatca tcctacatct 2846341 tcctcgctct ttttctcttc ctttcttccc ttaaccatat cataaacaaa cattgtggga 2846401 taaaaatgaa aagaatatgt gaaattatga aaattgcctg ccgtatgtta aaactagttt 2846461 ataatgacgt tgaaaggatg tgaagagcct tgtcatacac catttatcta gttgaagatg 2846521 aggataacct gaatgaactg ctgacgaagt atttagagaa tgagggctgg aacattacat 2846581 cttttacgaa aggtgaagac gccagaaaga aaatgacacc gtctccccac ctatggattc 2846641 tcgatatcat gctgccggat accgacggct atacattaat aaaagaaatc aaggcgaaag 2846701 atcctgacgt gccggtcatt tttatttccg cccgagatgc ggatattgac agagtgcttg 2846761 gcttagagct tggcagcaat gactacattt caaagccgtt tttgccgcgg gagctgatta 2846821 tccgtgtgca aaagctgctg cagctcgtat ataaggaagc tcctcctgtc caaaaaaatg 2846881 aaattgccgt ctcctcgtat cgggtcgctg aagacgcccg cgaggtctat gacgaaaacg 2846941 ggaatatcat caatttgacg tcaaaggaat ttgatctgct gctattattt atccatcata 2847001 aagggcatcc atactctcgt gaggatatcc tcctaaaagt gtggggacat gactacttcg 2847061 gaacagaccg ggtcgttgat gatctcgtcc ggagactgcg cagaaagatg cctgaattga 2847121 aggtggagac gatttacggt ttcggctaca ggatgatgtc atcatgaaaa acaagccgct 2847181 cgcgtttcag atatgggttg tcatatccgg catcctgtta gcgatatcga ttttactgct 2847241 tgtgttattt tcaaacacgc tgcgagattt tttcactaat gaaacgtata cgacgattga 2847301 aaatgagcag catgttctga cagagtaccg cctgccaggt tcgattgaaa ggcgctatta 2847361 cagcgaggaa gcgacggcgc cgacaactgt ccgctccgta cagcacgtgc tccttcctga 2847421 aaatgaagag gcttcttcag acaaggattt aagcattctg tcatcttcat ttatccacaa 2847481 ggtgtacaag ctggctgata agcaggaagc taaaaagaaa cgttacagcg ccgacgtcaa 2847541 tggagagaaa gtgttttttg tcattaaaaa gggactttcc gtcaatggac aatcagcgat 2847601 gatgctctct tacgcgcttg attcttatcg ggacgatttg gcctatacct tgttcaaaca 2847661 gcttctgttt attatagctg tcgtcatttt attaagctgg attccggcta tttggcttgc 2847721 aaagtattta tcaaggcctc ttgtatcatt tgaaaaacac gtcaaacgga tttctgaaca 2847781 ggattgggat gacccagtaa aagtggaccg gaaagatgaa atcggcaaat tgggccatac 2847841 catcgaagag atgcgccaaa agcttgtgca aaaggatgaa acagaaagaa ctctattgca 2847901 aaatatctct catgatttaa aaacgccggt catggtcatc agaggctata cacaatcaat 2847961 taaagacggg atttttccta aaggagacct tgaaaacact gtagatgtta ttgaatgcga 2848021 agctcttaag ctggagaaaa aaataaagga tttattatat ttaacgaagc tggattattt 2848081 agcgaagcaa aaagtgcagc acgacatgtt cagtattgtg gaagtgacag aagaagtcat 2848141 cgaacgattg aagtgggcgc ggaaagaact atcgtgggaa attgatgtag aagaggatat 2848201 tttgatgccg ggcgatccgg agcaatggaa caaactcctc gaaaacattt tggaaaatca 2848261 aatccgctat gctgagacaa aaatagaaat cagcatgaaa caagatgatc gaaatatcgt 2848321 gatcaccatt aaaaatgacg gtccgcatat tgaagatgag atgctctcca gcctctatga 2848381 gccttttaat aaagggaaga aaggcgaatt cggcattggt ctaagcatcg taaaacgaat 2848441 tttaactctt cataaggcat ctatctcaat tgaaaatgac aaaacgggtg taacataccg 2848501 catagcagtg ccaaaataga ctgtagatgt tttgcagtct atttttttat gtgaaagaat 2848561 agccgttaaa atctctgtaa tttgttttga gcggctgttt gcattgatga acccattttt 2848621 tctctgacaa ggtctgcttc ggatatttga ctttctccac tttgattcct ctgtttcgca 2848681 agcggctgat catttcgtcc aattctctca ttctagattc accctttcgc ttgagctttg 2848741 accattcggt catctcaatt tataatataa ataatacatg ataaaaaaac aagttacaat 2848801 aaggttaatt ttataacaga cggtgtgact atatggtcat atcctagcag gcctccgggc 2848861 tccgaaaggg tggaaccatt gaaggaaaaa gaaaaactga ttattgaaac agccttaaaa 2848921 ctatttgccc aaaaaggata caactcaaca tcagtccagg aaatcgcaaa agaatgcaaa 2848981 atatctaaag gcgcttttta tatttatttt ccttcgaaag aagcgcttct tctctctatg 2849041 ctgaactact attatgataa aacgtttacc cgaattttaa atattaaaac gaagggcgac 2849101 agccccagaa cggcttaccg taaacagctg accgtcctct atgaaaacat tcttgaacac 2849161 aaagatttta tcagcatgca gttgaaggag ggttctctgc cttacacaga agaagtggag 2849221 caatgcgcaa aaaaaatccg ccagtcctca cttcaatttc atatcgacag cctgctgaac 2849281 atctatggaa aaaaagcgga accgtacact gctgagcttt gttttttaat agagggcatc 2849341 agccagattt acctggaatg catgattttg ctcgggtaca ctgtgaagcc gtctcaatta 2849401 gctgatatca ttatgaatcg aattgatgat atggtaaaag gcatgtctga acgaaacgat 2849461 aagcctttca tcacattgga agaggcgagc tctttattcg gacctcttac gcacggacgg 2849521 cctgacccgc tgactgaatc aattgtgaaa agcctacgtg acaaaattaa cagcttaaac 2849581 acaaactcct ctcttgaatt atcggagagc ttggacatac ttgaagcaga aatgaagaaa 2849641 aaaacaccga agctggcgat cataaaagga atgattcata atctgacgga gtctgaagct 2849701 ctcgccaaag atgcggaaca gcttaaatat ttattaaaac agcaacatat ttagaagaac 2849761 ggctgcttaa aaagcagccg ttcttcctat tacgcctttg gttttaccat gtcttccggc 2849821 ttaaccattt cgttaaattg ctcctctgtc agcaattcaa gcttcaaagc tgcttctttg 2849881 agcgtcaatc cctctttatg ggcaagcttg gcgattttcg ccgcgttttc ataaccgata 2849941 tgcgggttca gcgccgtaac aagcattaat gaatttgaca ggttttcctg aatggtttct 2850001 ttattaggct caataccgac agcacattta tcatggaatg aattcatgcc gtcactgagc 2850061 agctgcacag attgcaggaa gttgtaaata ataacaggct taaacacgtt cagttcaaag 2850121 ttcccctgac tcgccgcaaa gccgattgtc gcatcgttcc ccatgatttg cgctgcgatc 2850181 attgttaacg cttcgctttg tgtcggattg actttaccag gcataataga gcttcccggc 2850241 tcattttcag gaatgacgat ctccccgatg ccgcagcggg gtccgcttgc gagccatctg 2850301 acatcgttcg cgattttcat taagtcagcc gcaagcgctt ttaatgcgcc atgcgcataa 2850361 gtgatttcgt catggcttgt cagcgcgtgg aatttattcg gcgagctgct gaacgtttgg 2850421 ccggtcagct tagtgatctc ttctgagaca agctctccaa actctgggtg ggcgttgata 2850481 cccgttccga cagccgttcc accaattgca agcgcacgca ttttatctgt cgcttccaaa 2850541 atcatttcct tcgaacggtc cagcatgtga acccatccgc tgatttcctg tccgagggtc 2850601 agtggcgtag catcctgaag atgcgtgcgt ccgattttga caatatcatt gtatgctttt 2850661 gctttttcat ccagtgtatt gcgaagctga tcaagcgccg gcacaagctg ctcgtaaaca 2850721 gccaaaacag cggcaacatg catcgcagtc gggaatgtgt cgtttgagct ttggcttcgg 2850781 ttcacgtcat catttggatg aatcgtttga tcagagttct tctcttttaa taaagcagtc 2850841 gcacggttgg ctaccacttc gttcatgttc atattgcttt gtgtgccgct tccggtctgc 2850901 catacgacaa gcgggaagtt gtcatcgtac ttgcctttga gcacatcatc acaaaccgct 2850961 gcaatcgctt ctgctttttc agcgtccaga ttgccgaggc gtttattagc tagagcagtg 2851021 cttcgtttta aaattgcaaa cgccttcaca acacgcatcg gcattttttc agaaccgatc 2851081 ttaaagttct ccttgcttcg ctgtgtttgg gcgccccaaa atttatcagc aggaactttt 2851141 acttctccca tggtgtctcg ttcaattctg tattccattt atgtatccct ccataacggt 2851201 tgcttcaata gatcataatt cgccaatgac acaaaaaatc ctttttattt ttcgatcttg 2851261 gcagatttta attttaattc aagatatacg cgggaatcct ttgaatattt gtattttgga 2851321 tttgtcctgc cgtactcctt tgatgtataa gagacatcat aatgctgttc aaatgatcta 2851381 atgagctgtt caatttcttc ttgttttcca gctagcctta cctgtgccac ttcgtatcct 2851441 ccgctttcat aaaaaaactt actccatgaa atactctaac acagtatatc atttttttaa 2851501 caggaaaaga taacctctac taaggttttg gataagaggt gacctcattg gaacaaacag 2851561 agtttaagga atatatacac gataatttag cattggtgct gccaaaatta aaagaaaacg 2851621 atgatctggt gaaaaacaaa aaaatgcttg cgaacggact ggttttttac tatctctatt 2851681 tcagtgaaat gactgatgag aataaggtgt cagaagccat taaaactttg attaaagatg 2851741 aggagacctt aacgcttgac caggtcaaaa aacgccttga ccagcttgac gcaagacctg 2851801 ttgaaactgc aaaaaaaacg attgaatcga ttctcaacgg caattgtgct gtgtttatca 2851861 acggattgga taaagcctat attctgacca caggaaagaa aaaaacaaga agcctgacag 2851921 agccgacaac tgaaaaagtg gttcgcggcc caaaagtagc gtttgtagag gatattgata 2851981 caaatctcgc tctgatcaga caaagaacct ctcatccgaa attgatcacc aaaaaaatca 2852041 tgatcggcga aaacaagctg aagcctgcag ccattatgta cattgaaggc aaagcaaaaa 2852101 agtccgtcat aaaagaagtg aaggcgcggc ttaaaaatat ccagctggaa gatatccagg 2852161 acagcggaac gctcgaggag ctcattgaag ataataaata ttcaccattt ccgcagatac 2852221 aaaatacgga aagacctgac aaagtatctt cagccctgtt taacggccgt gtggcaattt 2852281 tggtcgacag ttcaccattt gtgctgctgg tgccggtttc tctcggcatc ctgatgcaat 2852341 ccccggatga ctactatgaa cgctggattt cagcatctct tatccggtcg ctgcgctttg 2852401 cttctatctt tatcaccttg tttttgtcat cgatttatat aacacttgtt tccttccatc 2852461 aggggctgct gccgaccgca ctcgccgtca cgatttcggc gaacagggaa aacgtgccgt 2852521 tccctccgat atttgaagcc ctgctgatgg aagtcaccat cgagctgcta agggaagccg 2852581 gactgcgact ccccaatccg ctcggacaga cgatcggcct cgttgggggc gtagtcatcg 2852641 gacaggctgc tgtagaagcg aatctcgtca gttcgatttt ggtcattgtc gtcagtgtca 2852701 ttgccctggc atcctttacc gttcctcaat acggaatggg tctgtctttc cgggtgctgc 2852761 gttttatttc gatgttttcc gccgctattt tagggctata cggcattatt ttatttatgc 2852821 ttgtcgttta tacgcactta acgagacaaa cgagctttgg gtctccgtat ttttcgccaa 2852881 acggattctt tagcctgaaa aatacggatg actccattat ccgtctccca attaaaaaca 2852941 aaccaaaaga ggtgaataat ccaaatgagc caaaaacaga ctccactgaa acttaatacc 2853001 tttcaaggta tttctattgt tgcaaataca atgcttgggg ccggactttt aacattgccg 2853061 cgagcgctga ccactaaggc taatacgcct gacggctgga tcacgctgat attagaaggt 2853121 ttcattttta ttttcttcat ttatttaaac acgctcattc agaaaaaaca tcaataccct 2853181 tcactctttg aatatttgaa ggaagggctt gggaaatgga tcggcagcat catcggcctt 2853241 ttgatctgcg gctatttcct cggcgtagcc agcttcgaga cacgggcaat ggctgaaatg 2853301 gtgaagtttt tcctgctgga gagaacccca attcaagtca ttattttaac gtttatttgc 2853361 tgcggcattt atttaatggt tgggggctta agcgatgtgt cgcggctgtt tcccttttat 2853421 ttaacggtaa ccattattat tttgctgatt gtgttcggga tcagttttaa aatttttgat 2853481 atcaataatt tgcgtcctgt tttaggcgaa ggccttggac ccattgcaaa ctcccttacc 2853541 gtcgtttcca tctctttttt aggaatggaa gtgatgctgt ttcttcctga acatatgaag 2853601 aaaaagaaat acacgttcag atatgcgtct ctaggatttc tgattccgat tatcttatat 2853661 atccttacgt atattatcgt tgtcggagct ttgaccgctc ccgaggtgaa aacgctgatt 2853721 tggccgacta tttctctctt tcagtccttt gagcttaaag gcatatttat tgaacggttt 2853781 gaatcctttt tactggtggt ctggattatc cagtttttca ccacatttgt catttacgga 2853841 tactttgccg ctaacgggct aaagaagaca tttggattat cgactaaaac aagcatggtg 2853901 attatcggca taacggtctt ttatttttct ctctggccgg atgacgccaa tcaagtcatg 2853961 atgtatagcg attatcttgg ctatattttt gtctccctgt ttctgcttcc gttcattctc 2854021 tttttcattg tagctctcaa gaggaggatt acaacaaaat gaaaatccgg attttatgta 2854081 tgtttatatg caccctattg ctgtccggat gctgggacag tgagaatatc gaggaattaa 2854141 gcttagtgat cggaataggg ctagacaagc ctgacgatga aaatttagag ctgacacagc 2854201 aaattctcgt gccgaaaata atcagcgcca aggagggctc ttcatctgat ccgacacagc 2854261 tttctatcac aaagggtaaa actgtccatc aaatgatgag aacctctgca ttaaagcata 2854321 agcctacgtt ttcacagcat ttgcgtctca ttctgctttc caaaagcgtg attgcggatc 2854381 aaattggaat ggacgccatt attaaccagt ttgtcagaga caacggaaca aggaggagtt 2854441 cctacgtctt tatcaccaac ggccgaacta aggatatatt taacatgaat gatgaaggcg 2854501 aacccgcatc caacgtgata tatgatctga cagagaataa taaggtgacg atcagaacga 2854561 tggagccagt tacattgggg gagatctcag aacacttaac ctctgacgat tcattcctca 2854621 tccctcatgt cggtaaggaa aacggcaagc tcgcgataaa cggagcctct atcataaaaa 2854681 ataaattatg gcaccgggac ctcaccccga ttgaggttca aaatatcagc ttattttcag 2854741 gcactgtcga gggaggcgtc attgacttga agcgcgatgg ccatctcttt tcttatgaag 2854801 tatattcaag caatcggaag atcaagacgg catacaagga cggaaagttc aaattcaccg 2854861 ttacccgcaa tattgaaggt cgtctatctg aggactggaa tcccaatgaa gactcgttta 2854921 aggattcata tattaaaagt attgaaaaga cagtcgaaaa acgagtacac gaaacagtaa 2854981 cgtcatttat tacagagaag ctgcagaaag agatcaaagc ggacgtaacc gggctgggaa 2855041 acgaggtcag aattcattat cctcaaaagt ggaaaaagat ttcaagaaaa tgggatgatg 2855101 attatttcag caatgcggaa atagactacc gggtcaatgt gattgtcaga gacttcggaa 2855161 cgaaaggcgc aaacaaatag cagccgccta attcacgaga tgatttcggt gtgcgtacac 2855221 cgccgcctgc gtccggtcac tgacatccag ctttgataaa atattcgtaa tatgtgtttt 2855281 gactgtttta atcgtaataa acagttcctc gcctatttct ttgtttgtct ttccttctgc 2855341 gatcaggcag agtatttcga gctcccgttt tgtaagcgat tcatgcggga gcgcgttttc 2855401 acctgagtgg cgcagcctgg ataatacttt tcccgccact tttgactcca gcttcggctc 2855461 tcccttgctt gcggcgcgga tggcatcggc gatttctgcc gcttttgagg ttttcaacag 2855521 atagctgagc gcgccagctt caataaccgg gtacactttg tcatcatcaa tgaagctagt 2855581 gagcacaata attttcgggt cggaaagctc ccggcaaatt tgctttgtag cttcaatgcc 2855641 atccatgccc tccatgacaa ggtccattaa aatgacatca ggcgacagtt ccacagcaag 2855701 ccgaacacct tcgctgccgt ccgatgcttc gccgatgact tcaatatcgg gctgcgcctc 2855761 caaaaaagcc gcgagcccca ttctgaccat ttcatgatca tcaatcaata atactcgaat 2855821 cacgttcgtt ctctcctttt tcttccggaa aaatcgggac cttcacttcg atttgagtgc 2855881 cttttccttc tactgaaatc acttcggcga caccgccgat ttcacttgca cgttctttca 2855941 tagaattcaa gccgtatgag gaggctttca cctggtccat tttaaagcct tttccattat 2856001 caatcacctt cagacggagc tggctgttct ttatgcccag aatcacggtt acttttgacg 2856061 cttttgaatg tctaaatacg tttgaaaggg cctcctgcac gattctgaac aagtggtctt 2856121 caacaccctt ggatatcgct gtgtcctgta tatcccactc aatatcaatc ggctgctttt 2856181 ttcggaactc gtccaaaagc tccgtaaggc cctccttcag cccttttcct tcaagggtaa 2856241 caggccgtaa atggagcagc agcgccctca tctcattttg ggcttcgcct gccatatgct 2856301 cgaccatcct gatccgcttg actgttttgt catcagcatc cttgacatgt tccagcacgg 2856361 ctgatgtcat catcgatatg gcaaagagct gctggctgac cgcatcatga agatctctgg 2856421 ccaatcgctg gcgttcttct gagataaccg acttcttcat ttgagcctgc cattccgcac 2856481 gttcattgga aagtttctgg agggatgcga cttgaagctc cacgcgcttc gccatttcgt 2856541 tcagctgatc agcagccagg ccgatttcat catcaccgag cggcggtatc cgataagcga 2856601 aattgccgtt ttcaaaggtt aaaatggatt caattaatgt atcaatcctt gtcttcaacc 2856661 ggttgccgta catataccct gaggcgaaac cgacggtcac gctgatcaga agcaaaatca 2856721 ggataaacgg aattccgaac cagcttgatg acagcaaaac aagcggatcg agccgatagt 2856781 aaaacatcat aaaggaaatc aggcaaacaa aaaggagcag gctgattccc gttgtcatgc 2856841 ggatggcgcg ccattggagg ctggcaagca ttttttttct catacgtact tcacatccac 2856901 atcaccgata aataaggaaa cggacacttt tacccggcgc tttgactcgc taaaatcagt 2856961 tgacgcggca tataccttcg tgcttaatcc gcttttcttc gagccgatca gattaatgtc 2857021 tcctataaaa acagccgagc tgacagccac ttcaaggtcc gatggtacat aaatatcaac 2857081 gttaccaatg actccgctaa tgacgattgt actttctccc tcgggaatca tcgctttaga 2857141 taaatcgatt ttgatatcac cgataaaacc agagacattt aaatcgttca ggtcaaacgg 2857201 ctgcttcatc atttgcagct caccgataaa aaagctgcgc atgtcgggat gttttacatc 2857261 ttttggcggc tcatgatgtt cttttttatt gagattgacc tgtttctcat tcggttcaaa 2857321 tatcggcttc cctttgataa gcctgtagcc ggcgtaaatc agaaatgcgg caaacgcata 2857381 gccgaataaa ttaaaggtga tgctgaagag gtttttcaaa aatagaaacg cggcaaagat 2857441 atacatgacg gagccaagcc aatcacggga atatttttta aggaaatagc cggcaatcag 2857501 aaaaaagagc ggccaaaaca gcagatcgcc tattccgata atttgcaaaa acatactgat 2857561 gccgaataaa gcaatgatca atccgagaag ctgttttttt gtcattcctg gtgtccgcct 2857621 cctttcttct gcctagtgct accgtatcgc tagatccccg ctgtccgttt tgatgtcgat 2857681 tggatgccgg ccgcttcctt gcgtgcctgt gatgtgatgc tgttctttat gtcctttatc 2857741 agcaaatgaa tacggcgaac tgacgtcacc gcttgctgat aaagcattga ctgcaaagct 2857801 gccattttgg ggaaggctta cattagcatc accgcttgtc agcgtgacag atacgggacc 2857861 ggttaccttt ttcaatacag cattaaaatc tcctgaagtc attttcacat caagagagcc 2857921 tgatacatga accagatttg cgtcccctga agctaaatca atgccggctg ttttggagac 2857981 ggtatttgaa atggaaacat cccccgatga tgccttcact ttcagatctt gaatgcggac 2858041 gtccgtcacg ctcgtatttc cgctcgcaga tactgcgttc agcccggaaa gcgcaagatg 2858101 gtcattcccg gccacagaca cgtcaccgct tgaggttcgt actgccagat cacctttata 2858161 atcatacgga agcctgacga taagagttga acggttaaat ccattcaaaa attgaaattc 2858221 tttttccttt acggtcagct ccagttttct tttgttttca gtaacaaata actttcctga 2858281 gtctcctgaa atgcctgccg atatgtcact tcgttcttcc gctataatcc ggacatcctt 2858341 gctatccgac tcaatgacca tgctgtcaat gtcccgcggc gatgcgctgg ctgaatcagc 2858401 ttctgtgcca tttatgaaac ctaggcctgc agcaaacaca tcttttacga cgacggcgaa 2858461 aaaaaccaga ataccggcag tgatcaacag tttgccaagc atttttttca ttcggtttca 2858521 tccttctcat tcattctatt ataaaggaaa agcttgcgaa ttgatacgtg cggaagggaa 2858581 ggacttgacc gcaaatcctt ccccgttccg cttattcatt tgccgctttt gtctggtctg 2858641 atttttgcag tgaaagtgtc cgcatttttt caatctccgc ttccacatcg tctgcgaatt 2858701 ctttacgtgt aagttctgtg ccggcttccg ctgactttga ataattcgcg cggatttcca 2858761 tttcttcaat acgattttca atacgtaaaa attcacgata cgcgctttca ctgtcaattt 2858821 tgtcaaatgt cgtattcata tgctctttag ctttcgccgc atttgcccgc gcaatcagcg 2858881 cctgtttttt atcctttacg tcctgaagct ttgtttcaag tgcagccagc tgctctttca 2858941 gatcagccag ctgactgttt gcctgttcat aggaagcttt atgctcagcc gccttccctt 2859001 ctaaatactt catttcagtc agcgcctttt tcgccagttc ttcttcacct gcgtcaaatg 2859061 cgagctgtgc ctgatttttc cgtttgccag ccacttcagc ggcttcttca tattttttct 2859121 taaattgata ggcaatcgtg tgctgtttca caattgtttg ctttgctttt gcgatgtcgc 2859181 tttccatatc gcgtacatat tgattcagca tcacctttgg attctccatt ttatcaagtc 2859241 cttcatgaac tgacgcaaca aacatgtctc tgattctttt taataccata cctgattcct 2859301 cctaatatat tgatattatt ttttcttcaa aaattcttcc cattcgtcat caaagtgaga 2859361 ttggtaggca gcagaagccg gttcaggatc aaaagatgat acaccgttat cagctgatcc 2859421 gtttttcatc agcttccagc cgtaatacac catagcggcc gccaatgcga ttccgacgac 2859481 aaacggaagt gagcagatga gcataatggc tccgataccg cccacgatga ttcccgtgat 2859541 ggtttttccc gcggcaaacc ttttgattcc tgcgtatgtc atcaagctcc cgatggcgag 2859601 cgggatgata aagccgaagc ttcctcctcc aaaaaagacg gagatcccaa atacaattaa 2859661 taagaatccg cctattgttt tcttgtttat tttcatgcag atcctccttt cgttttcctt 2859721 gtcttcatct tatacaagtt ggaagatatg caaaacgaat cagagattga tttttatata 2859781 agaccggagt cgtatctcgc accggaccca ttggcacaaa aaaacgccat gcacgaggca 2859841 tggcgtttta aaacccttta cagatgaaca cttgcttccc tttctttaat taggtcggac 2859901 ctttctgctt tggccaattt tgtaaacagc aagattccga tacccgcaat aatttcgaca 2859961 atcccaccga cagcgatcac tttacctgag ccgaaagcat tagcggcata cccgcaaatg 2860021 acagctccgg cagggatcga aatatttgag atcatatgta taacggcgta aacctgcggc 2860081 tgatcctcac tatccacaga cgtctggata atcgtgtact caggaacatt aacagcactg 2860141 actgcggcac caaaggtaaa agcagcgaaa aagacgagcg gcaaaaaggt attcatcccg 2860201 gtaataaaga aagcaaatcc ttcaataatg ccggcagtga cgaataacaa gccgtacctg 2860261 tttaccttga ctttcgccag cacaaaccct aataaaaacg cgcccgcggc ggtggtggcc 2860321 tttaaaagcg agtatacgat cggctggccg tttaaatctt ccgcaacgta tacggcagag 2860381 agcgcttccc atggggcagc cgcgaaattc ataaagatac agtaaatggc gagcggatat 2860441 aaaatctggt gttttctgac gagcctaaag ccgcgtttca gtcttccgat atatgtgcct 2860501 ctctgtgtaa caaccgcaga ctctgattga gattcaaccg cagtgtactt aataaaaaga 2860561 acgagaaaac ctgacaccaa atagagcaca agtgcgataa gcatggtata agaaggacta 2860621 ataaatgtaa gaaaagcgcc gcataatgtg acagccccaa gccggacaat ttgagcggag 2860681 gattgcagca cagcgtttgc tttttgaatg ccctgttcat tgacgatttg aggaatcaaa 2860741 gcgatagagg cgggattgta ggcagctcca gtagctgaat gcacaatcat aagcgtcatg 2860801 acaaaccaca gcggagagaa gcccgcaaaa tgacatagag ggataatcaa aacaatcgcc 2860861 gcccttgtca gatctgaaaa gtacatccaa aatttcagcg tggtctgttt cataaaaggc 2860921 cccgtcacag gcgccagaac ggcttccggc aaaaacgtga cagcaatcaa taaagcagtg 2860981 ccgatcgcac ctttgccgtc ataaattaaa aaccataata ttgaattaaa tgcgaacata 2861041 tcgccggata tcttgactat tcttgagaaa aacagataat tgaaatttct cttccagatg 2861101 ctatcacttt caattaaatt caccatccat cagagccccc cgttgcctat tttttacatc 2861161 tatttattac aatatctcat ttttccattt ttcagtcaat aattcataag gttcattttt 2861221 tgtcgtaaaa tgggaaattg acagagtgaa aaacaaaaaa agccggcatg tatttgaaca 2861281 cgccggcttt ccttttcact ttttatgatt cgctgctgtt tcggtcccga aacacaatgg 2861341 cacttctttc atattctaca tcgccaatac cgcttcttgc attcacaacc cgggcggcgg 2861401 caaagaaata atcggacaga cgattgagat aacgcagcac tgtttcatga atctcctccg 2861461 atttcatcag cgccaccact cttcgttctg cccgccttgt aatggtgcgt gcgatatgga 2861521 gaagcgaagc acactttgat ccgcctggaa gaataaattt cttcagttcc ggcgcttctg 2861581 ctgtataggc atcaatgcgc gtttctaaaa aggaaacaga ttcttccgtt agtttatagt 2861641 cttttctttc tgtgacgatt gccagatcgc ctccgcagtc aaacagctca tgctggatgg 2861701 tcagcagctc ggctgtcaga tcttcaaagc cgggctgccc ggaaagctct gccaaagcaa 2861761 gcccgataaa gctgttaagc tcgtcaatcg tgccgtagct ttcgacgcgt aggctgtcct 2861821 tgtccgttct gcccccgact aagcccgttt gtcccttatc gcctgttttt gtatatagtt 2861881 tcataccctg aatctccttt acagacttat tcaaacaact cagcagcctc ttttatacat 2861941 tcagctgtcc ctttctttat caattggttc agccgctgtt ctatgttttc tgattgctga 2862001 gtttgagtcg cggcgatgag aatatcacct gtgcctcctc cgtctcccag cactttcgtc 2862061 cgttctgctt cggcagccat aagagctttg atgaagaatt gatctgccgc atagccgtta 2862121 atcaaaatcc aaatcgaaaa gccggtctga acgcatatga aaacggataa ctctccgtct 2862181 tcatatgttc gatacacgaa acggtcaagt ctttctgaag aagccatcgc acacgtctcc 2862241 tgcagttgaa aaccgctttc tgaaagacag gccgtaagtc cttctatcgg atctggctga 2862301 tctggcagcc gtttatggat cagcgtcctg ctccacgaaa accctgcacc gataggcgtg 2862361 gaggacaatg ttcgaagcgg gatttccgtt tgcagaagaa tgtcatcacg ccccgcttgg 2862421 agcaatgctt caaatgggat agactgccgc ttcacgctat ctttttcagg ctgaatcaca 2862481 atcatcggtt taggtgagct ttgatgaacc aaggcggtga catctgtatc gtacaccgcc 2862541 tttatgcttt gttctgtaac agcatattcc ggtttttgct taggcccggc ggtaccgttt 2862601 ttcataaaca tgagcccatc acagtacagg cttgcggtgt tcagatcatg aaaaacgctg 2862661 acagctgcca atccgctttc tctcgtcagg cgtttgatca gatcaagcag gtctttttga 2862721 taagccagat cgagaaaatt agtcggctcg tccaaaaata aaatacgcgg ctgctgcgcc 2862781 aaagcttgtg ccaaatacac ccgctgctgt tcccctccgc ttagttcgcg aatcggcttt 2862841 tgcgcaaaat cggccactcc tgtttgctcc attgcttcct gtacaatggc ttcacccttt 2862901 tcagtctgct gtctgaacag ccccgtttgg aatggatatc tgccaaaggc tacagtttct 2862961 tcgacagtaa aggtgaaggc ttgatccatt ttttgcggca ggacagccat gatttgcgcc 2863021 agttccttcg gtttatagtc cgccagcagt tttccggcca gataaaccct gcctttcttg 2863081 gccggcagcg tacctgtcag caagtgcaaa agcgtggttt ttccgcttcc attagggccg 2863141 agaattccaa gaaattctcc cttctccact gttaagctga cattgttgat taggcggctg 2863201 tcgccgtatc ctcccgacag cccttctgcc ttcatcataa gcttctcccc ccgcgatgct 2863261 gccgaattaa aataagagcg aacacaggcg ctcccgccaa ggacgtaatg atcccgatcg 2863321 gcagttcaat cggctcaatg atggttctgg aaagcagatc ggctaaaaca agaaaccctg 2863381 ccccaagcaa ggcggacaac ggcagtaaat gccgatggtc cgttccccac aaaagccttg 2863441 tgatatgcgg aatcacaagg ccgacaaagc caatcgtacc cgatactgcc acagcgcttc 2863501 ccgtcaaaag agatccggct attaaaatca tcatcttcct ctgctgaacg ctgactccaa 2863561 gaagctttgc tttatcttct ccatatgtca tcacgttcag ttcccttccg tttataatca 2863621 ataaaatggt tcccaaaaga aaaaacggga gaaacaaaat aacatagctc cagcccctca 2863681 ttgagacgct gccaagcagc caatgcacaa tcggaagcag gttgtctcct gtcaaggcga 2863741 tgataagaga aataaatgcg cctaaaaaag agttggtgat gacaccggtc aaaatgaggg 2863801 tggaaacaga catcgaagca tgaacgaggc ggctgaagaa aaggaccgcc gccatcgtgg 2863861 ccagtgccgc ggctacactc aaaaccggga gtgtaaaccc tccgatgaca ggaaggtgca 2863921 aacctaagaa cagagtcaca acagctccga ctgaagcacc ggatgacaca cctagcgtat 2863981 agggatcagc aagcggattt ttcaacaatc cttgaaaagc ggcccctgca atagaaagag 2864041 ccgcccccac aagggcggcc agcacaactc tcggcagtct gatattcatc ataatattag 2864101 tgtacatcgg atcatcagaa ccgatagagc cgccgaaacc ttgatgccaa aagacacgaa 2864161 aaacagcggg aataggaata tgcaggctgc cgcaagaaat tcctaagatg atgctcacgg 2864221 ctaaaaatga gaaaccaatg atatatgcgg cataacgatt attccttaaa cgtatccggg 2864281 taaatgcttt ccgcaagttc ttcgacccct tcgatcagac ggggaccgga acgtgtcaca 2864341 agatcagggt ccacatcata tacacgatga tgtttcacag cattgatttc gctccagcca 2864401 tcgcgttttt ccacagcttt cgctttcaca ccgtccgttg taacaattgc atcaggattg 2864461 agttttacga tcgcctcgtc tgtcatttgc acccatcctg tctgatccgc agctgcgttt 2864521 ttagcatgga tgacatttag catttcattc ataaacgtat cttttccggt tgtataaatg 2864581 tcaggatcag gagaaacctc gataaatacg cttttctcct cgtcttttga aatggttttc 2864641 gctttttctt gaatatcctt tagatctgat ttcatgcttt tcacgagctg atcggctttt 2864701 ttctccgccc cgccagcttc tccgatcatt tcgattgatt tgtacacctc ggagaatgat 2864761 tgtgcatcat tgacagtcag cactgtaatg cccgcgtcct tcagctgttt gatggcatcc 2864821 gctgatgctg acatggaaga ctcatgggcc agaacgagat ctggttttag agaaatgact 2864881 ttttcaacgt ttacattcat atctccgact ttctcaacct ttttgacttc ctttggatag 2864941 gtatcgtttg tggtgacacc gaccactttg tcaccaaggc cgagtgcgta tgtaatttct 2865001 gtgttgctcg gcattaatga aacaatcttt tttggctctt ttttgatggt tacatcttgg 2865061 tttgacgcat catcaatggt gacagggaac acttctgttt tttgttttgc ctttgaatcc 2865121 ttctgatccg caggattgcc gcagcctgcc agcataacag cagccaacag aagcgcagcc 2865181 catatcccgg ctcgtttttt cataatcttt tcctcctaaa cgaactaaaa aagcatctct 2865241 acgacggtaa agatgctgta aacaacacaa aaaagcctat tgtttacaca tcatctgtcc 2865301 tcgcagaatt cgtgctgatc aaacaggcag gtatcctggc tcttggcgct tggccaatta 2865361 cagtggcggg accgcaccgg cttttaccgg tttccctttt aagccggctg ttgttcacgg 2865421 accggcacct atttgacatt cgtatccgtt tttcggagta attatactat atgactgaca 2865481 ggcttgtata tgtgtcctga atgacttttc cccatattgt gtatggaagc aaaatcctcg 2865541 taaacactaa atttgatctt gtatacttaa taccatcatc tatcaaaagg aatgattctt 2865601 atggatttac agctaaaaga aaaactcgtc ttaatcaccg gctcgacgtc cggtatcggg 2865661 aaagccgccg caaaaagctt tctgcaagag ggtgcggcag tcattgtcaa cggacgcaaa 2865721 caggagactg tcgatcgcac cattgaagag ctttctggct atggaacagt gcacggtgct 2865781 gctgccgatt tgtcaaaaac agatgaagca gcggctttta tcgaaaaagt aaatgaaatc 2865841 ggtgatatcg atatccttgt caacaacctt ggtttcttcg aggtaaaaga cttcgccgat 2865901 gtgacagatg aagagtggaa tcaatatttc gaagtgaacg tgatgagcgc cgttcggaca 2865961 agccgtcact tccttccaaa aatgcttgcc aaaaacagcg gccgcatttt aaatattgca 2866021 agtgaagcag gcgtcaaacc gctgccaacg atgattccat actcaatgac aaaaacggca 2866081 ctgatcagcc tttcaagagg aatggctgaa atgacaaaag gcacaaatgt gacggtcaac 2866141 tcagtgctcc cgggacctac ttggacagag ggcgtggcct cctatatgga aggcgccgca 2866201 caagcagccg gacaggatac agatacattt atcaaagact atttcaaggt caatgagcca 2866261 acctcactta ttcagcgata cgcgacagca gaagaagtcg ccaacacaat cgtattcctc 2866321 gcgtctgacg ccgcatccgc cattaacggc acggcacagc gtgtggaagg cggcattatc 2866381 cgttctctgt agtataaaaa aacgcatccg tgtttcggat gcgttttttt tatacgtctc 2866441 cagcaaatgg taccggctga tatccgcctg tttccagttg tgctgaaaac aaccctccag 2866501 cgtgaggctg ctcgtatctc tctttttctg tcatttgttc tgttgccgtt gtaatgtaaa 2866561 gggtttttaa gtctctgccg ccgaacgcgc agcacgtgac atatttagcc ggcacgctga 2866621 ttgaattgat ttcttttttc tgaaacgggt caatgtgaac aacgcggctg ccgccaaaca 2866681 gcgccaccca cagcatgcca ttttggtcaa ttgtcatgcc gtccggcaat ccgtctgact 2866741 gatcaaaacg atagacaggt tctggattcg aaacatctcc gctttgagga tcatagctgt 2866801 aacgtacaat ctcctgggtc ggcgtgtcga tgtaatacat caaattccgc tcgcggtccc 2866861 aatccaaacc gtttgaggtg gagacttgat ccttgatttt gacaagactg ccgtctagat 2866921 tcaaacggta cagcgacgcc tgtttttgct cgccttccat gctcgtcgtc cccgcccaaa 2866981 gccttccgta cgggtcacat ttagcatcat taaatctcag gctctcatgc atgtccttcg 2867041 gctgtttaat tttttccaag ctgtcatccc gaagatgata caggtaaaac ccgtccttca 2867101 tcgtcataat cagttcatcc tttgaatatt tcgcaagcgc cgtcacaaag gatttgaatt 2867161 tgattgatcg gttgattttt tcttcagggt caaagatgtg gagctcgctc cccaggatat 2867221 caacccaata taagcggccg ttctcttcat cccataacgg gccttcacca atcactgccc 2867281 gagtgtctgc ttccaatact gcatccatgt gttacacctc tttagcttca gtctatatat 2867341 tgttattccc ggcaaagagg tgtccaaacc acttgatgtt tattgttttt taaaaaggat 2867401 ggtaatgacc gttccaatgt tcgttctgct gttcacatgg atcgttccgt tatgcagatg 2867461 gacaagctcc ttggcaatcg cgagcccgag acccgttccg gcagttgaat cttttgtgtt 2867521 cgtccctctg tagtagcggt taaacaaatg ggtgatcgtt tcttcatcca ttcctttccc 2867581 attgtccttc acttttaaag aaatatgatt ttttgtttgc tccagaatga cttgaatctc 2867641 tgttcctttg ccgttgtgct tcacggcatt cccaaggagg ttttctaata tgcgcctgaa 2867701 ccacgcttca tcaagggcaa attcaatatg ctcttctttg gatacaaacg agatatcata 2867761 gccttcagaa aacggatttt tcttaaaatc ctcaatgaca tttttaaaaa acgggataag 2867821 gctagtgagc tttctctcaa taggaagagc atcatttttc aggcgatacg ttaaatttaa 2867881 gtcttcaatc agcttagaca tgtattcaga tttttctctg acaacctgcc ccatttcttt 2867941 cacttcttcc ggcgaccagt catactgctt cgactcgagc atcatgctgt agccgtaaat 2868001 gctgctgagc ggtgttttta agtcatgtga caaaccggca atccattctt cccttgtcgc 2868061 ctggattttt tctctgtttc ttttatccct tctcagcgtt tcagtcagct gatccattga 2868121 ttcaaatatc tcaccgaaga agcggtacgg ctgtttgatt tttccctttt tatttttgct 2868181 gacaggacgg ccttcccggt ttctgggctc ctcaagcttc ccttttgaca gattgaccag 2868241 ccatctaatc gtgtgaaaaa tcggcagccc gaatcggaac atataccaaa cggtcatcca 2868301 aatgatatac atgaacaaaa cggccatcac gagaaacatc gcttttaata caaccttcag 2868361 gaatgatttg ttaaactcct gatcggttac atagactggg ttcggcaccg tagcgaccat 2868421 ccatctgtct ttattgagga tcttaacgga aatttcccgc ttatagttcc aaggcttaga 2868481 gctgtattta agcagctcca gctggttcat cgtttttctc tcgctttttg tgctgttgat 2868541 gctgtcgaga atctttccat tgctgtctaa caggtaaatg gcgccttttt tccgtttaat 2868601 atagtcgatg gtactagact tatagtgcgc tagtgagtct atcttttgtt cacgcttttc 2868661 aacggaagtc aggagctgtt cactttttga tttccagccg gacaatagaa gatacgactt 2868721 atcttcaata ttgatggccc aataattcag tttatagtta tgaagctttt tggttttata 2868781 aatagacaaa agctctttct tggtataggt gcccggcacg tcttttggca cgccgtagga 2868841 ataatcagtg tttccttccg aatcaatgat ttgcatccag ccgtgctgtt tatcaacaga 2868901 tttcttcagg aaattatcca cttcccatgt cccgtcttcg tttacatcga gatatgcctc 2868961 aagtgtgtcg gtcgttgctt tcgtcagccc tgaattggat tccgcatcgc taaaacgggc 2869021 gtctaaatag aaaaacgatg caacaagcat aaccgtaagc agcaggatca caatcagcat 2869081 ctggccgaaa aagtgaaaca aaaacttcca tcttaacctc atgaccgctt gccttcagga 2869141 tttgggataa aacgatagcc gagacctcga acggttacaa tatactccgg attgctcgga 2869201 tcgcgctcaa tcttctccct aagcttgcga atatgaacca tgacggtgtt gttgtcaccg 2869261 taggaaggat agccccatac tttttcatat atttgatctt tggaaagcac cacgttaggg 2869321 tgttcacaaa aatactgcaa aagctgcaga agctgggctg aacaggcaac ggcttccccg 2869381 cctacgatca actcggcatt ttgcggagaa aaagtaaagt aatcatatgt gtaggtttga 2869441 tttgaactcg tttctttcga ttgatatgta cgcttgagat gcgctctgat ccgcgccgct 2869501 aattccagcg gattaaatgg ttttgtgata tagtcatcag ctccaaccgc aaagcccgat 2869561 aatttgtccg cgtcggatga tcttgccgtc aggaaaaaaa tcggagcgtc tgaatactct 2869621 ctgatcaatg tgcaggcttc aaaaccggac attccgccca tcatgacatc cagcacaatc 2869681 aagtcaacct tattggcctt cacaacggga atcgcttctt ctgcgcttgc cgcatccagt 2869741 atatttcgat aaccttcttt ttcgagaacg cgtttgatca tgtccacaat cgctttctca 2869801 tcgtctacga ttaaaattga cgcattttcc acttttatgt tcctttctgt cactgttttt 2869861 ttcatcttat cattatatcg tttatttatg gtacattttt gaatacattg gagccttggc 2869921 aaatcaaaac agcaaaaaag gagcaaacaa gcgctccctt ttgatgtttt ttcatatgaa 2869981 aatattatga gttctcatct accatgtaca aaataaactc ccaaaacccc ggtacatcct 2870041 gacataaaag catatcagcc ttttcaaaca ttttgatctt cagctcttgc tctaaatctt 2870101 ctctttcttg ataggacgta ttgctgagtt tttttctgat catcggtgaa aagcatgcaa 2870161 tcaggtgctc aatgtcataa gtctcgtctt tttgtttctt tttttgttca aactggccgt 2870221 ccacagctta cttttccccc tttttttgcg ccgctaactg ctttctgata ttctccagcc 2870281 cctttttatg aatgttggag atgttttgtc gggactcccc taatgaatct gcaatctcct 2870341 gcatcgtggc accgtgaaga tagactttcg tcagcacact tttttgtttg tcagtcagct 2870401 tctggatcgc ttggtagagc tggtaatcct gtacatgctg gctcaaatca tcctgcctgt 2870461 ctaaaaattc ttcaaatgca tcgctacctg tttcggaaga aagccgatct cccgcctccg 2870521 gatgatcaac cgtcagtgga taccgttttt ggtttttgcg aacccgctta tcaaaatcaa 2870581 tagaaaagat gcgaatcatt gaattcatat acttgacgat gcggatttct ttataaaatt 2870641 gcttaaatag ctcgtccaat gatcttgcat ctttttcgtt agggctttcc attacgtttt 2870701 tgaacaaacg gtaatgctga ggattgctca aaaaatgctt cacgatggga tgcttcatta 2870761 tctccttaca ttttgaccgt aaaagacttt gatagtccat caaaccgcct ccctactaaa 2870821 ttaaatgaag gaaagcaaaa aaaagtaaac tactactttc cgcctagtgt cttccaaaat 2870881 actttgcagc agtttacgtt ttatcggttt tcctcactta catacatgac tgcagaaaaa 2870941 gaagggaggt attttcctat ggatcaggtt tttatagagg aagtcgtaaa acagatcggc 2871001 aatttggggt ttcccgcgct gattgcaatg tatctgctga cccgattcga aaagaagttt 2871061 gatcaactaa tagaactaat gacagaactg aaagatcatg caaaaaaata atttttcaat 2871121 cgaagttgac ttttcactgg tttttttcac ttaacaaaac agaagggaaa acgaaaggcc 2871181 tttcaccttc tctttctgct atcacattta aatgtaagga ggaaacattt catgaaaaaa 2871241 caaaatgaca ttccgcagcc aattagagga gacaaaggag caacggtaaa aatcccgcgc 2871301 aatattgaaa gagaccggca aaaccctgat atgctcgttc cgcctgaaac cgatcatggc 2871361 accgtcagca atatgaagtt ttcattctct gatactcata accgattaga aaaaggcgga 2871421 tatgcccggg aagtgacagt acgtgaattg ccgatttcag aaaaccttgc atccgtaaat 2871481 atgcggctga agccaggcgc gattcgcgag cttcactggc ataaagaagc tgaatgggct 2871541 tatatgattt acggaagtgc aagagtcaca attgtagatg aaaaagggcg cagctttatt 2871601 gacgatgtag gtgaaggaga cctttggtac ttcccgtcag gcctgccgca ctccatccaa 2871661 gcgctggagg agggagctga gttcctgctc gtgtttgacg atggatcatt ctctgaaaac 2871721 agcacgttcc agctgacaga ttggctggcc cacactccaa aagaagtcat tgctgcgaac 2871781 ttcggcgtga caaaagaaga gatttccaat ttgcctggca aagaaaaata tatatttgaa 2871841 aaccaacttc ctggcagttt aaaagatgat attgtggaag ggccgaatgg cgaagtgcct 2871901 tatccattta cttaccgcct tcttgaacaa gagccgatcg aatctgaggg aggaaaagta 2871961 tacattgcag attcgacaaa cttcaaagtg tctaaaacca tcgcatcagc gctcgtaaca 2872021 gtagaacccg gcgccatgag agaactgcac tggcacccga atacccacga atggcaatac 2872081 tacatctccg gtaaagctag aatgaccgtt tttgcatctg acggccatgc cagaacgttt 2872141 aattaccaag ccggtgatgt cggatatgta ccatttgcaa tgggtcatta cgttgaaaac 2872201 atcggggatg aaccgcttgt ctttttagaa atcttcaaag acgaccatta tgctgatgta 2872261 tctttaaacc aatggcttgc catgcttcct gaaacatttg ttcaagcgca ccttgacttg 2872321 ggcaaagact ttactgatgt gctttcaaaa gaaaagcacc cagtagtgaa aaagaaatgc 2872381 agtaaataaa agacttgcgg cttgcagaga gcactcgttc tctgcaagcc ttcataagga 2872441 gctgaaccag tgaaacatca aaacccttca aaacgcttat tgcggctctc cataaagtac 2872501 ttgctggccg cagcagcagt ggtgttgacc tattttgctg tcatctatat attgttttct 2872561 ttagcgggaa cgagctaccg ctcagcagct catgtcctgc tttttgccgt ggtattcctt 2872621 gttctcggat tatgctttga accatttgaa cggctgatga tacatagctt tacatttttc 2872681 aagacaggaa aacgtctatt cattctcctt gctggcatcg tacagctgct gtttttgtgg 2872741 atgactgctc atacaacaga ccaattgatc agcgacatct ggctgtccac cacagaagaa 2872801 atgattgtcg cagccgtttt tttgatttta gacaaatgca actcggctct tcccagctaa 2872861 aaaaagaacg cattccaatt ggatgcgttc tttttattca tagcgaagcg cgtctacagg 2872921 ctgaagcttc gaagccttga tagacggaag caagccgaag ataatgccga ctgccattga 2872981 aaagatgagt gctccgacaa cagctggaat ggagacgata aaaggcatcg gaaaaatgac 2873041 cgtcagcagc ttggcgatgc cgaagcccgc cagcacaccg agtattccgc caatgcttgt 2873101 cagcacgaca gcctcggtta aaaattgaaa taaaatcaca cgccgcttag caccgagcgc 2873161 tttcttaatt ccgatttccc tcgtgcgctc cgttacggaa acgagcataa tgttcatgac 2873221 gccgataccg cccaccaaaa gtgaaatact ggcgataccg ccaagcagca atgcaaatga 2873281 ctgattaaag gactccactt cctgcgcgat ctcctgaaga tccattacac tgtactctgc 2873341 tttttccagc tcagcttctg acagtccctg atttaaaaga tctgcagcca ttacacccgc 2873401 ttcttggata tgctcagaag aatcagcctg cacggcaatc tgcgttggcg cgtcaaatcc 2873461 ttcaataagc ggccacactt ttttcggcac gtacaaaacc gggttcgcat agtcgccttc 2873521 aaacatgctt tcctgttgat ttttttcttt aaaaacaccc acgaccttaa acggcacacc 2873581 attcatctca atgcttttat gcagagcttc tccgtctgga aacagttcat ctctgacagc 2873641 ttcattgatc atcactactt ggtgtgtgct gtttaaatcg ttttccgtca gctttctccc 2873701 ttcggttatt cggattggaa acatgtcgaa gtaatcatcg tccactccat acacttgggg 2873761 atacgaaacg ttagttaaat gaaaaacgct cgcgccttct gacaagtaat ataaggataa 2873821 tcctttgacc atcggatctg atttgatcgc ctttactgtt tcttccgcta caggcggcgc 2873881 ggacgcatac gacacctgag ggccgccgct ctcctcttct ccgccagacg gctggtagac 2873941 aacattgatg gcgttgtttc ccatgccgat catactttgc tttaactgct cactttggcc 2874001 cttcagcatt gaaacaatcg cgatgattgc cgctatgccg ataatgacgc caagcattgt 2874061 cagaatcgat cttaatttat gagagaaaat ggattgaaag gagattcgaa tatgttcaag 2874121 catggctgat atcccctctc tcatctaata ccaactctcc gtctctgata aaaacggttc 2874181 tgtcagcttt tttggcgacg tccgggtcgt gggttatcat aataatggtc ttgccttccc 2874241 gatgcagttc agaaaacagt gccaaaattt gttcacttga tttggtatca agcgccccgg 2874301 tcggttcatc agctaaaata aacctcggct gattgacaag ggccctcgct atcgccaccc 2874361 gctgcttttg gccgccggac agcttaggcg gtttgtagga gaccctgtct tttaatccga 2874421 ctttttccag cgcttcatat gcccgttgcc ttctctcttt tttcttcact ttattgtaga 2874481 tcatcggcag ctcgacattt tgcagcgcgg tgagacgcgg cagcaaatga aaagtttgaa 2874541 acacaaaccc gattgattca ttgcgaattt cggctaaagc cccgtctttc cctttcaata 2874601 tatcgatctg gtcaagcgta taggttcctg aggttggcct gtccaaacag ccgataatat 2874661 tcattaacgt tgactttcca gaaccggaag gccccataat agctaaaaac tcccccgcct 2874721 gaacggtcag attgatatgt ttcaagattg gaacttcttc ttttcccagc ttgtacgact 2874781 tcgaaatatt attcagtgtc agcattgact gtaacctgct ttccttcctt gaccgcggga 2874841 tcaggataga tcacataatc ttccggcgtc aggccgctct taatttccac catgtcattt 2874901 tcatcagtct ctccgatttc aacaggctgc ttaaccgctt tgtgattctc atcagctttc 2874961 catacgtacg gttcgccgtc atcctgaatg accatgtcgg acggcagctt gatcgtgtcc 2875021 gcatcagcat tatcactcat cacttcgatg ttgacatgat agccgacttc aagaccttta 2875081 tggctgtcta ataaaatggt gaaaggatag ttagaggact ggggattcat ttcttcatca 2875141 gcaaagcttt ctgattcttc accctcgcct gctcccgctg gaagcttgcc gatcgaggtg 2875201 acctttcctt tccactcgcc ctcaccgcct gttttcagcg tgaccctgac tttgctgcct 2875261 tttttgatcg tgtccattaa cagctcattg atttggcttt tgaccagata tttgcctgtc 2875321 gaaacaatct ggatatacgg gcctgctgcc tggtcgcctg ttgcaccgtc agcgatatcc 2875381 tgattgacgc tttgaacgat tccgtcatgc ttgcttgtaa tgacattgga acctttgttt 2875441 ttcgtcaggc cagccagttc tttttgatgc tgcttcagtt caagctggct tgttttcaaa 2875501 tcgaaattgg tttgatcaag ttcatcttga agctggtttt tctcttcttt tcctgcaact 2875561 ttcagctttt tttccgtttc cgttattgat ttttgcaaac ggttgatttg cagatttgtc 2875621 atttcaattt gcaaattggc ttgctccact tcatcagaat gatcctcgcc ctcatactca 2875681 aaaagcttat cgcccttttt aacctgatcg ccttctttga cgtatgtttt tttaatgctg 2875741 cctttttctg aatctatgta tactttctgc tgtttctcag gttcaacctt tccagaaaac 2875801 gtttggcctg attctgaatc tcctcccatg tataccgcga ccgattcagc atagggctcc 2875861 gatgatacgg caacttggtt catgtgagta aaaaagtaaa aaccgccagc gccgatccca 2875921 gccaatacaa gcacaccggc acatatcgca ccgccaataa gccatttttt cttcttggac 2875981 acaacgatct cctctttctg taaactatgt aatattttcg aaacattcta accaatatta 2876041 tctattaatt caaaaagact tgcaatcctt ttattgaaat gacggaatca aatagaaaaa 2876101 ttgtattttc aaagccgaat aaaaaaaatc ccggcttcaa accgggattt tttcatacag 2876161 taactagctc tttttcattt ttaatcaagt catatgtcaa gcatacaggt ttatttgtac 2876221 ggggatcagt cacgatttcg gcatcaatct gaaatacctg cttcaaaatg tctggtgtca 2876281 tgacctccag agcagttcct tccttgatga ccgtgccttt tttgagcgcg atcatataat 2876341 gagaaaaacg agctgcatgg ttaagatcat gaatgaccat taaaatcgtc cgcccttgct 2876401 ctttgttgag tctgtcaagc agctgcagaa tttcaagctg atgtgcaaga tcaagatacg 2876461 ttgtaggttc atccagcaga agcagttccg tcccttgcgc aagcgccatg gcaatccaca 2876521 cacgttgacg ctgtccgcct gacaatgcct caatcggccg ttcagcatat tcagccatgc 2876581 ctgtttcttc aagcgcccat ttgataatcc ggcggtcttc gtcatttaat ctgccgaatc 2876641 ctgattgatg cggaaacctg ccgtacgaca ccaattcgtg cactgttagg ccgctcggcg 2876701 cttcaggtgt ctgtggaaga atcgccatat cttttgcaat gtcctttgta gacattttat 2876761 gaatcgcttt gccgtttaaa tagacggcac ctgcatgtga acgcataatt ctggacattg 2876821 tttttaaaat cgttgatttc ccgcagccgt tcgggccaat taaggtggta attttccctt 2876881 taggaatcga tatatttaaa tcctctacaa tcaccctgtc gccataaccg attccaagct 2876941 gttccgttga taatgaattc atattcggcc ccctcctcta attcgctttc atcaataaat 2877001 aaataaagta aggcgcacct agcacggaaa tgacaagtcc gaccggaatt tctgatggtg 2877061 ccaatacatt tctcgccagc gtatcagcaa gcaaaaacag gaatgagccg atgaaggcgg 2877121 agaccggtat cagcgtctgg tgacgtggac cggtcagcct tctagccaca tgcggcgcga 2877181 tcaatccgag aaacgcaatg ccccccgcag ctgccacgca tgaagcggca agagtgaccg 2877241 ctgccagaag aagaatccgt ctttcctttt caacagcggt gcccagcccg gtcgccaatt 2877301 ggtctccgag ctgcataatg ttcaaatagc gtgccttata taaagtaaac agaagcaaga 2877361 tcacaatcca agggagaatc gcccagatca tattccagtt cgccccccat attgagccgg 2877421 atatccaaac cgcggcttgc ataaaatcat gagggtccat cttgagctga aaaatcagca 2877481 acagggcgtt gaatccggca ttcaccccta tgccgactaa aatcagccga atcggtgtca 2877541 cgcctttttt ccatgccaga atataaatga gaaacgcagc gaggattgct cctgccaaag 2877601 cactgaacgg cagcataaat gttccgaaaa agctaagatc tgaagctgac ccttgaaaaa 2877661 agtatataaa aagcactaca gcaagtgaac cgccggcgtt aattccgaga ataccaggct 2877721 cggcaagttc attttgagac acgctttgca aaatggctcc agctacggag atccctgctc 2877781 caacaagcaa agaaaggatg atccggggca gcctgaactc aaataagaca agttcatcac 2877841 gcgccgttcc ttggccgaaa aagacctgaa gcgttttaag cggtgcaatt ttgataacgc 2877901 ccaaattgag actgataaaa aagaccacca cgataagcaa aaaggtcaca gccattacaa 2877961 tgagcggttt gtttgttttt gttttcatta cagccctctc ctttcacgac gtgccaaata 2878021 aaagaaaaag ggaacgccga taagagaagt cagcgcgccg acaggcgttt caaagggcgc 2878081 atttacgagt ctggccgcta tgtcagcaaa aacaagcaaa acagcaccga gcaccgccga 2878141 gcaaggaatg atccaccgat aatccacacc gaccaaaaaa cgggtaatat gcggaatgat 2878201 cagcccgata aatgcaatgg tgccggcaat ggaaaccgca gctccggtca gaattactac 2878261 aataagcatg ccaaccagtt tcaccgctga tgtatattgt ccaagccctt ttgccagatc 2878321 gtcaccgaga cttaacactg taacagaccg ggcgatgaaa aacgcgagcg ttaaaccgac 2878381 agcccctgca ataagcaaaa gctggacccc cgaccatttc acacccgcta ccccgcctgc 2878441 gtaccaaaag ctgatatcct gagcgacatc aaagcggatt gcaatggcag ttgaaatgcc 2878501 ggtaaagaaa taagtaactg ccgtacccgc cagagcaagc tttacaggcg taagtccgcc 2878561 ccttgaaaac atgcctatgc ccattaccgt cgatgccccc agccccgctc ccgcaaagga 2878621 ccatagcaca agccccattg cagaaagtcc gggaaaaaag gcaaacgcaa tcgaaaccgc 2878681 aaacgcagag cctgatgtca cacccataat cgaaggctct gccaaagggt ttctcgtcat 2878741 cccctgcatg attgctcccg acactgccaa caatgcgcct acaagcgcgg cagccgccgt 2878801 tctcggaagc cgaagatcat gtataatttg gtgagatgtc tttgtcggct gataatgaaa 2878861 aatggcctcc catacagtgc gcaaatgaat atccgctgca cctagggata tggataaaaa 2878921 tgcgccaagg caaagcaggc atagacctgc gataaggacg atgaccgcgc catatgtcct 2878981 tgacgtccat tggatttctt ctgatgcagt ccgtatattt ttatgttgac tcaactgccg 2879041 tacttccttt ctgttactga taatgattat caattgctgt ttcagtatat cacttttttc 2879101 agctgattta atagagtgtt ttgaacaaaa atgaaaatgc atttgcaaaa atatcgtgtc 2879161 aaccggcact tgcagtggta taatcacaga tgataatgat tctctttttc atctatcttt 2879221 tagaaagaag gtatgagata tgacccatat atacaagaaa ctcggagccg cgttttttgc 2879281 cctgttattg attgcagcgc tggcagcctg cgggaataac tcagaaagca aaggttctgc 2879341 ctctgattca aaaggcgcag aaacctttac atacaaggct gaaaacggaa atgtaaaaat 2879401 cccgaagcat cctaaacggg tggttgtcat ggcagacggc tattacggct acttcaaaac 2879461 actcggcatc aacgttgtag gtgcgcctga gaatgtattt aaaaaccctt actacaaagg 2879521 aaaaaccaac ggcgtcgaaa acatcggaga cggcacttcg gttgaaaagg tcattgattt 2879581 gaaccctgac ctgattatcg tctggacaac acagggcgct gatattaaaa agcttgaaaa 2879641 aattgcgccg actgtcgcag taaaatacga taagctcgac aacatcgaac agctgaaaga 2879701 atttgcaaaa atgacgggaa ctgaagataa agctgaaaaa tggctggcca agtgggataa 2879761 aaaagttgcg gccgctaaaa caaaaatcaa aaaagcggtc ggtgacaaaa ccatttccat 2879821 tatgcaaacg aacggaaaag acatttacgt atttggtaaa gactttggaa gaggcggaag 2879881 catcatttac aaagacctcg gcctgcaggc tacaaagctg acaaaagaaa aagccattga 2879941 ccaggggcca ggttatacaa gtatttcatt agagaagctc cctgacttcg ccggagatta 2880001 cattttcgcg ggcccatggc aatcaggcgg tgatgatggc ggcgtttttg aaagctccat 2880061 ttggaagaac ctgaatgccg ttaaaaatgg ccatgtatac aagatggatc cgatcggatt 2880121 ctatttcaca gacccgattt cattagaagg acaactggag tttattacgg aaagcttgac 2880181 taaataaaca aaagagccgc ctgcccgcgg ctcttttgct tatttataag gaacggctca 2880241 atttgaatca tatcggatat tttctttgag ccattcatat taagctgcat cctcatcacg 2880301 atcagttttt ttatgctgga gagactgaaa aacgtttttt gcatatttaa cgaacggatt 2880361 cctaacagga gaaattgtga ttttataaaa aagacacctg agcaaatcag gtgtcttttc 2880421 attatgcttg tttttctttc tggaacttgt tactcacaaa tggataaacg attaagccga 2880481 caaagaataa accgatgccg agtataaatg tcgttaaatc tgctgtgcct gttacgataa 2880541 caaacacgga gtatgcacac gccagtatcg cgatcaatcc gtctcttaca cgggagcctt 2880601 tcagctggtc atacgtttca cctttgatga ctaccttcaa gctgtagatt gcagatacca 2880661 gatacggaat taaatatgcg agtgtagccg ctgtcgttaa aaatgtaaat gcgtcactta 2880721 ttgtccggga aataaccgag aaaatgaaga cctgtgacat gacgtttgta ataatgagtg 2880781 caatgaccgg acttcccttt ttattcgttt ttgcaaaaaa tgccgggaaa tctcctgctt 2880841 tagcggcttg gtatggcacc tcagagccaa gcaaaatcca gccgagcatc gttccgaata 2880901 aacaaaggat agccaaaagc gccataatca cgcttcccgc gtttccaaca atcgcataga 2880961 gtacatcaac aaatggtttt tcagagccga caagcttatc atgcggcaga acacccatcg 2881021 taattaaagt cacaataata tatatgctca aggcaatcag caagccggta attgtcgcac 2881081 gtttcacatc acgctgagag cgcgcacggc cggacaggat caccgcggat tcaattccga 2881141 caaacgccca cagtgtagaa atcgcagcgt tatgaacctg gccaccaatt ccaatgcttg 2881201 tgccgttttc tccttgaacc gggaaataaa aatgaccgaa taatgacgtt tgaaacacaa 2881261 acaaaccggc aacgataaag aagacaaaac ctaatacttt agaaagcgtt gtgacaaagt 2881321 ttaatttact tgcgccgtta atgctggcaa caagaatcgc gtgcgttccc cataacaaga 2881381 tcgtacatac ggcaaacgtc agtaattggc cgagtgtcac ctcttgcccg ccgatcgaaa 2881441 acatctcacg tttatcaacc aagatcggga agaacgaagt caagtaaccg gcgagacttg 2881501 tgatgatcgc cacgttactg atccagctcg ccacccagta gccccacacc attgtgaaac 2881561 cggcagcgtt gccttttttc gggtcagaaa acagcgctct tgcataactt tgcggtcccg 2881621 ctgtcagttc aggcttgcga atggacaagt gtccgaacac aagtgcaatc atcagcacgc 2881681 cggcacctgt caaaagccag gcggacgtag ctccaaacgg actcgcaatt gaagcaagcg 2881741 agctcggcaa ggagaaaatt cctgatccaa ccatatttcc aacgacaaac gccgttaata 2881801 accaaaaacc ccattttttt gtctgttcca ttccagtacc tccatgattc tttgtacgga 2881861 ccagaccccg agatcatata aacgcaaaaa aagcctgaac aaaagtccat gcttaaagaa 2881921 acacacaccc ttgatctccg gatagccctc cgcgaaaaag cacgcggcag tcctgcactt 2881981 attcagatac agtcccagca tagagaagga tcggctttct ccacacttcg gcgctgatgc 2882041 cttttacaca tgtttaacag cccctgtcag cctagcatgt gtgactcatc atccgcgcaa 2882101 cctctacctc actgagaaag agtgaggatt taattattca gttactccca gaaggttatc 2882161 aaagaaagga tgatctgtca aagggaacag atggaaaata cggatagagc caagccctat 2882221 ccgcatgtgg ttatcgatta tttttctttt tttgcacagc ttcttgaagc ggatcatctt 2882281 ttagagctga accagcatct tcaagagctc cttggattac gtttttttct ttttcggaac 2882341 gttttccttt atctttatta aagaaaccca ttcgtatcac ctcttttaaa aaataggtac 2882401 atgtttaaga tgcctttttc ctgaaaaatt atgcgggata ttttttatcg tccaaagtcc 2882461 tgttgatcaa acatacattc tcttgatata tttgtaattc agagattttt tgcaaaagat 2882521 aaaaggagaa gcggcaaatg acaggaaaaa cacacatcat gggaggcatc gcttcttgta 2882581 cggcagcggc ttattattat ggatttgatc cagtgcttat ggctgcgtca ggcgcggttg 2882641 gagcattaat acccgatatc tgccacacac aaagcaaaat cgggagaaaa tttcctattt 2882701 tatcgaaagt ggtcagctcc gtttttggcc atcgcacctt tacacacagc ctgctgttta 2882761 tgctcatcat gttttttatc acttctacat acattccaga taaaaacata tcagccggcc 2882821 tgatgatcgg aatggcgagc cacttgattc ttgacgcttg gacggtgaac ggaatcaaat 2882881 tattattccc ttccacgatc cgcgttcggc ttccattata tatgaagaca ggcagttttt 2882941 ctgagcagct cgtgctagcc ggcctgaccc ttgcttcatg ttactacttt tatatgctgt 2883001 ttcatggccg catgttttaa acatgagtgc tgagacttgt ctgaaccggc tgtttttagt 2883061 aggttttact taagaagcat ttcatgcaga tgatcaagaa aacgtgagga gtcatattga 2883121 tgaaaggaac cttttttcac aatcagcggt ttttatgttt ttcgatctta tttatgtgga 2883181 tcaaaacgta tgtgatatat aaactcggct ttgatttgca aatcgatact ctgttggagg 2883241 agctaatgct gctggtcaac ccgctcagct ttattcttcc tttattcggg atcggcctgt 2883301 ttctaaaaga aaacaagcag cgggcctttt tgctgattgc caatttggtt ctgactgtta 2883361 tcttgatctc taatacgatt ttttacggct tttatatcga ttttattacc atcccggttt 2883421 tatttcaggc cagcaacatg agcgatatgg gcagcagtgt aaaagaactg ttccatcctc 2883481 tgtttatcgc cctgtttgtg gatttggttt ttctgctgtt gttcgccaga aaaaccaaac 2883541 acccacagac aaaagccgct ccccacacga tcaaacggta ctatgcagct tcctgcggaa 2883601 tgcttttatg cacactggca cttgcagaag tacagcagcc gaagcttttg gcacattctt 2883661 ttgaccggga aatgctagtc aaaagcatcg gcctgtttca gttccatatt tacgatacaa 2883721 tttctcagac tgttaatatc agcgcgaaag cttttgccga tgaagacagt ataactgcca 2883781 ttaaaaacta cacagaggct gattacagca agcctgatca aagcaaattc ggtcttgcaa 2883841 aggggcgcaa tgtcatcttt gtaacacttg agtcgaccca aagctttgtt ctgaatgaaa 2883901 aagtaaatgg aaaagaaatt accccattta tgaatgatct cataaaaaaa agctattcct 2883961 ttgatcattt ctatcagcaa acagaacaag gcaaaacatc agattcagaa tttatcgtcg 2884021 ctaactcact gtatccctcc cttagcggcg ccgtcttttt cacgaaaagc gaccatcaat 2884081 ttcatacgat gtataaatcg ctgaagcagc acgattatta ttcagccgtc tttcacgcta 2884141 accataaaac attttggaac agagatgtca tgtacgatac atttggcatt gaccgctttt 2884201 ttgatgttga tgattttcat gtcactcccg ggacatcgac aagctggggc ttaaaagaca 2884261 aagaattttt agagcagtcc gccaaaaagc tgaaaagcct accgcagccg ttctacagca 2884321 gttttatcac gttaacgaat cattttccgt ttgagattga tgaaaaggat cagctgatag 2884381 atgaattcga ttcaagcagt gatctgttaa accgctatgt gaccacggtt cgctatgagg 2884441 atgaagcatt gaagcatttt atcaaaaaac tgaaggacga aggcttatac gaaaattcga 2884501 tgatcgtatt tatgggagat cattacggca tttctgaagc ccataacgag gcaatggctg 2884561 agtttttagg gaaagacgaa atcacaccgt atgacaacgt tcagctccag cgggtgccgt 2884621 ttatcataca tatcccggga atcaccgatc aacagccgga aaccatccct gatgccgggg 2884681 gacaggtcga cgtcaggccg acgctgatgc atttgctcgg cgttgagaca aaaggcgata 2884741 tccaattcgg caatgatttg ctgtcgggcg accgcacccc attcgccgtt ctgcgaaacg 2884801 gcagctttat tacgaacgat tatgtataca caaagaacac gtgctatagc caaaaaacag 2884861 gtgaagtgct ggaagatcag gatgcgtgcc tcccttacaa ggagaaagca aacgaagaac 2884921 tgtctctctc tgataaaatt ttaaatggtg acctgctcag gttttccgaa tgaaaaaatc 2884981 cctctatcaa gagggatttt ttacgtttcc aatatcacct tgccagtcag cttcgtttca 2885041 tagccgttta aatgagacag attcgccttg tagtcctcag aattcaaaat ctccttcacg 2885101 gctttgagca actgctcatt ttttttcaaa acaacgatat catattgttc gtcgatgagc 2885161 gggataaaat caacactgcc catatgtgcc gcgtgctgtg ccccgattcc cgcgtcagcc 2885221 tgtccgcttg aaacttgtga agcggcagcg taatgatcag tcacgatatc gccatatccc 2885281 actacatcag ccggattcac accaagcaag ccaagctgtt catcaaggag cacccttgcg 2885341 ccagaaccct tttccctgtt gatgatccgg atatcggctc ttttcaagtc tttccagcct 2885401 tgaatgtttt tcggattccc tttttgcaca tacagtcctg ctttgcggag aacgacattg 2885461 atgagacaaa acggttcacc tgtcaaaatc cgttttacat aaggcgcgtt atactggccc 2885521 gtttctgcat cgtacaaatg gaggctgaca atgtcacact tgccttgata catatcaatc 2885581 aggctgttta agcttccttt gtatttacgg agcggcgtct cctgaatggc attctccaaa 2885641 tgcttgctga ggatatccat cgaaatgtcc tgtccgctga tcatgacatt tggtctgccg 2885701 tccggctcag cctcctgcac ctgtttcggc gcttcttttg cagcgatggg ctgagacatt 2885761 ctcatattcg ttttatattg ctttaaatct tcttcatcca cacgcatctg ccttccgaca 2885821 cggtaagcag gcagcacgcc ttttttaatc aagtcataaa cggtcagctt tgataccttc 2885881 agcagacctg caacttcttc tatcgtatag gaagaggttt cattcatcat catcactctc 2885941 ctattttatt ataccttttc gccgaatgta aaaaaaccca cataaaccaa acataatcag 2886001 ttataattag ttatatctaa tgataagggg tgcaatcatg tttaagaagt attctatttt 2886061 catcgcagcc ttaactgctt ttctgcttgt agcaggctgt tcttcaaacc agtcttcaac 2886121 ggacagcgag aaaaaagtaa cgttaaccat ctcagctgcc gccagcgcgc aggatgcact 2886181 tgaggaaatc caaaaaaatt atgaaaaaga tcatcaacat ataaccatcc aagataacta 2886241 tggctcatcc ggcgccttgc aaaaacagat ttctcaagga gcaggagcag atctgttctt 2886301 ctcagctgct gaggataaat ttaaaaagct ggtggatgat ggagatatcg caaaaaaaga 2886361 cagcactgaa ttagtcggta atgaaattgt gctggtcgta ccgaaaaacg gagattcacc 2886421 tgtgacaagc ttcagcaatc tggctgaatc agaaaaaatc gctcttggca ctccggaatc 2886481 cgtaccggca ggagcttatg ggaaagaatc actgacaaag ctgtctttat gggacaaagt 2886541 gaaggataaa attgtgtatg gaaaagacgt tcgccaagtt ctttcttatg ttgaaaccgg 2886601 caatgtagac gcaggtgttg tttataaaac agatgcccta gtctcgaaaa aggtcaacat 2886661 tgttgacgag gcaaaagcag atacacacag cccaattgtc tatccgttag gaatcgtaaa 2886721 agatacaaaa caccgtaagg aagcgaagga attttacgaa tacctgcaat ctgatgaagc 2886781 aatgaaagta tttgagaaat atggctttac tgccgagtag cataagcgct tcagaatttt 2886841 tcacacccgt tgtgctttcc tttcaggtgg cggcagttgc cggaattgtt gtcattattc 2886901 tcggaacact tgctggagca tggatgtcac gggcatcatt tttcggaaaa acggcactcg 2886961 aaacatgttt tatgcttccg ctcgttcttc cgcctactgt tgtcggtttt attctgatcg 2887021 tcattttcgg aaagcacagc ttcatcggac aagccatcga gtggattttc cagcagcctg 2887081 tcattttcac ctggtgggcc gctgtgatcg cctcggctgt tgtagccttt ccgcttatgt 2887141 atcaatcagc caaaaccgga tttgctgaca ttgatcccga tatacaaggt gcggcaatgg 2887201 tagacggcgc tagcagatgg aaagtgttta tccatatctc cgtcccgctt gcctatcctt 2887261 cgttactgac cggaagcatc cttagccttg cgcgggcgct cggagaattt ggcgcaacac 2887321 tcatgtttgc aggaaacatc cccggtgtta cgcaaacact gccgacggcg atatatgtcg 2887381 cattggattc cggcaacaat acccttgctt gggcgtgggt cgtctgtatt gttgtcattt 2887441 cctttttgat gctgtttttc attcaacaga aaaaaacgca ctaaaaaaac tccccataac 2887501 ggggagtttt ttgattaaaa cagaagctca tcaggatttg gaccgacacg ctcatcttta 2887561 tttaatgcgt caattttgtc catgtcttct tgagacaatt cgaaatcaaa aatatcagcg 2887621 ttttcgatga tacggtgttc tttaatggat tttggaatgg ttacaactcc atgctgcaga 2887681 tcccagcgca aaatcacttg agccacagat ttattgtgtt tttcagcaat ctgtgtcagt 2887741 acttcgttat ccaaaagctg tccctgcatg agcggagacc acgcttccag ctgaatgcct 2887801 tgccctttgc agtaatctct taattctttt tgcgtcaagc gagggtgaaa ttcaacttgg 2887861 ttcaccatcg gtttgatttc agcatctttc aacagctctt ctaaatgatg aacttggaaa 2887921 ttgctgacgc cgatcgcgcg aattttgccg tctttgtaca gcttttcaag cgcgcgccat 2887981 gtatctttat atttatcttt gccaggccaa tggatcaaat ataaatctaa gtaatcaagc 2888041 tgcagtcttt ctaggctttt ttcaaaggca gcaagcgttg tttcatagcc ttgatcttca 2888101 ttccacactt ttgatgtgat gaagagctct tctcttgcca caccggattc tttaatcccg 2888161 atgccaacgc cttcttcatt tttgtagatc gctgctgtat caatactgcg atagccattt 2888221 ttaattgccg ctttcactga ttcagtcgct tcattaccat tttctacttt aaaaacgccc 2888281 agaccgaacc aaggcatttc aactccgtta tgtaacttta cagtatcttt taaacttgtt 2888341 ggcacttgaa cctccaccct ttcactgaaa tgtaagcgtc tatattatct cacattcctc 2888401 tcagccgata ccaataatac gcttaagacc ctctttttgc ttcttttttc acagcacagg 2888461 caaatccaaa cactattttt ttcctatttt aacaatattg agattacaaa tacattgagc 2888521 agggtatgcg tgtagtgtaa ccaaatgaaa acaaaggagg aaacaacttg aaacgtattc 2888581 gtatcccaat gacacttgct cttggtgccg ctttgacaat tgcccctttg tcctttgctt 2888641 ccgctgaaga aaatcctgct ccgaagatgt cgcagacaac tactgctgga acaactgccg 2888701 ctgatgtagg tttaaacgtc aacctggatg tacttggaat tgccaaccag atcgctgatg 2888761 ccatcaaatc cgcacagaat agggatggct ttgtgaaaaa cctcatggag tcttccttct 2888821 acgcgtccgg ccaaaaatat aacgtcatgg tctttaattt aagccaggaa tatgaagatc 2888881 atttgaacgg tgtgcaattt tacggctcag ccgtttacga cggcattacg tatggcattt 2888941 gggtatttga agatggaacc tttacaaaca aaggcgatgg cggctggatc aactgggcct 2889001 tcagaggctg gttcgaccgg gatggcagca ctgtcgcatt tcatcgccct taatataaaa 2889061 aaagctggcg ctctaacgcc agcttttttt ctgcatttat tcgccgcctt caagcatggc 2889121 ggcttcgaca tcattaatgt attggcgaag ctcatgggag atgtcccggg aaatttccct 2889181 ctcttcgaag agcgtttgaa tttcatttct gatcgcctgc acagccttca gcttcacttc 2889241 cagcttctga ttttcaaaat gggcacttga ttttaactca tgatggctgt gctccagcct 2889301 gaaaattaac tgcttataga atgtaatgac agataaaaac acttctttat gctcatccgt 2889361 cttatgtttt tccagatatt ctatcgctgc ttttgccgtt ttcactcttg ttgcccgtat 2889421 caatcccgct tcatttaaaa tcgacatctc cggcttttta tgttcaccga agaaaatcca 2889481 atacatcagc ctcttgagcc ttgtttttga taacccgact ttaaacgggt tggcatacaa 2889541 aatttccaac tcgttaaatc gttcttgcag cacatttgct gtttcttccg ggatgtctcc 2889601 ccgctccagc attttcatca gcgcctcttg ctcagcctta accccctgcg cacggacttt 2889661 tcgctcgtgc ttcttaatgc gattagatga tgtatactgc tgaaaacgaa gatttttcat 2889721 tttctcattg tattcagcta tcaccgcaag agaggccgtt ttgtttgtct cattcatgtc 2889781 ctctttaatc gtttgaaggg ctgttttgat caacttgcgt ctcgccgtca gcagcttctt 2889841 atttcgttcc tcgtcctctt cttctttttc agtcagaatt ggcagcacaa cggtggcaat 2889901 gacaagcgtg cataaaatga cgccggctgc taaaaagaga atcagatttc tttccggaaa 2889961 cggcgtaccg tcctccagga aatacggaat ggaaaaagaa cctgcaagcg ttactgctcc 2890021 acgcacaccg gaaatcgaaa ttaacagcgt cgaacgaaga cccggtttat agatgttctg 2890081 atctttatta aagaaccatt tgccgttcca gaagaacagc acccacagga atctaaggag 2890141 cattaatgta aatgtgatga ctaggatata gccgatcacc ttcatgttgc tgatggcagt 2890201 gtcgttaaag ataacagaaa taacatcagg gatttgcgtg ccgagaataa cgaagaccag 2890261 gccgttcaaa ataaataaaa taatgttcca cgtacttgag gagacgattt gcagcttgat 2890321 catcgttgat tccagacgat cctgttcaac cgcatgggta ataccgccag ctacaacagc 2890381 taaaatgccc gaaacgccga tttcttcagc tgccaaataa atcacaaacg gcgtcagaat 2890441 ttgaatcagc atatgcatcg tgacatcctg catgccaagg cggcgcagaa ataggcgaaa 2890501 acgaataatc aaaaatgaaa tgacaacccc gcacagcaag cctccgagag aaataaagac 2890561 aaagctgaca gccgcttgtg ctaatgaaaa tgcaccagtc actgccgctg caatcgcaaa 2890621 cttaaaggcc accagacctg atgcatcatt catcagcccc tcaccttcca gcaggcgaag 2890681 aatccctttt ggcattttca ctcttcctga taatgcgctg acagcgacga catcagtcgg 2890741 tgaaagaatg gccgcaagtc caaaggccgc tgccagcgga atagcaggaa tcatccagtg 2890801 aatcgtgtag ccgcctacaa tcacagtcgc aaatacaagg ccgagtgcaa gcaataaaat 2890861 cggagccctt aaattccaaa gctctgcccg cggtgtcctc tttccatcat taaatagcag 2890921 aggcgcgata aaaagaacaa aaaacaattc ggtgtttaat tcaaaatgaa gtccctgtgg 2890981 aaatgaggcg gcaagaatcc caagagccac ttgaatcagc ggcaccggaa taaacggaat 2891041 aaaccggttc acgatattag aaatcgcaat aatcgttaat aatacgagca caactaaaaa 2891101 tatgtccaaa tgcatgacct ccttcgtctg ttgtgtgtcg gcatgatgag ccaaaaaatc 2891161 tgtttgtcta aaagcccttg agctagggtg gccttgcatc cgctatgtgg tttcgcagga 2891221 gttctctcca cacttgtctt cttttatagt acccttttta gggtattttt tctcatgata 2891281 tgctcacagt gaactttttt gcagaagagc aaattataga aaaaagagac aggaagctac 2891341 tccctgtctc tcgtctttct ttctcaatca tgaaaattcg taccgtcagt tgttgcttta 2891401 ataatgcccg cgcgaatgac aaagtcaccg aaatgctcgc cttcctcgcg ttctttcgca 2891461 tagcgggaaa gaaggatgcg cagctcgctt aaaatgtctg cttcaccgat gttttcacgg 2891521 tacattttgc ttaaacggct tccgtcaaac gcagcgccaa gatacatatt atatttgccc 2891581 ggcgcctttc cgataaatcc gatctcaccg agtgcatgac gtgcacagcc gttcgggcat 2891641 cctgtcatgc gaatggtgat ttcctgatca cgaaggccgt tttcgtcaat aatctcttca 2891701 atcttatcta acagggtcgg caaataacgt tctgcttcag ccattgccaa tccgcaggtc 2891761 ggaagagcga cgcacgccat cgagctgcgg cgaagcgctg aatagtgctt gccgtcagtt 2891821 agtccgtact gttcaattaa agcactgatt tcttcttttt tatcgcttga aacgttcgca 2891881 atcattaagt tctgattggc tgtcagccgg aactcacctg tatgaacttt ggcgatttcc 2891941 cgcaagccag tcatcagctt ataatcatcg taatccgtta tacggccgcc ttcgacaaac 2892001 agcgtgaaat gccatttatc ctcgatgcct tccacccagc catagcggtc gccgttatga 2892061 tcgaaatgat acggcttcgc ttcttccagg ctccagccga gacggttttc caattcttct 2892121 tttacgtttt ctaaaccgag gcggtcaact gtgtatttga accgcgcatt tttacggaca 2892181 gaacggttgc cgtaatcacg ctgaatcgta atcgtttttt cagcaacgtc atacatttgc 2892241 tcaggccggc agaaaccgat caccttggct aattgcggat atgtcgcagt atcgccatgc 2892301 gtcattccca taccgccgcc gattgccacg ttaaaaccga tcagcttgcc atcctcgaca 2892361 atcgcaatga atccgagatc ttgtgaaaag acgtcaatat cattagacgg cggaacggca 2892421 ataccgattt taaacttccg cggcagatag agcggtccgt acattggctc gacttcttcc 2892481 tccggcgtgc cggcaactct ttcctcatca agccaaattt catgatatgc tctcgtccgc 2892541 ggcagcagat catcacttaa ttttttagac cactcgtata cctctgagtg gatttcagat 2892601 tgataagggt ttgatgcaca catgacgtta cggtttacgt ctccgcaggc tgcgatcgta 2892661 tccaaaagtg ctgagtggat cgtctgaatg gttttcttca tgttccattt cagaattccg 2892721 tgcatttgga atgtttcacg tgtcgtcaat tttaatgtgc cgttcccgta tttctgggac 2892781 aggtcatcca tgacaagcca ttgttcaggc gtcgagacgc cccctggcat acgcacgcgc 2892841 agcatgaact gatatgcggg ctcaagcttc tgcttttggc gttcatttcg gaggtcgcgg 2892901 tcatcctgca aataactgcc gtggtgtttc atcaggcggt tatcatcatc cggaattccc 2892961 gcactgattc gatcgagcat cacttctttc agcgtgccgc gcaaataatc actttctttt 2893021 ttaatgcgtt caacatcact tggagagccg tccggtgctt ttagaatttt ggtcaccatg 2893081 ttgaaaaact cctttcaagt caaatcaata tacatcacgc tgatagcgtt tttgctgctg 2893141 catatcggca agataagcct ccgcctcttc gcggctcata ttgccttctt tttcgataat 2893201 ttcaagcaat gtgttatgga cgtcatgcgc catgtgcttt tcatctccgc aaatgtaaac 2893261 agccgctcct tcttgaagcc attcaaacaa ttctgcgcta tgttcaagca tgcggtgctg 2893321 cacatatact ttttcttccg tatcacgtga gaacgccaca tccatttttg tcagcacacc 2893381 gtctttgagc caattctgcc actctgtctg gtaaaggaaa tccgtgacaa agtgctgatc 2893441 gccaaagaac atccatgcct ttccttccgc tcccgtctcc tcacgctcct gcataaacga 2893501 acggaaaggt gcgacgcctg tcccagggcc caccatgata atcggtgttt cagggtcttt 2893561 cggaagctta aagttttgat tgtgctgtac ataaaccggc agtgtgtctc ccggctgcag 2893621 tcgttccgcg cacaaaatcg agcagacgcc ttttcgttca cggccgtgcg catcgtagcg 2893681 gactgcgccg attgttaagt gcacttcatc cggatttgcg gataaactgc ttgcaatcga 2893741 ataaaggcgg gcaggcattt ttcgcaaaat cgagacaaac tcctgcgcag atacactaaa 2893801 tgggccatag tcacggacga gatcaagcaa atcgcgccct tcaatatagg cttttacatt 2893861 ctcctcattt cccggggcta aaagctctct aagctcatcg ttccctgtca gctgggctgc 2893921 ctgttcaaga agcggttttg tgagaacggt aatctcatag tgagaaatca gcgcttcttt 2893981 cagcggtcgg acatcacctt gcttattaag cgtcacaatt tcttccgggt cccaattcat 2894041 ttccttaagg agcagctcga caagttccgg atcgttttcc ggatagacgc cgaggctgtc 2894101 accaggctcg taagtcaggc cagatccttc aagagacagc tccacatggc gtgtttcttt 2894161 atttgatcct ctgccgttta aatttaaatt ttctaacact tcagcccgaa acgggtttgt 2894221 tctggaatac gaagactcac cggtttgtga cgcagccgcc ggcgcaggcg cggcgcttcc 2894281 gcccccagct tcatttaatc ctttcaatac accctcaagc cattcggctg ccggttcatc 2894341 atagtcaaga tcgcaatcaa cgcgcggaga aatccgtttt ccgccgagtt cttctaagcg 2894401 ttgatcaaat tctttccctg tctggcagaa aaattcgtac gaactgtcac caagcgccaa 2894461 aacggaaaag cgcaggtctt caagcttagg cgcccgtctt ccgtgcagaa attcatgaaa 2894521 cgacagcgcg ttatcaggcg gctcgccttc tccatgcgta ctgacgacga ttaaaagatt 2894581 ggttaccttc ttcagctgat tcggcttaaa atcgctcatg gatgagacgg tcacttgaaa 2894641 accgctctgt tcaagctgct tgccggcatt ttctgcaagc ccctgtgcgt ttcccgtctg 2894701 tgaaccataa agaacggtca cttcttttga aacggccggt gccggtgctt ccgctgacac 2894761 agctgccgcc ggcgtacccg cagcttcttg ggcggaaaca gattgagcgg ataaatatcc 2894821 gctcagccag attttctggg attcggtcaa ggtcggcaga aggcggttaa ggagctctgc 2894881 ctgctcctga ttaaacggac tgttcattac ctgaagttgc aacgtatcca cctcacaaag 2894941 ttataaactg atcgaaaatt gcatctaatt gaactttacc ggaatactag gcttaagtaa 2895001 aatatattta catgatgata actattaaga atcctaatga taaaacggct atgcttcatg 2895061 taaatagaaa aaagagaagg actcccttct cttcattcag caatctgata taagtgaggc 2895121 ggcacagcgg ttacaaacgg actggcttca cctgtataaa ataccgccag catgtgcatc 2895181 gcacgggtgc acgcagtata taaaagcctg cggtcgtgct ctgtatgata gtgttcttca 2895241 gatgcatcat agacaagcac tgcgtcaaat tcaattccct tcgctaaata caccggaatc 2895301 acgcaaacac ccttttgaaa tggttgattt tctttatgaa tcaggcgaac atctgtatat 2895361 tcactcatgt gggcgtgcgc ctgtatgcat tgatgcgcag tcttgcagat gacggctatt 2895421 gtttcgtgcc cttttttctt gagccggcca atttcttgcg cgagcttttg gcaaaggctc 2895481 tcatgtcctt cagttttgac aacgagcggc atttccccgc ttctattaaa cggctcaata 2895541 tccgctccat cttgaagcat cgctttggta aactcgacaa tctgccttgt tgatctgtat 2895601 gttctcttta aacgaacata ctcagcaggc tcatcctcaa agcacgcatc catacgctga 2895661 tccccgttta tggtatgcgc gtagatggac tgattgatat caccgagcac tgtcatgctg 2895721 gcagccggaa aaatgcttct catgtaagcc atctgaaacg gtgaatagtc ctgggcttcg 2895781 tcaataaata gatgtttgat tttcgtattt ttctttctgc cctcaatcag atcctgcata 2895841 taaagaaacg gtgccgcgtc ctcatagagc aatttattat ccgtaaatgc cgaacgggtc 2895901 agctcaccta tcgcatccat cttctcatgt tgaaattttc ctccccagcc agaaaacaat 2895961 tgcaaataaa gttgtgtaac atcaagaaat gcaaggagcc tgactgcctg tttgagcggt 2896021 ttgaaagctt ttttcacaat gatggcggca agcagctgct gctctctttg ataatcgtta 2896081 aacgtactct cgctgaaccg tttcctttcc tgcagttttt tgtacacgtc caagtagtcc 2896141 tctttgtcaa gcagctcagc ttcatgaaca acccaatcct ttcgccgttc ctttttctca 2896201 agcttgttaa gctcactcag cagccacttc gcggtttgct ccatccgatt cggaatggag 2896261 tgattttgat ccaatgagta aaaataggat tgaatttgct cctttgtgat cagcttttgt 2896321 ccgcggaata taatattttt aaaaatcatc ccttcagagg aaagccgtgt gacgtattca 2896381 ttaatgaatt gctgaaagga taaacccgcc ttccatgtga ttcctgcaag ccttgttgga 2896441 aaatcgcctc cctttgtttc ggtcaggcaa tattcgagct gatcaaaggg gctttcacat 2896501 ttgaacttgc ggccaagacg atgctcgata tattcctgaa acgtcgcctg ctccatattc 2896561 tcttctccta actccggcaa aacagaggag acatagctgt taaataagaa gttgggtgaa 2896621 aacaaaacga tttgtccggc atcaatgaca ccgcggtgcc tgtataacaa ataagcgaca 2896681 cgctgaagcg cagccgatgt tttcccgctg ccagccgctc cctgcacgat caggatcttg 2896741 cttttttcat tacggataat ctgattttgt tctttctgaa tcgtagacac gatgtttttc 2896801 atttgggtat cagagtgatg gcttaatacc tcttgcagca tttcatcgcc aatcgtcata 2896861 tcggtattaa acatcgcctt gagagtgccg tttttgatca taaactggcg tttcagcacc 2896921 atttcccctt ctatcgtttc accgggcacc tcgtactccg cttttcctgg ggaataattg 2896981 tagtacaaac ttgatatcgg cgccctccag tcatagatca gaaagtgttc ctccttctca 2897041 tccaaacagg aagctaaacc gatataaatt cgctctgcct gctcctcgcc gttttcaata 2897101 aaatcaatcc ggccgaaata aggcgatttt ttcaattgat gaattcgttt gagctgctga 2897161 tccatgcgcc gatgattgtg ttcccgatca gacagcagct ctgcctgctg cttaatgcta 2897221 gccatcgttt caatcgcttc atgggcatca tcaaaattaa ccttaacatc ctcccaaaag 2897281 ctttttctta atccgatgat atcatgcttc aacccgcccg cagacgtttc cagaaaccgc 2897341 tctttttttt cgagctcctt cagcacctca tctattctcg actgctcttc cttccattcc 2897401 ttatcctgct gattcatgaa cggcacctcc agaaaatagt tgacaaacat agatgaaata 2897461 ctgtaaaata taattggata catatattaa atatatgatg caaactggca aatacaattt 2897521 ataatagcac attcacccaa taccaatcaa ggtttgggtt atttatatta tgcagaaaaa 2897581 aaccgatttc acttcgaaat cggttttttt gctattaatt atctaagcga aaagaacggt 2897641 ttggcagctt ccaattaaac atataggaac aaacccggca aacaacgagc acgaaaaaca 2897701 gaacgtataa gccgaacgag ttccccagcc agcccaagcc gacgattaaa ccgccgagcg 2897761 ccgcccatac cgcatagatt tccgctttca gcacaagcgg tttgcgcccg gcaagaaggt 2897821 cgcggatgat cccgcccccg cttcccgtca gcaccgcagc cacgatcacg gcactaagcg 2897881 gatggcccat tttgacggca tacagtgcgc cttggatagc aaaggcagcg aggccgatcg 2897941 catctgataa attgccccac ttattccaat gcttcagcag cagcttcgga aacagaaaca 2898001 caattgtaat agataaaagc gcgatttgaa agtacgctcc ctgctcccat agcgctgaca 2898061 ccggaacacc gatcagcaaa ttgcggatcg ctcctcctcc aaaagctgtg acaatcccta 2898121 atatataaac tcctaaaata tcatattcct cttccatcgc aacaattgcg ccgctgactg 2898181 caaacgcaat gatgccaatc acactaagca gctcccaagc cattctgatg actccctttt 2898241 atgtttgtta aattttctga cgacctctag attttataat cgctccagcg taaaatcaat 2898301 aacattttca tgagaaaaaa agataaattt agagggaata cggctattgc tgatggacat 2898361 gagtttgcga aattaaaaaa gcgcccggca tacgcgggcg ctttttttgt tattcagatt 2898421 tttcgccttt cagcaggcac ataaaaatga taatcaggat aaaagcaatc agggccagga 2898481 atggaatcgt aataaaacca aaccagttaa tatattggcc cgagcacggc acgccgctga 2898541 cacatggctt aatgccgcta aagccgggca ctttttgctc taagtaatgc atgatcgaaa 2898601 tgaatgcccc aataatcgcc atcgggagca catatttttt cactcgtgtg tccccttgaa 2898661 aggtggcgat gcctaaaatc aggacgagcg gatacatgag gatacgctgg taccagcaca 2898721 gttcacatgg aataaacttt ctgatttcac tgaaatacag gctgcccagc atagcgataa 2898781 gagccacaac ccaggaagca tataaaaata cgattctatt tttcatattg ttacttccct 2898841 ttcagctctt tttctattgt ctctttgatt tcatcataat ccgcaaaatt tttgatcact 2898901 ttatcattga cgtaaatcgt cggtgttgcc tgtatgttca ttttttgatt aaggtcagaa 2898961 tccttttcca cttgagaagc gaatgtttcc ttatcaagat tttccttgag cgtctcaggt 2899021 tttatctttg tggtgctttt tgcaagatca ccaaggaggc ctggggttac ccattcctgt 2899081 tccgtatccg gctgtttttc gaacagcttt tcatggaaat cccagaaaga gtcagggtct 2899141 tccttccata cttcttcaga tgcaagagcc gctaaccttg aaccttttcc atggaacatg 2899201 acgttcacga aagaaaattt cacatcgccc ttatcaataa agtctttttg tatttttgga 2899261 aagatgtcac tgttaaacac cttgcaagac ggacatttgt aatctccgaa ttctactaca 2899321 gttaccggtg catcgtcctt gccaagcaca ggctgccctt tgatagacgg ctgtccggac 2899381 accgcatcat tgccttgttc cgttttgtta ttaatgatga caatggctgc tagcaataca 2899441 acaaccacaa ccgtaaggat gaccgcgaat ttcgcagaag actgctgttt ctttttcact 2899501 ccgacacctc atcgttttaa aattaaaaaa gaagcggatc gcaattgacc cacttcttta 2899561 ttttaacaag acaagcgctg ataagaaaac cccgaaaaaa tgaattctct ccgacaattt 2899621 atttgttttt gagacgcatg acgcgcatgg cgttcgccac agcaagcagt gtaacgccga 2899681 catctgagaa aaccgcttcc cacatggtcg caattccaaa tgcaccaaga atgagaaaga 2899741 tcgctttcac acctaaagca aagccgatgt tttgccacac gattcgccgt gtccgtttcg 2899801 caatccgaat cgcttctgct atttttgacg gctgatctgt catcagcacg atgtctgcgg 2899861 cttctaccgc ggcgtctgag ccaaggcctc ccatcgcaac ccctatatct gcgcgtgcaa 2899921 gcaccggcgt atcattgatg ccgtcaccga caaaaatgag tttttcacta ggcaaaagct 2899981 tagcttctaa tgcttcgacc tgcgcgactt tatcttgcgg cagcagctct gcatatacct 2900041 caccaatccc aagctgtttt ccgacggctt ctcccgtttg tttcgaatca cccgtcagca 2900101 tagctgtctg tttgatccca agcgacttca gatcagcaac cgcctgtgct gcgtcttcct 2900161 ttatctcatc cgctatgatg attgctccgg catagcgttg atctacagca acgtgtacga 2900221 ttgttccagc attttcatcc gggacatcct caatttgttc tctttccatg agctttttat 2900281 tcccagcaag gatctcagtt ccatttacct ttgcaaaaat gccgtgaccg gagatttctt 2900341 cgtatgactc aatctcatcg gaggaaagca ttttcccgta agctttacgc acagattcag 2900401 caatcggatg ctgtgaatga agctcagcgt atgccgccgc ttcaagtaat ctatcctttg 2900461 taaaaccttc cgcgggtttg atttctgtca cttcaaagct gccttttgtt agtgttcccg 2900521 ttttatcaaa caccgcgtat ttgacttgat tcaaagcttc taaataattg cttcccttta 2900581 caagcactcc ggcctttgag gccgctccga ttccaccgaa gaaaccgagc ggaatagaga 2900641 caacaagcgc acaaggacaa gaaatcacta aaaagataag cgcgcggtac acccaatcgg 2900701 aaagcgcggc gccagaaaga acaagcggcg gaacaaaggc cagcaatacc gcaatgatca 2900761 ccacagcagg tgtataatac ttggcaaact tcgtgataaa gttttctgtc cgggctttac 2900821 ggctgctcgc attctgaacc aagtctaata tttttgatac tgctgattcc tgatagccct 2900881 ttgtgacttc aatatgcaga acgccgtttt gattgataaa gcctgacatt acatcttgtc 2900941 cttccgcagc ttttctcgga acggactcac ctgttaaagc agatgtatca accatcgctg 2901001 acccttgcac gaccttaccg tccaggggta tgctttctcc cggattaacc acaatgatgt 2901061 ctcctgtctg aacgtcctcc gacgaaacct gttcgatgcc gttctttgtt ttgagattgg 2901121 cgtaatcagg ccgtatgtcc attaacgcac taattgattt tctggaacgg ctgaccgcgg 2901181 ctccttgaaa aagctcaccg atttgataaa acagcataac ggcgaccccc tcagggtatt 2901241 gctgaatcag aaaagcgccg attgtggcaa gagccattaa gaaatgctca tcaaacacct 2901301 gaccgcggat gatgtttttg actgcgcgga ttataatgtc accgccgata atcaaataag 2901361 caccgaggaa aaggaaaaat tcaatggttc ccgactgaac caaatatgcc gctgcgccga 2901421 gaatgacagc cgccgccatt ctgatcagca tattgaccat tcgattacga tagccatcat 2901481 cagctgattt ctttatatgc ttttggcgaa ccgttacatg cggatcaatt gatttcactt 2901541 ttttctctac tttattcgtg acccattgct cttctttccc atcggctgag acagttaagg 2901601 tgcttgccgc aaaatttacc gcgcatccgt taatgccttt tatgcctttg actccatttt 2901661 cgatttttcg ggcacaattg ctgcaatcca aaccgtccag aacatattcc tgtttcacta 2901721 gtctcacctt accttccgat ttagggttcc ctcttcaaag cgtatcaatg agtattgtat 2901781 ttattttata tatatgagca tatactcata tataagttac acctattata tgttgttttc 2901841 caagaaagtg tcaatgaaaa acaaaaaccg gcatatagcc ggtttttcat tttacttttt 2901901 gcagacgaag agcattcaga acaacggaaa cggagctgaa tgccattgct gctcctgcta 2901961 tccacggtgc taaaaatcca agtgctgcga ttgggatgcc gaggctgtta tagccaagcg 2902021 cccagaataa gttttgttta atgtttttca ttgtcaatct gctcatgcgg attgcgtcgg 2902081 caatgctgtt cagatcgccg cgaataagtg taatgtctgc tgtttccatg gcaatgtccg 2902141 tgccagttcc aatcgccatg ccgatgtcag ctgtggcaag cgccggcgca tcgttaattc 2902201 cgtcgcctac cattgctgtc tggcggcctt ctttttgcaa gcgggcgatt tccgccgcct 2902261 tttgttcagg aagaacttcc gcaatgatat tcgcaattcc cgcttccttc gcgatggctt 2902321 ctgcggttct gcgattgtct cctgtcatca tgatgacatc aagacccaac tctttcagac 2902381 gggcaacagc cttccgcgac gtatccttaa tcgtatctgc aactgctact agccccgctg 2902441 cttctccatc aatggataca agcataactg ttttcccttc ggcctctagc tcttccattt 2902501 gggcgagaag agccccatgc tcaacctgtt cgctctccat taattttctt gtgccgacga 2902561 gaatgctttt tcctccggct tcagccaaaa tgcctgcgcc gacttttgct tcaaagcggg 2902621 taagtttcgg tatctcaagc cctttatctt tcacgccagc aataatcgct tcgccaagcg 2902681 gatgctctga tcccgtttcc gctgccgctg caaattgaag caaatctttt tcttcaaaac 2902741 ggccgaatgg aatggcatcc gtcagacgcg gcttcccgtt tgtcacggtt ccggttttat 2902801 caagaacaat tgtatcgaga cgatgtgttt tttctaaatg ctcgccgcct ttaaataaaa 2902861 tcccgaattc agcagcgcgt ccagatccag ccattatgct cgtcggagtg gcaagaccga 2902921 gggcgcaagg acaggcaatg acaagaaccg caatgaactt gctgatcgct tcggcaaaat 2902981 cgccaggagc cgcccaaaga taccaaatga gaaaagtgag aaccgcaatc cccaatacaa 2903041 tgggtacaaa aatgcctgaa atctggtcag cgagacgctg gatcggcgct tttgaccctt 2903101 gtgcttcctc aacaattttg atgatatgag aaagcgcagt atcctttccg acgttgacag 2903161 ctttaatttt cagaaagccg tttgcgttaa cggttgaacc tgtcacgctg tcaccaggat 2903221 ttttgtcaac aggaagactt tctcctgtaa tcatcgattc gtcaaccgct gaacggcctt 2903281 caaccacttc tccgtcgaca ggaattcgtt cgccaggttt gacgtaaaca atgtcattaa 2903341 caagcacttc gtcgatcggg atgatttgct cctgtccgtc tcttacaaca gtagctgttt 2903401 tcgcttgaag cttcatcagc tttttaatcg catccgagga acggcctttt gcttttgttt 2903461 caaacaactt gcctaataaa atcagcgtca gcaaaatcgc gcttgtttca taataaaggc 2903521 cgtctgtatg cccgtgagag ccaatgcttt gaaaagttag ataaagacta taagcgtaag 2903581 cagccgtcgt accgagggcg accaatacat ccatattggc gcttttattt ctaagcgcct 2903641 tatacgcacc cacataaaac ggccagccga tcagaaactg gactggtgtc gccagcgcaa 2903701 actgcatcca cggattgaga aatatatccg gtacccaaat gaatgatgta aatgtaaaat 2903761 ggctcaccat cgcccaaagc aatggaaatg acaggacagc tgaaaaaatc agtctcgccg 2903821 tttgcttccg ttcttctttc tttttagcag cagcctcact gtcctgttca cccttcaact 2903881 ttagcttata tccaagctta tctaccgctt ctttcaaatc gctgacagac gcttcttttg 2903941 gattgtattc gaccgtaact gtttctaaag cgaagtttac tggtgcattt gcgacgcctt 2904001 ctattttgtt aagccgtttt tcaatccgat tggcgcaagc cgcacaggtc atgccctcaa 2904061 tatcgaattc agctttttct gtaacgacgt gatagcccag cttctctatt ttttcctgaa 2904121 tcgctgcagt ccctgtttca gcaggatcgt agattacatt tgatgtttcc gttgccagat 2904181 taacatttgc atccgtgaca ccgggcatcc gcttcaggcc tttttcaatt ctggcagcac 2904241 atgccgcaca ggtcatacca gagacctgca tcgcgatttc cttttgttca ctcaacatac 2904301 tcactccttt atatacacct ggggggtata taaaaatgaa agaaatatcg cgcctcccta 2904361 aaggcgcgat accttgaatc acttggctac gtcatagccc tgatcttcta tcgcatccgc 2904421 aatatctttg actgatactt tgtcagcatc aaacgaaaca tcgactttac ccgcttccag 2904481 attgacatga acggcactga cgccgtccag ttctcctacg cttgtttcta ctgctttgac 2904541 gcagtgctga caagacattc cttcaacttg caatgttttt tgttccatat caattcctcc 2904601 tgtttattct ttctattttc atcctaccat acccccgtag ggtattacaa taaaaaacgc 2904661 tttatgattt tgtgaacttt ttaaatacgt ccaaaagctc agaaatggcc tgttccccgt 2904721 ctccgctttt gatggcatct gctacacaat gatgggcatg atcctcaagc aaatgaagcg 2904781 ccacattttt cattgccgcc tgaacagctg aaatttgcac aagaatatct acacaatatc 2904841 tgtcgttttc caccatgttt tgaatgcctc tgacctggcc ctcaatccgc ttaagccggt 2904901 ttgtaatctg atccttttct ttcgagcttt tatggtttaa tgttttatgt tcgttatgct 2904961 tttccatgcg tacacctctg tttaatgata ttaattccca ttatactgat tgtccaaacg 2905021 gttgtctaag catgccgacg caaaaaatga atcagttagg ttttaccatt tgatcaggag 2905081 ggtatatact tctgttgata acgcttttaa aggggagaag aaaagtggat acgatcaagg 2905141 ttggaatatt aggatacgga ttgtccggtt ctgtttttca cgggccgctg ctggatgttc 2905201 tggatgaata tcaaatcagc aaaatcatga catcacggac agaagaagtg aaacgggatt 2905261 ttccagatgc tgaggttgta catgagcttg aagaaatcac aaatgaccct gccattgagc 2905321 ttgtcattgt caccaccccg agcggccttc attacgagca tactatggca tgcatacagg 2905381 ccggaaaaca tgttgtgatg gaaaaaccaa tgacagcaac ggccgaagag ggggaaacat 2905441 taaaaagggc tgccgatgaa aaaggcgtat tattaagcgt atatcataac cgacgctggg 2905501 ataacgattt tttaacgatt aaaaagctga tctctgaggg atcccttgaa gatatcaata 2905561 catatcaagt ttcctataac cgctacagac ctgaagttca agcgcggtgg cgggaaaaag 2905621 aaggcactgc cactggtacg ctgtatgatc tcggctccca catcatagac caaaccctgc 2905681 atttgtttgg gatgcctaaa gccgtgactg caaacgtgat ggcccagcgg gaaaatgccg 2905741 aaacggttga ctattttcat ttaaccctgg attatggcaa gcttcaagcc attctatacg 2905801 gaggatcaat cgttccggca aacggacctc gttatcaaat ccatggaaaa gattctagct 2905861 ttatcaaata tggaattgac ggacaggaag acgcactcag agcgggaaga aaaccagagg 2905921 atgacagctg gggtgcggat gttccggagt tttacggaaa gcttacaacc attcgtggct 2905981 ccgacaaaaa aacagaaacg attccatcag taaatggctc ctaccttact tattaccgta 2906041 aaatagcgga aagcatacga gaaggtgctg cgctgccagt cactgctgag gaaggtatta 2906101 atgtcatccg catcattgaa gccgcgatgg aaagcagtaa agagaaacga accattatgc 2906161 tggagcacta aaacaaaagc ctccccaaat aaggggaggc tttttcatta gaatgttttt 2906221 cctgcttctt tcgcacgcgc aatcgcgtct tctttgattt gctgtgcttt atcaggctcc 2906281 gcattatgtc cctctacgaa aatgccatcg aatgatggta cgccgaagaa gttcatcatg 2906341 atgccgatgt agcggtgccc catttccatc tcagccgcag ggccttctga atagtagccg 2906401 ccgcgcgctt ggatatgaat tgctttttta tcagttaaca agccgacagg accttgttct 2906461 gtgtatttga atgattttcc tgcaacagca acagaatcga gatacgcttt catcactggc 2906521 gggaatgaga agttccataa aggagtaaca aatacgtact tatcagctga tgcaaattga 2906581 tcgctaagct ctcccaaacg gcctactttc gctttttcgc tttcagaaag ctcttcaaag 2906641 cctgtacctg actgaagctt tccccatccg ctaaatacat ctgcgtcaat gtgcggaatg 2906701 ttttctttgt acaaatcgat atgtacaact tcatcatttg gattcgcttc tttgtaagat 2906761 tcgataaatg ctttacctgt tgccatactg tacgaagttg cttcgtcatg tggatgagca 2906821 gtgatatata atacttttgc catttttacc agccctttcg tttttaaaaa tcacacatca 2906881 attattatca tacagatgca taatgattat tctgtctctc ttagacttta ttatagagac 2906941 aaagaaattt actttcaagt aaaacatctc gaattaaaga ttatttaact ttcccaaaca 2907001 gcttactttt caaaagctgt tctcaagccg gaatacagcg cggacaattc tttactgatc 2907061 cgaggataat gagggacatg cggcacttga atatccgcag gcatcctttt catgataaag 2907121 gattgctcag cctgttcaaa aaacgcccgc agctggttga tctcttcatc agaaaacgga 2907181 gcagacggac ggcggtgagc ttgcgccgag agcaaatagt accctaagtg ctgagcaccg 2907241 gaaatggcag gccagagcgc atccgcattc gcgtgaggaa actcgccaag cgccttgtca 2907301 tacgcatccc gaagcctgac aagactcacc cttaacttgt gttcgtcggc aatttgcccg 2907361 gttaacagtt tctccataaa ctgcccttcc agccggatga cattccgcac aagttctggc 2907421 agccgcttgg ttgaaaaccg ccgccacaaa agcattgttc ccaacagccc gatcacgctg 2907481 ccgacagcta catcagtcag cctcgctatc ataaaataac cggcgcccgc cccgccatgc 2907541 atactttctg tgataacaag cgcatttgcg gttaaaaagg gaacagccag cgcataattg 2907601 cggacgatca gcatctcaag aagacattgc agcgctgcaa tacaaaacgc aatataaaca 2907661 ccgcccggct taaaaaacag gattgcgcct gccagtataa caccgatcac cgttccggcc 2907721 gaacgctgaa tagccctgtg aagcgtaaaa acaacagtag tgccaagcat gaccgctgct 2907781 gccgaaagcg gaatccaata ggagcgtgca aagccgaatg cgagggcaaa catatcggcg 2907841 gcaaacagaa caattccgta ctttaacgct ctaatcaaaa ctggagactt ccagtcaaag 2907901 gcatttctca aaaagtaaaa agaggatggc aggcggcttg gttccccgtc aagctgctta 2907961 tcaaaacgtc ctgaagcgat atacaaaacc tcattgattt cttcaaacag cttccgccta 2908021 ggctcagatt cattttcatt aatctgaaac gtattgaaaa cccgtgcatt cgcaagcata 2908081 tctccggttt ggcgaagtgc cttttcaatc tgcgcggtct ctctgtccgg cgtttcagct 2908141 gaaaaatgaa taatggcaat aaatatgtcg tcagctttct caaggaggcg aaaaaatcgt 2908201 tcatcatgcc gcgatttttt ccgtctgttc cctttcccaa gaaccgtttg gcgggctgtt 2908261 ctaagcatga gcaccgtctg atgctgtgcg ttatgaaaac ctggcgttcc gacggctgaa 2908321 agacatgcag ccagctgatg atatgttttt tgcagcaccg ctccctccgg tccatgtttg 2908381 ttccataacc agccgattaa agcgataccc atggcgaaaa tgccgccgag aaacgtcagt 2908441 cccgctctga acagcgcttg tgaaggatcg gccggcagcc cggaactgac taaaaaggca 2908501 aggacaaaaa acatcggcgc agggccttga atgccgagcg cgctaaaaat aaacatcgcc 2908561 gctgcaccga tcagccccaa aacagccgcc atcatccaaa gcatcccgga caaaagcgtc 2908621 cctaaaccaa atgagagggc gatcccaata gaaaccaaga gcagcttcaa ggcgcgcttt 2908681 ttgtacgatt caccgcccgc atataaataa acaaagcctc cgatacttgc aattaatccg 2908741 taatccgtgt gacctgccaa tgcaccgacc agcacaggaa accctgaagc gaaacctgat 2908801 ccgatagcct ttttccaagg aaatggattt gcatgaatgc gaaaggcatc cttcacgata 2908861 ggcatgattc tttgattgtt cgcagcagtt ttgttcattt gacaaaatcc ttttcaatga 2908921 atgtgtagaa cttttccagt ttcttcgctt tagtatgccc aaaaacgcgg ttagcttctc 2908981 aattggtgcg cacgataaaa aaacagagac ttataccgtc tctgcttcat tacatcagtt 2909041 tattataaaa gcggcacctg tcaggactgt tttgtccttc tgccttcctt caagagcagg 2909101 tgaataaaaa ataaaggata aatcaataga tacccattaa acagccacca cacaagatca 2909161 aagtcactgc tgaatgtcca gaatgatagc gcctgcagac ctgaacaaca ggtcagcaca 2909221 agagaaatca gcgccatcag cttccagtca gcacgattca cccgctgtag gtacaagctg 2909281 tacaaccctg tgacagaaat caggatatcc agcggaaaaa aagaccagtt ccaagcgatc 2909341 ataaacggat ggtcatgatg tttaaaagcc cagctttccg gtatgagcga aaatccggct 2909401 gacagccagt acaagataaa accgatatca gtcacgagaa aaaacagctt catatatctc 2909461 atttgtactg cccgctttta tgtaccggct cagacaccgc aacatgctcg atcaggttta 2909521 aagacacaac accggcaata atcaatccaa ttgaaatgac tttcatgaca ctcacatgtt 2909581 cttgaaaaaa caaaaaacca acgactgtaa tcaagacaat tcccatccct gaccatacag 2909641 cataagcaac tgatacatca atggatttaa gcgtaagcgt cagaaagaaa agactccctc 2909701 cataaaagaa aatcaacagc aaactgggaa taagctttgt aaaaccagac gatagcttca 2909761 tgctgacagt tcccgcaacc tcaaacaaaa tcgccaagca tagaaacacc caattcatgt 2909821 ggcatcagcc tcctcatcag ctgttatacc gttaaacaaa acatctacaa ttgattcaag 2909881 tacctctcct gtcgtgaact gatgtttcag cggatattca gggtcataca cttgattgat 2909941 gctccctata tacatgtgaa caaacaggtc cggattgatg tttctgattc tcttttgctg 2910001 tttgcactca tttaataatg ctaggacaat cgcccattct tccttaataa acgcgtctaa 2910061 tgtaagccac gcatcgtaat ggtatttctt tagttcattt aataatccca tgttcagcag 2910121 ttccatcccc tgcggaaggc tgatcagcat ttgtttcacc ttttcgagca catttaaact 2910181 ttcattttca tagatgtctc tttctatttg cttcatttca gctataaatt gttcgacaac 2910241 cgcctcaaca agctgatctt tagatgaata atatgcatag agcgtccgct tgctcgttcc 2910301 cagcgctgcc gccaaatcat tcatcgtaaa tgaaaatcct ttctgcttga tcagccggaa 2910361 ggtttccgcc agaattcttt tatccatatt aatcccccgc tttcggtacc aagaaaacta 2910421 tttcggtacc aatattatac ggcagaaatt tatggaaatc aacaatatat aaaaaaacct 2910481 ctcctattgg gagaggttta aaagacactg cggaccaaac cgccgtccgc ccgaagtgcc 2910541 gcgccattga tcgcagagga aagcggactg cttaaaaatg taacgaagtg ggcgatttct 2910601 tccggacgga tcagtctttg aataatagat gtcggccggt tttctttcat aaaacgtgcc 2910661 tcagcttctt gaacagtcag gttttcacca ggatacagcg agttcagcat ggtttccaca 2910721 ccctctgtta aggtagagcc cggcatgacg gtgttgactg tgacattcgt gccggttgcc 2910781 agctccgcca aactgcggga aatggacagc tgcatcgttt ttgtcgcact gtaatgggcc 2910841 atttcctgtg acggcataat cgccgcttca ctggcaatga aaatcacacg cccttctttt 2910901 ttctctatca tgttatgcaa atacctgcgt gtcagcctta caccgctcat aatattcact 2910961 tcaaaaaaac gaaaccattc atcgtcggga atatcaaagt actccgccgg ttcaaaaatc 2911021 cctaaattgt tgaccaaaat atcaacctct ggatatgcct gaaacagctc attgcagcct 2911081 tcttctgttc ccaaatcaaa tgcagccgga taaagaaccg cttcagcatg ttgtgttttc 2911141 agttcatcta tcgtttgatt cactttctct tcccggcgtc cgttaatgat cactgccgca 2911201 ccttcttcag ctaacgaaga ggcaatagct tttccgatcc ctgatgtcga accggtcacc 2911261 agtgcggttt ttccttgtaa attcagcttc attattcatc cctccgtttt tgattcctct 2911321 tatttattga cagaaatctg attggtgaaa catctgctct gcaatcagta tgaaacagct 2911381 gggattgaaa tggaagtacg cactttttgg tgcctgtggt ttggagaaaa aataaagcag 2911441 aacctcttaa gaggttctgc tttattgtca gtatgtatgg agacggtggg agtcgaaccc 2911501 acgtccagaa acatcgatta cttaagcgtc tacgagcgta gcctgcatat ttatggtttc 2911561 actcatcttc ttgcctgcgg gcgggccttc cgagagctag tctgttcatc tcttcttacg 2911621 ttctcagacg ggaacgcaag cgtagcctac ttggatgtgc tcttcacaga cacataggca 2911681 atgtcaggaa gagctcgctg cgcttattag gcagctaatg ctacgttttg gttaaaactg 2911741 ttagttttgc cagttatatt taagtgcgtg tttacgagat cgcctctcgg ctcgcagctc 2911801 aagctcgatc catccctgtc gaatccgtaa cgtccccttg gtataaggga aatacgggag 2911861 aaaatatcaa gctctcactc aaactggcta tagtcttatt ataacatgat cacggctctt 2911921 ttcaattgtc aaatccttca aatgaatggc gtcgtgatct gatcgtgaac acagtatagc 2911981 acaggcctga ttttcgaatc aagcactatg cctttagaag cctttttgac tgtctctgaa 2912041 cgctctttcg atttcccgct tcgcgtcctt gcgcttcaga tcttcccgtt tgtcatagtt 2912101 cttcttccct tttccaaggc cgagaagcac tttggcaaag ccgtttttta aatacagctt 2912161 cagcggaacg agagaatagc ctttttcctt tgttaacccg atcagcttat taatctcctt 2912221 gcggtgcatt aacagctttc ttgtccggag cggatcgtgg ttatagcggt ttccctgctc 2912281 atatgggctg acgtgcatat tgtggagaaa cacttctccc cgttcgattt tggcgaagga 2912341 atccttaagg tttacgcggc cggcgcgaat cgatttgatt tcggttcctt gcagaacgat 2912401 gcctgtttca taggtttctt ctataaaata atcgtggttg gctttcttat tttgagataa 2912461 tacttttcct gacccttttg gcatgccaga acctcctctc tctaaggaaa aactgtccac 2912521 cttttgcgat acgctctatt ttaccaaatg tcacgtaccg ctacaatgaa aagctgtttc 2912581 cgaaagaaag caaatagagc gctgcggccc tatttgctgg ttgagctgct atttcttctt 2912641 tttccgtttc tgtttcggag cattctggaa gccgcgtttt ttctttttct tcttcggctt 2912701 agtgaaccac tccccttttt cctcagacgg agctggagaa acaggtgtat tggtgctttg 2912761 aacacgtttt ctggcaggct ttccgcgttt tctgctccgg ctgctgtcca attctctcgg 2912821 acgccgcgga gtgcctttca tgccgacaat ttcaaagtcg atattgcgct catctttatt 2912881 gacatcgaca accttgactg tgatttcatc cccgatgcgg aagacgttgc ctgtccgctc 2912941 gccaatcatt gcgaaatgct gttcgtcaaa gcggtagtag tcatctgtca taaagctgac 2913001 atggacgagt ccttcaattg tattcggcag ctcgacgaac attccgaagt ttgtcacaga 2913061 gctgatcatg ccgtcaaact cttcaccgat tttatcaagc atgtattccg cttttttcag 2913121 atcatccgtc tcacgctcgg cgtcaactgc acggcgctcc atagatgatg tatgttcggc 2913181 gatatccggc aggcgttcag cccacttttc ctgtgtcgct tcatcgacct tgccgttgat 2913241 caaatacgtt cggatcagac ggtgaacgat taagtccggg taacggcgga tcggtgatgt 2913301 gaaatgcgta tagaattccg ttgacagacc gaagtgcccc aagctttgcg ggtcgtattt 2913361 cgcctgtttc atcgaacgga gcataacagt agatataacc gtttcctctg gtctgtcacg 2913421 cacagcgtcc agaatgcttt gcagcgcgcg cggatgaata ttccccgccg ttcctttcac 2913481 cacatagcca aatgtcgtca caaattctaa aaacttttgc agcttttcag cattcggctc 2913541 ttcgtgaatc cggtatataa acgggacatt catccaatgg aaatgctccg caactgtttc 2913601 gtttgctaca agcataaatt cttcaatcag cttctcggcg acagagcgtt ctctgatcac 2913661 aacgtcttta accgctcctt cgtcatcaac aagcaccttt gcttctttga aatcaaagtc 2913721 aacggcgccg cggtccatcc gcttatcgcg cagaatttga gccagacgct ccatgtcttt 2913781 gaacatcgga acaagaggct cgtatttttg tttcagctct tcatcatcat caacaagaat 2913841 tttattcaca tctgaatatg tcattctttc cgttgttttg atgacacttt ggaagatctc 2913901 gtgctctgtc acctgtccct gactgttaat tgtcatttca caagaaagcg tcaggcggtc 2913961 aacctttgga tttaaggagc agatgccgtt tgacaatctg tgcggaatca tcgggatgac 2914021 acggtcaacc agatacacac ttgtccctct ttcaagcgct tctttgtcaa tcggcgagtt 2914081 ttcggttacg taatggctga catcagctat gtgaacgcca agcttgtagc ttccatcatc 2914141 aagcttcgtc acggtaactg catcatccaa atccttcgca tccgcaccat caatggtgac 2914201 aatcacctgg tcacggagat cacggcggtc tttcagatct ttttcatcaa tcgtgtcagg 2914261 cgtacttgat gcctgttcca tcgcgtcagc tggaaattct cccggcaggc cgtgcttatg 2914321 aatgaccgat aaaatatcaa tgcccgggtc gtttttgtgg ccgagaatgg tttcaacctc 2914381 accctctgcg ttcatgcggc cttcaggata gctcgtcagc ttgacaacaa ccttatgccc 2914441 ttccgcagct ccatttttcc catttttcgg aatgaagatg tcactcgtga tttttttgtc 2914501 gtccggaatg acaaagccga agtttctcgt ttctgtatac gtgccgacaa cccgctgaat 2914561 cgctctttct aaaatccgta tgacggttcc ttcctgcctg gagccgcttg attgtgagtt 2914621 cagacgcacc atgacgatat cgccgttcat tgccgtattt agctcattag gcggaataaa 2914681 cacatcactt aacgacgtat cctcaggcag caaaaaggcg aatcctttcg catgggctga 2914741 aatctttcct tttattaaat tcatcttctc cggaatgccg tagcggtcgc ttctcgtccg 2914801 tacgataagc cctttttctt ccaaggcgac taacgctttg acgagctctt taaactcctc 2914861 ggcttccgta atatttaaca tctcctcaag ttcctgaacg gtcagaggtt tgtacgcctc 2914921 ttccttcata aacgagagaa gcttttccat aaatgcttct ttttccatta tccgacctcc 2914981 tgttgattac caatcgagct tctctaaaaa ttcatacaca tcctgatgga cgaggtcacg 2915041 ttctttgtcg agtgtaatga catgccctga ttcctcgtac catttcagct gtttatcatc 2915101 agtttccact tcgttgtaaa taatattggc gctttcggta ttaatcatgt ggtcatgacg 2915161 ggcctgcacc acaaatgtcg gtgaataaat catatcgaca ttattccgca catcagcaat 2915221 taagtcttgc agcgccttga gggtattcat cggcgttttt tcgaattctt tcatttcctc 2915281 ttcaatttgc tccgggcttt tcccctcaaa ctttttgtaa ttgcgagcgt atgaaagaac 2915341 gccttgatac atgacctctt cactcttaat atgcatcggt gcgcacattg ggacaattcc 2915401 ctttatgggt acagtgtaac ccaatttcag cgaaaaaacc ccgccaagcg acagtccgca 2915461 ggcagcaatg ctctcataac cttcagattt taaatattca tagccatcca ttacgttttt 2915521 ccaccagtct tcgggccccg tatgtacaag ttcttcaggc gggacgccat gtccttcata 2915581 ttgaggcgcg tggcacgtat agccgcgttc attcaaatat cgtcccagca tccttacatc 2915641 cgctgtattt cctgtaaagc catgcagcaa aagcaccgct ttgtctccgc ctttaaatgt 2915701 aaatggtttt ggtgtcacaa ctttcatgct catgtctccc tttctatctg cacgatcatt 2915761 ttagttttcc acagtttaat cagaaaaaaa cgttttgaat atcatccaga aacgtgaaaa 2915821 aggcctgact tcacatcaga ccttatacaa acattgccct ataggatata agcaagcgca 2915881 atcgttaaca cgaaaaacaa gactgccagc actaccgtaa tgcggtgcaa aattaaatca 2915941 agacctcttg ctttttgttt cccgaagagc tgctccgctc cgcctgaaat cgcaccagat 2916001 aatccggcac ttttactgga ttgaagcaaa acgacaataa taagtgcaat gctgacgata 2916061 accaataagg taatcaaaac tgcgtgcatc ccatacacct ccagactcac tggctacatt 2916121 acttctattt tacatgaaaa gggttggcat gtcacgctgt atcagacgcc aaaaggccgg 2916181 ataagacgtt ttatcttggt taccctattc atatgaaaag gtcaaaggag aaaagcgatg 2916241 ccgcttatca gcatagacag caggaaacat cttttttatg aagaatatgg acagggaatc 2916301 cctatcattt ttatccaccc gccgggcatg ggacgaaagg ttttttatta tcagcgcctt 2916361 ctatccaagc atttcagggt gatttttccg gatttaagtg gccacggtga tagtgatcac 2916421 atcgatcagc cagcgtctat ttcctattac gcaaacgaga tcgcgcaatt catggacgct 2916481 ttgcacattg ataaagctgt gttattcggg tattctgccg gaggcttaat cgcgcagcat 2916541 atcggcttca cccgcccgga caaagtgtca caccttattc tgtccggcgc ctaccccgct 2916601 gttcataacg taatcggcca gaagctgcac aaactgggaa tgtatctgct tgaaaaaaac 2916661 cccggtttgc tcatgaaaat cctcgctggc agccacacaa aagacagaca gcttcgcagc 2916721 atattaacag accatatgaa aaaagcagac caggcccatt ggcatcagta ttatctggat 2916781 tcgcttggct acaactgcat tgaacagctg ccccgcctag aaatgccaat gctgtttatg 2916841 tatggcggcc tgcgggactg gacctttaca aacgcaggct attaccgaag atcgtgcaga 2916901 catgccgaat ttttcagatt ggaatatcag ggacatcaat tgccgacaaa acaatggaaa 2916961 acgtgcaatg agctggtgac agggtttgtg ctgacacatc attcatagga atagaaaacg 2917021 cttggcttcc ttgcgttttt tgttacttta ttgacttttg tcaacgaaat catagtaaaa 2917081 aagatcctca aatttcaaat taaaatagtg aagcatttta ccaatcacaa gctgccccgg 2917141 ccttctttct ccattcagca cgcggctcag tgtggcgggt gagactccga tttccagcgc 2917201 aagctgatta agggaataat cgttattaac catatactgc aagacataat cacgtctaat 2917261 ctgtatcttt tctactggca ctttcctcac cttccattcc tgaaaaactt ttttctatac 2917321 ttttacatta cggcttatgt taacttttgt caatacattt ccagtctacc tattcccttt 2917381 agtcaataaa catactaaaa tatgagtaac agtgagggac ggggtgagat atatggaaag 2917441 ctttggcgaa caattacggg cattgcgtga agagagaaag ttaacagtca accagctggc 2917501 gacttattca ggcgtaagcg cggccggcat ctccagaatc gaaaacggaa aacggggcgt 2917561 tcccaaacct gccaccatca aaaaactggc agaggcctta aaaattcctt atgaggggct 2917621 tatgtacaag gctggttaca tcgaagaagt gcatgaagcc agggcccctt atgaaacgaa 2917681 gtgcaagctg cttgaaaaag cggaggccta tgacctgaaa aaccttgcgc ttcttgagaa 2917741 cgaaaagtgg caatatctca ataaagaaga tttgctcatg ctggatcatt atttttcgtt 2917801 tatttcagat gaagcgaaaa aacggtctgc tgatgactga ctcttgatag aaatgtgagg 2917861 cgatagacca tgtcaccgtt cggacagcaa ttacgggagc tgcgccgcgc ccgcaaactg 2917921 acagtgaatc agcttgcggt gtactcaggc atcagctcgg ccaccatttc aaaaattgaa 2917981 aacggcaaac gcgggacgcc aaaacccgcc acgattaaaa aactggcagc cgtcctgaaa 2918041 gtgccgtacg aaaacctaat ggccgccgca ggccatattc aggcctttcc tgaagaaatc 2918101 cgcgaagcat ctgaaggcta tcaatccgtt tatgaaattt accagacggc tgtcacacgc 2918161 ggagcggagc acctcccgat tttcaatagt caaaaatggg aacatctctc aaagcaggat 2918221 attgaaaatc tcagcaaata cttcgatttt ttgtcttcag aagcaaaaaa acgcgcctct 2918281 tcctcataat cccctgtttc tctttctata ttttatcaat cacgcttgca tgccctccct 2918341 cgttatttgc gttataatag tgacagacga ggtgaaaagt atgaaccaat cagaaatgtg 2918401 tcctagattt gaaaaagcag tcgacatctt aagtaaacgc tgggtcgctt taatcgtatt 2918461 tcagctcttg aacgggtcgc agcgatttag cgaaattgaa gcagcacttc caaatctaag 2918521 cggcagagtt ctgtcagaac ggctgaaaga acttgagctt gaaggagtag tgaagcggga 2918581 tgtcatccct gaaactccgg ttcgcatcga atattcattg actgataaag gaaaggcact 2918641 agcacccata ttaggtgaga tttctaaatg ggcgactgaa tggattgacc cttcctttct 2918701 tgactaattg ctaaaatggt tctgatctca aagacgagaa aagaaccgtt ttttattttc 2918761 caggtgaaaa aaagatatct cagccgatat atagtacatc cacacattac gtttttaaag 2918821 gagaccacta tatgcgactg acgatttccc gcaaattcag cctggtattt ttgacactga 2918881 tcctgatcaa tttacttgta ggcggaatag gcgttcttaa tatgcagcat atcattcaaa 2918941 aaacagatga aatcaacaca aaatggattg acggcatcaa aggaatcact tcaattaatt 2919001 atgtaaccga gcacctgtct tctaaagaaa aggactttct gatttataca gacaaaagta 2919061 aaatggatac acttgatcaa gaaatgaatc aaatcatgga agacattaac caaaagctcg 2919121 ataactacga aaaaacgatc tccactgata aagagcagaa actgttcgag cagcttcaaa 2919181 ctaaagtgaa tacctatatg gatattcatg cgcaaattat cgaaagcggc cgcacgaatg 2919241 acatggacaa agcaagaggt ttattggttc agactgaggc cagctttgag gatatgaaaa 2919301 aaacaatcac tcagcttgtt gacttaaatc aagaaggcag caacacagcg gtaaaagaaa 2919361 cgaaggccgt ctatcataaa gggctcattt acactgcttt gcttgtggca gcatcaatcc 2919421 tcatcagcat tttcatctgg ctttatatca cgcgaaacat tgtaaagcct atcattcgca 2919481 tgaaggaatc tgccaatcat attgccgaag gcgatttgtc gaacgatatg gaggccctca 2919541 actcaaaaga cgagctgggt gatctgaatg aagcgctgca aaaaatggta gggaatctga 2919601 gagatattgt cggatattct aaagacatat caagccgggt tctttcttct tcacaggtgc 2919661 ttgcaaccgc aacgaatgaa acaagatccg gcagcaaaca tattaccgag acgatgaacg 2919721 aaatggctga gggctctgaa cagcaggccc aagacgcggt gacgattgcc gaatcgatga 2919781 atgagtttac cgaaagcatt gataaagcct ataatcacgg catcacaatc agcgatacgt 2919841 ctcaaaacgt tctcgaactc gcggtaagcg ggaacgaaaa tatggctacg tcattacagc 2919901 aaatgaaaac catccatcat attgttgaag aagccgtgca taaagtgaga tcactggaac 2919961 agcattctca ggatattaac aagctcgttc aggtcatcaa cgggattgcc gagcagacga 2920021 atttgctgtc ccttaacgcc gcgattgaag ctgcccgcgc tggagaaagc ggcaaaggct 2920081 tcgccgttgt ggcagaggag gtcagaaagc tggctgacgg cgtttctgat tccgtgcagg 2920141 acattacccg gattgtaaac gggacacagc aggagatcca cactgtcatt acgtacttgg 2920201 aaagcagctt tacagaagtc gaaaaaggaa cggaaaacct gacagacacc ggacaggcta 2920261 tgcagcatat caaacaatcc gtcacccatg ttgcagacag cattaaggaa gtaacggatg 2920321 gcttgaagca gttaacaaac caatcgatta ccatcaatca atcgattgaa aatatcgctt 2920381 ctgtatccga agagtctgcc gccggcattg aagaaacatt ttcaattacc gagcaatccg 2920441 cccattcgat ggatcaagtg cttctaaatg ctgaagagct tgagcagctg gccaatgagc 2920501 ttaatgagaa gatgggtcag tttacgattt aaagagaaaa aagaggctgg actccagcct 2920561 ctttttctat tctatgcagc tgattgaaca tgtttcgccc cggttctttt tttcttcacc 2920621 ggacttaatg cccgctccag ccaagccatg agcaaatccg cccctaccgc catcaccgca 2920681 gttggtatcg ctccggctag aataatcgca gttccgtttg ttgcgtttga gccgcgtacg 2920741 atcatgtccc caaggcctcc ggcaccgaca aatgtgccga tcgctgtaat tccgatggca 2920801 atgacgagag ccgtgcgaag gcccgccata atgacagaaa gtgcgagcgg gagctcaacc 2920861 attctgagca cttggaattt cgtcatgccc attgcttttc cagattctaa gtaggcatgt 2920921 tcaatactga taatgcctgt gtacgtgttt cgaataatcg gcagcaggga atacagaaat 2920981 aatgatagaa tcacggtatt tgcgccgagc cccataacaa gcattaagac ggccagcata 2921041 gcgagcgccg ggattgtttg aataacgttt gttacggcaa acacccaggc tgacaaacgg 2921101 cgaaaatgcg cgatgaggat tccggccgga accccgacga cagcggcaaa taaaacgccg 2921161 taagccgaca tgagaaagtg gcggccgaat tcatccatga cgtaactgcc attctgcgcg 2921221 taatacgtca ttaactgttc aagcacgttc attgacctct tccccctttc acgattcgaa 2921281 atagcgatgt ttttctaaat attccttggc aacgacagac ggttctttga gattgccgtc 2921341 gacttcatag ttaagctcct gcatcgtggc tgtgtcgatt tttccgagca ttttcttgat 2921401 gatgccttca agttcaggat gttctttgag caccttttcc ggaacaaccg gagagcagtc 2921461 gtacggcggg aaaaattgtt tatcatcctt tagcattttg agaccatagg acttgattct 2921521 tccatcggtt gaatacgcaa gcacaatgtc catttttccg cttttcaccg cgtcgtacac 2921581 aaggccgatc tgcatcggat acgtgccgcc gaatgtcatg ccgtaggttt tcgtaaaatc 2921641 ctgatagccg tttcctttga gcttcatcca atagttatca acgcccagct ttaattgcgg 2921701 cgcccatttt ttaacgtctg atacggtctc taaatggtat tggtcggcca gctccttgct 2921761 gactgtaaag gcatatgtat tatcaaaccc gtaggagtca taccacttta aatcatatct 2921821 ttttttaaac tcccgctgag taagcgccag cgctttgtcc ggatcttttt caggttccat 2921881 tctcaacgtg cctgtcagcg cgtctcccgt atatcttgtg gccgcaatgt cgatttcccc 2921941 gttcattaaa gcctgctgct gcaccgcgtt ggagccaaga tttttaatcg ttgttgtttt 2922001 gagatcagta tggtgttcga tcaactggcc aagcatgctg gcgatgattt ctgattcgct 2922061 catgctttgc gcgccgattt taatggtctg gtctgcagca gcgctgagac caggaagcga 2922121 acagccgctc agcgtcagcg ttgccgcaag tgctaaacct atcattaatt tgagatattt 2922181 tcttttcatg agccgcctcc ttatgacaat tccttcaatc tctgcatgcc ggcaggtgtc 2922241 agttttcgtt cagcaactgc cagcacataa tcaatcacaa ttgccaatat cgtgacaggt 2922301 accgcgcccc cgatgatata ttccggctga tataaattca gtccgataaa aatgtaatca 2922361 cccaatccgc cgcctccgat aaaggaagca agcgtggccc agccgattaa gtaaatcgtc 2922421 gatgttctga ttcccgccat gatcactggt gcggcaagcg gcagctccac caagcggact 2922481 tgttcagccg gcgtcattcc tattccttta ccagactcga gcagattttt gttgacgccg 2922541 cgaatgccgg tatacgtgtt gcgaagaatc ggcaatacgg aatagaaaaa caaagccaca 2922601 atggccggaa ccttccctac accaaggagc gggataaaaa aagcgaggat ggccagactc 2922661 ggcagcgtct gaatgatatt gacaatgccg ataatggtgc cggctccttt tttcattctg 2922721 gtaagcacaa ccccgagggg gacggcaacc agcacaccta agatcacagc aatgagcgat 2922781 atcgtaatat gctcgtatgt tttataaaga agctctcccc cattggtttg caaaaattga 2922841 acaatatgat gcatgactta tcgcccctcc ctatgacaat gctgcgagct gcttttcttc 2922901 tccccagagg gagtcataca cgatgtcgac cagacttgcc ctcgtcacaa ttccgatcag 2922961 gcgtcggtct tcatccacaa cgggaacata tttgacaccc cgttttaaaa ttttgcggac 2923021 cgtgtcgcgc agcagtgtgc cgcccagtac tgtgtatata tcttcatgta aaacttcact 2923081 gacgagattg gcctttttcc ggcattgatc aatgatttca acatcgacat agccttgcag 2923141 aacgcgctcg tcattgacga ccagcaatga atcgacccgt tcctgcctca tcagctgaat 2923201 ggcctcagaa agcgttttat ccgcggtgat cgttacaggc tgtgtgttca taatctggtc 2923261 aacccgttca acatccgggc tggatgactg aatcagccgc tccttgccga taaattcctc 2923321 aacaaattcg tctgccggat ttcttaaaat gtcatcgggc gttccaactt gaacgatttc 2923381 tcccgctttt aaaatcacaa tccggtctgc cagcttaatc gcttcatcca tatcgtgggt 2923441 aacaaatacg atggttttat gtaaggtttt ttgcagtttt ttaaattctt cctggaggga 2923501 atccctcgta atcgggtcga gtgccccaaa cggttcatcc attaagataa gcggcggctc 2923561 cgcggcaagt gcccgtaata caccaattcg ctgctgctgc cccccgctta attcatgagg 2923621 gtaacggtct acatattctg gccccatatc gaccaatttt aaaagctcac gcgcccgctc 2923681 tttccgctgc tgctccggcc atttcagcag ttttgggacg agtgagatat tctgctgaat 2923741 ggtcatatgg ggaaacaggc cgatctgctg aatcacatag ccaattttgc gcctgagctc 2923801 tacaggatcc tggtccatga tgttttcgcc gtcaatgaaa atcttcccgg cggaaggctc 2923861 aattaatcgg ttaatcattt tcattgttgt cgtttttccg cagccgctcg gcccgataaa 2923921 gcagataaat tcgccttttg caatcttaag atttacgttg ttcacggctt ttttgccgcc 2923981 cttgtatgtt ttcgagacat tttctaatgt cagcaaacat cgcacctcca aaattaagtt 2924041 tattcaattt gttcagttta aatttaattt ttcagacaat tgaatgcttc ccattataga 2924101 ataaagttta taaaataaaa agtttacaat ttgttcatat tatttataaa gtatgtgtaa 2924161 acgctgattt acccgcattg acgtgtgttg atctccttat tgctccaatt tcctgccaaa 2924221 ttctcttttg acagcatttt cgccgtatca aaaatgtggt atattgacat cggaattgtt 2924281 agctgaaagg atgaaaccgt tggagaaaga tccgttaacg atcattgaac aagccgagga 2924341 ccattttata gaaagaatcg cggaaaacat gcatgcattt ggaatgccct ctaccgtcgg 2924401 acgagtgctg ggcattattt atatgaatcg aaaaccgatg acgcttacgg aattatctga 2924461 ggccaccggc atgagtaaaa cacgtatgag ccaggtagtg cgggaaatgc ttgatgccaa 2924521 cattgccgag aaggtattcg aaaaaggcgt gcgaaaagat ttatatgagg ttgagcagga 2924581 ctactatcaa acatttatca cgctgttttc agccacctgg agcaaagtcg tcagcaaaaa 2924641 caaaatgatg cataaaaaac tcaatcggga gctgcttagc gtgttggatg aagagcttac 2924701 tcctgaagcg gaagaaaaag tgaatgagct gctgaaggaa ttaaaggaat ggctcgatta 2924761 ttataattgg ctcagccgtt tgattgagtt ttttgagagc gaagacattt ttaaatatgt 2924821 gccgaagccg taaaaagttc ccaaattcaa ttctgggaac ttttttaagt ccaatccaaa 2924881 tggttgaata tcaaacttcg agctcccaac gctggaaaat atgtttaaca gatactaaca 2924941 catgttgttt atttaaaaaa accacctctg ttgtatttaa atagaggtgg tttttctatc 2925001 agctataata aaatttcctt ttttcttttt aatcgggctt aatgctcgtt caagccagcc 2925061 catgaccaaa tcggcaatca ccgccatcag agctgtgggg atcgctcccg ctaatataat 2925121 cgcggttccg tttgtggcgt ttgatcctct gacgatgatg tccccgagac cgccagcacc 2925181 gacaaatgtc ccgatggccg taatgccgat cgcaatgaca agcgcggtgc gcaggccggc 2925241 cattatgaca gaaagcgcaa gcggaagctc gaccatccgc agcacttgaa attttgtcat 2925301 ccccattgct tttcccgatt caagataggc gtgctcaata ctgataatcc ctgtatacgt 2925361 atttctgata atcggcagaa gagaatacag aaataatgac aatatcaccg tattagcgcc 2925421 cagccccatg acaagcatca gcacggcgag catggcgaga gccgggatgg tctgaatgac 2925481 attcgtgacc gcaaaaaccc atccgcttaa tcttctgtat ctggctatca ggatgccgag 2925541 cggaattcca acaatggcgg caaataaaac gccatacacc gacatcagaa aatggcggta 2925601 aaattcctgc agcacgtaac cgccgttttg cgaatagtat gtgccaagct gctgtagtac 2925661 ttccatatga tccacctctt ttcttagtca aaataatgat gtttctctaa aaattccttt 2925721 gctacgacag acggctcctt cagcttgcca tccacctcat aattaagttc ctgcatcgtt 2925781 tccgtgtcga tttgcccaat cagcttattg atcacacctt caagttccgg atgctcctta 2925841 agcacctttt ccggaatcac cggtgaacag tcatacggcg gaaagaaacg cttatcgtct 2925901 tttaagattt tcagatcata tgctttaatc cgtccatccg ttgaataagc caaaaccgca 2925961 tccattttcc cgtttttgac tgcgtcatag actagcccga tctgcattgg ataagttgtg 2926021 ccgaactcaa agccatatgt gctgacaaag cctttatacc cgtcgccttt tcgtttcagc 2926081 caagcattgt cgacgcctaa tttatattgg gaagcatttt tcttcaggtc agacacggtg 2926141 ttaatatgct ccttttccgc aaactttttt gttacggtga aggcatatgt gttatcaaag 2926201 ccgtaggaat caaaccattt ataagaaaag cgcttttgaa actcgttctg cacaatgttc 2926261 agcgcttttt tcggatcttt ctccgcttcc ttgccgaggg tgcttgttaa atctgttccg 2926321 gaatagcgcg tggctgaaat atcaatgtca ccgcccagca tcgcttggtg ctgaacatag 2926381 tttgagccga ggtttttcac taaagcagta ttcaaatctg tatcatgttc aataagctgc 2926441 gcgatcatat tcgctacaat ttctgattct gtcatgctct gcgccccgat tttgatcgta 2926501 tcgtcagaag cgccgcctag acccggcaga gagcagccgc ctagcagcat gacaaagacg 2926561 agagcaaacg cgccaagcca tttgattttt gtcattttca acagtgccaa ctccttacga 2926621 tacttccttc atcccttgca agcctttcgg cgtcaccttt cgttctgtca cagccagaac 2926681 ataatcaata ataattgcca gaattgtgac aggcacggca ccgccaatga tatattcagg 2926741 ctggtatagg ttcagtccga taaaaatata gtccccgagg ccgcctcccc cgataaacga 2926801 cgcaagtgtc gcccagccaa ttaggtagat cgttgatgtg cggatccccg ccatgatgat 2926861 gggaatcgcc agcgggattt caacgagccg aatctgctcc cagccggtca tgccaattcc 2926921 tttccccgat tccaggaggt ttttatttac acctttaatg ccggtatacg tattgcgcag 2926981 gatcggcagt accgaataga aaaataaagc gacaatcgca ggcacttttc ctacgccgag 2927041 aagcggaata aaaaaggcta aaatcgccag actcggcagg gtttgcacaa tgtttacgaa 2927101 accgataacc gcacctgcgc cttttttcat tctggtaaga gcaacgccga gcggcactgc 2927161 aacgataatg cccaatacaa cggctatgag tgaaatatat aaatgctctc ctgttttata 2927221 cagcagctct ccgccgttcg tttgcaaaaa agtcatcatt tgattcatct taaaagagct 2927281 cctcccctgg tcagatcgtc atgagctggt tttcctcgtc gccccaaatg gaatcgtata 2927341 cgatatcaac gaggctcgct cttgtcacaa tccctgctaa atggttctgt tcatcgacca 2927401 ccggaacata cttgatcccc tgcttcaaaa tttttcggac tgtatcgcga agaagcgccc 2927461 ctttttgaac ggtatatata tctgaacggt atacatcgcc aacgatgctc gcttttttgc 2927521 ggttttgatc aatcatttcc acatcaacat agcccttcag cacgttttgc cggtccacaa 2927581 cgagcagcga gtcaacacgt ttttctctca tcagctgaat cgcctgagaa agcgttttgt 2927641 ccgcagatac cgtcaccggc gttctgttca tcatttgctc tacccgctcg atatccggtc 2927701 ttgactgaat caggcgctct ttcccgataa attcttcaac aaactcattt gccgggtttc 2927761 gaagaatctc atcaggtgtg ccgacttgaa cgatttctcc cgcttttaat atcacaatcc 2927821 tgtcagcaag cttaatcgct tcatccatat cgtgggttac aaacacaatc gttttgttta 2927881 aggttctctg cagttttttg aattcttcct gaagggaatc acgcgtaatc ggatcaagcg 2927941 ctccgaacgg ttcatccatt aaaatgagag ggggttccgc tgccagggcg cgcagcacgc 2928001 cgattctctg ctgctgtccg ccgctgagct catgcggata acggtctaaa tactctgggc 2928061 ccatatccac aagctttaac agctcgcgcg cccgttcttt ccgtttttcc tcaggccatt 2928121 tcagcagctt tggtacgagt gagatgttct gctggatggt catatggggg aacaaaccaa 2928181 tctgctgtat cacatagccg atttttctcc tcagctcaac cgggtcctgt tccataatat 2928241 tttctccgtc gataaagatc cttccagacg atggttctat cagtctgttg atcatcttca 2928301 tcgtcgtcgt ttttccgcag ccgctcgggc cgataaaaca gataaattca ccttttgcaa 2928361 tatctaaatc aatgctgttc acagcttttt tgccgccttt atatactttt gacacttgtt 2928421 ccaatttcag caatccgtgc acctccgcag gtttccttta aattttctga aaagtataat 2928481 ccttattata gtttgaactt tgtaaaataa aaagtttaca atgtgttgaa attatatgtt 2928541 atttatagat tatttattgt tatgaccgag acggaaaggg tgttcttaca attactccgg 2928601 atacctccca cttcctctgc attcagctat tttcaacacc aggaagaaat atgatatatt 2928661 gacaccatca attgccattt gaagggatga tcagctgtga aaaaaaccgc tctcgacatc 2928721 attgaacatg ctgaagagca tctcattgag aagattgccg aaaatatgca tacgtttgga 2928781 atgccttcaa ctgtcggacg tgtgctcgga attatttata tgaatcgaaa accaatgacc 2928841 ttaagcgagc tctctgaggc aacgggcatg agcaaaacac ggatgagcca ggttgtccgg 2928901 gaaatgatcg atgccaatat cgccgaaaag gtgtttgaaa aaggcgtacg aaaagacctt 2928961 tatgacgtcg agcaggatta ttatcaaacc ttcatttctt tatttgcggc gaattggaca 2929021 aaggtcgtga gcaaaaacaa agtgctgtat aaaaaattaa accgggagct gagtgatctt 2929081 ttacaaaggg acgggcttac cccggaagcg gaagagaaag tcaatcagct gctgaatgaa 2929141 ttaaaagaat ggcttcatta ctatgattgg ctgagcaggt tgattgaatt ttttgagagt 2929201 gaggaagtct ttcggtatgt gccgaaaaca aaagaatgca gctctctaaa ataagagagc 2929261 tgctttttgc atcatgaagt taagaccgga aacatgcctt tcagcccggc accaatcatc 2929321 ccgaccgcaa ccacggctaa gattaatccc atcagtctgg taatcacatt catctcggtt 2929381 tttccgagtt tgctgctgat aaaagcagaa tagtggaaaa agagaaaggt cagggcaata 2929441 acggcggcta tgccgatcat gacagccgca taatgaccaa tgccgctatg tccggcggaa 2929501 aggctcatca ctgttgcaat cgttccgggc ccagcaatga tcggaatgga taaaggtgtg 2929561 actgatatat ccgctttttc cttgctttcc ttatgttcat catggtgaag agattgcacg 2929621 tgcgattctt tcgcattcaa tagattatag gcaatgccga aaatgaatat gccgcccgcc 2929681 actcggagcg cgtgaatgtt gatatcaaac agtttaaaga taagatgacc gaaaaccaaa 2929741 aaagctgcga gaataaaaaa ggataaaata gctgccttcc gggcaatcgc ttttctttcc 2929801 gctgcagtat agccttctgt cagcgtcaga aatatcggta cgtttccgat cggattcgat 2929861 actgcgaata aagaaatgaa gacgtgaacg ataaatgaga acatcatata cctccttgtt 2929921 gatagtctct gcacaggaaa tagaatgatt ctccaccctt ttacccggag gcgatttccc 2929981 ggtaaacctt tatagcctgt cagaaacgcg ccatgctaca atgaagtgac aaattgaata 2930041 ggaaggacgt atacagatgt tcaaaaaaat tgcggcagat gccttgggct tatctgatat 2930101 cggaaaaatt atcgaacctc aggactatga caaaacagac gcagatgact atgtcatgca 2930161 tgaagataat gagaaaattt atttcttgat taaaacaaaa gcagacgagt attgctttac 2930221 gaacctggcc ctgatccatg tggacggcga acgcgccact tcctcaaaac gaacgttgaa 2930281 acgctatcct tattcgcaat ataaaatctc tgacgttttt cttgaaactg ccggaaaagt 2930341 ggatttggat gttgaaatta agttcaagct gggcggtgaa caattcgaca ttgatgtcca 2930401 caaagaccag attgaaaagt taaaagacct ttataaagca ctgcttcgca tcgctgaaac 2930461 aacctatgaa aatgacattt taatcaatca agcggagcaa agcttagata aagcagtgac 2930521 gattcttcac catacccgcc ctgagcacgt caatattgaa acgcaataca aagagctgac 2930581 cgaattcgga ttcacttggc tgacatccgt tcgctcgcag tatcatatta aggattttgg 2930641 ggatgtattt gagaaatata ttaataacta gataaaaaaa gacacagctg ctatcgtgct 2930701 cgtgtctttt tttgtatgaa tattgattac tttacaactt ttttctttta taataaaact 2930761 attagtctat tttccctata ttacagataa aggagttatt ttatgtattg tcctcaatgc 2930821 ggccatcaaa cagatggcgg aaatttttgt gagaaatgcg gatcaccgct ccccggtcaa 2930881 tcaggccacc agcatgcagc tcaaactgga gccgctgcaa agcaagcagc aaaacagttc 2930941 ggttcatttg tcttatccgt cctgaaacgc ccttatcagg aatgtaaagc aacaggcgga 2931001 gaacagctga tcagcgcaat cattacgatg gttcttttca gtttgctgac ccctttgatg 2931061 ttttatattc ttttttcaga cggtcccgga agcgtaagct ttacagcaat cttcttagag 2931121 ccaaccattt attttatttt atttctattt ggcctgcatg catgcatctt tttcgccctg 2931181 aaaatcgcgg gaaaccaagt gtctttcaag gattcattct caagattcgg agcatttctt 2931241 attcctttta cggctatttt gattcttgcc cttttcttct ttttattaca tacagacatt 2931301 tgctttacca tattagccgt tggtttaatc ggtgcattct tcgccattcc tcctgcgatg 2931361 ctgagcagtt accagcattc atataaaggg aaggttgatt tcatttactc aacgattgtg 2931421 atttatctga tcatctgcgt tacatttcag cttattatcg aacactatgt caaagaaatt 2931481 ttccgttata tgctctttta aaaacaaccc catcacctgc tggtgatggg gttgttttat 2931541 tgaatagacg ttaagtaaat tcttccgttc ttcactacgc cggtgtaggt ccagttatat 2931601 gttctgagct ttggactgcc gcctgatttt gtgatataga attcttcata cgtcttaatc 2931661 gtgatagccg acccattttg gctccagctt ttcacttcat agttattaaa gtcttctgtt 2931721 gtcccctctt tatttaattt cgacacgaga tgctgctggt cggaataaag ggaactgcct 2931781 ttttcaaggc tgtcttccat cagtgagaaa ttattttgat tcacggcatc tgcctgactt 2931841 tgcagataac tgcccataaa taatgtcact tgttcatctg taacatcgcc gcttgcagag 2931901 ctttcactgc ctttgttttt cgagccagcc caggcggaag tgtatgtctc tggtttatca 2931961 tttttgattt tctttatatt tgtgcctgca gattcgaatg ttgattctgc atcttcgaaa 2932021 atccactttt tctgtttttt atcatatgaa agaagatatt cataactcgg actgtcgtca 2932081 gtcatttcag actttgtata gtcgttatac gaagaagact ggtgaagttc ttttcctgtt 2932141 accgatacct gccacgttcc gtcgtttttc tgagagaggg caaatgtgtc caggtcaaaa 2932201 tcagtttcca agtatctatc ttttaagtat gaatccgcgc ttttcataga atcgacggtg 2932261 tccttcgtct ccgccttcca attggcactt gcctctgtca tctgggctgt attcccatca 2932321 gatagagctt tggagtattg ttttgttgtt ttgacaattg tgttcataat ctgttcctgt 2932381 gtatcttgat caggaattaa cgttaactcc atttctttat catcgatcgg aacgccggca 2932441 gtttttgttt ttccccacgg aaattctgcc tcgactgaag ctgtcattga tccatctgtc 2932501 agcagcggac catatgttac ggatttgaac ggatctttat gaattgattt accgttaatc 2932561 agcaaatctc ccttcccgct cttgatgtca ttcgctaagc tgaatgtcac atcgtctgct 2932621 tccaatgaga gatcaacacg aaagctgcta tcgccaatcg cctgaatgtc ttcctttttc 2932681 acaaggtcaa cgacatcgtt tttcagtttg gctgagactg tatattcgcc gggaatgtac 2932741 ggaccaaggg tttgtgcttg atctgctttc tttacagatc cggcttcctc tttattgaca 2932801 tatagatcgg tatttttata attgctgctc acttcaaaat aaacaggtgc tacctttaag 2932861 tcataatggt caaataccag caggcttttc ccgtcttttt ccgcatatac gatatccttc 2932921 tgggctgttt catcacgcag cgatgcaaaa agttcatctt ttttgtctgg atgatccttc 2932981 aaatatgtaa gaaacggttt tacattattt ttagtgagtt taagattgtc atttaccggt 2933041 gtaagcagag tcgcgatttg gtcctgatcc ccatcattta cggcctgttc aaacttgtct 2933101 actaacctat cctttgaagt aaaatacgct ccggttttat atgcggcgaa taatataacg 2933161 cacgccgcgg caatgctgct ccataaaatg atggttttct tagggatcgg ttttcgcgga 2933221 gcctgcctcg tttctgcagt gctagctgtt tcttgatttg cctgtttgct gccccctccg 2933281 atcggggtgc cgcattgttt acaaaacttg gctccttcat tattctggga gccgcaattc 2933341 ttacaaaata acatgacttt cctcctattc tactaatttg ataacattta ctgcttttca 2933401 tattttataa taaaacagaa tgaaattggg aacgaatgaa aaaattaaat gtctatcaga 2933461 ctaaaaaggt ggaatgaata tgcaaaagct caggattgaa ttaggagaag aaacaaatga 2933521 cgaattatat gatctattgc tgctcgccga tccatcgaaa gacattgtag atgaatatct 2933581 tgagagggga gaatgttaca cagcttgggc cggtgatgag cttgcagggg tttatgtatt 2933641 gctaaaaaca aggccgcaaa cagttgaaat tgtaaatatt gcggtaaaag aatctcttca 2933701 gaagaaaggc tttggcaaac agcttgtact tgacgccatc gaaaaagcga agaagctggg 2933761 ggcggacacg attgaaatcg gaacggggaa ttcgagcatt catcagcttt ccctctatca 2933821 aaaatgcgga ttccgcattc aggcgatcga ccacgatttc tttctcagac attatgatga 2933881 ggacattttt gaaaacggga ttcaatgccg cgatatggta aggctttatt tggatctctg 2933941 aaagcataaa aaagccgccg agagaaaatc ccggcggtct ttttattact tgtttaagtt 2934001 gtagaaagag ttgataccgt ggtattgagc agtttcagcc aactgatctt cgatgcgaag 2934061 aagctggttg tatttcgcaa cacggtccgt acgagacgga gcacctgttt tgatttgtcc 2934121 tgcgtttgtt gccacagcga tgtcagcgat tgtgctgtct tcagtttcac cagaacggtg 2934181 agagataaca gctgtgtagc ctgcgcgttt cgccatttcg atcgcatcga atgtttcagt 2934241 caatgtaccg atttggttta ctttgatcag gatagagttg cctacgccgt ttttaatacc 2934301 ttcagaaagt tttttcgtgt ttgtaacgaa gaggtcgtca ccaacaagct gaactttttt 2934361 gccaagacgc tcagtaagaa gcttgtggcc ttcccagtcg ttttcgtcaa gtccgtcttc 2934421 gatcgagatg attgggtatt tagaaacaag ctcttcatac cagtcaacca tttcagcaga 2934481 tgttttcaca acgccttcgc cagacagatg gtatttgccg tcttctttgt tgtagaactc 2934541 agaagatgca gcatccatag caagtttaac ttcttcgcca ggtttgaagc cggctttttc 2934601 gattgcttca acgattgttt gaagcgcttc ttcgttagaa ccaaggtttg gagcgaatcc 2934661 gccttcgtca cctacagcag tgtttaagcc ttttgcgctt aatactgatt tcaggctgtg 2934721 gaagatttga gcgcccatgc gaagtgcttc acggaagtta ggagcaccta caggcatgat 2934781 catgaattct tgaatatcca cgttgttatc agcatgctct ccgccgttta cgatgttcat 2934841 catcggtaca ggaagcgttt ttgagttgaa tcctccaagg tattggtaaa gaggaatctg 2934901 taagaaatca gcagcagcac gcgcacaagc catagatacg ccaaggattg cgttcgcacc 2934961 aagtttgcct ttgttttcag taccgtcaag ctcgattaaa agctgatcga ttgcgttttg 2935021 ttcagttaca tcaaagccaa gaagctctgg agcaatgatt tcgtttacgt tgttaacagc 2935081 tgttaacacg ccttttccaa ggtaacggtc tttgtcgccg tcacgaagct caaccgcttc 2935141 gtattcacct gtagaagctc cgcttggcac taatgcgcgg ccgaaagctc ctgtttctgt 2935201 atatacttca acttcaactg ttgggttgcc gcgggagtct aatacttcgc gtgcataaac 2935261 atcaacaatg tatggcatga gttttgtctc tccttttgat tttcaaatta tttttgaatt 2935321 aaagatgttc ctgtcatttc tttcggtttt tcaacaccaa gaaggtctaa taacgttggt 2935381 gcaaggtcgc ctaggattcc gccttcacgc agcgtaatgc cttctttcgt tacaatcaca 2935441 gggactgggt ttgttgtatg cgcagtgtgc ggttcgcctg attctgtaat cagaatgtca 2935501 gcattaccgt gatcagcggt aatgatagcg tgtccgcctt tagcaaggat cgcgtcaacg 2935561 acttcgccca agcattcgtc cactgcttca attgctttaa ttgttggttc aaccattccg 2935621 gagtggccga ccatatcagg gtttgcgaag ttaagaatga tcgcgtcatg cttgtcagct 2935681 tcaatttctt tgacaagcgc gtctttcact tcatacgcac tcatctcagg cttcaagtca 2935741 tacgttgcaa ctttaggcga gttgatgaga atacgctctt cacccgggaa ttcagcttca 2935801 cggccgccgc tcataaagaa cgtgacgtgc ggatactttt cagtttctgc aattcgaagc 2935861 tgttttaacc cgtgctgaga taatacttct ccgactgtgt tatcaagatt tatcggttta 2935921 aacgctacat agccgtcaac tgtttcactg aagtgagtca ggcagacgaa atacaggttc 2935981 tttggataat tctcgccgcg gtcgaagtca cggaagtctt tgtttgtgaa cgtgttggaa 2936041 atctggatgg cgcggtccgg tctgaaatta tagaaaatca cagaatcgcc gtcttggatt 2936101 ttcgcaacag gctcaccgtt ttcttttgtg atgacagatg gaatcacgaa ttcatcgtag 2936161 ataccatttg catatgaatc atcaacaaca tccagggcgc tgcggtaaga tgggccttcg 2936221 ccgtacgcca ttgcgcggta cgctttttct acacggtccc agcgtttgtc gcggtccata 2936281 gagtagtaac gtccggaaat gctggcgatt tcacctacac cgatttcctt gatttgatcg 2936341 ttcaactggt tgatgtacgt tttcgctgtc tgcggaccta catcacggcc gtcaaggaag 2936401 ccatggatat aaacctttgt cagcccttct tttttcgcaa gctttaacag tgcgaataaa 2936461 tgattgatat ggctgtgcac gcctccgtca gataaaagac cgaacaggtg caaggctttg 2936521 ttgttttctt tcgcgttgct gatcgcgtca aggaatgttt gattgcgttc gaactctcct 2936581 tcacgaatgg caacatttac gcgtgttaag ctttggtaca caatacgtcc cgcaccgata 2936641 tttaagtgac ctacttcgga gttccccatt tgcccttcag gaagacctac agcctcgcct 2936701 gaagcagtca aagtttgatg aggatactgg ttccaatagc ggtcaaaatt cggttttttc 2936761 gctaaagcga ctgcgttccc tactgtttcg ttacgtaatc cgaacccatc aagaatgatg 2936821 agtgcagctg gttttttact catattgacc ttcctccaat aattgaacga atgactgtgg 2936881 ctcaaggctc gcgccgccga ccaaagcacc gtcaatatcg gactctgcca tatattcttt 2936941 aatgtttgca ggctttacgc ttccgccata ttggatgcga agcttgtctg cagcttcttg 2937001 gctgaagctt tcagcgacgg ttttacggat atgcgcacac acgtcattcg catctttcgc 2937061 tgtagaagat ttgcctgttc cgattgccca gattggctca tacgcaataa cagaagcagc 2937121 aacttgttct tcagaaagac cagcaaggcc ttttttcact tggtcagcaa caagatcatt 2937181 tgttttgccg gcttcacgct cttcaagcgt ttcacctaca cagatgatcg gcacaatgcc 2937241 gtgtttgaaa gctgcgtgtg cttttttgtt aactgtttca tcagtttcag cgaacatttc 2937301 acggcgctca gagtggccga tgacgcagta gtcaacgcca aggtctttca gagcaaccgg 2937361 gctgatttcg cctgtgaacg cgccgctttc ttcgaagtgc atgttttgag cgccgacttt 2937421 taggtcagtg cctttcacag cagaagcaag cttttctaag aaaagcgctg gcgcgcaaac 2937481 aacagcttca gctttgtctg ctgctggaat ggaagatttc acttcttcaa cgaagctgac 2937541 agcttcgccg agtgttttgt tcattttcca gttaccggcg ataattggtt ttctcatctg 2937601 ttccacttcc ttatagcagt tttgagatta tttatcgttc agtgcagcta cccctggaag 2937661 ctctttgcct tccataaact caagggatgc gccgccgcct gttgagatgt ggctcatttt 2937721 gtcagcaagg ccgaattttt caaccgctgc cgcagagtct cctccgccga tgacagagta 2937781 tgtatctttc gcctctgcca atgcttccgc aaccgctttt gttccttgag cgaacaagtc 2937841 gatttcgaat acgcccattg gtccgttcca cacgacaagt ttgctgtttt tgatgacgtc 2937901 agcatacgtt tcgcgtgttt tcgtaccaat gtcgattgct tctaaatcac tagggatttc 2937961 agagatcggc acaattttca cgtttgcatc gttagagaaa tcatctgcaa cgagtacatc 2938021 ttcaggcatg tagaagttaa cgcctttttc tttagcgcgg tccataaatg atttcgcaag 2938081 ctcgatttta tcctcttcaa gaagagattt cccgacttca tagccaagcg cttttacgaa 2938141 agtataagca agacctccgc cgatgatcag gttgtctact ttatcaagaa gactttcgat 2938201 tacaccgatt ttgtctttta ctttcgctcc gccgatgatc gctgtgaacg ggcggtcagg 2938261 attggaaacc gcttttccaa gtacatcaag ctctttttcc attaagaaac ctgcaactgc 2938321 tggcagatgc tcggcaattc cagctgtaga tgcgtgagca cggtgggcag caccgaatgc 2938381 gtcatttaca tatacatctg caagctcagc aaatgctttt gcaagctcag gatcattttt 2938441 ctcttcacca ggatagaaac gtacgttttc caatacaaga acgtctccgt ccttcatctc 2938501 agaaatttgt gcttttacag catcgccgta tgcttcatcc gcttttttca cttctttgcc 2938561 aagcagttcg ccgagacgtg cagcgacagg agttaaacga agctcctcaa ccacttcgcc 2938621 tttcgggcgg cctaagtggc tcgcaagaag gacttttgcg ccttggtctg caaggtgttt 2938681 gattgttgga agcgcagcac ggatacgtgt atcgtctgtt acttccccgt ctttcattgg 2938741 aacgttaaag tcaacgcggc agaatacaac tttgcctttt acgtcgatgt ctttgagagt 2938801 ttttttattc atgcctagga gatcctcctt caaaatggtt tgcatacagc acgaaaaacg 2938861 tgaaaccgtc tgttcaagcg ataactccgc tagggcagat cgcagtcttt ttcggcacag 2938921 ggcagttcgt ctaaaagcca gggcagcggc cttaggcgaa agcgccggca aagctgctta 2938981 aaacgcggtc gtttctctat cacagagcgt tttctgaaag ccggtcttca tggaaaaagg 2939041 gaaagggagt ccgtcccctt cccttgtccg ctttcattat agcgcttcta ttcgaaagaa 2939101 ccaagtcagg tcctttttca gctataaatt aaagaccttt ttttgcgatg taagctgcaa 2939161 ggtcaacaac gcggttagag tagccgcttt cgttatcgta ccaagagatt acttttacca 2939221 tgctgccttc cataaccatt gtagaaagag catcgattgt agaagagttt ttgtttccgt 2939281 tgtagtcgcc agaaactaat ggctcttcgc tgtagccaag gattccttta aggtcgcctt 2939341 cagccgcttc tttaagagct gcgtttactt cttcagctgt tacttcttgg ttcagttcag 2939401 caaccaagtc aactagagaa acgtttggag ttggaacacg cattgctcca ccgttcagtt 2939461 tgccttttag ttcaggaaga actagagaaa ctgctttagc agcaccagtt gatgttggga 2939521 tgatgttttc agctgctgca cgcgcacgac ggtagtcttt gtgcggaaga tcaaggattt 2939581 gctgatcgtt tgtgtaagag tgaacagttg tcatcatacc gcgtttgatg ccgaatttat 2939641 cgttaagtac ttttgcaaac ggcgcaaggc agtttgttgt gcaagatgcg ttagagataa 2939701 catcgtggtt agccgcatcg tatttatctt cgttaacacc cataacgatt gtgatatctt 2939761 cttcgttagc aggagcagag atgattactt ttttcgcgcc agcttctaag tgtttcgcag 2939821 cgtctgcgcg ttttgtgaag aaaccagtag attcaactac gatttcaacg ccttgtttgc 2939881 cccagctaag tttagcagga tcgcgttctg cagaaacttc aattgttttg ccgttaacaa 2939941 caaggttgtt accgtcaact gaaacttcag cgtctaattt tccgtgtaca gaatcatatt 2940001 gtaaaaggtg agccagcatg ttagcatctg ttaaatcgtt aaccgctact acctcaactt 2940061 caggattgtt taatgctgcg cggaatacgt tacgtccaat acgaccaaaa ccgttaatac 2940121 cgacttttac tgccatgatt gtttcctcct ttaaataagt gagagatatt tatattgagg 2940181 gattattcat cccttaataa cttctttgcg gctccttcgt ctgtgacgag aaccgtgttg 2940241 cgtggctttt taaagtaagc ctcgatcgct tcggcttttg atgatccgcc cgctaccgca 2940301 ataatatcgg ggatggcgtc tatgtcatcc agctgcattc cgacagaatg cactttgtga 2940361 accacttcgc cgtccgcgtt aaaatagtag ccgaacgctt ccgtcaccgc gtcgttatca 2940421 tctattttct ttaaatcttc taaaggcgtg tttctgcgct gagccatagt tttagcttcg 2940481 ccgattccgt gaaccagcat actcgctgat ttaatggtgt tcagcacctc tttgacagaa 2940541 ggctcttcaa taatagatga ataggcgcct tgtgacagct gtcccggaac aaacaaaagc 2940601 cggtaagtgc ctgaagcctt ctccgccata tgcgcgcata tggtgttcgc ctggtttttc 2940661 acgtcttcgc ctaaaccgcc tcttgcaggc acaaacaaaa gctcgcggtt tttagaatcc 2940721 ggcgtcatca tttcggcgac agcttcaatt gtcgtaccgc cagttacagc gacgatattt 2940781 ttgcctgaaa atcttttttt catacatgcg acagccgctc ttcccatttc ttttttgacc 2940841 catggggatt gatcgctgtc tccggatacg ataatggcat cctttagatt taaacgttct 2940901 tttaatgtct tttccaaaag agtcaaacct aaaacatctt tcatcgtatc ttccaaaaca 2940961 gaaagcagtt catagccctc ttctgtcaat gtcatgccgt ttgtcttaat atcgaccagg 2941021 ttctgttcct ttaaaaactg aacctcgccc ctcagcacac gctcgctgat tccgagactg 2941081 gcagacaggc ttcttcgccc gatgggttct gtcagcctga tatactgcaa gatttcaaac 2941141 ctcttttgca taacgagcag aagatcaggc aataattttt tttgagcttg tattaactgg 2941201 ttcatgactc aaacgttcct tccttttttg ctggacatta tatgtcccgc tatgacaaaa 2941261 aacgtcccgt catagccaaa aaaaatcatt tctgctttct ttaattattt taacagggtg 2941321 gaattgttta ttcaactgtt aagagccaat tcatcgacaa tattcgcaga gttttcatgc 2941381 cgcgtcgttt tatccagcaa tattttatcc tatatatctt tatcttatac agaaagcgcc 2941441 aaatggtgca tcccaatata aacagccctt cccgtagaaa gggctgtttc attaaagcgt 2941501 tttcatttta tccaaagctt ttcaatttcc tcgagcgatt tgttcttcgt ttctggacag 2941561 atcgtaacga caaacaggaa acaaaggatg ttaatcaccg caaagatcca aaatgtatag 2941621 gcgagcccga aagaatcgat catcattggc acaaactgtc cgatcgccca gtttgctccc 2941681 cataaaaaga tggtcgcaat gcccgcggcc cgcgcacgca gatggttcgg gaagatttca 2941741 gaaatcataa tccatgtgat cggtccgacc gagacacaga aagcagcgac aaaacctaat 2941801 ataaggacga tcatcatgat cccgcttgtt aactcaaaat aaaacgacgt cccgattaaa 2941861 atcataaaaa tagccataaa agcagaaccg atggacatca gtttttttcg tccgacttta 2941921 tcaatcagca acaccgcaat aacggtaaaa ataacttcta caaccccgac gatacaagtc 2941981 gtcacaaatc cggcgttttg cccgaatccc atcattttaa agatttccgg cccgtagtaa 2942041 gtaatcgcgt tcatgccgat gacttggtta aacagcgcca gcaggattcc aatgacaagc 2942101 gcctttctga gacccggctt aaacagctgg gagagcgacc ccatttgttc tatttttaaa 2942161 gagttctcaa tgttctttaa ttcttctttt gcaacagttt ctccattaat acgtgtcagg 2942221 atctttaaag cttcatttgt tttgcccgct ttcgccagcc atctcggact ttccgggacg 2942281 acgagcagga caaggaaaaa aatgacggat ggcaccattc cataagcaag catccatctc 2942341 cagccggtgt gcacgcccca ttcgtatgtt ccggaccgct gcacagctag attaataaag 2942401 tatgttgcgg aaatacccag tatcgtaaag agctgatata acgaagataa acttccgcgt 2942461 atagcgggcg gtgccgcttc tgtaatatac gtaacagaga gcgatgagcc catcccgatt 2942521 cccagccccc cgataatcct tgcaatgatt aaggtggaca cgtcttgaga aagcgctgaa 2942581 acgattgctg atatcgcaaa taacaaagcg gctgtcatta aaatttttct ccggccgaat 2942641 ctgtcactta aaaatccgga tatcccgacg cccacaactc ctccaatcat aatgcttgaa 2942701 atgacaagtc cctccataaa cggactcagg ctgtataaat ctttcagaaa accgatggcg 2942761 ccagaaatca ctgccgtgtc atagccatac aataagccgc caagccccgc cgcacatgag 2942821 atcaaaatga caaatcccat tgaatggctt cttgttacag gaacatttgg ttctaattga 2942881 gttggagtat tcttcatttc cctgccctcc cgaatgttga gtaaagcgtt ttcatttaaa 2942941 ccttcaattg tacgtactta tattaaaatt taacgaaaat tacatttaat tagtacgtac 2943001 aaatatagaa taatcttgtt tgcattttct gtcaatgttt tcttacaaag aacgctgtga 2943061 tatactgaaa tttgtccgta tacattttgg aggaatggat atgttaccaa aatacgcgca 2943121 agtaaaagaa gaaatcagtt cttggattaa tcaaggcaaa atactgcccg atcaaaaaat 2943181 ccctaccgaa aacgaattaa tgcagcaatt cggcgtcagc cggcatacca tccgcaaagc 2943241 gatcggagac ctcgtatcac aaggtctgct gtacagcgtg caaggcggag gcacctttgt 2943301 cgcttcacgc tctgctaagt cagcgctgca ttccaataaa acgatcggtg ttttgacaac 2943361 ttacatatca gactatattt tcccgagcat catcagagga atcgagtcct atttaagcga 2943421 gcaggggtat tctatgcttt tgacaagcac aaacaacaac ccggacaatg aaagaagagg 2943481 cttagaaaac ctgctgtccc agcatattga cggactcatc gtagaaccga caaaaagcgc 2943541 ccttcaaacc ccaaacatcg gctattatct gaacttggag aaaaacggca ttccttttgc 2943601 gatgattaac gcgtcatatg ccgagcttgc cgcgccaagt tttaccttgg atgatgtgaa 2943661 aggcgggatg atggcggcgg agcatttgct ttctctcggc cacacgcata tgatgggtat 2943721 ttttaaagct gatgacacac aaggcgtgaa acggatgaac ggatttatac aggcgcaccg 2943781 ggagcgtgag ttgtttcctt ctccggatat gatcgtgaca tttacaacgg aagaaaaaga 2943841 atcaaaactt ctggagaaag taaaagccac actggagaaa aacagcaagc acatgccgac 2943901 agccattctt tgttataacg atgaaattgc gctgaaggtg attgatatgc tgagggagat 2943961 ggatcttaaa gtgccggagg atatgtctat tgtcgggtac gatgattcac atttcgccca 2944021 aatctcagaa gtgaaactaa cctctgtcaa acatccgaaa tcagtgcttg gaaaagcagc 2944081 cgccaaatat gtcattgact gcttagagca taaaaagccg aagcaagagg atgtcatatt 2944141 tgagcctgag ttgatcattc gccagtccgc acgaaaactg aatgaataaa aaaagcaatg 2944201 tatgggtctc cccgctacat tgcttttttt atagctgtta tctgtttttc caaacgtcag 2944261 cgatgatttc aaacgaacgc attctgtctg cgtgttcaaa ggtttctgag ttaaccataa 2944321 tttcgtcagc ctgtgtcgtt ttgacgaaat cttcaagctt cgccttcact tcttccggac 2944381 ctccgacaat cgtggagctc agctgctcat tgaccatcgc tttttcatac gggctccaga 2944441 tttggtccat atcctcaaca ggcggtttaa gctggttagg cgtaccgcgg acaagatcaa 2944501 gaaacctttg ataatgggaa gtcgcaaggt gctgcgcttt ctcgtttgta tctgccgcga 2944561 taatggtgac accgaccatc gcatacggtt cgtcgagcac gtctgacggc gtgaaggaat 2944621 tgcggtacag ctccaaagcg ggaaccgtat tcgccggtga gaaatgggcc gcgaacgcaa 2944681 acggaagacc aagttcgcca gccagacggg cgctgaagcc gcttgagccc agcagccaaa 2944741 tcggcacatc tatgccctct ccgggaatgg cgcgaacttg attgcgcaca tttcctgacg 2944801 gtttaaaata attgcgcagt tcctctaatt gttctggaaa atcctccccg ctgttgatgt 2944861 ttctgcggag cgctctggct gtcaattggt ctgttcccgg cgcacgtcca agccccagat 2944921 caatccgccc gggatacagt gtttccagtg tgccgaattg ttcagcaatg actaatgaag 2944981 agtggttggg gagcataatg ccgccggaac cgacgcggat tttcttcgtg cctccggcaa 2945041 tatggccaat caaaactgcg gtggcagagc ttgcaacacc ttctatatta tgatgttcag 2945101 caagccagta acggtgatag ccccattcct ctgcccggcg cgccaagtcc atgctgtttc 2945161 ggaatgattc tgcaatcgtt cctccctgaa caaccggaga taaattcaag acagaaagca 2945221 aggtatcttt gcgttggttg ttagacatat tgttctcctt tgcaaatgtg ttatcagtaa 2945281 acagcccaaa gctgtcaggt catgattgaa agaacttcta tcacaccata acacaactgc 2945341 attcaggaat aaaagaattt gattcgatga aattcgaaca atataaaacg aacggtttgg 2945401 aacattattc tgctccaaac aactccttag ccatctcaat aaagagctta gccgccagag 2945461 aagcctcctt tagcgacgga acagcaagct gcacatcacg gtatacctgc gggtccaatt 2945521 ccctggtcac cacatgctct ggcagcggca tccccgacat ggacatttct gataaaatgg 2945581 ccaggcccag gccttctctg atcatactga tcgaggtgtt gatgttatag accgtgaaag 2945641 ctgggtgcag cgtagcaccc gcctgcctga acatatcgat aaatggtgat tcatagccgc 2945701 cgtcacagac gatcatcggt tcatggtcaa gatctttcag cgtaatggct gaatgactgg 2945761 caagcgggtg atcgtccctg agcacgacag ccattttgtc ttttttcaaa tgaatgtact 2945821 ccatctcctc tgttggatac agaagaatcc caacatctat catccgcgta tgaagccact 2945881 ccttgacttc atttacagtt ccctcgtgca gcacgagctc aagtttcgga tatttttgtt 2945941 taaattcact gatcagcttc ggcataaaat aagccgaggc agttgagaat gtgccgatat 2946001 ggatcgttcc cagttcaagc cctttttccg ctgctgctac ctgctcaact ttttcaatgc 2946061 cttttaagac ttctctgatg tgtactaaga tctgttttcc cgtatccgtc agcatcaggc 2946121 cattgcggcg gtcacgaatg atcagcttta catcaagctc agcttcgatc gcagaaatcg 2946181 catggctgac agccggctgt gtcatgttca gcgcctgacc cgcttttgta aagcttcccg 2946241 tttcagctat tttcacaaaa acctttaatt gagtaatggt cataacaatt tacttatgct 2946301 ccttataaaa aagattcatt ttatttatct tatgttctac cgtatcatat gatggaaaag 2946361 ttctacaagg agtgaatgaa caatgaagca gctcccaaaa acgcggacag ctctcctgct 2946421 cgcatttctc gtcatcatgt ggggcgtcaa ttggccgctg tccaaagccg cgctcgccta 2946481 ttctccgcca ttattgttcg cgggcatccg aacgctgatc ggcgggcttt tattagtcat 2946541 agtcgcactg ccgcgtattc ataaattacg cttaaaagaa acgtggccga tttatcttgt 2946601 ttctgctctt ttaaatatta cattattcta cggcctgcaa acgatcgggc tgaattatct 2946661 tccggccggc ctgttttctg caatcgtctt cttccagcct gttctgatgg gtgtattttc 2946721 ttggctgtgg ctcggcgaat ccatgtttgt aatgaaagtg attggcctca tcctcggttt 2946781 tgcgggagta gccgtcatta gtgctgcggg ctttggcggg catatttctg tcattggggt 2946841 tctgctggct ctcggctccg cagtcagctg ggcgctcggg acagtatata tgaaaaaaac 2946901 aggcagccgc gtcgattcca tctggatggt cgctctgcag ctgacgatcg gaagcgtgtt 2946961 tctgcttatc tccggctttt ggacagaaag cttttcggcg atccaatgga cagctccgtt 2947021 tattacgagc ctgctgttca tctccgtatt cgttatcgca ctcggctggc ttgtcttttt 2947081 tacgcttgtc ggttcaggag aagcaagcaa ggtcgcatct tatacttttt tgattccgct 2947141 catatcaatc gtggccagct ccattttcct gcatgaaccg ctcaccctta gcctcttggc 2947201 agggctgctg ctgattgtca cgagcatctg tctcgtgaat acaaaatcaa aagcgcagaa 2947261 agctgcggcg attggtataa acgagaaagc tgcacaataa taaaaaccct cttgccggat 2947321 gcggcaagag ggtttcttat ttactgatgc ttgcgtcctt tgaccaaata tgcaactgta 2947381 atcaaaaggt agatcgccgc agtaatgccg gtaatgacaa ttgatgttgt catgatgacc 2947441 ccgatcagaa tggcgagtaa tgccacaatc gcaaaccatg tcgtgtacgg gaaccatttt 2947501 acataatagg ccggtgtttc cgtttgctgt tttctcgatt ttaaatgagc gaatccgatg 2947561 atcagccaaa tgaataaaac ggtatatccc aatgatccca ttaaataatt aaatgtttgg 2947621 cttcctgcga acagagaaat caatacgcca atatagagag aagaagtgca catcagaatc 2947681 gcaaacatcg gtacgttttt cgatgaaagc ttcgagaaga cctttggaag ccttccgtca 2947741 cttgcctgtg tatacaaaat gcgtgatgat ccgtataaac ctgaattcat agaagaaatg 2947801 atcgccagca ggatgactgc attcatgata tgatccgcgc ccggaatgcc taccatttta 2947861 aagaccatca cgaaaggact ttccggaacg gaattgactt ggttccatgg aatcaggctg 2947921 acgatgatga aaaacggcag caggtaaaac gcgacaatcc gtgtcagtgt gctgcggaca 2947981 gctttcggga caaccttttc cggatttttt gtctctgcaa gcgttacacc gataatttct 2948041 gtaccgccgt aagagtagat gacgacaagc atcgccgtga tcagccctgt gccgccgtgc 2948101 gggaaaaatc cgccgtggtc tgtcaggttg gaaaatccgg atgctgtatg atcaccgaat 2948161 gatacaaata agagcagcaa tcccagaata ataaagataa taataacggt aatcttgatc 2948221 attgccagcc aatattcagt ttcggcgaag attttaacag aaagcaagtt tacaatcgtg 2948281 acgataagag aaattcctaa tgccaacacc cagatcgggc agcccggcag ccaatattga 2948341 atgaaaatcg cagctacaac agcttcagcc gcaatgttaa gcacccacat tttccagtag 2948401 atccagtcca aaaagtaagc agcgtaattt cccaatacct gctggacaag atcacggaag 2948461 gttctggcgt tacggtttcg aacagccatt tccgccagcc cctgcataat aaacagcaaa 2948521 ataatcccgc cgagcaggta tgcgataatg acagatggcc ctgccacatc gatcgctgag 2948581 ctgctcccct taaataaacc tgcgccgatt gctccgccca gcgccatcat cataatatgg 2948641 cgggacgtca tcgtgcgttt taacgtttga ttgtcgtttt tcatcctctt ctacctctcc 2948701 ttctcgtttt caaaaacaaa aaagcccgcc gtctcctacc taatctaata gataaagaga 2948761 cgacgagcct tcggctgacc gcggtaccac tcttgttgat tcttcatgaa gaatcctgct 2948821 tttgacctgt aacgaaggtt agccgttaaa acatagggaa tattcaatct attccgttcc 2948881 gtcttaccac tcccgggcga gttcaaagaa gaatcaggct gcgtcgcacc accccgcagc 2948941 tctctgttct gatcactttc ttttactgct cccaatctat gtgttttagt tttctgaaaa 2949001 actcaaattt tatgatctga atatattaac ataatatacg tgcttctctt ttaactgtca 2949061 ataacttcag agaaaaaaga aactgttatt ttgtcccttt tcgaatggct ttccaaaagg 2949121 attctgactc gtttcctaat gcgtaaactg aaacacctgc tattttatat tgctttgcca 2949181 gatggctttt cgtttgaacg gttttttcgt tttcatacca cacgacatgt ttatgcttct 2949241 ttttgtcaac ataagaaaac gtcatcgagc ctgatttttt gttgaatgcc ggctttgctt 2949301 tttgtttttt gatgagggat ttgagctcat tccattccct tattgtgctg gtacttccgt 2949361 cttttacatc ccagtcatag ccgtacgcag ggattcccat gatgacttta ttggctttga 2949421 tctttttgac tgaaaactgc agagagcttt tgatccagtt tgtgcttgcc actgaccccg 2949481 gctcacccca aatgccgtgt tcatcgtagg tcatgacttg tacgaagtcg gcatatttgc 2949541 cgattttcgc ataatcatac ggccagctcc agtcatcatt tttatcatcg gcgcttttgg 2949601 ccggaacgga taccattgtt ttaatatgtt tcttattcaa agcctgtgag acatattgaa 2949661 tgaagttcga gtatgcagcg cggtcttctg gatttactgc ttcaaaatcg atattgattc 2949721 cgtaatatga gtgctttttg gccagtgtaa ttaactgatc tgtgaatcgt tttttcgctg 2949781 ttttattgct catgacccga ctcgctaaat ctccgtcaaa atcataaatg gcatcattat 2949841 agtttgaaat gacagcccat gtcttgattt ttttcttttt cgcatatgtc agctgcttag 2949901 ttggggcatc gccaatgatt tgtccgtttt tttcaaacgc aaatgtatcg gttgcgatgg 2949961 cattcatgta tgtatgatat ttcgtaagag aattgtatga agccgtatcc ccagtcgtgt 2950021 agcctactgt cataccggct gccttcgctt ctccttttgt atacataaac agaacaatcg 2950081 caatcgccag tgaaaccgct atgatcagcc attttttcat cgcatttcct cctgtatcaa 2950141 gtcatactct tctcatcggc caaaaaattg gaagttgaag ttttttcaag caaaaagccc 2950201 ggcatatgcc tgccgggctt cctgagttca gcggtcagag acgagaatat atgctgcctt 2950261 tactggtcca tgcaccccca caactaaatc catttcaatg tcggctgagt tactcggtcc 2950321 ggtaatgtag ttgatacatg aaggaacagt gacaccgttc gcaatgtttt ggcggatgat 2950381 atcactggct tgtgtcattc tcggtacaat gcttgatttc ggcacgatcg caatataagt 2950441 cgttggcaaa aggctgacag agcggccgat gtcttttgag gagaagagga caaccgtccc 2950501 cgactcagcc aatgtaattt cgctgaatgt aatccctaca ttggcttgct ccgctttttt 2950561 aatattttcc tcgcctttgt cagcatccca ctcccagacc ggcgttcctt cactcggcca 2950621 gtccttggtg agcaggcttt tcagtccgta ttcttcaaag cgggggtcct tcggaatgat 2950681 gacagggcct ccagaaaagc ggctgacttg ctcgcgcagg gcatcgtaaa ggccggttga 2950741 atccgtttca atcagctctg tatggatttt gacacaatgg tttttgagca ctgtgactaa 2950801 gtcatccgct gaataacctt caagtgtttt atattgcggc tgatgcgccc attcagggac 2950861 tgccacgcct cctgttcttc gttcacggcc caggctggat gcgattcggt ttaaaaagct 2950921 ctcttgattc tgaatggttc ccttcgtcat cactgctcct ccttcgtgcg ttcacttgtt 2950981 tctctgtccg caaaccagtc tctgaatctc gatttatgcg gtgccgggaa gtcgcgaatc 2951041 tgggtccaat ttttaagcgg gccgggccct ttcgaaattt tttcgtcctc tgtaaaaggc 2951101 gtcatggcgg ccggcgccca ttttgagccc attttgtaaa gcgataagga ggatgcgcca 2951161 agtccgaatg ctttcattgc aagcttttca ctgatcggcg ccctgccttc tttttcgacg 2951221 atattctgac gatgcttgag tagcagctca tgaagcggga ttttgaccgg gcaggcttct 2951281 gaacaagcag cgcacagtga agatgcgtac ggcagctcct tataatcgtc ataaccgccg 2951341 agcaacggtg ataaaacagc tccgatcggc cccgagtaga ttgagccgta tgaatgtccg 2951401 ccgacatggc ggtacacagg acagacattg atacaggcgg cacagcggat acattgcagc 2951461 acagactgga attccgttcc aaggatattg gatcgtccat tatcaacgat gacaagatgg 2951521 aattcttccg gaccgtccac ttcaccttcc agcttcggac ccgtcaaagc tgtaatatag 2951581 cttgtcagcc gctgtccgac agcacttcta gtcagcatgc tgactagcac ttcaaattca 2951641 gaaaatgacg ggacaatccg ctccattccc atgacggtaa tttgtgtttt cggcaaggtg 2951701 ctcacaagcc gtccatttcc ttcattggtc acaaggctga cggaacccgt gtcagcgatg 2951761 gcgaagttac agccggtaat gccgatatcc gcttccagaa actttttccg gagaatggcg 2951821 cgcgcatgca tcaccagctc ttccggtttt tctgtatgtt gatagtccag tctttcttta 2951881 aacacatcgc gtatctgctc tttattttta tgaagagcgg gcgctacgat atgtgacggc 2951941 ggatcgtgat catcaatctg caaaatatac tcgccgagat cggtttctac gacttcacag 2952001 ccttccttct ccagcacctc attcagattg atttcctctg tgaccattga tttagatttc 2952061 acaattttct tcccgttctt cttttgaatg acatcccgaa tataggaaga cgcctcttcc 2952121 gctgttttcg cgaaatagac atgtccgcct cttttcgcca cattttcggc aagctgtccg 2952181 agatagaaat caaggttttc aaggacatgc tgcctgattt cctctgataa tgagcgccac 2952241 tcctcccagt ttcccagttc ttctgctgcc tctaggcgcc gcgtccgcag acgctcctgt 2952301 gcacctgaaa cagcgcctct cataaattca ttatcaatcc cctgtgatac ccgctcttta 2952361 aaagcgtcag taccgatttt catcgccatg atcctttccc cctctgaatc cagttttatc 2952421 tgctgttgag cacttcggcg atgtgcatca ctttgacatt cttatctttt cggccaagcc 2952481 gtcccccgat attcatcaaa cagccgcagt cagcaccgat cagcacctct gctcccgttt 2952541 cctccacaca ttcgactttt tcatcgacca tctgctcaga aatctgcgcc atcttgactg 2952601 agaacgttcc tccgaatccg cagcagttat gtttgcccgg aagctctgta aactgcaggc 2952661 ccttcacatg gctcaacagc ttcatcggct ccttccgaac acccagcagc ctagtcatat 2952721 ggcacgacgt atgtaaggtc gcttttgtat gaagggtcgc gccgacatcc tctaccccaa 2952781 ggacgttcac aataaaatct gtcagttcat acgttttatc cgccagcttt ttcgctttat 2952841 cggcccattt cggatcatcc tgaaacaggt gcggatactc ccggaacatc gttgtgcagg 2952901 aacccgaagg actgacaaca tattcggaat cctgaaacgt ttcgatcatc cgtttcattg 2952961 cttttttggc gtcatgtaca tagccgctgt tgtaagccgg ctgtccgcag caaatctgcc 2953021 cttctggaaa atcaacctcg cacccaagcc gctccagcag ctcaaccgtt gcttttccga 2953081 catttgtttg aaacatatca acaagacaag tgacaaaaag tgagactttc atgatgaacc 2953141 cctctctcat ccccaatata tgatcaggtc atctgatgac ctgagttaaa ataactatat 2953201 gaatatcgta cactattctg acaatggaag gaaagagttt tctagggata ttttcatttg 2953261 tggcatatca aaaacactcc cgatctccca ggagtgcagt atatggttag atccagccct 2953321 tttcctcagc gatgctggcg gcttctgtcc gatttttcgc attaagcttt tggatgattt 2953381 ctgagatata gtttcgaact gtgccttgag ataaatagag ctccagcgta atgtcttttg 2953441 ttgtcttgcc taaagccgca agcctcagaa tttcttgctc tctaacggtt agcggatttt 2953501 cgtctcgcat catattaaac gtcagctcag ggctgaagac acgttttccc tttacacatt 2953561 ttcgaatggc atcggccaga tcgtcaattt caccgtcttt cagcagatag ccatgtgcac 2953621 cggcctttac ggcgcgttca aaatatccgg ggcgggcaaa ggtggttaaa ataatgacct 2953681 tgctgacgca gccttttttc attaattcct ctgccacatt cagcccgctt cgaaccggca 2953741 tttcaatgtc cataatgcat acatccggct ccagcttcaa aatagcatgt agcgcctctt 2953801 ccccgtttaa tgcttgtccg atgactgtca tatcctcttc taaatcaagc aaagatccca 2953861 aagcgcctaa aagcattcgc tggtcctcag caataaacag acgaatcatt cttttcgtcc 2953921 tccaatcatt ctgctttttt aataagcgga atcgtcagtg ccacaaccgt tccgttatgg 2953981 tctgaaaccg ttaatccccc ttcaatgagc atgagccgtt cttccattcc ccacaggcca 2954041 ttcccaaaca ttttctcctt cggcgctccc tttccgtcat cccgtattac gatcctcatt 2954101 ttgtcagcaa attgagaaat ggtgatggca cagtgggttg ctttgctgtg cttgataatg 2954161 ttagtcacgg cttcccgcat acacatactg ataatatttt gagtgacggg agatatcact 2954221 gaaaagtcgt cggctccttc gtattgaaag gtaatgttcc ccgctcttaa tatgtgctga 2954281 atgtttacga gctcctctgt tatcgtgacc gttctcatat cagaaaccag ctctcgaact 2954341 tgcttgagtg cggagcgtga actggtttcc atttcttttg cctcaagctt ggtccgttct 2954401 ggatcagatg cagccagccg ctgaatgagc tggcttttta atgtaagcag cgacagggtg 2954461 tggccaagag tatcgtgaag atcacgggcg attcgaacac gttcctccct tttagagagt 2954521 tcttttatct gttcgttggc ttgtgcaagc ttagcttcaa gctcaatcct ccgaaacata 2954581 gaacgaattc cgaatggaga aatgagcata atgacgagaa acgggagaac agaaaaaagc 2954641 tcccgaagcg agaccgaatt cgcgataaat tggtataggc atggaaaaag cagtataaag 2954701 attaaagcgc agaacgcacg gttaaaattc gttttctctt tgtaataacc aacaaagttt 2954761 gccggaaaaa aacctaagta tatataggtg atattgtaaa acacactata catcaaaata 2954821 accgccattt gcacgataag ccaatatgta aacgaagctt tgcccacgct gcagaataac 2954881 tggcgatatg ccgctacaaa aaggagcagc ataccatatc cgatcccctg tttgacccct 2954941 gattctttta ataaagagag gaacggcata atcgtataca ccagaaagat ataagggaaa 2955001 aacccgaatt ccttcgggaa aatagatatt gcctttttca tgtattacac cgcttcttgt 2955061 tttcttctta tatatttaga tagtagcatg aagagcatca tataagcgat taatatcaga 2955121 atatttttcc aagtcggact cccaccccgg acaagttccc acgctccgct cccgaaatga 2955181 taagacggaa gccactggcc aatgctctgc atcatgtcag gcatgacctc aaacggcatc 2955241 cacatccctc cgcctaaagc cagcagcata taaagcacat tactgattcc ggccgctgtt 2955301 tctacttttc tcatgaggcc gattagtgtg cctaatgcta aaaaaggcaa tgcgccaaac 2955361 aaaatccaca gtccgctcat catccattca aacggtgaca aggcaatatc attgatgatt 2955421 gcgccgaaca gaaatatgac ggtaattgat aaaacgtgaa tgacactttg gccgatcatc 2955481 tgagctgata aatagatatg atccggaaga ggcgtaaggc ggataaaggc ggcccagcct 2955541 tgtgaccgtt cttgtaccat tcggatgcca agcgtcatga tagaggaacc catcacgctg 2955601 aagactgtca tcgacatcag gtaatgggct tcccatgcac gttgatcagg gacgttggta 2955661 ttcactacat ttgtaaagaa ataataaaag gcaatcggca tgatcagaga ccaaagcaca 2955721 aagtacttgt tcctaagcac ccttttcatt tcagcgatgc tttgcttttg cagcacgttc 2955781 actcacatcg cctccctgtt gccgtcagcc agctggcgaa atgcctcatc gagcgttgct 2955841 tgctcaattc gaatatcccg tgcatgtatg ttttcttgaa agatcagcgc caacactttg 2955901 tctgtatttg atgtctggat gatggttctc tcatgctcgt ggatcactct ctcgacttcc 2955961 gggtgacaag acagcctttc caatgattca cttgaatgaa gcgtaaagga aacagactgt 2956021 ttttgaattc ttgagcggat ttgcattggt gagccgtctg caacaagctg tccttcagta 2956081 aaaaatagga ttcgctgtgc ggcatcatct gcttcctgta aataatgagt tgaaaaaata 2956141 atcgtttttc cttggtccga cagtccgtga atggtctgcc agaatcggtg tcttgatgaa 2956201 gtgtccatgc cgactgtcgg ttcatcaagt ataagcagct ccgggttccc ggcaagagcc 2956261 aaagcaaagc tcaaacggcg tttttgtccg ccggataatt tttctgctct tgttttcaaa 2956321 tcttctttgg tgagtgctgt taacgaaacg agttctttca tggacaatgg attcggataa 2956381 tagctccgga agagttcaag gatttcatcc accttaaggc ccggcatgac acttacttcc 2956441 tgaagcatta cacctatttt ttcacgaacc tgttgatcat cgggaacccg gttaaatagt 2956501 ttgatttctc cctcactcgg tttcagcaat cctaatatca tcgagacgac ggtcgtcttc 2956561 cctgccccat ttggcccgag aatggctgca atttctcctt tttcaatact gaagctgatg 2956621 ttgtttacag cggtttttcg ctggaaatgt tttgtcacgt tgcttactgt tactgcttct 2956681 ttcatcacat gagcacctcc tgatcgttta cattgattgt aaaatgacgg agaagacgat 2956741 gttagtatgg ggtgtcatga tgatggagtg acaaatgtca tttttttctc accccggtgt 2956801 ctaggcaatc ctcctcctgc atcttccaat tcatccatct tttctatctc ccatgtcctc 2956861 tttcttttaa actgctgtga cattcataga aagatacact cttcaaacca tccgagtgtt 2956921 atgatagaaa tattgaactt tatattactt tccggctgaa aggagccaat catgaacgaa 2956981 gcgattttgt ctagaaatca tgtgaaggtg aaaggcagcg gcaaagcatc tatcatgttc 2957041 gcacctggtt ttggatgcga tcaaagcgtg tggaatgccg tggcacctgc ctttgaagaa 2957101 gatcatcggg tgattttatt tgattacgtc ggttcgggac attcagattt gcgcgcatat 2957161 gacctgaatc gttaccagac acttgacggc tatgcccagg atgttcttga tgtttgtgaa 2957221 gctttagatc tgaaggaaac cgtgtttgtg ggtcactccg tcggggcctt gattgggatg 2957281 cttgcatcca tccgccgccc ggagcttttt tcccatctgg tgatggtggg gccttctcct 2957341 tgctatttga atgatccgcc tgagtattac ggaggatttg aagaggagca gctccttggc 2957401 ttgctggaga tgatggagaa aaattatatc ggctgggcga ctgtatttgc ggcaaccgtt 2957461 ctgaatcagc cagatcggcc tgaaattaag gaagagcttg aaagccgttt ttgttctact 2957521 gatcctgtca ttgcccgcca attcgcgaaa gcggcgtttt tttctgatca ccgagaggat 2957581 ctttcgaagg taacggttcc ctctcttatt ctccaatgtg cagatgatat catcgcacct 2957641 gcaacagtag gtaagtatat gcatcagcat ctgccttata gcagtctgaa acaaatggag 2957701 gctcgcggac attgccctca tatgagccat ccagatgaga cgatacagct gatcggcgat 2957761 tatttaaaag cacacgtgtg atataggaac gaaagggata gaggtgaccc tcttagatgg 2957821 acaaacaatt gaatgatgca ccatgcggtt tcctcgcttt gtcagaagag gggtcgatca 2957881 tagctgccaa ccgcaccctt atcaagattc tggattatga accggagcag gttatcggcc 2957941 agcacatgaa tatgatgttg accattcccg cgcagctttt ctgccagctt tatttttttc 2958001 cgcttttgaa attggagcat cacatcgaag aaatatacat ttccctgaaa gcaagagatg 2958061 gagaagaaat tcccgtcctt atcaatgcta ttgcgagaca cgatagcggg gcttctgtct 2958121 ttgattgtgt tctgattcca atgcgaaagc gaaatgaata tgaaaatgag ctgctgatag 2958181 ccagaaatga ggctcaggaa gctttgcttg ccaaacagaa agccaatgcg gagttagaaa 2958241 ttgccttgga aacgctgaaa gcaaaacaag aagaacttct tgagatcaat aaacaaaatc 2958301 aacaatttaa attaaacacc aaaagagagc ttgaactcgc cagaaagatc cagaaaaact 2958361 cgttgactga accgattgta aacgatcagg ttcagattga ctcttattac aacgcatcga 2958421 gtgaattgtc aggtgatctt tacggatatt atcaaatcga tgaacaccgt tacggcatta 2958481 ttatccttga tgtgatgggg cacggaattt catctgcatt gattacgatg tctcttcatc 2958541 ctttgttcca gcgccagatc acgcaaggtc tcagccccgt taaagttatg aaggaattgg 2958601 accggcacct tcacagcttg tttcaaaatg atgaggaagc aagacattat tgcactgcta 2958661 tttatctcga gattgatata gcacggcaaa gaattgatta tgtcaacgca gggcatccgc 2958721 cggcactttg gcaggacgat agcggaactc aacatctgct tcacgcgacc tcgcctccga 2958781 tcgggatgtt tgaagactta gagtttcagt caagcagcct ttcatacacg gaggacggaa 2958841 gattgcttct gtatacggat ggcgtgatgg atcctacggc ttcatgttat ttatttgatt 2958901 tactaaagga tcatcctgat tcgccaatcg ctgacctgaa ggagaaaatc cttacatcac 2958961 tgcagcatca aaaggaagct catcataaga gtgatgacga atgttttata ttagttgatg 2959021 taaaataaaa tgatccatga gacataacaa tgatttgtta catctcatgg atttttttgt 2959081 ttcagcgttt ctttggaata tgtcctgact ccgcatattg aaacacctgc aaggaaggca 2959141 gcgggtgtcc attaaaatca aataaagctt gattatctac agcacttccc ccataccact 2959201 tcccggcgtc ttcagggtcg tattcagcag catagctgga cgcccaccct gacccgtatg 2959261 tttcccataa cactttgttt ttctctatct gtgtcttcgg cccgactgga atccacgccg 2959321 gctcccagta gaaaacacca agtcctgctt tgcccgtatt cgccactgcc tccattacat 2959381 ctcttactgc agttgcctgg ccttgaacag aaattggata tggcaacgtc tgcccgcttt 2959441 ttggtgctgt atttccatgc ccatcgccat cctcagcggt ataggtgtac gatgtctccg 2959501 ccaccatgac ttttttgccg tacgtattgg caacagcctt cagcacggag gtcaaatttt 2959561 gtaatgtgcc atgccagaaa ggataatagg agctagcaaa cacatcataa tccactttgt 2959621 ttttgctgag tgtttctgca ataaatgaat accttccagc cgtttcagga ttggtaaaat 2959681 gcagggcgac caaaatattt gaatttgtct ccctgaccgc tcggcttcct tcattaaata 2959741 attggcacat cttcgtccaa tcagtctcac cggcaaatcc tcctgttgtt tcatttccga 2959801 cctgaaccat gccgatgtca acgccttcct tgatcatctt ttgcaggctt tgtttcgtat 2959861 actcatagag ctttgctttt tttgcttcaa agctgagatt cgcccaggct ttgggcacct 2959921 tttgtttcgc tggatcggcc cagaaatcag agtagtgaaa gtcggccagc accttcattc 2959981 cgttcgctgt cgctcttttt ccgatttcga tggctttttg aacatcattg tttcccccgc 2960041 catacccgtt gccatttgaa tcatacgggt gattccagat gcggacgcga acatagttga 2960101 ccccagcctg ttttaaagtt gtaaagatat cctggcgttt tccgtttgta ttgtaaaagg 2960161 tgacaccgct gttttccaaa gcaataacgc tggatacatc tgcccctttg ataaaatcct 2960221 tgttcatccc ctctactttt ttaacaaaaa gatcctctgc ccgaagctct gacacgtgct 2960281 tctccttctc aatggcagcg gcatatcctg ttgaactaca tgcactccac acgatggcag 2960341 ccgcaaagaa cattttcact ttgcttttca tgatttcatc cccccaagac ttagcaagcg 2960401 ttttcattct atagaaaaaa gaatccgccc atatcgagcg gagcatcagc ctaatgtgtg 2960461 tttacgacaa ttctcacttc atacttttcc atcgtcaggt cgcctgacaa tatgtctcct 2960521 gtcattatgt ccttcacact ctgatcaaac gtgaccagct gtttttcttc cgtgaaattc 2960581 atgacaaaaa tataatcatt gtcctgatcc tgcctcgctt gtacggagac gccttttccg 2960641 tgccgaaccg gaaaaactgg agagagagac aggtctgtga tcagaccctc atagaaatca 2960701 cgctgaaatt gatcctccaa acgcgcgccg ataaaatacg ccttgccctg ctgatactca 2960761 tggcttgtga ccgctggcgt gcgcgcataa aaatcttctt gatacaccgc ttccactgaa 2960821 gctgtcttta catcaatcac ggttgcataa tccttcattt catatatttg gctgcggtag 2960881 ctgacagcgt ttcgatcctt cggatacagg gtgtccgttt caagaggctc aactccaaat 2960941 atagcttgaa gatccggatg ccatccgcct gtgtatgtta agtcatgctc attcacaacc 2961001 ccgctgatat acgtcatgac taaggtgccg ccgtcagccg taaacgcttt taaacgggaa 2961061 acggtgtcct cgctgattaa atacagcatc gggacgatca gcagtttata tggtgaaaag 2961121 tcttgttctt tcgtgatgac gtcgacaggg atatcgtgtt cccagaatgt gcggtaatgc 2961181 tgctgaagcg tttgcggata acgttttgtc gccttcgcaa acccctgagc atcctcgagc 2961241 gcccaatgat tttcccagtc atataaaatc gcggtttgag ccggcctctt cgttccgaca 2961301 acttcggaca gccgttccaa tgtctcgcct accttggcca cttcttgaaa gacgcggttc 2961361 ttcgggctat tgtcatgatc cacaaccgct ccgtgtaatt tttctgatga cccccgtgat 2961421 ttgcggtatt ggaaatagag aacgctgtcc gagccgtggg caatcatttg catggatgac 2961481 agcagattca tgcccgggcg ctttgccttg ttgacgttat gccaattgac cgcgcttggc 2961541 gtacactcca ttaataagaa gggctgctgc ttcaagcttc ggtacagatc attgataaag 2961601 ccgaccttca tcgccaaatc agctgtgctt tcccagtcat tgtgccagac aggataagcg 2961661 tcccagctga tggcatcgac atgctttgca aatttgctgt agtcgaggcc ctgatacggg 2961721 atcaaatccg gtgtgtcagc cataaaattc gttgtgatag ggatatcagg cgtcaattct 2961781 ttcagcggaa tgatttcatt ttcataaaac gaaatcgttt gatcggtgac gaaccggcgc 2961841 caatctaaat tcaggccatg caagccattt tcaccgatcg gcgaagggct ttcaatttgt 2961901 gaccagtcat tgaacgtatg gctccaaaaa ggggtccacc acgcatggtt caatgtcttg 2961961 aggctgttgt catatttcga tttcagccac tcccggaaag catgctggca taaatcacag 2962021 tggcaatctc ccccgtattc gtttgaaatg tgccacatta acagcgccgg gtgatgtccg 2962081 tatcgttctg ctaataagcg gttgatgtgc cgtgtttttt ctcggtagac tttagatgtg 2962141 aggcagtggt tgtgccttcc gccgtgcagc tgtttgacgc gggaggcatt gacgcgcaaa 2962201 acttccggat aggtttgcga cagccaggcc ggacgggctc cgctcggcgt tgctaatatg 2962261 acccggccgc ctatactgtg aatccgctca aaaatatcat ccagccattc aaattgatat 2962321 acgccctcct ccggctcaag tgcgctccat gcaaaaatgc cgacagaaaa cgtattcgta 2962381 tgagaaagct tcatcagttt gatatcgtca gctaaaatat cgggccgatc cagccactga 2962441 tcggggttgt agtctccccc atggagcata aattttgctt ttgttacgtg cgttttttca 2962501 agctttgaca tcacattctc ctccttgttc tcttagccct tcgttccgcc tgcggttaat 2962561 ccggacacaa aattcttttg cagcataata aagatgacgg caaccggtat gctgataagc 2962621 agggctccgg ccgcaaatgt cgtatagctg gcccccatga catcattcac taaattgaat 2962681 agaccgacgg gcaatgtata tgattcaggc gttctcaata tggttgagga cagcacaaaa 2962741 tctccgagcg gaccggtaaa gccgttcatg gccacgactg ccgccatcgg ttttgataat 2962801 ggcagaatga tctggaagaa gattctggtg ctgctggctc cgtcaatctt ggcgctttcg 2962861 tctaaatcca tcggaatgga atccatgtac cctttcatca aatacgtatt catcgggatc 2962921 aggccgccga tataaagcaa gattagcagc cagtggctat tgatcattcc caagatttgc 2962981 gccagcacaa acaaggcaat taaagctgaa aactgaggaa tcatctgcag caataaaaag 2963041 agcgttaaag cgtatttcct ccctttaaac cgaaagcgcg aaaacgcata ggccgtaaac 2963101 gtcacacaga gcaaagaccc tgccattgta aacaggctga tcttcataga gttgacatac 2963161 cactgcacat attgaaggct ttccttgccc gcaaataatt ccttgtaatg atcgaatgtc 2963221 ggatgcttcg gaatgatgga tgtactgatt aagctgttgc cgggattaaa gcttgcgcct 2963281 gccgtccaaa ggagaggata aacaatgatg accgccataa aggctagcaa caagtaagag 2963341 aaaaggagac ggatatatct tctgactttc atatctgcca gcatacctta tgcctcctct 2963401 ttaaaagact ttgtctgtct gaactgccac aatgcgatgg agataacaaa tacagataat 2963461 aaaatggtta aagccgcagc aagtgaatat tggctggact gcattgtcaa tttataaatc 2963521 catgaaacga ggatatctgt cccgccggct gttgatccgg ttacagccgg acctccgcca 2963581 ttgaatagat agataatatt aaagttatta aagttaaacg taaactgagt aatgataatc 2963641 ggagccattg caatgaacac catcggaagc gtgatgtatc tcagctttga aaagacagaa 2963701 gcgccatcaa tcgtagctgc ttcatacaga tcgtccggga tggattgcaa tacgcctgtt 2963761 gagacgagaa agatgtacgg aaatccgagc cagccctgca tgagaatcaa tgcaagcctc 2963821 gaccaattgg catctgtcat ccacggaagc ggatctatcc cgaagaaagc caagatgtcg 2963881 tgattcatcg caccgaagct atcattaaac agtcccgcaa aaattaaaat cgtcacaaaa 2963941 ccgggaacgg cccatggcaa aatcagaatc gtccgaaaaa aacgtttaaa ccgaaggtct 2964001 ttctggttaa caatgatcgc gagaaaaatc cccaaggtga cttgcagtgt ggatgcagca 2964061 agtgtccaaa ccaccgtcca agccagtaca tcaaaaaaag tcgacctcca aatatcaact 2964121 gtgaaaatat ttgcgaacgt ttgaaaaccg acccaatcaa ttaattttgc aggaggagaa 2964181 tgatacaaat catagtttgt aaacgctaat gcaaagctga ataagatagg aaagatcacg 2964241 gcgaaaatta aaataaacaa agatgggccg ctgacgacat aaggatagcc ctcagaaatg 2964301 atatgctggt attgttcctt taaggaactt aatggcttat tttcatcacg ctgttttccg 2964361 ctttggaacg catcgcgaag atttacataa tacaccgcaa ggccaaagca ggtcacgatg 2964421 acagcaataa tcccttccgc cagcagaaaa acggaattat cccgcggcac ttctgttccc 2964481 agtgtaaaga ttccccaaaa ccccatattg agcagatctc caaagaccgc aaaaaacgat 2964541 gcgcctaaga aaagaaagac aatacctttt atccattgct tgttataaaa ttgcccgagt 2964601 cccggaatga tagaaagcaa caaagcgact tgacgatgct gcaccgtttt cacctctctt 2964661 acaatacaaa tctagctttc tctttatttt ccgctgtgct ttgccttaat ttgtcctttg 2964721 gccgtttcag ctgcttgatc caatgcttgt ttcggatctg ccttccctgt tgcaaccgtc 2964781 tgtaatgctg aatcagccgg cgtccatatt tcattcattt ccggaatatt tggtgttggc 2964841 tctgagaaac gggattgttc agtaacagcc cgtgccgcct cgcttttcat aatagccggg 2964901 tcattggcta gggatttcac agcaggaact tctttcgttt cttcatatcg tgttttagaa 2964961 tttttttcat ttgccaggaa aacggctaat tcttgcgcca gctcttcatt ctttgaaaat 2965021 gcactgacgt tgtagctttt gacgccgata aaggagctca tgtttttccc attttccagc 2965081 ttcggcagtt tcgtaatgcc ataattgatt cctgcattcg aaaaggcttc tacattccat 2965141 ggaccagaaa taattgcggc ggcttttcct tctgtgaaca gcgattccaa cacgttaatc 2965201 ccttgttctc caataatgcc agccgggaac aggccatctt tgtaaaactt ctgaatcagc 2965261 gccgcacctt tgacagctcc ttcattattg attccaatgt ctgacgggtt atagctccca 2965321 tctttggcct ttccaaaaat gtatccgcca tatccgctca tcacactttc tgcataataa 2965381 atttgatcga atagggctaa aaagccaaat ttgctgccgt cagcagtctt tttggaatag 2965441 tcgtaccact cttccagcgt tttgggcaat tccttttctg tgatgagatc tttgttgtaa 2965501 aaaagcacag tcgtttcgac cgcttttggc agtccataaa gcttttgatc taccatttga 2965561 gactgaatgg aagcgtcagt ataaagtgat tgaacgtctt ttttgacatg taattccttg 2965621 agtaatcctt ccgtgacagc ggttccgatt tggtcccctg gcattgttaa cacgtcaggg 2965681 cctgtgccgg ccggtccatc cattcgcaaa tcttcaatct gcttggcata cggtttttca 2965741 acgactttga ccttcacatc atgctctttt tcaaatgcag ccacagcgtc tttaatgccg 2965801 ttgctctttt ctttatcctc ccatacaaca agctctgacc cttttgaact cgatttggcg 2965861 ctgctgcttt cctttgggcc gcaagccgcc aaggataaac tgacagctgc gcagagcatg 2965921 aatacggaac acttttttgc cattttcatt gattgtcacc ctttcggtag gaatgaaagc 2965981 gctttaaaga taatatagca tgcctgagaa aatgtgtaaa caaactattt acttcataga 2966041 gtaaattttt ttacctaaat aaaaaatgac ttagtgtcct aagtcatcct taattcatac 2966101 tcttcctgac gattaattct gcgcccacat ataatgtttt taccgttctt ctcttgtcct 2966161 gcacttgttc aagcagtaat tgaacagcgt ttttacataa ttcatgtata tcaatatgaa 2966221 acgtcgtcag aggaggcgag acatacttcg cgaagctgat gttgttgata ctcacaatgc 2966281 ttaccctgtt tggtatggca attccttttt cgttcagggc ttgcagacag cccactgcaa 2966341 tcgggtccgc tgcaatcata aaagcagtcg gaagctgatc gcctaatgtg tcgatcgctg 2966401 ctgacatcag gcggtagccg ttttctacag agaatccgcg atgacagaaa atatagcgct 2966461 cgtccagcat ggctttttcc ctcatatagg atctgaaggt ttgttcacgg atgtccattt 2966521 catcctgatt ggtattcgga tttttgtatg tgccgccgat aaaaccgatg ctcttatgcc 2966581 ccttctcagt caggatgttt accgtcttcc ttgtcatttg tgccaaatcg ggccttaccg 2966641 agtcaaaatg atcgggatca ggagttgaat cgatgaacac gccgttttca gtgagatttc 2966701 tgaggaaagc cagctcttca tctgaaaatg tgccgacggc aataaaccct tccgtatgtt 2966761 caggaatgct ctcgattcca tccgctattt tataagtggt catatcgaca ttgaatgctt 2966821 tcgccagttt ctctacttct aatctcatcg ttttaaaata gacatcttct aattcttctt 2966881 tatctgtcag ccaatataaa aacgcaatat gtttcaccag cggccttact gtttttttgc 2966941 ggtaattgag cttttccgcc gcttcataga ttttctcccg tgtctcatca ggaacagaaa 2967001 ggctttcatc gttatttaaa acgcgggaaa cggttgagat tgaaaatccc gcttcctgcg 2967061 cgatatcttt aattgtcgcc attgtatctg cctccattat tcagctcgca ttgttttagt 2967121 aaaatatttt actttctttt tcacaaatgt caagtgcaca aagccctctg gctgccatgt 2967181 aaaaagactg aaccatttgc ggctcagtct cagttgttcg tatcattcgg aaccggcgga 2967241 attgcccggg aaatgagttg gttattgcac attttcctcg aaatatcccg aaagcacatc 2967301 ttccacattc gtcaaatgcg ccagcatggc ggcttccgcc tgtgcaccgt tcccggcagc 2967361 cacagcattg taaatccgtt cgtgctcctc atacagccgc tgaacggagg tcttcttgga 2967421 aaacagccag attttcctcg tttccctcat tgtttccagc agcaatgatg acacgtgatt 2967481 catcaagtgt ttaagaagtt cattttgaga agcgtccgca agcgcaagat gaaatgcaaa 2967541 gtctgctttc tctcccagct ccccgtccgc ttcaatgctg cccatttcct ttagtgcatc 2967601 ctgaattctt tcgagatctg cttctgtcct tttttcagcc gctagtgaag ccacgccgat 2967661 ttcaagcagt tttctgacct cgagcagctg cttgacgtcc tcttttttca tcagaagggc 2967721 ggctgagagc ggctgagaaa tttgattgag ctcaaattcc ttcagatacg tgccttctcc 2967781 ctgtttcatt tcgacaagcc ccatcgcttt tagcgcagaa agtgcttcgc gaaccgctga 2967841 acggctgact tgaaagctct cagcaagcgc ctgaacagag tccagtttat cccccggctt 2967901 caattcgcca tttttgatca tatctaatag ggcatccgct acttcttcat atattttttt 2967961 gttttaatct gtttatattt caatgcaatt caccccgtaa cttgtaggtc tggctgttta 2968021 cgatctatta tactctgttt tgtgggccgc caaaagattt tgactatttt gtcaaaaagt 2968081 cttgtacttt gatttttttc aaaatataat gctaggtaac tggtcttatt acccagtcat 2968141 cagatgatca tatcatctat agaaaccgct tacatatggc gccagtttat gtttcaagga 2968201 ggggtttggg atgcaatgga cacaggcata tacgcctata gggggaaatt tgctattatc 2968261 agcgcttgcc gcacttgtac cgattatttt ctttttttgg gcactcgcga ttaaacggat 2968321 gaaggggtat acagcaggct tggccacatt ggggatcgcc cttatcattg ctgtattggt 2968381 ttatcgtatg ccggcggaaa aagcgctgat gtccgcgaca caaggagccg tatacggatt 2968441 gttgccgatc ggctggatca ttgtgacgtc tgtttttttg tataaaatca ctgtgaaaac 2968501 gggacagttt gatatcattc gcagctctgt tctctcgatt actgatgacc gacggcttca 2968561 agctctcttg atcgcttttt cattcggggc ttttttagaa ggggcagcag gcttcggagc 2968621 gccggtcgcc atttctgccg cgctgctggt cggtctcggc tttaatcctc tttatgctgc 2968681 ggggatctgt ttgatcgcca atacggcgcc ggttgccttt ggggcaattg ggattccaat 2968741 tacagccgta gaagggccga cagggattcc ggcgatggag atttcgcaaa tggttgggcg 2968801 gcagctgccg tttttatccg tatttattcc tctttattta atcatcatca tgagcgggtt 2968861 caggaaagcc ttggagatct ggccggcgat tctcgtatcc ggtgtttcct ttgctgttgt 2968921 tcaatatctc agttccaatt ttttagggcc tgagctgccc gatgttttgt cagctcttgt 2968981 ttcaatggct gcgcttgctg tgtttttgaa atggtggaag ccgaaaacaa cattccggtt 2969041 tgccggtgaa caagagtcgg ccgcctcaat tgaaacggcg cgcacaaatc cggcggcgcc 2969101 tgcatacaga ggcggacaga tttttaaggc ttggtcgcca tttctgctgc tgacggcgat 2969161 gatttccgta tggggcattc catctgtcaa atccgcgctg accgggcatt atgaaggctc 2969221 tgcggtgttc ttgaagtggc tgaatgctgt tggagaaaaa ctgacttttt cccccggtgt 2969281 gccttttttg aacaatcaga ttgtcaatgc tgacggtacg ccgattgaag cggtttacaa 2969341 gttggaggtg cttggttcgg ccggcaccgc gatattgatt gccgcagtgc tgtcaaaatt 2969401 catcacggcg atttcgtgga aagactgggg aaccgttttt aaagaaacag tccaggaatt 2969461 gaagcttccg attttgacca ttgcttctgt cgttggtttt gcctatgtca ccaactcctc 2969521 gggaatgagc acgacactcg ggatgacact cgcgctgaca ggttcgatgt ttaccttctt 2969581 ttcgcccgtt ctcggctggc tcggcgtctt cattaccggc tcggatactt ctgccaacct 2969641 gctgttcggc aacctgcaga aagtcaccgc attatcagtc ggcatggacc ccgttctgtc 2969701 tgtggccgcc aactcttcag gcggtgtcac aggaaaaatg atttcaccgc agtcgatagc 2969761 ggtggcgtgc gccgcggtag gactcgccgg aaaggagtca gatcttttcc gctttaccat 2969821 taaacacagt ctgtttttgc tgctgctcgt ctgtatcatc acctttttgc agcatcacgt 2969881 attcagctgg atgattcctt aaaaaaatcc tcccgtctag ggaggatttt atttatatcg 2969941 ctttctcgct gccgatgacg gaatattcat ttgatcgcga tattttgcca cggtgcgtct 2970001 cgagatttgg atgccgtgtt gttcatacag caaatcgaca agcttttggt ctgaaagcgg 2970061 ttttgttttg tcctcttgat tgatcaggtt ttccagatgc gttttgactg cataattcga 2970121 cgcatctcca tcacctgaag cctcggcttt tgctgagaaa aagagtttca tctcaaacag 2970181 cccgtaaggc gtttgtattg ttttcccttt aatggcccgg ctcacagttg attcatgaag 2970241 gcttagacag tctgccacct ctctgagagt cagcggcttc attgcgcttc gccctttcag 2970301 aaagaaatcc ttttggcgtg tgatcagttc attgataatt ctcgtgattg tctgttttcg 2970361 ctgccgcagc gcgcggctca gccagcgcca ctcctgatat ttcgcagata aataggagac 2970421 agtatcctga caggagccgg atgataaaag cgttctgtac tgcggatgca gatcgatctc 2970481 gggaaacgag cgggtattca gttccgctgc gatgtgccca ttttttacgg tgataaaaat 2970541 gtcaggctca atatacacat cttgctctgg ccgggcaaac agaaggccag gtctaggatg 2970601 aagagccgcg atatcatctg agatatcttg aatggtatga agcggaattc ccgtctctac 2970661 tgaaagcgtt ttccattttt tttgcgcaaa agcatcaaaa tgagctgaaa ccagcatttc 2970721 cgcttgttca tttctgttcg gcagccgctg taattgaaga aggatgcatt cctgcaaaga 2970781 tctcgcgccg attccagccg gttctaacga ctggagtttt gccaaaacag cctccgcttc 2970841 cttggccgat acagataatc gccgtgctgc ctcctctata tcttcttcca agtacccgtt 2970901 tgaatcaagc gaatgaatca gataattaaa aatctttttt tcagtgtttg tcagattcat 2970961 atcgagtgac tgctgtttta acgcatcctg caatgttttt tgcggattac ttaattgaag 2971021 gcccgcttcc tgtgcattca tcctgttttt gtttgtttta tggtaagata gtggcggtgt 2971081 gtctgtttcc tttcgttcaa taagagggtt ttccagtgag agctcatcaa tgtactcggc 2971141 gagttctgcc gaatgatagc caagcagcgt gatggcctgc ctgagctcct gtgtcagttg 2971201 aggctttaat acttgtactt gctgaagttt catatccatc ttgctcactc ccctttcttc 2971261 attgtacatg attgagatca caccgtatac atttatgaaa aaggagctgc caaagaaatg 2971321 tctgaacttt tttccgtccc ttattttatt gagaatttaa aacagcatat tgaaatgaat 2971381 cagtctgagg ataaaatcca cgcgatgaac agctactacc gttccgtcgt ctcaacacta 2971441 gtgcaggacc agctgacgaa aaacgcagtt gtcctgaaac ggattcagca tttagatgaa 2971501 gcatacaaca aagtcaaacg tggagaatca aaataaacct tccgaattcg ggaagatgat 2971561 gatcggttaa agggctaacg ttcgcatcta taggggaaat ctgtttataa tgggggaaaa 2971621 agggagagaa cacaatgact catcaaatag taacgactca atacggcaaa gtaaaaggca 2971681 caacggaaaa cggcgtacat aagtggaaag gcatccccta tgccaagccg cctgtcggac 2971741 aatggcgttt taaagcacct gagccgcctg aagtgtggga agatgtgctt gatgccacag 2971801 cgtacggctc tatttgcccg cagccgtctg atttgctgtc actttcgtat actgagctgc 2971861 cccgccagtc cgaggattgc ttgtatgtca atgtatttgc gcctgacacc ccaagtaaaa 2971921 atcttcctgt catggtgtgg attcacggag gcgcttttta tctaggagcg ggcagtgagc 2971981 cattgtatga cggatcaaaa cttgcggcac agggagaagt cattgtcgtt acattgaact 2972041 atcggctggg gccgtttggc tttttgcact tgtcttcatt taatgaggcg tattctgata 2972101 accttgggct tttagaccaa gccgccgcgc tgaaatgggt gcgagagaat atttcagcgt 2972161 ttggcggtga tcccgataac gtaacagtat ttggagaatc cgccggcggg atgagcattg 2972221 ccgcgctgct tgctatgcct gcggcaaaag gcctgttcca gaaagcaatc atggaaagcg 2972281 gcgcttctcg aacgatgacg aaagaacaag cggcgagcac ctcggcagcc tttttacagg 2972341 tccttgggat taacgagggc caactggata aattgcatac ggtttctgcg gaagatttgc 2972401 taaaagcggc tgatcagctt cggattgcag aaaaagaaaa tatctttcag ctgttcttcc 2972461 agcccgccct tgatccgaaa acgctgcctg aagaaccaga aaaagcgatc gcagaagggg 2972521 ctgcttccgg tattccgcta ttaattggaa caacccgtga tgaaggatat ttatttttca 2972581 ccccggattc agacgttcat tctcaggaaa cgcttgatgc agcgctcgag tatttactag 2972641 ggaagccgct ggcagagaaa gttgccgatt tgtatccgcg ttctctggaa agccaaattc 2972701 atatgatgac tgatttatta ttttggcgcc ctgccgtcgc ctatgcatcc gcacagtctc 2972761 attacgcccc tgtctggatg tacaggttcg attggcaccc gaagaagccg ccgtacaata 2972821 aagcgtttca cgcattagag cttccttttg tctttggaaa tctggacgga ttggaacgaa 2972881 tggcaaaagc ggagattacg gatgaggtga aacagctttc tcacacgata caatcagcgt 2972941 ggatcacgtt cgccaaaaca ggaaacccaa gcaccgaagc tgtgaattgg cctgcgtatc 2973001 atgaagaaac gagagagacg ctgattttag actcagagat tacgatcgaa aacgatcccg 2973061 aatctgaaaa aaggcagaag ctattccctt caaaaggaga ataaatatgg ggaaaacagg 2973121 atacattggt gctgccattg ttgtggcagc ttgtatcatt attttgtcgg ccgtggtatg 2973181 tttacgggac acagtctatt accagcctat gcgctggact ggcatcatac tgtttttcgc 2973241 gggaattgtg atggttcccg catactcagc aaaaagaaaa cccggaaaag agaagtaatt 2973301 ctcttttccg ggtttttatg tttattataa tcttcccgcg cgaatatcgt ctgtcattcc 2973361 ctcataagga gccttcgaaa tcacttcttc gttgtcgact ccttcatttt tcagaaatgt 2973421 aatttccgca aattcaggta caacgtattt tggatacgtt tcatattttt cgcgggattc 2973481 tttcatcaaa tcaatgtggt cattttggta gcaaaccgta atttcaggat gttcatgcac 2973541 ccatttcggg aagaaaataa tgccatgcat gcgtttttca tttggcataa agtttaatga 2973601 aacatccgtg ccagtcggct ctgtccaaga cactttatat acgccttctg tcagtttgac 2973661 aatattcact tcctgatctc gaacccagcg tccggcaacc attccgctat gaattctata 2973721 atcaattgta tggtcgtttt taatataaat ctcgtattcc catccgtttt catacgtata 2973781 aatcatgtgg cttccgataa agttttccat cttacacact ctccttagtc ttttactgta 2973841 cttcataaat gtctagtaga acgtaatcag gggttctttc tgcggaaccg ataaacaagc 2973901 ggtcatggag ccattgatag acttcactgc ctgtttcaaa cgtcggtacc gtacgaaaat 2973961 aaacatgctc cggttcaata atttccccgg ctgccgcttg ttttcgaaac ggcttgctga 2974021 cttgccgtat tccattgttt tcaatgtaaa tcagttcatg atctgctgtt tcaatcacat 2974081 acctggcaga taaatctgtt ctgccgttag cgcgaatcat ttgtgaatcg gcaccgcccg 2974141 gcaaaatacg tccctttact tccccggtta ttgttcccga acgaatcgga atgaatcatc 2974201 tcagtcccag gcttgtctca ccaatcgtga taggcggatc aaccttgatt tctaaagagg 2974261 cgaatggttt taaaaccggc ttcttcacga gaaccacctc accttcagaa aaaatcatgt 2974321 aactatttac atgttcactt taacaccatt gcagttaact gtcaaacaat aggaacataa 2974381 aaaaacaagg actgtttgaa gacagtcctt gtctgaagct agctttgata agcaagatat 2974441 gtgctgacag tgcttttggc aagacaggca gaggaatcta taatcggaat ctcactttga 2974501 atatgatcta acaccgcatt taaatccgtg caggctgaaa tgatgatgtc tgcatgctga 2974561 ctgatttctt catatagcgt ctgccacaat gcttgtgtat gctgcatatg atttggctgt 2974621 ttgattgcgg cgataagctg gttcacagcc tgctgccaat ggtccttgtg aataacttct 2974681 tgtccatttc ccttcagaac tttttggtag atggcggatt ggatggttgg ctctgttcct 2974741 aaaaccaccg ctttttttgc gggatgcgga atctctttta tcgtttcctc aacaatatgc 2974801 aacataggaa ctgacaatgc ctgctgaatc tcttcatagt agacatgcgc cgtattacaa 2974861 ggcagcgcaa tgaaatccac gcctgttttc tcgagcttta ccgctccgtc gataatcgct 2974921 tttttcatct cgtcatggtc aattggacga tctgcataga agggcgtcgg gcatgaatag 2974981 atcatcatgt gcggatagtc aatatcgttt gaagccccat acagcttctg acagtaatca 2975041 atcaccttat caataaacgg cgaggtcgat ttcggcccca ttccggctaa tattccgatc 2975101 atcaaattca ttcctttcta cttcgtacgg accgcttctt cctctgagcc atcctcatag 2975161 aggataaagc ttttcgcagc atcctcacct aatgtaaact cgacttcaac agacaatgct 2975221 cgcagaaaga aacgggtttc cgaggaagga aataactcca gtctcagctg tccggcgatc 2975281 tccaaataaa gccgttcatt ctcggttgtc acctgtgcag ccgtcccatc ctgcaacagg 2975341 tagctgccaa catagcggct gtatatcgcc gtatcaattg cttttttctt tttatcagca 2975401 ggacgttccg ggacatcata tggctggcca aatagaatat gttccgccgc cttcagaatc 2975461 gcttgttcat attcagtatc ctcttcctta ttactcaaat agatcagcgt tttacgatga 2975521 tcgatatatc ggatcatcat cgtcgaatag ccgggccatc ctccgctgtg gctgacaatc 2975581 cgcccttttt caggactgtt ttgcagcacc cagccaaagc cataatcaat tgtttctcca 2975641 ttgttgaggc gcactggaga aaacgcagat tccttagaag ccttgctgat gaaatcgtcc 2975701 tgatataaag cctgatcaaa tcgaaacaaa tcgcttgtga cagagttaac cgtcccatct 2975761 ccctgtatgc catcgagata cacaacatag ttcgtttcct ccagctcatc agggaggacg 2975821 tatgtttcgg aatgtacatc atacacatat ccatatgcat aatgatcaat tcgctcaggc 2975881 gaaagcctcc tgttatacac tcttgtttca ttcatgcctg ccggtaaaaa aatacttgtt 2975941 tttataaaat ccgcatagct catgccagat gctttttcaa tgataaccgc cagcagcaca 2976001 taccccgtat tgctgtacat ccagccttca ttcggttcaa aataaccaga tagcccctca 2976061 ttcatcagca tatcgacaat atcctgattc accgcaatct tgtgtgaatc ccaattggca 2976121 aaaaaccatc ccatataatc aggaagccct gacgtatggt tcaataaatg ccgaatcgtt 2976181 acgccctgat acggaaaacc gggcagccag cgatccactt tatcctcata gccaagaatc 2976241 cccttctcct ccagcaagat gattcccaat gctgtaaaag gctttgacaa agacgctaac 2976301 tcaaacaaag agttggtttt caacgggcgt ttttccgtca tttccgcata gccaaaagag 2976361 tggtgatata aaatatcgcc accctccgca gccagaaccg tcccgttaaa ctgatgtttt 2976421 tcgcctaatg tctcaaataa cgtctgaaga tgctttcttt tattctgctt cattcctcca 2976481 cctcccatat ctctgtacgt tactaaccta ctaacgtttc aaatattttg aaaaatcctt 2976541 cagttagaga tcctttttaa cccatcacat atacctgccg ttcactatta tttagtgaaa 2976601 tgagatatta tgatattttc tgaattgtga ttaaaaaggc aactttatgc ccatgcaaca 2976661 gaaactataa aaaatacaga gaatgaaaag aaacagatag attttttagt tctttaggcc 2976721 cgtagtctgc aaatcctttt atgattttct atcaaacaaa agaggaaaat agaccagttg 2976781 caatccaaac gagagtctaa tagaatgagg tcgaaaagta aatcgcgcgg gtttgttact 2976841 gataaagcag gcaagaccta aaatgtgtaa agggcaaagt gtatactttg gcgtcacccc 2976901 ttacatattt taggtctttt tttattgtgc gtaactaact tgccatcttc aaacaggagg 2976961 gctggaagaa gcagaccgct aacacagtac ataaaaaagg agacatgaac gatgaacatc 2977021 aaaaagtttg caaaacaagc aacagtatta acctttacta ccgcactgct ggcaggaggc 2977081 gcaactcaag cgtttgcgaa agaaacgaac caaaagccat ataaggaaac atacggcatt 2977141 tcccatatta cacgccatga tatgctgcaa atccctgaac agcaaaaaaa tgaaaaatat 2977201 caagttcctg aattcgattc gtccacaatt aaaaatatct cttctgcaaa aggcctggac 2977261 gtttgggaca gctggccatt acaaaacgct gacggcactg tcgcaaacta tcacggctac 2977321 cacatcgtct ttgcattagc cggagatcct aaaaatgcgg atgacacatc gatttacatg 2977381 ttctatcaaa aagtcggcga aacttctatt gacagctgga aaaacgctgg ccgcgtcttt 2977441 aaagacagcg acaaattcga tgcaaatgat tctatcctaa aagaccaaac acaagaatgg 2977501 tcaggttcag ccacatttac atctgacgga aaaatccgtt tattctacac tgatttctcc 2977561 ggtaaacatt acggcaaaca aacactgaca actgcacaag ttaacgtatc agcatcagac 2977621 agctctttga acatcaacgg tgtagaggat tataaatcaa tctttgacgg tgacggaaaa 2977681 acgtatcaaa atgtacagca gttcatcgat gaaggcaact acagctcagg cgacaaccat 2977741 acgctgagag atcctcacta cgtagaagat aaaggccaca aatacttagt atttgaagca 2977801 aacactggaa ctgaagatgg ctaccaaggc gaagaatctt tatttaacaa agcatactat 2977861 ggcaaaagca catcattctt ccgtcaagaa agtcaaaaac ttctgcaaag cgataaaaaa 2977921 cgcacggctg agttagcaaa cggcgctctc ggtatgattg agctaaacga tgattacaca 2977981 ctgaaaaaag tgatgaaacc gctgattgca tctaacacag taacagatga aattgaacgc 2978041 gcgaacgtct ttaaaatgaa cggcaaatgg tacctgttca ctgactcccg cggatcaaaa 2978101 atgacgattg acggcattac gtctaacgat atttacatgc ttggttatgt ttctaattct 2978161 ttaactggcc catacaagcc gctgaacaaa actggccttg tgttaaaaat ggatcttgat 2978221 cctaacgatg taacctttac ttactcacac ttcgctgtac ctcaagcgaa aggaaacaat 2978281 gtcgtgatta caagctatat gacaaacaga ggattctacg cagacaaaca atcaacgttt 2978341 gcgccaagct tcctgctgaa catcaaaggc aagaaaacat ctgttgtcaa agacagcatc 2978401 cttgaacaag gacaattaac agttaacaaa taaaaacgca aaagaaaatg ccgatatcct 2978461 attggcattt tcttttattt cttatcaaca taaaggtgaa tcccatatga actatataaa 2978521 agcaggcaaa tggctaaccg tattcctaac ctttttagga atattgctgt ttatcgactt 2978581 atttccaaaa gaagaacatg accaaaaaac aaaatcaaaa cagaagccgg actaccgggc 2978641 ggcatatcat tttacgacgc cggataaatg gaaaaatgac cctcaaaaac cgatctattt 2978701 tgatggcaag tatcattatt tctatctata taaccgggat tacccaaaag gcaacggcac 2978761 agaatggcgc catgccgtct cagaggattt ggtgcactgg accgatgaag gcgtggcgat 2978821 tccgaaatat acaaacccgg acggtgatat ttggaccggt tccgtcgtgg tggataaaga 2978881 gaacacagcc ggcttcggga aaaatgcgct tgtcgcgatt gtgacacagc cctcagccaa 2978941 agacaaaaaa caggaacaat atttgtggta cagcacagat aagggaaaat cattcaaatt 2979001 ctacagtggc aaccccgtta tgcctaatcc gggcacagac gatttcagag atccgaaagt 2979061 catatgggat gaccaagata acaaatgggt catggtcatg gctgaaggat caaaaatcgg 2979121 cttttatgaa tccgataatc ttaaggactg gcattacaca agcggattct tcccagaaca 2979181 ggcgggaatg gtggaatgtc ccgacctcta catgatgcgg gcaagcgacg gaacgaataa 2979241 gtgggttctc ggtgccagcg cgaatggcaa accgtggggc aaaccaaata cgtacgccta 2979301 ctggaccgga agcttcgacg gaaaagaatt caaagcggat cagactgaag cccaatggct 2979361 tgactatggc ttcgactggt atggcggtgt gacgttcgaa gacagcaaaa gcacagatcc 2979421 attagaaaag cggtatgcgc ttgcctggat gaacaattgg gattatgcca acaacacccc 2979481 gacaatgaag aacggcttta acggcacaga ttctgtcata cgcgaactcc ggctgaagga 2979541 gcaggatgga acatacagcc tcgtctcaca gccgattgaa gctttggagc agctgactgt 2979601 ttcaactgac gaaatagagg atcaggatgt gaacggatca aaaacattgt cgataacagg 2979661 tgatacgtac cagcttgata cggatctttc ttggtcagag ctaaagaatg caggcgtcag 2979721 gctcagagaa tcagaagacc aaaaacgcca tattgatgtc ggcattttcg ctgaaggcgg 2979781 ctatgcttat gtcaatagag cagccacaaa tcagcctgac aaaagcaata cctatgtcga 2979841 aagcaaagct ccttatgatg taaacaaacg taaggtgcat ttgaaaatac ttgtcgataa 2979901 aacaacgata gaagtatttg ttggcgacgg gaaaaccgtt ttttcaaatg aagtcttccc 2979961 aaagcctgaa gataaaggaa ttacccttta ttctgacggc ggcacagcct ccttcaaaaa 2980021 tataacagtg aaacactttg attcgattca tgaataaaaa caggggcggc gcaggctgcc 2980081 cctgtttttt tattaggagc ggtattctct gttacatatt gggcattgta aggaatataa 2980141 ggctggtttc aaaggaggaa gcgaatgtct aaacaaggaa attttcaaaa atcaatgtcg 2980201 ctgtttgatc tgattttgat tgggatggga gccatctttg gatcagcgtg gctgttcgct 2980261 gtcagtaatg tcgcttcaaa agcagggccc tccggcgctt tttcctggat cctcggagga 2980321 gccattattt tgttaatcgg gcttgtatat gcggagctcg gagccgctct gccccgtacc 2980381 ggaggcatca ttcgataccc cgtttattca catggccacc ttgtcggcta cttaatttcg 2980441 tttgtcacga ttgtcgctta tacaagcttg atttcaattg aagtgacagc tgtgcgccag 2980501 tatgtggcct attggtttcc cggcctgacc attaaagggt ctgattcgcc taccatttcc 2980561 ggctggatct tgcagtttgc cctattatgc ttgtttttcc tgctgaatta ttggagcgtc 2980621 aaaaccttcg ctaaggcgaa tttcatcata tcgattttta aatatattgt gccgattacc 2980681 atcattattg tgctgatctt tcattttcag ccggagaatt tatccgttca aggatttgca 2980741 ccgtttggat ttacaggtat tcaggctgcc atctcgacag gcggcgtcat gtttgcgtat 2980801 ctcggcctgc atccgattgt atctgtagca ggtgaagtcc aaaatccaaa acgcaatatc 2980861 ccgatcgctt taatcatttg catcatcgtt tcaaccatca tttatactgt tttgcaggtc 2980921 acctttattg gtgcaatccc gacagaaaca ctgaaacatg gctggccggc aattggccgg 2980981 gagttctcat tgccgtttaa ggatattgcg gtcatgctcg ggttaggctg gcttgcaacg 2981041 cttgtcattt tagacgccat tctgtctccc ggaggaaacg ggaatatctt tatgaatacg 2981101 acatcccgcc ttgtttacgc ctgggcgcgt aacggcacat tatttggcat attctcaaag 2981161 gtcaataaag atacggggac accccgcgct tcgctttggc tttcgtttgc cctgtccatt 2981221 ttctggacac ttccctttcc ttcgtggaac gcgctcgtca atgtctgttc agtcgcgctc 2981281 attctttcat atgcgattgc acccatttct tcagctgcgc tgagggtcaa cgcgaaggac 2981341 ttaaacaggc cgttttattt aaagggaatg agcattatcg ggccgctttc ctttatattt 2981401 acagcgttta tcgtgtactg gtcaggatgg aaaacagtct cctggctgct cggttcacaa 2981461 ctcgtgatgt ttttgatcta tctctgtttc agcaaatata cgcctaaaga agatgtcagc 2981521 cttgctcagc agctgaaatc agcctggtgg cttatcgggt tttatattat gatgctgatc 2981581 ttttcctaca tcggttcttt cggacatggt ttagggatta tcagcaatcc cgtcgacctc 2981641 attttagtcg cgatcggctc acttgcgatt tattactggg caaagtatac cgggctccca 2981701 aaagccgcca ttgattatga taaataaaga agcaagaggt tttcttgctt ctttattctt 2981761 tacaaacaaa catacacgcg ataaaatgaa tgagagtcag tcattactgg aggtgttcct 2981821 catgccaaaa caaacatcgg gtaaatacga aaaaatattg caggcggcca tagaagtcat 2981881 ttctgaaaaa ggcctcgaca aagcttctat ttctgatatt gtcaaaaagg ccggcactgc 2981941 ccaaggaaca ttctatttgt atttttcatc taaaaatgcc ctcataccgg ccattgcaga 2982001 aaatctcctc acccatacac ttgatcaaat caaaggtagg ctccatgggg acgaggattt 2982061 ttggaccgtt ttagatatat taattgatga gacatttctc attacagaac gccataagga 2982121 tattattgtc ctctgttatt ccgggcttgc gatcgaccac tccatggaaa aatgggagac 2982181 gatctatcag ccttattatt cctggcttga aaaaatcatc aacaaggcca ttgcaaacca 2982241 tgaggtaacg gaaggaatca attcaaaatg gacggccaga acgattatca acttggtcga 2982301 gaatactgcg gaacgattct atatcggatt tgaacaagat gaaaatgttg aagtgtataa 2982361 aaaggaaatt ttcactttct taaaacggag cttaggtact gcttaaaaaa tgactgggta 2982421 acaccgctca ttttttaatg ccctaaaaat gactgacgtt cattcataaa atagagaggt 2982481 gtttcatttg aattgggttc ttgtttttat tgcagggctt ttagaggttg tttgggcctc 2982541 ttccctcaaa catgccgatt cgcttttgga ttggatcatc atttttatct taatcgcggt 2982601 cagctttatc ctgttgatcc gctcttatca aaaaatcccg atggccgcgg cgtacactgt 2982661 gtttgtggga atcggaaccg tcggaacata tctgactgga attgttctgg gcgaatcctt 2982721 ctcagcagcc caaatgttct ttttagcttt attgctggct ggcattttag gaatgaaatt 2982781 atttacgaaa gaaagcaaat ctcagccggg aggtgaaaaa taatggcatg gtttttatta 2982841 gtgattgccg gcatagaaga aattatagct gccattgcca tgaaatatat agacggaaca 2982901 agaaaaaaat ggccgatcat tgtgatgact gttggattcg gcttatcctt ttactgcctg 2982961 tcccaagcga tgatcgtcct gcctgccgga gtcgcatatg ccgtctggac tggcattgga 2983021 agcattggtg tttcggcggt cgggctcatc tggtttaagg agcggtttca gctttcacag 2983081 gtgatttcac tttgccttat cctagccggc gtcatcggcc tgcgtcttac gtcatcttca 2983141 taaaatcaag gcatatacag ctgtatatgc ctttgccatt aagcttcgtg atgtttttga 2983201 agatgaagcg gcggcgggat gagccagcct ttgtttttta gcagccttaa gtattttgcg 2983261 ccggttgccg ctttcgacat atgaaattgc ccaaacatca tggcaatatc ctcacgaatc 2983321 gattgcccca tcattttgct gcatgtcaca agacctgcag cattttctgc tgccgcggaa 2983381 gccgccacat ccggatcgag aaaccgtgca ccaggcggaa tatcgttaag atctgctgtc 2983441 ggcggttcag gagaagccgg cggcagcgcc accccgtttt ctttcaggat cgtgctgacc 2983501 tgtttgattt catcttggca tttctcaata gactcacgaa gcagcttctt caggtcgtca 2983561 tcaccgacat gattcaatag catttggtaa ttgccgacca ttttattgcc cgccatcaca 2983621 taactccaca agccgaatac ctcaccgtaa tgcatcggtt catcctgcgg atttccgctt 2983681 aaaataccca tgctcattct cctcccatat tcaatattgc acatttcata acgtgcccaa 2983741 gcggaggaac atttatgttt cagcggaaaa gatttatgaa atgaaacaaa acaaaaaaga 2983801 caagagtggc aagttgccaa accattgtct ttcctgttgt ttgattggac gcactgaagg 2983861 gattcgcacc ccgacagaca agataccgga aaccattcaa gtgcttttta gtatgagtca 2983921 ttgattctgt ctttaataaa ctttaacgag atggcgggat gctttgcgga aaacgaaata 2983981 cattttcggg gtcatatttc gcctttattt ctcgaagccg cgcaaagttt gcgccataat 2984041 attcttttcc gaagttttca atgttttgat ctggaacatt aacatatgaa cctgctacat 2984101 atggttgcat cagctgacgc actctttcaa ctgatgcaag atttgaatct tcttgtgatt 2984161 tatttttcca actagccgtc cattccgtat aaaataatgg atggcgccaa aaaaaggcag 2984221 tttcgtcttt agggactctg cttatagcac caccccaatt gataaaaaag aaattggctt 2984281 ctgttccagt agcatcttcc aaaaattttc tcatgattga aatgggttcg tcagaccaaa 2984341 aatcatgacc ccatgccgag gagaatttaa cactctgatc atttctgcca gggatgggtt 2984401 cgtcagggtc taagaaatct atagcatctg gatagtataa tgttttgata tctgcttctg 2984461 ttggagttcc cgcatgtaat aaaggtttta ataatcgaat caattcagtt ttcgaaccga 2984521 ggaaaattcc ttctgcatga cacaaaccat ttattttgct gtaaatttca aggtagcatc 2984581 ctaatcgttc atctacaaac ggagcccatt tctgccaagc tttaaatacc gtttctaatt 2984641 gttcccacgg ccagataata ttgaagacgg ttgcagtttt aggggcacga tgaactttga 2984701 atgtatattg ggtattatat ccaaagttac ctcctcctcc gcctctagaa gcccatagca 2984761 aatcctcatt gtgagattga tctgcgtgaa taatccttcc ttttgcatct accgttttca 2984821 gcgcgagaag gttatcactt ataaggccaa tcgatcgtga gagtacacca aatccgccgc 2984881 ccatcgtaat tcccccgatt ccaactgttg ggctatctcc aaacggagcc ataaaaccgt 2984941 ctcgagctaa tccctttaca agcgggccaa cgggaatacc agtttgaacg gttgcaatag 2985001 cgttttcttc atctaagaaa actttattca tgtcactcac atcaataaca attcctccac 2985061 ttactactga aaggttctta tctaaagcat ggcgaccgct tctgacacgt aagggcactt 2985121 tattctcacg agcccattta atggcattac ttacatcgta tgaattttgc gcaaaaacaa 2985181 agacaagagg atagacatcc acataagggt tccaattctt aatagcctct gtatagccgg 2985241 ggtctccttt gaagattaca cgccctgtca actgtgttga tcccatatat tatttcactc 2985301 ccaaagaaat tcgattcaga tactaaaata tgcaggagct ggataatcgc atagacaaat 2985361 gatctacgaa ctataaatat aatacgctaa ggcctttttc gtcggtgagg tctgctgaga 2985421 aacatttttc aaacaatttt gagcaaactt cctgtccaat cctccaacaa gcgttttttc 2985481 ttatcgtttt taggagcagt gtccagtttt tttcggagtg aatattcgtt taggccaaaa 2985541 gaaaagagag atgaagaagt gtttagtacc agaggtatac atccatacaa cagactctag 2985601 atcatcatat actgaatgta tgtagaaagg agacatcagc tttggcaaaa tatcggatta 2985661 tgacctttga cggcggcggt accttaggtg ctttaagttt acaactatta aacagattgg 2985721 ctaggcaaaa cccgaagtta attagtcgaa cccatgtatt ttcgggaaat tcaatcggtt 2985781 catttactgc ccttgcatta gcaagcggaa gatctccgag ggaaacactt cagtattttg 2985841 aggatgaaat cctacccgca ttcagcattt cccggccagg cggacctgtt ttcaaccaac 2985901 aattacccta ttccggtttt attaaagcgg taagaaattt tttcccagca gatcttcaac 2985961 ttatagattt aagaaaacga attgttgtcc catcattcaa attatactct caaaaactgg 2986021 accgttggac tcctgtctta tttcacaatt ttcccggctc tccctattta aatgaaaaag 2986081 tgagtgatgt catactgcgg agcagcggtg ctcccgcgac gcaacgcgcc tatcaaaact 2986141 atgtggacgg atatgtagta gcaacgaatc ccagtacagc cagtatcgcg tttgcagttg 2986201 gtaaagccaa cgtgccattg gatcaaattg cggtattgtc catcggaaca ggtgaagccc 2986261 cgactcggtt aagaagagat acgaggggat ggggaatggt aagtgcagat aacatacgtc 2986321 ccgaaaatct gaagaacctt cctccaaatt ggggagtcct tttggacagg tcgcctaatg 2986381 aacctttact gccatttctt cagatgattg ctggcggtaa tgggtactat gaatccatgg 2986441 tcagtgcgaa tcttctggga gatcgttttt tccggttaga tccgcggatt ccgaacttct 2986501 ccaaaacgga ccctgccgtc gttcccgctg tcattgaaat tgcgaacaaa acaaacttac 2986561 agcctgcgaa tcaatttata gagaagaact gggggagcaa ataattattt attttaaatc 2986621 aattctcgct tatacaattt tgtccgagag aagattctca aaataaatac aggcaatggg 2986681 tagaaccgga tttttttaaa ggtttgttaa tcacaagcta ataagatgaa tgaaaaaatc 2986741 aattcatact tcttcttttg aaagtgaggg ttcaaactaa agaatgtaat tgaaatgtta 2986801 ctctaaggta tgcaattccc tttttcacac aaaaaaagac aagagcggca aatcgccaaa 2986861 cccttgtctt tcctgttgtt ctattggacg cgctcggagg gattcgaacc cccgacagac 2986921 gtggtaccgg aaaccaccgc tctatccaac tgagctacga gcgcatatag actgcgttat 2986981 gagaacgtca gcacaactaa ttatacgata attcctttca aataacaacc ctctatttcg 2987041 agaggccgtt ttttaaatag acaaagcatc ttaattggca atctgacata cgatggtttg 2987101 aacccctgta tttttgggga aaatgggaaa aagagacgac tttgcatatc aggccagctt 2987161 tttgtttgac ctttattgac caaaaatgta tcatgtaact acatacttac ctaaaaggtg 2987221 aaggaggagc attatgaatt taatacctac agtcattgaa caaacgaacc gcggggaaag 2987281 agcgtatgac atttattctc gtctattaaa ggatcgtatc atcatgcttg gatctgcgat 2987341 tgatgacaac gttgcgaact ccatcgtgtc acagctttta ttcttagcag cagaagaccc 2987401 tgaaaaagaa atttctcttt acatcaacag cccgggcggc tctattacag ccggtatggc 2987461 gatctatgat accatgcagt ttattaagcc gaaggtatct acaatttgta tcggtatggc 2987521 tgcgtcaatg ggcgcgttcc tgcttgcagc cggcgaaaaa ggcaaacgct atgcgcttcc 2987581 aaacagtgaa gtcatgattc accagcctct tggcggtgcg caaggtcaag cgacagaaat 2987641 tgaaattgct gcgaaacgca ttctcttgct tcgcgacaaa ttaaacaaag tcctagctga 2987701 acgtactggc cagccgcttg aagtgatcga acgcgacaca gaccgtgata acttcaagtc 2987761 tgctgaagaa gcgcttgaat acggcctgat tgacaaaatt ttgactcaca cagaagacaa 2987821 aaagtaataa cacaacctgc aagagctgcg tctcttgcag gtttttttca tttcaaggaa 2987881 ttgactccct tattctatac tgctcccatt cctcatgtaa cagctcaagc gtcaaatcac 2987941 tcgtctgcct cacaaccaga tcagcaccaa gcatcggctg tccttgaccg acaccaaccg 2988001 caaacatccc cgcagatttg attgcagaaa tgcctgcttc tgcgtcttct attgccgcgc 2988061 aatcagcagg ggaaacatcg agcatcgctg cagctgttaa aaagatgtca ggatcaggct 2988121 tccccttcgc aagagtcgtc ggatcaacaa tggcatgaaa atcatcgata attgccaagc 2988181 gtcttaaaat cttaggagca ttgcgacttg aagatgctaa cccgattttt atattttcgt 2988241 ttttcaattg acatagaagc ctgccaatcc ccggtaaaag atcttccggc gtcaatttgc 2988301 tgatcagcat ttgataatcg cgatttttcc gatgcataag ctcttgtttc tccgcatttg 2988361 tatactttgt ttccgccccg ccaaagatca atatgctttc aagtgactct tctctgctga 2988421 ttccttttag cctttcattc atgtctctgt caaaagggat atcgatttgt tctgcgatgt 2988481 gcttccaagc gagaaaatga tattcagcag tatctgttat cactccgtct aaatcaaaaa 2988541 tgaccgcttt catatactaa tgcccatcac agcttcataa ggtttgaggc taatactctt 2988601 taagtcagcc cgctcctgcg gatagtttga aattagcact ttccaacgct catgaatcag 2988661 ttctggaggc gcttcgaaca gagccttttc ttccgataaa ttcacaacga caagaagctt 2988721 ttcccctcga tattctcgaa ggtaagaaaa gacctgcgga tcattctcct gcaacagctg 2988781 ataatcgcca tatatcataa tcttatattg ctttcgtaat tgaatgagct tctgatagta 2988841 aaagaaaatc gaatcttgat cttccaaaga ctctttcaca ttgatatctt gatagcggga 2988901 atttaccggt atccacgggt ctccggctgt gaatcccgca tgttttccgg catcccactg 2988961 catcggtgtt ctcgcatgat cccttccttt tatcatcacg gctttgacaa actctttttc 2989021 tgacatcgtt ttgttttcga cgactagttc acgatatgca ttctttattt caagatcatc 2989081 atacatctcc agcggcatat cgctgttgac catgccgatt tcttctccct ggtaaataaa 2989141 cggcgttcct ttcatgccgt gcagaaccgt tgcaaatgcc ttcgcacatt ccttacgcag 2989201 tttcctgtca ttgccccagc gggaaataac cctcggctgg tcatggttct caaaataaag 2989261 ggtattccag ccgacattca ttaacccggt ctgccacctt gtcatcgtct tttttaaagc 2989321 aatcaaatca aacggcttga tctgccattt cccatttggc gagttttgtt ctttatcaat 2989381 atccatatgt tcaaatgtaa agatcatatt cagctcttgc ctgcttgcat ctgtgtactt 2989441 tttcgcctct tcaatatcag agccgtttgc ctctccgact gtcatgcagt cgtaatgaga 2989501 aagcacttcc ctgttcatct cttgaataaa ctcatgaaga cgtgggccgt tagagtgata 2989561 acggccgaca atatagctgc ggctgtgatc cgtttcgtag tccggaaaat cggtgtattt 2989621 agaaatagag ccaatcacat ccatccgcca gccgtcaacg cctctatcca tccagaatct 2989681 cattacatca taaacttccc ggcgaacggc ttcgttttcc caatttaaat caggctgttt 2989741 tttcgaaaag tagtgcaaat aatactgccc tgttccttca tcgtatgtcc acgctgagcc 2989801 tgaaaagatc gatccccaat tattcggctc tgagccgtcc ggtttaggat ctttccaaag 2989861 ataataatcc cggtaaggat tgtccttcga cttgcggctt tcagcaaacc aagcatgctc 2989921 atctgatgtg tggttcacga ccaaatccat gacgattttc attccgcgtt tatggacttc 2989981 atcaatcagc tgaaacatat cttcatttgt cccaaacttt tcgtacatgt ttttgtaatc 2990041 gctgatatca tatccgttgt catcctgcgg ggaatcaaat accggggaga gccagatgac 2990101 atccgccccg aggtttttga tgtaatccag cttttgaatc acaccttgca aatctccgaa 2990161 tccatctcca ttggcatcat aaaaactgcg cgggtaaatt tgataaacga cagcttcttt 2990221 ccaccattca ctcattaggc gttctccttt cacatcgtcc ctgtaggaca accggttcct 2990281 cataaacgtt catgtgcagc ggctcgcctt ttacaagctc aaaaataacg cgcttttcgt 2990341 caaccgtcac attgattaat cgatttcgat aattgatgtt gaatgaatat tcgtcccatt 2990401 ctttcggcaa aaacggagca aatgacagcg tctcattcgc ggtgcgcatg cctgcaaagc 2990461 catgaacgat tgccagccag ctacccgtca ttgaagtaat atgcaagcct tcttccgtat 2990521 catgattgta attatcaaga tcaagccttg ctgtgcgctt atataattcg agcgctttct 2990581 tttccagctt gagttcggct gcgagaatcg catggacaga gggcgatagg cttgattcat 2990641 gaacagtcat cggctcataa aattcaaaat ttcgccgttt ttcttccatt gtaaaacggt 2990701 cattaaaaag ataaatgcct tggagaacat ctgcctgctt aataaaattg gagcggagaa 2990761 tcttgtccca tgaccaattc tggtaaagag gccgttccgc tggatctaat tcgtcaactg 2990821 tttgcaggtc tttgtccaag aacgtgtcat gctgaacgaa aatttgcagt tcttcactaa 2990881 atggatagta catgtgctgg atgatttctc tccagacttc caattctact tcctgcacat 2990941 ccagatggcg gcgtttctcc gctgagatac tttcgagact ttgtagagta tactccaacg 2991001 tccaagccgc aatgacattc gtataccaat tgttgttaac gttgttttcg tattcattcg 2991061 gccctgtgac gccatggatc atatacttat tttttcgttt cgagaagtga acacggtcgg 2991121 cccaaaatct gctgactgcc acaagtacgt ctatcccgta ttcttccata tagttacggt 2991181 cgcctgtata attgatataa ttgtagatcg cataacagat cgcgccattg cggtgaattt 2991241 cttcaaaggt gatttcccat tcgttgtggc attcatcacc tgtgaacgtc accatcggat 2991301 aaagtgcccc cttcatcccc aattttgcag cgtttcgttt ggcagcctcc aactgatgat 2991361 agcgatacaa aagcaggttt ttcgtcacct ccggctcggc tgtcgccaaa tacatcggaa 2991421 cggcgtacgc ctcagtatcc caatatgcgg cacctccata tttctcgcca gtaaatcctt 2991481 tcggcccgat attcaaacgg gcatcgcccc cgtaatatgt cgagaataac tgaaagatat 2991541 tgtagcggat tccttgttga agctcctcat ctcctttaat ctcaatgtcc gcttttgccc 2991601 atctttcctt ccatcgatca gtgtgcctcc gttttgcatc ttcatagccg ttctctacca 2991661 catccgccaa aagctccttg gctttcgata aaagctcttc ctcccgaaaa tcacgggaag 2991721 tcgtgacaat cacaaacttt ttcaatgatg ccttcgtttg ataactgtag cgattctcga 2991781 catacatttc agtcgtttta aagctttcat ggacaaaacc ctccgtctcg tttgccattg 2991841 cggctaatac cgtgaagcgc ggtgttccaa atggattttc gatcgttttt gccgctaaat 2991901 ggccgctgtg agaatcagca cctttcgctt cctcctgcca aaactgttct tggtagttag 2991961 aatcttcatt tgccacattt ccatccaggt aaggaacaag cgtaatgaca gcatctcccg 2992021 tcaagcactc cgcttcataa tgaatcgcac agagttcttt tacagcaagg ctaagaaacc 2992081 gctctgacct gattctgacg gttttatctt gaatgcggac aacagcgctt cgccgcagaa 2992141 tcccctcttt catattgagt tctacctcaa ataattcgat tgggttttga tggagatcga 2992201 ttttttcacc gtcaacatat aggcctatgc ccataaagtt catcgcattg atcacttttc 2992261 cgaaatattc tggatacccg tttttccacc agcctactcg cgttttgtcg gggaaccaca 2992321 cgcctgcaat atatgtgcct tggtgactgt cgcctgaata gccttcttca aaattccctc 2992381 tgacccccat atagccattg gcaagagacg tcaggctttc cagcagccgt gtatgctcct 2992441 tattaaatgt atttgttttg attttccatt catcaatctc aaataaccgc tgatttatca 2992501 tcatttcctc ccgaatgtaa gtttccatta tcacggcggg ttttggtcaa atatctaaat 2992561 gcaaaagaga tcatcaaagt aacgccacac gaatggatca tcaatacagt aatcaaatca 2992621 aaatgaacca tgccgatagc agctgccgca aatgccggca gtgctgatgc gcaaatcgct 2992681 atagaggccg cttccttgaa tgatgcaata gagaccatgt ttgatatttt tgtgatccag 2992741 aggccacctg caagaacaaa cgttaacaaa agctggatca tagaaaccac cgtatatgcc 2992801 agcatcatga tcatcggctt atactgtgcc aaccacaatg tatcgatcaa gacctctaca 2992861 tcatggacgt ttggtttctc gagcttaacg tccattttcg catagccaac agaaaacccc 2992921 gtttcgtttt gatcggtgat caccagttga tcaggttgaa atatgatggc gttttcaaat 2992981 ccagttactt tcaatcgccc attttcaccg cttgtctcat attcatgctt catatcgact 2993041 gccatcacat tctgcccatc ttcaatcctc tcagagctct tcccgcctgt tagttttccg 2993101 ttcctgattt gaaaaccctg caattgatca gcaaattgat cattaactcc ttgaatcgct 2993161 gacggcatga aagatgaaac gctgaagcga tccattttca caaacgaaac cgctaacggc 2993221 gccattaagc aggccgttaa aaacagaaag agaaaagaga gctgcagcca gctgaaggta 2993281 ttcccatagc ggcaaacacc tgatggggat gcagccgcct tcaggcagcg gatgataaag 2993341 cttttattct ccagattctt cattggcatt acccctttgt tccgccggct gtcaaaccgg 2993401 acacaaagtt cttttggaga aaaaagaata gaacgcatat cggcagtgcg gctagtatgg 2993461 caccggctgc aaatagagct actttttgct gctgcggatt agaaataaag gattgtaatc 2993521 ctacagcgat ggtcagcctt tccggtgagc gaagcagaaa tttcgtcagc aaatagtcgc 2993581 caaacggtgc cataaacgcc caaagcgctt gtaccgcgag cattggctta acaagcggta 2993641 gaacaattga agcgaaaatc ctcagatgtc ccgctccgtc aattcgcgcg gcttcatcaa 2993701 tttctctcgg cacagtatca aaataacctt tcatcagcca cgtgttcatc ggaattccgc 2993761 cgccgatata gatcgctgtt aaaaaccagt attgatcgag tgcgcctatt agcatcgcca 2993821 agacataaaa agcagtcagc gccgccattg tcggcaccat ttgaatgatt aaaaagaata 2993881 tcaggctctt ttttctgcct gcaaaccgat agcggctgta cgagtacccg gcaagtgtca 2993941 caatcgtaac ctgcaaaacc atgaccgata gcgcgatgac aagtgtattg ctgtaccaat 2994001 tgagataaag cgtttcgtca aatagccgct taaaatgatc caatgtccaa gaacccgaaa 2994061 aatcgagctg aaaagccgcc gaattcccca cacggaaggc tgatgatgcc gtaatcagca 2994121 acggatatat aatgacaata cttaaaagcg tcaaaaataa atacgtacag attttattaa 2994181 gcattctggc agtgctcgcg ttcacctaca taacctcctc attgccaaaa gcattcgatt 2994241 ttttgaaagc aatcagtgaa attccaatga caatgaaaga aattaacagt gtcacagccg 2994301 ccgcaacgga atattggggt gatgtgcctg ttgtcagttt ataaatccac gaaattaaga 2994361 tatcggtcga tccggccccg gctcccgcac tgcctggccc tccctcatta aataaataga 2994421 tgatcgagaa attattgaaa ttaaacgtat actgagtaat catcacgggt gctgtggcaa 2994481 ataaaatcat cgggaatgta atatgccgaa aacgctgaat aaaagtggcc ccgtcaatct 2994541 ttgccgcttc atacaattca cctggaatcg cctgaagcac tcccgttacc atgacatata 2994601 tatatggaaa gccgagccac gtttgaatca taatgagggc tgtctttgtc cagaaaggat 2994661 cggtcttcca cgcgatcgca ggcagctcga caaacggcag gtgattgaat aatggtatca 2994721 cctgtgcatt caccgctcct atgctgtcgt taaacatgtt ggaaaaactc atgattgtaa 2994781 taaacgccgg aacagcccat ggaaataaga aaatcattcg aaatatccgc ttgcctttta 2994841 taaaatcctg attgacgaaa agtgccgtca caatacctaa aatgatttgc agcgttgttg 2994901 cacagattgt ccagataacc gtccagccca gtacattcac aaatgtttca cgataggagc 2994961 caaggaaaaa aatatttaag aaatttttaa acccgaccca gtcaatcaga cgattaggcg 2995021 gaatatgata aaaatcatag tttgttaatg caacaaacag agtcaccaaa accggaaaaa 2995081 taatcacaaa caccatcatg atatatgccg gcagtgtaaa tagatacgga aaacctttat 2995141 cgcccgcatg acagatcata tccttggctg ttgtattgac ttccaaaccc gccgctttca 2995201 tagcggcggt cttacgtgaa tcatgaatat taaagatata gaacatgagg aaaatcattg 2995261 tcacgatcaa ttgcagcgtg ccttcaatca gcataaacag cgagtgatct tcaccgggaa 2995321 cacttcccaa tgtcatcaat ccggttagcg cctgtatacc gaaaacgcat aattcaaaag 2995381 caaacaagcc tgtgatggca agaaataaga gcccctttga caactgctga ttcgcaatct 2995441 gcccaagtcc tggaatgatc gataaaagcc ctgcctttcg tttttgcttt gtaagtgtgt 2995501 gatgtttatt catttttccg ccctctattc ttccggacgc tatcccgccg ttttatttca 2995561 catacttttc tttaatattt tcctttatga cgtttacagc atcattcgct gatgtttgtg 2995621 tcgatttttt tcctgaagct gcatcaaaaa ttaaactttc cgctcctgtc catacttcag 2995681 ccatttccgg aatatttgga gtcggcgttg ctgtttcata ttgtttaatc acagctgacg 2995741 tcagttcatt cttttgctca tcggctttct tccttgcagc cgtgttggcc ggaacttcgt 2995801 ttgtatcctc ataaaaagcg taagcattgg catcatttgc agcatactca agccattttt 2995861 cagccagctc gggctctttt gtatatttcg aggcaaccca gcccttcccg ccagcaaaag 2995921 gggcgtattc ttctccattt ggcaatgtcg gaatgggagc cgctccgtag ttcaatttag 2995981 cctctttata gttggcagct gaccaaggac cgccaatgat cgcagccgct ttgccttcta 2996041 aaaacatctg ctgaataaag tcgtctgcgc ttgaattgtc ttgcattcct ttcggccaat 2996101 atgtctcaaa ccatttctcc gcatatttca ccgcttctac agccccttta ttgttcaggc 2996161 cgatgtcccc ggaatctgtg ccgttttttc caaacacata tccgccgtat ccagccaata 2996221 agccgtacga catataaaag tcagtccatt ttgctaaaaa tccggttgat tttccttttt 2996281 ccgaagcaaa cgcgaatcga ggatcttccg ttaacttttc aaggtcttta aatgtttttg 2996341 gcgctgtttt taaaagatct ttgttgtaat acaaaataag tgtctcaatg actagcggca 2996401 ttccgtacac tttgccgtca actgtcacct gctgcatttc tttatcacca aagctttttg 2996461 tgttagatgg cttaatatca agtaaatgtc cttgttgtcc caaaccgccg atccggtcat 2996521 atgcagcaag cataacatca ggcgcattac ccgccgggcc atcaagagga agcgcttcta 2996581 actgttcgaa catttgcttt tcaacaattt ttactgtgac atcattttct ttttcgaact 2996641 ttgtttttat gctttcaatg tattctttat acgtttcttc gacagacaca gtcagcacct 2996701 ttttgccatc agagcttgct ggattttttg aacttgagca ggcggcaagg ccgattgcca 2996761 ggaatgatgc cgccaatatg gcgaacccct tttttaaaag aaccatctct tttcctcctt 2996821 ctatttacga aactataaca attgtattgt cctatagaaa gcggttacaa caactttcga 2996881 tttgttaccg ataacagaat gttatacagg ggcggcagca ctcaaaatca aaaattctcc 2996941 cggctgaacg gcaatgacat cgtgatgctg tagcggctgc tctgtccatg catcacagat 2997001 tttcttattc ctatcaatat tcaactctcg taaactgacg tgttgaacca cattcccttg 2997061 attaaagaaa taaatcagta ttttttcatc aagagtccgc gaaaagctaa tgaaatcatt 2997121 tttgtcgtcc agcagattcc actcaagatg tccttcagtc aataaagtgt tttcctgctt 2997181 gcgtaaagca attaaccgtt tcataaattg cagcatgtct tggttttgct tctctttttc 2997241 ccaaaccata catttccggc ataatggatc attttcgccg ttcagcccga tttccgttcc 2997301 gtaataaatg catggtgagc ctgtctgggc aaacataaag gccagcaacg cgcgtgcttt 2997361 cttctcatca ttgcggcatc tggtcaaaag gcgctttgta tcatggctat ccagtaaatt 2997421 aaacatcacc tcattggcct gcttcattcc attcatcaaa tgtgcattga cacggtgagc 2997481 catacgtgaa gctgagatcg tctggtcagc aaagtattca atcataggct ctgtaaaagg 2997541 gtaattcatc gccgcatgaa attcatcccc tctaagccag ggttcggcag aatgccagat 2997601 ctcacctaaa atataaacat caggcttttc agtagataca gcctgcctaa atgtcttcca 2997661 aaaaacgtga tccacttcat ttgcgacatc caaacgccag ccgtcaatgt caaattcgcg 2997721 aatccagtac aaagcaatat caagcaaata tttctgcacc tcgggattag ccgtgtttag 2997781 cttcggcata tcagctgtaa aagcaaatct gtcataattg tcgtctgtga cgggaaaaga 2997841 gtgaatatgg aaccagtcct tatagcggga ttgatctccg tttttgacga catcctgcca 2997901 ttgcggagac gcgcttccta tatggttaaa aaccgcatca agcataattc tcatcccccg 2997961 ctgatgcagc tggctgacca atgtacgaaa aagctcagga tccccgaaat gcggatcaat 2998021 agaaaagtaa tccagcgtgt cgtatttatg attagaaggc gcggaaaaga tcggtgtcag 2998081 ataaatgccg ttcaccccta aatcctctaa ataatcaagc ttgtcaacaa ttccttgtaa 2998141 atcccctcca aaaaaatcat tgacgtccgg gtccttgctc ccccacggca atgcattctt 2998201 cggtgacaag tcttctcttc catttgcaaa acgctccgga aaaatttgat accaaaccgt 2998261 tgacttgacc cattcaggcg cttgaaatgt atcagcctcg tgaacaaacg gaaatttaaa 2998321 gtaataatga atcgtttcca gtgttttttc gttataaggg catacacccg aacttccgaa 2998381 aaagatgtct tcatgatcgt ctgttacaac aaacgcatat tgtaaacgcc taaatggcgg 2998441 caccacttca gcaaaccaat agtcatgcat ttctgtagca gcaattttcc tcatcggctg 2998501 ctcgtttgcc gaccatttgc cgtcgttgta ctcataggga tcaccccaaa tgaatcgaat 2998561 gtgatctgca tcaccttttt tcgtccgaat cttgatatgc acagtccgcc catcataaga 2998621 ataagcatct gtgctgaatg gctggtgatg aatcgctgca tattccatca tgtttccccc 2998681 tttgatttcc gttttattga agccggctca tagtttgaaa gtatcatgat gaaattgtgg 2998741 gaacaatcct tttcaccctg ttaccgataa cagaataagg cgcttacagc gttgattctc 2998801 gtacaattaa ctctggttca aaaaatagac ttccttgtgc agcgccgtct tcattcattt 2998861 ttttcagcaa cattttcgca caggcttccc ccatttcaac aacaggctgt ctgaccgtag 2998921 tcaagcgcgg cgaggagatg cgatcaagaa acacaccgtc attcccggta accgcaacgt 2998981 cttctggaat tcgctttcca agggattgcg ccgcacgaat gacgccgagc gcgattcgat 2999041 cagatgcgca gacaaatgcg gcctgattgt ccatggattt cagcagttct cttgcaaggc 2999101 attcactttt cttagaactg ttgtcgatcc gaaacatatt cgatttttta aagcttttat 2999161 tcatcgcccg tatatacccc tgttctcttg cacgttcgaa aggctcatct aaatcaatgc 2999221 caaaaaagac aacttcccgc tcccccagcc ccataacatg gcgggttgcc ataaaagtgc 2999281 ctttctcgtt attcacatcg ataaagtcat agcccatttc attttgtcca aatacgacga 2999341 gcggcttctc aaaagctttt attacacctt caaaatcgtt ctttctcaag ccggtggcaa 2999401 taatgccgtc acattggcca atattaagag aatttcttgt cacaagctgg agagcatagt 2999461 gattgcgatc cagctccctg ctgattcctg tcagcaggtt catgtaatat ggttctgtcg 2999521 tatccatttc ctcaagtatc aatagtttca caacctgtgt tctgttttgc acgagcgctc 2999581 tcgccgcata attagggatg taattcagct ctttcatcgc agaatgaaca agctttttca 2999641 attcatccgt caccgtctca gggtgattga tcactcgtga taccgtcatt ttcgaaacat 2999701 ttgctttttt cgccacatct gacaatgttg ccattttcat cccctcctta tctgtgctta 2999761 ttatccaaac tagtgataaa gtcctctatt actgctaaat atacgatgca ggccaaagag 2999821 aaataaaaaa gagatttccc ttaaggaaac ctcactttgt taaaaacact cgatttttca 2999881 tggattcata cgctaggtgg cagactcatt ctctccactt ccatcagaaa atctcttttt 2999941 taaatttctg tccacttttt ttctaaaatc ggataagaat aattttgcat ttgctcaatt 3000001 aactcatccg gccgtgacga gctgtgaatc agttttaggt gcgattcgtt agaaaaccct 3000061 tcttgaatgc tgtatttcac cattttcatc attggttcaa aatatccgtt tacattgtac 3000121 agtccaattg gcttttggtg gatgccgatc tgtgcccagc acagcacttc aaataattct 3000181 tcatatgtac cgaagccgcc cggcatcgag ataaagccgt ccgccagctc gctcatttta 3000241 gcctttcgtt catgcatccc gtttacttca atcagctcag tcagattctg atggacaacc 3000301 tccccgctga acaaaccgct cggcatgacc ccgattgcag ttccgccgtt ttccataatc 3000361 gcgtcagcaa tcgtgcccat caagcctacg cgggagcccc catagacaag gccgattccc 3000421 tgctcagcca tatacacgcc aagctctgcc gcttttcttt tatacgcttc atttccccca 3000481 gggtttgatc ccgcaaatac acaaatggtt ttcatcttgt catctccgca tctatatatc 3000541 gtgttaaaca ttcaaaaaca cactatatat tgtcccatct tcatgtgata atatcaatat 3000601 gaaatacata aagaatgcag gagtgatgag gttgcagctg gctgatgcag aaaaatggat 3000661 gaaagagttt tacgaaaaaa gaggctggac agaatacgga ccttttattc gcgtcggctt 3000721 tttaatggag gaagccggag aactggcccg ggctgtcagg gcgtatgaaa tcggcagaga 3000781 ccggccggat gagaaagaat cgtcacgcgc tgagcaaaaa caagaattga ttgaagaaat 3000841 gggagatgtc atcggaaata tcgccattct tgctgatatg tatggtgtct ctttagaaga 3000901 cgtcatgaag gcccaccaag aaaaactgac aaaacgattt gagcatgcat aaaaaagcgg 3000961 ccgcgatggc cgcttttttt aacctgtgat ttcatcatgg tgatcaaaga aatgctgctt 3001021 tcctattttg tgaaaaaggc ctgttttatg cagtagctcc ttcggctgcg attgcaatcc 3001081 tacaatcatc agctttccat tgtggcgttt aattcgattc ataatgttcc caagcaccgc 3001141 ttcagctgac gtatccatat agtgcacctt attcatgagc agaataaggg ttttcggttt 3001201 tttctgtaca tgctccagca atgacgattc aagggaatca attgatccga aaaacagcgg 3001261 cccttctatg gcatacatgc tgacagatgg atcttctctc ttcgccagaa caggatgcgt 3001321 ttcctgattg tggatgcggg tcgcttcgct cattcttctg ataaagaaca cgaatgcaag 3001381 cagcaatccg gttgccacac cgatgattaa gtcaaacaga accgtaaggg cgaaggtcgc 3001441 cgccaaaata aaggaatcag catttttcag tctcagcatg tttgcgactt ccttgcgctc 3001501 actcatattc catgcgacca ccatgagaat cggtgccata ctggcgagcg gcacatggga 3001561 cgcataaggc gcaaatacaa gcaggacaag gagaacgact acgccgtgaa cgacgccgga 3001621 aactggggaa accgctccgt tttttatatt ggtcgccgtt ctcgcaatcg ctcctgtagc 3001681 cgggattccg ccaaacaggg gcgctgccat attcgcaatc ccctggccga caagctcctt 3001741 gttgctgtca tgctttgagc ccttcatgtt atcagcgacc attgcggaca aaatcgactc 3001801 aagtcctcca agaagcgcga tgacaagcgc agccggaaac agcataacca ttttatccaa 3001861 agtaagctca ggaaactgaa attccggcaa atggcggggg atttctccat aagttgaccc 3001921 gatcgttgcc atgcggtcag ggaaaaagac aaccgcgacc actgtggaaa taagaagcgc 3001981 caacaaagcg cccggcactt taggcatcac cttggcggat acaagcaaaa tgacgagccc 3002041 gatcacagct gtcaaaatgg catacacgtt aaaggtgccg agctgctgca caatttcaaa 3002101 catgttgtga tgaaagttct catgtttttc aacatttctc aatccgagaa aattagcgat 3002161 ttgttccgta aagatcagca cggcaattcc ggctgtaaaa ccgacgataa cgggtttggg 3002221 cacgaatttc attatttttc cgagcttaaa cagcccaaac agtaccagca tcactcctgc 3002281 cataaacccc gcaatcagca gattttccaa gccgtactgc atgataatgc cgaataaaat 3002341 cgggacaaag gcgcccgtcg gaccgccaat ctgatatttt gatcctccaa acaaagaaat 3002401 acaaatccct gctataacaa cagtgtatag cccatattca ggctcgactc ccgaggcaat 3002461 ggcaaacgcc attcctaaag gaattgccac gacacctact acgatacctg caatcaagtc 3002521 tttctgaaat ttctgcaaat tgtatccctt gaatctccct gagaatcgca tattttgtta 3002581 taacctccct tatgagtgat tgtttataag ctcagtttca taaccgttaa tgaccacatc 3002641 aagttttcct gtttcagggt gaatgacaag cccgtgaacc ggcacttttt tcggaagcag 3002701 cggatggttc ttaatcatgt tcacactgtg ggaaacgctt tcttccacgc tgtgaaaacc 3002761 agtcagccac gttttcaaat cgagtccggc actcgtcagc aaattcaggc agctatcctc 3002821 caccccgcgt tcctttgctt tctcaagaat cgaggacgca ttcagccctg acattccgca 3002881 ttcatgatgg ccgacaatgc atacctcttc agcctgcaat tcataaatcg cgaccagtat 3002941 gcttcgcatc acgcttccaa atgggtgaga aacgatggct cccgcgtttt ttacaatttt 3003001 agcatcaccg tttttaagcc ccattgcttg cggaagaagt tctgtaagcc ttgtatccat 3003061 acaggtgaca atgacgagct ttttcgaagg aaactttgtc gttttgtacg gttcatactt 3003121 cttctcactg acaaaccgct gattgtgttc caaaattgat gttaaagaaa ccatttgatt 3003181 catctcccat ccatatgatt ttgcaagcct tcttacccag cttacagtaa ggaattatag 3003241 cataggaata agccaagaaa aggttttcaa aaaaagacac tataattgga ctgtagaatc 3003301 aaaacataaa catttatatc tttcaaagat aataaaattt atatttaatg catcctataa 3003361 tccggctgca gttcgtatat cgatgatttg tctgacaaaa aatatgggtg aattctgata 3003421 attaaaaaac ttttttaagc agatttagct gttcgatctt cattttaagt tcaaaagaac 3003481 cagaaattaa aaaaacgcag ctatattttt aacatctatt tattttcgat ataatgaatt 3003541 agacaacagc cataaagggg gagccttgtt gaaaccattt gtatttatca caaaaccgat 3003601 tcctgaagag attgaagcat tcatcggtga acattgccgt tatgaagtat ggcaggagga 3003661 tacgcttccg agtgacgtgc tatttgaaaa attaaaagaa gcggaggggc ttttaacatc 3003721 agggacgtcc ggaccgtcaa tcaatcgtga gttgctggaa cacgcgccta agctcaaagt 3003781 ggtcagcaac caatcagtag gctacgataa cttcgatata gaagcaatga aagaaagagg 3003841 agtcgtcggg actcatacac cttatacact ggatgacaca gttgcagatc tggctttttc 3003901 actgattctg tcttccgcca gacgtgttgc cgaactggac cgttttgtca gagcaggaaa 3003961 atggggaacc gtggaagagg aagcgctttt cggaattgat gttcatcatc aaacgttagg 3004021 cattatcggc atgggcagaa ttggagaaca agcagcgaga cgcgccaaat ttggttttga 3004081 tatggaagtg ctttatcata accgacatcg caaacaagaa acagaagaca gcatcggcgt 3004141 taagtatgca gagcttgata cattgctgga gcaatctgat tttattcttc tcattacgcc 3004201 gctgactgat gaaacctatc acatgatagg agaacgcgaa tttaagttga tgaagaattc 3004261 agcaattttc gtcaatattt cccggggaaa gacagttgat gaaaaagcac tgattcgcgc 3004321 tcttcaggaa ggctggatca ggggagccgg cttagatgta tacgaaaaag agcctgtcac 3004381 ccaagataat ccgctcctgc agctggataa tgtcacgctg cttcctcata tcggttcagc 3004441 aacagctaaa gtgcgcttca acatgtgcaa acaggccgcc gaaaatatgc tcgcagcgat 3004501 ccaagggcaa acaccgaaaa atcttacaag agaatttcaa taaatcaaaa atccggtctg 3004561 ataacagacc ggatttcata ttacatacgc tgaagaacag cacgcttata aatatgacgg 3004621 gtgacgatat aataaagagc ctggaataca aaataaatga agatgacaat tacggcctca 3004681 agaaataaat tggaattcag catattactt aacgctgcat acgcaaagcc cgcgtgaatc 3004741 gtacctgcga taaatgggat gaagaataaa aatcctattt gctttccaag gatcgagtga 3004801 atctctttgt ccgtaacccc tatcctcttt aacgctaaca cctgcactcc cgtatcttct 3004861 atttccgtaa acatccgcaa atacagcatg cttccttgca cgataaaaaa cagcacgctg 3004921 acaaacagac caataaacag cattaatgca actccctgct tcacaatttg ataactagga 3004981 gcacgtgttt gaaaatcaga tgtatgttct ttcggcacca tgttttcaag cttttcagag 3005041 acatccaccg tctcctgcca atgctcaagc tcataaccta ccattctcat ctgttccttc 3005101 agcggcacat cctgtgacag actgtcaaag ctcttttcgc tgacaaccaa taaacggctg 3005161 actccatcga cagacatcaa tatccctttg ttttgctgct ttttcatgac ataggaaagg 3005221 gtttttcctg acttcatatg aaatgctgct gtttcccctt ctccaaatgt gtctttcacc 3005281 atcatttgaa aagaaacatt aataaatgct tcattttctt gtaaatgaat aactgggaac 3005341 cctttttcct ttgcgacttg attatagact ttttctgaaa tcagcaaagc ttcagcttcc 3005401 atcttcttat ttccatacgg caagtctgac tgaaaagtga caggaatccc tgtggcatcc 3005461 accttatacg tgataacagc atgagctttt ttcaatgtat tctcagccgt ctcaggcttc 3005521 atgacctgaa agcgggaagc atccttttcc acccaggaaa cagactgagg aatgctttgc 3005581 tcctcctgcc tttgtaaatc ggaataaaac atatagatga cacctgtagc tgttagtatg 3005641 accgctgtaa tgacagaggt taaaaacagc atgcgtgcat gatccttcag cctgaatatc 3005701 atgttggaac gcacaatgat atttgtgcct ttgtagaagc tgtgtttctt tcggtacagc 3005761 atgcggaaaa atgccacact gctttgggta aaaaagaaat acgtgccaat taacactaaa 3005821 atcaaaattg gaaaaacccg aaacatcatg tcaattgcat tggctgttgc agatagataa 3005881 taaccgctgc caagacatag caaagacaat acagtgagcc atttcgaata aactggcaaa 3005941 cttttcggct ttttggctga tttaatcagt tcaatgattt ccagcttccg aatccgtccc 3006001 agtgataaaa tgagcagcgt ctgaaacagg atgagaaagc cggcaattgt catcacaaac 3006061 gctttcggca caatggcaaa cgaaatcggc accttcacgc tgagcatcca tgtcatgatc 3006121 ataaaaaaca gttttgaaaa taacaggcct gctccaatgc cggccgcaat cgccgcaaga 3006181 gaaataagtg actgctcata ataaatcatc ttgcgaagct gctgctttga tgtgccaaac 3006241 agtgtcagca gcccaaactc tttctttctt gcctgcaaaa acgctgaatt ggaatatgtg 3006301 atgaaaaata tacaaaacac aatgatgacg acaagagctg cgctcaagca tgttttgaca 3006361 aggcttcctc catatatatt gtcttcattg acatcaggat gaaaaataaa tgatgtgaag 3006421 acaaaaaaca ccgaaacggc aaacacacag cttaaaaagt aggccacata ccgttgcaga 3006481 ttcccaagaa tgtttttacg ggcgatagtt ctcaaattca tgaaaatcgc ctcccaacac 3006541 actcaaggta tccaatatac tttgataaaa cacctgcctg tttgttcctc tgtgaatctc 3006601 tgaaaagaaa cgtccgtctt taataaaaac aatccgttta cagaaacttg ctgctgtggc 3006661 atcatgcgta accaacaaaa tcgtcgcttc cttttcctca ttcagctgag ccagtgtgtt 3006721 catcacttgc tttgccgatt ttgagtcgag gtttcctgtc ggttcatcgg caagaatgag 3006781 cgccggattg tgaataatcg ctctggcaca agctgcccgc tgctgctgtc cgcccgacac 3006841 ctcatatgtg cggtgatcga gaatatgctt tatttgcagc gtatccgcca gttcatccaa 3006901 tcgagcttcc atttctctca gctttacctt atccaatgcg agcggcaaga gaatattttc 3006961 acgaatcgtc agcgtatcaa gcagattaaa atcctgaaag acgaagccga gttctcttct 3007021 gcgaaacaaa gccagctctt ggtcctttaa cgttttcggc tgaatgccgt tgatcatcat 3007081 ctcgccctgg gtcggcttat caatggtagc cagcaaattc aaaagcgtgg tttttccgct 3007141 tcccgacggc cccataatcc cgacaaattc tccttttgac acactgagat caaaggcgct 3007201 gagcgcttgg tatgatattg ttcctttatt tgaatagtat gttttcgata ggttcgttgt 3007261 ttgcaacacg ttcatgttct gctcctcctt tttctttatt ataaaaagga agtcagcatc 3007321 ctcccatcga actttcttgc aattccgctc cccaatctta caatgctgtc acattcacga 3007381 gggtgtcact tgaaaacacg atggtcatca cagtgccagc cccttctttt gattccgcat 3007441 acagcttatg gccgagacgg ctgcacacct gttttgctaa ataaaggccc attccagttg 3007501 cctctttcat ggttcgtccg ttttctccgg taaaaaacgc gtcaaaaatc cgcggcagat 3007561 cctgcggcgg tatgccgatt ccttcgtcgg caaccgacaa gcgcgtctca tgtccctgtg 3007621 tttcaatccg gattgtaata gggtctccca caccttgctt tgaatatttt aaggcgttga 3007681 aaaggatttg ctcaacaaca aaggaaagcc acttttgatc actggaaatc tgaacggcat 3007741 ttggcggcac atgtaatgtt ggaaaaaggc gccgcttgat aaactgacgt ttttcctgat 3007801 tgatcagtga acgaaccatt tctgccaaat caaaggtttg cggctttaca tcaaatgcaa 3007861 attcctccag ccgggccgtt tgcagcatca tatcaagacc gtggcgaaat ctctcattct 3007921 catcctccag ctcctctaaa aacgtcggaa aagaggatga ggttccgttt tttccttcct 3007981 gaatcattaa ggatatgaca gataccggtg ttttcatatg gtggacccat tggttggtga 3008041 aggtgtaatg ctgtttttgc tgattgatat attgtgagag cctgctttcg tattgctgcc 3008101 cgagtgcgtt gatcatcttc gtccaaagcg cttgctctcc tgttcttggc tttctggctt 3008161 tcaaagactg tccgatgtca ttcgaagaag aggcttgttc tgcaagcttt ttaacatatg 3008221 tgagaaagga aaattgccga acataatcag cagcaaaacc tgcggctaaa agagtaccgg 3008281 gcaaaatcca tatgtacatc atattttctt tggaaggttc tgcgccgctc tctacaatgc 3008341 ttaaatacgc aatcagcatg gcggacccta tccctaataa tgaaaataga ataatggcta 3008401 agcggtcgat gagataagtc tttaacattc cgcttcatcc ttccgattga cttgaaattg 3008461 ataaccttgt cctctgattg tggaaatgca atctgtcagt cctgcattct ccagttttct 3008521 ccgcagccga ttgacattga ccgttaacgt attgtcatcg acaaaatcaa cgtcatccca 3008581 taacgcctcc aatagttcat cacgagagac aattttttta tgctccctca caaaaatcga 3008641 gagaagctgg aattcttttt gggaaaacaa aatccggacg ctgttccatt cggcctcatt 3008701 ctgatcagga taaatcgtca gcccgccaag ctccactatt ctagattcct gcggcaaaga 3008761 gggcgaatat tcaccatatg tgcggcgcag gacgcttttg attttggcca tcactacctc 3008821 tagatggaac ggctttgtga tataatcatc gccgccattt tcaatcgcca ttacctgatt 3008881 cagctcatcg gtccgtgccg atataaagat aatcggcgca ttggaaatgg tacggatttg 3008941 cctgcaccaa taaaacccgt caaaaaaagg caggttgata tcaagcagca caagatcagg 3009001 cttcatttct gcaaattcca attttatatc attcagctgt tcagcaattt tcacttcata 3009061 tccgtatttt tgaagatgac cgcccagcaa agaagcaatc cgctcatcat cttccacaag 3009121 caaaatccga tacacgttga tcccccttat atgtacatca cgatgatttt tctagaagat 3009181 tccaaaatta ttatagcatg tgcggaatag taaatcggtc tttttctttt tgttatgata 3009241 gaatgataaa ggtaaaattt tcataatagg caggtgtcgt gatgaagaaa atcatgctgt 3009301 ttctggcaat gacgtcaatt ctttcagcat gtcagcccaa ctataccggg aaatacatag 3009361 aaattgggga tacactaact gactatacca aagagtgctt taaagagaat gaaattcctt 3009421 ataaatacga aaagggaaaa ctgtatatcc cagaagacgc atttgataca gcaatctaca 3009481 cttgttcata agaaaaagct tgcagataac ctgcaagctt ttcacgttac aaaaaatgag 3009541 tatttaattt ctcttcaaat cctgaagggc cgatgtcgct tttttgaatg ttaccgccgt 3009601 tttcataaat cgtaaaatgg cgctctgaca tgaccatcct tccgctcggc gtcagctttg 3009661 aggcaagcag ggatttgtta aaaggagatt tttcatgaga gtgaatgatg tccttcatgt 3009721 tatctaaatc accgagatca ctctcttcaa gggtaaaggc gtacccaatt tgccagcctt 3009781 ctcctttgtc catcagcaga acatagctgc ccttttctgt ctcttccttt ttgattcgga 3009841 atgacccgac tggtgactgt accgtttctc cggaaagcgg tatcggctgg agcgccaggt 3009901 tgatgccgaa gccgatatca acgaggtaat cgccgttttc cgcagacagc catacagcag 3009961 catgcgtccc ttctagtgcc catccctctt gatcgcctgc ataaaccgtt cctcgaatga 3010021 gcttcacatg aaacccggcc tcacgcaaga caaaataaag gaaaccattt agatcgtagc 3010081 ataggccgcc gtgctgatct ttgagcagac gtcgccatag ctcttctttt gtgatcttat 3010141 aattctcttt tgcaagtacg gcacggtttt cgaatggaaa acggtatgcc attgctttaa 3010201 gaaaaagggg aagatcgccg aagctgacat ggtctttctc ccagccgatt ttctgaaagc 3010261 agtcttttag aaagtcactc atttttatca cctaaacttc ttcttgaacg taagcagcca 3010321 gcttctccag cgcctcttgt tcatcttctc cctgggcaat caaggtaacc tcagtgcctg 3010381 tgcttaccgc aaggctcatc agccccatga tgcttttggc gtttactttt ttcccatcct 3010441 tctcaagaaa cacatctgac gtaaaccggt ttgcttcttg tacaaacaaa gcagcaggac 3010501 gtgcttgcag tcctgtcttt aatcgaactt ccactttctg ttgaaccata agatctcccc 3010561 ttttctttac ggttatttta aagtgacggt ttgccctgtc cgcagctgtt ctgcgatttc 3010621 gtcaagtttt ctcagcctgt gattgatccc tgatttgctg attttcccgc ttgctaccat 3010681 ttcccctagc tctttcagcg tcacttcctg ataatcaatc cgcagctgcg caatttcccg 3010741 aagtttttca ggcagcgcct ccaggccgat tctttcatcg atgtatttaa tattttccac 3010801 ctgtctcagc gatgcgccga tcgttttgtt taagttggct gtttcacaat tgacgaggcg 3010861 gttgaccgaa tttctcatgt cccgaacgat tctgacatcc tcaaatcgca gaagcgaatt 3010921 gtgagcgcca attacgttca gaaactctgt aatcttttca gcctctttta aataggtaat 3010981 atagcctttt ttccgttcaa gcgttttgct gtttaactga aactcattta acaggtcaca 3011041 taatgaatcg ttatgctcct tataaagaga gaagatttct aaatgatacg aggaggtttc 3011101 cgggttattg accgaacctc ctgccaaaaa tgctcctctc atataagaac gcttgcagca 3011161 tctctttttg accagctctt tcgaaatact tcgttcaaac acaaaattct ccccgagtat 3011221 ttttaaatcc tctaagatcg cttttgcatt ttctgaaaaa cgcacaatat agacgttatt 3011281 ctttttcagc cgcattttct ttctgaccag cagctcgacc gacacatcat attgtttttt 3011341 cagcaatgta tagatgcggc gggcaatcgc cgcgttttcg gtttgaacat cgagtacgag 3011401 atggcggttt gtaaatgata aagctccatt catccgaatg agtgcagaca gctcggcatt 3011461 aatgcagcag tccttcactt ccagattcgt taattctttt tttgtttctg atgcaaatga 3011521 catatagcca cctcatttca aggcttcatt ctttcagtaa atcaacaaga agagaggcca 3011581 ctttatgtgt atcgtgacgt attacgtcat ttttatacgt tacaatttga tctctgatga 3011641 cttcaagccc catcgctttc agctcttcga tatcaaaatc aacaggacgc gccgattcca 3011701 tttcgtactt acgttttatt tcgtcgggaa tgtcttcact gttcactaat atcgtatcaa 3011761 taaaaccaca gcccatatgc tgattgagcg ctttcacatg atcagcagcg gtgtaatgga 3011821 gcgtttcgcc gggctgagtc atcacgttgc aaatgtatac ttttttcgcc ggcgccttta 3011881 tcacttcttc cccgattttt gggacgagca aattgggaag aatgctggta tagaggcttc 3011941 ccgggccgat aataatcaaa tccgcttccc tgattacgtc tattgtttcc ggcagcggat 3012001 caatctgttc aggcgtgaga aaaacacgct taatgcgctg tccgtattct gggatcgttg 3012061 actcgcctga gaccacgcgg ccatcttcca tctcagcatg caaaacgaca ctggcattgg 3012121 cagccggcaa aacctttcct cttacattca gcaccttgct catttctgtg acagcgtgaa 3012181 aaaaatcacc ggttatattt gtcatcgctg ccaaaatcaa attcccgaga gaatggcctg 3012241 ttaagtcatt ccctttattg aagcggtgct gaaaaagatc ttcaacaagc ggctccacat 3012301 cggataaagc ggcaagcaca tttctgatgt ctccgggagg cggaattttc agttcattcc 3012361 gcagacggcc agagctcccc ccatcatcgg caactgttac aatggccgtg atgtcaacgg 3012421 gtttatgctt taggccccga agcaatacag aaagacctgt accgccgcca aagattgcga 3012481 ttttcggctt ttgtcccatc ttatttccgg cttctctttt caatgtcccg gtgagtaaca 3012541 tgagtatagt aatccttttt gaaataatca gctaaattct cggctaatgt cacagagcgg 3012601 tgctggcccc ctgtgcagcc gatcgcaatg acaacctggc tttttccttc tcttttgtaa 3012661 gatggaagca taaagctcag cagatcaatt aatttctcat tgaacttttg cgtttcattc 3012721 cacttcatga cgtaagagga aacctcttta tccttgccag tcagcggccg catgctttcg 3012781 atatagtacg gattcggcaa aaatctgaca tcaaagacga gatctgcatc aattggaata 3012841 ccgtatttaa aaccaaatga catcacattt acggtaaatg tctctccttg gtttgtcgca 3012901 aagtgcttca cgattttttc acgcaaatca cgcggcttca tgtcagacgt atcgtaaatg 3012961 atttgagagc ggccttttaa ttcctcaagc agctctcgtt ctagcgcgat gccttcaagc 3013021 ggcaggccag tcgctgccag cggatgcgag cgtctcgttt ctttatatct tgtgacgaga 3013081 atggaatcct tcgcgtccag gaataaaatt cgcggtgtga tccacggatt ttcggccatt 3013141 tcatccagcg cttcaatcag ccggtcaaaa aattcgcggc cgcgcaaatc catcacgagc 3013201 gcaactttgc tcattttcga atttgattcc ttcatcagct ctaaaaactt cggaagcaat 3013261 gaaggcggaa gattatcgac gcagaaatag ccgagatctt caaagctttg gatcgcgaca 3013321 gttttccccg ctcccgacat tccagttata atgacaagct gaatatcatg tgattcacta 3013381 acactcatct ttctcccccc tgacttgtct ttctatttga tgtgctgcgg gtctaaacga 3013441 taactgagca gctcaaattc cggtgtatac gtaaatgtgc cgtgcagcag cccttgtccc 3013501 ttcatcataa aatcaaggat atggccgtct ccaggggcca taggcaggtt ctgaatgtca 3013561 ttgacatcgt gccactgcag tttgccttcc tctgattctg atacattttg tcctgtatat 3013621 gaatcagcga caaacgtaaa catcatccac tcggagacaa tgtggtcacc gtctttaata 3013681 ataaaggtaa aaacgccttt taattgagga tttatgatat agataccagt ctcttctctg 3013741 tactctctga tgacggagtc tctgactgat tctccgctct ccatcttgcc tcccggcgcg 3013801 acccaccatc cgcgtctcgg cttttgaagc agaagaactt tgtcatccgt ctgaagcaca 3013861 caatttgtca ctctttgcaa gtacgtcacc taaccttcgt cctgtcatcg tctctttatt 3013921 ataccgcttc aagatgcctc ccacaatgaa gagacattga caatcttttc ttctatttta 3013981 cagcatattc attccttaat tcagatgatt ttgctgtaac tggaattctc ttttatttat 3014041 ggacaaaaaa aggacacgga taactggaga atccgtgcca aaaaagtgta ttcattataa 3014101 aaagggggtc aattacttta ttaatcataa ccgaaaagca ttacacatgt gttacagcgg 3014161 aattaaaacc cagtaacgta atgtgaaact cgtatgacag ccctttttat tttaaggttt 3014221 tcagcgtttc ttggagctct tcgacataat gttgtacgct ttgtgccgca atgcttccgt 3014281 ctcctgtagc cgttacgatt tggcgcagtg atttttcgcg gatgtctccg gcagcgaaaa 3014341 tcccttcaac cttagtttcc atgcggtcgt ttgtttcgat atagccttct tcattcgtaa 3014401 tgcccaggtt ttcaaacggt ttagacagag gaagcatgcc gatgtaaatg aatacgccgt 3014461 ctgttttgaa ttcactttct tcaccggtta ccgtatcgac aagcgttacg ttaccgactt 3014521 tgccgttttc ctcatgaatt tccttcacag ttttgttcca taggaagtca actttttcat 3014581 tatcaaatgc tctcgcttga agaatacttt gagcacggag tttatcacgt ctgtgaacaa 3014641 tcgttacttt tgaagcgaaa cgagtcagat atacgccttc ttcaaccgcg gaatctccgc 3014701 cgccaacaac gacaagttct ttgcctttaa agaaagcgcc gtcacatact gcacaataag 3014761 atacaccgcg tccgcccaat tctttttcgc caggcacgcc gattttttta tattccgcac 3014821 ctgcagcaat gatgacagca cgggctttat attcctttga accagctttg actactttgt 3014881 actctttgcc gtcaatgacc tctttaatat cgccataagc gtattcagcg ccgaattttt 3014941 tcgcgtgttc aaacattttg ttagaaagct caggcccaag gatactttcg aatccaggat 3015001 agttttctac atcttccgta ttggccattt gtccgccagg aattcctctt tcaatcatta 3015061 atgtcgataa attcgctctt gatgtgtata cagcggccgt catcccagca gggcccgcgc 3015121 cgattataat cacgtcataa attttttctt ctgacacact attcactcct taaaccatct 3015181 tttcaagttt gggctctttc ttataagata agaatcccca tcaaacgtat tccttaccca 3015241 tatcctataa aatctcatgg tgatacgcta tttttttgct caacacgatt aaatgtattc 3015301 gaaaagggta tatgttaata aagaaagagc cttctgttta tagaaggccc ttgtcatatt 3015361 tattattgaa caacacgtct tacaacacct ttaaatgctg ctttccagta aggattgctc 3015421 atagagtcaa cagatacgcc atgagatgta ttgtcgttta ggaaagtacc gtttcctaag 3015481 tagattccta cgtgtccatt tgttttgtaa gtgtcaaaga acacaaggtc tccgcgtttc 3015541 atttcagacg cgctgacagc ttgtcctctg ccaactaacg tatcagttgt tgttccgcct 3015601 acaggtccaa ggttaacacc tgcagaagcg tatgcccagc gtacgaatga tgagcagtca 3015661 aaaatacggt tgttgatatc agactgagtg cgtccgccgc caaacttgta cggagattgt 3015721 cctacaatgc ttgaaccaac gctgatcgcg ccttcaattc cgccagagtt gctgataaca 3015781 gtgccgcctg aattgctgtt tgagccgctg ctcttcttag aagatgagcc gtttgacgaa 3015841 ctgtttgatg aaccgttaga agaattgtct gaagaattgt ctgaagaatc atcagatgag 3015901 cttgcttttg atgattcagt tgtcgccgtt tgactgtcat ctgtttgtgt ttcatcagat 3015961 gctttttgtg cttcttcctg ctttttgatc aaagcagccg ctgcttcttg ttcttttttg 3016021 atgcgtgctt gttcagcttc agtatttgct ttttgatttg caagttcaga cgcctctgat 3016081 tttaattcag aaatcgcttt agccgttttc ttttggcttg cttttgcttc gtcgaaaagc 3016141 ttgtcttttt cattaagctg tttatcaagg tctttttgca ttgtttctaa tttagccaag 3016201 gcagcttgaa cttctttcag cttgtcattc aaatccgctt cagaatcttc gagcttcgct 3016261 ttatcctgct cttgctgttt gattaaatct ttgtctgcgt ccacaataga tgaaaccgca 3016321 gtcgcacgag agataaagtc accaaagctt gttgatccta aaagaacatc tatgtatcct 3016381 tgagatccgc cgctttcctg taaagaacga acgcgttttt tcaggatttc attgcgtttt 3016441 tcgatgcgtg cttcagtttc tttaatctct tttttcagtt ttttgatttc ttcttttgtt 3016501 ttatcgtttt cttctttttt atcttcaatc ttgttgcttg tatcaagcgc cttatcgtta 3016561 atgtctttca gttctttttc aatctttgat tgattttcct gaagctcggt taattctttt 3016621 tccttcgctt caatgctgga agcaacctca gattgcttgc tttcgatttt ttgtttcttt 3016681 tcatctaatg tttccgccga tgcagtttta cttgtaaatg ggatcaaaaa actgcttgtc 3016741 ccgatgacgg aagccaaacc aagtgtaatt aaactctttc tcacttttta tatcctccct 3016801 tttactgtga acctgtcctc atttggaatc gtattttgaa catcaagttt cgttcctcat 3016861 actctacgag gaatgatggt tgtttatggt taattattct gtgcatctct tattctggtt 3016921 gtatagcgtt tatttcacat catatgtaaa aaacactaat tccttatgta cgagaatcat 3016981 tataccatca agtttcgaca aattagcgat aaattttatt acatttatgt ttcaaacaga 3017041 tgtcaagtca cacatcattt gtcatttttc ttaagcgtgt aaaaaaactg tcgatattat 3017101 tttcttaata taatctatct aacaaaaaaa gagtcgatta aataaatcaa ctctttaaaa 3017161 tttactattc tagaatatca tcaatatatt tcatatattt cgtcaaagtt gccggagaga 3017221 tgccgaatcg ggccgctgtg tcttttttcg tgtcttgctt gccatgggct tctttccaaa 3017281 tataacagat ggctgctgcc cagcctttct cattcttcaa cggagcagct gcacgaattt 3017341 gctggatgac atgaaaaacc cagcagctca tgacttctgt tttcatctct tctttttcag 3017401 cttgctctaa tagtttgacc gtttgataag cgaaaagtgc atcctctgaa acgtcagcag 3017461 ccgcagaatc tccattcaga agcagcttta caaaatgagt ttcaaaagga gcggtaattc 3017521 tctttgagcg tatcaccgct tcaagatgct ctgtttctcc ctttgtgctg ctgatataat 3017581 aggctgcgag tcgctgctcc acagatgaag gaagagcttc cctccgctca atccaaggcg 3017641 ccgggcggtc ttcgccggga tattgcgact cgacttttct ccagatcgtc tcggcaaagt 3017701 cggtatgtcc cgtaaaataa gcagagcagg aaagccagta aaagaaggtg tcgtcaccct 3017761 caaagccggt tttatataat gatttgagcc atttatatcc gatctcgtag cggccgacaa 3017821 gcgccaaagt agcacccaat ttataacgct gctccaatag catcggatag acattggaga 3017881 gctgatcact caattccgcc actttttcgt cttctctttc ataatagtag aaaacgagaa 3017941 gattgcataa ggcgtgaaga tttccttcat tatgagaaag cacttcataa gcggtttgct 3018001 tcgcttttac aacgtttcct gaatagaaat aggcaagcgc gagattgttg tatgctgacc 3018061 aaagctccgg atattcagtt gtgatttcct caagcgccgc aaccgcttca gcaagctggc 3018121 cgctttccag caatgacttt gcccgatcct gtttcaccag cagttcatcc tgatcataca 3018181 acgaatcctc aatgccgtcg tctcctaaat cgagcaaatc aagcagacta tcgttttctt 3018241 cggcgaattc accatccggg tccgcatcag aataagcggc cgcttcttta taagcttcct 3018301 ggaagagccc cagatgggca aagttattcg ctttaaagta atggcactcc ggcatttcgg 3018361 cctccagatt tgccatgata tagtcaagaa gatcgttcga ctcttgatac tggcccattt 3018421 ccgaataaat gaccgcaagc tgtgaaagca tctctgaatc ctccggctcc aaatgaaccg 3018481 cgcgctgaat cagtttgctt gcccgtttta gattgcgctc tttatacgct ttcaagcctt 3018541 tatgaaaaaa atattgtcca tcttgaagca gctggacaat ttgtgcgtga tttttatgtt 3018601 cagaagtgtg ttttcccaca actaccctcc gttttataca atattaccgt cagtagtata 3018661 ccataaatcg taagcccctc aatagttcaa aaggaaggat tgggaaaatc cctcctcttt 3018721 tttattggct gattcgacca aaatttaccc ggctttgttt tctaagtccg cattcatttt 3018781 cagctgctgt tcagcaaaat cccggtaaag gccatgggaa gccattaact catggtgtgt 3018841 tccacgaccg gtaatttccc ctttttcaac aaacaaaagc tggtccgcat ctacaacggt 3018901 agataggcgg tgagcgataa caatcgttgt gcggccctcc atcagcacct ccagcgcctg 3018961 ctgaactgat ttttcagatt ggctgtcgag acttgaggta gcttcatcga gcataagaat 3019021 gcttgggtta cggagaagcg ctctcgcaat cgcgattctt tgcctttgtc cgcctgacag 3019081 cataatgccg cgttcgccca cttctgtatc aaactgattc ggcagctcct ttataaaatt 3019141 gagcgcatat gccatctccg cggctttttc gatctcagca tccgtcacat ctcgttctaa 3019201 cccgtagcaa atattttctc tgattgtccc ggacattaac gggctttcct gtgatacata 3019261 cccgatatgc tccctccacg attcaagcga gtaagtatcg accggctcgt cccccagccg 3019321 aatggtccct gcagtcggag aataaaagcg ttcaagcagc ttaaacagcg tcgtttttcc 3019381 cccgccgctc ggaccgacga tcgctgtcac tttccctgct tcaatgacgg cgctgacctc 3019441 ttttaagatc agctgatcag gcttatatcc aaaagacacg cgatcaagct ggataggcag 3019501 atgtgcattt tcaatttgtt ttcctgtcac tgtatcttcc tcttcctctg ccaaaatctc 3019561 aatcattcgt tctgttgcac cgattgattt ttgcagctgt gtgaaaaacg ttgtaatctg 3019621 gcccatcggc ataataattt gaaacaaata taaaataaaa gccacgagcg ctccggctgt 3019681 gagctcgcct gatgagacct gcatgccgcc atatccgatc actgcgacaa gcgctgccat 3019741 taacacgagt gaaataagcg ggccgacaag cgattgaacc ttggcttcac gaacgccaag 3019801 cttaaataat gaggaaatcc ccatcttccc gcgcccatat tcgacatcct ccgcatttga 3019861 agccttaaca agtctgattt ccgggagaat ttgattaagc aggcctgtaa aacgagccgt 3019921 ttcatcttgc gtttcccgtg aaatggagaa cattttccgt ccaatcggca ccaaaataag 3019981 agcggccagc ggaacgacca ctaacacaag cagtgtcagc ttccagttca taataaacaa 3020041 gattgtcaat gatccaatga cagaaatgat gcctgtaata aatccgctga tatgggttgt 3020101 aatcaattct ttgaccacca tcgtatcgtt cgttacacgg ctgactgttt ctccggaagc 3020161 atttgtatcg aaataagaga caggcagctt aattaatttc ttccataata actcccgcag 3020221 cccggaaatg attttttgtc cattatagtt aagcgcatag gtggcataag cgcttaaacc 3020281 cgcctgaacg aaaaacacca gcgcgatcaa accgatttgc gtgcctgaca gatttgacat 3020341 agaaaaacca tcgacaagct gcttcgttaa taatggaatg agcaggctga ccagcgtggt 3020401 tactacactg agggcaagcg caaaggcgag ctttccataa gaaggattgg tccgtcttac 3020461 taaggcaaaa aagggtttca atttactttt agatttttgt ttcttggttg gcatatattt 3020521 tcctcctgtt tcagcgttca gaaaggtgaa aagtcatagc aaaaggatga tttttactct 3020581 ttctcaatca tatcaatgga gaaagacttt ttcagtatat ttttgccgtg atcaaaataa 3020641 aaatctccca ctcattgttt gaataggaga tttttgtgtt agacatcttt cactggcttc 3020701 ttttttctgt aagtcaatgt tacatcctgc tgtcgcaggt cttctattat cattttgtac 3020761 cgatcaactt ttgcggtatg ttcttctttt atcatctgaa gggcagcttt tcgtttttcg 3020821 ctattagact caagctcttt ttttattttt tttacaatca accctttttg ccctttgatt 3020881 tcctctttta atgaagactc aaatttcttt gtcaggctga gaaagtcgtt gatcggttga 3020941 ttgagggtgc ccgctttccc cttcatttca tcttgggtaa gaaacatata ggtcgttgat 3021001 acaatttctg tttcactttc tgaaaataag gaagtcactc ttcatattcc tcctaagact 3021061 gaaaatcaaa taactgagaa atcatttctt ctttttcaaa cagcttttca atactctcgc 3021121 ggatattttt gataaaatct cttttttctg ttgtctgttt ttttaattca gcaacaattc 3021181 catcatttgc aggaagcgca cctgtgtgga atgattcatg aactgagatt ttctccaatt 3021241 tatcgaatgt gtggctgaaa ccagctgcaa gccggaattg aagatcgaag gcataatgcg 3021301 aagggttttc ttccatatga tgaatagccg tgatgatcgc ctgctttttg tctatgaagt 3021361 cttcatcgat ttcctgactg taaaccttct ggtacttaga aatcgcatct tccatatctt 3021421 caacgatttt cataccgttt tgatagattc tgacagcgga tgagagattg acttgaatcg 3021481 tttctcccga gccactcttc cctgtaaaat aaatatcgga gcctttatag ctgaagcctt 3021541 tttcctttga caaggcgttg agcatttgaa cgatgctgtg gccgtcgacg ataagtttta 3021601 gtgcgtcttt tgtttctgtg tcgagtgttt tcaatgagga cagaattgat tttacatagt 3021661 ccactatttc accaacgtct tttaaagctt gcataaattg gccatgtttt agatggtcta 3021721 tgaaatgttc gtaccgtgac tctatgcctc gcatactcgc attaatattc gttaattctt 3021781 ttttgatgac tttcttttgc gtttcatcaa tataaccatt ttcagctaac tgatctacga 3021841 ccggtccgct gtttctcaac aaggtatgaa gaaaacctaa aaacgacggc agttcctctt 3021901 ttattcggcc atacatttgc ttaacatcat caaaatgctc atataggaca cttactttct 3021961 ttaaagcgcc gtctgtgttt ttcacttttt caatcaggtc tatgtctatc ccgctggctg 3022021 cctttataaa accgttcaag ccgtcttttt catagtcatc cttatatttt tgaaggaatt 3022081 tttgaattga cctcacatct tcgtcaggaa ccccatccat aatgtttcgg atgcctttta 3022141 cacttgtatt tgtatctgcc atcttcacat caccgaatgt aataaaatcg gccttgccgc 3022201 tgactccata cagcgggtca tcttttgaga tgcgctgagt gatgtttgtt gttacgcctt 3022261 tgtcttcata atatttttgg atttcttttt ttaacttttc tggcgggatg gaatctatat 3022321 cttcatattt ataactaaat ttcctaataa catatctata taaactttca tcagtttcaa 3022381 gtaattgatc aatattgact tgagctccat ttaccccata aacttcatca tattctccat 3022441 caatcaattg caccataact tggttattat ttgcaagtga atgtcctaag gcgaatgttt 3022501 ttaaatcctc agagttacct gctgctttct ttgctttgtt agtaaactcc tttgtagcct 3022561 catactgact atgatcaatt cctaaaaaaa gaccaaaaaa gttatatgac caatccttat 3022621 tatcggcact accttctgaa ataatctgaa gctgatcaat atgttttttc tcatctatta 3022681 tatggattgc cgttccatcg taacctgatt ctctggtcga actttgtata cttgtattct 3022741 gatttacaag ttcattggag gtgtaaattt caattttcat attctcagga agatcgtggt 3022801 gggtttcctc tttataaatt ctgcgtatat ctgcttcgaa atccttctta gctttcttaa 3022861 cttcactcgc aatagttgag gcaaactttt gtttatagtc atattctaaa tcaattaacc 3022921 ttaactttac gttctcattc tcaaatacat ttttatttcc catcttattt ctccttttta 3022981 tctattaaaa aggtgataga attaattaat ttctcaactt tatttttagc cttttcttca 3023041 tctaaggagc atggttgatt ttcatttttg catccaaggg taaaggcgta ttctactcct 3023101 aggttatctt cctctgtaga cttaacatat ccaaaataac tgtatgaata attatatttt 3023161 ctatcaatat cgtcaaagat gtcttttttc ttggcagtgt aaatatccgt tttctttttg 3023221 ctgctttttt tgtattcgcc tttataatca ttttttccac taacaatatc tagcattgtc 3023281 ttaggttcat tcgcaaaact ttcttctttg taatatgtta catggccatc aaacattaca 3023341 ttggtgtctt tatcataact attaaatcca atactttctt tgtttttccc ggttaacgat 3023401 gatcttcttg atagatactt tccatcctcc ggaaacaaca tcctaaaccc tttcagctta 3023461 gattccagca aataatatcc tggttcctct tcttttgttg acaccatgta ctctctcgtt 3023521 ttctcgtcct gaaacgcagg tacttgaggc agatccttgg gatccatgtc ttttggtttt 3023581 accgcttctg ttttattgtc atttgtgctg tttttatcat tgtcattcat actgcatcct 3023641 cctgtcaggg caagtaataa gctgaagcaa ataaagatga tctttttcat tacgaacctc 3023701 cacgggtttt gtgagaatag tattctattt ttatatcaaa aataattcta ttgacctggt 3023761 taagagatga ttatttcatc ctttttcatg ttacatcatg gcggaatttg gataaatagg 3023821 aaatgagact cggttttgat ctccttttat taactaatca tatataacac ccaatataaa 3023881 tctaaatacc tattactttt ttcacaaaac aaaaagagcc gtatcatccg gctctttact 3023941 cttcaatctc agaatggcgt tttttcaata cgtcaagcac atcatccagc ggcagggatt 3024001 gttctctgag caggacaagc aggtgataca gcaggtctgc cgcttcccat ttgagttcct 3024061 catgatcccg gtttttcgcg gcgatgatga cttcggatgc ttcttctccg acttttttca 3024121 aaatcttatc gacgccttca cggaagaggt acgtggtgta agctccttca ggcatttccg 3024181 cttggcgttc cgcgatcacc cgctccagtt cgttcatgat gccgaatcgg tccgcggcct 3024241 gttcttctgt ttgttccttt gtaaaacagc tgtagctgcc agtgtggcat gccgggcctg 3024301 acggttctac gagtacgagc agcgcgtctt gatcgcagtc ataccggata cctttgacgg 3024361 cttgcgtgtt ccctgaggtt tctcctttat gccataacgc ttggcgtgag cggctgtaaa 3024421 accatgtttc cttcgtttcc agcgtttttt cgtacgattc cttgttcata tacgcaagtg 3024481 tcagcacttc tttgcttgcc gcatcctgca cgatagcagg aattaatccg tcctcgttaa 3024541 aacgcagttc atctgcctgt ttcatctcac attcaccccg tactctttca agtatgattt 3024601 cacttcttta atcgatgttt ctttataatg aaaaattgag gcggccagcg cggcgtcggc 3024661 ttctcctttt gtaaaagcct caagcatatg ctgtgcgttt cccgcgcctc ccgaagcgat 3024721 aacagggacg gggacagctt cggaaacaag ctttgtcagc gtgtggtcga aacctttttt 3024781 ctcaccgtcg gagtccatgc ttgtcagcaa tatttctcct gccccgcgtt tgacgccttc 3024841 ttttgcccac gcggtgacct cccaatctgt tttctttctg ccgccgtgcg tgtagacctt 3024901 atatgtgtca gattctttgt catacttggc atcaatggca agtacgatgc attgagaacc 3024961 gaaaaactcg gctccttctg taatcagctc agggcggaga acagctgccg tgttcaccga 3025021 cactttgtcc gctccggcac gcagtatcgt tttcatatcg ctgagctgat tgatgccgcc 3025081 gccgactgta aacggaatgg caagcttcgc ggcaacctgc tccacaacgt caaccatcgt 3025141 ctttcgtcct tcgtgcgagg cggagatatc aagaaaaaca agttcatccg caccttcccg 3025201 gtcgtacact tcggcgagtt caactgggtc accggcatcc ttcaattcga gaaattgaat 3025261 tcctttgaca acgcgtcctt ctttgacatc aaggcatggg ataatccgtt ttgtgatcat 3025321 ttgcgcttca ccctttcaag cgcctcactc agcgtaaact gattggtata cagcgctttt 3025381 ccgatgatcg ctccagagac gccgtccgcc tcattgcggg cgagagcttc gagatccgcg 3025441 acggagctga ctccgccgga agcgatcacc gatttccccg tttccttagc aagctcgacc 3025501 gtgcttttaa cattggggcc tgacagcatt ccatctgtcg cgatgtcagt aaaaataaag 3025561 acttccgcac cttcattggc tagctctttg cccagttcag ttgccttaag ggttgatgtt 3025621 tcaagccatc cctctgttga aacaaaaccg tttctcgcat ccagtccgat tgcaattttc 3025681 tcgccatatt gtttcagcat ttttttgaca aacggagggt tagaaactgc tgagcttccc 3025741 aggatcaccc gctcgactcc tgctgataaa tattcataga cgtcattttc agaacggatc 3025801 ccaccgccga tttcgacttt caggttcagc ttttgcgcaa tctcaatcac atggcggtca 3025861 ttcactcttt tcccttcttt ggccccgtcg agatcaacga gatggatcca ttcggcaccc 3025921 tctttctcaa ataactcagc catgtcgtac ggtgaatcgc catatatcgt ttccttatta 3025981 taatcccctt gaacaaggcg aacacatttg ccgtttctca tatcaattgc cggatataat 3026041 gtaaaagcac tcattttttc accttctgtt ctgctgccat tttcgtaaat tgggttaaaa 3026101 tagacattcc gaccgtgctg cttttttccg gatgaaattg ggcgccgaag acgtttcttt 3026161 ttccgactac agcaggcact cgtacaccat aatcggcgct tgccagaagc gcgttctcct 3026221 ccatcccgtc aatgtaatag gaatgaacga agtaagcgta gccttgttct gttttagtca 3026281 gcagcggaga ttcattatga aaagaaagac gattccagcc catatgcgga accttcagct 3026341 tgtttccttt ttcatcttct gctttcagcc tgactgcttt tccttttaac agcccgagtc 3026401 ctgaagcggt gccgttttct tcgctttctt caaataaaag ctgcatgccg aggcagatcc 3026461 cgagaagcag ccttccctct gagaccatat cgtgaatcaa ttgatcaagc ttcgtgtagc 3026521 ccaaattgtc catcgcgtct ccaaatgaac cgactcccgg caaaatgaaa gcatcagctt 3026581 ctttcagctc ctccggcttt tcagaaacaa aatacggcac gccgacacgt tcaagcgcct 3026641 ttgagacact gtataaattc cccattccgt aatctatcac gccgatcatt tacagcatcc 3026701 ctttcgttga cggtattcct ttaactcgcg gatcgatcgt tgtcgcttca tcaagcgcac 3026761 gtcccagtgc tttaaaaacg gcttcaatca tgtggtgggt atttgttcca taatgaacga 3026821 tgacgtgcag gttcattcga gcttcgagcg ccagcttcca caaaaattca tgtacaagct 3026881 ccgtatcgaa agttccgact ttagcagccg ggaaatcagc gcgcatttct aagtgcggcc 3026941 ggttgcttaa atcaatcaca acttgagcaa gtgcctcatc catcggcaca aacgccgatc 3027001 cgtagcgttt gattcctttt ttatcgccca acgcttcgag cagcgcctgc cctaagcaga 3027061 tgccgatatc ttcagtcgtg tggtgatcat ctatatcaac atcgcctttt gcgttaatgg 3027121 aaagatcaaa ttggccgtgt ttcgtgaata aatccaacat atgtgtcata aacggcacat 3027181 ctgttttaat atccgcttgt cctccgccgt ctattgtaaa tgccagctca atatctgttt 3027241 cgtttgtttt cctgacgcgt tccgcttttc tcatttagaa atcctccgtt ctctcgcttc 3027301 aattgatctg gcatgggctt ctaacccttc cagtctggca aaagccgcga tgctttcggc 3027361 atgttcttca aaggctgatt gactgtaaga aataatgctc gatttctttt gaaaatcagt 3027421 tacgtttaat ggacttgaaa atctggctgt tccgtttgtc ggaagcacat ggttcggtcc 3027481 ggcaaaataa tcaccgacag gctcagggct gtatctgcct aagaaaattg cacccgcatg 3027541 tttgatactg ccaagcaaag cttccggaga ctgtgttatg atttctaaat gctctggcgc 3027601 gagtgtattg acagtctcaa tcgcttctac cattgtttcc gccacatata tacaaccgta 3027661 atctctcact gaagcttccg ctatttctct tcgcggcaag gtttccagct gcttattcac 3027721 ctcggctgaa accgtctcgg ccagcgccat ggaatctgtg acaaacacac atgagctaag 3027781 cttatcgtgt tccgcctgtg acagcagatc ggctgcaatt tcgctcggaa tcgctgtttc 3027841 atcagccagc acgacgattt cactcggtcc ggcaatcata tcgatatcga catcgccgaa 3027901 cacttctcgt ttggcaagcg cgacataaat gttgcccgga cccgtgattt tatccaccgg 3027961 ctcaatggtt tctgttccgt atgctaacgc cgcaatcgcc tgagcgccgc ccattttgta 3028021 aatgtctttt atgcccagct cggctgcagc aaccaaaact ccaggagaca gcagaccgtc 3028081 ttttcccgga ggcgtgacga gaacgattct ttcaacgccc gctacgagcg ccggaatcac 3028141 attcatcaaa acagatgaag gatatgcggc cgttcccccc ggcacatata caccggcgga 3028201 atccagcgcc gtcactttct gccccagcat tgtgccgtcc tttctgtgat aaaaccagga 3028261 ggattgcagc tgtctttcgt gatattccct aatattttcg attgcctgcc taatcacctg 3028321 aagaagacgt gaatccagtg aggtgtatgc ctcctcaaat tcttcttttg tgaccagcgg 3028381 gctgtctatt tcgatgcagt caaatttcgc cgtgtagctg cgaaccgcct gatcaccgtt 3028441 tgctttaaca tcttcaataa tggaccggac cgtctttctt tgctcttccg ttccggcatc 3028501 gatggaacgc ttgagagaaa gccgttccgc tccgctgatg gttttgatct tcattttgcc 3028561 gtctctcctt ccacaacgag agataggcgg gatgccattt cgtcaatcac atcgtctttc 3028621 atgcgatagc ttaccgggtt gacaataaag cgagaggtaa tgtcacaaat gtgctccgtt 3028681 tcaacaagcc cattttcttt cagcgtctgt cctgtggaaa caatgtccac tatccgatct 3028741 gcaagcccaa tgagcggagc cagttcaatt gaaccgttga gcttaataat ctcgacttgt 3028801 tctccctgct ctctgaaata actggaagcc acattcggat actttgtcgc gattcttggc 3028861 gctactccgc tccagtctgt attcggaagt ccggcgacag ctaagtggca tttgctgatg 3028921 tttaaatcca gtacctcata cacatcgcgt tcctcctcca gcatgacatc cttgcccgca 3028981 attccgacgt ctgccacgcc atgctccaca tacgtggtta cgtccatcgg cttcgctaat 3029041 ataaaccgaa gattttcctc cggcacatcg atgatcagtt ttctcgaatc ttcaaactcc 3029101 tcagggagcc tgtagcctgc ctgcctcagc agccctgccg cttcttcaaa tatccggccc 3029161 tttggcatcg ccattgtgag taacttaccc attttgctct tcctttctgg caccgataaa 3029221 ataagtgacg tttgcaaaag attttgtcat ctggtcgata ttttctattc ccgataaatc 3029281 ttgaagaacc actttgttcc ctttcatgcg ttcttcattc gcataagcga tggcttgcgc 3029341 ccgctgctct ttgctgaaaa taacagcgtc tatttcacaa ggttcgtcct tcatatgaag 3029401 ggcttcaatc agccggtcga tccgaagccc gaagcctgtt gccggtgcag gtgaatcaaa 3029461 atggcccagc agcttgttgt aacggccgcc gcttccaatg acaaaaccga cattctcggc 3029521 gtacacttca aataaaatcc ctgtgtaata gctcatgtgg ctgaccatat tcagatccag 3029581 gcggacattt tccgtacatc cgtaatcctc aagaatgtcc cacagcgcct tcagctcatc 3029641 aaccacgctt tttccttgcg cagaatcgac gatttcctcg gcacgtccgc atacttctat 3029701 accgccccgc agttcaagga gctcaagcag cctgctttta tcaatggagg aaagcgggag 3029761 agacttgaca tgctctctgt agccgacgta gttcttttca tataagaacc tccgcagcac 3029821 atcagctcgt tcaacgtttc cgagcacctc aacaaacaaa gcatccgcaa tgccggcatg 3029881 gccaattgca attttaaagg atgccagccc agcgtttttt aatgccccga cgactaaagc 3029941 aatgacctcc gcatccgcgc tcgtcgtgcc gtcaccgatt aactccactc cgacctgctc 3030001 gaactcagcc ggacgtccgc cttcacgctc ctgagccctg aatacatttg ccgcatagcc 3030061 gactcttagc ggatgaccgt gtttcagaag cttcgatgcc gccacccttg caatcggccc 3030121 cgtcatatcc gggcgaagca ccaatgtctt gccgtcctga tcaagtagct taaacagctg 3030181 ctgctcttca attgctgact ggacgccaac ggtatcgtaa aactccagtg tcggcgtttc 3030241 cataaattga tatccccatt tatcaatcaa atcggttaac gatcgtctca cctttttttt 3030301 cgtttcgtat aaaccgggca gtgtatctct catgccgtgc ggtttttcaa acataaacat 3030361 caacccgagc acctccgctg ttatcttatg aaggaaaatt ccgaatcctt tagttcgcta 3030421 atatgataat atgttagcag atgaaagaat gaaaatcaac gcttaacttc agtaaggata 3030481 tttttagttc aaatatcctt ctcctcatta tgaaaaaatc atgaataatg tattaaaggt 3030541 acgtaatatc tcaaattctt tatgtttggc atgctataat acaaatcaaa tagagaacaa 3030601 ggagataaag atgaaaacac tgcgaactct atgtgtcctg atgattcttt caggcgttat 3030661 ttttttcgga cttaaaatag atgcaaaaga tatagatatt ccttttttga acagccttaa 3030721 aaaagtggtt tctgatagcg atacagactc agctgcgaat agcaaaaagg agctgaaggg 3030781 aagcgcaaaa ccgctggatg tcatccttta caatcaaatg gacgcacccc ggctctataa 3030841 cggctgtgaa gtaacaagcc ttgcgatggt gctgaattat gcgggatacg acgtgacaaa 3030901 aaataccctg gcaaatcagg ttgccacagt gcctttgaca tacagcagcg gattaaaggg 3030961 tgatccgaat gacggatttg tcggggatat ggcgaatggc cctggtctcg gtgtctacca 3031021 tcgaccgatc tatcagctgg cgaaaaccta tgcgggagac aaagtgtctg atctgactgg 3031081 aaaaagtatt tccgctgttt atcagcagct tgaaaaaggc aatccagttt gggttattac 3031141 gacagccaac tttacgccag ttgacaacat gcagacatgg aaaacgccaa acggaacgat 3031201 agaaattacg tacagcgaac acagcgtcgc cgttacggga tatgatgata aatatgtgta 3031261 tctcaatgat ccgtatggct ataaaaacag aaaaaccgat agaacaagct ttgaaaaagc 3031321 gtggaaacaa atgggcagcc aggccgtggt tattcaaaag taaacacctg aagcctcact 3031381 atgctctatt ctgagcaaat acgacaatat tcatgctttt tgtatcaatc ggtaagatcg 3031441 attcattttc catttttcac ccaaaattgt ctttactttc aggctgtctg tttttatgat 3031501 taaagcagat tcagccttgc cccgatctat gcgagagaag ccggtgcaag tcgctgacgc 3031561 ttctcttgca aaaaatgaaa gatatccggg gaggatttat cattgaaaaa aatcgtgtct 3031621 atcctattta tgttcggttt ggttatgggt ttcagccagt ttcagccatc aaccgttttt 3031681 gcagctgaca aagtggtgca cgaaacaatt atcgtaccaa aaaatacaac atatgacggg 3031741 aaaggacagc ggtttgtggc agggaaagaa ttaggtgacg gaagccagtc agaaaaccaa 3031801 gaccctgttt ttcgtgtgga ggatggagca accctgaaaa atgtggtgct tggtgcacct 3031861 gcagctgatg gcgtgcacac ttatggaaac gttaacattc agaatgtgaa atgggaagat 3031921 gttggtgagg atgcgttaac ggtgaagaag gaaggaaaag tgacgatcga cggcggttct 3031981 gctcaaaaag cgtcagataa gatattccaa atcaataaag ccagtacctt cacagtgaaa 3032041 aatttcacgg cggataatgg cgggaagttc attagacagc ttggtggttc aaccttccac 3032101 gttgatgtga tcatcgacaa gtgcaccatc acaaacatga aggaagcgat attccggacg 3032161 gacagcaaaa caagcacggt cagaatgaca aatacacgct actctaatgt cggtcaaaaa 3032221 tggattggtg ttcagcatat ttacgaaaac aacaacactc aattttaaca aaaaaagtcc 3032281 gctgatgtta ttcagcggac tttttcaatc tttcttgcat ttcttccttc gtatagatga 3032341 tcctcatcgg atttccgccg acaaatgccc cgtcaggcac atccttatgg acaagcgttc 3032401 cggcggacac aactgcgcca tctcctattt tcaccccggg cagaatggtc gtgttggcac 3032461 caatcatcac ttcgtccccg atcagaactt tgccgatccg gtattcgtga atcaaatact 3032521 catgggccag aatggtcgta ttgtacccga tgattgtatt tgttccgact gagatctttt 3032581 ccggaaacat gatatctggc atcaccatga gggcaaagga tgtctgtttt ccaaccttca 3032641 tccgcagaaa tgtgcggtac agccagtttt tcatccctat aaacggcgta tatctcgcaa 3032701 tttgaatgac aatgaaattt ttgacgacct ttaaaaaagg taccgtttga tagacatgcc 3032761 acagtgagtt ggcccccgag accggatgac gatctgtttt tctcacagat tacttcactc 3032821 caacgatttg taatagatca ctcattttct caagcataaa atccggctca tgcttcgcca 3032881 gcatttccgg ccctttaatc gtccatgcga ctcctgccgt ttttgtaccg gcgtttttcc 3032941 ctgccagcac atcatggtaa ttatcaccga ccataatggc ttccgccggc tcgcttccta 3033001 gctgtttcag cgctaacagc acaggctcgg gatcaggctt tgcattcgtc acatcatcaa 3033061 gggtgacaac tgtttcaaag aattcgccga ttcccgtgag cttgaggccc atattgacag 3033121 tatctcttaa ttttgttgtc acaattccta atgtaaagcc ggcttttttt aatgcatcca 3033181 gggtctcata taccgtttca tattcagtga cgagtgaatc atgcatgtca tgattgtacg 3033241 ctctgtacat agcgatcata tcctcgcatt tatcagggtc catcgaagag aacgtatcaa 3033301 aaagagacgg cccgataaat gcaaggacat cttctcgttt atacttgctc ggataataat 3033361 gctccagtgt atgcaaaaag gacgcgataa ttaattcatt cgtattaata agcgttccgt 3033421 ctaaatcaaa cagaatcgtc gttacttgtt tgtcactcat attgcttcct ttccaaccgc 3033481 tgagggtttc cattttttcc acgtgtgcgc aatagccatt gtcagcagaa ctgctgtggt 3033541 gacacgaatc aaaagaagcg gccagaccgg tatgccaagc ggaataaaga caagtgtatc 3033601 ttccacgacc gcgtggcagg caacgagaaa tataaatgcc aatgtcatgt cccgcttgct 3033661 cacgccgtca tcctcgacag ctttgatcat gacacccgct ccgtaggcca gaccaatcgt 3033721 cagtcccgtc accatcgtca tagacgtatt tttattcatg ccaagcagct gcgtaaacgg 3033781 cgacagccac ctggaaaacc gataaagcca gcctaaatct cttaaaaact ggatgataat 3033841 catcagcggg atcactattg ccgccagctg caaaacacca agtccggctt tcgttaatgc 3033901 ttctgccaac attcctagcc agctgtctgg cgccgcgctc ttcgcagcga taaaaccgta 3033961 ctgcgccgtt tcctttccgc catgccaaat gaggttgatg acgatggctg acacagcggc 3034021 caaaccgatg cgcacggcca atatgacgcc aattctgata ccaacctttg cggcaactgt 3034081 cgattcgata atcaagttat gacagaaaga aagcataaca gctaaaataa agacttcttt 3034141 cacagataaa tccaatgtta aaatcccggc aattcccgca tacagattca gcatatttcc 3034201 cagtacaagc ggaatggccg cttcaccaga aagcccgaag agacccatta ccggtgtgat 3034261 cagccgtaca agccaatcca tgacaggggt atgctggagc aaagtgacca atagcgttac 3034321 cgggaaaatc actttaccca gcgtccatgt tgtttgaaaa cctgctgcaa gaccggccag 3034381 aaagatcttc ttcatccctc atcccccttt gttgacgtct actccgcgta ccgctccttc 3034441 gagtatccct tgacgcgtct gaagatgatg gctgccacag ccaaaacaat caatacgatt 3034501 gaaatcacct gagcgatgcg aagtgaatca gtcagcatta agctgtcagt ccgcattcct 3034561 tcaataaagt atcttccgat tgaataccaa atgatataga tcaagaacat ctcgcctcta 3034621 cgcaaattcg ctctgcgcag cagcagtaaa acaatgacgc cgacaaagct ccatagtgat 3034681 tcatataaaa aagtaggatg ataatattgc ccattgatat acatttgatt gatgataaat 3034741 tcaggcaggt gcaggttttc taaaaaggct ctgctgacag cctcgccgtg cgcttcctga 3034801 ttcatgaagt tcccccagcg gccgatcgcc tggccgagca aaatgctggg cgcggcaata 3034861 tccgcaagct tccagaacga aaggtttttc actctcgaaa acacataacc cgttaaaatg 3034921 gcgccgatta atccgccatg aatggcaatg ccgcccttcc aaatcttaat gatttctccc 3034981 ggatgtgccg cataatagtc ccattcaaag gcaacataat aaattcgtgc gcaaataatc 3035041 gcaattggaa tggcaaacag gacaagatca ataaacgtat ctttctgcag cccccgtttt 3035101 tcactttccc tcatcgctat ccacagcccg agcaaagcgc cgagaccgat aatgattccg 3035161 taccagtgga cggctaacgg ccccagctga aatgctatcg gattgagtgg ttctatcgct 3035221 tcattcattt aacgccaact cctattcttc ttgttcaccg tcttcaatga cgtccgccag 3035281 cttgttggta aattgttcag cggcattcag ccccatccgc ttcaatctga agttcattgc 3035341 tgccacttcg atgatgactg caagatttcg gcctgggcgg acgggaatcg tcagttttgt 3035401 aatttctgta tcaatgattt tcatggtctc ttcctcaagt ccgagccggt cgtattgctt 3035461 gccctgctcc cagagttcaa gattcatgac aatcgtgatt cgtttattgc ttctgaccgc 3035521 gccagcgcca aatagcgtca tcacattgat aatgccaagg cccctgatct caagaaggtg 3035581 ctcaattaat tccggagcgt ttcccacaag agtatcctga tcctcctgcc gtatttcaac 3035641 gcaatcatcg gcaacaaggc gatgccctct tttcacaagc tctagcgctg tttcgctttt 3035701 tccgacgccg ctttttcctg tgatcagcac gccgacacca tatatatcga caagaacgcc 3035761 atgaattgct gtggtaggcg ccagcctgct ctcaaggaag ttggttaaac ggcttgacag 3035821 tcttgtcgtt ttcagcggcg atctgaggac aggcacccca tttttctcgg aggcgtcaat 3035881 cagctcctgc gggatgggca tatctctaga aagaataata gctggtgtta catcagtgca 3035941 cagagaatcc attcgctgct ttttctcctc ttcaggaagc tgttcaaaga aagaaagctc 3036001 tgtttttccg agaagctgca cgcgctccct cgggtaatat gtaaaatatc cggcaatttc 3036061 aatacctggt cttgataggt cactcattgt aatcgggcgg ttaattcctt cttctccgct 3036121 gattaattcc aaattgaact gttccattac gtcttttgtg cgaacctttg ccacgatatg 3036181 ttcctcctgt tccgggctgc cccgagcttg ctcacaatac tttcatttta tcactttcgg 3036241 gcttgaacct aaaacagatt ttataaaagg ggggaaaaca cctcagctgg tctagatcac 3036301 tagtctgaaa aagagtaaaa taaaggtatt caaattccag aaaggcggat catctatggc 3036361 agagagtctt cttatcaaag acattgcgat cgtgacagaa aatgaagtaa tcaaaaacgg 3036421 ctatgtcgga atcaatgacg gaaaaatcag cacagtttca acagaacggc ccaaggagcc 3036481 atattcaaaa gagattcaag cacctgcgga ttccgttttg cttcccggca tgattgacat 3036541 tcatatccac ggcggctatg gcgcagatac aatggatgct agcttttcca cgctcgacat 3036601 catgtcgtca agactgcccg aagaaggcac gacgagcttt ttagccacaa cgattaccca 3036661 agagcatggg aacatttctc aagctttggt gaacgcaaga gagtggaaag cggctgaaga 3036721 gtcctcttta ttaggtgcag aactgctcgg cattcattta gagggcccct ttgtttcgcc 3036781 taaaagagcc ggagcgcagc caaaggagtg gattaggcct tcggatgttg agcttttcaa 3036841 aaagtggcag caggaggcgg gcggactgat caaaattgtt acacttgcgc cggaggagga 3036901 tcagcatttt gaactgatcc gccatttgaa agacgaatcg attatcgcat ccatggggca 3036961 cacggatgcc gattccgcat tgctgtcgga tgccgcaaaa gcaggggcga gccatatgac 3037021 tcatctgtac aacgcgatga gcccgtttca tcaccgagag cccggagtga tcggaacggc 3037081 gctggcccat gatgggtttg tgacagagct tatcgccgat ggcattcact cccatccttt 3037141 agctgcaaag cttgcttttt tggcgaaagg cagcagcaag ctcattttaa ttaccgattc 3037201 catgagggca aaaggactga aagacggcgt atatgagttc ggcggccaaa gtgtgacggt 3037261 aagaggacga acagcacttc tttcagacgg aacccttgcc ggttcgatcc tcaaaatgaa 3037321 cgaaggcgca cggcatatgc gtgagtttac aaattgctct tggacggata tagctaatat 3037381 aacttctgaa aacgcggcca aacagctggg catctttgac cgaaaaggca gtgtgactgt 3037441 gggaaaagat gcagatttgg tgattgtcag cagtgattgc gaggtgattc tcaccatttg 3037501 ccgcggaaac attgcattta tatccaagga ggctgaccag atatgaaagt aatggaatgt 3037561 caaacgtatg aagagctaag ccaaatagca gccagaataa cggcagatac aatcaaagaa 3037621 aaacctgatg ctgttctcgg tttagcgacg ggcggcacac cggaaggcac gtatcgccag 3037681 ctgatccgcc tgcaccaaac tgagaatctc tcatttcaaa acatcactac agttaatttg 3037741 gatgagtacg ccggactttc aagcgatgac ccgaacagct atcacttcta tatgaacgac 3037801 cgtttttttc agcatatcga cagcaagcct agccggcatt ttattccgaa tggaaatgca 3037861 gacgatttgg aggccgaatg cagacggtat gaacagctag tcgattccct cggcgacact 3037921 gacattcagc ttctcggcat cggccgaaac ggacacatcg gctttaacga accgggaacg 3037981 tctttcaagt cgcgaactca tgttgtgaca ttaaatgagc aaacccgcca agcgaatgcc 3038041 agatattttc cctccataga cagcgtgccg aaaaaagcac tgacaatggg aattcaaacg 3038101 atactctcaa gcaagcgcat tctgctgctt atttctggaa aaagcaaagc ggaagctgtt 3038161 cgtaagctgt tagaaggaaa cataagcgaa gattttcccg catctgcttt gcacctgcat 3038221 tccgatgtta cggttttgat tgatcgtgaa gccgcgtcat taagaccttg aaaggaacat 3038281 gctgacttat gaatatcaat aaacaatcgc ctattccgat ttactatcag attatggagc 3038341 aattaaaaac ccaaattaag aacggagagc tgcagccgga tatgcctctt ccttctgagc 3038401 gcgaatatgc cgaacaattc gggatcagcc ggatgacagt tcgccaggcg ctttctaatt 3038461 tagttaatga aggcttgctc tatcgcctga aagggcgggg cacctttgtc agcaagccaa 3038521 aaatggaaca agcacttcaa gggctgacaa gctttaccga ggatatgaaa agccgcggga 3038581 tgacaccggg cagcaggctc attgattatc agcttattga ttcaactgag gagctcgcgg 3038641 ctatattagg ctgcgggcac ccctcctcta tccataaaat cactcgggtg cggctggcaa 3038701 atgatattcc gatggcgatt gagtcctcac atattccgtt tgagcttgcg ggtgaattga 3038761 acgaatcgca ttttcagtcg tcgatctatg atcatattga aaggtacaac agcataccga 3038821 tttcccgtgc aaaacaggag cttgagccaa gcgctgccac cacggaagaa gcgaatattc 3038881 ttggtattca aaagggagcg cctgtcctat taattaaacg aacaacatat ctgcagaacg 3038941 gaactgcttt tgagcatgca aaatccgtat acagaggcga ccgttataca tttgtccact 3039001 atatggatcg tctttcataa aaaaagcctc caaccctttt taaggattgg agacatggcg 3039061 aaaatcaaac tggtctggtg ccggacgata tgtttctttt ttcgtcttga acttccagat 3039121 cggtgatttc gttttgccgt taaaactgtc ttccactata atgtaccaat aataaacaga 3039181 ctgcggttca agatgatccc agcggaattc agctgtgtcc ccgctcttca cttgctcccg 3039241 ttttccgagc tcttcattgg tatatacgtt acattcaaaa taatcggttt ccaccttttt 3039301 gattcttggc ttcaaatcaa gcgaaaggga aaattcatcc ttgttgccat aggtatccgt 3039361 atcatagtag ttcttatcct ttacatacgg agagtacgtc gatacgtgca ccatgtcatt 3039421 ggcttggtca aattgaagca aacgcaaata cccttggccg ccttctggcc cgccctgata 3039481 atcggccagc atttgatgca caagacgatc cggtttccca tcaccatcat catccagctc 3039541 atctgttttt ctcatcgcac tatgataatg cccgctcaac accatcacga cattcgggtt 3039601 cggctttacg atttctttga atattttctc tccgattggg cttctgtttc cgctgaccag 3039661 caaatactca tgaaaagcta aaatggccat ccggtcagga tgcttcttca gcacctgatt 3039721 catccacgcg atgtcttcat ccgtaatgcc ccatcccatg tacagcatga tataatcatt 3039781 gccgttgcta gaaatcaggt cataatgtcc gcggttattt ttataggaac cgccataatg 3039841 aaatttttta tcaaaacgat cgctgccaaa atatttgcca aacgccctgt aggagccgtc 3039901 cttatgtccg acatcgtgat tgccggccag cacgccgtaa ggaattccgc tcttatccag 3039961 aacggacatt gaccgatcag cgtttttcca ctgtctgata tcggcggaat catctacaat 3040021 atcacccgtg tggaacacat atttgatatt gagctgcttt tgattatctt ttatccattc 3040081 ggtctgttta tcaaaaatat gcggatagct ttcggcgtaa tactgtgtat cagacatcca 3040141 gacaaatgtg tacatatcct tcgcaggagg aatttcatcc tgtacaatca cattcatttt 3040201 cgactcccgt acaaaatcgg cggcaatcac agacgctttc agcgtaaacg gtttgtcatc 3040261 cttcgcgacg aagctgtcaa caggctgcca ttcgtttgtc cgataattcc aagcatacat 3040321 cgtcaccttt ctccccggca aagaactgcc cttccagact gattctgcca gatcattctc 3040381 atcaattgat ggatcaaccg tcacttcaaa gcgatgataa gggaaaagct ctttgttttc 3040441 tgtcgatact gtttttccat cagcagctga tacccgctcc aattctttat tcgtaaatgg 3040501 ggtctccctt tccggcacaa agcttttcgg cggttcagtc agtgacgcgt gcttaaatat 3040561 tttcacatga ttgcgcgctg tatattgaaa tcccctataa aaaccaacat ccatggcatc 3040621 attcgtcgga tctttcaccc gtacagaaag cttggcctta tgcgtgtcgg cttcgctgtc 3040681 tataacctcc ggctggtccg gatgctctcg ttcggtttta aatatcctct caatcactgt 3040741 tttattgccc gcgagatccg ttgctgtcac ttttagagaa tgttttcccg gcaaaaggtc 3040801 agaagatgac gtatgatatg ggagtgtaat gctttctcca tctaacgacg cctccgcttc 3040861 ctcaattctg ctccatttat catacatatc cgcctgcagg ataaggtttc ctttatacgt 3040921 ttgcccctcg gtgatattcg gctcaatgtg aggtcctgaa ttatctaccc gtacaaccag 3040981 gctgacattt tccttcccgt cgcttgcttg aatatggtga gcgccttcag aaagctttga 3041041 tgtatcccac tccagcagct gtgatgtaaa tagtccgtca ggcagattga actgaaattg 3041101 ccagctttta ttcgagcgct gattatcgcc aataaagagt tccttctcag gagacaccct 3041161 ctgatctctg atcaccgttc catccgataa caccaatcgg gcgtttttga ctaagaagtc 3041221 atcacggttt tcagccgtat caaacggaga caccttcgaa cctgaacgta tcgtaatacg 3041281 ctgcagctgc ttccctttcc gaagcagtgt ctctggcaat ggaacagaat aggtgcggta 3041341 tttatttgtt gtatcatcga acaccttcag cactttgcct tccatcgtta ccgcgttttt 3041401 aaaataaagg ttcgttttcc tcgtatcgaa tgcaaaatat acttcttttt ccatcgcggg 3041461 ctctgtcact tgttttttcc cgtcaatcca tagcttaatg ctgtcagctc gcccttctgt 3041521 cgtggctttg agaaattgag ttcccgacag cgtgtctctg ttttcaatat tcatccgcag 3041581 accgtgcgcc ttgcttgttt gtttaatatc aatcattttg accggcgttc tcgcttcatt 3041641 gatcccgtcc ccggccgcca cataatactc tagctgatcc ttcccgatca attcaggcga 3041701 atacacaata taatggaaga gattatcgtt gcggtctttt tcagcaagaa ttcgcttaaa 3041761 cggtttgttc tcatccgtcc ggtagtaaaa ggccactgtt ttcactaggc ttcggtcccg 3041821 tatgtcagcc cgcagctcaa tgctttcagc agggcggaca ggcttgcggt cagtcaaatc 3041881 ctcaatgacc ggcttttctt tatcgagctt gattttccgt ttctggtcgg gcacctgtgc 3041941 ctgtaatacg gttccgggag acggattctt ttccccgatt gaaatgttca gaagttctgc 3042001 tgttccgttc agtggatact tataaagcac tgatgacagc cggcgcagcg catgtttccg 3042061 ataatgcgca accgaaatgt cctttcctgt attcgttgat atcacaacgg cccgcggcct 3042121 cgtattggcc ataccctctg tctcgtctat caccgcaaga ttttttcctt cttttagttg 3042181 tgtctgataa taacgattga aatccgctga cgtcaattct ggatgcccgg caggcttcag 3042241 ccagacgaca aacgtttcgc cggatggtat caagatcctt tcatcaggtc tccaaatcag 3042301 atcggagtca ggcccttctt ttgggtagcg gtaacggata tggtagtctt taaaatcaat 3042361 cgttctgtca gtcgtattaa aaatctcaat aaattcataa ccgtctgcgc gtcctatatt 3042421 cttcgtatca accgccagct ctgtgatcag aagctccgga atatgggcaa ggtcagcctg 3042481 gtatccttca agcttcagtt tcttcgtctc cgactcaacc cgctgcttcc cattcgacat 3042541 cacaatgtaa tactcaagct cgctgttcca aatcaaacgt ttcggaattt gtgccaaaaa 3042601 cttgcggacc gctccggggg tcgggtccat cggcaccatt ttgtagccca gctcattact 3042661 ttgtttataa aaaagaaagg cggaaaatgc ttgatacgaa ttatcgcgaa cttgagcctc 3042721 aatcattaga ttgcttctca tttcagcttt cacatcaatt tgaggaggat tttcaagcaa 3042781 gggtatgtaa tgaggcgttt gaaatagttc ctgctgtaca acaggaaaag ctttcgattc 3042841 atgatggccg ccagacaaaa cggaaagaaa agacagtaat atagaagcaa taaccgtgta 3042901 tttcctcatc aaagcacctc ccttttcatg tattttgcgt ctgaacaggg aagcttatga 3042961 gttcattttt gtgcataaag aacaaaaaaa cgtctgtctc ttgaaaattc cactattacc 3043021 cagtaaacta aggatagtta accagttaac aattaaatca gagaggcaaa ttgatggaca 3043081 acagcattca tgatgaatta tttcaagcta tacaacaatt cgcattaaaa agggataaac 3043141 gcgtctggca aaaggtgcag ataccatcca ttggcatatc ctcacaacat cacgatcacc 3043201 tcaaaaaaga ctggactttg acccagcttc acattgtttc ctgcatacat accagccaaa 3043261 atgtgaacaa cagcttctta gcatcccgtt tacacatctc aaaagccgct gtttcaaaag 3043321 cggttcatgc tttgttgaaa cacaatatca ttacagtgac aaaaaagcct ggcaacaaaa 3043381 aagaaatttt ttatacgcta actgatagcg gcagaaaatt ggcggcatta catgaacagc 3043441 ttcatgagaa agcaaaggag caatataaac agcttttcaa tgaattttca attgatgatt 3043501 taaaaacagt gactgcgttt ttcaacttgt ggatcaaata tatgtaaaaa gagtctcacc 3043561 cgcatgggag agacctttgg aattctatta tgccccgtca aacgcaacga gaagtgaaac 3043621 aggtccgcgt gtatacagac cggactcagc ataacaaaaa tcttcctcta atctgatatt 3043681 ccgcatctta tccagcacaa tattagctac aatttcgatt tcgtttttgg caaaagctgc 3043741 tcctacacag ttatgaatgc cggatccgaa agcgagatgc cgggcggcgc cgctaaaagc 3043801 gctcttgata ccaagatctt cccgatgaat attaaacacg tcaggctgtt caaatgcttc 3043861 agggtcccgg ttagccgcac cgatcataca aaaaacaatc gtatcttttt tgatttccat 3043921 accgccgacc actgtatctt gggacagctg ccgcggaatc agctgaaccg gcggtttata 3043981 acgcaatgtc tccgcaatgg ctctcggaac taacgaacgg tcagccaaaa catcattcat 3044041 ctgctcagga ttgttgagca aatggtagat catcagtgcc agcgtcttat cagccggttc 3044101 cgttgcggct aacagcacat taagaatcag tgcgagtata tccttgtccg acagcgccat 3044161 gccttcatat tcagaagtac ataggatcga aattaaatct gatcccggat tgacgcgacg 3044221 ttctttaatg accggcatca agtattggga aagctgttcg ctgcaccata acgaatgtgc 3044281 ccgcgcttca ggagattgag agatactcgt gataaaatcg gcaactccgc tgtgccactc 3044341 agagattttt tcatggtctc ttttatccag cccgagcatg tccatcgtga cgcacaccgc 3044401 aaacgtcttt ccaaaatcat tgacgagatc acttttccct ctttcaagat aaggcgctaa 3044461 caagttttct gcattttgtt taatcaatgg agacagatga tccagtgcgt caccgataaa 3044521 gcttctcact acaattcttc ttttggcaga gtgttctttt ccatgcattt gggccagcac 3044581 agggcctcgc atgactggtt cggcacgctc aacaagtgat ttcgtcgtga agatatccgg 3044641 atgctgaagg atatagcgga catcatgata gcggctgata aaataactgt ctatcgactc 3044701 ttcataatga accggatctt cctcccgcag ttgtgaaaaa taagcatatg gattgttttg 3044761 aaattgatca gaaagcacac taaacaattt aatcgattgg ctcatgtttt actcccccta 3044821 tcatccttca gatgtgatcc gtttctcaga aagcatctgc gccatttcct gtacaatgag 3044881 atacccttga ttcggccgca tacaaataga aaattcatgg ttactgatct tctcacccag 3044941 cttccacgga cgatgataag caaggagtgt ctcttccacc tctaaaatat ccggagctcc 3045001 gataaaaaac ggcagctcag ctatgacata ttccacagcc aaattcagca tatcctcact 3045061 gacttcttcc atcatcaaac tgacgccccg cgcacgcccg attatcgctt cacgagacat 3045121 gtccaaacaa gcatgtcgaa aatgaggctg ctcaaaaaat gcatgttcaa cttcttgtct 3045181 caacagctgg taggctttgt tatctataaa atcagaaaat gtatgaatcg ccttcggatc 3045241 cccgccatga gccacaaggg ctctttctgc aaatctcctg tttcgtgata cctctttcct 3045301 tacttttcgt tcagcctttc ctctcggagt tccaagcgct tctagaagat tagccgcctc 3045361 atgccctgca agtaaaactg aaacgctttt aaattgagct ttcgcccatc caattaatct 3045421 gtaaatataa tcctctgaaa acctgctgtt aaatgggctg atccccacca aaacatgcct 3045481 gcgccgttca aatatttctc tgcagttttc tgttaatgcc tcagcaataa aatgcacaga 3045541 ccttctttcc gttaccattc cggtcatctc attcacccct aaaacttatc ccgctttaag 3045601 tcatcaccct caaatacaag atggaatagc tagaacaact gaacaagacg aatggcaggc 3045661 atcacttaaa gtttccaaat gttttttaag attttaataa tcattttcaa tacccatatc 3045721 atgataaatg tttactagta aacattagtc attttatccc ttttccttcc aaacgtcaat 3045781 atgatctgtg cccaaatatt tgaaaataaa tgtaaacatc acattttcca cacacttttt 3045841 acacgcatat tcagcatgac atatcaacaa atagtctaaa caccaacaat tgacaacgaa 3045901 aacaagaaaa gataaaataa aattgttcac cagtaaacga tttgttttat tgtttcatcg 3045961 taaactatta ttcctaagaa agaaggtagc ctatgtctga tttgacaaaa cagatgatat 3046021 acgacatata cgtgagactg ctgcacctta atgaacaaaa agcgaacact tcacttcagc 3046081 aattttttaa ggaggccgca gaagaggatg tagctgaaat tcccaaaaat atgacaagca 3046141 ttcacgtcat tgactgcatc ggccagcatg aacccattaa taatgccgga attgccagaa 3046201 aaatgaactt atcgaaagcg aatgtaacga aaatcagcac aaaactgatc aaggaagaat 3046261 tcattaacag ctatcagctg acagataaca aaaaagaagt ttattttaaa ttaacccgta 3046321 aaggcagacg gattttcgac ttacatgaga aactgcataa aaaaaaggag ctggcttttt 3046381 accaattcct cgattcattt tcacaagaag aacaaaaggc tgtattgaag tttctagagc 3046441 agttgacgtc aacacttgaa gcagaacaaa ccgatgggac tccagacaaa cctgtaaagt 3046501 aaacaaaaag gcggtgtaca ctttggctca tacaaaatca aaggcagtat tgatcttata 3046561 cactgtttgc ttcagtgcat tttttgcatc tttaagccag aacatttatt cacctattct 3046621 tccgatcatt aaagaatcat tccatgtttc cacagctatg gtgaacctgt cagtctcagt 3046681 ttttatgatt gtgacagcaa taatgcaaat tatattagga gcgatcattg attttaaagg 3046741 cgctcggatc gtcttgatta ccggtattct ggcaacggca gcagccagca tcggctgtgc 3046801 ggtgactact gactttacct tgtttctgat attcagaatg atacaggcag ccggttccgc 3046861 agcactgcct cttattgctg ccacaacgat cggacagctg tttacaggaa atgaacgcgg 3046921 gagtgcaatg ggaacgtatc aaatgctcct gtctgtcgca ccggctattg ctccagttct 3046981 aggaggattc ataggcggag cagccggata cgaagggatt ttttggatac ttgcggccat 3047041 ctctatcgtt ttgctggtga caaacagcat cacctttcct aaagattctc caactgaatc 3047101 tatgcagcaa gccaaaggca atgtgttcgc tcattataaa tcaatattta caaatcgaac 3047161 agggaacgtc attttgactt taagttttgt tctctttttc atttattttg cagtaattgt 3047221 ctacctccca atattgctga cagagcatta ccatatagat gtgggtatag caggactgtt 3047281 atatttgccg ctggcgctga gcacgattgc aggtacgttt ctgtttaaaa gaatacaggc 3047341 aaaaatcggg ctgcacacct tgtttatcgg aagcaatgtg attgccgcct gcagcatcat 3047401 tttatttgct gttacacatt ccgtttctct cgttctcatg gctctgacgc tggcactgtt 3047461 tggcatctcg atgggggtta ttcctccctt gtactctaca atgattacta atgaatttga 3047521 gcacaacaga gggagtgcaa tcggaatgtt taactttatc cgatatacag gcatggcagc 3047581 aggtccgatg gtatctgcct acttgctcac aatgatgccg tctgccatgt cctttagcct 3047641 cctaggcctt ggatttgccg cattgagctt ttgccttctt ccgccaatgt tttcgccgca 3047701 gaagcgcacg aaacaaaaaa agcaccacat gtaaaaaagc tgcctttgcg ggcagctttt 3047761 tttatttttt tctaagcggc tctaaaatgc ctttttgaat cagcaaatgg aagaccgaca 3047821 ggataacgga tgcccatatc gctgtgccga agccgtcgat ttgaaagctg tcacccataa 3047881 tggacgcggt catcataagc gtgatggcgt taatcacaaa caagaagagt ccaagcgtca 3047941 ccatggtgac cggcagtgta aatataatta aaagcggttt aatcagcacg tttaagatcg 3048001 ataaaatgag gctggcgata atcgctgccc caatgctgct gatatggatg gagtcaatat 3048061 atccatcaat gacgattaat aacaatgcat tgactaaaat gctgactgcc cattttacca 3048121 tgtcatttca tatccctttc tgacgggacg ataaaaatcc aaatgatata aatgagcaaa 3048181 accggcaaga cacttgtcat aatggctaag atgacagtta tgactctgag gagtgatgcg 3048241 tcccaattga aatattccgc gagacctccg ataacaccgg cgattttctt atttttttct 3048301 gagcgataaa gcttattcat tcgatcacct ctgtgagtac tttagtttga tggcgcctgt 3048361 tagtgattct gagaagacgg tgatgttttg atcatgtgcc tgatttgaag tgaacatcat 3048421 ttctttttga atcgtatcat ttttttcctt cagcatctct acatccatta attcatggga 3048481 cagcgtacca agattgcttt tcagctctgc cttcactgcg agatcgtccg gaattgcaag 3048541 ctctacattt ccagtcgttg tttttgcata aatggagcgg cagtctgatt ctgttacgtt 3048601 aatcgcaata tttccgttaa agctttgaac gtcaatggat tcgcttttcc ctcggagatc 3048661 gatcaatccg ttaatggttt ccgcttctat cgtaccgcag ctgtggcttg cgagcttaat 3048721 ttgcccgttg gccgtttcag ctatggcttt ttcggctgtt aaatacgaga acgacagcac 3048781 gccgtttgtc gttttcgctg agaactcttt tacatgtaaa tgttcccctc tgactggacc 3048841 gttaaacagc ttcacccgaa tcttatcata ctccttctga ggaatataca aagtgacatt 3048901 cgttttcatc gtctttttct cagtacggat aaaaaactta ttacctttga tttcacattc 3048961 aatatgctga agaaatgcgt gtctcgccgc atcctggctg tcagcgcgat ataccttcgc 3049021 ctggcattcc gctctgatat cgtcatcttc ccaagggacg atatttacgc tgccattggc 3049081 aatttgcagc tcaacactgg aaaagtcagt atctttaaat tgaaaaatgt gctgaacatc 3049141 atacgcatgg ccaaagttta aatcaaggtc aacttccttg acctttttca cagcagaatc 3049201 aatccagtca aacagcttgg ctcctaaaga cggtttgccg ctttcttttt ttgccgttgt 3049261 aaatggctct tcctcgtcat gaacgtgaac tgagagcgct gtgattttct cttctttttc 3049321 cttgtagtcg ctgtcaagct tttcaatcag tgtcaaagct tcttgtgctg taagctttcc 3049381 ttcctcaaca agcttaagga ttcgttcctt ttcttgcttc attacgatct cctccccatt 3049441 gtctacttat gctgcacgca ggaccttaat gccctgaatc acattccaaa tgataatgcc 3049501 aatgacaact aagaaataaa taaccgctcc cccgatgatt acaaatacag gaagcaagct 3049561 gtctccatca atcgcaacgg ctccgccaag taaagcaata aaaaggaaca gccagccgac 3049621 aaacggaaca atgtgagaaa taagagagcg tatcgcatgg cgttttgttt ctttctcatt 3049681 tacaacaaaa tatgcgacaa tcggcacaat gattggcgca atgaacacac tgaaataaca 3049741 aagtgatgca ataatagctt gattacggtt caattcattc cacactccta ttgtgaattg 3049801 tccatgacaa aagatcaggg acgttttact tatttatacg tttaaaatct cttcaggttt 3049861 caaattcatt ctttagacat gctccgattt acggaaattg gattttaaaa agttttagaa 3049921 gtagaatctt ccggctatac cgattacaat atgtaaaaag cttacggcaa ccaaggaggc 3049981 tggacaagca atggagaaag atcccagtga ctatacagta acacaagaat cagtgttaaa 3050041 gctgattcag gaacaaaaaa gaatgaatcg tgaaatgatc accgagcttg agcagattca 3050101 cggacccttc ccgatctctc acgatatcca atatataaaa gtgctgctcg acagcagcaa 3050161 cacacatatt gttcaagatt taatgagtgt aagtaagcag ctgtataaga agactttgta 3050221 attgcggaaa acatatcatt cattataact gaaacaaagc taaaggttag atgacaatat 3050281 cttgcctttt ttgttttgaa aaaacaagtg attccctggc tgtcacaaaa tgattgtaac 3050341 aaaaaaagcc tgccggcaca tccagttaat ggactctgtc ggcaagctgt aactatcaga 3050401 aagagatagc cgttcaaaat taacgtaaca attgaagcac gttttgcggc tgttggtttg 3050461 cttgagcaag catcgcttga gaagcttgag aaggaatgtt gttctttgtg aactcgctca 3050521 tttctttcgc catgtcaacg tcacggatac gggactcagc agctgtcagg ttttcagaag 3050581 aagcaccaag gttgttgatt gtgtgctcta gacggttttg taccgcacca agtttagcac 3050641 gttggtttga gacattgttg attgcagtat caatactttc aagttgtgta tcaaaaggag 3050701 tattagcaaa atctgttaca ttaagtgcgt ttactcctaa agcagttgat gacatgctgt 3050761 caatgttaac tgtaagctgc tggccagcat ttgctccaat ttggaaagtg aaaccatcag 3050821 tttcagtacc atctaataac tttttgccgt tgaattcagt acgatttgaa atgccatcaa 3050881 cttcctcaat aagcgcatcc atttcatctt taattgcacc aagatcttct gcttgttgtg 3050941 tacctgtgtt tcctgcttga acagtaagtt cacttctaaa cctattatgc cgtaaagaaa 3051001 aagcttgcct gctaagccca aggatggact tgccgacaag ctgtcccctc ttaacagagg 3051061 gttttaagat gtagctgttt cttttgcttt caagagcgat ttcatgcgtg ttttgtcacg 3051121 ttcgataaca ggctttaaat aacggcctgt atacgattct tcaacttcag tgatttcctc 3051181 aggcgttcca gacgcgacaa tggttccgcc tccggctccg ccttccgggc ccaaatccac 3051241 aatgtaatcg gccgtcttaa tgatatcaag attgtgctca ataaccagta cagtgtctcc 3051301 gttgtctacc aaccgttgca gcacgacaag aagcctggcg atatcgtcga catgcaaacc 3051361 tgtcgtcggc tcatctaaaa tgtagagcgt acgtccggtt gagcgtttgt gcagctctga 3051421 cgcgagcttc acgcgctgcg cttctccgcc tgacaaggtc gtcgccggct ggccgagcgt 3051481 aatataacct aaaccaacat cataaagggt ttggagcttg cgtttgattt tcgggatatt 3051541 ttcaaagaaa gaaagagcat cttcaaccgt catatcaagc acatcagaga tgctttttcc 3051601 tttgtacgtc acttcaagcg tttcacggtt atagcgtttg ccgtgacaca cctcgcatgg 3051661 aacgtatacg tcaggaagga agtgcatttc aattttaata atcccgtctc cgcggcaggc 3051721 ttcacatcgt ccgcccttca cgttgaagct gaaacggcct tttttatagc cgcggacctt 3051781 cgcttcattt gtctgcgcga atacatcacg aatgtcatca aatacaccgg tgtatgtcgc 3051841 agggttggat ctcggcgttc ttccgattgg cgcctggtca atgtcaatga ctttatctaa 3051901 atgatccaaa cctttaatct ctttatggct gccgggcttc gctttcgctt tatgaagctt 3051961 ttgcgccagc gccttatgca aaatttcatt aacgagtgta ctctttcctg aaccggaaac 3052021 acctgtaact gctgtaaacg tcccaagcgg gaacttggca ttcacttttt tcaggttgtt 3052081 ttctgatgca cctttaattt caatgtaacg tccgtccggc tttcttcttt caggaggcaa 3052141 tgggataaac tttttccctg ataaatagct gcccgttaat gaatttggat cttccatcac 3052201 ttcttccggc gtacccgcag atatcacctg tccgccgtga atgccggctc ccggtccaat 3052261 atctattaaa taatctgctg ccatcatcgt gtcctcatca tgttcgacaa caatcagcgt 3052321 gttcccgagg tctctcatat ttttcagagc gctgatcaag cggtcgttat cacgctgatg 3052381 cagaccgata gacggctcat ctaaaatata aagcacaccg gataaacgcg agccaatttg 3052441 agtcgccagc ctgatgcgct gcgcctctcc tccggacaat gtacccgctg ccctgctcaa 3052501 tgtcaggtaa tcgaggccga ctttgtccag aaagcttaag cgctccacaa tttcgcgcaa 3052561 aatcaaattg gcgatctgca tatccttctc agaaagggta agatctttaa agaaggcaag 3052621 tgcgtcggcg acagacagct cggtaatttt cccaatgtgg cggccgtcaa tcagtacggc 3052681 aagcgcctct ttctttaacc gatagccttt gcacgtcgga caagacttct gagacatata 3052741 ctgctccatt tgctcacgta tgaaatcgga gcctgtctcc ttatagcgtc tttcaatgtt 3052801 gcgcaatacg ccttcaaatt gaatttcacc ttcgcggatt tgtccaaaat cattttcata 3052861 tcggaaataa atcaggtcat ccccgctgcc gtacagcact ttatccagtt gatgcttcgg 3052921 caaatctttg accggcacat ccatatcaat cccgtagtgg gtgcagactg cctcaagcag 3052981 ctgaggataa tattgtgagc tgatcggtgt ccaaggggcg accgcattct ccttcaatga 3053041 caaatcttga ttggggatga caagatcggc atccacttca agcttcattc cgagaccgtc 3053101 acacgtcgga cacgccccga acggactgtt aaacgaaaac agacgcggct caagctcacc 3053161 aattgaaaat ccgcagtgcg gacaggcatg atgctcgctg aacatcagct cttcctcacc 3053221 gatgacatcg atcataaccc gtccttcacc taaacgaagc gccgtttcca atgaatctga 3053281 cagccgggct gccacgcctt ctttcacgac aatccggtca atgactacct caatggaatg 3053341 cttcttgttc ttttctaatt cgatatcgtc ggaaagctca gccatctcgc cgtcaattct 3053401 gactctgaca tagccttgtt tcctaatctg ttcaagcact ttgacatgag cgccttttcg 3053461 gcccgagaca atcggcgcca gcacctgaag cttcgtccgt tccgggtatt ccagaattct 3053521 gtccaccatt tgctcgatgg tctgggatgt aatctcaatt ccgtgttccg gacaatgagg 3053581 cttccctact ctcgcatata aaagacgcag ataatcataa atctcagtta ccgtaccgac 3053641 agtagacctc ggattgcggc tcgttgtttt ctgatcaatg ctgatggcgg gagagagccc 3053701 ctcaattgca tccacatccg gcttatccat ttgccctaaa aactggcggg cataggcaga 3053761 cagcgactcg acataccgtc tctgtccttc agcatatatc gtgtcaaagg caagggagga 3053821 tttacctgat ccggacaaac ccgtgacaac gacaagctga tctctcggaa tcgttacatc 3053881 tatatttttc aggttatgcg ccctggctcc cttcacctct atccgatcca tagccatttg 3053941 ttcatcatcc ttccgctttt agctctaaaa gtaaatcgcg aagctccgcg gctctctcaa 3054001 agtcaagcgc cttggcggct tccttcattt catgctccat ctgttcaacg actttctggc 3054061 gttctttctt cgtcattttc gacagcttcg gcgcggcttt tgttttgtat tccgctttat 3054121 cctcagctgc tactgtggca cgaatgacat cgcgaatttc tttatttatc gttttcggcg 3054181 taatgccgtg ctcttcgtta aaccgctcct gctgctcgcg gcggcgtttt gtttcattaa 3054241 tcgcaatttc catagacttc gttattttat cggcgtacat aatgacgcgg ccttccgcat 3054301 ttctcgctgc ccgtccgatg gtctggatca gcgaccgctc cgaacgaagg aaaccttcct 3054361 tatccgcatc caaaatcgca acaagggata cttcgggaat gtccaaacct tccctcagca 3054421 ggttgatgcc gacaagcaca tcgtacttgc caaggcgcag gtcgcggata atttcaatcc 3054481 gttcaagcgt cttgatctca gaatgcagat agtttacttt aatgccgatt tcctttaaat 3054541 aatcggtcag atcctctgac atcttcttcg tcaaagttgt cacaagcacc cgttcattcc 3054601 gctcgattct tgcttgaatt tcgccgatca agtcgtcaat ctgaccttcg attggacgga 3054661 cgtcaataag cgggtcaaga agccccgtcg gacgaatgat ctgttcgacc atttcatctg 3054721 tatgttcaat ctcgtacggc cctggtgttg ctgatacata cacgatattg tgcatatgct 3054781 tttcaaattc ctcaaaacga agcggacggt tatcaagcgc tgatggaagc cggaagccgt 3054841 gatccacgag cacctgtttc cgcgcctggt ctccgttaaa catgccgcgc acctgaggaa 3054901 ttgtcacatg cgactcatcc accacgatca taaaatcgtc tgggaaataa tcaagaagcg 3054961 tatacggcgt tgaacctgga ggccgcagag tcaaatgtct tgaatagttc tcgatgccgg 3055021 agcagaaacc catttcacgc atcatttcaa gatcatatct tgtccgctgc tctaaacgct 3055081 gcgcttcaag gagctttccg ttttcatgca tgaccttcag ctgctcctca agctccttct 3055141 cgatattttg aatcgccttc tccattttct cggcccgcgt tacgaagtgg gatgccggga 3055201 aaatcgcaac atgatctcgg tcgccgagaa tttctcctgt cagcgcatct acttcccgaa 3055261 tccgttcgat ttcgtcaccg aaaaattcaa ctctgacaca atgctcatca cgggatgccg 3055321 gaaagatttc cactacatcc ccgcgcacac gaaatgtacc gcgctgaaag tcgatatcgt 3055381 tgcgggcata ttggatgtct acaagttttc tgagcagctc gttgcgctca atttccattt 3055441 cagtccgcag tgacacgacc atttcccggt attcctcagg cgaaccgagg ccgtatatac 3055501 aagacacact cgcaataata atgacatctc tgcgctcaaa caaagctgat gtggcggagt 3055561 gtctcagttt atcaatttca tcattaatac tagcgtcttt ctctataaat gtatccgttt 3055621 gaggcacata cgcctccggc tgataataat catagtagct gacaaaatac tcgacagcat 3055681 tgttcggaaa aaattccttg aactcactgt aaagctgtcc agcaagggtt ttgttatggg 3055741 caatcacgag agtcggctta ttgacttctt taatcaaatt ggacaccgta aatgttttcc 3055801 cagttcctgt tgcacccagc agagtctgat gcttcttgcc ctcctgaatt cctttcacaa 3055861 gcttttcaat ggctttcggc tgatctccct ggggctgata tttcgagact aactcaaagc 3055921 gatctttcac aaaaataagc ctccgtttct ttaacgaaat cttcctatag atatagtaac 3055981 acaatggaaa gcaaaatcac taaaaatacg aactaaagtt cggtggtttt ttatttccag 3056041 ctgtttttgt gtataaaaaa cctgctttta aaacgtaaaa gcaggtattc agtctttata 3056101 ttcattatgt ccgatttatt cttctttttt ctctgcagct tttttggcca tatacagtcc 3056161 gccagccaca agagacacaa catccaatcc tacaataaaa tacgtttctg tatagccttt 3056221 taaataagag gcaaacagca atgcagctgt taaagcgatc gccacataat gattaaaggt 3056281 gactctagta aatagaacaa caagcataaa agggaaaaac aatgcaaaaa cggcttttgt 3056341 aatcaacaaa aaccctcctc agggattctt catctgatct gattatagta aaaaatgaag 3056401 aatcggacaa tcgtgcattc gctccctcta cttacaccat accccttttc agccaaaatc 3056461 aatcaccata tttgcatttt ggtgccggtc aaaacttatt ccatggtgcc gctgttctaa 3056521 tcagcggcac tttttttatt acatcatcaa gtccgccgcc agattccgag aataaaagaa 3056581 aataggcata cagtaccagt acggccgcat ttttcaggat aatataacca acttaactat 3056641 tcattttatt taggactttc tgcgtttgac agcattttcc tgaaaaccta caattaaatg 3056701 atagtgttta ctatcatttt ttaaacacag gctccgcaat aaaaagacta gagagaaaaa 3056761 caaaatgaat gaagaaaaga ggggtttcaa atatgtattc tgttttattt cgccaggcag 3056821 aagagtccag ccagctggct ggagcaaaag gaatgaattt gattaaattg accaaacacg 3056881 gtcttcctgt tccggacggg tttattattc aaacgaatgc gctcgcacgt tttatggagg 3056941 acaaccagct tcaagagact agtgaaaacg tcgaaggcgg gatcatttcc ggaacatttt 3057001 cggatgagct gaaagatgag ctgactagtt ccttttataa gcttagagaa tcatatcgat 3057061 ccgtagccgt gcgttcttcg tctgcttcgg aagatttaga aggcgcctca ttcgcgggtc 3057121 aatatgaaac ctacttaaat atcaaaacag aggaagagtt tctggctaaa gtgaaagaat 3057181 gctgggcctc atttttttct gggcgggtca gcagctataa gaaaaaaatg aacaatcaaa 3057241 tcgcagagcc gttaatggga atagtcgttc aggggctgat cgattcagaa atgtcaggtg 3057301 ttatcttcag ccgcaaccct gttacccatg atgatagaga gcttttaatc agcgccagct 3057361 acgggttggg tgaagctgtt gtttcaggaa atgttacccc agacacgttc attgttaata 3057421 aatcttcgtt tgagattcag aaagaaatag gtgcaaagga aatctacatg gagtctgcgg 3057481 cagaaggaat tgctgaaaaa gaaacgagtg aagacatgcg cagccgtttt tgccttacag 3057541 atgaacaagt gattgaattg gctgaaatca caaaaaaaac cgaagacctg tacggatatc 3057601 ctgttgatat agaatttgga attgctgatc atcaaatata ccttctgcaa gctcgcccga 3057661 ttacaaccat tgatcaggac aaaaaagcgg cagaagaaaa acgcagcttc atgattaccg 3057721 acactgatat gaatgatttc tggcttaaca tggagtctaa tattgaaggt ccggtgagtc 3057781 cgttattttc atccttcatc gtgccggcat tggaatatgg cttgaagaag agcatgcaaa 3057841 agtttccgat tggtgtagtt gttgatgaag taaaacttta tcgcggacat atttattcca 3057901 aaaaccaagg cggacagcag cctccttctg aagactgcgg caaagagctt ttcccgattt 3057961 tatcggagca tatgtatgac atcatcaatc acacatacct ccctttttac cggacactgg 3058021 accagctcgc acaaactgag cataccgcag aaagcgcact ggaagctttt caaaaactaa 3058081 aggcctttta tctcacggct tatgaagagc actttaatat cgttttcccg caaatccttt 3058141 taacaaacaa actgcaagcg atgtatcagg acattcaagg agagtccgaa aacgctcatt 3058201 tttacgagat gctgacagga aaaatgaaca aatcactgga aacggaccgt tgcttatggc 3058261 tattttctgt ggaagttcag gagaacccga accttctggc catttttgaa aacaacaagc 3058321 ctgaacagct ccaggagaaa ttggaacaaa cagatgaggg aagacacttc ctgaagaacg 3058381 tccatgaatt cttgcaagaa tacggatgga gatctgttaa aagtcatgat ctgattgaac 3058441 aaatctgggt ggaaaatccg tatttcgctc tggccaatat tcaaaattat gtccgtaatg 3058501 gctatcattt tgacaatgaa tttcagaaaa caaaagaaaa acgagagaaa ttatacaatg 3058561 aattcttgga aagcatagaa gatcccggtt tacgcaccga atttgaccgc tattatcaat 3058621 ggacactgaa ctctgcaaat ataaaagatg atcaccactt ttatattgac gccatgctgg 3058681 atgccaaggc gagaatcttt ctgctgaaga taggtgaatt gctggcggaa aacggtgtca 3058741 ttcaagatcg ggaggacctt tggttcttat atgacgacga agtggaacaa gcgcttcttc 3058801 accctgtatc cctgcaagaa aaggctgaaa aacgcagaca gatttttcat gagtatgagc 3058861 tggcccaagc cccggcctac ctcggcaccc cgacaaaaga acagctcaaa gcagctgaag 3058921 aaattgtcgg cgctgtgata gaggatgaaa aaaacacaga gaatcatatt tttggcattg 3058981 cggcatcaag cggcattgcg acaggtccgg tgaaaatcat tcgggacgcc aatgaatttt 3059041 ctcaattcgc gcctggagac gtactcgttt gcaagatgac cacaccgcta tggaccagcc 3059101 tgtttcaaga cgccaaagcg attattacag acacaggcgg cattttgtct cacgctgcga 3059161 ttattgcccg tgaatacggc attccagccg ttctcggcac acgcacggca accgaaagac 3059221 tgcgagacgg tgacatcatc actgttgacg gaagcagcgg caaaatcaca gttgtcagcc 3059281 ggtcctgatg cgtccccctc tttcttatac aagcggggcg ggtgtatact tgtcctgcca 3059341 gtatattcgt gaggtgaaac gtattgagac cgacaaacaa gagaatcctt gatgctgcca 3059401 tgcagctgct cgtcaaaaaa ggatatcgcg caacgactac aaaagaaatt gcagaaaaag 3059461 caaatgtaag tgaagcgacg attttcagga actttaaaaa caaacaagga ctagttgagg 3059521 ctttgctttc tcagcattct tcaaacagag gcagcatttt ggaacaaaca gaaggggatt 3059581 tgtacaaaga cctgcttcat atcggaacct gtctcttgga ggagctcgaa catagaaaag 3059641 atatcattaa aatcagcttt cgtgaaccgg ccatgtttca ggatgtcatt aaccacgtca 3059701 ctgaatatcc ccaatctatg aaacagctat tggttgatta tctcaaaacg atgggtgaga 3059761 aaggggttat tcagacagga aatgaagcgg aacatgccga cgtgttcatg tcgattatct 3059821 tcggttattt cattcaccgt ctccacttag gagaccgggt catatcaatg ccccaggaaa 3059881 aaatgctgga gcatagcaca gctctatttg tcaaaggaat ttctgctgat taactccttg 3059941 gcataataaa aaggaggatc ccaatgagct caagaaaaga atgggcgctg atcgtctcgc 3060001 tattattggg ggccattctg gttcccatta actcaacgat gatcgcggtc gcgctctcat 3060061 ctatttccca tacgtataac gagtccatcg caagcatcac ttgggtggtt accgtttatt 3060121 taatcgtgat ggcagtcaca cagccgattg caggaaagct cggtgacatg tacggcaata 3060181 aaacaatgta cttatgggga gtcggccttt ttctaatcgc atctctaggc tgcgcccttt 3060241 caccgagtct gctcctgtta attgtctttc gggcattgca ggctgtcggc ggggcattgc 3060301 ttacgccaaa cagcattgcc attatccggc atgttgtttc tgaaaaacgc ctaccgaaag 3060361 tgtttggatt tttcggactg ggcgcgggac ttggtgcagc actcgggcct tttatcggct 3060421 ctatactgat tgacagcttc agctggcatt cgattttttg ggtcaacatc ccgttcctcg 3060481 ccattgcttt atttacggca ttaacgatgt ttcctcaata taaagaaaat aaatctgacg 3060541 cgccgctgga tatcatcggc tctctcttgc ttgcaggcag catcgtttcc attatcctgc 3060601 tgacgaaaaa tgaggctcca tggggatata ctgtatacag tgtattgata cttctttttg 3060661 ttccgctttt tttcagaaga gaaaaacgta cccagcaccc catcattgac tttgcactgt 3060721 ttaaaagctc aacctttaca aatgcgaatc tatcagtctt gttaagcaat ttgatgatgt 3060781 atgccgtctt attgattatg ccgttattta tgacgaacca atttgggctt aatacatcta 3060841 acagcgggat ggcgctttct gtattttcga tcttcatgtc agccagcaac tgggtgggcg 3060901 cgcagctcca tcacaaatgg ggagccaaaa aaatcatttt tctttcattt gccatgatgg 3060961 ctggtgcgaa tctattattt ttgctgttaa gcagctcgca ttctgtcttg ttcctcatgc 3061021 tctctcttat ccttggcggg ctcgcttccg gagtcggtct gaccagcatg caggtttcat 3061081 cccttgccac agtagacccc ggtatgtcag gagtggcatc tgggattttc tcgaccttcc 3061141 gttatttcgg aagcatcatt tcatcagcct taattggcct gatttcggga tatcacaccc 3061201 tatttatgat tctctttgct gtatccatca tcggcgtttt tgtttcattg ggcatcaaat 3061261 ctgatgaaac ggcacggata gaaaaaaact cagcgtaaca caaaacagcc cggcatcgca 3061321 tcatcctgcg gtgccgggct gccttttatg atcccgaagc gactgcttcg tcttcacggt 3061381 catcctttac gaagaggatg cccaattcat gatgttctcc ttcataagaa gctcgctggt 3061441 caaaacgaat ttctccattc aaaccgataa tttcaagctt tacatatgca cggttatgct 3061501 gaagcgcttc atagaaatca gaaacgttct taaccggtat gccattgact ttcgttatga 3061561 tttccccgat tttcaattcc agatcctcag ccggcgtatt ggggataatc ccaagcacca 3061621 ttaagccctg atcccttttc gagaaataaa acggagccgc gttatcattc actctttgct 3061681 ttatggacag aaaaatacgc cctaacaaag cggtacagac cgctgcaccc gcaagcggcg 3061741 tccacagtaa gctcgctgca ccgagaactg cgacggcaag accgagaata caaacgcgtt 3061801 tcgctgtgat ccttatactc gtttcaggca gcgatccctg taccctttgt ccaaatccga 3061861 caaagtaagg aatccataga aaatggaatg agccgccggg aaccgtaaac acgggccacc 3061921 agctaaggtg cgattctaaa ccattaccgg gcacgagaag gaacagcggc aaaagccaaa 3061981 cccggtttgc cagctgctgt ccgatcggca aaccgcggct gcttacgaca agtgccggtg 3062041 atgttctcac atgcgcagaa cgataagcaa ccgctccttc agtgataatc agcaaaccta 3062101 gaaacacagc cacagccggc caaacaactg caaatccttg cggaaatctc tccagaaagg 3062161 gctccgcctg atatatttgc agtccaaaac ctatcagcat actcacactg acgatatatg 3062221 cagcagacat ccagtttgcg cgaagagtga acgctgccgc tgcagtgata acggcaataa 3062281 tcgcaagtaa accgagagga atcgatattc cgagtccacc taaaataact gacaaaagaa 3062341 gacctggaat cagtcccttt gtatatgtaa atttcagatc atcataaata tctgctattc 3062401 ttgtatgaaa ggtttttcgt tcccgtttga ttcttacata gccgaaagcc aaggttatga 3062461 tgataaaaaa ccagaaaagc gggtgtaaga agaacaagcc cgcgcttttt aacagttcaa 3062521 ttccccattg aacagacact atctctcacc gcctcaagcc aaacatgtta ctcatattct 3062581 atcaaatatt aaatggcttg gatatcctca ggagagttta tctctcttgc gtcatccaca 3062641 gcgtgacatt cgatagtgaa aaatccttta aatagtggtt tacatccaca tccaataacc 3062701 cgctgattag atgcatcgac ctttttatat ctgtcagatt aattcctaat cgcttatggt 3062761 ttttcattaa gtagttaaaa taatgtttgg cgcattcctc attaatgtca tttactgatt 3062821 cgacattggt gtaattgacc aaatatctgc tgaacagcat aagaagactt agtgcttttg 3062881 tagctgaaaa tgttacgtct tgtgttctgt cttttaattg ttccactaat tcataatatt 3062941 tttttttcac gcacaatact tgccctcttc aattgtgaac ccccattttc tttatacaga 3063001 taagcacggg ccagtataag cagcagtact ggagtgctaa caagcattct cgctaacgtt 3063061 actctttaaa tacctgtcgt tcagctgcca ttaacctgat tactgttctt tttagaacct 3063121 tcttatattg tatgaagtaa acaaagacta ggcaacttgc aaaagtttca ttttaaatgc 3063181 atattaactc gttagaaagt ctctctcata tattgatatc gggtaataac agtcctttat 3063241 aaatgtttat ttgtgaaaat ttttttaatt tcttgtcaaa aactcatttt ttatgtgact 3063301 tatgatccat aatctcttta agcacaaaga aacaggagat gaaataccat ctcctttaat 3063361 tgacaaataa tgatttcaat gctgtttgaa gctgcaaatc atttttttca tctgattttt 3063421 tcttttctat ctgctgattt aatgtctctg cagtgcgagt gtcgatcaca ccggttttat 3063481 tcagcttgtt ttgatcctga aaagccataa ccgctttttt catgtctttg ctgaaatagc 3063541 catcctcacg tcccggatca aagctgagac cttttaacaa tacctgcgca tgcttgacgt 3063601 cttcattgtt catgtccact ttaagcggct ctttcagctg taagggcccg gcggaaaaat 3063661 aatcgggctg cttaatcgca atggtcggtt caattccttt cttatgaatc cagtttccat 3063721 ttggcgtcag ccacttgtaa agcgttaatt tgatgttgct gccgtccccc attggcacag 3063781 cctgttgaac cgttcccttt ccaaaagacg tatcgcctac aacatcataa tggccagctt 3063841 cctttaatgc gccggcaaga atttctgatg cagaggcact tcctttatcc gtaatcacat 3063901 tgacagggta cgctttttta tgggtcaatg ttgaaaaata acgtttttta tctccattgc 3063961 gttcagcaat ctgaatatac ggctgatcct ttgtaacgaa atgcttaaga atttcttcca 3064021 cactttgaag atatccaccc gggttgccgc gtacatcaat gacaagtcct tctatttctt 3064081 ttttctcaag ctccctcagc gcttttgcaa aatcctctgc ggtgtgctca gaaaaagtag 3064141 agatggcaat atatccgaca gaatgcccct gtactttttt ctctgatgca aaaaccgttt 3064201 cgagcggaat ctcagctctc ttgatccgga atgacaactg cttcttcgtt ccaggccgct 3064261 gaatcttcat tgaaacgctg gacccttttt ttcctcttat ttttaacaca gcgtggttta 3064321 aatccttgcc ggccatcgat tctccattga tgctgataat ttcatcatta ggcttcaacc 3064381 cggctttttc cgctggcgat ttcttgaatg gagaaacaat aataattttg ccgtcttcca 3064441 ttccaacctc agccccgatg ccttcaaatg aggaatcaag agaatcagaa aattgcttag 3064501 ctgtctgctt gtccatgtaa acagaataag gatcatttag cgtagacagc attccctgga 3064561 tggctccctc gagcagcttt tctctatcta ctttttctac gtactcattc gaaattaact 3064621 catacgcttt ttcgattttg tccatagctt tatcccgttc agagtcagct tgtgccgtcg 3064681 cgggaactgc tgcagtctgg ggcttatcca tctcaagcag gttgattccc gcatatacac 3064741 cggcgcctcc gaacagcatg ctccctgctg ctatcacagc cattattttt tgattcatcc 3064801 tttactcctc ctgtatgcca gactgtcttt accaaaacct agagatagta tatgtaaagg 3064861 atggagattt catgtaatca tagaagaaaa agaaggcaaa tgaaaagccg tcccgaaaac 3064921 ggaacggctt tttcacttta tactcgcaga aacttgcgga tggaagtcag acttccccat 3064981 actccaatta ctgcgccgat tgcaatcagc actagcgaaa cttggaatac aaatggatta 3065041 taaggaagaa gagagacaaa tgatccttga acctttggaa cgacccatcc gatgacgtat 3065101 tggtaagtgc tcagcaccag tgcaatcgga atcacagaac cgaatacgcc tagcagcaat 3065161 ccttcaagga aaaacggcca gcggataaac cagtttgtcg cgccgacaag cttcatgatt 3065221 tcaatttctt ttcttcttgc gaaaattgta attttaatgg tgttggaaat taagaacatc 3065281 gccgtaaata ccaggccgat aattaacgcg attccgatgt tgcgggaaac gccgaccact 3065341 ttaaacaaac ggctgacctc ttcttttcca taagtgactt tataaacatg atccattttt 3065401 tcgatctttt tcgccacgtt cggcgtatca tgcggatctg tcgttttgac gacaaacgca 3065461 tcattaagcg ggttttcctg atccttcatt gtcagggatt ttccgctgtc accaaaactg 3065521 tcaaccagct ggtcaagctc tttttcttta gatgaaaaag tgacactctg aatgcccttc 3065581 agttccttaa tatcgttctg aagcttgtcc tgtgccttct gatctgcagt cagatcaatc 3065641 agcactttga tttcgacttg tttttctgca ttcgtggcca tgttattcaa attcagcata 3065701 atcactaaaa acacgccgac taaaatcagc gtaacggtta cagcactaat ggatgcaaat 3065761 gtcatccatg tgtttctccc gagagattta aaactctcac gcaagtggcg cccgagaatt 3065821 ttaatcatat gaaccatact cccctcttga ctcatcacgc acaatgatac catcttcgat 3065881 tgcaatgaca cgtttcttca tggtgtttac gatttcttta ttatgtgtcg ccatcacgac 3065941 tgttgtcccg cggttgttaa tttcctccag cgtcttcatg acttcccagg acgtatccgg 3066001 atcaaggttt cctgtcggtt catcagcaat gacaacatca gggttgttca caattgatct 3066061 ggcaatagat acacgctgct gctccccgcc tgaaagctgg tcaggaaatt gtcgcgcttt 3066121 atgcttcagc tgcacgagat caagcacttc aagcacccgt ttcttaatga cagacggctg 3066181 ttctccaatc acttcaaggg caaatgccac attttcaaaa acagtaagtt tcggaagaag 3066241 cttgaaatcc tgaaagacaa cacctatttt gcggcgcacg aaaggaatct ctttttcttt 3066301 aattgtcgcg agatctttat gattgattaa aatttgtcct tttgtcggtt tttcttctct 3066361 gtaaatcatt ttaataaaag tagatttacc tgctccgctc ggaccaacaa catacacaaa 3066421 ctcgccggga tgaatggtaa cagaaatccc attgagtgct tttacgccgt tcggataggc 3066481 tttatatact tccttcatct ctatcatgaa atcacctaat cttttatatc attttatcta 3066541 tcacacggtc atactcttcg aatgcattcg acaatttatg acccattcat ttgtaaaaag 3066601 atgaaaaatc tgaaagttcc ctttttcaat acacttcatt atacgtcaaa tttagacata 3066661 atactattac agtttctttt cattcatatt gtcaaggcat aaaaacatcc ttgccagcac 3066721 tcggcaagga tgtttttatc ttactttttt tctgacagcc atttggcaat aacagcggct 3066781 tcgttatcat ctacaagccc ctttggcata ttgccgcggc cgtttttaat aatgctttca 3066841 attttgtgtt catcgtattt gcctccgacc tcttggagat taggccctga cacaccttct 3066901 aaatccttgc cgtggcagcc tacgcagctt tgctgatata attcttcccc ttcagatgca 3066961 gtggcttccg tcttgctgcc agtgtctgtc ttctcttctt ttgcatcgtt tgatccgcag 3067021 gcagccaaca gaacagaaag cgcaaatcca atcattagta tcgataactt tgatttcatg 3067081 ttgagaagca caactccttt acgatctctt ccatattata acctcgttta agcgcgtttg 3067141 aaaccctcgc ccagcacctc gctcgcgtct gctacaatta caaaagctga ctcatcaatc 3067201 tgtttgacga tttgtttcaa tttggtgaat tcagtttgcc caaccacgca cattaaaatc 3067261 ggacggtcat cgtcagtata tccgccgact gcagaaattt ttgtcacgcc tctgtcaatc 3067321 ttctgtaaga cagcctcctt gacagcctgc tcctgctttg taatgatgag cgccattttt 3067381 gaacgattaa agccgacttg cacaacatca atggttttgc tggacacata gacgccaagc 3067441 atggcatata agccttgctc aatattaaat acaatcatag ccgtaacaac gatcattccg 3067501 tcaatgatgg cgagacactt ccccaatgac agaccggagt acttatgaat gatctgtgca 3067561 gccaaggctg tacctcccgt cgaacctttc cctaagtaca caataccaat tccgatacct 3067621 atcccgacac cgccaaaaat cgccgccagg agttcatgat gagtggcggg ctgaatatcc 3067681 cttgtcagaa acactactag cggcaaaaac acagaacctg caagcgtctt tagtccaaat 3067741 ttcccgccga gcaaaatgac gccagcaata aataaaggga tattaataat ccactgtaca 3067801 tacgctgctt caaaaccata tgattgtaaa atcgtactga tcccgctgac cccgccggcg 3067861 gcaatcttat tcggaagcaa aaatacatta aaggacacgg ccgtaatcgc tgctcctatc 3067921 aatatgtata cataatcccg caaaatccac aatgttttat tccgtacgtc catcatatat 3067981 cctccgtttc ttccaatgct ctccgatagc attttaatcc ttccctgatt agatgtaaat 3068041 aacacccaaa tacagtggta atatgctaaa gcagcagtga aatcaaggat ataagaaata 3068101 aaaaaacaca cccgtatgca tcaggtgtgt ttttcagctt atgaaagctt agaacgcagg 3068161 taggcatcaa taaacgtatc aatgtcacca tccattacag cttgaacgtt ccccatttct 3068221 gtattggtcc gatggtcttt taccatggaa tacggatgga atacataaga acggatttgg 3068281 ctgccccagc cgatttcttt ttgttcaccg cgaatttcat ccagctctgc ctgctgctct 3068341 tcaattctgc gctgatacag cttggccttc agcattttca tggctctttc acggttttta 3068401 atttgtgagc gctccgtttg gcatgtcaca actacgttcg tcggcaagtg agtaatccga 3068461 acggctgaat ccgtcgtatt gacgtgctgt ccgcccgcgc cgcttgcacg gtacgtgtca 3068521 actttaatat cctccgtacg aatatcaata tcaatttcat cgttaaattc aggcatgact 3068581 tcacatgaaa cgaaagatgt gtggcggcgg cctgatgaat caaatggtga gatccgcaca 3068641 agacgatgaa cacctttttc tgctttgaga tacccgtaag cgttgtgtcc tttgatgagc 3068701 aatgtcactg acttgattcc cgcctcgtca cctggaaggt aatcgagagt ctctacttta 3068761 aagccgcggc gctctcccca tcttgtatac attctaagaa gcatagagcc ccagtcctgt 3068821 gactctgtac cgccagcacc agggtgcagt tctaaaatcg cgttattttt atcatacggc 3068881 tcgctgagaa gaagctgaag ctcaaactca ttgaactctt ttgttaatga ctttagttct 3068941 ttttcaagct caagctggag atcagtgtcc ggctcttctt tcaaaagatc atgagtcatt 3069001 tgtaattctt cgtgggattc attcaatttt ttatacgaat tgacataatc ctttaaaccg 3069061 tttgcttcat ttataaccgt ttgagctttt tgctgatcat tccagaattc cggatcagcc 3069121 atttgttcat ctagctcagc aatgcgggcc tcctttgatt cgaggtcaaa gagaccccct 3069181 aaagtccgct aaacgagaag ccatattttc gagctctgct ctaatttctg ataattccat 3069241 ttcattcacc tcattaaaag atccgcaggc gcctgcaggc gccgcggtca gtaaacttgc 3069301 cggggcgaac tattcagtac ggccgcagca atttttatat tttttcccgc ttccgcagtg 3069361 gcatggggca tttcgtccga tatcaaccac tttgcgaacc ggtgctttct ttgctttttt 3069421 gttatcgtcg ccttcttgcg gctgatgagc tgttgtttga ccttgtacaa cctcttcacg 3069481 ctccagattg ttttcaatct cagctttcat cacaaatttt gcgacttcgt cctcaattga 3069541 ttcaatcata tgctcaaaca tcgcaaaacc ttccatttga tactcacgaa gcgggttcgt 3069601 ctgcgcgtaa gcacgaaggt gaatcccttg gcggagctga tccatcgcat caatatgatc 3069661 catccattta gaatcaacgg cacgaagaac gataactttt tcgaattcgc gcatttgctc 3069721 tttgccgaat tgctcttcct tctcattata ttttgtgatg atgcgatcca taatgagctc 3069781 aagcatttca tccggttctt tgccgaagat atcgctcttc tcaagtgcac cttcatcaag 3069841 ataagttgtg ttgataagat caactagacc gtcaagcttc cactcctcag gaagctcttc 3069901 tcttggcgta taggctgcaa ttgcgcgttc gagagaagac ttgatcatat tttcaacgat 3069961 ttcacgcagg ttttcagagt caatgacttc aaagcgctgc ttataaatga cctcacgctg 3070021 ctggcggaga acatcatcat attgcagaag ctgtttacgc gaatcgaagt tattgccttc 3070081 gacgcgtttt tgagacgatt caaccgcgcg agataccatt ttgctttgga ttggagtaga 3070141 gtcgtccatg ccgaagcggt caagcatcgc cattgtccgc tcagctccga atctgcgcat 3070201 caattcatct tccatagaaa gataaaattg agtaatcccc gggtctccct gacgtccgga 3070261 acgacctcga agctgattgt caatccggcg tgattcatgt cgttctgttc cgactacagc 3070321 gagcccgcca agctctttta caccttcgcc aagcttaatg tccgttccgc gccccgccat 3070381 gttagtcgca atcgtaactg cgcctttttg gccggcctct tcaatgatct gcgcttcacg 3070441 ttcatggttt ttggcattta acacttgatg cggaattcct ttgtttttaa gcagcttaga 3070501 aatcaattca gatgtttcaa cggcaaccgt accgactaga acaggctgtc ccgtcatgta 3070561 acgctgtgcg acatcctccg caactgcctt aaactttcct tccatcgtgc ggtaaattaa 3070621 atccgggcgg tcatcacgga caacaggcct gttggtaggg atcgtgacaa cctgcatgtt 3070681 gtagatgttg cggaattctt cttcctctgt cttagctgta cccgtcatac cggcaagttt 3070741 ttcgtacatt cggaagtagt tttggaacgt aatcgtcgcc aaggtcatgc tttcgttttg 3070801 aatctcaagc ccttcctttg cttcaatcgc ttggtgaagc ccctcactgt agcggcggcc 3070861 tttcatcaga cgtcccgtga aggaatcaac aataacaacc tgtccgtctt ccactacata 3070921 gtcaacgtcc ttttgcatcg caacgtgagc ttttaaggcc tggttgatat ggtggttgag 3070981 cgcgacatgc ttcacatcaa agaggttatc gatgccgaat gctttttccg ccttcgtcat 3071041 tccttcttca gtaagctgta cagcttttgt tttgatatcg tacgtgtaat ccttctccgc 3071101 ttttaacgtg cggacaaaag catttgcctg tacgtacagc ttagtggatt ttgcagcttg 3071161 tccagaaatg ataagcggtg ttcttgcttc atcaattaaa atagagtcaa cttcatctat 3071221 taccgcaaaa tgaagcgggc gctgaaccat ctgctcttta taaagaacca tattgtcacg 3071281 caaatagtcg aagccaagct cgttgtttgt ggagtaagta atatcagcgg cataagcttc 3071341 ccgtttttcg tcttttgaca ttgagtttaa attcaaaccg acagtcaaac cgagaaactc 3071401 gaaaattttc cccatttgct cagcgtcacg gcttgccaag tattcgttga cagtcacgac 3071461 gtgtacgcct ttaccggtta acgcatttaa ataaacaggc agggtagacg ttaatgtttt 3071521 cccttcccct gttttcattt ccgctatatt tccgtcatga agcgccacgc cccccatgag 3071581 ctggacttta aacggaaaca tgcctgttac gcggcgtgaa gcttctcgaa caacagcgaa 3071641 agcttcaaca agaagatcat ccgttgtcgc ccctttttca agacgctctt taaattcaat 3071701 tgttttatgt ttcaatgcgt cgtcagagag attttcatag tctccgcgaa tcgcatcaat 3071761 atcgttagca attttttcgt atctattcag cgtacgtttt gttggatcaa acattttatt 3071821 taaaattcca agcatttata acgctcctct atcatcacac gcctatttta gaggcatgta 3071881 taaataattt actagtccat gtatacctct cattatcata tcataccttt tgttatttcc 3071941 aaagaatttg caaataagaa aaacaaaaac cttccgcgga catcacggaa ggcttctctt 3072001 cattattcag tcggttcaat taagccatat ttcccgtcat ttctgcggta cacgacattt 3072061 gtaaggtttg tttccgcatt tgtgaaaaca aagaaattat ggccgagcat attcatttgc 3072121 aagatcgctt cttcactatc catcggcttt aaattaaagc gtttctgacg gacgatgtcc 3072181 aagctctcct cctcttctat gtcatcctga accgcaatat ctgtatcaga gccaagaccg 3072241 tttgccaata aatattttgg agagccctgc tcacggaatt tacggtttac tttcgtttta 3072301 tgcttacgga tttgacgttc cagtttgttt gttgcgagat caattgcgtt gtacatatcc 3072361 tcgttatgca cctcggaccg aagcgccaga tctgtcatcg gaatcgtaac ctcaacctta 3072421 gactccttgt cattgtaaaa cttcaagttg acgttcacat cagcatccac gctatggtca 3072481 aaatagcgct ccagcttgcc gatcttcctc tcgacatgat cctttaacgc gggtgtcact 3072541 tcaatatttt ctcctctgat gttatagttc atcaaagaac gcctcccttt tattaaggat 3072601 atgtatctat ttctctttta ccctttacaa ttcctgctga aacataaatc ttttgtgaaa 3072661 attcagtgaa ctttgtcgaa ttttgtttgt atttgctctg ttattggcgg ttcggaggta 3072721 tatgtatatg ctgattgaac gaaacaaata cctcacacac gcctaattga ttaaaaaggg 3072781 ttccatacat tgatgaatag acagcatcca ttttctataa tgaatcagaa aatgttcctt 3072841 taaatactca cagaactcat gagagggaaa agagaaagag accaattgat caaactccgc 3072901 aaaaatttgg tcaaatgctt tcacacaaat ttcagcacac cgcgaatcca taatgaagag 3072961 aagtgttgaa tgtgttgaat ccaaataaaa aaaggcttgg atcagatctt ggtagatccg 3073021 atccccttct gtttttgata aattctcttc agcctctatc aaataacaca acccctcttc 3073081 gatggtaaaa agaagatgat aataagctga taaaagcgta taatcttcaa tgctcttcaa 3073141 ggcactcacc tatttacgct tgtcataata tgtgccgtca atcgtaatgt tgttataagg 3073201 gtttaaatac gtcgtatgca tcacacgttt tcttttcatc tgctgaagtt ctgttgcgat 3073261 tgactgcttc agtctttcca tttccttcac aatcagctga tcccatgtca aaataagttt 3073321 catctgcttt cgctcttctt ctgaaagcgg cagagatatc tcctgaatca gttcagaccg 3073381 tgtagccaca aagtcttcaa tttgctttaa aagttcatcg ctttccggcg tattttgtat 3073441 gtgtgacagc atactcttcg tctcagtgta tagttgatct atattattca tgcgatcccg 3073501 cctgatccgt gccggtcctt ccgctcactt tgaatggctt gtttccaagc atcgcgaaaa 3073561 tctgttacat aaccttcaac ctcagccagc atgcccgtat catttttgat atttgcctgt 3073621 accaatctgc gatacatata atcgtacatc gcacccatag aagcggaaag ctctatgtta 3073681 cggttaagtg taaaatttaa ttcctgaata atattttgcg ctttaatcag attttcattt 3073741 ttacgttcca tatcatcatt ctcaatggcc tgagcggcaa gtcttataaa tttcaaacag 3073801 ccattataca gcataagcgt cagctccccg ggtgtagccg tattcactga attttgctga 3073861 taggctgtat atggattttg gatcgccatg tgtcatcctc caaattacat ttattgtaca 3073921 agaagctgtg ataaatagga cgcttgttcg ttcatttttt gaatcgcaga atccattgca 3073981 ctgaattttg aataatagcg gttttctatg gtattcaatc tgtcctgcat atcagttatt 3074041 tcagtactta tcgagtttaa attttttcca atggaatagc tactagctcc cattgtcgag 3074101 ttcccagctt tagcttcaat acttttcaca gtacttctaa gtgtattagt aatccgcttc 3074161 ataatacctt tatcgctata gttactatca tttgttccac ttgtaaaaag attagcaact 3074221 ccttgaggat cttctgctat ttttgctttc aatttctctt cgttaatctc taagtgccct 3074281 cgcagttggt aagcacttga agttgtgatg ccaaattcag ttaattgata ggttttccca 3074341 tccgcattca cttgagtata aaagtcagtc cgcatttggt tcgtgccagt gctgatgctt 3074401 gaatcgtttc tcagcaatcc gcttttcgcc ttctcctccc agagctctac ctctttatcg 3074461 gacatggctt ctttttgttc actcgtgagt ggcgtatagt ctcggtattt ttcttctttc 3074521 agcttttcat tcaggctgtc aaccagttca ttgtatttat ctacaaactc tttgatttgg 3074581 ttataaatcc catcaacatc agtagaaaca gatgtggtaa cagggcctgt ggctgcagtt 3074641 gtatttttaa tcgaataagt aacaccattc accgtgaaat tgtttgtcag cttctccatt 3074701 tcaaagccgt tgattgtgac tttggcattt gtgccttctt tgtaagcagt aagcttatta 3074761 tcagcatcca aagaaaaacc aagctgaccg gacataaagt cagctgtagc agagtctgct 3074821 gcctgtatgc ttcctcctgc acctgttgct ttagaagaaa acgcaatcgt ttctacgtac 3074881 tctgtaccat tccaaatttt atctttaaat gctgatactc ctagatctga gctgttaagt 3074941 ttagaaatca cattatcaat cgtatcggca ctcgtcacac taatgttcac tgtttttgct 3075001 gttgtttcgc caggcgcaac aacgttaaat gccaaattgt aatcgccttg tgtgtatccc 3075061 gtataattgt ttgccttata cgttgctgca gttgccaagc tcgccacttc aacagtagac 3075121 gaagaatttg gcgcacttac gcttcctgta gcagttaaca cagactcatt agagcttgtc 3075181 acagttttgc tctgatacgt gctcggatat gtcaacgtat ttttagacat ataatcttgc 3075241 aattctttta tttttgagtt tacttcacga tagctgtcac gctgccattc aagagtctgc 3075301 tttttttgtg tcagcttatc aagcggcgct ctttctgtct gcatcagctt tgatacgata 3075361 tcatctatat ccattcctga cgccagacct gttattcttg tgaccatctc aaaccactcc 3075421 tattctactt tttttcatct acaaataacc caagaaattc agtcatagcc gcataaaaat 3075481 caagccaccg ttttggtgga atttcgcgga tcacttcatt tgtagagtcc tctattacct 3075541 ttacatagta ttcatttaac ttgtcatgaa gctcgaactt cagatgaact tgcgaaggtt 3075601 ccaaaagctt gttcatttcc cccaccattt cagcaagatt ggtatatgaa acttgatgaa 3075661 caggaacctc gttatcatta tctttctgat tatgtatttg agtatcataa cgatcccaaa 3075721 caggttgtaa cgtagtgagc ctttcaatgt tcaattgatc atcccctatg ccccaatcta 3075781 tcgtttatat cgactaagtc gagataagat tacacatatt tttggaaaaa aatcttctgt 3075841 tttagatttc ttgtatggaa atacatttat aaaaagttag tggagaatcc ggttattata 3075901 tcatgagtta gtgacaggat gaggaatgat taggagatag aaatttaaat taaaagaccc 3075961 tggcaacgcc aaggtctttt ttaaaattaa cgtaataatt gaagtacgtt ttgcggctgt 3076021 tggtttgctt gagcaagcat agcttgagaa gcctgagaaa gaatgttgtt ctttgtgaat 3076081 tcgctcatct ctttagccat gtcaacgtca cggatacgag actcagcagc tgtcaagttt 3076141 tcaccagaag cgcttaagtt gttaattgtg tgctctagac gattttgtac cgcaccaagc 3076201 ttagcacgtt gagaagaaac ttggttgatc gcttcatcaa caactttcaa ttgagcatcg 3076261 aaaccgatat cagcagtatc tgctgcatta tctgcgaatt ttgttacgtc aagatcatta 3076321 actgaatgaa gagctgcaat tgaaccatca gcttctttaa ttccaagagc gtcagcaccc 3076381 atatcctcaa tatttacaga gatttgctgt gtagcatttg ctccgatttg gaataccaag 3076441 ttcttttgat ttgcaggagt agctgtgtca actttgtaag tgccatcgag caatttctta 3076501 ccattgaatt ctgtacgatt tgaaatacca tcgatttcat ctgttaaagc tgaaatttca 3076561 tcttgaatag attgcaaatc agttgctttg tcctgagttc cagtgtttcc agcttgaaca 3076621 actagctcac gaacacgttg aaggatcgca tgagtttcag ttaatgcacc ctcagctgtt 3076681 tggataagag agattccgtc ttgagagttt ttagaagcca tttcaagacc tctgatttgt 3076741 cctctcattt tttcagagat cgcaagacct gctgcgtcat ctcccgcacg gttgatgcga 3076801 agacctgaag aaagtttctc catgttcttt tggctcgcac tgttgtttga agacaaacgg 3076861 ttcagtgtgt taagcgctgc aatattgtgg ttaattctca ttgttttgtt cctccctgaa 3076921 tatgttgtta aggcacgtcc ttgtgccctt attttgtaac tggctgagtc ttttgcgcct 3076981 cctcccggct acatcattaa tatcggattg tctctgattt tgttaataca aaaataaaaa 3077041 aatcctcact ttttttgtga ggataatgcg gagatcacat cgctggataa cgctgctgca 3077101 cggttatttt cttcctgaat ggtcaagtaa atttctttcc tgtgaatatc aatatgcttt 3077161 ggggcgtcaa ttccaagctt cacttgatcc ccttcaaccg caatcacttt tacttcaata 3077221 tcagcaccta tttgaatcgc ttcgtttatt ttccgcgata aaactagcat gattctcctc 3077281 caatcggatg ctttgtcgta tatgaggagt cgtgtaaaac gacttgctta gccatcatgt 3077341 tcttgcgatt cacaataatg ggagccaata aattcgcagt agacttttca aatggctctg 3077401 ccatagtcaa tattgtcatg acttctacgt cttgaatatt atcgatatcc aaaagttcag 3077461 cagttgattc atcaagatca aattcataat tcttaaaaaa gataaacgga cttacgacga 3077521 taaacgcaag attttctgaa gtgacggact gcagtgccac gaatggagag tcttctgaaa 3077581 gcggaagtat gacgaactgt ttttcttcta aaaagcctgg aatcccgctt tcaaaaagaa 3077641 tgatttgttc ttcttttatg ttcatttggc catggtactt cgtatgaatg atcattgttc 3077701 acgatccttt tctttttact tttcgggtga ttctttcggg tattctacat ctatatttaa 3077761 atcagggtat tgaagcatgt caaccttaac atttcctggc gtatattcaa caattggctt 3077821 atgcggctca gcctgaataa caggctttcg cggcgtaatc tgcacatcaa gctgtgacgg 3077881 agtatattgt attttcaccc tcgaaagaga aggagcataa ttttcgccta attgaatttg 3077941 gtgcatttca gagttcctcc ttgcttgtga agcgattggg ttccccttat tttcaatctt 3078001 cataagctcg tcgccttctt ctgcagtgcg tgctattccc tccattacat cctcatgccc 3078061 ttgttgggcg gcttcttcaa ttctcttgaa aacatgcttt ctgtctaatt cttcccatgc 3078121 ttgtgtctgg tcaatcgtga gttttccagg tgtcaccgat atttccattt ccgcactcgg 3078181 ctgttcgatc tctagatcag cttgaggctg ctccattttt aagctggcag gcgtcgttgt 3078241 taaaccaatt tttccttgaa cactatgcat aatcaatctg ggaatctgca tcactctacc 3078301 tcctgaacta taaaaaaagc gaactcctaa gagccgctta ctttaaaaag tcaatcaatg 3078361 taggctgaac aatttgcgca ttaacggcca gagtagccct gtgcacactt tgctgcgcaa 3078421 taaattcagt tattacttct tccagttcta catcttcatt gtctgataac actttggtag 3078481 ctgtttcttc ttgcgctgac agtcttgtat taaccagttc aagacgatta tatctcgctc 3078541 caagatcaga tcgttcagcg ctcatgccgt cagaaaaatg atcaatatca tttaaaacac 3078601 tgtccatgcc atctagcgaa ccagaattta gtgctttctc aaaagaatca agcatttcaa 3078661 atacattctg cccgctttca gaagtgcctc caaaagctga ctttggatct gaattcactt 3078721 tcaatgacat attatttgat atattgacta cgacatcagc tgtatcagaa attgtataag 3078781 ttccgtctcc gttatctgta accggaggct tatctgaatt tgtgccatta aagatatatc 3078841 tgccgttcac ttgtgtattc gcaatattta aaagctgttc ctttaactgc tttacctcta 3078901 cgccaatcgc ttgccgctcc ggctcgccgt ttgtatcatt ttgagcttca accgctaatt 3078961 ctctgacctt tgacaagatg tcaattcctt ctgtaatgtt tgtttctgtg ttttcgagcc 3079021 aggtaaaggc ttgagaagca ttgcttttgt actgctgcac ttgagacagt tgcgtattat 3079081 actttaagct tttcattgct actacaggat cgtcggaagc ttttgagatt ttttttcctg 3079141 aagaaatctg cgactggagt ttatccagct tcgagtagct tgaaccgata tatctcagtg 3079201 agttttgctg tatcatgcct tgtgttactc tcatgtgact ctacctacct tcctccaaca 3079261 cccatgccgt tgatcacttt atcaagcaat tcgtcttgta aagtcaccat tcttgcagct 3079321 gcattgtatg cgtgttggaa ttgaatcata ttcgtcattt cttcgtctaa agaaactgcg 3079381 ctcatttgct gacggtttat gtcagcatca ttcagctgtg tttctgtatt agacgccagt 3079441 cgattagcct cttgagcttc gatccctagc tcgccaatca gacccgcata ataatctaaa 3079501 acactagttt ctttaccgtt aatggttatt ttaccggtta aaacatttgc taattttgta 3079561 gcatttgcgt tatcgttggc tgcgccagtc agtgagaaag caatgtttgc gccttttgaa 3079621 tctattatgc tgtcagccac tttgatcttg cccgccgcgc ccttggcagg ttcagtttca 3079681 ccgccagtaa aatcaaaaaa gtctccgcct tgttcaccgc tcttggtcac accatttctg 3079741 tgcacttcat tgaaagcttt cgcgaattca agcgccatat tgtcaagatc agaaagcatt 3079801 tccgggtata cgcccttttc ttggccatct gctgttatat acccataaga ctctataaac 3079861 cctaaaaggg atcccttgct gctaaaggac tccgcctgta cagctgtatc cccgattgaa 3079921 atacttgata ctaacccagt ttcattatca tagttggctg caagttctga aacctcgtaa 3079981 tttttaccgt ccaaaacagt tcctagcgac tgtttatttt tatcaaggat ttcaattgat 3080041 acagttcctt cagcagatgc aagtgcattc ccgcctgatt tgttgtagct gactttgata 3080101 tcaaccattg aggataattt atcgatcagc aaatctcgct ggtcatataa gccattcgga 3080161 agaagcccga ccggctctac ttgtgcaatt tgcttattta aactgtttaa ctgagaaagc 3080221 agagaattga catccaacac agttgtattt agctctgctt ttaaattcga ttggacattt 3080281 gtaagtgatt cagaaatata attaaacgtt tcagctacag cttgtccttt tcgagcaaca 3080341 acagaacgtg cactttcttc atttgtatta ttcgataatt cctgcaggga attccaaaac 3080401 gaattgagca cactgttcaa gccgctgtca tccgtttcat ttaaaacgcc ttccatttgg 3080461 gacagcgctt ttgccttcgt gtcatagtat ccggcactgt tgttttgaag acggtattgg 3080521 tagtcaagaa agatatctct tattctctca actgattttc cttgaacgcc cgtacccatt 3080581 tgtcccgctg ttttttctgc atttttagat acagcaggga aatagtcagt tgcctccaat 3080641 gagacccgct gtcttgtata accatcagta ttggcatttg ccacgttatt tgcagtagtg 3080701 cttaacgctg cctgctgagc gcttaacgcc cgccttgcag tttcaagccc cataaaggta 3080761 gatgtcattt tctgaattcc tttctgctaa gcttttgaat caaacagttt cattttgcta 3080821 cttttcggca gctcagcttt aattgatttg ctgtaattga agttattttc cttaggaacc 3080881 agcatatcgt acgaaataga gatgaattgc agcgcgtctc ttgtcagctg cctattcatc 3080941 tcatttactt ttttcagacg tccgagaact tgagaaagag attcgtatag ttgttccagc 3081001 tcttcctttt cactgcctga ggttttggcg atacatgcgg aaatagtatt attttcgcta 3081061 tatccgagaa aggccgaagt tgttttgatc cggtcatctt ctgtctgcgt gattgcttga 3081121 atatattttt gctcttttgt caaaatgtta gaaagctctt ttgttttgcc ggctttgagc 3081181 gcttccgtct tttcttcaga cagcgtgagc aggtgctcat gcagaacgca aagtcgcttc 3081241 aattgttcaa taattgcctt cgctgacatg ggctttctcc ttttttattg ctttttataa 3081301 aaattaatca tatttttcgc aatatgattt gcgtctactt tgtatgaccc gttttcaatt 3081361 tgcgctttaa gctgcgcaat tttttcctgt cgtgaaccag tgactgcgtc ggatgcatgt 3081421 tgcatttctt tagcctgtga tgaaatttca attttatctt gaggttgtgc aacagttttt 3081481 tgcaccgctt gcttatcata atttttttga tatggattaa cggattgtgt tccaaattga 3081541 ttgattttca taggattcct ctcgctttcc gttgcagtct ttaaacaatc ttaacccttt 3081601 tatcgactgc gttttcagtt agtttaggga atcagctgtt tttggtatta taggcatagt 3081661 atgtgtcttt tttactattt tctttctcga ttttcagagc atcctcgtgg ttcaaatgat 3081721 ccatttgatc cttaatatca gactggcaag ccttgcagaa cttgccttct ctaatcgatg 3081781 tcccgcacct ttcacaaggg tatgccaaat taggaagatg agtgatctga attcgcttct 3081841 gcctgatgaa tttcaatatc agctcttctt ccacacctgt ttcctcagtt atccggctca 3081901 aagttgattg ccggttttcc tgttttctta aaaatttata gacagtctca aatgattttt 3081961 cttcttcctt aatacacgcc tgacatacgg tttgcagctt tgtttttaaa aataaagcat 3082021 tgcatttcgg acaattagcc agttctccca tctttttttc tccttattag ataatatgcc 3082081 tgtgtcaatt tctagtgatt atatcggcat aaaaacagaa tcatttagct tctgatcaag 3082141 gtaaaagatg acactgaagc ggcttttcct ttttctaata agcagcgggc tgcgaagtgc 3082201 aaggtggcgc ctgttgtata aagatcgtct attaaaatga tattcatacc ttctgctgaa 3082261 ttattttttg tatcaaaaat gcactctgac agcaggcgtt ctgttttctt tttctttgac 3082321 tgtttctcat tattcaggcg aatgagggga tggtgggaag gccggtctaa acattctgcc 3082381 aagagatgtg cctggttaaa tccgcgctct tcttcccgtt ccttgctcag cggaataggt 3082441 acaagaacaa aatgcttatc ggggtaaacc ttagaaaagg ttgaagaaaa atcactttta 3082501 aatgcattta tgatttctgc atctcctcta aatttaaaac gggagagcgt ttctttcatc 3082561 atatcattat atgtgtaaac tgaacggttt tgacgcaata gcaaactgtc tctgatcctt 3082621 gttctccaca cctcgcaatc cctgcatacg gcatgaacag attgaggtct gccgcacagg 3082681 gggcagatat gtcctgtgat tttctttaat ttgcttctgc aagaataaca aaccttttca 3082741 tcaggcttta gtaaaaaaag ggctctccat gtaacatctt gagaaaattg cgaatcacat 3082801 aataaacaga tcagtttatg aatgcctcct cctgcttcgt ttgacataaa tcgcttggac 3082861 tctctgaaac tactgcagca gattcagcca aaatgacaag cattgctgtg tttttttgtt 3082921 tatctaccag ctcagctttc gtatatgcga tctttttaaa atcagtaacg taggatggac 3082981 tcactttgtt taaagaaagt gccaatacat cgttttggca tacttggcaa gtacaggcca 3083041 tatgaagctg gtccatatat cggtcgagca gttctttcat tacgatttct tttgaattga 3083101 caagcatttt tacagctcct catcatcggt tatatgagta tactgtacca cgttttcaaa 3083161 taatggctag tctgtacatt caacttttgc tgccaattca ttcatttctt ttatatgctt 3083221 tcttgcatcg agcatactct ttgttttgcc gaagtgaaag taaatgacat cgccgtccgc 3083281 atattcttta tgccggccgg ttcttcctgc aatttgaaca agtgcgcttt ccgtaaagat 3083341 agacgattcc gctcctagta cacccgtttg caccttgggg actgtgacgc ctctttccag 3083401 tattgttgtt gtgattaata gatcgagctg accatctctg aattgctgca ctttctcctt 3083461 tctatgcttg tcttccgcgt gcacagatgc ggttcggcaa tgaacacctt taaagcacgc 3083521 agcagccttt tccagaatag aaacggaagg aacgaataaa aaaacaggcc tcccttcttt 3083581 tacatgaaac tctatccatc ttttcaccgc tggcggaatt ttatttcggt ttaatttctt 3083641 cttccagttt ccacaccata caaagcgcgg ttcgggtaaa ggtttccggt ggtgtcttgc 3083701 ggggatgcga actgaatgta actgtccgtt cagtgctttt ctttttaatt ctttaggagg 3083761 tgttgcactt aaataaacga gggtgctgtt tttctttctt gctttttgaa cagcgaattg 3083821 aagggtttga tcagcagaat atggaaaagc gtcaacttca tcaatgatca taacatcgat 3083881 tgcatcttta tatcgcaaaa gctgatgcgt agtggaaatc ataagcggag atagccgccc 3083941 tttgtcatcg cttcctccgt aaagcgctga aatgtcagca ccctgaaagg cagccttgag 3084001 tcttggagca agctctaata caacatcggt gcgaggtgtt gcaatacata cacgcagtcc 3084061 ttgatttaac gctgattcta taccaggaaa cagcatttct gttttgccag cgccgcaaac 3084121 cgcccagatg aggagctctt ctttttttga tattgcttca attaaaacat tggcggcttt 3084181 ttgctgtccg cttgaaagct tgccatccca tgtcagctta atagacttcc agtttgattc 3084241 attttcctct ttccatgaat ataaaggaac ctcctcactc actctgccca tcatgacaca 3084301 ggaacggcaa tacagcttat tctttccaga tgagtgataa aaagaaaaat accgctgatc 3084361 agtttgtccg cacctattac atctatatct ccgtttattt atggatatag aattttcagc 3084421 agtgatatat ccattcttga tatgccattc aatcatctca tcggaaaatg agagctcagt 3084481 cctgagcaaa tgacggcttc gaagcgtctg ctgcaattct tttgaaaagg aactgttttt 3084541 ttcaactggc acattcacat agcacgcctc ctttcgaaac agtatgcctg aatgaatatt 3084601 ttctgtccaa ctattaaaat aagaatataa aaaaatctcc gctctaaaaa cggagatttg 3084661 gccttattta aaacaccagc aaattcctaa cgcaccttca cccaaatgag tgccgattac 3084721 cgcgccaaaa tagctgttat aaaattcaac atgaggatat tttgcagaaa gctcttcaat 3084781 gattttcgct gcttcttcct ctcgattagc gtggataaca gcagctcgca taggcaaccc 3084841 tttactcgca tcttcgtcta aaagctcata aattcgcgaa attgcttttt tacgtgtgcg 3084901 aatcttctca aaaggcacaa ttaccttatt gtcaaaatga aggataggct ttacctttag 3084961 aagactacca atgaaggctt gggcgctgct taatcgcccg ccgcgctgaa gatgggctaa 3085021 gtcatctacc ataaaataag ctcgaactgt ttttttcatt tcttccagtt cttttataat 3085081 atcttccggc gatgatgctc cgtttttgat taattcagca gctttaaggg cataaaagcc 3085141 ttgagccaag cagctgatct ctgagtcaaa tggatacaca tcaatattgt cgaccatcga 3085201 atcagccgct gctgcactgc tgaatgttcc gctgatcccg ctggaaagat ggatactgat 3085261 aaccgcatca taagacttgc caagctcttc atacaacgca accagctcgc cgattggcgg 3085321 ctgagaagtc gtcgggagct cattatgttt tttcacttct tcataaaagc ttttccagtc 3085381 caactcaatt tcttcacggt aagtctcctc cctaaaaaca acctggagag ggatcatatg 3085441 tatctgatgt tgttcacgca tttctttcgg aatatatgcc gtgctgtctg ttacgactgc 3085501 aatattcata gcttcgatac ctgccttatt gctttataac tctattgtaa gggaaacggc 3085561 agcctaaaaa aagacctgcc tagtaaaagg caagtctcct attatactat ctcatttcta 3085621 cccagccatt tttaatggcg accacaacgg cttgcgtccg gtcgtttaca ttcatttttt 3085681 gtaaaatatt gctgacatgg tttttaacgg ttttctcact gataaacaat gattcaccaa 3085741 taccgcggtt gctttttccg tctgcaagca tctgcagcac ttcacattcc cgcctagtta 3085801 aaatatgtaa tggtctgcgg atttcagggt aaacctcatg ttgagggtgt gcagaaactc 3085861 cgcttgttgc aaggcggcgg aattcgttaa cgaggttgtg agtaaccttc ggatggaggt 3085921 aagatccgcc ctcagccact actttaaccg cttcaattaa tgtatcagca tccatctctt 3085981 tcagcagata acctcttgca cctgttttca gggcatgtgt tacataattt tcgtcatcgt 3086041 gaattgatag aataattact ttagattcag gatacagctc tacaagctgt tttgtagctt 3086101 ccacaccatt tacgtttggc atattgatat ccatgatcac aacatcagga tgatagtgct 3086161 caacaatacg agccgcttcg tccccgtcat caccttcggc taccacttca aaggtaggtt 3086221 caaaatccaa tatccgttta acaccttcac gaaataactg atggtcgtcg ataataacaa 3086281 tgtttacttt agtcacaagc cacgcctcct tgtattattg ttctatatac tctagcattc 3086341 ggtcaatatg ccttttggct ctattttaca aatcatagtc aaagagataa cggaacctta 3086401 atcataataa atgtcccaag acctattttc gaatctattg tcatcgttcc ttccaataaa 3086461 tctactcttt ctttcatgcc cagcaagccg aatgatttgt ttttcttctc tttcgcttcc 3086521 ttcaggtcga accctttacc gttatctttt atcattaaaa tcacaaaatc ctttgtgatc 3086581 tcaactttga ctgtaatttc ttcagattca gaatgcttta gcgcattaga cacagcttcc 3086641 tgtgcgagcc tgaagagcgc aacctcaaac tgaggcgcta gcctctgatc ctctgtttct 3086701 ccaatgcact gaaaatgtat tttgaccttc ccgttatatt cctcggttgt atatagatat 3086761 tttcttaaag ttggaatcag gcctaggtca tcaagggcca tcggtcttaa atcatatata 3086821 atccttctca cttcgtaaag ggcattccga acattttggc ggagattttt aatttcttgg 3086881 aatccgtcct ctgcgccccg gtcacggaaa atccgctcga ttaattccga tctcatcata 3086941 acattcgcca gcatttgagc gggtccgtca tggatttctc ttgagactct ttttcgctct 3087001 tcttcctgcg cctcaataat tcttaagccg aaatcctgtt ttgcctgagc atcagcaaga 3087061 agcagtccaa cttcgcgcaa atcctgattc aagtagttga gcacaactgt aatttggctt 3087121 actaatgatt ctgaccgctc aatgatttcc tgaagcccta gcaatctgcg ctccaaatcg 3087181 tcccgccgtt cgcgcaattg cttctcacgc tgctggatca tcgtcaattc tacctgcagc 3087241 ttatgggctt tttcataagc attgcggatt tcctcttcac tgaatctatg aaaattacgg 3087301 ctgacctcgg ataaacggtt tctcgcatgg cgagtttgca cttcaagttt atcgccaagc 3087361 tcaatcactt catacacctg ctgtttaatt tgtttcagtt cttcgaccag ctgttcatac 3087421 tgctggcgtg actgctcccc gatttgaaaa acctcgtcct tgctcccgtc aacggttttc 3087481 agcatcttca tcaaaataga atccagcact ttggaatcca tctttgtttt attcataatt 3087541 tccctccgtc acggcgttgt catatatttt tattataaat gtaattgatc tgcaaattat 3087601 gtcgaattat aatgaaagaa tgcgtatatt ctagaaaaaa acatttttat atactatcta 3087661 ctctttatga taccaaaata cgcacaaaaa ttctaaagac tgtacgaatt tgtataggca 3087721 gtcttttatg cttagcagga gggtcagcta gcatgctgca cagctatttt actgtgaaag 3087781 aagcgggaga acacgagatt gttatagaaa aatcgcgttt tatctgtcat ttaagccgtg 3087841 tttctaccga acaagaggca caggaattta tacagaaaat aaagaaacag cactggaatg 3087901 cgactcataa ttgctcggct tatgttattg gcgagaatga tcatatccaa aaagccaatg 3087961 atgacgggga accaagcggt acagcgggag tgccgatgct cgaggtttta aaaaaacgca 3088021 ggctgaagga tacttgcgcc gtcgttacac gctacttcgg aggcattaag cttggtgctg 3088081 gcggattaat tcgcgcttat gggaaatcag tgtctgaagg attaaatcat ataggtgttg 3088141 tagaacggaa gcttatgcga atcatgcata cttctgcaga ttacacatgg cttggcaaga 3088201 ttgaaaatga attaagggag tcacaatttc tgttaaagga aatccattat tcagaaaatg 3088261 ttgaattcga aacatacgtg gaagaaaaag aaaccaacgc tttttctgaa tggatgacag 3088321 aactgacaaa tggaaagagt gatattaaag agggagagtt gacgtatctt gaaaaagccg 3088381 tcaatcacat aaaggagact gaataatggc tgaacgcgtt agagtgcgtg tgcgaaaaaa 3088441 gaaaaagagc aaacgtagga aaattttaaa aagaataatg ttattgttcg cccttgcact 3088501 attggtagtt gtagggcttg gcgggtataa actttataaa accattaacg ctgcggatga 3088561 atcgtacgat gccctatccc gcgggaataa atcaaatctt cgcaacgaag ttgtagacat 3088621 gaagaaaaaa ccattttcta ttttatttat gggaatagag gattacgcga ctaaaggaca 3088681 aaaagggaga tcagactctc ttattgttgt taccctggat cccaaaaata aaaccatgaa 3088741 aatgctgagc attccgcgtg acacacgtgt gcaattagct ggtgacacaa cgggaagcaa 3088801 gacgaagatc aatgccgctt acagcaaagg cggtaaagat gaaacagttg aaactgttga 3088861 aaacttcttg caaatcccga tcgataaata tgtcacagtt gattttgacg gatttaaaga 3088921 tgtgattaat gaagtcggcg gtattgatgt tgacgtgcct ttcgatttcg atgaaaaaag 3088981 tgatgtagac gaaagcaaac ggatttactt caaaaaaggc gagatgcatt tgaacggcga 3089041 agaagcctta gcatatgccc ggatgagaaa acaggataaa cgcggagact ttggccgtaa 3089101 tgacagacaa aaacaaatct taaacgcgct gattgaccgc atgtcaagtg caagcaacat 3089161 tgctaaaatt gataaaatcg cagaaaaagc cagcgaaaac gttgaaacca atattcgcat 3089221 tactgaaggt ttagcgcttc agcagattta cagcggcttt accagcaaaa aaatcgacac 3089281 attgagcatt acaggttctg atttgtattt agggcctaac aacacatatt actttgaacc 3089341 tgatgctaca aatctcgaga aagtcagaaa aacgcttcaa gagcatttag attatactcc 3089401 tgatacaagc actggcactt ccggtaccga agacgggact gacagctcaa gcagttctgg 3089461 cagcactggc agcactggca caacaactga cgggacgacg aacggaagca gctattcgaa 3089521 tgacagcagc acaagctcaa acaacagtac aacgaattca acaactgatt catcctatta 3089581 aaaaatgccc ggtcctttta gaggatcggg catttttgcg cagaaaaaaa ctccggcaca 3089641 taagccggag tttttaattc cttttcacca gccgtttata aaactttgta aacggcttaa 3089701 atttttcatt cacgagtcct gtcacttctg ctatgatttg cataaaaata atcaaaatga 3089761 agataataaa caaagaaagc caaattgtgg cacttttaag tacaatcgca ctgatactga 3089821 aaataaatcc aattaaataa ataactaaga ccgacatccg atgtgaaagg ccaaaggcca 3089881 tcagtctatg gtgaatatgc gacttatcag gcgctgaaat cggctgtttg tttaatattc 3089941 ttctgatgat agcaaatgtt gtatcaaaaa tcggtacgcc taatataata atcgggataa 3090001 cgatactgaa caatgtgaca cttttataca ggcctaataa tgaaagaatc gagatactat 3090061 accctaaaaa cagtgatccc gtatctccca taaagatttt tgccggatgg aagttgtaaa 3090121 acaaaaaccc cagcgtgctg gcaataacga ctaatgagag tgacagaatg agcacttttc 3090181 cgccggatag cgccatgaca gcaatcgttg acaggccgat aacagaaaga ccggcagcaa 3090241 ggccatccaa tccatcaatc aggttaattg cgttcgtgat gccgacaatc cataataccg 3090301 tcagcggata agccatccat cctaactcaa atcgttctgt taaaaaaggt actgagaaaa 3090361 agtccatttt taagccagtg cttacaatca taatggctac acctaattga atcaaaaact 3090421 taacttttgc acttaattga tatttatcgt caagaatacc taacacaata atgatgaatg 3090481 ctccgactgt aattgccgtc atccttgttt ctgtgtaaat accggatgca agcacgcctg 3090541 caaccacccc gataaatatg gccagcccgc ccatgcgggg catgattttg tcatgtactt 3090601 ttcgattgct gggctggtca actgcaccta ttttaatcgc aatccttttt acgattgggg 3090661 ttatgattaa aactgtcagc agcgagacaa taaacgcaac aacaatgcga atcatgcgtt 3090721 cgtcaagcat aaagaagtct cctttggaat taaatgaagt ctttatttat atagagaacc 3090781 gttccttcca ttataccttc tccttagtta ttataacaag cttcatcaaa aagaaacacg 3090841 tataatcaaa aaacgcgcat cccaatttat aggactacgc atgtttttga atccctgtat 3090901 atttcataat ttgtctaaat aagcaattcc aatcttgtgt ccgggcgatg tttcggcgca 3090961 tttctttata ggtctcgtct ccgttttgac cgagaacttt ttcacaagcg gctataaaat 3091021 caatcggatg atcgccctct acatattcgt atacatacgg cttttgcatt tttgaggttg 3091081 acggaagatt agtgcctaca acaggttttc ctgccgctaa aaattcaaat agtttcagcg 3091141 gaaacacagc ttgattatac ggtgattgtt tatatggcat aatgccaatg tcgataagct 3091201 ccatataatg aggcacttct tttggatctg ccggaccggt ccatatgaca ttgggaagcc 3091261 tcagcagctc ttgaaacgaa acatcaccat tggtggcatc cgggccaacc cataaaaatg 3091321 tccaatcagg cttttgcagt gccgcttctt taatcatttt aaaatcgagc ttcggtttaa 3091381 tcccgccaat aaaacctaac actattcctt ctctcccctg cagtatactg cgatcgggag 3091441 cttgtttatt tgcagaaaac agctcatact ccacaccgtt ttccacagta tgaacctttt 3091501 ctcgtcctgc agtcagtttt ttgtctactt ccttgtgaag ataatctgat gaacaggtta 3091561 ttgaatctgc tcgttgtata attctcagct ctgccgattt aatgactttt cgccggaatt 3091621 cagacagcag atttgatcgg ccgctgatcg gcgcagccca taggtcactg cagtcataaa 3091681 tgacctgatc ccaagaatac agcgaagaca gcagcgggaa tccgggaaac gtgtaccata 3091741 aacagcagcg ttcaccgttt gcagaagcag gtgtaagctc atcgagtaat ggggagagct 3091801 tatgtctgta aaagacatct gtatatcgtc cgaaacgaaa catttttttc tgcagcaggt 3091861 ctttgacagc gaattgcctg atgccagaat ggacttcctg aaactctttc ccttgggcac 3091921 gcggagccgg acatacccaa ataacttcct tcgtttcctc ctgagcagct aaaaattctg 3091981 ccagccggtg ccttctgtat ctcaattggt cttttcccca ttcagcagtg gcaacgatga 3092041 catgaatgat tgcttctttt gtttccacct tcatcacctt ttctctctgt ttgcagctat 3092101 aatctttttt tcaccgcgtt ttttgcatat tgaacaaaac accatgttgc tttcataaaa 3092161 tgaagccgtt cgatctccct gtagacaaac cacgtttttt tcgcagcctt ccatttgttg 3092221 ctggaaattg aattattgac aagccgatat tcagccaggc attcattcat tccataggca 3092281 gtaaatcctt tttttaaaag agacagccat gtggctaagt cctgtctcgt tctgatattc 3092341 ggcatttgga tctgtcccgt ttgctccctg tcaatcatca ccgtcaagca gccgataatt 3092401 gtatttttca gggcgtcatc gtacgtcagg ctttccggcg catgaataaa tttatcgagc 3092461 ggggtcccgt cctgcgccat taagctgtag cccgtgaaag agaacgcaca ggagcgctcc 3092521 atcataaact caagctgctt ttccagtttg tcttttttcc atttgtcatc actgtccaaa 3092581 aatgctacgt agcgcccttg agcgcgttcc aacgctttgt tgcgagcaac cgcagctccg 3092641 gagttctctt ccagatacac cacatgaatt ctttcgtcta ttttttcata ctgctgtaaa 3092701 atgtcgcggg tcccatccgt tgagcaatca tccacgataa tcatttccca atgaggatgg 3092761 ctctgatcta ataccgaatg aaccgtgtct tcaatatagt cacgcgcatt ataggaaggt 3092821 gtaatgacag atacgagagg tttccaattg gtcatgatca catctccatc gtatgatttt 3092881 aaaaggattc tctgaaaaat tcaggaatga caacgaacat aaaggcaatc gtaaggccaa 3092941 tcataacgcc gagaactgct ttctttttcg gagacatacc gccgcctgct gtctcactta 3093001 cggtttcgga atcagtaaca cttgccgctt tcaggttaag ctgtgtgttt ttgagttcat 3093061 ataaaaatct ctctttatcc actttggaat cctcgctcac cgactcgcct tcaagcgcgt 3093121 ctatgctgct gcggatgacg gcttctcttt ctgcatacag cttttgatcg tttttgagga 3093181 aggtggagga tatggcgttt aagacagatt ccgttctatc cttatcctcg tcactatagc 3093241 ttaaagtcag taacgatttg gattccgtat tgattgtaag cttctctttg atctctgcta 3093301 catcttcatc cttttcatca ggaagcgcct ccttcaaaaa ggagtcgctc tttaatagaa 3093361 gcggaatctc ttctgtgctg ttataaaccg gatgatcata gctccccaca gccaaagtat 3093421 cttcagctgt atagctcttt tgatcagcga tctgtgacgg caggatatac cccgccgcac 3093481 ctaatataat tggcaccgct atgatccaaa tgatattttt ttttatgcga cgggctattc 3093541 ttatcaatat atcgttcata taagtctccc tgctttttgt agtctgttta tctgtacatc 3093601 ggctcaggca tttgtctgga tcgccttaac acattcacgg cggcgatgac gagcgccata 3093661 aacacccaat ggaaaaataa atttgaaaca gagcttgggc tgatacttga taccaggaaa 3093721 ctgaccatag cggtaataag tccttctgtg atcagttttg actgattttc taattttctt 3093781 tcataaaact tgtaaagcac ccatatgagg taggcataaa cggacaaata tcccagcatg 3093841 atgaacaaac caaaattagc aagaatttca acaagccagt tatgcacctc tgccacattg 3093901 tcagtatcat atacagcata atgctcaaga taataggata catttcctgc cccgactccg 3093961 aatccgtatg aatcaaggaa aaaatgccaa gcgtttttca gcagatttgc ccgagccaca 3094021 tttgatggaa gcctgtcatg aaatgaatgc agcgtctgcg gggccagaaa cagctcccaa 3094081 aactttgaat agattttgct ggcgaaaaga actgcgaaaa gagcaattcc cgccgccgac 3094141 agccatatag ccattctctt taaaacaggc ggcaatacaa tgaagatgta gacagcaata 3094201 cctgcaaaaa tgcccagaag gctggctctt gaaccagtgg caaaaattaa atacaacgca 3094261 cagagcgaga gcacaaggcc aattgccttg atgtatccat tcttaatgtt tttcatcatc 3094321 gtgatgtaaa aaaagaagct gatggataaa aaggtcgcaa agtcattttg attaaaaaag 3094381 accgatgtcg gataatgctg cttgtactcc ggtccgctgt acaatgtgga actcgcaaga 3094441 tgatggtggg tgatatgatt gtaaaaacca atgatcatca gaaataccgt catcaccagc 3094501 caaatggcat aaacaatcat cagccgctcc attttttgca cgtacatgac aataagataa 3094561 atgaagaaga tccccattgc caataaggct aaatacttga ggccaactgt taccgacttg 3094621 gcccacagca gagaaacaag gccatatata aaccaaaagg cgaaaaagag taaaatccct 3094681 tttacttgca gcccatgcca tctttcaata tgggttcgat tccgaaccat gccgaaaata 3094741 tgaaggcaac ccgctgcaat gagcagaagc cggtaaagga acaaactgaa aaatccaaga 3094801 tgaatggcaa aaaatgcatt atttaaaaaa gtgcaggcga tcaaaatata gattacagcc 3094861 ataaagagcc gttcttttgt tgtaaatgcg gttgcaagcg tcagtaaaaa caggccaatt 3094921 gccaacaccg caagcacagc agccatctgc atgaaaccta tatctttatg gatggctccc 3094981 agcaatagga cgactccaaa tatagcagcg gccagtaacg ctagcgtatg gaccgctgat 3095041 cgtttgatac tcacatgttt aacccctttc ctgatgtttc aggagccggc ggccgagcct 3095101 agcagccggc agcttcaacc aagtaacact ttttcttttt ataaattgac gcttcccaag 3095161 tctttagcca attcttcaag cggcaagccc ggaaaatact tgtcagaggg ttccgttccc 3095221 cgaacagcgg gacggccgat agagtgataa atgtatccgg ctgcctgcat ctcttcaagt 3095281 gaaaataaat ttctgccgtc aatgatgact ggctgtttta agagggtttt cacttttaca 3095341 agctccattt ctttcacttc cggccaatcc gttaaaatca ggcatgcatc agtgtcttcc 3095401 atcgcagcat acacatctgt gtaatactcg acctgttcgc caaggatcgc tgaagcttca 3095461 ggaatagcaa tcggatcgta tgcttttaca tgggcgccca gctgctgcag cattgggata 3095521 atatcaagcg ctggagcgga tctcacatcg ttcgtattcg gtttgaaggc taatcccagg 3095581 actgaaatgg ttctcccttt gacgcttccc ataacagtca aaagtttatc tacaatatga 3095641 acacgctgct tttcgttcgt ttcaatgaca gcttcgatga gcttgaatgg atagcctgcc 3095701 gattttgcga tttgaagcag cgcggttgta tcctttggaa aacatgaacc gccgaatcca 3095761 ataccagctt taaggaactt tctgccgata cggctgtcaa gaccaacacc atcagcaact 3095821 tttgaaacgt ctgcgccgac tcgctcacaa atgtttgcga tatcgttgat aaaggaaatc 3095881 tttgtcgcca gaaatgcatt cgcggcgtat ttaatcattt ctgcactttc taggtttgtt 3095941 ttaatgacag gagcatggaa tggctgatga agttcctcaa tgatggcagc ggctttatga 3096001 cttgttgaac caatcacggc acgctccata ttcatcgtgt catgaatcgc tgacccttcc 3096061 cgaaggaatt cagggttaga tacaacatca aatgagtatc tcccctttga ggctttttga 3096121 acgatagatt gcaccagttt ccctgttcca accgggactg tgcttttatt tacgatcact 3096181 ttgtagccgt taagatgctc accgattgtt ttcgccgccg ctttgacgta cgttaaatca 3096241 gcttcacctg ttttggacat aggcgttccg actgcaatat aaataatatc tgaggcccga 3096301 atggcagacg ggatatcgtt cgtaaaggtc aggcgctgat ccagcacatt tttttcaact 3096361 aagtctgcaa gccctggttc atagattggg attaccccat ttttcaggct tctgattttt 3096421 gattcatcga tatcacagca aacaacttta ttgccgatct ccgcaaagca agtgcctgat 3096481 acgagtccta cataacctgt tccaatgaca gctatttttt tcacagcgct caaccctctc 3096541 ctgtaaaatg atcttccaat ttataatggt cgcagtgtct tacgattaaa cggacgtttt 3096601 cgtgaccgtc tgatactgat gatgcaaggc cttggcgttt tttcctgcgt caaattgagc 3096661 ctgcacggtt tcatacaagt catctgctac ttccggcttc catatttgct catgttcgta 3096721 ccgagtgatc gcttccgcca aggcttgagc ggatttcggt ttaatcagca gatgttggtg 3096781 ctttccgaat aaagacgaca ctccgccaac atccgtacaa ataacaggaa cccttagcgc 3096841 cagcgcctca atcacaacag tcggcatccc ctcactgtaa gaaggaagta cgaatagatc 3096901 tgccgcaagt aaatagtctc ttacctgatg attcgggact tggcctgtga cgatatgccc 3096961 cttctgcgtc agcgtcgatt ttgcgggacc atccccgaca aagactgcct taggagagtc 3097021 ctgcagcgat tcgatcgctt cagacagttc aaaaatgcct ttctctctga ccagccggcc 3097081 gacatagaca gccagacgct gatcgagcgg gagtccgagt ctttttctga tttcctcttt 3097141 cgtctcctca ttcccctgaa aacggctgag ctgtatgccg attggcaaaa ccgagctgtc 3097201 aaagcccgaa agctttttgg cttcttcctg aagcttgtgg ctgactgcta aaacaactga 3097261 cgcagaacct acggcacgct tgaaggcttt aaacgcacct ttgctgtaat gcggatagac 3097321 attcacatca ctgccatgca aggtcaggac ataaggaatt tgcgctgact ctgacacgac 3097381 tgccgcagcc ccgcccgatg gcatggcaaa atgcgcatgg atcagatccg gatataggtc 3097441 gcgctgtttc attgttttta aaacggctga tgcgattctc cgatgaggct gcgcccactt 3097501 cagctggccg ggaactgccc gatagaaagg ccggtaaacc ggtatcccct ttctaatctc 3097561 atactccggt ctgacatcct tttttcgata tgtctttttc agcatgcgga caggtgctga 3097621 atgaaaaggc cgtgggcata tcacagtgat atcaagcccg agtttttgca gctcttgcac 3097681 ctgtgtctca tgaaacacac cctctccggg tttcatactg ctcggatata cgcttgtgat 3097741 ccacaaaatc ttcatgacaa acgtcctttt cttagtagtt tgcttttcgt ttgagggtac 3097801 gcttttacca aaagaaagag atagcacagc gccccagccg caactgaaat ggccagccgc 3097861 atttctgcct gcatactgaa gtgttcggta ctgaggctta caccaaacgc gatgatgccc 3097921 atcgccgcag taatcagaaa tggcttcata atcgactgga aataagctga aaggttaagc 3097981 ttgatgacat atgccaaaag ccagcgccca atcaggaaat taacaacgct gataatggca 3098041 tacacccatg cgactgtcag caggcttccc gtctgtacag ctgcaaacag tgataatccg 3098101 tacagcagca gcacgccgga atcccaataa aacgctaagt cagctcttcc tttagccagc 3098161 aacacagatc catttggatt catgagcact cttagtattc cgacaatcgc aagaacattt 3098221 aggatcggaa cagcagcaag ccatttttct ccgaaaaccg ctgtgataaa ggcgtctgac 3098281 acagacacga gcccgattaa cagcggaaac gaaacaagcg ccagcatttt tgtcatattc 3098341 agaaagcctt ctctgatcac gctgttttca tatttgtttt ttgcgaaaat agggaatgcc 3098401 acccgtgtga caatcggatt gatcttcaaa accggaatgg tgacaatctg ataagcgagg 3098461 ttataaatcc ccaatgcttc agcaccaata aaccggccga tcaaaatcat gtcgatattt 3098521 gctcccagcc tgttcacaag acgggatgaa agctgaaagg ctccaaaaga aaagaaatcc 3098581 ttcatgcctc tcaaatcaaa aacaaaagca ggatgccact tttttcggta tacagcccaa 3098641 tataaaatcc ctttactgga ctgcagcagg acttgagaaa tcacgtacgc caaaatcgca 3098701 tccatcataa aaaccgctat cgctaaatat ccgaatgaca atacatttga aaaaatctct 3098761 attttgctta acgtattaaa atgcagctgc ttttgcagca tatactgata ttgctgtcca 3098821 attggcgcga tcaaaaacat aatcgccaga atccgaacca gaaacaccag ctcttctctt 3098881 tgataaaatc ccgcaatgac aggactgctc acatataaaa gaacaaacag caaaacgccc 3098941 gtcataatgt taagccaata caatgttgac agctggcgct ccgtcgcgtc gtctctctga 3099001 attaatgctg cgccaaaacc catatcgagc acaatctggg cgaaaactgt aaccgttgtg 3099061 atcatgccga caagcccaaa ttctgttaag gtcatcatat ttccaagcag ggcaaactga 3099121 acaatttgta tgattgtaat acacatggtt gaaatacttg tccactttgc accgctcatg 3099181 atttgttttg taatacttgg catcatattc cctacttctt tttaagctca gattgatggt 3099241 gaataatgga atcccgtttt atcttgcacc atcacccgtc caaactactt tacaagtttt 3099301 taacataatt tttaattcta aagtgaaagt cagattgcga atgtaatata aatcaaatat 3099361 cagcttttcc ttcggcgtca tatcgtaacc gccgttcacc tgagcccaga cgctgtgtaa 3099421 agcctggaat ctcattctgg aatttttccg taaatacggg ccgttccgga cgagggccaa 3099481 tcatactcat atcgcctttc agcacattaa acagctgagg aagctcgtca attctcgttc 3099541 ttctgataaa agctccgatc cttgtcaccc gcggatcttg cttctgtgcc caaaccgccc 3099601 cagacttctc ggcatctatt ttcatggaac gaagcttata aagcttaaat ggcttcccgc 3099661 ctttccctac gcgttcctgc gtataaatgg caggccccgg cgtctccaaa caaatcaaaa 3099721 ttgaaaatac cgcaatcatt ggcagcgcaa tcgccaatcc aatgagcgca aaccaaatat 3099781 ccattacgcg ctttattgcc aaataacgag ccgtcttttc agataatgta aaagaatgta 3099841 tttgttgaac tgagaattca cgactcacat tcatgctttt ctctgcactc actgacacac 3099901 acctcacgat ttgtttggga tgttatgatg acctatgcca gtcagtttag cagacggatg 3099961 ttaattggat gtaaatggta tgttaagaag tgtgaattac gtgttttttc tgataaatgt 3100021 tgttaatact cttttactat tttatataca agtcctattt gttttaatca tttcatataa 3100081 aaaagagaca aatctgtgat tagatttgtc tctttcgatt atctgtaata agatactgtg 3100141 ccgtcatgaa tagcttgtgc agctttatct ttataaaccg cttgcttcaa tttacttgca 3100201 tctgatgcat tagtgataaa ggcagtttca actaaaacac tcggcatttt agaatattta 3100261 ataacataga aagcagctgt ttttactccc cggtctctcg ttccaagatt agccgctaac 3100321 tttggttgaa tttgttcagc cagtctcttg ctatttgcag cttgatatgt tgtatcgtag 3100381 tacgtctcac ttccatttgg tgatgagcta tcattagcat ttgcatgtat actgagaaat 3100441 aaatctgctt gtgcagaagc tgctttattt actctctcct gtaaagaata aaaagtatca 3100501 ttagatcttg acagtactgg aagagcacct gaagcattta gctttgtatt gactcttttc 3100561 gctatatcaa ggttgacttc tttctcaagg agtccattgc cgattgctcc tgaatcttga 3100621 tcaccgtgac ccggatcaat aaagattgtt tcacctacaa ctggattctt tagctgatta 3100681 gcaacctttg tgcttacggc aggagtgttt ccgataatca taaagtttga catgttttta 3100741 cttccaataa ttttacgggc tcctgtagat aaattttcac catttgtaag aataagagat 3100801 tgcttcttct tagctgccag tgtagctcct gcaatagagt cagggtagct gaatccattg 3100861 cttacatata cggtgcttgt tgataaatta agtttttgta cgatatttgc agcaagctca 3100921 tatctgtttg aaccgctaat tcttgtagga gaaggtaact tgttgtatac cgtattgctg 3100981 atacttccag tgcctcctac aacaacggta ctcgaaattc ccttatcttt tatcacagac 3101041 gtagtcgcac tatttataga tgttttattt gtaaaaagaa ttggataccc gtttttcgct 3101101 gcataaggga tgacggccgg agcgtctgca tataagaagc cgttcaaaat aacagctttt 3101161 gaagtcgcac ccatcgcttt tgccacccgt gcagccgtat cataacggtt gcttcctgca 3101221 attcgtttaa tacttatccc caagctttta atctggttag cagtgttaga agaaacagca 3101281 ggtgttccgc ctacaataat tacattttta gtctgcatct ctttcaatct tgttttcgtt 3101341 tcatatgaaa gcttatcaga attagtgtaa agcaatggcg cattcttctg gtaagcaaga 3101401 ggtgctgctg aaatagcatc tgcataggaa ctcccaccaa caattacagc tgtacttgct 3101461 gttgaataca tttgctttga tatttgtaca gcagtgccgt atctattgct tcccccaact 3101521 cttttcactg agttatcggc caaagctgtt ggcacaaaaa gtatgagccc cagaaaacac 3101581 attgttagga cttttatata agaacgcaat tgatttcctc cttaaatggc gttatatcct 3101641 aaaataatca ataacttgtc agagttgtac ctggatagta aaatttcaaa attgaactat 3101701 atgaatctcc agcttctgct cttgcttttg ctccatattg actcattccg atcccgtgac 3101761 catatccttt accgctgatt gtgtactttg aagtatcttt ttttacagtc acataagtac 3101821 ttttaaatac agtcgctcca atcattgttc ttaactcact tgttggtaca ctaatggttg 3101881 taattttgct caagttatag gagccagtac tgcttttaac aaaatacttc actttcatcg 3101941 atgctgtttt tgcacgctgc ccttgtgtcg ttccactaaa gcttaaatcg tcaatacttg 3102001 caattttgac agaatcagcg cttgtttctt tatttttcaa gatccagttc ttaactccgg 3102061 aaagtcttgc agaatcagtt tcagtcgctg aagaccacca agaagaaggc ttcgttaagt 3102121 ccaaagattt cgtatctagc tgttgttttg acaaagtaag cgtccagcct atttgaggat 3102181 cctttgtatc tttttttgca atcaagtaag gtacacttga cgaccacact tcattactag 3102241 cttctgtgta accaccatta ctggaagaat aagctgcagt tataagagat ccattatatt 3102301 tcagaacttt ccccttcgtt tgctctaccg ctttattggt attcgaattc caactgtagc 3102361 caccataaac ttgaaaagcg gttgtatcag gtacagtagt tcctgttttt gttattgagt 3102421 aggttcttgc agcgacagtc tgtgctttaa gagcctcaag tgaccagcta gcaggcattt 3102481 cattcggaat tactcctttt aagtaatcct caaatggaat attctcattt accggtcgga 3102541 tatatttagt agactcaata gagaaattaa ccgtgccaag atactgcttt ccatcaagac 3102601 taattctgtt tgaagtagaa tagttttctg gtttaattct tagggagttt ccgtaagttt 3102661 tgatgttttc aaggtttaat tttccgctgt tgatttttag attataggtg ccaccgtcag 3102721 ctaaataaaa ttcatcagca agtgaattct caacttcagc agaaattgaa ctggtacttc 3102781 caataaagtc gtatgcatat gtggctttat ctttcgttat acttttagcc gcagccggaa 3102841 cgctatcttg tttaacaaat aaaatttggc tgtttttctt cgaggcaagc gaagcgccta 3102901 tcaatacgtc tgcatatttt gtcccgttcg tcattacgac tttatcagcc ttcaacttta 3102961 gttgcttaat tatatttgcc gtaagttcat atctggttga tccaggaatc ctttgcacag 3103021 ttgaagtttt tttaatttgg ttttctacac tatcactgac gctaaatgaa ctgcctataa 3103081 tgatgacttg ttttggcaaa tcataatccg gaagcttgtc tttctctgta agcaaaatag 3103141 ggtatccgtg tgctgctgca tatggagcaa tggctaaagc gtcttgaaat actcttccgg 3103201 ttacaacgat cgctttatca tagctgccca tttgctttgc aatattttct gataagacat 3103261 atctattttt tccgcttatc cttttcacag cgccatatga tttcagcttg ttttctacgt 3103321 cttttgaaat gcttcgcgct cccccaatga ttaaaatatt atcagggtta aacttagcaa 3103381 tttgtctttc agtagttttt gttaacgtgt caggctgagt aaataaaact ggtgcgttca 3103441 gttttttcgc caatggaata acaggcaatg catcaataaa aatatctcgg ttcaccaata 3103501 tcactgtatt aggatttttc cactggctgt tggatgcaag agtcgcagtt tcgtatcgtg 3103561 aagcgcctgc aaaacgatcc gtaacagcaa cattatctcc agttacttta taaaatcctg 3103621 ttggcgatag actgatgcta gatttatttc caatataatt taacaattta actgagatgt 3103681 ttgagtctgc tgcaaaagaa actgatggaa tcaataataa gattgcagca agtgaacaca 3103741 ctatcaattg tttgcaagat ttcaaaattt caggttcctc cctatatctt agttggcacg 3103801 ttcaatatct tttaacagaa gctgaccctc atcatttttt tcatatgtaa tcgtgacctt 3103861 atctccactg ttaaacttat caagatcact tgtcgattct tcagtgatat caagactaac 3103921 cggctcatta tctactgtta cttctattgt atgagtatca gctaacccta cataagtacc 3103981 ttcttttgtt tcaatgttac tgtctggcga tacatcttca ccttgactct tttgactatt 3104041 aaccccgcaa cccgaaagaa gcaatataaa gaacagtaaa gcaataaatt ttttcatttt 3104101 tttcacctca ttatatttta tcgtcaacct attttatatt ttaaagaaaa attaagaaac 3104161 aatgaaactt ttttttataa aaaacgacta ttttaggatt tcattcttgt attaaataga 3104221 gttgtattta ttggaaattt aactcataat gaaagtaatt taacagacga ggtgcaaagg 3104281 atgagaaacg aacgcagaaa aaagaaaaaa actttattac tgacaatttt aacgataatc 3104341 ggacttcttg tactcggaac tggcggctat gcatactact tatggcataa agcagcttca 3104401 accgtggcaa gtattcatga aagcattgat aaatctaaaa agagggataa agaggtcagt 3104461 atcaataaaa aagatccttt ttccgtctta atcatgggtg tggatgaacg cgacggcgat 3104521 aagggccgtg ccgatacgct catttatatg accgttaacc caaaaacgaa tacaaccgac 3104581 atggtcagca ttccgcgtga cacgtataca aaaattatcg gaaaaggcac aatggataaa 3104641 atcaaccatt catacgcttt cggcggcaca cagatgacgg tagacactgt tgagaacttc 3104701 ctcgatgttc cggttgatta ttttgtgaaa gtgaacatgg aaagctttag agacgttgtt 3104761 gatacacttg gcggcattac agttaacagc acattcgcgt tcagttatga cggttattcg 3104821 ttcggcaaag gagaaatcac gctgaacgga aaagaagcgc tcgcttatac ccggatgaga 3104881 aaagaagatc cgagaggcga cttcggacgc caggaccgcc agcgccaagt catccaaggt 3104941 attattaata aaggcgctaa tatttcttcc atcacgaaat tcggagatat gtttaaagtt 3105001 gttgaaaata atgtgaaaac gaacttgacc ttcgataaca tgtgggatat ccagtccgat 3105061 tacaaaggtg cgcggaaaca tattaaacag cacgaactaa aaggtacagg cacgaaaatc 3105121 aatggaattt actactacca agctgatgaa agcgcccttt ccgatattac aaaagagctg 3105181 aaggaaagcc tcgaaaagta aaacaaaaag aagcttcgca caatgtgcaa agcttctttt 3105241 ttatttgcct gtaaatgaat ccggttgttc ttttcgatac ccgtaatgaa acagcaattc 3105301 ttccacaatc cggcgggaag cctctccatc tccatacgga ttagaagcct gggacatttt 3105361 cttgtactca tcaggatcag ttaacagctg ttttgcaagc tgataaatgt tttcctcatc 3105421 cgtacctgca agtttcagcg ttcccgcttc cactccttca ggccgttccg tcgtatcacg 3105481 cagaacaaga accggtttcc cgagagatgg ggcttcctcc tgcacgccgc ccgaatcggt 3105541 caatataaaa tgcgatttcg ctgcaaagtt atggaaatcg atcacctcta aaggttcaat 3105601 cagatgcact ctgtcagaat caccaaaatg cttatgagcc gcttcccgga caacaggatt 3105661 caggtgcaca gggtaaacga cttgtacatc ttcaaattcc cctacaattc tgcggatggc 3105721 cttaaacatg ttttccattg gctcacccaa attttcccgg cggtgagcgg tcaagagaat 3105781 cattttatcc tcacccacct gatcgagaac aggatgtgag taaccatccc taaccgttgt 3105841 gttgagtgcg tcaatcgctg tattgcccgt tacaaaaata gagtcggcct ttttgttttc 3105901 ttttaataaa ttgtctttcg cctggcctgt cggagcaaaa tgcaaatcag caatcgcccc 3105961 tgtcatctgt cgattgagct cttccggaaa cggggaatac ttattccctg tacggagccc 3106021 cgcctccaca tgaccgacag caatttgatg gtaaaaagcg gctaggcttc cggcaaacgt 3106081 cgtcgtcgta tcaccatgga caagcacaat atcgggtttg atatctttaa acaactcatc 3106141 caatcttaca agtgcgttag acgtaatctc tgccagtgtc tgccgctcct tcataatgtt 3106201 caaatcgaag tcaggcttga tgtgaaacgc atctaacacc tgatcgagca tctgtctgtg 3106261 ctgtgcagtt accgttacat aggaatctat ttcaggatat tttttcaatt caagcacaag 3106321 cggtgccatc ttgatcgctt caggcctggt cccgaaaacg gtcatcactt ttagtttttt 3106381 catatttgtc acctggtttt ctgctatagt aaataaattc atactacata ttctacatga 3106441 aaatgcatca ttttaaatca tttcattctt gattcaaata aaatgatata agttttaata 3106501 ttaaggataa agcttgttta aaaatggttt atccgatatc ataaaaatgt gtaaaaacat 3106561 attgaaaagg gtaaatagag aatagtttaa ccataaattt tttcgatcat aaggaaggtg 3106621 ccttttaaat gaaaaaagta cgtaaagcca taattccagc agcaggctta ggaacacgtt 3106681 ttcttccggc tacgaaagca atgccgaaag aaatgcttcc tatcgttgat aaacctacca 3106741 ttcaatacat aattgaagaa gctgttgaag ccggtattga agatattatt atcgtaacag 3106801 gaaaaagcaa gcgtgcgatt gaggatcatt ttgattactc tcctgagctt gaaagaaacc 3106861 tagaagaaaa aggaaaaact gagctgcttg aaaaagtgaa aaaggcttct aacctggctg 3106921 acattcacta tatccgccaa aaagaaccta aaggtctcgg acatgctgtc tggtgcgcac 3106981 gcaactttat cggcgatgag ccgtttgcgg tactgcttgg tgacgatatt gttcaggctg 3107041 aaactccagg gttgcgccaa ttaatggatg aatatgaaaa aacactttct tctattatcg 3107101 gtgttcagca ggtgcccgaa gaagaaacac accgctacgg cattattgac ccgctgacaa 3107161 gtgaaggccg ccgttatcag gtgaaaaact tcgttgaaaa accgcctaaa ggcacagcac 3107221 cttctaatct tgccatctta ggccgttacg tattcacgcc tgagatcttc atgtatttag 3107281 aagagcagca ggttggcgcc ggcggagaaa ttcagctcac agacgccatt caaaagctga 3107341 atgaaattca aagagtgttt gcttacgatt ttgaaggcaa gcgttatgat gttggtgaaa 3107401 agctcggctt tatcacaaca actcttgaat ttgcgatgca ggataaagag cttcgcgatc 3107461 agctcgttcc atttatggaa ggtttactaa acaaagaaga aatctaaaca aaaaggctat 3107521 tggacattca tccaatagcc tttttttatt tcaacatcaa agtcaatgta tgctcttcat 3107581 tatcaactgc gaagacctga tcaacggcct gccgcaaaaa ttaataatcc cagacaaaca 3107641 cactgattgt agagttaaac aaactaaatg aaaacataaa tacaaacatg cagattaaat 3107701 agtaaatatc ttgtattcaa tgcaagctaa gtaaacacca cttgctaaaa gaacaatgac 3107761 taaacaacca gcattacaaa ataattaaat aaatttgaag caattacaac agaaggcagt 3107821 gaactgtcgg aaagttcatt ttggctacca tattaatccc tttaactacg ctgttggatt 3107881 tatcaagaat tgtcgggcta atagaaaacc acggaatcaa accagccagc attcaaacga 3107941 taaaaggcac ttctccgata cctgttatga ccagcttact gttgcgcatc ccaaatacaa 3108001 accagtacgc catcattaga ataaggggat ttaaaacctg ccataataca ccaaaataat 3108061 tgattttttg gatctttcgg ttaaagaaat ttaaaagtac cagtgaatat tgtaacaaat 3108121 gttgagtttt tttcactttt aaaaagtaaa gagaagtctc gcagaacttc tcccaacatt 3108181 tgaagtgtca atataaaaca aaccaacctc atttagcaac tttattatta tctaattcca 3108241 aaatagcatt ataaatacga ttcctattat ttttatcagt atatgcaaaa aagttatcta 3108301 ctctttttct atacttatct tccatacgac tattgttttt catataatag ataactttat 3108361 ccactaagct attatgattt tctaatacat caccaaaccc cattttttta taatcataat 3108421 aatcaagttt aaaatggtat gacttttcgt attgataata aataacaggt tttttctcat 3108481 atgcaaaatc aaacgcaaca gatgaaaaat cagtaatcat tatattagaa gaattaaata 3108541 gcatttgata gctgctgtta tagtcggcaa actccacata atcatgcttt tcaaagtcta 3108601 caatctgttg ctgaatatct gggtgaggaa aaaaagttat tttataatta tttttcttag 3108661 caaattcgat tagccgttca tcattaatca aagcattata cctagaaaaa tattcactat 3108721 ctttaaattt cgggttgtac ggtcttactc cttttgcctg atctttcggt aatacaatat 3108781 cttttctcca agtcggcatt attagaagtt gcttttctcc ctcactcttc ttaagattat 3108841 cgtatctcgg aaatccaccc aacaaaatat tctctttttt atagttgtaa ttccctttca 3108901 caatagaccg atattcaggt ttggcagaag tgactaataa tttgatattc ttgttgtatt 3108961 tgtttaacca ttcagaatga tctgccattg ttattccgtg ctgtaaaaag ataaactcaa 3109021 agttaaataa atctctaaaa taaatctcca tattaaaaaa tggatttaca acccatatat 3109081 ctgcatgtgt cgatattact ttggaagagg ataaggttaa aattttatgt ctaaaagatc 3109141 tgtatggtat gacctttcca tattttttga ttctgtcgta atccttgcta tcttttttta 3109201 ttataaagta tttttttacc ccatcattct tgttgattgc atatttaaag aggtgctcgg 3109261 cattatcatc agctttgtct tgtctgtcta tgaataacca tactggtttt ctattaaaaa 3109321 tagtgaaaac atggtgtacc attcttgcca tcagtgcctt cttaatcgct gattttcgtt 3109381 tttttgattt ttcccctgat ttatgtaggg attttaagaa acgaaactct tttataaatc 3109441 tatttttaaa attgtttttt ttgaacatta attttttata attataataa aaaatataat 3109501 cttttttagc cacataagta ttatataaat cgtttgacaa acctgaatac ttgaaaaaac 3109561 gaagttttgt caacttcctt tttttaccct tagttataaa aaactcaata tgatgattat 3109621 ctgctagatg acctttggga atatctattg aaaaaccggg atattttttt attacttctc 3109681 ctaaacttat ataatcatta tgctgtcttt ttatattctt tgcttttatt tttgtttcgc 3109741 caattttagc ataaaactta aaacctttag aattaaacag cgagctccaa aagccttcta 3109801 tgtgaatgga atcctcattt tcttctaaaa tttcaatagt taaagtttga tccgataatt 3109861 tcgaaacaat tttaccttct ctgtataaat aataatcctg ttcagtttct ctttcatata 3109921 catacctact ataattttca ccgtgcttta tttttaaagc atgatataaa tagaaatggc 3109981 tgacactttt tgtttcaatg atgacatcgt cgtcaatata cgacaatact tctcgaatca 3110041 atgttaaaaa ttcactgtat tcattttcgt ctaaaggtgt ttcactgata tccttaatca 3110101 ataatttcca cttcaaatca tgcataacca tatattgaag aaataaaggt attttctgtt 3110161 catgattttt tataatatcg attaaattct ttgagaaagt gataagtgaa tggttaaacc 3110221 aattcttatt tgctttagca gtctgcatgg cagatgatcc atcttctcta actctataat 3110281 ggtattttgc ctctttaacc agaccatact ttttcttttg cgatatgatt aaattaacta 3110341 gtttggcatc ttcacctatt ttacaatttt catcaaacct gatatttttc aaggcatctt 3110401 tttttataaa tgtagaacaa caatgagtta atatatgatg cggttctttt tctacatcca 3110461 aaattcttgt agaagaaaac ttattattta gattatgttc tccagttctt ccttctgcaa 3110521 aaaaaatagg gattgctaca atatcaattt cattcttatg ttcgtcaaag aagtttaaaa 3110581 cattttcgaa tgttccttct gaaactaaat catccggatc caaaaattga atatatctac 3110641 cttcagcata ctttaaacca taatttcgag cactgctcac tccgccattc tgtttctttg 3110701 catagacaat gttattggga tatttctgag catattcttt acaaatgatt tcacttttat 3110761 cggggctatc atcattcacc agtattaact gaatattctc aaaaccaata gtttggttaa 3110821 tgatactttc tatagcttca gtgagataca actcaacatt ataaatcggc attataacac 3110881 tgaaatcata gttaaaactt ttttcgttca taaaagatta ctcctaacat aatgtttata 3110941 tgaataagaa ttcgggtaaa taaaattaag aaacaagaga gtactaattt ttgcaaaaca 3111001 attttaattt agtaaaatgt atgaaaagca ttccttacct ttttttaaaa acccttgtaa 3111061 gcaaactttt aaaaatgttc acatggttaa gttctaaaga atcatttggt gtttttagta 3111121 caaagtcaaa tgcaaaggcc caaatcggta tttcgacaac aaaaccagca tatctaaaat 3111181 ctcttaattt atatccccat acttcaattg tttttttcag ttcttttcgt ttgcattttt 3111241 ttaatctttt aaaatatttt atatatattc tgtcattttc tttcatctca taatactggt 3111301 taataaagtg ccctgttaat tcaagtctaa gcccttttat ttttgccgaa gtaacagtac 3111361 atgaactatg cagtactctt tcttttttta tattttcaag agcttctgta ttttctttta 3111421 ataagtgaaa cataaattct ttatagtaca tcggcatatc ttgttctttt ataaattgcg 3111481 ggtcaataaa ttttaaaact ttaataaaat catcaacaaa aactctttgt tcttgttgat 3111541 ctaaaacaga cttataaaca tctctatagt tcggatataa aaacagtttt atatgatata 3111601 caattaaaaa ttgcaaataa ggcaaaacta tatcatattt gttgaatgaa tccatcaaca 3111661 aagtcatgta acattcattc aacaaatatg tgtacctttt tttgttaaac catgaacgat 3111721 caactaaaga atcctgttct ttccgttttc tataaaaata ctttccttct gcaactgctc 3111781 cgtatctttt ttctttcagt aataactggt taaaaaagat agcgtcttcc caaaacttta 3111841 tagattcatc aaaaaggacg gtactagtta gtgtatgtct tctgtaaaaa gtgccgccaa 3111901 tataaaaatg aatagcttta taatcgttga gaatatttat aactcttgtt cctttttcaa 3111961 atctattatt taatttatgt cccccttctt tttcacctgt gtaataaaca ggtaataccg 3112021 caatatttac atgttcggaa tcacaaaaaa aatcataaac actttgcagc gcattttgag 3112081 agaatgcatc gtcagaatca agaaaaccaa taaatttaga tctttcgctt acatttgata 3112141 atccacaatt tcttgcagca gaaggtccag agttttcaat tttcatgatt ttaatattat 3112201 taggatatag atttttaaag gattcacaaa tttgaggact gctgtcaaca ctaccatcat 3112261 ctattaatat cagttctata ttttccttaa atccaattga ctggttaagg acactctcta 3112321 ttgaatatct taaataattt tcagaattat atattggtat aattatagaa aacatgtttg 3112381 tacctcttta tttagaagtt aaaggatcgt ttcaattact cttttagaag ccttgcctct 3112441 tctaaattac aaaatttatt ataaaaatcc tcatagttat gatctatata aggattatgt 3112501 aacaactctt ttaccgtatc tataagttct tcacttgttt gaagcaagtt tcctggcgtt 3112561 ttttgctgaa aattaaagta aaaacctctg atacagtctc tataagccgg gagatcatac 3112621 acaaaaaata caaggttttt ttaaaaattc atattatcaa aaaagacaga agaataatcc 3112681 ataatcaata aatcactaat taaatataaa tctcgaatat ctttatttaa agaaacatcg 3112741 ttcacaaaat atttatattt ccctaattaa attgttctga aactggataa taccattctt 3112801 acaagaataa ccatagagtc tccaaggttc cctcttcatt tcctctaatc aaattaaagt 3112861 taaatttata ctggccagct ttcttaaaat tcattatccc gcaaagttgg tgcatataaa 3112921 attatttttc tttaattcct tatttgataa tgtagaattg gtaggggatt gtagctaaac 3112981 tgtttccaga atagctttca aataaaatta atttattgtt tcttggcaga aggacaaaaa 3113041 ttttaaacaa aactgaataa actctaacta gtaaacttct gcaattggtt ataataaaaa 3113101 tttcatcagt gaactcctta aagagtgaag attaatattt acgcaaacaa gaaaaaaaga 3113161 agcaactgaa tttacttcaa gcctctttta gttagtgctt ctataaacta gccatatctt 3113221 ttctgatttg ggtagttgaa atgcctgcta ttcttgtaag gtaaatggcc tcatagtatt 3113281 cctttgtaga caatcgtacg attaagtaat cccaggttct tttgctcttt ccagtagctt 3113341 catatgtcca tagtgaaata aatcaaacat tccgtacgta tcactttctt cattagataa 3113401 catcaccttc caaccttttc caacttagaa aaaacaaaaa tccttaactg attgtttatc 3113461 atttcgacat attttttacg ttccattaat aataaacaat aatagcatat gttcctataa 3113521 aagttaaggc tctttaaaaa tgtaaatcat cagcactttt tgacaatatc gttgcattga 3113581 tgtgtatttt ttacagatct gatatcttat ctatactcat tacaacaagt tttctattcc 3113641 ggaagagtca attctttttg tcgcgttttc aagtgtaatg attttctttc tgctgcgtca 3113701 tttattttgt acgccctcct catattactt catcgtcaaa acgtgaagga attgtaatac 3113761 gtagttccta aaaattttcg tggtaaaatt tagtgaagtc tttatcaggc taagggactt 3113821 tatctaaact acgaattaca tatggagata tatagatgaa aaggagggtt gatatgatat 3113881 aaacgaaaat caattagata aaggaaaaac tgaacacttc tgaaaaaagt gataagtttc 3113941 tttcactata tcctccaaaa agaacctaaa ggtcttggac atgctgtctg gttcgcgcct 3114001 aactttatcg gcgatgagcc gtttgcgttt ctgcttggag acgatattgt tcaggctgac 3114061 acaccagggt tgcgccaatt aacggatgaa tatgaaagaa cactttcttc tattatcggt 3114121 gttcagcaag tgcctgaaga tgaaacacac tgttatggca tcatcgcccc gctgacaagt 3114181 gaaggccgcc gttatcaggt gaaaaacttc attgaaaaac cgcctaaaga cacagcacct 3114241 tctaatcttg ccatcttagg ccgttacgta ttcacgcctg agattttcat gtatttagag 3114301 gagcagcagg ttggcgccgg cggagaaatt cagcttacag acgccattca aaaactgaat 3114361 gaaattcaaa gagtgtttgc ttacgatttt gaaggcaagc gttatgatgt tggtgaaaag 3114421 ctcggcttca tcacaacaac tcttgaattt gcgatgcagg ataaagagct tcgcgatcag 3114481 ctcgttccat ttatggaagg tttactaaac aaagaagaaa tctaaacaaa aaggctattg 3114541 gacattcatc caatagcctt tttttatttc aacatcaaag tcagtgtatg ctcttcatta 3114601 tcaactgcaa aaacctgatc atctgtattc acaagaaaac gcttcttgct gctgtcatac 3114661 aatacatcgc tatcacttaa ggatagtgac gccgggttga taggagaaat gttatgaaaa 3114721 ataagctctg ttgctttatc attctccagt acataactga ttttttcata atcaaaattc 3114781 agcgtttttc tgccgtcagc cttatttcct tcagtataac cattcaattt cgattgaatg 3114841 ctggtgctgc tgtctcctag gaatttcaga aagtattcat aggaagatgc tgcgttttgc 3114901 gagacataag acgtaaatgc agtggcatgc aattcagcgt gtttcatgtt agttgcaaca 3114961 gcgctctgtt tcacataata agagtgcccg tcaaacttta ttttcgctgc ttgtttgcct 3115021 tttgcagcta ccgttacttt tgtaccgaat ggcagtgtaa cgtcagcctt ctgtttcaaa 3115081 ccctgatcct tataagcagc cgctttttca tttgctataa acccttgctt attgattgca 3115141 gttaagcgtt cctctgactt gccctttgca tcgccatgat ggttcttcac ttcattttgc 3115201 ggaatagcgc caaacgaagc aattgtacga agcggggcat taaagaacat cgttcccgcc 3115261 atgaagacag tcagaataga caaaatagca atttgaatgg cattggccag tgatttcggc 3115321 tttttcttct ttttgcggaa acgggcaaac gcttcaggat cttctttctt cctctcttct 3115381 gtctgctctt ttttatatgt ctctttttct tttttcgata gcttattaaa ccagtcaata 3115441 aacgctttgt actctttcac aaccgttttt gtttcatcaa acatacgaag ctcgccatag 3115501 tgcatccaag caacacggtc acacatcttt tcaatctgac cgattgagtg gctgacaaag 3115561 aaaatcgttt ttccttgctt tttaaactca tttattctgt ctacacactt ctgataaaac 3115621 gtttggtccc ccacagaaag agcttcgtca ataattaaaa tgtcaggatc aatatgcacg 3115681 gagatcgcga aaccgagacg cgacttcatc ccgctggaat agtttttaac cggctgatta 3115741 ataaaatcgc caatctcggc aaattcaacg atgctgtcat acatatcatc aatttcttta 3115801 ttggttaacc ccatcatcaa acacttgagc cggacattgt cccggcccgt taattggtta 3115861 ttcaaaccgg cagcaatcgc aatcagcgac ggctggccgt tcatttcaat ttcaccgctg 3115921 gtcggcggaa taattttagc cagcaggtta gacatggtcg attttcctga cccgtttatt 3115981 cctacaaagc cgattgtctc cccttcatac acgtcaaagg agacattccg cacagcaaaa 3116041 aaaccattat ccttagccgg aaaaaacaat cctttaatct tgtccgattg ttttttatac 3116101 aaatgatact gctttgaaac atttcgaaac gaaactttta gtttcatcgt aaaatctcct 3116161 tacgtattaa agaaagtcaa caaacttgtc tctgaatttc atatgcagga tagaacctac 3116221 taacaataaa aggaatgtga acaaccaaaa gtacagcgtg tacttcatgt catggaaaaa 3116281 ccatgctcca tctaagaagc tgttccggaa tccttcaata atatagaata gtggattcaa 3116341 cttcagaaca ggcactaatt cggggtggct ttgaccgagt ttcgcattaa catcccaaaa 3116401 aattggcaac aagaaaaaca aaagtcttgt tacggcctgc agcaaaaatt gataatctct 3116461 aatcagcaca ctgatcgttg agttaaacaa actaaacgaa aacataaaag caatcataca 3116521 gatgaagtaa taaatatatt gtaaccaatg cacactcggg aacacaccat taactaggag 3116581 tacaatgata taaatcacca tcatgatcat ataactaaat aagttagatg caattgccac 3116641 ggacggtaga gaactaatcg ggaagttcat tttagccacc atattaatgc gcttaaatac 3116701 actatttgat ccatcaagta tagttggact gatgaaaaac catgggatta atcctgccag 3116761 catccaaata ataaaaggca cttcgcccgc tccggttgtc acaggaccgc cctttctaat 3116821 ccccatacca aatacgaacc agtaggccag catttggata agcggattta agaactgcca 3116881 taagacacct aaataattca tttgatattt agacttggtt tcataagccg ccaatcttaa 3116941 aattaaagga aatgacgtta tttgctctct gagtatacgc aacaaatcat tcatttttta 3117001 tcttccttag acttaattgt ttttgggaat ctttctgttt aaaatttgaa agcaccgctg 3117061 attattgtaa cagatcctgc attttttttc acttctcaac aagtatctaa aaagctgccg 3117121 aaaaatcgac agctatacat tttataaaat aacctaaatt attcagcttt aaatacagta 3117181 ttaacaacct tttcagatga acgtcctgac tctaaatagc aaaacttatc atagaaagga 3117241 ccaaaagaaa ccggaagctt ataatcaggc gatgagatct gcttgatagc ctcaatcgtt 3117301 tcttcagtag tttttaccaa aggaccagga gcttcttttt caaaatcaaa gtagaaacca 3117361 cgcaacttgt cccggtaggt ttcgatgtca gggacaaaga atagcattgg ccgttttaaa 3117421 tttgcaaaat caaagaatac tgaagaataa tcagtaatca gcaaatcaga aaccatatac 3117481 aattctcgaa tatcctcata agcagaaaaa tcatatgcaa atccttcaaa aggacctaaa 3117541 tcaaaattct cagctaccag ataatgcatt cttaagatta caatatattc atttccaagt 3117601 tcttgtctaa gttgatgcaa atctaaatcg agatcgaact tataacgccc ttttgcatag 3117661 aactgatcat ctctccatgt aggggcatat aaaataacct ttttatcacg aggaatattt 3117721 aacctactct ttatcaatga tattgtttcc tcattattat cattatgaag aaaatcattt 3117781 ctaggatatc cagattcaat cattgtcttg ttaaactgaa acgcccgtgt aaagatctca 3117841 gttgaataac catttgggga aatcaagtaa tcccaattag aagcttcctt gataaaattc 3117901 cttttatatt ttttggtgtt tgtaccaggc atatggactt cttccatatc cattgcaagt 3117961 ctttttaaag gtgtgccatg ccatgtttgt aaatatgttg tatgactagg tttcggaatc 3118021 cataatggaa gccggctgtt aacaacccaa tactcagctc ttgccatagc gaagagccat 3118081 tttaatgaga ggcgattaat gtaaggaatt cccttttcat caaaaggcgc tgaatattgt 3118141 ttatttacac tccaatacat tttatactca gggtggtttt cccgcatata ttcgtaaatc 3118201 gctctcggat tacaactgta ttgtttccca ttaaaacttt caaaaatgac tgttttcctt 3118261 ttaactggca ttctgctagc catcatgaat agagatttgt atgttttagt gattaacttg 3118321 tttctcattt ttgtgatctt ttttattttt gatactaatc tcttcttctt tcctttaata 3118381 aagtatttca tccttgtttt caggctatag tcgtttactc tgatacctag agtctgcttt 3118441 ttctttttct taaagacttc ataacgaact ggtgcgttgt ttgttttaat aatacttact 3118501 aatcctttta atttgttttt tcgatctcct aaaacaagag cagtgctgtt gaactgaata 3118561 tccgttcctt catcgtcatt gcatatatac tccataaaaa gacgataaac ataacgtttt 3118621 tcatttgaga aaggaatttc tttcaaaggc actttcactt caaaatcata cagttccgga 3118681 acaaaaccat ctgctctcat gttttccagg ccatgtgttt ttctttctag cttgattgga 3118741 aatttttcct caataggtgt ttctccaccc ttttttaaaa taaggttcaa gttttttatc 3118801 cgatattgat tttcggaact caggtacccc gcataacctg ttatgcttat ttcttcagag 3118861 ctaatctcga tttgatcaaa tctgatgatt ttggcctctc ttttcacctt aatagaaaag 3118921 ttgcctttat cagttgtata aggtaaaatc aaaagttctg tggtttgatc gacatgaaag 3118981 gcgcgctcaa ttgaatttac ttcagcagaa agacgcttca agagtggttc ctgctccgca 3119041 tcttcatatt tttttcgaaa ttcgacataa aaatcatatg tttgtcccat ttcaacaggc 3119101 ataggcaaaa catgagcatt tatctcagtt ttatactcta atgagccagt gttttgaagc 3119161 ggaaattcag attccgttcc tgaacgtctc tctttcagct ttaaaaataa ctggtaatcc 3119221 tctaaaaatt ggtgttctga atcaattgag attaacaatt caagacttcc taaattgttt 3119281 ttcaagcttt tcaaaataca tttaatcaca gtgttttcaa tcattacttt tttctgctcc 3119341 tctgtataaa agctctttcc tttttgcttc cttttattag tgtcaactac taaggacatt 3119401 aactctcttt tatttccgtg accctccaag agaaattgcc tttaactgtt gtatagggct 3119461 ctactctata gccattatta gtatctatac tgtttcctga caattttgtt tcttcactcg 3119521 aaagtcttcg cattgtttta atatggccat ttgcattgaa aacaatataa aaatcaataa 3119581 cttgggtttt attagcagct atcttttcaa tatttacatc tttttcgaga tcaattacaa 3119641 acagttgatc attttgtaag tttgttgaaa taatttcagc cttattcttt ctgtccaagc 3119701 ccactaaacg tattttttta atatcattat gatcaaaatt ctcaatgtca atttctattt 3119761 tagttttatc aaaatcctca gtataggaac taatagaagg atcttttttt ccaacctttt 3119821 tagagaactt ctctctttct attcgcacct caatcatctg attaagagca aaagcccaat 3119881 tttcaatata gttgggtctt gaatattttt cagccatttt aaaagcttgt tctgaaaatt 3119941 tttgatgagt actttcatct ttcatcaaag agataatagc ttgacccaat ttctctatat 3120001 tatactgttc aatgacatat ccatttgctc cgtcagtaac taagctcctt gctccgtaat 3120061 cataatcgta tgttacaact ggacatccat tgctcagtgc ctccatattt gatagaccga 3120121 acccttcaaa atgagaggtt gaaatggtta gccaagcttt ttgaaactct gagtcagggt 3120181 tatccgtata gcctttcaaa aagacattgt tctgcagttt ggtatcttca atttcttttt 3120241 ttattttttc gaaatcttca cccgatccga atatatcaag ttttgcttca ggaatttctt 3120301 tcacgactaa actaaatgct tttactgcat gtatcagatt tttcatagat gcaagtcttg 3120361 aaataatgac agctttgtat ttttcactcg gcacattcaa tacagcggga tcaagaggct 3120421 tatcaattgt atgcggagta aagaaaaacg tctcttgttc ccctgaaatc aatttaaaat 3120481 cttctagctg ctcctcagtt ataaaaaaga cagcatccaa attatacatc tgactaaata 3120541 cttctttata gcgaccctta atttgatatt tattgctgcc gtaatgcttg ttatgaataa 3120601 ttgctccata ataggaagaa ggtgattttt tcactttaaa gacatgtttg tcttgcggtc 3120661 tgctgtccac taaaaacaac ttaggtttat cattttgttt ttgcagatat tctatccaat 3120721 attgacgcag ttccgattca tcttttactt ttatctcacc ctcaagggag taccaaataa 3120781 tatgagataa ttgaacatct ttttcttcat tgttccatac atagagtttg tctaaatata 3120841 cttgattttg gtcattaata tattcctgca gatacatctt gtttagctgc acatcataat 3120901 gagtaacgag aactaagttt ccgttcttcg tatattcctc tctctttatg agctggtttt 3120961 tatcattcca atagtcgacg taccggatag tttctccatc tccgtagtaa actacagaca 3121021 tttcattgtt cttcttacca aacaatctca acagagtttt tgcaaatttc cccattccaa 3121081 cttgcttttt tatctggtca aggcctatcc tttcttcgta tgatcttttc ccatttgttc 3121141 taacacttaa aaaatcatcg aatagattaa taacacttgt gaatttttta tcaatcttac 3121201 cgttgctgta caattcatca atttttgaag acaactctaa atcaaaacga aacgttaaga 3121261 aaaaggtgtt ttggttacac tcttctccaa ataattttga acgcaataat aatgatttcg 3121321 tcagaccgcc ataattactt ggcagtccac cagagataaa ataataatcc atgtcaggaa 3121381 tttgttttat attagattca ctcaccgcat gtaaagacaa ttttttactc cctttcggca 3121441 tctagaatat atgatcattg aaatttatat ctacccggat actttagtca caaaaatcaa 3121501 tgtaagcatc aaaaagtact tcttatttca ataagaagta ctttaattag atattgaacc 3121561 aatgatatca ggatcctaaa ttataaacca gcaatttcct ctttgatctt tgttgtagag 3121621 atgccttctg ttcttgggag gtaaacaacc tcacactgat ctttgagaaa gtcaaattta 3121681 ccttcccagt catcccccat aacaaaaaca tcaatattat gatcaataat atcttgcttt 3121741 ttttgctccc aattcttttc aggaattact tcgtccacat atcgaatggt ttctaaaatt 3121801 aatttacggt gctcatagct gtgataagct tttttttgct tttgtaaatt gaattcatcc 3121861 gttgaaatag caacaactaa ataatcacca agctgctttg cacgctcaag caatttaatg 3121921 tgaccccaat gcagtaaatc aaaagttcca tatgtgataa cttttttcat ttaaagaaac 3121981 gctccttcct aatgttaaac actattaaaa acactactga cgttagcgat taaattctaa 3122041 aaacctgttt gtattcctta tatcgacata tttctcgtat gtcttcactg atcattaatt 3122101 atagcatacc gcctaaaaaa ggttaagtac tcatgaggag aaaaacattc caaaatatgt 3122161 aattacactc agactccatt ggcaccaagg tctgttgttc attcgttcat tcaattgtaa 3122221 aattggaaac atatttaaat ttaatgtaaa gataatgtta atcctttgtt gaagatttat 3122281 gttaaaatat aaggtagctt gattttgctt ttagaaactc tcggttttta actatataaa 3122341 tagaatctta aaggaaggag gagccagaca tgcaaacaga gactattcac aatattcctt 3122401 atgttaacag taacttaaca tcatttatcg attacctaga gaaacattat attgatcaaa 3122461 agattggtgc tgtcatttcc acagtcaacc ctgaaattgc atttgcagct attaaagatc 3122521 gggactactt tgatgtacta tcttcttcaa acttcatttt gcctgatggg atcggtgtag 3122581 tcatgatgtc acgtttgact aacaacaggc ttcagtcccg aatcgcaggt tacgatgttt 3122641 ttaaagaact tctgggcgtt gctaacaaaa agaaaaaacg catatttctg tacggtgcga 3122701 agaaagatgt tataaaaggt gttgtatcca aaatttcttc tgaataccca aacattaaaa 3122761 tcgcaggtta ttcagacggt tatgttcaag atcgcaccct agtggcaaaa caaattgcaa 3122821 gagcaaatcc tgacatggta ttcgtagctt tagggtatcc tcatcaagag aaattcattc 3122881 ataactacag acacttgttc cctaaagccg tatctatagg tctaggagga agctttgatg 3122941 tatttagcgg taatgtcaaa cgggcccctt cctggatgat acgtttaaat ttagaatggt 3123001 tctaccggtt aatcttgaat ccatggcgat ggaaaagaat gcttagcatc ccaaaatatg 3123061 ctttaacggt tttaaaagaa gaaaaaaaca aaaaaacttt ctatccaaag cctgaaaaag 3123121 atcatacaaa acagatttaa aaacaaaact ttcaaataaa tggatgataa aaatgaaaat 3123181 aagatcacta ctggcgaatt gctatttgta ttttttatca gcaatcgcct tttttctgca 3123241 atgggtgaaa cctgaaagca aagtgaccct cctgatctca ttcgaagcaa acgcaaaagc 3123301 gattcttgag gaatatgaac aaggacaata ctcttataaa cttaacatcc tgtataccca 3123361 gcaggcctct gctattgccg agagcttccc gaatgtagat gcatatttat tacaagaaaa 3123421 aaaccctatc catctcatta aagctgtata cctaatgttt aacagtaaag tgatcataac 3123481 agataattac tttctattaa caagtgtgtt aaataagcgg aagcaaacga aatgtatcca 3123541 agtatggcac gcaaatggct cactcaaaaa atttggtttg gaagacatta caaacatgca 3123601 acggacgaaa actgatatta aaaggttcca aaaagtatac agttcgtatg attatttaac 3123661 tgttggctca gaagagatgg caaatatctt caagaaatca tttggaataa aggataacca 3123721 attattaaaa ataggtgtac ctttaacaga cccttattac cgagaaaaca agaaaaaaat 3123781 ttcagatact ctaaacatac aaagaaaaaa aataatcctc tatgcaccga cgtttagaga 3123841 ttataatatg caatcaattc aattgccttt tacagaagaa caattaattc atcagttaaa 3123901 agaagaatat gttttatttg ttaagctgca tcccgccatt cagaacaata ttgatattaa 3123961 atattccagt gattatatta aagatgtttc taactatgcc ttgtttgatc tactcatggc 3124021 tgcagacata ttaatcactg actattcttc tgttcccttt gaattttcga ttttaaataa 3124081 acccattctt ttttatactt acgatttaaa actttatcaa cagaagcggg gattggttga 3124141 taattatctt tccataatac ctggaagagc ctgctatgac agtgaatcat taataaatga 3124201 aattcaaacc ccatttaatt attccaaaat aaaagttttt tccgatagat ggaataagta 3124261 ttctgatggg aattcaagcc aaaatttatt gaatttcatc gaaaatttaa taagctaaat 3124321 gatgacactt gttcaaaaca gaacaagtgt tcttttttct attgaatacc gaacgtatgt 3124381 ttgctttaat gtaattagtt gcttatggca gcaaataata atagaggtgg taaatttatg 3124441 agaaaaaaag aactgtttga tttcaccaac atcacgccaa aattatttac tgaactacgt 3124501 gtagcagaca aaaccgtact tcaatcattc aatttcgatg agaaaaacca ccaaatttat 3124561 acaacccaag tcgcaagtgg attaggaaaa gacaacaccc aaagctatcg cataactcgt 3124621 ctatctcttg aaggtttaca attagacagc atgctgttga aacatggagg tcatggtaca 3124681 aatattggaa ttgaaaaccg taatggcacc atttatattt ggtctctata cgataaacca 3124741 aacgaaacag ataaaagtga attagtttgt ttcccatata aagcaggcgc gactttagat 3124801 gaaaattcta aagaacttca gcgattctcg aatatgcctt tcgatcatag ggttacacct 3124861 gctcttgata tgaagaatag acagttggca attagacaat acgatacaaa aaataataat 3124921 aataaacagt gggtgacaat ctttaacctg gacgatgcaa tagcaaataa aaacaatcct 3124981 ctttatacta ttaacattcc tgacgaactt cattatttac aaggtttctt tttagatgac 3125041 ggttatttat attggtatac aggagataca aacagcaaaa gctatccgaa tctcataact 3125101 gtatttgatt ccgataataa aatagtgctg caaaaagaaa ttactgttgg caaagacttg 3125161 tccaccagat atgagaataa cttccgtgaa ccggaaggga tctgtatgta caccaatcct 3125221 gaaactgggg caaaatcatt aatggtggga attacaagtg gaaaagaagg aaatcgtata 3125281 agcagaattt atgcatacca ttcttatgaa aacttcatga atcatgtacc tatgcttcga 3125341 tcccctttat taaaaaccgt ggggcaccaa gatacacctc cagaaagatt tcaaccattt 3125401 attcaaacct tcattttaga gtataatgct caaaacaaaa aatggatggt tccgacttca 3125461 ggttatttac catcttacac atcaaattta gtccgaaata ttactatcaa tgcagatgga 3125521 aacttgcaag tcacattaaa tgaacgctat attagtttac tgcatcaatc gatagaagga 3125581 gatttccgct taaaacaaaa ggatatccga atgggatcct ggtattttgc cggcggagaa 3125641 aaatcaaatg tgcttgaaat aggttttatg aaagggagta caaaaatcag acccgatgat 3125701 gcagccatct caaatgcttc aagaatgagt atttttatga ttgttgcgga caagattgag 3125761 gtgtgataat caaataggct gtagctattt aatagctaca gcctatttgc aactttctaa 3125821 gttttttatc gatattccgg aacatcggcc tactttatag accagcttct ttcggggcaa 3125881 tatgcataaa gaaaagactc cagagattgg agtctttttc ttttattgca cccgtatact 3125941 tcctgcgtat ttatccttcc aatatgtgct cgtgttcata ttggtaatgg tcacgccgtt 3126001 tgataatgtg acatgaacaa cttgtccgtt tccgatatag atggagggat ttaagcttgt 3126061 tgattgaaag aacacaatgt ctcccggctt caggtccgcc ttctcaatct tagttccggc 3126121 attgtactgg cttgttgcgt atcgaggcag ggaaataccg gctgctttct ggtatacata 3126181 ttggacaaat ccagctgtat caaatcccgt ctcaggtgtt actccgccct gtttgtaagg 3126241 cacttctccg acataaagcg tcgcttcgga aacaatcgga ttttctttcg ggattgtcag 3126301 gttgtcaaat cggcgaatac ccgtcatctt cgatttccag taatcctctg acaaatagga 3126361 aatggttact ttttctgacc ggcttgcctg aatgaacctg cctgcgcccg cataaatgcc 3126421 tgcatgtgaa attcccgttt tatacgtatt gctgaaatag acgacatcac caggctttat 3126481 gttctgaggg gctaccttct cgcccactgc ccactgctgt tcggctgatc gcggtagata 3126541 aatgccgagt gcctgttgaa acacatattg cacaagcccc gagcaatcaa agccctctga 3126601 cggcgtgctt ccgccaaaca catatgggac accgatatat ttttcggcct cctgaacgac 3126661 aggaacatca gccgttgccg gatcggcagc gattcgtctc gccccgatat aagttccgct 3126721 ccaatagctg ctttttttgt aattggtgat gataacccct tttgactgtg tactgtgaac 3126781 catttggccg tctccgatat aaagggcgtc atgtgtcgga acagtgccgg tgcttccctc 3126841 tttcttgaaa aacaaaatat cacccggctt caggttttcc ggttttacag ctgttccgat 3126901 tttatactgg tcgtttacag atctcggcag atgaatatca gccttactga acacatattg 3126961 tatcaatcct gatggatcga aaccctcttt cggcgtttcc ccgccatatt tatactgata 3127021 tccaagcagg ttttttgctt cgctgacaat caattctgat gatgtatcag cttccgcaat 3127081 ctccgctttt gtcataattg gaaccaaaaa acaaatgata accgccacaa gcaaaaactt 3127141 cttccagttt gccagtgtgt tcacttttat tatctcctcc tctttttgca gttttaacat 3127201 cggtattttt ttgaatatgt taagagactt tttaatattt ttacagaatg aatatgctgg 3127261 gcaaataaaa agagagtgtc tcatcagaca ctctcttttt tgaattattt attggcgttt 3127321 accggttctt cctgctgctg gattttattc atttccatat caatcttctg tttttcctga 3127381 tctgtcagct gatcattgaa tttaaaagct gacataaaca tgaacacgat ggctacggca 3127441 acaaacggcc agatggcttt gacaaatttc atctttatca ctccgattat ttagatttta 3127501 gtttgtcact atgatcaata tcaaacgtca gttttccgtc ttctactttc caagcgaaat 3127561 tagagtcttt cgtcagttcg cgaataatgg ttttctgttt aaggctgtct tttttcacag 3127621 gcgcaggtgt cgcttcatgg atatcgatcg gtgtcacttc aaagcgtcct gttccatttt 3127681 tcttcaggtg atactgaacc agtgcactgt ctcttgttct cgtccagcct tggtcaaaga 3127741 caaagttgcc gaggctgtag aaaatgacgg ttccgttata tacttcaatc ggttctaaga 3127801 cgtgcgggtg atggccgacg atgatgtcag ctcccgcatc agacatggct cttgcaagct 3127861 ggcgctggcg gtcatttgga tcattgtcat actcttgtcc ccagtgtgac tgcacaacaa 3127921 caatgtccgc atgttttttc gcttctgaaa tcatagggat gaagatttca ggatctgcgg 3127981 gcagcacgcc cggcgtattc tttttagccg cgaaaccttt cccggacaca tcggtaaagc 3128041 caagcgtcgc aatcgttacc ccgttgactt tctggtacga aattttcttt ttcgcatcac 3128101 ttaagctgta tcccgctcca acgatatcaa gattttgctt cgcaaattct ccaagcgtat 3128161 ctttcatgcc ctgaacgccg taatccattg cgtggttgtt ggcgctgttg agaaccgtga 3128221 aattcatatc cttcaagact ttcactgatt ccttattcgt ctgcagatga atctctttat 3128281 ctgcttgttt ataattcttt tgataggtta ccgggttttc aaagtttcct gctacataat 3128341 ccgaggctct aaagatcggt tcaacatatt gaaaaatact gtctgcccct ttttgctccg 3128401 ttactttttc aacatagcgt cccatcataa tatcgcctac aaatgaggct gagagtacgt 3128461 cgtcagaata cgttttgacc ttcggcgttt ccgcttttcc cgcccacatg aaagcgaaca 3128521 taaggacaaa aacgatcgga atggcaataa atacgtgctt attggttttc tttttttgct 3128581 gttttgtcag ctttagcagc ttttcatgaa agctcagttc ttttttcatc gtttgacaca 3128641 ccttacatta aattaagtag taaacaaaca tgatagcaaa ggtcgctccg ctcaatagca 3128701 gcgtgcttcc gaacgtaatg gttaaacctt gtttctgaat ggtattggca attaaacctg 3128761 gcacgatgat gccgattcct cgaaattctg cgatttcaaa tggtacaatc gggtatagaa 3128821 aatcaaacgc gatttttagg acgatccctg ttatcagcat ggcagcgaat tttctgcgtc 3128881 cgtacaaaat cataaatttg gataaaccgt atttcacaat gacatacgtg agcaagctca 3128941 ctagcaaaac aagtaaaata aagaccggct gattaaacac aagtcctaaa tatcccggta 3129001 caacaagtcc tgccggcacg atccctgttt tttccgcaaa aattaaactg agtagtacac 3129061 ctaaaattag tgcgatgtat aaatctgatc cgaacatgtc tgcatttccc cctagcttac 3129121 gagctgcttt accttgtatt cgtggatttt ttcaattaaa ggctctgcgg caccatgaat 3129181 attgccgacg ccatatatga cacggttgtg cattcttttc tttaacaatt ccataatttc 3129241 atctgttgac ttatactcta gatcatgcag tttgtctgca ggaattttgc cttcttcgta 3129301 ggcttttacg atcggttctg ttgtttcacc gattaagatc agttcacttg cttcaatata 3129361 aggcaatacg tcatttgcga attgctgtgt ccgatcgaca cggtctgcgc ggcagttcat 3129421 gatgatgatc ggatcatcgg tcgggtaacc gatttctttt acacgtttcc atatattcaa 3129481 agtagaagaa gcgtcgtttg cggcaaaccc attaacaaag tgcccaggct cgctcggact 3129541 gatcagcgga agaattctca ttgctcccgg atctggcggc gcattcagca ttcccttaaa 3129601 tgctgtttct tcgtcaatgc cgagtgcttg agccacaccc agcgccagag aagcgttatc 3129661 agggaatacc atgtattcaa atttacgtaa atactcatct gtaatttttg agttatcagc 3129721 aatgatgact tttgtgtttc gttcttttgc tttttgttta aagaactcgg tatattcact 3129781 atctgtaatg acaagatggc cattataagg aattgtagca gtaaacgctt ctgcaatttc 3129841 atcaagcgtc ggccccatga catccatatg gtcttccaaa acattcacaa tgacgccgat 3129901 attggcctgc agaagttctt cctgaaagat gatttgataa tctgggttaa cagccatgca 3129961 ttcactgaca atcgcgttag cccctctttc tactgtttct ctcatgactt ctttttgctc 3130021 tccgatattc ggcccctgag gtttccgttt aatcggcttt tcctccggtg tgtcccagta 3130081 aatcattctt gcatctgttc ctgttgtttt tccaacagtc ttgtaaccgg cttctattaa 3130141 tattccggtt gtcagccttg tcacagtcga ttttccgcgg atgccgttaa tattcacccg 3130201 aacagggagg gcatcaatgt ttttctgatg tcgtcgtttt tctaatattc cgatgaccag 3130261 tatgacagca caggctataa tgagtaacca cattgctttt cgacatctcc ttctatattg 3130321 ttgtaaattc attcatcagt atatagaatc actatgaatt ctcaatcggc attatgtaac 3130381 ataatcttcc ctaatcgact aagccaaact tctcttttga aagagatttt atacctacaa 3130441 actgttttct atttttggaa aacagcagga cttatacctt atcacttttt aaaaaaatca 3130501 aagagaatgc gctttcattt ttctcctgat atccttctgg acgtatagtc acaccctgct 3130561 gtttgtattt aatatgcatt tcaaatcaat ctttttttca gcctttgtta tcaagcattt 3130621 cctgctatca tgcgtgtttc cggttcttat gaacacaaaa taattttatc ctgtttctta 3130681 aggacaaggt cataatgtca tcctttctgc atggaataag caatatgagg cccattccaa 3130741 aatgactaag gaggttcgag atgaaaacgc taaacatacg agtccgaatt ctctaacata 3130801 attaaacatt ttctgggatg atagtctttt ctgtttctcc ccatttacag gtctaaacgc 3130861 atgactttga aacaatttta ataaaactta atatttgttc aagaaatctt catccatatt 3130921 tgtgaagact ttgtcaaaaa aagagtgaaa accttaaatt tttcaattat atatacaatt 3130981 tacaattaga tttcttttga tatttttatt gctaacttcg gattgttcat gataatctat 3131041 ctatgtaaac ggttacataa acaaggagga gctgttttgg ctacaattaa agatgtcgcc 3131101 ggagcggcgg gcgtttcagt tgcgacggtt tcccgcaacc tgaatgataa cggctatgta 3131161 cacgaagaaa cgcgaacgcg tgtcatagcg gcgatggcga agctgaacta ttacccgaat 3131221 gaagtcgcca gatctctata taaaagagaa tcccgactga tcggactttt gctcccggat 3131281 atcacaaacc ctttcttccc ccagcttgcc cgcggtgcgg aggatgaatt gaaccgggaa 3131341 ggctatcgcc ttattttcgg caacagtgac gaggaattga aaaaagaact tgaatacctt 3131401 caaaccttta agcaaaatca tgtcgcaggc attattgccg caacgaatta cccggatctc 3131461 gaggaataca gcggcatgaa ttatccagtt gtttttctgg acagaacgct tgaaggggct 3131521 ccttctgtgt ccagtgacgg ctatacagga gtaaagttag ccgcccaggc tatcattcac 3131581 ggaaaaagcc agcgcattac gctcttgaga ggacccgctc acctgccgac cgctcaagac 3131641 cgatttaacg gcgctttgga aatcttaaag caggctgaag ttgattttca ggtcattgag 3131701 acagcttcat tttcaattaa agatgcacaa tcgatggcga aggagctgtt tgcctcttat 3131761 ccagcgacag atggtgtgat cgcgagtaat gatattcaag ccgctgccgt tttacatgaa 3131821 gcattgcggc gcggaaaaaa cgtgccggag gacattcaaa ttatcggcta tgatgacatt 3131881 ccgcaaagcg gacttctgtt cccgccactt tctacaatta aacagcccgc atatgatatg 3131941 gggaaagaag ctgccaaact gcttttgggt atcattaaaa aacagccgct ggcagaaacg 3132001 gcaattcaaa tgcctgtcac ctatatagga agaaagacga caagaaagga agattaagat 3132061 gcgtaatatt tgtgtgattg gtagctgttc tatggattta gtggtcacct cggacaaacg 3132121 cccaaaagcc ggtgaaacgg ttcttggcac gtcatttcag actgtgccgg gcggcaaagg 3132181 agcaaatcag gccgttgccg cagccagact tggggcgcaa gtgtttatgg tcggcaaagt 3132241 tggagacgat cattatggaa cagctatttt gaataatctc aaagctaacg gcgttcgcac 3132301 tgattatatg gaaccggtta cacatacgga aagcggaacc gctcatattg tgcttgctga 3132361 aggcgacaac agcattgtcg ttgtcaaagg cgcgaacgat gacatcaccc cagcgtatgc 3132421 gttaaacgcg ctcgaacaga ttgaaaaggt cgatatggtg ctgattcagc aggaaatccc 3132481 agaagaaacg gttgatgagg tgtgcaaata ctgccattct cacgatatcc cgatcatact 3132541 aaacccagca ccggcccgcc cgctcaagca ggaaacaatt gatcacgcta cctatctgac 3132601 gccgaatgaa cacgaggctt cgattttatt ccctgagctt accatttccg aagctctggc 3132661 gctttatccg gcaaagctct ttattacgga aggaaaacaa ggcgtccgct attcggctgg 3132721 cagcaaagag gtgctcatcc cgtccttccc tgtagaaccc gttgatacaa ccggagccgg 3132781 tgatacgttt aacgcagcat ttgccgtggc cctggctgag ggaaaagaca ttgaagccgc 3132841 attgcggttt gccaatcgtg ccgcttccct ttctgtctgc tccttcggtg cccaaggcgg 3132901 aatgccgaca agaaatgaag tagaggagct gctgtcatga aaaaacacgg tatactgaac 3132961 agccatcttg ccaagatttt agccgacctt ggccacactg ataaaattgt catcgcggat 3133021 gccggactgc cggttcctga cggcgttttg aaaattgatc tttcactgaa gccgggcctt 3133081 ccggctttcc aagatacagc ggcagtactg gctgaggaaa tggcggtcga aaaagtcatt 3133141 gctgcagctg aaataaaagc atccaatcag gagaatgcga aatttctaga aaatcttttc 3133201 tctgaacaag agattgaata cctttctcac gaggagttta agctgctgac aaaagatgca 3133261 aaggcagtca taagaacagg agaattcaca ccatatgcca actgcatcct gcaggcaggt 3133321 gtacttttct agaaaggaag atgaaacatg cagattgaaa tgaaagacat tcataaaaca 3133381 ttcggaaaaa atcaggtgct gtcaggcgtt tcctttcagc tcatgcctgg cgaggttcac 3133441 gcattaatgg gagaaaacgg cgccggcaag tccacgctta tgaacatttt gacaggcctg 3133501 cacaaagcag ataaaggtca aatcagcata aacggaaacg aaacgtattt ttccaatccg 3133561 aaagaagcgg aacagcatgg aatagccttt atccatcagg aattgaatat ctggccggaa 3133621 atgaccgttc ttgagaatct atttatcggt aaagagatat cctccaagct gggcgtttta 3133681 caaacaagaa aaatgaaagc gctagcaaaa gagcaatttg acaaactttc cgtctctctt 3133741 tctcttgatc aagaagccgg cgaatgttcc gtcggacagc agcaaatgat cgaaattgca 3133801 aaagcgctta tgacaaatgc cgaggtaatc attatggatg aaccgaccgc agcgttgact 3133861 gaacgtgaaa tcagcaagct ctttgaggtc attacagcgt taaaaaagaa cggcgtctcc 3133921 attgtctata tttcgcatcg catggaagaa atttttgcga tttgcgacag aattaccatc 3133981 atgcgtgacg gaaaaacggt agatacaaca aacatctcag aaactgattt tgatgaagtc 3134041 gtcaaaaaaa tggtcggacg ggagctgact gaacgatatc caaaacgcac tccttctctc 3134101 ggtgacaaag tattcgaggt gaaaaatgct tccgtaaaag ggagttttga ggacgtcagc 3134161 ttttatgtgc gttccggtga gatcgtcggt gtttcaggat taatgggagc cggccggaca 3134221 gaaatgatga gagcgctgtt cggcgttgac aggctggaca cgggtgagat atggatcgct 3134281 gggaaaaaaa cggctattaa gaacccgcag gaagccgtga aaaaaggtct cggctttatt 3134341 acagagaatc gcaaggatga agggctcctg ctcgacacct cgatccgcga aaatattgcc 3134401 ctgcccaatc tgtccagctt ctcaccaaag ggtctcattg atcataagcg ggaggctgaa 3134461 tttgtcgatc tgttaatcaa gcgcctcact atcaaaacag catcaccgga aacgcacgca 3134521 cgccatttat caggaggaaa ccagcaaaaa gtggtgatag ccaagtggat cggcatcgga 3134581 ccgaaagtgc ttatcttgga tgagccaacc agaggtgtgg atgttggcgc caaacgagag 3134641 atttatacgc tgatgaatga gctgaccgaa cgcggtgtcg ctatcatcat ggtgtcatca 3134701 gagcttcctg aaattctggg aatgagcgat cggattatcg ttgtccatga aggcagaatc 3134761 agcggcgaaa tccatgcgcg agaagcaaca caagaacgaa ttatgacact tgccacggga 3134821 gggcggtaat atgaaaacgg aacaactgca aacagaacaa aaacggattc acttcgacgg 3134881 agtcatgcaa aaactcggcc cgtttcttgg tttatttatt ctcgttatca ttgtatctat 3134941 tttaaatccc agctttcttg aaccgctgaa tattttaaac ctgcttcgcc aggtcgccat 3135001 taacggatta atcgcgttcg ggatgacctt tgttattttg acaggcggca ttgatctttc 3135061 tgttggcgct attcttgccc tgtccagtgc tttagttgcg gggatgattg tgtccggtgt 3135121 cgatccggtt ctcgcgatca tccttggctg tatcattggt gccgtactag gcatgatcaa 3135181 cggattattg attactaaag gaaaaatggc gccctttatc gccacgcttg cgaccatgac 3135241 tgtgtttcgc ggactgacgc tagtgtatac agatggaaat ccgattaccg gacttggcac 3135301 aaactacggt tttcagatgt tcggacgcgg ttacttttta ggcattcctg taccggcaat 3135361 tacgatggtt cttgcctttg tcatcctttg ggtgcttctt cataaaacac cattcggacg 3135421 ccgaacgtac gctatcggcg gcaacgaaaa agccgcgctc atttcaggca tcaaagtgac 3135481 gcgcgtgaaa gtgatgatct attctttagc cgggctttta tccgctcttg caggtgccat 3135541 attgacttcc cgcctgcatt cggcccagcc gactgcggga gaatcgtacg aacttgatgc 3135601 tatcgcggca gtcgtcttag gagggacaag tctttccggc ggccgaggac gcattgtcgg 3135661 cacgttaatc ggggtgctga tcatcggcac acttaataac ggacttaatc tgcttggcgt 3135721 ctcatcattt tatcagctgg ttgtcaaagg gattgttatc ttaattgcgg tattgttaga 3135781 ccgcaagaag tcagcttagg agggttttac atgaaaaagg ctgtatccgt cattttaacg 3135841 ttatcattat ttttgttaac cgcctgttcg cttgagcctc cccaatgggc aaagccatca 3135901 aactcgggga acaaaaagga attcaccatt ggcttgtccg tctcaacgct taataatcct 3135961 ttttttgtct cattaaaaaa gggtatcgaa aaagaagcta aaaaacgggg aatgaaagtc 3136021 atcattgttg atgcacaaaa tgattcatcg aaacagacga gtgacgtgga agatttaatt 3136081 cagcaaggtg ttgatgcatt attaatcaac ccgactgatt cttcggcgat ctcaacggca 3136141 gtagaatctg caaacgcagt cggtgtgccc gtcgtaacaa tcgatcgatc tgcggaacaa 3136201 ggaaaagttg aaaccctcgt tgcttccgat aatgtaaaag gcggtgaaat ggccgcggcg 3136261 tttattgccg acaaacttgg aaaaggagca aaggtggcag agcttgaagg cgtccccggc 3136321 gcatctgcca cacgggaacg cggctcagga ttccataaca tcgcagacca aaagctccaa 3136381 gttgtcacaa aacaatcagc tgactttgac cgcacgaaag gcctgactgt catggaaaac 3136441 ctgctgcagg gacatcctga tatccaagct gtttttgctc acaacgatga aatggcgctc 3136501 ggtgctctcg aggcaattaa cagctcgggg aaagacatat tggtgatcgg ttttgacggc 3136561 aataaagatg cgctcgcttc cattaaagac agaaagctgt cagccaccgt cgctcagcag 3136621 cctgaattaa tcggtaaatt ggctacagaa gcagcagatg atattttgca cgggaaaaaa 3136681 gtgcaaaaaa caatatccgc gcctctcaaa ctagaaacac aaaaataatt gtctgatgtt 3136741 taggaacctg cgataacgtg aatagagata tagaatgaat tatttctctt acgtgaggag 3136801 aggaacggca tgaacaaacc aacaaaacta ttttcaacat tagcacttgc ggctggaatg 3136861 actgcggcgg ctgctggcgg cgctggcacg atccatgctc aacagccaga aacaacggta 3136921 agcattgatg atttatacag ttatccgatt gattcttatt tggtatcagc agaggctcta 3136981 aatgtcagaa cgaagccttc cgcatcaagc cagaaagccg atacgctgca cttaggagat 3137041 agcctaaagc tgatttcctt ctcaaatgct gactgggcaa aggttaagta taaaaatgga 3137101 aaaacaggat ttgtatccac tcattacatt gttaaagcag cgacaacggt aaaaaccaaa 3137161 acaaaaacaa aagtgtatac atccgctgac ggaaagagca ttaagactct tccagcagac 3137221 acaagcgttt cttttttagg ctggagtaaa acgaataaag gcggttttga ttttgattgg 3137281 gtattcgttg attacggcgg tacgacaggt tatatgaaaa caaaggattt acacatgaca 3137341 aaataactga gagggattcc gcataaatgc ggaatccctt ttattatgaa ttgatttgtc 3137401 acattcccaa gatatttctc aggaaatatt gtcgtatgct gtgtcgaaac cttacatgat 3137461 catcgacatt tttgttcacg ctaaaaagcg gaggtgtaaa tatggatcaa tttgaagcag 3137521 catatgaatc gtataaagcc cggcaaacaa ctgccgatca agaaaatgtt ccatctggaa 3137581 aagaagaaat tattgcggtt agaagaaatg aggaagacaa tattatcgca gtgaaaacca 3137641 atacaggaag agagctcgac taccctactg cgctgtcaga agcaaaatca ggaaaactcg 3137701 ctcatgttga tgtcttccat aaatacgggc gtgacatttt gcgaagtgaa ccggacggca 3137761 tcaaggaaaa taacctgtct gagctgccgg atttttaaac aaatacagcc ctgccgtatg 3137821 ttggacaggg ctgtatttta aacaaaaggc tgctggatgt attcggctaa ccgttttgca 3137881 ctgtgagaaa tatcctctgc agctgcataa ttcacgccat agaacacata tggaggcaga 3137941 tacttcatgc cgatcagatt actcgtggcc tgaaatggtt tcaatagctc actgatcgag 3138001 taatgatttg ctccgcccgc ttgatatttt tccgcttcgc tccctgttga tacagccagc 3138061 atcagctcct tgccatgcaa ggcatttcct tctgaaccaa aagcccagcc ataagtcagc 3138121 acaagatcct gccatttttt caagagcggc ggagagctgt accaatatag cgggaattga 3138181 aagacaatcc gatcgtattc ctcgcacagc tgctgttcct tcgcaacatc tatcgcttca 3138241 tccgggtatt ccttataaag atcccgtact gtgatattgt catgtttact caattcctca 3138301 gcccacgcct tattaacaac tgaggtctcc atatgaggat gcactgccaa aaccaatatt 3138361 ttcatcagac cacaccttta ctgttttgat gttattttat ctaaaatcag gaaaagagcc 3138421 aaataaaaag aaagccctgc taaaaggggc tttctttttt tcttttattc agggcttcct 3138481 tcagttgttt cgatatcttt cgcaaaatca gggttatcca gattcgcatt aaagaaatcc 3138541 gctgtgttcg gaagtctgag attcatgttc attttttgag aaatcgtaac cgtgcaatcc 3138601 tcaagcacat agtcaaaaac gtgtccgcct gaattgcgtc cttcgtcaat gaagtgcagg 3138661 tgatagccag aaacggcgat tccgtttgca taagctggtg tcaagaaacc tacaatcgtt 3138721 cctctcacgt tgtcgaagtt gaaaatcggc tgtgttttga ccgcttcaac cattggcacg 3138781 taaggttttt cttgaagttc tactgttctt gtctgcacct ttttaaacaa tccgtcaatg 3138841 cgaattgcat aaaataagtt tctgcttggc agcatgctgt tgatctcttt ttcaaagtct 3138901 tcgcgtgtca ttttcgcatc aattttgtgc gtcatgtccg gtgtaaagaa cgtaaatgaa 3138961 cagaacggtg aacggtctcc attttggacc ggtgtcgcgg ttccgtctga gcgaagacgg 3139021 taaaattcgc cgtcaaaccc aatcagctct ccgtcaagct tgttaaaggt tccgataccg 3139081 aagtctccat atttcggaat ctctgacagt tcaaaatctc cgtcatatac tccgtctaat 3139141 agagaagtca ttgttgatac ttgataaatc tggctcacag gctgatcttt ttgaccacgg 3139201 ctgagcactt gaatgttgct ttctcgtttc atatttccct tcactccttt tatttagtgc 3139261 tgttcataaa acagtgtcgt gatgcgcaga gtgctagaga gctttcgttt tcatgagttc 3139321 cccgaattct ttcggaagct tgtcacttgc taaattaatg ttatcactgt agtcaaccgg 3139381 gacatcgatg atgacaggac cttcagcgtt catgccttga cgcagaacat ctgccagctg 3139441 gtctggtgat tctacgcgca agccagttgc tccgaagctt tccgcatatt tcacgatatc 3139501 gatatttccg aaatcgaccg cagatgtacg gttatatttt ttcaattgct ggaatgcaac 3139561 catgtcatat gtgctgtcgt tccatacaat gtgtacaatt ggtgctttta gtcgaactgc 3139621 tgtctctaat tccattgctg agaataagaa accgccgtca ccagagacag aaaccacttt 3139681 ttctcccggt ttcaccaatg aagcgccgat tgcccaagga agcgcaacgc cgagtgtttg 3139741 cataccgtta ctgatcatta atgttaacgg ctcgtagctg cggaaataac gtgacatcca 3139801 aatggcgtgc gaaccgatat cgcaagttac tgtaacatga tcatcgactg cattacgcaa 3139861 ctctttaacg atttcaagag ggtgcgctct gtctgatttc caatctgcag gcacctgctc 3139921 accttcatgc atatattgtt ttaaatcaga aaggattttc tgctcacgct ctgcaaattc 3139981 cactttcaca gcatcgtgtt cgatatgatt gatcgtggac ggaatgtcac cgatcaattc 3140041 aagatcaggc tggtaagcat gatcaatgtc agcgataatc tcgtctaaat ggataattgt 3140101 ccggtctcca ttgatattcc agaatttcgg atcatattca atcgggtcat agccgatcgt 3140161 cagaacaaca tctgcctgct ctagcagtaa atcgccaggc tggttgcgga acaaaccgat 3140221 acggccaaaa tattgatcct ctaaatctct agaaagggta ccggcagctt gatatgtttc 3140281 aacaaatgga agctgaacct ttttcaaaag cttgcgaacc gctttaattg cttccggtct 3140341 tccgcctttc atgccgacca aaacgacagg aagttttgct gtttggattt ttgctatggc 3140401 cgcactgatt gcatcatctg ctgcaggacc gagttttggc gctgcaacag cacgcacgtt 3140461 tttcgtattt gtgacttcat tcacaacatc ttgcggaaag ctcacaaaag cggccccagc 3140521 ctgccctgct gacgctatcc taaatgcatt tgtaacagct tccggtatat tttttacatc 3140581 ttgaacttct acactgtatt ttgtaatcgg ctggaatagc gccgcattat ccaaagattg 3140641 atgtgtccgt tttaaacgat ctgcacggat cacgtttcca gcaagcgcaa cgacagggtc 3140701 tccttcagtg ttcgctgtca gcaggcctgt tgccaagtta gaggcacccg gtcctgatgt 3140761 gactaacacg actcccggtt ttccagttaa acggccgact gcttgggcca tgaatgctgc 3140821 gttttgttcg tgccgggcaa cgataatttc aggtccttta tcttgtaaag cgtcaaatac 3140881 cgcatcaatt tttgcacctg gaatgccaaa tacatgtgtg acaccttgct ccactaagca 3140941 atcaacaaca agctccgccc ctctgttttt cacaagggat ttttgttctt ttgttgcttt 3141001 tgtcaacacc ctcactcctt attatgcatt ttaaacgtaa aattttaaat atcttgtgat 3141061 aagtttcact atacactctt tggaaattga cctccaatat cgattcgcct tatgattaat 3141121 atgtaatacg aattattaac ctatggaaag gaatgcatat tgaatggagc ttcgccatct 3141181 tcaatacttt atcgcagtag ccgaagagct tcatttcgga aaggctgccc ggcggctgaa 3141241 catgacgcag cctcctctca gccagcagat caaacagctg gaggaagaag tcggagttac 3141301 gcttctgaaa aggacaaaac gatttgtcga gcttaccgca gcaggagaaa tctttttaaa 3141361 tcattgccgc atggcattga tgcaaatcgg acaaggaatt gaactggcac agcggacggc 3141421 ccgcggcgag caaggccttc tcgtaatcgg ttttgtcgga tcagctacat atgaatttct 3141481 gccgccgatt gtccgggaat atcgtaaaaa attcccatct gtgaaaatag aactgcgtga 3141541 aatatcctcg tctaggcagc aggaggagct actaaagggc aacattgata ttggtatact 3141601 tcatcctccc ttacagcata cagctttaca tatcgaaacc gcccaaagca gcccttgtgt 3141661 tttagctttg cctaagcaac acccattgac ttctaaggaa tcaattacga ttgaggattt 3141721 aagagatgaa ccaattatta ctgttgctaa agaagcatgg cctactctat acatggattt 3141781 tattcagttc tgtgaacaag cgggcttcag acccaacatt gtccaggaag ccacagaata 3141841 tcaaatggtg attggtttag tcagtgccgg aattggtatg acatttgttc cttcctcggc 3141901 caaaaaatta tttaatttgg atgttactta tcgaaaaatg gaccaaatac agcttaatgc 3141961 agaatgggtt atcgcttacc gcaaagacaa tcataatccg cttataaagc attttattca 3142021 tatttcaaat tgtcagcaga caagaactaa agagagtgat gcaggtacat gaacaatact 3142081 tgcaatctct tttttctttt gggattctta tggaattttt attaatttaa tataatcgct 3142141 tagtacaact ttatatcagt atacgtatac atacagtaca aatagttggc aaggacatca 3142201 gtaagcgcag gacattagtt tgattttaaa aatgaaagat agagaggtga agtaaattat 3142261 tgagttcacc ggcatattca cattgctcgc ttttttcgta acaatgattt ttattttctg 3142321 gagaccaaaa ggactaaatg aagctatccc cgccacattt ggcgctttaa tggttttatt 3142381 gtgcggaagt gtgtcattgg cagacttagg ggaaatcgga acaaaagtca cgggtgcatc 3142441 ggttacaatc cttgccacta tgattatggc cattgcacta gaaagctttg gtttctttta 3142501 ttgggtggct gcaaaactgc tccaacaatc caagggttca ggcatcaagc ttttttggct 3142561 aaccaatttg ctctgctttc tcatgaccat tttccttaat aatgatggga gcattttgat 3142621 cacaactcca atccttttgc ttgtactaaa atatttaggt ttaaaaaaac atcaaaaagc 3142681 cccatattta ttaagcggtg ttttaatagc cacagcctct agcgcaccga ttggcgtaag 3142741 taatattgtt aatttaattt ctctcaaaat cattggaatg gatctatatc ttcacaccgc 3142801 catgatgttt gtccctagta tgatgggact catttttatg acttgtctac tgtttatgtt 3142861 cttttataaa cgtcttccca aaagcctgcc agatataccg ggccattttc agtctctgcg 3142921 gcatagaagg taccatcctc ttcattcgcc atcagctcct ttaccagaac gaaatcaaac 3142981 aaaaatcatg ttgtttgtgc ttgcatttgt ttttctcgtc agaatgagtc tatttgcagc 3143041 atcatatacc ggtatttctg ttcctctagt cgctgtcatc ggatctttta tcctgttgag 3143101 ctggagatgg atttatttca aaacctcccc aagagacttg ttatataaat cgccttggca 3143161 catttttata ttcgctttta ctatgtatgt cttaatttat ggtctgcata atattggatt 3143221 cacagagtta cttgtgagtt attttgaacc tgtggtttct ggaagcctcg cccatgcaac 3143281 tttcgcatca ggtatctcta cttcagtttt ttctaatctc tttaacaacc atccagcgtt 3143341 aatgatcagt acttttacct taactgaaat gaccctgaat ccttcaacaa caaaaatcat 3143401 ctacttggca aatattatcg gcagtgatat cggttcatta ttattaccta tgggaacctt 3143461 agcaacgctt atttggatgc atatattaaa acagcatgat gaaagtattt catggggcga 3143521 atatataaaa acgaccatta tcatcattcc gctgactgtt ctttttacgt taacatgttt 3143581 atatttttgg atcagttggt tatttcttta gcacagtatg aaacgaaaaa ctgccttctg 3143641 cttttcaaga gggcagtttt gtatacacta gggaagatgc attgtcttta gatgatttaa 3143701 cttccaaatg actggctctc cacttgcgtt aataagctca atgatattat tagagacacc 3143761 ctttaatagt ccgacttttt ctggcacctc tcccatatca aatatgacca attcaccaat 3143821 attttttttg atctgctcct caaaattacg cacaagagga actttggaag gcacgaccgg 3143881 caattgtgag ttgtcaagag tatacggtgt ttgttcagtt gaataagggg taaaccattt 3143941 taaatgatgc atagatataa aaagtatttt aaatacgggt gagaaaaata caatataatc 3144001 gtttaaaaca tttgtaacat atccatggat cgatcgaccc ccagttacat aaacttcaat 3144061 aaactggcct ttgaccttgt ttaatgtatt tctatatgaa aaagcttgag tttctgcctc 3144121 tatcattgga tcttccggat tgatcaaaaa tggcttctca gtactggtca ctattttcgc 3144181 cttgtttatt tgatgaagat gcaacaaggg aatataaaga taattgcagc catcaaaaat 3144241 aacaaaaata tcctgtccga tatctatgag ggtgccgaca aaccttgtat ctcctgaaat 3144301 gacaacctca acatctgtgt taaggaattg attcaaacct ttcacgattc tcctccttta 3144361 actgaaaaag ggcatcactt tatctgatgc tcctccatta tctattaaaa tttacgtttc 3144421 cagtgatagt ctatcgttct gacaatcgtt tcatagctat aatcttcctt ttgttttcct 3144481 gaacttttta ttgaacttga atagcctggt gatcttgatg attgataatc tgaagatctt 3144541 ggtgatcgtt tagatgattt tgatgattga taatctgaag attttaatga tcgtttagat 3144601 gattttgaag aactttttga acgtgacgaa cggccagatt tggatgattg ataatccgaa 3144661 gattttagtg atcgtttaga tgattttgaa gaactttttg aacgtgacga acgaccagat 3144721 ttggatgatt gatcatctga agattttagt gatcgtttag atgattttga tgagctatat 3144781 gattttgaag aaatgaacga attgctgtcc ttatcattat tgtcttcctg gttttgttca 3144841 tttttttgat cctctttttt gtacgaccct tttggaccta agctgatgct ttttatgtga 3144901 aaaggataga tgcgaagcac ctcttgattt ttcactatag tataatggcc gtcggcatta 3144961 tctacaagga taccctcaat ggcttccgga cctccacgat taattgaaac ccatttatga 3145021 gtcagactct taaaaacctc gcttaaatca tcagcttcca aaactccaac tggcgtctgc 3145081 tcttctattt tcaaatcagg ctcgtgttta cttatacttt tgatgtgatg gatattaaaa 3145141 tacactaccc catcctcatt tgtgtttaac gcagcgtaat catctcccag ccagaccaat 3145201 cttccttttt tagattccgg acccccttgg ttaaattgaa ctgattggtt tattaaatgt 3145261 ccgattaagc tatgaaaatc atcagcatcg agcatttcct cagtctcaat tgttgtggtg 3145321 ctattattgg tatcctcagt aatacttttc acatgctcca actgataata aattattttt 3145381 ttttcagctt gtaaagctat ataatctgat tttacagctg ttaattttcc ttttttagat 3145441 tccggacctc cacgatatac agtaacaatt ttatctttca ttgagtgcaa aaagttataa 3145501 tacgatattt cattatttga atgatatttc attctcctct tgctcattca aattcctcct 3145561 agtcacttat acatagatga taaacatact gcatatatac gtgtcacatt tatttgttga 3145621 actaattcaa tagcctaatt gtcgcttttt ccgcgaatac ccattttcac gcattcataa 3145681 aatacttaaa tgatctttga ggtattgtga acggttttta atatactcgc agatcacatc 3145741 cggctcacgg tcaaaacgct caatatcatt ctttttatac gggtccatga ggacaaacgg 3145801 cctaatccgt tcatacatcg ccatgatttt cggttccata tattctattg taaaaagaga 3145861 ttggagcgtt ttttctaaca ggcgcttgta ggacttgcga aactcggatt catccaatat 3145921 ccgggcggtt agtgtattaa atccttgaat tcttacataa tcggcagcca tccgctctcc 3145981 atggatatcc ctgccccaag tcgcatcata atcccaagga atcacctcaa ataatccggt 3146041 ttccccgctt ctgtataatg cgtagttgtg gacaaacccg tcatagttcg aggtgaatac 3146101 aataccagca agccagcgca aatacttatc gacatccacg tgttttgtca cttctgactt 3146161 aaactgagct ttagggaccg tattaatttt aaaaatcata tcttgtaaat aaaaatcatc 3146221 ttcctcagtc cctgttttct tttcatatcc aagctccagc gatgttttcg tttccctttc 3146281 taaatcgctc atcagagaaa agttggcatc atcatccacc gcataaaaaa tcgcgccatc 3146341 agccagcttc cttttcgcca aataatattc atctacggat tcaagttcaa gataaacccc 3146401 ttcattcttc ccattcatct ttacaaacgc aaactctgcc tttggagaca gtgtccctag 3146461 ctccgagaaa aaatccagag acaatttgtt tctcatcaag gaagggtctt tatactccgc 3146521 atttaagtga atctctcgcg cgccgcggaa tgttttcggc tgataaaagg aaatatggta 3146581 tgacttcttt ttgaagtctc tgatatgtga tccccgataa gcgatatcaa tatccagcct 3146641 tttttgattt accttcatca cagctggcac cggatcatcg tcccatatat ccttttttaa 3146701 ttcacgcaag tcttttggat gaacaaacag ctgataaagc ggtaaattgg attgattctt 3146761 catccataat cctccttaca aattttaggc ttttattttt ataagatctc agcggaacac 3146821 ttatacactt tttaaaaccg cgcgtactat gagggtagta aggatcttca tccttaacat 3146881 atttttaaaa ggaggatttc aaattgggcc actattccca ttctgacatc gaagaagcgg 3146941 tgaaatccgc aaaaaaagaa ggtttaaagg attatttata ccaagagcct catggaaaaa 3147001 aacgcagtca taaaaagtcg caccgcactc acaaaaaatc tcgcagccat aaaaaatcat 3147061 actgctctca caaaaaatct cgcagtcaca aaaaatcatt ctgttctcac aaaaaatctc 3147121 gcagccacaa aaaatcatac tgctctcaca agaaatctcg cagccacaaa aaatcgtacc 3147181 gttctcacaa aaaatctcgc agctataaaa aatcttaccg ttcttacaaa aaatctcgta 3147241 gctataaaaa atcttgccgt tcttacaaaa aatctcgcag ctacaaaaag tcttactgtt 3147301 ctcacaagaa aaaatctcgc agctataaga agtcatgccg cacacacaaa aaatcttatc 3147361 gttcccataa gaaatactac aaaaaaccgc accaccactg cgacgactac aaaagacacg 3147421 atgattatga cagcaaaaaa gaatactgga aagacggcaa ttgctgggta gtcaaaaaga 3147481 aatacaaata atctaagttt tcattgtttc aataggctgc cggcggaggt acggaagcct 3147541 atttttttat ttgccctgta ttagatatat gtcatgacat aacatatgca acccgcatca 3147601 tttggtttcc tttaaaccat ttcgttataa tcaaggtatc ctaacgataa aggcggttgt 3147661 tgctatgtac atatttcaag ctgatcagct tagtgccaaa gacacataca agctattgtc 3147721 aggtaccgtt attccccgcc ccattgcatt tgtgacaaca ctttcttcag gaggagcggt 3147781 aaatgccgcg cctttcagtt tttataacgt cgtcagctca gatcctccgc ttctcagtat 3147841 ttctgttaac aggacggaag gacgccaaaa agatacagca cgaaacgcag tggagaacgg 3147901 agaatttgtc gttcatgtca gtgatgaagc catcattgaa gatatcaatg aaacagctgc 3147961 aagcttaagg ccggatgaaa gcgagcttac acgcacctcg cttcatcctg ttgaaagcaa 3148021 agctgtttca gttcccggca ttaaggaagc ccgcgttcgc tttgagtgca aattagagcg 3148081 gcatattacc tttgacaatg atcaaggcat cactacagca gatctgctca tcggaagagt 3148141 tgtctgcttc cacctagatg aaaaggtgta tgatgcagaa aagggatata ttttaacgga 3148201 tgaattaaag cctgcctcac gattggcggg aaatcactat gccaagctgg gggaagaatt 3148261 cacactgatt cgtcccagct gaagagaagg actatttaaa tagaagaaac tagtcaaaaa 3148321 gaccttatga ttacaaaata tcgcctgtaa ataactgaaa aaatatcaaa aaaaagaaca 3148381 cccagagcaa gctcggggtg ttcttttatg aaacgttttt cctttttctt cgtataaagg 3148441 tagattagga ggaattggaa tgacaaactt ttggatttta atgctgatcg ctattaccat 3148501 cagtctcgcc tctcaatttt ttataaagaa aaaatacggt attgataaat ccggctggcg 3148561 atataagcat gtcagcaata cacacaaatg gatcgaaatc actttactta ttttgtttgt 3148621 gttttcactc tccttttttc cagttgaata tttgcttctt ttatttttta ttgtgattga 3148681 ctcaatacgt atttttatgg agtggcatta tagacctgaa gataaacagt atatgtacca 3148741 cattgtagag gtctccctta tgtttatgct tttgatttat gtttgtaccc tatagttatt 3148801 taaatcccca cagccgctcc gtctccccga ggatcggctc cgccttggag aaagccttct 3148861 tcatcaactt tgattgcagc cgcttgtccc atcagcggat catagtcacc gacaacctcc 3148921 acgagatgcc cgctgtcttt cagtttttgg attgttttgt ctgtgaatct gccctcgact 3148981 ctgagacctt cgtattcctc tccccacgtt ctgccccata cccagcgcgg ttcgctgatt 3149041 gcctgctgtg gatgcattcc gtagtccagc attcgggtaa tgatggccgt ctgggtctgc 3149101 ggctggcctt cgccgccttg tgtgccgtac agaatttttg gctttccgcc tttacagacc 3149161 atagccggca tcaacgtatg gaaggtgcgc tttctcggtt caagcgtgtt gacatgattt 3149221 tcatccagtg agaaaaacga tccgcggttt tgcagtaata tgcctgtatc accggcagtg 3149281 actgccgagc caaattcaaa gtacaggctt tgaatgaatg acactgcgtt gccatccgca 3149341 tcgattacgg ccgcatatgc cgtatcactt cccaccggcc tgctttctgc cggtattgcg 3149401 agatagccga tttcttctgc caattgtttt gcataacgtt tgtccaaaag cctttcaagc 3149461 ggaatgtctg caaacgccgg atcagtcagg acggcatccc gatctagaaa actctttttc 3149521 aatgcctcca caagcacgtg ataatactca aatgaaccgt gttcgatttg ggtgaaatca 3149581 tagttttcca aaatgttcag tgttaataaa ccggtaaatc cctgagaatt cggcggcgcc 3149641 tgatacacac tgtatcctcg ataatcactt gatacaggcg ctgcccactc accccgatgc 3149701 gctttaaaat catcgattgt catgtaactg ccgttattct gtaaatgtga gacaatccgc 3149761 tgagcgagat ctccttcata aaatgcgctt cttccttttt cagcaatcaa gttcagactg 3149821 tctgcaagct ctttttgcac aaaccgctct cccgggacag gtgctttgcc ccttctcgtg 3149881 aagatgtcag ccgtgtaagg cgtggaagcc agcagttcaa tattcttttc tgtgtgacga 3149941 cactgatcag ctgatacagg aaacccattt tgggcataat cgcgtgcggg ctccaataca 3150001 tctgcaagag acagacgccc gtactccttc aggaccgcat cccagctatc aaccattccc 3150061 ggcacggtaa tagcactgtc aattccccgc agcggaatcg cgctttttcc cttatataca 3150121 tctctcgtta cgttttttcc tgaacggccg ctgccattgt agacttttac tgcctttgtt 3150181 tcctggtgaa aggtcagcca aaaggaatcc ccgccaagtc cggtcatatg cgggtacaca 3150241 accgcaagac aagcactcac cgcaacagcg gcgtcaaacg cgttgcctcc cttatccagt 3150301 atgcggtttc cggcttgaga agcgagataa tgcggactga cgaccatttg ctttgtaccg 3150361 atgacagatt tgttcatcac aagtcccctt ttttaagaaa ttttcttcag tatagggagc 3150421 ctgatttttc acatctactg atccggcaga aaaactgacg aactttcttc ttttcgcaaa 3150481 taataagata ttttcgcatt catttcgaaa acaaatgaaa aattattatt tctatacgta 3150541 acttttatga taaaatgatt gctaaaaggc tacgaaagca ggtggagcaa ttgagtcatg 3150601 aatatcaaat ccccaacctt gtacttgatg agactgataa acaaattctc acgattttgc 3150661 atgaagaagg cagaatttct tatacggatc ttggcaaaag agtcgatttg tcacgggtcg 3150721 ccgttcaggc ccgtatcaac caattaattg aagccggtgt tattgaaaaa ttcaccgctg 3150781 tcatcaatcc cgctaaaatc ggcatccatg tttccgtgtt tttcaatgtc gaggtagaac 3150841 cgcaattttt agaagaggtc gctcttaagc ttgaggaaga gcctgcggtc accagccttt 3150901 atcacatgac aggcccgagc aagctgcata tgcatgggat ctttaccaac gatcaagaaa 3150961 tggaagaatt cttaacaaaa cggctgtatc cattgcgagg cgtcgtcagt gttgattgcc 3151021 agatgctgat caaacgatac aaaagccgta tgggaatgaa gctgtaaagg agagaaacaa 3151081 atgaaaaacc atccttatcg ggatatgacg gccgcaatgg ttcgcaccgg catattaggg 3151141 ttcggcggcg gaccttccgt gattccgctg atccgccatg aagcggtcaa taaatataaa 3151201 tggattgacg atgatgaatt cggagaaata ttagcaatcg ctaatgcgct tcccggaccg 3151261 attgccacca aaatggctgc ttatctgggc tttaagctaa aaggcacatt aggtgcaatt 3151321 gtggcgatcc tcgcccacat tctgcctaca tgtcttgcga tggtgggctt gtttgcggct 3151381 gtaaatgtgt taagccattc agcaattgtt gcaggtatga ttggtgccgt cacgccggta 3151441 attgcggtca tgctcggaat catggcgtac gagtttggcc aaaaagcgct taaaggtttc 3151501 ggctgggtta ccggcatcct gttttttatc atcgctttta tcggcctgca aactttacag 3151561 attaatcccg gcctggtcat tatcattttc ttagcttacg gggcgtttca ttttaaactg 3151621 aaagacaaaa tcacaaataa acattcaaaa gataaaggaa tgtcagcctc atgatatcga 3151681 tctatttatt tatggcgttt tttatcgcaa acctactggg atatggcggc ggacctgcgt 3151741 ctatcccgct aatgtttgaa gaagtcgtaa acagatacag ctggctctca aacgatcaat 3151801 tctcaaatat gctcgcactt gcgaacgcat tgccgggccc gatcgccacg aaaatcgctg 3151861 cgtatgtcgg ctacagcgca ggcgggtggc ccggcttcct aattgccctg atcgcaaccg 3151921 tcgtaccgtc ggcgctcgca ttgatcgtcc tgctgcgcat catccagcgc ttccgccaat 3151981 cacctgtcat caaaggcatg acgctgtccg tccagcctgt catcgcggtc atgatgctca 3152041 ttcttacctg gcaaatcggc gcagacggca tcaaagcgat cggctgggtc caatcgatcg 3152101 tgattacggg aatttcgctc cttgccatga caaaattcaa aatgcatccg gcatttttga 3152161 ttattgcggc gtttttatat gggggccttg tgatccctta tttatagaaa aaagcacctg 3152221 gacaggtgct tttttatttt agcccagaaa tgccgtttga tatgacagct gtttcttctc 3152281 ctgcgtcact cttgatcatg tgcttgactt gcagcgtggt tcctgccatt ctcacagatt 3152341 gcttcaactg ggacgaattg gtttcaactt gtatccaaac aggaggctgg accttccaaa 3152401 ataaatagag tgcaagaatc agcaagccag caatgaccga cagcaaaaac ttcatatcgc 3152461 atcgcttctt ttcagtaagc ggctcgcagc ggacagcgcc tgatgatcac gaagaatatc 3152521 gcctggacga ttgccttctc ccagcacata gcctttaaag gacattccca taaaatgaaa 3152581 aatatgttcg aattgctgaa tcagcggcag cccttttatt tttggattgt ctccgcccac 3152641 tgctattaca tatgcctgtt tcactgacat ttgctgttta aaatcaggaa atctcggatc 3152701 tctcaacgtc tgtgaccagc gatcaataaa cagctttaat gtccctgaca tgccaaacca 3152761 ataaattggg gtggcgaata taagaatatg gcactgcaat atccgttcaa tgatagaatc 3152821 gtagtcatct tgaacaggac gaaagccgcc ttgggcgtga cgcagatctt caattggttg 3152881 aattggatat ttctgcaaat aaatgtgctc cgcatcgaat ccttgaacag ccttctccgc 3152941 aagaacatcc gtatttccgc cagaccgagt tccgccgtta ataaccgcaa ttttcatgat 3153001 gcatctgctc ctttgtttac gaatgatttt cttcatcata taatggattc atcaatcaat 3153061 acagatgatt atttcgatta atccaatcgc taaaaccgat ttagaaagga agagaacaag 3153121 tggaattgaa gcagctgatc acctttatta cggcggctga acatgtaaac ttcaccctaa 3153181 ccgccaaaat gcttaattat gcacaatcaa gcgttacctc tcagatcaaa tcacttgaag 3153241 aagaaatcgg aacgccttta tttgaacggc tcggcaagcg gcttatcttg acagaagcag 3153301 gaaaaacgtt caaatcttat gcacagaaga tcattgcgtt aacagaagaa gcgaaaatgg 3153361 ccacaaatca agtaagagaa acaaccggaa ccttaaaaat cggggcgacg gaaagccagt 3153421 gcacataccg cctgccccct atcataaaag aatttaaaca ggcttttccc caagtaaagc 3153481 tcatattcaa accatatatc tccaatgaac aagcgaaaga acagctctta cagggccagc 3153541 ttgatatcac cttcatcttg gatgtaaacc ggatggaaga cgcactgcac gttgaatctt 3153601 tgattcagga tgagatcaaa atggtggctg ctaatgacca tccttttcct gcggatttac 3153661 cagtaacatt gaaggatctt caaaacgaaa ctcttctgct gacagaggac ggctgctcgt 3153721 accgcacgct ctttgagaac aatttgcatg actccggtat ctatcctaac aaattggaat 3153781 tcgtcagcat agaagccatc aaacaatgcg tgatggccgg acttgggatt ggaatcttgc 3153841 ctgaaatgac agtaaaagat gatattgcag caggccggat gaaagaactc aattggcaga 3153901 gcgattgccc cgttttcact caattagcat ggcataagga caagtggatg tctgcgccat 3153961 taaaggcttt tatcgatttg acacggaaaa cattcaaata aaacctctcc acaaggacga 3154021 caaggttttt gagaccaggg cacacacata caaaaaaaac acttgatgac ttagagcccc 3154081 aagtgttaca cgtgattttt ctgataaaac gttcgcaaaa catgcgtctc aaggtcagcc 3154141 aggcggacag ggatcggcag cctgctttct tgattgatca agctcatcgt gatctgatag 3154201 ctgctgtcta aatcaatata attaccgcaa gacaagaaaa taggcttcac gtcccgccgc 3154261 gttcgcagcg cccgtccata tacctcgccg tcaatgataa tatcggtgta tgcgcctact 3154321 tcaatttcag gcgtcacgaa atcgcagcct ttgattttga gataggtttt cgctatccca 3154381 atcgtcggct tgcccagaaa aaaagccgca tgggtggcaa cgcccatatg attgtaatgc 3154441 agatatccgt tgccatcaaa caagaagaca tccggctccg tctccagctt tttcgccgcc 3154501 tcgatgatca agggcagctc gcgaaacgca agaaaaccgg aaacatacgg cacgctgatt 3154561 ctccccatgc tgtgcacttt ttcaatgact tcttttgtat cagcgtcaat tacgataata 3154621 cagcacactc cgtatggttc tccatcctgc tcccaatagg ccaggtcgac gcctgcgcag 3154681 gtgttgatgg agtctggatg gatcgtgggg gataggttga tacgattttt aaggttaaat 3154741 tgcacttgta aaaagtcttg ttcctttttc atatcaaatt tatgcacatc aaataccttc 3154801 ataacgattg ctcactctcg acctaaatta atgtgagtct ctcttctcga ttctagtatt 3154861 tcaaaatgag gactatctgt atctatctcg tacttattta atagattgcc ttcttcatcc 3154921 caattctttt cagaaattag tatggaatgc tcatactgtt gctcactttt tttcctgcca 3154981 ttttcaaacc aaattatgct tataccgtgc aattgcccat atcggtattc tttttcactt 3155041 tttttattcc cgttttcata aaattcacat gttaaaccat gggccagacc attcttatat 3155101 ttagtaaaat agatgatttg accatttgga tataattcgt aagccagccc tgtaaacggc 3155161 tggccatttt cgtcttcagg attatctaaa atctcatcac ttaccgaaga gaaccataaa 3155221 tcctcaaagt ccactccctt ttcttttata ctcttcatat catattcatt ttccatactt 3155281 taaagcctcc ggtatataat ttgtattttg agttatatat tcacaatgtg gacatctagg 3155341 cattgggaca ccttctggca tctttttatt tattttccta gcacttacta catataccat 3155401 taaatctttt aaatccgcat caggtctttg aagtaacgct tcatttagag cattaacttc 3155461 ggcatgagaa cccgcccctg acgtctttat ataaccttct ttaagttctg taggcatatt 3155521 tacaattcta tcatgaataa gtggatgtag taccttaggt ggcttcccat ctatattgtt 3155581 tattccaaaa taataattgc ctgttttttt gtccaataca ccagctaccg cagggcctct 3155641 ttgtttttta gttagaccag aagatttaat tctactaagt tcgtttagta cttctgccct 3155701 tagatttatt cgatggtgaa gatcttcttt agacaataca ccatgcttat ttcttaaata 3155761 ttgaagccta gtttgttttt cttcagtagt cttagcaata ttgctaataa ggctttcatt 3155821 actcacttta ttgacatatg gagcattttt ttggtacaac cgatcaaagt agtgtgccaa 3155881 tcctgctcca ccaataatag taatagcttc cagcgcccct tgcttccgct tctcctcaga 3155941 cactttgttt ccgaacatat cccggcctgt gacagcttct gagaatccgt ttgacgcaac 3156001 aaggccgtat gcgcccattt ctgtcatttt gagaatgtct aaggatttgc ctgttttgta 3156061 ggcgtctaat gcgtgttcag cagcgatagc tgcttttccg gttttgtaga tggcttttcc 3156121 gcctttgaag gcccggcctg cccagccgac gactggtatg aatccggcag cggccatagc 3156181 tcctgctgtc acacgctccg cggtggagag tttttctccg gtaaccggat caacgccttc 3156241 ggttgctctt ttataatcat aatagccagt gacttctcca gtaaagttgc aaactccatc 3156301 ccatgttttt tcgtaccacg gtttgtttgc ttcttcctcg gctttttcct ggagccgtct 3156361 tgcttctgct tgctgggttt ttgcatcgat ataggttgtt ccttgatttt ctacttcaat 3156421 gacgcttttg tagacttcat tgctgtggaa ggcttttttg tcatagtaca taggggatgc 3156481 gctcttccca ttgctggtgg cctgcatgag aacagaatat ttggtgagca ctgcgttgtc 3156541 cagagattct aaattttgat attcagtggt cagggattca tcaagcttat cgacagctgt 3156601 gattgtatca cgtctgattt tttgggcatc gcccatctta tctgcatagt cgtcaagcgt 3156661 gtacatgtcg agatcaataa tatcgctgat gcctgacaaa atagaatcga tttcttcttt 3156721 atgagcggag acaatctctg aggctttcag gtctccattg ggcagctcat gatccaaaaa 3156781 agaagtttcc acatatgaat cattcagttc ttgatcttta atatctcctg aaatgccgtt 3156841 taaaaacgca atttgagcag agacaagcgt cagccagctg tctacgattt ctgcctgtcc 3156901 ctgaaaaaaa tctttaatat tgtccgcgcc atttccttta aaattatcgc ctaaatcggc 3156961 aactccctga aacgcttttt tcagcgtatt cagctgctct tcaagcgtct catattgctt 3157021 ttttctgctc ttcgcttctt cgattaaaga ttttgattca aatactttac tcatcgcact 3157081 gccctttctg ttctatttta ccgctatcgc ctcgtcctgc tctttgagtg aatctacgtt 3157141 atcctttgta tcctcgatat ttttctgtac cgcttttttg taatctccga gcatggtttt 3157201 gatgttctcc tcacgctcat ggtatttttt cgtataatcg aggctgtttt ttccgttgga 3157261 tcctgcggcg ccgattgata cgtcagcaag cgcatctttg acagaatcta atgttttgat 3157321 gactgtgtcg tacttcagct taatttctga cataaaaaaa gatcaccacc attttagttt 3157381 actaattgta tttccgactt cttccgcgaa ctcttctccc tttttaagaa gatctgctgc 3157441 accatttgct atgaacaatt ccgatgcata tttagcttta tcccattcaa gatcaaaaat 3157501 tttcccgtta atcgaagcca tatactcgtt atatttatca ttcacaatct tagatgcttc 3157561 cgatttcgcc tcttctcttc ccttgtcgaa atcatcggct tttgttcccg tccaatgctt 3157621 gcccaattcc ggtttcacaa tttctttgat ttcagtgatt gcctcttctt gcagtgtgtc 3157681 tatgtccttt tttgcttttt tcagcttttc gatcttgtct tccacgtctg aaatttttcc 3157741 gttgagcgaa cttttgatat ccgctagcat actttcataa cccatctgaa tcacctctta 3157801 atactcaaaa agtcgtatgg aggggctgat gaagatagac ttttccatac tttatttcca 3157861 tatattatat tttaaaatag ccagaaggcg gcttaaatag ggtaaatggc ttaatttagg 3157921 catataacgc tcttgaaatg taggtatttg atcttgtttt tgttcgttat acagctaata 3157981 aaagcgtttt ataaaatgaa atcacctaat gtcatagtta taaaggcact tgaaagaggc 3158041 agatgttgtt gatctgcctc tttcggcgct gagcttattg ttcatgttta tgttcttcat 3158101 ctggtcggcc atgtctgatt ttgtcatttg gcttctatta ttcccccctt ctgacccttt 3158161 ggatcaaaag cttgtattag ctgcagtccc agttgtacag aacgtttgaa aagtcttttt 3158221 tccttagatc ttcaggtgtg atgaaaaaat tggcgatgcc gacgtctccc cacattgaat 3158281 cgatatcatc gtctgaatca atttgtaaca gcatgatggt gtgttcttta tatgcgtatt 3158341 cccggggatc atgctgggta aaagaagcgt atccgccaat tttatggcca aatccgtttt 3158401 cagccagttc attataaatg tcttcttcat cctcgccgaa ctgaccaaag aactccattg 3158461 tttccatgcc cgtatactgc tcaaattgaa aatctgtagg cagcacccat tccgaagatt 3158521 tcacaggctc gactgccgct tctgataaaa tcggaaaatc acattcgcct gtgccaataa 3158581 atgaaaaatc agaaacaagc tcgtcatcgt tttctacgat attttcaaaa tagatcactc 3158641 tgaaattctt ttgttcacat cgatcgtcaa aattcaatcc atagacgtca tcatgaacag 3158701 aaatgtagaa ctgcaggata cctgaagaag ggtagccgtc aagctgggga atgtgcgaga 3158761 aattaatctg cgccagaagt ttcatcggct gtccattttc gtcagtcgga tatgtttcat 3158821 gcttggggaa atagggatca ccggcaattt tgctgtcata tcgtcctgtt ttcccctttc 3158881 tcacattcag tttcacgtat tctttcgctg atttctccag caagtcgcgg tacggtctca 3158941 ttttttcggg cagatgattc atcagattct ctccttttcc ggcatctcca aggttttatt 3159001 ttctggtttt cttctaatgt ttttcaaacg aatgtttaaa gaagccctac ttctgcataa 3159061 ttttccaaac aatagttaaa tagtagcaaa tgtattcagc accccgcaat agatgaaaaa 3159121 aagactggtg cgcaaccagc ctttcttttt catctattga attgcacctg acggaacaac 3159181 cgccttccgt ccgacagaat aatactccac tcctgcagcc aaagcctcat ccaatgtgta 3159241 gcagtttctg ccgtcaaata tgagcggcgt ttccatcaaa tcctgataag ccgctaacgg 3159301 gaattgttta atgtcagccc agtcggttaa aatcatgacg gcgtcagacc ctttgacagc 3159361 ttcctcgatc gtctctttat attcaacagc ttgcgggaga acatgctttg catggctaac 3159421 tgcaatggga tcgtaggctc tgatacgggc gtcgagcgca gcgagacggt ctgcaataac 3159481 aattgacggc gcttctctca tatcgtcggt attcggttta aatgacaggc ctaaaagggc 3159541 aatcgttttt cccgtcaccc caccgagcct gttcagcgct ttatcaacca gcatcgcctg 3159601 ctgattgttg ttgactttga taacggattt cagcagttca aaatcatgct cgacattgcc 3159661 ggcaatttgc acgagggcgt ttgtgtcctt tggaaaacaa gagccgccgt agcctatgcc 3159721 cgcttttaaa aactggctcc cgatccgctt atcctgtccc atcccgtatg cgactgcttc 3159781 aatatcggcg ccgacctttt cacatatatt cgaaatttcg tttataaaac tgatcttagt 3159841 ggccagaaaa gcatttgagg catatttgat catctcggcg cttctgatat ccgtttggta 3159901 aatcgggatt tgaaacggac ggaagagctc ctccagcgta tttgctgttt tctcatcggc 3159961 cgtcccgatc acgatcctgt caccatgaaa ggtatcatag atcgccgacc cctcacgcaa 3160021 aaattccgga ttggatgcga ccgaaatact gacaggctcc gctagatgtt cagtaatcag 3160081 tccattaatc aaatcgtttg tcccaacggg cactgtgctt ttcgttacca cgactgtatc 3160141 tcgtttgaca tgctttgcga tgcgtttggc cgcatctgta atttgctcca gattggcgtg 3160201 cccgtcgctt ttctgcggtg tgccgaccgc tataaaaatg atgtctgcct gtgccaagcc 3160261 tttctcatag ctcgtttcaa agttcagccg tccatcagct gtattttttc tcatcagctc 3160321 ttcaagacct ggttcaaata tgggggaaat gccctttctc atttcatcaa tcttgtgagc 3160381 gtcaatatca atgcaggtta catgatgtcc aatctcagaa agagaaacac ctgtcacaag 3160441 accgacatag cctgttccga tgactgttat attcattgtt tccctccaac agttaaattg 3160501 ctgctttgca gcttccgtaa tatcgtatga gaacatccta tcatgaatgc gaatgatctc 3160561 ccgcatagcc tgtcgggtac agcctgtaca gatttctgaa atgtgattca accatacaat 3160621 acactattat atcgctctca aaaagaaagt ggtgaaatga gaatcggctg ttaaaaaaaa 3160681 ccaaacaatt ttcttctttt gaccggctgc ggaggctgtc tgaagatggt ctgattccgc 3160741 aggagaagct ctgcattttc cgtcagcata taaggaagtt ccgagccgaa ttctttctct 3160801 agaacataaa gagcctcttg agtgtgaaaa tttctcgttt tcacattatg ggcatctgag 3160861 gctacgaaat ggatcaaatt ggcttcaacc agccggagag aaaatgcttt cagctgcttg 3160921 ccgaagatcc ccgcaagact tcctgaagta atctgagatg ctgctccttt ttccacaaga 3160981 tgatacagca aggacgggtt ttcgcgaatt tccctgttgc gttcaggatg ggcgataacc 3161041 ggaatatatc ctttcagctg caaatcataa aaaagctgct ccgcatatcg gggaacgtga 3161101 tcaaacggaa actcaatcaa gatgtatttt gtatcattca gcgaaagcag ctgacgtttg 3161161 gcaaggtctt gttccacctc gccgtagatt ctgatttcct gtcccggaag cacatgtaaa 3161221 ggaatgtctt ctttgattaa acgtttgttt aactgatctg ctgcttctct gactgcggct 3161281 ggctcgtttt tatacacacc gttgttatga tgaggtgtcg caatgatcgt ccggattccc 3161341 tgacgaacag ctgctcttgc catttctatg ctgtcggccg aatcacctgc cccgtcatcc 3161401 attgcgggaa gaatgtgaca gtgaatatcg atcatgtcct agcccccttt tttcgcaaaa 3161461 ataaataacg ggcacgatgc acgttattta tttttgcatg aaattgtcct tggttccgta 3161521 atatccgtat tcagagtgct tcgaaagctt tttgccgttc ataatcgccc caaggagctt 3161581 gcttttgcac gttgcaagcg cctctttcgc ttttgcggct tgttcttttt ctgttttccc 3161641 gcttgaaata accagaacag aaccgtctgc cacgttgcct aaaatctgtg catctgctac 3161701 ggcaagaata ggcggcgtat caaaaatgac catatcatat gccgcacacg cttcgtatgc 3161761 aagctccttc atccacttcg aggagagaag ctcggccggg tttggcggga tcgggccgct 3161821 cgtcagcacg tcaagatgtt tttcattcga tgcttgtaca gcctgctcca tagagctttt 3161881 ctttaataaa acagatgtta agccaaccgt attttcaaga aaaaaagccg tatgtactgt 3161941 tggttttcgc aaatcagcat caatcaggag cacttttttt ccctgttggg cgaatacgac 3162001 agccaggttg gcggccgttg ttgattttcc ttcccccgga caagccgatg taatcatgac 3162061 tgatttcatt tgccggtcca ctgaagcaaa ttctatattc gtgcgaatcg tccgatattg 3162121 ttcagagttc aaggatttcg gctctgtcat tgcaatgaca tttctctgca tccgcgagcc 3162181 tctgtttttt ctaagcgcca aaatgtccac tccccgtttt ttcagattgg aaaccctgta 3162241 aggtctttgc tgttttctgc tcattcgcaa tggtggaaac tgtccctaaa acaggtatgt 3162301 ccagcaagga ttcgagctgc tcttccgatt tgatcgtatt atccaaatgc tcaagcagga 3162361 aggccagtcc gatgcttccc gccaatccgg ccgcaaacgc gatggcaatg tttagtagcg 3162421 gctttggcga tacaggggac gggtgttctg aaacctcggc ttttgacaga atgctgacat 3162481 tgtcaacatt cataatggat gtgattttgt cttgaaaaac agatgctata gtattggcaa 3162541 tatgagccgc tgtttccgcg ttttcatccc tgactgatat gttgaccact tgggagtcct 3162601 gttcgctgga tacggtaatt ttgtcattca gttcttggga tgtcatcgac aggcccattt 3162661 ctttaatgac ttcatctaag atggcagggc tcttaatgat gacattgtac gtattgatta 3162721 actgaagatt ggtttggaca tcgttaaatt ggacttcttt tcgttcattt ttcgattggt 3162781 tgaccagaat ctgagttgaa ttttcataga tgggtgtaag tgcgaagaaa ctaatgagtc 3162841 cgccggcagc agtggcagcc gcggttacaa tcataatcaa aagtatgcgt tttgttaacg 3162901 ttgataatat ctcttttaag cttgtagatt ctcccatgat acctccaaat ctcttataac 3162961 atccttttcc atctacgatt atacaacgtt gaaaccgcat ttctccagct tttcacgtga 3163021 cataattcga cattttttta caatgcgtta tgttagtact ttttatgtaa gcgctatatt 3163081 tactgtgttg acagtgctgt ctcattttct cttattcggg cagtcacgtt ctctcgcata 3163141 aaaaaatccc gctaaaggcg tgcgggattt ttatgttgca tatccatttt taatatgaga 3163201 aatcaaattt tcaagcattt ccttcgtcgt catctcagat gactgctcac caatttcatg 3163261 tgcatgcatc aaaattttca gaaattcttc ttgattcaat ttcttttcac tcatcttttt 3163321 tttcctttca gcttccatta agttgaaaac acgattatta tatgatgctg gttatcaatt 3163381 tgcaatctct aatacatcat tcgacacatc ctatttttta tgtccttttt taggaaaaac 3163441 tttttaaggc cgatgtgttg cgatataata gagaaattgg atctttttat tacgtgactc 3163501 ggttaggagc gataatcatg cttcagaata tgatttccaa agacgatgtg ctggcatctg 3163561 ctgaacagtt aaaagaactt cttccttaca atgaggaaaa tgttcagctg atcaaaaaag 3163621 cccttatttt atatcggcag gattcagtct atcgtttaca agcagtgagt ccgacggaag 3163681 ttacggctta cgtgcaggat gttgtgcctg tgcgggtcac attgaacttg tttgtcatag 3163741 tcaaaagcgg ctgttcatgt ccgtccggaa gaatctgccg ccatatgctg gctgtgtttt 3163801 tatatgtata tgcaatgttc gagcgagtgg gtacttttac agagtattgg ctggagaggg 3163861 aaaagcttga ggaaagcaaa gagctcgtcc gccgccagtt tcaggaaaag gtgctgccta 3163921 atgaagaatc actttcaagc tggcttgctt tttttgattc agagttttct ctctggcagg 3163981 cacgtacgcc agaaggcagc caaaacatgc agggcctcta ttacggctac ctgtccgcat 3164041 taaaaaaaca tgcgccgaac aagccggagc tgaaaagcct gtatcagatt cattccgcga 3164101 ttgcggtttg gcttcgcatg ttcacattga ttgaagcggg caagctaaac cccgaacaag 3164161 atttttattc cctcaatccg tacgttgaac agctgatgga tacaatctac agctctattg 3164221 ataaattaaa aacgtacgcg ctgtcttttg cgcttgatcc gtttttggat aaaacaccgg 3164281 atgttatccg gcatttgctg ttgaaagaag aaattttcca atatgaacgc atccgcgtct 3164341 tcggtgaaat ttggagtgcg ctgctgtcgc ggccaaaatg ggtggcacgc gaacaggaga 3164401 tattgaaaaa agaagcagga cggcgttttt ctcccgaatt gcaattcggg cgcctgcatt 3164461 tggaattcct gcaaaaaaat gatgacgtta tttttgagga agcggatcaa ttcccgccgg 3164521 aagcgctccc ttatacattc caatggctga gtgaaatgac tgccaagaag gactggaaac 3164581 ggcttaaaac atggtaccag caaattgaac caattgcgat gggttatacg aagctggata 3164641 agccgtttaa agagattcgc gatgtgatcg gcgagctgtt ccttctgttg aatgcctatg 3164701 tgcagcaaac caatgatcaa gcgctgtttg agcgctttgc cgcgggctgt ctgccgtata 3164761 cgttcacaga atacagccat catttatatg aaaaaaaacg ctatgccgag tggattgaaa 3164821 ttcatagcct tgtcggcttt tccatcaatg aaatggataa aatgatgctc aaggaaattg 3164881 cagcgagcga ccctgaggcg cttataccgg cttaccatag agaagtggct tttttcattg 3164941 atcagaagaa ccgtagctcg tacaaggaag ccgcccggta tttgaaaaaa ttgcgcaccc 3165001 tgtacaaaaa agcgaaaaag cagaaggtgt gggagcggta tattcagctg ctgagctcgc 3165061 attacaagcg cctgcgtgcg cttcaagaag aactgcagaa aggaaagttg attgatggcg 3165121 agtcttaaag aaattctcat ccacgtcgaa caaatggaag atgggtcatt tacgctctca 3165181 gcctttgatg agaatgagca gcctcttccc tacagccata tgaaaaagca tttgttccaa 3165241 tggcatgaat cctcatttta cggaaccttt ctagaggatg tcagcttcat cgggacgact 3165301 gctgtccttc tatctccatg gatgactgta gagcttctcg gcaaaaactc gttcaactca 3165361 ttcagctccg tgcagcttac agaagaaacg gagccgctga tcgaggcggc atcgaccatc 3165421 tatgaattta tcgcggacgg cgattttatg cctgactatg acgcatggac aaacggtgtt 3165481 tttcgctgga aggaccgcga taatatactg gaaggcttta ctgcggaatg gttttccgct 3165541 gccgtacagg attacatcca gtacgacgat gacctgcggg agaaatggga acatatcaag 3165601 gaaaaatcgc ctgcggttac gacattccgt ggccattttc ttgatgaaga ggattttctg 3165661 gaaggcattg gctggattga cgatcaatct ccatttactg tcggcttgcg cttaaatgaa 3165721 ccggactttg acggagacga atggaagatc gagatgtttt tacgcgataa aaagagcggt 3165781 gctgtagaat tctttgacgg actgaagagc ctcaaaaaat cgtggcaggc gtacagcgat 3165841 aaaatcgcgc gtgagcagga ccgctttcac agaacggttc cgtggctgtc gtttgattcc 3165901 gggacaacgc tgatctcgga ggaagaagcc tggatcttcc tgtcagaagc aagtgagacg 3165961 cttgtcgata tgggggtaga aatcctcctg ccgtcctggt ggcagattgt cagagacagc 3166021 aacatgatgc tgaaagcaaa ggtgtcttcc tccccgcgcg gcgagtcatt tgtcggcatg 3166081 aatgcactgc ttgatttcaa ctggcggttt gcgacaaatg gaattgaact gactgaggct 3166141 gaatttaatg agcttgtcgc cagcaacagg cgccttgtta atatccgcgg gcaatgggtt 3166201 aaaatcgatc cgcagtttat caaacagatg aaacgcctga tggaaaaagc agaatcagag 3166261 ggactccaca tgtctgatat tctggcgcgg gagctaatgg atcagcagga tggcggactt 3166321 gaggattcgg acctgattga tacatctgct tttgccggca ttcagtttga tctgtctaaa 3166381 cagctcaggt cactgattcg aaagctcact gccgcggaaa acctgccgga gcacaaagtc 3166441 agtccttctt tcaaaggaac gctccgccct tatcagaaat acggcatgaa ctggctgctg 3166501 tttctgcggg aaagcggttt tggcgcctgt ctggctgacg atatggggct tgggaaaacg 3166561 attcaaatga tcgcctattt ccttcacgtg aaggaaagcg gccgacaaaa aacgcctcat 3166621 ttgattattg cgccgacatc cgtacttggc aactggcagc gggagcttca aacctttgcc 3166681 cctgatctgt ctgtcgcgct ccattatggg ccgcgccggc caaagggtga tgatttcgcc 3166741 gcgcattatg aaaacgcaga cgtggtgctc acttcatacg gtctgtcaca tgccgatact 3166801 gaagagcttt cttctgtgac atggaacacg atctgccttg atgaagcgca aaatattaaa 3166861 aacgcgcata cgaagcaatc acgcgcaatc aggaagctga aggggcttca ccatatcgcg 3166921 ctgagcggca cgccgatgga aaaccgactg actgagctgt ggtctatttt tgacttcatg 3166981 aataaaggct acctcggcag tttgaccggc ttccataaac gctatgtgct gccgatcgaa 3167041 aaagaccggg acgaaaagag aatcggacag cttcagcaat taatccggcc attccttctc 3167101 cgccggacga aacgggatga agaggtcgcg cttaatcttc ctgagaagct ggaagaaaaa 3167161 gaatttatcc ctctgtcagc cgagcaggca tccctttatg agcagctcgt caaagacact 3167221 tttgaccata tgacatccct gaccggcatg cagcgaaaag cgctgatcct cagcatgctt 3167281 ggacggctca agcaaatatg cgatcatccc gcgctttatt taaaggaaga gcaaaccgag 3167341 ctgctggccg gcagatcagt caagctcgaa aaattgctgg aactgatgac agcgatccgc 3167401 gcccaaaacg aaagctgcct gattttcacg caatacattc agatggggaa catgatgaag 3167461 cggctgcttg aaaaaacgtt cggggaacct gtgcaatttt taaatgggag tctctccaag 3167521 caagagcggg atacactcgt tgagaaattt caaaggaaag aatatccgac actgattctt 3167581 tcactcaaag ctggaggcac cggacttaat ttgaccgccg ccaatcacgt catccattat 3167641 gacagatggt ggaacccggc ggttgaaaat caagcgactg accgtgcata ccgcataggc 3167701 caggagcgct ttgtccacgt tcataaaatg attacgacag gaacaatcga agaaaaaatt 3167761 gatgtcatgc ttgaatccaa gcaaaccctg aacgatcaaa ttatccaaag tgaaaactgg 3167821 attaccgagc tttccacaca ggagctcgaa gaattgttta cattaagcgc tacagcgcaa 3167881 taatcatgac taaaaaagct ggctctaaaa gagccagctt ttttccgttc atagccgtca 3167941 cgccgaattt ccaaaaaatc cgttacgccg gttatcaaca gggtgcgctt ttgtggcagc 3168001 acatatactt acaacaaatg tttcatcata tgtgcgacac cgtgttcgtc attggttaag 3168061 gtgacagcat cggctatcga tttgatgtct tcccgggcat tgcccatcgc tacacctttt 3168121 cccgcagcct ccagcatcga tttgtcattt aaactgtcac ctacagcagc agtttcctcg 3168181 agcggaatat tcagctgttt tgcaagcctc ttcagcgcct gccccttgga agctttgcgg 3168241 gaagaaagct caaagttgtg ctcagccgaa ctgacaagcg tcaaatcttc ggcatgctca 3168301 tatcttttcc agcctgcctc aagcttttct ttgaagaaag aaaagccgag aatattgtaa 3168361 aaatcgattg gctcatcggc ttcaaacagc tcttgaaagg agttaatgta agcaaagccc 3168421 gattggctgt attgcacctc ggccgcctgc ttaaggacag aaagatccgc ttccggattt 3168481 gcgcttctga atctgtcgag ctcaacatca agaagttctc tgccgttttg cggcgtataa 3168541 atcgctgaac ctgtgaatac ctcataataa tagttttccg actcaagcca tgagagaatg 3168601 tcatacgccc gtttcttatc aatcgtttcg tgatgataaa gcctgccctc gggatcgtga 3168661 atgacggcgc cgtttgcact gatgacccat gttttgatcc ccagcggttc aaagattgac 3168721 atgacgtcaa aatgagcgcg cccagttgac accaccactt caatgccgtc ccgctgcgcc 3168781 tgccgcagtg cgttttcatt ttccaagctt acctgatgct tgctgttgag taaggttcca 3168841 tctaagtcaa tcgcaattaa tttcacgttt gtcagtcctt tccttcatcc tgctctgtca 3168901 cgagaagctc aacgccgttt cggtcaagca agtcacaaaa tgcctgattc ggcagcctgt 3168961 ctgtaatcaa gaggtcgatt tcattcagct ccgcatactg ataaaaactg gtgctgccca 3169021 gcttagaatg gtctgcaagc gcaattacct gctttgcctg ctgtatcatt ttccgcttca 3169081 ccatgccatc ctcttcatgc gcaattgtaa tgccatgttc ggaaatgccg accacaccaa 3169141 tcagcgcttt atcaacatgg tagcttgaga gcttttcaat cacagaggac ccgtacagaa 3169201 agcggtgctc cttttccagc ttgcctccca gcagataaat ttcaattccc tctttatcgg 3169261 acagcacatc cgcaagatta atcgaattgg tgattacggt acaatcaacc gcattcaaat 3169321 gctttgcaca tgcctgaaca gttgtagagg cgtctaaaat cacccggtct ccatcatgaa 3169381 taagcgatgc tgcaagcctg ccgatcttat ttttttcctc agacactgtt ttcaggcggc 3169441 cggaatagct ttgaattttc tgatgcacag tcggtaaaat ggcgccgcct cttgtgcgga 3169501 tgatggcatt ctgttcctca agtttcacaa gatctcgtcg cgctgtatcc cttgacactt 3169561 gcaggagcgt acagatctgc tccgttgtaa ttcggttatg ctgttttaaa aaatccaaaa 3169621 tcgctactaa tctttcttct tggtacacgc cctcattcct tttctcagca atcatttata 3169681 agtaattata agtttttatt tgattttatt caacattaat aagtgatttt aagtaaaaat 3169741 gcgtcgagag aaccaatttt tcctaagtag gcaaaaagaa agaaccagtc tggtcgactg 3169801 gtcaattttg aggggatgat gcgaagatcc ggataatagt gaatggatag ataacgggag 3169861 gagcaggggt gtcaatcagc agctttttcc cggggtttag ggtccataaa acgaacagtg 3169921 tcagccaaca cttctgttac atacacgtta acgccttcct cgttttcata gcttcttgtc 3169981 tgaatccgtc cgcttacgcc gacgagagaa cctttttggc aatacaacgc cgtgttttca 3170041 gctgtttttc tccaaagtgt gcaattgacg taatcagctt cgatttcacc tgaagcattc 3170101 ttgaagctgc ggttcaccgc gagcgtaaca tgtgcaactg ccgcaccggc ggaagtgtag 3170161 cgaagatcag gatcttttgt aagacgtccg acaagcatga cctgattgaa catgcgattc 3170221 ctcctctcct tgcggttgta tgtattgtaa atgatgcaac aagaaaagaa aaacgcttaa 3170281 aaatggcttt cagcctctgt ttttatcttt cgttttcatt tttccttcag ctaaaaacat 3170341 cttttgcttt tttcctttga agaaatatgt actttttaaa aaacggaaaa agatttgctt 3170401 tgtcagccag ttttgcgtat tcatgcgcac ataggaagag ccatcccacg caaaccactg 3170461 aaagctcaat tttttttccg gcattgacag cttgatttta tactgctcca tgccatcttg 3170521 tgtttcgtat aaaaaactta ttcttccttt tttgttcaga tgaacctcaa acacttcttt 3170581 acggcttaac atatatgtta cttccttttg aatcaaatga ctttcagaag gaacgccgtc 3170641 aatataaatt tcttttaaac gaaattgatt cataccacat ctctccgtaa tccatagtca 3170701 gttacagtat aatgaaaaaa tagaaattat taaatgtttc gctcatacaa aattctttag 3170761 ccccaacatt gcaggatttt ttcctcgaaa acgtttatgt tataatggaa ggcaagaaaa 3170821 ctttggaagt aatcggggtg agaagaaatg aaaaccttta aactggttga cctgaatgtg 3170881 gaacgagtgg acaaggaaga acaatcaatt gaacagtttc cccttattga cggactgatt 3170941 ataaataaag aagacggtga aaatcactgg ctgattgagg cgcttgtaca gaaagaacat 3171001 ctgtcttttt ttgaacagct tcaaaacagc caatctgaag ccaaagtatt tgtaacgatc 3171061 acgaaaaaaa gcaatcgccc cgcccagctg acagcagcag tgaaaaatat cgtcaagctg 3171121 gaagaaagca ttcaggtttt actctacgga caaatggtca caagaaaaca gcagggcact 3171181 gaaaccattc tcgagtccct tgtaaaagag ggctatacag gaacaaaact cattgaggca 3171241 tttaagcaaa aattataaat atgagggggc atgttcccca aaacagactc agaaccgaag 3171301 agcatcacaa tagacattta gaatagatat gttctgcatg aaaaaagctg ccgttttgaa 3171361 cggcagcttt tctcttcgtg ctttcactct tgcatattta atttgtatgg ccaaaagaat 3171421 caaccaattc ccctttcaca acgaggcgcc cttcggtttt gaccgccttg tcacatgtga 3171481 ttaacgtaat ctcctttttg tttgtctcct caactacatc tgcatccatt tccgatatga 3171541 tgtctttcga tgttacagaa tagatataat cctttttaaa atccgtgatg acaatttggg 3171601 cacctgtttt tatgttttcc agaggtccga acagaagatt cttttgcttc aaatgatggc 3171661 ccgccaacgg ataatttccc tcacccattt tttgatcccg gcgcattgtt gccgccccta 3171721 tcaaaagatt ttcattggtt gtgcctttta cgatcggaag ctccagatcg acacttttaa 3171781 ttgttatccg ccgccttgat tgtgaagtaa aaataagtat atttcacgtg ctttcgacgt 3171841 tctccacttg actggaatgc tttaatggcg atcccggcat ctgtagcttc aggctttcct 3171901 tcagaggaat cagaaatctc aaactctatt ttctcagtgt tcagcacata accggctggc 3171961 gctttcgttt caacaaaagc gtattgtccc ggtgcaaggc ctgaagctgt gacttgatga 3172021 tgccggatat gactggtttc gaagtctgta tgaaaattcg cgaacgattc agcatggttg 3172081 atcttccggt tctgatcatt acagctgcca ttatcggcca tgacaaatac aaggcttttc 3172141 atgccggagc gaatgacatt ttgcaaaaac cctatcatta ctctgaattt atggcgcgta 3172201 ttcaaaacct gataatgatg aaacatacag caaatcaagc cacaagaatg gaaatggcgt 3172261 ttctccagtc gcaaatcaag cctcattttc tttataatgt attaaacacg attatttctc 3172321 tcactcattt ggatattgaa aaggcccggg aggtaacaga ggaatttacc aactatttaa 3172381 gaatgagttt tgactttcaa aatacatcag ccatcagttc cttcagacat gagctttcga 3172441 ttatcaattc ctatctttct atagaaaaga cgcgattcag taatcggctt gaggttcttt 3172501 tcgatataga tgaagacatt gactttatcc ttccgccttt aatgattcag cccttggtgg 3172561 aaaatgccgt tcttcacggt gtcagcaaga aaagaggcgg aggatggatc aaactgacag 3172621 ctaaaaaaca aagcaaaaat gagtatcaca tcaaagtaga ggataacggt cccgggataa 3172681 ctccggaaaa acaaatagat ctcttatcaa cggattttga tcgcagcgtc ggattgaaaa 3172741 atatcaatca gcggctgaaa catttttgcg gaagcgagtt gatgatcagc agcactccgg 3172801 atgcaggcac ctctgtctca atgctcattc atctcgctga aacaacagga agccctaaag 3172861 aactgaagga cacagaacga acctaaacga aaattgagat aaaaaaagac gccgtttcta 3172921 acggcatctt ttttattccg gcgactttgc ttgctgcttc agcaggtctc tgatttcttt 3172981 cagcagctcc tcctgcgcat ccaccgcttc ctccgcagcc tcttcttctg cttctttttt 3173041 gcgccttaac ccattcaaag tccgaatgac gataaaaatg gagaacgata taattaagaa 3173101 gttcacaatc gtctgtataa agctgccata tttcactaca gcatcgccaa acgtaaacga 3173161 caggcctgaa aagtcaagcc ctcccagcag caaaccgacc aaaggcataa tgatatcatt 3173221 tactagagat gtgacgatct ttccgaaagc gccgcctatc acaacaccaa tcgcaaggtc 3173281 tacgatattc ccccgcatgg caaaggcttt aaattcattc cacatacaat cacctgcttt 3173341 tctatatttg taaagaaaaa aagacaaatg tgccgctggc catctgcctt ttttcaatta 3173401 ttctccgagg gcaaaagtca gttctacttc gcaaacgact tcgccatcaa ctgtggcaac 3173461 gccttttccg cgcccgattg tgccgcgggc acgaatgatt tcaacctcaa ggtgaagctg 3173521 gtcaccaggc ttgacttgtt ttttaaagcg gcagttatca atgcctgcaa aaaaagccag 3173581 tctgccgcgg ttttcttctt taatcaacat cgcaacagct ccgacttgag cgagtgcttc 3173641 tacgattaat acgccgggca taaccgggta ctgaggaaaa tgtccgttaa agaactcttc 3173701 attagcggtt acatttttat agccttttgc ccgtttgccc tcttcaactt ccgtaatccg 3173761 atccacaagc aaaaacggat aacggtgagg aataatttct ttaatttgct gagtatcaag 3173821 cattgtcttg acatctcctt catctgcatt agtatgtata gcaatcatca aagatccaat 3173881 ctgtacattt gaaaagtata ttatgaatta atctcttttt caaccgcgct aaaatgtaac 3173941 caactgtcaa tgagagccgt caaaagttat gatatgataa ttatagattt taccaatagc 3174001 aaagaggtag gaaaatgatt tcgaagttta ttgaaaaaag aatgctaaac atgttagacg 3174061 agtggtattc cgcaatgagc aaacgcaaaa tgaatcacgt ttgcacactg aaagagaaaa 3174121 ttgatcagca ccttccaaag atcaaaaaga acacaaaact ttggatgcgt tatcaattgt 3174181 ttcaggcccg ccatcagctg ctttttgaaa accagaacgg actcgattca ttgttcgatg 3174241 gcctatatgg cctggaagac aaaatggatg atgaattgaa atattatctg tattttttct 3174301 ctgggttata tgagatggta aaaacagctc cgaaacatgc agtacatcat tttaaaaaag 3174361 ctgaacagta cctggccgcc attcacaata cgtttgaagc cgctgattta tattatcaaa 3174421 ccgccggcgc ctattacttg atgaaatcac cgccgctttc cgtccaatac gtcaaaaaag 3174481 cattacacat ctatttgcac caattcggct atatcaaaaa ggtaatcacc tgtaaacttt 3174541 tgctcgccgt gaattatatt gatcaagaac gctatgaaaa agctgaacag cttttcaaag 3174601 aaatcattaa gaaaacccag caactacatg acgaaaacct gctatgccac gcttattata 3174661 accttggctt tttaaaagcg accgagaaaa aagaccagga agcgcttctt tactttagaa 3174721 aagtattaaa gaatcaagaa tttgaaatga attcaccagt ctcatatctt cattgtgtgt 3174781 acgagtctgt cagagcgctt tttaaaacag ggaacatcac agaagctaaa gccgtccttc 3174841 aaaaaggaaa agaattatct gaaaaggtag acattcaaac catttattta aaattaaaaa 3174901 cgcttgaagc cctctacaca tcagccgaag acccttatga gcagctgctc gaatatgtgc 3174961 ttgaattaga aaaaatcgag gcgtgggtgg atttagaagt gctgttagaa gatattacgg 3175021 aatactacaa aaaaaaggac gatttcgaaa aagccgcttt ttttatcatg cgcggctgat 3175081 tgaaaaacgc ccattttctt attatctgac tgaattgatt aaaccgagca tttgatctcc 3175141 cattgtgatc gttctgctgt tcagctgata tgaacgctgg gacgtgatca aatctgtcat 3175201 ttgttctgaa atatcgacat tggacatctc aagtgagccc tgctgcatgc cgatgttttg 3175261 tctattagcg ccgttcagct cttcaaaagc tgccgcatta tcaatagaga aaaggttatt 3175321 cccttcggat ttcagctctt gagggttatt cacttggaca acgccaagat taaaccgctg 3175381 aaccgcgttt ccgtcagatg cggttaaggt gccgttctta ttaatggtga tattcttcat 3175441 tgagctgtcg atgttcactg tattgccgtt ctcatcaagt acgggatacc catttccagt 3175501 gacgagctgc agctggttgg cattcgcagc ggacggcgtt acatacagcg ccccgtccct 3175561 cgtatactgg cggtttccat ttacatttac ctgaagatac tggtatggag acgtaaatgc 3175621 gatatccaga tcgcgatcgg tcttctgaat gcttccttga tcagagacta ggcgtgaact 3175681 catcatcgct ccgacgccaa ggcgcaagcc gggcggcgtt tttcgggctt ttgccacttc 3175741 ctcgtttttt tcatcaacct gatcgaattg ctgtctgaca agctcagaaa aattcgtatc 3175801 ttttgcctta tagccggttg tgttgctgtt tgaaaggttg ctgctgattg tgtcaatctg 3175861 ctgctgcagc tggtttaagg ttgttgatgc cgttagcatt gacctgagca tagttgatgt 3175921 cccccgtttt tttcttccgt tttcttaaat ttttccaatt tcatttgctg ctttatccat 3175981 acttttatcg taagcctgaa taaccttctg attcgcctca aacgatctgt acgcttcagt 3176041 catttctgta taggcgcttg tcacatccac gtttgaaagc tctgagacgc cttgttttaa 3176101 tgaataggct acctgattat ttccggctgc gcttggcaga tcattaccgt ccgccgtgct 3176161 gtacaaatca tttccgtccc gtttgagatt gcggacatct tccgccattc tgacatcaat 3176221 ctggccggct gtgcgtccgt tcgttgtcac agtaccgttt tcagacacag tgaaattctc 3176281 attatcaaca gtgattggct ggcgatccgt cgataaaata gggcgtccgt tgatcgtcag 3176341 ctgattgttc tcatttagtg aaaatgtgct gctttttgaa taacggattc catccgctgt 3176401 ttgaaccgga taaaaaagag cagctttttc attggtttcc gcactcatcg gaacttgatt 3176461 ttcgatcaat gcaatgtctg taggctggtc tgtggacttc aggcttccct gtgtaaagag 3176521 aggcttgagc tcctgcatat atactccggt attcacggaa ccgatttccg tccttgatgt 3176581 cccggccgga gattttgatt ctattctgct gagcagcatc tcagggaacg cgcgcataga 3176641 gccttgatca gctttatatc ctgatgtatt tgcgttagca atattatttg aaagcatttc 3176701 cgttcttcgc tgctgggcaa tcattgcgga tgttgctgta tataatcctt ttaacaaatt 3176761 tcccacctct aaaaatggca ttttttccag ttgtcatata ggaacgttcg ttctataata 3176821 aaaactcagt attttatcct attatcgtca tttaacatct tttcgtgaag gctttttcat 3176881 aaaaaaacct cattcttttt cagaatgagg tttgtgaaat cagcttagtt tgcgtttagg 3176941 aagcttgtcc atattatcaa gcatgacacc tgtgccgatg gctacgcaat ccataggatt 3177001 ttcagcaacg aggaccggta ccttcagctc ttcagcaagc agctggtcaa ggccgtttaa 3177061 gagcgcgcct ccgccggtaa taataacgcc gcggtcaata atatcagcag aaagttcagg 3177121 cggtgttctt tcgagcactt gttttgcagc ctgaacaata acagcgacag attcacgaag 3177181 ggcttcttca acttctttac tgtttactgt aattgttctt ggaagaccgg aaaccatgtc 3177241 ccgtccgcga atggaaattt cctcgtgacg tgcgtctggg aaaacagttg cgactttaat 3177301 cttaatatcc tccgcagtac gttcgccgat cagcagcttg tactcgcgtt tgatataatt 3177361 taagatttcc atgtcaaact tgtccccagc cattttaata gaagaggagg tgacaatatc 3177421 gcccattgaa ataaccgcga tatccgtcgt cccgcctccg atgtctacaa ccatgttacc 3177481 gcttggctgg aatatttcca tacccgcgcc gatagcggca actttaggtt cttcttcaag 3177541 gtacacatgt ttcccgccgc ttttttctgc agcttcttta attgcttttt gctcaacgga 3177601 tgtaatattc gtcgggcagc aaatgagcat gcgcggcttt gagaacaggc cttttacatt 3177661 cagcttgtta ataaaatgtt tcagcattgc ttctgttact tcaaagtcag caataactcc 3177721 gtctttcagc gggcgaatcg caacaatatt cccaggtgta cgtccaacca ttcgtcttgc 3177781 ctcttcgcca accgccagca ctttgccgct gtttttatca agtgcaacaa cggaaggttc 3177841 attcagaaca attcctttac ctttaacatg gatcagtaca tttgcagtac cgaggtcaat 3177901 accaatatcc cttgcaaaca tctatttata tcctccttga aaatctgttt cacagtaaat 3177961 atccacattg tgccctaatt atatatatta tcataaaata tagaaaaaaa gttggaagca 3178021 caataagttc tttacaaatt tttgcggatg ttttatgaac gatttcaaga aggcaatgcc 3178081 aggtgattac gattgctgaa caggctctcc ttcgagaatt tcatcttttt tatatttgag 3178141 ctttgtcgct tctcctcctc ttaaatgcct gatggattta tgataatcga gtatttcttt 3178201 cacttcgttt gccaagtcgg ggttaatttc aggcagacgc tctgttaaat ccttgtgtac 3178261 tgtacttttg gaaacaccaa attccttcgc aatgacacga acggttttct ttgtctccac 3178321 gatgtacttc cctatcttga ttgttcgctc tttgatgtaa tcgtgcacac cactcgacct 3178381 ccctaaaatg gatgtgagaa gtgtgaaatg agatccgtat tctgtaaaga gtcgttcatt 3178441 atgccgcttc ttcgttgtat ggttttaaaa gtaagtttgt gaaatatgcc cacgatccct 3178501 cacctcaaac actctctttg ttaggtttgt aacagtgtat tagcattctt ttgggaatat 3178561 gctaaaaact caataaggac aaggggtgaa acgaactttt tcagattcag caaactattt 3178621 cgcgtcacta aattttcatc tttacaacta ttgatcgctc ctgtaaaatg aaataagcaa 3178681 ttagttactt aggtaagttt tttagaagga gaccgacatg tcctacgtca acagacacct 3178741 cattcatcaa atcaaccaaa gcgcccgcct gattgccaag aaagccaatg aacagctaga 3178801 gccattcggc ctttattcat ctcaatggtc agttttatat tgtttgcgta cgatcggacc 3178861 aatgactcaa aaagagattt ggtcctattt aaatgtggaa gcgccgactg tgactcggac 3178921 gatcaaacgc ctggaggaga acggctgggt tcagagacgg caaggtgaag acaaacggga 3178981 aaaacttgtt gtcctcacaa aagaagccga gaaaaaatac gaagaaatca atgtgaaaat 3179041 gttgaaattc gaggaagagc tgcttgcaga tttccgggat gaagataaag aagctttttc 3179101 tcatttattc cgcatgtttt tacaacaatg aaaataagga agtgacatac atttgaaaaa 3179161 agcggatgcg atatggacca aggattttat tatggtcctg cttgtcaatt tatttgtgtt 3179221 tgtgttcttt tatacatttt taactgtatt gccgatctat acactgcaag agcttggcgg 3179281 cacagaatca caaggcgggc ttttaatcag cctgttcctt ctgtctgcga tcattacacg 3179341 gcctttctcc ggagccatcg ttgagcgttt cgggaagaaa agaatggcga ttgtatcaat 3179401 ggcgctcttc gccctatcat cttttctgta tatgccgatt cataactttt ccctgctgct 3179461 cggattgcgg ttcttccaag ggatttggtt cagcatttta acgactgtta caggtgcaat 3179521 tgccgctgat attattccag ccaaacggcg cggtgaaggg cttggatact ttgccatgtc 3179581 tatgaacctc gctatggcga tcgggccttt ccttggcctg aatttgatga gagtggtaag 3179641 ctttcctgta ttctttacag cctttgcgct gtttatggtt gcgggcttac ttgtttcgtt 3179701 cttgataaaa gtgccgcaaa gtaaggacag cggcacgact gtattccgtt ttgcgttctc 3179761 ggatatgttt gaaaagggcg cactcaaaat tgcgacggtc ggtttgttta tttctttctg 3179821 ttattcaaca gtcacatcat atctgtctgt attcgccaaa tcagttgacc tttcggatat 3179881 cagcggatat ttctttgttt gttttgcggt gacaatgatg attgcacgcc cgttcacagg 3179941 gaaattgttc gacaaagtcg gaccgggcat tgtcatttat ccatcaatcc tgattttctc 3180001 tgtcggactc tgcatgctgt ccttcacaca tagcggctta atgcttctgc tttcaggggc 3180061 ggttatcggt cttggctacg gatcaatcgt tccttgcatg caaacattgg cgattcagaa 3180121 atctccggct caccgctccg gttttgcgac ggcaacgttc tttaccttct ttgacagcgg 3180181 aattgctgta ggatcgtatg tattcggatt gtttgtagca tctgccggct tctctgccat 3180241 ttatttaaca gcggggctgt tcgttttaat tgctctgctt ctctacacgt ggagccagaa 3180301 aaaacctgca gaggctgaag gaaaagtgtc tattgcagaa taacttgtca gactgccggg 3180361 aaatcccggc agtctttttt ccattaaaac acggcgccct ctcggttgaa cgagagaacg 3180421 ccgcttatag caattattca atgacaggcc gcgcaggtga atcaggatct aacgaaaaat 3180481 cataggacgc ttcatcacga aacatcggat cggcatatat ggattgttga tcgttttttg 3180541 ttgcttttcg atacgaagaa aatgaatcat attctttctt tttccacatc catatgccgt 3180601 cttgatccgc ttccttgtgg tacacgttat gattgaccgt attaccttcg ttttctgtaa 3180661 agtcgtttcc gataaataat ctggaatcac cggccgtcaa tatattcttt tcaattgtgt 3180721 tgtttttcgt atcgtactgc agcagcagct gtccgccgta cagtcccttt gtgtcattcc 3180781 ggtacataat attgcgggca atcagagaat tgctggtgcc gccccgcttt ttgtcatatc 3180841 ctccgattga aataccggtg tacgcattgt tgtacacttt gttgtctgtg atctgaatgg 3180901 catttgcata ctttcctttg tgttcagacg ttgcttcaat cccaatatcg ttatcgtaaa 3180961 ctgtgttgtt cttaatttcg atatcgtgtc ctccatcgac ataaatcccg cccgctgagt 3181021 attcatctcc ataagcagga ttgccgtaag tcgagttttg ataaactgta ttgttttcta 3181081 cgactccgtt tcgcacgtaa tcgtttttat ccgcggttcc ctcataacca attagatcaa 3181141 tcccgatgtt attattgttg cggaccacat tgcctgcaac tgtgaagccg tcgatattac 3181201 cgttcagcac aactgcttca ctcgctccaa gcgtcagttt ctcaactgta ttgtcctcga 3181261 ttcggatgtc tttcatgctg ccagtcccat aaactgcgat tccgtgagca tttccttcat 3181321 ccgctgttgt cttaatcccc cggatgtgat tatccttaat ggcgatatga ctgctggacc 3181381 ctgatacata aatccctata gcagttgctt cctcagatga aacagaaaga tcttgaattg 3181441 ttaaaccgct gatggcaatg tcatgtttat cgtgaatacg aataagcggt gtttcatatt 3181501 cagcgttcgc aacggattca ccgctaatca cgacgttttc attttcatag tttcggaatg 3181561 tgataggctt tccgtccgta ccgctgtgct ttacatcaag ggtctcatga tacgtgccct 3181621 cccgaatcat gacagttgtg ccggcagcag ccttctcaga tgcgtgtgcc aatgtacgaa 3181681 acggcttttc ttttgttcct tcattttgat cactgccatt tggcgaaaca tacagataat 3181741 ccccagatcc ttcctcattc gcttttgtct tatcataaac gaaagcgagg atgacagacg 3181801 ttaaaacacc cgccaaaaga ataaaatacc attttctcat tttcgattcc catttcgttt 3181861 tagaatagat ttctaaaacc attataaatg ttctatttat ggaaaaccat ttcaaaaata 3181921 tgaaaatata ccgtctaaat agatcttatt cagcctggcg gacctgcgca tgttcaactg 3181981 tttcaattgc caatgatgca ggcgggtgaa cacgcatcag aacaatgtag aaaagaaagg 3182041 aaatcagcac acctacaaac caagaaatat cgtataagct cttcaataca ggaacataca 3182101 tgccaatcag cgaaatcagc gctcctaaca ttgtggctgc aaacgcacgg taattgtagc 3182161 ccttccaata cacataccgt cctgtttcgg aatacaggtc atctaccgag agctcacgtt 3182221 tgcgaatgat aaaatagtcg gccatcatca cgcctgccac cggtccaagc atgccgccta 3182281 ttaagccaag aaacgcatac acgcttgtcg cgctctccat cagcttccac ggaaccgtaa 3182341 ataaagcgag caacgctgtg ataaagctgc cacgtttgaa attgatatat ttcggcaggg 3182401 cattcgctat atcataagcg ggtgatacga tattcgccgc gacatttaca gagatcgtgg 3182461 cgatgcagag tgtgatcacg gacaagacga tgacataagg gttatcaaac cgcgccaaaa 3182521 tatcgacaac atcccaaatc ggctctccga acgcgacctg cgagccggag gtcaccgtaa 3182581 tacttgcgaa tgcgaacagc gcaaacgttc ccggcaaacc gtaaaattgt cctttgattt 3182641 gctctttttg tgtttcagca aaccgtgtaa aatcaggtat atttaagatc aatgtcgccc 3182701 agatgccgat gatgccagta actccggcag caaacggcca gaatgtttct gaaaacgtat 3182761 gaaactttcc tggttgagag tatatcgggc ccaatcctcc agcaatatca acggcccacc 3182821 ataccatgcc gccaaatacc agatacacta aaggccctgc ccacacctca aaacgtttaa 3182881 tcgactccat gccgtgatgc aatacgagta aatgaatggc ccaaaagaat acaaaggaaa 3182941 gcaaaccgga caagtgaatg ccgagaatgt tccactcgcc gccaatttct ccccaacctg 3183001 gccacatatt caaaagcaaa atgttcagtg ccgtgctacc cgcaaaggtc tggatgccaa 3183061 gccacatgat agctgtaaac gcccttagaa gcgcggggat attcgcgccg tatatcccgt 3183121 aagaagcccg aatgatcact ggaaacggca gcccgtattt tgtccccgca tggccgttta 3183181 aggcaagagc gccaaatagg ataagtgatg ccgtaataat gatcgccagc acctgccaag 3183241 gcgaaaggcc gatcgcaatt aatcctccca cggtcgcgta ggtcggtatg ttatgtatac 3183301 atcccatcca aatggaggca aagttcattg ctttccacgt ccgtttttcc tgtcccaaag 3183361 gcaccagatc ttcattgctc agcctgttgg attgctgctg actctctttt aatttcatag 3183421 ccggctcccc tttccatatt gtctatatgt cgtcacacgt tatgtttttt gacattagat 3183481 gtcacttaat ataactgaag agtcagacaa taacactggc tatgatatac aattttcccg 3183541 tttgtatttg aacagcttaa acaagaaaaa gagacagacc tcagagcccg tctctttctt 3183601 aagatgcagt tttcattaat gcagcaaatc tcacagccat taacaggctt gctccgcccg 3183661 ctataatcat aatgattccc atcatatcaa aatgggctgc cgtgatttct ttaccaaaaa 3183721 gaatgccaag gatcaccgaa gacaaaatcg atcctaggta acggcaggtt tgaaacaggc 3183781 ctgaagtcgt tcctaccatg ttggaaggac tcgtttccag catcgctgcc tgaagcgcga 3183841 cattgcccag tccgtagcct atacccaaga gcgacagaat gaggccttta ccgatggtct 3183901 ggacattgat aaaaaagatg gttaagagca cggctccagc cgtcatcaaa agcgctcccg 3183961 caaagatcgg cttgacgaca ccagatcggt cgatccattt gccggttaga ggtgacacaa 3184021 cgatgctcat tccagacata aacagcataa acaggccgct cgtttgaaca gaaagatgca 3184081 tttcatcctg aaagtaactt ggcaaaccaa aaaataaaca atagaagaaa acattcaata 3184141 aaataaactg aacatacacg gctgacaggt ttcgctgtgt tttaaacaga cggacatcaa 3184201 taaacggctt atccgttttc agctcgcgcc agacaaacgc acagagcaga agcaagccaa 3184261 gcacaccttc aaccgcatgc ggcgacgtgc tgaacgacag caaaaaggat agaaggaaaa 3184321 tgattccccc ggcaaataaa acaattccaa gaatatcgag ctgccgaata atggttttga 3184381 ttcctgcccc ttttttctga tctttcggga acatatacag gcccaataag aagctgagga 3184441 taataaacgg caaattaacg ataaagatcg ccggccagcc tccccataca atcaaaaacc 3184501 cgccggctgt cggccccagc gccgtcatgg cggacgcaaa aatagagagt acagccaagg 3184561 ctgaagcttg gcgctcatga atatgattcc gaatcaagcc gacacctgac ggataaatcg 3184621 cactgctccc caccgattga aacagccgca tgaccaataa tgtcataaac gtcggcgcaa 3184681 acggcgcccc gatggcagaa accgcaacaa gaataagccc gaataaaaac aagcgtttcc 3184741 gcccaatcaa atcaccgagc tttcccgtta cgggctgcgc tacggcactc gccaagtaaa 3184801 acgaggaaat cagccaggaa accgttgtaa acgagaggtg aaactcatgc tggatgctat 3184861 ggagcgcaag agagatcata gacgagttca gcggattcag cattgttccc gaagccacag 3184921 ctgttaaaaa aacagctcgg ctttttttcg ataacatcat ttcacttgtt ccagaaactc 3184981 ttccgttgtc cgcgatttac cgattctcgg gaaaataaag cgcagtgtgg cttcatgctc 3185041 ttcatcgcta aatgtggaca tggcatctgt aataaaaatc tgctgatagc caagctgaaa 3185101 tgcctcccgt gctgtgcttt ccaccccgat attcgttgcg atgccgcaca atacaatcgt 3185161 atcaatgccg cgacgtctca gctgcaagtc taaatctgtg ccaaaaaaag caccccattg 3185221 ccgttttgtc acagtataat cgccatcctg cacaccgatt tccggaacaa attcggccca 3185281 gtccgccggc atttcccctg aacctccctg cgcaggctca tccgtttgcg gcttcagggc 3185341 gtccgctcca tcatgaaagg ctacatttac aaagctgatg aacccgttat gtttccgaaa 3185401 ttcatctacg agctttttcg cgttcgggac aacctggccg ctttgatcaa tcggcacaat 3185461 tcccttttgt aaatcaatga taaccaatgc tgttttttga aaatcaatgt tgagtgtatt 3185521 catcatacgt ctcctcctga tactgttagt gtttctcaca ttgcatattt tactcttcac 3185581 actgcctaag ttcttttatg atgcttgtga aattctcaga aggagcgttt tctcatgatt 3185641 tttcttttat gtagtagtaa caggttgtgc atacgaacaa accggcaagc actgtaatca 3185701 taaagggcgt catcgcttca tcacctgcct gctgtctatc ggttcctgcc tgaaaatgcc 3185761 catgaatttg cggcggtcca tccaaagcag gataagacac ataaccatta atatcgtgct 3185821 aagatcctgc acgccaatat caaaacaata gttaatcaag acgatgttca caataatggg 3185881 cataaaaata accgccccta atgcagccgt tcgcggaatc agtaataaaa cagctgccag 3185941 gatttcacca aaacctataa acagttcata gacatgagaa taaccgaaaa atgtccacgc 3186001 gatcgtaaac cccttcccgg cagccgcctc gatttcaggc gtcacctcgc caaactggcc 3186061 aattaccact ttcgccagac cgtacacgaa aaaattaaag gctaaaaaca atcggaacgt 3186121 cgcgggaatc gacttgcgta ccgctttcct cagcctgccg cctttattca tcatacatcc 3186181 ccctcagtgt attatttgat gtagtacact taatacagta tagagtattc taattaatgt 3186241 caattccctt ttcagctcat atgaatagtt tcttttatag atacaaagtc ttatatcgca 3186301 aaaaatgcca ttctccttcc tttccatccc tcgataacat ttctcaaaaa ccatgtcagg 3186361 aaatcttaca tgaaaatgtt ttatcattct tttttctcta taatgaagaa atataataat 3186421 tgctttttat tctgaaagat acggaggaat gagacatgca aatgggcgat acagttttta 3186481 tgttcttttg cgctttactc gtgtggctga tgaccccggg attagcgtta ttttatggag 3186541 gaatggtaaa gagcaaaaat gtgctgagca ctgccatgca cagtttctct tccattgcca 3186601 tcgtttccat cgtttgggtg ctgttcggat atacacttgc cttcgcacca ggcaattcaa 3186661 tcatcggcgg gctggagtgg gcaggcctca aaggggtcgg atttgatccg ggagattaca 3186721 gcgataccat cccccactcg ttatttatga tgttccaaat gacgttcgcc gttctgacta 3186781 cagcgattat ttccggggct ttcgcagagc ggatgcgatt cggcgctttt cttttattct 3186841 cggttttatg ggcctctttg gtttacacac ccgtagcgca ctgggtatgg ggcggcggct 3186901 ggatcggcca gcttggagcg ctcgatttcg ctggcggcaa tgttgttcat atttcctccg 3186961 gggtggcagg acttgttctt gccattgtgc tcggcaaacg gaaagacggt acagcgtctt 3187021 ctccgcataa cctcatttac accttcttag gaggagcttt gatttggttc ggctggttcg 3187081 gctttaacgt cggcagcgca ttgaccttag atggtgtggc catgtacgcg ttcatcaaca 3187141 caaacaccgc ggctgcagcc gggatcgccg gctggatctt agtagaatgg atcattaaca 3187201 aaaaaccgac aatgctcgga gcggtatctg gggcaatcgc cgggcttgtc gccattacgc 3187261 cggctgccgg atttgtcaca ccgttcgctt ccattattat cggcatcatc ggcggagctg 3187321 tttgtttctg gggagtattc tcgcttaaaa agaaattcgg atacgacgac gcgcttgacg 3187381 cctttggcct gcacgggatc ggcggcacat ggggcggaat cgcaacagga ttattcgcaa 3187441 caacctctgt taactcagcg ggcgcagatg ggttatttta cggtgatgca agcttaatct 3187501 ggaaacaaat cgtcgccatc gccgccactt atgtttttgt atttattgtc actttcgtta 3187561 ttattaaaat tgtaagcctc ttccttcccc ttcgcgcaac tgaagaagaa gagtcacttg 3187621 ggcttgactt aacgatgcac ggggaaaaag catatcaaga ttctatgtga ggagtgacgc 3187681 tatgagcggt caaatgttca aggtagaaat tgtaacgcgt ccggcaaatt ttgaaaagct 3187741 gaagcaggaa ctcggaaaaa tcggagtgac ctctctgact ttctccaatg tacacggctg 3187801 cggccttcaa aaagcacata cggagctcta tcgaggggta aaaatagaaa gcaatgtata 3187861 cgagcgttta aaaatagaaa ttgtggtcag caaggttcct gttgatcaag tgacagagac 3187921 cgctaaaagg gtgctgaaaa cgggatcacc aggtgacggt aaaatatttg tctatgaaat 3187981 cagcaatacg atcaacatcc gcacaggcga agaaggacct gaagcacttt aatatcggta 3188041 cgagattcgg acactccgga tctctttttt tgtgcacaga atccccccag aaaccgcgat 3188101 tcctcttcga attctcttca agcgccgtta tttcagacaa tctctatttt tatttgaaac 3188161 ttttcatgag taagattagt ctactaaata taaaaatgta aaaggtgatt atttgaacta 3188221 cgaaattttt aaagcaatcc atggactatc tcatcacaat tcagttctcg attccattat 3188281 ggtcttcatc acggaatatg ccattgtcgc ctatgccctt atcctattgg caatctggct 3188341 gtttgggaac acacaaagca gaaaacatgt gctatacgca ggcatcacag gaattgcagg 3188401 ccttgtgatc aactatttga ttacgcttgt ttatttcgaa ccgcgcccgt tcgttgcgca 3188461 tacagtgcat acactgattc cgcatgctgc ggatgcttca tttccaagtg accatacgac 3188521 aggtgcatta gcgatttcta ttgcgatgct tttcagaaac cgcaaaatcg gctggccgct 3188581 tgtcattttt gggcttttga caggcttttc gagaatttgg gtgggacatc actatccggt 3188641 agatgtattg ggcagcctcg ttgtcgccat cattatcggg ttccttttct ttagattttc 3188701 agatctgctt cgcccgttcg tcgatttggt cgtgaggatc tacgaagcca ttatcaataa 3188761 actgacgaaa aaaccaaccg atcaaaattt ctaagaaaga caaaagccgg cgtctgaaat 3188821 caagacagcc ggctttaata tttctcatac atctcttgtt ttcttcgctt cgccaacaca 3188881 tataaaccat aaaacaaccc aattccaaca gcatcgatga gcacatcccg gatacaacca 3188941 ttcctgctga agaagagctg aagaacttct gtgaaaaaag caaacgcaaa tgagccggct 3189001 gcagctgatc ttatgctgcc ccgctgtttc cacagcaaat atgtcagcac aaagaaggaa 3189061 aacgcgtgtc cgattttttg aataaacgct tcaggtacag taagctcagt aaaatccata 3189121 actaaaaatt gagacagatc agggtgcggc tgaaaatgaa aagccaccgt ttgcgatacg 3189181 accatgccgc tgaagctttc cgtacagaca gaaagcagga taaaaaagat ccagcctgcg 3189241 agcaataggc ggttcatgac ataacctcct ttataacgta cgtgcctaca tgtaactaca 3189301 tagacggtaa aacaaagcaa aaagtaacag aaaaaaacgc ccatcacaag gatagacgtt 3189361 ttcttcatta agactgttca gtgtcttctg ttgtgctgct ttctttagaa ccagatttgt 3189421 cagttgaatc atcctttttc tcaccggatt tttcttctgt tcctttttca gttgatccgt 3189481 cctttttctc ggaagattgc tgaatggatt cttctgtttc ttgggtggca gctttttcaa 3189541 tagaagaaac tggtttgtcc ataaagttta acggattcat tgcaacccca tctttacgga 3189601 tttcaaagtg cacgtggttt ccgctgtctt cactgtaaag gttcttgcca gattttccga 3189661 tcacttgatt ttgttttact ttgtcacctt gctctacgct tacttcggaa agagattgat 3189721 acacagtcga taaaccgtcg gcatgttcta cttccacaac atatcccagc actggatctt 3189781 tttcagcttt aacaaccgta ccgctcagag aagcagagac atcgaaatct tttccgtctt 3189841 tctcagctaa gtcaattcct ttgcttaggc tgtacgtgtt attataggta acgagtgctg 3189901 cttctttctc ttcttttgcg gcatcggttt catagaactt tttcacaaca gaaacgtttt 3189961 cagaatcaac aaccggcatt gcgacatttt ccattgactt tcctacttca actgcatcgt 3190021 cgttgttgtc atatgcggag tttccgccgt tatcagccaa ctgatccttt acctcatcat 3190081 ttgatactga ttgataccaa aggacagctg ttaaaatgac ggccgcactg actaagtaaa 3190141 ttgcagggaa cacccagcgt ttacgaaaaa actgctgaag ttttttgact tgagaagttt 3190201 tcttttcttc ctctctcatt gtttcatcac ctcagcaaca ttctgaacac ttttctgaaa 3190261 atatatacaa cctatccaaa aaaacttttt tagatgtagt ttgcacagac tgaacgaaaa 3190321 tatgtatttt tttgagagga gtgccaaaaa cgtatgaaca tgacattgcg tcttgctgaa 3190381 catagagact tggaggctgt tgtggcgatt tataattcaa cgattgcttc tcgaatggta 3190441 acagccgata ccgaaccggt aactcctgaa gaccggatgg aatggttttc gggacataca 3190501 gagtcacgtc cgctctatgt ggccgaggat gaaaacggaa acgtcgctgc ctggatcagc 3190561 tttgaaacat tttatggaag gccagcctat aataaaacag cggaagtcag catatacatt 3190621 gacgaagcat gccgcggcaa aggtgttgga tcatatttgc ttcaagaagc gctccgcatt 3190681 gccccgaatc ttggcatccg ctcacttatg gccttcattt tcgggcataa taaaccaagc 3190741 ctgaagctgt ttgaaaagca cgggtttgca gaatggggac tattccccgg catcgccgaa 3190801 atggacggga aaagatacga tttaaaaatt ttagggagag agctttcatg attagtctgg 3190861 ataaagatga aaacgaaatt gaacatcata atgaagaaaa tagccttgtt gaacaggaga 3190921 ctgcacctgt tggacaggag agccgccagc tgagcgcctc cgctgtcaag tcgctatccg 3190981 acattgccaa gtggggcaaa atttctggca tcttgttaat cattatggga tcgcttgtca 3191041 ctctgtctgt tttgatgaca gtgattggcg ccatcccggg cgtactgctc attatttcag 3191101 gcgtattttt gatgcgctca gcaaaagcag ccgcggaagc cgaaggaaat ctaaccggca 3191161 gcgctggcga aagcatgctt gaaaattacg ggacatttat aaaaatgcag ctgttttatg 3191221 cagcatccag tatcgttact gtcctgatcg ggatcattgt agccattttc gtgctggtgg 3191281 taatcggcat tgctgctttt gagaacacgc cttcgtatga tgatccggat tcttattatt 3191341 atgaggatga tccggtgttt gaataatgat gagacaggac agggcatgag ttccatataa 3191401 acggaaccat gcctatttta tttgactatt caaagcaggc cggcgtaaac accaaatcct 3191461 gaagcaagca tacaatagac atctctagta gaggaaatca acaaagcaac gctgttaccc 3191521 agaaatgaat atcaaaaaaa cggatgaagt cggaatcaat ccgaaaccgc actttttatt 3191581 tcgggtgtct gcatgcaaaa aaacacaccc ggatcgtctg gaaaatctca acaatccggg 3191641 tgcagatctt ctttaataca tttttttgcg tctgtcttcc tcagtcaaaa attcaacaaa 3191701 actccgcatc gcaaaaggct cttcctttat ttgtcgtgcg taggagcttt tccgctcttc 3191761 tgaaaggatt tcgctctttt tgatcctgtt cagcatatag atgtgaaccg ttttttggat 3191821 ttgtttatgc tgatagcctg cctctttaaa aaatgcgagc ccgagcgccg ccaaaagggc 3191881 gaatatgcct gcgctgatca gggactccct gtcagctgaa gcatgaaata gaaaagcagc 3191941 taaattaaag agagagaatg cagcaagcgg aatagcaaga aaacggtaaa tgacggtttt 3192001 tttcatgaaa ggctgtacgg ccttttgaat tttttgcatt tctgttttga tgaaccccgg 3192061 catttgttcg actctgtaaa agttcatata atcctccccc tttatttgat gtttcaagct 3192121 tcacgaacgt tatcatatgt gtttatttta acgcaggtgc aagctggttt taaagaaatc 3192181 tgcccgtatt tttcacgaag aatctggatc gccgctcttt attcttttaa aatgtgagtg 3192241 ttataatttg taatgggaat cagatcactg ttattcatgg aatactaatg gcaatcttct 3192301 tgataaatat gaatgagcgg ggttacaaag tgagtatttc ttccatcctt ttatcacttt 3192361 ttttcatttt aaatattctt ttggccatca ttgtcatctt caaagaacgg cgcgatgcca 3192421 gtgcatcttg ggcgtggctg cttgttcttt tctttattcc cgttttaggc tttattttat 3192481 acttattatt cggccataat ctcagacgca agcatttgtt tcaatgggaa gaccggaaaa 3192541 agattggaat tgaaaggctg ctgaagcatc agcttgaaga tttagaaacc aagcaatttc 3192601 agtttaacaa ccgggcaacc tttgataaca aagatttaat ttatatgctg attatgaata 3192661 accatgctgt gtttacagag gataattcag ttgacgtcat tacagatgga cgggataaat 3192721 ttcagcggct gctgagtgac atttcaaagg ctaaggatca tatccattta cagtattata 3192781 tttataaagg cgatgaatta ggcaaaaaat tgcgggacgc tctcatccaa aaggcgaaag 3192841 aaggtgttca ggtcagagtg ctttatgatg aactcgggtc cagaacgctg agaaaaaagt 3192901 tttttaaaga gcttcgcgag gctggcgggc atgtggaggt ctttttcccg tcaaagctca 3192961 ggccgattaa cctgcggctg aattaccgga accatcgaaa gcttgtgatc atagacggta 3193021 tgaccggtta tgtcggaggc tttaacgtcg gagatgagta tctagggctt aatccgaaat 3193081 tcggttattg gcgggatacg catatccggc tgcaaggaac ggccgtgcac gccatccaaa 3193141 cacgattcat ccttgactgg aaccaagctt ctcatcacca tacgctgaca tatattccaa 3193201 atcactttcc tgattacggc ccaaaaggca acgtcgggat gcagattgtc acaagcggcc 3193261 ctgattcgga atgggaacaa attaaaaatg gctacatcaa aatgatttcg aacgccaagc 3193321 gttccatttt gatacaaaca ccttatttta tcccagatgc aagcctgctg gatgctttaa 3193381 ggatcgcttg cctttcgggc attgacgtta acattatgat tccgaacaag cccgatcacg 3193441 cctttgtata ctgggcgaca ctttcgtata tcggcgatct gctgaaagcc ggagccactg 3193501 tctatattta cgataacggc tttattcacg cgaaaaccat cgtggtggat gacgaaatcg 3193561 cttcagtcgg cacagcgaac attgatgtcc gaagcttcag gctgaatttt gaggttaatg 3193621 catttattta cgatatcacc attgctaaaa aactggtttc aacttttaaa gaagatttgc 3193681 tagtatccag aaaattcacc tatgaggagt atctgcagcg cccgttgtgg attcgaataa 3193741 aagaatccgt ctcgcggctg ttgtcgccga tcttataaga tgcgtaaacc cccggccttt 3193801 acggccgggg gttttcctga tggtcacagt aaatgatgat tgcctcccgc aaaaaagcgg 3193861 caagaccttc tccatattga ttgattgaat cggtaaatcg ctcgtcagtg atatacactt 3193921 ccccgagtcc tctgaaaatg tcgagtgtgc aatcgtaatg atattggcaa atatgatcgc 3193981 gaaatgcccc cacagcggcc tgaatctctg catcatcggg cccatgcttc attcgcgccg 3194041 caattcgtct gtaaatcgaa tcaaattcag ccatgatcgt gcgccaatca tctgccgagt 3194101 atgcagatgt ccttttctct gtttcttctg cgatttcctt tccatacagc tttctgactt 3194161 catcagcgta tgtctgctgg tgctcttcaa tgtctttcat gcttaatccg gcaaataaat 3194221 ccctcttatt catcgtttcc cctccatcaa cggacaaaag cgtcctgtca attgtttgaa 3194281 tcatctcatc cattctttgt tttttcttca tcaatatctc cttttgcgac tgaagtgccg 3194341 ctttccggtc aaaattcgga tgatccagca tctctttaat ctcatccaga cgaaacccga 3194401 tttccttgaa aaataaaatc tgttgcagtc tttccaggtc tgcgtcactg tacaaacgat 3194461 acccagcatc agtaagcgct gaaggattca gaagctcaat attgtcatag tgatgaagcg 3194521 tccgaatgct aacgcctgat atctccgcca cttgtttaac ttgatatttc atacataaca 3194581 cctcctcttt tttatcgtaa acaatcacgc aacgttaggg tcaatcccca aaatgttatt 3194641 ttctatatac aaaacttctc acaaatagtg tataaaagaa aagtgagtat ttttttgtaa 3194701 aggggagcca gtatacatga atcctgaaac aatgaacaaa accctcatca gcatttcgaa 3194761 atggggaaaa gctacaggca ttttatttat tattatgggc gcaattaccg cgctttcagg 3194821 cgcgttcttt tttctaatcg gtgccgtgcc aggcgtactg caaattattt ccggtatctt 3194881 tttgatgagg tcagctaggg aagcaggcca aatggctgaa cacaatagcg gacagtctga 3194941 agacttaatg ctggagaatt acgcgaaatt cgtaaagatg caagggattt atttgatcgt 3195001 aagcattgct gtatccattc ttgcgattat cgccttcttc atctttttaa tgcttgggat 3195061 tgctgacggc cttttcagcg atacgtacag cacttattaa tgagaaaaac ccggagctgg 3195121 ctccgggttt tttattattc cgcttcgctt accactgtga agcgttcatt tttgtgttcg 3195181 ggatgttcaa gctcgtccaa cacggcaatg gcataatctg catagctgat atagctgtct 3195241 ccttttgcat ttacgatgac attgtctttt cctttttggt aagagccagt ccgttttcct 3195301 gctggatcaa aaaatgccgc aggactgagg aacgtccagg aaatggagtc tgtctgctgc 3195361 aaatctttca ggttctcgcc ttgatttgat gcagttggca aatattcttt cggaaattcc 3195421 ggcgtatcca ttaaacgggt tgttttggct tcatcaacaa acaggcttcc cgctccgcca 3195481 acaacaagca atcttgtgtg cttcgcgtcc tttaaaatgc tgatgagtgc tcttcctgct 3195541 tcaacatgaa gatgttcttg gccgggtgct gctccaaaag cgtttacgac cgcgtcgaaa 3195601 ggcttgatgt cttccgcagt cagttcaaac acatcttttt ccaaaatcgc tacgtcttgc 3195661 tcctgcactt ttgaagcgtt tctgacgatg gctgtcactt catggcctct ttttttcgct 3195721 tctttcaaaa tctcgtttcc cgctttcccg cttgcgccta taataccaat tttcattttt 3195781 catttcctcc ttatttgtaa caattttagt tacatgttag cggtgagaag tcatcccttt 3195841 tgattaaaag agatgattca taacatcttt taatgacttg cttgccagtt cattttccat 3195901 cgctctttgc acactttcaa acgtttcatc cagagcgttc tgaatttttt tccctaccgg 3195961 acatttcgga ttcgggtttt catgaaccgc aaagagttct tcttgctttt ggacagcccg 3196021 gtacacttct aaaagagaaa tatcagcagg atcttttttg aggcttgcac ccggcacccc 3196081 ggcgcgtgat gtgagaatat cagctttttt cagcaggctg atcattcttc gcacaactac 3196141 cggattcgtg ttgacactgt ctgcaatgat ttctgaagat gttttttcat ccatcgagat 3196201 gagggataaa atatgaatgg caacagcaag acggctgtta atcatgtttt ttcaccaccg 3196261 ttgtaactat aatagttaca tttgattcgt ttgtcaacat ctaatataca ctaaatacat 3196321 gggttttgtg caccgttttt agtcaataga acggccggat gcactccggc cgcgtcttat 3196381 caaaataaga aatatctttg tccaagtggg acataatcga caggctggca agacaattcc 3196441 tccccgtcag caaagacctg ataggttttt ggatcaatct caatcttcgg caaagccgaa 3196501 ttcagcttca tatccagctt gctcagcttt ctgatatttt tgactggaga aatccttttt 3196561 tccagcccta agctttccgc cacaccacgc tctatgcttg cctgagacat aaatgtaatc 3196621 gaggttgagc ggttggcttt tccgtaagac gcatacattt ggcgcatgaa aaccggttca 3196681 ggagtcggga tggacgcgtt cggatctccc atttgcgcac gtgcaatcat gccgcccttt 3196741 aagaccagtt ccggtttcac gccgaaaaat accgggtccc acagaacgag atcagcaagc 3196801 ttcccttttt ccaccgagcc gacctcatgg ctgagcccgt gcgtaattgc cggattaatc 3196861 gtgtatttgg caatgtaccg ttttgcgcgc acattgtcat tcccgttttc accggcaaga 3196921 gcgccgcgct gttttttcat tttatcggct acctgccatg ttcggatgat cacttcaccg 3196981 acccgcccca tcgcttggga atccgatgat gtcatgctga tcgcacctat atcatggaga 3197041 atatcctccg cggcaatcgt cgccgccctg attctggaat ggctgaatgc cacatcttca 3197101 ggcactttcg catctaaatg gtggcagacc atcatcatgt caagatgctc atccatcgta 3197161 ttaacggtat aaggaatggt tggcgttgta gatgacggca gaatgttcgc gtaagaggcg 3197221 agcttcataa tatccggagc gtgaccgccg cctgcccctt caatgtgata agtatgaata 3197281 acccggtccc cgatcgcgtc gagcgtgttt tccaaaaagc ccgcttcgtt aatcgtatcg 3197341 gtatggatgg caacttgaat atcagcctcg tccacgactt ccatacacgt tttaatggcg 3197401 cttggcgtcg ttccccagtc ttcatggagc ttaagaccga tggcgcctgc ttccacctgc 3197461 tcgatcagcg gcgctttatc ggatgcattc ccttttccta agaagccgac attgatcgga 3197521 aactcctcgg ccgcttccag catcctcgcc atataccacg ccccggacgt acatgttgtc 3197581 gctttgcttc ctgtagcggg tcctgttccg cctcccaaaa gggtcgtcac acctgaagaa 3197641 agcgcaactt ccatctgctg aggacaaata aaatgaatgt gcgtgtccac tcccccggct 3197701 gttaaaattt tgccttcacc ggaaatcacc tctgtccccg ctccgatgac catgtgcgga 3197761 tcgactccat ccatgatatc aggatttccg ctttttccga caccgacaat ccggccgtct 3197821 ttcacaccga catccgcttt gacaatgcct gtgtaatcca atagcacgac gttggtgata 3197881 accaaatcca aagcgccgtc cttccctgtg attctgccgt tttggcccat gccgtctcgg 3197941 atagtttttc cgccgccaaa gatcatttct tcaccgtata ctgtgaaatc cttttcgact 3198001 tcgatccata aatccgtgtc gcccaatctg attttatcgc ccgttgtcgg gccaaacagt 3198061 tccgcatatt cctcccgtga cattttcatc ggattacacc ctccatccag ccggcttgtt 3198121 ttaagttggc caacgttttt tctttgccgc gttcatcgat aaacgtgtcg gccattccgt 3198181 tcagccctct aattgtcttg cgtcctctga tttccactag tgagaccgtt ttctgctctc 3198241 ccggctcaaa acggaccgac gtgcctgatg gaacatcaag acgcatgccg atcgccagct 3198301 cacggtcaaa taataaagcc ccgttggcct ccgcaaaatg aaaatgcgaa ccgacttgaa 3198361 tggagcgtga tccggtgttt tttaccgtta cctcccgtat ctcacggcct tcattaatcg 3198421 taatggttcc ctcagcaatt tgaaatgctc ccggcttcat gacttcacct ccgcagaaat 3198481 tggctgatgt accgtaacaa gctttacacc atccggaaat gtggcctcca cctgaatgct 3198541 gtccagcatc tcaggcacac cctccatcac atctttttcc gttaatacat ggcggccggc 3198601 ttccatcagc tctgctactc ccttcccatc acgtgcgcct tccataataa agcaggtgat 3198661 ataagcagca gcctcaggat agttcagcag aacgccccgc gcctttcgct gtttggctaa 3198721 ttcccccgct gcaaaaatga gcaatttctc ttgttcaact ggtgtcagtt tcatctgtag 3198781 tcctccttct tttgtcatat aaagcagatg cggctactac gaatttgcgg aacagtcagg 3198841 cgggacatca cctccctttc ttcgagaatg ggggtcatac ggtaagatgc ctttcaaagc 3198901 ggcatgccgt ttcttcatca gccttgccat ggtcaacaac cgttcccctg tcgatcacgg 3198961 aaagatcaga ttaacgcgtt ttccagactg cgctcgacta agataacaaa tgtctttttt 3199021 tctggaaatt tctataataa cttgtctgac tagttcgaca attaaaatct gaattccttc 3199081 caattgttta ttaagtaaaa tatttttcag atttaccatc agcgctctgg tgattgcaag 3199141 ctgctgctgt tgaccgcctt ttcgttttga acaaacgttt gattaaaaca aatagccccc 3199201 tctgtttagc cggagtcggc ctaatacagc gacaatctgc cccgggcgaa gctaaggctg 3199261 tgcaaaacca tcgattgatc ataaccagac gttacattcc tgatggcagc ccgttgtttt 3199321 gctccgcaac cggaagcatg gcatggaggc cagtctgagg cgccgacctc cacgataccg 3199381 agaacccgac tattgccatt aactccgcat catggacggt cacttcgctg atcgccaccg 3199441 ttcctcttaa tgagtgaaga attccggcct tcactgaatc cccgcttgtg tcgatatcaa 3199501 ctgttttctc gcactcccgt ggcttccgac actttcttcg gtgcagtaca ttccgtcatc 3199561 aaaacccctt tgtttgattt cttcaaatga tgttataaaa gtttacaact tatgtcatca 3199621 ttatatagaa gaggcctatt aattcaaaga atatttaaaa aatttagtta ccttgaccaa 3199681 atcagcttct ttttttgtta tatttattca catcagaaaa agcgaaaaaa aaagacaaga 3199741 aacatttcgt ttcctgcctc ttccgtacga ttaatcttta tctgaaaatt tatccttggc 3199801 tttcccgata tccttttgga tttcgccttt tgccttatct tttttgcctt cagcctgcat 3199861 gtccgttctg tcagccatat ctccgacttt atccttcact tctcctttgg ctttattgaa 3199921 gccgcccttc attttgtctt ttacactatc gttacccatg ttaattctcc cctctcaatt 3199981 atgtgtgtac ttgttaactt cccgatctga gaggcaataa acattctaat gttatttatc 3200041 gatttcgtag cgctctccgt aacggagcac cttgtatatc gccagcccgt ctgatgactt 3200101 tttctccgaa tatcggaccg gcagcagggc aaaaaacaca taatacgtag aaaaatagac 3200161 aaactgatag aaaaacacat tcggctttaa tacactgtgt ataatcagca gattgattgc 3200221 aaaaatcgtg atgaggttaa acaagcagcc ccctgcatac acgagtgcat ttgagaatcg 3200281 attgtcaatt ttcaactccc cgtaccggca aaaagaatcg ataaaataaa tcgttctgaa 3200341 ccgtatgggt ccaattttaa gcagcgtttt tcccatgcct atatccaacg atccctttcc 3200401 gccaaaaata aaagccataa agctgtgccc tgaaacatgt ataatctgta caagcggcag 3200461 aacaatgagg aaagaccaca gaaacttcac catatcatta aaaccaaaca ttgaattccc 3200521 cctcacatgc atatctgcat cccaaaacgg cttttgttca aaaaacagtg ctgtagcgat 3200581 ttttcctgtt ctccccggaa ataaacgttc cgatgctccc ctttttttgc ataaaaaaaa 3200641 accatctgcc agcagatggt tttgtctcat acttcatata aacaatcgtt cctttgaatc 3200701 atctctctca tgctgaccgc tttttcataa aaatacaccg cttctttata ttgttcgcga 3200761 tgactgaaat aagaggcagc atctaaagca aattcttcaa tatatacata caggcccttt 3200821 tcttccatat aatcaaatac ttcttgaatc atattcaaat tgacagattc cacatataat 3200881 gcctgcagaa atttatattt tgccagactg aagaagtcgt ttcgtttttg ggcaatggca 3200941 atcccttttt catagtaccg tatcgcggct tcgctatctt gttttttgaa aagaacgcga 3201001 gtcaggctga agagcgcttt tggaagctgt tccagctgat aatcctcgaa gacaggaagc 3201061 gctttttcaa agtattcggc ggcctgatcc agctccccct tgtcatcata gcaattacca 3201121 atattataaa gggctgatcc gatcaaacgg ggctgtcctt ccaataaagc aaggcgatac 3201181 gcgtcatcta aatgttcaag cgctttttca taatttctgt agtcaatgta gtttcctgat 3201241 atgacgaaat ggcattgaat tcttctgact ctgtaaaaat cgtgagcctt atacgtctcc 3201301 agcgcctgta cggcatggtt catggaaaag tgcgtctgct tcataatata aaagacttcc 3201361 gccactttaa aatgaaattc cgctctttca atttcatctt ctacaaacgc aagcatcttc 3201421 tcagctttcc gataaaagga tatagccgag atgtaattgt tctgttcaaa ttcgtacatt 3201481 cctctaaaca agtgaaaata atactcagat aatccggaga tgctgtcctg attgctttcc 3201541 agcgttttga tcaattcacg atattgaagc tgagattcct cgtgcaggtc aggctttaca 3201601 taatccagca taatttggtg ccggtagctg atcagctgat aatacaggag aagcagctga 3201661 tcctcttcca tctgttcgat atctagatca atttcttctt tcagttttac ggcatcagcc 3201721 acttgaaatg ctaaaatgtg cttataccac ttattgattt tcactcctac ttgagatgac 3201781 gggatctcgt acgcggccat gcccctccaa ccctttctat tttctaattg gttatatttt 3201841 atcataatgt atggctttgg aattaaattt tcttacaatg attccttctt tatgcctatc 3201901 cttatatatt tcggtttttc tacgtatttt ttgcactcgg attctaataa aaaagcttac 3201961 cggacagtgc cgataagctt ttgacttcaa attaaccgcc aatataagac atttccactt 3202021 tctttttgcc agatgctttt gatagcgtac gatcgactga atactgatcg atccgatttt 3202081 tccatactgt cccgatcatt tctgatagtt cgtcatcact taattcctgg cgaaccggag 3202141 ctctgaggtc aaatccgctt gaagcgaata agcaggtaaa cagctctcct ctcgcagaaa 3202201 gacgggctct gttgcaagat ccgcagaatg catcagatac agatgatatg acgccaattt 3202261 ctccggagcc gtccaagtag cggaatctgg aagccacttc gcctatataa ttaggcgcta 3202321 tcggctcaac cggcatgtgt ttattgatca aatctatgat ttccgccttt gtcatgacgt 3202381 ctttcttttc ccattggttg gtgttgccta cgtccataaa ttcaatgaat ctcaggatat 3202441 gccctttttc tttaaaataa cgggccatag gcagtatatc tttttcattg acgccctttt 3202501 gaacgaccat attgatttta acaccgagcc ccgcttgctt cgccgcttca atgccttcca 3202561 gcaccttgct gacagaaaca ccgcgcccgt ttatcttctt aaaacgctcg tcttctaaag 3202621 aatcaaggct gatcgtaacc cttttcagcc cagcctcctt gagcctctta gcataaacag 3202681 gcagcagtga tccgtttgtc gtcatcgcga tgtcacgaat acccggtatg cgggccagtt 3202741 ttttgattaa ttccggcata tcctttctca tgaggggctc tccgccggtc aagcggattt 3202801 tttcaacgcc aaatcttgtg acaaacaatg tcgcaagccg ttccagctcc tcaaatgaaa 3202861 gcagctcctc tttctttaaa aaaggataat ccgggccgaa taattcggcg ggcatacagt 3202921 acgtgcatcg gaagttgcag cggtctgtaa cagaaatgcg aaggtctctc agcggtctgt 3202981 ttcttttatc caacatctga cgcgactctg taatcatagc tacagcccct tcctactccc 3203041 tgattctctc agggtgtgta tatacattaa atgatccgtt tctgacaaat ccaatcgctg 3203101 tgatattcaa ttcttcagcc atttgaatcg caagctccgt cggggccgat ttggaaatga 3203161 caatcgacac gccgattttg gccgctttta acaggacctc tgatgagatt ctgccgctga 3203221 acacaatcag tttgtcgcgt acggacatcc cgtttagaag gcagtgtccg tatagtttat 3203281 caagtgcgtt gtgccgaccg atatctgtgc gcatcaacag aagcttctct gtgtcgcaaa 3203341 gcgccgcatt atggacgcct cccgtatcct gaaacgtccc gctcccttgc tgcatgtctt 3203401 tcataagcgc cagacatgcc tcaggcgata tcttgatttg gctgacagcc gtcttggctg 3203461 ttttgacatc ctgctgaaaa taaaaatgac ggccctttcc gcagcatgag ccgatcaccc 3203521 gtttcgtata atccttttga tccaatgtct cagggtgaac gaggtcgaca tatacaaaac 3203581 cgagactttc atctattgta aaccttttaa tttctttttg aaatcgtata acaccctctg 3203641 atgcgagaaa tccgatgaca agctcttcga tatgctcagg cgtacaaacg agcgtcacaa 3203701 attcactgcc attcagtatc actgtcaaag ggaattccgt caccatccgg tcttctactt 3203761 tgcttatttc cccttgttca tagcgccata catccctgac cgcagttact ttatcgttca 3203821 atgtctcttc ccctccgcaa tgttcctgcc tttatatttt ttcacactcc tcggattttg 3203881 tcgaattctg agacacaaaa agagccctct atataaaggg cttttacagg atgtgatgac 3203941 ggcggtgttt aggcaggacg cctaagcatt tagccgccgt tccttttata acacgtgagc 3204001 accaatgtgc attgacaacg aacgcggggt ttgtcgacac gctgagacac ctctgtataa 3204061 aggactctat gtttgattat gctgattctt tttcagaacc gtaaacagca caatagctgc 3204121 gatcaaggtg agaatgctga caaaaaagaa ggctgccagt tttagaagaa caccaagcaa 3204181 tataaatgca acggtggcta taagaaaaat cattccgaat aatttcatat gttcaacccc 3204241 tttttagggt atcattcccg cccaaactgt ttttaaacca ataaaaaagg cgcctggggg 3204301 agcgcctgat ctttaggttc cttactcagt aaatttttgt gcttcttttt cccaagcctg 3204361 ttcgaactca tccgcactgt tcgctgaaat atattctccg ccgccagcga cagctgcttg 3204421 tttcatctct tcattaccct tgacatcaaa gttgaagcca atgatgttta caatcgtatc 3204481 cacatttgat gcacggagct tttcgatttc cgccgcaggg tctccgccgc acgtttcttc 3204541 accgtcagtg attaaataca ccacgttttt cccgtctgcg tcaaatgctt caaattcttt 3204601 tcttgtgtct gcaagtgctt tggcaatcgg tgtccatcca gtcggcttga gctcactcaa 3204661 tgaattgtca aacagagacc cttcatatgg atgaaggccg taaatggttt ccgtcgtact 3204721 gcacgaaagg gctttaccgg acagtttatt gttccctgca tgcccgaaaa cgcgaagcat 3204781 aagatttgta tcctttggaa gaagttcggc aaaagatttt actgattttt tggcaatgtc 3204841 tattttgcgc tctcctcctg ttttttgaac catgcttccg cttccgtcaa acaaaacagc 3204901 tacatttgta tcagcctgtt tctcagcggc aaaagacggg gaggcaatgg aaacagtcaa 3204961 caatccaatg ataccggcag ccagcaattt tttcatatga ttacttcctt tctttttcat 3205021 attttccaac tatatgttgg attcttcttt atgctagaat acgaaaatgc aaaaagatat 3205081 aggacatgct gccttttgtg ctgctttcac gatctgtcca aaatcgcttg aaatgccgtt 3205141 catttttagc catttccgcc cagaaagcat aaacagcttg tgtgatcatt cattcttttt 3205201 tcgccttgat tatgacagaa aaacggaaat ctgctactat gctacaggca gacagctaat 3205261 tagttttgaa gtttttgtta catacaaaaa gaggctgacc atcaccagcc tcttttttct 3205321 tatttagata acattagtga ttgctgagtg aaaattttct caacatcttt ttgggtataa 3205381 gccgggaagt attcaccgcc gcctactttc gcaattgcgt tcagctggcc tttgtatccc 3205441 tctttataat caaagccgat cacattaaca gtgatattgt ctttttgcag ttcctttgct 3205501 gttttaatcg ggtttcctcc gcacgtttcc tcaccgtctg tcaacagata caccactttt 3205561 tccccttttg catcaagctg gtcaaaagaa gatttcgcct cgttcagcgc tttggcaatt 3205621 ggcgtccagc cagtcggccc aattgtattg agagaattga ggaagctttg ctcgttaaag 3205681 ctttggaagc cgtatacgtt gcgaatggct tcacatgact gaacttttcc ggaattttta 3205741 ttgtttcctt cagagccaaa cacgctcatt ttcacctgag ttccttctgg caatgagctc 3205801 gcaaactttg aaatttcttt tttggctgaa ttaaatttag atacaccatc tattcttttc 3205861 gccatacttc cgctggcatc aagcaagacc gccacgttcg ccggcgcttt agcctccgtt 3205921 tctgtctttt cagctgcaaa agcaggtgaa gttaatccaa aaagcaatcc tgtcatcatg 3205981 atcagtgaaa atcttttctt catgttcgta cccctttacc aatttgtttc tgcgtgcaga 3206041 tgttcaacgc tgaacataat ctatcgtaat caacaaaaac cgagaaataa atagggcggg 3206101 cttccccatt gctgttgttt acttttgcat agaaacctat gtttttatta gtgatttcca 3206161 cctaacgccc ctatgaaaag agaagattgt ccgcctttcg gctttcgtta tatgagtctg 3206221 tcgaagtctg tcgacaaatg tggatgactt taccacaatc tcaaagcctg aaatcaggaa 3206281 aaaaggactg atccttaaag acggtcagaa gctcctctaa accgtttcag ctactcttag 3206341 ataaaagata ttcaggaaca gaaaaagacg cccaatgagc gtctttttct actttttcgc 3206401 catatattta ttcaaaaacg catctgcctc agaaatttgt gtgccttggt aatagtactt 3206461 tacaatgtca tcaaccgttt tgccttcttt ggccataaaa ttcgctccgt attggctcat 3206521 ccccacaccg tggccaaatc ctctcgtcgt gactgtaatt gtgtctccat ttcgcttcca 3206581 ttcaaaatcg gcggagttga gacccaactt ttcacgtatg tctcttcctt tcagcgtctt 3206641 gccgttaatg acggcagttg cgacctggtg gcccggtgtc tcgccggtaa tcttccctac 3206701 tgcgctagat ccatccagct tgacgccaag cttttgctga aattctgccg ctgtaaaggt 3206761 tttcgttgcc ttatatttcg gagacttttt atcccatggg cttttgacgc tttttaaata 3206821 tgggatagca cttgtccaat aagcttctgc attctctgtg tagccgttgc ttgtggagaa 3206881 aaaggatgct tcaatcggct ggttgttgta cgttaagatt ttgccttgcg tactggctac 3206941 cgcatctgtg attttcttca gttttgtctc atagcttgtg ccccactgtt ttttcagctc 3207001 cgctttgctt ttatacacct ggaacatctg tgtatcatcc accagtgagc ctttaggagc 3207061 ttctaccgct gaatttgaca ccatcagtct gacaataaat gttctggcgg caagcgcctg 3207121 ggctttcagc gcttcaggtt taaaggttgc cggcatttcg gaggcgacga ctccaatcac 3207181 atactcttca agcggaatgt tttctacgga ttgatttgcg gttcgataga cgggaataga 3207241 aacaggtgat gctttcaatg tttctgctcc tttcgatgct ggtttcgtgc tgactgctgt 3207301 cttttctgat tctacgctgg cccccgcttc cttattatgc tggaatggta taaccaagag 3207361 tgtgggaacc aagagaatca atgcacatag tacggatagt gtgattgcga attgtttcat 3207421 attcagctgc ctcctgctcg ggattcgact ctagtctagt ctatgggcag ggacaagcta 3207481 atatgactct cgttttggac agaaacttta tttgtcattt acgtattctt ttttgctatt 3207541 ttgcgcataa tgatgataat acacaaaaaa taaaaaacca gtatgccaga gtgacatact 3207601 gattttcaag taagtttatg catttaagtc agaaacgact tctttattct cttgctcaga 3207661 agcagactca tcatttacac gttcgatgtc tgcgcccaga gcggcaagct tctgatggaa 3207721 atcaacgtaa ccgcggtcta agtgcttcaa ttcagtaaca cgtgtgtgac cttcagccac 3207781 taaccccgca agaatcagcg ctgcacctgc acgcaaatca gtcgctgcaa cttcagctcc 3207841 ctgaagctgt acaggaccgt taatgatgac agaacgtcct tcaatcttga tatcaccatt 3207901 catacggcgg aattcttccg catgcataaa acggttttca aaaacggttt ctgtaatcat 3207961 gcttgtgccg cttgcacgaa gcagaagcgc catcatttgt gactgcatat cagtcgggaa 3208021 gcccgggtga ggcattgttt tgatgtcaat cggtttaagc tctttcgggc cgatgacacg 3208081 cagaccttca ccttcatcct taattgttac acccatctct tccatttttg caattaaaga 3208141 ggtgaggtgc tcaggaaccg ctccttttac taatacgttt ccttcagtga ttgcagcagc 3208201 aaccataaat gtgcccgctt caatacggtc aggaataata tggtgtttta cgccgtgaag 3208261 cttttcgact ccttcaattt tgatggtgcc ggtgccagct ccgcggattt ttccgcccat 3208321 gccgttgata tagtttgcta aatcaacgat ttcgggttct tttgccacgt tttccagcgt 3208381 tgttgttcct tcagctagag cggctgccat aatcaggttc tctgtagctc ctacacttgg 3208441 gaagtccaga taaatttttg cgccttgcag tcggcctttt acttcagctt caatgaagcc 3208501 attaccgact ttgatttctg cgcccattgc ttcaaaacct tttaaatgct gatcaatcgg 3208561 tctggaacca attgcgcatc cgcccggaag tgcaactctt gcatgacctg tacgcgcaag 3208621 aagcggcccc atgacaagca cagacgcacg cattttacga acatattcaa aaggtgcttc 3208681 agtttgcaaa gcgtatgaag catttacagt cacttcatta ttttcaaaat gcacatctgc 3208741 tcctaaatga cgcaacactt cgttaattgt atatacatcg gagagcgtag gtacatcaca 3208801 aattacgctt ttttcttcac ttgctaataa agatgcagcg ataacaggta aaacggcatt 3208861 tttagcgcct tcaactttga ctgtgccgtt taacttctga ccgccgcgga cgatgatttt 3208921 ttccaaggta ttcccctccg cgtccctaaa ttctctatat taatattcag tcgtaacgat 3208981 tggtgtgcca accgtaacgg tatgttttcc gcccattcct gcacttctaa gtgcaatttg 3209041 caaattcatt ttatgtttcg aggtcataat gtactcttcc cactcatctg taaacgcaga 3209101 aatagaaacg aaatttggct caactacatg ttctactgat cttgcttgaa attcatttaa 3209161 taactgattt gctttttttt gcaaaacaat attcatatta tcatctaagt gaccatttag 3209221 acaagtaaaa ataactactt tttcttggaa tatcccaagt gtctcccgtt caaactgttc 3209281 atatgtatca ttccagctat ccggtgtctc tagactcatt tgctcatata ataaatacga 3209341 agttggattg tgttttttga gggttgtgac aagctgcagt ctaaaagaag tacgattttt 3209401 tttgtcagta tatgtgccaa ttgcctttat cattttatct tcccgtgcaa tcacccaatc 3209461 atattgacga tactcttgtt ttaaacgttg cactttttga taaaattctt tttcggtcag 3209521 tgacaagttt tgttttgcat gcaatgtcca cttatctatt gacacatctt gacgttccat 3209581 cccctctgcc atctgtgcta acggcgttaa ttcactcgca tgaatggtat ggaaaacagc 3209641 aatgacgaag cttaacatga cggaaatgat aatagcgtgg cttacttgtt ttttcttcat 3209701 gttcatctct cccccttatc cccagtttta ccggaggcaa gaggcgccat acgtaaaaat 3209761 cttcgtcaaa actcgagcta ttcgcttcaa cccgcttctc ccaaccattt aataatgttc 3209821 aaaacctatt aaaatagata gggaagctgc tgtgaataat tgaggtaatc taaaaagaaa 3209881 ttggcaacgg ccgttccaat ggcgattgtc agcaaaatca tcaggagtct tgcctgcacg 3209941 actttgcctt ttttgattaa cggatctata ttgacggctt gcaacgccca ccaagtcact 3210001 gctataaaaa tcaggtgaac gacaatgccg attgcagcct gctgtcccaa tacactcatc 3210061 tattacactc ctttctctgc gttcataccc tttcttatta tataagaagc acagataaag 3210121 atgatacatt ttatacagaa cggaataatc agccaaatct agggctaatc cccgcttaaa 3210181 gtgcgattct tttacatggt atactttatt ggaaaggagc tggcaaatgt gaatcattct 3210241 ttttttcagc ctgaaaagca atatggtgag gacctgccaa tttttgatca ggaatgggaa 3210301 gcaattgcat tctattatga ttatagacag tcacagattg aagaactgaa tgaattgtgt 3210361 cagtttttta acatttctct tacctatacg agagaaagcc ttgaagagct tgaaaacctc 3210421 tattttcaaa gtatacaaga acttttgctt gctgattgga atcttcctat tgaagaattc 3210481 gagaaaatga tcagtgttta tcttatagat tgtgtgattg cccgccatga agatgctgaa 3210541 tgggttgtaa aaccttatcc ctataaagac ggcgcttata cacttggctt tagaagacat 3210601 cgcaaatcgt ggcatacaat gaatgcctgt gatggtttat acctgcgtcc aaaagaggat 3210661 cgcccgttgc tgtcgctgtt tgattctctt gtgcgttcat aaaaaaatcc ttctcataaa 3210721 gagaaggatt ttttcttatt tccctgctac atccaatctg ttcaaagccc gctgtaacgc 3210781 aagctcagcc cgacgaatgt cagtatcatc tgattgagaa ttcaaacgct cctgcgcccg 3210841 ctggcgtgca gcttcagcgc gctctttatc gatgccttcc gctgtctcgg cagcctgggc 3210901 aaggatggtg acatgatcag gacggacttc tacaaaaccg ccgctgacgg caaccatttc 3210961 agtctgcccg tcttttttca gacggacagc gccgatttta agaggagcca cggttggaat 3211021 atggcctggc aaaataccga gatcgccgct ttcggctctc acactcacca tttcgatatc 3211081 cgcatcgtat actgggccgt cgggagtaac gatattgact ttaacggtct tcatgctttt 3211141 accctcctag gaccagatta aacttctaca cccatttctt ttgctttctc aacaacttct 3211201 tcgatacggc ctacaagacg gaatgcatct tctggaagat ggtcatattt accggctaag 3211261 atttctttga agccttgtac cgtctctttt acaggcacgt aagaaccttt ttgtccagtg 3211321 aactgttcag ccacgtggaa gttctgagaa aggaagaact ggatacgacg tgcgcggtga 3211381 acgacaagtt tgtcttcctc gcctaattca tccataccga gaatcgcaat gatatcctga 3211441 agctctttgt aacgctgaag cgttgactgt acttcacgcg caaccgcata gtgctcttct 3211501 ccaacaattt caggagcaag ggcgcgtgat gtagatgcca acggatcaac cgcagggtaa 3211561 atacccattt cagttaattt acgctcaagg tttgttgtcg catccaagtg agcgaacgtt 3211621 gtcgccggcg ccgggtcagt gtagtcatcg gcaggcacgt agatcgcctg gatagatgta 3211681 actgatccaa cgttcgtaga cgtgatacgc tcttggagct gacccatctc agttgcaagc 3211741 gtcggctgat aaccaaccgc tgaaggcata cggccaagaa gggctgaaac ctctgaaccc 3211801 gcttgtgtga aacggaaaat gttatcgatg aagaacagta cgtcctgtcc ttgtacatca 3211861 cggaagtgct cagccattgt aaggcctgtc aaagcaacac gcatacgtgc gcccggcggc 3211921 tcgttcattt gtccgaatac catggctgtt ttgttgatta cgccagagtc actcatttcg 3211981 tagaaaaggt cgttcccttc acgagtacgc tctcctacgc cggcgaatac agagataccg 3212041 ccgtgctctt gcgcgatgtt gttgattaat tcctggatta atacggtttt acctacaccg 3212101 gcaccaccga acaatccgat tttaccgccc ttaatgtaag gagcaagcaa atcaacaact 3212161 ttaatacctg tttcaagaat ttcaacttct gttgaaagct gatcgaatga aggcgcctgt 3212221 ctgtgaatcg gatccttttt cgcatccgca ggaaccggct cattcaaatc aatattttct 3212281 ccgagaacgt taaatacacg tccaagtgtt acatcaccaa ccggtactga gattggcgct 3212341 cctgtatcta cagcttccat accgcgctga acaccatctg tagatgccat tgcgattgta 3212401 cggactgtat catcacctaa atgaagagcg acctcaagcg ttaaatcaat acctacttcg 3212461 ttttcacttg cagctggctg tgaaatttta atcgcattat aaatttcagg caagtgaccg 3212521 tcttcaaaac gcacgtcgac gaccggtcct aatacctggc taacgcgtcc tttcttcatc 3212581 gctatccctc ctgacaaaat ctttctattc taaagcggct gctccgccga caatttccgt 3212641 aatttcttgt gtgatggctg cttggcgagc gcggttgtaa gaaagcgaaa gtgaatcgat 3212701 aagttccttc gcgttgtctg tcgcgttttt catcgccgtc attcttgcag cgtgctcact 3212761 tgctttactg tcaagaagcg caccgaagat taagctttct gcatattgag gaagcaaaac 3212821 ctccagaacc tcctcttcag atggttcaaa ttcataagac gccgttcttt ttccgccgcc 3212881 gctgcccaaa tcagataacg gcagaagttt tttctccgtt acttcttgag taatggcgct 3212941 gacaaaatgg ttataaacaa ggtgcaattc atcaaacgca ccgtctataa acatttgaat 3213001 cgtttgacgg gcaagatctt taatttctgt aaacgttact tcatctccaa gtcctgttaa 3213061 ctcggaaatg atcggaatct cccgtttctt aaagaaatca cggcccactc ttccgatggc 3213121 aatcaccgca tactcatcct tagactgatg acgttcttgc atggcctgat aagcactccg 3213181 taaaaccgaa ctgttaaaag cgccggcaag accgcggtca gacgtaatga caaggtatgc 3213241 cgtttttttc acttctctgc tgagaagcat cgggtgcttc acgttgccgg aaactcttcc 3213301 gacgtttgac acaacctctt ggattttatc catatatggc acaaatgatt ttgcattgtt 3213361 ttcagcacga ttcagcttag ccgcagatac catctgcatg gcttttgtaa tctgacttgt 3213421 ttttttcgtt gacgtgatcc ttgacttaat atcgcgtaat gaggccaaag atttcaccac 3213481 cttttctctt catctgcgta aaaagagaga aaaagagaac ctttttctct catcagcatt 3213541 cgagttagtt gcttggtgca aatgtgcgtt tgaagccttc gattgcagct ttgaagtctt 3213601 catcagcagg aaggtttcct gttttcgcaa ttccgtcaag caggtcttta tggttttggt 3213661 caaggtacat gtagtactct tcttcaaaac gtctgatatc cgccacagga atatcatcga 3213721 gatatccttt tgtcagcgca taaagaatag ctacttgctt ttcaaccgga agcggcttgt 3213781 tcagatcctg cttcagcact tcaactgtac gcgcaccgcg gttcagtttt gcctgagtcg 3213841 cttggtcgag gtcagaaccg aattgagcga atgcttccag ctcacggtat gacgcaaggt 3213901 caagacgcaa agtacctgat acttttttca tcgctttgat ttgcgctgag ccgccgacac 3213961 gggatacaga caatccggca ttgatcgctg gacgtacgcc tgagaagaac aaatcagatt 3214021 gcaggaagat ctgtccgtcg gtgatggaaa tgacgttcgt cggaatataa gcagagatat 3214081 ctccggcttg tgtttctacg aacggcagag ctgtaattga tcctgcgcct ttcgcgtcgc 3214141 taagctttgc tgcacgctca agcagacggg aatgaagata gaatacatcc ccagggaacg 3214201 cttcacggcc tggcggacgg cgaagaagca aggacagctc acggtaagcg gccgcttgtt 3214261 tagaaagatc atcgtataca acaagaacgt gcttgccgtt gtacataaat tcttctgcca 3214321 ttgtaacccc agcatacggt gccaggtaca gaagcggtgc cggctgtgac gcagacgccg 3214381 ttacaacaat tgtataatca agcgcgccgt gtttacgcaa tgtttctact acgccgcgga 3214441 ctgttgattc tttttggccg atcgcaacat atacacagat catgtcttgg tctttttggt 3214501 tcaggatcgc atcgatcgca acagatgttt tacctgtttg acggtcaccg atgatcagct 3214561 cacgctggcc gcggccgatt ggaatcagtg catcgatcgc tttgataccg gtttgaagcg 3214621 gttcatgaac ggatttacgg tccataacgc ctggtgcagg gctttcgatc ggacgagttt 3214681 tgcttgtcag aatcgggcct agtccgtcaa ccggctggcc tagcgggttt acaatacggc 3214741 cgattaactc ttcaccaaca ggaacctcca tgatgcggcc tgttcttttt acttcgtctc 3214801 cctcacggat ctcactgaaa ggtcctaaga tgacgatacc tacgtttgat tcctcaaggt 3214861 tttgagccat acccaaaaca ccgtttgaaa attcgacaag ttcaccggcc atacagttgt 3214921 caaggccgtg cacacgtgca ataccgtcac cgacttggat gactgtacct acgtcttgaa 3214981 cttcaatatc agattgataa ttttgtattt gctgttttat cagcgtgcta atctcttcag 3215041 ctttgatgct cacttaggtt tcaccccttc tatcgatttt ccccggctaa ttgacgttca 3215101 atgcgctgaa gcttcccgct tacgctgccg tcataaatcc ggtttccaat gcggacttta 3215161 ataccgccta ttaaatccgt ctgcacttca tttctgattc tcagtgaagc gactccggct 3215221 ttttttgcaa acacttgtga taatggtaac atttctgcat ccgtcagcgg tttcactgaa 3215281 tatacgattg cgtcttctgt ttgacgggcc acatttgcga gtttgataaa ctcatctgtg 3215341 agctcaggga caatcgcggc acgatggcgg tcaatcaaaa gaaaaatcgt attgagtacg 3215401 gactgtgaca aagagccaaa tgcattttga atcagctctt ttttcttcgc agccggcacc 3215461 ttcggatggt tcaacacatc attaagcgct ttttcatttt gaaatacttg ttttacaaca 3215521 attagctctt cttctacttg attcagctga gcggactcat tggctatatc aaaaagagct 3215581 gatgcatatc gtttagagac agctgatcca ctcatcggct ttctcctacc tctttaagat 3215641 agtcctggat caatttctct tgcgcttgtt catccagttc tttttcgatc actttcgacg 3215701 caatcatgac agaaagagac gctacttgct cacggagagc agaaaccgcc tgttcctttt 3215761 ccttcacgat ttcagttctt gctgcttctt tcagacgttc agattctgca cgtgcagcct 3215821 gaataatctc ttctttttgc ttctctccca gtttctttgc gttttcgata agagtttggg 3215881 attcctgtct tgcttctttt aaaagaacgc gctgctcttc aatcagctgc tgcgcttctt 3215941 tatttttttc ttcagcagac gtaatttctc cagcgatgtg gtcttcacgc tgtttcatta 3216001 tgtttaatag cggccctaaa gcgtatttct tcagaagcgc taataagatt aacatagcta 3216061 acagttggaa caggatatct ccgccgttaa acgacaatcc tagttcaagt ggtaattgag 3216121 acatctacta cggcaactcc cttctgcagg tttttctttg ctgatccagc agccgcactt 3216181 gtctcttttc agccggcaag gcgggatgct tatcagacat aaagcaatgg cgaaggttct 3216241 cttggaatga tcttcgccat ttttagttca tataaggctt ttatgcttag ccaaagaacg 3216301 ctaagaatgc gataacgaca gcgataatag gaagggcttc aactaatgcg atacccatga 3216361 acataagagt tctcagttct ttacctgctt ccggctgacg ggcaatcccc tctaccgtac 3216421 gtgaaacaat caaaccgtta ccaatacctg caccaagtgc gcctaaacca attgcaatcg 3216481 cagctgctat taaattcatg aaaaagttcc tcctttaaaa tgttatccgt ttggatataa 3216541 tgttttaatg atcatgactg attttatgag acatgtacac catcgtcagc attgtaaaga 3216601 taaatgcctg gatagcacca ataaataaac tgaatgcttg ccatgccagc atcggcagaa 3216661 tggcaccgat tgtaccgaca agaccgagag ccacgctttg cgaataatgg cttgttgcta 3216721 atcccgcaag caggccgaga agaatctcac cggcgaagat gttaccatac agccgcaaac 3216781 ctagagtcag cgtattcgca aactcttcga tgattttcat cgggagcatg aatggaacag 3216841 gtcttaaata gtctttggaa tattccttga gccctttcat cttcacacca tagtagtggg 3216901 ttaaagcaac aaccatcacg gctagcgtta atgtaatggc aggatcggct gtcggagact 3216961 tccaccagag ctcatgtccg attgtaatag agaacggcag ccccagcata ttcgacacaa 3217021 atatgtacat cagcaatgtg acaccaagtg ccaagaagtt agcccctgtt tttaaatcca 3217081 ttgtactgcc aataatattg cggacgaaat caacaatcca ttccataaag ttctgggctt 3217141 ttccgggacg gatcgaaagc gttcttgtcg tcaatatagc aatcaataaa acaatcacac 3217201 tcgccacagt aatcatcaga atgtttgtca gattaaaagt aagacctaga aattctatag 3217261 ttctgtaacc atgattcaaa gggttttcac ctctcttcca ttgatgaacg tttaagctgg 3217321 ataaaggaat ctatcataat gacagggtat attgtcatta atccaataac tgtacttgcc 3217381 atatgaaagt attcgggatt tttataggca acagccacag caagaatcgc attgcaccac 3217441 cgcgctgcgc tcccgagaga tcgtatggac tttcctttct ctacagctct gtcaaaagca 3217501 ttcattcttc tgacgagcag taaaaaatta aacaaactga aaacagttcc cagaataagg 3217561 cctaaaaaaa cggttttata cgctgttaaa ccataaccca gtacatacac tgccaaaatg 3217621 aacaataaat atttgcgttg tctgctaaat gtaagcttgg gatcgtccat caattatctg 3217681 tctcctgatg aaaaaataat gtatagcttg gatacggcaa aaatcagcgg ttaaccctta 3217741 gtagaagacc ttttttgacc ggcaaaacgg gcctgttcga aaaaatcatt catccgcaag 3217801 ccttgcaggg atgctgtttc attcgcttaa ataaatcctc ataatacggg tttgctgaga 3217861 ggatttacat tgaggatgag gactataatg aaagctatga aaaccttctc ataataccct 3217921 cgtttagcat acaatagccc ctaacatgtg tcaatctgtt taaagttaaa aaacttttta 3217981 tactttacgt ctccacagaa tgttcacatt ttcacctata attgtataca gattcaccga 3218041 atagcaaaaa actggataaa aaaatgaaac ccccttttgg ggatttcatt ttttattttg 3218101 ttccaaacat gcggtcaccc gcatctccga gacctggaac aatatatcct ttttcattta 3218161 atttttcatc tagcgccgca atgtaaatat caacgtccga atgatgcttc tgcaattctt 3218221 ccacaccctc cggcgctgct acaagacaca tgaaacggat atttttcgca ccgcgttttt 3218281 taaggctgtg aatggcttca actgcggaac cgcctgtagc gagcatcggg tcaaccacga 3218341 tgaattcacg ctcttccaca tcagaaggaa gcttgacata gtattccacg ggttttaagg 3218401 tttctggatc acggtaaagg ccgacatgtc ccacttttgc cgcaggaatc agctttaaaa 3218461 tgccgtcaac cattcccaat cctgctctga ggataggaac cactccgagt tttttccctg 3218521 agatgacttt cgatttcgca gcctgaaccg gtgtattgat atccacttct tccagaggaa 3218581 gatcgcgggt aatttcaaat gccatgagtg tagccacttc atctactaac tctctaaaat 3218641 ccttcgtacc tgtattttca ttccgtatat atgtcagctt gtgctgaatt aaaggatgat 3218701 caaatacata aacctttccc atactgtgtt tcagctcctt ttttattgtc ccatcaacaa 3218761 ttacacactt ctattgattc tacaaaaaaa gacattgagt ttcaagaaca tcgtcaaaaa 3218821 acccgccggg cataagccca agcgggtttt aggatcttaa taatctaatt ctttatataa 3218881 aggaaattta tcagtcagag cagctacacg ctgtcttgct tcttcaagtt ttccttcatc 3218941 ttcgtggttt ttcaatgcaa gcgcaatgat agcaccgact tcttctaatg cgtctccgtc 3219001 aaaaccgcgg ctggttacag cagctgtacc aagacggatg ccgcttgtta cgaaaggttt 3219061 ttcaggatca tatggaatcg cgtttttgtt agacgtaata ccaatttcat caagtacatg 3219121 ctccgcaacc ttaccagtca gtccgagcga acgaaggtca acaaggataa ggtggttgtc 3219181 tgttccgcct gaaacgagct ggatgccctc tttcgttaag gcttcagcca gacgtttcgc 3219241 gtttgaaatg acgttttgtg catatgtttt gaaatcgtcc tgcaatactt caccgaatga 3219301 aacagctttt gcggcaataa cgtgcatcag agggccgcct tgaattccag ggaagatcga 3219361 tttatcaatt ttcttgccaa actcttcacg gcaaaggatc ataccgccgc gaggaccgcg 3219421 aagtgtttta tgtgttgttg ttgtaacgaa atcagcgtaa ggaaccgggt ttggatgaag 3219481 gcctgccgca acaagtcctg cgatatgtgc catatccacc atgaagtaag cgccgacttc 3219541 atcagcaatt tcacggaatt tcttaaagtc gattgtacga ggatacgcac ttgctcctgc 3219601 tacgataagc ttcggtttat gagcgagggc tttttcacgc acgtcatcgt aatcaatata 3219661 ttgagtttct ttatctacgc cgtactcaac aaagttatat tgaacaccgc tgaagttgac 3219721 tgggcttccg tgtgttaaat ggccgccgtg ggagaggttc atcccaagta cagtatcgcc 3219781 ttgctccaaa atcgtgaagt acactgccat gtttgcttgt gcgcctgaat gaggctgaac 3219841 gtttacatgc tccgctccaa agatttcctt cgcgcggtca cgggcgatat cttcaacgac 3219901 atcgacgtgc tcgcatccgc cgtagtagcg tttgcccgga tatccttctg cgtacttatt 3219961 tgtcaaaaca gatccttgtg cttccataac cgcttcactt acaaagttct cagaagcaat 3220021 caattcgatc ttagtctgtt ggcgttcacg ctcattttta atggcgttaa acacttgttc 3220081 gtcttgcgca ggtaaatgtt tcatcagcga gatcctctcc tatccgtatc ctgttctttg 3220141 tttttaccat cactattgta catggttttt aaggccgatg taaaagatta tttttaaaaa 3220201 atctaaattt ttattggtaa aaacgaatat taataactta aatttaattt aaagttcgga 3220261 atttatttca ctatcttaaa ataaaagaaa agactggcta tgcagtcctt tcattcgcac 3220321 tcataaaccg cccgcactcc gccgattagt ttcggccgtg tacgcgccaa tgtcacatga 3220381 gctgaaccga ggctgttttg agagacacgc acagggacag ccaccggttt cagatgcatg 3220441 ccgataaacg tatcgcctat atcaattccg gcgtcagcct gaatggtttc aacaagaaca 3220501 ggagacttca tctgcttaaa cgcataagac gccatcgctc cgcccgcttt tggaacgggc 3220561 acggcagaaa cggttggaag cctgaacagc ttggctgttt ctgcttcgac gacaagcgct 3220621 ctgtttaaat gctcgcagca ttgaaacgcc agatggattc ccgttttttc ccggagctca 3220681 gcaagtccgc tgtagatgct ttcagcgata tctacactgc ccgatgtgcc gatccggctg 3220741 ccggccactt cgctcgtgct gcatccaagg acgaagagct gatcttgttt caattccgct 3220801 tggtcctgaa actcagacag catcgtcttc cacgtttgtt tcaactcatt cattaaacag 3220861 cacccctaca ggtttttctc ttcataatcg gagatttttc caatacgcgt ttggtgtctt 3220921 cccccggtaa actcagtagt cagccagatt tttgcgattt cccgagccaa accaggtccg 3220981 atcacccgtt cacccatcgc aaggatgttt gtgtcattat gctccctcgt cgccttcgcg 3221041 ctgaaggtat cgtgcgccag cgcgcagcga atccctttta ctttattagc ggaaatgctc 3221101 atgccgatgc ctgtcccgca aattaaaatg cctctgtcaa cttcgccgct aaccactttt 3221161 tcggccaccg gaaaagcata atccggataa tcgacagagc cgctgccgca gtcacagccc 3221221 atatcaatat attcaatttg caattcgtcc attaactctt tgatttcatt tcgaatgtga 3221281 acgccgccat gatccgatgc aatggctact ttcatctgct tttcctccca gcgtgtgtga 3221341 tgcggcccgc ccgctttatt gaccgcgcag cctgtccgct ctttgattca caccatatga 3221401 tgtgcttttc actatattct actccttcac gcaggatttg caaatgacct gtttgcagat 3221461 tttctgacaa cttatctacg gtcttttttc agctgttttg ccagctgccg aagaagctct 3221521 tcaagctcat ctcgcgtttg tttatagatg tcaattgagc cgccgaacgg atcgaggaca 3221581 tcaccatggc tgcctgtgac atattctttt aacgtaaaca ctttatcacg ataacgtcca 3221641 aattggctgg caatgatctg tttgtgctga tgggtcatag ccagaaccaa atcagccgat 3221701 tccataagtt cttcagttaa tggagaagac acatgattaa gggcaatgtg tttttcaaac 3221761 agcgcttcga ctgcatgagg cgtcgctttc ccattaggtg aagcaaacac gcctgccgag 3221821 cggacattga cattcagccc ttccctttct gcaattgatt taaaaagcgc ctcagccatt 3221881 gggctgcggc acgtatttcc agtacagaca aaaataatat ccatgtcagt caccccttat 3221941 ttttctctat tatatatgaa gaaaaaagaa acggcgactt cgtttctttt attggtatat 3222001 taaattggca aaagcagctt taatccaaac acgattaata tgatgccccc gagcgcttcg 3222061 ctgtatgtgc caagccatga ctgcacttgt tttccgacca gcaggcccag ccatgtcaac 3222121 atcatgctga acagcccgaa cagggtaatt gtgaggagcg gatgcgagcc gtatatcccc 3222181 aagctcaagc cgacggaaaa gctgtcaagg ctgacgccga tggcaaacag caataagccc 3222241 ggccctgccg gtgacatgaa tcgttcttct gactgtttaa aagaggccat aagcatttga 3222301 accccaagaa caaaaagcag cgccccaccg atataaaccg ctaacacgcc gaggagccct 3222361 gacagcatgt taccggccgc catccctgcg agaggcatga tgacgtgaaa gaggccgatg 3222421 atgaaaccaa tatagaatat ctgcttcttt ctaagtttga ccatgcccat tccaaggccg 3222481 acagaaaaag catccatccc taaagcaaac gccatgatgc ttaatgtaat cagttcgcct 3222541 ataaacaaat ccgacataca taaataaccc ccttggacac gccccgcttt tttagcctat 3222601 gcgtgtccaa aaagggttag aacatctgac tgctttcagc gaatcactct tcctccggcg 3222661 gctttcatca gcctgttcat aatagcaaga ccgacacctg tatccggaaa ggattccgct 3222721 ataatgaaat ccaccttatt ctcatcaaag ctgcgcaaag catcatacag ccctgccgca 3222781 acagtctcaa gctgagcccg tcttccgcag ctcttcacat aatcagcgga ataaacgccc 3222841 gctttttctt ctgtcgtcag gacaccgacc cgtcttccac cctgttgata ttcttgaatg 3222901 aggtgctgaa tgcgctctgg gctgccttcg caaatggcaa gaggcgctgt cggcgcataa 3222961 tgtgtatatt tcatccctgg agaaatcggc ttctcgtttt ggtcgctgag ccctttatcc 3223021 acatggatcg gcccgatcac cgcttcaatt tgttccttcg taatgccgcc aggacgcaag 3223081 agaacaggga tgtcgtccgc acatgaaagc acagttgatt cgaccccgat tccggtaggg 3223141 cctccatcca caataccggc tatgcggcca tccaagtcgt gagccacatg ctccgctttt 3223201 gtgggacttg gcttgcctga tagattggcg ctcggtgctg caatcggcag tcccgattcg 3223261 cgaatcaatg caagggcaag cggatgatcc ggcattctaa tggcaaccgt ttcaagacct 3223321 gccgttacac gaggtgaaag cgcatcaggt ttgcaaggca gaatgagcgt aagtgctccc 3223381 ggccaaaacc gtttcatcaa tgttttcgcc ttttccggcg ccgggcccgt taaatcctca 3223441 agctggctga tatccgcaat gtggacaatc aggggattat cgctcggccg ccctttcgcc 3223501 tcatatattt ttttgacggc atccgtattt tttgcgtttg cgcctaggcc atatactgtt 3223561 tctgtcggaa aggcaacgac ctcattttct cggagcaaag cggctgcttg tgcaatttgt 3223621 ggatcatttg tggataactc gtcagttaca tccacaaacc atcttttcgt tttcatttct 3223681 gaccaaactc cttattcaca acaataaaac gattgtttta cgcgtgtaat ccttttgaaa 3223741 gtataaaaga tgtcctgtaa taaaacaagc gttatccaca aattgtggac aacgctaata 3223801 aagaagtgga taagtatgtg tataaactgc acttatccag acgctttttt catcaaaacg 3223861 gctccttctg tttgccgcga ttcacagaag tgatcagaag aaaacagctc ctccggtaca 3223921 ctctcagctc tttcaaaacc catggccgtc agaaagtccg cagaggaatg ctgatttgct 3223981 actaggtaca cggttttgat ctgatgcttt tcgcacagca cctccatgct ttgaaaaagc 3224041 gtgacgatgt ggccttggtg aagcttgtcc gatatgacaa gtgatcgcag cagcccctgg 3224101 tcacagctta ttttttcaat accgaggcat ccggcaatgt ttttctcact gtcctccagc 3224161 ataagaaatt gagtgaagcc ttctttcacg ccttcatagc tggtttttgc ctgttttaaa 3224221 aatgcctcga gcacatctcc gtctttttcc cttgccaccc gcagttgata aaacatccgt 3224281 tcaccccgtt tttgcgttct ttcttccaat ctatgaggca aatctatttt tagaccagat 3224341 gattaggaaa aaaggtcgga aatccattcg actaaaaaga atttcacttc tgtgccgtct 3224401 tctttttctt cgttctcttc ttttttggct ttttccgctt tagcggttac gtcctcaagc 3224461 actttttcag tctgcttttt tgaggcttct ttatcttctt gttctttgac ggcttccccg 3224521 ttagaaaaat caagaaagca gaggggcggg aacagcacac accaccagtt ggcgccgtct 3224581 ccgtttccaa gcgtaatcaa aatcgcttca tactcaccag cgggatatac catgttgccg 3224641 taaagctttg tcggaaacga gattttgtca aaatcaacgg atatcgactg attcgctcct 3224701 tctttctcca ttgtttcctt tgcaattgct ttgatttcag gcagctttga acgaatcacg 3224761 cgacgcgctt cttcaataga agtaatatcc tttacccaag ttgtgatttc tttattcacc 3224821 gcgtctctta tatgacgttt taattgctgg tcttgatcac tatcgctgtt tgccagtatt 3224881 ctcaaacgaa tcgcctgatc aggtatgacc accggctgat tttccgattt ttgtgccgtc 3224941 tcttcttttg ccagccctac gagcgctccg gataataaaa gaaagatata tatacaaatg 3225001 attactgttt ttttcatcgg tccccaccgt tcctctccgt gctttgtttc tagccctatt 3225061 atggacaagg agagcctggg ataaacgtgc agggtgaaaa aaatctagca agctgttaat 3225121 cttatttatg gtacgatagt gttttaggag gtttaagatg aaatacaatt atacagtgct 3225181 gttatcagca ttcacgatgt ccgttcttta ttcagtaatt tatattcatt catttatcat 3225241 tgccgctctc atcacaatgg cattttattt tctgtttcct tatttgatct tcgcactgcc 3225301 gcttcaaatc atgatgaata aaaagccgaa acgtttcagc cctttgtatc tgctgtatta 3225361 ccttgccgct gcttttattg ccaacgcgat cattttcggc atgcttcagc cttcgggaca 3225421 atctctgttt caaaatacag ccttttatct tttcgctgta ttaacagctc ttatctattg 3225481 gatatgggat tctgttttac tgcaaaaaaa ggaagcctaa gaggcttcct tttttattaa 3225541 aacaaaatcg tcagtaaata acatagaatg gaaggtatcg ccgcaacaaa gaaagcggcc 3225601 gccattttca tgcgagatgt acggccttct ttggtttctg aatggtagtt tgcccgctga 3225661 tcgcttccgc ttacagccaa acccgatgta atgatcgcga gccccactaa aacgagagac 3225721 gcaacgccaa aaatcgcttc atatgaaaga gcctgcggaa aaatggtgcc aatcatgctc 3225781 tcaatcgcaa tgagcaggat tcctgctgtc agggcctttt tcatgtttac atcccctttg 3225841 ctggtgttaa acagcttgat ccattcactc gccagcaagc tgcttattta tttttatgaa 3225901 tcagagcgca tatggttctg tcttttccat taatatcttt cagcacttcc acttccgccc 3225961 ccttaaacgc cttgaggatc aggtctttga ccgccgctcc ctgtttccag ccgatttcaa 3226021 aaacgacaaa tactttatcc ttcataacaa gcggaatgtc ttccataaac cgcttataaa 3226081 atttcagccc gtctccgcca tcggtgagtg cgtgcagcgg ctcatgaaaa cggacaattt 3226141 ccgataaatc agccatttct tcctctgaaa tatatggcgg gtttgagaca atgatatccg 3226201 ctttttttcc cgccttaata aaaggctcaa gcagatcgcc ctgataaaag cgcacattcg 3226261 ctccgagttt ttctgcattg gcagaggcga cttgcagcgc ctctttcgaa atatcgaccg 3226321 ccgacacaga aaagctttgg ttttcaagcg caagcgtgac ggctattgcg ccgctccctg 3226381 taccaacgtc aacaacttcg agcttgccgt cttcagaaaa aacactccga tatttttcaa 3226441 gcaaatgaaa gacaacttct tcagtttccg gccgcgggat cagcacatca tcattcacca 3226501 taaattcccg tccataaaaa aactcttttc ctataatgta ttgaaccggc acgccctctt 3226561 tatgcatctc aacgtgacgc ttaaagcgat acagttcgtc ttcaccaatc ggttcctgta 3226621 agcttgcgag cagcttgctt ctctccattc cggtatcata aagcaatagg agctcggccg 3226681 cattttcttc tcttcccgct tcggttaaat aagaagaagc ccatttcagg gcttcgaata 3226741 tcgtcttcat cttaaccttc cgactgctga agcttgcttg cctgatcttc aacaatcagc 3226801 gcttcaacca cttcgtcaag ttttccttca agaatctgat caagcttttg aatcgtcaaa 3226861 ccgattctgt gatccgtcac acggttttgc gggaagttgt atgtgcggat acgttcagag 3226921 cggtcaccag atccgactgc tgatttccgt gtttgatcat attcagcctg ggcttcctgc 3226981 tgaaatttat catagattct ggcacggaga accttcattg ctttttcttt gttcttaatt 3227041 tgagattttt catcctggca tgatacaaca acacctgtcg gcaagtgagt cagacgaacc 3227101 gcagacattg ttgtgttaac gctttgtccg cccggtccgc ttgaagcaaa tgtatcgaca 3227161 cggatatcct tctcatggat gtcgacctct acctcttctg cctcaggaag acatgccact 3227221 gttgcagtgg atgtatggat gcgtccgcct gattctgttt ccggaacacg ctgtacgcgg 3227281 tgggcgccgt tttcatattt gagtttagaa tacgcgccgc ttcctgtaat cataaagatg 3227341 atctctttgt agccgcccgt tccggttaca ttcgcttcca tgacctctgt tttccagccc 3227401 tgaagctcag cataacggga atacattctg tacagattgc ccgcgaataa agcggcttcc 3227461 tcgcctcccg cagccccgcg gatctccatg ataacgtttt tgtcgtcatt aggatctttc 3227521 gggatcagga gcaccttcag ccgttctgac agtgtttccg tttccttctg aagttcagaa 3227581 atctcttcct tcaccatgtc gcgcatctca gcatccagct tctcttcaag catcgctttt 3227641 gcatcagcca gctgttctga cgcatctctg tattgtctat atacgtcaac tgtttcttgt 3227701 atatcagatt gctcttttga atattctctt agctttttcg gatcgttgac tacttctgga 3227761 tcgctcaaaa gctcatttaa tttctcgtat cgttcttcaa ttgattttaa acggtctaac 3227821 acggtcttca cctctgtttt cctgtgcgta acattctcat tatagtatag tgattaaccc 3227881 cagtcaaaag catttcaatc ccagctggaa aagctccctc tgctatactg gaattcgagg 3227941 agggatgatg ttgctgaaat ccatacatca tattgcaatc atatgttcag attacgaaaa 3228001 gtcgaaagct ttctacgtac ataagcttgg ttttcaggtg attcaagaaa cgtaccgcga 3228061 agagcgcggc tcctataagc ttgatttgtc gcttaacggc tcgtatgtca ttgagctgtt 3228121 ctcgtttccc gatccgcccg aacgacaaac ccggcctgaa gccgcaggcc tgcgccacct 3228181 cgcctttaca gtcggcagct tggataaagc tgttcaagag cttcatgaaa aaggaatcga 3228241 aacagagcca atcagaacag atccgctgac cggcaagcgt ttcaccttct tttttgatcc 3228301 tgaccagctt ccattagaac tgtatgaaca ataacagttt ttgaagaaaa aaaggagata 3228361 cccactttct ttgccgaatc ttttcttgtt ttgtctaacg ggaagggaac cgcattctat 3228421 ggtcgaatac ctagcttaaa aggaggtatg ggatcatgaa tacaaatatg gtagcaagtg 3228481 aactcggcgt ctccgcaaag acggtgcagc ggtgggtgaa gcagctgaat cttccggccg 3228541 aacgcaatga gctcggacac tattcgttca cggcagaaga cgtgaaggtt ctaaaatccg 3228601 ttcaaaaaca aatctctgaa ggcacggcga ttcaggatat tcatctgccg aaaagcgcta 3228661 aaaagcgcac aggcttcctt gtccaaaaaa caagtagcga cacagaacga agaatcgagc 3228721 agcttgaaca aaagctggac acccttttac agcaaaggca ggacgaaagc gaattgatgg 3228781 caaggatgtc ggaactggaa cgccagctga aacaaaaagc cgatgaaggt gtatcttacc 3228841 agctgcttca gcaccgcaga gaaatcgatg atattcttgc agatctgcaa tcactgacct 3228901 cacaaatgaa agaattcacc gctcattcga tccccgagac tgctgctgct tctgaaaaaa 3228961 ccaaaacaag aaaaaaaccg ctgctgtcac tgttcaaatt tcaaacctaa agcaaaaagc 3229021 tcccttaaag ggagcttttt ttgttacgca gtaagcgcga taatgattgg aagtgaaatc 3229081 aatgacagaa tcgcactgac cacaaacgca gttgcagttt cttcttcttg tttctcgaaa 3229141 cgagtcgcaa tcatggctgc aacggcagaa ccagggaatg caacaagaag gattgctttt 3229201 gttgtttggt cagctggaag tccgatagca agagcaatca ggaacattaa cgcaggctga 3229261 accgcaactt ttagtaacgc aataccgata gccggcatac tgagtttaat tttacgaata 3229321 ccaacggtaa caccaacagc gaagagagca acaccagatg ttgtgcttcc aagctgatca 3229381 agcattttaa cacccagctc aggaagagtg aaattgaaaa ccagcaccaa gatcatactg 3229441 attaacggag cagctgcaag cggctcacaa agaccatgca ggattgattt tcctgtcatc 3229501 ttccagaagc tgtcgccact ctcttcgttt ttcttagaag actcaccaac agtagcgata 3229561 atgatcgcga gcggatcaag aatcgcgtta accacgatac ctgtgaccgc gatcggaatc 3229621 gcaacttcat tcgctccgaa taagcttccc aataccggga tacccataaa tgcgaatgtc 3229681 ggctgtgcag agttcaaaga aaatacagat gagttcgtta aatcatactt gaatataaat 3229741 ctgcaaacca aaagaatgat gatatagaaa ccaacaatcc caataattaa agaaatcatt 3229801 aaaggtactt gtgataaaaa ttcacttctg gaagttgtca aaataccagc gataaagtga 3229861 gctggaagtg cgtatttcgt tactaacgta cttacccctt ttgccgactt ggcatcataa 3229921 cttccaaaat gtcctgcaaa ccaacccagc acgataacaa agaagatcgg cgccaggagg 3229981 attaagatat ctaagatgct caaaatattc tcctccaaat cctatgtccg tatactttag 3230041 ctttacaaaa agctttccct cggacagaaa aatttactcg ctaattattt cgcgatgact 3230101 tttttgtatt caggtgtcca cattgcatca agtaccgctt gtttcacatc ttcaggctga 3230161 cgatttgcca cgccgtcttt aattgctgct tcagcaacgg caatcgcaac ttggatagaa 3230221 acctcttgaa gcttatcaat gcttggaagc aatcctgctc caggtgtttc aagatcaacc 3230281 atttcagcaa tcgcatcagc agttgcagca aacatagcag gtgtaatgat acgcgcttca 3230341 gctacaattg aaccaagtcc aagaccaggg aacgcgaatg cgttgttaga ttgtccgatt 3230401 tcataagaaa caccgttgta ttctacattg tcaaatgggc ttcctgttgc aataagcact 3230461 tttccgtcag tccatttgaa cagatcttca ggaacagctt cagcaaggtg agtcgggtta 3230521 gacatcggca tgataaccgg acggtctacg tgagatgcca tttcttttac aatttcctct 3230581 gtgaatgcac ctgaaacccc tgaagtacca atcaagattg ttggtttcgc ttgacgaaca 3230641 acttcatcga atggaatttg acctttttca tcgcgcttcc agtctttcac ttcatccgca 3230701 ttgcgaaggt aaggtttttg gaaatcaagg atgccttcga tgtcttcagt cagcaagcct 3230761 ctgtaatcaa gtgtgtagaa acgtttgtta gcttcttctt cagataatcc ggctagcacc 3230821 attgtgtcac ggatttggtc agcaataccg ataccagcag aaccagcacc gaagataaca 3230881 acacgctgat ctttaataga agcgccggtt ttcttcatag cggcaagcac acctgcaagt 3230941 gtaatcgcgc cagtaccttg aatatcatca ttaaatgtca ggatttcatg attgtatttt 3231001 ttcatgatgt tgcgtgcatt tttgttgcca aggtcttccc agtgaagaag cgctttaggg 3231061 aagaatttca atgcagcttt tacataagcg tcaatgaaag cttcgtagcg ttcaccttga 3231121 acacgttcat gcttgttacc aatatataaa ggatcgttta gaagtttttc gttgttcgta 3231181 ccgacatcaa gcacaaccgg gataacacgg ctagggtcaa taccagctgc agcagtgtag 3231241 acagccaatt taccgattgc aatattaata ccgcctacac cccagtcacc gataccgaga 3231301 atgctttcgg agtcagtagc aacgataaga tcaatatcgc ctgctgtcgc atgaaggttt 3231361 tcaaacgctt tttcaatacc gtcaatgtta tcgattgaca agtagattcc ttgaggtctt 3231421 ctatattcat ggctgtattc ctgaatcgct tcaccaactg ttggcgtgta cacaacagga 3231481 agcatttcgc gaagatggtt tttcagcaat ttatagaaaa gaacttcgtt acggtttgca 3231541 agatcactta agtaaacatt ttgacgaagg cggtcaggct gcgcttggaa ttgctcgtac 3231601 gcgcgttgtg cttgttgatc aagagaaagt acagttggcg gcagaagccc ttctaagccg 3231661 agttcttgtc tttcttctag tgaaaaagca acgcctttat ttaaagtagg aatagataaa 3231721 acttcttttc ctctaagagt tgtttctaag tggccttctt tcgttttttt tatgttattc 3231781 aagcaaatct ccttctttct tgaaatagtt aaccaagtta agtaataacc catctaaaat 3231841 atgaccgatc atgatcttta tgcgactttg tgacaattat tcgaacaatg tctcaaaact 3231901 atttacatta cgtaagctat tgtatgcctg tcaaaatcaa aattcaagag aagaaaatta 3231961 cttaattttt taatatactt atttaaattt tttaattgaa tattatcaga atataaaaaa 3232021 aacaccggtg tttttagccg gtgcattcta tctttatacc catgttttgg actatttttt 3232081 agatttacct gggacttcgt gatgatgtct gcatcttgct tcatatgatt cagctgcacc 3232141 aaccaaaatg accggatcat cgtaagaagc aggtttgccg tcaatgaggc gctgtgttct 3232201 gctcgccggt gatccgcaaa cagaacagac ggcttgcagc tttgtcacac tttccgcaat 3232261 cgccatgata ttcgggacga caccgaacgg ctctccccta aaatccatat caaggcctgc 3232321 tgctatcaca cggtagcctt tatcggcaag agatgataaa acctcaacaa tttcctgatc 3232381 aaaaaactgc acttcatcaa ccgcaaccac atctgtactt tcactgatgt gatcccaaat 3232441 gtccgcagca gacgaaatgg catagctcgt catcgatgtt ccattatggg agacaacagc 3232501 agcttcgctg tatcggttat caattacagg cttaaatacc ctgacttcct gcttggcata 3232561 agttgctctc ttcactcttc tgatcagctc ttcagatttc cccgagaaca tgctgccgca 3232621 aatcagctca agccacccgc tttgtttcat tatgtacata ggcttcgctc ccctctctct 3232681 gccagctgtg ttttagacaa tataaaaaac aggcaagact gctgcttgcc tgttgagaaa 3232741 tctattatta cttaagaccg tattttttgt taaagcgatc aacacgacca tcagcagaag 3232801 cgaatttttg acggccagtg tagaatgggt ggcattcaga gcaaatctca acgcgtacct 3232861 cttcttttac tgagcctgtt tcaaattcat ttccgcaagc gcatttaact gttgcttttt 3232921 tgaaattagg atgaattcct gctttcattg tatccatctc cttccgccct gaatcccgtg 3232981 tggaaacaga gttattattt cggagcattg tccgaaacgc atatgagaaa attatatcag 3233041 tgatttactt cttttgcaaa tacaatttac cttcttgcag atgatagatt tgcctgtttc 3233101 cattcttgat tgagaatatc gaaaaattcc tggtttgttt tggttttttt catttttctc 3233161 atgaactttt ctgcgaaatc aggtgaatca gacatcgttt tgcggataga ccataaacga 3233221 tcaagatgct ctttaggcac aagcagctct tctttgcgcg ttcctgaacg gcggatatcg 3233281 atggcaggga agatgcggcg ctcggcaaga gagcggtcaa gatggagctc catgttgcct 3233341 gttcccttga attcttcata aatgacatca tccatacgtg aacctgtatc gaccagagcc 3233401 gtagcaagga tggttaagct gccgccctct tcgatatttc tcgcagcccc aaagaagcgt 3233461 ttcggacggt ggaacgccgc tgggtcaatc cccccggaaa gcgttcttcc acttggcgga 3233521 atcactaagt tgtaggcgcg ggcaagacgt gtgatgctgt ccatcaggat aatgacgtct 3233581 tttttgtgtt ccacgagacg catcgcacgt tcaagcacaa gctcggccac tttgatatgg 3233641 ttttccggca cttcatcaaa cgttgagctg acgacatccc cagctacaga gcgctcgata 3233701 tcggttactt cctcaggtct ttcgtcaatt aaaagcacga tcagctctgc ttcaggctgg 3233761 ttcgctgtaa tgctgttggc aatttccttc agcaacatcg tttttccggc tttcggcggc 3233821 gcaacaatca atccgcgctg cccaaatcca accggcgcca tcatgtccat aattcttgta 3233881 gacaagaagt tcggctttgt ttcaagcacc atttgacgat ccggataaag tggcgtaaga 3233941 gccgggaaat gcacacgctc ttttgcagat tcgggatcat ccccatttac tgcttcaacg 3234001 tgcaaaagtc catagtaacg ctcattttct tttggcgggc gaaccttgcc agatactttg 3234061 tctccgttcc gcaaatcgaa acggcggatt tgtgaagctg agatgtaaat gtcttctgag 3234121 cttggagagt agttgatcgg tctcaggaat ccgaaacctt cagactggat gatctcgaga 3234181 acgccttcca taaacagcag atcttcctgt tctgcattcg ctttcagaat ggcgaaaatg 3234241 agttcttttt ttgtcagttt gctgtaatag gagattttat aatgtcttgc aagttcataa 3234301 agctctttca atttcatatt ttccaaagag gaaatagata cgtctttcat aaaaacacca 3234361 cgcttttcat agtcaatatc ttactctgaa catgtcatct gctgcttttg cacaacatcc 3234421 gccaaagcac attctttttt taacataaag gaacttctat cggtaacact tccacccatg 3234481 atcggcgctt ttgttaaaag gattgtctta atgagttttg aaggaagcga ggacaaaaac 3234541 atgagaagat caatacttat atcgtctgta tgcggtagaa attgaaactt tcctagtgct 3234601 taaaagaagg tattacgcag taaaattcgc agcactcttt atttttacct tatttcaaaa 3234661 aattattcaa ctgaaataag gttttgacac ggaattgata gagttgacgc ttttctgcaa 3234721 aagttaaagc gggctcacac ccgctttttc tgtttgttat ggacggatta caagatttgg 3234781 tttctttttc aagctgtgtc tgccgtcaac gaaacgaaca gtgcccgatt ttgcacggat 3234841 aactaagctt tcagttgtac cgacagagcc tttgaattga actcctttta acagctcgcc 3234901 gtcagtaacc cctgtagctg caaaaatcgc gtcatcaccc ttcacaaggt cttccatgcg 3234961 aagcactttg cttaaatcaa ggcccatttt gtgacagcga gtgatttctt cttcgctttg 3235021 cggaagaagt ttaccaatga tttctccgcc gagtgctttt agcgcaacag cggaaagcac 3235081 accctcagga gcgccgcctg atccgaacag gatatcaacg cccgtgtggt cgaaagccgt 3235141 gttgatggcg cctgcgacat cgccgtcatt gatcaatttg attctggcgc cggcctcacg 3235201 aagctcggaa atgatttttg cgtgtctttc acggtttaaa attgtggcaa cgacgtcctc 3235261 aacgtccttg tttttcgctt ttgccaccgc tttaaggttg tcaatgacag gtgcttcgat 3235321 gtcaatgcag cccaccgctt ccggaccgac tgcgattttt tgcatataca tgtcaggagc 3235381 attcagaagc gtgccatggt ctgcgaccgc gataaccgtc agcgcgttcc agccgccgct 3235441 tgctaagatg tttgtgcctt caagagggtc aactgcgaca tcaacgcgag ggccgtaccc 3235501 gtttccgagt ttttccccga tatacagcat tggcgcttcg tccatttccc cttcaccgat 3235561 tacaacggtc cctttcatcg gcactgtatc aaaaacgtct ctcattgcac ttgttgccgc 3235621 ttcatcagcc tcatcttttt ttccccggcc catccatctt gctgatgcca atgccgcagc 3235681 ttctgtcaca cgtaccaatt ccattgataa acttctttcc atttcaacac gatctcctct 3235741 cacaagaaac cattatgaat tttgaagctg ttctatttct tcgtcagtca ttctttcacg 3235801 ccaaattgtc gctccaagcc cctcaagctt cttctcaagg ctgctgtatc ctcggtcaat 3235861 atgctccagt cccgtaattt ccgtgacgcc atcagccatc agtccggcta ccaccaagca 3235921 ggctccggca cgcagatcac tcgccttcac ttttgcgcct tgaagctcga caggacctgt 3235981 gatgatggca gatctgcctt ctactttcat attggcaccc attcgtctca gctcatcaat 3236041 gtgcttgaat cttgccgagt agatggtgtc tgtgacgaca ctcgtccctt tcgcccttgt 3236101 caggagcgcc gtcatcggct gctgtaaatc agtcggaaac cccgggtata cgagggtttt 3236161 gacgtcaacc ggctttaagt tcttctgccc gccgacaatg aggagctggt cgtcgcttgt 3236221 ttcgatatga tagcccattt ctctcagctt tgccgttaac gactcaagat gagtagggat 3236281 gacgttatcg ataatgactt ccttgcccat tgcagcccct gcaatcataa atgtcccggc 3236341 ttcaattctg tccggaatga tcgtatgctt gcagccgtgc agttccttca cgccgtcgat 3236401 tcgaatcaca ttggtgcccg cacctttgat tttggcgccc atgctggtaa gcaatgtcgc 3236461 gacgtcaatg atctcaggct ccttggcagc gttttcgatg atcgttttcc cttctgccaa 3236521 aacagcggcg agcataatgt taatcgttgc cccaacgctt acgacatcta aataaatccg 3236581 tgcgcctctc agcctttcag ctcgcaaata aatggcgcct tgttcattgg ttacttcagc 3236641 tccgagtgct tcaaagcctt tgatatgctg atcaatcgga cggggcccta agtgacagcc 3236701 gccaggcaat ccaatgaccg cctgcttgaa gcggccgagc atcgccccca ttaaataata 3236761 tgacgcgcga agctttttta ctttcccgtt aggaagcggc atgctgatca tcgacgtagg 3236821 gtcaacaacc atttccccat tctcaaaatg cacgttgccg ccgatttcct ttaacaggtc 3236881 acgcagcgtt tcaatatctg aaatctctgg aagcccttca attgtcacct cggaatttgc 3236941 caaaatggtt gcaggtatta acgcaacagc gctgttttta gcgccgctga tatgtactgt 3237001 accgtttaac gagtcaccgc cggcaatatt caacttttcc atgatagtct ccttccataa 3237061 gaagatagct gcggagctaa ataaaatgtc attttattct gtctctgcaa ataaagctca 3237121 tgtccaaaat ctagccaatt cgaagagaaa gaatacaaca cattgtaaaa tatcaggaag 3237181 aaaatagcga agctttgggg ggtacaggtt tcaaaagatg cacagagacc cgccggctcg 3237241 agagacatcg tcgtcatccg gcaaaagcag tacgcatacc cttcattccg atatcagctt 3237301 ctgcagccca atgattcctt ctctgtaaag cggcgtcagc atctgaagat ccgctgtatc 3237361 aggtcggtga aatacaaagg ccgcggcaaa caggcataaa gctgtttgcc gcccctttca 3237421 ttatttgttc cagtctgcca ggaattgttc gattcctttg tctgttaacg ggtgtttagt 3237481 gagcgcatga atgactttca gcggcattgt gccgatatga gcccctctaa gagcagcttc 3237541 tgtcacgtgc tgcggatggc ggattgacgc tgcaatgatt tgcgtgtcaa ggccgtgaat 3237601 gtcaaaaatc tgtttaactt ctgaaatcag gtcaagcccg ttgtggccga tgtcatctaa 3237661 acgtcccagg aatggagata catatgttgc ccccgctctg gcagcaagaa gcgcctggtt 3237721 ggcattgaag atcaatgtaa cgtttgtttt gatgcctaag tcagtaagtg ctcttaccgc 3237781 ttttaaaccg tcagacgtca ttgggatttt caccgtaatg ttcggagcga tcttcgccag 3237841 ttcttttcct tcctcgatca tttcctcagc tttcaaagaa ataacctctg cgcttacaga 3237901 ccctttcacg acgtctgtga tctcgcgaag acggtcgtgg aatgatacgt tagcttcctt 3237961 tgctactaaa ctaggattcg tcgttacacc ggcgagaatt cctaattcat tcgcttctct 3238021 aatttcatcg atattggctg tatcaacaaa gaataacatt ttcaaaaagc ctccctgatt 3238081 aagaaatttt ctgaactgcg aatatgattg cgctttctaa agatagacgg aaaaccgcct 3238141 gtcaagctgt caggcggcta taaaaagttc caattgaatt aagcttggtt tgaagaacca 3238201 aattcacgca ttttaccgat aactgtttct ttgatcgctt cacgagctgg tccaaggtat 3238261 ttacgtggat cgtactcgtc aggcttagct gccaatgttt cgcgaacagc ttttgcagaa 3238321 gaaatttggt tttcagtatt cacgttgatt ttagctgtac caagtgaaat tgattttttg 3238381 atgtcagcag tcggaattcc agtaccgccg tgaagaacta gcggaaggcc agttgatttt 3238441 ccgatctctt ccatttcttt gaagccaagg tttggctcac ctttgtaagg gccgtgaaca 3238501 gaacctaatg caggtgcaag gcagtcgatg ccagtgcgct caacaagctc ttggcactct 3238561 ttaggatcag cgtagattac gccttcagcg ataacgtcat cttcttgtcc gcctactgtt 3238621 ccaagctcag cttctacaga tactccgtgg aaatgagcaa gctcaacaac tttagcagtt 3238681 gttgctacgt tttcttcaaa tggatggtga gaagcgtcga tcattacaga tgtgaaacct 3238741 gcatgaatcg ctttcgcaca agattcaaag cttgaaccgt ggtctaagtg aatcgcaaca 3238801 ggaactgtca ctttgtactc ttccataagt gcttttacca tagcaacgac tgttttgaag 3238861 ccgcccatgt agcgtcccgc accttcggaa acaccaagga tcactggaga tttttcttct 3238921 tcagctgctt gtaaaatcgc ttgagtaaac tcaaggttgt ttaagttaaa ttgtcctaca 3238981 gcgtaccctt tttctttagc tgtattcaac atttccgtca tagaaactaa aggcatgtcg 3239041 aatgtcctcc ttatgtagcc tgattgtctt ctagcgaaaa aagctttcca ccctagcatg 3239101 acccatatat tgctgtcata tgtaaatact cagatcgctt tttctccata actaggatac 3239161 caacttttcg acaaatcggc aacataatga catgattcat ttgtttcttc tttttgtcag 3239221 ttagacttca ggggcagata ttttttgacg gcgtctctga tttcgtcgat gtcaaacggc 3239281 ttggcaaagt gcgtcagagc gcccaattcc ttcgattcct ggatcatgtc gagctctccg 3239341 tatgccgtca tgataatgac ccggatgttt tcgtcaatga ccttcatccg ttttaagatt 3239401 tcgattccgt ccatgccggg aattttcatg tccaacagca caaggtcggg ccgttctttt 3239461 gtcacaatgt caagcgcctg caggccgttc gcagcctgaa acgtctggta gccttcttta 3239521 ttgaacactt catttagcaa aatacgaatg ccgtattgat catcaacgat taaaattttt 3239581 tcattcatca ttttacaccc caatattatg attttcgtca aaagtaagca gtattgtatg 3239641 tattctgttt gattttccta tttcctttaa ttataatagt ctactttacg acattttctg 3239701 agcattttct cttttgttgt atactgatat tgtacgttat aaaggaggat tcacttatgt 3239761 tgaaaatatt cacgacgcag ttaacaggta ttttttcccg cattcaggat aaggaatctg 3239821 acgcgattga agatggggcg cggctgcttg ctcaagcggt gatcagcggg cattccattt 3239881 atttatacgg agcgaatgag cttcagggcg tcttttatga ggccaccgaa agcaaagaac 3239941 ccttcccatc tgtcaaagcc tttccagaaa acgctgagga agtgacagaa agcgacaggg 3240001 tgctgatgtt ttgctcaggg acgggcacag ccgaagaaca ggagctcgca aaagagcttt 3240061 atgaaaaagg tgcgggagtc gtatgcgtat cgcccgcagc caaagacagt gcgggaatag 3240121 aacagtattg tgatgtgcat attgattcta aattaaaaat gccgcttgtt cccgatgaag 3240181 acggcacccg ttacgggttt ccctctttaa tgacagcact gtatgtctat cacgctttat 3240241 cgtttacact aaaagaaatt ctgcaagagt atgcataata tcttattgta catgctggaa 3240301 cttgccggaa acaaataaaa aagacttgcc cgcttttgac aaacggcaag tcttttttat 3240361 tacttctgat ttgcagcttc gacagacgct ccgataaagc ctttgaatag aggctgaggt 3240421 cttgtcggtc ttgacttgaa ctctgggtgg aactgagaag ccacgaacca agggtggtct 3240481 ttcagctcga tgatttcaac aaggcgtcca tcagggcttg tgcctgagaa tacgaagcct 3240541 tgctcttcca tttgctgtct gaattcattg ttaaactcat agcggtggcg gtggcgctcg 3240601 tacaccactt catcctgata cacttcaaag gctttcgtgc cttcttcaag cttacaaggg 3240661 taaaggccga gacgaagcgt tcccccaaga tcctcaacat ccttttgttc aggaagaaga 3240721 tcaatgatcg ggtattgagt tgacggatca atttccgctg agtgagcgcc ttttaagccc 3240781 aatacgtttc gtgcgtattc aatagacgcc acctgcatgc ccaagcaaat gcccaagaac 3240841 ggaatgttgt tttcgcgcgc gtattttgtc gcgacgattt tcccttcaac accgcggtct 3240901 ccgaatccgc ccggcacaat gatgccgtct gttccgcttg tgagttctgc gatattgttt 3240961 tctgtcactt cttccgcgtt gatccacttc acttttacat ctgtgtcaaa cgcatagccc 3241021 gcatggcgga gagactcgac aacagaaatg tatgcgtcag gaagctcaac gtatttgccg 3241081 acaaggccga ttgtaatcgt ttgagacagg ttgctgactt tgttaacaag ctctttccac 3241141 tcggacattt ccgcttcttt gcatgccaat ttcatgtgct cgcaaacaag cttatcaagc 3241201 ccttgttttt gaagctccag cggaatggag taaaggttgt ccgcatcttc acattcaata 3241261 accgcttttg tatcgatgtc gcagaaaagc gcgattttat ctttcatatc ttgagaaatc 3241321 ggcatttctg tacgaacgac gatgatgttt ggctgaatgc ccaagctgcg caattctttt 3241381 acgctgtgct gtgtcggttt tgtttttaat tcgccagcag ctttaatgta aggcacgagc 3241441 gtacagtgga tgtacattac gttttcacgg ccgatgtcgc tcttcatttg gcggatcgct 3241501 tcaaggaatg gcagtgattc gatgtctccg acagtaccgc cgatttctgt aatgacaaca 3241561 tctgcgtttg tctctttccc tgcgcggtaa acacggtctt tcaattcgtt tgtgatgtgc 3241621 ggaatgacct gtacggttcc tccaaggtaa tctccgcggc gttctttttt aagaactgtt 3241681 gaatagattt tacctgttgt cacgttgctg aatttattca ggttaatgtc gataaaacgc 3241741 tcatagtgac caaggtccaa gtctgtttca gcgccgtcat ccgttacgaa tacttcaccg 3241801 tgctggtacg ggctcattgt tcccgggtca acgttgatgt atggatcgaa tttttgaatc 3241861 gtcacgttca gtccgcggtt tttcagcaaa cgccctaatg aagctgctac aatacccttt 3241921 ccaagtgagg atacaactcc cccggttaca aaaatatatt tcgtcatttc gtttgctcct 3241981 ctcttcgctc ttagctacat ttttaaaatg tactatttta taaaaaatca tttagccttt 3242041 taaatgattt ataagaaaaa tgaggggtga aaataagaaa gctccctttc aatttcttga 3242101 aagggagcat aacgtactat gttctctctt cgtttttgaa gagcccaaaa tacatactac 3242161 atagttcgac tatgaaagtc aagatcgttt tgaagatgaa atctgatact atttaatttc 3242221 ctcttcttca tcatcatagt cttcatcatc ttcatcaata atatcttctt cgatctcaag 3242281 atcatcgtcg tcttcatcaa gatcttcttc gtcaaaatcg tcggcttcaa gatcgagttc 3242341 ttcctcaact tcatccaaat caaggtcgtc ttcgtcgatc tcttcaaact cgtcaagatc 3242401 aagatcttct tcgactgctt tcttcgcttt tttctttttc gccttgactg tcggctgagt 3242461 ttcttcatca agctgatcat aaggatacca gctgcgaagc ccccacgtct ggtcagaaag 3242521 cgccaggaag cggccgtcaa tgtttaaatc tgtataaaat tgagcaatgc ggtctccaag 3242581 ctcttctttt ttcacgccga gcaaagatgc gatttcattt aaaagctcct gaaaaggaac 3242641 tggtttttta tgttcttcaa ataattcgtg agcgatttca actaaagcca tttcctttag 3242701 ctcttcctgt gaatattgtt tgatacccaa ggtcggacac tccctttcta ttacttatat 3242761 gtatctgttt tatcaataat gaaagcgatt ttgtatcgtt cttatacaaa ccatacctct 3242821 cattataaac aaaataaaac agaatatgct acccttaaca gcgttaattt aaataatttt 3242881 acaagagtga tccgactgag agatgttttc cgttaatccg cgagcattct ggagatgacc 3242941 agtctttgaa tttcttgagt gccttcatag atttgcgtga tttttgcatc acgcatatag 3243001 cgttctaccg gataatcttt tgtatagccg tagccgccga aaatctgcac ggcttcggtc 3243061 gttaccttca tcgccgtatc cccagccatc agtttggaca tggcggaagc ttttccatat 3243121 ggaaggcccg atgattctaa ccatgcagcc tgataggtca gtagccttga agcttctatc 3243181 attgtcgcca tatccgcgag tttaaaagcg atgccctgct gctcggcgat cgattttccg 3243241 aattgctttc gctcttttgc atattgaagc gccgcatcaa gcgctccttg ggcgatgcct 3243301 acagcttgtg cagctatgcc gtttctgcct ccgtcaagcg tcttcatcgc gattttgaag 3243361 ccttctcctt cttctccgag acgctttgat gcgggcacta cacaatcttc gaacatgatt 3243421 tccgttgtcg gtgaagaacg gatgcccagc ttcttttctt tcttgcctgt aaaaaatcct 3243481 tcaaaatcct tttctactat aaaagcggta acgccttttt tctttttctc gggatcggtg 3243541 acggcaaaaa caatgtaaat atcagcaacg ccgccgtttg tgataaacac tttggaacca 3243601 tttaacacat agtcatcgcc gattcgttca gcagttgttt tcatgctgcc ggcgtcagag 3243661 ccagaccctg cttcggtcaa agcgaatgcg ccgattttct ctccgagagc cagctgtgtt 3243721 aagtactctg tcttctgttc ctctgtccca aaggcaaaca gcggccagct gcaaagagag 3243781 atatgggcgg aaagcgtcac accggtggag gcgcacactt ttgacagctc ttccaccgcg 3243841 atgacgtagg ctaaatagtc acttccaatt ccgccgtaat cttcaggcca tggaattccc 3243901 gtcaggccca gatttgccat ttcccgaaac agctcgcgat cgaagcgttc ttgttcgtcc 3243961 cgttcagccg ctgtcggggc cacctcatgc ttcgcaaaat cgcgcaccaa ttttcgtatc 3244021 atctcatgtt cttctgataa tgaaaaattc attgcttctc ccccattttc agatcagcgc 3244081 ctaaaacgga ttgagccaga agctcgacga cgtcgtacgt tttgacttgg tcttcggctt 3244141 ccttcgcctt tgtgccgtcc ccaagcatcg tgagacaata cggacagcca gaactgatca 3244201 ccgatgggtt gactgcgagc gcttgctctg tcctggcgac gttaatcctg ttgcctgttt 3244261 cttcctccat ccacattaat cccccgccgg ctccgcagca catgccggtt tcccggcttc 3244321 tctccatttc aacaagctgc acgcccggaa tggctttcaa aatctctctc ggcggatcat 3244381 agacttcatt gtaccggccc aaatagcacg aatcatggaa ggtaatcgtc tcatgaagcg 3244441 ggtgctgcgg tcttaatttt ccgtttttca caagctcggc cagcacttct gtatgatgat 3244501 aaacctcgcc ttcaaatccg aaatccggat attcgttttt aaataaattg tatgcatggg 3244561 gatcgatcgt aacgattttt ttgacatcat ttttttcaaa ttcagaaata ttcttctcag 3244621 ccagctcttg gaacaaaaat tcatttccga ggcggcgcgg cgtgtctcct gaattttttt 3244681 ctttattgcc gagaatcgcg aaggacacgc ccgcgtgatt gagcagcttg gcaaaggaaa 3244741 ttgcgatttt ctggcttctg ttgtcgtaag accccatgga gcctacccag aaaaggtact 3244801 caaattcttt tccttctttt ttcatttctt ttacagtcgg aatctcagca tccggcgcct 3244861 cgtcacgcca attttcacgt tccttgcggt tgagtcccca cggattccct tgccgctcaa 3244921 tacttgtcat tgcgcgctgg gcgtcactgt ccatttttcc ttctgtcagt acgaggtagc 3244981 ggcggaggtc gatgatttta tccacgtgct cattcatgac cgggcattga tcctcacagt 3245041 tccggcaagt ggtgcatgcc caaatttctt cctctgtgat gacgtcgccg atcaagcttg 3245101 gattgtaatc aagcgccgct gcggcttcct gcgatccgct gcccgctgac gccgcagcca 3245161 gctgattgcc tctcgtatgc cgaaacgctg ctgcgggcac ccatggggag cgcgaggtga 3245221 cggcagcgcc tttttccgtg agatggtctc tgagacgcaa aatcaagtcc atcggagaaa 3245281 gcatttttcc ggtgcctgtt gcaggacaca tattggtaca gcggccgcac tcgacacacg 3245341 cgtatagatc aagcagctga gactgtctga aatcctcaat ttttcccgct ccgtagcttt 3245401 ctttcgtttc gtcggtaaaa tcaatttttt caagttttcc ggcagattcc attcgattga 3245461 aaaagacgtt tgccgggccg gcgattaaat gggcatgctt tgactgaggc acgtacacta 3245521 aaaagctaag caagaatagg agatggatcc accatgcgat atagaaaatc accgccgcgc 3245581 ctgttttccc gacaccgcta agcataaacg caatacctga ggcaattggc tcgctccaag 3245641 aaagcccatg ctcatgccaa atcagattca tcccgttccc aagcagaacg gtcagcatta 3245701 atcctccgat aaaaatgaga acgagtccgg ctttgaaacc gcgtttcagc ctcacgagct 3245761 tttcgatata acgtctgtag aatgcccacc caacagcaat taaaatgaga aacgtaacaa 3245821 tttcctgaaa aaaggtgaag gcgggataga ccgggccaag cgacagattc cggccgggag 3245881 ccagtccttt gatgataaag tcaattgctc cgaactgaac caatataaat ccgtagaaaa 3245941 acatgacgtg aatgattccg cttttcttgt ccttgagcag ttttttctgt ccgaatacat 3246001 tcacccatat ggcgtgaagc cgttccttga accgttgatc aaattgttct ttctggccga 3246061 gcttgatgta ggccagtctc gttttgacca agtaaacaaa caaatagaca gcgtaagcgg 3246121 ttacaatcag aaataataat gcatttgcga tgagaaagcc gctcattcca attccccctt 3246181 tttactgata aagaccgcga tcccctaccc ccgaatctgt ataagattat ctttatgata 3246241 aataatgaat gagtgttcag tcaataatta aattcctgct gttcgggcac actaccttta 3246301 ctacggaaag gagtgccggt atgaaggtat ttatcgtgat tatgatcatt gtcgttattt 3246361 tctttgcctt gattctgctt gatatcttca tgggccgtgc cggatacaga aaaaaggcgt 3246421 acgagcctgt tttttcaaaa aagaagagtg acatcgaatt gatccactgc ggcgctgatc 3246481 tcgttgagcg gatgatgaat gatattcgcc aggccgcctc ttctgttcac atgatgtttt 3246541 ttattatgaa aaatgatgag gtcagccaca atatgtatac cttgctgaaa acaaaagccc 3246601 aagctggcgt atccgtttat ttgcttctgg attgggcggg ctgccgggca attaaaaaaa 3246661 cggcgcttca gacgatgaaa aatgccggcg tccatgtcca tgtgatgaat cgtccccgtt 3246721 ttcctttttt cttttttcac atgcaaaaac ggaatcaccg gaagattacg gtgatagacg 3246781 gaaaaatcgg ttatatcggc gggtttaata tcgccgaaga atatcttgga aagaaggcga 3246841 agttcggcaa ttgggaggat tatcatctgc gcatgatcgg agaaggcgta catgatcttc 3246901 aaacgctttt tgcttctgat ctaaaacgaa ataccggaat cgaactgggt tcggatgttt 3246961 ggccaaagct tcagcaaggg actatttctc acaagatcta tgcgaccgac ggttattccc 3247021 ttgaaaacat atacttggcc aacattgccc aagcgaagaa tcgccttacg gtttgcacgc 3247081 cttattacat tccatcaaaa ccgcttcaag aggcccttat taacgcaaga aaaaacggcg 3247141 tatccgtgag aatcattgta ccgatgaaat cagaccatcc gctggtacga gaagcggctt 3247201 ttacgtatta ttcggagctc ttggatgccg gctgtcttat ttatcgttat tatcaagggt 3247261 tttatcatgt aaaagccctc atcatagacg accatctcag cattatcgga acagccaact 3247321 tcgataaacg gagcctgttc ttaaatgaag aggtgaatgt tgaaattgat gacgaagcgt 3247381 ttacaagtga agtctatgcc acaattgagg aggatatgaa aaagtcggag ctgctgacga 3247441 tggaggattt cagcaagcgc acattcaggc agcgcccggc ggaatggctc ggcagggcat 3247501 tatcttattt cttataaagg agagttccta tgattttcag attcgggttc gtttcaaatg 3247561 cgatgagcct ttgggatgcg tctcccgcta aaacattgac attcgcgcgt tattcaaagc 3247621 tttcaaagac tgaaagaaaa gaagcgcttc tgactgtgac aaaagccaat ttgcgcaata 3247681 cgatgagaac ccttcactat atcatcggcc acggcattcc tttgtaccgt ttttccagtt 3247741 cgattgtgcc gctggctacg catcccgacg tgatgtggga ttttgtaaca ccgtttcaaa 3247801 aagagtttcg ggagattgga gagcttgtta aaacccatca actgcgaaca agctttcatc 3247861 caaatcaatt cactctgttt acgagcccga aggaatccgt cacaaaaaat gcggtaacag 3247921 atatggcgta tcactaccgc atgcttgagg ccatgggcat tgctgatcgc tccgttatca 3247981 acattcatat tggcggcgct tacggaaata aagacaccgc cactgcacaa tttcatcaaa 3248041 atataaaaca gctgccgcag gagatcaaag agcggatgac acttgaaaat gatgataaaa 3248101 catatacaac ggaagaaacg cttcaggtct gtgagcagga ggatgttccg tttgtctttg 3248161 actttcatca tttttacgcc aatccagacg atcacgccga cctgaatgta gcactgcccc 3248221 gcatgatcaa aacgtgggag cggatcggcc ttcagccaaa ggttcacttg tcttccccaa 3248281 aatcggagca agcgatacgc agccacgccg attatgttga cgccaacttt ttgctgccac 3248341 tgttggaacg ctttaggcaa tggggaacta atattgattt catgattgaa gcaaagcaga 3248401 aagacaaggc gcttctccgc ttgatggatg aattaagctc catccgcggt gtcaaacgca 3248461 tcgggggcgg tgcgctgcaa tggaagtcat aaatgtgcaa aaataggttt acgacttgtc 3248521 agctttggga acttaggcta tataagacaa caatcgatgg aggagaaaga tcatgaaaaa 3248581 tatcaagtct ctgaaagtag ccgcacaggc ctttacttta agaaatttga ttcatcttta 3248641 taaaatgtgc cattccggaa gccacgaggt ttatatttat tcaaagaaaa cgatgtgcaa 3248701 aatcaaaagc ttaattgagc ttgaaacgtt ccgcatggct cataatgaaa aggaatatct 3248761 gatcgtagtt gaaggaacaa aagcatcaca gctcattgaa aaattccaaa atctcatcga 3248821 gcctgctgag agagaagcgc tctaacttac atacaaaaaa ggatagacat ctgtctatcc 3248881 tttttcttat gctcttacat aatggagctg aaccgcttgt ccaaattgtt ttgtcccttt 3248941 taaccgcagt tttgtttcat ttgttagttc gtgaaacagc gggatgccgc ttcctaaaac 3249001 gacgggaata acagtgatga tgaattcgtc gatggcatct tctttcataa agtcattcac 3249061 aagctctgcc ccgccagcta tccagatgtt tgagcctttt tcctgtttca aacgggcagt 3249121 gaaggctctg gctccctcat tgataaacgt cacatgttca tcttgataac tgtcgggcga 3249181 tcctgtaaaa acatagcagg ttttatcctg atacgggaaa accggtgtta gcactttaac 3249241 gtgctcatat gtgctccgcc ctaaaatgac tgtatcaaca gtctgataaa aatcactgta 3249301 gccgttgtca ccttcacctt caaattcatc cagccaatcg atgcttccat cttcttttgc 3249361 gatcatcccg tccaatgaaa cagcaatgta cagcacagtt tttctttcca tgttctcctc 3249421 ctatcgatgc accatttgcc cgaattgcgc ttgatgcagc ctgctgtata ggcctccggc 3249481 ttcgatcagg tcttgatgac ggccttgttc ttcaataccg ttgtttgtga cgactacaat 3249541 tctgtccgcg tctttgattg ttgccagcct gtgggcgatg acaagcgtcg tgcgcccctc 3249601 agacaactct tgaagcgcct tttggatcgc cgcttccgtc tctgtatcaa gggctgaggt 3249661 ggcttcgtcg agaatcaaga tcgacggatt tttcaagaac atccttgcaa ttgacagacg 3249721 ctgtttttgc ccgccggaaa gcttcacgcc gcgttcgcca atcatagtat ccaacccatc 3249781 gggcatgtta tggacgagct cttccagatg cgcctgcttc acagcttgcc aaatgtcttc 3249841 ttctgatgcg cctagtcggc cgtaggcgat attttctcta agcgtgcccg agaataagaa 3249901 aacgtcctgc tgcacgacgc caatctgccc gcgcaacgaa gaaagcgtca tgtcttttat 3249961 actgatgccg tcaatcgtaa tgtcgccctc cgatgcttca taaaaacgcg gaagcagact 3250021 gcaaagcgtt gatttcccag cacctgacgg accgacgaac gccaccgttt cccccgcttg 3250081 aatggatagg ttgatgtcat tgaggacatt gtgatggtca tcatagccaa acgaaacatg 3250141 tttatagcgg atattgccct tcaggccgga aacatctttc gaatcaggtg agtcctgaat 3250201 atccggctct gtctccatga gctccatata gcttttgaaa cccgcgatcc ccctcggata 3250261 catttcgata atggcattaa ttttgtcaat aggcctgaac agcacattcg tcaagagtac 3250321 aaacgccaca aattccccgt acgataagga gccgcgaatg acaaaccacg tcccgcacaa 3250381 aaggacaaac agcgtgacaa accgggtcag catatagctg attgaaccgt ttttcgccat 3250441 gattttgtag gaagaaagct ttgtgacacg aaaacgctgg ttgttgacgg cgaagcgttc 3250501 tttttcaaat gcttcatttc cgaacgcctg cacaagccgg atgccgccga tgttattttc 3250561 tacacgcgcg ctgaagtctc cgatatcctt gttcagcgtg gtaaatgctt tggtcatttt 3250621 tttgttgaaa taaagcgcta gccaaatgac gatcggcata atgataaacg ttaataaagc 3250681 aagctgccag ttaataaaca gcatcactcc gaacgccccg agaatggtca tgaccgcaat 3250741 gaataagtct tccggtccgt gatgggcgac ttcaccgata tacattaaat cgttcgtgag 3250801 cttcgacatc agcgttcccg tcttgttgtt gtcgtaaaat ttgaacgaga gcttttgcaa 3250861 atggtcaaaa agcgactttc tcatatcagt ctcaatattg ataccaagca tgtgtcccca 3250921 gtaggtcacg atatactgaa gagccgagct gagcgcgtac accgcaaata acccgattga 3250981 ggtcgcgatg atcagtcccc agtccctgcc cggcagcaag gtatcaataa aataattgac 3251041 gatcaaagga aaactcagct ccattaaacc tcccgcgatc gctgagaaaa agtcgagaaa 3251101 gaacaacgtt ttatatggtt tataatatga aaaaaattgc cgcagcaccc tatcttcccc 3251161 caatgtataa ataactgata atatttctca attatactat acacgggctg ttttgtaaga 3251221 tcagatttct tttttcttac agaacacctg aaaacaggcg ggcaaacgac tcttttgtcc 3251281 ggtcagccac acctctttta taaaagccga cagggctgag cttttcactt tcctgcatat 3251341 cctcttcaaa atgggcctca agggttcgga tcgcttcggc atccgtgaag aacacattca 3251401 cttcaaagtt gagctgaaag ctgcgcatgt ccatattcgc ggtaccgacg gaggcgagat 3251461 cgccatcaat gatcatgact ttttgatgca tgaagccttt ttggtaggag tacacttcaa 3251521 tgccctcaag gagcagctcc gggaaatagg acctcgacgc gtattgggtc aaaaagctgt 3251581 cgttcttctc cggcaccata acccttacct ctaccccctt tgtcgccgct gcttttagcg 3251641 ccgtgcgaat ggattcattg gggacaaaat agggcgtggc gatccatatt gatttctgcg 3251701 ctgaagaaat catttcataa taaaggtcgc tcatgctttc cttcatgtca gggcctgtcg 3251761 cgacaatttg ataaatgcct cctccttcca cgggaaccgg ggtattgtac tcctcttgat 3251821 caattagcac ttcattggag acatattccc aatccagcat aaagatagcg tggagcgttt 3251881 gcacaatttc cccctcaagc cgcaggtgtg tatctctcca aaatccgatg tacggatctc 3251941 tgctgatata ttccttcccg acatttaatc cacccacaaa accggttttc ccatcgatga 3252001 tcacgatttt ccggtgattt ctgaaattca gcttctggtt gaaaaacccg tatttcagcg 3252061 gagaaaacgg gacgatgtcc acccccgctt gtttcattct cataatatct cttcttgcca 3252121 gcttcatgct tcctgccgca tcgtataaaa acctcacctc gacaccctgg cgcgctttct 3252181 ccatcataat atccatcatg ccgcgtccga gcatgtctga tttaaacatg tagtattcaa 3252241 tatgtatgta agattccgct tttctcattg ctttgaaaat gtccgggaag gtttcttcgc 3252301 cgtttttcag cactttgatg ttgcttttcg tattgatatt catatgggca gccctgatgg 3252361 aatatgtaaa gaacctctct tgattgtcct tcagccctgt cacttcgggc gtttcctcct 3252421 tgtcaaacag cttcctgagc ttttccctgt tgtacattcg ttttgtctta aacagctttc 3252481 cctttacata aagctgtccc gaaaacagat aaaacacgta gccgacgatt ggaaaaaaga 3252541 caagaatatg gatccatagc agcgtgtgct gcgaggtgcg gttttcaaga attaatgaat 3252601 agatgctgaa caaaataatg cttatatagc aaagcaatcc tccgtaaaac tcaagtctgg 3252661 aaaccggaaa aaaccaaatg acatatgccc cgatgagcat catatataaa aagaaaaatt 3252721 ccagtctcct tttcagcatc ctgattctct ccaatctgat tcaattacct ctgtattacc 3252781 tcttttttct aatcgataaa ccttgtaagt aaaaaacctc tccgccaaag gaggagaggt 3252841 ttagagaaaa ctaactgtca cggaattcat ccgcatcgtt tctgcagaaa taaagcaaga 3252901 ctattggcaa cgccgagtga caacatgagc ggcaagctga acccgctcag cactccggca 3252961 agcgccgaaa agaaggcggc gctgtgactg caaatacggt ggatagagta aatttgatac 3253021 ccattctgat gagagaaaat atataaaacg ggaaattgat cagaaagata taaggagtta 3253081 gtcaggctga atcataatct ggctgttccg ccggtttaaa atgagtaaaa tccttgatgt 3253141 tatttccata tacaaacata acaggattcc cggcagccca gccattacct tggcagaaaa 3253201 aaccccctct tgcaaggggg attttcacga gcgtttccga tatacaacgt agctgcgggt 3253261 cagatacttg agcggcagac tgaacacatg aaccaatctc gtaaacggcc acaggataaa 3253321 aacgacgtat cctatcacaa tatgaaactt aaaccatagc gggacactct ccatcaaaga 3253381 ggcgtcaggc ctgaacaaaa cgatttccct gaaccagggc ccgactgtgg tccggtaatc 3253441 aaatcctttc gaatcaatgt tgagaaacgt ggccgcaacg cctgacagca tcatgaacag 3253501 cagcaggagg agcgtaagga tatcggatgg cgagctcgtt ttgcggattc ttttgtcaaa 3253561 cagccttctg tacgtcagga tgacaagtcc ggtacatgcc gcaatgcccg ccggcaagcc 3253621 agcgccaatc gccattttgt gatacatatg ctctgaaatg ccaagggaag catacacgcc 3253681 ttctgggatc agaatcccca tgacatgccc gccgacaacg cacagcagtc cccagtgaaa 3253741 aagtgtgctg ccagccgcaa gttttttctt ttctaacagc tcgcttgatt tcgccgtcca 3253801 gccaaattgg tcatgctgat agcggtaaat atggccgccg ataaagattg tcaatacaat 3253861 gtatggcata ataccccaga ggatctgccc gctcatgcct gaacagcccc ttcaacgctt 3253921 tcacgtacgc caatgttttc aagcgcggcc agcagcacgt gcagcagttc agcgtatata 3253981 ctgtcatttt tttcgagacg ggatgccagc tccctcacat tggacagata tttctcaaac 3254041 acgcttctcg ctgcttcaat ttctgcagcc gcagcaaatt ccagcatcag cggcagataa 3254101 tcaggcagct ctttctctgt cggcaggaaa ccggattgct cgtatgtgtt ttttaaatgc 3254161 agcaattcaa tgccgcgttc cctttgctcg cctgagttaa agtaggtgac atacatattt 3254221 gtttttttcc cgaagtcgaa tgtatagaca tagtgttcaa tcagcgcttc cggagaatag 3254281 ctggctgacg tctcgaaaaa gtgcagcagc ttctcccgga tttgccggtt gccgatttct 3254341 tggataagag ccttccaatc gggaagctcg gctctccact cttcatccgg ataagagaga 3254401 agacaggaaa gagcagagaa cgtgatttgc cggtctgtgg tgttcatctt gttacacctc 3254461 atttatcaaa agttagaaac aggagccggg gccgcctgaa aatgataagc cgcagcttcc 3254521 ttgttcagcg tataaatctg atacttcttc tcgatggctg ctcggaatca caaagcggtc 3254581 atcatatttg gcaatcgcaa gcagccgata catatcttca atttgctgtt ctgttaagcc 3254641 gacactggag atcagttccg gatcgattga tttattcgtc tggaccgctc tcatatactg 3254701 gcgcatgaca gacattttct ttaatgttga ccgaatatga tccgtatcac cggctgttaa 3254761 cagctgcgcc aaataatcta tcgggattct catttggtcg atagccggaa aaatatcttc 3254821 cgccgtttgc cggctgcctt ttccttcaaa gagattcata atcgggctga gcggcggaat 3254881 gtaccacacc attggcagcg tgcggtactc aggatgaagc ggcagcgcga tcttccagtc 3254941 aatgatcatt ttatagatcg gtgattgctg cgcggcctct atccattcag ccggaatgcc 3255001 ttgttctttt gccagtttgg caacctcagg atcattcgga tcaagaaaaa cgtccaattg 3255061 ggaatggtag agatcctttt cattttcaac agatgccgct tcctccactt tgtccgcgtc 3255121 atatagcatg acgccgaggt agcggattct gccaacacac gtctcagagc agatggttgg 3255181 cagtcccgcc tccaaacgcg gaaagcagag tgtgcatttt tccgctttgt tcgtttgcca 3255241 gttaaaatag acttttttat aaggacagga tgagacgcaa tatctccatg aacggcatgc 3255301 gttttgatcc acaagcacaa tgccgtcctc ctcgcgtttg tacatggcgc cggatggaca 3255361 ggatgagacg catgccgggt tgatgcagtg ctcgcaaata cggggcaaat acatcataaa 3255421 gacgtcatcg aattctgttt tgatcgattc ctccatcttt tgtacgttgg gatcttcaag 3255481 tcccgtaatg tggccgcctg cgagatcgtc ctcccagttc ggtccccatt cgatattcat 3255541 gaaatccccc gtcaaggacg atttcgggcg tgctaccggc tggtgttttt tctgcgggct 3255601 gttcgttaat gtttcataat catagttcca aggttcatag taatcatcaa ttgacggctg 3255661 attcggatta tagaaaaggc ctgcaagccg attggttttc gagcccgatt tcagctcgag 3255721 ctttcctttt ttcaatgtcc agccgccttt atatttgtcc tggtcctccc attgcttcgg 3255781 gtagccgatg cccggctttg tttctacatt attgaagtac atatattccg caccggaacg 3255841 gtttgtccac gtgtttttgc aggtgacgct gcacgtgtgg cagccgatgc atttatccaa 3255901 gttcatgacc ataccgattt gcgctttaat cttcaagcca atcgacctcc ttcagcttgc 3255961 ggatgacgac gttcaggtcg cgctgattcc ccgttggacc gtaataatta aagccgtagc 3256021 tgagctgggc gtagccaccg atcatctgtg tcggcttgac gtgaatcctt gtcgggctgt 3256081 tatgggtgcc tccgcggtta ttcgtcagct ttgtgccggg cacgttgatg tggcggtcct 3256141 gggcatggtg cataaacgcc attcctttag gaatccgatg agacaaaacg gctctcgcga 3256201 cgacaacgcc gtttcggttg aagcattcaa tccaatcgtt gtctttgata tccgtgtcct 3256261 ctgcatcatc tttattcatc cacacggtcg gcccgccgcg gaacagcgtc agcatcggca 3256321 gagaatcaaa atacatgctg tggacagacc atttattatg cggcgtcaaa taattgagga 3256381 cgatttcttt tccctcttga tcaggccgtt tgctcagaaa cgggcgatgc tggaggatcg 3256441 gtttgaatgt cgccatcgtt tcaccgaatt ccatcatcag ttcatgatcg acataatagg 3256501 attgtctgcc tgtcagcgtc cgccacggaa ttaatttttc aacattcgtt gtaaacggcg 3256561 aatacctgcg ccctcctttt tcagagccgg taaacgctgg agacgtgatc accgttttcg 3256621 gctgggctgt aatttgttcg aacgtaaagc attcttcctc gcgttcttcc gccaggtctt 3256681 tcagcttcag gttcgtgatg ttttcaagtg attcccatgc ttttactgcg acctttccat 3256741 tcgaagtgga tgatagggtt aaaatcgctt ctgcagcctg ctttgcttca cttatatttg 3256801 gacatccctt tgccacgctg tccgaggtga tttctcccag tctctgtttg agtgattcat 3256861 attcatcggc tattgaccag ctcatccctt ttgttccgct cggctttaaa gcaacgttcg 3256921 gaccaagtgc agtcatttta tgaaaaatgt gtttgtaatc ccgttcaacg acttggatgt 3256981 tcggcatcgt ttttcccgga atggcttcac attcgccttt gctccagtca ttgattttgc 3257041 cgaatggctg ggccaattcc tgcatggtgt cgtggagcag cggtgtcgca accacttctt 3257101 tcaccggctc catatcgact tcttctgcca gatcggaaac ggcttttgac agcgccttga 3257161 aaatatccca gtctgacttc gattcccacg gagccgagat cgcaggagca aatggatgaa 3257221 tgaacggatg catatctgtg ctgctgagat cgtgtttttc ataccatgtc gccgccggca 3257281 gcacgatatc ggaatacagc gccgtacccg ccattcgaaa atcaagattg attaataagt 3257341 cgagctttcc ttccggcgcc tgctcccgcc atttgatttc ttctgggcgg atgctgtcgc 3257401 tgtcgtcatt cattaaaccg ttcgttgtcc ccagcaaatg cttgagaaaa tattcatgcc 3257461 cttttcctga gcttgagatc agatttgccc gccatacaaa gagattcctt gggaaattca 3257521 cttcattgtc aggatcttca atcgcgaatt tcagtttttt ctcttggagc tgtgaggcca 3257581 cgtacgcacc tacgtcttca ggtgttgctg cccctgcttt ttcagcttct ttatacagat 3257641 cgatgccatt ttgattgaaa gtcgggtaag acggaagcca ccctagccgc gccgccagca 3257701 cattgtaatc agcgtggtgc ttgtagcggg atgaagcagc aatcggtgat gccaaatcac 3257761 tgatcggctg gtcctcataa cgccactgat ctgtcgcaaa gtagaaaaat gaggtgccat 3257821 tttgcagctt gggcacgcct tcccagtcct ttgcagttgc aatcgtctgc cacccttcag 3257881 caggtcggag cttttcctgc cccacgtaat gggcccagcc tccgccgttt acgccttggg 3257941 cgcctacaag taaaacaaga tttaacactg ctcggtagat cgtgtcggag ttgaaccagt 3258001 ggttaatgcc ggcccctacg ataatcatgg accggccgtc tgtatcgatc gcattttggg 3258061 caaactctct ggcaatctta acgacagctt cttttttgat tcctgtcatt tgttcctgcc 3258121 aggcaggcgt aaacggctca gggtcatcat aggagacagc cgatcgttcg ccgatgcccc 3258181 ggttcacgcc gtagttagcc agtatcaagt caaacacggt cgtgatgtac gtttcttcac 3258241 cgttcaggtt cattttttta ataggaagat cccgctcgag cactttgttt ccgtcatttg 3258301 aaaaatacgg gatgcgcacc gtgccgattt cgtcctctat tcccagcaca gagagacggg 3258361 gttcaatcgg ttccccggtt tcttcatcaa tcatgtgcag gttccatttc tgctgcccgt 3258421 cccagcgcga gcccattgtc ccttggggta tggcaaatga acttgtctgt tcatcccaaa 3258481 ccgcaggctt ccactgatca tgctttgtct tccgcccgat gtccttcgca tgcagaaacc 3258541 gtcccgctgt gtatacgcca ttttcttttg acagagtgac gagaaatgga aaatcagtgt 3258601 attgcttcgc gtactcaata aaacgttcag tttcttggtt cacgtaaaat tcctgcagaa 3258661 taacgtgacc catcgccatc gcaagcgccc cgtcagtccc ttggcgaata ctcagccagt 3258721 catccgcgaa ctttgaggat tccgcaaaat ctggactgat cgaaatgacc ttagcgcctt 3258781 tatagcgggc ctccgccaaa aaatgcgcgt caggcgttct cgttaacgga acgttggagc 3258841 cccatgtgat aatatagccg gaattgtacc aatcactgct ttccggaacg tccgtctggt 3258901 caccccaaat ttgcggggat gctggaggaa gatccgcata ccagtcataa aaactgagca 3258961 tagggcctcc gattaacgac ataaaccggg agcctgatgc gtggctgatc atggacatgg 3259021 ccggaatcgg agaaaaaccg acgtttcggt caggcccgta tttcatcact gtatacagca 3259081 gagaggctga aatcagcttc agcacctccg gccattcagc gcgcacaaaa ccgcctttcc 3259141 ctctcgcctg tttataggac ttcgcttttt cagggttttc gacgatcgat ttccaggctt 3259201 ccaatggatt ttgatgcgtc tgcaatgcct cccgccacaa attgatcagc acaccgcgca 3259261 cgtatggata tttcacacgg agcgggctgt agatatacca tgaaaaactg gccccccgcg 3259321 ggcagcctct cggttcaaaa tcaggcatat ccgggcctgt tgatggataa ttcaaatttt 3259381 gcccttccca cgtgactatt ccgtttttca cataaatatt ccagctgcaa gaccctgtac 3259441 agttgacgcc gtgggtggag cgaacgactt tgtcgtactg ccatctgttt ctgtatacat 3259501 tctcccaatc gcgatcctcg cgggtagttt ggctatgttt atttgaatgg tgttcgatag 3259561 gagagaaata attcaatctc ctaaacaacg gactcctttt ctttttcttc atgagagttc 3259621 actccttccg agtcaggtga tgctaagttc actataaaca gagacagcgt gtttccttgt 3259681 gaactatgtc acacactctg cttttttcac aaaatgttca cacaaaggag aaggaaggct 3259741 gcgttcaggc aggacgcttg ggtcattagc tgcctttcat tcaaagatca aaaaaaaccg 3259801 gctctattta agaaccgggc tcagcgtttt catcctgtga tgtatgcaga taccgcaaaa 3259861 ataattgata ggaacaaaaa acattttgct gaagcatagc caaaaagttc atttgcagct 3259921 gcggatgata agacatcatt ttcttaaata tgtaatatgg gatgttgaga atcagaatgt 3259981 ctgaagtggc attgactgag ataaagggcg ataaataaag cccgcctttt tcatcaatcg 3260041 gaaacacatc gcctttttcc cacagcgcaa cggttttcga cccttcaggg agccttgtgt 3260101 ccataaaacg gacactgcct tttaatacaa tataaacaga ttgagaatga agaaaagatg 3260161 gagactgatc acatgaaccg cggataaacg tgccgttttt cagcaaggtt tcgacaatgg 3260221 atagaggcac ttcattaaac ataggaagtt gtttcagaaa taataaatag tcacactgat 3260281 tcataggaaa acctcctgtg ctaaggatag ctttagtgta gctcgactga gcctgtacag 3260341 cagtgatgta tttcacagcc tgtatgatga atgtcactta tcaggagggt gaatgcattt 3260401 ataatgaaag aaaaaaggag gatttcgatg aaggcgctga ttccgaagca gcacggggcg 3260461 tgggcgatgc tgctgatccc atttttactc ggcatggtca agggaggccc cgttatttgg 3260521 catattccgc tcttccttgg ttggcttttc ctatacttag cggtttatcc cgttacgctt 3260581 gccttaaaaa agaaacaaag caaaccatat caaaagtgga tgtgttatta cggttttccc 3260641 acctgctgct ttttgatgat ctcggtcttt cataagccgc ctctcatctg ggtgggcgtt 3260701 tctttactgc cgctgtttct catacatatg tattttgccc gcagaaaaaa cgaacgagcc 3260761 ttattgaatg atgttgcagg tgtcttgttc ttttgttcgg gcgggtttgc gagctgctgg 3260821 ctggggatgg gaacccttga cggctgggct tggtttattt tcttgcagtc tgctttattt 3260881 tttatcggga gttcctttta tgtgaaatcg gtgatccgcg agagaaaaaa cagggcattt 3260941 gcatactggt catggggata tcacctgctg ctcccctttt tatccgctct tttcggagca 3261001 ggatgggcgt ttctcgcttt tatcccgagc agcttgcggg catggttttt tcatggaagg 3261061 gattggcccg taaaaacgat tggcattctg gaaatcgtga atgcctgctt ctttcttgcc 3261121 gtcatgtgcc tgtttatcac aaggtaaaaa aacaaggaca ccgctgtcct tgtttttttc 3261181 agtcaatatt gcaaatctcc agcgggcaat tttcacactc aatctcacat cgtaaatagt 3261241 cccgcttgtg caaaataatt tttccggatt cgtctatcga aataacccct tttttgcgga 3261301 gatctccgag catacgattg acgctttccc gtgcagccgc gcaaaacttt gccaaatcct 3261361 gatttgtcag gacaatgtta atcagaatgc cgtcgcttcg ctccactccg tagctgtttg 3261421 ataagcggat aagggtagaa tagagcgccc cctttttgcc atgaagaagc agatccctga 3261481 ttttggactg aatcttccgg aggtgcgtgc tcatccattt catgaactca aatgtcaaag 3261541 cgccgttttg gattaattct ttttccagct tatttttatt aatgacgagc acctcgccat 3261601 cctctagtac ttttgcactg agcatatacc ttggttcttc agtgaaaagt gttaattctc 3261661 cgacgatatc atgcttttgg cagattctaa gcgtcaggtc ttttccgtca gatgtcagct 3261721 tgccgatttc aatgagtcct gattgaatca gataaagctc ttctgcatcc attccttccc 3261781 gaaacaaata cgtgtgtttt tccatttttc ttttcgtgct gatcgattcc agcaattcat 3261841 acagatcgct ggatataaga tcactatcag atggtcgaac agagagaaaa ttcatgagct 3261901 cacctcgaag aaagtcacgt tgtgtgttta ttgtaacgtg aattgatttg tacccatcga 3261961 gaaaaaacta acaatcttgt gaatgcccca gtgttagttg atgctctggc tgtttctctc 3262021 cgtgtgtgtt ttcattcttt cctgccaata catccatatg acaaggacaa aactggctaa 3262081 cgccacctct gaaagcgcca taaacccgat cgcgtactgg cctgttgcct gaaatacact 3262141 cgccaatatg agcggaggaa aaaagccgcc taaaccgccc atggcagaca caatcccatt 3262201 ggcaatcccc gcttgcttcg aaaaatagaa aggcaccagt ttaaaaacag ttccgtttcc 3262261 tatgcctgag cagacggcca cggttaatga tccaaacgta taaaggccga ttgtcggcga 3262321 gaacgatagg ataatgcctg ataatgtaag cccggcaaaa acaaacatca agatgcggag 3262381 cgggctcatt ttatcagcca ggaatccgcc cgcaggcctg agcagcgtag aaaccgcaat 3262441 aaagccagcc gtccgcaagc cggcatctgc aggattcagc ccaaaatgct ccaccagaaa 3262501 gttcggcaga tagatagtga aggcgacaaa ggcaccgaac gtaataaaat aaaacaggct 3262561 cagaaaccat agcacatgat ttcggtaaac agctttgatt tgagtcttaa cagaaacttt 3262621 gaccttcttc tcatgcctgt cgccaaacaa tacgtgcagt aaggcaaaga cagccagcaa 3262681 aatcagatac atttgcacgg ttgatttcca cccgacggct tgagcgataa ccggcgctgc 3262741 aaatgtcgta acggctgtcc cgatatttcc tgcaccgtaa atcccattga cgacaccgtg 3262801 cttttctttc ggataatatt tcgggaggga ggtcacccca atggaaaaca ccgctccccc 3262861 gatccctaag aaaaagccgc ctgcgattaa atcaaacaga gaatccgcga tactgatcca 3262921 aaatacagga aataaaagca ggatgaagct gaccataaac atgagccgcg cgccaaacct 3262981 gttcgttaaa taccctaaag gaatgcggag aagcgacccg aggatcacag gaatcgcggt 3263041 cactaaagaa atctcaccct tgcttaaatg aatatctaat gtgatttggg aaatgagtga 3263101 tgaaatcagc acccaaacca taaaccctgc caccaagctt aatgactgta acgataattg 3263161 aatgtgttga cggttgatca tttggcttgc ccctttcaat gattcaataa tcagtcttat 3263221 catacaaaaa ctagccaaac aggattgtga attacatcac acgtttttct cataaaaaaa 3263281 ggacaaagcc cgaagacttt gtccttttga tcgtgattac attttttccg gagccgatac 3263341 gccgatcagc tgaagcgcat tgttcagcgt aatttgcgtt gccttcatta aagccaggcg 3263401 cgcgcggctt ttctcttcat tttcagggtc gatgactttc tctgcgttgt agaagctgtg 3263461 cagagcagaa gccagatcat aaatatagtt agtgacacgg tgcggaattc gtttttccgc 3263521 tgcttccgcc actgcctctg ggaagccgcc gatcgttttc agcagatcgt attctttttc 3263581 tgattgaata tggctgaaat caagatctgc cgccggttta agcccctgct cttccccttg 3263641 gcgaagcatg ctgcaaatac gggcatgcgc gtattgtgca taatacacag ggttttcgtt 3263701 agatgttgat acagcaagat ctaagtcaaa atccatatgg gtgtctgcac ttcgcattgc 3263761 aaagaagtaa cgcacggcat ccaagccgac ttcttcaatc aggtcacgca tcgttacggc 3263821 tttaccggtc cgtttgctca ttttcatttt ctcgccgttt ttgtaaaggt gaacgagctg 3263881 aatgatttct acttcaagcg ttcctttttc atagcccagc gcttcgattg ccgctttcat 3263941 acgcgggatg tagccgtggt gatcggcgcc ccaaacgttg atcagcttat caaagccgcg 3264001 gtcaagcttg tccttatgat acgcgatatc aggaagaagg tacgtgtacg tgccgtcctt 3264061 cttgatcaat acgcggtctt tatcatcgcc gaaagtcgtg gaacggaacc aagtcgcgcc 3264121 gtcttcttca tagacgtggc ctttttcgcg gagcgcttca agcgccttgt cgatttttcc 3264181 attttggtac agtgaagttt ctgaatacca cacatcaaac ggcacacgga agttttccaa 3264241 gtccttgcga agcttttcca gctcgtattt caggccgtat tcacggaaaa acgcgaggcg 3264301 ttcactttcc tcttcgttaa cgaaacgatc accgtattcc tcagcgagac gctttccgat 3264361 cgcaatgata tcctcaccgc ggtagccatc ctccggcatc ggtttttcca atccgagtgc 3264421 ttcaaagtaa cggacttcaa cagaaagcgc cagattgttg atttggtttc ccgcatcgtt 3264481 aatgtagtat tcgcggctta catcgtaacc cgcttttgaa agcacgttgc acaaggaatc 3264541 gccgacagcc gccccgcgcg catgcccgag gtgaaggtct cccgtcggat tcgctgatac 3264601 gaattctacc tgaactcgtt caccgtttcc gatgttcgtt tccccgtatg cttcccctgc 3264661 ttccagtaca gacggaatca gctttgttaa atattgattg ttcatataga aattgataaa 3264721 acccgggccg gcgatatcca gtttttcaat cgaagccttc cctttatcaa aatgggcgac 3264781 aatctcttca gcgatttgac gcggcgcttt ttttgccact cttgccaact gcatcgccat 3264841 attcgttgag tagtcgccgt gtgttttatc tttcggtgtt tctaaaacaa cattgggaat 3264901 ctggctttct tcagccagtc ccgctttcag aacggccgct ttgatttctt ctttcagcac 3264961 gtccttcatt tgttccgcaa tgttcatgcg tgagttcctc cctcatacgt gatcgtcata 3265021 ttatgtaaat gctcctgctc gtctccgaca tgcatgtcat atgcgatgct gatacggcct 3265081 ttttcttcat cgagatcaga ttgaatcgat tttgtgcttg ttttcagctc aagctcacca 3265141 aatgacattt tatatttagc aattgtggaa gctcccgtta cgaaacgctg attcattttg 3265201 acagcgcctg acctcatgac caggacttcg ccttcgctta ctttcacaat cgttttgact 3265261 ttgcctaagt cgtgttcttc ataataagat agatacactt tattttgttt tacatagtaa 3265321 aatccggtgg tgcggaattc gatgacttct tggtttccgt catcctcgat cacagacttc 3265381 acatggagtg ttatcggtgt ctcttgcttc attctgacac gtccttttca tcattccact 3265441 ttgacttgaa tagtataatc attcggtttg taaacttcaa ctgcttctat cttaccatca 3265501 ttgctcatca gatttgaaga taaacctcat aaaaagcatt tccttatata gaagagaaaa 3265561 tcatatcact aattaccttt aggaaatgtt acgagctcgc tacatcgcaa tcgcagacgg 3265621 acccgcgcca accggaatca ccgtcacggc tgtataatca cttgtgcggt acacggtcac 3265681 agcattgtcg ttgggctgtg ccgcataaat atactgtttg tccggcgtta cggcgaggtc 3265741 aaaggcgccg gggagagaca cgtttgcaat gatcctctgt ctggccgtat taactacgta 3265801 taagttatta atgagaaacg gttcactata tggctctaga aaataagctc tagtactatc 3265861 gagagaaaat acaatcgtcc tcagcgtttc aaataaacgg ctgaagtccc ctcccctgct 3265921 taatggtgac aaactaatct ccgttacacc tttcggccac agctcaccat tcaatacgta 3265981 cgcaaaattt ccagcgtaag gagttgtaat taaactggga aattcaaatg tatctatgat 3266041 actttctacc aactgcccag tatttacatc atatttatca accgaccaac tgcttccatt 3266101 agcggtatag acatactgtc cattcggatc aagagcaaag tctaaagcgc cgggtatcgg 3266161 aatgacatca atgaccgatt gagaggccgt gttaatcaca tatatagatc cggcggccat 3266221 cacgtatgcg aactcatctg ttggatcaaa ttcgattttt ctcggccctc ctccaacagt 3266281 aatggtattt atgatggtta atgttttatt atcaatcact gagacaaggt tggtatttcc 3266341 atggaggaca tacgtgaatg ctttatcgaa agtaacgcct agattagttg gcacgtcaga 3266401 aaaagggatt gtttttacaa cagtgtttaa atctgcatca ataaccgaaa ccgtgctgtc 3266461 tccagtattg gcagtaaaca catacgattg agggtctggt gatggcggta aaacaagtgt 3266521 cccggccacc gtaagcggac tgccgtagaa aggcggtaca atgagcagat cttccactgt 3266581 tatttgactg aaatcaggac agcggccaga ctgtgctgca taataaacaa cttgatcaat 3266641 ctcttcagta tgaatcacag aaacagcccc gtctccttgt ccatattgat ttcgtacagg 3266701 cgacacactg acaagaagcg taatggtccc ttgtactctc acagcatatc gaacaccgat 3266761 atcttctggt tccggcccag tctggattaa gcaaggctca ctgatacagg acaaattgtc 3266821 tgtactccat gtaacagccg ctgacgcttc ggccgtatca accttgaagc cctcagggaa 3266881 atctatcggc acttgaaacg gcgcttcccg gctaatttcc tcatcacaaa aacagaaaca 3266941 attttcctgt aaagcagaaa gatcattctt tttcatgatt tcacgtcctt ttagaaatgc 3267001 acaacatgca gcggttaaat cgtaatggca cccggtgaaa ccccaagaga tatcacagtt 3267061 tcctcagaat aatcatctgt gttgtaaaca atgatgctct gctctataaa acgagttgca 3267121 tacagaaaat cgccattcgg ggtaaacgca tagtctgttg ctgattgcgg aacatttcct 3267181 ataacgcctg ctccatttgg actgacagaa tataaattgc cagtgaagcc gtcatataaa 3267241 tacacctctg ctccactcgt aaacattcga tattcccctt catactccag ctcttgggtg 3267301 ctgctgatgg taaacgtatt taaatcaata accgtcaaat aattaaaaaa gaattcttgt 3267361 tctaatacat aggcataccg ctccggccaa tttgtttcta tggttgatac gataagctct 3267421 cgttcaattg ttcctgtgac ttcaccggta gttaggtcca ctttttgcac tattccaaaa 3267481 ttcagaacat aggcgaataa cccattggga tcgattgcaa catcatatcc ttccacagga 3267541 atcgacctat ccacagttaa cgtatcaatt ccaatcacat aaaccgcagt accggtgaaa 3267601 acataagcaa actcatgatt agggataaat ctaatcaatc gaggcggctg atccagcaat 3267661 atagttgctg tcactgttaa tgtgtcataa tcgatgacag aaatcacatt attgttggga 3267721 tgtaagacaa acacagcgct tttatctggc gtaatttcaa tacctgccgg attgtacgga 3267781 agagcaatcg ttgtcacaac agtatcggtg tttgtatcaa tcacagaaac tgattgatca 3267841 tttggattcg ctgtaaacgc gtagacgggt tccggctccg gtacaagcac aattgtcccc 3267901 gtcaccgata aaggactgcc gtaaaacggc ggaacaacaa caaggttctc aatcgtgatg 3267961 tcactgatat ccgggcaatc atccgattca tcggaataat agacgacttg atcgatttct 3268021 gcattgtgaa tgacggaaac agccccgtcc ccttgtccat attgatttcg gacaggtgag 3268081 acactgacga gtagcgtaac ggttccctgc aggcgcactg caaattgaac accgacctca 3268141 tcaggctcag gccccgtttg aattaagcaa cggtcactga cacaagaaag gctgtctgca 3268201 ttccacgtca cgtttgcaac agcttcagcc ggatcaacga caaacccttc aggtaattca 3268261 atcggtgctt gaaacatggc ttctcggctt gcttctccct cacaaaaaca taagcactct 3268321 tcttgttctg ctcctgcttt ttctttaaag gaaagcttgt tttttctcat tccttcactt 3268381 ccttttcaga catacactgc tcacgcagat ataacagaat atggaagggt aacgtgtttg 3268441 cttgtacaaa ttgctgaggg taaacgcttc tttttgaaaa tatatctcca aacatgcggt 3268501 gtaacgaaag aaaaaattgc ggtttttttg cgcttctcac aagaatgttg atgataaaat 3268561 atgacatata tagaattatg aagggaggga tttgcaaacg tgacaggtgt catatcttct 3268621 tcttccatcg gagaaaagat taacgaatgg tatatgtaca tacgccgatt cagcataccc 3268681 gatgcagaat atttgcgacg agaaatcaag caagagctgg atcaaatgga agaagatcaa 3268741 gaccttcatt tgtactattc actgatggag tttcggcaca acctaatgct tgagtacctt 3268801 gaaccgttag aaaaaatgag gattgaggaa cagccgagac tgtctgatct gctgcttgag 3268861 attgataaaa aacaggctcg tttaactggt ctgcttgagt actattttaa cttcttcaga 3268921 ggcatgtacg agctggacca gcgggaatat ctgtcggcta ttaaattttt caaaaaggcc 3268981 gaaagcaagc tgatattcgt taaggatcgg atagagaaag ctgagttttt ctttaagatg 3269041 tctgaatctt attactatat gaaacaaacg tatttttcaa tggactatgc acggcaagca 3269101 tatgaaatat acaaagaaca tgaagcttat aatataagat tgctgcagtg tcattcttta 3269161 tttgccacca attttttaga tttaaaacag tatgaggatg ccatctcaca ttttcaaaaa 3269221 gcttattcta tggcagaagc tgaaaagcag ccccaattaa tggggagaac tttgtacaat 3269281 atcgggcttt gtaaaaacag ccaaagccaa tatgaggatg ccatacctta tttcaaaaga 3269341 gcaatagctg tttttgaaga atcaaatatt cttccttcct tacctcaagc gtatttttta 3269401 attacacaga tccattataa attaggaaaa atagataaag ctcatgaata tcatagtaag 3269461 ggaatggctt attcacaaaa ggccggagat gtaatatatt tatcagagtt tgaatttttg 3269521 aaatctttat acttatcagg cccggatgaa gaagcaattc aaggattttt tgattttctc 3269581 gaaagtaaaa tgttgtatgc tgatcttgaa gatttcgcta ttgatgtggc aaaatattat 3269641 catgaacgta aaaattttca aaaagcttct gcttattttt tgaaggtgga acaagtaagg 3269701 caacttattc aaggaggagt gagtttgtat gaaattgaag tctaaactat tactctcttg 3269761 tctggctcta agcactgtgt tcgtggcaac aactattgca aatgcaccta cacaccaaat 3269821 tgaagttgca caacgaggaa tgatttaacc gccgtccatc ggcggttttt tcgtcccctc 3269881 tttaccaaag tctcccaatc catgctatga tcttttcaat aatcttgaag agagtggaaa 3269941 tgcagcatgt ctctaaaaag tgtgagaacc cactttactc aatggaatcg agaaaatgat 3270001 gtgacggagt tcgaaacgtc gagtgcgaca gttgaacagg cagctgagac aatcggcgta 3270061 agcctgtcta gaatcgccaa gtccctgtcc ttcagagggg aaggagatca ggtgattctg 3270121 attgtggcag ccggcgatgc caagatcgac aacaaaaagt ccaggcaaac atttggcttt 3270181 aaagcaagaa tgctctctcc taatgaggtg ctggagcaga caggccatga aattggagga 3270241 gtttgcccat ttggattggc tcatgatcct gaggtttatc ttgatgtatc gctgaaacgg 3270301 tttcagactg ttttccccgc atgcggcagc agaaactccg ctattgaatt aacaccgaaa 3270361 gaattatccg aattttcttt ctcaaaagtg tggattgatg tttgtaaaga ctgggaataa 3270421 aaaaacatcc agacatcgtc tggatgttta cttatttcac aaacccaagc agcatttcac 3270481 ggatgatttt gctggctgtg tttgccgttt gctctgagtg gtcgtatacc ggcgcgactt 3270541 ccactaaatc agcgcccttt acgtttacct ctgaacgcgc aatttcatgg accgatgcaa 3270601 gcagttcttt agacgtgatg ccgccggcgt caaccgttcc tgtacccggt gcgtgtgcag 3270661 ggtctaatac gtcaatgtca attgtgacat aaaccggacg gcccgccagc ttcggaagca 3270721 cctctttcag cggttcaagc acttcaaatt ttgagatgtg catgccgttt tccttcgccc 3270781 attcaaactc ttctttcatg ccggaacgga ttccgaatga atacacattg tgcggtccga 3270841 tcaattctgc cgccttacgg atcggcgtgg agtgagaaag cggttctccc tcataatcaa 3270901 cacgaagatc tgtatgtgcg tcaaaatgga taatcgcaag gtctgggtat ttcttgtaca 3270961 tcgctttaat gacaggccat gacacgaggt gctccccgcc catacccatt gggaacttcc 3271021 ctttttctaa aatgctgtcc acgtactctt caatcatatc caggcttcgc tgcggatttc 3271081 cgaacggcag cggaatgtcg ccagcgtcaa agaagttcaa gtcagccaga tcgcggtcta 3271141 aatatgggct gtattcctca aggccgattg acacctcacg gattctgctt ggaccaaagc 3271201 gtgagcccgg gcgatagctg actgtccagt ccatcggcat gccgtaaaga atggcgtccg 3271261 cctcttccca ctcgggacgg ctcgcgataa atacttttcc tgaataagct tcatcaaatc 3271321 tcatctataa taccctcgct ttcctgtaaa aaagcgcaag attcgctcct gcgccatacc 3271381 ttcattattt aatcaggtca ctcacaaatt tcggcagaac aaacgccgct ttatgaatat 3271441 cttttgtgta atatttcgtc tcaatatcga agaaacggct gtcttccact gcaagcggat 3271501 catatttttt cgagccaatt gtaaatgtcc acaaaccgct tggatatgtc ggaatgttcg 3271561 ccgtatacag cttcgtaatc gggaagattt ccttcacgtc gcgctgtaca tttgtgatta 3271621 attccggtgt aaaccatggg ttgtccgtct gcgcaacgaa aataccgtct tctttcagcg 3271681 cttttgcgat tcctgcgtag aatccttttg taaacaggtt tacagccggt ccgactggtt 3271741 cagtcgaatc taccatgatg acgtcatatt gattttcaga ttttgcaatg tgcataaatc 3271801 cgtcatctac ctgcacgtca acgcgcggat catccagttt gcctgcgata gaaggaagga 3271861 actttttaga gtattcgata accttgccgt caatatctac aagtgtcgct tttttcacgc 3271921 ttgggtgctt caggatttct ctgataacgc cgccgtcacc gccgccgact acgagaacgt 3271981 gctccggatt tgggtgcgtg aataatggga catgcgccac catttcgtga taaacgaatt 3272041 cgtctttttc agatgtcatc accatgccgt ccaaaaaaag catgttgccg aactcttctg 3272101 tttccaccat ttctaaatgc tgaaactccg tttgttctgt atgtaacgtc ttgttaacct 3272161 tcatcgtaat gccaaagttt ttcgtctgct tctctgtgta ccaaagttcg ctcaattgtc 3272221 atctcccttt cgaggctgta ttcatttatt gtaagcgtct tatcagcttt tattctcggt 3272281 tgaaatctca ttttcaccta aggaaaaagt atagaggatg gcggggaaaa agtaaagatg 3272341 cgtcctgttc tgcgatgttt aaaaacgatc tttttttctc ataatagtag aaacataaaa 3272401 aaagggggaa cccgttgtgg atgcaatgac aaataaacgg ctgagactga cgctgaaaac 3272461 cgttcgcgcc tttatctttt taggggcttt tgcggccttg gcggcagctg ctgtgtttat 3272521 gactgtcatt ttgatagcca aataccaggg cgctccctcg gtgcaagtgc cgcaatccac 3272581 gattttgtac gcgagtgacg gctcaaagct cggggaaacg aactacggcg aaaagcgcta 3272641 ttgggtcccc ttaaaggaca tgaatccgac gatcgtaaaa gcgacagtgg cgattgaaga 3272701 ccagaatttc tacgatcatc acggctttga ttataaacgc atggccggcg cggcgcttgc 3272761 tgacctgaaa gcatttgcca aggttcaggg tgcaagcacc atcacccagc aatatgcgag 3272821 aaacttatac cttgaacacg acaaaacgtg gaaacggaaa tggaatgagg cgttctacac 3272881 gatccgtctg gaacaaaact attctaagga cgagatatta gaaggctatt taaatacgat 3272941 ttactacggc cacggcgcct acggcattga agcagcttcc cgcctgtatt tcggcaagca 3273001 tgccaaaaac ctgacggatg cggaggcggc gcttttggca ggaatcccga aaggcccttc 3273061 cggctattca ccgtatgtca atgagacgaa ggccaaggaa cgccagaaaa cgattgtgcg 3273121 gatgatggaa aagcagcaga tgatcagcca aaagaaagcg gatgaattga tcaaggaacc 3273181 tctttcctat cagcctttga ataaacaagt ttccaagaga aaggctcctt atttctacga 3273241 caatgcgatg agagagctgg aaaaaaagct cggcatgaca cgggagcaaa ttgaaacgag 3273301 cgggttaaac gtctatacaa cggtagataa acggatgcag cgcatcgccg aggagaccat 3273361 taccgaaacg gttaacgcgg gctctgacat tcaagtcggg ttttcagcca ttgatccccg 3273421 caccggaaac gttctcgccc ttgtcggcgg cagggattat caaaaaagcc cgtttgaccg 3273481 gacgacacag gcgaagcgcc agcctgcttc gacgatcaag ccgttgctgt actataaagc 3273541 gattcagagc ggatttacgc cagtcacttt gatgaaaagc gaagaaaccg agtttcaaat 3273601 tgatgcaaag ggagaaacct attctccaag caactataac ggatactatg ccaacaagcc 3273661 gattacgctt ctgcaggcgc tggcgctttc cgacaatatt tacgctgtga aaacgcatct 3273721 ttttctcggc acgaacaaac ttgtaaagac ggcaaaggaa ttcggcatta ccgcccatct 3273781 tcaagcactg ccgtccctgg cactcggcac cgaacccgta cgtccgattg agatggtcaa 3273841 cgcctatgcc atgctcgcaa atggcggaaa gaaaatcgaa ccgactttta tttcaagagt 3273901 aacggacgca gccggccacg tgctgtacga aaacccgaat cagcataaac aggtgcttga 3273961 tgaaaaagcc gcttttgtca cagcgagtat gatgacaggc atgtttgata tcgatttaaa 3274021 tggatatacg tcggttacgg ggcgaacgat agccaaccgc ctgacaagaa cgtatgccgg 3274081 aaaatcagga accaccagcg cagacagctg gatgatcggc ttcaatccga agctggccgc 3274141 cggtgtttgg accggctatg acaaaaacag caccatcgac tcggtcgaag aaaaaagcta 3274201 tgctaaaacc atttgggcgg acttcatgga ggacgcgctc aaaggcgaac cggaaaccgc 3274261 gttcaagccg ccaaaaggcg taaccggtgt gtacattgat ccggaaacag gctactcatc 3274321 aggtcccggc tgcgccgcta agcattacac atattttgtg aaagggacag aacccgcaaa 3274381 cgtgtgctac ggggcagaac ccgcaaaaca aacaaaagac cggcttccat ccaaagaaaa 3274441 gcccgcttcc gagaaaaagt ggtgggacaa atggctgggg cgacatcatt gaaaataacc 3274501 cggctcctcg gaggccgggt tattcgtatg gttccttcat aatcgatgga agaatgttag 3274561 acaatcgagc tgaacaatca gttttgggat aaagtggtga atttctcatt tcttcggcgc 3274621 tggctttcat ctcccagtcg ccgactcata tccccctaaa aatgaaaaac cccgagtctt 3274681 gtttcggctc gggattttcc atgtcctatt tctgtatcac cagtttactc aatgtttacg 3274741 aaaaatatct caaatacttt aaaagttcac aaaaaattca taaattaatt gttttctgga 3274801 agcaggctcg tttttaactc atctgaggaa cggtcccata ggccctgatc atgctttttc 3274861 agaaattcgc ctagtacacg cttcgagctg tcgtccattt tatcaacgat gattttccgt 3274921 ttcatggatt tatccatcag attcacatgc tcaggcagtg acttgtagcc tcttctgatg 3274981 cttctgtcga ccgtcatttc acaggctgtc acaccagcgt aataaggccc ctcttctttt 3275041 ctgtcaatcg ttacccacac aagccagtat ggttttccgt tcggcacttc ttctttattc 3275101 gggagaaatt taattccttt ttcaacggtg ctgcgggcat gcatagcgcc gatgtctacg 3275161 aacgcttctt tttcctctac atcaacgaat acgggagaaa tgttatcaag gctgagtgcc 3275221 cctacgccaa aaccgccgtg tccgtctgtc ggatcacttt tgataatatt aaacccgatt 3275281 gattttttct ttttttcttc catgaagttc tacctcctac aaaagcggtt gaaatatcgc 3275341 tgaaaacagc tttaaaatcg aatctcttcc tgcattgagc atcggccaca gcacgtaaga 3275401 tcctagcggt gtcacaaaca gcaccaaaaa tacgataaag ccgtagctct ccgcctgcgt 3275461 cattttggca cgcacgcccg gcggaacgag atcttctata attcgatagc catcgagcgg 3275521 aggaagcggc agcagattaa ataaaaacaa gacaagattc agctgtatcc aaatagaaaa 3275581 aaactgatcc agccccgtgc tgaacgccgc aagcatttcc attccgtacg catgcatcaa 3275641 cactaacaaa aagaaaccaa taaacgcaag aatcaggtta ctgacgggcc cggctataga 3275701 tacgagcaca ccagcaagcc ggggtttctt aaagaaacgg cgattcacgg gaatggggcg 3275761 cgcccacccg aatccggcca ccagaatcaa aatggttccg aacggatcaa ggtgtttaat 3275821 gggattcagc gtcagtcttc cttgtttttt cgccgtatcg tcaccgaatt tgtatgcgac 3275881 ataagcgtgg gcaagctcgt gcatcgtaaa cgacacaatt agcgtgatga cgaggtatgg 3275941 cattaaagat aacggataat ataaaaaacg gtccaagtga gatatccctc tttctcaaaa 3276001 tgcaagaatt tactttattc agtatactat aagaagcctc tttttctaaa gagaggaaac 3276061 gagataaagg aggattcagc acccatgcca tacgtaactg tcaaaatgct cgaaggccgt 3276121 acagacgagc aaaaacgcaa tcttgtcgag aaagtaacag aagccgtaaa ggaaacaacc 3276181 ggtgcttctg aagaaaaaat tgttgtcttt atagaagaaa tgagaaaaga ccattatgcc 3276241 gtcgcaggca aacgcctgag cgatatggaa taatctctat aaagccggcg cttcgcgcac 3276301 cggcttttat tatccctatt gagccagctt cgcaataatc gccaagaacg tctttttctc 3276361 ttcggctgtt aaacgttcaa acatgccatc aatcagctgc tggcggtttt cgatcatttg 3276421 ttcagccgct ccccggcccg attcagaaag agtaatccat acagtgcggc ggtcattgtt 3276481 atttctggat ctctcaataa acccttcctg ctctaaatga ttcagagctg tggtcgtggc 3276541 agagggagac agtgtgacct ccttcaaaat atcctttatg gtgcagctcc catgtctgta 3276601 tatgatccgc agaataaacc ctcttacatt attcacgtgt ttcggaacgg tggcttcatc 3276661 taattgcttc gtgcttttca aatactttgt aagtgcgtga tccagcaaat ttgcttccag 3276721 tttgtcatgg tccatgtcaa tttccccatt tcgagatgca ttcataacat acgaacgata 3276781 tgatttactt attattttac tgattccgaa tagggaaagt caaaaaagca aaatgtgaat 3276841 tcacagcttt tatcctacat gcctcgattt tccacctgtt tcacaagttt atctttaaaa 3276901 gtttggaaag gaacgtgttc attctgctga tgtccgaatc ggcggacgtt taccgcattc 3276961 tcctgctcct catgatctcc aagcaccagc acgtacggaa ttttttgcac ctgcgattct 3277021 ctgattttat agccgagctt ctcattgcgc tcatcaatgc cggctcttat ccccgcctgc 3277081 ttcagctccg cctgcacttt tctgcaatag tctaagtgaa cgtgcgaaac cggtatgatt 3277141 tgaacctgga tcggtgcgag ccagactgga aaagccccac cgtaatgctc gatcaaaatg 3277201 ccgaagaaac ggtcgattga gccgaaaacc gctctgtgga tgacaacggg acgaaccttc 3277261 tcattgagtt cgttgatata tgttaaatca aatttttccg gcatttgaaa atcaagctga 3277321 attgtcgcgc attggtggct ccgtttcagg gcatctttta tatggaaatc aattttcggc 3277381 ccgtaaaacg ccccatcgcc ttcattgatc tcataagaga ggccaagctc ctcaaggacg 3277441 cgtgctaagg cacgttccga cgcttcccaa aggctgtcat cgcctaatga atcctccggg 3277501 cgagtcgaaa gctcaacaga atactcgaaa ccaaatgtcc gatatacctc atcaatcagc 3277561 cgaatcgctt ctttgatctc actctcaatc tgatcctccc gaacgaaaat atgggcgtca 3277621 tcctgacaga acgtccgaac gcgaagcatt ccgtttaaag cgccgctgta ttcatggcgg 3277681 tgcacctgtc cgaattccgc catgcgaatc ggcagatccc gataagaata caggctgttt 3277741 ttaaagatga gcatgtggcc ggggcaattc atcggcttca ttgcgaatct tgtatcatcc 3277801 acttctgaaa agtacatatt gtcgcgataa tggtcccaat ggcctgactg ctcccataac 3277861 cgctgattca tcataaacgg cgtacgcacc tcatcgtagc cggcatttgt ttgcagctca 3277921 cgcgagaagc gctccagctc attgcggaca atctgccctt tcggcaaata aaacggcatc 3277981 cccggcgctt cttcagaaaa cataaacagc cctaactgtt tgccgagctt gcgatggtct 3278041 cgttttgccg cttcttctag catatgcagg tgcgcatcca aatctttttt cttttgaaac 3278101 gcaaccccgt acacccgctg caggacttca tttttgctgt ctccgcgcca ataagcgcct 3278161 gatactcttg tcagtttgaa cgccttgatc atccctgtag aaggaagatg cggccctcgg 3278221 cacaggtcaa cgaattcccc ttgctggtac agtgtgatat cctccccgcg cggaatatcc 3278281 tttaaaatct caagcttgag ccgctcgtct ttttgtgcaa acagctcttc agcttcttcg 3278341 taagaaacct ctatacgttt gatttcaagg ttctcattta ttatgttttt catttctttt 3278401 tcgatggcct ctaagtctcc tgatgccaag cttttcccca gcttcatgtc atagtagaag 3278461 ccgtctaaaa tcacaggccc tacccccaat gacacttcgc cgtacagccg ttttactgct 3278521 tgggccagca cgtgcgctgt tgtgtggcga agcacctgca agccttcttg tgaatcgagt 3278581 gtgacaatcg aaagctcagc atcctcctcc agcttgaaac tgagatcaac aagcttgccg 3278641 ttgacctgac ctgcggccgc cttcttttgc agactggaac tgatcgaacc agccgcttct 3278701 ttgattgtga tgcctttcgg atattcctgg atctgtccgt ccggaagctg aatgtgtaca 3278761 tgtttgctca ttttagaaca ctccttattc attgttgtat ataaaaaaac acacccgtcc 3278821 cgcagatagg gacgagtgtg tgattaaccc gtggttccac ccaagttccc gacaaatact 3278881 atgttgtcgg ctcggtgctg taacgcagca tagacggcat tggttacttc agttccccaa 3278941 tgctgctcca aggcggtaaa tgatattcct aagctgggaa gctctcacct ttccttccct 3279001 ctctgaaaac cgtaactatc attcatgtcc ttttcatcgc atgtattcaa ttcataaaaa 3279061 aacacacccg tcccacagat agggacgagt gtgtgattaa cccgtggttc cacccaagtt 3279121 cccgacaaat actatgttgt cggctcggtg ctgtaacgca gcatagacgg cattggttac 3279181 ttcagttccc caatgctgct ccaaggcggt aaatgatatt cctaagctgg gaagctctca 3279241 cctttccttc cctctctgaa aaccgtaact atcattcatg tccttttctt cgcatgtatt 3279301 caattcaaat aaaaaaacac acccatccct ctaaaaggga cgaatgtgtt gatcatccgt 3279361 ggttccaccc aaattcccga tcaattacac atgatgatcg gcttaaagat gctgtaacgc 3279421 agcatgacgg tatcagatac ttgttttccc tgatacggct caaaggcggt aagctgcttt 3279481 ccctgcgtta ggaagatctc agctgtcctt ccctctctgg aaaccgtaaa aagcatctcg 3279541 tgtccttatc agtgcctgtt gtttcaataa ttttttatat cttactatat attcccacaa 3279601 agcgcaatca gtgatttaca ttttttctga cgcggcagtc ccgttatggg cagccagaaa 3279661 cagccataca agcaatgcag cgaggctgta tgccgctccc atcatcaaaa acgcaaaccc 3279721 ggcaccagca taccaagtgg cggacagatg aatgatcacc ccggttatcg ctacgccgac 3279781 caaggctccg atttgccggt ttgcatttaa cgccgcaccg gcgatattcg tatgtctttg 3279841 cccggcagcc tgcatgatca cagttgtcat ggcaggaact gtaataccgg tacagaggtt 3279901 cataacagac atcaacaccg ccagctgcca ataaggaaaa tccggagaaa tcagcacaaa 3279961 caacagcaat gcaatgatac agctgaccgc cattgataca aacataagct gaccggcttc 3280021 aaaccgattc gccagacggg caaacagcag attgccgatc acgaagaccg ccatcatcgg 3280081 cagcagctcc actccagcca taaaggaact tgcccctcct gcttcctgca aaaaaaggct 3280141 gagcataaac atgccgccaa aaagggcgaa attcagcaaa aacccgataa attgggcagc 3280201 tgagaagcgg ccgtttttgt ataaggacgc cggcaggatg ggtgtttttg cagaaatttc 3280261 ccgcagcaaa aacagcacaa atgccaaaac cgctgcagta aatgctacaa gaatcactgg 3280321 cgagcgccag cccgctgaag gcccctgtat caaagcatag gaaagaaacc cgagagccat 3280381 catgccaagc agatgcccga tgatgttcac gcggctgctt ttcccaggaa cgcggctgag 3280441 gattcggtaa gctgaaatga gcgcagcagc ccctattggc acattgatca gaaaaatact 3280501 ctgccagccc gccaactgta ccagcacgcc cccgataaaa ggcccaaggg ctgaagcggc 3280561 ggaaacaagc gcggcccaca gtccaaacat tctcgcccgc gcccgctcat caaggtaaga 3280621 ggcagccaaa aggctgagtg agcttggcat aaacaaagct gccccaattc cctgtatgag 3280681 acgtccggca atcagcatct gcccatttat agatgcagcg catagacagg aggccataac 3280741 aaaaacggct agacccaaga tatagatcgt cttcgagccg aaacggtcag ccaaggctcc 3280801 gcccgccagc agaagcgacg caaaagtaag aatgtacccg tccacaaccc acgttacacc 3280861 tgaaagtgac attgaaagag tgtttttcat atcagccatc gccacattca caacggtcac 3280921 atcaagagtt gccatgagga aaccaagtgc gagcacgatc agcacggata tgcctgttga 3280981 tgatgttgat tcttgtatag acccgctatt tttcattaca attgcccttt cacttgcttg 3281041 attacccaat catctatttt ttcaagatca tacaattccc cgactctgtc cataacatgc 3281101 tgcaaggatt cttctctcat aagattggac catttatcct cgatttccgc catgactgtc 3281161 tccagcacac agtgactttc accctcaaat acagattgca gcaagccttt cccctgatac 3281221 atcgaacctc tgccttcgac cgcttgataa acatcataaa gcgtaatgtc agccaaaggc 3281281 ttcgtcaggg taaaaccgcc cttcgtccct ggtaaggatt ctgccaaacc ggcttgaacc 3281341 aatgttctca tcagcttctt caagtaagac ggagacacgc gcaatcgctg gcttatagcc 3281401 tctgacgtca aagaagcctg taccggcagc cgtgacagta acagcagcac agaaaccgcc 3281461 tgctccattc ctgatttcat tttcatccta ttcactcctg attcattatg gataactatt 3281521 atccataatg aatctcttag cagcttttgt caataaaaaa agcaaaagaa acggatcatt 3281581 tcttttgctt ggtatggtta acaaatctgc ttcagttcct ctatgtattg aagcgcttcg 3281641 tcatattctt catttgtata tttttgcttg cttttgatgg taaagacttt ttctttcttt 3281701 tcctcatcct caagcccgtc aaagtaaagg atcgtggaaa ccagctctaa aaaccgtgat 3281761 gaacggctgt ttacactgtc gatatagcct ttcatatccg gcatgtccag atcagcatgg 3281821 tctaaaaatg cggagcctgt ctcagtcagc gaataccggt attgaaagta gccgcccttt 3281881 ttttccttca cctcatgcag aaatccaagg ttgcacagct cttcaatctg gagcgtcagt 3281941 tcctctgaat atggtccgta aaagtgaaaa tcatatttct catagaaagg aaactgcatt 3282001 ttcttggcga tataaatcat tttctgcagc ttctttcgcc cgatgatttc tccagaatcc 3282061 gagaacacct tcatcagttt tgcatgttct ttcaacaaat tcccgacatc tcctttttcc 3282121 ttctttccaa tttctatgtc agtcccagca gctgccggat tttcattttc gcttccggat 3282181 gtttagtgcc gtcacaaatc aagtcctttg gatagtacag cttgtggtcc gtccgccgtt 3282241 tacctgagat ggattccaca atagccgact gtctggacag ctctttaatt tggccgtttt 3282301 gcgtcaagag atggatcggc agacgctcct cttcctctcc tggtcggtaa aaatcgtatg 3282361 gcagatctga tgaagaatca acgaccaaat aatagctcgg atcgatcccc gcctctttga 3282421 acaatgaagt cagctcaaaa taagccgaca tttcttcatt cggattgaat tcaacgtatt 3282481 ggaaaagctg gcggttaatg aatctgcggc acaagtcgga taaaatcgcg tcttcttcat 3282541 cctcccaggc ctggaagtaa tacaaaataa tagattcatc cagctttaca taatcctcca 3282601 gtgtcaattt tccttcaaaa atagaataga aatgaaccgg agcgtgagtg aagacatagc 3282661 cttcatcgtg cagctgcttc gccctgtgaa gaatcttcgt taaaatgacc tctgcacttc 3282721 tagtcacagg atggaagtag acctgccagt acatttggta acggctcatg atatagtctt 3282781 cgacagcgtg cattccgctt tctttaatga cgatctgatc ctcgcgcggc cgcatcaccc 3282841 gaagaatccg ctccatatca aaatggccgt agctgacgcc cgtataatat gcgtcgcgct 3282901 ggaggtaatc catgcggtct gcgtcaatct gactcgaaat caggctgacc acttgcttgt 3282961 ttttatatgt tttggcaatg acttcagcaa catcctgagg gaaacccggg ctcacctttc 3283021 tgagcacctg attaacctcc gtgtctccca aaatgatacc tcttgtaaaa tcctcgtggt 3283081 caaggtgaaa gaccttttca aatgaatgcg agaacggccc gtgcccgagg tcatgaagca 3283141 gcgccgcggc caaacagagt tcgcgctcac tgtcatccca ttcagggcgg cctttaaaga 3283201 cgtcatcaac cattcttctg acaatttcat agacaccgag agaatggttg aaccggctgt 3283261 gctcagcccc atggaacgtc aaataggtcg ttccgagctg cttaattctg cggagacgct 3283321 gaaattcacg ggttccgatc aaatcccata tcagcttgtc ccgaacatga acatagcggt 3283381 gcaccggatc tttaaacact ttttcttctg ataattttcc atttggatac gccatcgtca 3283441 ttccctcttt tttttagccg tgtttctatt atatcgactc tattctttga aaacatcctt 3283501 gaatttgccc ggcgatttgt tccatcttca tgaaaaacac atcttgtgaa gcaaaaaagc 3283561 ctgacctgag ggccgaggct aagaaaaaat atgtttttac ttttttattt tcttttttac 3283621 tttgtcaatc agctcatcct ctgtcggagc tgacagcggg cgattgttca caaaagcaaa 3283681 tgattttttc cgtccgggcc cgcaataaga ttggcatcct acctcaacct ttgcgtccgg 3283741 gtccacttct ttcaaacgcg gcagcaatgt tttgatatta gtggcttggc aatcatcaca 3283801 cactcgaaat tcattagcca tgacgtacgc ttcccttcat ttctatgttc atctatgtga 3283861 ataacctaaa atcacgtttc aaaaaaaatc acatcacact tcattttaca aggattcgac 3283921 tgttcctgca agccgctcca tccttcgtat ctcctattct ttcagccaat ttgtataaat 3283981 attttccaac ctggacattc taataccatg aaaagaaaaa tgggagttga gataaatgac 3284041 aaaacagcga caagacgctt ggtcagagga aaacgatctg cttttagccg aaacagtgct 3284101 tcggcatgtg agggagggca gcactcagct gaacgccttt gaagaagtcg gcgataaatt 3284161 aaaccggaca tccgcagcct gcggattcag atggaacgca gtggtccgcc atcaatatga 3284221 aaaagcgctt cagcttgcga agaaacaacg aaaacagcgg atgagagcgc tcggaaacgg 3284281 gcagcccgcg aaaaaaagat tattatatca gcctcctgcc gttgatcctg aaatcattca 3284341 agaaaccgct gcagaagagc cggttaaaac ggaaacacca tctgtcgaaa atgagcaacc 3284401 tttaatgtct ggcgaacaca tgccttttgt tgatgaaagc tttaaggaag agttagctag 3284461 tctatcacac ttattgtctc ctcaaacgcc tgcagctgcg cctgagatga cgatgaatga 3284521 tgtgatccgc ttcctgcaga attacgaagg caatcacgag caatcatcag cattaaaaat 3284581 ggaaaacgag cgtttaaaga aagaaaatca ggaattgcaa aacaaaacag agcagctaga 3284641 ggcagaagtt caaaagcttg aaaaagacca aaaaacgatc caagaagatt atgaaacctt 3284701 ggtgaaaatt atgaacagag ccagaaagct agttttattt gaagaagatg aacatgcctc 3284761 tccgtccttc aaaatggacc ggaacggcaa tttagaaaaa ttagcggaat gacatagaaa 3284821 aatcccaaaa cgggcagctg ttttgggatt ttcgccatgt gcaaaatccc cttttctatt 3284881 gagaaaagag aatttcctca ttttgcagcc ggatcagcta ttcttgtaaa atgaggccaa 3284941 gcttatgtga atctattaag acatgtgagc tgcctcggcc gttttttgtt tccgaggcgc 3285001 agcagaaatg accaaaagcc ccagcatcat aagcgcaatg cccagccacg aggaaggcga 3285061 aagcatttcc cctatgaaaa acacgccaag caatgaagcc gtcagcggtt cagctaaaga 3285121 cagcgtgacc gccgccgagg ccggaacccc ggtaagccct ttcgcaaaca aaaagtatgc 3285181 ggcacatgtt gcaattaacc cgatgtaaag gcttgttccc agtcctctag gggtcaatat 3285241 ccacgagata tctaactgcc ataatagcgg cgtcagcaag atggcgctga tcatgaatac 3285301 aacggcggag gtcgctcgcg gaggctgggt tttcatcatc gctttactga tgagcgtata 3285361 gcctgcaaaa gaagcacccg ctccaagcgc cataagaaca ccagccacat caatccgaac 3285421 attggaactg tcggaaaaca gaagccagca acccgctaaa gccagcacag tcgcaatcca 3285481 ccaggagttt cgcgggcgtt tcttcaatac agcccattcg agggtcccgg caatgatagg 3285541 cgcactgccg atggcaatca cagttcccac tgcaattccc gtttctttaa ccgctgtgaa 3285601 aaacagcggc tggtaacacg ccatacaaac agcggctaaa aatacgagcg gccatgccca 3285661 atttttcacg tgaagctccc ggctgatcca aaccgcaagc agcatggcgc ttcctcctat 3285721 taataacctg aacgctccaa atgccagcgg tgtggcgctt tctggagcca atgcctgaac 3285781 ggttcccgtg gtcccccaga aaaaagccgc aatcaataca aaaaggctgt aaatattccc 3285841 cttcatctgc ctctcccctt taatatggat gctgatgtca ttttatcgtt tttctttttg 3285901 tcgtggttat ctgtatgtaa gaaggactta tctgaaaata agattattga ggtaaaatgc 3285961 cgcttgagat aaaaaatgca tgccggcata tacagccggc atgcgaagaa cgttcaccca 3286021 aatacctttg cattccgctc agccatccgg acgaggtttt tctcaaattc catttcctca 3286081 tcaatggaca gtccagctga ataaagatgg gtgcttaacg cttttaattc cgtcaataaa 3286141 gcgaacatta agtcttgtac ggagatgtct ttttgaagaa gctcacttaa ggacgccatc 3286201 gtttccggac gtatttccgg atagacgcct tttttatcgt tttgtttgtc tttcagcgcc 3286261 gcttgataga atcgtctgat caagtcggcc ctttcactgc cgcttttatc tgcacagaga 3286321 taaatttgaa cagcgactcc gccgcgaacg cgtctctgag agatgccggc gaactttttg 3286381 ccatttatac tgaggtcata gctgccggga caataagacc cttcaatttc ataggcttcg 3286441 atctttgcgt tgtacggtct cagcattcgt ctcatcagct cgaccatcgc ttcatatcct 3286501 ttgtctatat cgatgccttt cttttcgtcc tcgaatatga gagagatatt taaaacaccg 3286561 tcatccaata cgacggcaag accgccggaa ttgcgtacga tcacacggta tccttcgctc 3286621 tccagcaagg agataccatc ctgcaaaaac gggaggcgtg tatcctgtat tccaaggaca 3286681 attgtatcgt ggtgcaccca tgagcgcgct gtcgccggcg acacgccttt tccgacggac 3286741 atgcatagcg tatcatccat tgcgaaggat tgcttcgcat caaataaagg gccgagactg 3286801 gattggtcaa tgactctcca tttcggctgc atcagtaaat caatcggttg gtttgccatc 3286861 tatgtaaaac cctttcatgt taggcttatt gaacgaaaac tattatatca tttcagcagc 3286921 tgtgattgat aattgctttt cagcatcgta ataaaaattt ctttattttt tgtattctcc 3286981 atgagaggag aatgaatgta agacagcttg cgctttaacg agaaattatt aatatgcaga 3287041 attgaaattt cgcggtggat caaatcctta cgcagcacgc ttctggatag aaccgaaagt 3287101 cccatgccgt taatcaccgc ttcctttaca ccttgattgc tgctgatggt aaacattgat 3287161 ttcggccgaa gtccatttga actgagtaca tgatcgagat attctctcgt cccggagcct 3287221 ttctctcttg tcacccacgc ttcgttctgc aaatcgctga tcgaaatctc tttccgcccg 3287281 gcgagcggat gctgatttgg agcggcaatg cacatttcat cctccatgaa cggttcaatt 3287341 tccagctcat tctcgtttgt atgtccttca atcagcccga tatcagcctg aagcatccgc 3287401 acacgctcgc tgacctcctc tgtattgcca atcatgacat ctagattcag ctctggatac 3287461 agcttttgca gctgggccaa tagcggcgga agaatatact caccgattgt aaagcttgca 3287521 gctattttca attcaccctt cacatagtga tgatgcgcat agatttcagc cttggcttgt 3287581 tcgtagagaa acaccatttg ctttgctctt tgatataaaa tgtctcctgt cggcgttgtc 3287641 gtaaagtgtt ttggcgacct gttcagaaga gccgtttgaa attctttctc aagatttttg 3287701 atatgcagac tgacgctggg ctgggagatc atcagctttt ccgccgcttt tgtgaagttt 3287761 ttttcttcta ccaccgctat aaacgttttc agcacgtcgt aatacaaaaa ccccacccct 3287821 gtcattaatg aaatatatgg ttatgattag ttttctttat tgtactcata tcatccgtct 3287881 tggtaaagaa gggctataca gaagcgcaaa aaaggcagcc ctcggtcgag agctgccatt 3287941 gtcttcaatt ttattacagt gcttgcgccg ctgtaattaa tgcgagattg taaacatctt 3288001 cagcgttaca tcctcttgaa aggtcgttta caggcatatt taaaccttgc aggattggtc 3288061 ctaccgcttc aaagttgccc aaacgctgag cgattttata gccgatgttt cctgcttcaa 3288121 gacttgggaa tacgaatacg ttagcgtccc ctttgatctc ggaatccggc gcttttttct 3288181 cagctacaga tggaacaaat gcagcatcaa attggaattc gccgtcaagt gtcagttcag 3288241 gcgctttttc tttcgcgatt ttcactgcat ccgctacttt ttctgtttca tcagattttg 3288301 ctgagccttt tgtagagaag ctgagcattg ccacgcgagg ctcaatgtcg aacatttttg 3288361 ccgtattggc actttcgatc gcaatctcgg caagatcttg gctgtcaggt gcaatgttga 3288421 tcgcgcaatc tgcgaatacg tattgctctt ctccgcgagc catgatgaac acgcctgaag 3288481 tctttttcac gccttctttt gttttgatga tttgaagagc cgggcggaca gtgtcagcag 3288541 ttgagtgagc agctccgctt acaagtccgt ctgcaagtcc tttatacacc agcattgtac 3288601 cgaagtagtt ctcgtctaat aatgctttac gagcctgttc ttcagtcgct ttgcctttgc 3288661 ggcgttctac gaatgcttgt acaaggtctt ccatgccttc atatgtatga ggatcataaa 3288721 tcttaacgcc gcccagcgta aggttcaatt cttttgcttt tgcttggatc tcattttcat 3288781 tgccgatcac aatcggattc agcactttgt ttcctgcaag cttgctgacc gcttctaaaa 3288841 tacgctcgtc taagccttca ggaaatacaa ttttaacgtc ttttccagct actttttctt 3288901 gcactgttga aaataaatct gccacaataa aacctcctca aaaagttaca aaaacgcttt 3288961 cttttactag catactcttc ttccaatcaa attcaaacag ccaactttca ttatagcgct 3289021 ttcataaaaa aatcttattt ttctaactaa tttaagtgac tcaatcttcc cttataggtt 3289081 cttctatttt gatggagtta tacggaaggg atgttcaagg tttctccaca gtagaatcgg 3289141 ataaactatg gtatagtgaa ggcaatcatg aaaagataat gggagtgaag ataaatgagt 3289201 gaacagcaaa tgacgaatga agcggcaaaa acgcttgacg gctggtatgc gcttcatgat 3289261 ttccgcacaa tggattgggc ttcctggaag cttctgtcca gtgatgagcg ccaatctatc 3289321 atacatgaat tcaccgggtt gcttgaaaaa tggggcgtag cccaaaaaga aggaaaagga 3289381 tcgcaaactc tttacagcat cgtcggccaa aaagctgatt ttatgctgat gatccttcgt 3289441 cctacaatgg aagaattaaa tcaaattgag cttgaattca acaaatcaag acttgctgag 3289501 ttcaccattc cggcatactc ctacgtatca gtggtagagc tgagcaacta cttggcaagc 3289561 ggtgacggcg atccttatga aaatccgcat gtgcgcgctc gcctttaccc tgaactgccg 3289621 gaatctaaat atgtatgctt ctatccaatg gataaaagaa gatctggcaa cgacaactgg 3289681 tatatgcttt caatggaaga acgcagaaac ttgatgagaa gccacggttt aatcggccgc 3289741 agctatgcgg gcaaagtcaa acagatcatc accggctctg tcggctttga cgattacgag 3289801 tggggcgtta cattatttag cgatgatgtc cttcaattca agaagctagt gtacgaaatg 3289861 cgttttgacg aagtcagcgc tcgctatggc gaatttggtt cattctttgt cggcaatcac 3289921 ctttcgcttg atacacttcc tcaattctta tatgtataat atccccgagc tcgtttattg 3289981 agataaggac tgatcggcct tctgctcaag tttgccgtac tttttatatg cgaatacact 3290041 gagcacaaat ccgaggactg tgatggcggc gcaaatcaat ccgacagctg catagccgta 3290101 tgccacatat acgggtccca ttaaagcaga acctaatgtc acggccagat tcgaggcgag 3290161 actgtaaaac accatgactt ttcctcgatg acgctctgag cagtcactca aaatggtgct 3290221 gagcagcgtc accgtcaaac tttgcattaa tccccaaata aataggctgg cgattaacag 3290281 aaacatagac gccggcgcat atggtaaaca cgccagcaga acgctgatga cccccagcgc 3290341 aatcaaaagg gagcgcattt ttccgatgcg gtcggctatc tttcctgtaa tcacactcat 3290401 ggaaaacccg attccataaa tcatgataaa taagcccgca gccgtgtttc ctccggtaaa 3290461 aacgtcctga agataggtgc ctaaaaagga atacataccg taaaaaccaa tcatattaca 3290521 aaaggttatt gtgatataaa caggtacacg agggactttc agcgcatccc ggaatgttcc 3290581 tgcgggctct tctatttctt ccttgccgct gtttttatgt tgggcatggc ggcgcatttc 3290641 aaggagaatc agcagaacaa ctaaaacacc catcagggcg aaaatccaaa acgtccatct 3290701 ccaatgcagg acgccgccga taaatgatcc gagcggcact ccgaaaatca gcgccagcga 3290761 ccagcttgaa acgatcagtc ccatcacctt gccccggtat gtataaggaa cacgatcacc 3290821 gacaactgcg taagcggtcg gaacaaacgc tcccgcagcc aatcccgaaa gcgcccggcc 3290881 taaaaagaag aaaaaaatat tttgagctaa agcgcatatc accgttccta tgataaaaat 3290941 cataagcccg gccaataagc tcagttctct ggagtattta tcgcctaatg gaaccaaaag 3291001 cggcgcaccg ataaaaatca taacgccgta aatactgata gataacgcaa ggacgctgac 3291061 atctgagctg aaggcttttg ctaaatccgg cagcagcggt gagatcacaa gctcttcaga 3291121 tccggctgca aataccccca tcgttaaagc cagtgccaac aataacggaa aatgatgttt 3291181 tgttttgatg tcattgtttt gattgctgtt cattctttct caaacacctc ttccataatc 3291241 ttcttatcat aaagttgtat tatagtttag cattgttttt tctctattta caattcgaac 3291301 gaaatattta taagttttat tattttcatt taaatcccat tatatatttc tatatttcat 3291361 tctaaaaata catgaggatg taacacgtaa aaaaagctct ccggcctccc ggagagcttt 3291421 ttctattgcg cctctgtctg ctttttttca atcgtttcat gatttatacg ctttttgatg 3291481 cttagatgat agtatgcata acagaaaata atgatcggca caccgcagta taagccaatt 3291541 ctttgatccg gaatgaaaat aaggctgatc aacacgcagc catataaaca aaatccgaga 3291601 atcgggacta gcggataaag cggcgttctg aactccagat cattcacatt tccgccttct 3291661 gccaggaaac gcctgcgaaa gaaaaattgc gacgcacaaa tggacatcca cgcgacaact 3291721 gtcaccatgc ccgagattga gatacaccat aaatacactg tttctgcagc catgacactt 3291781 gtcagcagcg aacagcctga aatgcctagc gtaatcagca gggcattcat cggcacgcct 3291841 ttttttgtca gtctggtgag aaaggaggga cccatttgat ttgatgaaag tgaccacatc 3291901 atacgcgacg ccgcatacaa tcccgaatta gcaacagata aaatggccgt taagatgaca 3291961 aagttcatga tatctgccga aaatgggatg ccgatttgat cgagtactgc tacaaacggg 3292021 ctttcaatca cccccgccgt tttgtacgga aggatggcaa ccaagacgaa catagcgagc 3292081 acaaagaaaa acagcgtgcg ccaaataaca tttcgaatgg actttggcag tgttttttcc 3292141 gggctttcac tttcccctgc cgcaatgccg acaagctccg ttccctggaa cgagaagttt 3292201 accatgacca gcgtaaacat aacggccagc accccattag ggaaaagccc tctatcagtc 3292261 ataaagttag acaaaaaggg tgtctcctgt ccgcctttaa agtcaatcaa gccaaacaca 3292321 gcggctccgc caatcacaat aaataatatg atcgccgcca ctttgatgct tgaaaaccaa 3292381 aattccattt ccgcaaagct tctgacagag agcgcattaa tcaaaaagat gacgatgccg 3292441 aacacgaggc accatatcca gatcggaacg gagggcagcc acctttgcat caaaatgcct 3292501 gctgacgtca gctctaaccc tactgtattg gcccagctga accaatacag ccagccaatc 3292561 ataaagcctg tcgactgtcc cagaaattta gtggcgtagg cctgaaacga tccggccacc 3292621 ggcatggcaa cagccaattc tcctaaacaa agcatgacga gatacattaa aaatccgccg 3292681 atgatatacg cggcaatggc gccgagcggt cccgcctggc taatggtaaa gccagagcct 3292741 agaaacagcc cagtgccaat cacccctccc aaagcaatca taaacaaatg cctgcttttc 3292801 atgctgcgct gcaattcatt tttatgattc tgcatcatcc ttcccccttt ggttcttttg 3292861 ccgtgatggt catccggtag ctttgcaaaa gatgaacggt ggtttgctgt atgaggagag 3292921 gcaatacatg aaatgtgtac ggtttataga ctcgttctgt ccatttatgg ccgtcttttc 3292981 cgtacacgcc catattaatg gatggaatat tcagcttgcg tatgtctttg aacggaatgg 3293041 tcccaatcat attccaccca gggaagttcc tgataaaaga atcaatttcg ccatcggttt 3293101 cgtgcagtga taaaaaactg ccgtctgcca agtaggggaa aaactttttg aagacaaatg 3293161 tttcgcctgt cgattcagcg gttttgtcag ccgcttcttt aatcacatgc tgcaaaagct 3293221 gatctcttgc gctatcttct ttcaaatagt tatgcggcag gtaaggaggt gcgtaaaata 3293281 gaatgacttt tgcgccttga tcggggtcaa gcttttgaag ctcttcgatt gcctgaaagc 3293341 atctcatgcg aagttcaagg tgctcgttgg ctttgaatgt ctgctcgata cactgctcgg 3293401 gatctattcc ccggtttctc agcttttcta agtattgctc caggctatac acttgaatgc 3293461 cccatgataa atgtttcttt ggcaggttgg ctctttttac atattcttcg taataatctg 3293521 ataatttttg ttctgtctcc cggcatgctt cctcagtgac ttcaataagc aaatccatca 3293581 tttcttttgc tgttctttca taaataaaac aattgaaata caagctggtg ctgacagccg 3293641 tttgcacatt ataggattcc ttgttatcac gctgatacaa acaggatggg ggcagaacca 3293701 actccccttc aaccttttct gccagatgga tgttattgtg gagacggctt gtgatttcag 3293761 atgaaatgaa atttgggtca atccctgcca gtgtatcgcc aacatggact tcacgcccgt 3293821 aaatgtaaaa gcaaggcaac agttttcccg cggctccggt atagatatat cttgtctgat 3293881 caccatcgta aagcggggta ataaaatccg tattaatagc agccaaatag tgaagctgtt 3293941 tttctttttt tagccggttc agctctgaaa tgctggcgag aatgcccgaa tgctggctct 3294001 cctcatcggg attggccata aacaatacat ttcccggcaa cgtctcaagg ttctccgaaa 3294061 aatgcaggag attggctaaa tgcacggcga tgccgctttg catatcgaca gatcctcttc 3294121 cgaacatcca ctcgcctgat ttggcatccc gctgaacatc ctgatcgaac tcatagcggc 3294181 tgaaatactc ggccaatttc tcacaatcaa aagcgatatc ctttaaaggg ccgaaatctt 3294241 caattccaac tgtatccaga tgggcatggt aaatgactgt atttcggctt tctccatgtc 3294301 ctttaataaa cgcaaaaata tttttgcgtt tgtatgggtc attgggaatg gcctgttccc 3294361 acacatgact ggggttttcc tgaaaataag gatagctcgt gatcacttct ttgatgaaat 3294421 ctgcttttgt cccttctcca acggtgccgt tcacgctgct gaggctgacc agagatgctg 3294481 tcagcgcctc cactctttca gccggattca tgtgactgat ttttgtatac tgcataaatt 3294541 gtcctcctga tcaaaaagtt gaaatcgtgc gatccgctaa agaatcgcac gattttattt 3294601 ctctcaaatc aaaaagcttc ggacgttgtt ttggcttgca tatgaagaat taagtaatcg 3294661 ggaccgcctg cttttgagtc tgttcctgac atattaaaac cgccgaacgg ctgatagccg 3294721 acaattgctc cggtacatcc tctgttaaaa tataggtttc cgacatggaa atcctcgcgc 3294781 gcccgttcaa tgtgcgcacg gtttttcgtc agaagcgcac ctgttaatcc gtattccgtg 3294841 ttattggcaa tctccagcat atgatcgaaa tcacgcgctt tgcaaatcgc aacaaccggg 3294901 ccgaaaattt cttcctgcat caagcgggcg ttttcatcaa catctgcaaa gatcgtcggc 3294961 tgaataaagt agccttttga atcatcgcct tctccgccgg ccaatagctt gccttcagat 3295021 ttgccgattt caatgtattt catcactttg ttgtaggatg cttcatgaat cacgggaccc 3295081 atatacgtat caggatcttc tggattgccg acagtcagcg ttttggtcag cgccacagct 3295141 ttttccacca cttcatcata cacatcctga tgaatgaccg cgcgggagcc cgcagaacac 3295201 ttctgtcctg aatatccaaa tgctgaatac acgatagagg atgcagcaag gtcaagatca 3295261 gcgtccttgt cgacaagcac tgtgtctttt ccgcccattt ctgcaattac ccgtttgagc 3295321 catttttggc ccggctgcac tttggcagct cgctcataaa tccggcagcc gactgcacgg 3295381 gaacctgtaa atgagacaaa ccgtgtcttc ggatgctcaa ctaagaaatc accgatctcc 3295441 gcaccatctc ccggaatgta attcagaacg ccgtttggca gacccgcttc ctccatgacc 3295501 tcgacaaatt ttgctgccac taccggggct gcgtcagccg gttttaagag aatcgtattt 3295561 cctgtcacaa tcgctgccac cgctgttccc gccataatcg cgagcgggaa gttaaatgga 3295621 gaaatgacga tgccgacgcc aagcgcttcg taatgatatt gattgacctc gccagcacgg 3295681 ctcttcaccg gagccccttc cttgagcttt aacatttggc gcgcgtagaa ctctaaaaag 3295741 tctatcgctt cagccgtgtc cgcatctgct tccttccacg gttttcctgc ttccttcaca 3295801 agatagcttg aaaattcatg ctttcttctg cgcaaaatag ccgctgcctt aaagagaata 3295861 tttgcgcggt gctccggtct ttgttttttc caggaatcaa atgcctgcaa tgcggcttgc 3295921 atcgcttttt cagcaagctc ttgatccgct gtagacgcgt acccaatgat ctcttcttta 3295981 tttgccgggt taatagaaat gattttgcgg tccgtttcaa ttttttctcc atttatgaca 3296041 agcggataat gcttgccgag ctgagtgttt acaaaggcca atgactcccc aaatgcagtt 3296101 ttattctttg cttccgtaaa atcggtaaat ggttcgtgcg cgtatgtgac tgtcatatgt 3296161 agtccccctc gtgttatgaa atatatcttc gcatatgaat aaaaatgcaa gaatcatgcc 3296221 attttcttgt cttttgctga aaaaacttgt tgaatcgaac agaaatttgt ctaacaggtg 3296281 atcacctttc tctttttccg atcttgaacg caaatttatt ttgcgttttt tgctctttac 3296341 gcaaaaaaca aatgcaaaat tattttgcgg aggcttctca aattagaccc atccgcggaa 3296401 acgcgatgct tctgccgatt ttctgatgcc cgtcatgtaa gccgccaaac gcatatccac 3296461 tttatgtgtt gccgctgttt gataaattgt ttcgaacgag ctgaccatga cgcttctcag 3296521 tttttctgca acctcttctt ccgaccaata atatccttgg ttgttttgca cccattcaaa 3296581 ataagaaacc gtgacgccgc cggcactcgc taggatatcc ggcacaagca gcacgcctct 3296641 ttcattcagg atcttagtgg catcaatggt tgtcgggccg ttcgccgctt caacgacgat 3296701 tgacgcctga atgttatgtg cgtttttggc tgtgatttga ttggagatcg cggcaggcac 3296761 taaaatatcg caatcctttt caagcagctc ctcatttgtg atgacgtcag taaataaatt 3296821 ggtgaccata ccaaagctgt cccgtttatc gagcaaataa gggatatcaa ggccgtctgg 3296881 gttgtagagc ccgccattgg catcagaaat cccgatcacc ttcgcgcccg catcgtgcat 3296941 gaatttggcc aggaagctac ccgcgtttcc aaagccctgt atgatgatgc gcgcgttttg 3297001 cagcttgatc ccttttttct tcaccgcctc ttcaatacaa atcgtgacgc cctgtgccgt 3297061 cgctgtttcc cgtccttgcg atcctcccaa aacaagcggt ttacctgtaa taaagcccgg 3297121 agaatcgaat tcccgcagcc ggctgtactc atccatcatc cacgccataa tctgcgaatt 3297181 ggtgtacaca tcgggagctg gaatatcctt tgtcggaccg acgatctggc tgatggcacg 3297241 gacatacccc ctgctcagcc tttccagttc tccaaatgac attgtccgcg gatcacaaat 3297301 aataccgccc ttcccgccgc cgtaaggaag attggcaatc ccgcatttga gcgtcatcca 3297361 aatggataat gcctttactt cctcttcatt aacttctgga tggaagcgaa cgcccccctt 3297421 tgtcggaccg acagcatcat tgtgctgtga ccggtagcct gtgaacactt tgacgctccc 3297481 attgtccatt ttgaccggaa tgcggacagt gagcattctc tgcggctctt tcatgagttc 3297541 atacatatct cccggataac ccagcttccg aagggcttcc ttaatgattg tttgggtaga 3297601 cagaaataag ttaagagctt ctttttcttc atctttcgag acttgctttg ctgacatctt 3297661 tttcacctca ttgttttttt ggccggctgt aatgtaagcg ctttaaaaaa tcagcccgcc 3297721 aattcctttc ttcattggat tcacccttat catcatgcaa gatccgtacc agcttttgaa 3297781 tccacaaaaa aagagactga aaacatctca gtctctgact acaaatctat cgattaacgg 3297841 ggatcaatca ccagctgcgt ttcagcataa aaactgccga ttcccaaacc gtttactaca 3297901 tcgcctttaa tcgtgtaagt gcctgcgcga ggaagagttt tacgcaccat gacaaggtca 3297961 aattcggatg cgcctaacaa atcaagcgta agcgggagtc tgactgtttt tccatcgttt 3298021 aaaatctgtg tttctttcag tgttcttcca ttcactgaat ctcttgtcgt agcatgaaac 3298081 ccgtcaggaa attgaaattc taccgctcca agagaaagca ccgcatttgg tttatatgtc 3298141 acttcaatat cagaaatggt ccactctttc gtgctgttaa ctgtttttgc ctcgattgat 3298201 gcagactgtg catgagcttg gcccgaagga agtaagattg atagtaaaac agctgaactg 3298261 atgaataatg aagatacgaa tgaagttctt tttagcatga catttccccc taattgattg 3298321 ttgaaatttg gccagagcgt cctctgcaga aaaagcgctt tttcataatt cgcgaattac 3298381 cagttctttt tcttaaaaat taatctatca tcattttcca tggaagtaaa tgttttttaa 3298441 ggaatattaa cacttggaat tcaatgagaa ttccttcctg tttatacaag gttcaaatgg 3298501 acgatttccc tctctttttc tagtaacatc tgcctgacat tttatatctt ttatcctatt 3298561 ttaaaaaagg gcaaaaaaag tcgaagatgc ctctgctctt cgattgatca cgttcctatt 3298621 tttatctgaa ttcagtgttc cagttaaaac cgatcgtctc atcatcccac ggaattcttt 3298681 tttcatcagg ctgatccggg ttatacgaca tggtggtaaa atagataatt gtcagcggcg 3298741 tctctcccag cactctatat ccgtgagcca ccccttttgg gattaataac agcatcgggt 3298801 tgtcttcgcc catataatag acgtccgttt ctccttttgt ctttgaatcc tctcgaagat 3298861 cgtataggac aacctgagcg tggccggttg ggaagaacca gagatcatcc tgcttctcat 3298921 gataatgaaa tgccttaatc acacccggat agcttttcga ccaagaggcc tgcccaaaat 3298981 gctcaaggag attctcatcg tcccggacca gctcagcaaa aaagcctctg tcatcgctat 3299041 gcttcatcaa ttttttcacc ttgactccat caatcacacg cactgctcct ttcctgcaaa 3299101 tactctcgta acgcttcccg ccagtggcgg gggcggatgc cggcttcttc aatagcccga 3299161 tggctcagca cagagtatgc cggacggggc gttttgttcc cgtattcctc tgtcgttaca 3299221 gacaaaatgg ctgtttccag cccgctttct tccataattg ccgtcgcaaa ctcataccag 3299281 ctgcatatgc ctgaattgct gacatgatag atgcccggcg gatggctgaa cagcttgatg 3299341 accgcttctg ctaaatcctt cgtataagtc ggcgaaccaa tttgatcgct gacaacccga 3299401 agctcttgtt tcgtttcagc aagtttcagc atggtttcaa cgaaattact gccgccatgt 3299461 ccgtacaccc acgatgtcct gatgatcgtg ctgtcttttg tcgttaatcg tatcagttct 3299521 tctccgagcc ttttgctttt gccataaatg gttttcggat cgaggggatc gtcttcccta 3299581 tatggctggg ttcctttccc attgaataca tagtccgtgc tgatatgaac atattgagct 3299641 ccgatgcggg ttgactcaag cgctgtataa taagcgccga ttccgttaat caagtacgct 3299701 ttatcaagct ctttctcgca ttgatcaacc gacgtaaacg cggcgctatt gaccacgata 3299761 tccggctgat aatggccaaa cgaatgccgt actgagcgct ggtcagcaat gttcatcatc 3299821 ttctttgtta acgcaatgac ctcatatccg gcttgcttca gctggcggca tagttccaag 3299881 ccaagctgtc ctcccgcccc agtcaccaat acctttgtca atcagatcac cttctcatcg 3299941 gtcattgtct gtataccact gaatcgtacg cgcaatgcct tcttcaaacg tcacttcctg 3300001 ccgccagccc agttcgtttt tcagctttga tgcattgatc gcatagcgcc ggtcatgccc 3300061 ttttcggtct tccacgtggg cgaacaattc ctcacagccc agatgcttca aaatgacact 3300121 cgccagctct ttattcgtgc gttcatttcc gccgccgatg ttatacacct cgccgtcggt 3300181 ccctttttct aaaatcagct tgatcgcgcg gcaatgatcc tccgcaaaca gccagtctcg 3300241 gatctggagt ccatcgccat acagcggaac aggcaggccc tgcttcgcat gacggataat 3300301 cgtcggaatc attttttcgc tgtgctgata aggtccgtaa ttgttgctgc atcgtgtaat 3300361 gatggccgga agcttgtggg ttttcacata agacaacacg agcaaatcag agcttgcttt 3300421 gctggctgag tatgggttat taggagaaag cggcgtcgtt tctgtaaacg cgggatcatc 3300481 cgcttttaaa tccccgtata cctcatctgt tgaaatatga atcagcttct tggcttttcc 3300541 tttcaagacc gcttccgcca atcggtatgt ccccatgaca tttgtggtga taaacggctc 3300601 cgcttgggaa atgcttctgt ccacatgcga ttctgctgcg aagtgaatga cgccatcgta 3300661 ggtctcgtca aaagcgcggt cgatatcctc ctgaacgctg atgtcccctt ttacaaagcg 3300721 aaaacggctg ttttgcttta atttttccat ttcctccggg tggctggcgt acgtcagttt 3300781 atctaaaacg gtaatgcgcg catccgtttc cctcagcatg agctttgtaa acgtgagccc 3300841 gatgaagccg gccccgcctg taattaaata tgattttgcc atcacttttc gtcctgtcct 3300901 ttccgtaaag cctggtgtac aagctgggaa gcgagataaa gcgattcgtg agttccggca 3300961 tctacccacc agcctgataa cacatcatac gtaagctggc tgttttcgat gtatagatta 3301021 ttcacatcgg tgatttccag ctcgccgcgc tttgatggtg atatttgttc aatatatgaa 3301081 aacacctctg catcatacat ataaatgccg gtaacacaaa ggttggtcgg tggctgttcg 3301141 ggcttttcga tgatggaacg aatccgcttg tttttctcat caatctcagc aatcccgaaa 3301201 cgttccgggt catcaacttc tttcagaagc acttttgctc ctttcccctg ctgttcaaag 3301261 cgttctgtat aaggctttaa tgaatcttca aatatattat cacctaataa taaaatgaaa 3301321 gactcttttt tcgtaaagcg ctttgcataa gacagcccat ccgaaatgcc cgatgctgcc 3301381 ggctgtactt gataagtgat agtaacgcca agctcttccc cgttcccaag cagtttgtaa 3301441 aattgcggca tatgctcctt ttggctgatg agtaaaatgt cttttattcc ggcttcctgc 3301501 agcttcataa tcgaccagta tatcatcgga tacgggccta caggaagcaa atgcttgttg 3301561 acggctttcg ttaagggcat aaggcgtgag ccgtttcctc cggctaaaat aacacctttc 3301621 acattaacac ttccttacat gcatttttat atctcttgtt catataaatc ttgaagaata 3301681 gctgttaccc gtataatgcc tttgccatcc acgagcggcc ttcctccctt gtgcaaagaa 3301741 aggcgaagag gatagctgct cataatgcgt gacatctgat agatgagtgt ttcatccggt 3301801 acaagctcac ccaatccaag atcaagagcg gcgccttggt cagcaaatgt tttggctgta 3301861 gccgtttgat gctcaacctg agaaagaaca aggcacggca cgccgatgca aatggcttca 3301921 tatagagaga tgccgccagc gacaatggct gcgtccgctt gtttcatcaa acctgccata 3301981 tcatttgtct gttcgatcat cttgtactgc ggcttctttt cgatccgcct tcggactgcc 3302041 tcttgatgcg gtgaagcgct ccccatcaca aacatcatgt ttttgtcttt tatgtcgggg 3302101 acttgatcag cggcagccag cactttaaaa ataagctgct tcggatcact tcctcctaat 3302161 gcaacaagga tattgcggca gtctttctta agtgtgtaat cctctcttgc ggcctgaaag 3302221 gcggggtgaa gaataagata gtccggacct tcatagatgc gtgtgtttcc ctgaacgtac 3302281 accctgcttc tgatgtcacc gtaaattccg ttaatgactg cgtcactata ttgaatcgat 3302341 ttaccgtttt tctcttcaaa aagaacaatt ttcgcatctg tctccgtctt tattttcttt 3302401 aacagctctg caggcgcgcc tagaatatca aacaaaagca aatcaagctt cttgcttttt 3302461 atttcccgga gaataaattc gtgctgctgc agctccggct ttacgatgac ctgccaatgc 3302521 tcttcatgaa gaaacgcttc agaatcctga ttcgtataaa acgtaatcaa gcatcgctgt 3302581 ttgagcccct ccgcaagcct cttcatccgg acaacatggc ccattccctt ttcatagccg 3302641 ccgtctgcga agatcccaac atgcatggct agtcagcctc tcgttcggtt gccgcatcgg 3302701 ggttccggtt cagaagggtg ataagctctg aggcggatac atcggggcgc tcgcctgctt 3302761 tttgatagag ggcctttatc gattcatagt cttcctttgt atcaatggtc agccgatatt 3302821 gaggggcgcg aaatcgttcc ggcgcctcta aaaactgaac acgataaaga gctggatgat 3302881 tccttatata taacgtgaca tgctcctgat attgatcctc caaagcctga atacggctga 3302941 tgtcaattaa caggttggcg ttgaccactt cgccgcaaat ccctaatggg gcattcagga 3303001 tatacgtata atccgagcct tgatcaaaat gcgcctgaat cattacatcg agcagctcag 3303061 gatcgacaaa cggattatca cctgttaacc ggatgatgac tgacggttta acagcttcta 3303121 tgaccttcac aaacctatcg aggacacgtt cttcgctccc gcggaaaaca cgaaagcctt 3303181 gtttgataca gtgcgcctct aatatgtcgt cagtttcttt gtcagacgtg gcgatgacaa 3303241 gattatcccg atccttttgg taaaacgcgc tttgccggac acggtgaacg agaatatcaa 3303301 gtaaacgatt cgatccgagc ggccgaagca cttttcccgg aagccttgtt gaacccattc 3303361 ttgcttgaat gataaagaga atatcattca tgaaacgggc tgtccttcag taaaatgtca 3303421 tcccagacaa tgcctgtgtc ggctggaatg tctcttacag cccgaacacc gctggtcagc 3303481 agttcaaaaa atctcgggtg cagcccctgc ggcttttgtc cgggccgaag cactgcgata 3303541 ttgtcttcac taaaggcttc acctttttga atcggagctg ttgtaaaaat gcctctgtat 3303601 gcaaagtttc tgatttctcc ttcgatggcg gtcgttgttt tgtatgaact gccaagcagt 3303661 ttttcagaga ccggctttgt gatcccctgt ttcagctcag cttccgtttt cctgatgcca 3303721 tcgaccattt ctttcaattc atccggattt aatgcaaacg agtggtcagc acccggcaga 3303781 tttttatcga tcgtaaaatg cttttctatc agttttgctc cgagccgaac cgcggcacac 3303841 ggcgcttctg tcggatgctc gctatgatcg gagaagccga ttaccgcctc aggaaaagcg 3303901 gcggcaagca tcggaatgac gctgaggttg ctgtactccg gcggtgctgg gtatttcgcc 3303961 acacaatgca ttatggcaat ttgattgttt ccctctgccc tgatggtgcg ccaagcttcg 3304021 tgaacatcag agatttcagc tccggctgtc gagaaaatca tcggcctgtt cagccgggcg 3304081 acatatttaa gcagcgggag atggttaatt tcataggatg cgattttaaa agcgctcggc 3304141 gaggtagact gaagcagatc agctgacccc tcgtcacata ccgtacttaa aaagatcacc 3304201 tgcttttcgc ggcagtaatc caatagcggt aaaatccact cagcaggcat ttccatagat 3304261 tgaaccaaag aaaaaataga gacgtccttg cccgctgccg tcttgtacaa accaggatct 3304321 ttctggtaca tcctatcagc ttggaacatt tgaaatttca cggcatccgc tcccgcttcc 3304381 gccgcggcgt ctatcagcgc aaaagcctga tcaagcttcc cgtcatgatt aatccccgcc 3304441 tcagcaataa taaaaacagg agcgtctttg cctacagttt tattcgcgat ctgaaacgct 3304501 gccattattt cgcctccttg cccggccaaa tatgataata gtaatacgat tgttcagcgg 3304561 tgaagcccat tcgttcataa aggcggatcg cccttacatt gtgaagctgc gtccccgctg 3304621 ttaccgttct atgcttctgg gtctccggtt gttctatgag attcgccaat aaatgaaacg 3304681 caatacgttt cccttcaaat cccggcttta cagccatcaa atcgagaatg cactcatcat 3304741 ctcttgataa gccctgaaga tagccgatga cctcgccatt gtgtttagcg acaatattga 3304801 ccgccgccct tccattcaga ttgtttcgtg tccactcctg aaatatttcg tttgctgcat 3304861 cgcggctgag atgaggatcc tgaaaatatc tgctttttgt aaacgagtct cgggccagct 3304921 cacatatcgc ttctgtgtct ccgggctcag gcgggcccag ttcaaaaaat ggcggtgttt 3304981 tgtcataaaa agacggaggc atcgccagct tcagcaaact cccgacaaag taagaggatg 3305041 gctgctgttg tatcacatgc gcggctccga tatcttcagc cggaacacgg acaaagataa 3305101 aatccgtttc atccatttgg cgtacagtat aaaaagcttc aaacagcctc tttagctgcc 3305161 cggtactatt tgccgcaaga agtttgacgt tcatgacttt cttctgaagc accttgcttt 3305221 cccacaaaga atcttcgtaa agcaatacgc cttggagcct gctgttttca aaaaggccga 3305281 gggaaaattg atacggaaca tccaatgtaa gctttctgct ttggagaaat tcctcaattg 3305341 cctctttgga gacattttct tttaccgtat acacttaatc agcccctttt acgatatccc 3305401 gcacagcttc aatgacatca tctacatcat cgtcagacat tgatggatag agcgggagag 3305461 aaagggttcg tttatagtaa ttcatggcat tcggaaagtc cgcttcctta tatccaaatt 3305521 gcttttgata atacggatga atgtgtactg gaataaaatg aacgctagtg ccgatattgt 3305581 attcatcctt taaagccgta atcatttcgc tgcgcgtaac cccggccttt ttttcatcaa 3305641 cttgcagaac atatagatgc caggcgtgcc tgccgtcatc atggacaaac ggcgtgatca 3305701 gcccaggaat ctgctgaaaa gcggtttgat agcggccggc aatctcttct ctccgtttct 3305761 gcatatcatc cagccgtttc agctgatgaa gtccgagggc cgcctgcaaa tcaaacatat 3305821 tcatcttata gccgggcgat tcgacttcat agtaccagct gccatttgaa gaataacggt 3305881 tccatgcggc tttactcatg ccgtgaaggc ttagcacccg tatcttatcg gcaagctcct 3305941 catcatcagt cgtcagcatg ccgccttccc ctgtcgcgag gtttttggtg gcgtaaaagc 3306001 tgaatgccgt tgcatccccg atagaaccga tcattctttg cttataagtc gtatataccg 3306061 catgtgccgc atcctccagc acgaataaac catgattttg ggcaacagcc aatattgcat 3306121 ccatatcgca ggactgcccg ccaaagtgga cgggcacaac tgctttcgtt cgcggtgtga 3306181 cggccgcctc aagctttacc gggtcaatat tgagcgtgtt ttcgtcaata tccgcaaaca 3306241 caggcgtcgc tcccgtatga ataatcgtat tggcggtcga gctgaacgta agcggagagg 3306301 taatgacctc gtccccgggc ccaatccctt ttgctttcaa agccaaaaat aaagctgcgg 3306361 tacatgaatt caccgccacg gcgtgcttcg ccccgacaaa cgcggcaaac tctttttcaa 3306421 actgctgaac cttcgggcct ttagagagcc atcccgattc aagcgtttct gtaacctcct 3306481 gaatttcttc cttaccgatt aacggcaatg agtaagggag aaaatgattt ctcttttgca 3306541 ccatttcttt gcgctcctat cattttattc agtatcttcc cgcctgtaat caacccctgt 3306601 tttggctttc agttccgcaa ataaagcatt tgttgattct gccaccggat aattagccgc 3306661 tatgaatgcc aggcgcgcct cttctgcttt ttgatgcacg tcgggacttc gaagaacctc 3306721 aaccaaggtg tgcgccagtt catccggctg gtcaaacata aaatcgccaa gagactcata 3306781 atacggatac gagcgatttc cggacgattt tcctatcagc acaggctttt gaaacagcat 3306841 ggcttcaaga ccgactgtcg aggtttgcgt cactgcggca tcaacatacg gcagcaaatc 3306901 ataaagctcc agctcctttt tgatgactct gcatgcttga tgttttttcg ccgcctcgtg 3306961 atacagatca agcttgtttt ttccgatttc ccacgggtgg ggtttgataa tgatttgcag 3307021 ctgcttctga tcagaaagcc cctgcagcac accggaataa aagtcttctg aaaagggctg 3307081 agtggcaatg agcacaattt ttttagtcgg ctgaaaagca agttttcgat agaatatgga 3307141 catatccata ggcgttctgt taaaaatctg atcgaagcgg ggatgtcccg ttacgagaat 3307201 ctgctcgggt ttacagcctt ttcgtatgaa ccactctgct tcatacgcac caaaaacagc 3307261 ttgataggtt gtaaaaacag gaatgaaggc ttcatctccc atcaatgcgc catgctgaag 3307321 acaaatgctg acggcccctt ttctttgaca catgagagcg agcaccctgc tgtaaatgtc 3307381 ttctgccgtt ccgacaataa cagctgaaat cttttcctgt tcaaacagcg catcaactgt 3307441 atcaatggcc tctataaata aaggaatatc tttgaaaagc cggtcgcgaa acgcttgatc 3307501 accaaatgcc gggtgatcat cataaggggc gagaagcgaa caggctgttt cgagatactg 3307561 cttcgaatcg cctttttggc atgaatccgc aatctcccgc ttgctaatta caggcagatc 3307621 acaataatgc ggcaaactcc atctggccaa aacagccgtt ttttcaggat caaattgata 3307681 gtaattttcg tttgaaaaac gcaggtaatc aaagtgcaaa atgactttcc ctttaacagg 3307741 ttcgtcattt gttttaacga tgttttggat tctttcttca aaaaacggct gaatctgtcc 3307801 ctcatcgata tgctgatcca ccgatccgaa taattccggt tcttcttcca tcatcaccct 3307861 cagttcaggg ctgatgtatt gataaaaatt actgataagc ccaagcggaa tccctttgta 3307921 gcgaagtttg tcaaaaagct ccacgtactt ccggtacagc acccaataat tgcttaaata 3307981 ggccgacaag ctctcacccc attccaagct tttttaatga ttcacgcagc tctcggcaat 3308041 ttcgctgcgg aggaaggttc ctgacaaatt catttttttc taattcaaac agctgaaagt 3308101 gaatcgattg gtcggtaata taattcaggt ccagctcctc atccagtggg taaaacggat 3308161 aaaaatgatt gactctccaa aagaaccggg catctcctat acggtaaaac gccgggcttt 3308221 catcccaata ggagccaaac ttctccttta ccttctcaag caccgaatac ctgtgcatca 3308281 ccgagcaatg atcaattgcg cacggcgcgt tccatgtcac ttgagcggca ggcctgacag 3308341 tttcttttac aatgtcacga ttctcgttta aatgataggt tttggaggct gagtaaatca 3308401 cagccttttc aggatgggta tcgagctccc gcaccatttt caggaggcgg tccggcatat 3308461 agatgttgtc atccgtcgca taggtgatat attcaccctc cgccatctca atcgcctgat 3308521 tgatcagtgc cgcgtatctc gttttttctg ttctttcctt cactccagat atatcgcttt 3308581 gataaaaacg cactcggtta tcattcaaaa aaggacggat tacattcagc gtctcttcat 3308641 tggagttgtc atccataata aacaattcaa aatctgaaaa cgtttgtgag agtatgctag 3308701 aaatggactt tgccacataa tcgcttttgt tatagctcgt cataatgact gatactttag 3308761 gcaaatccta cacctccttc ttggaacttc acacctgaaa ctatcgttat cttatgttgc 3308821 ttatgctcaa gttgcgctag ggatacaaac caatatgcga aaagtttgtg tatgtttctg 3308881 aaaaacagcg gctgcccaga gcgaaatctg atcggtccgc tgttcttttt cagcataatc 3308941 caagcatcag cctcataagg tgaaagagat aaaaatcgca ccagcgacta agatcgtttt 3309001 ccatcggagg tgagtcatcg cggagcgttc acctatacat ccagaacatg ttttgaatgg 3309061 ttttcataaa aaggaggaac gatatgaaac cgaaaaaaaa tcaatatcag caaatgcagg 3309121 catttgataa tatgcagggg tatcagcctc agtttggcgc caacccgtac ccgcagcaag 3309181 gccaaggctc acaaatgcag acaatgggga tgcagccaat gatgccaatg cagcagggac 3309241 agcaaggaca acaaggacag cagggatttg gattcccggg ccagcagcag ggcggcggtt 3309301 ttcaaattcc atcggggcct acaccgtcag gaccgggcca aagcgttccc ggcatgctgc 3309361 ctgttgagga atcttacatc gagaatattt tgcgcctgaa tcggggaaaa acggccacca 3309421 tttatatgac atttgaaaac agcaaggaat ggggctcgaa gatttttcgc ggcgtcatcg 3309481 aagctgcggg ccgggatcac attattatca gcgacccgaa atcaggaaca cgctacctgc 3309541 tcctgacaat ctacctcgat tacattacat ttgatgaaga aattgcttat acgtatccat 3309601 attccatggc gtcctattcg ccaagataag aaaaaagcca atcactcata tgatgaggat 3309661 tggctttttt gtttatagat atttgacggc tgcgacaacg atcataatcc aagaaataat 3309721 aaacgccaca ccgccgagcg gggtgatcgc tccaagaatg gagatttgcg tcacacttag 3309781 aatatataag cttccggaaa acagcacaat tcccgcaaac atcagccagc cggctgtcgt 3309841 gacactgcct atgccggata atttatcagc cagaaacgcg acaacgaata acccaagggc 3309901 gtgatacata tgatactgca cgcctgtgtg ccaaacctga agatacttat caggtatttt 3309961 cccttctaat ccgtgagcgc cgaatgctcc gagtcccacg gcaagcaggg cgttaatggc 3310021 ccctaatatg ataaaaactt tcatctatct ctcccgcctt ttcgttaaac tcatatcatt 3310081 tatcttatcg cacctgcacc aaaattcaat gtttgttctc cgttgacacg agattgtcgg 3310141 attttctcct gcgccaaagc tggaactggt cagctgctat tgcagcaagc gtccctaata 3310201 cgagcccgtt gcttaataga gaaataaata ccggatgcaa tccctttaac gcagtttcag 3310261 gaacaaacat gataccgacc cctgtcagca gtgagatacc gatgatagac ctcacccttt 3310321 ttgattcttc tttctcatat gaatcaaatt cggcaaaggc cagaccgccc attgcggaga 3310381 acacaacaaa attcaccgca aatccaacgg gtgacggcag gctcgcaaac gtattcataa 3310441 aaaacgggat cacgctgatc acgataacca gaatactgcc gagcataaac ggttttttag 3310501 aaggcatctt ggtcgtttca ataaaacctg cggctcccga aatcggaaca ggcgcaatag 3310561 ctcccgtcaa accgctaagc agatggctga atgaagctgc aaaaccggca tggcgttcat 3310621 gatgctttcc atcaggctgt ttgctgaatt ttttcatggc gatgtccacg accttcatgc 3310681 tcgccagcat attcacgatc agcaagatgg taataaaaat agaagtgatg atcaggccgc 3310741 tgttaaataa cggggtccca aaaggaaaca gggaaggcag ctgaaacagc cggtccggca 3310801 tttcaatcgg ctttgcggct ccggcagccg caaacagcac ccacccgccg aacaaggcta 3310861 ataaaataga atattgctta aaaaacatga tgttcgaatt tgtcattata aaagcggcag 3310921 cgatcacaac aagcgccagg ccaaatacaa gaccgtccac cccgtcctgt cgataaccga 3310981 ttccgagaat tccttttata atgggctgac tcagctgcat gacaagaagc aataaataga 3311041 cgcccgttac aaccggagta aacaattttg caagtctgtc aatgaccttg aaaacactta 3311101 acaaaaagaa acatacagcg cttacaagaa gagctccctg caaaccccgc agtgtgtctc 3311161 catatgtcgc aaacacagtt cccgtcagcc ctgcgtaaat cgtatacact ccccaccaca 3311221 agccggctgg gctttcattg atcggcagtc tgtggccttt caaacactga atgacggcgg 3311281 caattcccag tacaaaaaaa gtgctttgaa tcaatcttgc agaatctgag tgatccagat 3311341 gaaacgactg ggcaaccgcc accggaacaa caatcgccgc agcaataata aacgctgtcc 3311401 attgcagcgc gccaagaacc aatttcacgt aagctcaacc tctctcttta aaaatcaaat 3311461 aaagactctc cgtttccatc ctcttcctgc ttctcttttt cttgctttcg atatttgttt 3311521 aatcccgcgc tccccatcat tttttccatc atcagctggt ctgtcgatgg cggcgcggcg 3311581 ggacttggcg taacgctcgg ctgtatgcgg ggcgcgctcg cgttctccgg ctgatcaagc 3311641 acgacatcac acagagaacg gacaaccgct acataacgct tcagctcctc atcccgttca 3311701 gccgtttttg ctttttttag ctcttcttcc atcttttgaa tcaaagcaga tatatgaatg 3311761 ttcatgaagc accctccaaa aaaataaatg ttgtcttcct gcattttatc aaattcctgc 3311821 tgaaaacgca gatatgagtt tgttattttt tctgacaaac cttgcgcgat tgacaagcag 3311881 aagagatttt tcacataata aatcaccata ccttacaaaa aggagaaacg gaatgaacag 3311941 catcccctct atcatcagca agcataaagc ctattttgcg gcgggacata cgagaccgct 3312001 tgaatcgaga ctgaacattt tgcgaaagct gaaacaagcc gtcagaactc atgaagccga 3312061 tctcatagcc gctctctacc aggatctcca taaatccgag caagaagcat actcaacaga 3312121 aatcggaatc gtcttggagg aaatcagctt tgtcatgaaa cggctgagaa aatggtccaa 3312181 gccgaaacga gtcaaaacgc cgttgactca tctaggctcc aaaagcatca tcatccctga 3312241 gccgtatgga accgttttgg tgattgcgcc ttggaactat cccttgcagc tggcgctttc 3312301 tccgttgatt ggcgccattg cggcggggaa cacggtcgtt ctcaagccat cagaatatac 3312361 gccggctgtt tctgctattc tttccaaact catcagcagc gtttttccaa ctgattatgt 3312421 cgctatggca gaaggcgggc ccgatgtcag cacagcatta ttacagcagc cctttgacta 3312481 cattttcttt accggcagtg tagctgtagg aaaaatcgtc atggaggccg ccgccaaaca 3312541 attaattccc gtaaccttgg agctcggcgg caaaagtccc tgcatcgtcc ataaagatgc 3312601 tgacattcag cttgccgcca aacgcatcgt cttcgggaaa tttacaaatg cgggacaaac 3312661 ctgcatcgca ccggattatt tatttgtcca cgaggacatc aaaacgaagc tcacagaaga 3312721 aatgaagcgt gcgatcagag aattttacgg ccctcagccg gaacggaatc cacagtacgg 3312781 caaaatcgtc agtgagcgcc actatcagcg gctgctcagc tttctgaatg atggcatccc 3312841 gctcacaggc ggacaatctg atcccaatca tcacaaaatt gcgccgacca ttctcgaaca 3312901 agtgagagat gactctccag tgatgcagga ggagattttc gggccgattc ttccgctctt 3312961 tacataccgc aatatcgggg aagtcattga gaaagtccaa tcgcgcccta agccgctcgc 3313021 cctgtatctc ttcaccacaa acaaagaaat tgagcgcgct gttttaggaa atctgtcgtt 3313081 tggcgggggc tgtgtcaatg atacgttaat gcatgttgcg acgccgtatt tgccattcgg 3313141 cggcgtcggg gaaagcggca tcggcagcta tcacgggttt gacagtttta acacattcac 3313201 gcacaaaaaa agcgtcgtca aacaaacgaa ccgtttcgac ttcgcatttc gttatccttc 3313261 ctccaaaaac gggctgcgaa tgattcgaaa aatactcaaa taaaaaagcg cagatcacct 3313321 gcgcttttta caaatcctta atacaccaat caatcggcgc ctctcccatt ttctccaaat 3313381 aggcattcgc ccgggaaaac ggtctgctcc cgaaaaatcc gtttctcgca gaaaacgggc 3313441 tgggatgcgt cgattcaatg ataaaatgct tggaggtgtc gatccgttct tttttcattt 3313501 gagcatgccg tccccacaaa ataaagataa ccggccgctc tctttcactc agcacgtcaa 3313561 taattcggtc cgtcagtcgc tcccagcctt ttcccttatg ggaattcgcc tgtccgcgcc 3313621 ttactgtcag cacagtattc agcaaaagaa cgccttgctt tgcccagctc acaagcgacc 3313681 cgtgattcgg gatgctgcac ccgatgtcct gctgcagctc aagaaagata ttttttaacg 3313741 aaggcggctg ctttacaccg ggcttgacag agaagcttaa accttgagcc tgtcccggcc 3313801 cgtgatacgg atcttgaccc aaaatgacga ccttgacatc atcatatgat gtataatgca 3313861 gcgcgttgaa aatatcccgg ctgtccggat aaatcgtttg ctccgcgtat tccctcttca 3313921 gcatctctct gagctcttga taatacggtt tctcaaactc ttcctttagc tgattccacc 3313981 agctgtcttg taaaagctgt ttcaagattc aggcctcctt acgaacgatg aagtctggaa 3314041 tagacaggct cgccatccca aaccatttca ctttttgctt cccgcctctt catctcaggc 3314101 tcttcaagca ggacggcaaa gtttttcgtc ggcagctccc cgagtccgtg cttttcactt 3314161 aaacgatcca aatattgctt ccgcttggcg ccaaggtcag cagactgatt gtctcccgcg 3314221 tcactgaagg cataaatcac gctggcgcaa gggacacgct tcacccggta atccttggcc 3314281 gcgcgcaaat aaaaatccca gtcccagtaa ttgtgcacat cagcatcgaa atacccgatt 3314341 tcatcatgca gaaaacgtct gtacatgctg cccgacggca cgtatgtaga aaacactctc 3314401 atatcctcat agtcagcggt ataagcaaac aatttccgtg acactggata ccttgttccg 3314461 tttttctctt caaacgaaac tatttccgca tcagaatgaa cgaagtctgc cgtttctatt 3314521 tcctttgcca ttttctcgat atgccctggc gtaaagaaat catcgtcatc acacagcata 3314581 atgcaatccc cagacgcctc ttttacaccg gcatttctcg cagccacatg ccccgagttc 3314641 ttttctaaat tgatgacagc aatcggcagc tccggataaa gtgctttgac cggcacgacc 3314701 gattccccgg catcattcac aataataatt tcatacggca tcaaggtctg gcgggaaatc 3314761 gactccaaaa gctcacacaa agccggaatc cgattatagg tcacaattac gatagaaatc 3314821 ttcatgatgc tctccttctc attttcatag tcatgtacta ttaaaacata tattggacgg 3314881 gagatcagtg ggaatatcct actgaaacgg catactacaa tgatagaaac agcaaagtgg 3314941 ctccgatcag aagcaccatg atcagcatca gatctccaaa gacatgaaag atatctttca 3315001 tgcggacgcc attcggaagg ataagacgcc acagcttaga ttgatagacc ggcagcagca 3315061 ccagtgcata agaaagacac aaaaatgtaa aagccggcgg cacaaaagca cagcctgcat 3315121 cgtcccaatt catcatgatg tctttcatac tagatccatc caataaaaac aaagatatca 3315181 tgagggctag caacacaaag gaccccaatt gaacctcaaa caggcgcatt ttctggttat 3315241 atgcaaatcg gaccgcccaa aaccagacat aagcatatga acatagcagc gtaagaatgg 3315301 cacctgctgt aaagacgaca tcaggcagcc gatcaagcag aaaaacaaaa ggcaagctgg 3315361 ctgccatagc caagagcatg cagccaccag taaacaaaaa tactgcccca tgagctacaa 3315421 aaccatataa acaagagcta atcctcacga catacacctc ctttacatag aaattctatg 3315481 tatataccta aaaaatcaga caagctgacg cctgccaata taacagccca ttcggccaaa 3315541 taacggaaat aacagcgttg caaaagcaca agttccaaca aaccaaggtg tcaacaagga 3315601 ttgaaacagc gcagcaggaa ttacattgaa tagaaaaaca agcataaaaa tgacgtttgg 3315661 caccattgag atcagaatcg tatgtagaac aagcttttct ccgcgttttc caaactcctt 3315721 cacgccttga tacccaatca gcacccagta gatcatatat gcagctaaga tcagccaaac 3315781 agaaacagaa atgcctttcc atactgcttg aacaaacggt gattcaagcc atacatgcat 3315841 tattgtaatc gcaatgccga cagcgaatag ggcactgtta cagaaaagat ggaacatcaa 3315901 aaacgcacga aacgttactg gctgtatttt cttaaacgaa gaaacaatgt cagttggtgt 3315961 tccaaacgcc tgcaataaag tctgcatagc ttcctcctca ctctttcctt cctgaaaaga 3316021 gcgaaacaga tgatgttcaa tatggctctc aatctcttct atcatcgcct caccctcagg 3316081 aagcccttta agcccgcttt tgatttcgga tacatatgtt tctttatcca ttttgtccgc 3316141 tccacttcag tattcggtcc atcatggctg aaaatacgct ccattccttc gtgcgttccg 3316201 ccagcacttc tttgccctcg tctgtaatcc ggtaatattt gcggtccggt cctttctcct 3316261 gcttctccca gtaggaagaa atataccctt ggcgttcaag cttgtgaaga gaaggataca 3316321 aggtcccttc tttcatctgc agttcatttc cgctgcggct tcccatttct tttacaagct 3316381 catagccgta catcggccgc tcgttcagaa gcgtcaatac caatataacc gtgcttccct 3316441 taaccagctc acgatttaac atctcaaaac ccctacctag ttttcttatg tagcatttta 3316501 cgaaagcccg ttgagattgt caaatgattc ctatagatct tctatattgt gatacagaga 3316561 aaatctaact ataatgaaag acaaaacatg atggaggttc aagacatgtc tatgcataaa 3316621 gcactcacca ttgccggctc agattccagc ggcggtgctg ggattcaagc tgatttaaaa 3316681 acatttcaag aaaaaaacgt atacgggatg accgccttaa cggtgatcgt tgcgatggac 3316741 ccaaacaaca gctggaacca tcaggtattc ccgatcgata ctgatacaat ccgcgcccag 3316801 cttgcaacaa ttacggacgg catcggcgtg gacgccatga aaacaggaat gctgccaacc 3316861 gttgacatta tcgagcttgc ggcaaaaacg atcaaagaaa aacaattaaa aaatgtggta 3316921 attgacccgg ttatggtttg caaaggtgct aatgaagtcc tttatccgga gcacgcccaa 3316981 gccctgcgtg agcaattggc tccgctagcc actgtcatta cgccaaactt gtttgaagcc 3317041 agccagctca gcggcatgga tgaactaaaa acagttgacg atatgatcga agccgcgaaa 3317101 aaaattcacg cactcggcgc tcaatatgtc gtcattacag gcggaggcaa actcaaacac 3317161 gagaaagccg ttgatgttct ctatgacgga gaaacagcgg aagtccttga aagcgaaatg 3317221 atcgatacgc cttatacaca tggcgcaggc tgtacattct cagcagccgt gacagcggag 3317281 cttgccaaag gtgcggaagt caaagaagcc atttacgcag cgaaagaatt catcacagcg 3317341 gccattaaag aatccttccc gctaaaccag tatgttggtc ctacgaagca ttctgcactg 3317401 cgcctgaatc aacaatcata aaaaaagggg ctgccttaca gagaggcagc cctttttaaa 3317461 tcaccgaaga cttttcacag aaaaaactgc cgatcccatc ggcagcctgt ttatttgatt 3317521 tttaaattgt ttgcagattt cctcaaaaat gtttctatcg actgaacaaa aagtgcatat 3317581 tccttcattt gttcatatgc ccgcgtgaga atttccgccg tttcactgtg cggcgttgtt 3317641 ccgccaagca tttttttcag ctgaagcagc acatccttat attcttctcg cttatcttca 3317701 acttggttag cagccttttc caaacattcc ggtgttatct tctgttcatg tatattcaag 3317761 aaaacaactc cttttacaga aaaaaatagt aggttatcgt tgaagaatag cacagatggc 3317821 tcagatttca cataagaaaa tagaaggatt ttctacataa gtgtccaaat tccgacattc 3317881 atttcagatt tcccggtcgc actggctgtt acttcatgat ttcccgggaa aggaaaatat 3317941 cttgcactca agacctcttc tccgttattg ataaagattt ccacagatga cgcgtcgaga 3318001 aacatgtgta cggtatgcaa atccttgatg cggcaatgtc tcgcttctgt tctttttccg 3318061 tcaaagctct ttcgttccag cgtaacaatc ccctcgtctt tatggaagga aaacgtagcc 3318121 gttccgcgga tactgattga aaagccagac tccgtatgaa tgtcttccag tagaatctca 3318181 gttctttcag gtttttccac tggaagcgca ccagatgatc catgcatgtt gatgtgtatt 3318241 tttttctcat ttctgcgcat ggcttttagc tcaggcagcg gctgctgaat cagcttctgt 3318301 cctgaaagcg tcagctgtct cggcagcgtc atgcagtgaa tccagtggca gtcaatggtc 3318361 ggatgggacc cttcatcctg atcaggcacc gccatccatg caaataaaat ccgccttccc 3318421 tgatcgtctt caagtgtttg cggcgcgtaa aaatcaaaac cttgatcaag ctccgtaaat 3318481 tcaccatgct tcagttcagg cttgttataa tcgaggcggc cgacaaaata acctgattga 3318541 tatacgttct gataacggaa accgtcagcc tcaagccctt gaggcgaaac aatcagcaca 3318601 tccgatcctt gaagggaaaa caaatcaggg cattcccaca tgtatccaaa atcgtccagc 3318661 ccgttgaagc ccgcgccggt tatcgggcca agaaatctcc actctgtcag gttatcagaa 3318721 gcaaacaaca cagcctgccc tttcaaattc tctgtttgcg caccaatcac catataccat 3318781 gtgccttcat gctcccatac cttcggatcg cgaaaatgcg ccgtatatcc ttccggaagg 3318841 cgggcgacga cacccttttt ctcaaaggac agcccgtcgt cagaaacagc aaggcattga 3318901 tacgtttccc gatttccatc ctgatccctg acatttcctg tgtaaaaaag atagagccga 3318961 tcgtctttcg tgacagcgct gcccgagtag cagccgtttt tatcaaacca atcactcgga 3319021 gccagcgcaa tctcttcccg cttccaattc acaacatcct gtgtcgtata atgcccccaa 3319081 aattttgcgc cgtgccccgt ctgaaacggc tgccactgaa agaatacatg atagctgccc 3319141 ttccaataaa tcacgccatt cgggtcattc agcagcccaa ccggcggcat gatatgaaaa 3319201 tgctggcggt gcggatcgct gttagcgatg ggctcttttt tctccacttc ttcataagcc 3319261 cggcgacgaa gctcctggtc atgtgctgtc attttttcct ctcctcatcc tcattaatct 3319321 tcatgacaaa tgctgcaatg aacgctgaca ctgccgcaat cgccatgcca atcagatagt 3319381 gaatcaagtt gctgaagcca aacggagccg caatggcgat catcggaatt cccgttaacc 3319441 cgtaagcgtt tgcagctaca tgtgtaaaga cgacatatgc cccacccaat gcgcctccga 3319501 tcatcgcggc gataaacggt tttcggtagc gcagattgac tccgaatatg acgggctcag 3319561 taatgccgag aaaagcggaa aatgctgccg gaagcgcgat ttcttttgtc tttgcctttt 3319621 tcgccataaa gaagacggca agacctgccc cgccctgtgc gacattcgcc attgaccaga 3319681 tcggcagcaa gtagtttttg cctatatctg caattagccc tgcctcaatc gcatggaagc 3319741 tgtgatgaac gcctgtcagc acgatgagtg aatacgtgcc cccgaaaatc agacctgcga 3319801 caaaaccggc atggtcatat acataagtta aagcaaccgt aatgccggag ccaagcgctc 3319861 tgcctagagg gccaatcgcg ataaaagcaa caaacccggt gacaatcaca gtaacaaatg 3319921 gtgtaacaag caaatccacc gcatgtggaa ccacttttct cgtccatttc tctaccttgc 3319981 tcatcacata caccgcaagc aggacaggga taacagttcc ctggtagccg agaagagcga 3320041 tatcaaatcc gaaaagatgc atgtaatcag gtgtcgcttc cgccaatccc catggattta 3320101 aaagattcgg atgaatcatg attcccccga tgaccgctcc caagtatgga ttgctgccaa 3320161 actcttttga agcgctgacc ccgattagaa tcggcaagaa aatgaatgct gcacttgaaa 3320221 acatatcaag cagctgcaaa agcgcagaat ccttgctcat ccaatgaaac gcattgatca 3320281 tacccagcaa tcccattaat aggccgctgg ctacaatagc tgggatgatt ggaacaaaaa 3320341 tattagaaag cgttttcgca aatctcgcag cgggattcag cttttctttt gccgcatcct 3320401 gatgattgac gtgttcttca cgctcgatat cagcttcttt agaaaaggca tcgaatactt 3320461 tattcacaag gcctgttccg aaaatgatct ggtactggcc agagctgctg aaagcccctt 3320521 taacgccatc aagctcttct acttgtgctt gatctatctt tgattcatct ttcatcacta 3320581 aacgcagtct tgttgcacaa tgagccgcgc tgataatatt ttctttccct ccgagaagct 3320641 caatgaggcg ttttgcagtc tctttgtaat ccatctattt ctcccccttt tatttaaaca 3320701 aaaaagacct aaaattcgcc aacgaataaa ggacacagcg atcctttttc atttacgcaa 3320761 attttaggtc ttgcctgctt taccagtcac aatcccgctt attcagatta agaatacgct 3320821 ttcatcataa atcatgatag cgttttcgtc aactattttt ttagttaaat agtttgatat 3320881 aacatgtaga caaaaattcg taaaaattaa ttgtgaaata cttcacaata tcgtgctata 3320941 ctatgctcaa tcatgaaaga aagcaggaaa agacaatgga aactcaagca ttacaaaagg 3321001 ttgaacagta tgctttgaaa aaacaaaaca tattcgcttc aagcaaaatc cgttatgtgc 3321061 ttcggtccat tttggccagt atatttattg gttttggcat tacagccgca agcaaaacag 3321121 gcagctattt ctttatggct gattctccgt ttgcctttcc ggcagccgct gtcactttcg 3321181 gggccgctat tctgatgatt gcttacggag gcggagattt atttaccggc aacacctttt 3321241 atttcaccta taccgcgctc cggaaaaaaa tcagctggcg cgacacccta tacttgtgga 3321301 tgtcaagcta tgccggcaat ttaatcggcg ccattctgtt tgccatcctg atcagcgcga 3321361 cgggactttt tgaggagcct tctgttcatt cctttttgat tcatttggca gagcacaaaa 3321421 tggagccgcc ggcttccgaa ttgtttttca gaggaatgct gtgcaattgg cttgtgtgcc 3321481 tcgccttttt cattccaatg tctctcaaag gggaaggagc aaagcttttt accatgatgc 3321541 ttttcgtttt ctgcttcttt atttccggct ttgaacacag cattgccaat atgtgcacat 3321601 tcgccatctc gcttttgatc gagcaccctg atacagtgac actgatggga gcagtcagaa 3321661 acttaatccc cgttacgctc ggcaatctga ccgcgggaat agttatgatg ggctggatgt 3321721 actacacact gaatcctgat caataaaaaa acttccagag atcactccct gcaagtcaaa 3321781 gcggttattc cgagagatct tgaagacgct ggacatgcag cgtgatatag ccggcctcgg 3321841 attccggcaa atgtaattga tattcatttt tcaaaaactc cgccagctcc agcgcacatt 3321901 gataggcgaa tgaatacttt ttttggatga aataaagcat ctcctcgtcc atacgatgga 3321961 gcgcttcatt tgattccaac cggctgaccg cgtatcgcaa atgcgtgaca aggcgttgat 3322021 aggaaatgct gttttcatcc acctttcgat taaagtattg ttttattttc tctatcattt 3322081 ctttgatcat ggtcgtatgc ttcagcgctg aatacatgct ctccgcatcc atcttcgccg 3322141 tatggatgtg aagggcaata taacccgctt catcttcagg cagagacacg cccaatgtct 3322201 cttttacatg tccgatcgcc cacaggccga tctcatattc ttttttatag agcgccttta 3322261 tctcatgcag caatttattc tgcacaagca gcccattttg aatcctttcg atcgcaaagg 3322321 acaaatggtc ggaaagcgcg atatgaatgt gatcgctcag cggcgccgcg agctctcctt 3322381 ccgcatagct gatgatatcc tcagctattt ctatatgctc ctccggcagt gtttgcagga 3322441 tttgtttgaa cttttcattc tcgtcgcgca cgacaaagat cttttccact ttattcatag 3322501 ggatgagatc atttttcttt ttttgaaaag cgattcccgg tcccatcacg attttttcct 3322561 gatcatcctc ttttattaaa gccgcattgt tgtttaatac tttatagatt ttcaagaggt 3322621 tatctctccc gccaatttgc ttttgactgg gattttacct ccttttgacc gccatgtaaa 3322681 gatgcgggcc cgctctctcc tgctttggcg attccttgaa ggcttgcaaa catcttcttt 3322741 tataaagcgc ggcggctttc gctttctgct tttcttcctc attcacagcc atccgccatt 3322801 cataaaacga aacgagtcct gcggcctgca cagccgcctt tctttggtat gtacgctgag 3322861 ccgaatagac cgcggcagcc gcagtttttc tgtccggcgt cacccagttc atcaaaaaga 3322921 ccatccacac ccgtaaagat acaagcaaac gtttcataga aaaacatccc tccgcttctt 3322981 tttggcaggc agccttttta gcagcccgtt ttctcagccg cagcccgcaa gaaaagacgg 3323041 ccgatttctt ttctcgcaaa ctagcggctc tagcaaaact catgactcta tgatagaccg 3323101 tggaaagaga attctttgtc acaatatgag tgaaaaaacc aactagtttt tagaagtttt 3323161 gttgaaagct gaaagaattg aaatgaaaat tggagaaccg ctttgaaaac tttatacaca 3323221 agttatccca aagataagaa caacttaatc acaagagata tccacatgtc cacaaactct 3323281 atctatattt tgtatacgaa cgtatattcc taactatata tatacacagg tttattcact 3323341 tatacacagg gttctgtgta taactccttc gttatacaca aacaaaatcc aataaatggt 3323401 ccaaatgaca caaggatttt tttgaatttt caagaaatat atactagatc tttcacattt 3323461 tttctaaata caaaggggga aacacattga aaaaggggat cattcgcttt ctgcttgtaa 3323521 gtttcgtctt attttttgcg ttatccacag gcattacggg cgttcaggca gctccggctt 3323581 cttcaaaaac gtcggctgat ctggaaaaag ccgaggtatt cggtgatatc gatatgacga 3323641 caagcaaaaa aacaaccgtt atagtggaat taaaagaaaa atccttggca gaagcgaagg 3323701 aagcgggaga aagccaatcg aaaagcaagc tgaaaaccgc tcgcaccaaa gcaaaaaaca 3323761 aagcaatcaa agcagtgaaa aacggaaaag taaaccggga atatgagcag gtattctcag 3323821 gcttctctat gaagcttcca gctaatgaga ttccaaaact tctagcggta aaagacgtta 3323881 aggcagtgta cccgaacgtc acatataaaa cagacaatat gaaggataaa gacgtcacaa 3323941 tctccgaaga cgccgtatct ccgcaaatgg atgacagtgc gccttatatc ggagcaaacg 3324001 atgcatggga tttaggctac acaggaaaag gcatcaaggt ggcgattatt gacactgggg 3324061 ttgaatacaa tcacccagat ctgaagaaaa actttggaca atataaagga tacgattttg 3324121 tggacaatga ttacgatcca aaagaaacac caaccggcga tccgaggggc gaggcaactg 3324181 accatggcac acacgtagcc ggaactgtgg ctgcaaacgg aacgattaaa ggcgtagcgc 3324241 ctgatgccac acttcttgct tatcgtgtgt tagggcctgg cggaagcggc acaacggaaa 3324301 acgtcatcgc gggcgtggaa cgtgcagtgc aggacggggc agatgtgatg aacctgtctc 3324361 tcggaaactc tttaaacaac ccggactggg cgacaagcac agcgcttgac tgggccatgt 3324421 cagaaggcgt tgtcgctgtt acctcaaacg gcaacagcgg accgaacggc tggacagtcg 3324481 gatcgccggg cacatcaaga gaagcgattt ctgtcggtgc gactcagctg ccgctcaatg 3324541 aatacgccgt cactttcggc tcctactctt cagcaaaagt gatgggctac aacaaagagg 3324601 acgacgtcaa agcgctcaat aacaaagaag ttgagcttgt cgaagcggga atcggcgaag 3324661 caaaggattt tgaagggaaa gacctgacag gcaaagtcgc cgttgtcaaa cgaggcagca 3324721 ttgcatttgt ggataaagcg gataacgcta aaaaagccgg tgcaatcggc atggttgtgt 3324781 ataacaacct ctctggagaa attgaagcca atgtgccagg catgtctgtc ccaacgatta 3324841 agctttcatt agaagacggc gaaaaactcg tcagcgccct gaaagctggt gagacaaaaa 3324901 caacattcaa gttgacggtc tcaaaagcgc tcggtgaaca agtcgctgat ttctcatcac 3324961 gcggccctgt tatggatacg tggatgatta agcctgatat ttccgcgcca ggggtcaata 3325021 tcgtgagcac gatcccaaca cacgatcctg accatccata cggctacgga tcaaaacaag 3325081 gaacaagcat ggcatcgcct catattgccg gagcggttgc cgttattaaa caagccaaac 3325141 caaagtggag cgttgaacag attaaagccg ccatcatgaa taccgctgtc actttaaagg 3325201 atagcgatgg ggaagtatat ccgcataacg ctcaaggcgc aggcagcgca agaattatga 3325261 acgcaatcaa agccgattcg ctcgtctcac ctggaagcta ttcatacggc acgttcttga 3325321 aggaaaacgg aaacgaaaca aaaaatgaaa cgtttacgat tgaaaatcaa tcttccatta 3325381 gaaagtcata cacacttgaa tactcattta atggcagcgg catttccaca tccggcacaa 3325441 gccgtgttgt gattccggca catcaaaccg ggaaagccac tgcaaaagta aaggtcaata 3325501 cgaagaaaac aaaagctggc acctatgaag gaacggttat cgtcagagaa ggcggaaaaa 3325561 cggtcgctaa ggtacctaca ttgctgattg tgaaagagcc cgattatccg agagtcacat 3325621 ctgtctctgt cagcgaaggg tctgtacaag gtacctatca aattgaaacc taccttcctg 3325681 cgggagcgga agagctggcg ttcctcgtct atgacagcaa ccttgatttc gcaggccaag 3325741 ccggcattta taaaaaccaa gataaaggtt accagtactt tgactgggac ggcacgatta 3325801 atggcggaac caaacttccg gccggagagt attacttgct cgcatatgcc gcgaacaaag 3325861 gcaagtcaag ccaggttttg accgaagaac ctttcactgt tgaataagaa aaagccctgc 3325921 cgattcggca gggcttttta aagatcagtc agcaaacgcc tcctgcaata agcgatacga 3325981 tcggagctta tcttcaaaat gatgcgtgat ggtcaccacc atgatttcct ctgtttcata 3326041 cgcgttactc aaagctaaca gccgctcctt aacctgttct ttcgtaccaa caatcattcg 3326101 atttcgatta tcagcaattc gtctctgttc ataaggagaa tacgtatttt tccgaacagc 3326161 ttcatacgaa ggaactccct ctaaaggaat accctgctct cccgccaaaa gtgtaaaatc 3326221 aagcacagcc ccaagctcct ctgccttctc ctccgtgtca gcacaaagaa caaaaacagc 3326281 aactgccgct cgaggcgtat ctcctaacac agacggtttg aatcgcctct tatactgtct 3326341 gacagtaccc tctccgccct ctccattgat aaaatgggca aacatatagc cagcgccaga 3326401 ttcagctgcg agcagcgcgc tttctccaga tgagccgagc agccacacat ccggagccgt 3326461 tgaaatatgc ggcgcagcgg tcagattcgg aaaacggtgt ttgtcatccg ccaaatcatg 3326521 caaatacatg gtcagctcct taatttgctg cggatactga tcagcattgc gcttaccacc 3326581 gtcattcagc gcccatgatg caatcggcat tccccccggt gctctgccaa gccccaggtc 3326641 aattcttcct ggtgtcagcc cctccagaac acgaaagttt tcagctactt tataagcact 3326701 gtaatgcggc agcatgactc ctcctgatcc aacacgaatt cgctttgttt tcgctgctat 3326761 atgactgatt agcacctcag gactggaccc tgccagccgt tttgaaaagt gatgctcaga 3326821 aacccaaaat ctcttatatc caaggtcctc agcagcttgg gcaagcgcaa cggtttgctg 3326881 taaggccgtt tctgcattgc tgccctctga tactggagat tgatctaata tacttaatga 3326941 aaccatccct accacctcat cctcatcgta tcactgatcc cctatttttt ctccaaagcc 3327001 gctcacactg cttatcagtg tcccctatca ttcgccattt atttgtgaaa gcatgtccct 3327061 atttgtcgga atatgttaca cgtgaaacat aaaaacccct ccagacggag aggtttgctt 3327121 tagtttttat taaagccctt ttctttcacg tagtcattta aatacgtacg cggcttttgc 3327181 ttcataaagt tcagtatttg atcggaccac gtttcttccc gcttcccgtt tgttctttct 3327241 ctatagtaat cagaaatggt tttgtcatac gtattcatag tatgacggaa atcgtctgtg 3327301 ttcacattat acgtattttc atgataaacg gcctgctttg gcaatctcgg ttttttgccg 3327361 gaaaggttcg caggatggcc tactgccagt ccgaaaagcg ggagcacatg gtcaggcgtt 3327421 tgcagcacct ctgtcacctt gtccaattca ttccgaatgc cgccgatata gcaaatgcca 3327481 agccccatgg attcagcggc aatgctcata ttttgcgctg ccagcgccgc atcaatcaag 3327541 ctaaccataa acatttctgt attctcgagc agctcagaaa tatgttcacc tttttcctca 3327601 gccagttgtt gatggcggta caaatccgca caaaatacaa aaaagtgtcc gttcttctca 3327661 acgtaaggct gattcccagc aagcacggac agctcacgtt ttttctcagg atcagaaacc 3327721 ccgataatcg aatatgcctg cacatagctg gatgtagacg cagcctgcgc acttttcact 3327781 aatgtatcaa tttcttcagc tgtcaaaagc tgatcagtaa aagaccggat tgaccgatga 3327841 ttcaaaatgg tttcgattgt gttattcatc acaaaaacct ccttatcact ttttatcata 3327901 tccgaaaaaa agtgatctca aaagtgaaat gctctgcaca aaaaaagaca gcctctgtaa 3327961 aggctgtctg catatcaaga attaaaaaga taacttctgt atttcgtcag ctgcacactt 3328021 gcattatata caatcccaaa tccgattaac gtggaaagtg tcgagcttcc cccatagctg 3328081 acaaacagca gcggaatccc ggtaacaggc ataatgccaa tgttcattcc gatattctgg 3328141 aatgtgtgga tcacaattaa cgccgtatag ccaacgcaaa agaaagaagc gaaacggtta 3328201 aacggatgta ttttgtctat cagaacaaca agcctgtaga ttaaaaagaa gaacatgatg 3328261 acaacaattg cacagcctat aaagccaaat gactcaccta ttatagaaaa gataaagtca 3328321 gtcgtactct ctggaacata aaccttcaaa ttagaaatac cattacctaa aataccacca 3328381 gatcctattg ccatgatggc ctggtcaact tgccagctgt catttgaatc ttcctgtgtc 3328441 tcatttgaag cagacaccca agaagtgacc cgcttaattt gataatcctg tattccaact 3328501 gatttagcaa cgtcaggaaa gtttatcatt actaataaaa ttaatgaaat gagtaagata 3328561 cctgaaccag ctatgatcgc aatcaatttc caatttatcc ctgacataaa aaccattaca 3328621 agaacgataa acatacatat tcccgcagtc ccagcatcct gcatcaggat aagacctaca 3328681 ggaataactg cgacacccgc aatctttaat aacaagtgga tatcatccct aagcgtccga 3328741 actcctttag gatttgcttt tccaataact gaagcaagca tcataatcaa accaaccttc 3328801 ataaactctg acggctgtat tgttattcta ccgatcctaa accaactttt tgccccttta 3328861 ataacaggtg caatagactc gggactgatt ttaagaataa tcaaagataa aataccaatg 3328921 ataaaaatat ataaacttaa cttttcaagc tgttctaaat caaagtacaa aagaactgta 3328981 atggctacag cccccaaaag ataaaacaca atttgctgaa tccaatccgt gttcccatac 3329041 tgcccaaact gaccggcagc atatattgat actacgctta taataaaaaa cacaccaaat 3329101 ataaaaatca aatccccctg gtaaaagggg ctttgctgtt tcttatatcg actcattcta 3329161 tcccgcctta cattttcatc ggaaaatcac taatgtttat tatacatgaa ccacgttcaa 3329221 gatgacacgt gaagctcgct tccttttatg ttttttcagc atttgcggcg ctttttcagc 3329281 tacacgaaat atgacgtatc ataaaccgaa atgtttcgat tgacacaaaa cttttcaaat 3329341 gaaaaaaacg ccataccaat agaatttgtt aaaaaacgaa tgcgataatg tgttatgttc 3329401 ccaaataatg tgatacctca tatagaaata gctaaaaatt cagagcccca tgcccataca 3329461 ttctcctagc acattaaacg aaaaaataag acgatagatc cagtccattt ctgcaaaaac 3329521 acgtatcaat ttctggaaaa catggtataa taattgtaac agaatgttca aaaaacaatc 3329581 acaaaacaga cacaactcag ttcctctatt tcatttttgt aaacgttatc acaaaatgaa 3329641 aggagacggg tatgatggac atgttttttg cttacttatt ggttgccagc gcaacgcctc 3329701 tctttatttg gcttgataac aaaaaagtcg cactctcagc tattccgcca atcattttaa 3329761 tgtgggtatt cttcttcttt tacgcaacag aaagcctttc tccacttgga cacactctca 3329821 tgattatctt gtttgccgtt aacgtcattg tcgctcatat cgccgcattt atcatttacg 3329881 gccttccgta tcttcgcaga aagcgaagca gctgaagaca gcaaaaaacc ctcttccact 3329941 gaagagggtt ttttgtatta ttcgttatgg cctgaatgct ctgagtgttc agcgcctcca 3330001 ggaggatttc cgtccatatg gtcaccatgg tgatagtgag ccgcgaaaat ccagatggat 3330061 ccaagtacga taacgatcgc gccaaagaat ccgaacagcg tgtttccgac ttggatcgtg 3330121 ccgttttcgc tctctgtcat atgcatgaac atgagaagct gcagcgccgc ctgaatgaag 3330181 gcgaagccga agataatcca aagttttgct gatgagctca ggtcagtata cactgcaacc 3330241 catagagcca gcagggtcaa aacgatagac aggataaaac ctacaatgtg tttccatgga 3330301 aagtgactgt gttcagcaga tttgtttgcc attttacaga ccccccaatc ccatgagata 3330361 gacacctgta aagatgaaaa tccatacaac atctaagaag tgccagtaca agcttgagat 3330421 aaagatttta gatgaagttt gcggagttaa gccgcgtttc ttcaactgaa tcagaattcc 3330481 tgtgatccag aaaatcccga ttgttacgtg agttccgtga gttccaagta aaacaaagaa 3330541 tccagaccag aacgcacttg tactgagagc cgctccttca tgtacatagt gaacaaactc 3330601 gttgatctcg catccgacga agccggcacc gagaagaaga gtgataattg tccaaatgac 3330661 tacgcctttt aaacttccgc ggcgcatttc atgaacagcg atcccgcagg taaagctgct 3330721 gatcagcagc aagaacgtca taatcattac cagattgact tcaaatagtt cgtctggcaa 3330781 gacacctcca gctgttctgt ttttaagaac gaagaaggtt gcaaatagtg ttgagaacaa 3330841 cacaatttct gcccctaaaa agatccaaaa cccgagaata ttaagtctgc cggtttcaga 3330901 ttgatattcc ataggcgcgt tagaattgcc gtgttctgca tgttccataa ctcacgcctc 3330961 cttattcgga aatctttctt tccgtctctt ttatttcatc aacactaatg tagtagccgt 3331021 tgtcgtattc gaatgaacgc agaaccatgc agagcaggac tccgatcaat ccgactacgc 3331081 ccatccagta ccattcaaag acaagtccaa agcctgcgag accgaaggca acagacataa 3331141 agaacggtct gcctgagttg cttggcatat ggattttctt gaatttgctt tcagggtata 3331201 attcagtttt ttcttctttc atatgcagga atgcatcttg agatttgact tcaggaagca 3331261 ccgcaaagtt gtaatgcggc ggaatcgcag aagaagtcgc ccaatcaagc gtacgtccca 3331321 caccccatga atctccgctg atttcacgag tagagtaacg gaagctgtag tagatgttat 3331381 agcaaaggat taagaatcct acacccatca tgaaagctcc gactgttgag ataaagttca 3331441 atgttgtcca gccgtcattc ggtccgtatg tgtaaatacg gcgcggcatg ccttgaagcc 3331501 ccaagaaata ttgcgggaag aaacaaatat tgaacccgat cataaagatc cagaagaacc 3331561 attttccgat tctttcgttc agcttgtggc cgaacatttt tggataccag aaaataaatc 3331621 cggcgaaaca agcaaataca gtacccgcaa tcagcacata gtggaagtga gatacaagga 3331681 agtacgtatt atggtattga taatccgctg ctgccatcgc aagcataacc cctgtaaccc 3331741 cgccgataac gaagttagga atgaacgcaa gcgcccacag cataggtgtt gtaaagctga 3331801 ttcggccttt atacattgta aagagccagt taaagatttt aaccccggtt gggattgaga 3331861 ttgccattgt cgtaattgag aagaatgagt taacggacgc actgttcccc attgtgaaga 3331921 agtggtgagt ccaaactaag aaactcaata cagagatggc gataatagaa ccaaccatcg 3331981 ctttgtaacc aaacaattgt tttcttgcaa agcttgagat gatttctgag aaaataccaa 3332041 acgccggaag aataacgata tatacttcag gatgtcccca aatccagaac aagttagccc 3332101 aaagcatcgg cataccgcct gcttccaatg tgaaaaagtg agcgccgaac aaacgatcaa 3332161 atgataaaag tgctaatgct actgtaagta cagggaacgc aaacacgata ataaccattg 3332221 tgatcagtgt tgtccatgtg aacatcggca tacgcattaa tgtcatgcct tttgttctca 3332281 tttttaagat tgttaccata aagttgatcc ctgtcatcag ggtaccgata ccggcaatct 3332341 gaagtccgag gaggtagtag ttctcacccg gcccagggct catgtcgtta cttgcaagcg 3332401 gcatataact cgtccagcct gcgttcggag aacctccgat aacgaaagaa atattgaaaa 3332461 gcatcgcccc tacaaagaac gtccagaagc tcaggttgtt caagtaaggg aacgcaacgt 3332521 cgcgggcacc gatttgaaga ggcacaacaa cgttgataag accgattaag aacggcatcg 3332581 ccatgaagat gatcatgatt gtaccgtgag ttgtaaaaat ttcattatag tggtttgagt 3332641 ctaaaaaact gttattcgga agcgctagct gggcacgcat catcagaccg tcgacaccgc 3332701 cacggaataa cataattaca gcagatataa tatacatgat tccgagtttt ttatggtcaa 3332761 cagtagttat ccattcagac cacagccatt tccacttttt gaagtaagtc agaacaaaaa 3332821 taatggcaat ggttgaaagc gcaatggaaa cttgtgcgcc cagaattaat gggtcaccag 3332881 ttacgaaaaa ttcgtcccat ttgaatttca tgcaggcttc ctcctttcct gatcaatatc 3332941 attcttctgt atcatcagac ttcttaaatt cgtttttctt tacgttttca aacggatctg 3333001 ttttagaatg cggtgaaacg gcttgatagc caaggcgttt gcgcgcctcc atcgcgtact 3333061 cagcgtcttg tccgtgatca acgtatttca agtgagtaga agagaacgtt aattcgtcca 3333121 cattttcagg aagcatcaat tcatcatact tctcttttgt cagcttagga gcctcgttct 3333181 gagtcttttt cacccagctg ttaaagtctt tttctgtgac tgcattcaca tcaaactctt 3333241 ggtctgcaaa atgttcacct gtgaagttcg cgttgcggcc ttcgtaagta cccactttgt 3333301 cagcctgtaa gtattgatcc atcagcattc ctgccatcgc atatttttgc cctccaagct 3333361 gaggaatcca tagcgaagcc attgaatctg cagatgagat tttgaacaag atcgggcggt 3333421 cgacaggaat gtttaagtag ttgaccgttt caatatcctg ttcagggtag ctaaataccc 3333481 atttccagtc taccgaagta gcataaacaa caagaggctc tttgtctttt gttgcttcag 3333541 gagctttttc taacgaatat atcgtctgta ctgttggcac agaaagtgca atgacgatta 3333601 aaattgggat cactgtccag actacttcta aaaacgtgtt accgtgaatt tctgggttat 3333661 aagatccatt atctttgcct ttacggtcgc ggtattttac taaaataatg gtaaatagaa 3333721 caaagacgac cccgacgata aacagcataa atccgataga taacaggatt aaatcacttt 3333781 gctgttcagc tacaggtcct ttcggatcta gtactgaagc attgctgcat cccccaagga 3333841 cgaaaaccac agttaacagc gctaatacaa gcaacggttt taatgctctg aacaagaaga 3333901 tcaccatcct tcctattgat gtaataaatc tgaagtgcat acttcctcaa aatcttttct 3333961 ctactttgtt atgctatcaa aaacttcact tattagcttt atttttttat aaacttcatc 3334021 ccattttcgc ttaaatgtca taaaatcgac aaaaattgct ccaactttat tcacatctat 3334081 cgcttaagat gaaaagtttc tagttatttc cgcatataaa gtaaagaaag atgatgaaga 3334141 actaattctg acaaattaag gtttaccaca ataaaaaact taggtcaatc aaaaatttca 3334201 ttttgttaaa ctttctagat aggaattatt ttttcctcgt ctagcatctt ttcacacggt 3334261 taccatttta acgcatcaaa tattgaaaga aaaggcgcaa tgaagagcca atatgctctg 3334321 aattgtccgt atttttttat gagagcatcc agttgtttat cttatacaaa aaagaggaat 3334381 gatataagca aataaataaa aaataggatg tgttgcatga tgagttttct tatttcactt 3334441 atcgtcgcta ttattatcgg atggcttgga agcctgtttg taaaaggaga tatgcccgga 3334501 ggaattatcg ggtctatgat cgcaggtctt ataggcgcct ggatcggaca cgggctgctt 3334561 ggaacatggg ggccgcacct agccggattt gccattattc cagcggtaat cggcgcagcc 3334621 attgttgtct ttctagtaag cctgttaacc agaaaaagag gataaaagca gcagcacccg 3334681 aagcgtcagc gctttgggtg tttgttttgc cataaaaatc gaaaaagcct caaccctagc 3334741 ggttgaggct tttgactggt ttggcgccca actgatcgat gaaccttctg aaggcctgtt 3334801 ttccctctgc tgtctgctta aatacaccgg cgtgttcaag gatgcgcgcg aatacatgtc 3334861 ccagctcttc ttttatgact agatctacgt tctcttttgt tatggttctt ttttccatcg 3334921 tccgaagagc ccactcacta tgctttgcag tgagcggatt ttgttctaag gctgttttcg 3334981 gatcagcaga acatagcgcc gctgccgttt ctttcatttc ctcctgtaag cggccaggca 3335041 atatcgccaa tcccatgacc tcaatcaggc cgatattttc ttttttaata tggtggactt 3335101 cttgatgagg atgaaatatt cctaatggat gctcctcatc cgtccggttg ttcctcagta 3335161 cgatatcgag ttcgtacaag tctcccctgc gccgcgcaat cggtgtgacc gtattatggg 3335221 gcgtatcgcc tgtataggcg gcaatgccgg ctttttcatc ggaatacgtc tgccacgtgc 3335281 ggaagatatg gtcagcagct tcggcgacat gacccggttc gtctccttgg agcctgagca 3335341 cagacatcgg ccacttcact aagcccagcg acacgccggg ataatcattt aattcataaa 3335401 cgtcttccgc ttctgcacgt gccattggaa aatcatgcgc gccgccttgg aaatgatcat 3335461 ggcttaggat gctgccgccg acaatcggca gatccgcgtt tgaaccgata aaataatgcg 3335521 gatattggcc aagaaatgac agcagccttt caaatgtttt tttgctgatc tccatcggtt 3335581 catgttcacc ttttaagaca atgcagtgct ccggataata gacatatggc gagaattgca 3335641 ggaaccattg ttcgtcctca aggatgaccg gaatgattct gtgattttgc cgggctggat 3335701 gattcacgct tccctcgaag ccgacatttt ctttacacag caaacacatc ggataatttg 3335761 tctgttcctg ctcttttgca gccgcaatcg ctttcgggtc cttttcaggc tttgataggt 3335821 taatggtcat ttccagctcg ccatattcgg tcggcaccgt ccaatgaaca tttttggcga 3335881 ttctgtcagt ccgtatataa tagacatcct ctgaatattg atagaattcc tttgtcgcct 3335941 gttttgggcc gtataatgct tttgtctctt caaatttgcg aatgacctcg gacggggcag 3336001 gcacaaaaca gcccatcagc tttgcgctga gcaggtcacg gtacgtatct gtatccgctt 3336061 ccattcggcc ggtttcggca gcccatttat agatgggagc tagcaagtcc ggcaggcttt 3336121 gtgactgctt gatgctggtg ctggagttcg gctcgggatg tgtgatgccc agcgcttcat 3336181 aaagacggtt tctcgtatat tcccgatccc agatcgaaat caattttcgt tccaggccat 3336241 actcaagcag ctgttccaga tgttcaataa tactcatatg tcactccccc tttagttctc 3336301 tcgctccctc tccgatatcc gcgacataaa agtccgctcg gagccctgtt ttttcttgat 3336361 atctgtctcc aaccttctga ataaaatcat caacgaactc atcttttaca atgctgatgg 3336421 tgcagccgcc aaagcctgct cccgtcattc ttgatccaat tacaccttcg tgatcccatg 3336481 ccgcaaacac aagctcatca agttcagggc atgttacttc atagtcatcc ttcaatgaaa 3336541 ggtgggattc cttcattaac tgcccgattt catctatatt gttctctttg aacatatggg 3336601 ccgtcttaat agcacgatga ttttcgtata cagcgtgctt tgcccggcgt ctgttcgttt 3336661 cattttggat caggctggaa tgcgcatcga aatcagaagg cttgatgtcg cccagtgcgg 3336721 caatatcgag gccttttttc agatcaagca atgcatcatt gcattcttgg cgtctcgtat 3336781 tatagctgga gtcagccaat gtcctttttt tgttcgtgtt cgcgatgacc agcgcgaggc 3336841 ctgagacatt gagtttgcta tattcatagt caagcgtgtc acagttcagc agcatcgcat 3336901 gatgtttttt ccccattcca attgcaaatt ggtccataat tccgcaattg acgccgataa 3336961 aatggttttc cgcatgctgc gccattttca caagctcaag cgcatctact tcaggatgaa 3337021 aataactttg gagcacgacc cccatcagca gttcaataga agcggaagac gacagtcccg 3337081 ccccgtttgg aatattccct gaaaatacaa tgtcaaagcc atggggaact gcatatcccc 3337141 tctgttgaaa ttcataaatc acgccttttg ggtagttcgc ccagtcgtct tctttttgat 3337201 agcgaatgtc gtcaaggctg cattccttga tgcctgcgtt tctaaagtta tctgaataca 3337261 tccggacaag cccgtcgttt ctttctgcaa cagcagcata tgtacccatt gtcagcgcgc 3337321 acggaaagac atgcccgccg ttatagtctg tatgttctcc aatcagattc actcttccag 3337381 gtgcgaaaaa aaaccgtaac ccctcttttt ctccgaatac acttgcaaat atccccttta 3337441 gctcttcccg catgtgcaat cacctttctg gtttttattt tttattcccc ttatttcttc 3337501 atagaaaacg gcagatcata tgctgcagtc ctctcatacc ccttcttctt ttgttttttt 3337561 aaagacgagc catttgctcg caacatagtt gacgacaaca atgaccgcgt tgtcgagtat 3337621 tttggccaag gtttcatttg tattgaactg gccgacaaga atgatcatca tgcctaaatc 3337681 tatgccgaga gacaggaccc gaacgctgaa aaaagcagtg agctctttca gcaggctctg 3337741 cagatcatgt gttttttgct gaaacacata taatttattt gttatgtaag caaacagcac 3337801 ggacaaaatc caagcggcaa cagtggcggc tttgtaatcc acattcatga tctctaccaa 3337861 tatataaaag ctggcgatat tcacaatggt tgtgaaaacc cccataatga tatacataat 3337921 tatttctcta tacttcactg atgttcctcg ctttctgaaa aacttttcaa aattcttggc 3337981 ctctcgtgct ctctgtctaa agtaaaaaat accgagagtg cgtctaaaaa gctgcggaag 3338041 gtggctggct ggcccaatac atatgattgt ttgatgattc cgtcgaggac tgcacatatt 3338101 attttagccg tatattcagg atcaatacag gcgtcaatca gctttctctc cttcagccac 3338161 ttaatatata acacattttc ttccacccac aattcgtaca gccggacata ggccttgcat 3338221 ttctttaaga ctttatatgt cggcatgttc atggcaaacg aggtgatgtc ccacgacggc 3338281 ttatttatgt aataggaata aagcagttct gcagcgtgtt ttgcagcctc gtccaatgtc 3338341 agcgatttca ctgactcccg ctccatttga tcaagatacc ctataatgat cttttttttc 3338401 atctgacgtt tttcgagaag gtacagcaga aaatcgtcct tgctgacaaa atgaacataa 3338461 aatgctcctt tgctgtaccc ggcggctctg ctgatatctt ctacagaaac cggatcatac 3338521 gctcggtcaa tcaacaaatt cacgccagcg tctataaaac tttcaaatgt tgcttctctt 3338581 ttaatttgaa atttgttttt tttcatattt ttctcctggc ggtaatgatt acccttatct 3338641 tacaccggat caatctttag cggtatttat ttctttaaac ggttatgcta ttcggtttcc 3338701 caggggtcat ttttaatagg ctaaatgatt tattttcatt tacatactat ccagtcagta 3338761 tttaattgtt tattattata aataaggtcc attggttata ttagtcattt ttttagggaa 3338821 taggtaggtg gtttttcctt cagtttgtga acaccgagca actatgtgtg aaatttgttg 3338881 tactcgcctc catcatcgcg ctggcttgtc ttttattgcc cgcatgttgc aggaaaacat 3338941 tttatacaat tggaggttac tatgaaaact catgttaaaa aagatttgga caaaggttgg 3339001 catatgttaa ttcaagaagc tagatccatt ggattaggca ttcatgatgt gaggcagttt 3339061 ttagaatctg agacagcatc aagaaagaaa aaccacaaaa aaaccgtccg gcaagactag 3339121 tccgaacagg cggatctatt tacctctggc ttttctatca cctgatctga gttttcacca 3339181 tatcctctat tcaaaagcaa atcgctgcgc tgagcttgag gacaaacggt gtgtcagcta 3339241 actacgacag acagccggtg atgcgatcac ctcttggcac atgcattgtc ataaagaggt 3339301 gatgcgaaca tgataaccgt gctctggtaa acagcagctt tgctgagaac aagctgcatt 3339361 cggtgaggtt ttgaaagcaa actcgtttat acacggccga gcttgaaaac cttcgcctgt 3339421 ctttagacca ctgtgttcac ctcttcacga cttccttctt ttttcatcct ccagctattg 3339481 tacaacgcat aaatcggact ttcagtacat acctattggt gtaccttttt gcttacgttt 3339541 agcgaataaa aggaggaaag ccatgtacaa agctgattat aaacagattg ctgcaacgcc 3339601 gtcttttcaa gcttttttaa agcagaaacg cgcttttatt gttccttctg cgattttctt 3339661 ttttgttttt tatttttcac tccctgtttt gacatcttat ttcacctttt tgaatgcacc 3339721 ggccattgga gctgtttcat gggcttggct gttcgccatc gcccaattcg ctatgacctg 3339781 gatactgagt actgtgtatt cccggagagc cgcccatttc gataagtatg taagcgcttt 3339841 aaaagaggat ctgaagggtg aacagacatg aatatgactg cttttttatt atttttggcg 3339901 attgttggcc tgacgcttat tatcacgtat tttgccgcga agcggacgaa aacgacgagt 3339961 gagttttata cggcgggcgg cgggctcacc ggcgttcaga atggactggc aattgccggt 3340021 gactacatgt ctgccgcctc gtttctcggg attgccggaa tgattgcgtt atatggattt 3340081 gatggcttct tttacagcat cggttttctg gtggcttatc tcgttgtctt gtacatcgtg 3340141 gcggagccgc ttcggaatct tggaaagtac acgatggcag acatgattgc cgctcgcttt 3340201 aaagaaaaga aaatccgcgg tgtcgcggct ctcaatacca ttgccatctc tactttttat 3340261 atgatcgccc agctcgtggg ggcgggcgcg ctgatcaaac tgcttctagg gctggattat 3340321 accgcggctg tcctcatcgt cggagtgctg atgaccattt atgtcgtgtt tggcggcatg 3340381 atcgcgacaa gctgggttca aattattaaa gctgttttgc tgatggccgg cacactcgtg 3340441 atttcgatta tcgtgttttc gaaattcggc tttagcctta ataccatgtt tgaacagatg 3340501 aaaacggcta ctccgcttgg cgctgatttt ttgaaccccg gaaataaata caaggtgccg 3340561 cttgagacct tgtcgttaaa cttggcactc gtgctgggaa ccgccgggct tccgcatata 3340621 ttgatccggt tttataccgt taaggatgcc aagacggccc gtacatccgt tgtgtcagcg 3340681 acatggatta tcggtgtgtt ttacattatg acggtatttc tcggctttgg tgccgcggca 3340741 tttgtcggtt ttgacgcgat tacggcggct gatcaagcgg gaaatatggc ggctccgctt 3340801 ttagcaaaag cgctcggagg agactttctg ttcgcgtttg tatcagccat cgcctttgcc 3340861 accattttgg ctgtcgtgac agggttggtg ctgtctgccg cctcagcatt tgcccatgat 3340921 atttacagcc agatcatcag aaagggagaa gcaactgaaa aagaacaaat gaaagcggcc 3340981 agatgggctt ctgtcgccgt gtcagtgctc tcgattctcc ttgcgatttt tgcacaatcc 3341041 ttaaatgtgg cgttccttgt tgcactcgcg tttgcggtag ccgccagcgc aaaccttccg 3341101 ctgattgtgt ttacagtctt ctggaaacga ttcaatgcct caggcgcttt atggggcagc 3341161 ctgacaggcc tgatcagcgc gcttgtgctg gtatcgatga gccctagtgt gtgggacccg 3341221 gccggaggtg ctatttttac cggtgatccg ctcattccgc tatctaatcc aggaattatt 3341281 tccatcccgc tcggctttct cggcgcgtgg ctcggaacgg tgctgtcgtc tgataaaaca 3341341 attgatgaag atacgtttgc agaaattcag gtgaaggcgc atactggcgt ccatatggaa 3341401 caggaataaa aaaagctctc tttatcgaga gctttttcct tactttttct tctgctcgtc 3341461 agaaatcgct ttttcaaata catccttgcc ggcagcaccc ggaattacag tgtcaccgat 3341521 aataaaggtt ggaacggctg tgatgtcagc ctcttcatag gcgtgcttca aggcttggcg 3341581 ctgcacgtcc tgatatgttc ttgtttccag tgctgatttg aatgatgcac cgtctaatcc 3341641 cacttcctcg gcgagcttcg tcaagatgtc aatatcgccg atattttggt cctcctggaa 3341701 aaatgcctga aagacacggg tgttgtattc atgtccttta ttgtattcct tcgcaaaatg 3341761 gaagccttca aacgcgaggt ctgtatacgg atggggcgag acgtttggaa aattgatctc 3341821 gactcctaat ttctccgcca ttggctgaat tgatgtctgc cacatgtact gtttagaagg 3341881 atcattgacc ggatcaagct gaggagatgg gcttgggcgc agttcaaacg gcatccactc 3341941 gacttcaaca tcctttcctt ttatcgcttc ttcaaaagcg gcttttccaa caaaacaaaa 3342001 tgggcagacg taatctgaat aaactttaat gtgtactgtc atgataatct cctttcatac 3342061 taaattgatt ttaaactgta acaattaaag ttacaactgt tttttaataa agaagccgat 3342121 ttaggcttct ttcagattga tgacaaaatc ctaaaaagtt ttaggatttt gtcatccttt 3342181 cagcgtgatt gaaaaccctt gaagtctagg aaagccgagc attggagcgg agcgaatgct 3342241 ctaattcgtg agcaccaacg cacaggcttg acaacgaatg cgagggtttg tcgacacgct 3342301 gaaagaagcc tgtaaaggct tcttttatga ttccagcaaa cgctgggcaa tatattctcc 3342361 ttttttgcag ccgcctgggc atgcgtataa agcagaaccg attgtttgtg tatattcgtt 3342421 taacgcatcc tttgctgaaa gagccttcag catcgggata aactgattgt cgggattttt 3342481 ttgaaaactg ataaacagga gacctgcatc catatagccg gttttcggat caagtccttc 3342541 tgtgtaagag aaagctcttc gcaaaatttg tttcccagta gatttcgcta gactgacgtg 3342601 tgaattagac ggaatttgat tcagcttcac gggatctgtt tcctttttct gcccaaaagg 3342661 cgcccccgag ctttttctgc ggccgaaggt atcctcttgg tccttgaggg aagagcggtc 3342721 ccatacctca aggaacattt tgattttccg aaaagccata taggtgccgc ccgtcatcca 3342781 gtcaggctca ccagactgaa tccacacgat cgagttcatc aacgtgtcat ccttcgtgct 3342841 ctggttgcct gttccatctt taaacccgaa gaggttgcgc ggtgtttcac cattttttcc 3342901 accgcttaaa aagcctttgt tcacaaaacg gacctcacaa gtgccgaccg cttgatttag 3342961 caggttacgc agcgcgtgaa acgccacttg ctcgtcgtct gcacacactt gaatgcagat 3343021 gtccccgcct ccctgctttt catccaggtt gtcattgggc atcgctggaa gagcggctag 3343081 gtgcttcggt tttttgcttt tcagtccgaa gcggtccttt ccgtcttttt caaaaaagcc 3343141 aggcccgaat ccgaatgtga ccgttaagtt ggaaggggat aaatcagcag actcacctgt 3343201 atcctgcggc ggcagatact gatttctctg ctccgctgac attttcttgc cagacgtcag 3343261 catctgtgtg agacttgtcc agtttctaaa taacgtaatg atgtcgcttt tgtcttttgc 3343321 tgttacatcc agtgcagcaa aatagacata cgtctgatgg gcagttgtga ttccggcctg 3343381 atgctttccg taaaacggaa caatctgctc ctcctctttt tcatcctttt tcgatggctt 3343441 agccgcagtc tgaacaagcg gagcgagacc gccgagaccg ctggcaccga tcgcaacggc 3343501 tgcccccgcc atcgctcccc attttaaaat gtcccgtctg tgaatttgtt ctggcttttt 3343561 ctgttcatcg ctcatgatgt tacaaaactc cttttatagc acattcgcaa tcttcgacat 3343621 ggtttcagaa agagtcgtca gcttagtgct cagctctctg atttgctttt cacttaattt 3343681 atcataagac gtataggact gatcatttgt tttgtatttt gccattaaaa cttcaaattc 3343741 gctgaactcc gtatccagtt tttccgtcaa gtcggagtga tcttttacaa gcgcgctttt 3343801 cactgtttga taaacggctt cggagccttc cacatttgcc ataaggtcaa ctaaatcaat 3343861 tcgtgagtag cgctcttctt ctcccgtgat tttcgaaatt ccggcttcgt tcagaagctc 3343921 catcgcgcct gcaacaattt gttcaggtgt taatttcagt gattgaattg aaccgtcaag 3343981 ctcttttaca tccttgagaa gctggtcagc tgttgccttt tccccggaaa tatcttgatc 3344041 cttccaaatg gccttctcaa gcttatggaa gcctgtccat ttgtctcctt cttcaacatc 3344101 gttttctcgt gcgtcaattt tcggatcaag atctccgagg ctttcagcga tcggttcgat 3344161 tcgctcgtaa taaacacgcg ctttcgcata taacgttttg gacttttcga tatcgccgga 3344221 tttcacagca cccgtaaatg cttcagtcgc tttgacaagc tggtcactct gctctttgac 3344281 atagccttta tactcatccg ctgcttttgc cagctgatcg ctagcctttt tgccgctctt 3344341 cttcgcttct gtcaggtctt ctaaggatgc tttcaatgac tcggattctg tcttgatttt 3344401 tcctgcatcc ggtttgtctt tttgcgcttc tgtgtagatt ggctgaagat gcttttcgat 3344461 ttctgtatat tcgaatggat agtcgctgcg aatatcgttt tcaaaggaaa gccagtagct 3344521 gtttaactct ttccccttct tttcaatctc tttttggtct cctttttcca ctgagtcatt 3344581 cagcttagaa atgatggttt ccattttatt tacggatgcg gtgatttctt tagtgacccc 3344641 gcttttttca gatgaagctt tttctttggt tgaagatgtg tcattggctc cgcagcctgc 3344701 gcacagcgca aggatgcatc cggctgatac agcgattttt gtgaaattca ttttgtcagt 3344761 tcctttccgt ttgtaaaatg ttttgccgct tctgaaacaa gcgcaatcag taaaaagagt 3344821 aaaatcaaca tttgcggaat cgtgctgtac acagacggat aaattcctag caccgataca 3344881 gacggcagcc agctttctgc atcagacgga agaatgcccg ccagttgaag gctgtgaacg 3344941 ccggttccga gaaatttcac gcacatatac aggacaaccg ccattgatag aagaaaaaac 3345001 ggcttcaatg gaatgcgcat tccgagcttg atcatcagaa caccgacgat gacgagaacg 3345061 ataagccctg cggcagttcc gccgatcagt tcagtgagcg ggagcttccc gacaagcccg 3345121 atgaaaaaga tgaccgtttc gagaccttct cttacaactg ccagaaatgc aatgagcgca 3345181 aaggaaagca ggcttcgttt ttttagtgcc tgtgacttct ggatattgat tttttctctc 3345241 catttatcca ttgaggcgtt tctgtgcagc cacaccccga catacaaaag catgacagcg 3345301 gacagtacgc cggtaacgcc gccaagcaag aaattgtttt ctccgaatac actggaggag 3345361 aacagaaccg tgacaccgat gccggctgct aaggaaacag ccatgccggc ggacgccccg 3345421 ccccagatcc atgtcgagga acgcgtaacc cgcgcttttt ttgtcatggt taatagcgct 3345481 ccgatgacaa ggagggcctc cattccttca cgaaccggga tcagcgccgc atcccaccag 3345541 ctgtagctgc ttgaagcgat cggctcgagc aattgaatca tttcgtcaat ttgctttgat 3345601 accttttcag gatggctgcc gatctccgcc ttcatcagcg ccagattttc ctccgatgtc 3345661 gtataggctt ctttcgattg ggacacgaca tctccctcaa cagcgagcca ggatgtaact 3345721 aaattgtcga ttgcggatga cgcttcatcc aattgttttt tttctatgaa ctgttttgtg 3345781 tctttcaagc tttgtatata ggctgttaag gacgcccttg attgacctga ggatgtcttt 3345841 ttcagcacga cagcctgctg ataggtttct aaatgagacg caagctcttc aagctgtgtt 3345901 ttgagcttac gtgcgtcttg attgataaaa gaaagagaaa tcatcgcgat attcgcgtcc 3345961 atttcactgt gagaagaaag gttttctttc ttaatagaag gttcttcttt tttccacttc 3346021 gccttgaagg tgtcaaacgt ttgttgtgcc gaatccatat ccccgtcttt tacggatttg 3346081 atcatttgct tgtttaattg aattaatgcg gcgatcggat catcttccgc atgtgccgca 3346141 gaaccgaaaa ccatcaacaa gctgaataga ataagtgcca gcccccgagc catcatgttc 3346201 ctcctataat tgaaaatgat tatcattgta taacataatc atagccagtt cctgtccttt 3346261 gtcaattaaa atttgaaggt ctgaaaacct tgatggacag caaaaaagct gtccttttac 3346321 agaacagccc tttgaaggaa aatgaacgat tatcttcctg ttttatacgt ttgaatttcc 3346381 tcacgaaact tgcgtgcagc actctcagga tcctccgcct gactgatggc gctgatcata 3346441 ctgacgccat cggcccccgc ttggataaca ggtgcggcat tatctattgt gattccgccg 3346501 atgccgacaa ttggaatgct gatgccttgg cggcgcactg cttcgataag agatacaccc 3346561 tgtaccgctc tcgtatcttt tttcgtttca gtcggataga tcggcccaag cccgacataa 3346621 tccgctccgt cttcttcggc ttgcttcacc tcagacatcg tatgggcaga aacgccgaga 3346681 atcatatcac ctatggcagc tcttacctct ttcgcatttg cgtcttcctg gccgatgtgg 3346741 ataccatcag ctttcagatt cagagccaat tccacatcat cattgacaat gaacggaaca 3346801 ccagcttcac ggcaagctgc ctgcgctttt tcagcaaatt taatccgagc ctctcctgtc 3346861 agcgcatccc cgcctttttc acggaactgg tacagggtgg caccgccttt taacgctttt 3346921 tgtacaactg taacaggatc ggctttcgta ttgtttgacc ccataatgaa gtatacagat 3346981 aataactctt tcatcatttc ccgagaaata cgagtcatga gacagtcacc ctttctatag 3347041 tcgcccattc ttggacgtct tgttcagtaa cagttgaaag cttgttcagc aattcaatct 3347101 gaaagcttcc agggcctttg tcagccgtct gctgtgcggc aagctgagcg gcgaccccat 3347161 acgaagaaat ggccgcaata gcagcaaaca atggattttc ttccacagcg caaaacgcac 3347221 cgacgacgga agtcagcagg caaccggcgc ctgtcacttt tgtcagcagc ttgtggccgt 3347281 tatgaagggt gtatacatgt gacgtgtcgg ctatgacatc aacttcacca gttatcgcaa 3347341 tgaccgtgtt tagcttttgt gccgcctgct gagccagccg gatgatgtcg cctccacctt 3347401 cacccgcatc aacacctttg atcagccaat cggtcacgcc gacggtatgg gcaatttccg 3347461 ccgcatttcc tctgattgca gcaaggcgca cctcacgaat gatgtcacgt gccgattcag 3347521 tgcggaacgg tgttgctccg gcaccgacag gatcaagaat gacgggaacg ccatgttcat 3347581 tagctgattt tcccgcgatg atcatcgctt cgactgactc cttgctcagt gttccgatat 3347641 ttaaaacgag tgcacccgca attttcgcca tatcggcgac ctcttctttt gcgtacgcca 3347701 taacgggcga tgcgccgagc gcgagcaggc cgtttgctgt gaaattcgtt acgacattgt 3347761 tggttatgct atgcaccagt gggctatgcc ggcggacagc cgtaagacat tttgctgctg 3347821 attgtgcatc catatttgca tcatccttta ctatcttttt tcgggtccca taaatacgat 3347881 ttcgtatgtt cgagccaagc tctggcggca aacgacaagt acctgtcctt tctccaaata 3347941 atggcgaggt gccaagggat gaccggatcg acaagcggaa tgactttcac tttttccggg 3348001 tcaaggccgc ggcagatccg ttccggcaaa agcccgatcc caaggttggc ggataccatc 3348061 tcactaataa aatcccattg tgatgtttca taaatgatat ggggccggaa cccagccttg 3348121 atacattccg tcataattcg gttgtgcagg acaaaatcct ctctgaagaa aataaaaggc 3348181 tcgtccttca actcacgcag ctgacattct ttctcatcag ccagccggtg ggaagggtga 3348241 acgacaagca ttaaggtttc ttttacgatt gtaaacgaat gaaagatatc ttcgtttgcg 3348301 ggaaggacca caacgccgat atcaagagag ccgtccccga caccttcttg gacttttata 3348361 gaaccgtctt cgactagctg aaaggtgaca ttcggatagt tttcacggaa atcgccgagc 3348421 actctgggga aaaaccccga tccgatcatc ggcggcagtc caatccgtac gtgccctttc 3348481 ttgacttcca taatatcatt taattctgac gtcaggtttt gaaatgattt aatgatttcc 3348541 tgcgcctgca catacatgct atgaccggca tcagtcagtt ccacctgcct gccgtttcgg 3348601 taaaacagtt caattccgag ctcttcttct aaatttttga tcatttttga tatcgtcggc 3348661 tgagaaacat aaagggattg ggaagccttc gtaaaacttt ttaaacgggc gacttccaag 3348721 aaatatgtta aatggcggat atccatgcgc ttcacccttt ctatagacaa aaggaatact 3348781 tcttattctt aatatatatt ttacctatag agagacctta tgtacaataa gtatataagg 3348841 gaggcatcaa tatgaaaaaa ctgttgctaa ccgttattca aatcgctctg ttatttatat 3348901 ttgctcggct gattaattgg gtgacagccc ttcttcatat aaatattccc ggcagtataa 3348961 tagggattgt gattcttttc acattattgc actttaacat tatcaagctt gaatggatcg 3349021 agcttggtgc agcgtggctt ctcggggagc tgcttttatt ttttatcccg tctgccgtcg 3349081 gagtgattga atacggagac attatgtcga aatttggtgt cagcattctg cttgttgtca 3349141 tcatcagcac gtttgtcgtg atggtgtcta caggaacgct tacacaactc atcgcaaaga 3349201 gaaaggagaa aaagcatacg tgttcatcgg aattgtaagt ttgtttttaa cggttttggt 3349261 gtatttagga gcaaaaaagg tatatcaacg ctttccgcgt gtttatacgt cgccgctatt 3349321 ggtgacgccc gctgtattag tcggtctgct gctgctggtg aatgtcccgt acgagtccta 3349381 taatctcggc ggcggattgc tgaccgatat gctacagccg gccaccgtgg cattcgcgat 3349441 cccgttatat aaatatttcc ctgttttaaa gaaatacgca gtggaaatta ttttgaatgt 3349501 ggccgtcggt tcatgcatcg cgattatttc taccgctctt attgcgaaat ggcttcacct 3349561 cggcaccggc ttaattgaca gcctcgtccc aagatcagtg acaacgccga tcgcgatgaa 3349621 cgtatctgaa atgatcggcg gtatgcctgc cgtcacagcc gtgtttgtga ttttaaccgc 3349681 tttgctcggc acagtgatcg gcccgatggt catccgttat ttccgcattg ataacgaaat 3349741 tgcgcggggc gtgctgcttg gcacaagcgc gcacggagcg ggaacgtcaa aggcatttga 3349801 gctcagctct gtgtccggca cgatttccag cgtgtcgatg atcttagctg cgattatgac 3349861 gctttgcgcg gcgccgtttt tgctttcatt tatgtaaaaa actgtcctct cgagggcagt 3349921 tttttttatg tgcttcccct tattgaaaag ctggcgaatt ccaatataat gtatttgtgg 3349981 ataccaaagg aggcaccctg atgcacaact tgcaggtgag gcggcattat gccgcgttaa 3350041 aaggatttta tttgtttgct tttctcggta cgggcagcat aattccctta ctcagtatgt 3350101 atttaacgaa ggaacagcat ttaagcggat cacaggtcgg cttgatcatg tcactgggcc 3350161 cgattgtgat gattttcttt cagccgtttt ggggcatgct gagcgactat acgcaaaaaa 3350221 cgaaaggcct gctggcggtt tgcacatcaa tcacaggcat cattggatta gcctatattg 3350281 catttgacag tttccctctg tttattttga ttgcggcctg ttttgcagcc tttcaaagca 3350341 cgattattcc actttcggac agcatttcac taaggtacac acaagaaaca aacggcaact 3350401 acggcggaat ccgcctgttt ggttctctcg gcttcggtgt cgcggtgttt gccatgggac 3350461 aggtgacgaa ccagctgtac cccattcacg tgatctttat ctttggctgt gcctttctgt 3350521 gcattgctgc catattggct tcacaagtgc ccggccagca gaaaacaaca aaggtcaata 3350581 tccgcaaagg attccgggag cttatcagca acaaaacttt cctcatcttt atgatcatca 3350641 cctttacgac atttgctcca aacttagcga acaatacgta tttcagtctt tttctggaca 3350701 aaagcggcgc gtcactttcc gctatcggca ttttattttt catcggtgtc atttcagaaa 3350761 ttccatttat gagattcgcc caaacattta tagataaaat ggggctgctc aacgtcatta 3350821 tgctgtcagg cggagtctca ttattcaggt gggcgctcta tttcacggcg ccttcactat 3350881 ggatcattta tgcgacggtc tttcttcagg gagtggccat cggtttattt atcccggcgg 3350941 cgcttcaata tgtgaaaaag attaccccaa gacacgttga agcgacggcg ctgaccatgt 3351001 acgccgccat tggcaacggg ttcggcaact ggttctgcac atttgcaggc gggtacattt 3351061 ttgactacgt gtcgatcttc gcagtctact tgctttttgg cattctgagc atagcaggct 3351121 ttggcctgac attatattta atgaaggctg aaaaaaacaa acatacactt catcagccgg 3351181 ctgttacttt taaaccataa tgactataat gaacaaaaga aaggatgtgc gttatgaacg 3351241 ggcaagagcg aaacagcatt tcgaaagggt tgcaggttga tattgtattg aaagcagatc 3351301 aaaaaacagg aaaactgacg agagggacag tgaaggatat tttgacgaaa tcaaactttc 3351361 atccgcatgg cattaaagtc cgtcttgaag atggccgcat cggccgcgac cagcagatcg 3351421 tttctacata aaaaaaagct gcccctgaac agggcagctt tttcattatt ttttctgcag 3351481 aaggaccact ttcaggtagt tgccttccgg aaatgccgaa atcgttttga aatcctccgg 3351541 cagcgtaaat tcctcaatga tcgtgtagcg ttcatttgtt tctttaaagg cggcatcaat 3351601 aaagcctttg aacttcttca tgccaaaggc gctgctgttt gtagaggcaa caatgacacc 3351661 cttgtcagca gtgatggcga tcgtttcctt cagcaggttt ttataatcct tggccgcgct 3351721 gaaggtgcgt ttttttgtgc gcgcaaagga aggcggatct agaataatca gatcaaagcg 3351781 caaatccttt tttgcagcat atgaaaaata gttaaaaacg tccatcactt taatgtcgtg 3351841 cgcttcgtaa tccagcttgt tcacgctgaa ttgctcgatc gttttggcaa gacttcgatt 3351901 tgccacgtcg acgcttgttg ttttctccgc tccgccaagc gccgccgcca cggagaatgc 3351961 acccgtataa gaaaacgtat ttaaaacggt tttccctttt gcatagcggt ctctgatcgc 3352021 cttgcgcaca tgtctctgat ccaaaaagat gcccgtcatg gcgccttcat tcagatccac 3352081 cgcgtattga atgccattct cttggatgat gatcgggaac tcgccccttc tccctttcac 3352141 gaagtcatca tcttcaacgt attgtccagc cgtgtcgaag cgtttcttct cgtaaatcgc 3352201 tttataatca agatccatct catccaatgc ggaaatcagc atgtctttaa aggtgtaaat 3352261 tcccttgctg taccattgaa tcagcaggta gccgtcataa tagtcgatgg tgacgccgcc 3352321 gacaccgtca ccctcaccgt tgaacaggcg gaaagctgtt gtatcttgag cctcaaatag 3352381 tttggcgcgc gcttgggccg cttttgttaa tttgctgaga aaaaatgctt ggtcaatctg 3352441 ttcatgttta ttgcgggtaa gcgtccagcc aacccctttg ttttgcaggc cgtaatagcc 3352501 ccgcgcgaga aactcgccgc cgctctcaga cacgatatca acgaggtctc cttctttcat 3352561 gtgccccgca ctccctgcga gagcttcttt ttcaataagg ggatagcctt tttttatttt 3352621 ggcagcgtgt gcttttttta gggtgagtag cttcatatat gtcgtcctct ttccgtttgc 3352681 tttctcttat ggtaccacaa aacgccaaga tgtctgcatt gacagaaagg aaaggttttt 3352741 ctacgataga caaaaagagt tacgaggagg agcagcatgg caaaacgaat tgaccataca 3352801 ggcatcatgg taagagatat taacgcgtcc atcacatttt atgaagaggt actaggcatg 3352861 aaattgaagg atcgcatcac tcacacgaac ggtgtaatcg agcttgcttt tcttggcttt 3352921 gaagacggcc cggaaacaga aattgaactg attcaaggct acagcagcga gcttcccgct 3352981 gaaggaaaag tgcaccacat tgccctgctg acggatgaca tcgcggctga atatacaaaa 3353041 gcggaaaaaa tgaacgcaaa atttatcgac gaggagatca caacacttcc aaacggatac 3353101 cgttatttct atatcgaagg ccctgacggt gagtggattg agttctttca gcggtaaaaa 3353161 taaagaacgt acattttgtg atgtacgttc ttttttatct ataccaactg atatacgttg 3353221 actcatcgca aatcatagct tcccagccca tacgctcaac caattcatgg atgtttttat 3353281 ctttggctaa aaagacatta atgaatgagt catatacact cataaacaca aaatccattt 3353341 tctcatcagt taaaacgagc tctgttgcgg cttcatcaag aaccgtccgc aagttggctt 3353401 cagttatgtc caaaacgccg cggttttcca caatcggttc tgcgtaataa aaccgattgg 3353461 atccgttcgc acctaatacc tttaccaaac tcggaatatg aaaatttgaa atatgatcct 3353521 cactgggata atagaggtct ccatttatgt tttcatgtaa cacctcagcc aaatcctctc 3353581 tcgcgaactc gtcccttaaa gcgcctatcg acgtcattaa agccagcgcc agctcagcat 3353641 gtgtttgaaa gccgcaagaa gacataacct tcttccagga aacagccttg cctattcctc 3353701 ttatttcatt atcgtttgga taaatatgtt cataatcatt ttttcttttt gcattctccc 3353761 atccttcagg catttggata aaaggagaaa agataagagc agcagatgag tattcaactg 3353821 gtacttgttg taagattggt gattcgtcat ctaaccatat ataatctagc atgcgcacct 3353881 cctttacata ttctaacatt cctttcgttt gaaagagatg atcagcccta tgacaggctg 3353941 atcatctatc acatcacatt tttatcccca gattcaaccg cactctcttc ccgccatttt 3354001 tgatgatccc atattctgaa aaacggatag tagatagcac aggtgatcag cagatttacc 3354061 agctgcataa ctgcgcccga cacctttccg cctgtcgcca ggtaacctga tatgagcggc 3354121 ggcatcgtcc atggcaccgc gattccggcc ggtcttgcca ccagcccggt gctcatgccg 3354181 atataagtcg cggtaatcgt gaggagcggt gcgatgataa atgggacaat aaggagggga 3354241 ttcatgacaa tcggcatgcc gaaaatgatc ggctcgttga tattaaatag cgcagggccg 3354301 attcctaatc gtccaagctg cttcatttgt ttgctgcggg agcgcacaag catcgtcagg 3354361 acaagcgcca gcgtcgcccc gcttccgccg acattgatcc aaatttgaaa aaactgagtc 3354421 gtaaaaatac tcggcagcgc ctcgcctgct tggaaggcga gacggttggc atccatcgcg 3354481 ccgtaccaaa tcggcgccat gattccgcca atgatggaag ccccgtgaat cccgcacgac 3354541 caaagcagca tctgcacaaa ttcagcgatc aggcttccgc cgagactgcc gccaaggatg 3354601 gaaagcggtg tgccaagcag gtctcctacg acattgtgca gactctgaaa aggtgtcatt 3354661 tcaatcagaa gacgcgccag ccatacgaga agcacaatga taaagccggg aatcagcgcg 3354721 acaaatgatt tgcttaccgc aggcggcaca ccgtctggca ttttgaagac gatatttttt 3354781 tgaataatgt accgatagat ttcggttgaa aacaaggcga tcagcatggc gacaaataag 3354841 cccttgctgc cgagcagcgt gatcgggatt ccgcccccta ccatgatgga ctccgttgag 3354901 ccatgcggtg taaacggcac ctcaaacggt gttgccagca gaaatgcggc aattgaaatc 3354961 gctccggcag aaagggcatc gacaccatag ctttctgcca gccgataggc gatcccaaaa 3355021 gcggcaatca tcgccataat atcaaacgaa gcgttaacag gatatccgag cttatcggcc 3355081 cactcgttcc caaacacact cgccatgaaa tcagcatacc ccggaatcgg caagctcgtt 3355141 aaaatcaaga agacagaccc gataataatc agcggcatgg tcaggataat tccgtcacgc 3355201 aaagcgctga gatgccgctg cccggcaatt ttcccggcga caggcattat tttttcctcc 3355261 atcacccgag tgaatgtgct catcttaaaa accccctttt ctcattgctt tgtgaacaac 3355321 ctccgcaatg ttttctttat cttattttga aaacgcttac aaattcattt ggaaaatttc 3355381 ctcttcatgc ggaaaaaatc tgcattttgc taaacaaccc tgcccatgaa aaattttttc 3355441 cttcttacta ttaatctctc tttttttctc cgatatatat atcaaacatc atagaaaaag 3355501 gagatgaatc atgaaaaaca tgtcttgcaa acttgttgta tcagtcactc tgtttttcag 3355561 ttttctcacc ataggccctc tcgctcatgc gcaaaacagc agcgagaaag aggttattgt 3355621 ggtttataaa aacaaggccg gaaaggaaac catcctggac agtgatgctg atgttgaaca 3355681 gcagtataag catcttcccg cggtagcggt cacagcagac caggagacag taaaagaatt 3355741 aaagcaggat cctgatattt tgtatgtaga aaacaacgta tcatttaccg cagcagacag 3355801 cacggatttc aaagtgctgt cagacggcac tgacacctct gacaactttg agcaatggaa 3355861 ccttgagccc attcaggtga aacaggcttg gaaggcagga ctgacaggaa aaaatatcaa 3355921 aattgccgtc attgacagcg ggatctcccc ccacgatgac ctgtcgattg ccggcgggta 3355981 ttcagctgtc agttatacct cttcttacaa agatgataac ggccacggaa cacatgtcgc 3356041 agggattatc ggagccaagc ataacggcta cggaattgac ggcatcgcac cggaagcaca 3356101 aatatacgcg gttaaagcgc ttgatcagaa cggctcgggg gatcttcaaa gtcttctcca 3356161 aggaattgac tggtcgatcg caaacaggat ggacatcgtc aatatgagcc ttggcacgac 3356221 gtcagacagc aaaatccttc atgacgccgt gaacaaagca tatgaacaag gtgttctgct 3356281 tgttgccgca agcggtaacg acggaaacgg caagccagtg aattatccgg cggcatacag 3356341 cagtgtcgtt gcggtttcag caacaaacga aaagaatcag cttgcctcct tttcaacaac 3356401 tggagatgaa gttgaatttt cagcaccggg gacaaacatc acaagcactt acttaaacca 3356461 gtattatgca acgggaagcg gaacatccca agcgacaccg cacgccgctg ccatgtttgc 3356521 cttgttaaaa cagcgtgatc ctgccgagac aaacgtccag cttcgcgagg aaatgcggaa 3356581 aaacatcgtt gatcttggta ccgcaggccg cgatcagcaa tttggctacg gcttaatcca 3356641 gtataaagca caggcaacag attcagcgta cgcggcagca gagcaagcgg tgaaaaaagc 3356701 ggaacaaaca aaagcacaaa tcgatatcaa caaagcgcga gaactcatca gccagctgcc 3356761 gaactccgac gccaaaactg ccctgcacaa aagactggat aaagtacagt catacagaaa 3356821 tgtaaaagat gcgaaagaca aagtcgcaaa ggcagaaaaa tataaaacac agcaaaccgt 3356881 tgacacagca caaactgcca tcaacaagct gccaaacgga acagacaaaa agaaccttca 3356941 aaaacgctta gaccaagtaa aacgatacat cgcgtcaaag caagcgaaag acaaagttgc 3357001 gaaagcggaa aaaagcaaaa agaaaacaga tgtggacagc gcacaatcag caattggcaa 3357061 gctgcctgca agttcagaaa aaacgtccct gcagaaacgc cttaacaaag tgaagagcac 3357121 caatttgaag acggcacagc aatccgtatc tgcggctgaa aagaaatcaa ctgatgcaaa 3357181 tgcggcaaaa gcacaatcag ccgtcaatca gcttcaagca ggcaaggaca aaacggcatt 3357241 gcaaaaacgg ttagacaaag tgaagaaaaa ggtggcggcg gctgaagcaa aaaaagtgga 3357301 aactgcaaag gcaaaagtga agaaagcgga aaaagacaaa acaaagaaat caaagacatc 3357361 cgctcagtct gcagtgaatc aattaaaagc atccaatgaa aaaacaaagc tgcaaaaacg 3357421 gctgaacgcc gtcaaaccga aaaagtaacc aaaaaccttt aagatttgca ttccaagtct 3357481 taaaggtttt tttcattcta agaacaccac acacaacctt tttcccatcc attgtacagg 3357541 cttttcatac tattgctata cagccatgaa cagcataaaa tgaacgttat tacagttatc 3357601 accacatatg gcgggattgt gactgggcag gcaggcaaga cccaatgatg caaagggagt 3357661 attaatgcct aaaaaacagg gcattttaac tcttcttttc gtgttgggct cataacggcg 3357721 ccttggacaa ccccctattc tcatgctccg tcgtcgacgc gggcattttt gtcattttca 3357781 gccggtattt ctcacttttt tcattttgat tgtcaacttt tcatttgata cgatgaacaa 3357841 gccgactttt cttcagcaaa ggaggtttta attgcttgca taaagagatt gcaaaagaat 3357901 tactgctgct cgcaggagga aaaaacaata ttatcagcat cagccattgt acgacccgtc 3357961 ttcgttttga tgtaaaggac gagacgaaaa ttgatataca tgccattgag aacctgcaag 3358021 gtgtgcaggg cacctttttc cgctatgggc ttttccagat tatcttcgga gcaggcgtcg 3358081 tcaacaaaat atataaagaa gtcgttcatg tatgggagac cgcgccttct gaagagcctg 3358141 tccaccagaa aaaagccagc cggaagctga accctgccgc agcttttgcg aaaacactgt 3358201 ccgatatttt tgtgccgatt attccggcaa taacagcaag cggcctgctc atggggctga 3358261 tcggcatgat taaggtgttt cattggttcg ctgccggcag cccatggatt aaaatgctcg 3358321 acctcgtgtc cagcacagcc tttattttac tgccgatttt agtcggcttc agtgctgcac 3358381 ggcaatttgg cagcaaccca tacctagggg cagtgattgc agggcttttg acgcatcctg 3358441 atctgctgga cccgtctatg ctcggcagca aaaccccgtc ttctttagac atatgggggc 3358501 ttcatatccc aatgatgggc tatcagggtt ccatgatacc gattcttctt tccgtttttg 3358561 tcatgagcaa aattgagaag ctattaaaat cgattgtgcc gaagtcgctt gatgtcgtga 3358621 tcattccctt tattacggtc atggtgacag ggtgcctcgc gctgattgtg atgaatcccg 3358681 ccgcgtccat catcggccag atcatgacac aatcgatcgt ctatatttat gatcacgccg 3358741 gcattgctgc cggagctctt ttcggcggca tctactccac catcgtccta tctggattgc 3358801 atcatagctt ttatgcaatt gaggcaacgc tgcttgctaa tccgcatgtc ggtgtcaact 3358861 ttttagtgcc gatatggtcg atggcgaatg tggcccaagg cggagcgggg cttgcggtat 3358921 tcctcaaaac gaaacaatca agcctgaaga aaattgcgct ccccgcttct ctgaccgcgt 3358981 ttttaggcat tgttgagccg attgtattcg gggtaaatct caaattgatc cgtcccttta 3359041 tcggagcagc catcggcggt gctattggcg gagcatacgt ggttgcggta caagttgtgg 3359101 caaattccta cggactgaca ggcattccga tgatttcaat cgtgctgccg tttggcgccg 3359161 ctaattttgt tcattatatg atcggtttct tgatcgcagc cgtctctgct tttatagcta 3359221 cattgtttct cgggtttaaa gaagagacag aataactgga tttattcgat ttcattcata 3359281 aaacggggga tgaaaggaca aaaaagctat gaaaattaaa agaatcttaa atcataatgc 3359341 tatcgtcgta aaggatcaaa atgaagagaa gattctcttg ggtgcaggaa ttgcgtttaa 3359401 caaaaagaag aatgatattg tcgatccgtc aaaaatagaa aaaaccttta tcagaaaaga 3359461 tacacctgac tataagcagt tcgaagagat tttagaaaca ttgcctgaag accacattca 3359521 gatttctgag caaattatct ctcatgccga aaaagagctg aacatcaaaa tcaacgagcg 3359581 cattcatgtc gctttttcag accatctttc ttttgcaatt gaacgcctga gcaatgggat 3359641 ggttatcaaa aatccgctgc tgaatgaaat caaagtcctt tatccaaagg agttccagat 3359701 cggcttatgg gccagagcac tgattaaaga taaactgggg attcacattc ctgatgatga 3359761 aatcggcaat atcgccatgc atatccacac agcaagaaac aatgccggcg atatgacaca 3359821 aacgcttgat attacaacaa tgatccgtga tattatcgag attatcgaaa ttcaactgtc 3359881 tattaatatc gttgaagata ccatctctta tgaaaggctc gtgacccatc tccgctttgc 3359941 cattcagcat atcaaagcag gcgaatccat ttacgagctg gacgcagaaa tgattgacat 3360001 cattaaagag aagtttaagg atgccttcct gtgtgcccta agcatcggca cctttgtgaa 3360061 gaaggaatac ggctttgagt ttcctgaaaa agaattgtgc tacatcgcca tgcatattca 3360121 gcggttctac caacggtcag tcgcacgctg agacaaacaa aaaacgcttt tgatcatctc 3360181 aaaagcgttt ttttatctga tttattggtt gatcgccgga ttcccaatcg tattccactt 3360241 cgtataggac atgtaatgga aatactcatc gcgatacgga tgttttgtat tggagttcca 3360301 aggcttttct ccgccgcaga agtgcacgat tgccgggttt tctcttgttt cattatattg 3360361 cttccgccct aacagagtcg atggggtttt cagctttaac atgatatagg tttgagcgtt 3360421 ccagcgcgga tgaagttcat accactgatc atacaagatc gcattcagtg catcttggtc 3360481 atgcagcaca agaaagtctt cgtctgggtg ttcattgata aagttgatga ctttttctgt 3360541 gatgttttgc tttctccaag actcaaaatc aataatcatg atacctgagt taaaatactt 3360601 ccctgtatca gtgacgttca tttctttcag gcgttcatgc tgccccgcat cctcaacagc 3360661 ggctacggtg tatggcgcaa tgtctaagtc ccatagctta gaaatatcct ctaggacaag 3360721 cgcatcacaa tcgatgtaaa tcattcgttt gatgctttca tccttaatta agtcgggaat 3360781 cgaaatgcgg taatacgcgg cttttgtaat atggctgctc tcaaccgcat gttcatacat 3360841 gttggtatcc acttctaaaa actcaatcgg cactccgaat ttcaaagtgg tttcttccag 3360901 tctttttttg ttatcaggct taattccgcc atcaatgacg tataatttta cctctctctc 3360961 ctgatccatg ttagtcaata aagaaacgaa catcccacct aaatgacgag cataattatc 3361021 atctgcgcat gatacgatat gcatgatttc atctttcctc aatggtattc atctcccttt 3361081 ttgttgtaca agttacatac cctttttcaa aaaaataaac acgttctccg acattttttt 3361141 aaacagaatg tgtgatacaa caaaaaaggt gtcatttttt gaagatgcga taaagccaat 3361201 aaagaatgaa aaagcttgcg attgtgatgg cttcagccga gacgatatac cacggccatg 3361261 gcccgagaac atctaagaga gaggaaccgc ccggtttttt cgtcaaatac atataattcg 3361321 cgccaagcca gcgatcaatc agaaaaatac agacgccgta cacattaaca agcaggactg 3361381 tcacccataa cgagcgctgg cccattctgt aggtgccaat cacagccatc agcagacagg 3361441 ataaaaacac agacccgtga gaaataaaaa agaggatata tcggatatgc ggaaatgaaa 3361501 acataccgag gtcaggagtg gcaagagcct gaatcgaact gccgatgccg acaaaaaaca 3361561 aaaacacaaa cagctttctg ctttttgtca ctaacataat agctgacaaa tacaccgaca 3361621 ggtcactaag ctggagaggc aatgaagtgc gcaccgacca cctgtccgtg gcgaccatcc 3361681 atatttgata gccgatttgc gaaccaagca aaagaaacac aaacagagaa cgcaaaaacc 3361741 ggctggccct cggctgcttg acctcatctt ggaacaaaaa caacagaatg gccaaaaggg 3361801 agataatcgc taacgtcact acatgctctg tcgaaaacag atgaaacgga tcatgcttat 3361861 agtcggattg aacatatttt tgcaaaactg cacccccgtt ttcgggtttt tgtttatttt 3361921 ggcgttgttt gggctttttt tattcaaccg atatatgggc ttgaagttca caccagactc 3361981 tgttaaaatt cgtttcatag ctaatgattc tgataattta aggcaggcct aaaaaatgga 3362041 acgttcacat caacatcagc agcttcggaa ggaagaacac gatacacttt ctaagctcaa 3362101 acaaatgccc gtcgagtcac tcaacctgga agccatttcg atcgctacga atctgtatcg 3362161 gtctgcacaa aggctccgtg tcaaaatgga gactgaggtt ctttctacct ataacctttc 3362221 ttggaccgct ttctccattc tttatgatct atgggtatgg ggagcgctcg aaacgagaaa 3362281 aatcgctgag ctgtcaggga tatctacagc tacagcaagc aacgtgatca aaacgctcga 3362341 aaaaaagagt ttttgccgta aaagcatcga cacaagagat cggcgactcg tgtttgtctc 3362401 aatcaccgat tccggcaaac aagcgatcga agaactctac ccggagtttc acaaagggga 3362461 aacagagctc attgcgggaa tgacgaagga cgaacagaaa atattgacag ggctgcttag 3362521 aaaggtagct gacaatcttc atacaacata agctttgacg ggaatccagt agcggtttgt 3362581 ctccctgttt cagagagccg gcggtaggtg cgagccggcg cacaggcaaa cgtgaattac 3362641 ctccccaagc tttctttgtg aaccttagta gcaaagaacg ggaaaccgtt attcgaatga 3362701 gcggaagaca atgtcttcaa ccagggtggt accgcgtgca ttgagccacg tcccttattg 3362761 ggatgggctc ttttttgtgt ttgtaaaaaa ggaggaaaaa tgatgagaac atttgagcag 3362821 ctcacagcgt cacaacaaaa agaggtagaa agacagcttc agctatacat gacaggcgcc 3362881 cacgaagtca taccgccgga ggaattaaag gcaaagctcg tgaaatcaat ttccacgggc 3362941 acgccgctta aaattaagct cggattagat ccgtctgcac cggatgtaca tttgggccat 3363001 acggttgtgt taaataagct tcgccaattt caagaaaacg gccacattgt ccagctgtta 3363061 attggggatt tcacaggaaa aattggtgat ccgaccggaa aatcggcagc cagaaagcaa 3363121 ctgactgatg aagaagttca gcacaatgcc aaaacctact ttgagcaatt cggaaaagtg 3363181 cttgatccag aaaaagtcga gcttcactat aactcaaaat ggctgaaaac attgaatcta 3363241 gaagatgtca ttgaattagc agggaaaata acggtagccc gcctgatgga gcgcgacgac 3363301 tttgaagaac gcatcgccat gcaaaaacca atctcactgc atgaattctt ttacccattg 3363361 atgcagggct atgattctgt cgttctcgaa agtgatattg aattaggcgg aacggatcag 3363421 catttcaatg tcctcatggg acggcatttc caagaacgat acaacaaaga aaaacaagtc 3363481 gtcatcctta tgccgctctt ggaaggcttg gatggcgtcg agaaaatgtc gaagtcgaaa 3363541 cacaactaca ttggcattaa cgaacatcca aacgacatgt acggaaaaac gatgtcactg 3363601 cccgacagcc tgatgaaaaa gtacatccac ttggcgacag acttagagct tgaagagaaa 3363661 aaacagctcg taaaagactt agaaaccggc gccgttcatc cgcgtgatgc caaaatgctt 3363721 ttagccagaa caatcgtccg aatgtatcac ggagagaaag cagcagaagc tgccgaacac 3363781 tcgtttaaaa cagtctttca ggaaaacagc ctgccggaag atataccggc cgtaaactgg 3363841 aaaggcgaaa aaacgatagc gatgattgat ctgctcgtca agctaaagct cctctcttcg 3363901 aagagcgagg cgcgccgcat gattcaaaac ggaggtgtac gcatcgacgg agagaaagta 3363961 acagatgttc acgccaaagc agagataaga gagaatatga tcatccaagt cggcaaacgc 3364021 aagtttttaa agctccaata atctgatatt ccgaaacgct tatgaccctt cattcataag 3364081 cgtttttttg caggtataaa gcactgtctt ttcaaaaacg ctctccatct tgcaggaaac 3364141 tcctttagca tcccgaaata ttccccaacc atacatttag gggaggttta tttttgatga 3364201 aaaagctttt gactgtcatg acgatggctg ttttaactgc cggcacactg ctcttgccgg 3364261 cacagagtgt cacccctgcc gcgcacgctg tacaaatatc aaatagcgag cgcgagcttc 3364321 cattcaaagc aaaacatgcg tactctacca tttctcagct aagtgaagca atcggcccca 3364381 gaatagccgg aactgcagct gaaaaaaaga gtgccctatt gatcgcctca tcaatgagaa 3364441 aattaaagct tgatgtgaag gttcaacgat tcaacattcc tgaccggctt gagggtacac 3364501 tgtcttcagc aggacgcgat attcttctcc aagcggcgtc gggctcagct ccgactgagg 3364561 aacaagggct gacggccccg ctttacaatg cgggattggg ctatcaaaag gactttaccg 3364621 ctgacgccaa gggcaaaatc gccttgattt ccagaggaga cctgacttat tacgagaaag 3364681 ccaaaaatgc cgaagccgcc ggagcgaaag ctgtcatcat ttataacaac aaagaaagcc 3364741 tcgtgcctat gacgccaaac ctgtcgggaa ataaagtcgg cattccggtc gtcggcatta 3364801 agaaagaaga cggcgaagca cttacccagc aaaaagaagc caccttaaaa ctaaaagcat 3364861 tcacaaacca aacctcccag aatatcatcg gaatcaaaaa accaaagaac atcaaacatc 3364921 cagacattgt gtacgtgacc gcccattacg acagtgttcc tttttcgccc ggagcaaatg 3364981 acaacggctc aggtacctct gttatgctgg agatggcgcg tgtcttaaaa agcgttccat 3365041 ctgataaaga aatccgcttt atcgctttcg gcgccgaaga gctcggcctg ctcggctcct 3365101 ctcactatgt agatcatcta tcggaaaaag agctgaaacg aagcgaagtg aacttcaact 3365161 tagatatggt aggcacaagc tgggaaaaag cgtctgagct gtatgtcaac acattggatg 3365221 gccaatctaa ctatgtttgg gaatccagcc gtacggctgc tgaaaaaatt gggtttgaca 3365281 gcctgtctct gacacaggga ggatcatctg atcatgtgcc attccacgaa gccggcattg 3365341 attccgctaa ctttatttgg ggagacccgg aaacagaaga agttgagccg tggtatcata 3365401 cccctgaaga ctcgatcgaa catatcagca aagaacgcct ccagcaagca ggcgatcttg 3365461 tgacagccgc tgtctatgag gctgtgaaaa aagagaagaa accgaaaacc attaagaaac 3365521 aaatgaaggc gaaagcatct gacatttttg aagatatcaa ataaaaaaag acggcacttg 3365581 ggtgccgtct tttttaatcc acttctttct taatccccag cattttctca tctaggtaat 3365641 gggcaatctc cgcggcttct ttcagctcat ctgttaattg cttaggaacg tcattgttca 3365701 atttataata aattttatgt tcaaggctcg cccagaaatc catcgcgatt gtccggattt 3365761 gaatttctgc tttgacgtat tccacacggt tcgttaaatt cacaggcatc tcaatgatta 3365821 aatgcaggct tcgatagcca ttcggtttgg gtgtctggat ataatccttt acctttacga 3365881 ttctcaaatc ttcatgctgc ttcaacacat tcacgacatt ataaatgtca gaaataaagg 3365941 aacagatgat gcgcacgccg gcaatgtcgt gaatatgctc cttcatttcc ttcgtcgtaa 3366001 tctcacagcc ctttctcatt aacttattca cgatgctttc aaagcttttt acacgggatt 3366061 ttgtatgttc aatcgggttg tgtccgtgaa tgaggttata ttcctggctg ataattgaga 3366121 actttgtatc gagcgcatct agcgcaaatt tataaactaa taactcattt ttccaatctt 3366181 ccattactgt ttttaaatcg tccatatgtg ttacagataa atccatgttc gtcatctcct 3366241 ttaacggaac tttatccgct gtccatgtac tagacgtccc tgtctgctgc aaggttctat 3366301 gaattttttt acaaaatgcg gtcgattgta acaaaaaaag accgcatgaa acgagcggtc 3366361 ttttttatta tcggaaatag ctgatcaata atccgatcga gagcaggaat ccgaaaaatg 3366421 tatttgtttg ggctgttgat ttcattgcga caatcatatt catcggcatt tcgttctgga 3366481 cgaagccctt cactgcctga accggcttag gcacgctcaa aaagacgaca aacagccatg 3366541 ggcttgcggc accggtaata accaagccga caacccagat ataagcgacg gcaaacgacg 3366601 cagctaacag agtaacagct cccttatgcc ccatcaaaat cgccaatgtt ttgcgtccgc 3366661 cttttttgtc ctcttcaata tcacgaatgt tgttcgacag gttaatcgcg ccgacaagaa 3366721 tcgcaatcgg gatggaaatc aaaatgctct gcatattgat cttatctgtc tgaatgaaaa 3366781 acgaaatcag cacaaacacc gaacccatgc aaatgcctga gaataattca ccgaacggcg 3366841 tgtacgcaat cggcagcggc ccgcctgtat acaggtagcc gatcgccatg ccgacaaggc 3366901 cgatcagcgc aagccaccag ctgctgctgg cacaaatata gacaccgagc aaaatggcaa 3366961 tcccgtatga ggcaagagct aattgcaaaa tcgttttagg cttcattccg tggcgtacaa 3367021 tggcccctcc gattccgact gattctgctg tatctaatcc gcgtttaaaa tcatagtatt 3367081 cattaaataa gttcgtcgcg atctggatcc ataggcaaga aaacagcata gccaaaaaca 3367141 gcagcagatc aaccttcaca taaaacatcg ccaaaacggt tccgagcagc acaggcacaa 3367201 acgatgcggt taacgtatga ggacgggtta actgccaaag gatctgcccc atgctttctt 3367261 tttgcggcgc tgtctgaccc tcacccttat ttgtttggtt catcttcctc ttcctttcta 3367321 ttaaaaggct tacttttttt cagccggcag cttaataaaa aactcctttt gcttccttat 3367381 ctatcataat gacttctccc ttatttcaca agataccgca agaaggcgtt ttctttctta 3367441 ttatacgctt ctcgccctga tttcattagg tttctgcttt cacttgaacg aacaggtaca 3367501 gaaaaatttt tttaagtaca ttacactttt taaaagttaa aaagatcttt tgactccagg 3367561 tatcttttcc tttattatga atcagctcga aacattccat tcttgccctt gcaggtataa 3367621 agattcattt tcaaaaacat acgccgatat attaatttga gggagattag ggaaaaaatg 3367681 aaactttttg agcatctgat cgtcaaataa tcatgtgatt gtcgaaaaaa cgggaaggga 3367741 atttttgata tgctgcaatt aatgaaacag ctgtatgaaa aacccgctgt caagtggaca 3367801 tgtcatacag gcttttattt gatgatactg cttgttttgt tttttatgta tggttttcac 3367861 accgcgaata ccggttcata tatttataac gatttctaat tggagagaga ataactatga 3367921 aacttttaca tgctattcaa acacatgcgg aaacttatcc gcaaaccgat gccttccgct 3367981 ctcaaggcca gtcgctcacg tatcaggaat tatgggagca gtctgaccgc gcggctgccg 3368041 cgatccaaaa acgcatttct ggggaaaaga aatctcctat ccttgtgtac ggccacatgg 3368101 agccgcacat gatcgtttcc ttcttgggaa gtgtcaaagc gggacatcct tatattccgg 3368161 ttgacctgtc tattccgtcc gaacggattg cgaaaattat cgaaagctct ggagcagaat 3368221 tgctgatcca tgcagcagga ctctcaattg atgcagtcgg ccagcagatt cagacagttt 3368281 ctgcggaaga actgctggaa aacgaaggcg gctctgtcag ccaagatcaa tgggtcaaag 3368341 aacacgaaac gttttatatc atttacactt ccgggagcac aggaaatccg aaaggcgtgc 3368401 agatttccgc tgcgaacctt caaagcttca cagactggat ttgtgcagac tttccagtca 3368461 gcggaggaaa aatattttta aaccaagcgc cgttctcatt tgatttgtct gtcatggacc 3368521 tatatccgtg ccttcaatca ggcgggactt tacattgcgt gacaaaggat gctgtgaata 3368581 agccgaaagt cttatttgaa gagctgaaga agtccgggct gaatgtgtgg acatcaacac 3368641 cttcctttgt gcaaatgtgc ctgatggatc cgggtttttc acaggatctg ctgcctcatg 3368701 cggacacatt tatgttttgc ggagaggttc ttccggtttc tgtggccaaa gcgctgcttg 3368761 agcgttttcc gaaagcgaag atttttaata cgtacggccc gactgaagcg acagtggctg 3368821 tcacatcggt tgaaattacg aatgacgtca tcagccgcag cgaatcgctt ccagtgggct 3368881 tcgccaaacc agatatgaac attttcatta tggatgaaga gggacagccg cttcctgagg 3368941 gagaaaaagg agaaatcgtc attgcagggc cgagtgtaag ccgaggctac cttggtgagc 3369001 cagagctgac ggaaaaagcg tttttctctc atgaaggcca gtgggcatac cgaactggcg 3369061 atgccggctt tattcaagac ggtcagattt tctgccaagg acgtttggat tttcagatta 3369121 aacttcacgg ctatcgaatg gagctggagg aaatcgagtt ccatgtcaga cagtcacagt 3369181 acgttcgttc tgctgtcgtg attccttatc agccaaacgg aacagttgag tatctgatcg 3369241 ctgctattgt gcctgaggag catgagttcg agaaggaatt ccagctgaca agcgctatta 3369301 aaaaagagct tgccgcttct cttccggcat atatgatccc gagaaaattt atctatcagg 3369361 atcacattca aatgacggct aacggcaaaa ttgaccgaaa acgcattggc gaagaggttc 3369421 ttgtatgacg ccttacagct cgtttttatt ctttatactg cttggcattc ttcttctgcc 3369481 gacgatcatt ctcggcttaa acggaaaaag atttcaagca tacaacatgt tcatatctat 3369541 cattatattg gctttaattt tttcgcacga cttacacggg gtcatcgcgc tgtgcctgtt 3369601 tacaatatgg caggtgctcc tgatcagcgg ctatctggca taccggcaga aagcgaacag 3369661 cggctttgtc ttttgcggag ctgttatcgc gtctattctg cctttatttc tgtcaaaaat 3369721 atggccgttt ctttcacacc cgcagccgca tcatccgccg cataacctga tcagcttttt 3369781 agggatttca tatttaacct ttaaaggcgt tcagctgatt atggaagcaa gagacggact 3369841 gctgaaagaa cagctgccat tgcaccgtct gctgtatttc atcctgtttt tcccgacgat 3369901 ttcctccggc ccgatcgaca gataccgccg gttcgtcaag gatgaacaga aggcttggac 3369961 gaaagaagaa tacgccgacc tgctgtatac gggaatccat aaaatcttca tcggtttcct 3370021 gtataaattt attatcggct acgcgatcaa tacgtacttc atcatgaatc ttcccgcaat 3370081 cacgcacaat aagattcttg ggaacctgct gtacatgtac ggctacagca tgtatttatt 3370141 ctttgatttc gccggctaca cgatgtttgc cgtcggggtc agctacatta tgggcattaa 3370201 atcaccagaa aactttaata aaccgtttat cagtaaaaat attaaagatt tctggaatcg 3370261 ctggcatatg tctctgtcat tttggttcag agattatgtg tttatgagat tcgtattttg 3370321 gatgactaag aaaaagtgga tcaaaaaccg tatggccgtc tcaaacatcg ggtatttcct 3370381 gctgtttatg ctgatggggg tttggcacgg gctcgcgccg caatatatca tttacggcct 3370441 ctatcacgcc gttctgatga cgtgttacaa ctttttcgag aagtggaata agaaatataa 3370501 atggctgccg tccaaccgct ggacaaccat tctcgctatt gtgatcacat tccatttcgt 3370561 ttgcttcggg ttttatattt tctcaggaaa accatttcat caccaccatt aaaggagatt 3370621 agaaagctat ggattttaaa caagaggtat tagacgtttt agcagaggtt tgccaggatg 3370681 acatcgtaaa ggaaaatcct gatattgaaa tttttgaaga aggtttgctt gattcttttg 3370741 gaacagtaga attgctgctt gcgattgaaa accgttttga tattttagtg ccgatcactg 3370801 aatttgaccg ggacgtttgg aatacaccta acaacattgt aaatcagctg tctgagttga 3370861 aataatgaaa aagcgttttt tcggtccaat tattttggcg tttattctat tcgcaggcgc 3370921 catcgcaatt ccatcttcat ggctgacagg cttcatcacc gataagcgtg tgaaagagtc 3370981 agcaacagcc ttgaatccga gtatgtttca agggctatat ttacaagatc agatgctcaa 3371041 agatccgaca tatcttccga tttacgggtc ttctgagctt tctcggctgg acgagttcca 3371101 cccatctaat tattttcagg taaacaatga gggattcacg ccataccttg tcggcaaagg 3371161 cggatcccag tcattgattc attctttaaa cttcgctgcc cacatggatc agctgaaggg 3371221 caaaaaaatc gtattcatcg tgtctccgca atggtttatt aagcgcgggt ctgatgaaca 3371281 gcatttcgcg ccgaactatt ctgcgctgca agggcttgat ttggcattta acgatcagat 3371341 cgatcctgaa attaaaaaga aaatgatgaa acgcatgctt cgctttaagg ctgtgcaaaa 3371401 cgatgccatt ctttctgagc tgtacaaagc aatggtaaac ggtcagacgt ggaaagtgaa 3371461 cgcgctgaag ccggcggcga aagtgtatta cagcatgctg gaaaagaaag atctgtatta 3371521 ttcaacgaca gaatcatccg ggccaaagcg ctatatctcg cagtcagtaa aggataagtc 3371581 atggtctgaa ttgaataaac tagcggatca atcgggcaaa cgccactccg gttctaacga 3371641 ttttcacatc gacaaccctg tctataaaaa gctgaagccg aaagtgccta agctgaaagg 3371701 gaaaaacaaa ggaagatcgt atgcggtgtc accggaatat ggcgactttg aaatgatgct 3371761 cgatatcctg aaggatgcgg gcgcagagcc tatgtttgtc accattcctg ttaacgggaa 3371821 atggtacgat tacacgggct tcccgaaaaa aggacgcact gactattaca aaaaggtaaa 3371881 taaacaaatc agagcgaagg gcttccaggt tgctgatttc tcagggcatg aatatgaccc 3371941 gtatttcatg aaagacacca ttcacatcgg ctggaaaggc tgggtgtatg tcgataaagc 3372001 aattgacgaa ttttataaaa ccggaaaagt cacttcatcc tgagcatctc ataggacgcg 3372061 gctgcatatt tcctgctaag atttgtaata gtaaaggaat cacagccaac ttaattaaga 3372121 ggtgttacat ccaatgaaga tgacaaataa tacggtttta atcacagggg gttctgctgg 3372181 catcgggctt gaactggcca agcgcctgct ggaacttggc aatgaagtta tcatttgcgg 3372241 acgcagcgaa gcacgtcttg cagaagcgaa gcagcagctc ccaaacatcc atacaaagca 3372301 atgtgatgtt gcagaccgtt cgcagcggga agcattgtat gaatgggctt taaaggaata 3372361 tccgaacttg aatgttctcg tcaacaacgc cggcattcaa aaggaaattg actttaaaaa 3372421 agggacagag gagctttttg tggacggtga tgaaattgaa cttaatttcc aagcgcctgt 3372481 ccatttatcc gcccttttca cacctcattt gatgaagcag cccgaggcgg caatcgttca 3372541 ggtcacatcc gggcttgcgt ttaacccgtt agctgtttat ccggtgtact gcgcaacaaa 3372601 agcggcactt cactcgttct cgcttacgct cagacaccag ctccgcgaca cgagcgtgga 3372661 agtgattgaa atggcaccgc ctatggtgga cacgggctta aaccaaaaat cacgcgataa 3372721 acaaggcctg acgtaccggg gcatttcatc tgaagaatat gttcaatatt tcttggacgg 3372781 cttgaaggaa ggcaaacagg agattacaaa tgaacgtgtt gaaggtcttc gggatgccac 3372841 tcgcgccgat tatgacaggt tattcgagca aatgaacacg caggagaatt aatttctcct 3372901 gcttttttca tatgaatttc ttacaaattt gagcaaacct attgcgatta tttgttgaag 3372961 gtatacaata gaatataatt attttcaaat aagtttgata atataaacaa tttaacagca 3373021 gggagattga ccatgactaa acaaacaatt cgcgttgaat tgacatcaac aaaaaaaccg 3373081 aaaccagacc caaatcagct ttcgttcgga agagtgttta cagaccacat gtttgtaatg 3373141 gactatgccg cagataaagg ttggtacgat ccaagaatca ttccttatca acccttatca 3373201 atggatccgg ctgcaatggt ctatcactac ggccaaaccg tgtttgaagg gttaaaggct 3373261 tacgtgtcag aggatgacca tgttctgctt ttcagaccgg aaaaaaatat ggaacgcctg 3373321 aatcaatcaa acgaccgcct ctgcatcccg caaattgatg aagaacaggt tcttgaaggc 3373381 ttaaagcagc ttgtcgcaat tgataaagac tggattccaa atgcggaggg cacgtccctt 3373441 tacatccgtc cgttcatcat cgcaaccgag cctttccttg gtgttgcggc atctcatacg 3373501 tataagctct tgatcattct ttctccggtc ggctcttatt acaaagaagg cattaagccg 3373561 gtcaaaatcg ctgttgaaag tgaatttgtc cgtgcggtaa aaggcggaac aggaaatgcc 3373621 aaaaccgcag gaaactatgc ttcaagctta aaagcgcagc aggtagccga agagaaagga 3373681 ttttctcaag tactctggct ggacggcatt gagaagaaat acatcgaaga agtcggaagc 3373741 atgaacatct tcttcaaaat caacggtgaa atcgtaacac cgatgctgaa cgggagcatc 3373801 ctggaaggca ttacgcgcaa ttcagtcatc gccttgctta agcattgggg ccttcaagtt 3373861 tcagaacgaa aaattgcgat cgatgaggtc atccaagccc ataaagacgg catcctggaa 3373921 gaagccttcg gaacaggtac agcagctgtt atttccccag tcggcgagct gatctggcag 3373981 gatgaaacac tttcgatcaa caacggtgaa acaggagaaa tcgcaaaaaa actatatgac 3374041 acgattacag gcattcaaaa aggcgctgtc gcagacgaat tcggatggac gaccgaagtc 3374101 gcagcgctga ctgaaagcaa gtaagaaaaa agccggccca ttacaggccg gcttttttta 3374161 cgcttcaatt ttgttgaaaa actgcggcag atacgctttg tgcgcctcta gcatttcgtc 3374221 taaaatctgt ttggccacag tatcggacgg gacaagcggg ttaatcgtca tggcaaggag 3374281 cgcagtttga tagtcacctg taactgccgc ttctgccgcg acacgttcaa aggatttgat 3374341 ttgctggaca aggccgcgga cagacaccgg caagtcgccg acagcaattg gcttagggcc 3374401 ggttttcgtc atcacacagt tcacttcaac tgcggaatcg tctggaatac tcgctattgc 3374461 accattattg atcgtgttca ccggctgaat gtcatgttta tcattataaa tggagctgat 3374521 taagttacat gctgcatcac tgtagtaagc tccgccccgt ttttccagct gcggcggttt 3374581 gatcgcaagg tttggatctt tataaagctc gaacagctct ttttcgacct tctgtacgac 3374641 ttcagcgcgg gtgccctccg tttgtgatgc ttccagttcg tgctccagca tctcttttgt 3374701 tttaaaatag taacggtgat agccgcaagg gatgacattg agcgctttta agaaatccgg 3374761 ttcccattcg gcgcctgaga tatttttcat cgtcatcgcg tttttcgggt cgcccatcgc 3374821 ctcgatgact tgctccttca cacttacgcc gtccaagaaa acatccagcc cgaataccat 3374881 atggttcagt ccggcaaatt ggacttctac gcggtccaca tctacatcaa gcgctttggc 3374941 tacgcccatt ttgatgccga ttggaacatt gcaaagaccg acgactttct tcaggttgga 3375001 gtagcgaagc aaggcttctg ttaccatgcc ggcagggttt gtgaagttaa caagccaagc 3375061 gttcgggcaa agctcttcta tgtcctttgc gatctcaagg atgaccggaa ttgtgcgcaa 3375121 tcctttaaac agacctcccg ggccgtttgt ttcctggcct atcactccgt attttagcgg 3375181 aatgcgctca tcctttgctc ttgcctgcaa aagtccgacg cggaattggg tcgtgacaaa 3375241 gtctgcgtct ttcagcgcct ttctccggtc gagcgtaaga tgaatgtcaa tcgggacgcc 3375301 agctttttca accatccgtt tggcgagtgt gccgacaata ttcagctttt cttcgccctc 3375361 ggggatatcg acaagccata attcacggac aggcagctca tcataccgtt taatgaaccc 3375421 ctccactagc tcgggcgtat agcttgaacc tccgccaatc gttacaatct tcaatccttt 3375481 tgtcatatgc ttgctcccct ttgctcggtg attttttcat ataactcaat gatctctgca 3375541 gccatatcct tcactgtcat tgcattcatt aaatgatcct gtgcatgaac catcagaagc 3375601 gtcatttccg tcttttctcc gcccgcttca ttttggatca gctctgtctg ataatgatgg 3375661 gcttttgaca attcttcagc agcgtcttga agctttttcc gcgcttcttc tgcgtcaccg 3375721 cttttcgcag cggcaatggc ctccattgcg gagctcctac cgtttcctcc gtgaaggatg 3375781 atttgaaaaa tgatttgttc catttcctca ttcacgcgat tcacttcctt tctctacaga 3375841 gccgcttctt tgtcatctgt tgctgcaggc gtttggacca gctccagatc gttttcttct 3375901 ttcagcttct gcttatccca cattctgaag aatggatagt agacaacaaa ggacacggca 3375961 atattaatgg cttgcatgac cgcgcctgag acttttcctc ctgtcgccaa gtagcctgaa 3376021 aagatcggcg gcatggtcca cggcactgcg atacccgccg gtttggcgac aaggccggtg 3376081 ctcattccga tgtacgtgag tgtcactgtg acaagcggcg tgatgataaa cggaagtaag 3376141 agcattgggt tcatgacgat cggcattccg aatataatcg gttcgttaat attgaagatg 3376201 gccgggccga ccgcaagctt cccgagctgc ttcatttgtt tgcttcgggc gcgcaggaac 3376261 atcgtgacaa ccagtgccaa tgtggcgccg cttccgccaa tattgaccca gatatcgaaa 3376321 aattgctggg tgaaaatctt aggaagctcc tcaccggctt ggaatgcgat ccggttggca 3376381 tccattgcgc cgtaccaaat cggtgccatg acgccgccaa caatgtttgc accgtgaagg 3376441 ccgcaggccc ataaaagcat tttgacggct tcggcgacaa ggcttcctcc aaggcttcct 3376501 cccagaatgg aaagcggagt ccccaataaa acgcttacaa tattatgaag gctttcaaac 3376561 ggtgtcgctt caacaatcag ccgggctgcc caaattagga agatgacggc aaagccgggg 3376621 attaacgcga caaatgactt gcttaccgcc ggcgggacac cgtccggcat tttgaagact 3376681 aaattgcgct ggataataag gcggtaaatc tctgtggaca ccattgcgat aatcatggcg 3376741 acaaataagc ctttgcttcc catgagcgaa agcggaatcc cgccgccaac catgatttct 3376801 ttcgtcgcgc catccggcat aaacggcact tgataaggtg ttgctaataa aaatgccgca 3376861 agggaaatgg ctccggccga caaggcatca acaccgtatt tctcggcgag ccggtaggca 3376921 atgccgaacg cggcgacaag acccataatt tcaaaggtcg cgtcgactgg gtaggccagt 3376981 ttttcagacc aggagctgcc aaacgttttt gccataaact cagcgtatcc cgggatcggg 3377041 aggttgccaa tgatgaggaa aaaggaaccg atgataatca ggggcatcgt gaggatgata 3377101 ccatcacgca gcgcctgcaa atgacgctgt cccgcaattc ttcccgctat aggcatgacc 3377161 ttttcttcta agatctgatt gactttattc acatagcccg cccctctcta tgacacatgt 3377221 ccaagctgtt cagctgattt cagcacttcc gccccattgc acgttccata atggacggta 3377281 ttaatgacgt ctaccggaac cccctttgac tctcctaatt ttttgagctg cggaagcatg 3377341 taacggactt gcggaccgag aagcaataca tccgctttat cgatatgatt ttgtacagaa 3377401 tcgcctgaaa ctgcccaaat ggtatagtct tttccctgtt cctgcgcact tttttccatc 3377461 ttgctcacca gtaagctagt agacatgcct gctgcacaaa cgagtaatat attcatgtaa 3377521 aagaccccct agagtttgat caattttgta atgtcctgct gttgctatca tcatattatg 3377581 aaatcgcttt cataaacact cagggttttt ccgcaggcaa cggaaaaaag gtatatacag 3377641 gctgtcagct cagcattttt tggtcaaaca catccgaaag ctcttgatat gaacggcatt 3377701 tgatcagctg gttcatcgcc gccgggtcat ccaaaatgct gccaagcagt ttatacatgc 3377761 tttgtaaatc cgctttgttc tccttttcga cacaaagcag acagacaaat tgaactcgct 3377821 gactctccca atcgatcggt tttttgagcg tacaaacggc ccaaaacgtt gttttcgtct 3377881 gcggaacaag cgggtgcggg atggcaacaa gattgccaaa acacgttggc gacatgtctt 3377941 ctctttcaaa aatggaatct atgatttctt catcggcaaa gccgcattcg accactttct 3378001 gccctaaaaa ttgaatcact tcttcttttg agcgcagatc ctcctgaaaa aaaacgagtt 3378061 ctttttttag gtagcgattg gctttttcct tttcatcact cagaatagat tctatttttg 3378121 taaagtcagt tccgcctaag atggtgttaa ccttcagtac tggtacaggg agctcttttt 3378181 taatcggaat ggtgctgatg acaaaatcaa ttgattcgta ggacatttga tcaagactat 3378241 aatactcagc cgttccaaga atatcgagcc gcttgccgaa atgggaacgc agtttttcgc 3378301 gcagaagctg ggcgcttccg gctcccgatg cgcatacaat gatacagcgt ttcggcgggc 3378361 tttctgtttt ttttcgttca atcgcggcgc caaagtggag agccaaatat ccaatttcgt 3378421 tttcatgaat ctcaataccc gtttgttcct ttatcacgat tccggcaatg atcccggctt 3378481 caaaagcgag tggataatgt tccttgatcg ctgccagcat cggatttcga agattcatgc 3378541 cgtatcggtt gcggctgatc gccggcttca tatgcagtgc caagccgatt ttcagctctt 3378601 tgtcatgcag gatgccaagc ttcagttcac gatcaacagc tttgatcatg gcaagtgtca 3378661 gctgatcggt ttcctcttct attgaaaatg tgtcctctcc gcattgtgat tgtgtcattc 3378721 gttttgtgcc aaggagatgc atggtgatgt aggccgtctc gtctttcgga aacgtaacgg 3378781 aaagctttga ttccagctct tttacgatgg cttctgcagc ctggtactcc ttttgatgca 3378841 ggatatgatc catatctttc gggaaaagag aaacatagtt ttccgttctg atccgtttac 3378901 aggcgatagc gatatggata atgaggttat tcagtcccat gttggacaga gggatgcggt 3378961 cgtttttcat ttttttcaag atggcggaac ggatgatctc aatttcttct tttggcaaaa 3379021 tatcagcctt ttcatttaaa acatctatct ccgtttctct ttcatcaaca atgtactccg 3379081 ccatgcagta cctcatctgc acctcgtccc cgcgcagctt gaagccgtaa ttcggacgtg 3379141 tttccatgac gatgcggtaa ggcagcagac gtttctttac ttcctttaaa tccgtttgga 3379201 gtgtagattt tgagataaat agttcttcag caagttcatc gagcttgaga taatggtccg 3379261 ccagcagcag acgtttcata agataggcca ttctctcctc cggcaatacc ggcaggccct 3379321 ttttttgctg aaattcatct tgcagcagtg ttctgaatac ttgctcgtca tcaatgcgga 3379381 gcttgtagcc ggagcctctt acagattgta caaaggcacc gtggccgctt agcacacctt 3379441 gaagttcctt tatatcattg cggactgtcc gcgtcgttac gtttaattgc gcggcaaaaa 3379501 acgaacttgt caccggggct tcagccgcca tcagcaagcg cagaatatca cgtagtcgcc 3379561 catgaagcat gagaaaaacc tcctaactag tagatgcagg gattcagtga ataggcagaa 3379621 aggatgatga agggatgcga aatgtatata aattctataa tggagagaat ggcaagtcaa 3379681 tgaacatccg gaggactaga gggaaaactg acctataaaa aaacagccgg gatcagccgg 3379741 ctgttctaga tgcggacata ttcttttgtt tagacgcctt gcggtccttc atgatttttc 3379801 gaacaatcgg gtaaatgacc ggcgcccatt tgataacggt tttgatcatc tttttcaaag 3379861 ctccgattct cccttctttt ttctcaacca ttcccctgat tgcctcttcc ttaaacatgc 3379921 taacgcgaca cgtacctgtt tcccgtcacc cagaaacgcc atggataatc gcgtgcctcc 3379981 ccgctgttgt caatgccgat gcgcgggccg gttgaaattg cttccggtgt gtacccgctt 3380041 tcgatgtaaa gcggctgttc cgtgatccag cgtccgtagt cattcatcgt gacgccaagc 3380101 gctttcgtca gctttcctgg tccgtttgtc cattccctcg gactcctgcc cggccttctc 3380161 tcctccatta acagctggcc ttcatgcggc tcaatcgccc tgattaatac tgcttgcggg 3380221 acatcctctt ccgccgcaac gacattcagc aatgtatggg tgtgcatcac gtatgtatat 3380281 acccgcccag cttctgcaaa catgatctca gtccgcttcg tccggcggtt gttaaagctg 3380341 tgggccgctc tgtctccagc ccccatatag gcctctgttt ccacaatata gcctgacgct 3380401 gtgccttcgt ctgtttcttt tacaagaagg cagcccagaa gcgatggggc aagctcaaga 3380461 gcggtttttt gataaaacgt gatgggcagc ggattttttt ctctcgtcac gaatcgacct 3380521 ctccttttac cgatttttgt acattgtacc attcccgaag cagatcaaaa aaaacggctg 3380581 ttttaaaatc tttccattca gggaatattg ttaccgttca aaaaaggagg gccaaccatt 3380641 gaaagatgat catcaaaaca agcagcacca atcaaatgcc caagggagcg aggaagcgtt 3380701 ttctcataag acatccggga aaaacgagtc agaggatacc ttaacgaata ggcaggggca 3380761 tcctgttact gacaaccaga atgtgagaac cgtcgggaat agagggccta caacacttga 3380821 gaactatgat tttctcgaaa agatcagcca cttcgaccgg gaacgcatcc cagagcgggt 3380881 tgttcatgcc aggggagcag gtgcacatgg atattttgaa gcgtacggaa gcttcggaga 3380941 cgaaccgatt tcaacataca caagggccaa gctctttcag gaaaaaggca agaaaacacc 3381001 ggcatttgtc cgtttttcaa ctgtgaatca tggaaaacac tcgcctgaaa cattgagaga 3381061 cccgcgcggt tttgctgtaa agctatatac agaagacgga aactgggatt tggtcggaaa 3381121 caacctgaaa atctttttta tccgcgaccc gctgaaattt ccggatcttg tacacgcatt 3381181 tcagcctgat ccagtgacaa acatccagga tggtgaacgt atcttcgatt tcatttctca 3381241 atctcctgaa gcgacacaca tgatcacctt cttgttttcg ccttggggca ttccggccaa 3381301 ctaccggcaa atgcagggtt caggcgtaca tgcctataaa tgggtgaatg aggagggcaa 3381361 ggccgttctc gtgaaatacc attttgaacc gaagcagggc atccgcaacc tgacacagaa 3381421 ggaagcagaa gagattcaag ggaaaaactt taaccatgcc acacaggatc tatatgacgc 3381481 gattgaaaat ggcgattatc cagagtggga agtatatgct caaatcatga gcgatgatga 3381541 gcatcctgaa ctggactttg atcctcttga tccaacaaaa ctgtggtata aagacgattt 3381601 cccatggaaa ccgatcggca aattggttct gaacaaaaat ccggaaaact accatgcgga 3381661 agtggagcaa gcttcatttg gaacgggagt gcttgtcgac gggcttgatt tttcagacga 3381721 caaattgctc caggggcgta cgtttgccta ctctgatacg cagcgctacc gtgtaggcgc 3381781 aaattacctg cagcttccga tcaactcgcc gaaaaagcat gtcgccacca accaggaagg 3381841 cgggcaaatg caatatcggg tcgatagagc agaaggacaa aacccgcacg tcaactacga 3381901 gccatccatt atgggcgggc tgaaggaagc gaagcaagac ggaaaagacc atacgccgca 3381961 tgtcgaaggt gatgtaaagc gtgaagcgat tgacagaaca aacaacttcg gacaggctgg 3382021 agaaacgtac cggagattta ctgaatttga gcggaacgaa ttgattacga atttggtgaa 3382081 tacgctttct acgtgccgaa aagaaattca ggatcaaatg attgagaatt tcacaaaagc 3382141 tgatcctgac tacggaaaac gcgtagcaga agggctaaaa aaggtctccg aaaacaacag 3382201 caacgggccg atcggcacaa ctgaaacgga acaggctgca aagcaggctg aacaggagag 3382261 tcatccgtct gatccgtatt aacaacagcg aacagggctt ttttagaagc cctgtttttt 3382321 tatttttcta ttgaaacgct ttcaataatt gtgttgtact tggaaggaaa ggggtggaga 3382381 gatacgatgg aattacagca ggacttgatt cctcagaaaa aaacaatcgg cgctttagat 3382441 cacgccgttt ttttatgcat ggtattttgt ttctggtttt caggctatat ttacgttcct 3382501 gtattcagtc tgtatttgga ggatctgcac ttttcatatg gcgcaatcgg catcattctc 3382561 ggcagctacg gggtcacgca aatccttctg cgattcccgc tcggcctttt gtcagacatc 3382621 ctgttttcct tgcgcaagca attgttaatt gccgggttcg gcttttccgt cctcagcagc 3382681 ctgctttttc tgatgtttga ttctttcttc ttcgtgctgg ccgcccggct tttcgcggga 3382741 atcactgctt ctacgtgggt gatggcgacc attttatacg cacattattt caacaatggc 3382801 aatgcatcaa aagcaatggg catcatgcag ttttttaccg tcatgcctca gtttgccagc 3382861 attgtgttct gcgggctcgc cgcagcccat ttagggaggc aggttccttt ttggatggcg 3382921 ctggcagctt ctgccgcagg tctggtgatc tgctgcttta ttcaggatcc gtctgctcct 3382981 cccgcaaacc gtggcaccat tcgtgtcaat cagtacatca aagatacatt gcggctgcca 3383041 aagctgaagc ttttcaccat cctgtctatg acggcccatg ccgtattatt tatcacagtg 3383101 tttggtttta cgccgcttta catgaatcag ctcggaatgg gcgacgcgga gctgctttgg 3383161 gtgatgagcg cctttttcct cccacacgca gccgccacat taagctttgt gtttctgcgc 3383221 tttacaagcc gtatcgctta ctccgtgatg ctcattagtt tcgctgtcac cggggtctgt 3383281 ttgctatatg ttcctttttt agctgcattg ttcacggttt gcatcacaca cgcctgtatt 3383341 gggctggcgc tcggcttcgt ttttcctctg ctgctaagcc atgtcgtcga aatcagttct 3383401 gcccgtttaa aaatgtcagt gatggggttt taccaatcat tttatgcgct aggcatcttc 3383461 ctcgggcccc ttcttgccgg aaaaatcgca cagcttatcg ggcttgcggg agttttttat 3383521 ggagccggtt ctctggcatt tgccgccttt tttgtgatgc tcgcgcaaaa acgtaacatg 3383581 atcaattaat agctttcata ccgccggaag cgccacacag aaaacacggc cagaagcatg 3383641 atgcacagaa tggagaaagt gagtgaccat ccgaaaaaat ctgcccgctc tccatgaaga 3383701 aggatatgct ccgcctgctt gcaaatctca gccggaagcc acttcgcacc atctggaaat 3383761 agtgaaacag caaaggaaac ggctgctgtg agcccgatcc cgcaagccgc agctgctccg 3383821 acagaccgga atatcgtact tccggcaagg ccggcggtca caataaatat cacccaaaga 3383881 gcgtaaaggc caaggcttgc ggcaaagcgg ctgaatgatg cgtcctcaaa cagcagccgg 3383941 acgtaatagt aagcaagccc gtatccagct gcaaacgaca taatgccgat cacgctttgg 3384001 atgagccatt tactcacgat ataatgggct gccgtcacag gccgcgacat aatcagcgct 3384061 gttacccctt gatttctttc attggctaca ctgcccatca cgctaaagat gaccagagcc 3384121 atgccaagcg tgttgaattg agaaagcgtg ctgaccatca cttcagaccc ggagggcatc 3384181 gtaaaactga ttttcatgcc gtcaggaagg ttccctccat gtgcgatgat ttccggcata 3384241 taataaatgg tcagcggctg tgtcagcccg acgatcatca tcgcaatcgg cagccaaatc 3384301 agcttgccgc ttttccatcc ttccagccac tccttctgca atagcgccat catcaccttc 3384361 atgcgtgcac cacctttaga tagacgtctt ctagagactc cgttttctgt tcaaagcggg 3384421 tgacggtcaa tccctttcgg atacagtcac ttaataatga ccggccagcg tgtatatcag 3384481 gcagctcgaa aaccgcttgg gacggattct tatagacaat agctgagacg taaggcttct 3384541 cttcaagcca accttccagc ttctctttca ctgaaagggt aaaaacgttc gtttgctgct 3384601 gttgtttcag ctcctgtaac tcgcctttcc atgaaatctc accgtttttc ataatcacca 3384661 cttgatcaca cacctgttct gcatcgtgca aaacatgtgt agaaaacaga acggccatat 3384721 gctttttcag ctcccgcatc atgtccagca cctcgaaccg tcctgtcgga tcaagcgcag 3384781 acaccggttc atccaatatc aaaaacttcg gtttatggag cagtgcctgt gccagaccga 3384841 gtctttgttt catgcctcct gaatagcccc cgatcctttt gtgcgccgct tcgtgcaaac 3384901 cgacaaattc cagcatctcg ccgattttct cttggcattt tctcttcgaa aggccggaca 3384961 gtctccccgc aaatgtcaaa aattcatttg cggtcatcca cgaataaaaa gcaggatact 3385021 gcgggaggta cccaatcaaa cgccgatcca gctttttctc tcctaacagc tttatggttc 3385081 cagaggttgg cgaaagcagt ccggccagca tttgcagagt cgtggttttg ccggctccat 3385141 taggtcctaa tagtgcgaca cactcatttt cattcacgtg aaaactgaca ttctttacag 3385201 cttcatggtg cctgtacgat ttgcataatg attcaataga cagcatatcg gcttaccttt 3385261 gctttctgcc gacggtgaaa aataaaatcg gcccgataat attgatacat acgatgattg 3385321 cagcccacat ccactttggc ccgttcgtcc gctcttcttt tatacagctg ataagggcaa 3385381 acaccgccaa agccagctgt aatacaatca gcggcaaaat catttcccaa gaaatattca 3385441 ttgcttgatc ccccttttct tccgatccgg cctaatgaca aaaaagtaat aacaaatcag 3385501 aggcatcggt gcttgaatca atccgacaat cccccaaacc catgccatgt gattacgttt 3385561 tttcgcatca ataaataaaa agattccctg cgccaatacg atgagacaag ccgcaaccgt 3385621 tatgataatt tctgtttgtg tcatccgcgt ttcacctcgc attcgccgag atgccttttt 3385681 ttctcagccg caatcaaaat cggcagcacc gcaagcacac aaacctgaag cacaataaac 3385741 acagcaggag cttgagtgaa agctaagatt gcagcactca caaccatcag cgcgcagaat 3385801 acaaataaaa tgatctcttg aagaagtttt tttctgtatt cagctttcat ttgtgacagc 3385861 tggtgaagca gttctttttg attcggtata gagggattgg ctgtttgatc aatttttttc 3385921 cattctgact ttaaatgatc agaaagcttt tctttattca tcatcccact cctttctgat 3385981 ttgctggagc cctttatgaa ctctggactt tacagtgcct tctttgattt gaagcatcac 3386041 cccgatttca gcgtaggtat agccgtagta atgccttaat aaaaccggtg tgcgcagttt 3386101 agggtccagc tttgaaaaca gatcgagcgt ttcgctccac tctgcccctt tcgccgacac 3386161 gtcccacttg atcttgcgga ttgtttcctc cgtaactgtc tgattccgtt tccattctct 3386221 ctttctcttt ttctggtgat cgagatagag ccgcgatgca atggagatca gccatgtgga 3386281 gaattttgaa cggccctgaa agcttcttaa atggatgtac cctttcagaa aggtttcctg 3386341 aacaagttcc tcgctgagat cggggtgaag ggaaagcttt aacaagtatt tatataagaa 3386401 agaatagtga tagtggaaaa gggctgtaaa cgcctcgtcg tttccctctt tcgcctgctg 3386461 gatcagccgc tgttcttctt gtgtatccaa tgaccgtgat cccccctttt ttgtttttct 3386521 gccttatgag acgacaccgg attcaaaagc gttcatcttt tttacaattc ttttcagcca 3386581 ttgacagatc aggcttcccg gccgtttggc tgcatatcct tatttgtaaa cccccttata 3386641 gtctgttaag ctatgacttt atgtcgattt caaaaaaaca tccaatatgg aggacgatgc 3386701 attgaaagta gaaaggcgaa cgattgaata tattccgaat gaagaaagac atggtaaagc 3386761 gaaagattta tttcccgtat ggttcggggc taatatgcat atcaccacgt tagtgaccgg 3386821 cacgattccc gttgcaatgg gacttaatct gttttggagt gttgccgcta ttatttgcgg 3386881 aaccttaatc ggtgccatat ttatggcttc tcattccgcg caaggccctc agctaggcat 3386941 cccgcaaatg attcaaagcc gtgcccaatt cggcgtaatc ggagcgattc ttcccctctt 3387001 cttagtcatg tttatctacc ttggtttctt cgcaagcagc acgattctgg cggccggaac 3387061 cttaagcagc tttgttccca tcccgggatc atggagcatt ataggcttaa gtgccgtatg 3387121 ttttttactc accattttcg gccatgattt gattcacaaa atgcaaaaaa tcctttcttg 3387181 gacctctttt gctgtatttt ttgctgcaac gattctcatt tttcaattgc cgattccggc 3387241 aggcagctgg atacccggag cgattgatct gccaattttc ctagtggcag tcagcgcagt 3387301 tgcgacgtgg cagcttgcct acgcgccgta tgttgccgat tattcaagat atctgccagt 3387361 taaaacaccg gcttcaaaaa cattttggta cagctatgca ggtacatctg tcagctccat 3387421 ctggatgatg ctgctcggcg cattgctgac aacctcactt cctgacttta cggcaaactc 3387481 aggcagccag attgtccaat tgttcggtcc cttctcgttt attatgctga tcattgtgct 3387541 atttgggcaa atggcaatca atgtttttaa cctgtatggg gctttcatgt ccacgacaac 3387601 aacgctggag ccgtttctga aattaaaagt cacgcccaaa gtcagaatca tcatgatcct 3387661 gggtgtcacg cttgtcggca cagtcttaag cctactggga cagagcaatt ttatggaact 3387721 gtttttgaat tttatctttt tcatcagtta tttcttaatt ccgtggacgg caatcaattt 3387781 agtcgattac tacttcgtcc gccacggaaa gtatcaagtc aaagccatgt tcgacgtaaa 3387841 cgggccttat ggaaaggtca attggatcac cacaattgcg ttcgttctgt ctatcttgct 3387901 ggaaattccg tttatcaaca caagctttta catcggaccg cttgccaaaa tgtttggcgg 3387961 cggagacatc gcatggatta tcggcttggc cgtgccttct gtgctttact atgtattaat 3388021 gaaaccgcgt ctgaaaaaac gggcggggta tcaagaaaag ctgtcttctc tctgaagaca 3388081 gcttttttat cattcaaatc gtttccacac gcggggcagg atgtcagata gctcatgagc 3388141 gagcaacgta tgagcggagt gctcgtccgt ccagagctcg gcgcacgcac catgcaaata 3388201 gaccgcgttt aatacggcgt gctttggatc ttcatggcag cagagcatcc ccaatatcat 3388261 gcccgtcagc gtgtcaccgg ttccgccctt ggcgagcgcc ccgtttccgg ttggattgag 3388321 ccagcagtct ccatcaggaa acgcgatgac ggtttggttt ccttttaaca caatgacagt 3388381 ctgcagctga gccgcccatt cctttgcata ttccgctctt tttttctgca attcgttcac 3388441 gggcacccct gtcattcgga aaaactcgcc cgggtgcggc gtgaggatga cggggccctc 3388501 ccgtttcgga tatgtgcgct tcgccagcgc tccggcatcc aaaataacag gacaatcagc 3388561 cgtaagcaca tgatcgactg cctgctgtac gctttccgtt tgcggaaggc ccggtccgat 3388621 ggcaatggcc cggtacgtct cttcaagctg agcatccgcc gcctttttcc agccgtcacg 3388681 ccaataggtc gcctcgggca aaacaggaac aattagcggg attacgtttt ctgatgtacc 3388741 gatgacaagc ttgccgagac cgctccgcat ggccccaagc cctgcaagca gcgctgctcc 3388801 cggcatgtcg tcacttccag ccagcagcaa agccgtaccg tacgtgcctt tatggctctc 3388861 cgcatctctt tcaggaagcg tggcccttac atgctcttcc gtccaaaatg gaacattcat 3388921 ctctatccct cctctgcttt cttttcctat ttttcctgtc ccttttcttt ttcaaacaaa 3388981 aaagacagcc ttttagggct gtcttttatt ttacaggaac atcaaggtga tacaggcggc 3389041 gatatcgttc gtttgccgcc agcagctcct catgggttcc ttccatttct gttttgccgt 3389101 tttcgagaaa tacgatttta tcggctgctt ccactcccgc gagatggtgt gtaatccata 3389161 aaatcgtttt tcctttcagc acctcaaaca ccgtttccat caattcacgt tcggtaatag 3389221 gatcgaggcc gactgttggc tcatcgagga tgatgatcgg tgtatcctgc agcaaaatcc 3389281 tcgcaagtgc gatccgctgg cgctctccac cggaaaaacg gatgccggtt tcttgtacag 3389341 aggtatgata tccgtcaggc aatgactcaa tgtagtcatg cagcttgacc tgctttgcgg 3389401 cgcggcgcac atcctcgtcg cttgcttctc cgtttccgag cctgatgttg ttcaaaatgc 3389461 ttgtatcaaa caggtgcggt ttttgattta acacggccac cgcatccgca atctgatcct 3389521 ttaacagcgc tgtctccact ccgtttaacg tcacagaacc ggagtccggt ttcaaggcgc 3389581 cttcgattaa tgcaagcgat gttgatttcc cagagccgct tcggccgagc agcgccattt 3389641 tttctccttg gcgcagcgta aaggaaaagt tgtgcagcac ttggctgctg ttgtcataag 3389701 aaaacgtcac atcacgaaag gccaaggtga catcttgaag atcgagaatt tgatcccctg 3389761 attcagtttg tgacgcctcc ggctgaggag ccacattgtt catgcgtctg atagaatcct 3389821 gatagcccgg cacttcgcct aaggcatccg aaagcggcaa aaaggcttcc gtcaacggaa 3389881 acaccactag cacaaaagcg gcaatcatcg ttttagcgag ctcgccgtcc gcttgctgtc 3389941 ccgctgtcca aaacagcatc agcaaaataa ggccagcgac aaggcattgc gcagcaaagt 3390001 cccgccatct tgtaaagcgt tgttttttcc gttcaagctc aaaccaatca cgttcctctt 3390061 tttcataagc atcaataaaa gcatgccggc gtccgctgaa catccagtcg ctgacaccca 3390121 tcacagcatc tgtcagacgg ctgtacagca cattccgtcc gcttttcagc ttcgcattct 3390181 tcgctctcgt cacgagcaaa gacacaaccg gaaacaatac aacaagaaca aacaaataca 3390241 gcgcaagcaa tatggcaaac ggccaagaga agaagccgag cgctatcact gacacagcat 3390301 acaggagcaa ggctgagatc gcaggaaaaa tcgtttttaa gaaagcatcc tgcaaatgct 3390361 caatatcctc agacaaaatg ccgagcatat cccccgtgcg aaaacgggaa cgcagcatca 3390421 aagcacccgg ctcaagcata ttgtaaaggc ggacgcgcat gtcagatacg attttcaaaa 3390481 tgatgtgatg gccgacgagc cgttccacat atcgcgacac agagcgcgca atcccaaagg 3390541 tgcgcacagc gacaatcggc acataaatga gcagaatgtt ttccggcctt gtcgccgctt 3390601 tagaaatcaa aaaacctgag gtgaacatga gaaaagcagc agaaaaaatc gtcaccgcac 3390661 ccaaaaagat aaccagaacg aacaggcggg cattttgctt gatatacggc aaaatccatt 3390721 cttctttctt catgctcttt cccccagttg tgccttcacg agtttggtat acacaccgtt 3390781 tttctccagc agttcattgt gagtcccaat ttccgcaacc ctgcccccgt caagcacgat 3390841 aatttcgtcc atatcgagca tccagtgaag gcggtgagtc gcgagaaaga cgagcttatc 3390901 ctcaaataaa tccagcatcg tttcttttat ttcatattct gtttcgatat caagatgggc 3390961 ggtcggctca tccagcagca ggatcggacg gtttcccaaa aaggcgcggg ccagcgcgac 3391021 acgctgtgcc tggccgccgc tgagcgcccg gccgccttcc ccgatccgcc cctctaatcc 3391081 gtcaggaagg ttgttcacca gctccgtcag tcccgctgag gcagcagcac gtgttgtatc 3391141 ctctgccgaa gcgcttggat ggtagaagcg aatgttgttg ccaagcgtat catcaaaaat 3391201 gtacggatgc tggggaatgt aaagaaggtt cttctgccag ctgccgtcct gcaaatggga 3391261 ccggcttgta ccattaacct caatcatccc gccatccggc tctaaaaatc cgccgagaat 3391321 atcaattaat gttgattttc cggcgccgct tgcaccgata atgccgattt ttttcttgcc 3391381 tttgaatgag agatgaatat cagacaccga acggccgact gacacgcctg acagcttcag 3391441 ctcatcctga tcggaccaag cttcgagctg aagcggcgtc tcttctttaa aaccaggctg 3391501 cgacaaaatc tcttgaatgg tttttcctgc ttcctggccg ttcagcgttg catgataatc 3391561 attccccact tcccgcaccg gcaaaaaata ctcaggcgcc agaataagcg ccgttaaagc 3391621 agggccaagc aaaatatcgc cgtcaatgag gcgcaggccc agaaatactg cgactgtcgc 3391681 caccgacagc atcgtgaaaa aatcgagggc gaatgatgac aaaaacgcca cccggagtgt 3391741 gctcatcgtt gccttgcgat accgctcact cacatagaaa atatttttgc tgtgtgactt 3391801 gctcaaacct aggaaacgca atgtctccag cccgcgaaga gaatcaacaa aatgattgga 3391861 aagtctctga taggatttcc actgacgatc cgcttttctc tgcgcgacaa ggccgaggag 3391921 aatcataaag atgatcagaa tcggcatagc agcgactaaa atgatggctg atgtccgatc 3391981 ctgaaaaaac acataaatga caactgccgc aggcacaatc gccatgctga ccattttcgg 3392041 cagaaacagc tccaggtagc ggcggaactg gctgatgcct tccatcgcca gcgtcaccat 3392101 ttgccccgtc ccctctttct ttgcaaagcg ggggcctaat cggaacagct gatcaagaaa 3392161 acttttcctc aaatctgctc ctgtccgggc ggcgtattga tagacgattt tctgtcgcgc 3392221 caccgtcatc ccgtgccggg cgataaaagc gatgaggaaa aagccgatca ccggtaaaag 3392281 ggaggtaatg cccttcccgt tgaacagtcc ggttacggcc tcactcagcc actctgcctg 3392341 cataataatg gcggctgtct gaatcaacgt taaacaagta atcaaggtga gaatccgctt 3392401 cattccttta tatcgaaaca ggtcttttcc cattaataag tcataggctc cttatggctg 3392461 acgcgcttcc ggaagacata atagctccag atctggctgc cgatgacgaa cggcaatagc 3392521 gttaatgctg caattgacat gactttaagc gaataatctc cagaagaagc gttagctact 3392581 gttaaatcgt atgcgctatg aagcgagctg accattacac gagggaatag ggaaataaag 3392641 atcattccca cggtcagcgc cagaccagcg cctgtcatcc caaatgtcca gccgtctttt 3392701 ttcttacgaa taaatacagc cgcgagcata aagcagatga caatcaaaac agcgagcgga 3392761 atggtaatct cgccgcggcg tgtaaacatg tctgtctgat acgcagaaag ggccgcgaag 3392821 gcaagaaccg ctacaaaaac aacacccatt atcttttgcg ccattttccg ggcgcggttt 3392881 tgcaaatcac caatcgtacg cagcgtgata aacattaatc catgctggaa gcaaagaagc 3392941 gttaccgtca caccgccaag tatagaatat acattgatat aatcagatac atgtgcgtga 3393001 atgttcatgt cggcatcaat cggcatcccg cggaataatg tcgtgaacag cacaccaagc 3393061 acaaacggag gaattagact gccgaaaaaa acgacccagt cccaaacctt tacccatttt 3393121 aaatgatcca ccttgccgcg gaactcaaac gcgaccccgc ggcccattaa cgcaagcagc 3393181 actatgacaa acggaatgta ataaccgctc agcatcgttg cataccagtt tgggaatgcc 3393241 gcgaaaatgg cgcctgcgcc agtcaaaagc cacacttcat tcgcgtccca gaacggcccg 3393301 atcgtgttga tcagcactct gcgttctaat tcattatggc caagaaaacg ggtcgccatg 3393361 ccgaccccga aatcaaagcc ttccaaaaag aagaatccta caaacaatac agcaacgagt 3393421 ataaaccaaa gatcatgaag agatgccatg gtatacctcc tgactaaatg gatctgttga 3393481 tacaggcaca tcatgatgat tatcatgctc cgcacctttt ttaatctcac ggataaacaa 3393541 gaagacaagc agtgcaccaa gaatcatgta catcacaccg aatgcgatga ttgagaataa 3393601 caaggaaccc gctgttacgt taggcgacac agattgagcg gttgtcatta accccataac 3393661 cgtccaaggc tgacgtccga tttctgtcat aatccagccc gcggagtttg caagaaacgg 3393721 gaaggaaatc aacgcgatca tgatgcgcaa ataccatttg ctgttttcaa gctttttacg 3393781 gcggtttaac caaaggccgc ctaacgcagc aagaatcatg acaacacctg ctcctaccat 3393841 gatgcggaag ctccagaatg tcgttttcac tggcggaatg tagtcgcctt ttccgtatat 3393901 tttttcgtac tcagcctgaa gggttttcat ccctttgaca cttccgctga atttctgata 3393961 agccaagtag ctcaaggcat aaggaacttt gatttcattt gagctttttt cattttttgt 3394021 atcgatcgtc gcaaaagcgg tccaagcagc agggtcaccg ctgtcttccc ataggccttc 3394081 actggcagcc attttcatcg gctgtgattc catcaagtgc tcagcctgca tgtgtccgct 3394141 aaggccgacg ccaagaccgg cacaaagacc gacgatcatt gcgagtttaa aagattgctt 3394201 aaagaacggc acttcttttt tcttcagcag tttaaaagca ctcactccgg caataaagaa 3394261 agctccagtg gcaagcgcac cgaaaataac gtgcgggaat tcaacccaaa gctgagggtt 3394321 tgtaatcaac gcgccaaaat cattcatttc cgcgcggccg tttttgatcg taaagccgac 3394381 cggctcctgc ataaaggagt ttgctgttaa aatccagaaa gatgacatga tcgttccgaa 3394441 tgatacgagc catatgcaga gcgcgtgaat tttcttcggc aggcggtccc agccaaaaat 3394501 ccataatccg ataaaaatag attccatgaa aaacgccaat aatgcttcaa tcgcaagcgg 3394561 agcgccaaat acatctccga caaaacggga gtaatctgac cagttcagtc caaactggaa 3394621 ttcttgcaaa atccccgtta caacaccgac tgcgaaattt attaagaata agtgtcccca 3394681 aaactttgcc attttgagat acagctcatt tttctttaca agataaagag tctccatcaa 3394741 cgcaaccata aacacaagcc cgatagacat cggcacaaac aagaagtgaa acaacgttgt 3394801 tgatgcaaat tgtatgcggg ctaataccaa ttcactcatg ctttctcctc catttccggt 3394861 taaaactgtt aatttgctca ctacttcaca aatagaaccg agactttgat cagtaattca 3394921 caaaatagac gaaaaaaata ttgctcaata tttcacaaat gtgtcaaaaa gtcatccaat 3394981 atgatgcaag attgccagac tgaccaaatg acacaatctc tgactggttc atattaagta 3395041 ctttacaacg attcatttca aaaataaagc ctaaaatacc taaaaagtcc cgcactatgt 3395101 gacggatttt tgtctatttt gttgcttatt tatgtcggct gctaggataa atgacccttt 3395161 attatcgtac atcaacacat cgttccttgc gaacaaaatg cttgcccccg ccccagcact 3395221 cgagtctcag cattccgtct taaaccgatt ttagtcagaa tgcctctttt catttgaacc 3395281 ggtaagagga gaaaagttga atagtaaatt tttaatatat taataatttc aattttttag 3395341 tatacttaac atagtgaaca atttcactgc atcaagaata ggggaggttt ttcaatggga 3395401 gagcttcaaa cacacatgca attgcaaacg gatacaattc acgaaggggt tcgaaaagag 3395461 aattggtttg cgaaagccat gaatataaaa gtaggcatca taccgcttcc tgtgtatgcc 3395521 ttgctgttta tattaatcac tgtttttgtt atgcatcacg atgtaaaaag tgacattttg 3395581 acatccattg ccgtcatggc gtttttcggg tttacctttg cccaaatcgg caaatcgata 3395641 ccgattgttc gttctatcgg cggcccggcc atcctagcta cttttattcc gtccgctgtc 3395701 gtgtactatc acctgctgcc taatgatatc gtcaaatcca ccacagaatt tacagaaaac 3395761 tcaaactttc tatatttgtt tatcgccggt attgtcgtcg gaagcattct cggcatgaaa 3395821 agagaaacac tcgtaaaagc attcatgaaa atctttattc cgcttattgt cggttctgtc 3395881 acagccgcta ttgtcggact ggctgtcggg acattgctcg gactcggatt tcagcatacc 3395941 ctgctgtaca ttgtcattcc gatcatggct ggaggagtcg gagaaggcgc tatcccgctg 3396001 tccatcggat attctgacat catgcccatt tctcaagggg aagcgtttgc acttgttctg 3396061 ccatcgatta tgctgggcag cttgtgcgcg attattctag cgggattgct gaaccgaatc 3396121 ggaaagaaaa aaccggaatg gacaggcaac ggcaaagtgg accgctccga agaagagtcc 3396181 cctgcgctgg aggaatctca aagcggacag caaatgttca acctttcttt atttgcgtca 3396241 ggcggtatcc ttgctgtttc tttatactta gtcggcatgc tcgctcacga ttttttcggt 3396301 tttccggcac ccgttgccat gctgttactg gctgttctaa tcaagctgtt cagattggtg 3396361 cctgcctcaa ttgaaaatgg cgcgtttgga gtgtcccgct tcttttcaac agctgtgacc 3396421 tacccgcttc tctttgcgat tggggtatcc atgacgccgt gggacaagct tgtcgccgct 3396481 tttaacctca gcaatattat cacgattctg tctgtcgttg tgaccatgat ggccgttggc 3396541 ttcttcactg gaaaatggct gaacatgtat ccgattgaaa ccgccattat taatgcatgc 3396601 cattctgggc aaggcggcac gggtgacgtt gccattttaa gcgccgctga aaggcttgag 3396661 ctaatgcctt tcgcccaggt gtctacccgc atcgggggcg cgattacagt atccttaacc 3396721 ttattgctgc tgcaccagtt ttattgatcc ccgcaagcaa gttcttcgtc aaacgaaaga 3396781 gcttgctttt ttgcatgtcc atgtttttgc aagttcccat cccatgctat agtaatagtt 3396841 ggaaatacta gatagaaagg aatctggcat gcctatggga actcatctat ttctctttat 3396901 gcttctcggg ctgggatttt atttgatatc agccctagct gcaaaactca ttccggccat 3396961 agacttctgg attgatattg ttctatgggt cggcgctgcg gcttacatct tctctcatct 3397021 ctcattcatg gacggcattg tctcactcgc gacaatgttc tactgctatt ggaccgcaat 3397081 ggatctcatt gtttcagagc gtgtggaaaa accttcggga gactggcagg aaatcgagct 3397141 tgccaaaaac aaaacacgcc tcctgtcaga cattacgctg accgccattg tgtttgcagg 3397201 ggctgtcatt tttttcatct atggacctga cacaagccct ctcaaatatg tgatccttct 3397261 cggaatgatc tccggcggag gggcacttgt gaagcgaata ctgaatgttt ttagcgtaaa 3397321 ggttttttat tcagcagcct tagaaaaatt gcatatcagc tcacactatg aaacccgtac 3397381 atacccgctt tccgatttga agaacattca gcttgaatca acagcagatc tcttaaagct 3397441 ccatccgctt ctgacgatgt attcatcccg tttagatttg acaacaagct ttcagcaagt 3397501 cattaaactg tctcttcccg gcgaaacact gtttctgacg gtgaaggaac cgcaaaaatg 3397561 gaaaacaatt cttcaggaat acacagatgc agaaaacaat gtggacaatg tgatttctgt 3397621 tttgccgttt tatcatcgaa aaaatgtgaa gcggctgctc ggtaagcttt attttgccgc 3397681 cagcgtaaaa ggggtatccg cttacgcctt attggtgctc gcgttatacg cattacacgc 3397741 ctctccatgg gtcatggctg ttgccgtaat cctatattgg gtattcaaca tgtatatgtc 3397801 agaccgtgtg ttgcgggcgg cgatggacgc caagtcttgt catcatccgc atgtacaggc 3397861 cgcggccgat aagattttca gatcggccgg catttcccat gtccgcatat acgaaacgga 3397921 gagtgatgat tacaacggaa tggcagtagg catgaatgtc gggaggtcaa tggtcatcct 3397981 gacaagcgcc acactaacac ttccacagcg tgtcattgaa ggcattctgg cccatgaggc 3398041 gattcatatc aaaaaacgtg acgttctgtc atcacagctt ttgcgttttc tatatcttgg 3398101 agctgtcgtg gggattttcc tcttgtttga gcagcatatc acccatcccg aggcccacaa 3398161 aattgcgctt tgggctttca ttatggcaat cattatccta ttccagctct atcaatcctt 3398221 ttgttcacaa tggatggagg tgcgtgctga caaccttggc gcatcattgc tggacggcgg 3398281 ttacaaacaa atggctgaag ccttgagaat cttggcggtt cggcaagatg aggatataca 3398341 gaaacaaagt gcctatagct ctgaagcagg tgaagacgag cttcaaattg attctctcac 3398401 ccgtgataaa agctggtttt tcagattgat tgattttcag ttcgctcctc atcctcctat 3398461 gtattggcgt gtcggcactt tattgtcaaa caaaggacat ggggtgctaa agcgctggct 3398521 cagagaccga ctgaaagaat cgatcacttt gaaatgaaac cggtcagcgt ttcatccgta 3398581 taacagatat ggtgaaaaaa gggagtgacg cgaagtgatt gtgatcatct tattgtttat 3398641 atctattatt gtttttcttt cagtcattca gccgcagccc tcgaaaaaca aaagccgcca 3398701 gcaggcggac agcgggtatt tcggttattc agatcatagc tcacaccatg atggatgcag 3398761 cagtgacgga ggtttcagcg attccggctg tggcggcgga gggggcggcg attaaacgcc 3398821 gccttttttt atttcattga ttcgatgtac gcaccaaaag ccgagcctga catgcctggg 3398881 gacacgcgca cacgatggag ggcatacatt ccctggtctc tcgaagccgc gcccggttct 3398941 gtcgtcacgc ccatttgata gcctgttttt tcagcggcct tcagcgtctc ctcattgtag 3399001 cgccctaccg gatagctgat gatggtggtt tgctgatgaa acatgttgtc gaacagcttt 3399061 ttcgaatcag ccatctcact ttgctgctgt tgaggcgtta atccgttcag ctcaaggtgg 3399121 tcaatcgtat ggctttcaat cgatatgccg tgctgtgcca tttccttcat ttgttcctct 3399181 gtcagatggt gcttatgtcc gatcgatttg ccgatcataa aaatcgttgc cttcatcccg 3399241 tactttttca gcaccggata cgcatcttga taattgtcgg tgtacccgtc atcaaatgtg 3399301 atcagcacgc acttctcact cggtttttta tcctgcgtca gcatgagaga tgcctctttc 3399361 ggcgttaatg tctgatagcc gttatcatga agccacttca tatgcgcctc gaattctttc 3399421 tttggcacac ggaggctgtt tcctgaagaa atgctgtggt acatcaaaat cggcagcttt 3399481 gccggtttct ctgttttgat ccatgcggat gtatcgtctt cttttttctg aacttgtact 3399541 gccttttttt ccggtttctt ttgttccgct tttggcatcg gctgctctgc attcgcctct 3399601 tgatcagcac aagccgcaag agccaaacag ctgcccaaaa gaaagatgct taaaaacaat 3399661 cgtttcatcg ttctcctgct ttctgtctat ttcttcctcc tttttcatcg gtttgattct 3399721 gagattttca atagcaaaaa accggacatg tctccatgtc cggttttttt gatcttatcg 3399781 gattctcact tctgtctcac tgtcaaagaa atggccttta ttcatatcaa atgcaaccgt 3399841 cagctcatcg cccgattgaa tatcgaggcg ggcgtcgatc cgcgcaataa agtcttggtt 3399901 gtctatctgc gaataaatca taatttcaga accgagcagc tctgcaacat taattttcgc 3399961 cttaatcgaa gagttcttat atgattccac gacaatcaat tcatcatgta tatcctcagg 3400021 acggatgccg aagatgacct ctttgccgat gtagcctttt tcacgcagca ctttcatttt 3400081 tccttccggg acggttaatg ccgcagaacc gattttgatt aagccatccg tgagctttcc 3400141 tttgaaaaaa ttcatcgccg gtgatccgat aaacccgccg acaaagacgt tttcagggaa 3400201 ttcatataca tccttcggcg tcccgatctg ctgaattttc ccatctttca tgactacaat 3400261 ccgtgtcgcc attgtcagcg cttctgtctg gtcatgcgtc acataaatcg ttgtagtctg 3400321 caatctctgg tggagcttaa tgatttccgc ccgcatttgc accctcagct tcgcgtccag 3400381 gtttgacaaa ggctcatcca tcaggaacac ctttgcatcc cgcacgattg cccggcccag 3400441 cgcaacccgc tgtctctgtc cgcctgacag cgctttcggt ttacggtgca aatattcctc 3400501 aagcccgaga attttagcgg cttcttcgac tctttttttg atttcaggct tcggcatttt 3400561 ccgaagcttg agcccgaacg cgatattatc gtagaccgtc atatgcggat aaagcgcgta 3400621 gttctgaaat accatcgcga tatccctgtc ctttggcgct acatcattga cccgttttcc 3400681 ttcaatataa aaatcacctt tcgaaatttc ttcaagtcct gcgaccattc gcagcgtcgt 3400741 tgatttcccg cagccggacg ggccgacgaa tacgataaat tccttatcgg caatatgaag 3400801 gttaaagtca tcaaccgccg gttccttctg atcataaaat ttataaatgt gctccatccg 3400861 caattcagcc atctaacatc cccctttgtt attgtaaacg ctttcttata ttgagtgtaa 3400921 cagcaattcc ctctcgctaa aatgggcagc gttcataaaa tcacccagcc atttttcgtg 3400981 catatttcca atttattctg aactttcatt ttgcaggcag ataaaatagg caagaagcgc 3401041 gcctttgtac gatttgatat ctatccctga ccgctcaata aatttatcaa tccgatattg 3401101 caggctgttg cgatgcagat gcagcttttt cgctgttaat gtgacgtttg agttgttttc 3401161 aataaacagc ttaatggtct tccttagctc agattcactt ccaaataaaa gctcagcttc 3401221 ttcagagagc agtgtttcca gtttttcttt ttctgtttct aataatagaa aaggaaagat 3401281 catctcaaag gtcacactct gcacctgagg cagccgtttt tcagcaaaca ggaaatacgc 3401341 ctgttcacga gcgtaatgtt ttcgcagaca ctcatccggc tcgtaaaatc ttccggcgta 3401401 aaaacggaca ctgaagtaga aatcactttc aagaacctta gcgagcgatt ccagttcgtc 3401461 cttctccgcc gccgcttcac tttcctgctc gacaatcaca cctctgtcct catggatcca 3401521 cacaatcaca aaagacaccg gccaaaaatg gcgaaccgct tccgtaaagg acgtcctttc 3401581 tattttgccg aataaatgaa agtgaacaaa tctcgtccgt ttctttatat acgccggcaa 3401641 ttcccctctg gaaaaaagga acgaaaacca cttgttttcc tcaggtgatt tcatagacag 3401701 ttgattgccc tcatccgcag gcgtcaaaaa tgactgcagc accaatactt ctttttcact 3401761 gatctctgtt ttcggaatgg agatatatct ctgattgctc tcatcaaaaa aacatagaca 3401821 gccttccctt atgcaaagct cctcagacac aatcgaaccg ggataaatag ccagcagcga 3401881 tttcatagag tctcctctct tatgtaagga tctgtatatt cagtataagg cgaaacacac 3401941 atgttctcca ctaaaaaaga gtatatccgg tatagataga cgagaaactg aaagggaaac 3402001 ctcattcgtt tacatattgg cttcagcgga aatagaagaa gacatgcagg accaaaggag 3402061 ggtcatctta tgagtttcga aacgttaaac aaaagtttta tcaacggaaa atggactggg 3402121 ggagaaagcg gacgtacgga ggacattttg aatccgtatg accagtctgt gatcacaaca 3402181 gcatctttgg caacgggcaa acagcttgag gatgcgtttg acattgcaca gaaagcccaa 3402241 aaagagtggg ccaagagcac gacggaagac cgaaaagccg tgctgcaaaa agcgcgcggc 3402301 tatttacacg aaaaccgtga tgacatcatt atgatgatcg cccgcgaaac tggcggaacg 3402361 atcattaaat caacaatcga gctggaacaa acgattgcga ttttagatga agccatgacg 3402421 tatactggtg aattaggcgg cgtcaaagag gtgccatccg acattgaagg gaaaaccaat 3402481 aagatttacc gccttccgct aggtgtcatt tcatcgattt ctccatttaa tttcccaatg 3402541 aatctatcca tgagatccat tgcgcccgca attgcgctgg gtaacagcgt tgttcacaag 3402601 cctgatatcc aaactgctat ttccggcggg accatcattg cgaaagcgtt tgaacacgcc 3402661 ggtcttcctg ccggtgtcct taacgtcatg ctgacggatg taaaggaaat cggggacggc 3402721 atgctcacca atccaatccc gagattaatc agctttacag ggtcaacagc agtcgggcgc 3402781 cacatcggtg aaatcgccgg tcgcgccttc aaacgaatgg cacttgagct cggcggcaac 3402841 aatccatttg ccgttctttc agatgcggat gtcgatcgtg ctgtggatgc cgcgattttc 3402901 ggaaaattta ttcaccaggg acaaatctgt atgattatca acaggatcat cgttcatcaa 3402961 gatgtatacg atgagtttgt agaaaaattc accgcccgtg tcaaacagct tccgtacggc 3403021 gatcaaaccg atccgaaaac cgttgtcggc ccgctgatca acgagcgcca aatcgagaaa 3403081 gcgctggaga tcattgagca ggcaaagaca gacggcattg agcttgcggt tgaaggaaaa 3403141 cgcgtcggaa acgtgctgac gccgtacgtc tttgtcggtg cggacaacaa cagcaaaatt 3403201 gcccaaacgg agctgtttgc cccaatcgca accattatta aagctggcag cgaccaggaa 3403261 gcgattgaca tggcaaatga tactgaatac ggcctcagct ctgcggtttt cacttctgat 3403321 ttagaaaaag gcgaaaagtt cgccctgcaa attgacagcg gcatgaccca tgtcaacgac 3403381 cagtccgtca atgattcgcc gaatattgcc tttggcggaa acaaagcaag cggtgtcggc 3403441 cgtttcggca atccgtgggt cgtcgaggaa tttaccgtga cgaaatggat ttcgatacag 3403501 aagcaatacc gcaaatatcc gttctaaatg aaaaaatccc tctgtttcaa gtacagaggg 3403561 atttttcttt atttagatat atccacaaac ccttcgccaa acacatcgcg tacgtcatgt 3403621 acgatcacaa acgctttttt gtcgcagctt ctaatgattt ttttcagcat agacagctcc 3403681 tgtttgttaa tgacgatata caaaatctct tttgactggc ccgtataatt tcccttccct 3403741 gataaaatcg tcacgccccg atccatcaag gtatttacct gctctgcaat ctcactctta 3403801 ttttctgaaa tgaccgtaat ggcttttttc gtattcaaac cttcaataat gaagtccatc 3403861 actttggtac cgatatacag catcacgatc gtaaacatca ttttttctgc accaataata 3403921 aaataagagc taaatactac gattaaatca aaaaacaaga gtgcatagct gatattccag 3403981 tctaaatatt tattagcaat tctggccaga atcgcggaac cggccgtcgt cccgccgacc 3404041 cggataatca tgccgatccc gactccggca aatacacctg cgaaaatcgt attaatgatc 3404101 aattcatcag acggaatgct ccacccatgt gtcagatgaa gaaaaagcga atttgccgca 3404161 accgcaatga tcgtataaac cgttgttttt ccatcaagaa acttgtagcc gattaaaagc 3404221 aaaaacgcat ttaagataaa gttcgtgaca ccaggagacc attgaaacag ataatacaaa 3404281 atcagcgtaa tcccagtgac tccgccttcc ccaagatcat tgggaatcgc aaataaatta 3404341 accgcaagcg cgaagaaaaa agcgccaatc acaagcataa gtacatccag cattctcttt 3404401 ttcatcacga aaacactcct tttcattgtt ctgttctagc aaataaaaaa acccaggaga 3404461 acgctctcga aaaagagcag aaactcctgg gcttttatcc caccgtgtca taacagccaa 3404521 gctgctatgt gttttctctc ggtcacagtc caatttgcat tgcggaaccc tagaaaacca 3404581 ctgtttttat catatccttt tcactttcca atattagcat tataagggac ggttcgaatt 3404641 ggttcaaggg gtatttgcgg agttttcatc agataagctg gaaaaaaata cgatttatct 3404701 attaaaaaag aacagatata accgataaga aaaaaagcat atattttaca agcgaatgta 3404761 actataaatg ataataatta taagaaattc ataattttat attgactaag agaaataata 3404821 taggcattat agtacatatg tttcgtacat tttattacat aggaggaaat ataatggcag 3404881 gaaaactagt accctgtaaa gcttgcggtc aagaaattgc aaagggtgta aaaaaatgtc 3404941 ctaactgcgg taaggatcaa cgtaactttt ttatgcgaca taaaatcatt acgtttattc 3405001 tcgcagttgt tgtcatcatt attatcggta atatgattgg cggcggaggc ggctcagaag 3405061 ccacttccaa aacatcaagc agcagcaaag cagaaactga aaaaacatac aatatcggtg 3405121 ataccgtaaa aactgaaaaa actgaagtga cggttacgaa ggtagaggac agagatactg 3405181 tcggtactca atatgttgaa aagaaagcat ctgagggagg tacaattgta gctgttcaat 3405241 atacaattaa aaacgtatct aaaaagccga ttagctcttt ttcaattcca actgttaaat 3405301 tagttgatgc tgatggtact tcttatgatt ctgatattga tgcttctgta aactatgcaa 3405361 ctgagacaaa agttgataac tctaaaattt tgagtgatct aaatcctaat attaaagtaa 3405421 caggtgtaaa agcatttgaa gttgacaagg aagcttatgc aaaaggcact tggaaactaa 3405481 aattcagtaa tgatgttatt gtgaaaatca aataacagct aacaagggtg cctgtttagg 3405541 cacccttgtt ctttaaaaaa ggccttctca attgagaagg cctccattct tattccgcac 3405601 tcttataccc attcacatta gaagactgcc atctccagga atcagcacac atttcctcaa 3405661 ggccgcgttt cgcttcccag cctagttctc gcttggcttt cgcaggatct gcaaagcatg 3405721 tggcgatgtc tcccggacgg cggtccgcaa aacggtatgg aacctctttc cctgacactt 3405781 tttcaaaggc tttgaccatt tccagcacgc tgtagcctgt gcctgttcca aggttgtatg 3405841 catcggctcc tgtagagttc aatacttttt ccagcgcctt gacgtggcct tctgcgagat 3405901 caacgacgtg aatataatcg cgtacgcctg tcccgtcttt tgtcggatag tcatttccga 3405961 atacgcttaa ttgctcgagc ttcccgactg ctacctgtgc cacatacggc ataaggttat 3406021 ttgggattcc gttcgggtct tcaccgatcc gtccgcttgg atgcgcgccg aacgggttaa 3406081 agtaacgaag cagcgcaacg ctccactcat tgtcggctgt atgcaaatca cgcaatattt 3406141 gttcaagcat gagcttcgtc tgcccataag gatttgtcgc gcctaatgga aagtcttccg 3406201 taatcggcga tgtttccgga acgccgtata ctgtcgcaga tgaactgaat acgattttct 3406261 tgacgccgta tttctccatg gcctcgcata aaataaacgt tcctgtcaaa ttgttatgat 3406321 aatatttgag gggaatcgcc acagattcgc cgactgcttt taaccctgca aaatgaatca 3406381 cagcttcgat ttcattttca gcaaaaacgg aatctaccgc ttcccggtcc aataaatccg 3406441 cttcgtagaa cgttaaatct tttcctgtaa tctccttgac acggttcagc gcttcagctg 3406501 aactgttgga cagattatca agaacaacaa tctcgtagcc gctgttcaat agttcaacac 3406561 atgtgtggct gccaatgtaa ccggcaccgc cagtaacaag tattgccatg atgtaaaccc 3406621 tcctaaaaaa tgacctgttt tcattatata gtgtttagaa ccggtccaca tccattttta 3406681 agaagtttaa tcgtttatta atagtttttt catatttttt agcttaaacc cttgccagca 3406741 attcgataga ggtttcagca agaatgtgct ctttcatttc ttgatagagc tcattcaagt 3406801 aaaagcccgg ctgaagattc agctcagcat ctaaagcata gaccgtcaat gtatacgcat 3406861 gatccttgtc aggcggtgtc ggcccgcaat actggtgaat cacctttgga tcgttgcttc 3406921 ccgcaagcgg tgaagcaaag ctgttttgcc cttgtatcat caagtcctgt ctttcctcac 3406981 tcgcatgttc aggaagctct ccgatgtaag ccggaatatt agccgctgtc cagtgaatcc 3407041 agctgaatcc gcatacggga atggcgtcat gatcgatgaa agtaagtgcg agcgtctttg 3407101 ctccggacgg gatgtcatca aaatgaattg gaaaggatac aaatgggttt ccttctctct 3407161 tatatttttc atccgcgtat tttgaatact tgtcatgtaa atatggattt gcttctacgt 3407221 atatgttcat atgaatccct ctctctattt tctcgttcta taggtatact aaacgaatcg 3407281 atgtataatc agtgataaac aaatacgcat gtaaacgtaa caatttgtta tggataactt 3407341 gcagtgaagg agatatttca tggatttaaa atggctgcaa acctttattg ccgcagcgga 3407401 atcagagagc ttcagggagg cggctgagca tctgtatctc acacagcctg ccgtttctca 3407461 gcatatgagg aaattggaag atgaactgga catgaggttg tttttgcata gcggaagacg 3407521 agtcgtactg actgacgaag gcaggctctt tttgccttat gccaaagaaa tgatccatgt 3407581 ttaccaagct ggaaagcaga aagtcagtca atggaaacag gggtacagcc gatcactcac 3407641 gctggccgta cacccctaca ttgcgtccta tatcttgcct cgctttctgc cagcctatat 3407701 ccaaaaacat ccgcatgtcg agctttcaac tcatgtggct ggatctgacg ctattaaaca 3407761 agcggtggaa cacaatgaag ctgatattgg tttgtcgcgg aaagacccga acaccaacac 3407821 tctttattat cagcatatat gcgaaggtac gctttgtctg gcggctcctt tccaagaaag 3407881 cagaccggat gctgcatccg tcttaacccg ctatcggctg ctaacgcatg atcatccgtc 3407941 atatggggat gcctttttag ataacatccg atcacattac ccgtatcttc aaatgatggc 3408001 tgtcgggcag acggatacgg ctgtccacat gatgaaagcg ggaatggggg catctttcct 3408061 ccctacctac attatcaaac aggaagaagc cgaaaaaaag ctgatggctg tcagcacgcc 3408121 tgcacatcta gaattgcctg cgtcccaaac gtttatgatg tggaaaagaa acagcgaaga 3408181 cattcagcat tttcacgcca tgttacatga ctttatgcag cgcgaacaag tatagagctg 3408241 aaaaatcaat ctgccggttg acgtttttct ttcctatttt cgctatgctt aatgcagaaa 3408301 ggatttgatg acatggcgat gagcccttat atttttattg tattgattct tattatttta 3408361 tcgatgtatc gagaaagaac ggtaaagccc gggaagttgc tgatcattcc actgttgctc 3408421 ttatggggcg tatctgcatc gtttcagccg gcgtattttc attccgtatt acatgtggcg 3408481 atcagcggca ttttattact gatcgggctg gcctgcgggt ttggcattgg gaagatggta 3408541 aatgtacgga ttcacccgga aaccggaaag gtcacttcac gcggctcact tgggagtgtt 3408601 atcctcattc tagtgatact ttctttgcgc atggccgcga gaacatggct gcctgagagc 3408661 aacgagatgt ttattgccat tattcattct atgttcttcg ttcccctcgg caccatcaca 3408721 gcccgcaaca tcatgcttta caaagcatac agacgactga ccgctggcaa agtatccatt 3408781 caataaccga aagaaggacc agcatgaacg gacaaactcc ggctcggcac tactacaaga 3408841 agcttgtgcc gagccttatt ctcattttga attgcataca atttttatct catccaacta 3408901 aggctgatcc cattttgtta gcatttgtat ttgcggtata cttagcattc atttggatca 3408961 ttccctatgt ggcatccact gctgttagtt tgagcatatt catcggactc tggctcctga 3409021 ccgatttctt ttgggctgtt tccggccaag agcagggtgc cgcctatttt ttgattgtat 3409081 ttttaatgat atatgccgcc tttagactcc cttcacggct atccttgatc ttcacagcat 3409141 gtttaattgg aggcaacata ttactcctat cctcacaagg gggaagcttg aataccatca 3409201 tcagcaacat ctcgatcatg ctcggtctgt acgtcctctt ctcctccatg cgtttcagac 3409261 gagaagcgag aagggaggct gaacggaatc atgctgaatt ggcaaaaatg catgtgcagc 3409321 tggagcatgc tcataaagaa ctccagaaag cgcatgcaga gctgcaggag gcttctgttc 3409381 tttcattaag gtacgcggtc cttgaggaac gtacaagaat tgcccgcgac attcatgaca 3409441 gcatcggtca cgagctgact tctgtgattg ttcagcttca atcccttccc tatatcctta 3409501 aaagcagcaa ggaggattca gaaaaagtca ttcaaaatgt actgagtgtc gccagggagt 3409561 gtcttcaaga agtgcggtct gttgttcacc aaatgggccg tagtgaatcg atggtggggc 3409621 ttaccgcttt gcgggggctc attcatcaag tggaggaacg gagcggcttg cacgtttctt 3409681 tagatactgc cggactgtca gaagagtctt ggcctccaaa cgtgagcgaa acgatctacc 3409741 gcatcttgca ggaagcgctg accaatatca ttcgtcacgc tgacgcttct catgcggcgg 3409801 ccgtcatttc taatgacaag tcccatctct atgtcacaat caccgacgac ggacaattca 3409861 ccggcagcct tacttatgga tttggcctga caggaatgaa agagcgcgca gaaaaagcag 3409921 gcggttccct tactttcagt gccgtacagc cgagcggcct gaaaattgag ctgtcattgc 3409981 cgctcatgac aacgaataag gagcaaaaag atgaacaaag ataaaatacg cgtagcgctt 3410041 gccgatgatc agccgcttgt gcgtgaaggc ttccgctacg tcatcaacgc acagacggat 3410101 atgacggttt ctggcgaggc cggcgacggt cacgatatta tagcactcgc aaaacaaaca 3410161 aaacccgatg tcatcctcat ggatgtccag atgccgcgtt gctcaggcat cgaagcggcg 3410221 aaagacatta tgtccgcact tccaaataca aagatagtca ttttaaccac ctttgacacg 3410281 gaagaatacg tatttgaagg catccgtgcg ggcgcagtcg gctatctgct gaaggataca 3410341 cttcctgagg agttgataga tgcgattcgc gctgcggcca gaggcgaggc gattttccgt 3410401 acagtcacag ctgctaaaat catcagtgag acatttcggg cgaaacagca aactcatgcc 3410461 gaagaactgg cagagccgtt caccaaaaga gagcttgagg ttcttcagca aatggcctac 3410521 ggactgagaa atgaggatat tgctgaaaag cttttcgtca gtgaaagcac tgtgaaaacc 3410581 cacgtgcacc gcatcctgca aaaatgcaat gcccaagacc ggacacaggc agtcgttttt 3410641 gccattcgaa acggtattgt gcaatagaaa tctctcatcc cgccatgcta aaataagaca 3410701 aaggagatga ttggaaatga aagaagaaat cattgaacgg tttactacat atgtaaaagt 3410761 cgatacacag tccgatgaat ccgttgacac ttgtccttcc acacccggcc aattgacatt 3410821 aggaaacatg ctagttgatg aattgaagtc catcggcatg caggatgcag ccattgatga 3410881 aaacggctat gtcatggcaa ctcttccctc caatactgaa aaagacgtgc cgacaatcgg 3410941 ctttctcgct cacgtcgaca ccgctacaga ctttaccggc aaaaatgtga atccgcaaat 3411001 catcgaaagc tatgatggaa aagacatcgt tcttaacgaa cagctgcagg tcaccctgtc 3411061 acctgatcaa ttccctgagc tgtccggcta taagggccat acactcatca ccacagacgg 3411121 caccaccctt ctcggcgcag acaataaggc cggtatcgct gaaatcatga cagccatgga 3411181 ttacctcatc aaacaccctg aaatcaagca cggcacaatc agagtcgcct ttacgcctga 3411241 tgaagaaatc ggaagagggc cgcacaaatt tgatgtgaaa cggttcaatg catcctttgc 3411301 ctacacggtt gacggcgggc cgctcggcga gcttgaatat gaaagcttca atgccgctgc 3411361 cgcaaaaatt acgattaaag gcaacaacgt acatcccgga acagctaaag gaaaaatgat 3411421 caactctgcg aaaatcgcga tgaagctgaa cagcctgctg ccggcagacg aagcgcctga 3411481 atatacggaa ggttatgaag gcttctacca cctgctgtcg attcaaggag acgtagagga 3411541 aacaaagctc cactacatta tcagagactt tgacaaagag aatttccaaa acagaaaaga 3411601 aacaatgaag cgtgccgttg aagaacttca aaacgaatac gggcaagacc ggattctgct 3411661 ggatatgaac gaccaatact acaacatgag agagaaaatt gaacctgtca tcgaaatcgt 3411721 caacattgcc aagcaagcga tggaaaacct cggcatcgaa ccgaagattt cccccatccg 3411781 cggcggaacc gacggatcac agctgtccta catggggctt ccgacgccaa acatctttac 3411841 aggcggggaa aacttccacg gcaaatttga atacatctca gttgacaaca tggtcaaagc 3411901 cgtaaatgtc atcgttgaga ttgcaaagca gtttgaagcg caagcataac gccaaaagcc 3411961 agtccaaaaa aggactggct tttttgtgtg aaaatgaaac attttaaaca cgtcctccgt 3412021 aaaacaagta tcaacaaatg aggaggaaaa acaatgacaa aacatgcaat cgctgccaag 3412081 agtctcttga aaaaatggat catttccagg ccgcttaaca tgaaaaagaa atccagccca 3412141 tttcaaaaaa tcagaaaaat gttcaaacgc ttcttcaaat aaaacatcaa atcccctaaa 3412201 tacaatccgt attcacccgt accgcccaaa tgctccgtaa tttgggtttt ttgtgttcaa 3412261 ttccgcaaaa tagggtataa accaaacaag caagaaaaca gcacccaaaa acaggtaatt 3412321 cgaattacgt aaacttaggt taaaagttat ataaaggaat ttattttatc gtcgatagta 3412381 actatagaac caatcatcaa caagagcaaa cagcgtaatt caagactatt ttcaggtcat 3412441 caggtaatac tgttttagag ggacagtttc ttgttattta ttgatttaga attttttgaa 3412501 tactttttgg cattttatcc gtacaataga gagtaccaaa actttttttg ggaggtatgt 3412561 aatatgatcc tatttattat catcgcatta tgcggctatc ttcttttttc tttcagcaag 3412621 gacaatcgcc gcaaaccgca aaagacaagc cctctgccag cagccgcacc tcatcacaac 3412681 aacctaatcg accttgacgc catccgccaa aaacgccgga tgcatctttc ctaattctat 3412741 atttcaaacg aaaaggctgc tgaatcacgc agccttttaa aattgttttg atttagagcc 3412801 tgaaaccttt tcgccaccta tccgtaattt catacaaggc aaacccaaag gagacttcag 3412861 caatgatcga gttatttatg aaacaaaaaa tgttctcatt taaagatgca tttcacattt 3412921 atgaccggga tgaacaagaa acattcaagg tggaggggcg ttttttctcg ttaggagact 3412981 cattacaaat gacagactca tctgggaaaa cgctcgtttc catagaacaa aaactaatgt 3413041 ctttattgcc gcgctatgag atttcaattg gcgggaaaac agtttgtgag gtaacgaaga 3413101 aagtaacgtt ttccaaaccg aaatttgtga tttccgggct taactgggaa atagatggtg 3413161 atttatggag ggatgaattc caactgacgg acggggaaaa tgtccggatg tcagtgagca 3413221 aaaagtggct cagttggggt gattcctatc acttgcagat tgcatacgag gaagatgttc 3413281 tgatttgcac tgccatcgct atcgtgcttg atatggtttt atataacgat gaagatgaaa 3413341 gtattttcta aaaagcattg acaattgatc caaaagtaat aatattaaga taattgaaat 3413401 ctgaatatga agttgtacct tatcaagaga ggtggaggga ctggccctat gatacccggc 3413461 aaccgctgtt tcaaacagaa tggtgctaaa tccttaagaa cattgcgttc ttgcagatga 3413521 ggcggagatt tgatcgttca agctcttcct tacacaaagg aagagctttt tacatgctta 3413581 atatttcaga aaagaggcga ataacatggc tcaacaaacg aatgttgcag gacaaaaaac 3413641 agaaaaacaa cgcaaagcac ctttccgcgc cgatcatgtc ggcagcttgc ttcgttccgt 3413701 tccggtaaag gaagcccggc aaaaaaaagc ggctggtgag atgacagcgg aacagcttcg 3413761 tgatatcgaa aatcaagaga tcacccgcat cgtggaaaaa caaaaagaaa tcggtctcga 3413821 tgtggtaaca gacggggaat tccggcgttc ctggtggcat tatgacttcc tggaagggct 3413881 tgacggtgtg gaaccgttca tcccggctga ggggattcag ttccataaca caaaaacgaa 3413941 agcgcgcagc atcaaagtga cgggaaaact cgattttacg agccacccag cgctcggtga 3414001 ttatcaattt ttacatgaga ttgccggtaa cgcgacgcca aaattgacca ttcccagtcc 3414061 aaatatgctg ttttttggcg aaaaggcgga taaagggatt tatgacgatc aagaggaata 3414121 ctttcatgat atggcccaag cgtacaaaaa agcaatcaaa gccttctatg atgctggctg 3414181 ccgttatctc cagcttgatg atacgtcatg gtctctcttc tttgaggaca aaggcagaga 3414241 ggttgtccgg gcgctcggcg gtgatccaga aacattgcca gccatatttg ccaaaacaat 3414301 taacgatgcc gtcgcagacc ggcctgacga tttaacgatc acaatgcaca tttgccgcgg 3414361 caacttccgc tcaacctggg cggcatcagg agggtacgac gctgtagcgg aaacgatttt 3414421 ggacggctta aaccttgacg gccttttctt ggaatacgat gatgaccgct ccggaaactt 3414481 tgatccgctc cgttttgtga agcgcaagga tctgcaaatt gtgctcggct tgatcacatc 3414541 gaaatacggc gagcttgaaa atcctgagga tgtgaaacgc cgtatcaatg aagccgcgcg 3414601 ttttgtcagc ttggaccagc tatgcctgag cccgcagtgc ggtttcgcct ctacagaaga 3414661 aggcaacctt ctgacagagg agcagcaatg ggcaaagctg cgccatgtca tcgacattgc 3414721 caacgatgtg tggagataat ctatcattga cagaaataga aaatgtgtga ataatagata 3414781 ctatcagaaa atttaataaa aaggttttcc ttatcaagag aggtggaggg actggccctg 3414841 cgatacccgg caaccgctgt ttaacagaat ggtgctaaat cctttagagc aatgattgct 3414901 cttgaagata aggttgagat tgtcacgcaa gctcttcctt atccaaagga agagcttttt 3414961 tatatttgaa tggaaagaag gaatggacaa catgtcacaa caaacaacac ccgcagaaca 3415021 aaaatcactt caaagaaaaa aaccgccgtt tcgcgcggat caagtcggaa gcctgctaag 3415081 atctgagccc gtcaaaaaag cgcggctgca aaaagcggcc ggcgaaatga ccgctgagca 3415141 gcttcgccaa attgaaaacg acgaaatcat ccgcattgtg gaaaaacaga aggaaaccgg 3415201 cctgaacgtc gtgacagacg gtgaattccg cagagcatgg tggcactttg atttcctgga 3415261 aaacttagat ggcgttgagc cgtttactcc tgagcaaggc attcaattcc ataacgtaca 3415321 gacaaaagca cgcggcatta aagtcacagg cgatatcgac ttttcaactc acccaatgct 3415381 tgaagattac tcatttctcc atagcattgc cggtgacgcg acgccaaaga tgacgattcc 3415441 aagtccgaat atgctgtttt tccgcggaaa actggaaaag gatgaataca aaaacgatta 3415501 tcaacttttc cagcacgatg tatccaaagc atataaaaaa gcgattcaag cgttttatga 3415561 cagaggctgc cgctacctcc agcttgatga tacagcgtgg gccgttttct tatcagaaaa 3415621 aggcttaaaa caaatcgaag cgttcggaac aacgcctgac gagcttcgcc agctgtttgc 3415681 gaaatccatt aacgacgcga ttgcagaccg cccggatgac ttgacggtaa ccatgcatat 3415741 ttgccgcggc aacttccagt ccacttggac agcggaaggc ggctatgacg cagcagccga 3415801 aaccattttt gacggcttga atcttgacgg acttttctta gagtatgatg attcacgctc 3415861 aggcggattt gagccgctcc gttacgtaaa acggtctgat cttcagcttg ttcttggctt 3415921 agtgacatct aaattcggtg agcttgaaaa tccggatgac gtgaaacgcc gtatcgaaga 3415981 agcgtcccgt tatgtaagct tagaccagct ttgcctcagc cctcaatgcg gattcgcttc 3416041 aactgaggaa ggcaacaagc tgactgaaga acagcaatgg gcgaagctcc gccatgtggt 3416101 tgagatcgct aatgatgttt ggaaataagc aaagaaaaaa acacacttga ttccctagcg 3416161 gagcaagtgt gttttttatg tcattgtgcg gtgtagcccc catcaaggac gacagcctgc 3416221 ccagtgacgc ccttcgcctt ctcgcttgcc aaaaacacgg cataatccgc aatttccttg 3416281 acggaaagca gtcgcttttg cggcacaagc ggaaaaatga cttgttcaag tacagagtcg 3416341 taagggacat ttctagtttt cgatagatcg ctaagctgat tgcgtacaag ctgggtatcg 3416401 acataacccg gacagagcgc attgactgtt atgccgtggg gcgcgccttc cagcgcccct 3416461 acttttgtga gtccaatgac gccgtgcttg gcgctattat aagcggattt ccctgcaaag 3416521 cccactaatc cattaacaga cgcaatatta atgattctgc caaactgctg ttttttcatg 3416581 atcggaaaaa catgcttcat tgcaataaag ggagccgtca gcatgacctt gatcagctgt 3416641 tcaaaggtgt ctgtcggaaa ctcttcaatc ggagcgacgt gctgaatacc ggcattgttc 3416701 accagaatat ccaagcggcc gtattgtttt tggatgacgt tcaccgtatc agcaacttgc 3416761 gcttcctttg tcacatcata cggaatggcc gccgcgtcaa agccttcttc tgcaagcttg 3416821 gaggctgctt tttcacatgc ttccggacgg aggtctgaaa cgatgacgct ggcaccttcc 3416881 cgggcgaatt ctcttgcgat ttcgaatccg attccgccgg cagcccctgt caccaaagcg 3416941 acttgttttc tcatgtcaaa caccttccca ttaagaattg agtacagact ggcttacagc 3417001 gaaatcagct tctgtttttt cataaacctc ttcaattgtg acaccatcct gaagctccgt 3417061 cagtgtcatg cggccgttca caaaatcaaa tacagccaaa tccgtaatca gcctgtgtac 3417121 gactttctgg cctgtcagcg gaagggagca tgtttttttc acctttgatt caccatgctt 3417181 attgacgtgc tccatgatga caacgattcg tttcgccccg ttgacgagat ccatggcgcc 3417241 gcccatccct tttaccattt tgcccgggat catccaattg gccaaatccc cctgctccga 3417301 aacctccatt ccgccgagaa tagctaaatc gatatgcccg cctcttatca tcgcgaatga 3417361 ctcagcgctg tcaaaataag aggcgcctgt cacttcagtg atcgtttcct ttcccgcatt 3417421 gatcaaatcc gcgtcttccg ttccttccag aggatagggg ccaattccga gcaagccgtt 3417481 ttccgactga agcatgacgt gaacgccatc gggtatctca tttgcgacaa gcgtcggcat 3417541 tccaatcccg agattcacat tcatgccgtc cttgatttct tgtacagccc gtttgaccat 3417601 tcgttttctc gcttccttca cttggcctca ccctttcccg atgcttgctg aactgttcgt 3417661 ttttcaatcc gtttttcttg gctcgcgcca agcacgacat gctgtacgta aattcccggc 3417721 gtatggatgt gatctggatc gagctctcct gcttccacga tttcttccgc ctcggcaatc 3417781 gtgatcttgc ctgccatggc ggcaatggga ttgaaatttc tcgccgtttt cctaaaaatc 3417841 aaattgccca tggtgtccgc tttccacgct ttgacgatcg ccacatcgcc ggtaatgcct 3417901 cgctccagca cataagtccg gccgccgaat gttttatgtt cttttccctc ggctatggag 3417961 gtgccgacgc ctgtcgccgt ataaaatccc ggtatgcctg caccgcctgc acgaattctc 3418021 tcagcgagcg ttccttgggg aacaagctct acctcaagct ctccgcttaa aaactgccgc 3418081 tcaaaaattt tattttcacc gacataggaa gcgatcattt tcttgatttg cttgttagcc 3418141 agaagcaaac caagccccca gtcatcgact ccgcagttat tgctgacaac ggttaaatcc 3418201 tttactccct gatctcttat agacaaaatg agctgttcag ggatgccgca cagcccaaac 3418261 cctcccgcga tcagcgtatc cccatcatga atcagtttcg cagcttcctt gcttgatgac 3418321 agcacttttc ccatattgat gcccctttcg ttttcttcta cactagacca gtcaggctgt 3418381 aaatcgcgat cacagcaaat acggcagccg ttttaatgag cgtgatcgca aaaatatcgc 3418441 gataggattg ccggtgggtc aaacccgtca cggccagaag cgtgataacg gcgccattat 3418501 gcggcagtgt atccatcccg cctgatgcca ttgaaatgac ccgatgcatc acctctggcg 3418561 gaatattgta agcctgaatc gcctgtaagt attgttctga catcgcgctt aacgcaatgc 3418621 ccattcctcc cgaagccgag ccggtgattc ccgccagcgc agttgtcgta acggcgccat 3418681 ttacaagcgg atcggtaaaa gtatgtgaaa ttccgctgct cagcttatga aaccccggca 3418741 gcgcggcgat aatgccgccg aacccgtact cagcacccgt attcatagat gccagcaagg 3418801 cgccgccaat tccttcattc agcccttcct tcaattgggc aaacacactt ctccaatcaa 3418861 ataatatcgt tgtgatgatg ccaatcacta aagcaatctc caccgaccaa atagcagccg 3418921 ctgaagaaat atcaagcctg ccgaactcct ttaatcctat ggaagaaaaa tcaaatccat 3418981 tcggatacca ctttggcagg taaatggtga aatatttatt cactgcaccg acgagaataa 3419041 gcgggacaaa ggcaagcgcg tgccgaatcg ggcttttgtc cggttcagcc gcggactcaa 3419101 tcgattcagg agcaggagca ttctgcgaat caaaaccgcc atagccttcg ccagatgcct 3419161 gcgctttctt ccgccttgat tccaaataga gcatcccagc tgccagcaca atcactgcgc 3419221 ccatcaaacc cagccaaggg gcggcataaa tgtctgtttt gaaaaacgac gtcgggatga 3419281 cattttggat ttgcggcgtt cccggaagtg cgtccatcgt aaacgtaaaa gctcctaaag 3419341 caatcgtacc cgggatgagg cgttttggta tgtttgcttc ttggaacatg tttttcgcaa 3419401 aaggatatac agcaaatacg acaacaaaca ggctgacacc gctgtacgtc aagacagcac 3419461 ccatcagcac aatggcaagt atcgctcttt ttgccccgac aagccggaca attgttttcg 3419521 cgattgatgc cgcaagcccg gccatttcaa cgacctttcc aaaaatagca ccgagcaaaa 3419581 acactgggaa atacagctta ataaaacccg ccatcttctc cataaaaatt gatgaaaaaa 3419641 aaggaagcac atggcttgga tctgtcagca gcaccgcgaa taacgcgcaa atcggcgcaa 3419701 acaatatgac agaaaatccc cgatacgccg taaacatcag caaacctaac gccaatagaa 3419761 tgatgatcag ttccacacac acatcccccg tttccgcgaa ctagaaagcg tttacaaaaa 3419821 cctgtccgca tcggctgttt ccgtcccctt tccatatgta cgagaagcgt gggccaacta 3419881 ttccgattaa aaaaggaaag ctcctttttt cggagctttc ctctaccatt catttcattc 3419941 ctattaggat atcaacatca accgtaatat cggctgattt catctctttc agcaggctga 3420001 ctcgatcttt cggcgccgac caggcaagcg gcgtcatctt gagaagccag tggatcgcct 3420061 gctggtcaag cgttttaaca tagcgcagcc tgacaggacg gctgtgtgct gcatttgctg 3420121 taaaacgctc aactgctgcc gtattggaat acgtgcgcct tggtgaatca gtatataaaa 3420181 attgccttaa ttctattaaa tagtcgcttc gcggcactac ttttatgagc atgccatcat 3420241 tcttcagcag tctatgaaac tctgcataat tggacggcga aaaaatagac agaacaacat 3420301 caaattggcg atcatgaaaa ggagcacgcg ccacatcggc aaccgcccac atcagatctt 3420361 tgaatgcctt agaagctttt aagatcccgt ccttcgaaag atctatgccg gttcctatcg 3420421 ctgctttccc tgcataatca aacccgcaaa gcgcattcaa atgagaaccc tcaccgcaac 3420481 cgctgtccaa gatggtgaat gcctcatgac cagatttggg atgactgatg agctctgcaa 3420541 tcgcatcatg gagcgggtca aaaaaaccac attctccaat cagcctgctc ctcgcttcaa 3420601 aaagctcggc accgtaactg gttttgaccg gcttcgtcag aaagttcacg tagccgtgcc 3420661 gagatagatc aaatgtatgt cctcgttctg tacaaatcaa gcttttccct gatgccgcat 3420721 ccatagaaga atcgcagagc gggcatcgaa acatgctgaa atcaactgtt cgcttcatga 3420781 taaaaaacac cccattcatt catttttaga taaatgaaaa aggcatagac aaataaacct 3420841 aggcctatct caaaaattgg ccaggtctgg cagtttgtct acacctgtca ttatctataa 3420901 cgaatgaatt ggataatcat gaaaaaaact ccctttctgc tgtatgggtt tccccgtttc 3420961 catcatacaa caaatatcca ggagctggaa ccttatagtg aagaaaaatc agtactgaca 3421021 tgctggtatc ccgccaacat catatcagca tagcaatcca gcatgttttt cctttatttt 3421081 ctcattttag aatataaatt ttattattgt gaaaatagtt aaaaaggttg attttcaaaa 3421141 agtgaaagga taaaatactg ctatcatctt agaaaaagac attcttgtat atgatcagta 3421201 atatggtctg attgtttcta cctagtaacc gtaaaaaact agactacaag aaagtttgaa 3421261 taaatttgaa cgagttgaaa aggacaagtt cttttctgtt tgctcttatt tttcacactt 3421321 tctgcacttc cagaatttgt gaaggataag agcttttttt gtttccataa taaccctcat 3421381 aggagttgct atcatgtact ttttactaaa ccttgtcggt ctcattgtga ttatggcagt 3421441 tgtattccta tgttctccgc agaaaaagaa aatcaagtgg cgcccgatca ttacgttaat 3421501 tgttctggaa ttgctgatta cttggtttat gctgggaaca aaagtcggaa gctgggccat 3421561 cggtaaaatc ggtgatttct tcacttggct gattgcttgc gccagtgacg gtatcgcgtt 3421621 tgcctttccg tcagtgatgg cgaatgaaac agtagacttt ttctttagtg cgcttcttcc 3421681 aattatcttt atcgtcacat tctttgatat tttaacgtat ttcggcattt tgccttggct 3421741 gattgataaa atcggatggg tgatttcaaa ggcttcccgc ttgccgaaat tagaaagctt 3421801 tttctctatt caaatgatgt tccttggaaa taccgaagca cttgcggtca tccgccagca 3421861 gcttacggtt ttaagcaaca accgcctgct cacattcggt ttaatgagca tgagcagcat 3421921 cagcggctcc attatcggat cttatctttc aatggtgcct gcgacatacg tgtttacagc 3421981 cattcctttg aactgcttaa acgcgctgat tatcgcaaac ctgctgaatc ctgttcacgt 3422041 gccggaggat gaagatatca tctatacacc gcctaaagaa gagaagaaag actttttctc 3422101 tacgatttct aacagtatgc ttgtcggcat gaacatggtt atcgttattt tggcaatggt 3422161 gatcggatat gtcgcattaa cgtcagcagt taatggcatt cttggcgttt tcgtacatgg 3422221 cctgaccatc cagacaattt ttgcttatct gttcagtccg ttcgcattcc tgcttggact 3422281 gccagtgcac gatgcgatgt atgttgctca gctgatgggc atgaaattag caacgaacga 3422341 gtttgttgcg atgcttgact tgaaaaacaa tctcaaatcc cttccgcctc acaccgttgc 3422401 ggtggcgacg acattcctga cgtcctttgc aaacttcagt actgtcggca tgatttacgg 3422461 cacgtacaat tcgatccttg acggagaaaa gtcaacggtc atcgggagaa acgtgtggaa 3422521 actgctcgtc agcggaattg cggtatcttt attaagtgct gcgattgtcg gcctgtttgt 3422581 gtggtagaaa cattgagcca tatccctttt cggatatggc tcttttcatt attgataaat 3422641 agaggctggc acctgcacat cccggattcc cgctgcataa ggccccaagt catactggcc 3422701 gaagacgatg gcgatcccgt ttgccgtaaa gtaaaacatt gtgtctctgt ttagggttat 3422761 atcctctttc tttacatcag agaaaaacag cacatcgtgt tttttgatat agctatatag 3422821 gtaatctctc gttttgctga cttttgtttt ggtgttcaga atctgatcca gcgtcacccg 3422881 cttttgtgct ttcaagtcat agttgaagga ctggacagac gttagaccgt gggcgccccc 3422941 tgaatagata taattgagtg tttgaatgct gagcttgcct gccgcattgt atttgacgct 3423001 gaaggatgtt tgatattccc gttttaaagc cctgctgttc gcctgctttt ttgtttttca 3423061 ggtattcctg atacgattgt tcatgtaggc tttcagctct tgattgattt tcttttcaaa 3423121 cgcggcattc ccgacgtgat gcacttgtgg atacgttaac tccttgatct ttttgtacgt 3423181 atgggtgctg acagtcggtg ttttcgcttg aactgctttt aaagatgggg ccgcatatgc 3423241 aaatacagaa aaaagcaaga ctgcaatgcc cgcggctttc agcatgttat tccatttcat 3423301 acaatctact cctttgatgt cgttgtttat cattccctta tttaagcaat acacactttt 3423361 atagactgat taaatcgaaa gaagtttcta ggtctaacag catgattttt ccaataaaaa 3423421 aagagacaca ggatgtctct ttttttactg tttgcgccca gaaatcgctt catgaagggc 3423481 ttgtgccaaa tctgtatttc cgaacatctc taataccgca atgacagtct ggtccggaat 3423541 gtgctctgct tcgtgttttg gcacgaccag atcgtccatg gtttttttca agctttcatt 3423601 cagcttttgc tgcggatacg ctttggcgta cagctccatc ggatcaagat catggttcac 3423661 gcaccactgg gcaaacacca aaatcatcat attttcatcg cgttcgtaag cttcagtgag 3423721 ctgtttttcg ttcatttgtc atgctcctta tgaaaagtat cttccttaaa gatacaggag 3423781 ccgatcaaat tcgtctatcc caatggcgat gagcagcaac cgcatcgata aatgccttgc 3423841 tgaaagcggt gtagtcaggt tcatctttag ccgttacgat gcctagcccc tctgttgtcc 3423901 cgacagagga ttgaagaagg tcaattcctt catttgccgc accgatcgcc ttgtagtgat 3423961 tgtaagcttc tctgataaac gccatcgctt gtttgttgtc ttttaactcc agtcctcctg 3424021 cggcatagac ggcatcatac agaacagaat caaccgtcag gaacgtgccg ctggcctcaa 3424081 gctgctgtcc gctgccgctt gtcatatacc ccagattttg actgatgata tccactgtga 3424141 ttccttcttg ctttaaggct tccagtactg tttgcagctc tttttcatga aatccgtttc 3424201 cggcgagtac agcgactttt cttgttgacg cggttttcac tgtacgggct tggcttaacg 3424261 caggcgaagt aagaatttct ttagatgctt tacgcttcgc gggcgccgcc acgcctactc 3424321 ctttggcgat ttcttctgct aaatctgcat cgacattgct gaagacatca acgacctgcc 3424381 gctgtacgtc tttgcttttg accttcccga cctcgaagca gaaagcagaa atgatgtgct 3424441 gtttctccac aggagacatg ctgttccaga aaagcttcgc ctgtgagtaa taatcgttga 3424501 agctgtcgct tcgctggcgg atttttttgc cctcgacttt ttcctgatag tggacgtagc 3424561 cgccttcttc agctgtcgca ggcgacggat cattgttttg cagtgagttt ttatgataag 3424621 cgacaggtcc cttattgatc gtcatccggt gatagccgtc gtattggttg ttatggaatg 3424681 gacagaccgg ccggttaatc ggaatctcat ggaagttcgg gccgccaaga cggatgagct 3424741 gtgtatccgt ataagagaaa agccgcccct gcaatagcgg gtcattggta aaatcgatgc 3424801 ccggcacgac atttcccggg tggaatgcga cttgttctgt ttccgcaaac acattatcct 3424861 gattgcggtt cagcgtcatt tttccaatga tcttcaccgg cacaagctct tccggccaca 3424921 gcttagttgg gtcaagaata tcaaaatcaa acttgaattc atcttcctca tcaatcatct 3424981 gcacgccgag ctcgtattca accttgccgc cgttttcaat tgtttcccac aggtcacggc 3425041 ggtggaaatc tggatctttc ccggcaattt tttgcgcttc atcccatacg agagaatgca 3425101 cgccgagcac cggcttccag tgaaatttca cgaaacgtgc ctttccttgt tcattgacaa 3425161 aacggaacgt gtgaacgccg aagccttcca tcattctgta gctgcgcggg atgcctctgt 3425221 cagacatcgt ccacatcacc atgtgggcag actcagggtt attggcgaca aaatcccaaa 3425281 atgtatcgtg agcagtcgca gcctgaggca tttcattgtg tggctcaggc ttaaacgcgt 3425341 gaaccaaatc cggaaatttg attgcgtcct gaatgaaaaa caccggaatg ttatttccca 3425401 caaggtcata gtttccttct tcagtataaa attttgtcgc aaagcctctg gcatcccgca 3425461 ccgtgtctgc ggagccttta gaacccgcaa ccgtagaaaa acggacaaat accggtgtct 3425521 tcaccgaagg gtcctgaaga aatttggccc gtgtgtattc cgtcattggt tcgtaaacct 3425581 gaaaaaagcc atgcacgcca aatccgcgcg catgcacaac gcgctccgga atcctctcat 3425641 ggtcaaagtg cgtcattttc tcccggaaat gaaaatcctc catcagcgtc gggccgcgaa 3425701 ccccggcttt taacgagtgc tcatcctctg acactcgcaa gccttggttt gtcgtcattt 3425761 tcttcccgct gttatcggtc ctgtactgct caagctgctc gtcctttgag tgttcattta 3425821 cacgtttgtt ttggtcatca ctcatgtctg ctcccccttt ttaaaacgaa acattctaca 3425881 gcacatttac ccgtggcgtt cttcatataa actgctaatc cgctcattag gatttttggt 3425941 ctacatataa atatgcggtc atacacattt gaaataagcc ttcttcacag aaagaaagga 3426001 tggaagcgct taccaaaaaa gctgttgaat aggggaggtc atatcatgct tgccatactc 3426061 ggttttgtga tgatgattgt ctttatgtac cttattatgt ctaaccggct ttccgctctt 3426121 attgctttga ttgtcgttcc tattgtgttt gccctgatca gcggatttgg caaagatctc 3426181 ggcgagatga tgattcaggg cgttacagac ctcgccccta ccggtatcat gctgttattc 3426241 gccatcctgt atttcggcat tatgattgac tcaggcctgt ttgatcctct cattgccaaa 3426301 atcttatcgt ttgtcaaagg agatccgtta aaaatcgccg taggcacagc ggttctgacc 3426361 atgaccattt cgctggacgg agatgggaca acaacctata tgattaccat tgcagcgatg 3426421 ctgcctctct acaaacggct cggcatgaac cgtttggtgt tagcgggaat agcgatgctt 3426481 ggttcggggg ttatgaatat tatcccgtgg ggcgggccga ctgcgagggt tttggcttcc 3426541 ttaaaattgg acacgtcaga ggtctttaca ccgctgattc ccgctatgat cgccggcatt 3426601 ctctgggtga tcgccgttgc ttatatcctc ggaaagaaag agcggaagcg gctcggcgtc 3426661 atttcgattg atcacgcacc gtcttccgac ccggaggccg caccgctcaa gcgtcccgct 3426721 cttcaatggt ttaacctgct gctgactgtc gctctgatgg ccgcactgat caccagcctg 3426781 ctgccgctcc ctgttctttt tatgactgcg ttcgccgttg ccttgatggt taactatcca 3426841 aatgtcaaag agcagcagaa acgaatctcg gcgcatgcgg gtaatgcgtt aaacgttgtc 3426901 tcaatggtgt ttgctgcggg catattcaca ggcattctct ccggcacaaa aatggtggat 3426961 gccatggcgc attctctcgt ttcactcatc cctgatgcca tgggcccgca cctgccgttg 3427021 atcactgcga tcgtcagcat gcccttcacc tttttcatgt cgaatgacgc cttttacttc 3427081 ggtgtccttc ccatcatcgc cgaagccgct tccgcttacg gaatagacgc cgctgaaatc 3427141 gggagggcct ccttgctggg gcagcctgtg catctgctca gcccgcttgt gccttccacc 3427201 tatctattgg taggaatggc aggcgtcagc tttggcgacc atcaaaaatt cactattaaa 3427261 tgggccgtgg gaacaacgat tgtgatgacc attgcggcgc ttttgattgg gattatttct 3427321 ttctaaatgt atgagcttga tcgtagcatt gagtgagtac gtgatttaca gaggggagaa 3427381 gatcaaatag gatattatga gtgaatagaa gattcatgcc aacaacttct cattacaatc 3427441 ataagagcct gctatattgc agcaggctct ttcacatttg gcattatttt tttgtatagc 3427501 gcacccagtc ataatgagcg tatagcggat ttacaccatt gtaggagcca agccattcat 3427561 cgacacccgt gccattccac aagttcatca tgatctttcc aggtgttgtc ggaatttggt 3427621 ttgttgcagt atgttttaat tgcccgtcga cataccattt aatagagttt ggctgccaat 3427681 cgaatgcata cgtatgatag gcattggctg catcaaaccc gagatcaaca atcttctcat 3427741 ggtttcctgc accatttgta taatagttaa attgaacctt cgttgtgtct tttcctaaaa 3427801 attcgatatc aatctcatcc caaggagttc catctgttgg acctgtgtaa gtgaagaacg 3427861 atgaaacgat ccctgtgttt ttagctggtt tcattctgac ttcataaagt ccatagccat 3427921 atgtttgaac agaacggttt tccccgcagt caaacttgtt ataagctggg cttgttagcg 3427981 ctaaacgcat ttcacccaat gacgtcattg atacgttatt agcccgccac gtgcagttga 3428041 acatatttcc attcgaataa ccatctgctt tttgccaaaa accggagtta tagccgttaa 3428101 aagggtcaaa aaacgatcca cctgtttgag ctgaggcagt agcagtgact gcaaacaaac 3428161 tcataaacaa tccagtgaca agaagcagca acactcgttt cagataaggc atattggcat 3428221 tcccctttca ttgaaagcgt tttctatgtt gatcttacat gattctttta aaagggaaca 3428281 tcggtcaaaa taatgataat atcgaatctt actaacttga atcctgtaac tatcatcatc 3428341 ttccctctga aaaaaataaa aacctaaatt accatcagca cagacagaga tgatccgcac 3428401 tcattgcaat ttaggttttg cctgctttat cagtaacaat cctaccattt tcatatgtga 3428461 atgtaagaaa aagtgaacac aaggaaacac aaatgtcagc gctctcatta tgcttgttta 3428521 actacccttt ctatgtgaat ggttaaatac agcagctcgt cacttgtgag cttgtgctca 3428581 tactcccgct caatgtaggt ttggattttc ttcgtgcatt catacgcgcg atgatacttt 3428641 tctttcactg tatccagcaa aaaatcgtcc tggctttcca tgtgagtgcc gttaaataga 3428701 cgctgcgcga aaaactttaa gtgggtgacg aaccgataat agtgaagcga ttcttcgttg 3428761 aattcaatct taaaatggta ttttacaata ctcaaaatct cttgcatgac ttttgtaatg 3428821 ttgataatat tgggcatctc ttcattcagc tcggcattta caatatgcag agcaataaag 3428881 cctgcttcat cctctggcag agacacacca gtcttgtttt ttaccataac caacgcttct 3428941 ttgccgatcg caaattcgtc tttgtagagc cgttttgttt cccacagcaa ggcgtttttg 3429001 atatcaagcc ctttctggtt gcgctggatg gcaaagttaa tatggtcggt cagcgacaca 3429061 tagatgctgt cgttgagctt tttgccgagc tgtaattttg cgtagctgat aatctcttcg 3429121 gatacttcca tacactcgat cggtatatca tacaaaaggg ttttgaactt ttctgataca 3429181 tccttgttat cgagcgtgaa cactttctca atgcgggctt catcgacatc atcgccggac 3429241 tttttctgaa acgcgagccc cctgcccatg acgaccaatt ctttcccctg ttcattgacc 3429301 acgctgatca cattattgtt gatcaccttc gcaattttca tggcatgtcc ctccaaatct 3429361 actaagaaca gactatatct tgattgtaca ttctttttgt actaggtcaa tatcatcagg 3429421 gaaagacgga agctggtcag tacaattcac tccgtacctg ctgcccgggc tgtttttgaa 3429481 gcagcgcctc cagatggcgt tcaaatgatg ccttgtcagc tttctgcttt ttgacaatgc 3429541 tgttcatgat tttaatgctt tcagcactgt attgtgtata ttgttttttc agctgatcca 3429601 gctgctgtct tgtcttcttc gcgtttttcg gtgtgacttg gttgatgagt ttgatcatac 3429661 tgtctgcggt ctcaaaaaaa ccggctctat tttctgtcag ctgctgaatt tcgatgcggc 3429721 tcatatcttg attacgcgtt ttttgaagca aggcaaccgc ctcgctgttt tgttttttga 3429781 gcgatttgtt ctcaagctta atcgattcga gattctcctt cgcaatgtct gcttcttctt 3429841 cagtcatgct gattcgcacg aagtattctg gattgccgat tccataatca aatgcttcgc 3429901 tcacttgtat catggaactg aacacaatgg ccagctgcct gtcgcttgcg agggcttgga 3429961 aatcctgctt tttcttactg ctcatcggtt tggctgcggt ttgttttact gtcttttgat 3430021 cacagtctgc gaacatctga gcctcacctt cactttcgca tgcgctcatc acaagaactg 3430081 tgaccagcag gcttatacac aagcctattc gcctcatgct ctgtctcctc tctgctgaat 3430141 cccttctgga aaataccata aaatatagtt aaatggtacc agatgcacct aaccccagca 3430201 ataaatcaaa agtatgattt gaagcgaaaa aacataaata ttttgtaaaa attgacgtgc 3430261 attccattct tttcaggccc atttctcgta caatagaagt atcgttaccg gagaggggct 3430321 ctgatgatga aacgttttac gaaacaagaa aacagctggg tgttatatga ctgggcaaat 3430381 tcagcttact caattgtcgt gaccaccgcg gtatttccgt tattttataa atcagcagct 3430441 gcggaaagcg gtgtcagcgc cgctcaatcg actgcctatc tgggctatac cattgcgatt 3430501 tcaacgttta ttcttgcgat gctcggccct attttaggca caatcgccga ctatgaaggg 3430561 tgcaagaaaa agttcttcgg tttctttgtg tcagccggtg tcgccagcac cgcgatgctc 3430621 gcctttatcc ctagtgaaca ttggctgcta ttgttgctgt tttatacggt atcggctatc 3430681 ggtttttccg gcgccaatgt gttttatgat gcctttctcg tggacgtcac gcctgagaag 3430741 cggatgaatc tcgtctcggc acggggtttt ggcttaggat acattggaag cacgattcca 3430801 tttatcatca gtattgctgt catcctgctc gcacaagcag agactattcc agtgtctgta 3430861 tcggccgcaa gccagctgtc cttcttcata acggctgcct ggtgggggct gttcaccatc 3430921 ccaatgatta aacatgtcca tcaacgctat tacatcaaaa aagaacctca tattgtcatc 3430981 aacagcttta agcggctcgg ccaaacgatg aaacggatca ggcaataccg ggcacttttc 3431041 ctcttcttgc tcgcttattt cttttatatc gacggagtcg gcacgattat tacgatgtcg 3431101 acatcctatg gatcagattt agggatcggc tcctcaagcc ttctgatcat cctatttgtc 3431161 acccaggtag tcgccgcgcc gttttcgatt atatacggaa aactggcaga acgcttcacg 3431221 gggaagacca tgctgtacgt cgggatcgtc atttatatga tcgtctgcgt gtatgcctat 3431281 tttatggaga caacgcttga tttctggata ctggctatgc ttgtcgccac ctcgcaaggc 3431341 ggtattcaag ccctaagccg ttcctatttc gccaagcttg tgccaaagcg ccacgccaat 3431401 gaattctttg gcttctacaa catttttgga aaattcgcct caattatggg gccgctgctc 3431461 attgccgtta ccgcccagct gaccggtaaa tcctcgactg cggtgttcag cctgatcatt 3431521 ttgtttgtga ttggtattgt gattcttgcc tttgttcccg aggaaaccag cacagatgtc 3431581 agccagcagc aaaatgacct gcccctttaa ctgggagcag gtcattcatc atttattcgc 3431641 tttattcacc ttcagctgtt tccctttgac ggttgtgttc ttcatcactt tgagaacatg 3431701 agggccttta ccatttaaaa tctcaacgta tgaggcgtta tccatgatcg tgatgatgcc 3431761 gatgtcgtca gctgacacac cgtcaatttt ggcaatcgtt cctacaaaat caacggctct 3431821 gattttcttt ttctttccgc cgttaaaata cagcttcata atgtctttat tcagctcttc 3431881 gcttttgtcc tttttgcttt ccggacggtc attcagttta gctagaaatt ctggtttctt 3431941 ccttgccact tcctcttgag aaggtgcttc tattttttgg atttcaaatc cgatatattc 3432001 ttcaatgtcg gctaaaaacc gtttttcgaa ggccgtgaca aacgaaatgg cctttccttt 3432061 gttccctgcg cgtcccgttc ggcccgtgcg gtggacatag ctttcttttt caagcggcag 3432121 atcatagttg atgacaaggg agatattttc aatatcaatc ccgcgcgcgg cgacatccgt 3432181 cgccactaag taacggtact cgccacgttt aaattcattc atgacgtcga atcggtcttc 3432241 ctgaatcatt ccgccgtgaa ttttatcgca tggatatccc aagtcatcca attcatcggt 3432301 cagctgattg acgtgctcct tcgttcggca gaaaatgatg cagctgtcgg gattctccgt 3432361 catcagcaca tctttcagca atgaaaactt attctcttct cttacttgaa tcaccgcatg 3432421 ttcaatattt cttgtggtta ggccggccgc tttgacctcg atatgctcgg ggttttgcat 3432481 atattgacgg ctcagcttct cgatatcctg cggaagcgtc gctgaaaaca gcatcgtcgt 3432541 acgctcagtc ggcagatgct tgataatcgc ctccacctgc tcaatgaagc ccatattcag 3432601 catctcatcc gcttcatcaa tgaccaaata agagagacga tccaacggca gcgtgccttt 3432661 ttcgatatga tccagaacac gtcccggcgt gccgacaaca atgtggcttt tttgcttaag 3432721 ctcagctttt tgtttatcaa aggaggattt tccaaatacg gctgtcgctt tgatccgttt 3432781 aaatcgtccg atgttcgtga tatcttcctt tacttgcacc gcaagctcac gggtcggtgt 3432841 taaaataagc gcctgcggct tgttttcatc ccaattcgcc agctcacaga gaggaatccc 3432901 gaacgaagcc gttttcccgc ttcctgtctg tgatttgacg acaagatcct ttcgttcaag 3432961 ggcagcgggg atcacactct gctgcacctt ggtcggttct gtatatccca gtccttccaa 3433021 tgctcgtaaa atgtcatgac tgatttgata gtttttaaaa tgactcatgt ataaactcct 3433081 gtctcttgca gatgttctca ttatactcta attgaccaag gcatatgtgt tttgtcgaaa 3433141 aatgatgtat taaaagccag cgattccctg gcgttttagc tcctgaacag ccaatcgcgc 3433201 cagtgcgtcg gcccccgcgc gattcgggtg cagcgtatct ccatccatat aaagcccgag 3433261 tgttctttcc ggaccgatcg atgtaaagta tgccgagctg aggacattta agtcaatgag 3433321 atatgttttt tcctcttcgg ccaaagctaa aatagaggcc ctgtaccatc tgtttacaga 3433381 cgaatggatg ccttcagaag taaaatcggt tgcccggccc tgaggcgttg ataggatgac 3433441 gtccgctcct ttcgctttta cctgacgaat catatcacgc atcacctctt taaactccgc 3433501 ttcagattct ttatgcttcg gatttgtgtc attaatgcca agctgcaaca taaaataatc 3433561 tccgggttta atatacttca gaatcgcctc aagctgtcca tcatttctga accctctcgc 3433621 gatctgcccg ccagacgcca tgtttctcac ttgaaaggtg tgtttatcga tatagtgagg 3433681 cagcatctgc ccccagcccg cctgcttgct gctgttgagc ggataataat tgcacaccgt 3433741 cgagtcgccg ccgacataaa tggttcgatt cgttaccggc tgatcagaca atttctttat 3433801 tttcaaggcg ctgagcgtaa aagcggtgcc tgcctttccc tctgtcacca gcagattcag 3433861 ctgcccgtcg gtgacgggaa tttggaacgt atcctccgcg ccatcccctg tcatattgat 3433921 gacctgaaac acgccctccg ctgccacact ggcccttgcc gtattgccaa gcgtcacctt 3433981 cacctcataa aggccattcg ggagatcaac attaaacgtg ttattgcttt tcgtcccata 3434041 cgctaaaaac tgaaccgcat cactcttcac accagccccg gatgccgcca catccctcat 3434101 attctccggt gtttgaaaac cgtagccctt tgaccggtca taccgatcag acgccctgac 3434161 accaatataa ccaggctcca tcgaaccgct tccaaagtca aactgataca ccttcggctc 3434221 cgccgccttc acattctcaa tcccgccaaa acacagcatc agcatcatca caaaaaccgc 3434281 tgccatccat tttttcatca agactccccc tctatgaaaa cgaatacatt aatgcatact 3434341 cggtgattgt ttctttatga tgactgaatt aagaaaaaaa ttgcgttgag gaataaaaat 3434401 gaggggagag tctcaagaag gggaaaatca gtgtgacttc ttgtcacact tgatcacatc 3434461 ccaacctccg caatagaagc ttatttggtt ttcttcgtca tacacataat aacggagtct 3434521 ttcccattga tcgtcagtcg gtacaatctc caatgcaacc gaatcgatgg attcaaggtc 3434581 atccagcttt gatgcactaa tgttttcaaa ccgcaattga atgtcacagg tttgagcaga 3434641 tcgttttcat tcaaacacag gaatatgaat ataacgatca tcttctttca tatagaaaga 3434701 aaactcgttt aatgtaaatg gacctgtatc ctcatcagaa agatgctgtt tcaatttctc 3434761 gtattgtgtg atattcaaat gaattccctc tatttatatg attcaccgcc aatcatataa 3434821 atgtccacag catcgtattc aaaccatatg atccgttcgc ctgagtccgt taggcattgg 3434881 agcttccctt ctgaaaaata gcttttatcc ggttgaggat cagtgatcag aaaaacatca 3434941 tcattgatgg aagctagcag aaagagaaaa tctgcaatat cccggtctgc ttcctgtaat 3435001 atggattgga aatggaattc ccttttggcc agcttcgtca ccttgtaagc atgaccttca 3435061 aaatactcgg acaggtcttc tataaatgaa ccagtcgtta ttacctgtat catgattcga 3435121 tcgtaggcaa gccctgccca aaaacgataa aacgactctg catcttcaag ttcgcatgcc 3435181 ataacggttt ggtcaggctt aagctcgatc atgtccaaat tgccaatact gcttatagag 3435241 gttatttcca taaaatcttc cccttatcag ttggatagcg caacgcaaat ctcttgtctg 3435301 acttgttcat acaagagaat gtgatgatac agatccttat cgtttttgat catatccgga 3435361 agtatgtcag gatacagctc aaaaaagctt ttctccaacg aacgccgctg atgccggggt 3435421 atccttttat tcgccagcac ataatccaaa ctgccagcaa caagcataaa aaactcatag 3435481 atttccgctt caaagccgta caattcatca gggtactgct tttcttcaag ctctcgctgt 3435541 ctttttctca gtttttgaag cacgttgatc ctctcccttc cgcaataatc tcatttattt 3435601 cgaaacagaa taggcggatc attatctatc gcctccaaca gctcttcacc aaacacagtg 3435661 attgcacatt tccacgggtc tcccaaaagt ccccaggaga agtcctgatg aaaaaagaaa 3435721 taatagtctc catttggaaa tacgggaaca ggccattcgc caaattcatc cttaggcatt 3435781 gcctgatgag gactaaaggt atatccgtca tgctgccaat ctagtgcgta cattacatcg 3435841 ttctttccag tacctaattg aaatgctttt aaaatagaag tctctaaatc acttagcact 3435901 ccgctcacat cattatgacc agctttactg ctcatcgcgc ttgagatatc aaacactcga 3435961 tatggatcag gcgggatgat gtgatgacat ctgcttccgg gcttccattt tatgatcttg 3436021 ttcacttctg accagatgcg gtcttgtttt gtctgactta aagcgcgcca attcatcata 3436081 atctcatccc tacaccttat tggatatcct gcttataaac accagaagag gccactgcgt 3436141 aaacagcgta acttgtcagt ttcagctgtt gaacatctag gccttcaccg ttcgaatcac 3436201 agcatgttat ctcttccatc tcttgactca catcggcaga aatcaaataa agagacgact 3436261 taaggtctgc actgtaacaa ttgaacgtcc caaccaaaaa accttcttcg gatatcgcga 3436321 gctgatcaaa tgcttctgag tccggctctt tatccgacag aatccacacc cgtctcacga 3436381 ccgtttcatc aaatgcggca atgactgcat ctccgtaata cagcatataa atcaagccgt 3436441 ttttttctgc aagtccataa caatcatcta cagcaggcgc atccatttct tcaagctttc 3436501 tatcaatgtg tatttccttc tgctgaccat ctaacgtaaa acaccacaca ctatggccgt 3436561 tgggattctc atcatgataa atcccttcat cacataaacc gacccaaagc tgttgtttct 3436621 aatccaaaag acagcaggaa acccctgaag gcaagtgaaa aacacttttc acccttccct 3436681 cttctgaaaa aacctttacc ttcggctcgt acgattcgta ataaacgaag acatagccat 3436741 ctgcacattg ttgaaagagc agaatatcac tgtatgaaat ctgctctttc actctaaaat 3436801 cccgaacatc accggaagga tcatagattg taatggtgat accacctttc aacccttttc 3436861 caatgtagac acgcccctgt ggatcagcat ggaaaaaaca atcttgggtg ttctcgttga 3436921 tgattttatt caattttaat tttttcattg gttatgctcc taggttcgaa atgaaatgat 3436981 aagaataaac catttattag ctattagtaa cggacaacct agtttcatta atcgttttgg 3437041 gataaatcta ctttccaatt cagccttaaa tcatttagtg tttaattggt atgcataaaa 3437101 cgattgatca tcaaagcgaa ctgtttcagc ttctatagca atcagcattc tgttcatgtc 3437161 aataagaaag ttagcatttg attgatactc cggaattata gaatttgata gattcccgat 3437221 tccttctgga tgataactca tctcaaatac ttgccaattg tattcttccg gatctatttt 3437281 ttccaatctc atgtcgccaa catctgcact ataataagcg gatgccacat tttgaaatga 3437341 aattttatgc gtatattcac cttcatcttc aaaaacctta atatcaagtg agagttcttt 3437401 tttaaacaca ttaaaatcta aatgaaggac actgcacccc ttatctatat aatcaaccca 3437461 ttcattaatc gtttgataca ttgtcatccc ctgcctcttt ttaaacaata acgccttgcc 3437521 accaagcaga aaacaaatta ctccgtatat tgtttgatcc aatcatttaa atcatctgtt 3437581 gaatgcaaat aagtttctga tgaatctttc aaatcaatcc cacttagaag gattaacata 3437641 tcccagactc tatcgtcttc tacttcgggg tcatccgcat aaacataagt tccagcccaa 3437701 tccgacactt cttctcttgt tgtttgtcca tttaagacac ttttgatttt atttatgcat 3437761 tctattagat ttgtctcgct caatttgatc accacgtatt caagtactaa atgatttttt 3437821 attagtatgc aaagcaccgt actgatattt agatattgaa gctttttccg taaaagatat 3437881 gttccaaaag gtttccaatc taccaataaa caagctcaca tccgtattcc gtgtgcaata 3437941 tacataaacc aaactggcac ttaggctcaa ccaaaataaa actatgattg agaatccctt 3438001 catcgaactc aatacactcc aataagcagt caaggtgctc gagacatttt ccaaaagaac 3438061 aaactaacgc accaatttcg ctgctgtatt gatgaaacag cagaacgtcc cggtcatcgt 3438121 aagcaacata tgactgagat attttccaga tcagctgttt cgcttccgtt ttttcgaggg 3438181 catcaacctc acgggtgttg gctggtattg aatttgataa aaccagctca agcaattgcc 3438241 tgctttgcgc cagatcagca aaacgataag tgaagcctct ttctgcacaa gggactagtt 3438301 tttctttgat ttcgctcatc aataaacgtc ttttattctc ggcgagtttt tcgatcaatc 3438361 ttttttgcat gagccgcatt ccctccgctg tcaatttctc aacttctttt aaattgattc 3438421 atcattctct tgttttcgtt gtcgttcatg tttagatttg ttctaaaaaa gcttgtatcg 3438481 cttatcgata caagctttat cttcaactgc ttaaaactca cccagtgggc ttttcacaaa 3438541 acgctgggaa cctttttggc aaatcctctt catcccaatc aattctatat ttttagattc 3438601 ttttgtcata caaataagag aggatggtaa catctcttat ttaatgttcc atcaataaat 3438661 gccccatttt tatccaatgc agaaattatt tataattaag gaagtttaga aggatttttt 3438721 gtattttcaa gatttaattt taaagcggtc acaaaagact ctagcttttc ttcattacaa 3438781 ttaatttcga acaagttgga gttcgactta ctttctttat aatcatcaaa tataatttta 3438841 atcttaattc tgtaatttcc gttttcttga tcaatactaa gaaataagaa tggttcaata 3438901 gtctctaaac tgatactgtc ttgatttcct tttatcatag tttcgatccc agatatcaac 3438961 accttatatt cactttctaa taaaacagca gaaaaatcgc gaacgacggc tttcttattt 3439021 tccaacaatt caaatacaga taaaataaat ggatcatcgt ccaactcttg ataccttctc 3439081 ggtgttaatt caagttctat acaatcatct tttattttgg ccatatttcc tcctcattta 3439141 aagtttaagt gagggtagtt gtcatccccc cctcgcttaa ccttattaac gccttctctt 3439201 agatttattt ccttttccgt gtgtatggaa tacgtgttta gaacccttag ctcttgaact 3439261 tccataagct gtgattactt tacccctttt atttaaaaca actgtagctt tttttccaac 3439321 atatttcgtt gccccattag gttgttttat tactttttta gggcttcgca cagcattcag 3439381 tttggccctt aaattgactc cacggcctcc atttcttcct atagattgat taagtccatg 3439441 tcttgtatga cctgtgattt taactgcctt cttcgtaaac ttataggcgc gactagcacc 3439501 cttaaatatc ttcccaggac caaaattaga agcagctgcc caagcagcac ctttccatcc 3439561 tttacctgat ttatatgcct tatatccatc ataggctgca aatccggcat ttaccacaag 3439621 ccatacccaa tgcccgtccg gatcaacatt catcactggg ttattatttc cataagcata 3439681 cccattctga tccaatgaat ctccgtcgct gcccgggtct gggtcgagcg ataggaacac 3439741 gccgtttctt ggctcgtagt agcgggccat gagatagtac aggccggttt cttcgtcgta 3439801 ttggtagcct gcgtagcggt agcgattgtc ttttacttcg tcgcttgctt cggtttttgt 3439861 tggatttccc catgcgtcgt attgatactt ggcaacggtt tttccagtgc tgtctgagat 3439921 cgcgatgatg tcgccgtgag cgttgtagtg atagaaatat ttcttaccat tttctgtgta 3439981 ggataacagc tggccgctgt ctccgtacgt gtatgatttt gtgacgttgt tgtccgcgtc 3440041 tgtttcatac aagacgttca agctgtctcc gtcgtagaag tagttcgtga cttttccgtt 3440101 gacggttttt tggattctgt ttcctttttc gtcatactta tatgttgcga atggcttgtc 3440161 ttcgcctttt ttggtaacgg cggtcaggtt atcttctgca tcccacgtat atgtgaattt 3440221 gccgtcggat gtgcggttgc cgtttttatc gtaagagatg ctttcatcat tgacttttgt 3440281 cagctggttc atgatgttga aggaagcgtt caccgttttg cttgagccgt cttttatagt 3440341 tgtaacggtt ttccggtttc cgaatccatc atatgtgtat tcaataacag taccgtcttc 3440401 atgggtttct ttgacaagct gattcagctt cccatactca tattgcacct tgccgcttgc 3440461 tgagctgttt atcgttgtgc ggttgccgtt ggcatcatat tcatagcttt ccgtcagaat 3440521 gtctccgccg tttttgtcac cgatatgcag cgagcttaca aggtttcttt cgtcatatga 3440581 aaaacttgtt ccgccgccgt tgcccgtaat aaaggtttgg acgtttccat tttcatcata 3440641 atcaaatgaa tatgaggatg tactgtcttt catctcaatc atttgatcca gcttgttata 3440701 cgtaaattga ttcgttcctt tttggtcccc atgaatccac gagaaggttt tcagcttatc 3440761 ggagtcacta ggatatgtcc aagtttggct gccgccgcgg tctgtcagtt cggttaaacg 3440821 gtttttgttg tcaaatgtcc gtttctttgt ggtgttctgc tctttattga cgaccgacgt 3440881 ttcatttcca tttttgtcat acgtgaaaat gtacttttct gtaccgttat acgactttga 3440941 tttcacccgg tctgttccat cataagaaag agacacttcg ttgccatttg gtgaaatggt 3441001 tttggtcagg ttgctgttgg catcatattc gcttgctaac acattgccga gagggtcagt 3441061 tgttttgaca agcttgccca tgacatcata ttcgaattta taggtttgat ctgctcctgc 3441121 ccggatggtt ttgcttacct cattgccttc cttatcatag ctgtgaagga tagacgtgcc 3441181 gttagagagc gtcatgtttg tcaattggtc tgcctgatca tacgtatagg ttgttttttc 3441241 accttttgca tctgtttcag acgttttctt accagtttca tcgtaatcag ttgaagtggc 3441301 gtaacctagt tcgtcctctt ccttggtcac atagttgcca ttactgtcat acgtgctttt 3441361 agtcagaagg cttccttcaa tcaaacggat atcatcaaac cagactgtgc ctgtcgcact 3441421 cttttggaac agaatactga tatcgacttt attgatcggc tttgttttag ggatgacgac 3441481 agctgctcgg ttccattcct gtgttccaga agggaatttc gcattgtaga tgcctgtgct 3441541 gccgtcagcg taagtgacat tcgcctgcag agaatagtct ttttcatctg taaatttgac 3441601 gctgcttgct ttcgacattc ctgtcagtgt gagataaacc ggtttgtcat ttgcgctttg 3441661 ccctaagaca acggtttgtt ttgttactga tccggcttgg gacgcactgg tccgggcagc 3441721 ttttaatgat acatcatcat taaagccttc ttcagaatca acggatgctc cgcttacatt 3441781 ccagttttcc gttgctgatg tgaagctgct gttttgaact gggttatagc ttgatgatac 3441841 ttcgcctttt tccagctgga cttcatcaaa ccatgctttt cctttgccat ctttatcttt 3441901 atgatcgact tccatataca caacagcttt gcctgcattc gctggagtcg taaaagtgat 3441961 ttgccgtttt gtccagtcat tttttccggc taatgcactg tattcattgt gaatccattg 3442021 aattcgtttt tgatctttgt ctcgcaaatc aatgttaaaa taggctcttg atttcgcaag 3442081 atctgttttg attttcccgc ttaatgtata ggttgtattc ggctccagct caactgtttg 3442141 tgttgctgac gaatacccat gatctgttcc ggcagacgtt gattggctca agacctccaa 3442201 tgcctttgat ccggaaagaa ctccgctttt atcggcgatg actgaaattt tgccgctgtc 3442261 tttagaggca gtcagattcc agccggattt ttgagcttca aagcttccat ctttcaaaat 3442321 attagttgaa gctgataaat ctttgctcga ttgaatctgg tttccatatt tatcataaac 3442381 agctgctgac gatgattttc cgctctgatc ggtttcggat acagcatcca gtccgtcata 3442441 agcaatatcc gtgacattgc cctcggtatc cttcatcttt gtgacatcgt tgtttttgtt 3442501 gtattcgtat gtctcagttc catatgcatc tttaaccgac gtaacgttgc catctttgtc 3442561 atattgatag ctttccgttg cttttccggt gccgacgtca tttggatcta catcttctac 3442621 aacattgttg ccttcatact ttgtattcgt tgtaattttt aacccttccg catcatcaat 3442681 gacctgaatc ggatttcccg cttcattata gccatactgt actttccggc catttggctg 3442741 tgtcatgaga agcgtctttt tatcagcatc atagctgtag acatatgttt cttttttagc 3442801 gttgatcgct ttttcgagac ggtgaccgct atactgatat tcggtaaaga caggctttgc 3442861 ttcggtactg ttagctgaat attgtttgac aaggcgccct tcactatcgt agtcatagct 3442921 tgtgacagtc ccgtctgtat ctgtaacctt cttcagcaaa tcattctcat atgagtaggt 3442981 gactttctta ttcttaggtc ctgtgatgga cgtcacatgg ccgttttcat cataggtaaa 3443041 tgtaagcttg cggcctgatg catctgtaat ggcggtcagt tgatttttgt cattgtaagt 3443101 atagacagtt gcattgttat ggccatccac taccttttgg agtttgccgc cttttttatt 3443161 gaaataagcg ttggtttgat cctttgtttt taatatgaac tgatcagctg tttctgttaa 3443221 ttcaagatat acaccggtcg gcggctgata cgtgccatcg gcttttttcg tgaatcgatg 3443281 tgtcgtagcg tcttcatcga tatacattgc cccgccatcc gttgagatga cagatgtttc 3443341 tgcatcagca taccagcctt gtccaaataa gtgatcagag ctgtcaagac tgttgtaggt 3443401 tctcgataag ccaagtcccg gaccgcgtcc atcaattgac aaatcttctt cattcacaat 3443461 gacattgcct gtcgcaccat ttaactggcc gcttgggata tcaatgatag accagtactc 3443521 ttctgtacct aggaattctg cgccttcatg gaacgttggg ttaaagggcg ccgttggaat 3443581 cgtttcacca ttcgcatcat aggcgacaag cgtgaaagaa taattcttct tccctttgta 3443641 attcccattt gcattgttat agacaggtga tggatcgagg gctaattccc cgccttttcc 3443701 atctgtatga agcttatagc ttccggcttt gatttcctca gaagtcggcc agatgttttt 3443761 attttgggtt gtccaatgat cagcatcacc aacatcaaag gactgatatt ctttaccgtt 3443821 gtaaatgtta actttatagc ccttcgcatt ttgaaccttt tcccatatca aattcacata 3443881 acccgtttga ctcgattttg tatttgtata caaatagcca gttacattct ttggcctagc 3443941 gatatcagga agtgccgggg tagcagccgg ggatgcaatg gcttcgccgt ctttgttgta 3444001 tgcgataatt ttaaacgagt aatttctttt ggctccatct cccccggcgt ttttataggt 3444061 tggtccggga ttgatcggca gctctgctcc gcttccgtcc tttaggtgaa gagcatattt 3444121 tcccgccttg atttctgcac ttgtcggcca gatctttttc ccttttgtgg tccaagacgt 3444181 ctgatttccg agatcaagtg tctcaaagcc tttcccattg aacacctgaa ccttatagcc 3444241 ggttgcaccg gatacagctt tccaagaaag gtcgaagtat cctgtggcat tcccattatt 3444301 gtagcccttt gctgacggtg cttgtgcttt tcctacatta gggataacgg gctttgccgg 3444361 tgcggacatc gctccttcac cttggtcaaa tatcgcactg acgccaatcc aatagttttt 3444421 gcttgtagca tagcttccgc cggaattctt atagaccggg gatggatcta atgccaattc 3444481 agctccatcc ttgccgtcca gatgcagttt atatctcttg gaggcaattt ctgcgctcgt 3444541 aggccagatt tttttacctt ttgtgctcca cgacgtgacg ttgcctgcag aaatcgcttg 3444601 atattcctta ccattgtaaa tccatacctt atatcctttt gcgccttcaa cctttttcca 3444661 gctgatatcg aaataaccag tggaatcgcc gttgtgatag gctttgattg taggtgtgtt 3444721 tccctttgga atggtatacg tcacttcaat atatggttta ttggcggagt tcgctgaaga 3444781 aattagtttt ttccaatatt ccttgccgtt tccgtttgta tgaagcttaa atccatagtt 3444841 ggccccgccg gagttccatg actttacagc agcggtcaca tcataactcg cccactgtcc 3444901 tttatggacg tcggcttttc cgatattttt agatgccggt ttggtgttcc atgtcacttt 3444961 tgcattatca taattgctgt tgaccgtatc cagccaaagg ccggttgcct ttgttccata 3445021 ataggaatgg gctacgtatg tttttaatgt agctttagtg acagtcatat tttgaattgg 3445081 ctttaggttg ttaaatttca tgaacgcata gtttgtgcct gttgttttgt cataatagcc 3445141 cgttttcagt acataggcct ttaaattagc atcccatttt tgtgaggagg ccgaatagtt 3445201 cgtcgtcggg taggcactca tgacaaacgt atccgatgaa acagataaag aagttgacgg 3445261 gtcgatagat actggatata cgcgttctgg gtctttcagc cagttctcgt ctgccgtaag 3445321 atgaagcaaa tacccttctt cattcttttc cagcttatag ctgactttgt ctgaccgttc 3445381 aacctcgccg gaaagctcat ctagttttga atccgtcata aaaggcttag gcacagaaaa 3445441 aacaactttt cctttttcat cagaaaaatc aatggatcca tcctcttgtt ctttagcctg 3445501 caaatcggtt tttaactgaa atgtaaatgt gttgtatcca ttatactgat gaaggactaa 3445561 atcttctttt atgttttcat tgaatgtgaa agtctgaaga tcaatattcg gaaacacatc 3445621 cggatacaca atctcattac tgtcagtctt ataatctgct gaggtatctt tcggagtaag 3445681 tgaagtttta ttcgggcctt tcgcttctgc tagtgaatat gtaaccttat ggtcattatg 3445741 ctcaaaagtc gcataaagcc cgttcttcat ttgcttttga aaatctgaat tcaaaatagc 3445801 gttctctgtc tcgacttgtt tgcttgtcga ctcttttaac tcaggagaaa tgtcttccca 3445861 gtcggcatcc ggtgtttcct ttgtatgaat aggatcaagg tatacttcct gtttatagac 3445921 accgtcacct tcataataga gttttgtatt ttctgttctt tcagaggtga tctcaccctc 3445981 tttgtttata tcttttggat caaaaggtac agcttcctca gtttgttctt tctgaagagt 3446041 ttcttctgga tcatcggcag caatacggtt tccattctct tcttctgtag attttgctag 3446101 tacatcggct ggcactaatg aaatcattaa agccaacact aaaaatgctg caatgaacct 3446161 tttaaagttt cgcctctttc tttttttcat ttcctctctc cttttgtaat aaaagtaata 3446221 tttactcaat aatcttaact agactgaaat atcattacaa tatttttcta gaaaatttat 3446281 cttattttaa ggattagcga gagtcaattg acctaaaaca aaaaaaggcc gcataggcct 3446341 ttttacattt tttattgtat ttgttcaata tccgtaccct cagctgtcac attcgccttc 3446401 ccctgcctcc tgacaagcgt caaggccatg cccgcaaaga tcattacgat gccaagcgtt 3446461 tgatagaggt cagggcggaa gcctgtgaag acggtatcga gcacgatcgc gacagcgggg 3446521 tcgagaaata caatgattga aataaatttc gttgataaaa atcgtaaact gtcaaaaaac 3446581 agcaaatata caatacccgt atggatgatg ccggtagata ccaccataat ccagtttccc 3446641 tgagataggt ccgcaaaagc gccaaagtga ataaacggaa tcaggatgat aacccctaaa 3446701 cctgtctgca agaaggtggt cgtgtaagga ctgagattgt gaatgccttt tcccaataaa 3446761 gtggtgaacg cataaaacag tgcggcgaga actgcccata tgatccctga tcccatcagc 3446821 tgtgtcaatg atgtgctgcc gttaatcccg gaaatcagcg cagtcccaag aaagcagatg 3446881 ataatggagc tgacggagat cacatttaat ttctctctgt agaagaagct ccccagaaga 3446941 agaacaagca ccggcgctag atgataaaca gagatggcaa ttgtaacgga cgtttcttca 3447001 aaagacttaa ataagaacac ccagttgaat acaagaaaga aaccgcacgc caatgtttgc 3447061 agcacgtctc tcttgctcca tttttcagtt ttatactggc cggacgccag ccagcaaaag 3447121 cctaaaaaca gcgtcgcgca aaggcagcgg acaaagacca attcaaatga cggcagattg 3447181 gtatgctctg agaaaaagcc gatggagccg aaaatcacca tagagatgac cattttgatt 3447241 acggctgttg atttttgttt tgacgatatg gaaggatcct gttgcatcaa acgtattcta 3447301 cctccaatac tgcatagcat aaactgtttt ttgtgaattc agaaatctac acatagaatt 3447361 cctctttttt acatgtagat attataacac ttctattcta aataaaaaaa agcgcccaag 3447421 ggcgcttttt ttacaaatct atcgaacaat caaaaccggg catgttgata attgagacac 3447481 tttatggctg acgcttccaa gcatcatttc tttcaggccg ctgatccccc ggctgccaac 3447541 tacaatcagg ctgacgcctt tctcttttgc gtgatttagt atctcatgcg ccggctcgcc 3447601 attcgcgtaa atggtttcag cttgaacgcc tttttcggct gctttttctt ttgcattctc 3447661 aaggattttc aggccctctt ttttaacctc gttcctgatt tcatcaataa agtgttcagg 3447721 cacatagaca attcccgtca gagaagaagt cgtgacgacg gcttctctcc ccacatgaag 3447781 aatgcttagt tccgcttgtt gctcttttgc caaatgcact gcggcatcaa gcgcttttgc 3447841 actcatgtct gatccgtcaa tcgctactaa cattttgtta aacatgctct tcccgccttt 3447901 cggactgtgg gtggttcatc tttctctttt attgtccgcc tgcatttcgt tattgtcaat 3447961 tgaagcgcat gagttttcaa aaaattgtca gagactctct ccgtttgtgg cgataacctg 3448021 ctgataccag ttgaagcttt ttttcttgat gcggttaaat gttccatttc cttcattgtc 3448081 ccggtctaca taaatgaagc cgtagcgctt tttcatttcc gcagtagatg cgctgacaag 3448141 gtcaattggc ccccatgatg tgtatccgat taattcaacg ccgtccgcaa tggcttcgcg 3448201 cgcttcaatt aaatgatcac gcagatagtt gattctgtaa tcgtcctgaa tcgtgccgtc 3448261 ctcttcaacc ttgtctacag cgccaaggcc gttttcaacg atgaacagcg gcttctggta 3448321 acggtcgtat aaggtgttga gcgtgatgcg caagcctttc ggatcaatct gccagcccca 3448381 ttctgatgat ttgaggtaag ggtttttgac tccgcccagc aggttgcccc ctgattttgc 3448441 aagctcttcc ggatctgtgc tcgccgccat cgacatgtag tagctaaatc caatataatc 3448501 caccgtatgt tctttcaaga gctcttcatc gccttcagcc atttcaattt caatattgtt 3448561 ttctgccaga tagcgtttca tatatcccgg gtatgcgcct cttgcctgaa catctgagaa 3448621 gaaaagtgtt ttgcgctcat tctccattgc cgcgaagaca tcctccggct tagaagtcat 3448681 cggataggtt gtcgttgccg ctatcataca gccgattttc gaatcaggaa tgatgtcgtg 3448741 acccgctttg acagcaagag cactggccac aaattggtgg tgtgccgcct ggtacatcgc 3448801 gtttaatttg ttttctcctt cttcaaaaac aagaccgcct ccggtaaatg gcgcatggag 3448861 cactacgtta atttcattaa acgtcatcca atacttcact ttgtgttgat agcgtttgaa 3448921 aaccgttttg gcatagcgtt cataaaactc tatgactttg cgattcttcc agccgccata 3448981 atttttcact aaaccgagcg gcatctcata atgagagatg gttacgacag gctcaatatg 3449041 atgctttaac agctcatcaa acagatcatc ataaaatctg aggccttctt cattgggctc 3449101 ctcttcatcg ccattcggaa aaattctcgt ccacgcaatc gatgtgcgga acgccttaaa 3449161 tcccatttct gcaaataagg cgatatcctc tttataacga tgataaaagt caatcccgtt 3449221 gtgatacaga ttcaaggaag tcattgattc atcaaatgga gacatgatcc cgttcggcga 3449281 tacgtcagct gtcgaaagcc ccttaccacc ctcgttataa gcaccctcca cttggttggc 3449341 agcaactgcg ccgccccata aaaatccttc tggaaatcgt ttttcatttg aactcatatt 3449401 gatcacccca ttagtttttt caagataaag caagcagcgc ttcttttggc tgcactttac 3449461 cgatctcttt caccggcgaa aacgaatatt ggtctgtgtt ggtcacaatc accggggtaa 3449521 tgacgtcata tcccgcggct ttgatttgct ccagatcaaa ggacacgagc ggatctcccg 3449581 gtgcgacctt gtcgccttct ttgatgtgag ccgtgaacca ttgtccctcc agctttaccg 3449641 tgtccaatcc aatgtgtatg agtatttcag ctccctgatc actcgtaatg ccaattgcgt 3449701 gttttgtttt aaaaatggtg gtaacgcttc cacgaacagg cgaaacaact tctccttctt 3449761 caggctcaat ggcaaatcct tttcccatga ccccagcaga aaacactccg tctttgactt 3449821 cacttaaggc tttcacttct cccttaatcg ggctgtgaat gatctctctg ctgccttcat 3449881 gcactgccgg ctgctggctg ccgtcagaag gcacatcctc gaatccaagc aaatacgcag 3449941 ctgctgttcc cgccgcaaac gcaatcacaa ggccgatcat cgcgtaaata aacgttgggc 3450001 cgataaagac agggatgctc ggcagacctg cattcccccc gacgatatag gaagcaacac 3450061 ccgtcatgcc gtaaaacgcg ccaccggctg caccgccaat caaagcggcc gcaaacggct 3450121 ttttcaatcg catattcacg ccgtacatcg caggttctgt gatccccatc agcgccgtga 3450181 tgcttgtggt aagcgcgagt gatttaaatt ttttgtttct agagcgaagg aagacggcaa 3450241 atgatgctcc cgcctgcccc atattcgcca aaaacatagc cggcagtaaa taatcgtggc 3450301 cgttttgagc gatgttgttg atcatgatcg gcacaaaggc atagtgcatg cccgtcataa 3450361 tgattaaaga gaatgtaccc gccagcaaaa tcattgccac aagccctgca tgatcaaaca 3450421 aataattgac cccagaagac aagtattctc ctaaaatagc gccaagcgga ccgactgtaa 3450481 tcaatgtcag cggcacgaca atcaatagcg tgaatgtcgg aaccacaatc aatttgagag 3450541 atgcgtgtgt aaaacggtca atccattttt ccacgtatga agcaatccaa atcgacagca 3450601 aaatcgggat gaccgttgac gaataagtgg cagcggttac aggaagcccg ataaaggaaa 3450661 tcggtttccc cgcaccgagc agggctgtca aatccggatg caggatcgcc gccgcaatgg 3450721 cagccgctac gtacggattg cttccgaatt ttctcgccgc actcatcgct agcaggagcg 3450781 gcaggaagta gaacgcaccg tcaccgacag ccgtcaaaat gacatgaacc tggctcttct 3450841 ccgccatcca gccaaacgtg actgccagcg ccacaagtcc tttgatcatc cccgctcccg 3450901 caatcgcagg cagaataggg gtaaacaccc cagaaatcac atcaaagacc gcactcagca 3450961 cattcttttt ctgagaggat gaaccagcgc tcttttcatc actgagattg ctgtgccgca 3451021 caatcgcctg atacaccttc ggcacatcgt ttccgataat gatttgaaac tgctcgccgc 3451081 tgatattggt gcccatcact ccaggcagct gctccagctg actgcgatcc gccttcgcgt 3451141 tgtcatgaag attaaaacgc agcctcgtca tgcagtggat cacgcgctga acgttttctt 3451201 caccgcctac gagttgtaat atgtccttcg ataatttatc ataatccatg tgtatacctc 3451261 ctttttatgg ggggactgct ggatgaaagg tggccgcctt tcaccagctt tttttgtatc 3451321 aaatgctgca tcacctccta aaagagaata aaaaaaccta aatgacacag attgcgagag 3451381 tctcctcctg cacctgcacc atttaggttt tgcctgcttt cgcagtaaca atcctgacgg 3451441 gtcgttttat ttgtttgtag gtatacttta gcactagatt cgtgagatgt caacgctttc 3451501 atttttggtg ttgactatcg tttctagaac aaaagtaatc ataaagattt gaacttagta 3451561 ttaacttcaa taaaaaatta ttgtaattaa aaaccttgaa aggcattttt tccaatcaag 3451621 gttatgaatc gttaccgttt aaattttttt aaagacttct ttatctgtac tattacattc 3451681 tttagccaat ctattggttc taaattaaac gcaggaagat acacgccatc tgcgcaagat 3451741 tgaatgtaat cgtttttctt attgtctgaa tgctcacttt caataaaatc cgttaaaaag 3451801 acaatagcat cctccaaata ttccttactt tcctctatta ataactcttg tatagcgtca 3451861 tcaggagttt caatatcttg atggaatgtt ccagctaaaa actgaaaaac agggtccttc 3451921 tgtttattga tcaataacat gtcatcttgc tcctttaagg gagaggtaac gggataatgt 3451981 taaaatcatt catcatctaa taaatcaaga taatactgat cattctcttc tatttttctt 3452041 aagaactcgg taagagaagt tgcaatttga atatcataat agtaaatcgg atttttatta 3452101 ttatcattta attcaattga cattaatgcc gattcactac cttcaaaaaa tattaattta 3452161 tcattctcaa actcatcata tatttctatg tcaggataaa attcaaagtc atttatcctc 3452221 aatcgaaagt ctcttacaga atatggatcc aaaatgcgat tagtattaaa ctctgatcct 3452281 ttaataaacc catagccaac ttctaaataa aaattcacta attcactagg taattttaag 3452341 tttaaatttt tttcaacctc ttcaatctca ctttgattca ctggataaaa atcattttct 3452401 ttgtttgatt ttataaaatt ataactcatt tttttttgcc tcctttaaat aattcatttg 3452461 ctggtgagcc tgtaccatga atcccagctt gatgctcgtt aggaaatttt gctggatgca 3452521 tattccacca ttcatgttct ccgccaaaag tattttcaat tatatggtga gcatcatact 3452581 tatccccttt ttttctaata attttacctg ttttttcaga tacaacattt tccttataaa 3452641 caggccattt ttgtccagtg ttttcttccc attcttttat aactttattt tttactttat 3452701 caaatttagt cctgtgtttt gcagtctcta ttggtgacat ttttttatat tctttatttc 3452761 ttaatgcttc ctttaattta tctatttgat ttttaggtaa ttctctacct gtgcgttgtt 3452821 ctatatctct agcatacttt tttattaaat cagaattaat tttattagca gatccactta 3452881 catcattcgc aattttccct ttatccttag caacgttttt aacttccgaa gccttcttag 3452941 cctttttccc attattaata agtttattaa tatctattaa cttttctaac ttagctattt 3453001 tggcaaatgg tactgagttt atggaggcaa caacacggtc tttccctgtg actttttcgc 3453061 ctgataccgg atctctgccc gtggctgctt taaatagatc atacacgccg gtaagttcta 3453121 cagccgtctc taaaattttc acatatccat tctcatccac tttaatgtcc gaaagcgaga 3453181 cgacaggttc aagcttcatg tcattaccag atatgtatac attgtaaagt gtatcattat 3453241 aaacgacttg cttaacctct gcatttgaga aatcagtttt tatatgttct ctatgttcac 3453301 tcgtattata cactttacca ttgataacga tgatattttt acttaccttt ttagaatcac 3453361 ccgttttgac aactgaatcc actttagact tttcattctc ggctaatttc ttcagcatca 3453421 tctccatcgg tgaatcatcc gcctgcttca tttgcgggtt aatcgcgccg aagatttggt 3453481 tgatgttttc ttcttcctgt gatttcagga tggagccgct tttgtagcct gtgatttcaa 3453541 ttttcgggcc ggtgtacatg gtttcgagct gatcaatgta ttttttcatc gtttgaaaat 3453601 ctgattttgc ggcttctagt gcttgggttt gctggccgtc aaattgaaag agcttattca 3453661 gggtgtctga aatcagccgc tcagcctgtt ctgtttccat ccgaaaaaag gaatcattga 3453721 ctgtcggcag gctgacgatg tgatctatgg ctgatgtctg gcgattgact gcgtcagtga 3453781 gctgctctgt cacttctcgt gcatgcttga ccccatgtct cgcatcgtgt gagagaaaag 3453841 cctctgcgat catgccgtgg gagttagatt ctacagagga aatcgcatgc tgtgtttgtt 3453901 tcagcacttt tttgtattcg tcgataaata tgccaaagaa aaggagaaaa ggcttgtggc 3453961 actcctcgta aaaggtccgg atggcatctc cgccttttcc tttcagcgca tccttcatgc 3454021 ctgccagatg ctcaacgctt ttttccagct tctccagctg ttgtttttgc ttgtccagtt 3454081 tctcaatcgt atgctgaatg ccctcgtgaa gagcgtggac atctaatgtt ttcaatccct 3454141 tgtcctcccg cgctttattt catggaagat gatatgtttt cgtccgtttc cttcatggcg 3454201 tttaccgcgc tttccgtttg tgcgatatgc ttggccagaa cagacgcata tgcttcagtg 3454261 agctctttga tgtccttatt taattgctcg atggacttca caacattcaa atggtttctg 3454321 cctgagagat gaccgggcaa tgaggacttg agttcagctg aattcttgag ctgagaaagc 3454381 ccttgcttca ctgtgtcata caccatttta atttcctgtg ccatttgtgc tcacctcact 3454441 ttttatgttt ttccttctct atttcatgct ctatcctcgt gatttggcgt cttatagaat 3454501 acacatcgcc ctctaatgag tggatttttc cttctatgct ttcgatgatt ccgctgactt 3454561 gatcgctttt gatttgctga tatgctttgt tcattccttc acgaatatct tcaaaccgct 3454621 cagcatgtgt tcctctccat gcctcccggt taagatgagg ccggtgaatg agatgctggg 3454681 cctcagagaa atcgtgtttg atttgcctaa tttcgtgcag cactcgtttt aattgatgga 3454741 tctgttcctg cttttcatgt aagtcggctt ttaccgaatg taacaacatt tcactatgca 3454801 tgccgcaaca cctcgtgttt ctatcaaact gtgtaaattc tttacaatac agactatttt 3454861 catattacat gatgggtcat attggataaa taggtaaaaa ggattgtctt gagaggtata 3454921 gaactggttc taaattgcta aaaatacgat ctcatcaccc tatgaaagga gaaaacaatc 3454981 atagtaggga ctttttattt aagcctttaa tctctcctcc agttctaatt tttcctccca 3455041 cttaactgtt tcttatagtc aataaagctc ataaaaaaac accttccctc gaaggcgctt 3455101 ctccatctta tttagatccc catacagcct caccgctggt attcagcaca ctaaacgtca 3455161 tgacgttctt ctctctcacc gaatcccact ggcgtaaaaa taccccgtta tacttcttgc 3455221 ctgctaacgt gatgtcggcg gtgttttttc cggttttcct ccatgttccg gtcatttccc 3455281 cggaaatggt gtggtttttg ttgagctgga tgttgatggt ttgtttgatg tcggctgaga 3455341 tgtcttttcc gtgctggata agtttgtatg ttcctgtgat gtctttttgt tttacttctt 3455401 tcaatgtttc gcccgcataa cgatatggtg ctgctaccgg ccagccgtct ttgttcatga 3455461 acaattggtg gactctgact tcgtgttctt cacccctgcc cgggaagcgg gtgtggaaga 3455521 ttaaatagga acgcccggtt ttttcatcat agtatgcgga gttgtggcct ggtgagacgt 3455581 acccggtgcc tttttcattt tctgtttcaa aagtgtagct gcccatgagt ttgacgccgt 3455641 atggttcgat ggaacggtcg tcgaagaatg tgcctccctt gccgcggacg tcgagcattg 3455701 gattgccttc tgcatcatag taagggccgt ccggtttctt ggagcgggcc acacggatgt 3455761 tgtagccgcc tgttgcatcg agaccgccat atgataggta taagtagtag tattgggtgt 3455821 ctggattgta gagaacatac gggccttcga ttctgctgtg gttgccgccg agcagttttt 3455881 tcccatatcc ctgtccagga agcgggaagc ccgttttcgg attcatttca agtatgaaaa 3455941 tgccgcctga gtatgatccg tacaccatcc acagcttgcc gtctttatca aagaaggtat 3456001 gcgggtcgac gacattcgga tgtttggttg catcatacgg tgttccatcg ctgcttgtgc 3456061 cttccattcc tgatttcaaa aagatgcctt tgtttttgta tgggccttcg atgttgtcag 3456121 caacggcaac acccatggcg gatcttggcg aatcgccgcg gcaggcgttg tagtacatgt 3456181 agtatttgcc gtccgccagc tgcgtgacgt cagccgccca aagagtatcg gattgcgccc 3456241 attcgaaggt ttcttttaat tcttcataga cattcgggat aagtgggttg tcattgctta 3456301 cgctggtggt cagctgctgc cattgcatga ggtcattcga tttagctgaa gcgagatgag 3456361 atccaaaaac ataaaaagtg ccgtttgttt caatgatgga agggtcatgg acgctgactt 3456421 ctttaaatat aggtttttgt gcatagacgg agtttgggag ggtgaaggcc atgataagag 3456481 ctgcaagaaa acatacacgg aacaatcggt tgaacatcta aacaattcgc ctctcttttt 3456541 tattaaattt taaacgctta catttctcta tgaagatacc ccggcctatt aaaacagccg 3456601 aatgttttca tattcatcca gataggtgat ttctcacttc acttacatag tcagactgat 3456661 gtctgtctgt tttgcgcaga acttgttgct tgcatatcct ctccttcata gttcaactct 3456721 tttgctgttt ctccttcttg catcacgtct gtttttcttt cgcgtacatg taataactgc 3456781 tttgtcaggt tttgcatcaa ctgtgataca gccatttcgt tgtcggcgtt ttttaagatg 3456841 atgcctgatt gcccgtcaac accagagtca ttcggctggc tctttataaa acgccttgcg 3456901 aaaaatacga cttagtaaac gcatattgag agttagacag cggcgcttgc ctccttgtct 3456961 ggatatcgtg tgcaatcgct gaaaaaacct gttctgcttt ctgcgtcacg ctattacaat 3457021 agcaatctaa cttgttaaag actataaaaa aaccttttga cttctgctgc tgaaccaatt 3457081 aatataatac tcagttaata gttatcagaa tttttaggaa ttgagtgatt catatgacac 3457141 tgcataaaga gcgtcggatc ggccggctgt ctgttctcct gctgctgaat gaggcggaag 3457201 aaagtacgca ggttgaggag ctggagcgag acggatggaa ggtctgtctt ggcaaggtag 3457261 gatcaatgga cgcacataaa gtagtagccg caattgaaac cgcttccaaa aagagcggtg 3457321 tcattcaatc tgagggttat cgggagtcac atgcgcttta tcatgcgacg atggaggctt 3457381 tgcatggcgt gaccagaggt gaaatgctgc tgggatcgct gcttcggacg gtgggattga 3457441 ggtttgccgt tttgagggga aatccttatg aaagtgaagc ggaaggcgat tggatcgctg 3457501 tctcgcttta cggaacaatc ggggcgccga ttaaaggtct tgagcatgaa acattcggcg 3457561 ttggaattaa tcacatatga aacagcccat agatcttaga cgataggggg ctatgcgtga 3457621 aaacagaagt tcacagcata gctccttttt gtatgggcgc tttaccaaag taaagaaaaa 3457681 ggagttgggc ttatggtgac tttagacggt tcttcattga caacagccga cgtcgctcgt 3457741 gtgctgtttg attttgagga ggcagcggct tctgaggaaa gtatggagcg cgtgaaaaaa 3457801 agcagagcag cagtggaacg gattgtacgc gacgaaaaga caatctacgg catcaacacc 3457861 ggatttggca aattcagcga tgtcctgatt cagaaagaag actcggcggc gctgcagctg 3457921 aatttaatcc tttctcatgc ctgcggagtc ggcgaccctt ttcctgagtg tgtttccagg 3457981 gcaatgctgc ttttgcgcgc caatgcgctg ttaaaaggct tttccggtgt acgcgctgag 3458041 ctgatcgagc agttgcttgc ttttttaaat aaacgcgtcc atcctgtcat ccctcagcaa 3458101 ggatcacttg gcgcaagcgg agatctggcg ccgctttccc acttggcgct tgcgctgatc 3458161 ggacaaggag aagtcttttt tgagggggaa agaatgccgg caatgacagg cttgaaaaaa 3458221 gcaggtattc aaccggtaac gctgacatcc aaggaagggc ttgccttgat taacgggact 3458281 caggccatga ctgcaatggg ggtggtcgcc tacatcgaag ctgagaaact agcctatcaa 3458341 acagaacgaa ttgccagctt aacgattgag gggttgcagg gaattatcga tgcatttgac 3458401 gaggatattc acttagcccg cggctatcag gagcagatcg atgtcgcaga acgaattcgc 3458461 ttttatctat ctgacagcgg cctgacaacc tcccagggag aactgcgggt acaggatgcc 3458521 tattcattgc gctgtattcc gcaagtacac ggtgcgactt ggcagacact aggatatgtc 3458581 aaagaaaaat tagagattga aatgaacgca gctacagaca atccactcat tttcaatgac 3458641 ggtgacaaag tgatttccgg cggaaacttt cacggacagc caatcgcctt tgccatggat 3458701 tttctgaaaa tcgcaatatc agagcttgcg aatatcgcag agcgtaggat cgaacgactt 3458761 gtgaatccgc agctgaatga cctgccgccg ttcctgagcc ctcatcccgg tctgcaatcc 3458821 ggtgcaatga tcatgcagta cgccgcggcc tcactcgttt ctgaaaataa aacactggcc 3458881 catcctgcaa gtgtggattc cattccgtca tccgccaacc aagaggacca tgtcagcatg 3458941 ggaaccatcg ccgctcggca tgcttatcag gtgatcgcaa atacaaggag agtcattgcg 3459001 atcgaagcca tttgcgcatt gcaggctgtt gaatacagag gcatagaaca tgcagcgtcc 3459061 tatacgaaac agctttttca agaaatgaga aaagtcgtgc cgtccattca gcaggaccgt 3459121 gttttttcct atgacattga acgcttgact gactggctga agaaagaatc tttaatacct 3459181 gatcatcaga ataaagaact aagggggatg aacatatgac tgatgtaaaa aaatcaatcc 3459241 gtgccaacag aggaacagag cttgaatgct taggatggga gcaagaggca gtgcttcgga 3459301 tgcttcgaaa caaccttgat ccagaagtcg ccgagaagcc ggaggacctc atcgtatatg 3459361 gcgggattgg caaagccgca cgggattggg acgcttttca cgccattgag cattccttga 3459421 aaacattaaa aaatgatgaa acattgctcg tgcaatccgg aaagcccgtt ggcatgttcc 3459481 gtacacaccc gcaggcccct cgcgtgctcc tagcaaattc tgttcttgtt ccgaagtggg 3459541 cagactggga gcatttccac gaacttgaga aaaaagggtt aatgatgtac ggacagatga 3459601 cggctggcag ctggatttac attggctcac aaggcatatt gcaaggaacc tatgaaacct 3459661 tcgctgagct ggcgcgacag cacttcgggg gcagcttaaa aggaacgttg acgctgacag 3459721 cgggtctcgg cggaatggga ggcgcccagc cgctgtcagt cacgatgaat gaaggcgtcg 3459781 tgattgccgt cgaggttgac gagaaacgca tcgacaagcg gatcgaaaca aaatactgcg 3459841 atcgaaaaac agcatcgatt gaggaagcct tagcttgggc tgaagaggca aagctggcag 3459901 gaaaaccttt gtccattgca cttctcggaa acgcagctga ggtgcatcac acacttttga 3459961 accgaggcgt caaaattgat attgtgacag atcagacatc tgcccatgac cctttaatcg 3460021 gttatgttcc cgagggctat tcccttgatg aagctgaccg tttgcgtcaa gacactccag 3460081 agctttacgt gcgccttgcg aagcaaagca tgaaaaaaca tgtcgaagcc atgctggcct 3460141 ttcagcaaaa gggctctatt gtatttgact acggcaacaa tatccggcaa gtcgcaaagg 3460201 atgaagggct ggagaatgcc ttcgattttc cggggtttgt ccctgcctac atccgcccct 3460261 tattctgtga aggaaaaggg ccgttccgct gggcggcgct ttccggagat ccggcagata 3460321 tttaccgtac ggatgcgtta ttaaaagagc tgttcccgac aaataaagcc cttcaccgct 3460381 ggattgatat ggcacaggaa aaagtcacct tccaaggctt gccgtcccgt atctgctggc 3460441 ttggatatgg agaacgaaaa aagatgggcc tcgccattaa cgagctggtt agaaccgggg 3460501 agctaaaagc gcctgtcgtt attgggagag atcatttgga ctgcgggtct gtcgcctctc 3460561 caaaccggga aacagaagcg atgaaggatg gaagtgacgc tgtcggtgat tgggctgtgc 3460621 taaatgcgct tgtcaacacg gcggcgggtg caagctgggt ttccttccac catggcggcg 3460681 gcgtcggaat gggctattcc cttcatgccg gcatggttgc agtggccgat ggaagtgagc 3460741 tggctgacga gcggctcgcg cgggtcttaa cgagcgaccc aggaatgggc attatccgtc 3460801 atgcggatgc gggttatgaa cgtgccgttg aagtagcgaa ggaacaggac attatcgtgc 3460861 cgatgcaaaa ataaaggagt gatgacatgc caaagcaaat tgatacgatt ctcatcaaca 3460921 tcggtcagct tttgacgatg gaaagcagcg gtccgcgggc aggcaaaagc atgcaggatc 3460981 ttcatgtgat cgaagacgct gttgtcggca tccatgaaca gaaaattgtg ttcgccggac 3461041 aaaaaggggc tgaagccggt tacgaggcag acgaaatcat tgactgttcg ggacgccttg 3461101 taacgcctgg cctcgttgat ccgcacaccc atcttgtatt tggcggatct cgtgaaaagg 3461161 agatgaacct taagcttcag ggcatttcat atttggatat tctggcgcag ggcggcggga 3461221 ttctgtctac agtcaaggat accagggcgg cttcagaaga agagctgctg caaaaagccc 3461281 attttcatct gcaaagaatg ctgtcctacg gcacaaccac agcagaagtg aaaagcggct 3461341 acggcttgga aaaagagaca gagctcaaac agttgcgtgt cgcaaagaaa ctgcatgaaa 3461401 gccagcctgt tgaccttgtt tccacattta tgggagccca tgcgattcct cccgaatatc 3461461 aaaacgatcc agatgatttt ctggatcaaa tgctttccct tttgccggaa atcaaagagc 3461521 aggagctcgc cagctttgct gatattttta cagaaacagg cgtttttaca gtcagccaat 3461581 cccgccgtta tttacaaaaa gcagctgagg caggcttcgg attaaaaata cacgcagatg 3461641 aaatcgatcc gcttggaggt gctgaattag caggtaagct aaaggccgtc tcagccgacc 3461701 atttggtagg tacatcggac gaaggcataa agaaattggc tgaggcagga acgatcgccg 3461761 tcctcttgcc gggcacgaca ttttatcttg gcaaaagcac atacgccagg gcaagagcta 3461821 tgattgatga aggtgtatgt gtcagcttgg caacggattt taatcctggc agctcgccga 3461881 ctgaaaatat ccagctgatt atgtccattg ccgcgcttca tctgaaaatg actgcagaag 3461941 aaatatggca cgcggtcaca gtcaatgccg catatgccat aggaaaagga gaagaagccg 3462001 gtcagctcaa agctggccgc tcagctgatc ttgtcatttg gcaagccccg aactatatgt 3462061 atattccgta tcactacggg gtcaatcatg tacatcaagt catgaaaaat ggaacaattg 3462121 ttgtcaacag ggagggagcc attcttggat aagtaccctt ttctcagaga ggccggatct 3462181 tcgtttaaag accgggatgt cacaaaaatg agcgacctga tcgcaacatg ggacggccag 3462241 gacattaagg gaccggcgtt gataggtgtc cccctatcaa aatcctccat cagtcattca 3462301 ggcgcttcct ttgcacccgg aacaatacgc caggctctga aacattcatc agcctattct 3462361 gctgagcttg gagagcacgt cgtatcagag cttctatatg acctggggga tatcgatatt 3462421 catgtcactg atatcgtaaa gtcacatcat cacattttcc aaaccatgca cgctctgctt 3462481 tcggatcatc cggattgggt gccgctcata cttgggggag ataactctat cagctactcc 3462541 acaataaaag cgatagcaca aacaaaagga acgacagcgg tgattcaatt tgatgcccat 3462601 cacgatgttc gcaatacgga ggacgggggg ccgacaaacg gcaccccctt ccgccgcctt 3462661 ttggatgaag agatcattga aggtcaacat ttgatccagc tgggtatcag agaattcagc 3462721 aacagccagg cctatgaagc atatgcaaaa aaacataacg tgaacattca cacgatggac 3462781 atgatccggg aaaaaggact aatcccaacg ataaaagaga ttttgcctgt tgttcaagat 3462841 aaaacagatt tcatttttat atctgttgac atggatgtct tagaccagtc ccatgcaccc 3462901 ggctgtccag cgattggccc gggcggcctc tatacagacg aattgcttga agcagtcaag 3462961 tacatcgcac aacagcccaa tgttgccggg attgaaattg ttgaagtcga ccctaccctc 3463021 gattttcgag atatgacaag cagagctgca gctcatgttc tgttacacgc attaaaagga 3463081 atgaaactct ccccattcaa gtgatcttct ggcaggttgt attttgggta taagaaactc 3463141 atctgcctaa ggaatggcag ctaaaaggag ggcgagacag tgaatcttca ggagaacagc 3463201 agccaacagc taaaacgcac aatgaaaagc aggcacctat ttatgatctc attgggaggc 3463261 gtcataggca caggactttt cctcagtacg ggctatacgc tacatcaagc cggacccggc 3463321 ggtacgatac tcgcttatgt aatcggcggg ttgatgatgt acctcgtcat gcaatgtctc 3463381 ggcgaattgt cggttgccat gccggtgacc ggctcttttc aaaaatatgc tacaacattt 3463441 atcggtccat ctaccggttt tatggtcggc atcatgtact ggatcaattg ggtggtgacg 3463501 gtaggctctg agtttaccgc atccggtatt ctcatgcagc gctggttccc tgacagcagt 3463561 gtatggatgt ggagtgcgat ttttgcagcc cttcttttta tatgcaacgc attttcagtt 3463621 aagttatttg cggaaactga attttggttt tccagcgtaa agattgtcac cattatttta 3463681 tttatcattt taggaggagc cgccatgttt ggcctgatct ctttaaacgg aacggcggat 3463741 gctcctatgt tgtcaaactt cacagatcat ggcgggttgt ttccaaatgg ctttctcgcc 3463801 gtttttatcg cgatgatatc tgtgagcttc gccttttccg gtacagagtt aatcggcgtt 3463861 acagcaggag aatcagcaaa tcctcaaaag gatataccgc gatccatccg taatgtcgca 3463921 tggagaaccg tgattttttt cattggcgct gtcttcatat tatccgggtt gatttcatgg 3463981 aaggacgcag gcgtgattga aagcccgttt gtcgccgtat ttgcggagat cggaattcct 3464041 tacgctgctg atattatgaa tttcgtaata ttaacagcct tgctgtctgt cgccaactca 3464101 ggcttatatg cttcgacccg tatgatgtgg tctttagcaa atgaaaacat gatcagctcc 3464161 cgttttaaga aagtgacatc taaaggcatt cctttaaatg ccttaatgat cagtatggct 3464221 gtatcttgtt tatctctcgt ttccagtatc gtggcccctg gaactgtcta tgtggtgatg 3464281 gtcgcaattg ctggatttgc aggagtcgtg gtctggatga gcattgcctt gtcccaactc 3464341 ttgtttcgaa agagattttt gaaaaaaggg ggggatgtaa aagatctgac atttcgcacg 3464401 ccgctttatc ctcttatgcc tatagccgct ctcttattat gttctgcttc ttgtatcggt 3464461 cttgcttttg atcccaatca aagaatcgca cttttctgcg gagttccttg tatcatcctt 3464521 tgctatctca tctaccattt caaaagaaat gttacaaaag cgaaaaaaat cagccaagag 3464581 gaatatccag ccgatcacat cctataatta aaaaagcaca ccccgctcag catgggatgt 3464641 gctttatttt ttattctgta attaacgtat gaatcagctt cggcgccttc gcttccgcgg 3464701 cgatgcggat gttgtcatag acttttgcga tgacttcatc gacgttttct cggttagcgt 3464761 aaagcgttac gagcggttcc cctttttcta ctttgtcgcc gacctttttg cggagcatga 3464821 tgccgacggc taaatcgatt tcgtcttctt ttgtggcgcg gccggcacct aacagcatcg 3464881 ccgcgacgcc gatttcgtcc gcgacgattt cagagacgac acccgcttct ttggcaggca 3464941 catcaatttg atatgcggct tgcggaagct tagacggatc gtcaacaatt gagctgtcgc 3465001 cgccttggtt tttcaggaaa tccttgaatt tctcaagtgc tttgccgttt ttcatgactt 3465061 cttccagctt cgctctcgct tcgtccaatg tatcggcttt tttcgcaagc acaaccatct 3465121 ggctgccgag cgttaagaca agctcatgaa gatcctcagg cccctcgcct ttgagcgtgt 3465181 cgatcgcttc tttgacttca agcgcatttc cgatcgcaaa gccgagtggc tgggacatgt 3465241 ctgaaatgac agccattgtt tgacggccga cgttatttcc gatgcgtacc atcgctttgg 3465301 caagttcagc tgcgtcttct tctgttttca tgaaggcgcc cgctcccgtt tttacgtcaa 3465361 gcacgatggc gtccgccccg gcagcgattt ttttgctcat aatcgagctt gcaatgagcg 3465421 gaatggaatt gaccgttccc gttacatcac gaagcgcgta cagtttttta tcagccggcg 3465481 ttaaattgcc gctttggccg atgaccgcaa ccttgtcgcg gttcacaagt ttaataaatt 3465541 catccttcgt cagttccacg tggaagccca tgattgcctc taacttatca atcgtgccgc 3465601 ccgtatggcc gaggccgcgg ccggacatct tagcaaccgg cacatcaaga gccgcaacaa 3465661 gcggagcgag aacgagcgtt gtcgtgtcgc cgacgccgcc ggtagagtgt ttatccactt 3465721 taattccttc aatggcagaa agatcaatcg tttcaccgga gttcaccata gccatcgtca 3465781 agtccgcgcg ttcacggtca ctcatatcct ggaagaaaat cgccatagca agcgcgcttg 3465841 cctgataatc aggaatgctt ccatctgtat agccgttcac aaaaaattga atttcttcag 3465901 tggtgagttc ttttccgttt tgttttttga tgatgatatc taccattctc atgtttggtc 3465961 accgatcctt ttcgattaag ttcagtaaat caagcccaca attgctgctg ataaaaagct 3466021 gacaagcgta gcaccgtata ataatttcaa gccgaaacga gcgacgacat ttccttgctt 3466081 ttcattcagt ccttttacgg caccggcaat gattccgatt gaggagaagt tcgcaaatga 3466141 cacaaggaat accgatacga tcgctgttgt acggccgctg aaatggaaac cgttttgcgt 3466201 aagcgacgtc atggcgacaa attcattcga taccattttt gttgccataa tgcttcccgc 3466261 attaacagct tcattccatg ggataccgac aagaaaagcg aatggagcaa acacatatcc 3466321 aagaatgcct tggaacgaaa taccgaatac tgcattaaaa atgccattga tcaatgcaat 3466381 aatcgcgaca aatccaatca gcatcgcagc gacgacaacc gctactttga aaccgtcaag 3466441 aatgtattct ccgagcactt cgaagaagga ttgtttttct tcttcctcaa cacgaagcat 3466501 atcctcttct tttgcaacct cgtacggatt gataatagaa gcgataatga aaccgccaaa 3466561 taagttcaaa acaagcgctg ttacaacata ttccggtttc agcattgtca tatacgcacc 3466621 gacaatcgac attgatacag ttgacatcgc agatgcgcaa agcgtgtaca agcgctgctg 3466681 atttaaaaga ccgagttctt tcttcaagga gataaatact tctgactgcc ctaaaatcgc 3466741 agaagccact gcgttatacg attccaatct tcccataccg tttaccttgc tgagggcaag 3466801 gccgatatat ctaatgataa acgggaggac tttccacttt tgcagaatcc cgatcagagc 3466861 ggaaataaac acgattggca agagaacatt cataaagaat gtcgtttggt ccgcattcac 3466921 caagccgcca aacacaaagt taattccctc tgccgcgtat tcaagcaggt aaccgaatcc 3466981 ttttgcaaat cctcccacga ggaaattccc tattccggta ttgaggagaa tgtagccaag 3467041 aataaattgc aaaatgagca taacaacaat tgggcggatc ttaattcttt ttttgccgct 3467101 gctcgcgatc cacgcgaggc ctaaaaacac gattaaaccg ataatcccaa tcaaatactt 3467161 catatgtgtt tctcctttat ttgtattcgc ttacaattac tgtttcctca gaaaacggaa 3467221 agcagtctgc cttccgtcag ctcttaatag ttgtctccgc ctgatgcatt ttctcctttt 3467281 acgatagaaa cgcctgcgct ggcgccaatt cggcttgctc cggcctctac cattgtgtct 3467341 acatcttctt tcgttctgac gccgccagat gctttcacgc cgatatcagg ccctactgtt 3467401 ttgcgcatta aggcgatatc ttccttcgtt gcgccgcctg tagaaaagcc tgttgatgtt 3467461 tttacgaaat ccgctcccgc agacaccgct aaacggcatg cacgttcttt ttcttcatca 3467521 gtcagaaggc acgtttcgat aatgactttg acaagcgctt ttccggctac agcttccact 3467581 acaccgcgga tatcagcttc caccacatcg tcttccttgt cttttaaagc ggcaatatta 3467641 atgaccatat ccacttcagt ggcgcctttt gaaatggcgt cttttgtttc gaacgctttt 3467701 gtttcagttg tattggcacc gagcgggaag ccgatgaccg tacaaacgtc gactccagtt 3467761 cccttaagct cttttgcagc aagctccacc catgtcggat tgacacatac tgaagcaaat 3467821 ttgtatgttt tcgcttcttc aattagtttt agaatgtccg ctttttgtgt atgcggtttc 3467881 aaagctgtat gatcaattat gttggctaat gacatccttc gcacacttcc ttttttgtta 3467941 agatattttt tagcataacc gacttttgaa catatgtaaa ttggtaattg aaattttgtt 3468001 caatgaaagg tttgaacgtg tcacaaatca ttaacaagcg ccctcgcggt atgctggtca 3468061 atgattaaaa cgttggcata ttttccggtt aatgctccgt gaatggaaga tacttttctg 3468121 cttccgccgg caactaaaat ggagcgttcc ttcagtctaa ggtcttgaag ctcaacaccg 3468181 atggtccggt cattgatggc gctgctgcaa atattccctt tcgcatcaaa aaagcgtgaa 3468241 caaatatccc cgacggcctg ttttttcagc agggctttct cttcttcgtt aaaatatccg 3468301 agccgaaaca acagcgcttc atcacggaca gtcccgaccg taaagagagc gatattcgcc 3468361 tgcttgccca tctcaatgat ccgttcaata tgacggtctt tctccaccat tcgcttcaca 3468421 tccgcattat caaacacgac gggaagcggg agatagcgcg gcatcgtttg aaaagcctct 3468481 gcaaacagct gaatcgtttc agccgaatac gtgtttaccc gggaatggct gatgccgcct 3468541 ttcagctgga cgacctcgac gccttttacc tgcttcggct gcatgttttg cgcgatttga 3468601 tacatggtgg ttccccagct gacgccgaca atgtcgccgt cttttaccgt ttcatgcata 3468661 tattctgcac catagcggct taggtcatgt gtaattcctg cataatcggg tgtcggggaa 3468721 aacacaacat gcgcctcaag gagcccgtat ttctcttcaa gtatggaacc gagcgcatcc 3468781 aaatcctcaa aagggtccat gacgcgaatc tggacatacc ctttttcctt tgcatattgc 3468841 agcagccggg aaacggttgg ccttgaaatg ttgagctgct cagcaatttg ctgctgactg 3468901 tagtcagact gatagtaaag ccttgccgct tctatgctta attgctgttt ttcccgatcc 3468961 attctgcacc tccctgtgga tcagtcctga taaaactgct tttgatttgc ttttattata 3469021 caggctggcg ccggctttca tccacctgat ttctaagaaa ctgaaaaacg ctctgggcgc 3469081 ggacctgccc agagcttact tctcccaagt catatgctga taaatgcctt tcataatggc 3469141 gtacattcca tataggatca ggcctaatgc caatatagac agaatcaatt tgccatgcgg 3469201 ctgctgcgcg agttctgcga gcgcgccgtc aaagcctctt gtgtcgtcgg gatcagcggt 3469261 catggctgtc ttgatgagaa aatagccgat agccgagaaa ataatggccc gggcgatatt 3469321 gcctgcgcgt cctgtgtttt tcgtgatgca tatcatctgt ttgttcattt ttgatgtatc 3469381 gaattctttc ataaaagcag cccgaacgcc tttcataaat tgaacaatcg caaatacgat 3469441 aaaacccgca cccgtaagcc ctgtgagcca ttggccgaac ggctgcgcca atacataagc 3469501 ggaccacgtc tgttctgaag tgccgccgtc cccttggcca aacacaaatc gcaaggcatt 3469561 ccaagcgatg gatgtgtaaa cagcggcact gaaaaagttt cctattctcc gcgacaggcc 3469621 tcgcctgctg tttccgtgcc cctccgtgtc cttgatcgcg cttaacacca tccagatcac 3469681 atagccgata aggccgatgc ctataaaaaa aagcaatagt gacccatacg gcatgcgtga 3469741 tagcgtttgg agagctccgc tcgaatcttt ggcgcggcct gccccggcag ccgtcataaa 3469801 agccaaaacc ccaagcagaa taaaaacgcc gccgaatgca aaataaccaa gcctcccgaa 3469861 tcgtttgatc caaggcttgg tttcctgttt tatttttgac atgtaccggt ctttcaccgc 3469921 catgtgtcca accctctttc acagaaatct ttactgtaac attcccgatt gaacaaagtt 3469981 gaaacagctc ctgcctcagc tatggctggc tgagatacgt ttttgctgtt tagctgattg 3470041 tgcaggtgtc atccaagcag ccgctgcggc agctgtgact ccgcctgcta atttcccaat 3470101 gatcatggcc gccgccattt cttttttcat tccagctaca aaaccgagat ggctgccgag 3470161 tacaaaggcg ccgctgaccg caaacgcgac attgatgacc tttcctctcg gcgtcatatc 3470221 ctttaatgaa gccagcattg ggatatgatg cgccaaagag gtcactaagc ctgctgttgc 3470281 tgtctcatct aaatgaaggc atttccccag agcctgaagc ggttttttaa aggtttttgt 3470341 aataaatgcc gtcatcggga acgcccctgc cagagcaatg gcgatggtcc ctgtcgtttg 3470401 tatccctgtc tcgacattct ccattcccgg aatcagcaca atgccggtca tcgtttcaac 3470461 agaaacagct gcaagcccga taatcgcaac catactgacc gctttcccga agagatgaaa 3470521 caactgaatc attctgtcgg tgtatcgcca taacccaaaa gcgatgacag cagataacag 3470581 actcgggatc agaagatttt tacctatcat gccgatgtca aagcctgcgc ataatccgcc 3470641 gattaagcaa ccgatcggca ctgtgcacag cccgattaat atgcctttcg caaaatacgg 3470701 atgatcctct ttttcgatga tgccaagagc gacgggaatc gtgaagacga ttgccggccc 3470761 catcattgtt cctaaaaaca cccatgaaaa cagcccggcc tgcggatctt tcgccatttc 3470821 tccagccagc gcatatcctc ccatatcaat cgccaaaatg gtgttcgcaa aggaagaagg 3470881 atccgcgcca atcgctgtgt aaaacggagc aacaatggga atcaagattg ctgccagcac 3470941 gggcgccagc gatacaattc cgatcatgga cagcgccagc ggccccatag ccttaaagcc 3471001 gtccgcaaac cgctcgccta gcccccatct gtttcccaaa caataatccg ctgctcccca 3471061 tagtaaaaag gcagccaaaa tgaatacaac cgcgtcattc accgtcatgg ttttctcctt 3471121 tttcaaacgt atgattggtt ttatcatatc atctgaaatc accgaataga gttgatctta 3471181 ttcaatatga gctaaaaatt cttttatatc ggctttttca acggctgtta taatgcgtcg 3471241 cgctttttct tgcgggaccg ttaatgtcaa tttttctatt atgtcttctt cagacagctc 3471301 atttcctggt gccccttttg ggcagtccac acgcgcttcg caaatccggc cgtctgataa 3471361 ataggcccgg acaatcgtga aacggccttt tggaacggca tgaggagccg gctgaatagc 3471421 attgtcatat acgcgctgaa ttcgccccat tgtcgtttga accccgtttg ggatcggctg 3471481 gctgctgaaa tgttcaacgg tcaggccgtg tccatgcaaa gcaagagcaa tcacatattc 3471541 aacgctgaaa cggccttcct ctccagcttt tggagatctt tccgtcaatg cagcatctcc 3471601 gcctggcgga aatatcactt caatacgttc ggtattggca gcagaaatgg tttcttcgga 3471661 gataagctgt cgtaccgcat ctgcagcatg gtgtgccgcg gaacaaaatg gatagatttt 3471721 aaaccataga cccggctgca caattctcca cggtgccccc caatcgttta gcaaagtgtg 3471781 ttgtgctttc tcaacgtcac cgtacagact gaagaaacca gtttctccat caagtgccgt 3471841 gcgggacccg ccaaattctg attgggccag cttaacggcc agcaagccag cctgagccgc 3471901 caaaccggcg tgcagcggtt tcatttctgt tccaaattgc accctcatcc cagcagattg 3471961 cgtagccgca aaaccaattg ctttttccaa ctcttcctga gtcagctcct cagcataacc 3472021 tacggcgcag gcagcagcga tggcaccaag cgtacctgta ttatgccagc ccttctcata 3472081 gtggcggctg ccaattgatt ctcccagccg tgccatcact tcaacaccaa caacataagc 3472141 gccaagaagc cgctcgtcat gtccgcgagc ggcagaagca ataagggccg gtacgatgac 3472201 tgcactgggg tgtcctctta catcggagtg gacatcatca aaatccaatg catgggcgat 3472261 aaatccattg agcatcgcgg attgtaatgg cgcggccttt ttgccctgtc cgataacagg 3472321 aacaaggggc cggcctcctt catcctctat cagacggagg agcttttgaa ttcctttatc 3472381 ttctcttcct gcgaatgaag cggcagtaaa atcaagtaat cccttttttg cttcgtgaat 3472441 cgcgtcaact gaatgctcag gttgtgacgt tctcacagcc tctgcaagac ctgctgtcag 3472501 cccttgtttg ctcatttgat ggtctccaat acaataaccg ccagctccgc aaagtattga 3472561 gaggcaaccg taagggcttc ttcatccagt gtaaaggccg gatgatgcca ctcctccgtc 3472621 ccgttcgttc ccatccagac aaaaaatccc ggaatcttct cttgatacag agcgaagtct 3472681 tctccgcccg gagactgctc agcgtgaacg gtttgatagc caagccgtgc cgcagcttcg 3472741 gatgccgcat tcaaaaatgt gccgtcattc tgaacggaag gcaaataagg aaaccacttg 3472801 aattctgctt gtgccccata gcccgctgca attccttcag ccactcgtct catatgctcg 3472861 ggaacagcct gcctcgcttc tttttgaaag gttcgaaccg tcccctccat ttcagcttgg 3472921 tctggaatta cgttccacga ggtgcccgcc tgtactcttg tgatactgac gactgcgttt 3472981 tgcagtgagc tgatattgcg gctgaccaca gattgcagcc cgctgatgat ttgtccggct 3473041 gcagcgattg gatcaatact gttatttggg atgccggcgt gcccgccttt ccctttgatg 3473101 acgatctcaa atcggtcaac acttgccatg agcggacctt cctttacacc aatggtcccg 3473161 acaggcagat ccggcttatt gtgcatgccg aaaatcgcag aaacgccatt aagtacgcca 3473221 gcttctagaa cctttcttgc tcctgcggca atttcttcgg ccggctgaaa gataaagcgg 3473281 actgtacctt tcagctcggc ccttctttga ttcagcaaca tcgctgtgcc aataatagaa 3473341 gcagtatgaa aatcgtgtcc gcacgcatgc attgtgccat caaccttaga tgcaaatgga 3473401 agattcgtct gttcttggat cgggagcgcg tcaatgtccg ctcgtattgc tatcacgggg 3473461 ccgtcttccc gtcctttgat ttctgcaatc acaccagtct tcaattgagg gacatcaagt 3473521 atttcgattt gctcctcctc aagccaacgg cggatttttt tcgtcgtttc aacctcttga 3473581 aatgacagtt caggatgttc atgaagatca cgccgcatat tgattaaacg ggtatgaaac 3473641 gctttgtcgg ccattgttct tctccccttc ttatataagc tctgcaggct ctcccacctg 3473701 cttgataaat cgtttcgtcc gttcgttttt cggatggtca aacagttcct ctggcgttcc 3473761 ctgctcgata atatggccgt ctgccataaa aatcacttga tcagcaacct cttttgcaaa 3473821 cgccatttcg tgtgtaacaa tgatcatcgt tgtttgtttt tccgcaatgg acttgatgac 3473881 ctgaagcacc cctgtgacga gctcagggtc aagcgctgac gttggttcat ccagcaaaat 3473941 cgcatgcgga ttgaccgcaa gcgcccgcgc aatgccgatt cgctgctgct ggccgccgga 3474001 cattgtgatt ggatagctgt cagccttatg ctccagaccg acttgtttca gaatctccat 3474061 tccaatacgt ttcgcttcgt cgcgtggttt atgttgagcc acgattaaag cttctgtaat 3474121 gttttgcaga gccgttttat ttttaaacag attgtagttt tgaaagacca tggccgtttg 3474181 ctggcgaagc cgatgtgctt ccttgcgtgt aaacttttcc gcattcagtt tggcttctcc 3474241 gatttcaata aggccttgat ccggacgctc taatagattt aagcaccgga gaagcgttga 3474301 ttttccggaa ccggacggac cgatgattgc caccacttct ccgcgtttca cttctagatc 3474361 gattccgtcg agcacgacga gatctttaaa cgctttgcga atatttttta ctgttatcaa 3474421 ctgatttcac ctctaagtcc ggtatggctt gctcatggca cgttcaaaca agtcctgcaa 3474481 aatgctgtag ataatggtaa gaacccaata gacgatcgca accgccaaat acgtctcaaa 3474541 atatttgagg tttcctgaag cgtacatctt cccttgggcg aacatctcca tgacccctaa 3474601 tgtaaaggcc agtgacgttt ctttcaggag cccgataaat gtattgcccg ttgccggaat 3474661 cgcatttcgg atcgcttgcg gcaaaataat ccgtctgtat gcctgaaatt ttgtcatacc 3474721 gacagacagg cacgcctcca gctgcccgtc atcaacagaa ttgagggcgg cccggaagat 3474781 ttctgccaaa taagctgcgt tttttaagct taacccgatg atggcagctg tgagagctgt 3474841 cattttgctc atctctggaa atagctgcgg cagcccgtaa tagattaaga acagctgtac 3474901 aagtgtcggc acgcctcgga aaaaggatat atacagcttt gacagctgat gaagcactgg 3474961 aattttgttt tttgtaatga gtgcgagaat aagtcctccg ataatggcaa aaatcatagc 3475021 tgctattgcc ataaacaagg tgatcggaag ggcctgaatt aaagtcggga acgctgatat 3475081 catgaattcc caatcaatcg tgttcattct ggtgagtcac cgccgtttct taatgcttct 3475141 gttctactgt gatatcttca ttaaagtatt tttcagagag ttttttcagt gttccgtctt 3475201 tacgcaattc atctagggcc ttattgactt ttttgcggag cttgtcgtgc gcatcgtcct 3475261 tggcaaatgg gaatgcaacc tgttcgtaaa caatcggatc tcctgcaagc tttaatggca 3475321 aaccggtctt cttgatttgc gcgatcaata cagttcggct gttgacataa gcgtctacac 3475381 ggccgtacgc aacatccttc agcgtaccct cttgtgtttc gtacgttttg atattgattt 3475441 ttttatcagg atctttgctt tcaaggtttt tcgcgtggtt tgaaccgaga acggctgcga 3475501 ctgtcttgcc ttttaaatcg tctactgatt tgatgtctgt attgtctttt ttgacgacaa 3475561 tctgtgttcc cgcataagcg tatggtttcg taaagttata cgtttcctta cgttcgtctg 3475621 tcacagctac ctggttggaa atggtgtcaa gcttgcctgt ttgaagctct cccatcagcc 3475681 cgctgaattc aagcagcttc cagtccagtt tcatgtcaat tttcttagcg actgcttcca 3475741 tcacttccac gtcaaagcct gtcagctttc cgttttcttt ataagcaaat gggtaacttt 3475801 gtcctgtcgc accgacatga agcacattgt catcctcttt actgctgctg tttccattgc 3475861 cgcaagctga gagcaccgct aataatgcag caacgaccag cactgtccat tttttcatct 3475921 tcatttgatt ttcccgcctt ttctattttt atagatcatg tcgcaattgt tttttcatat 3475981 agactgtgat atgccctttt ccaaggtctt gttcacctga gcggacatat ccttttcgtt 3476041 cgtacatctc aatcagccac ggatgcttat ccgctgttcc gagtgagaca aacggaacct 3476101 ttaacgtatc gcgaaggatt gtttcctcca gccattgaag cagctttgtt ccgattcctt 3476161 ttttaccggt gtcggggtcc acagcaaacc accagatatg cggaacgcca tacggtcccg 3476221 gctgttttcc ccaaggcatt ctcaaggtga tggtcgcgat gatccgcccg tcttcttcca 3476281 tgacgtagca agcattttcc cgaatatttt tcagcaccaa atccaaatcc gcatgagcag 3476341 cagcaaaacg aatgccgagc tttcgaatcg gttcataagc ccgcaatgtc agctcgagaa 3476401 gctgttcggc atcacgttca actgcaaggc ggtatcgtgg cttcatctag cgttcctcct 3476461 tactttgcat agcggtttac cggcttttcc aaaccgaagt gctctcgtaa tgttgtgcct 3476521 tcatattctt ttctgaacac gccgcgctcc tgtaaaatcg gaaccacttg atcaacaaac 3476581 acttcaattc cttctggaag aagcggaggc atgatgttaa acccgtcaca cgctttcgta 3476641 tccacccatt cctgcatctt gtcggcgagc tgctccggcg tgccgacgaa gatatggtgg 3476701 cctctggagc ctgcaacgta tttgtaaagc tctcgtatcg tcatattgtc acgttcagcc 3476761 atctcctgaa caagcttgaa gcggctcttc accgcattgg aagcttcggc gtcaagcttc 3476821 ggcagcggcc catcaagcgg atatgccgac aaatcaattc cgcctaagta attttggaga 3476881 atttgcagac cgacagatgg gataatcaga tcttggagct ccttgtattt ggcttgcgct 3476941 gcttcttctg tatcggcaat gattgggaaa atacccggca taatggcaat tttttctgga 3477001 tcacgtccga attccgcagc ctgttcttta atggattgat aaaattcttg agctgattcc 3477061 aggtggtttt gtgctgtgaa gatcacttcg gctgttttgg cagccagcgc ttttccgtct 3477121 cctgatgatc ctgcctggat aatgaccggc tggccctgcg gggttcttga aacgtttaga 3477181 ggtccgcgaa ccgagaaata ttctcctttg tggttcagct catgcatttt ttctttgtca 3477241 aagaattcac ccgtttcttt attacggata aaggcgtcct cttcccatga atcccaaagc 3477301 ccctttacaa tctcgacaaa ttcctctgcc cgctgatagc gcaaatggtg ttcaaggtgc 3477361 ttttcaccgc tgaaattcag cgctgttgat tcaatagatg aagtgacgac gttccatccg 3477421 gcacggccat tggacagatg atccaatgac gcaaactgtc tggcaatatg gaatggctcg 3477481 ctgtatgtag tggaggctgt tgctgtcagt ccgatttttg atgtgacctg cgccaaagca 3477541 gagagcaggg tgaatggctc aaaccttgtt aatacatttg gatgtgattt gctgtcaatt 3477601 gaaaggctgt ccgctaaaaa cagcatatcc agcttgcctc gctccgctgt tttcgcaagc 3477661 tctttaaaat aatccaaatt catgctcgca tctgacggcg cgtccgggtg ccgccaagac 3477721 gcaacatgat ggcctgtacc tgctaaaaat acccctaatt tgatttgttt ctttttgctt 3477781 gtcatggcga tactcctttt atcatgtttt taggctgaat aatccgaaaa ataaactcct 3477841 atattcctag tcgtttaata tgaataaatc aaaatgtacc tttgtcttgg acgtttgtca 3477901 atgagttaag attaattttt tctattcaag cgaaaagacc cttgcgtgac catgagggaa 3477961 cggcattgat tcattcaact agtgcaacct ctatatcggc aagaaaactg agtctaatga 3478021 agcaaagact cagttttctt ccaataattt catataagat ttcgccattt cctttgcctt 3478081 ttcttcgctt ttgcaaaccg cctatccatt cagacgccgt aacgattgta taaaaaaaca 3478141 gctgactcca gatattcaaa ccggaatcag ctgattgatg tgaattaatt aagctcatga 3478201 atactctctt ctgctttagc ggaaaacact ttaggctcca aacagtcaag gtcttcatga 3478261 aataaattta ctttttggat ttgccgattg tcatagtggt ggaaatagta gtttccagtt 3478321 tcgttgcaca tcacggaagt atattgcgta taatgaattt cgtcttcttc cgttatcact 3478381 gcgccctttg gtatcgtcat atttgccaaa atttgaaaag cggctgttac acctttcgtt 3478441 tcatcggccg ccggctctag atgttctttc aaataaacag ctctgacaaa ccgggaaggc 3478501 ggtgtataat cccccggcag accaacagtt cctaagcctt ggccaaaagc agaaagggct 3478561 aatccgccca tctctttgct ctctaattgc ttcggtctga ttcctgtata ttgctgcaga 3478621 ttggttacat gccatataaa gtcggggctg ttcgtcatga caccaggttg attatcatag 3478681 actttgaggc cgtctgctct tggttctatc gtcaggtttc ggcccgtccg gtctgacaat 3478741 atccagtgaa gcggtaaaac tgtatccaat agatctaatt ttttctctac aatcgttaaa 3478801 gatcgaatct tttcttttac gtcttccaaa gactgacaga ctgacagcac ccatgtcaca 3478861 aactcatgcg ggacaatgtg aacggtatct tcccgtatcg ttttttcgta ctccgcatag 3478921 cccggaaaat aaagcgccgc acaagataaa ccgctttcat taatgccgtc ggcaaataat 3478981 atatttccaa gttttctccc cataccgata aacgcgtact gtgtctgatg ggcccttccg 3479041 tcagcttcac tgttccagct gtaacggcgc ggatagagaa tcacctctgt ccccagctga 3479101 aatgcaaaat ccattgttct tgctaataca tgtttacggt cagcagtttc caatgtaaga 3479161 cttgtgcaca tttgatcagt ccccttttca attcagatta atatcataca tattgtgaac 3479221 gaattggttt tatcagcata acgaaagtca aatcgattcg tcaaagaatt gacattacat 3479281 caaataaaac gaaaaaatcc agcctttaga aggctggatt ttttattatt tagccaaaac 3479341 aagctcgtga atcgcatgtg caacgccatg ttcattattg gagcgtgttt gaaagtttgc 3479401 tgcttccaat acttctggga tggcgtttgc catggcaacc ccgcagcccg cccattcgat 3479461 cattgtcagg tcgttcccgt tgtcgcctat gcacatgact tccgcctgtt caattccaag 3479521 cagctgagcc agctggcgta cagcatttcc tttgctggct tccgagtgca gaatttcata 3479581 aaagaaaggc gcgcttctga ccattgtata tttttctctc acgtcttttg gaatcgatgt 3479641 aatgacgcgg cttaagttct ccggtttatc aataaacatc actttcggga tgaggatatc 3479701 ttttggcacc tcgtcaatct tgcggaaatg aagcggcacc tgtgtcacat aggattcgta 3479761 tacggtaaat tcgctaatat cccggttagg cgtatacaaa ttagatgagt caaagaaatg 3479821 catcggcgtc ttcagctcta agctcaggtc atataatgaa gtcaaatcat cataaccgag 3479881 agacagctct gagaccactt catttgtatg cgtattttga acaagtgctc cattatacgc 3479941 aataacatag tcgccttctt caattaaatt cagttcatct aaatatctct gcacaccccc 3480001 gataggccgg ccggtgcaaa gcacaatttt gacaccttcc gcttttgccg cgtgaagggc 3480061 gtcgcggacc tcctctgtta cttcatgatg atcatttaaa agtgttccat ccatatcaat 3480121 tgcaattagt ttgtacatcc tgcatctcct tcatgtcgtt ttcaggctat agtcccatca 3480181 tatcgttttt tctttttgat attcaaccgg aagagatggt tttctccgga ttctgtttag 3480241 acgccgccct tgtcttcgga tacgcaagcg cggtttccgc tttctttctg ccttgacgcc 3480301 gttttctgct tttttctgtt tcatcagcag aaagccggca gctagaaaag gaatgccggt 3480361 tatattcaag atggcaagct tcacacccgc cgcgatgaaa aagaaccccc atgaagatga 3480421 tggattccgt ctgatcatga cgtaagccgc catttccaga acgatcagga tggcatgaag 3480481 cactatgcca taaatcagca atacaagggc aaaaaacaaa acataattca cgattgcccc 3480541 tgagtacatc atagcgcgca tcatttgtat aaacgataag gactgcatgg agccgctgat 3480601 gacattaggg ttatagatcg tatagtcact aaataaatgt ttgactttga gaaaagccca 3480661 taatataaat atccattgaa tgatatgtaa aacaagcccc gctgccacca gtctttcagc 3480721 tttttgattt ctcatctttc tcctccctgc cggtctttga ttcgattctt gtcatcgttt 3480781 ttctctgtcc attttgctcc catatcaatg tcccgttttc tcctcttttc agcgtgcttt 3480841 tgagcggata ataagggccg aggtactgaa tctcgataga cccgtcagtg ctttgggaaa 3480901 tcaccttgta tgccataaaa ggcagctgta cctctcctct tccttccatc acttccgttt 3480961 ccacaacctc gtcttcggta aatgtgactg ttgctgattt cacaccgtcc gttggcccgg 3481021 gggcacgccc ctcatcccac gttccgtaat aaaacggcgt ctcttctttt tgctgctggc 3481081 agcccgatac catgatgcat acagcaatta aaaacaaaat gccatatttg tttctcaagg 3481141 ggatcaccat tctttcctcc ttttttgggc gaatgccgtg ccactgtgcc aatgactaca 3481201 taagttataa ggaattcacc cacaaggaga ctgatcacat gaacccttat caatattaca 3481261 gccctcagct gcctcagcag gaaccttact atagccacta tgagtacaat ccttatccgc 3481321 agcaggatgt atacgatcca taccaaatgg acagacagcc ggcattggaa agaagaatcg 3481381 cagcacttga acggcaaaat gaacagcagt caagagaatt aacccgtctg acaaacgaag 3481441 accgccgtca aaatcgggaa attgcacgga ttgccgaaca ggtcaatcag ttaagccagg 3481501 ctgttgaacg ccatacacgc cgcctaaatc ggctcaatca gcgcctccgt acagtagaaa 3481561 accggctgaa tatcccattt actgcagggg aaggcggttt ctgagcgaaa caaagaaaaa 3481621 aagcggaata cgattctccc atctcagggt ttcgttttcc gcatttctta tatgttaaaa 3481681 cggaacattt acataaaaag ggtttgtacc cagtatacaa tctttaccgt tttcattcaa 3481741 agatagaggg gctgaggaaa ataattgtag ttcctctttg acggaatttc ttttcattca 3481801 agttgcatga taataccgac tcacgtcaat cgatacatgg agggatcatt catgcataat 3481861 acacaacacg gcttgcagca gctgaaccaa tgccgccaaa ctgctcagca gctcattcag 3481921 caaacacagc aaagcagcca gcaatatcgc caaatgcttc atcaggaaca gcaaaacatc 3481981 caaatgctgc agcagattct aaaccacgaa caacaagctg cacataccat tcagcaagca 3482041 ctgcacgggc atgacatggc gattcaaaag tgccagcagg ttgtcaacat gtgcaaccaa 3482101 atgcaacagg aacttactgg acaatccagc gtcatgaata cgaatgtgtc tacacttcca 3482161 ttcggccaaa acacgacatt tcagcagcaa tcctaccagc agtaacatat aaaaagctca 3482221 acacaatgcg agtgttgagc tttttttctt actgttcttt gcgaatatgt atatcctgaa 3482281 tagactgttt cggtgcatga aatctgctct cggcttcact tcttgcctcg gcaaaagccc 3482341 gcgcctccac atgatctttg tagacatcca gctgaatcaa atacagcggg cgcactttaa 3482401 atccatgaat aatggttacc gcccataacg ggaccacaat aaaaacaccg ggcagatcgg 3482461 gcaaaacaaa accaaacgca aaaatgaaaa aataaatgat gccgtacatg atccactttc 3482521 tatttctaac cttgatgcca ataaataaaa aggcaaaaaa actggtaatg gcaaaaggca 3482581 tgaaaataaa cagcatccac cagctatgca gccattccca agcggcacct ctttttgtaa 3482641 ttcccatatt tttctcctcc tatttaccta taataatcga ttaggcacac cgcgtcaccc 3482701 ataaacggga aaaactttct cccttaaaaa tagtgataga cggagaacag gtttcttgct 3482761 atattattaa ttgataatga taatcattac taatctattg agatacatag tgggagggtt 3482821 cttgatgaaa aagaacatat tgctcgtggg catgcttgtg ctgcttctca tgtttgtcag 3482881 cgcttgcagc ggcacggctt ctaaagggag ctcaagcgat tctgcttccg aaaaaacaga 3482941 aatgagaaca tacaaatcac caaaagggaa cgtcaacatt cctgcacatc cgaaacgcat 3483001 cgtcactgat ttttatgccg gtgaattgct gtctgtcggg gccaatgtgg tcggctcagg 3483061 ctcatggtca tttgataatc cgtttttaaa atcaaagctg aaaaatgtga aggatgttgg 3483121 tgatccaata agcgttgaaa aagtgatgga gcttcagcct gacttaattg ttgtcatgaa 3483181 tgaagagaat gttgataaat taaagaaaat cgctccgact gttgtcatac cttataacac 3483241 agcgaaaaac gtagaagaca cagtcagcat gttcggagat atcgccggag cgaaagacca 3483301 agcaaaatcc tttatggctg actttaacaa aaaagcggaa gcagctaaga agaaaattgc 3483361 cggcgtcatc gacaaagatg caaccttcgg catttatgaa aacacagaca agggcgaatt 3483421 ctgggtgttc aatgacaatg gcggacgcgg cggccaagct gtatacaatg cacttgggtt 3483481 aaaagcgcct gaaaaaattg agcaagatgt catcaaaaaa ggagagatga aacagctctc 3483541 tcaagaggtt attcctgagt atgccgcaga ttatatgttc attacggatt acaacccgaa 3483601 aggcgaaagc aaaacactcg acaagctgga gaattcctcc atttggaaaa atcttgacgc 3483661 tgttaaacat aatcgcgtgt ttatcaatga ctttgactcg ttctacccgt acgacccgat 3483721 ttctgtcagc aaacaggtgg atatcatcac cgacatgctg atcaaacggg ccgaagaaaa 3483781 taaaaaataa aaaaacggca cagtcatgac gctgtgccgt tttttatgat tcactttaat 3483841 tttgactgta cggagtccgg catatcttca aacttgactt cttcccaagt ctcgacatac 3483901 tttcctttcg ccttcacctt caaatacgcg ttcttccgaa gctctttgcc ggcgaaaaag 3483961 gtcacttctt cttttttccc ggatgcatta tatccgtcta atgtatattc agtaccgccc 3484021 ggactaagat gtctgccatc tcgatcaatc tgaacataga catcttgctg gtgaataaac 3484081 ggattaaatc tgtctgtaac atcgttatga aaaaagagaa gcccgcatat tacggcagca 3484141 gccgccaaga cggccaggat tgccattgct tttttcatct ttgcactccc cttacttgtt 3484201 catttttttc aaatagcttg accgcaccgc gaggaagaat agaagctgaa aaatgaaaaa 3484261 ccctccgatg gtgagactga gcggccccgc tacatcggaa tatccttcca cagccaatgt 3484321 tctcaaggca aacagtgtat gcatgacggc aatgacaaat ggaaagaaga aaagaatcgc 3484381 caattgtatt gtcacgcttt gcgccatttc tcgctcactc aggccgattt tggccagtga 3484441 acggtagcgc tcccggtctt catctaaatc agtgaacagc ctgaaatata agaaacttgc 3484501 tgccgcgaca aagaatacaa ttgcgataaa caggccgata aatagactca ggctcggcag 3484561 ctgcaccgta tcatagtaag tccccgcttt tgaagcaaaa tcagaatgca cgtcgatata 3484621 attgccgtaa atctcatttt gcaaggattg gctgatctca agactgtctt tccaatgatc 3484681 atagctgtag ccgtataatg acgctttatc accgagtgat ttcagctgat caaaggtttg 3484741 atcattcacc gcgatgatag cattcaatga gatcagcggt tttttgactt cttttaccga 3484801 cagtttttga tcagacagct cccctttttg gttcagcagc ttcagctgat ccggcgcttc 3484861 gtttttgaaa ttgcggtcat acgttcccgg gaaatagaca gcctcgtctt ctttcaggcc 3484921 gttcactttg acatggaagt attttgccgc atccgattca ctgatcatgt aaacaggggg 3484981 aacagtttct ccttcctgat agcgaacata ggaaacatct attttgtctt tcgtatacgt 3485041 aaaaccgtgt gttttcagtt catggtcaat atctttcaaa tgagtctgtt cttttggatt 3485101 gttgctgtaa gataaatact ccatttcata agcggactct tccgctccga cggtcgattt 3485161 gtacattgcg agcacgcctg tcgcagtaaa cgcaaccgcg gaaataatgc tgacaataaa 3485221 gaacaggcgg gcgttgtctt ttagacgata gacaaggtca gaaacccaaa tgatgttttt 3485281 cccgcgcaga taaaaggttt tccacttctt cagcgcgcgc agaatccata tgctgctttg 3485341 gctgaaaaag aaatatgttc cgataacggt gagcagtaaa atgataaacg gttcggcccc 3485401 gtggacattg cctttaagaa ccatgccgta cccgccgcac agacaggcga tgccgaataa 3485461 ggacagaagc acggacggct taggctccgg tttaaccttg ccagtgccct ttattaattt 3485521 gataaccgta tttgatctga caaaaaggat cgtaaactgc gataaaaaga aaaataagag 3485581 cagaaatccg caggccgtaa taccgagcgc tttccaaggc atatacaaag gcagcgcgtc 3485641 catttctaaa atataagcgc cgaccgtaaa gaacgtcttt gaaaaaatga atcctccgat 3485701 aataccggct gcaattgaca tgacgccgat gatcatattt tccgcagtaa tgagctttct 3485761 cagctgcccc ggcgtgatgc cctgcatgag cagaatgccg aattctttat ttctcgattt 3485821 caaaaatgca ttaaccgaat acagaacaaa taagaaagaa aaaacaaaga tcatccattc 3485881 cgcggcggtt aagccttttt tggcgatgtt attcaggtag ccttccttta atgccggatg 3485941 aaacaggaac atcgcaaagg taaagaaaat caaaacggaa aaggcgctgc ttaaaaagaa 3486001 tgcaagatag gcccttttgt ttctcgtgac gtttttataa gcgaactgaa gaaaggtcat 3486061 ttgcgtttcc ccccagcata gacagcacat cgagaatttg ttcataaaat acttggcggt 3486121 tttccccgcg gtaaatctca ttaaacagtt cgccgtcttt tataaagatg acgcggcggc 3486181 agtagcttgc cgaaaccgga tcgtgggtca ccatcaaagc cgtgacatga tcatcccgat 3486241 tcaggctctg caacgtttcc atgacgtctt ttgtcgcttt ggaatcaagg tttccagttg 3486301 gttcatcggc cagaatgagt gacggcttat gaatgaccgc tcttgcgatg gcggcccgct 3486361 ggcgctggcc tccggatact tcaaacgtcc gcttgttaag caggttttcg ataccgagct 3486421 ttgccgcgat gccgtgcagt ttttcttcca ttacagacgg cgcttctttt tcaagcgtta 3486481 acggcagcat gatattttca ccgatcgtca gcgtatccag aaggttgaaa tcctgaaaca 3486541 caaatccgag ctgcttgcgg cggaaatgag cgagctttgt ccgcttcagg cgatgcgggt 3486601 tttctccgtt aatcaggata tcgcctgaat ctggacggtc aatcgttgaa atgatattca 3486661 aaagcgttgt ttttccggac ccggacggcc ccatcaccgc cgtgaactcg ccttcttcta 3486721 ttgaaaatga aatttgcttt aaggcctgat aggacacttg tcctttatag gttttattta 3486781 tatgtttgac ttcaagcata ttcgccatga aaatcctcct tatggtttta ttcttgttga 3486841 tctgggctgc tttcatgtag tgccgggacg ttcaacataa aaatcccctt gacataaatc 3486901 catgttatca aggggaaaca aagcgggcta tgttgttttc ttaacgcagc cttacatttt 3486961 tgtaagaaat gaaaatcgaa ctgatgtccc ttcaccggga gacgagctga tgtccaccgt 3487021 atgattgagc ttatctgtaa tttctttgac gagatggagg ccgattcccg tagattcttg 3487081 gaaacgccgc ccgttttcac ccgtgtaata agggtcaaac acccgcttga tgtcttgtga 3487141 gggaatcccg acaccgtaat ctttgacttc aagcaccgtc ctgtcttcat cgcagaagac 3487201 attcagctca agtctgtcac tcttgcccgc tgaatacttg accgcatttg tgaccacttg 3487261 gccaatcgca aatttgagcc atttggcatc ggtgtaaatc tgatgatcat cgcaaacgtt 3487321 cattttcgga taaacgcgat attgaataaa aaatcgttta tagctttgaa taactgattg 3487381 gagaagctcg gacagggaaa ccgcttcgat tttaaaatcc cgttcaaaca ggtcgagcct 3487441 tgaagaataa agaagcgtct ccagcccgaa ttcaatctgc cggacttctt ttttgatttg 3487501 ttcaaaaacg ggctcatcct cttcttgaat gattaaatta atgaccgaca gcggcgtctt 3487561 tacttggtgc acccattgat tcatatacgt cacccgcgcg tcaagcttgg cttcggtctc 3487621 atggagcttc tggtgctgca gccggatcag ctccatctgc ttttcataca gctctgaaca 3487681 gaacactgaa gaaccgagat acgggatatc cgtcccttcc tgccccgagc tgagccaatg 3487741 atacacgccg cggtctttgt accagcgata ggcaagatag cccgccaaaa taagaagctg 3487801 cacgcccaat atgtaaaaca agtgagaaaa agaatgaaga cccgcaaacc agtaataaaa 3487861 gaagacaaac agcccttgaa ggagaaaaag cagaatcagc actgcatgag accggagaaa 3487921 cagcttcatg actgcgccct cagctggtag ccttcgcccc gcaccgcttc aatagaaaca 3487981 ggcgcattca gctcccgcag tttttttctg agccgcgtga tatacacgtt aagtgtatta 3488041 tcatcgatga atatgtcggt gtcccacgtc ttttccatga gacggtcccg actcgtcacc 3488101 ttttctcccc gctcaagcag cacttccaaa agcttgcttt cttttttaga aagctcactt 3488161 ttttcatcct gaaaacgcag ttcaaaccgt tccacaaaga gctgaacgcc ggcatattca 3488221 accactttct ctccctgctt tgcggcgtac tccccgtacg ccctccggat ctggcttttg 3488281 attttcgcaa gcacaatatc ataagaaaac ggtttttcga tataatcgtc tcccccattt 3488341 tcaatcgcca tcacctgatc catttccccg cttctggcag aaataaagat gatcgggctt 3488401 gtggagtgct ggcggatctg ccggcaccaa taatatccgt catatgccgg caaattgata 3488461 tcaagcagca ccacatcggg cttttcccgc aaaaagacat caagaacagc tgtaaaatcc 3488521 gcggcgacca ctgtttgata tccgtatttt tcaaggtaat tctgcaatag tccgcgaatg 3488581 tcttcactgt cttccacaat catgatttta ttcaaactga accactcccg tttcttacac 3488641 tgctgccatc atcataatcg ttttgggcgt atggacgcaa caccgcacaa aaaaaccgcc 3488701 atctcggcgg tttctggtct ctttagccga cctgctgctt agctgcttta ccggctgatc 3488761 cgaactctct cattttgctt cgcactgtct cttccacggc ttcaatgccg ggtgtcaaat 3488821 agccgcgcgg ttcgtacaga tcgctgtttt cctgaaacat gcggcgtgtt tcgtctgtcc 3488881 acgctaccat acattccgta ttgatattga tcttcgcgtg gccgagcgtg atggcttttt 3488941 tgatctgatc ctgcggaatc ccggatgccc cgtgaagaac gaggggaata tcagtcatgc 3489001 gggagatagc ctccatttcc ttaaatccga gattcggctc accctgatat ttgccgtgta 3489061 cagagccgag ggcggcggcc agcgcgtcga tattggtttc tttaacgatc cgctcacatt 3489121 ccgtgatatc cgcatagcgg accccgccga ccagtccgtc ttccattccg ccgaccgtgc 3489181 cgacttcggc ttctactgac acgccgtgtt ttgcggcata atcggtgact tcttttgtca 3489241 tcgcgatatt ctcgtcaatc ggctgatggg agccgtcaat catcactgag ctgaatccgg 3489301 catcaatggc ctgtctgcag cgttccgcac tgctgccgtg atcgagatga agcacgaccg 3489361 gaacggtaat cgccatgtcc tctattaacg cgccgaccat ggcggcaatc gttttaaatc 3489421 cgcctaaata gtcgaccagg cgatcggaag ccgcggcgat gaccggtgat tgctcctttt 3489481 gcgccgcctg caaaatcgcc ttcgtccatt gcaggccgtt gatattaaac tggccaattg 3489541 catattgctc ccgctttgca tcttcaagaa gctctttcat cgatacaaaa gccatattca 3489601 cccctccttt atccattaca tgctgaagta ttttgatacg acatccactg ttgttttttt 3489661 cgctgtttga atggcttcct cagcagtcag cttatagtat tcaggccgga agagctcaac 3489721 cgaaacaaca tcagagaagc cgatttcctt cagtgctgat aagtgggcat ctaagtcaat 3489781 tgccccttgt cccggccata cacgatcctc atctgttaaa aagccgattg ggaaatcttc 3489841 tgtatcatca atatgataga tgaagatttt ctttccgtcc gcctgcttta agctctcaat 3489901 atttgaaccc attgcatgga agtgaaaact gtcaaggaca agcccgacat tgtcacggtt 3489961 aactgtgttt acaatctcat acgcctgttc aaacgtattg accgtacatt gcggatggcc 3490021 gacaaactca agcgcgattt ttacgccgta cggctccgcg atatctgaca gctcagtcag 3490081 cacgtctaca ctgctctttt tgatctcttc ttttacaatc ttctgctctg tcacaagcgg 3490141 aacggccacc acatatttca caccgagggt tttgcatgtt tccatcatgc ctttaaattc 3490201 agtgatgatc tcgttgtgac ccttttcatc acggttgttg aagaaaacga gtgcgtttaa 3490261 ggcaagcggt ttgatgtggt gggtttgaaa atattccgca aggtcatcca atgaatgatc 3490321 ttttaagtac tccggcagct tatccatagt acggatttca atataatcat agccatgctt 3490381 ttcgcatagt tctaaatcca gtttaaggtt tgagttttcc aatgttgtcg cttcattaaa 3490441 acaaagtttc atgccagact cccccatctg cgttttagat atgaagggag ttcggcagga 3490501 aggctgtcgc catatcccgc cgaactccat gctcagctta tgccagacct aattcttctt 3490561 tcattttctt aagcataaat cggcttgatt catccgctct ttcatcgacc caagcaaata 3490621 cggcattcgt cgcaattccg tcgaacttca tctctctcag ttttctgaaa atcgtatcaa 3490681 aatcaacctc gccttggcca atgtccaaat gctggtgaac cgttactttc gcgtcaggcg 3490741 gattgacgat gtagcgaagg ccatgagccg ctttatgatt ataggtatct gcaaataaaa 3490801 catgtgtgag gcggtcgccg gcttcgtcaa acatggtctc gatgtcgcct ttgccgtcat 3490861 catagaagaa cgtatgcgca gtcgagtaga caagattgat ccaatccttg tcaagcgcgc 3490921 ggatcatatc catcgcacct ttgtgcgttt cgataaaatc atatggatgg gcttgaagat 3490981 tgagtttaat gccttctttt tcaaagactg gcagaagctc atccatggat ttgataaatt 3491041 tttcttcact tgttaaagga tcatattttg aaccgctgaa ttcgctgttc atcaaatcca 3491101 cttcaagttc aaccgcaatt tcgattgccc gtttccagtt gcgcactgct gcctggcggc 3491161 ggtcttcatc gggtcccgcc cagtggtaaa gaggaagaag cgatgaaagc ttaacacctg 3491221 tatctcttaa aaggcgcttt aattgtttga tctttgctga atcgactttc ggatatttat 3491281 aaaacgggca aaaatcctcg cgcggcgata attcgatata ttcatagccg agctctgccg 3491341 ttttatagac catttcctct aaagttaaat catcacgata catggatgga tccaatgcta 3491401 acttcatatt ttcactcctc tgttttttag ttttgaactg ttgtaaaaga ttgatagaat 3491461 tccggttttt ccttcaattc aaccttttct ttttgtccag attcctgggc ttttacacac 3491521 gcgtcagtcg tgacagcagc aatatagccg tcccatgccg tcggtccgct gacctcgcct 3491581 ttcttttgaa tcgaatcaat aaagtcttgg atttccacat catacgcagc gacaaagcgt 3491641 ctctgccaat ccatcaaaat atcagtgctg aatctgcctt cttttctcaa gctgatgctt 3491701 gatggctcgg gaagcttgat gatgccgtct tctccgacga tttcacattg aatgtcatag 3491761 ccgtatttac agttcacata gatttcagca ttgatgacga taccgccttt tgtttcaatc 3491821 acgacgattt gcggatcttt taaatgtgga agcgcgtttt ttgatttttt cggatagatg 3491881 acttgaacgg actcgtagtc atcattgacg agccagtgga gcacgtcaat ttcatgaaca 3491941 agcgtgtcga ctacagccat atccgttgta tagttatctc ctacagtcgg gttgcggtgc 3492001 gcgcagtgaa tcataagagg ctcgccgatg acatgattat cgagcgcttc tttcagctgt 3492061 acgtaaccgc tgtcataacg gcgcatgaag ccgacttgaa caaggcgttt gcccactttg 3492121 atttcttctt cgacaatgcg catgcatcct tcagccgttg tcgcgagcgg tttttcacag 3492181 aacacatatt tctgggcttt aatcgctttc agcacgcttg actcatgcgc aggcccccag 3492241 cttgtcacta aaacagcgtc tacattttcg tctgcaagca agctgtcatc attcggataa 3492301 accgtcgcgt ttaattggta ttgctcaacg accttttgtg cagcttcttg attaacatcc 3492361 gttacagcta caatttccgc gcctgacagc ttgttcgtga tacggttaat atgttctttt 3492421 ccgattgctc cagttccaat tacgccaata cgtaaactca ttgacagcca ctccttctgt 3492481 tggttacatg attttgcttt ctgttccttt ctttacttgg ctctgaggag acccgtagag 3492541 ttcctcttga atttgttcaa gcgacttgcc agacgtattc ggcgcaaaga gcagcccgat 3492601 gatcatactg gccgtcacac atccgagaag aattgcagcc atcgttccaa tgccgaaatt 3492661 ggtgataatc attgggacaa acagactcca aatccctatt gaaatacgga caaggaaaaa 3492721 catcagtcct tgtgcggaag cacgatattg cgtaggaaag atttcgctgg cccataactg 3492781 atagttcgct tgctgcccgg ctccgttatt gatgccgatc acgacaataa acaggagcag 3492841 aatcggcagg ccttcaactg gcagcagaaa cagtgtccac ccgatcaccg ccatgaaagc 3492901 ggcgattcca aatacggttt ttctatattt gtcggcaaag ggcatgaaga tcaaggcgac 3492961 ccccaatcct gtgaagataa acagccccat ttgcaaaagg ttggccatgt tggcagatac 3493021 accgccgacc tgctgataaa tgtatggcat aaagaagccc atgaccccgg cggctaggtt 3493081 ccaaaccaag tacacaccca tcaaaaacag gatgcttttt agatacatag gcttgagcaa 3493141 atcaaaatac gatgtcttat tcaatacagc cggcttctct gcctgagctt cctccggctg 3493201 attttttgtc tgccaggcgt ctgattccgg aagcctgatt ctcaggatgt acgtaatcag 3493261 cgcaatcaca agcagatggg caaatacgat tttattcccc aagagtccca agtcaccggc 3493321 cagtacggag aggagcagta caacgacagc gcccgcggcc caagcgactt gtgctacgcc 3493381 gcaatgcctg gcccgattct tctttggcgc attttccgca ataatggtcc atgacgcggt 3493441 tatgtcagcc cctactgata aaccgataat gatgtaaccg cttaacaaca tggggaaatt 3493501 aaccccgaac aaaaccaaac aaatccctag tgcataaacc agcatactat tggtataaac 3493561 agccttccgt ccgactttat cagccagaaa cccgccaagc agcgcgccga cagcggcaga 3493621 aatcgcattt gcgctcaacg cgccgagcag cccgatttgc gtatcggata gcttaaggta 3493681 actgacccat aatgataaac cggcggagcc tgccacaatt gaaccggcat caatatagtt 3493741 ggccaatgct gccgcgattg tccgtttatt gaaggctgaa tctccattgg tattgcccat 3493801 atgttcattc cccattaagc cagatccaac aactgctgat caatatagtt tctcgcaatc 3493861 aatgcatact ccagcgggtt tgcaacatcg gggtcttgtt cagcttcaat gacaatccat 3493921 ccggaataac tgtgcttcaa cagcagctga tatacttctc taaagtcaat gcagccgtca 3493981 ccgggaaccg taaacatgcc ttttaaaaat gattgccgga acgattgtcc ttcgagcctg 3494041 cattgttcca tgacattcag gcgggcatcc ttaaagtgca catgcttaat gcggccgata 3494101 tgcttctcaa gcatccccat gtaatcgccg tcagaaatat acgcatggcc tgtatcatag 3494161 aggaggtgta catgcgcagg gtctgttcct gccatcaggc ggtccacttc ttccgctgtt 3494221 tggacaccag tgccgagatg atgatgatag acaagcttca agccatgctg agcggcaatt 3494281 tcgccaaggt gattcagccc ttcgcaaagc cgctcccatt catcatccgt aaagtgcggc 3494341 ttctctgtga acacattttt ctccaagctt tgcacgctgt acgtttgttc agagacaact 3494401 gcgacatccg cgtttacttg ctgcaaatac tcacaatgca gggtaaatgt ctttgccgct 3494461 tcaccaagtc cgtcacgcaa aataaaactg ctgaaccatt ttcctgcaat gcgtaagttc 3494521 cgaagcttca gctctttgtt caggatggca ggttcgggga aaaagccccc gacctccgtg 3494581 ccttgaaaac gtgcgacaac gatatcactt aacaaatgct gaagtgtatt tcccgctcca 3494641 atttcaggca tgtcatcatt ccgccaccca atgggagcga ttccccacag gatttcattt 3494701 ttgcccatct atggtgcctc ccctctaata ctgcttcgca gattccagct ttttctcttt 3494761 tgcttcgtat gctttctgaa cgctttcttg ttcagatacc tctgccaccc cgacatgcca 3494821 ccagctgtca tagccgtccg tcattgtttt aggcagcacc ttcatttcaa ttaatgttga 3494881 tacatcctgt ttcttcgcat cctctaacgc agcttttaat tcttctactg tgtttgcacg 3494941 gtaggttttc gcgccgtatc cctcagcgac tttcgcgtaa tcgacattca ggatttggtt 3495001 gtcatctgtg cggaactcgc aatagtagct gccgctgccg tgatccattt gcaggttgtt 3495061 gatgcatccg aatcctgagt tgtcaaagag cagcacattg attttcttgt tgtactgaat 3495121 cgccgtgatc agttcagaat gaagcatcag gaagctgccg tctccgacga ttgaatacac 3495181 ttctctgtca gggtgggcca gtttaagacc gagtgtcccg gacacttcat agcccatgca 3495241 agaatatcca tactccaggt gatacgtatt cggaacatta gaatgccaca gacgctgcaa 3495301 atctcctggg agtgagcctg ctgaacagat gatgacgctg tcttcaggaa tcgtctcgtt 3495361 gattgtcagc aatgccgttg tttgcggaag ctccgtattc aacgcgtcag catattcatt 3495421 caggacctct tgagaaaagt gatttttgat ttccggatca aatgcttccc gcttaaacgt 3495481 cactttgctg agacgctcgc gttcagctag ccattcgtcc ttcagctccc ggatcgttgt 3495541 gccgaactcg ctctcatagc cttcaagcaa gccgtgcagt ttgccaagcg tcactttcgc 3495601 atccgccacc acttggaatg catcaagttt atacgcctgc attcggctga cgttaatgtt 3495661 caaaaacttc gctttatcaa aatcaaaagc ggtcttagag gatgtcgcaa aatctgtata 3495721 ccttgtgccg atgccgataa tcaaatcagc ttggcgggcc gctttgtttg ccgcaagtgt 3495781 acctgtgatg cccattccgc caaggttgtt cgcaaaatct gcctcaacgg tagactttcc 3495841 tgcctgcgtt tcaactaacg gaatgttata ggcttcagaa atggcaacca attcatcgcg 3495901 cgcaccggaa tattttgcgc ctccgccgac gagaatcaca ggttttttgc tggatttaat 3495961 cagctccgcc gcaccttgaa gctcgcgctc gctcggctgc atgcgatcaa tatagtgaac 3496021 ccgtttgacg aagaaacttt catcaaaatc gtatgcttcc ccttcaacat cctgagaaat 3496081 acaaatcgtt gccggacctg cttttgccgg atcagtcatg acttcaaacg cgcgcagcaa 3496141 actgctcatc agctgctcag ggcgcgtaat gcggtcccag tatctcgata caggcttcaa 3496201 tgcatcgttt gtcgtaatcg ccgcactgta ttcttgctcc atttgctgca gtacagggtc 3496261 tggctgtctt gtcgcaaatg tgtctgccgg aatcaagaga actgggatat tatttgccaa 3496321 tgcagtgccg gctgccgcca ccaagttagc cgctccaggt ccgacggatg tagacaccgc 3496381 atatattttt cttctcagca tttgcttgct gtacgccatg gccgcatgcg ccattccttg 3496441 ttcatttttc ccttgataga ctttcaaatg gcctgcatcc tgctcaagcg cctgcccgat 3496501 ccctaatacg tttccatgac cgaaaatcgt gaagatccct tcgacaaaag gctcttcctt 3496561 tccatctaca tggatgtact gctggtttaa gaatttaatc agcgcctgcg cagttgttaa 3496621 gcgaattttc ttacccacaa acgatcccac ctttactcga tctttttcaa ttatgactgt 3496681 gcttcaataa gctgttcgat ttcttccgca gtcggcatcg cttctgacga actgtgcttg 3496741 ctcaccacaa tggaggctga agcactgccg tatttcaatg ccgtttcaat gtcttttccg 3496801 ctgacaaggc catagataaa ggctgacgca taggagtcac cggccccaaa ggttttcagc 3496861 acttttgtct tgtacgcttg agcgcggaat acctcgccgg atttgctgta tgcgtaagag 3496921 ccttcgacgc cgtgtttgat gacaacgagg tcggctgaat ggccaaataa atgattgacg 3496981 gattcttcat tgcttccgcc tgtgcggttt tccatcacat caaattcatc gcgtgtgccg 3497041 atgacgatat cagactgctc ggcaaccaaa gaataataaa cggctgtttc atctgatgac 3497101 tgccacgtat atggccggta atccagttcg aataccacct taacctgatg ctttttcgcg 3497161 tattgaacag cttttaacac cgcttcccgt gacgggcttt tggcgagcgc tgtcccggag 3497221 acaagcagca ttttcgcatt tgcgatatag tcctcactta cctctgaagg ctcaagataa 3497281 agatccgcca catcatcgcg atacattaag atgctgcatt cttcagggct gaggatttct 3497341 gtaaatgcaa ggcctgcttt gtgtccatct tgatcaacaa tcatctgtgt agtatccacg 3497401 ccggtctttc tcatatagga ctctatgaat cttccatgct ggtcatccgg aattttgccg 3497461 atgaagcccg cttttaagcc aagcttcgcg ctgccgatcg cgatattcgc aggtgaaccg 3497521 ccgacatatt tcgaaaatgt catcgtttct tccattgggc ggttgtattc gactgcgttc 3497581 agatcaatac atgcccggcc gatggcaaca atatcaaaag ccttctcttc attgaatgta 3497641 tacttcatcg taaacagcca ctcctcactt gttagcgttc taaaatccat tcatgcgccg 3497701 ggtcgttata aaacttccat tttcgcgtcg gccctgccat gacatttaaa tagtaggatg 3497761 tgtatccgtc cggaacgcct accgggtggt atcccgcagg aacgatgaca acgttttcat 3497821 ttcccacagt cattgtctcg tcaatagaac ggtcatctgt gtatacgcgc tgaaacacaa 3497881 agccctgtcc cgggtctaac tcatggtagt acgtttcttc taagaaagat tcttccggca 3497941 agttgtcttg gtcatgtttg tgaggcgggt agctggacca gttgccgctg tctgtataga 3498001 cttcaactac taatagactg ttagctgaag ggtctgaatc cggaagaatg ttatgaacag 3498061 tacgtttgtt tgaaaattgc ccgcgatgct caattccgtt gtcttccgct ttgatcagct 3498121 ttgtcggaag ctgcttttcc gatggagaat agcaaagcgc cactcttgcg tcgctgaccg 3498181 ctgtgatctc aaatgcacgg tcatttgaaa tatagacgct gtctgtcggt tttcgttcaa 3498241 atacgctttc gcgcgtgccg atattctcaa aagtcgactc atgatctgtc actgtaattt 3498301 tccccgttac cgccacaata cagatttctt gttttttcaa ttcttctgta tagcttgaac 3498361 ctgatgcaag atctaacact ttaaactcta cataagtgag atcagagttg gatgtcgtta 3498421 cttcgtgcac gagtttgacc ccattagaca cttcatgcga ctgcggctta cgcaacaaat 3498481 aactcataga gaagccctcc tctttctatt ggcagaatga gtccgaacag cgcacatgga 3498541 cgccgttcgg ctgttcgtcg tttagttgaa atcaggtgcc ggatatcttg ccgtcaccac 3498601 ttttttacgt gtatagaagt cgacgctgtc ttttccgttc gcatgcagcg ttccaaagaa 3498661 tgaagatttc cagcctgaga atgggaagaa cgccattgga gccggcacac caaggttgat 3498721 gcctagcatt cccgcatcaa tgttttcacg gaagtagcgg attgcgtttg agttggatgt 3498781 gaacaagcag gcgccgttcg caaactcaga cttattggcg atttcaatcg cttctttcag 3498841 gtttttcaca cggatgacag ataagaccgg agcgaaaatt tcatctttcc agatcgtcat 3498901 ttctgttgtg acattgtcaa agatcgtcgg gccgacaaag tagccgtcgt cagacacatt 3498961 ttcacgtccg tcacatacga gtctggcacc ttcttcaaga cctttttcga tatagctgag 3499021 cgtgcgcttc ttgttgtctt cgcgaatcac cggtcctaag aacacgccgt catcaaggcc 3499081 gttaccgatt ttaatgtccg ccactttttc ctgcagcttc gccataaatt catcggcgat 3499141 tccttcttca actgtcacaa ccgcacaagc catgcagcgt tcaccggcag aaccgaaggc 3499201 agctccaacg atgtttgtaa ccgtgtcttc aagattcgca tcgttcaaga caatcgtatg 3499261 gtttttcgcg ccagtcagag attgaacgcg ttttaagttt tcgcttcctt ttttgtagac 3499321 gtattcgcct actggcttgg agcctacaaa tgaaatcgct ttaatttcgg gatgctcgag 3499381 gatgccgttc acaacgtcat gcgcaccgta tacgacgttg aacacccctt tcggaaggcc 3499441 cgctttttca aaaagctcaa ccaatttctc tgttaacagc ggagtccgct cagatggctt 3499501 taaaataaat gtgttgccga gcgcgatcgc catcgggaac atccagcaag gaaccatcat 3499561 cgggaagttg aatggcgcga ttccgccgac aactccgatt gggtaacggt agttcgccgc 3499621 ttcaacgtcc gttgcgatgg aagcaagtga gtcacccatc atcagggaag gtgctccagc 3499681 ggcgaactct acgttttcaa tcccgcgtcc cacttcacct aaagcttctt tcgtgttttt 3499741 tccgttttca atggtaatta gatgagcaag ttcttcttta tgctgagaca gcagctgctg 3499801 gaagttaaat agaattctgg cgcggcgagg aaccgccacc tttgaccatg ttttaaatgc 3499861 ttcagccgct gtttgcgctg cgtaatcaat atcctctttt gtagaaatcg gcacttggca 3499921 tagcacttct ttcgtcgccg gattgacgac atcttcatat tgatctgttt tgctttcaac 3499981 ccattcaccg ttgatgtagt tttttaattt tctgatttct gccattctta ttgcctcctt 3500041 cattagtaaa cacatacact tgtatggatg gttccggata gattcatatc aatatccact 3500101 tttcagcaag ccaagaatta aacgctttca aaaacaccaa aaaaataaat ggcggatgca 3500161 tatttacata caagcaacca tttcatgcac aacaggttac tttttggtca tttcttggtt 3500221 atattctaat cgcataatac ccataagtca atcataaaca ctacattttt tcattatttt 3500281 tattatatta atcttttaat caagtaagag aagtaagaga aggccgtcca atcttgcaaa 3500341 agatatacac cgatgttatc atttttaagc aactattgat taacttttgg tttttattat 3500401 atatttatgt tacgtaaaga ttcaagaagg agttttttat atgaaactga tgcggattca 3500461 ggaaatggag gagtacattt tatcgcatgg cactgtttcc ttagatgagc tgtgccaggt 3500521 gttcaatgtc tccaaaaaca cagtcagacg tgatatcaac aagctaacag aaaagggtgc 3500581 gattgaaaaa gtatacggcg gcgtaacatc tattgaaaaa accgcattag ttccttttga 3500641 aaatcgcacc attcagcacc aggatgaaaa aacaaaaatc gcccattatg cttcccgatt 3500701 tattgaagat cacgatttgg tcttcattga ttcaggaacg acgacaaagt ctattcttga 3500761 tacgcttgat ccagccaaaa atgtcaccat cttaaccaac agtttagaca ttatcaatgc 3500821 ggcgtcagct ttgaagaata tcaacttaat cattatcgga aacaactata agagaaaaac 3500881 ccgctccttt gtcggcatgg acgacccggc tatgcttgat aagtacaata tcaacaaagc 3500941 ctttatgtcc gctaccggaa cgacgctgac tcacggattg accaattcgg atctgctgga 3501001 gtatgaaatt aaaaagagga tttcagaaaa agcaaaagaa gtgtatctat tggctgacca 3501061 ttctaaattc ggaaaatcaa cgcttctgac gtatgcaccg tttgacaggc tgcattgcat 3501121 tgtgacctct cagccattag acgacgagta cacgcagtac tgcaatgagc atcaaatcgg 3501181 cattcatctg gcctaacgtt tacaatagtg ttgagagtct atcatccatt ttattctagg 3501241 aggcagatca tgaaaaaagc gaagctcgga aaatcagact tgcaggtatt ccctatcgga 3501301 ttaggaacaa atgctgtcgg aggacataac ctctacccga acctaaatga agaaaccgga 3501361 aaagaattgg tgcgcgaggc gatccgtaat ggcgtgacaa tgttagacac cgcttacatt 3501421 tacgggatcg gccgttccga agaattaatt ggtgaagtgc tgcgtgaatt caaccgtgaa 3501481 gatgttgtca tcgcgacaaa agccgctcac agaaaacaag gcaatgactt tgtctttgat 3501541 aattcaccag attttcttaa aaaatcagtt gatgaaagcc tgaagcgctt gaataccgat 3501601 tatattgatt tgttctacat tcacttccct gacgaacata cgcctaagga tgaagccgtt 3501661 aacgcgctga atgagatgaa gaaagccgga aaaatccgtt ccatcggtgt atccaacttc 3501721 tctttagagc aattgaaaga agcaaacaaa gacggtttgg tagatgtatt gcaaggcgaa 3501781 tacaacctgt taaaccgtga agcggaaaaa acattcttcc cgtatacgaa ggagcataat 3501841 atttcattta tcccttactt ccctctcgta tcaggtttat tggcaggaaa gtatacagaa 3501901 gatacaacgt tcccagaagg cgacctgcga aacgaacagg aacacttcaa gggtgagcgt 3501961 ttcaaagaaa atatcagaaa ggtcaacaag cttgcgccga ttgccgaaaa acacaacgtg 3502021 gatatccctc acatcgtatt ggcctggtat ttagcaagac cggaaattga tattttaatc 3502081 ccaggagcaa aacgtgccga tcagctgatt gataacatca aaacagctga cgtgacgctt 3502141 tctcaagagg atatttcatt tattgataag ctgttcgcat aagaagaaaa cagccttctc 3502201 caatggagaa ggctgttttt ttgtgcgata aattcctaaa taactgattt tgaagcaaaa 3502261 ccttacaaaa tgagccataa atccgataaa ataaaggtag tttatctcag aaagaaagtg 3502321 attgagaaag caaaagtatg aaacgttcat atcatctagc tcatatgaaa taaagctgac 3502381 ccagcttctt ttatttgctg gtcagaatag cggaccgttt cgatggtcta tggaggaaac 3502441 agaatgaaac ttaaatatgt aaaagcctta gttgcagtaa ccgttgcttt aggtgtactg 3502501 ctgccatcaa cgatttctca tgcaaagagc tttagcggcc gctcatcatc tagttacagc 3502561 agccgaagtt caagctcatc atacagcgga agctataaat caagcccgaa atcaagctac 3502621 agctcaggat caagctcttc tagcaaaaaa tccaagacgt ctgacgattc atcatcatcg 3502681 atttcgctta aaaagaagcc ttcggaaaag gcaagttcat caagctctaa aaaatcgtca 3502741 ggcacctttt ccggcgctac atcaaaagta accggaaaga catacagcgg aaaaacgtct 3502801 aaagcctatg ttggcggacg ttatgtttca gtcaatcatt actatcacgc aggtttcgcg 3502861 ccatcaggat ggtttggata ttatagcgga tttacaatgg gtatgttcat gatcagcatg 3502921 atgcacccat ggggttacac ctatcatcca gtcggaggcc ccggttatgt ttcttatggc 3502981 gcttcaccca ttgcctggat cgttgatatc atcgctttga ttattatttt aatcattgtc 3503041 atcgcattga ttcgcgcatt taaagcaccg aagacgtaca gaaggagatt ttaggcaatg 3503101 agattaatat taaatgagca agaaattgta gacggaattt gcgtgtatat ttccaatgaa 3503161 gaagatatct accctgaaga cgttgaagta aaagaactat cgtacaacaa gcgtacaggg 3503221 ttcttcgctg aagctacatt tggcctgcac cacaagcagc ttatgtcaga tgacatttca 3503281 gaaggcatta ttcagttctt agaggaatac cacaacttca atccggacgt taccgtcgtt 3503341 gaattgcaat ttgataagaa aaaaggcttc tccgccttgg tttttgtcaa cgaagcagaa 3503401 gaataaaaat gtcttaatca aaccttactc cgcgcgggta aggttttttt aatggtttct 3503461 ctgagcataa agttatttcg tttttcctaa actcagcgga tctgtgatca tctcttttgg 3503521 ctataaagtt tccgtttttt caaaacaaat gtttcaaatg agataggaaa tgggtactaa 3503581 tctattaact ttgttacata tttttagata ctcattggct caacaactga ggaggagaca 3503641 tttgtgaaga aagacacaag gaaatatatg atctactttt tcggcgcttt agggggactg 3503701 ctatatggtt acgatacagg tgttatctcc ggagcactcc tgtttatcaa taacgatatt 3503761 cctttaacga cattgacaga aggattggtt gtcagcatgc tgctccttgg cgcgattttc 3503821 ggttctgcct tgagcggcac atgctcagac cgctggggca ggagaaaggt tgtatttgtc 3503881 ctttccatca tttttattat cggtgcgctc gcttgcgcat tttctcaaac aatcggcatg 3503941 ctgattgcat ctagggtgat actcgggttg gccgtcggcg gttcaacggc acttgtgccc 3504001 gtgtatcttt ccgaaatggc accgacgaaa attcgcggga cactcggcac aatgaacaac 3504061 ttaatgattg tcaccgggat tttgctcgcc tatatcgtta actacctgtt cacaccgttt 3504121 gaagcgtggc gctggatggt cggtctggct gcagtgcctg ccgtgcttct attaatcggc 3504181 atcgccttca tgccggaatc gccaagatgg ctcgtgaagc gcggcagcga agaagaagcg 3504241 agacgcatca tgaacatcac tcatgacccc aaagacatcg aaatggaatt ggcagagatg 3504301 aagcaagggg aagcggagaa aaaagaaacg acacttggcg tgctgaaagc caagtggatt 3504361 cgccctatgc ttctgattgg cgtcggcctt gccattttcc agcaggcagt cggcattaac 3504421 acggtcatct actacgcgcc aaccattttt acgaaggccg gtcttggcac atcagcttcg 3504481 gcgctcggca caatgggaat cggcatcctc aacgtcatca tgtgtatcac tgccatgatc 3504541 ttaattgacc gtgtcggccg caaaaaactt ctgatctggg gaagtgtcgg catcacactg 3504601 agccttgctg ctttatcagg cgtgctcctg acactggggc tttccgcatc aacagcgtgg 3504661 atgacagtag tctttctcgg tgtctatatc gtcttttacc aggcgacatg gggtccggta 3504721 gtgtgggtgc tcatgcctga gctcttcccg tccaaagcac gcggagccgc gacagggttc 3504781 acgactttgg tgttatcggc ggctaacctg atcgtgtcgc ttgtcttccc gctgatgcta 3504841 agcgcgatgg gcatcgcatg ggtctttatg gttttctcag tcatttgtct tctctcattt 3504901 ttcttcgcgt tctacatggt accggaaacc aaagggaaaa gcttggagga aattgaagca 3504961 agcctgaaaa aacggtttaa aaagaagaaa agcacccaaa accaagtgct gaatgagcgt 3505021 acattataaa aaaaggaatc gtctccttat gagacgattc ctttttctgt ttacaccatg 3505081 accttgcaaa tattgttcgt aaattccaca gggtcctgaa tcggcaggcc ttcgatgagg 3505141 agcgcctgat tgtacagaag gtttgtgtac aggctcagct tctctttatc ttgttcaaac 3505201 gcgtcctgca gtgtttggaa tacctcgtga tttgggttga tttccagcac tttttccgcc 3505261 ttcacatttt ggctgtcagg catcgcattt aagatttttt ccatctcaat tgtcacttcg 3505321 ccgtcagcag caaggcagac tggatgtgat ttaagccgtt ttgagattct gacgtttttc 3505381 actttgtctg acagaatgtt tttcatttcc tcaaacagat ccttatactt gctttcctct 3505441 tcctcggact gcttttgatc ctcatccgtg tctatgccaa ggtctccgct tgatacggac 3505501 ttgaattctt tttcctgata agaagccagc attttaattg caaactcatc gatgtcctca 3505561 gtaaagtaga ggatttcata gcctttgtcc gccaccattt ccgtttgcgg cagtttctca 3505621 atgcggtcgt aagaatcacc ggtcgcgtaa taaatgaatt tctgctcctc tggcattctg 3505681 gaaacatact cgtctaagct gaccagtttt ttctcttttg aagagtagaa taagaggaga 3505741 tccttcaatt gatccttatt cgcgccaaaa tcattgtaca cgccgaattt cagctgtctg 3505801 ccgaacgact tgtagaacgt ctcgtatttc tcgcggtctt ttttcaacag gctttgcagc 3505861 tcgcttttga ttttcttgct gatgtttttc gcgatcagct tcagctggcg gtcatgctgc 3505921 agcatttctc tggaaatatt cagcgacaga tcctcagaat cgaccatgcc cttcacaaag 3505981 ctgaagtggt ccggtagcag gtctgcgcac ttattcatga tcagcacgcc attggaatac 3506041 agctccaagc ctttctcata ttccttggaa tagtagtcaa acggcatgtt ttcagggacg 3506101 aatagaatcg cgttgtagcg aaccgctcca tccacgctga tatgaacgtg tgtcagcggt 3506161 ttatcaaacc cgtaatgctt ttcagcatag aatttttcat aatcctcatc tgtcagctcg 3506221 cttttgtttt ttctccagat cggcaccatg ctgttgaccg tctgctcttc ctgcacctct 3506281 tcaaattcat tttcgctgcc ttccttcggc ttattaatgg ttgtatccat tttgatcggg 3506341 tagcgaatga agtcggagta cttcttgatg atcgctttta aacgatattc ctctaaaaac 3506401 tcgtcatagc tgtcatcttc tgtgttctct ttgattttca ggataatgtc tgtaccgaca 3506461 gaatcctttt cacacggctc aatcgtatag ccgtctgcac ccgcagactc ccatttataa 3506521 gcctcttcgc tgccaagcgc tttactgatg actgtcacga catcggcaac cataaatgcc 3506581 gcgtaaaaac cgacaccgaa ctgcccgata atgtcatgtc cgtctttcag ctcgttttcc 3506641 tttttaaacg cgagggaacc gctttttgca attgttccaa gatgctgttc aagctcatcc 3506701 tttgtcattc cgatccccgt atcagagatg gttaatgttc tcgcatcttt gtcagctgcg 3506761 acctttatgt agtaactgtc tttatcaaac gtaagcgcat cgtccgtaag cgctttgtaa 3506821 tagattttgt caatcgcatc actcgaattg gagattaact cgcgcaggaa aatttctttt 3506881 tgggtataaa tggagttaat catcatatcc agcaagcgtt tagactctgc tttaaactct 3506941 tttttcgcca ctcttgatcg ctcctttacc attatgtaaa cccttttcag catctattta 3507001 tcacataaga tgacaattgt caattagatt gatagatgca tatatatgta aatttaacat 3507061 tagttggatt tgttttcact ctttttctca ctcattctca taaaaaagag aggcttcatc 3507121 atcctctctt tttttctgtg tcattccaac ggccaaactc ccgcttcatc catatatgca 3507181 ccgggtagaa aaacaaaccg aacggtatca aaaacaaaag attatgccat gaagcattca 3507241 gaaatgcgct tgcagtcacc gggaacgtaa tctcttgcaa taaaaaagag atgacagtca 3507301 gcacaacaaa tgcagatgga atggtcacga tgcaataaaa cttgagctcc ttcttatgct 3507361 gtaccttcaa acatacaaac ctcccaacaa tttctaattc atcttaacat atgctggcct 3507421 ttcttttctc gcatgtttat cactgcacat agcgggaaga caaatagaaa aaggaggtct 3507481 cgtatcatgg gaagacttga aaacaaaaca gcagttatca caggcgccgc gacaggcatt 3507541 ggtcaagcga cggcggaggt ttttgccaat gaaggcgcgc gtgtgatcat cggagatatc 3507601 aataaagatc aaatggaaga aacagttgac gcaatcagaa aaaacggagg acaggccgaa 3507661 tcctttcacc tcgatgtgtc agatgaaaac agtgtgaaag catttgctga tcaaatcaag 3507721 gatgcatgcg gaacgattga tattctgttt aataatgccg gcgttgatca ggaaggcgga 3507781 aaggtgcacg aatatccggt tgacctgttt gaccgcatta tcgccgtcga cctgcgcggc 3507841 acattccttt gcagcaaata tttgattccg ctcatgctcg aaaatggagg ctccatcatc 3507901 aacacctcct ccatgtcagg ccgtgccgcg gaccttgacc gctccggcta caacgccgca 3507961 aaaggcggta tcaccaacct gacaaaggca atggcaatcg actacgcacg aaacggcatc 3508021 cgcgtcaatt ccatttcacc gggcacgatc gaaacaccgc tgattgacaa attagcaggc 3508081 acaaaagaac aggaaatggg cgaacaattc cgcgaagcca acaaatggat cacgccgctc 3508141 ggacgtcttg gccagcccaa agaaatggca acagtggcac tgttcctcgc atcagacgac 3508201 agctcatacg tcacaggaga agacatcacc gcagacggcg gcatcatggc gtacacatgg 3508261 cctgggaaga tgctgattga ggagaaatgg aaggaagaaa cgaaataaga gagggagccc 3508321 cctctctttt tgtcttttaa agcaatacaa ccttatattt cttcacatcc aaaaactgca 3508381 aaaactccct cgccagcact tcaggcggat gcgcctttcc ttcatccagc cgatacaaaa 3508441 gcaacccgat aatcattgcg gatacataat gggcataaag ctttttctct gcgtgaatat 3508501 cagtttgctg atgcagataa aacgattcca gcgctttgaa catatcaggt atcacatgag 3508561 gaacacccca ttcccgattg agaaaatgga caatgggcat gtttgacaaa gcagaaagca 3508621 gaatggcgag cgccttctcc gcttccttta aggaaaattc attcgggctg gaggcaatcg 3508681 tcaggtgatc aatgatctcc gcacatgatc gctgtatcat ggtttggagc aattcctcct 3508741 tattggcata gtgatcataa aaggttgcac ggcggatatt gcttttacgc gtaatatctg 3508801 aaatcgtgat gcccgcgtag tcttgtttct ccgccaatac atccagaaat gccttctgca 3508861 gcgcctctct cgttcgaacc acccgcctgt cgatttgctt ctccttctct cgctctcctg 3508921 gcacagcttt tccaaacagc caataaaacc gcttttgaga aacaagctcc cataccttct 3508981 ggctgatggc ttcaggagac gcggccgcat cctcattcag ccaatacagg ataatcgcgt 3509041 acgtgtacaa ggcccgataa tgtccataaa tgtcccgttc aatcggcgtt aaattcacat 3509101 ggatcggagc cagcagcaca tcctgctgaa acacatcctt aaaaaaacga tgaaaatgtc 3509161 ctctgttcat catcacagaa aaaaaggaac gatgctcatg aacaaaggac agcgtcggat 3509221 gcaccgtttg ccgttttttg ttcaaatgaa gggtatccat atgactgaag gcgtcaaaaa 3509281 gcgctttgcc cagtccttcc ttcatgtctt cgatcacatc ctcaatgatt gaaaacttat 3509341 cctcataata aaggtagagc gatccgcggc tcactttggc cttctcagcg atttctttca 3509401 ttgtgatgtg ttgaatatct ctatctttca ataaagccag cagcgcctct ttcacttgag 3509461 cttcggcaga ttccggcaca aaagacacct ccaatcatta gacagatctt agatatatgt 3509521 acggtaacgt atagatggtt caccgttgtc tttcttacag aaaaggtacc accttataat 3509581 aggtccgaga aaagaagaaa gcaaatgagg gggattttac aatggaacag caagtaaagg 3509641 acgacatcca gcgtgtcttt cagcttcaga aaaaacagca aaaagccttg cgcgcttcaa 3509701 cagcggaaca gcggagagaa aagcttcaac gctttttaga ttccgtcatc gcccatgaag 3509761 aagaaatcat cgaagcgatc cgcaaagacg tccgcaaacc atatcacgaa gtcaaaaaag 3509821 cggaaatcga aggaacaaaa aaagcgatta gagataatat gaataacctg gaacaatgga 3509881 tggcgcctaa agaagtcggt tcatcgttaa gccctgacgc aaacggaatt cttatgtacg 3509941 agcctaaagg cgtcacactc atcctcggcc cgtggaacta tccgtttatg ctgacgatgg 3510001 cgccgcttgc cgcttctctc gcagccggaa acagcgcgat tgtgaagctg tccgatttca 3510061 cgatgaacac gagcaacatt gctgctaaag taataagaga cgcttttgat gaaaaagaag 3510121 tcgcgatttt tgaaggagag gttgaggtgg caaccgaact acttgatcag ccgttcgacc 3510181 atattttctt cactggaagc acaaatgtcg ggaaaattgt catgacagcg gctgccaaac 3510241 acttggcatc tgtcacactt gagcttggcg gcaagagccc gacgatcatt gacagtgaat 3510301 acgatctgat ggacgcagcg aaaaagatcg ccgtcgggaa attcgtaaac gccggccaaa 3510361 cctgcatcgc acctgattac ctgttcatta aaaaagacgt tcaggacagg ttcgcgggga 3510421 ttttacaaac agtcgtcaac gctggattta tggaggatga tcatacccca gaccgcagca 3510481 aatttacgca gatcgtcaat gaccgcaact tcaaccgcgt caaagatctg ttcgacgatg 3510541 ccatcgaaag aggggcggaa gtggtgttcg gcggcgtatt cgatgccagc gaccgcacga 3510601 tctcgccaac cgttttgaaa aacgtcacgc ctgacatgaa aatcatgcag gaggaaatct 3510661 tcgcatcgat cctgccaatg atgaactatg aagacatcga cgaggtcatc gattacgtaa 3510721 atgaccgcga taaaccgctt gcactttatg tgttcagcaa aaaccaagat ctgattgaca 3510781 acgtccttca gcacacgaca tcaggaaatg ccgccatcaa tgatgtcgtc gtccatttca 3510841 gtgacgtcaa cctgccattc ggcggcgtca acacaagcgg aatcggctcc tatcatgggg 3510901 tatacggatt caaagagttt tctcatgaga agggtgtatt tattcaggcc gctgaataat 3510961 cgcatgatca aaaggcgctt ccttagagga gcgcctttta ttgtaactcc ttgaccaaaa 3511021 gcaattcatc acggataggt attttattat ctgccagtaa aggaatttcg ggcttcatct 3511081 ttctggccgt ctcgactgca ttcacaaata gtcgatccaa ccggtaccct ctcttctgat 3511141 aaaacgctaa tgcatgaata ttatcattgg ttgtgatcag ttttatttgt ttgatatttc 3511201 tctctctgca tgcttcctcg gctttctcta gcagagctgt tccgatccct ttattctcaa 3511261 tgacactatc cagcgaaatg atttcacagg catcttcttc aaatatgtat gtaataaggc 3511321 caacaatctg gttatcatcg ttgagcattc cataaccatc taattcatcg cagttataaa 3511381 taccgctaga aataaccatt tgcggactgc cccagtgttt ttgaaaaaac gcggaaacaa 3511441 gatctttagg tacctggcat gtcggaataa tattcatatt ttcctccttt tagctgaaca 3511501 aaaataagag aattaacaac ctattttatg tcattaatcc ccttatctag tatttactag 3511561 aacttataac ttgtcaaaag ctgtctgaat accaattgcg tggattgata aggatcaaaa 3511621 tctgaatcct gagattggaa gatttgctct ggggtcaatg tctctgcgtt ctctgataac 3511681 gtttgaatca gactttccaa atatccattt aactctgatt tggacgattc atgtagggat 3511741 tgatgattta cagcgagttc tctaaatctg ttatcactga ttaatttttt tcgaagagct 3511801 gctagcatca agtcaagcca tgcaggctgg ccaaatgtaa tatttaaagc taacgttgct 3511861 tgatcagatt tggtggagtg ccataaacct cttggcaaat acagcatggt tcccggtgtt 3511921 aaattaacga tttctgcatc tggcagatcc tcttttggcg gatctccttt ccaatatgac 3511981 tgtaaatcat caggatagta aggagcctct gataaatcat agtgctgcat tggattgctc 3512041 acattttcat tcttggcaag cttccatgtt ttctcacctt gaatttgaaa aatcaagttg 3512101 gtgtaggcgt caaaatgggc tttgaatccc ccgccatttt tcgccgcgta aacaatggct 3512161 ttggaagaag tacccgcagg cagtcttaat tccgctttga gtttttctat ccaccttctg 3512221 acttggggaa taaataggtc ggtgaaatca aactctaatg cagccccttt ttcataccac 3512281 tctaaagcct ctgcaggtga cacaagaaat ctgtctgtga tcccttcaga ttcttcaatc 3512341 acagcatcac caacgaccat gactggatta ttgtagatag ccaatacgtt ttctagcgtt 3512401 ctaacctttt caaaccccgg tatgcttgta aatctctcca cttctcctct ggctaccaaa 3512461 ggttttacag gccaatattc ttctaaaaac tcactcatcg ttacaggact gatgatagac 3512521 tccaaaaccg attcggttac agcactcata ttatccctcc caaaaaaagt aacttcacca 3512581 caaagatata acattttttt ctaaaagtaa atattgacag aattatcaga ggattataat 3512641 atttagttgt gcgtgatagc ctattttttt acaaggaagg agggaaaagg atgaaaaagg 3512701 cttataagaa acctcgtctt tttgaactgc gccgtgctgt agcagctggc ggccattaat 3512761 ctcatatagc atttgacatc tagtactcta ttttaggagg gatgctcaat gaaaaaagct 3512821 tataagaaac ctcgcctttt tgaactgcgc cgtgctgtag cagctggcgg ccattaatct 3512881 catatagcat ttgacatcta gtactctatt ttaggaggga tgctcaatga aaaaagctta 3512941 taagaaacct cgcctttttg aattgcgccg cgctgtagca gctggcggtc attaatctta 3513001 tccaaaacga ttaacgtttg aggctatcac gccaacttga taaggaggat gctgaagatg 3513061 attacggctg aagaatgcag aacgtacaaa gaatttgttg atctttacca atcctatctt 3513121 taccccttgc ttggcgccag actgtcccgg atgtattccc ccaaaaacaa agtcattatc 3513181 gatatgggca caggtccagg ttatttaagc attcagttgg ctaaaagaac aaatgcgcac 3513241 gtgcatgctg tcgatattaa cccggccatg catgaaatcg ctcaagaaga agctaaaaaa 3513301 agcggagtaa gcagcctgat ttcatttgat ttggaagatg tccaccattt atcttacgct 3513361 gaccaatatg ctgacttcat cgtctcctac tcttgcctgc atcattggga agacgttgtt 3513421 aaaggactta aagagtgcta tagagttctg gctccgggcg gaaaaattgt cattttggat 3513481 acatttaatc cccaaggaag ccatttagag attatgcgaa aacaaatcaa agaaccggaa 3513541 tacttcaggt ttgtaagaga ggcatttgaa gaaagttatt cctttgaaga cattcaccag 3513601 tttgttcagg atgccggcat tcccaattat tcattagaaa cctttcactt tttaccggag 3513661 gattttatag aaagcttaga tgagctggag gatgctcccc tgtgggaaca aaatgatcaa 3513721 agtactgatc atgaaattga gtctgtcaca tggatgttaa cgatagaaaa agaaaaggaa 3513781 ggtgcattgt aatgatcaat gaatcaactg ttttatccaa aaatccagaa atgccatcaa 3513841 gaaaatattt gaaaagcatt attatagagc cgggcatcac tttaaatgaa atggcatcag 3513901 atatttataa ccatatcgac ggcaaggtca gcatacatga tatttgctca aaaatcgtca 3513961 atgaatatga tgttgattat caaacctgct tagaagattg tatggagctg tttgagttgc 3514021 ttattgatca tgaagcaatc aaagttaagc agggggcatg agaattggaa aaacaaaaag 3514081 tgcttgcttt accagacgat gtacatgagc tgagtacaca ccgttctaaa tcaatcgtaa 3514141 attacatcat cactctgctt gcctttgcca aaaaacaagg attgactcat caagatattg 3514201 taagctggat tcacgagcaa tatgaggaaa gaggatatta tgatgagtgg agacacatta 3514261 acagccaaca accagttgga tcatttgtgg aactctttat aaaaggaaga cgtttacttt 3514321 atgacaaaat tgaattgttt gaaacagaag ataaatatgt cgtaaatacc cacacttggt 3514381 atgaaaaaga acctagtgag gccttttttt attttgaaat tgatcccgaa gaattttctg 3514441 cgtacgcttc cattctcgca atcgaaaacg caaaacgtct cggaattaaa atcgatattg 3514501 taaaagaaac agatgtagag acagcttata tctataaaca tcaataacgc tattgggagg 3514561 gagacatatg tgcgggctcg cgggtattat aaatctggct gctccccgtt ctcaggaatg 3514621 tacctttcat atattgaaag gcatggcaga tgccatcagc tataggggac cggatgatga 3514681 acaatatcat attgattcca aagtcggctt tgcatttcgg cgattgtcca ttcttgacct 3514741 tgtaaatgga cagcagccct ttttaaatga ggatggatca atcgtcgtta tggtaaatgg 3514801 agaaatttat aactataaag aactgaaggc ttctttacac aatcatatgt ttaaaacgac 3514861 atctgattgt gaagtaattg ttcatttata tgaagaaaaa gggattggat ttgtagacga 3514921 catcatcgga atgttttcaa tagccatttg ggacaaaaat aaaaacaaag tatttttagt 3514981 tcgtgaccgc tttgggatta aaccgctttt ttacacagag ctaaaacacg agcttatatt 3515041 tgcctctgaa ataaaatccc tattttctca tcctcactgt ccccgccaat ttaattggaa 3515101 agaagcactc tcagacattt ggctaagcgg ggaagcagcc agtaatcata aagaaaccac 3515161 ttcctttttt gtaaacatcc aaaatctcga tgctggccat tatctcgaaa ttaatttgac 3515221 aacaaatgaa cgaaaaacag caagctattg gtctttacag gatattttgc tcaggcaagg 3515281 ctatcgtgag aatctccatc ccgatgacct gattgaagga tatagagaac tgctggcaga 3515341 ttcagtccat agatgtttac aaagcgacgt tgaagtcggg ttgtttctta gcggtggcat 3515401 tgattcagct gcagtcgcac attttgctgc agaaaaacag gatctccata cgtttacagt 3515461 attaagccaa agtacattta caaatgaaga tgcaaaatat gcccattggc tggctaaaga 3515521 tttacacctt ccaaatcatc aggttctcta tcaattaggg aacgatgagt tattacaacc 3515581 agagtcatat aaacatttgt tatggatctg tgaaacaccg ttttgcggac cggaacaatt 3515641 atataagttt catttacata agtatgccaa agcgataagg ccaaacctga aagtcatgct 3515701 gaccggccag ggcagcgacg aatttaacgg cggttacagc acgacacttt caccagccga 3515761 gaacccaagt tgggaaggat ttattgaatc ggtcaatacg atggagatga accggctgca 3515821 tcggctgcag ggaaatatct ttagagtgtg ggaggagcat tttggacttt ctcctataaa 3515881 cctttcttat ttaaagagca atgattccag ccaagcagat ccttggcaat cgtatgtcct 3515941 gacaaaatac cgtgatctgc aaatgtataa ttgctggcat gaagatcgga tcgccgcggc 3516001 taatcatatc gaaaaccgtg taccgttctt ggaccatcgg cttgttgaat gggtttgcgg 3516061 aatacctgat ggactccgta aagacttgtt atgggataag tcggtattgc gaaaatcatt 3516121 aacaaatgag ctgcatacaa gctataccca ccggccaaag gttccttttt tctatggtaa 3516181 ggacgtgaga tatacacata aaatgatgtt tcatcttctg aagaaaaaca attatcagct 3516241 tatagaggag gccttctctc acagcgatgc ctccagcata atacaggttg aacacattca 3516301 tgccatcatg acatatttgg aggatgatcc tgagtttaca aattttgaat ttttattaag 3516361 actggtgaac atgggacttt tatcaaaaat gactaaagaa accccttctg ttcaattaga 3516421 cataaccagc catttagaat cgataacaat aaaagactgg cactcacagg aaggtgatat 3516481 tgccagtcgt ttaaatatct cagccaataa gtgtgaagga caagatattt tggcgctaaa 3516541 ccctggcgtc actctgttaa ggccggaaag cgatagtgag cattgcatct acattgcgga 3516601 agaaggattt attcagttta ttgtttcgga ggaagacgtc ggagcttggc tgcatattct 3516661 ctgcgatatt aatggaaaag acacacttca tacgatttta gacagacatg gtgtcagcct 3516721 tgaagaagtg gccaaatata ttcaagaagc catcgaacac aatatcattt tgatcaaaca 3516781 aaaaaatctg ccagaaggag catatagatg agcatctttt attcgttttc cgcacttagg 3516841 ggattagcaa tggggatttt ttcgcctatt tggattcttt atctgatatc taaagattat 3516901 gatttccttc agattggatt aatgggagcg gtacttgaaa ttgctaagct tatatttgaa 3516961 gttccttccg gcgtttttgc tgatcgttat ggaattaaaa tttcaattgc cagttcattc 3517021 tttttctcca tccttacatg ggccttcttc ccttttatcg attcagctgc tatttgcata 3517081 ctggctatga tcatatgggc tttatcagat tccttaattt ccggttcttt tgaaacttgg 3517141 atgagccgtg tcgcagggga agatcgattc ggcaaagaaa tgatgaaaaa cacacaattg 3517201 ctaatcactt ttttaattat tggaagtatt gccagcgggt atttgtattc attaaatatc 3517261 tattttcctt tcctgctcgt tatggtgatc tacttattac tatttatttg gatgtctgta 3517321 tttattaaag tcccttctgt ttccgaaaca aatcatgggg atcagaacca acatgattcg 3517381 ataaagatta tcaaagaaag tttaaaaatt atctttaaca aaaaaagggt tcttttaatc 3517441 gtcatagccg gtttctttac agccacagcc tatgacacaa tttcccgtta ctggcagcct 3517501 tttttgagtg atttaggctt ttcagaaaag tcactgggat atatttttgc cctaggaggg 3517561 tttaccgctc tcgttctttt gacattaacc atcaggttcg aaaagaagat cgaaaaaaat 3517621 ccatatctcg ctttaacctc attggattcc atgggcatgg tcatgacttt tctattgtct 3517681 agagcattca ggccgctggg cattccatgt acagcgtttt tgcttgcaat tgaagatatt 3517741 catcatccga tcgtaacaag ttacttaaat aagtttttcc ccgattcata caagaacaca 3517801 cttttctcgt taaactcagg ggtaggagca attggagaaa ttctttccgg tgtcattttc 3517861 ggcatcattt ccgcagcctt tgggctctct gccatgtttg ttgttgtagc tgtatttcta 3517921 ttaatcccta ttatccttta tacgatagtg cctaagatta aagacaatga tatgaaagtt 3517981 cagattgaaa aatcccagca agtgtaaatg ttttgtatca cagtaagaag accttcttat 3518041 taaaagaagg tcttctgcta ttctattcag ttatttccca aaagccatca gcttcgtata 3518101 acttccaata taaagtgttc cgtcctcagc gagctgagga gaagacacga cgttgctgtc 3518161 ggtttgatag ctccataatt cattgccgtt tgcgtctgcc gcataaacct tcatatcatc 3518221 tgacccgaaa taaaccgttc ccttcgcgtc aatcagcggc gccgttctga cagggccgtc 3518281 tgtgtagaat gaccagttca tatccccgtt tttgctgatg gaaaacagct cgccgcttcc 3518341 tgagccgatg tagatattgc cattatgatc aatcgcagga gatgagctgg agaacccgtt 3518401 tagcgggaat gtccatttca aactgcctgt tgatgtataa gcatacagct gtccatcttg 3518461 gttgccggca taaatgtttc cgtccttatc aatcaccgga tatcctttaa acgcatttga 3518521 cgtcgttctg gaccatttca cctgtccggt tccggagttg atcgcataaa acacgtaatt 3518581 atatgtgccg acatacacgg tgccgttttt ggcaagcacc ggcacagagc tgacgacccc 3518641 atttgttttc aacttccagc gctctgtcca ggttgatttt gacgtcggtt tgatcgcgtg 3518701 aacataatta tcaagtgttg agaaatacaa cgtcccgtct gaaccgatca ccgtttcaga 3518761 gcttggcccg ccgcttaacg gaaccgttgt taaaatttct cccgtttctt tgtcaataaa 3518821 ataaatcttt ttgtcatagg atgccaaata gataacgccg ttggtcccaa gtacaggaga 3518881 ttgcgtatat gtttttccaa gattgcccgt cacccatttg actgagccgt ctggattaaa 3518941 ggctttcatt tccccgtctc tggaatgaag atatactgtg ccgtctccgt caatcacagc 3519001 ccccgctcca ttttgcggag tcgttctgat gtcgttttgc catttcagcg tcccgtctgt 3519061 atttccggcg aaccggcttt cgcgtgacca gttaaacatg gcaggcgcca tcgcttgtac 3519121 atcatatctt cctggcaaaa agccagatgc tccattattt tgagaaaaca ccgtttccgc 3519181 cgcataagca gctgtcggct gaagcacttt ggcagcgggc acatcagaaa cagcgccggc 3519241 cgaaacagcc gccgccaccg cagctcccgc aatcaaagct ttcatacgaa atgacttgac 3519301 catcattgag acccccatta tatgtaactt ctaatttgtg accatcataa catattcatc 3519361 cattttataa atctatttca caaaaacatc acaaactaga aaactatgta agagtattca 3519421 cggacgtttt ttcagcaccc gatcgaaatg cagccacaaa ccaaatgacg ttgacagcag 3519481 ccgcagcgag actaactccc aaaacaaaga tcacctcaga aagcagatgg tcactaaaga 3519541 aactaaacat caagataaaa ccggccgaag acaaatgaat caaaagcccg aagccgcaaa 3519601 gcaccgccat gacatacctc attgcatcga ctccgagcat ataaacgaga aatggaatga 3519661 aatacaagac aaggatcata ccgacagctg accacatgcc agctgaatta aactgattgg 3519721 ccgccgctcc cgttccggcc agcggcgaaa gtgaagccgc cacaatcacg gcgcaaaaaa 3519781 gaaacgcaga aatggttgtc atgatcgcca cgctattttt ttttgacatc aaactcctcc 3519841 tttaatagaa atattaacct tttttattat aagtaagttg aatgttatat tcattatatt 3519901 tttaaaaaat tccagaatac atacacaaat gctatgcttc tttctagtat atttatatag 3519961 taaaaaacaa aggataaaag actcattttt ctgtaatatc aggattttat caccatacca 3520021 tattgcatgt acatgttttt caaagtatac tattccagat taattcagag gagagagaaa 3520081 aatacatgga aaaaccagca ggattttgga ttcgtttttt agcttatttt attgacggca 3520141 ttattgtatc tgttcctagt tatattattc tatttattat caattctgtg tttgtagctg 3520201 gggctgtggc aacaaaccct tacatgacgg aagaagagta tttagtgaaa tacatgacgc 3520261 ttgcattttt gcctactatg ctgatcatga tcgtcatcag cgtgttatat tacgggctgc 3520321 tcacagcttc taaaatgcaa ggcacacttg gcaaaaaaat tcttggcctg aaagtggtca 3520381 atgaacaagg tgaacgggtt tctgtcggac agggaattgg ccgttacttt gcctatatct 3520441 tatctggaat catcttttat atcgggttta tcatgatcgc ctttggagag aaaaaaggcc 3520501 tgcatgacat catttgcaaa acacgtgtcg tgtataaata atagaaaaaa gtctagacgc 3520561 caataggcat ctagactttt gttttctttg caataggctg ccacgacaga tacgtagcgc 3520621 ttctccacaa ccactcaaac ggccccatcc gaaagacacg aagccaaagg tggctgaaga 3520681 ccatttgaac ggcacaaaca gcaattgtaa tgagcacacc ggcagcaggg tacacttttc 3520741 catacaggcc caagccgtaa tgataaaaaa tccaagtaca cacaatagac tgcatcaaat 3520801 aattggtaaa tgccatcctc ccaacagcgg agaatgattg cagcactgtt ctcactcttg 3520861 ttttatgata aagatagaca accgttgtaa catagaaaaa catgaggaaa ggcgcgccaa 3520921 tcagcaaaca tatttcttta tccgttacac tgtacagcac ctgggcgccg atgccgatga 3520981 caagcccagc catccataat cgttttaatc ctttgcgatg cttttccggt tcatgcaaat 3521041 accgtgattt tgctgccgca gctcccagca aaaacatgct gaaatatgga atggatgcaa 3521101 agaagtagtt gagcggatta tacgtaagca tgccattcga agacatgtaa acaagacggt 3521161 cgtggatccg ctgttctgca atatccttca ggctgccgct tccataaaca tgaatcgctt 3521221 gttttgcctg ctgtgttacc gcttgtaccc attcctgtcc gtttgattga tcaaaacttg 3521281 tcaacatgaa cggaatggaa aacagaagat acaaagagac cgcccatatc agcagtgttt 3521341 tcggctttgc ttttcgaaac aagagcagga caaatccgag cagggcatat tctgttaaaa 3521401 tatccccgtc ccatatcaaa aaggcatgaa tcgttccaaa caagagaagc gccattaacc 3521461 ttctcacata taacggaaca aaccgtttcc ctttgttttc tgctctctcc atcatgacaa 3521521 ccatgccaaa tccaaataaa aaggaaaaca ataaaataca ttttgtttga atgaagaatt 3521581 tcagtatgtc tgcggcggca aaatcagctt cagaccactt atccatgaaa aaattctctt 3521641 ttccaagcat agacaaatac atatccggat aactgaaatg tgccagattg acaaataaga 3521701 tgccgaaaat cgccattcct ctcagcacat caagcacacc gatccgctca tttgttaaag 3521761 tcggctgtaa tgaagacata gccatcacgc tccttttttc tgtaccttaa gggtaggaaa 3521821 aaatgaagcg cggtaacatc gatttaggtg tcaggccggc atgaaaacct tacaatcttg 3521881 tcatctttat ggtttcatca cctttaaatc taatgcttcg atattctgca aaatgcgatc 3521941 aaagcgcaaa gcctgaggct cacatgggaa gatgtggcct tcatacgggt cgcctaacgt 3522001 ccggaaaaac ggttcaaata aaccaggaac caatacgccc accatctttg tatagtgaga 3522061 atcaaggcga taggagtgaa cggtatttgc agggacatgc aggaaatctc ccggattcag 3522121 ctgaatttcc tggccatctg tccacatcgt catctggcct tcaaggcaat aaaatgtttc 3522181 tgtatgatat tcatggtagt gatcaacgat tcggtcacct ttagggcctt cagatgatac 3522241 gacgataaac tggccatctg tatttttttg tgcagccaca atgcggtgaa gctgatctcc 3522301 agtcaacaga cgatctcctt ctccagattc aagaacgtat ggaaccgctc catctggcag 3522361 ctctgtaagt tccgctaatt tggccgaaca tgcaggcttt gcttcatcta gaaatacaat 3522421 gtccgctaca gcggctgctt ctgcaaatcg ctcgtttgag acttcttcgc ttgcgtacgg 3522481 cggatgttca gcgtgatcat acggattccc aataacggaa tacaagtgcg ctacgtttcc 3522541 tttcatcgtg taagacacca gtcttgttct gtggctctgc atccggtagc tgtgcggtgt 3522601 tcccgccgga atgttggcat aatcacctga tattaataaa tagcgttcac catcaagtgt 3522661 cagttccagt ttcccgtcca aaacgagaat tccttcatgt gtgtccttgt ggacgtgaag 3522721 cggaaaggca tctccttttc ccccggaaag aagcacgatc tcaaacaaat cacctgtgct 3522781 cctcccattc gccatcaccg tggcaacctg tctgccgaac agatagcgct cgccttctcc 3522841 gctccggagc aaataaggca ttttttcttt aggcaatgaa tgtgtacata atgttttcat 3522901 attatcgctt cctccaattt agaccagtct atatattatc attcatttgt ctagaccgtt 3522961 ctatataatt gtaggagaaa ggataacaaa atgctaccct ttttttctca ccagcactgg 3523021 tatttgttcg gcaatgagaa gaagaggcgt tttgtcttta ttcgttaacg aaagcatgat 3523081 gccgccctca atcatcgaat taatcagcgt tccaagctga tttgcttctt cttctgcaaa 3523141 tccgttttcc attaattttc tggcaaaaac cgcttcccag cttttaaaca ccttcatgca 3523201 aaccgtccgc agcggttcac tgattaacgc tgtctcactc gccagcaaac cgactggaat 3523261 acctttaatg ctttctgtgt tgtcaaattg gctggctgtt tttttgataa aaagctgaat 3523321 cgcttcaaca ggatcagagg attcatccat gctttgctgt atcagatgtt caacgatctt 3523381 acctgtatat gtaaccgctt caattgctag ttcttctttg ccattcggaa aaaagtgata 3523441 aagcgatcct tttggagcac cgctttcttt tacaatctgg ttcaaacctg tcgcgtgata 3523501 tccttgcagc tggaacagac gtgacgccgt gtgaaggatt ttttcacgtg aatctcctct 3523561 gctagtcatt aaaacattcc ctcctaggta tggtagagcg acttatataa tataaaaaag 3523621 aaccctgtga ttgtcaaaag gggtaagacc cttccggatg gggtaatgta caaaaacagc 3523681 gtctaggagg gatctctcaa tgacaatcga tcattcagtc acaaatacag agcagcttga 3523741 acaacagaac cccgccataa aaacaaagct caaactgaaa aagcttaagg atcaggtgat 3523801 cgtcattacc ggcgcttcaa gcggtatcgg acttgtcacg gcgagaatgg cagctgaaaa 3523861 aggcgcaaag gtcgtggcag cagcgcgaaa tgaagaggcg ctgaaggagc tcactgatga 3523921 acttaaggaa aaagggcacg acgccatatg ggtaaaggcg gatgtcggaa aagaagagga 3523981 cgtcaaccgc atcgcagaaa ccgcgatcag cacattcggc cgctttgata catgggtcaa 3524041 caatgcggcc gtctcgactt tcggacacgc catggacgtc accgtcgaag acatgaagcg 3524101 catgttcgac acaaatttct ggggacctgt ttacggaaca agagcggctg tcaaacacta 3524161 caccggcaga ggtgtgccgg gcgcactcat taatgtagga agcctgttcg gagacagggg 3524221 aacggtcatt caatccacat atgcatctgc caaatttgcg cttcacggct ggacggaaag 3524281 catccgaatg gagcttgaaa aggaacaggc gcccgtctcg gtaacgctca tccacccggg 3524341 cagaattgac acaccatata acgagcatgc gcacagctac ctcgacaaac agccggctca 3524401 ttaccgctcc atgatctatc cgccggaagc ggtcgccgaa gcgatcctgt ttgccgccga 3524461 acaccctaag cgcgacatgt acatcggctc acaggccaaa gccatcgcca tgctgggcgc 3524521 gctttttcct cgtctgaccg acagactgat ggaaaaaatc atgtatcaca gccagcatgc 3524581 cgaaagaccg tccaatccga gagaagaaag cgctctttat gatgctggct gcggtatgca 3524641 tgacagaggc acaaataaag gatggatgag gtcaagaagc tactacacaa aagcgacgaa 3524701 gcgcccaatt gtatcggcgg ctgttgttgc cggactagtg gcttgggctg ccgccaaacg 3524761 atgcagataa tctctgacca taagaaaaac ccatgctgtt ccagcgaacc atgggttttt 3524821 cagctgttaa tcgataaaag ccttgttcat acgctgcagc agctcgccga acatctcttt 3524881 ttcctgtgtt gaccattctt tcagcatctg ttcataacgt tcaaggcgct tttgctgatc 3524941 ggcttttaat agttgtttgc cgagttttgt aatggtaaac aggctgactc tcccatcaga 3525001 cgggtctgag aaacgataga tgagctcctt tgcctctaat gcagctgctt gtcttgaaag 3525061 agtagaaata tcaagcttaa acgattcagc caattcctta acacgagcag gcccaaactc 3525121 atccaattgt ctcagtaata agtacgaaga tctctccaaa ttccctgttc ttttctccga 3525181 ttgatccaga taaacagctc tcctgataaa agtcgtcagc tcatattcaa ttaattcaac 3525241 tggattttga ttttgcaatc gctctcgctc cctattccaa tctccggcat tgacaacatc 3525301 atatatactt gtataataca aatgtacatt aactgaataa atacaagtcg ttatatgact 3525361 aaatcaatta ttatacttgt atagtacaat catataaaaa gaaagtaaag cgattcctca 3525421 gaaccatcct agaagcaagc accagaaagg aggaagctgt tctgattgga gagcagcact 3525481 tgatgtgaaa gtcatacgaa ttattttgca agtgttgata ttatatgtat tttttatgat 3525541 cggggaagcc attcagcatc tgtttcattt acccgtgtca ggaagcatcg ttggattggt 3525601 attgcttctg atctgcttgg gcctccgtat tgttcccgtc tccatcattg aagacggagc 3525661 agggttttta ttatccttcc ttccattgtt gttcatcccg gcaatgacag gagtgataaa 3525721 ctatccgtct ctcatttcat tcaatggcct gatgctgctg attacagtcg ttctcagcac 3525781 catcgtcacg atcattgcgg ctggattcgc cagccagcta ttagagaaaa aagcaaaaaa 3525841 acgggaggag aaagagaaat gcagcaagca tgtatcgcga tcattataat tcttttaaca 3525901 gttgccgctt atttagcgat ggtcaaactc tataagcgat tcccgcttcc atttctgatc 3525961 cctgttctga caacgacaat tttgattgta gcggctttga tgatgtttca tgtttcctat 3526021 gaaggctata tgatcggggg gaaatggatc aattctttgc ttgggccggc tgttgtggcg 3526081 ctggcctatc cgctttataa gcaatggcat atcattgtca aacattgtgt tcccatttta 3526141 ggcggcgtcc tggtcggctt atgcatggga atgatcagcg ggctgatctt cgcagaagca 3526201 ttcgggattg atcatgatct cttattatcc attctgccaa aatcgatcac aacccctgtc 3526261 gctattcaga tcgccgccgg tcttggcggc gtcccttcca tgacagtcgt atttgtcatg 3526321 attgcgggct tttcaggcgt catcctcggg ccgcttttcc taaaatggct tcgcatacgc 3526381 agctccctag gacaaggcat tgcattaggc agcgcctccc atgcactggg tacctccaaa 3526441 gcgttggaat atggggaatt ggccgtatcc atgagttccg tctccatgac gctttgtgcg 3526501 gtgctcggct cattcttcgg cccgctcgtc gtctggctgt ttcatattta acaaagaaag 3526561 actgccccgg gggagggcag tctttttcgt ttaagaagca aaaaaatcaa tcaacggctg 3526621 aaagtcctta gataaatcaa cgtcattcgg ttctgcttga agcaggcggt caatcatacg 3526681 ctccagctcc tcaacatcat tcttatccgt atattcaatg aagtttaagc tttcaagcca 3526741 atcccgatat gaatgtttgg ctttgccata gctgtttcca aagacaaggc aaggtgtttt 3526801 ggtgataatc gagaaaatca tcgcgtgaag gcggtcggta atcaccaatt tactggagcc 3526861 gatgcggtcc agcatctcca taaaatgctt ttcacgatca gcgtaatcga tggtgtctac 3526921 cgtatccagc accgtatcgg tacgctctgt gtaagttgtt ttttctgccc attgcttcat 3526981 ctgtgaaata aaatcttcgt cagtcacttt ctccttatcc gctcttaaaa taaagagaac 3527041 gccgtcccgc tcgagctctc gcggcacaat atccaaggaa agcaccatgt ccggtgtaaa 3527101 gatcacattg gagttgaagg tctctttcac aacatccagt gtttgcgtct cacgcgcagc 3527161 aatcgttaag tttgtatttt gatggtacgc atcctgtgtt tttttctttt ccttctgtcc 3527221 ttcctctgta tcctcaaaat aaacggattg tggcagagaa attgatttgt agtctttaaa 3527281 cgccgaaaag acctttcttc tgtcttcctc aatatcgaga taaaggtttc ctaaattccc 3527341 tccgcctgta aagcagacaa tatcgtcttc acgaatgatc tccttcacca gttcaatgcc 3527401 ctcatccgtc gcataatcca taatctcaat gtattcataa tacggaaaat gatttttgat 3527461 aaatttctct tccgcatacg caatcgcttg gtcgccaatg tttgtgtagc taggggaacc 3527521 aaacaaaaat acttttcgtt tatcatttaa cagagcttcc ggctccacat ttggcgcaat 3527581 gccttttact agttttttgc ctttgatttc ttgtacagtc atatctgcgt cctccttctg 3527641 ggatgaattc ctcattgtgt gttaactgtc tctacccaaa aagaaggatg gctatgcatt 3527701 ggcatgtgca tcggctatat cagaaacatc gttttcgcca atttgataga cgctgcaatg 3527761 tcccgcgccg ttctttccat atattccgcg gcatgttcaa acgcgtcttc tagtggcacg 3527821 gctccgggga cgatgctgaa aagcgcatcg attccgtgtt gatagacggc attactgtct 3527881 cgggaaattg atcccgcaat gccgataacg ggcacatcgt atgatttagc ggccttggcc 3527941 accccgatcg gtgtttttcc atgaaccgtt tggctgtcga ttcgtccctc gccggtaatc 3528001 acaaggtctg catcctgaac gatactttca aaatcaaccg cttcaaggac aatatcaatg 3528061 cctcttttca ggtcagcctg aagataagtt agcaggctcc atccaagacc gcccgctgca 3528121 ccggcgccct ctgtatctcg gaaggttgat ccgagcgctt tttctgccat atcagcgaaa 3528181 tggcttacgt tctggtctag tacatccaac atgtcggccg tcgcgccttt ttgcggcccg 3528241 aaaacagccg tagcaccctt tggtcctgtt aacggattgt ccacgtcaca ggcaacttcc 3528301 agtttgacat tccgcaatct ggaatcaagc ccgctcacat ctattgatgc aagctgagat 3528361 aacgcgccgc cccctgggcc aatctcgctg cctgagttat caagaagcct tccgcccaat 3528421 gcctgaatca tcccggctcc cccgtcgttc gtggcgcttc cgccgattcc gatgatcaat 3528481 cgctccgctc ccgcatcaag agctgctccg attaattctc ccgttcccct tgttgtagtg 3528541 atgagcggat ttcgcttatc tacaggcacc agatgcagcc ctgaagcagc agccatttca 3528601 atcacagctg ttctcccatc tcccatcatg ccaaagaaag ctctcaccgg ttcccccagc 3528661 ggccctgtga caacttgctc tatgatcctt ccattggtcg catcgaccag agattgaacg 3528721 gttccctcgc cgccatccgc caccggcaat tttctgtaat cagcacccgg aaagaccgat 3528781 ttgaaacctc tttctatcgc ttcggctgcc tccagagctg ataagctttc cttaaaagaa 3528841 tcaggtgcaa tgatgatttt catccaaatc gcctctttca aaacatgatt cacttaacct 3528901 attgatctcc aatgtaccat aattgatctg gaaatacata ccatgcaata tggtaaaaat 3528961 ttaaataaaa attagaaatg aaagtgtttg cataaaagaa atattcacgt tatcatactt 3529021 gtatacaagt atactccttg agtgaggaag gtgagtgtat gctagactcc aaagacctgt 3529081 tgtatcccgc aaaatggctc tcaaaagcgt caaccggagt tcgtgtcgca tacgagctga 3529141 gaatgcggat cgtttcaggt ctgattgaaa gcggtaccat tttatcagaa aatacaatcg 3529201 ccgccgagtt ttcagtaagc cgttcgccgg ttcgcgaagc gctaaaaata ctcgcatccg 3529261 aaaaaatcat ccgcttagaa cgaatgggag cggtcgtaat tggtttaact gagaagaaaa 3529321 tcgcggaaat ttatgatgtg cggttactat tagaaacatt tgtctttgaa cggcttgtca 3529381 aaatagacat tgagccttta gttaaggatc tcagcaaaat tcttgaaatg atgaaagtct 3529441 caatcaaata tgaggatgct gacgaatttt catttcaaga tgtgctgttc catgaaacga 3529501 ttatccgagc gattgatcat tcatacattc agatgatctg gaacaatcta aaacccgtca 3529561 tggaaagctt tattctttta tcgatgcggg tacggttaaa ggaaaagtat gaagacttca 3529621 caaggatttt agataaccac gagctttata ttcaagccat caaaacaaag gatagggcgc 3529681 tgatgattca gtctcttcac caaaactttg atgatgtgca ggataaggta gaagacctat 3529741 ggctctcaca acaaatgctg gcaaaaggag ctgaatacaa caatgactag ttatatgtta 3529801 ggaatcgata tcggcacgac aagcacaaaa gctgtgctgt tcagtgaaaa cggagatgtg 3529861 gtacagaaag aaagcatcgg ctacccgctc tatacaccgg acatctcaac agctgaacaa 3529921 aatccggaag agatttttca ggcagtcatc catacaacag cgagaattac aaaacagcat 3529981 cccgaaaaac ggatctcttt catttcgttc agcagcgcca tgcacagcgt cattgcaatc 3530041 gacgaaaatg acaagccgct gacgccatgc attacatggg ccgacaacag aagtgaaggc 3530101 tgggcgcata agatcaaaga ggaattgaac ggacatgagg tgtacaaacg gacgggaaca 3530161 ccgattcatc cgatggcacc gttaagtaaa attgcctgga tcacgaatga aagaaaagaa 3530221 atcgcttcca aggcaaaaaa atatatcggc atcaaagaat acatttttaa acagctgttc 3530281 aatgagtatg tcatcgatta ctcattggca tcagcgacag gcatgatgaa cctgaagggc 3530341 ttggattggg acgaagaggc actgcgcatc gcaggcatca cgccggatca cttatccaaa 3530401 ctcgtgccga caaccgagat ctttcagcac tgcagcccgg aaatagcgat ccaaatggga 3530461 atcgatccgg aaacgccttt tgtcatcggc gccagcgacg gcgtgctgtc caacctcggc 3530521 gtcaacgcca ttaaaaaggg tgaaatcgcc gtcaccatcg gtacaagcgg tgccattcgg 3530581 acgattattg acaagccgca aaccgatgaa aaagggagaa ttttttgcta tgccttgacg 3530641 gacaagcatt gggttattgg gggacctgtg aacaatgggg gcatcgtcct tcgctggatc 3530701 agagacgagt ttgcctcctc cgaaatcgaa acagcgacac ggctgggcat tgatccatat 3530761 gacgtgctga cgaaaattgc ccaacgcgtc agacccggtt ctgacggtct gctgttccac 3530821 ccatatctcg ccggagaacg cgctccgttg tggaatccgg atgtacgcgg ctcatttttc 3530881 ggcttgacca tgtcgcataa gaaagagcat atgatacgcg cggcattgga aggcgtcatt 3530941 tacaacctgt acacggtgtt cttggcgtta actgaatgca tggatggccc ggtaacccgc 3531001 atccaagcga cagggggttt tgcaaggtcg gaggtttggc gccaaatgat gtcggatatc 3531061 ttcgaatcag aggttgtcgt tccggaaagc tacgaaagct catgtctcgg cgcctgcatt 3531121 ttaggcctgt atgcaacagg aaaaatcgat tctttcgacg ccgtgtccga tatgatcggc 3531181 agcacataca gacatacgcc gatcgaagac tcagccaagg aatacagaac attaatgccg 3531241 attttcatca atctatcaag attattagaa aatcaatata cacaaattgc agattatcag 3531301 aggggcttaa tcacacacaa atagtacatg acatgaaggg gagggcatta ccatgccgtt 3531361 aatcatcgtt gcacttggga tcttagcatt actatttctg attatgggct taaaattaaa 3531421 cacatttatt tccctgctgg tcgtatcgtt cggcgtggca ctggcactcg ggatgccgtt 3531481 cgataaagtt gtcagctcca tcgaagcagg aatagggggg actcttggcc acatcgcgct 3531541 catcttcgga ctcggtgcga tgctgggcaa actgatcgcg gattcaggag gcgcacagcg 3531601 cattgcgatg acgctcgtca acaaattcgg tgagaaaaat attcaatggg ccgttgtcat 3531661 tgcctcattc attattggga ttgcgttatt ttttgaagta ggactggttc tattaattcc 3531721 gattgtcttt gcgatttcaa gagaattgaa gatttctatt ttatttctcg gaatcccgat 3531781 ggtcgcggca ctatccgtca cacacggttt cctgccgccg cacccgggac ctacggcgat 3531841 cgccggtgag tatggcgcaa acattggaga agtgctgctg tacggcttta tcgttgctgt 3531901 tccgacagtg ctcattgcag ggccgttatt tacaaagttc gcgaaaaaaa tcgttcctgc 3531961 atcatttgcg aaaaacggca atattgcatc actcggcaca caaaaaacat ttaaccttga 3532021 agaaacaccc ggctttggaa tcagtgtctt tactgcaatg ctcccgatta tcatcatgtc 3532081 ggtcgcgacc attatcgacc tgcttcaaga aacaatcggg tttgcagata acggagtttt 3532141 agcttttatc agattgattg gaaacgcatc gactgctatg attatttcgt tattggtcgc 3532201 agtctataca atgggcatca agcgcaacat tccagtcaaa accgtgatgg attcttgttc 3532261 aactgccatt tcacaaatcg gcatgatgct tttgatcatc ggaggaggcg gcgccttcaa 3532321 acaagtgctg atcaacggcg gtgtcggcga ttacgtagca gacttattca aaggaacggc 3532381 attatcgcca atcattctgg catggctcat cgcagcgatc ctgcgcattt ctctaggatc 3532441 ggcgactgtt gccgcactaa gcacaacagg tctggtcatt ccgttattgg gccattctga 3532501 tgttaacctg gcgttagtcg tactcgcaac aggagccgga agtgtcatcg cttcacacgt 3532561 caatgacgcc ggcttctgga tgttcaagga atacttcgga ttaagcatga aagaaacatt 3532621 cgccacatgg acattgctgg aaaccattat ttccgttgct ggactgggat tcattttatt 3532681 gttaagttta gttgtatgaa attaagaagg agctgtaaca catgttcaat tcgattggtg 3532741 tcataggctt aggcgtaatg ggaagcaaca tcgccttaaa catggcaaat aaaggcgaaa 3532801 acgtcgctgt ctataattac accagagatt taacggacca gcttatccaa aagctggatg 3532861 gacaatctct cagcccgtat tacgagcttg aggactttgt tcaatcgtta gaaaaaccaa 3532921 gaaaaatctt tttgatggtc acagcgggaa aacccgtaga ttccgtcatc caatcattaa 3532981 agcctttgct tgaagaaggc gacgtcatca tggacggagg aaactcccac tatgaagaca 3533041 cagaaagaag atatgacgag ctgaaggaaa aagggatcgg ctacctggga gtcggcattt 3533101 ccggcggtga agtcggtgcg ttaacagggc cttccatcat gccgggcgga gatcgcgacg 3533161 tctatgagaa agccgctcct atcctgacga aaatcgcagc ccaagtcgga gatgaccctt 3533221 gctgtgtcta tatcggacca aaaggggcag ggcactttac aaaaatggtg cacaacggca 3533281 ttgaatatgc cgacatgcag ctgattgcag aagcttatac gtttctaaga gaaacgcttc 3533341 gtctgccgct agatgaaatt gcatctattt ttgaaacatg gaatcaaggt gagctgaaaa 3533401 gctatttaat agagattaca gctgagattt tacgcaaaaa agacgaaaaa acaggacagc 3533461 ctctgatcga tgtcatcctt gataaaaccg gccaaaaagg caccggaaaa tggacgagca 3533521 tgcaggcgat tgataacggc atcccgtcca cgatcatcac agagtccttg ttcgcccgct 3533581 acttgtcatc tttaaaagaa gaacggatgg cagctcaaga tgtattagca ggcccggaag 3533641 ccgaagaaaa acacttggat aaagacactt ggattgaata cgtcagacag gctctttaca 3533701 tggggaaagt atgcgcctat gcacaaggct ttgcccaata taagatgtca tctgagcttt 3533761 acggctggaa tctgccgctc aaagacatcg ccttgatttt ccgaggcggc tgcatcatcc 3533821 gcgctgattt cctaaacgtg atcagcgaag cattcagtga gcagccaaat ctggctaacc 3533881 tgctgatcgc gccttatttc acagataagc tccatgccta tcaaacaggc ctgcgaaaag 3533941 tcgtttgcga gggtatcagc accggaatct ctttcccatg cttaactacc gcgctctctt 3534001 attacgacgg ctaccgcaca gggcgttcca atgcgaacct cttgcaggca cagcgcgatt 3534061 actttggcgc tcacacgtac gaacggactg atatggacgg cgtcttccat acgaattggt 3534121 ctgaataacc tgtattaaaa acacggtcag tttcaactga accgtgtttt tttcttctat 3534181 cccaaacaac agaagacata agttatgttt taaatatcat aaacagtgat acaataatag 3534241 ctagaaacaa tccccaagat catcatgtga cagcagattg ctgttccgtt ctattctgct 3534301 tttggccatt gtcctttgcc cttgaccatg gtgtcataaa atgttcaaat gccaaaacgg 3534361 cctggcattc tgatttacaa aagtccctga aaaccttatc taattgagaa tcagcctctc 3534421 atttattata aaagaaatgc ctaaatccta cctgtcacac ctttattaag atgaaaaaaa 3534481 gtaggttatg gcttgacaaa aaatatatat taattaataa ttcatatata attagaatta 3534541 ttattgaaag cgattatgct ttctaataca tttttaggag gaatatacat tatgtcttta 3534601 atcggtaaag aagtacttcc attcgaagca aaagcattca aaaacggtga attcatcgat 3534661 gtaacaaacg aagatttgaa aggccaatgg agcgtattct gcttctaccc agcagatttc 3534721 tctttcgtat gcccaactga gcttgaagat cttcaagaac aatatgctgc acttaaagaa 3534781 ttaggtgttg aagtatactc tgtttctaca gatactcact tcgtacacaa aggctggcat 3534841 gacagctctg aaaaaatcag caaaatcact tacgcaatga tcggtgaccc atctcaaacg 3534901 atctctcgca acttcgatgt tcttgacgaa gaaactggcc ttgctgaccg cggaacattc 3534961 atcatcgatc cagacggcgt tatccaaact gttgaaatca atgcaggcgg tatcggccgt 3535021 gacgcaagca accttgtaaa caaagtaaaa gcagctcaat acgttcgtca aaacccaggt 3535081 gaagtttgcc cggctaaatg ggaagaaggc ggcgaaactc ttacacctag ccttgatcta 3535141 gtaggtaaaa tctaaggagt gcattcaatt ggtacttgat gcaaatatca aagcacaatt 3535201 aaatcaatat atgcagctaa ttgagaatga cattgttctc aaagttagcg caggcgaaga 3535261 tgacacttct aaggacatgc tggctctcgt tgatgagctg gcttccatgt catcgaaaat 3535321 ttcagttgaa aaagctgaat taaacagaac gccgagcttc agtgtcaatc gtgtcggaga 3535381 agacactggc gtgactttcg ccggtatccc tctgggccac gaattcacat cattagtgtt 3535441 ggcgttgctc caagtgagcg gcagaccgcc taaggtagac caaaaagtca ttgatcaggt 3535501 gaagaagatc agtggtgaat accacttcga atcttatatc agcctgacat gccacaactg 3535561 tcctgatgtt gtacaagctt taaacatgat gagcgtgctg aacccgaaca ttacgcacac 3535621 gatgattgac ggtgcagcat acaaagcaga agttgaaagc aaaaacatca tggcagtgcc 3535681 gaccgtttac ctgaatggcg aatccttcgg aagcggccgt atgacgcttg aagaaattct 3535741 tgcgaaaatg ggcagcggca cagatgcatc tgagtttgct gacaaagagc cgtttgacgt 3535801 tcttgtggtc ggaggcggac ctgctggtgc aagtgcagcg atctacactg cacgtaaagg 3535861 catccgaact ggtgttgtcg ctgagcgctt cggcggacag gttctcgaca ccatgagcat 3535921 cgaaaacttc atcagcgtca aagcgacgga aggaccgaag ctagcggcaa gtcttgaaga 3535981 gcatgtgaag gaatatgata ttgatgtcat gaaccttcag cgtgcgaaac gccttgagaa 3536041 gaaagatctg ttcgaacttg aactcgaaaa cggcgctgtc ctgaaaagta aaacagtgat 3536101 cctttcaaca ggtgcacgct ggcgcaatgt caacgtcccc ggtgaacaag agttcaaaaa 3536161 caaaggtgtc gcatactgcc cgcactgtga tgggccattg tttgaaggca aagacgttgc 3536221 ggtaatcggc ggcggaaact ctggtatcga agcagcgatt gatcttgcag gtattgtcaa 3536281 tcacgttact gtactagaat tcgcgccgga actgaaagca gacgaagtcc tgcaaaaacg 3536341 tctctacagc ctgcctaacg ttactgtcgt gaaaaacgca caaacaaaag aaatcacagg 3536401 tgatcagagt gttaacggca tcacatatgt agaccgcgaa acaggcgaag aaaaacacgt 3536461 tgaacttcaa ggtgtattcg tccaaatcgg tctcgtgcca aacacagaat ggttagaagg 3536521 aacggttgaa cgcaaccgca tgggcgaaat tattgtcgac aaacacggcg caacaagcgt 3536581 accaggctta tttgctgccg gcgactgcac agacagtgcg tacaaccaaa ttattatttc 3536641 tatgggatca ggtgcaactg ccgccctcgg cgcgtttgat tacctaatcc gtaactaata 3536701 taagaaatcc gctatattgc cagattggca ggatagcgga tttttctttt tctacagaaa 3536761 aaaaccgaac caggcactac ggtaaaagtg ctcgattcga gcgcttctta tagttcctca 3536821 ccattcgttt gaatgacatt tttataccac tcaaaggagt ctttcttata tcgtttcatg 3536881 gatccgtttc cttcattgtc acgatcaaca tagatcatgc cgtagcgttt tttcatttcg 3536941 ccagttgtga aggagacaat atcaataatg ccccacggcg tgtagccaat taaatcaaca 3537001 ccatcgtacg tgaccgcttt tttcaatgct tcaatatgcg attttaaata ttgaatgcgt 3537061 tccggatcat gaaccttgcc gtcctcctcc agcgtatcca ctgcgccaaa gccattttca 3537121 acgatgaata acgggatttg gtatcggtca taaaaacgat ttaacgtata tctcaacccg 3537181 gttggatcaa tcgcccatcc ccagtcactc gaagtgatgt acggattttc gacaccattc 3537241 ggcaagccgc catttacaat atcgccagtg ttatcatttt tcacatcgct tttcacagtt 3537301 gttgacatgt aatagctgaa gcctaagtaa tcgacggttc cgtttcttaa aatctcatca 3537361 tcgccgtctt cgaatgtgat gttgtagcct tcgcgttcaa attccttcaa cgcgtagctt 3537421 ggataataac cgcgaacctg cacatcaggg aagaaatagc gctgcctcat ttcttcttca 3537481 gccagcatca catcttcagg attggaggag aaaggataaa tcggcacgtg tgataccatg 3537541 gccccaatct ggaactctgg attgatgtct tttccttttg ccactgctaa ggcgctcgcc 3537601 actaattcat ggtgcgccgt ttgatacatg acttccttgg cgttttcgtt ttcgccaacc 3537661 acaacacctg aattcgtcca taggaacagc ggattgttca catccatttg gttgttaatc 3537721 tcgttaaatg tcatccagta cttcacttta tctttgtaac gggtaaagca agcctctgcg 3537781 aagttgacga agaagtccac gactttccgg tttctgaagc cgccatattc tcttgccagg 3537841 tgcagcggca tttcaaagtg agacagggta atgaccggct cgatcccatg cttcagcaat 3537901 tcatcaaaca catcatcata aaactgcaaa ccagcttcgt tcggttcagc ctcatcgcct 3537961 ttcggaaaaa tccggctcca gccgatggac gtccgcagac attttaatcc catttccgca 3538021 aacaaagcga tatcttcctt gtatctgtga tagaaatcaa tggcttcatg gtttggataa 3538081 aattcgtttt cttcaatcgt gtcagtgatt tttctcggca cgccgtgcgc acccgctgtc 3538141 atcacatcga cgacactcgg ccctttaccg ccttgattcc atccgccttc aaattggtgg 3538201 gcagctaaag caccgcccca taaaaaatcc tttggcatgt ttcccatgtt taattcctcc 3538261 tcagcttacg actgtaaata ttttttgatg taatgcactt tcctcaatgt cttcaatgaa 3538321 agctttatca aactcaacaa gcacttcgcc ttttttgacg gtatcgcctt cttttacctt 3538381 caaggaaaaa ggcgtgccgt caaatgtcac cgtatccagc ccgatgtgcg caagcaattc 3538441 gacgccggac gctgaacgca ggccaatcgc atgctttgta ggcgtaacca tgacaaccgt 3538501 aatgacgccg ggatggtagc atcgatttca cgatatcctt cgctttaggg gtagaccgct 3538561 tcagcaccaa tcgaagtctg gtagcgcagc gagaagcccc aatcacattc tcttccccgc 3538621 ctacggcctc taaaatgtct tttgctagtc tcgtataatc tctcactttc cccgacattt 3538681 cacccacccc ttcgttttgg ttacgctttc attataattg taacggtata atttatcaat 3538741 tccgaaacaa aatatttacg cactaactat cattgtaagc ggtttatgct ataattttga 3538801 caagtgaaac taaacgaata aatgaggaat gcgtatgtta aaataccagc aaatcgcaac 3538861 ggaaattgaa acatatatag aagaacacca gcttcagcag ggagacaaac tgccagtcct 3538921 agaaaccctc atggcccagt ttgaagtcag caaaagcacc atcacaaagt ccctcgagct 3538981 attagagcaa aaaggcgcga tctttcaggt cagaggaagc ggcattttcg tcagaaaaca 3539041 taaacgaaaa ggctatatca gccttctgtc gaatcaggga tttaaaaaag atctcgagga 3539101 tttcaacgtc acctcaaaag tcatcgaact ggacgtgaga aagccaacac cggaagcggc 3539161 ggaaaacctg aacatcggaa tggacgagga catctactat gtcaaaaggg tccgctacat 3539221 caacggccag accctttgct acgaagaatc ctattacacc aaatccatcg tgacgtattt 3539281 aaacaacgaa atcgtctccc actccatctt ccattacatc cgggaaggac tggggttgaa 3539341 gattggtttt tctgatttgt ttctgcacgt gggccagctt aatgaggaag aagcggaata 3539401 tttgggatta gaggctggac tgccgaagct gtatatagaa agtatttttc acctgacaaa 3539461 tgggcagccg tttgattact cgaagatttc gtataattat gagcagtcgc agtttgtggt 3539521 acaggctaat agttttttat tatagggctc ttcactacgg taggtggtcg acatgtacaa 3539581 aattatcatt cctgccatac tagccatctt tgcgctctgg atactcttac agatttcact 3539641 agagatgagc atcgttaaga atccaatgaa ctactttatc gtattcatta tctttttcct 3539701 ctttgtaaag atggtgaaag aaaaacaata atagtttggg cgatgcaaac agaaaaacat 3539761 ccttccctta acaaactcag ccagtcacat gcattaatct tgatgttaat gatatatagg 3539821 tgcacataaa aagctacttc attgtgaagt agctcccttt attaaaggcc cattttgatc 3539881 catctagttt tagaaaagcg aaggacaatc gcatttatga taataattga aactaaatac 3539941 aaaataataa ataaaacatc attactccca agtgtcatgt tatcagattg cagcactctt 3540001 tctattcggg ggtacatagt gttacctgcc tcaaaaggag caatgaaacc aaacgtttta 3540061 ttgcttatag ctactaagat aacagaagtc atccaataaa cgatactgac acctatacta 3540121 attaatatat taggacataa cacgcttata gttccgataa ttagaatata ctgcagtata 3540181 actgcagaaa ataaaaaaag taataatgca aaatgcgaaa aatcatggta catcaacgat 3540241 atgattagca ggcctagcgt tataaatgca aaacattcta aaaataaaac agctatcttt 3540301 ttataaaaga aagtatagat gttctctcca attaacttgt aaaagagaat atttttgttt 3540361 gaatactctc tattaataaa gaaagctata acaaatgaaa ataacatcaa accaaactgg 3540421 gtcgcaacag tataggagct aaagaaaaac atttcaggtg taacattact gactttatcg 3540481 attccaacaa gtaaaaaata acccagcaaa aataaaaata caaacattgc tcctaaaata 3540541 atgataactt tgttgctaat actcttttta aactctaatt tcatctcaag cccccactgt 3540601 tttattactc atttatatac acttcaatta atttatccac tgaatgatat tgttgaattt 3540661 cttggtgatt aaatatataa taatcccctt ctatcgcctt taaatcagac aaatcatgtg 3540721 taatgttgat gataatcttc tcggggttct cctgaatata cttgtttaag aagccatgaa 3540781 tctctataac cgtttttttg tctaatgaat tcgttatttc atctaaaaca ataatatttt 3540841 tatcctctaa taagaaactg agcaatttta atttttgctt ttgtccatca ctcaaatttt 3540901 tgatcagaac ttttccatca atattatcca gattaagtaa atatgcgatt ttatctatca 3540961 tttttgcatc aaatttttta ctcaaaaagt gtaataaaaa gtccttagaa acatcattag 3541021 gtatattcga cgagctggat attaaagaaa cattttgacg aatatctctg ccgattcttt 3541081 tgctattatt caacaaaaag tctttagcaa gctgtgattt accgactcca ttttttccga 3541141 caacgtgatt aattttcccg ctcgaaaaat gcaagtcggt gtcctgaagt aacgttttgc 3541201 ctttcacttt taaagtgtaa ttcgctatat tcatatacat actcctagga aatatttgca 3541261 taataataaa atgttctgcc ttgtgatttg ttactaatgt ctaagctttt gaggtacctc 3541321 tttcgtttcc gatccggaag cgaaagaaat gtttttagat ggctaatttg gagatctttt 3541381 actctagttt acaatatata atatccaatg tacaactgaa ttcactgcaa ggccaatccc 3541441 tataatttga atcgtaagaa ctaaccaatg atttgtctta aaacggctat attcatctaa 3541501 gctcagaaaa gctaaaagaa ttttgtaacc atcagaattc aatattggga ttaagttcca 3541561 caataaagta gacgagaaaa gcataaatgc catagttaat gcttcactgg aaaatgtaaa 3541621 ttgatttatt aattctaatg tatttattaa aagataattg ataaacaagc caaataaatg 3541681 aacgattatc ttttcatttc ttgatagcat gtaggtttca ttcaattgga cataaaaagc 3541741 aggaaataca taaaaattca gtttgaatcc cactttatca aagtttttcc cgaaaaattt 3541801 taaggaataa atatgtccca gttcatgaag cactatattc attataaaat aaataactat 3541861 aattatccac attttccagc cgtaaaatac tgaggacaat ccattttgca attttattaa 3541921 atgaatataa tttaatatga acatgagagc cgtaaaggat aagaacagat aaaaaaactt 3541981 tggtgatact ttctctttat acattttaaa acgtaataat tgtttatctg acagagaatt 3542041 taaactattt ttatagtatt ctccgctttt tttgtctttt ataaatacgt tgttttgcac 3542101 aagcacttca tatttttcat cttcatactt taaaattttc attatagtat ttttccatat 3542161 aaggatagaa gtagtttatt ttttctgcag agttgaataa ggaaccacaa actccacaaa 3542221 tagaggaaaa ttcataagga atgtcaaatt cctctatttt gttattttct tttaaaatat 3542281 tcaaaaacca tttgaatcct tcttttctaa gaataaataa tagcaaattg gaatttaact 3542341 tttccacggt tctttcgaaa ctttggttat attcttccct tagggttatt ttcgtttcaa 3542401 aaatagcagg ggaacaacat ggataaattt ctccatcatg atgatataca atgtcatatc 3542461 cgggacaatg taaggaatct tcatcttcaa gactgtaaaa tttatgtatg ttttcttgct 3542521 taattctagt tttagcagcg ccaactgata tcattggaaa ttttgttatc tttacaccta 3542581 agattgaatc ccccaattcc tctaaaatgt ggttggacat tttgtctttg gtaactgcca 3542641 tattaagaga aatatcgata tcagggtatt tcctgctatg ttctaatatg tttttaatac 3542701 tggaagactt gacaaatgga gcatggtact catcataact tatagtcagt gctatcacat 3542761 ttaaagaatt catatcatga aagtactcct ggaccttttt cttgctcaaa ccccaaaatc 3542821 cattagagat caacgttatt tgtttttcat atggtttaat gatttccatt agttctttta 3542881 aaaatttata atctaaaaaa acttccccac ctgtaaaaga aatcacttga atggttttgt 3542941 tttttgcaaa ttcagttact aactctctta tgtattcttt ttccatcctg gttgttgaag 3543001 ttggtgaact agaaaaacaa caatggtcac aggatgcatt acaccttgaa tctaaattga 3543061 ttgatactgt tttattatac atgaaatatc ccccaacaaa tggtaaagga gagttagact 3543121 ctcctttgta cccctctaat taatgaccac ttccaagaat ccagcgattt tcttttgatt 3543181 ttacaaaata ccaaagatca ttcacttttg ctaacttttg tgattcatct aatagaccct 3543241 taaattctaa gtttttcaca gtctcattgt tagtgatttc ctttttcata ttatccctcc 3543301 tccttttcta atataaacca attattctat atcattcaat acatgtcaat atattgtacc 3543361 taaaaaatct gaaaaatgtc actattcttg gtatataaag cctatagtcc tctagcccct 3543421 ctaagctata ccgaatgaaa ggccatagtt tgatttaaag cttcgtaatg aaaagtaaaa 3543481 catcaatatt gactacacta gttaagggat atacagattt taagtggaag aaatgaggca 3543541 aacaatctta ccctaaacca acctgtactg aaaagctgtt ttaagctctt gcttacccca 3543601 tttggcacct ctttctctcg ttttaattgt ctctaaaagc agttatgcgg tactatcata 3543661 taaaggtcca atgtttaaaa ataatgtcat acttttaaat tcaccttatc atgcacatgc 3543721 tcataaagag gggtttattc taaaaagggg atggacggtt ttggaaagca agtacctaga 3543781 tctactcgca caaaaatacg attgtgaaga aaaagtggta acagaaatca tcaatttgaa 3543841 agcgatattg aacctgccaa aaggcaccga gcattttgtc agtgatctgc acggagagta 3543901 tcaggcattc cagcacgtgt tgcgcaatgg ttcaggacga gtcaaagaga agatacgcga 3543961 catcttcagc ggtgtcattt acgatagaga aattgatgaa ttagcagcat tggtctatta 3544021 tccggaagac aaactgaaat taatcaaaca tgactttgat gcgaaagaag cgttaaacga 3544081 gtggtataaa gaaacgattc atcgaatgat taagctcgtt tcatattgct cctctaagta 3544141 tacccgctcc aaattacgca aagcactgcc tgcccaattt gcttatatta cggaggagct 3544201 gttatacaaa acagaacaag ctggcaacaa ggagcaatat tactccgaaa tcattgatca 3544261 gatcattgaa cttggccaag ccgataagct gatcaccggc cttgcttaca gcgttcagcg 3544321 attggtggtc gaccatctgc atgtggtcgg cgatatttat gaccgcggcc cgcagccgga 3544381 tagaattatg gaagaactga tcaactatca ttctgtcgat attcagtggg gaaatcacga 3544441 tgtcctttgg atcggcgcct attccggttc caaagtgtgc ctggccaata ttatccgcat 3544501 ctgtgcccgc tacgacaacc tggatattat tgaggacgtg tacggcatca acctgagacc 3544561 gctgctgaac ctggccgaaa aatattatga tgataatcca gcgttccgtc caaaagcaga 3544621 cgaaaacagg ccagaggatg agattaagca aatcacaaaa atccatcaag cgattgccat 3544681 gatccaattc aagcttgaga gcccgattat caagagacgg ccgaacttta atatggaaga 3544741 gcggctgtta ttagagaaaa tagactatga caaaaatgaa atcacgctga acggaaaaac 3544801 atatcaactg gaaaacacct gctttgcgac gattaatccg gagcagccag atcagctatt 3544861 agaagaagaa gcagaagtca tagacaagct gctattctct gtccagcatt ccgaaaagct 3544921 gggccgccat atgaatttta tgatgaaaaa aggcagcctt tatttaaaat ataacggcaa 3544981 cctgttgatt cacggctgta ttccagttga tgaaaacggc aatatggaaa cgatgatgat 3545041 tgaggataaa ccgtatgcgg gccgtgagct gctcgatgta tttgaacgat tcttgcggga 3545101 agcctttgcc cacccggaag aaaccgatga cctggcgaca gatatggctt ggtatttatg 3545161 gacaggcgaa tactcctccc tcttcggaaa acgcgccatg acgacatttg agcgctattt 3545221 catcaaagag aaggaaacgc ataaagagaa gaaaaacccg tattattatt tacgagaaga 3545281 cgaggcaacc tgccgaaaca tcctggcaga attcggcctc aatccagatc acggccatat 3545341 catcaacggc catacacctg taaaagaaat cgaaggagaa gacccaatca aagcaaacgg 3545401 aaaaatgatc gtcatcgacg gcggcttctc caaagcctac caatccacaa caggcatcgc 3545461 cggctacacg ctgctataca actcctacgg catgcagctc gtcgcccata aacacttcaa 3545521 ttccaaggca gaagtcctaa gcaccggaac cgacgtctta acggtcaaac gattagtgga 3545581 caaagagctt gagcggaaga aagtgaagga aacgaatgtg ggtgaggaat tgttgcagga 3545641 agttgcgatt ttagagagtt tgcgggagta tcggtatatg aagtgagggg tgtggggttc 3545701 agggatggtg atatgctgct cccctaaaag tagatagatg aattttagaa aatctgtttg 3545761 ccttggggag ttttttcatg gctggacaat tatactacaa ggaagaaata ctaatactta 3545821 tagaatgtaa ttgggtaatg attcggagaa agaggttgcg aaataatatg gtattacact 3545881 gaaacaatta tcaatggaga acatgcacga tatagccgtt ctatattctc cctctattat 3545941 ggcactcatt agtagacata accgtaaaaa aatgcactca aaaaaagtcc attctatata 3546001 actctcgcta gggtggacct ttttcaacat tcaaagtact agattttttc tagtgaaaga 3546061 ataagaaaag acataagttc tattttatca ctctgttata ggttaagtta ttacggtgtt 3546121 tcattatata ctgaatttaa acacccttga cattatggga atttttaaaa caggttaaaa 3546181 ggaagttcta taagaactcc ctagtttaat attatttggt caaaatctaa aaccaaaaaa 3546241 tctattttta tcttcattgt ttctatctaa ttttgcaaca atcatacctt tcgactctaa 3546301 ttcttgaagg tcatctaata ataattcatt tttatttatt gttacaaaat attgtccgat 3546361 cctattctct aacagacttg aattgatatg ttttaataat gtacctttta catgaggatc 3546421 aggattagaa taagatccgt catgaattaa aatattcaaa ctacacttat ttatacacct 3546481 gtataaaaac caagtaagat caaatatatt tatcttcata tggagtctac catgtgaacg 3546541 ttcatccggt atagaacaag aaattttgat ccttcctgta gttgattgtt ttgcgttact 3546601 tattctatta tcatattcaa aatctaaaaa tccatgttgg ttgtatgtaa catccattag 3546661 attattaaaa agcttcttta actcactaac tatagcgcta taagattgaa actcatcata 3546721 atacattgaa ttaactctta atatttcatg ttgaagttca ttaatcttat caaaaatatg 3546781 gtttttttta tcgtagtcac taattctcaa tcttacttcc gctaactcta tttctttcct 3546841 tctttgttct tccatcacaa tggaaatatc ctcaatgaaa ttgttactct ttaaaattct 3546901 ggcacttgat tccagttgtt ctgttaatcc ttgctttttg atattaagtt tttttaaatc 3546961 ggcttgtatt ttaacaattt tatctttaaa ataactccct ctactttcta ccatgaaatt 3547021 atagaactct tggactttat tataattctg ttttacttcc tctggaaaaa aacctacaat 3547081 atcttcatag aatttttcta tattttctaa ttctttaatc ttagttactt ttttatttaa 3547141 atcatctata tttctttgat attgtttaca aatatgttca ttttcaaata tttcattttg 3547201 tattttatta agttcacttt taatttctga gtacctattt gtatcattat tatatttatt 3547261 ggcagtctta gtttgataga taactctatt gtaatcctct atctcattta ttaattcatc 3547321 ttccttaact tttaaatcgc caatgttaat attcattgat tcaatcaatt ttatttcact 3547381 atttaatttt tcaatcttat cccgaaaaac ctttatgttt ttttctgtat gagttggtaa 3547441 agtaaaaaga tagttaagta atttatattg ttttaaccct cccctattcg gtaaaactat 3547501 atcattaaac cctgtctttt cgtctcttat aatatactcc cttaacgccg caaaagttat 3547561 atcctctttc tcacccttta aaatttcctt ttcaataaat tttttatata cacttatact 3547621 aacttttttc cattcctcca aattaaaagt taaagaagta tcatgtaatg tataaccatg 3547681 tttaggagaa ttaaaagatc tagcaaggaa tacttgattt ccatcaattt ccacattcaa 3547741 aacaataaaa acgtttttat tgagaagaat ttcatttgtc gtataaaaat ttgatatagt 3547801 cttccctagt aaaaaggaga tgcattcaat catcgttgac ttacctacac cattagtctc 3547861 ttcatgatct tctctctttt caccaagtat tatatttact cctacagcat taaatttata 3547921 ctctttcaaa atttcttggg aattgcaaac aaaaagattt tttataatca taacaatcac 3547981 taactctccg ttctgctaat catattttga ttaaaagaaa ctttacctaa tgaatataaa 3548041 aaagttaacg ataaatacag tatccgttca atattcaaat ttattataat accttgactc 3548101 ttagcataat caagaaaaag ttgatcaata tgtttttcct tctctaacag ttcataaagt 3548161 atctttgatg agtataaaat attttcttcc acagcattat atttagttaa taaaaaatga 3548221 ttcatttctg gcctctccgc cttttccttt tttaaaggag aattattcac tagaggaata 3548281 agatcatttc caatttgaat gtttttaaac tcattttcta ataaaacata agagtatttg 3548341 agaatatttt cagctgtttc aattttaaga tcaatcattc ttaacacttc ttttgttatc 3548401 attaaaaatc tcacattcat aaatgcacca acatgttaaa atcttaatgt attttttcgt 3548461 taaagccttt gaatatggta aaactgaatg acattctaga taaatctcat taacaatttt 3548521 tacaaatatc tcatctccat tattatattg attatgaaac tctagatatt tgtctactat 3548581 cgtctcagca atcaattcct ttttatcagc acttacatac gaagtggaat ccattatatg 3548641 gtttatcaca ccaaaatact cagaataact atcgaatttc cgtttaaaag tttccccact 3548701 tttcatatca taaaattttt tatctaaacc aatttgatta tcaaaattac tagtaaatgt 3548761 tttataactt tctctatact catgaaaatc tataataaag ctcttaaact catcttcatc 3548821 aattttatca tcgttatctt ctatttcttt ttcaataagg ctctctaatc tattaatctt 3548881 ataatttaac ttcccttcct gtagtctcct tcctccttgg ttgttttttg accagtattt 3548941 atattcggta ttccaaatgt agtatgttac ttctgtctcg ccattatcta aattcacatc 3549001 caccgaaata aattctggag tagcatactc atcctttata atggctccac ttactaattc 3549061 taagaatgga ttttcatttg tatttgcagt aatattaaat gaagaatcat gtacatgtcc 3549121 tgccaaatat agatcaataa agtaatcatc aaaatgtgcc tttattgatt ctctttcgga 3549181 agattcaata caacctaacg tatggtgccc aatagctata tttaatacct tgcccttatt 3549241 tttctctttg ttcatcttcc ttattgcttt atataatttc atctgtgcag ttaataacgt 3549301 tccttcttca ccttttttat ctgataacag acatgtattt attgataaaa cattatactt 3549361 ctccgattga tacaaaaaat gcaaatcttc ttccggatat ttaacaccca taaaatcttc 3549421 ataaaaatcg aaaaatttcc tttgaccttc cactaatata tttgtagctt tttgatctag 3549481 tttatccaac atttctgagg ggttaggaga tttcataata ctatcaatca aaagtgtcct 3549541 cgtcatgtct ctagatatat cgtgatttcc tggcactaag tgtacgttat tcttacttaa 3549601 tcccatactt ttaataattc cattaagata ttctttaaca tcttcgttat acacatcacc 3549661 tttgtgtgct atatctccag ttaataataa aaaatcaaaa tctgactctc ttcttaaaac 3549721 ttctataaaa tctaataatt tatctctcat tacaatagtg tcataatttt gaaactgaaa 3549781 atgcaaatca gaaatttgta aaaaacgtac cttcaataca aacatcctct cataagtata 3549841 tttatcccct atatatttct agaaaacttt ttattctata tcatctttac tctttaatat 3549901 attaagactc tttccacacc atcaaataaa ttataaccta aacataactc tttactcatt 3549961 ttagtattgt atttaagtca aacattgcat tggttgctga aatattatat tcattgaatt 3550021 attccattaa atagctttta gttgaacttt agtctttctg taatggtgga gatgctctta 3550081 cttatgataa ggctccccac gattaatccg aaaagcccga taaatctgct ccactaaaat 3550141 aagccgcatc aactgatgag gaaatgtcat cttcgagaac gatagcttct cgtccgctcg 3550201 cttcatcacc gtgtcactca atccgagtga tccgccgatg acgaaggtga ctttgctttt 3550261 tccataagta gccagcttat ctattgtatc ggctagttct tcggatgttt tcatttttcc 3550321 ttcgatggcg agggcgatga cgtgggcgtc ggggctgatt ttggatagga tgcggtcgcc 3550381 ttctttgtct tttatgattt tcatgtcctg gtcgcttagg ttttccggcg ctttttcgtc 3550441 cgggagttcg atgatgtcga tttttgcgta ggccgaaagt cgtttggtgt attcttcaat 3550501 gccttgcttg aggtattttt cttttagttt tccgattgtc acaatattga tattcacagg 3550561 tcatccccac tttaaaaaca agttattcat atatgttgtc cacaattgtg gatatctttt 3550621 ctgtattttg tgtaagatca ttcgttcccc actatatata ctgcggggtc tccacataat 3550681 tcacaggctg tggataaact gttagtatgt tcgatttttc tgatttcggg cggcagctcg 3550741 tggtcgtcta tgtacatatc cagcaccgtt tcgatgtgtt cttcacaaga ataatacgct 3550801 tgtttcatgt tcaaatcctc cgatgttttc ttccattttt acaaatgttc tcttctcaat 3550861 ataacctatt tattcacatg ttagtagtgc ttcgggctga gttttatcca caattcgaca 3550921 aacaagctgt tgatgactct atttcgctcg tgtgttagtt tggatgtaac cgatgtgtgg 3550981 ggaggtctgc atttgcgctt tagatgggtt tggctttttg tgattatgtt gctgcttgct 3551041 gagtgtcagc catcttattg ggtgttggag aaggatcgaa tcggtgaagg cagtccagac 3551101 ttagaaatat acgctaatta tctccaaatg catgatgacg tgaaaggata tcaagtcttc 3551161 accatatcag aaggcaaaaa aatggtcgtc gtgtctctcg gaagcagcga gaaagataag 3551221 aagcttgaag tgtcggacgt caaattctca tctaaagaaa cgattgtaac tgtggagcga 3551281 aaacctgctc ctacggcaaa tgagaaaaac ccttttattt tgattggact ggacaaaatt 3551341 gaaggggatt taattgttca agacgaaaca ggagatcgct ttgaagaaac ggattaccag 3551401 caataaagcc ggcgttctga gaacgtccgg ctttttcttt tacttcaatg tcccatgcgg 3551461 gtcgatgacg aattttttgg ctgcgccttt gtcgaagtcg ctgtagcctt ttggcgcgtc 3551521 gtccagagaa ataacggtgg cattgacggc ttttgcgatc tgcgctctgc cgctcaggat 3551581 cgctttcatc aaattgcggt tgtatgtcat ggcgggcgtt tgtccggtga cgaaggtgtg 3551641 ggctttggcc cagccgagtc cgaagcggat ttttaatgag cctgttttgg cgtccgcatc 3551701 ctttgcaccg ggatcttcgg tcacgtataa gcctggaatg ccaaggctgc ctccgacctg 3551761 ggtgacgtcc atgattgagt tcagcacggc ggctggcgct tctccttgat tgccgtgccc 3551821 agatgcttca aagccgacac agtccactgc agcatcaacg gttggttcac ctagtatttg 3551881 ttcaatttgc tcgccgaggc ggtcgtgttt ttgcacgttg accgtttcac agccgaagct 3551941 tctggcctgt gccagcctgt cttcgttcag atcgccgaca atcacggtag aggcgcctag 3552001 gagctgagcg gagtgtgcag ctgccaagcc gacaggaccc gctccagcga tataaacggt 3552061 tgaacctgtt tgcacgcccg ctgtataagc tccatggaag ccggtcggaa aaatgtcgga 3552121 cagcatggtc aaatcgagaa tcttttctag cgcctgttct ttatcaggga ataccaaaag 3552181 ctgaaaatca gcgtatggca ccatgacata ttcagactgg ccgccgaccc agccgcccat 3552241 atcgacgtag ccgtaagccg atcccggccg gtccggattg acattcaggc acacatgcgt 3552301 tttctgcgtt ttgcacatca cacagcgtcc gcaggcaata ttgaaaggaa cggatacgat 3552361 atctcctttt ttgataaatt caacatcacg ccccgtttca atgacttctc ccgtaatttc 3552421 atgcccgagc accaagcctt ctggcgccgt tgtgcggcct ctgaccatat gctggtcgct 3552481 tccgcaaatg ttggttgtaa tgactttgag aataacccca tgctcacatt ttcgattcac 3552541 attcgccttc gggacgccgg gcccgtccct caagattaac tccggataac cgatatcctc 3552601 caccgctaca gtccctttgc ctttgtacac aaccgctttg tttcctgtca acgccattcc 3552661 tcccattcat gtgtttggac tctccgtcct tgaacatgac ttcggttcgg catgactctt 3552721 tccctttttc acgactgttt tttctgtatt cttacaacaa caaatatgcc aagaaagcat 3552781 ccaataatgg ttccgccgat gtctaagaag tcgactttac atccatttaa caagaacaca 3552841 gtaatggccg aaaccaggca gatcataact gccagaagaa taacccgatt tgtctgcatg 3552901 taattcctcc tttggattcg tttctaaacc atacccaaaa tcctctgcaa acttcggttc 3552961 aacaaaaaaa gagacttcac accagtctct tcataaacag agatcactca aaaaatttcc 3553021 tgagaaataa tgtggcaaca ctcgttacta acgcaattgc cgtatacata acaacccaaa 3553081 atatgaatga gctattcccc gaagctaacg taactaacaa tatcaagctc gtgataagaa 3553141 cgatgagcgg tgccacccaa aatcttttaa ataaaaaatg acccgctata ccaaatacac 3553201 ctgcgacgat cggaaaacca aaaacgataa ataaaacggc gatggctccc atactaccct 3553261 ccttgcctta aaacctcttc atcacctcaa catcatacag cttcaaatga ctcttcggcg 3553321 tcacgacatc ctttaccttc ccaatctctt tttctttcat tttctttccg gttttcaggc 3553381 tgtactgttc aatgtaggca ggcttgtgat acgtgtatgt gaagaaatag aggctgctgc 3553441 ctttttgggt gatttctttg aattcggctt tcattttgtc cggggaaagg gtgaagacga 3553501 tgcttgtttt tcctgtcttg gcatcgattt tgtgtacctt tccgaagccg tcaatgaaat 3553561 acaggttccc gtcataaggg aaaaagctgt ttttaaagct gaagggcatg gagctgtata 3553621 tcgtttgttc gtcgtttttg tattcggcga tatcgtgcag ctctacttcg ccgctttttt 3553681 tgttgatctt gaccatttga tagagatcgt gggctttttg gccgcgaacc ataacataca 3553741 cagcttggtc gtccacggca agttgggatt cgactgaggc tccttcccgg tactgccatt 3553801 ccgttatgct gagataggta agcttcttct gatctgcttg aatctgaagg agctgatagc 3553861 cttttccgtc atctgtcggg acgagtgcgt aaatggcgcc atcatggaaa ccggaggctc 3553921 ggatgtagta ggggatgacg tcttttttcc actctccgtc catttggcgg tacagctctg 3553981 agcggtatcc gtctcccttt ttgtcgtagc cggagttgta taaggtgtaa aagccgtccg 3554041 tgttttgcag aaagcccgcg ctgtcgcctg tgtgctgata ggttctttta tgggagcgca 3554101 ggccgttttt gatcgtataa atcgtgtttt tgtcctccag catcacgctg tcaccgtgaa 3554161 cctttgctga gcccagctca aggcccttca tctgaaagga agacagcgtc ccgtcatggc 3554221 tgataaacag ggcgtagctt ttcccgccgc caaatgcatc ttgatccgca gaggatgaga 3554281 aatacagcag gacttctttg tcatccagga aatcgggatt tctgagatcc tgctgactca 3554341 cggttttatg gcttttgaga ggagaaatga agacaaatag tgcgattcct gcgagaatca 3554401 gcatggcgat ggtaatcatc cactttttca tagccttctc cttagtaaat ggtcataatg 3554461 gttgtcgtat aagaagaact agtgatgtcg cgcggataca cgcctaagcc tccgttgctg 3554521 tctatatcaa tccctgcttt cagcaaaaag gcagaccata ggagctttga acagtttttg 3554581 gcgccgtcat ggccggtatt tctgttattg acgaagttaa atgagtatgg gtcgccgact 3554641 tttgataccg cccagtcggc agcagctgtt ttttgagatg aggatacgct gacggtttgc 3554701 acaatggagt tgtcttccac gtctctggca ttatacgcga tctgcctgac gccgtcgctc 3554761 gggacagatt caacaatttt gtcagcggcg gagtacatgc cgacatggcc gtgattgtag 3554821 taggctgtgt aggagttcgt gtaatagata ttgcctttcg cgcttgtcgg gagttttttc 3554881 gtgccggacg agccgcccat gatagacatg ccgctttcct tggcgagccg gtccccctct 3554941 gctttatcag ccgtgatctc cttatagaac tgttttagga taacgtcctg ctttacgtgc 3555001 tgctgtttgg caatctggct ggcagatttc atgatttctt ccggtgtcgt gcctggctgc 3555061 agtgcggcga tttcttcagc ataatttgtg gtctttacgg ctttggcggg agtaacaaac 3555121 aggccgccgc acattgtgag cgctaccaaa aacatcgaca ctcgtttctt caacttcatt 3555181 acatctcctc ttttcttgtg agtgtaggaa aggtaatttc ctcacccaca ttatattagg 3555241 aaaataagga aagtaactag gttatttaca gaatttttag aaatcgttta cagaaaaagg 3555301 cctttatcag gcccttttcg ttaaagcttc ttgctcatca ctacgtctgt ttcttgaaat 3555361 ccggtttgct catatagctt tcgagccgtc tgattatggg caaagacatg aagggacagc 3555421 ttgcggattc ccatactgcg tgccgcttga tctaatgccg ccaatgcttg ctttgcgtag 3555481 ccctttcccc gatacggttc atataacccg aaatcataaa taaacgcttc ctgctgcgga 3555541 tgctccggtt cagcatgtat ccagagccag ccaacgatat ccttttcatt cagcttgagg 3555601 ctccacaaat ggtgatgggg tgtttcgagc cctctcggaa gcagatcagt aaacacctgc 3555661 ttagacaaaa gctgggcatc ttcaggcagc catgttcccg cttttacctt ttcttccgcg 3555721 taatgctttg ttgtgtacgt gagataagac cgaaattctt ctgtctgcat aggggttagc 3555781 ataattgtca tatcatctct ccttcatata ttgactagag gattttacat aaaatagaaa 3555841 gaggtgttac tatcagaata agcaactgag attgataagt cactagagaa aggagtttca 3555901 catgaataag atcgcacccg cagaaatcgc tagcatgctc aacgattggt accttgccat 3555961 caagaaacat gaagttgaag aatcctcccg tttatttgaa gaagtgaagc ctttattgga 3556021 tgacatggaa gaggatcagg aggtgcttgc ctacttctcc ttattggaac tgcgccacaa 3556081 ggttttgctt cacgaggcga gaggacaggg ctttcagcat gaggagcctt ctcatatgaa 3556141 tgctacgtct gacatgctga aatattactt ttttctgttt gaaggcatgt atgaggccta 3556201 taaaaataat tatgacattg ccattgggct gtataaagat gcagagcagt atctcgacaa 3556261 cattcccgat ccgattgaaa aagccgaatt tcacctgaag gtcggtaagc tctattataa 3556321 gctgggacaa aatattgtgt ccctcaatca tacacggcaa gcagtcaaaa cattcagaga 3556381 agagacagat tataaaaaga agctggcttc agccctgatt accatgtcag gcaattttac 3556441 agagatgagc cagtttgaag aagctgaggc ttatttggac gaagcaattc ggatcacgag 3556501 tgaattagag gatcattttt ttgaagccca gcttttgcat aacttcggcc ttctacatgc 3556561 gcaaagcggc aaatcagaag aagcggtttc gaaattagag gaggctctac agaacgatga 3556621 gtatgcccgc tccgcctatt attatcattc tgcctacttg ctgatacgag agctgtttaa 3556681 gatcaaaaag aaagaacagg ccttatctta ttaccaagac gtgaaggaaa aattgactgc 3556741 tgagccgaat agaatatgtg aggcaaaaat agacatttta tatgccattt atgcagaagg 3556801 gggtcatgcg gaaacgtttc acttatgcaa acaacatatg gatgacttgt tgtccgagaa 3556861 agagtatgac agtgtaagag aactttccat tttggctggc gaacggtata gggaacttga 3556921 gctttacaaa gaagctgccc acttttttta tgaagcatta cagattgaag aactgattaa 3556981 acgaacggag gttatataaa tgaaaagatt tctgattggc gcaggcgtcg cagcggtgat 3557041 tttatcaggt tggtttattg cggaccatca aacccactca caggaaatga aagtcgctga 3557101 gaaaatgatt ggataaatga aaaacccccg cgggatgcgg gggttcaatt taacgaaaga 3557161 atcctaaaac ggtttgtagt tttaggattc tttcatcttt tcagcgtgat tgaaaaccct 3557221 tgaagtctag gaagaacgag cattggagcg cagcgaatgt ttggaattcg tgagcaccga 3557281 agcgcaggcc tgacaacgaa tgcgagggtt tgtcgacacg ctgaaacccc cgcgggtgcg 3557341 ggggttttct tattacagca gcttcttccc taacagggat tctacgagct ctactgctgt 3557401 tttgcccgtt ttgtttttgt gatcaaggat cgggttaacc tcaacgaatt cggctgaggt 3557461 aatgatgcct gcgtcataca gcatttccat agccaaatgg ctctcccggt agctgatgcc 3557521 gccgacgaca ggggttccga cacccggtgc gtcgttcgga tcaagtccgt ccagatcaag 3557581 gctcagatgg acgccatcac atgctgataa ataatcaagg gtttcttcaa tgacctttgt 3557641 catgccaaga cgatcgattt cgtgcattgt gtacaccttc atgccgcttt ccttaatgta 3557701 cttgcgctcc ccttcatcaa gtgaccgggc gccaatgatg acgacgtttt ccggtttgat 3557761 tttaggcgcg tagccttcaa ggttaaccag tgactcgtgg ccaatgccta ggctgaccgc 3557821 gagcggcatg ccgtgaatat tgcccgatgg tgaagtttca agtgtattca aatcgccgtg 3557881 cgcgtcatac cagatgacgc cgagattatc gtaatgcttc gctgtgcctg caagcgtgcc 3557941 gatcgcaata ctgtggtcac cgcccaggac aagcgggaat tttttctctt caatgacttt 3558001 gttgaccttt tgcgcgagtt tttcatttcc cgccaaaacg gaattcaggt ttttcagttc 3558061 ctcgtcattt ttgatttttt cgcgattgat cggaatgtca ccgagatctt caaccgtata 3558121 ccccatgtct gacagcctct cgatcagatg agcgtaccgg atggcactcg ggcccatatc 3558181 cactccgcgt cgtgcttgtc ctaaatccat tggcattcca ataaccgaaa tcgttttatc 3558241 catctgtgat tccacctcaa catttaagat aatgtcctat gcgggttata acaaagatga 3558301 cttgcggaca acgtttttaa agctctagct gacgatttgc ctgctggcgt tttttaatga 3558361 cgacatgata aatgatgtag caaatgatca taaacggtac gccgcaatac agcgcgatac 3558421 gctgctccgg atcaaatgca agactgatga gcacgaccgt atttaacgtt aggccgatca 3558481 gcggaagcac cgggtacagc ggtgttttaa atttcaaatc ttctatcttc ccgccctcac 3558541 ggatatattt gcgtctgaac atgatttggg aaagcgagat cgtaatccag ccgacctgcg 3558601 cgctcatgcc cgccaaagat aacagtacca tatatacggt ttcagcctgc gcaaactttg 3558661 tcagaagtga taggcaggcc acagccatcg ttacgattaa cgagtacatc ggtacaccgc 3558721 gctgatttgt tttgccaagc gctttgaagg cttgtccttc attcgccatc gcgtacagaa 3558781 tacgtgttga tgcgtataaa cctgagttcg caacagataa cagtgcgatt aaaataacaa 3558841 agttcatgat atcagctgca tatgggattc cgatttgctc aaatacggca acaaatggac 3558901 tttccacgac acccgcctgt ttccacggaa tcatgccggc aatgacaatg attgaaagca 3558961 caaagaacac aagcgttctc catactgtct gtttgatgga ccgcggaatc gttttttcag 3559021 ggtcttcact ttctccggct gcaaccccga tcagctcagt cccctgaaac gcaaagttca 3559081 cagtaatcat cgtaatcagc attgccttta tgccgttcgg aaataacccg tcttcataaa 3559141 aatgtgtcaa aaacggcgcc tgctctccgc ccttcagatc aatcaggcca aacatggcag 3559201 ctccgccgag aataataaat aaaaggataa tcaaaatttt aatgcctgag aaccagaatt 3559261 cagattccgc aaaggctttt gtggtgatcg catttaaaat aaacatcagt gccgcaaaga 3559321 ccagacacca gatccacacg tctatatgcg gaaaccagcg ttgcatcagc tgccccgctg 3559381 ataaaaattc aatggcgcat gtaaccgccc agccgagcca gtacagccag ccgaacgcaa 3559441 acccgaaggc cgggctgata aatttcgtgg cataggtctg gaaggacccc gacacaggaa 3559501 aggcgactgc cagctctcct aagcagagca tggtcaaaaa catgataaag ccgcccacta 3559561 aataggacag aaccgcgccg agcggtcccg cttggttaat ggtaaacccg gttccaagga 3559621 agaaaccggt tccgatcact ccgcccaatg aaatcatgaa caaatggcgt gatttcattg 3559681 tccgctggag ctgatttccg ttatcttggt ttgtattcac attctgcacc ccttcagcaa 3559741 cttgtattgg atctaagctg gaacatctgc atggtgctat cccagtttgc tgtccaaaga 3559801 gtctctatct atttaatata aaattcactt cttctcataa agatacatta tactaaaata 3559861 ctgtagctga gcaaataggg agtgctgatt tttctgttgt aaatttatac aaacgaagtg 3559921 aatatcccgc catggtgcgg atttatgcgt ttcgcagcac gtgcttaatt ttctctatcg 3559981 cccaatccaa gtcctctttg gaaatgatta atggcggtgc aaaacgaatg actgtatcat 3560041 gcgtttcctt gcataaaagt ccctcttcct tcaaacgctc acaatacgga cgtgccgctt 3560101 cagtcaattc cacaccgata aacagccctc tgccgcggac ttctttaatg acagggctgt 3560161 caatactctc aagctcgctt ttaaagtatt caccaagttc aagagaacga tccgccagct 3560221 tttcatcctc cagcacttct aatgaagcga tagacactgc acatgcaagc gggtttccac 3560281 caaatgttga gccgtgtgag ccagggttaa acacgcctag gatctcgcgg tccgccgcaa 3560341 tgcaagagat cgggaacaca ccgccgccaa gcgctttgcc caagatatac atatccggaa 3560401 caatgccgtc ccagtcacag gcaaacgtct tgcctgtacg tccgagaccc gtctgaattt 3560461 catccgcaat aaacaagaca ttctcttcct tacaaatcgc cgccgcttcc tgtaaaaatc 3560521 cttcaggcgg aatcacaatg cccgcttcgc cttgaatcgg ttcaaacaag aatgccgctg 3560581 tattcggcgt aatggcctgt cgaagcgctt ccacatcgcc gtaaggaatg agtttgattc 3560641 ctggaagcat cgggccgaat cctcgtttat attcctcttc agaagaaaga gataccgcca 3560701 gcatcgtgcg gccgtggaag ttcccgacac atgcgataat ttccgcttga ttgtcagcta 3560761 cgcccttcac ttcatacgcc cagcgtctcg ccgctttcac cgcggattca accgcttcgg 3560821 ctcctgtatt catcggcaga atcatctctt tgcctgtcag tttagctgtt ttttcgtaaa 3560881 acggcccaag ctgatcgtta tgaaacgcgc gtgacgtgag ggtgatttta tcagcctgat 3560941 cctttaatgc ctgaatgatt ttcgggtgtc tgtgcccctg gtttaccgca gagtaagcac 3561001 tcagcatatc catatattca ttgccttccg ggtcctttac ccaagcaccc agcgcttcag 3561061 aaataacaat cgggagcggg tgataattgt tggctccgta atgagacgtc tgatcaataa 3561121 tttctttgga tttagataaa gctgtcatat ttgaattccc ccttgttttc tgtttcaaca 3561181 tgttatcctg ctttcccttt atataaatgc aagttctgtg ccaaatcaag aattcgtgtg 3561241 ttttctacaa ttttcgagga caaggtgcaa aaacattctg atatttcgag cgaaaatttc 3561301 agcaagtgca aaattctttt gcatatcctc tccgtttttt tataaaatag aagcaatatt 3561361 aagaaaataa ttgagggagg ttcatacagt ggtcaaagac agcgaattcc tcacattggt 3561421 ttttcagagt attttagatg aaatcgatgt tggcctgcac gtggtagacg agcatggaaa 3561481 cacaatcgtt tataacaata aaatgatgca gattgaagat atggagaagc atgacgtctt 3561541 gaataaaaac ctgatggatg tgtttatgtt ttcaaagcag caggacagca cactggtaca 3561601 ggctcttcag gaaggcaaga cgattaaaaa cgtcaaacag agctatttca ataataaagg 3561661 ccaggaaatt acgacgatca atcatacata tcccatcgtc caagacggca aaatcagggg 3561721 cgccgttgaa attgccaagg atgtgacaaa gctggaacgg ctgatcaggg agaatatgaa 3561781 caaaaaaggc agcacaacct atacgtttga cagtattctc ggcaccagtc cggccattca 3561841 agacgtcatc gaaaacgcca agcgggcaac ccgtacgtca tcatctgtcc ttctagcagg 3561901 cgaaaccggc acgggaaaag aactgttcgc gcaaagtatc cataatggaa gcgatcgttc 3561961 tggcggcccg tttatttcgc aaaactgcgc ggcactgcca gacagccttg tggaaagcat 3562021 tttgtttggg acgaaaaaag gcgcgtttac cggcgctgtc gaccagcccg gcctgtttga 3562081 acaagcccac ggcggcacac tgctgttaga tgaaatcaac tcgctgaatc tcagccttca 3562141 ggcgaagctg ctgcgcgccc ttcaagaacg gaaaatcagg cgcatcggtt caacaaagga 3562201 tacaccgatt gacgtacgta ttattgccac gatgaatgaa gacccaattg atgcaattgc 3562261 aggcgaacga atgcggaagg acttgtatta caggctgagt gtcgtcacac tgatcatccc 3562321 gccgcttcgg gaacgaaaag aagacatttt gcttctcgcg tcggagttca tccagaaaaa 3562381 caaccatctg ttccaaatga atgttgaaca catcagcgat gacgtgaagc aatttttcct 3562441 ttcttatgac tggccgggaa atattcgcga gcttgagcat atgatcgaag gcgcaatgaa 3562501 tttcatgacg gacgagcaaa cgattacggc ttcccatctg ccctatcaat accgcatgaa 3562561 aatcaagccg gctgacatcc cagagccgga aacaccaaga caccagccag ccgcggactt 3562621 aaaagaaaaa atggaaagct tcgaaaaata tgtgatagag aacgtgttaa gaaaacacgg 3562681 ccataacatc tcgaaagctg ctcaggagct tggcatcagc agacaaagcc tccaatatcg 3562741 gctgaagaaa ttttctcact cgtctaacga ataatccgga gcaggaagcc tgatcagaaa 3562801 aacagtgcct ctgccgattt cacttttcac ttcaatcgtc ccattgtgat tgtcgataat 3562861 cgatttcgtt atggcaaggc ctaatcccga acctccatat ttccgggagc gggatgggtc 3562921 tgccttgtaa aaccggtcaa acactaaaaa acgtcacttc ttatgcattg aagaaagaaa 3562981 atggcaccta tgtgtatcac agccagcaac cacacggtac aaaccattaa agtccatgca 3563041 aataacggaa gtatttgcag ctaactgcca tttgctgttt cacgtgtaac atccatcttg 3563101 tatttttctt catattcgat atatcctttt tcaactgaac gggcgtgacc cctgttcagt 3563161 tttttttgca tatcaaaaca gcctggcaac gatgccagac tgcttttatt aactgcctaa 3563221 ttggtctgcg gaggacagct tgatatcaac agatttttct tttccgccgc gataaaactt 3563281 caccttcacc cggtcaccga cttttttctg ataaagccgt tttcgcaggt caacaatatc 3563341 atttactttg tatccgtcaa attccgtgat gacatccagt tccttcagcc ccgcttttcc 3563401 ggcaggtgaa aaggcgtcta cacccatcac aaccgctcca ttggtgacgt tcttaggaag 3563461 ctttaatgtt tcatcccaat gatagcttgc gatgtcactt agcgatttca tctcaatgcc 3563521 aaggaacggg cgtttgacct ttccgtatct ctctaaatcc tctatcacag ggatcacgag 3563581 cttagacgga atggacaggc caatcccttc aaccgctgac tcggcaattt tcattgaatt 3563641 gatgccaatg accttcccat ccatatttaa caaagcgccg ccgctgttcc cagggttaat 3563701 ggccgcatct gtttgcagga cttcagcgtt ccagtcaggc tgtccatcac cgtttgaatc 3563761 tactgggatc gccctctccg tacccgagat gacgccttgt gtgacagagc ctgcaaactc 3563821 aaggcctaac gggttcccga tcgcaataac cggctcccca gacttcactt tatctgaatt 3563881 tccgaaatca gcgactgctt taatcttatc gcttttcacc cgtaaaacgg caaggtccat 3563941 cagctggtcg ctgccgacaa gatcagctga tacacgtgag ccgtctttca agctgatttc 3564001 aatttgggaa gcgccttcga tgacatgatg gttggtcacg acataagcgg aatggtcatt 3564061 tttcttatag atgacgccag agccgctccc agcctcgccg ctctctcccc aaatatctga 3564121 tttttggatg ttcacaacac cgacaacggc gggcgacata ttgctgacaa tcttggtgac 3564181 ggcattgttg acactgacat tcaccgtcct gattgattcc cggccattgt tgttttgctg 3564241 ctgatctaag gcgcctgtat ccagcccttc atttgaaagg tacggcatga taaacgccat 3564301 taatacggca ccgacaatca cgccaatcag actcgaaaga aaatatcctt ttttgcttct 3564361 ctttggctgt tcaggagtag tatgttcttc ctcacgttcg taatccacca tattccatcc 3564421 tttccaagaa cgttaatatg gttatattgt gggttagaaa ctcctagaat agtcatgatt 3564481 tacatagaaa aattatacag cgcaaagcgg agtggccttc ttcggatcgg tgtcgtataa 3564541 gtcaaatgtc tcacccgtca caaatccttt agaagccaat gtctgctgca cagacattct 3564601 tgccagctcc ttcatgttgt tgtcctggct caaatgcgcc aggtaaatac gagacgtctc 3564661 atcgccaatg acatccgtca tcgccaaggc agcatcttca tttgacacgt gcccgacgtc 3564721 acttaaaatc cgccgcttaa tgctccatgg gtatcttccc atttgcagca taccgacatc 3564781 gtgattgctt tcaaacacaa atacattcgc tgaacggata atgcctttca tccggtcgct 3564841 gacatatccc gtatctgtca ttaacgcgag ctttcggccg ctataatgga atacataaaa 3564901 catcggttcc gccgcatcgt gggaaacgcc aaacgattca acatcaagtc cgccgaacga 3564961 cttcaccgtc tccattggaa atacaaactt ttgatcggtg tcaattttgc cgatttgatt 3565021 ctccatcgct ttccaagtct tctcattcgc atagatcgga agcttgtact ttctggcgac 3565081 gacaccaagg cccttaatat ggtcactatg ctcatgcgtc acaaaaatgc cgtctacatc 3565141 atccagctta cgcccgatct gcgccatcag cccatccatg gcttttccgc tcaaaccggc 3565201 gtccactaaa aatgcgtgat cctctgtttc gaggtaaaac gcatttcccg tactcccgct 3565261 cgcaagtacg ctaaattgca agctcatgtt tgtctcactc cattattttc attgatctgt 3565321 atctaaaatc gtactctcca aagcattcac agtaaaatac tcttgtactg tctttttctc 3565381 accgttcact tttttctcgt actcgaccgt aattctccat accggcgcca gcacctgcgt 3565441 acttgtcagc ggatattgtg ctacatagcc gaatttacag ctcttcacag tgctgtattc 3565501 ttttaattga ttttgatagt acaatagctc aaccgcatcc atttcagtaa ttaagctttc 3565561 tttctggatt tgcttgaagg tctcaagcgt agtctggtcg tatgacacaa cctcgttttt 3565621 accgtttaag tgcagcacca cttgcccgat catattagag ggattgtcgg tcttttggta 3565681 aatataatga ccttcgtacg tttggaagaa aataatttct ttcttcgatt tatcaacctt 3565741 ccaaagctta tatttttcgc catcttgaat tttcgaagaa acaagtgcct gagcatcgtc 3565801 ctcgatatcc ttctttgata gtgcgattgg atttgcaaac ttcattttca ggctcgttac 3565861 tttatgatca tcactaggca tgtccatcaa aggcttttga tccttcagcg cctcaatttc 3565921 ctccttggag aaagactttt gatttgccgt gatccgatag ccttctgttg cttccttatt 3565981 caagccttca tacgtgatat gatcggcctt catgtcatgc tcgacatcat ttttaatgac 3566041 ttcatattct ttgccggtag cctgccattt ttgaaaaaac tgatagccta agaaaatatc 3566101 taaaatgagg aaggcaacga tgaagattga ttttgtctta ttccactcca ctgttagccc 3566161 cctccttcct caataaatcc tttgtaatcg gcacaatttt tccatttact ttcatcgccc 3566221 aaaccggttc cagttcaacg agaggatcat cgttggttga tgttgatacc aattgataag 3566281 caaggaagat ctgatcaatt ttgtccgtat cataagcggt ttgtttcgaa agcagcatct 3566341 tcacttcgct gccgcccatg agctctgttt cacttgtttt aatcggattc gttccgagac 3566401 tgtaattcgg ccgcttatag ctgagaatat catcattcgc ccattgcacc gtaatcgccg 3566461 atgtcgcccc gaaaggtttg gcggtgctgt taatgaccgg gatctgatcc ataaaaatat 3566521 agaagctcaa ctgctggctg tcattgatat tgaaaaattg atagtgatcc gtccagcttc 3566581 cggtatcctc aaggtatttt tggctctttt tgattaattc acctgtttga taggatgtgc 3566641 tctgcaccaa attgcgctgc tgaaattgca cctgtctctg gcttagattc acatctaacc 3566701 ggctgatccc atctgtcagc acatttctgt tggtgtaatt cgaatcttct cttacaatgc 3566761 tcggatcact aaacaaagcc tgcttaaagg tatttgtttt aatcgattct gtgacaaatt 3566821 cttttttgtc catcgtaagc ggtttgttcg gcagcaagaa ctctttcttt gagccaatgg 3566881 agaacaaact gaacgccggc atatttgatt gcctgttttt caagtcgttc ataatgttcc 3566941 ggtagtttgc tgattcaacc gtcacttcaa gaatgagctg cttgctgtat gacaccaaat 3567001 agattttctt gttcgctttt gtttcattga acgggatcag aatatggtca aacgaactgt 3567061 attcaaacga ctgattagac catttaaaca gcgtttggaa aatatcaatc gggatcgtat 3567121 cgctgaattg caagtcaagc ttggcttcag aaccgcctat tccataaaac cagcttttga 3567181 atccagcctt gtcatactga tccgaaatat ctttaattcc tttcacatcc caatgcggca 3567241 agtcagacca aatttcttca tagagggcat tgtcatccac tttgtaatga gcgccgtcat 3567301 catggataaa catgtccctt ggccttaccg tttcagacag cttttgggtg gttttttcga 3567361 ttttatgttt cacacgaaca gtagactctg ttgaggatga gccttcagaa aagtttggct 3567421 ggaacgtcca tatcccccat gtaaaaacaa gactgatgac gacgagtacc gtaagtaata 3567481 tcgtttttat attttcacgc ttcatcccaa tcatcctctt gttcctcttt atatggaaga 3567541 gtaaatgtaa tcgtcgtgcc ttttccttct atgctgtccg cccaaatatc tccaccgtgc 3567601 gcctgtacca tttccttggc aatcgccaat cccagaccgg tgccgccaag ctttctcgtt 3567661 ctcgctttat ccaccctgta gaagcggtca aagacttttt cgacatcttt tttcggaatg 3567721 ccgatccctt catccttcac gctgatatag agaagttctt cctcttcatt gacatcaatc 3567781 gagaacgtga catgtccgcc ttccggtgaa tattttaaag cgttagaaat aatattatcg 3567841 agcacctgcg ttattttatc ctggtcaatc tcgacataca gatctctgtc cggcagattg 3567901 cggataaact ccacatgctg ctcttttgtc atttcaaaac ggtcaataat aagtgacata 3567961 aaccggacaa tctgaatcca ttcccggtta aattgataat ctttactgtc aaatttcgac 3568021 agctgaagca gatcattgac aagccggatc atacgctctg tttcattttg cgtcaccatt 3568081 aagaagcgcg gagcaatgtc tttattttcc cacgcgcctt cagctaacgc ttctaaatag 3568141 ctgcgcattg tcgtaagcgg cgtccgcagc tcatgtgata cattcgcaac gaattctctg 3568201 cgttcctgat ccattttctc ttgttcggtt acatcgtaaa tgacagcgat taaaccatca 3568261 attttgccgt gttccctttg aatcacagag aaattcacgc gaagcaccgt taattcatca 3568321 tcgcgctcaa tttcaagcag catagaatcc tgctgttcca ctaaatcttc aaaagtataa 3568381 ttctcttgaa gccccagcaa actcgtaatc ggcatttcta aggctgtttc acgtgaaacg 3568441 ttcaacagtt ccagcgccgg gctgtttaag agaataatcg ctccgtttcg gtttgtggcg 3568501 ataacgccgt ctgtcatata agcaatgaca gaggctagct ttctgcgttc tccttcagtc 3568561 atcgcctggg catcttcaag ctctctcgtt aagtggttaa acgttgtggc cagctgccca 3568621 atttcatcat gtccatactt tttaaccttc ctcgagaaat tccctttcgc aagctccatc 3568681 gcctgctttc gcatatctga aagcgggtgg gtaatggttc ttgccagaaa aataccgaga 3568741 agagccgtca aaacaagtgc caaacctgtg ccggacgcca gtatcgtgtt gatcgtcttc 3568801 atttgattaa agacatcttc catactcgcg acaacgtaga tcgcgcccac aacctcttgg 3568861 ttttcagtca tgacgggctt cgcggaaata agaactctga ttttgctttt cgggtcataa 3568921 tattttctta aatacgactg tttggtagaa aagattcttt tgaaaatcag atcggtcgtt 3568981 tgtttcccag ccacttcctc accgtacggc tttgaagaac cgaccacttc atagctttta 3569041 tctacaaagc taatttcccg aacctcatca cttttcgtga agtcattcaa aatacggctg 3569101 acgtcatcct ttatgacggt actgtcgtta tcgctcttat attcttgttc gatataataa 3569161 gaaaggttgt cgattcgctg attcagcgat tgttcataag agctgatcag cgacttctct 3569221 acctgattga caaaatacac accaatgatt tgcatggcaa tgataatcaa aagcacataa 3569281 atcaaggtaa tcttaaattg gatcgaccga aaaaaaccaa ccttattcat atgggcatta 3569341 gtcctgttct gggtttctca agtaataacc tacaccacgg cgtgtgacga tccaatttgg 3569401 atggctcggg ttgtcctcga ttttttcacg aagccggcgg actgttacgt caaccgttct 3569461 gacatcgccg aagtaatcat agccccaaac ggtttgaagc aaatgttcac gggtcatcac 3569521 ttgtccgata tgttttgcta aataatgaag caattcgaac tcacgatgag tcaattcgat 3569581 tgtttcgtct cgttttgata caacgtacgc gtcagggaag atgacgagag agccgatatg 3569641 aatctcgtta gaggaaggct cttcctccgc aggcgctgtt gtcagctggc ggcgcaggtt 3569701 cgcttttaca cgcgccaaga gctcgcgtgt gctgaatggt tttgtgacat agtcatcagc 3569761 accgatttca agcccgataa ccttgtcaat ttctgaatcc ttagccgtca gcataatgat 3569821 tggcatatcg tatttctttc tgacttcgcg gcatacttca acgccgtctt tatttgggag 3569881 cataatatct aaaagaatta aatcaggctg aagctcttct accatttcaa cggcttcgtt 3569941 tccgtcgtgg gcacagtgca cttcatagcc ttcttttctt aagttaaatt ccaatatatc 3570001 tgcaatcggt ttttcatcat ctactacaag gatcttttta tccatcattt tgattttcct 3570061 cctgccgaat gacttcattt catctatata acattcgttt catcacttat ggcccatgta 3570121 aagaatgggt ccttgtctat tataacggtt taaggtcaaa agataaaaaa aataaaggtt 3570181 tagaaaaaaa acacatgttt cacctttatc gccagttgtt tatctattgt catgctggtc 3570241 aacttttttt aaaaaagata actttattga aacctcccct caccggagtg cgtctttatc 3570301 aatgacgtct tcttctttga accggccgca gggccggttc tccctttttc ttctattata 3570361 acactcctca tgtttgcctt tttcctaaaa gaaaaaacgc acctacgatt gcagatgcgt 3570421 ttggtaagtg gctcgggacg gaatcgaacc gccgacacac ggattttcag tccgttgctc 3570481 taccaactga gctaccgagc caaatgtttt atttttctct actaagtaaa gtaaaatggc 3570541 ggtccggacg ggactcgaac ccgcgacctc ctgcgtgaca ggcaggcatt ctaaccaact 3570601 gaactaccgg accttacagt aattgcccgg agagctgtcg tgtcagctct cacagacaaa 3570661 taaggaattt agcaataacg ctaaagtaaa tcaatgaccc gtacgggatt cgaacccgtg 3570721 ttaccgccgt gaaagggcgg tgtcttaacc gcttgaccaa cgggccttca cgaaatggtg 3570781 agccatgaag gactcgaacc ttcgaccctc tgattaaaag tcagatgctc taccaactga 3570841 gctaatggct cttaaagatg tcggaatttc tatagagcaa acgacttaaa tctagttctc 3570901 atcttgtact ctattgaagc agtttccgta acaacgagat ttataatatc acgaacaaat 3570961 agaagtggca ataacttttt tggttttttt tcatattttt ttctcagacc aacttatatg 3571021 cggctttcaa acaaaaaaca agccccttaa ataggggctt gcagacatat tctatttagt 3571081 tcgcacggta cacactgcga aggacatttg tttgtgagcg gtctggaccg acagagaaaa 3571141 tagaaagcgg aatgcctgtc agctgagaca cacgctcaag ataatggcgc gcattttccg 3571201 gaagctcgct caagctcttc gcacctgtaa tatcctcagt ccagcccggc atttcttcat 3571261 ataccggctc acattcagca agtgccttaa gacttgctgg gaattcttca atgatttcgc 3571321 ctttgtagcg gtacgccaca cagattttca acgtttcaat tcctgctagg acgtcaattg 3571381 agttcagaga aagatctgta attccgctca cacggcgggc gtggcggaca acaacgctgt 3571441 caaaccagcc gacacggcgc gggcggcctg ttgttgttcc atattcgcgt ccgacttcac 3571501 ggatttgatc gccgatttca tctttcagct cagtcggaaa aggaccgtcg ccgacacgag 3571561 tcgtatatgc ttttgataca ccgacaacgt gcttgatttt ggtcgggccg acaccagaac 3571621 cgatcgtgac accgccggca accgggttag atgacgtaac aaacgggtat gttccttggt 3571681 cgatatcgag cataacccct tgtgcgcctt caaataatac acggcgccct tcatcaagag 3571741 catcgtttaa gacaacagat gtatcgcaaa catacttttt aatctgctgt ccgtactcat 3571801 aatattcgtc taagatatcc tcaagtttaa acccttctgt ctcgtacatt ttctcgagaa 3571861 gacggttttt ttcttcaaga ttgcgctcaa gcttttccgc aaacgcgtca cggtctaaca 3571921 gatccgcgat gcgaattccg atgcgggctg ctttatccat gtaagcaggg ccgattcctt 3571981 ttttcgttgt gccgatcttg ttagcccctt tacgctcttc ttccacttca tccaatttca 3572041 aatgatacgg cagaatgacg tgagctctgt tgctgattct caggttatct gtactcacgt 3572101 tgcgctcatg aagatacgca agctctgtga ctaatgcttt cggatctaca accattccgt 3572161 ttccgattac acacgtttta tccttataga aaattccaga cgggattaag tgaagcttat 3572221 atgtgattcc gtcaaacttg attgtatgcc ctgcgttatt tccgccttga taacgggcga 3572281 tcacttctgc attttctgat aggaaatctg taattttacc ttttccttca tcgccccatt 3572341 gcgtacctac tacaactact gaagacatgt ccgtgcacct ccgttaacct ttcaaaacga 3572401 ttctattcaa acaaatcaag tttatcagtg aagaaacaga aagtcaattg taaatccgaa 3572461 cattaattta ttgtaaatct atattcgttc gcttccattc gttttataag cgttttctca 3572521 ctgctttgtc ataaaaagct tgcgaaactt tcatccttta gcataagaaa gaatcacttg 3572581 cctgatatcc cttttgaatt cataaaaacg atccgccagc cgtccgggtc ctctatcgtc 3572641 acgcccccat tgctccagta cgggttctct gattcgacct cttgatagcc catgtgcttt 3572701 agctttgaag tgatcgctgc cagttcaact gcattcggca cataaaaaac aagaaggctg 3572761 tcgggatggg gaacgggggc agtgcttccc ccttcatact gggtgaattc caaatgataa 3572821 tcggcatgag gaaggccgaa catgacaccg tcatacccgt tatgctgtga aaattctcct 3572881 attcgtttca aacacagtcc ctcttcgtaa aaacgaataa tctcatcaag ctggcccgta 3572941 ggacgcgcaa ttcggatttg tgctgcttga aaagacgaaa aacgttttcc catattgtta 3573001 ccatctcctt tttgcaccat tttattaaaa cgctttcaat ttttcatccg ctgagcgaac 3573061 gtcatttctt ccatctttcg aatgaaaaaa accccaagag cagctcttgg ggcttatgcg 3573121 ccgggcggaa cgcctgcgtc atcaaaacgc cgttccaggt tgacgaattt gttgtattct 3573181 tttacgaacg caagagacac ggttcctacc gggccgttac gctgtttggc gataataatt 3573241 tcgataatat ttttattctc ggtttctttg tcatagtagt catcacgata aaggaacgcg 3573301 acaatatccg cgtcctgctc gatacttcct gattcccgga tatcagacat catcggacgt 3573361 ttatcctgac gctgctcaac acccctggaa agctgagaaa gcgcgataac agggacttgc 3573421 agctccctcg caatcgactt cagttcacgg gaaatttcag atacttcctg ctgacggttg 3573481 tcctttgaac gaccgcttcc ctgaatcaat tgcaggtaat cgatcaaaat catgcccagc 3573541 ccgctttcct gcttcaagcg gcggcacttg gcacggattt cactcactcg aatacccggt 3573601 gtatcatcga tgtaaatccc gctgttcgat aggcttccca ttgccatcgt cagcttgccc 3573661 caatcctctt cggtcaggtt acctgtacgg agattctggg cattgatatt tccctcggca 3573721 cagagcatac gcataacgag ctgctcggca cccatctcaa gactgaaaat cgctacgctc 3573781 tcatcggtct tcgtcgccac gttttgtgcg atgttcaggg caaaggctgt tttccctact 3573841 gaaggacggg cagccacaat gatcaagtcg ttgcgctgga aacccgcagt catccggtca 3573901 agctccgtaa accctgttgg aattcccgtg atatcacctt ttcgattgtg aagctgttcg 3573961 atattatcat aggtctggac aaggacgtcc ttaatatttt ggaaggcact cgtgtttttg 3574021 cgctgtgcca cttccataat cgttttttcc gcttcactga gtaaatcctc gacctcatcc 3574081 tcacgggtat acccgtcttg agcaatcgtt gtcgcagttc tgattaatcg gcgaagaatc 3574141 gatttttcct caacgatttt cgcgtaatat tctatgttag ccgctgtcgg caccgagttt 3574201 gcgatatctg tcaaatatga aataccgcct acttcttcca gcaggtctgt gttcgcaagc 3574261 tctgatgtaa ctgtcaccag atcaaccggt tcacctcggt caccgagcac cagcatcgca 3574321 ttatagattt tttggtggga cattctatag aaatcatctg gaatcaatac ttctgaagcc 3574381 agtgttaaag cagacggctg taaaaaaata gcgcctaaca cggcttgttc ggcttctata 3574441 ttttgcggag gaagccggtc attcagaagg tctgtcatgc taagcaccgt cctctcatta 3574501 aaaaatctcc aacctccatt ctaccatttc tacagaaaaa aaatagaaaa attgtctgtt 3574561 tcctgttttt ttcagttagc agattggatc gtttcggaca gtaacaaggc gggaaaaatg 3574621 caataaaaca taagggagga atgaaagatg ataaagaaat atgcgattac acctaatgtt 3574681 gatgcggacg gctggtttat tgaggtggag aatgtagcgc cgacagcttt gtatacgtct 3574741 aaagacgccg ctattgaaaa ggccaaacag gtggctaagg aaaacagtcc gtctaagctt 3574801 gtaatttatg accagtttaa aaatgtggaa gaagaacact cattttaatg aatgaaagcc 3574861 ttcgctgcag cgagggtttt ttagcggtta tcggtttatt tcatccattg gatgcctatg 3574921 tgcatcatca aatctgccgc tttttgatac agatcccact ccccgatcga agcaaatttc 3574981 cccatcagct cctgaagctt taacctcatt gctatatatt cttcgaaagt gacagctttt 3575041 tcagtgtcta tttggtgttc cttcagcatt tgttttaata aggataacgg tgcgtgcata 3575101 agaaccctcc ttacctcttt tataacggtc attttccgat tgctctattc ctttgtgaca 3575161 tcttcttaca tttcacatct gattcttgta caatggacag aagagaggag ggatcttttg 3575221 tgagaccttt gcaaatttct gccgaaactg cacaaaagct tgcagagtcc ttgaatctgc 3575281 cgcttgaaca gatcatgcat atgcctcagc atattctgct tgccaaaatg gctgaactgc 3575341 aaaaagagga caaatcatag ccttcattca catacttgct tacctgtttc gggataatat 3575401 catgtatatg ttagaaaaga ggagtaactg ctttgccaca tccacataat aaaaaaatcc 3575461 aatcattttg gctgatcacc ggcattatct ttatcgcctt taacttacgg cccgcgatca 3575521 cttcagtcgg tccggtcatc agctctatcc gggcagagct gcacatgtcc aatggggcag 3575581 ccggtttttt gaccgcactg ccgctgcttt cgtttgcagt tctttctccg cttgcaccta 3575641 agcttggaca gcgcctcggt aatgagcgaa ctttatggct aggtctcgtg atactgctga 3575701 tcggtgttct gactcgttct accggctata ctgccgcttt gtttttcgga acagcactta 3575761 tcggcgtcgg gattgcgatt ggtaacgtac ttttgccaag cttaatcaaa cataaatacc 3575821 ctgaaaagcc agggatcatg atcagcctgt atacgacatc aatgaatata ttcgcagctt 3575881 tagcatcggg tgtcagcgtt cctttagcga cccagatgaa tggcggatgg aaacaagcct 3575941 ttctcttatg gggcgggctg gctttacttg cattgctaat ctggatacct cagctgcgcc 3576001 atcgagatac ggcaaaccag acaatgaagc tgcaatccag ttccatttgg gcttccaaaa 3576061 tggcatggta tgtcaccatc tttatgggcc tgcaatcgtt tttattttac agcagcatcg 3576121 cttggtttcc tgaaattctc cgttcacacg ggattgatac ggcaacagcc ggatggatgg 3576181 tatcactcat gcaatttgcg agtctgcctt ccacttttct gacgccagtt ttagctgacc 3576241 gtgtgaaaca gcagcgcggt atcgttgcgg cgctggcctc agtttatctg atcggccttt 3576301 gcggattatt agcgggcgga agccatacat tgcttgccat ctggatgatc attatcggta 3576361 tcggacaagg ctccagcatt agtctggccc ttactttgat tggtctccgc agtgaaaatg 3576421 cccaacaggc cgctgcgctg tcaggcatgt ctcagtcatt cggctacctg ctggcagcag 3576481 tcgggccaat ctttgtcggc tatctctttg accagacgca ttcttggacg atgccgattg 3576541 tgcttctcat tgctgccctg atcgtaatgg gagcagccgg acagggagcc ggacgagatc 3576601 gatacatttt ccagtcagaa aaacaaagaa attcagcata aagcggggaa gatatctccg 3576661 cttttttctt tgaatattta tggtttattc ataagttttt catatttgtt ttttacaatg 3576721 agacaccata aagaggtgaa aaacgatgaa aaccaaacga ttcgacgcag cccttattct 3576781 tattttgcta gcagcagctt ttttgaatac gtatcacatt tggcaggatg atacagcaaa 3576841 ccagtactat ttggcggctg taaaaagcat gacgcaaagc ttccataact ttttttatgc 3576901 gtcatttgac ccttctggat ttgtgacagt agataagcct cctgtcgtgt tatggattca 3576961 aacgattttc gcactgattt tcggtgttca cacgtggagt gtcatcattc cccaggctct 3577021 tgccggagtt ggatctgtct tccttctcta cagaatggtt aagccgactt ttggagttgg 3577081 agcggcccgc attgccgcac ttgtcatggc actgacccct atcgcagtag ctgtcagccg 3577141 gacaaacaat atcgacagca tgcttgtttt taccttattg ctcggttcaa cttgtctgct 3577201 tagggcagta aaacaaggca agctggtttg gctgctgacg gcatttgccc tgattgggct 3577261 cgcctttaat atgaagatga tgcaagcgtt tatggtattg cctgcatttg tgttattcta 3577321 cctgattgca tctcgggttt ctctgaagaa aaaaatcggg tccctgcttc tgtctcttgt 3577381 ccttctgaca ggcctttcac tctcatgggc gattgcagtg gattcagcct cttcctcaag 3577441 ccggccttat gtaggaagca gccagactaa ctcagtgcta gaactggcct ttggctacaa 3577501 cggcacagag cgtctgtttg ggcaaactac gggccttgca aagggtgata tgaatgctgc 3577561 tggcggaggg aacatgcaga atcaagacaa catgcaagcg ccaaatggca acggttcatc 3577621 tttttctcag aacggtaatc aatcattcgg aaaccattca caggcgcctc agccgcctaa 3577681 cggacaaacc ggcgctctca atggaggcgg aggcacacct cccacaggtg gcaacggacc 3577741 tggaaatgga gggcctggcg gcggaggcgg aaaaagcgtg aatatgttcg gcaccggtga 3577801 tcctggaccg cttcgtctct tccaatcagc actttccggc caaatcagct ggatgcttcc 3577861 attctcattg atcggattac tgggcgcaat catcagctgg taccgtgatc gccgcggaca 3577921 tgctgctaaa atgaaagaaa cgctattctg ggcggcttgg cttgttcccg tggctggttt 3577981 cttcagcatc gcaggattct tccaccagta ttatttgatt atgctggcac cgccgattgc 3578041 cgccctttct ggtatcggat ggtatacgat gcaccgctta tacaaaaata ataaagactg 3578101 gtccagctat cttctgccgg cagccgtctt gatcacagcc gtgtttcagg tgtatattct 3578161 gagcgcttat acaagccaaa tcggcagtgt atggatgtat gtcctggggc tcttaggact 3578221 gggcatcacc cttgcacttc tgatgcttaa acgcagccat ccgttcagta agctgctgac 3578281 catcatcagc ttgtgcgttc tgcttctcac accagtttac tggtcagcaa cgccgcttct 3578341 atacggtggc aacagcgtcc ttcctgaatc cggcccgcag ctcaaaggct cagcaaacgg 3578401 cgggaacatg ttctcttcag aggtcgacag cgggctcctg tcctatctga gaaaacacaa 3578461 taccggcgaa gagtatttat ttgctacttt gacaaccgta acagctgcgc catacatcat 3578521 ttacgaaaat gaatctgtta tggcaatggg cgggtttaac ggcacggatc ccattctgac 3578581 tgtgtcggaa ctgaaaaaac tgatcaaaga aggcaaagtg aaatacttcc ttctgtcaga 3578641 aaacaactca ggcaacagcg aacttgtttc ctggattaag aaaaacggaa aagaaataac 3578701 atctgacgag tacagcggtt cctccagcag cacaaacagc gtgcagggaa tgcgaagagg 3578761 acctggcgga gaaagccagc aaactcttta tctcgtggaa taaaaaaaga ggcttggatg 3578821 aatccaagcc tcttttctat taagcttctt cttttacatg tacctttaac acagcctgca 3578881 cttcaggatg cagcttcaca ggcacgtttg tatatcctaa tgcacgaatg ccgtccggca 3578941 gttcaagctt ccgcttatct actttaatgt tatggtcttt ttggagctgt tcagtgattt 3579001 gcttgcttgt cactgaacca aataaacggc cgccctcacc tgattttgcg ctaagctcaa 3579061 cagtcagttt ttctaatgtc tctttcaagc tcttagcctg ctcaagctca gcaatggctt 3579121 cttttttctc tttctgcttt tgtccgttta acgcgctgat gtttgacgcg ttcgcttcaa 3579181 ccgcgaggcc ttttttaatt agaaagttat gcgcataacc gtctgctacg tttttgactt 3579241 cgcctttttt tccttttcct tttacatctt gtaagaaaat aaccttcatc tctgtacgcc 3579301 tccctcaaaa tactcatcta tggcgtgctt cagccgttcc agcgcttcag aaactgaaat 3579361 gccggacaac tgagtcgccg catttgttaa atgccctccg ccttccaggg cctccatgat 3579421 gatctgaaca tttacctcgc caagcgaccg agcactgata caaaccgttt gttcatcccg 3579481 tctcgccacc gcaaatgaag cctcaacctc actcatcgat agcagcgaat cggcagcctg 3579541 cgcaatcagc acttgatcga agtattcctc ttcattttca ggaagagaag caatcgcaat 3579601 gttatcttta tagaggaccg tatgctggat cagcttcgcc cgtttaatat aggaatcaac 3579661 ggtttctttc agaaacttct gcaccagcac cgtgtcggcg ccttttgccc ttaaataaga 3579721 agccgcatcg aaagtccgcg agcccgtgcg gagagaaaag ctctttgtat ccactattat 3579781 accagctaat agggctgttg cttcaatcat attgattttt aagcgcttcg gctgatattc 3579841 aagcagctct gtcaccaatt ccgctgtgga agaagcgtat ggttccatat aaacgagcag 3579901 cggatctctg ataaactcct cacctcttcg gtgatggtcg atgaccacga tatgttcaat 3579961 tttattgacc agccgttcct ccatgacgag tgacggctta tgtgtatcaa cgatcacaag 3580021 cagtgtgtca tcattggaaa tctccattgc ttcttcaggc gtaataaatc ttgaccacag 3580081 ttcttcatat tttttgattt ccccaatcaa acgctgcaca cttgatccga tttggtttgg 3580141 gtcaatcacg ataaaaccat ctttgttatt tgcctgagcc acctttaaaa tcccgatcgc 3580201 tgcgccgata gaatccatgt cggggaattt atgccccatg ataatcacat tgctgctttc 3580261 ggtgacgatt tcctttaagg cgtgagaaat cacgcgggcc cgcacccttg ttcgtttctc 3580321 cattgggttt gttttaccgc cgtaaaactt caccttgccg tttggcagct taatggctac 3580381 ctggtctccg ccgcgtccca gtgctaagtc caagctggat tgcgccaaat cgccaagttc 3580441 tttcagggaa gagactgaag ccccgacacc gacgcttaac gtcagcgcta caccgtcaaa 3580501 cgaggttttt tcccgcactt catcaagaat cgaaaacttc gaattttcga gttcagttaa 3580561 gatatgttca ttaagtacag caataaagcg ttctgaagac gtccttttca agaagatccc 3580621 gtactcctgc gcccaagcgt tcagcaaaga tgtcacctgg ctgttcatcg tgcttctcgt 3580681 ctggtcatcc aatccttgtg tcacatcatc atagttatca aggaaaatat atgccaggac 3580741 ggttctttcg ttttcatata gcttttcaat ctggatttgt tctgttacat caaagaaata 3580801 taagagacgc tcatcccgtt tgatgacaac cctaaacttg cggtcattca atgtaaccgt 3580861 ttccgattcc acctcttgtt tgataagcgg cactaccgat tcacaagtat cgtaaagtga 3580921 tctccccact aaagtgcttt cattaaaaca agaggaaaga aacggatttg cccattctat 3580981 ataatattgg tcattaaaaa gcatgattcc aatcggcatt tccatcaatg cctcttcacc 3581041 gacttttttc aacctgtagg acaacgtaga aatataagca tcaatctctt gtcgaataag 3581101 agaatcagca cgcttaataa aaaacaaaat aactgccagc agcagcactt cgacggttcc 3581161 taatatccag ttaaaataaa agctgatgag gattgtaata attgacagag caatcaatgc 3581221 atagatggga taccgaaaca gcggtttttc ataaaagctt ggcatttcta tcactcccca 3581281 ccatgtgagt aaaactcatg ttcacttcac cttattcctt atatgaaagc ccatatctaa 3581341 aacgcctaaa atgcgaatgg ccgccatgaa gaccggatgc acaaacccaa gtatgacagc 3581401 aatcacagcc gcagcctttg gatattgttt cttatggcaa tagaaaaaga taaatgataa 3581461 accttggatg aaaatcagaa acccgagtat aaactcccca tttaaagcga tagagtacag 3581521 catttggcct ttttctaaag gcaaaaatga aagcatgaca ataatcaaat acagtactac 3581581 aacactttgc ggaaacttca actctctaaa aggctttaga ttaggaatat cgggggagaa 3581641 tcgccttaag agcggcttag cgataaggta actgaggaaa gaaaaaataa ctcctaccat 3581701 cacaatagct gttggaaaaa gatattgaac gatacccaat tgttcttcca tcagttttaa 3581761 ttgcttctca aactgcccag cattgcccga ctgcttcgct acagtttcta caatatcaag 3581821 agattgccgg tattgtgtca ttgcctcatc aatgatattg atacccaaaa actgaatgct 3581881 tatcacaaaa tagaagacaa tactaagcat ataaataaga gcgcccgaaa taatggcgtg 3581941 cccgggctct ttccttttga aaaaatgtcc catggcaatg ccggcgcaag ctgacataaa 3582001 agctacaata agcccgttaa aggacccgac aataaaaaca accggaagac tgacagcgcc 3582061 catccatatc cctagcttca atccatgtct gatcgtatac aagatcattg gcagcggcag 3582121 tgcaaataac agaattgttc caatcacagg aacataaacg accagaagcg taatgatcgc 3582181 aaacagactg attaaaatag caccttccat taaagctctc gtttgtttca cttagtcacc 3582241 tcgtatcatc ctgaacatac gaatagaaaa gagcagcata aacgactgct cttttgttca 3582301 tcgctgcaac atgctttgca ccgaatgttt ttatatcatc tctaaatttt acttttatat 3582361 tttaacataa gtccaaatcg caagtaaaat gacgctaatg tttcatgtga aacatgaaaa 3582421 aggaaaagac attctttgaa aagaatgccc atcacaatta atgtttatca tccataaagc 3582481 cagaagattc cttgtttttc tttttcgttt ttctgacata cataaaaatt aagatcacca 3582541 gtaaaagggt tgttgcttgc agaacgccgc tgctaaacaa gaaaaagttc tttatcatgt 3582601 cccacattgt gtttcacctc tttgtgcatg ttctcaaccc gtatcctata taaggtgaat 3582661 ttcccttttt aaaaacttca aaacatcatg aacaacattg agcgttgggc atatgctgat 3582721 atggaatctg atcgataaag gagaattttc acatggatga acgcagaaca ttggcttggc 3582781 atgaaacatt agaaatgcac gagctggttg cttttcaatc aaacggactc attaaactga 3582841 agaaaatgat aagagaagta aaagaccctc agctcagaca gctttataac gtgtctattc 3582901 agggtgttga gcaaaatttg agagagcttc ttccgttctt tccacaggct ccgcacagag 3582961 aggatgagga agaagaacgc gcagataacc cattttacag cggtgacctg ctcggttttg 3583021 ccaaaacatc tgtccgcagc tatgccatcg caattacaga aacagcaaca cctcaattaa 3583081 gaaacgtact ggtcaaacag ctgaatgctg ccatccagct gcacgcccaa gtttatcgat 3583141 acatgtatca gcatggatat tatccgtctt acaacctttc tgaactgttg aaaaacgatg 3583201 tcagaaacgc caacagagcc atttcaatga aataaaacaa gcagcaaagg agttcccttt 3583261 gctgctattt ctgctgatcc ttcactaagc cgttcgaacg ataagattcc agcacgtctc 3583321 tgttggattc tccccattct ttcatttgca aaacaatcgg ttcaagcgtg cgcccaaatt 3583381 ccgtcagaga gtactctacc ttgggcggca cctggtgata aacctcacgg tgcacgatgc 3583441 cgtccgcttc cagctccctc agctggagag taagcattct ttgagtaata ctcgggcaga 3583501 ttcgccgaaa ctcattaaat cgtttcttgc catctatcat gtgataaaaa agaattcctt 3583561 tccactttcc gccaatgaca tctagagtga attcaactgg acagccttct ttgttcgggt 3583621 atatattctt tttttcactc attcttgacc ctccaatagt accttttttg atactacatt 3583681 acattttgca actaatctac ccagtatttt acacaccttt tctccttagc tcaaagaaaa 3583741 tgcttcttat tcacatcaat ttttaagggt ttgcatgatt acacctgcag caagacgtgt 3583801 taaactatat aaagattaca ctacttaaaa aaggatagga gctatcatgg aaaagatact 3583861 tattttcgga caccaaaacc cagatacaga tacgatttgt tctgcgattg cttatgctga 3583921 tttgaaaaac aaactcggct tcaatgctga gcctgtccgc ctcggacaag tcaacggcga 3583981 aacacaatac gcgcttgact atttcaaaca agaaagcccg cgtcttgttg aaacagctgc 3584041 aaacgaagta aacggcgtta tcctggttga ccataacgaa cgccagcaaa gcatcaaaga 3584101 cattgaagag gttcaggttt tagaggttat cgaccatcac cgcatcgcta actttgaaac 3584161 agctgagccg ctttactatc gtgctgagcc tgtaggctgt acggctacca tcttaaacaa 3584221 aatgtacaaa gagaataacg tgaaaatcga gaaagaaatt gccggcctta tgctgtctgc 3584281 gatcatttct gattccctgt tatttaaatc tccaacttgc acggaccaag acgtagcagc 3584341 agcaaaagag cttgcggaga tcgctggagt agatgctgaa gaatacggct tgaacatgtt 3584401 gaaagcaggc gctgatctaa gcaaaaaaac agtggaagag ctcatttctc ttgatgcgaa 3584461 agaatttaca ctcggcagca agaaagtcga aatcgcacaa gtaaacacag tggacattga 3584521 agatgtaaaa aaacgccaag ctgaattaga agctgtgatc tcaaaagttg tggctgagaa 3584581 gaatcttgat ctgttccttc tcgttatcac agatatctta gaaaatgatt cacttgctct 3584641 tgcaatcggt aacgaagcag cgaaagtgga aaaagcgttc aacgttacat tagaaaacaa 3584701 cacagccctc ttaaaaggcg ttgtttcccg taaaaaacaa gtcgttcctg tcttaacaga 3584761 cgcaatggct gaataagcaa aaagcatccc gcgtcgggat gctttttctt attcacccag 3584821 cttctcaatt tgtcccatca catcagtaat ttgctttgcg ttttggacca ggtctgactg 3584881 ctccaattct ttaagcgata ccttgccttc ctcggcttgt ttcaacacat cttcagcgct 3584941 tttctgcaag gtttcgttat gctcctgaat ggttcgatga atctccgctg cggcatcagg 3585001 cggcgttaat tcattaaaat cagcggcagc cttctgaatc gactcaagct gcgcttcaag 3585061 tttttctttc gcctcggtgt catttacagc tttctcagcc aattcaggcg cttcctctgc 3585121 aaatgtcttc accttctcca cataaccagc tgcttcactc gtatagttca atccgtcgtt 3585181 cacctgatca agcatgccgc atccgcctgc actcaaaagt cccactccgg caagtactgt 3585241 caaaatgatc ttcatcttca gccccctcat cgtttctttt tcattttttc ttttaagatc 3585301 ggaatcaatt tctctttcgc taacggcagc cctttcctca ccaattcacg cttcagccac 3585361 tttttcagct tagacattct gatgctcctc tccctttttg ataaaaatga aaaaactcca 3585421 ccaatttggt gaagttcctg aaacaaaaag accttcacca aatcagattt ggcaaaggtc 3585481 tcgctaacaa tgagattgcc agcaaagccg aggacacctt gtcccgtaat gacgacttta 3585541 ctgtgaaagc tactcccctt tggagtgttc atttttatta ctttcattct aaagcaccga 3585601 tctgttccag tcaaattcct gccgtttata taaaagcgcg ctgtggtatt taaaatttga 3585661 atggtttttc tatcaggaga tcatgctatg acagaggagg ttttcatcat gagtcaagag 3585721 cgcgtgaaac ggcctgggca taccagatgg tacatatctt cgttacttag cggcattatt 3585781 attcttaatt attttgaccg agtggccatc tcggtagcgg cccctgcgat acaagattcg 3585841 tttcacctta ctgcaactga actcggcatc gtgttttcca tttacaccta ttcctataca 3585901 ctgatgcagc tgcctgtcgg aagtttgctg gaccgttttg gggtcgcatg ggtcacgagg 3585961 gttggaatga caatatggag ctttttaacg atccttcttg cttttttgca aggaaaattg 3586021 ctgttgtatc tgttccggtt tctcattggg ctgacgagcg cctctgcgtt ccctgctgcc 3586081 tctaaagcaa ccgctctctg gtttcctcca agtgagcggg gattggcaaa ctcactgttc 3586141 gattcggccg ccaagttttc aaatgtaatc ggcgcgccat tggtcgcctt tcttgtcaca 3586201 acatttgact ggcgtgtcgc ttttttgacg attggatgca tcaatgtgct gtttacgatc 3586261 tttttctggc agtattatga acagcctgaa cggcacaaac gcatttctaa aagtgaacta 3586321 aactatattc aaaaacacaa tgccattaca acagagcaaa tcccttacaa aacgggcccg 3586381 cttttaaaaa agcttttcac caatcgaaaa gtatggggct taatgatcgg atttacaggg 3586441 tacgggtata cattcaacct gctgctcacc tggcttccga ctttctttaa acatacatac 3586501 ggtatggatc tcatgtcgtc cggtttattt acggcagtgc cgtggctgat ctcaaccatt 3586561 tccggaattg ccgtcggcgg ctggctcgtc gattatttta ttaagaaagg ctatcctaat 3586621 accaaggtgt accgaaccgt aatcatagtc ggaatgagct ttggcttttt ctttttagga 3586681 tccattctga cgaacaatat taccgtagcc attatttgca tttccatcgg actcgccgga 3586741 atttccgcaa ccgctccggt cggctggtcc atctccgcag aactcgcgcc gatcggttcc 3586801 gtatccatgc tgagctccat ggtgaatctc gcaaacaacc tgttcggagg cattattgct 3586861 gcgtcactga cagggtattt gtttgatgtg acaggctcct ttaccctcag ctttctggta 3586921 gctggttttg tgctgttgct gggattggtt ttttatgtgt ttgtattagg ggatgtaaaa 3586981 cgaattaaac tatagaacat gaaaaagaga gctgccagtt ggcagctctc cctttacatc 3587041 aaagaatcgg cccgtcccca tttaccttct cctcgtcctg ttcctctata tcaagccccg 3587101 aagctagcat ttcctgctct atctgttcga gcacctgctc gttttttcct tgaagaccac 3587161 cttcataatg aaaagcatcc tgtgtgccgt tttcctctat tgtcgctaaa atatcgtgga 3587221 tatcattatg gtctcctgaa atggagccga atccctggtt ttgtttttta taattcacaa 3587281 aaccgctggg gaggttgttt ccgaggttta cacatgatgc gctccgagta gtaattcatc 3587341 agtgtatcaa aatcttcatt ttggattgcc acatcacatg cagagatgat gtctttcaat 3587401 tgctgttcca aatgaattcc cctaatcatc atgattggat atattataca atgtttgaca 3587461 cgtagggatc cttttcattt ttgtttttac ggtttcgctg gtccatttcc gcagagctgg 3587521 cgccgatcgg ttccgtatcc atgctgagct ccatggtaaa tctggcaaac aacctgttcg 3587581 aaggcattat tgcggcttca ttgacggggt attttgtttg atgtgacaag gctcctttac 3587641 gctcagcttt ctggtagcca gttttgttct gctgcttgga ttggtttttt acgtgtttgt 3587701 cttaggggat gtaaaacgaa ttaagcggga ataaagagtg cttgtagaga aaacgttgtt 3587761 ctttctacaa gctttttagt tttgtgctgt ttttcaagat attcagctgt cataaaaaga 3587821 aaatgagctc ccacataccg gctaggtatg tggcgttctt cttcatgttc tggcatgcag 3587881 ctgtgaggag gatttgtttg ctcaccccct gaacctgcga tagctaagcc cgtgcagttg 3587941 ttttgaacct acaaagcttc gttctatttt ttcttttctt tttttagaga tttcctgaaa 3588001 tagaaaagca atcttttcta accttttctt tatggttttg ccatacatac cgagtaacga 3588061 ctttctggcg tttcgttgat tttgtgtaat attctcaaac atatttcagg atttgattta 3588121 tatgaccgat agtctttgcg atcaattgtt gagtacgtaa gtgtatgctg attcaacaaa 3588181 tgtatctgta ttgttcactt tataatgaaa tttccatttt ggaagcaaac ccctgactgg 3588241 gtgataacgt ctatgtgcga tggcaccaaa aacttggagg tcaaatagtc ctttagagat 3588301 gagagttgtt aagtagccgg aatctagagc gacggcttct acttgaaaat caaatcatgc 3588361 aatttagtga tccaatcggt caaggtaggg cttggaacag aatcatggac ttttctggag 3588421 ttgcaaacta ttaatcgtcc tcattaaatt tataataaaa atattctcaa ttgagcaaat 3588481 cgcccaccct ttttccttta taacataaaa tccaatacta tcaataaaat tctttacagg 3588541 ttattacagt taagatataa tatagttaat cttttacgta aaaggaggtt tttattactt 3588601 gtgttgaagt tttaaatagg agtaactcca tctccccatt acggtcttca tttaatttca 3588661 tcctgagttt tatttagtta gatataaaaa cgaaaatttc acattatttt taactaaccg 3588721 atagtataaa atatatattg aaaggattgt aaaattatga ataaattcct gaagagcaat 3588781 ttccgtttcc ttcttgcggc tgctttaggc atatcattac ttgctagtag taattttata 3588841 aaagccagca atgataacta taaattccat ttacttgtac cttatggcta tggtaatgcc 3588901 tattcaaatg atgcatttag acagaccact catacagata atccttggaa agtaaattta 3588961 cagaaatcgg cagaaggtaa aggtacaatc atgacatttt ggttgattaa cacagggaat 3589021 agtaaaattc caaaagcttc taaaatacat aacgtaaaac aaggaagcgg agctcattat 3589081 tatcatgcaa atagccaggg aagccataca tatgtagcct tagcagttga aaacaacaat 3589141 tacagtgcaa gttcttatgg tatagatggt gtatgggatg aagaaacttg gtaaacaaga 3589201 accttctaaa aacgttggca ccttttagcc acgcgaaaaa atttagaatg ataatctttt 3589261 tataagatta tcatttttat ttattctatt aagaattgag tgagaacatg gaaagtcata 3589321 tttatcgcat tatcaaaaat aaattaacta taataatatt tactataatc atattaattc 3589381 cttgtgttga tatatcacta ttgttaatga ctaacacaga ataccatcct gcatatgcgt 3589441 ttttcctttc tggcacttcc gtagggcatg cttcacaaat gatcctatta tggtttcttc 3589501 cgctttattt tttgttacta tgtgctgacg attctataca agattataaa acaggatatc 3589561 attacattct tataagcaaa gttggcagaa aaaaatattg tttggaaaaa atatttacct 3589621 cttttatcat ttcatttttg acaatgtttt tgtcactaat attaaacttt ttattggttc 3589681 aggttttctt ttttaaaggt acatttaaaa atgacttaga ccaaattaaa ttccctgata 3589741 acagccttta tacttttagt atggcccatc cttatatagc aattgtgtta ttttctatta 3589801 tttgttgtat tatgtctgga tttgttggag cacttggttc aagcctcagt ttactttttc 3589861 gtgataagaa gtatgcctac ccagcaagtt tttttatttg gttcgtactt atactaaaaa 3589921 acaaatcatt aatgttttta ttccaaccgt ttacagaata cggttataat gtacttctcc 3589981 ctatcctatg tttgtctatc tttatttttc taataataat ttctagtatt gttttatatg 3590041 aggcaaaata caatgaaaat taaaagacta ctattaattt tatgtttact actattttta 3590101 gttactttat ggttcaacca gaaccacact tatcttggaa agaattctat cgcgtcatta 3590161 ctatatatga ataatagtac attcggatat agttcaatat ttgcatatac cttgttttat 3590221 attgtcccgt ttcttatgtt acttagtaac ttttttcatt cagaaaaccc ctacaaagta 3590281 atgaggatgg ttaagcgtaa aaattactac aagtctaaaa ttatggagat tgggtttgtt 3590341 tctttacttt tttcttcaat acatactgtt attaatatta cgtgtacaca tattttcttt 3590401 agtaaaaact tgttggtcga agcaaacttt ttatcaattt gtttattaaa catgattagt 3590461 ttagtgtttt tctacttatc agtaggtatt atgtttagac ttacatacga tctgtttaat 3590521 tcagtagcat tagcaatttt tattgtgtat ataattttag atagcttgta tttcggcgtt 3590581 aaattattac ttcctaatgg atattgggaa ccctttagag acttggctat attcacaaat 3590641 atgctcaata gatattggtc aacttcaaat cttataatag tttatattag acagataata 3590701 atagttttta ttttttattt agttggatct tcaatttttt tgaataagga ttataaaaaa 3590761 tgaggattaa aggctttttc ataactttag ttgcgataat atttcaggcg tcattatcga 3590821 gttataataa taataaaaat gtctttcctt ttttagatgg cataccaata agcacctcgg 3590881 gtcattatga gtatcaaaat attttattgt ggtttgtacc tattgtttcc ctaagttttt 3590941 gtttctctgg gagtattaga gatacataca tttcgtatga gcaattaaag ttagtaagag 3591001 aacatagtag agttaaatgg gtaacatctc aattcttaat aattacagtt gtacttttaa 3591061 tctttacttt atctcagatt gctatatttt atatttattc acttgtatct cttcataacc 3591121 ttgatattaa ttccgttatc aataaaagat ttgttatgat gacactcatg tattatctaa 3591181 ccttacttaa cttatttagt tttcaattat ttatggagct ttattataaa tctcaaatag 3591241 cacaattaaa tataagcgtt tatattattt tttcgttaat tttagcaaag aagttagtgc 3591301 aattaaattc tccgaaagtt attcactact ttttaattcc aaactacagt aatggattaa 3591361 gaactgggtt aagctattat tcccaatctg gaactgctat tattgaacca ttattaggtt 3591421 tgtttattat aatcatttta cagatttcaa tagttatatt atctgtctta aagttcaaaa 3591481 aaatagatat gctaaaaagt gagggcttac aatgattgag gtattaaacc taacaaaaaa 3591541 attaaaaaga ctacagtttt agataatatc tcttatacat ttgaaaaagg aacaatttat 3591601 ggactatttg ggagtaatgg ttctggaaag accatgctac ttcgtgcatt atccgggtta 3591661 atagtcccta ctgaagggag tataactatt aaaggtgaac aattacataa agatatctct 3591721 tttcctaaaa gtgtaggatt aattatagaa aatatgcagt tacttcctca gtatgatgct 3591781 tttactaacc ttaaaatttt gtcaaaaatt aaaaagatcg catcagataa tgatatatta 3591841 gattctatta gtagagttgg tttggaaaat tttaatagtg taaaggttag taaattctcg 3591901 ttaggaatga aacaacgatt aaatattgca caggctattt ttgaaaaacc tgatatattg 3591961 ctacttgatg aaccaacaaa tgcgattgat gaaaaaggag ttgcatttgt tcatgacatt 3592021 cttttacaag agaaaaaaag gggagctacc attattatta ctagtcatca caaggaagat 3592081 attatatctt tatgtgacat tgcattagaa atgaatcatg gacgtctaga aacttcagaa 3592141 aaagtaatat ataagaaaga tagttagttt aaactggcta tttcttatcc aatgatagac 3592201 tgcagacaag ttcaactgct gtaatgctag aaaatccaat gaaatgctga taattgcgaa 3592261 gagatatgat cagtcagaaa acaaatctta aaaagaaaaa gtaaattcat caatatttct 3592321 aataaacctg gcaaacaacc tgttcggagg cattatagct acttcactga cgggatattt 3592381 atttgatgtg acaggctcct tacgctcagc tttctggtgc cggttttgtg ttgttgctgg 3592441 gattggtttt ttatgtgttt gtattagggg atgtaaaacg aattaaactg gaataaagag 3592501 tgcttgctga aaagcactct ttttctgcat cgaaagaata cttaagataa gtcactccca 3592561 aaaatcgtaa cagtctgacg gttaaacata aacctctgcc cgttccattt taatacggtt 3592621 tgaacatatc ccaatgagtc ggcgttatac cttcccgcta tccgctggta cgccaataat 3592681 tcgtatacgc cgtctctgtc aaaatcaacc ggatacaagc ccgataaagg attcacccat 3592741 ccttctatcg gcatttttaa cacaccttgg ctgttataaa tctcattcaa atattccctg 3592801 cccttgtaag taaggtcgag gatatacgtt tcgttttgct gatgactgat aacgctcgct 3592861 ttatattgat tttgatacct cacactgtac tttaattcat cattcaatac atctgaattg 3592921 aaaattcgcc ggaactgcct gtttagatag gcaaacacat atgcataaat agcaccgccg 3592981 cttccccctg tgtccattac tactgccaca tcctcaatct tgtcgcctgt catatccccc 3593041 agaaaaagtg acggattgta tcccatattg ttttgaagct gaatccgctg ctcctgatgg 3593101 gttctgccat cacggatcac caatgtgata tttctccata acgggctgcc gggcatttga 3593161 tttccagtta gaaagacctc gtcaataacg ccgtctcccg ttacatcgcc gcgggtagat 3593221 acaatgattg cacgtgagga gacaggctgc cgaaatacgt atggatgttg aacaagtcct 3593281 ctgccttcat aaaaccaata aggagccatt ctgatgtcat acacattcaa ttgtgtcacc 3593341 ttccctaatc agctgaatga atcattatat gcaggaatgg cacatcaaag acatatctta 3593401 cacaccaatt aaatccgtac catatgaatt atcaattaca caaagccact cgccttgcgc 3593461 attcttttta aatacatagg tcgcccttct ttccatcgca tactcggagt cctttttatc 3593521 cgaatcaagc agtgtctgag aaagaacgag taccgtgtca cctgcttcca acaggatcat 3593581 tttcccttgt gtcgggacaa tatgatgatt gaaatagttc gcaatcgtga taaacgcttt 3593641 tttgatttct tccttgcctc gcgcgatcat gcccggcttc acaactaaaa cggcatcttc 3593701 cgaataataa ttcatcagtg tatcaaaatc ttcattttgg attgccaaat cacacgcaga 3593761 gatgatgtct ttcaattgct gttccaaatg aattccccca atcatcatga ttggatatat 3593821 tatacatcgc tagaccactg aaaccttgaa aacaaaatga aaagtatcct tttttcctat 3593881 ataatcaaat agatatattt aacaaagtac ccaagtgaag gggtgaacat tattgtctgc 3593941 ggaagtaacg ttacatgaca atatacatta tgatttaagt gcggattgcc agcactgttt 3594001 tggcctgtgc tgtgtcgcct tgccttatgc gaagtcggca gattttgctt ttgataaaga 3594061 cgggggcacg ccttgccgca acttacaatc aaactatcaa tgttctatac ataaagatct 3594121 cagagaaaaa ggatttcgag gctgctctgc atatgaatgc tttggcgccg gccaaaaagt 3594181 atcccaaatc acttatgagg gaaaggattg gcgaaacagc cccgaaacgg ccaaccagat 3594241 gtttgacgtt tttcctatca tgcagcagct gcacgaaatg ctctggtatt tacatgaagc 3594301 tctttctata gatatagcca agccgattca ttctgaactg agaaccactt tcgaaaaaat 3594361 agaaaggctc accagactca gcaaagaacg cttgctgaca ctgcaggtgg acgagcatcg 3594421 agctgaggtc aatgaatggc tgttaaaaac aagtgaactg gtgcgtgccc aagcccgcca 3594481 tccaaaactc ccgaaaaagg tcagccgggg aagtgtcctg atcggcgcga aactgaaagg 3594541 gcttgatctg cgaggagcaa atctaagagg ggcgctgctc atagccgccg atctgagaaa 3594601 tgccgatttg agaatgacag actttatcgg tgcagatatg agagacgctg atctcagcgg 3594661 cgccgacctg accgggagca tctttttgac acaggcacag gtgaacgccg ccaacggcga 3594721 ttcgaataca aagctgccgc tgtctgtacg aacccctgcc cattggaaat aaaaaaggac 3594781 ccgctaacgg tcctttttta ctgatcaatt caatcctttt tcgttcctct tatccggcat 3594841 tttcacactt cttgccaagt atcccgacag ccataacgca accagcagca tgaaggtgat 3594901 cataccgacg acgcccagcc agtgaaaacc agaccagaat agccctccga ttgttccgaa 3594961 aacacttgaa ccggcgtaat aaaagaacaa atacagcgat gaagcctgtg ctttgttgtg 3595021 aagggctctc ctgcccaccc agctgctggc aactgaatgc cctccgaaaa aaccgaatgt 3595081 aaagagggca atccccagaa ttttcactgc cagcatattg tttatcgtaa ataacgcacc 3595141 tgcaatgacg atgaaaatat tcatcaccaa tattttcgga tagccatacc gatcaaccat 3595201 tcttccaatg aaagacgagc tgaaaatgcc tacaatcatc acaataaaga tccagctgga 3595261 aaatgcttta ttaagcgaat acggcgggcc caacagcaca tacacaatgt aattaaacaa 3595321 ggcaacattg cttccaagca gcaaaaaacc aatgagaaac aagctgaata gtttacggtc 3595381 cctcaagtgg ccgatcagag acattcccaa tttcccgagc ttcaattttc ttggcgtaaa 3595441 atgcctggat ggcggcaaat ttataaaaaa tataacacta gcaatcaaac taatgacacc 3595501 aattgtcccc atcgccatat gccaattcaa gtactcgctc aggagcccgg aaacgatcct 3595561 tccgaaaacg gcgccgattg catttccgct gatatatagc cccatcgctg atccaagact 3595621 tccgggttca atttcttccc caagataagc catcgcaatc gacggaaggc ctgcgagcgc 3595681 aacgccttga atggttctca atacgagcag tgtatgaaag ctcggactaa aggccgatgc 3595741 cagacagaga accgatgcgg ccagcatgga aatacccata ataggcttgc gtccccacac 3595801 ctcggataat gaaccaaaga caagcatgct cacagctaac agcattgtgg taacagataa 3595861 agaaagactc gccgcagtag gcgttacatg aaattcccgc gtgaattcct ccatgagcgg 3595921 ctgtacgcaa tatagaatcg caaatgtatt gaaacccgca gcgaagaaag caaacgtaat 3595981 ttttcgaaaa accggtgtgc cttttcgaat gtatgtcatc gggactttat cggtccctca 3596041 tcatgttgtg gagcactgcc attcataaac aatcatcctt tatttcttac gaattcaaac 3596101 atcctcgagt ctgtttatat tattatctta gcaccgttga tatatgttgt ataatgcata 3596161 taaaatatcc ttttcatgct tatatgtaat aaggagagat gataattgga atgggaacaa 3596221 cttgaatatt ttcaaacact ggcccggatg cagcacgtca cgaaagccgc aaaaagcctc 3596281 tccatcacac agcctgcact ttcacgctct atcgccaggc tggaaaatca tttgggcgtc 3596341 ccgctatttg acaggcaagg acgatccatc agcttaaatc aatacggaca cattttttta 3596401 cgacgggttc aggcgatgat gaaggagtat accgaaggaa aagaagaaat ccaagcctta 3596461 ttaaagccag accaaggcgt agtctctctc ggttttttac atacattagg caccacgctc 3596521 gtgcccgatc tcatcggctc ctttcagcag gaatacccca acatttcctt ccagctgaag 3596581 caaaaccact cttattggct gcttgaacga ttaaaatccg gagatctgga cctctgtctc 3596641 ctcgcttcga ttaagcctga aaatccgatc caatggatca agctgtggag tgaagaactc 3596701 tttgtatttg tgccaaatga tcacccatta gccagtcgcg aaagcattac cctgaatgag 3596761 attgccgggg agcgttttat tttattgaaa aagggctatg cgcttcggat gacggtcgat 3596821 gagctgtttg agaaggccaa tatacagccg aacattatgt ttgaaggaga agaagcaact 3596881 actgccgcag gttttgtggc agccggtctg ggcatatcta ttctcccaga cctgaaaggc 3596941 ttagaccaaa gcaaaatcac caaaatccgc gtcagctggc cggaatgtca gcgtgtcata 3597001 ggaattgcct ggataaaagg caggttttta tcaccggttg ctgagacctt taaacaatat 3597061 gtgatcagcc atttttctga gtaggaagga ttcaagcatg aatgtcaaaa aaatcacgtc 3597121 agaacaggat ttacatacag cgtttgaaat cagaaaggca gtatttgtag aggaacaagg 3597181 ctgtcccatt tcggatgaat tcgatgagtt cgatacactc cacggtgact gccagcacat 3597241 cctggcttat catcagaatg tacctgttgg cactgcacgt gtccgtatcg ttggccacac 3597301 ggggaaactg gaacgaatct gcattctgaa gtcttaccgc aaattcggtt tgggaaaagt 3597361 gatcgtcgat gcattagaac gtattgtaaa agaacaaggc atttctgcct tcaaactgca 3597421 cggccagaca caggcggcag gcttttatga aaagctcggc tatcggactg catcagaaga 3597481 atttatgctg gacggcattc cgcatgtgct gatgacaaaa caagacgatt ctgcgctata 3597541 gattgttcac aaatttgtca cttatgagca tgaacggttc attggtatac taatcaccga 3597601 ttatggagag aaggaatgat tgtatgccag caaataaaaa agaaggcctt atatttggcg 3597661 tgatgatgtg ctttggaatg gtttgcgtca tgtcgattta caatgccatc atcaaccgag 3597721 ccatctacga tttttcactg atgaccgttt ttgaaatggt catcggtttt atgatcgccc 3597781 tcctgttaga tttactgtta gtgggccccc tcgccaagaa gattgcattc cgcatgccgt 3597841 tcgacaagac taaaaaaatt tatgtcatcc ttgccatgtc aacttgtatg gtgattggca 3597901 tggtactttg tatgtctgtg ttcggtttag tgacagcggt tctagcaaat gggctgaacg 3597961 gggacagcct cttcagtgct tatcttatga ttgtgttgaa aaatttcatc ctggcctatc 3598021 cgttgcaatt actgattatg ggcccattag tcagaggagt tttcatgaaa tttgtaaaac 3598081 caaagctcac agccgcaatt taaatagaaa aggagtgagc ctgacactca ctccttttgc 3598141 tcatgaatcg aatgtaaaac aagctccgca aaagcctctg cggcaggcag ctgccatttt 3598201 ttctttttgg gtgtgagtaa atcggatcga gggcttcacc atgctggaga tttttcagct 3598261 tatgtttttc acttccatta atccctatac cttaccacat agtttttata caattcttcg 3598321 ttataaagga tttcttcgcc atgtgaagag caaatgagcg ttggtttgat ttgatctatg 3598381 attgagccgc tgtcgatgtt ctcatttata tcaacactga atcttcttat aggtgggtgt 3598441 aaatcctcct tacttgtgat aaaaaggtcg cccgtcaata gcgtacgatc gattttatga 3598501 taatacacaa catgccccgg cgaatggcca ggtgttaaat agtatttcag aggcagatga 3598561 gcaagcgttt gctccgtcag cggctgtaca atatgggcta cccctgtgtt ctccacttca 3598621 tttttgttcg gatatggctc ttccccattg atgtacttta gttctttctg gtgcgcaaaa 3598681 atcggaatat caaatctctc taaccatttt gatgcacccc cgatatgatc actgtggcca 3598741 tgggtaagca aaatggcttt tggattgccg atcgctaacg ctgccctaat ttgagcatca 3598801 gcaaaacgtt ctattcccgt atcaacaata taaacatcat caccatcttt gataaaccag 3598861 gtatgaaccg gaatacgaag aggcacatca agctcaaatt cacattgaaa gacatgttct 3598921 gatagttgtc tcaaattcac gcaaaccatc tcctgtggaa attttttgat agttttaaag 3598981 aaaacagaag tgaacggact attttcaccc acgctcgagc tgactggatt cttgagagga 3599041 aacgccgatt ttcgccagca tcagctcaac ttgttaacgt tgtccattaa taatcccttt 3599101 tgttcccctt cttcacatat tcccaatcac gttctatatt cttcctcact ctatgaagga 3599161 gtgcagaaat ggtttccttt tcctctgaag taaaaccgga caaggccact tccgtggaat 3599221 gttctccttc tcttcttaac aatggatata cctttttccc tttctcagtc gggaacagtt 3599281 tttttatttt tttattttgc tcatccggca gtttttgaat aaatccctgc atttccagct 3599341 tcttaatggc ccgcgcggcc gttgtccggt ccacttttat catttccgcc aatttttctt 3599401 gaataattcc cggattttcg tatatacgca cgagatagag atactgccct cttgttaagt 3599461 ctaaatcttt aaattcgatg ttgcttatgg aatccaacgc tcttgctatc atgccgatct 3599521 cacgcaaaat atcattcatt cctaaaaccc ctcacgtatt tttgttgcaa ttacaacaaa 3599581 aatgttttaa ccttactatt ataagaccac atgcgtgctg tacagtccag actaatatca 3599641 gaaaaggatt gattcataat gaatataaaa agaataacaa ctgaagctga tttacatgaa 3599701 gctttaaaga ttagaagagg cgttttcatt gaggagcaac atgtgtctga agccgatgag 3599761 ttcgatgaat ttgatacgct tcaggaacaa tgccagcata tcttggtata tcatgagaat 3599821 cagcctgtcg gcaccggacg cgcgcgcatc gttggccata cagcaaagct ggaaagaatc 3599881 tgcatcctaa aaccttaccg taagtacgga ttggggaaga tcatcgtaag cgggttagag 3599941 gaaatcatga aagaaaaagg actgacttca tataagctgc atggtcaaac acaagcggca 3600001 ggcttttatc aaaaactggg ctaccagatt tcttcacagg aatttatgga ggacggcatc 3600061 cctcacgtct tgatgacaaa agaaatatcg cggaatataa catgaaatat atgtattacg 3600121 gaataggcat actcatatta agtttgggca tttccttaac catacaatca ggactgggca 3600181 catcaccctt cgatgccctt ttggttggtc tgtcaaaaaa aatcggtctt accgtaggaa 3600241 gctgggaggt ccttatttct gtgatcctct taatctgcaa cgctatatta acgagaaaaa 3600301 aacctatttt gctgggcttg attacagcat tcattactgg aataggcatt gacctatggt 3600361 tgtttgttgt aaaaaacacc atctatctaa actcgttgtt aagcaaactg atttgttttg 3600421 gaattggttt ggtgctcatc ggtcttggaa cagccatcta tcttcagacg aaattcgcat 3600481 caacaccgat cgatcattta acacttatta tccgagatct ctccaaaaga acaatattgt 3600541 tttcaaggac attggtatac gctcttttct tagtattagc catcatcttt aaaggcccta 3600601 tcggcatcgg aactctttta acggtttgtt tgggaggaat gctccttcac gtttttatgc 3600661 ctattgtgga aagacatttc ttatcaaaga atagaagagg ttattaagaa acctcttctc 3600721 gatccaaaaa acgaaacgca aaacaagccc cgtttcgttg tcaattcttt atctctggta 3600781 ctgttgaggt tttataatca attaaaattt atagtaccaa aaaatcgcaa tttcatttgc 3600841 tgttggaaag ttggaataaa gcatcgtatc aaccgcacct attataaagt gatgtttggc 3600901 ataaaaatga caagctgaaa tattaatatc ttgggtttca agcataagac cacaaaaatg 3600961 attctccttt gcccactcaa tcgctttatg taataatgct gttccaacac ctttttttct 3601021 atagtctttt gccacggcaa tgtcctctat tagtgcatac ccattccagt tagaacggat 3601081 cttaatccgg ccaatgcagt tgttttcaag ataatataaa aaagccgctt tcccctcttc 3601141 ttcaacataa ctaacatcca tgtcatcatc ttcatattgt ttaaaataag gtttagaaaa 3601201 tcgttcctca gtatatgtcc aaacaccgtt ttcaaaagca ggtatcattc tcccaaaaac 3601261 aacgaaaggt tcgtttggtt tattgaaatc tttcatattc aaatgagtca ttttcatgat 3601321 catatcaatc tccgccaatc gagataatat ttagtaaact cgtttcgata ctattcaaca 3601381 acagcttcca aaagtgtact ctttaagaga acagcattag ataaggcatc cattacctta 3601441 tatatttcac tatcttaatg aggtatttca acagaggctt gtggtacagt aaaaaggaat 3601501 agaaacaaga gaaaagaaga tgaacctatg cccactaaca ataaactcaa tgagaaatat 3601561 catacttcct tcaactcgcc cacaaccctg ttgactagta tccgtggaga gaggaagctt 3601621 tgacacagct tctgccattg atgacatctc tattgaagta tccaaaggac aaccaaggat 3601681 cgctctttga ctttttcaag aagaaagtag agtgaataaa ggagtgattg agtatgttaa 3601741 caagagaaga tatctttaaa cacgtcaaag aaaaatacgg tacatcgcct gattacccgt 3601801 gggagaaata cccaaactat gcttctttga gacatacatc aaacaaaaaa tggtacggtc 3601861 ttatcatgaa tgttctccca gaaaaattag gcttggatgg tcatggcgaa atagatattc 3601921 taaatctaaa atgtccccct gaaataagtg atcgcttaag aaacggggaa aatatcttac 3601981 ccggatatca tatggataag gaacattgga tttcaattgt tttagaacgg acagatccag 3602041 aaggcgaaat ctataactta atcgagcaga gctttcattt aaccaagtga agataaagag 3602101 tgttcctgct aatcaagctg cgaagagtag tgggcacttt cattttagga tactgttctt 3602161 cactctgtcc acaaacgcaa cttagttcat ctggtgcgag agtgggagaa gaatttcaac 3602221 caacttctta tgtaaaagga tgaatagtta tgacaaataa cttaaaacag agaagaatca 3602281 ttttagattt agcagttact ttagatggtt ttattgaagg gaaaaatgga gaagttgatt 3602341 ggtgtattat ggaccctgat atggggttta ctgatttttt aaatcaaatt gatactattt 3602401 tatatggtag aaaaagcttc gatttatggg gacaatacat tccaaaaaat gaagaccctg 3602461 atacagaaaa ggaactttgg aaattggttc atagtaaaaa gaaatatgtt ttttccagaa 3602521 cacaaaatga gattgataat caagccatat ttataaatga taatattctt gaagaagtaa 3602581 ataaattgaa gaaaaatcct ggtaaagaca tctggctata tggtggagcg agtctcatta 3602641 caacttttat aaatttgggg cttgttgatg aatttagatt atctattcac cctgttgttt 3602701 tgggagaagg aaaaccgttg tttattgatg taaaacagag gataaattta aaaatggtga 3602761 atacaagaac attttcctct ggcgttgtgc aaatcgttta tcattggaat ggctaacatt 3602821 gtaaagtaac actcgacagt aatccttctt attgaactaa aggggaatcc ataaataatg 3602881 ggttcccctt aatatactat ggaattatca atatcaaatt ttctgtaata aaagaggatt 3602941 gaaaaggacg atgtctcctc aattaacatc attaagcatt atagtatatt ttcttctccc 3603001 tcttttaagt aatcggctaa gttttgtatt tataaaaaaa cgaaagaagg tgatccaatg 3603061 cctactaaca ataaacccaa tagattaatc gctgagaaat ctacttattt tacttcaaca 3603121 tgctcataac cctgtggact ggttcccttg gggagaagaa gcatatgaaa aagcgaaacg 3603181 cgaaaacaag cctgttctcg tatctattgg gtatagctaa cgatggctaa tctaaagaac 3603241 atgctattga tgccatgttt attcatttta caaaaaagga tcaaccttga attactttca 3603301 caagattgat cctttcactc atttagccat gtctccgcga acgtttatat acattcaaga 3603361 ttactagcca acaaataaca atgattcctg caaaaagtat gagcatattg ctatacaaat 3603421 aggtagagtg atcaacgtca ataggcagca gcctatgatc taggaagccg atagataata 3603481 aaccgcctac aatcgcaata cccgttccct ctgataaaaa gctcgtgaaa ttaagcaaac 3603541 tcattccagc gcccgcttcc ttttctttca aactgctaga cacaactgta gatataactg 3603601 tttttgtgaa agatagcccc ccaaaaacaa aaattactat aattgtcatg atccatggtg 3603661 ctgcatctat aaaaaaggca gcgattaaaa agccggaaga aagcaatgca cttccaatag 3603721 ttagtacata caaggaacct ttccgatcaa caagcaatcc cccaatgtaa ccaaagatga 3603781 tgacactcat tgttccgggg aaaataatgc cgcttccaat tgctgcagta cttaaatggt 3603841 gaacatcttt catcatgtaa ggaaccatag agacaaatcc tgctactgta ccaaatatta 3603901 gtcctccgca aagggttcca atcacaaaaa agacgttttt ccctaattca gggtcaacaa 3603961 aagggtcctg agctttccta atgtgttgca caaatatgaa gaaagcaagg atactgatga 3604021 tcagaaaaga aaatctataa gatgttgtaa acagcataaa aaatacgata cctgcagaca 3604081 tcaatataat ccctgccata tcaatgtgtc ctcttattct ctcttccttt ttcaacaatt 3604141 ttataaggaa tggaacggtg ataattgttg cagttggaat aagcagcaaa tacgaccaat 3604201 ggatataatg agcaaccatt ccgccaatag ctggcccaac accttctccc attgctacca 3604261 gggacccgat caggccaaat gctttccccc tgttctcttt tggaatatag cgcgcaacga 3604321 caaccatcac aagagctggg aatgcggctg caccaattcc ttgaataaat cgggctagaa 3604381 tgagaatagg aaagaaagag tgtccaacaa atccaatgat cgaccctaag ccatttacca 3604441 taatcccaaa tagaagcaga tttttgatgc ccagctggtc tgatagcttt ccatatagag 3604501 ctgttccaat ggagaaggtt aacataaagg ctgtattcac ccagtttgca cttgctggca 3604561 gtttattaaa ctcgttggca atatcaggta atgagacgtt cagaaccatt tcatttaata 3604621 cgctgaaaaa tgatagaaca caaagccaaa tcaaaacttg attgtgccgt aaagttgact 3604681 gtgaataaga cgtattcaca atttcccctc cattaatgag ggcagacgca gtttataggg 3604741 tcattgatac gcttccctct tttaattgta ccctgttcat tttattgcac ttcataataa 3604801 ctccccctac atttgattga tatgatctta ttatatatag actaaggatt aaacttttac 3604861 tttttttata aaaatttgac cagattgcga aacaaggaaa aacgttattc gcatttatct 3604921 caagtggcaa aatgaaacat tagtttatat tttcacatca caattatcga taagcagtca 3604981 gttattgtat ttgtttagga taactgtggt aacctgaata taaccaactt aggaagaagg 3605041 tgatcccatg ccaaataaaa gtaaacccaa tagattaatc gctgaaaagt ctccttattt 3605101 actccaacac gcccacaacc ctgtggactg gttcccgtgg ggagaagaag catttgcaaa 3605161 agcaaaacgc gaaaacaagc cggttctggt cagcatcggt tattcgacga cttgtcattg 3605221 gtggcctggg ataatcaaat cgtgtggaac tccattaaaa gataacagaa gccattttaa 3605281 acgataatac tatttgttca aacaatacag tctacctttt atttcattca ttttctaaaa 3605341 cctgtaatcc gtaaccacgc ggtagcaggt ttttttattt gcttgactta gagttaactc 3605401 taaattgtaa actaacttta attaaatgag agggatgatg ttgttgtatt ccattagtaa 3605461 agctgctgag aagactagta ttagttcgta tacattaaga tattacgaaa agattgggtt 3605521 acttccacca ccaaaacgaa aaaacagtgg aaggcgtttt tatacggaga ctgatattca 3605581 gttcatgtta ttcctgaaaa gtttaaagga aacaggtatg tctttggagg atattaatga 3605641 gtttgtcaaa gacggatgca ttttggaaaa aatcaattcg gatgttaaat cggcacaact 3605701 ctccccatct ataaataaac gtattgagat tttaaccaag cacttagaga aaatggaaat 3605761 taaaaaaagg gagctggaag aagtgatttc tactacaaaa ggaaaactgg atacatatta 3605821 ttcaattttg aaagaggaag tggaaaacaa atgaaacatt taaatatata cataatgtta 3605881 cttggcttct ctattttcac gggagctact tttaatcttg caaaatatac agttggatat 3605941 ttttctccat cgtcttctgc ggcatggcgt ttcggtttag cggctgcagt gatgctcatc 3606001 attttgattt ttactgaagg tataaagaag agtcaattac ggaaaaacgc cgtttcatac 3606061 attgttcttg gaattatagg aatctttgga tttaatgcct tgttttttgt tggtttaaaa 3606121 tatacatctc ccgttaacgg agcattaata atggggctga atcctttatt aacagcaatt 3606181 ctcgctcgaa ttatcttaaa ggacaacatg acaaaaaaac aagtactcgg catattcttt 3606241 gcattcatcg gtgtattgtt agtcattaca caaggttcta tcgaaaccat taaaacctta 3606301 tcaatttcag gaggagactt aataatcttt acaggtaacg tttgttgggc actttatggc 3606361 gtacttggac gtcggtttgt aaaggatggt acaccgctat ctacaaccac ttatacgatg 3606421 gttattggtg ctgttagttt aatagtagtt tccttattta catccaaacc tgtttcttta 3606481 tcgaacatcc cgattggagt ttggggggca attgctttta tggctttttt tacaagtgtt 3606541 ttgggttacc tatggtggaa tcaggggatt aaagagattg gagctagtaa aacatcttta 3606601 tttttcaacc ttgttcccgt tgtaacgatg attatttcat ttgccgttgg aacaccaata 3606661 aaggtatttc aagttattgg ggctgtgcta gttatattag gcgttttaac cgcttcgggg 3606721 gtaatacgta ttcctaagta caatactaaa gaacagtcag ctatataaag aaatagggag 3606781 tatttttgag aaaatgtgtt aagttaaata tacactaatt ataggaagaa ggtgatccca 3606841 tgccaaacaa aagtaaaccc aatagattaa tcaatgagaa atcaccatat ttactccaac 3606901 acgcccacaa ccctgtggac tggttcccgt ggggagaaga agcttttgaa aaagcaaaac 3606961 gcgaaaacaa gccggttctg gtcagcatcg gttattcgac ttgtcattgg tgccacgtga 3607021 tggcccacga aagctttgaa gacgaagaaa tcgcgcgtct tctcaatgaa cggtttgtgg 3607081 cgattaaagt cgaccgggaa gagcggcctg atgtggattc tgtttatatg agaatctgcc 3607141 agctgatgac cgggcagggc ggctggccgc tgaatgtgtt tatcacgcct gatcaaaagc 3607201 cgttttacgc gggtacatat tttccaaaga cgagcaaatt caatcgtccc ggttttgttg 3607261 atgtgcttga gcatctgtct gagacgtttg cgaacgaccg cgagcatgtc gaggatattg 3607321 cggagaacgc cgctaaacat ttgcagacca aaacagctgc aaaaactggt gagggcctta 3607381 gcgaatcagc gattcaccgg acattccagc agcttgccag cgggtttgac acgatctacg 3607441 gcggtttcgg gcaggcaccg aaatttccaa tgcctcatat gctgatgtat ttgctacgtt 3607501 atgatcacaa tacagggcag gagaacgctc tatacaacgt gacgaaaaca ttggacagca 3607561 tggcgaatgg cggcatttac gatcatatcg gctatgggtt cgcccgctat tcgaccgatg 3607621 acgagtggct cgttccccac tttgaaaaaa tgctgtacga caatgcgctg ctgctgaccg 3607681 cttatacaga agcctatcag gtcacgcaaa acagccgcta taaagagatt tgtgagcaga 3607741 tcattacgtt cattcagagg gaaatgactc atgaagacgg aagctttttc tcggctttgg 3607801 acgcggacac agaaggagaa gaaggaaagt actacgtgtg gtcaaaggaa gagattctaa 3607861 aaacgctcgg ggacgatctc ggaacgctgt attgccaagt gtatgacatc actgaagaag 3607921 gaaactttga aggcaaaaat attcctaacc tcattcacac aaagcgagaa caaatcaaag 3607981 aggatgccgg gttaaccgaa aaagagctca gtctcaaact cgaagacgca agacagcagc 3608041 tcttgaagac acgcgaggaa agaacctatc cgcatgtcga tgataaagtg cttacctcat 3608101 ggaacgcgct gatgatcgcg ggtcttgcga aagcggcaaa ggtataccag gagccgaaat 3608161 atctcagcct agcgaaagac gccatcacat ttattgaaaa caaattaatc atcgacggcc 3608221 gtgtgatggt ccgatatcgt gatggcgaag tgaaaaacaa aggctttatc gacgattacg 3608281 cttttctcct atgggcttat ctggatctct atgaagcttc gtttgatctt tcttatttac 3608341 aaaaagcgaa gaaactgaca gacgatatga tcagcttatt ttgggatgag gagcatggcg 3608401 gattctactt caccggacac gatgcagaag ccttaatcgt acgggaaaaa gaagtgtacg 3608461 acggcgccgt gccttcagga aacagtgtgg cagctgttca gctgctgcgt ctcgggcaag 3608521 tcacaggcga cttatcactg atcgaaaaag cggaaacaat gttttccgtg ttcaagccag 3608581 acatagaagc gtatccgagc ggccatgctt tctttatgca aagtgtgtta aggcatctga 3608641 tgcctaaaaa agaaatcgtg atttttggca gcgcagacga tccagccaga aaacaaatta 3608701 tagcggagct tcaaaaagcc tttaagccca acgactccat tctggtggca gagcagcccg 3608761 agcaatgcaa agacattgcg ccatttgcag cagactaccg catcatagac ggcaaaacaa 3608821 ccgtttatat ttgtgaaaac ttcgcctgcc agcaaccgac aacaaatatt gaagaagcga 3608881 tccacacatt aataagcagc agggattaag acccttgctg cttacttttt gatttcttat 3608941 ggtaccataa agcgatcccc gcaaacacaa ggttgaccgc tatcgtaaag aaagcctccc 3609001 acatcgggtt cccccgcgta acggtaaaca gagaaggaat tcctccatac acactgtttt 3609061 tttctgtaat aaacatacac aaaaacatat tattcgcggc atgggcgcca agtgatattt 3609121 cgatgctccc agttttaatc gtgtaatacg tccacacaaa cccaaatgtt aagtactcaa 3609181 ttcctgccca gacagcgcca ttgttcattt ctggattcgc aaaatgcaat acgccaaaca 3609241 atcctccgac aatcagtgtc aaaaatagag gatttttcgt caatctcccg aaagcttgaa 3609301 gcaaaaatcc cctgaaaaat agttcctcag ctgatgtctg aatcggaacc aaaatgaggg 3609361 cagccgctag cagccagata aatcgtgatg cattaaactc ttgcattgaa tagctatcag 3609421 gatgaatcac aaaatcaatc aattgtacgg cgatcattag caagaaataa gcaataaaac 3609481 caaaggaaat tctccgccaa ttcatctttg aatttggtgt tatcaccgtt cggaaaggcc 3609541 gcttcaaaat aaagcgcaca gccagccaaa ctcccggaat ggcgaataaa taaatcacat 3609601 gggacaaata aagatctacg aggggatcac tcagcacagc ttcatccaaa tcaaacgtga 3609661 tattgggatt cacaataacc gtgaacaata tagcgaaaag gtaagctata ttccctaata 3609721 catataaccc taccatcacc aaaaaagcga aaaaatatct ccacaacgta ttgtttcctt 3609781 ctataggacg gataaatgaa ttcattcctt ctatgtctct tcctttcaat gagaatatta 3609841 ctatatattt gcataaattg gtctatgaat ctactgtttt ggaaatcttt taagcaaaat 3609901 taaaatataa agtgtgaatt tagttcttcc atctagtgat ttgaactctg ttgccaatga 3609961 accaagatac ttataatagt cccaagaggg gaattttcag tcttttctac tactcaaaag 3610021 ggggtttttt atgaatacga tcttcaaaca aaagaataca catcctttct caaacgcagc 3610081 gaatcgttta gaccgccttc cgatttcacg cgttcatttc caagtgttaa ccgctctcgg 3610141 cattgtttat ttctttgatc tcgcagattt atttaccctc agcaacgtag cgccggcact 3610201 gatcgagcat tggggcatcc cgctttcaac tattgctaac gtaacggccg cttcgttttt 3610261 aggcatgttt ttaggcgctt cactgggcgg acggctgtcc gatcgaatcg gccgcaaaaa 3610321 agccttaaat ctatttgtct ttgttttctc aatcgcatcg ctatgcaatg ctgcggcatg 3610381 ggacattcca tctttaatga cattccgttt cctcaccgga tttggcgttg cagccgccat 3610441 ggtcattacg aatagctatt tggcggaatt tttcccttca agtgtacgtg gaaaatatat 3610501 ttctttttgt gccatgattg gattgattgg ggttccgatc accaacattg tgtctgcctt 3610561 tgtcattcct cttggttcat ggggatggag gctagtattt gtatggggtg ccgtcggcct 3610621 tatttatttt ttcttcatcc accgtctgga agagtcacct cgctggcacg aaaatcgcgg 3610681 ggaatatgcg aaagccgatg cgatcctcac ccgaattgaa gaacaggttg aaaaggagaa 3610741 aggcccgctt ccggcagcat cccagcctaa agtaagcgaa actgttaagc agaatgcagg 3610801 ttacgcaggc ttattgaaag gcagaaacct caaaattacc atcgtattat ctgctgtatg 3610861 gatttttgaa acgtttgggt tttacggatt tgcttcatgg gttccaagcc tgctaaaaag 3610921 caatggcgta accatggaaa atacattatg gtataacgta ttgcattccg tcggcgctcc 3610981 acttggcgca ctgctcggct ccatgatttc cgaaagattt caaagaaaat ggattttagc 3611041 tgcgagtgcg tttctgacgg ccatcgccgg gctcttatat ggtatgactt ttattcccat 3611101 catgatcatt gtatttggtt ttatcgtgaa tatcacagaa cgggtcttta cctcgaactt 3611161 atacgcctat acatctgaac cttatccgac tgaataccgc tcgtctggca gcggtttagc 3611221 ctatggtctt ggccgttttt caaacatttt tggctcattg cttgtcggat ttattgccgt 3611281 tcagctcggc tatatcagcg tcttcttatt tattgggggc tgttggctcg catgctcctt 3611341 gctgttaatc ttcttcggtc ctaatacgaa tgcaaaacag atttaaaaaa gtcagtgcgg 3611401 atctgccgca ctgatctcat tacaattgct tcaaaatcct tgcggggttt ccgcctacaa 3611461 cagtattagc gggtacatcc ttagtgacaa cagatccaga agcaatcact gcgttatcac 3611521 cgattgtcac tcccgggtta atcaccgccc ggcctccaat ccaaacttga tctccaattg 3611581 tcacaggctt accgaactcc ttcccggatt tcctttcgat cggatcaaga ggatgaccgg 3611641 ccgtgtagat atgtacacct ggcgcaatca aacaatgaca gccgatacgc acctcacaca 3611701 catctaaaat gacacagtca aaattaacaa atgtatgatc tccgatatga atgtgatagc 3611761 cataatcaca gcggaatgtc ggcaaaatcg tgacttgatc cccaaccgaa ccgagcagct 3611821 ccttcaaaag cttcgtccgc actgcatcat cttccggtgt ttcgttgtat tgtctaatca 3611881 gctgtctcgc atgcttgcgt tctagtaata gttgttgatc ttccgaattg tataattctc 3611941 cggctgccat tttttctttt tctgtcctca gcatttaagt cactccagat gtcagattgt 3612001 aatctcgatc aaatttcctt catcatcctc aatcacgctt tcatagtagc cgtctcctgt 3612061 tgtcctcggg ccgtttacta ctgcgaaacc atccgccttc aatcgatcag tcagttcgtc 3612121 aactttctcc cggctcccaa cggaaaaggc aatatgtgcc cagcctgtca ttgtttgtga 3612181 gggcggatcg gtcacattcc cttttttcat aatttccagc cttgctccgg aatcaaacgt 3612241 aataaaataa gacttaaaat cttttttctc attatgatac aaatcattcg cttcgccatt 3612301 aaaatacgat tcataaaaag acttcattcg ctctaaatca ttgacccaga ccgctgtatg 3612361 ttcaatctgc atttcttcct cctccttcgc cttcaatgaa gttataaggt atgaaatgca 3612421 tttcagttca agcttttttc ttaaatttat gctgaatttt gatatcagcg ggttcatcct 3612481 gcaaaaatag agaaaatgct gcgatgccga gctgctcaag attcaaatca agcgacggaa 3612541 aaccaagaac acggctgata gaagtatttc cctcgcctat gatttcaaca tcccaattat 3612601 tctttttggc aaatagatga attccagctg ccacttcatc actatttgca taaatagcag 3612661 tcggaacccg cccgctcata taaaaatgtt cagctgccag ctcaccatca ttcatatcgt 3612721 tgcatccgga cagcatatgg cggtcttcca accttccgca gacagcttta taggccgcag 3612781 ctttatcagc cgtgctcggg ctcctatcag cttctctgac acacgtaaaa gcaatattct 3612841 catgcccgcg gctctttaaa tagcgaaagc tctctgcata agcagttttt ctgtcattaa 3612901 aagcacaagg gacatcaatg tctccggtat cctcacaagc gatgaccggc ccatattcct 3612961 gataagctaa aatgctgtcc caatgattgg cgcgggaagt aatgatgaga ccgtctattt 3613021 tcttcgttct taacagctct aaatatttga tttcaatatc ggggttataa ttggtgggga 3613081 gaagggtcgt tgcatactca tgctgaaaag ccgccttggt gattccgtta acgattttat 3613141 caaagcaggg atgatcgcta taaggcagaa tcacaccgac cgtatgggtt ttcccgcgaa 3613201 tgagatcgat tgcggttcga tttggtgtat aatccaattc cttcatgact tgatgaacaa 3613261 gctttctctt ttcttcagat acatacggat gatgattcaa tacacgcgag acagtcgaaa 3613321 cagatacatt tgccagtctt gcgatctctt ttatatttgc catctctttc tccttttcat 3613381 ataaaaaaag cagtaagtgt aaaatcctta ctgctatctc atcatatatt gatgataagt 3613441 tcaacaggac aatggtcgga acccatgacg tccgctgata tgctggcatc ttcaatctgt 3613501 tccttaaggc tttcagaaac aacaaaataa tcaatccgcc atccaatatt tctgtcccgg 3613561 gcgccggcac gatacgacca ccaggaataa gcgccttcaa gatcaggata aacatgacga 3613621 aaagaatcaa caaagccagc ttctaagaaa cgagtgaatg cctctctttc ttgatctgaa 3613681 aatccagcgt tattccggtt cgcctttgga tttttcaagt caatctcctg atgggctaca 3613741 ttcaaatcac cgcataaaat cactggtttt ttctgatcca attcaagaat ataagacagt 3613801 aaagcctctt cccattgcat gcggtaatca atccgctcta atccccttct ggaattgggc 3613861 gtgtaaacag tcatcacaaa cacgttttca aattccagcg taatcactct gccttcttgg 3613921 tcatgctctt ctactccgat accgtagatg acctgcagcg gttcttgctt agaaaaaaca 3613981 gctgtgccgg aatatccttt tttcactgca taattccagt acacatgata gtcttcaggc 3614041 tggagatcaa cctggccgtc ctgtatcttc gtttcctgaa gacatataat atctgcatcc 3614101 tcttctttca aataagagag gaaatccatt tttctcatca cagcccgcag gccgtttaca 3614161 ttccatgaaa tcaacttcat gtttcatcct cccccctata aaaaagagca agaacccgaa 3614221 ggtccttgct ctttacatat cagcttactc accgcttacg tatggaagta aagccatttg 3614281 acgtgcgcgt ttgatcgctg cagtcaattt acgttggtat ttagcgtttg ttccagttac 3614341 acgacgtggt aaaattttac cgcgctcaga aacaaacttt ttaagaagat ctacatcttt 3614401 gtagtcgatg tgcgtgatac cgttagaagt gaaataacac actttacggc gtttcgcacg 3614461 accgcctctg cgtcctcctg ccattgtcat ttccctcctt tctttttcat tttaggcgat 3614521 aatcacatta gaatggaaga tcatcatccg agatgtcaat cggtttgccg tcgttggcaa 3614581 atgggtcatc attaaagctg ttcccctgat tgcgtctctg gttgttttga tttcccccaa 3614641 atggattatc attttggcct ccgccaaagt actggcctcc gccgctgttt ccttcgttgt 3614701 atccacctga accagaaccg ccgccgtttt tcggctcaag aaattgaaca ctttcagctt 3614761 ggacctctgt cacgaagaca cgctgtcctt gctggttttc atagtttctt gtttgtaaac 3614821 ggccatctac gcctgcaagg cttccttttt tcaagaagtt tgcaacgttt tcggcttgtc 3614881 ttctccaagt gacacaatta atgaaatcgg cctcacgttc tccggactgg ttcgtaaatg 3614941 tacgattcac agcaagagta aacgtagcaa cagccgcacc gtttggcgta taacgaagct 3615001 ctgggtcttt tgtcagtctt ccgactaata caactcggtt aagcataaga aagaccacct 3615061 tttaccatta tatatttcaa aattgcttat tcttcttctt taacaacaat gtggcgaatg 3615121 atatcgtcac tgatcttagc tagacggtca aattcttgaa ctgccgcagc gtcagattga 3615181 acgtttacga tttggtagaa accgtcgcgg aaatcgttga tttcgtaagc aagacgacgt 3615241 ttaccccaat cctttgttcc agtgatctcc gcaccgttag aagtcagaac gttgttgaaa 3615301 cgctcgataa ctgctttttt agactcttcg tcaatgtttg ggcggataat gtacataact 3615361 tcgtactttc tcatctgttt gcacctcctt ttggactaag cggcccataa tgggcaagga 3615421 gcaataattc tattactcac aattttatat tataccaaag ctcttgtccc tttacaactg 3615481 catcctatac attaaatcgg aaatgaataa catctccgtc ttggaccaca tattctttcc 3615541 cttcaaggcg gacttttcct gcctctttag ctcctgccat accgccgccc gcaagaagat 3615601 cctcataagc aactgtctca gcacgaatga agccccgctc aaagtcacta tgaataattc 3615661 ctgcacactc aggggctttc atgccttttt tgaatgtcca agctctgact tcctgttctc 3615721 cggctgtgaa atatgttgcg aggccgagaa gagagtaaga cgctttgatc agctgatcaa 3615781 gacctgattc ttgaatgccc agctcttcca agaacatttg cttttcttcg ccttcaagct 3615841 cagcgatttc agattcgatt tttgcacaca caacgataac ttctgcgttt tcgccggcag 3615901 cgtactcgcg aatcttcgct acattttcat tgccagatgg atcagcaact tcatcttcac 3615961 ttacgttggc cacgtacaaa ataggcttcg aagtcagtaa atggagctgc ttcacaagct 3616021 tttgctgctc ttcagtgaat tctacagatc gagcaggctt ttcactctca aacgcttctt 3616081 tcagtttaga taaaatctca aactcaaata cagcgtcttt atctttttgc ttcgcaagct 3616141 tgctgacgcg tgtaatccgc ttttcaactg tttccatatc agcgaggatc agctcaaggt 3616201 tgatcgtttc aatgtcatca atcggatcaa cctttccgga aacgtgtgta atgttgtcat 3616261 cggaaaaagc acggacaacg tggcaaatcg cgtcaacttg gcgaatatga gataggaact 3616321 tgttgccgag tccttctcct ttagatgcgc cctttacaat ccctgcaata tcagtgaatt 3616381 caaaagcagt cggcacagtc ttcttcgggt tgaccagctc agtcagcttt tgcagacgat 3616441 catccggcac ctctacaatt cccacgttcg gatcaattgt acagaacggg tagttggctg 3616501 attcggcacc ggcctgtgta attgcgttaa atagtgttga ttttccgacg ttcggcaaac 3616561 caacaattcc agctgttaaa gccattcttt catctcctct atataaaacc gtcattgtat 3616621 gaacgtattt tgaacctaga gcaattataa ggaggttcac tggaaaagac aagctgacaa 3616681 aaaagcattt tcagcttgcc aatccctttg attatgcttt tttcaagcct actaaacagt 3616741 caaaaagcgt acttcccatt ccattatcag aatttgtatc atttgtcagt gcattgactg 3616801 accctccaaa agccgcccac atgccttcat ctatattaat cgtcttcgca tgagcctgct 3616861 tcatcacttt caccttgccc ttcatgcttc cgcggtcatt aaagatgaca acttcgtctc 3616921 catcctgaag atcctgccca gccgctatat ctggagaaat atcgacctga acgtgctgaa 3616981 gcttttcaat aaacggcaca tgctgtgaat gattggaacg ctgcggatga atggataaga 3617041 gcgtataagg gtactttcca gctaactcct cattatggaa aacagattct tcgggcacat 3617101 ttaattgaag cgagccgcta aatccttttt gctcagctag cgacgaagta aattcaaatt 3617161 ttccactcgg cgtcaaaaac tgataatcat cccacggcac ctgttttact ggaagaggga 3617221 ggtggccttt ttcttttaaa cgctcaagtg tcacatcctc tgcttccaat gaagaaagcc 3617281 ccatctctaa aaattcttga gtgctgtatt caaacagctc gccaaaccca agacgttttg 3617341 caagctctga ccagatccag ctgtccgatt tcgcttcacc ctgcggctcc acaagcttct 3617401 tcccgtactg aacataatga tgatacatac tggaatagta gatatcttct tcttcaaaaa 3617461 cagtggcagt cggcaaaaca taatcacaca gctctgcggt atccgtcata atggaatcaa 3617521 tcgcgaccgt cattggaacc ttttcaaatg cttgtctcac cttatttgta ttcggcacct 3617581 gagtcagcgg atttccgcac gtcacaataa tcatctcaat cgcaggatca gcagcggtca 3617641 acacttcttc agcctgtgtc atcattgaaa aagaacggga tgttgttttt aattccggca 3617701 gcgtcagctt tgtttttgca aagctctcac caatctggac atttccgaaa ttcgcgccgc 3617761 cgcccttaat tccgacattt ccgcttgccg ccacaagtgc atcaatccaa cgaatcgttc 3617821 ccccgccgtt tttatatcgc tgcatgccaa gccccataaa agtagacacc ggaccatcag 3617881 catacaaacc tgccaaatac tccagctcct ccatagaagt ttctgttttc acaataaact 3617941 cttccagaga aacggtcttc aaaagctctt tcacatcatc aaaaccgaca gaatgctcag 3618001 aaataaacgt ttcatccgtt cttcccatct caatcagaac cttcaaaacg gctgccgcaa 3618061 gccagccgtc cattccaggc tttacagaga tatagcggtc ggcaagctta gcagtcgggt 3618121 tgaagatcgg atcaatcacc gtaatcgtgg cgcccttctt tttcacctgc tgcaagtgat 3618181 ggtataagtg catatttgtt cttgatacat ttcttcccca cacaacaaca tgcttgctgt 3618241 tgtaaatatc aagcggtccg tgaccgtacg aacggccaaa atcccagctt tgcgcctcga 3618301 taccggagcc ccagcatatg cttccgacga tttcggtcac gccgccatat ccattaaaaa 3618361 aacgctgatc aagcgctttt aacagaccgt tattcgcata atcatggctg tgcaaaacag 3618421 cagtcgtctc cgacgtttcc ttgatttccc gaagtttatc ggcaatttca tcaagtgcct 3618481 gctcccaaga aatccgcaca aactcgccat tttgtttttt cattggatag cgaagccgat 3618541 caggcgaatt tgtttttgtc tcaagcattc tgccgcggcc gcagatttta ccttccgtaa 3618601 tcggatggtt tggatctccg tccacttttg ttacctttcc atcatcaaca gtcaccaaaa 3618661 agccgcagct gtcccaacaa ttcagcggac atgccgactg atgcactttg ctcatcgccg 3618721 tcttctcctt accttctata tgaaaaagca tgagtgtcgg cctatttatg aagtaggctc 3618781 ctcatgcttg actagtactt tttttagttt tctttcaaat tctcttctcg gaatcataac 3618841 actgtgagag catccctcac acttaattcg aatatccatt cccatgcgta taattttcca 3618901 gctgttcgct ccgcatggat gcggtttttt catttctacg atatcattca ggccaaagtc 3618961 tttatccgcc aagacccttc acctcttttc ctaaactgct gtatctattg tacaaaaaaa 3619021 ctgatcataa gagcaatcaa gatacccgaa aagaaataca tcctcttatt tccatttact 3619081 caaaatagga tataagagca gacaaactaa caaatacaaa ttgagcatcc catatatcgg 3619141 atacaagaac gcgatcaaat cagaaaatcc gaaagaagta aaaggtacca ttaacactaa 3619201 caaaatcaac acaatcatcc atctcggcat atgaataaac gccatcagcc ggctggacaa 3619261 acccagcaaa ccagctaccg tcgtcgtgta aatcgccagg cacagcaccg ccgtcataca 3619321 taaaaaaagg aaataaggcg caccctccag aacggcaaac agcggtattt caaactgaga 3619381 aagggagccc gccagctcca ccaacgtttc attataaaca aatgagatca cgccaaaaat 3619441 aagaccgctt gccacacttg cgatttttgc ttctccgagc cctttcatct ctttcccaac 3619501 agaggataaa atcgcaacaa ctgaaaggat gtttaaagag gtaaacgtaa tgctcgcagg 3619561 ccagttatac tgctgggaca aatcaatcgt ccacgtatgg tgatgtgtgc tctgaaagga 3619621 gatcagcgca tataaaagcc ccgctactaa cacaggaatc aaaatactat ttatagataa 3619681 tattcctttc acatcccaca aaaacaagca cactgtcacg atgcaaatca gcgtgattcc 3619741 ccaccagaaa ggaagcttgt acatttgcag ggtcacaccg cctccggcaa tcatcaccat 3619801 agtcgtcgaa aacaaataaa aaatgatgag gacatcataa attttcgcca gccatggccc 3619861 cattaaatgc tccagaaccg gcagaaaatg agtggattga accttaaaac tgattttcat 3619921 cacaatataa gacgagaaaa tgaacataat tgtaaacagc acaatagcaa gtccgctttc 3619981 cgccccaaaa aactgccata tctcctgacc gctcgcatat ccggccccga tcaggctccc 3620041 taatatgagc agcatccact tcattccggc tctccacaac actatcacct catagacaaa 3620101 gttcagcttg ttcccgttat tgttactata taaataaagg aaagcaaaca tgccatattt 3620161 tcatagacat ttgaacacaa gctgaaatta tcatacgaaa tacacataaa aaagactgct 3620221 aatacggcag tctaaaaaga gatatttatt tgtttgtccg cggaatgaag aagtgaactt 3620281 cactcttcac ttttttctaa ccattcctac ctattcaagt gtttcataag cagaccattg 3620341 cttgatcatg atcgaggcaa tgggggacaa tacttgtaat cgcccactaa ccattcatat 3620401 catgccctct acttttttaa aatctctggt gccatacaca aagcataaaa aatcatactg 3620461 ctggatatac tgtaaacaac cttacataac tacacacacc atagcaattc tgttacctac 3620521 tataacaagg aagtgaaacc catgaatcga aaaggcgggc ttttttcttc tcaggaacga 3620581 gtaaagcaat atgtttcaca tacagatgct gcagcggcaa aacaaatcca aaccatcctt 3620641 tcttcatcct tacgtaaagc tgctggcaaa ccaattgtcg tggtttgtat cggaacagac 3620701 cgttcaaccg gtgactcatt aggcccgctc gtaggaatga aactcaaaca gatgcagctc 3620761 accagattcc atgtctacgg aaccttatct gaccccgtcc atgctgtgaa catgaaggat 3620821 aaaatcaatg acattcataa attacataaa aacccatttg ttatagcagt cgatgcatgc 3620881 ttaggccgcg ttaagagtgt gggttcattt caaatcgggg acgggccatt aaagcccgga 3620941 gccggtgtac aaaaagacct tcctgaagtg ggagatcttc atattaacgg aatcgtgaat 3621001 gtgagcggtt ttatggaata ttttgtattg caaaatacta gactcaactt ggtcatgaat 3621061 atggcaaatg ttctagcgga aggtttgagt ttaacagatc ggacagagtg gaggcaagaa 3621121 cgccttaacc cgttgcaaag gctcactggg cgcatataaa ataaaaacca tcttcgtttg 3621181 aaagatggtt ttttcattta tgattctcgt tcagacaaaa gctctaaaat ccggtcaagg 3621241 tcttcattag agaaaaattc aatttcgatt ttgccttttt tcttctgtct tttaatatta 3621301 actgttgttc caaaataatt ttggagatag gattcccgtt cttttagaac cgcatctttc 3621361 acaggttctt ttttctttgt ttcacgtgga acattctgat tcaactgctg aatcagctgc 3621421 tcaagttggc gaacattgag ctgctccgca atcacttttt gtaccagcgg ttcaagctta 3621481 tttttgtttt ttaagccaag aagcgtgcgt ccatgtccca tagaaagcgt gccttcggca 3621541 ataagctgtt gaatattttc tggcagtgtc agcagtctta aatgattcgc aatatgcggt 3621601 ctgcttttcc caagacgttt ggcaagctgc tcttgtgtga gatctaagtg tttcaaaagg 3621661 gagtcatatg cctgagcctc ttcaagcgga gataaatctt cacgctgaag gttttctaat 3621721 aaagcaattt ccctcattaa cgcctctgat aattcacgga caatggccgg aactgtatct 3621781 aaacctgcca gctttgccgc tcgaaaacgc cgttcacccg caacaatatc atagcctttt 3621841 aaagattttc tgacgataag cggctgaaga atgccatgct gcagcacaga ttcttttagt 3621901 tcagctaatg cctcgtcatc aaagtgtttt cttggctgat aaggattagg gcgtaaatcg 3621961 gcaattttaa tttcttcaac tgtctcttca gacaaatcta cctgattaaa taacgcatta 3622021 atcccttttc caaggccttt agccattcgc agccacttcc tttgctaaat ctaaatatac 3622081 ttccgcacct cttgaccgcg gatcgtataa aatgatgggt tttccgtgac tcggtgcctc 3622141 actcagacgg acattacgcg gaataactgt cttatatact ttatccctaa aatacttttt 3622201 aacctcttca atcacttgaa tgccaaggtt tgtccgggca tcaagcattg tcagcaatac 3622261 accttcaatc attaaatcag tattcaaatg cttttgcaca agacgtactg tatttaataa 3622321 ctggctgaga ccctccaagg cataatattc gcactgtaca ggaatcacaa cggaatccga 3622381 ggcagtaagg gcattaatcg tcagcaagcc caatgacggc ggacaatcaa tgataatata 3622441 atcataattt tgctttactg cttcaagcgc tctcttcaat ctcacttctc ttgatattgt 3622501 aggaaccagc tcgatctcag cccctgcaag ctgaatcgtc gcaggaatca catccaagtt 3622561 ctctactgtc gttgctttaa taatatctat tacatctgca tcatctacta aaatatcgta 3622621 cacacactgc tctacatcgg ctttttcaat ccctaatccg cttgtcgcat ttccctgcgg 3622681 atcaatatct accagcagaa cccttttccc tatgtaagcc aaacatgccc caaggttgac 3622741 agacgtcgtt gttttgccga ccccgccttt ttggttcgta attgctatga tttttcccac 3622801 gatgtcacct actttcacat gaacatgtac tatcttgctt ctattctatc aaaaaaagat 3622861 taaagcgttt catttttttc atcattttgt tccgaatcag aagggaaata attgaaaatt 3622921 caagcacgct ttatgctttc tcttataaat tctgcaattt ctatgttttt ttgacttaaa 3622981 aaaggaattt cttaaagaaa aaaagaagaa gtcacagtac agaacgtgga aacaggatgg 3623041 tgagaaaatg gtttatcaaa cgaagagaga tgtacccgtt acgctgatga ttgtgtttct 3623101 catattactg atacaagcag atgccattgt tccttttgtg ctgggaaata tgagagtttc 3623161 cggctggatc atttttattc tgctgactct tttaaatgga ctcatcattt ggagctttat 3623221 tgacctaaaa tatgtattga aggaacacca tctgatcatt aaagccggat tgatcaaaca 3623281 tcaaattcct tatgaaaaca tcgataaagt cgttcaaaaa aagaaactat ggtccggttt 3623341 tcgtctgatc ggctctcgcc atgccatcac aatatattat caggggggat ggggacatgc 3623401 agtaatttca ccgcaaaaat ctgaagaatt tatccacaag ctcaaagaaa agaattctaa 3623461 tataataata ttcactaaaa gtaagtgatt accttttgtt aaaaatataa aaagctctcc 3623521 tgcttttcag gagagcttct attttggtat gcgaatcgtt aattgaatat attcttcaaa 3623581 ttcttcttct tccgtattca attttacacc gctgtcttcc accattgata gtgactggcg 3623641 aatcgtgttc atcgcaattc ttgtatctct gctgaatgct ttgcgtctcg gctttggctt 3623701 tctctggcct tgctccagca ttttcaccac gcggtcttct gtctgcttta catttaaact 3623761 tttctcaata atctctgtga gcagtgtgac ttggagctca ggctgtttca gcggaatcag 3623821 tgctctggca tggcgctcgg tgattttctt ctccataatc gcctcttgga ccggctgagg 3623881 cagctttaat aaccgaagct tattcgcgat tgtagactgc ccttttccta agcgctgtgc 3623941 gagtgcctcc tgtgttaaat catgcagctc aagcagccta gcataagcat gcgcttcctc 3624001 aatagaagac agttcttccc gctgcaagtt ttcgattaac gccacagaag cggtttccgt 3624061 gtcggaaaaa tccttaataa ttgccggaat cttttcccac tcaagcgatt gcaccgctct 3624121 ccagcgtctt tcacctgcaa tgagttcgta ttggccttct tcttctgtat gcctaacaac 3624181 aatcggctga ataatgccgt gtgtatgaat ggtcattgct aactctttga ttttttcatc 3624241 tgagaaaatg gtgcgtggct gaaaacggtt gggaacgata gcatttaccg gtatttccag 3624301 aatctcttct ttgtttgtat catgttcagc aatctccggc tcctgttcct tctcaccaag 3624361 cccgaagaaa cgagagaatg aatgcttcat gtacctacac cacctttaaa aactgccatt 3624421 tttataattc tattttctca tggtttttcc tgctgtacat ccatcaattt tgatgaaaat 3624481 atgatggtat tgtcatatca ggctgtctaa attacccttc aattggcgat ttattaggag 3624541 ttcccggttt tcttggatac ttcttaggtg tattttttat tttgcgtatc accataatat 3624601 tacgatcgct ttcttcaata ggcagcttaa aagaatggat attctcaagt tctcctccaa 3624661 gcgtcgtgat tgcttttttg cctgcattca gttcttcttc agctgatgcg gcttttaaag 3624721 caacaaataa accgtttttc ttcaccagag gcaagcaaag ctcactcaaa acagataatc 3624781 tcgcaactgc gcgcgccgtc acaatatcat agctttcacg cacgtctttc cgttgcccga 3624841 acgtttcagc tctgtcatgg cagaatgttg tattctccaa ttgcaaagct tcagacaact 3624901 tttctaaaaa cgtaatccgt ttgtttagtg aatccacgat tgtgacatgg aggtgcggaa 3624961 agcatatttt tatcggcaga cttggaaaac ccgctcccgc tccaacatca caaatcgtgt 3625021 tcacctgatt gaagtcgaca taaaaagcag ctgtaatgga atcataaaaa tgctttaaat 3625081 acacttcttt tttctctgtt attgaagtca gattgatttt ttcgttccat tcaaccagca 3625141 tgtcgtaata cagctcaaat tgctccagct gacggggaga aagggagatc cctttttccg 3625201 ccaaaccaga agtgaattct tcaatattca tgccgtcatc ctttctactc ggctatcttc 3625261 gcaatgcgtc cctgctctaa atacaccaat agaattgaaa tgtccgccgg gtttacaccg 3625321 gaaatgcggg aagcctgggc aacagacaaa ggccgtacat ttttcagttt ttgacgcgcc 3625381 tcggtcgcaa tccccttaat tgcgtcataa tcaattcggt ctggaatttt tttattttcc 3625441 atcttcttca gtttttccac ttgctgaaga gatttttcaa tatatccttc atatttcact 3625501 tggatttcta cttgttctgc cacgtcttga ggaaccggca cttctggcgg cgccagtttt 3625561 gtgactgttt catagttcat ttcaggacgt ttcatcaagt ctgtgccgcg aactccatct 3625621 ttcaattcgc ttccgccaag agaacggata tattcttgat tttccggaga cggcttgata 3625681 attacagaat gaagacgttt tttctccgcc tcgatcgccg cttttttctt ctcaaaagcc 3625741 gcatagcgct catcagaaat caatccaatg cgatgtccga tttctgtcag acgcaaatca 3625801 gcattgtcat ggcgaagcag caatctgtat tccgcacgtg atgtcaaaag acgatatggc 3625861 tcattggtac cttttgtcac aaggtcatca atcagaacac caatataggc gtcagaacgg 3625921 cttagaatta cttcttcttt tccaagcgct tttcgtcctg cattgattcc cgccataatc 3625981 ccttgtcccg cagcttcttc ataaccggat gttccgttaa tttggcctgc agtataaagg 3626041 tttgtgattt ttttggtttc aagtgtcggc catagctgtg tcggtacgat tgcatcatac 3626101 tcgatcgcat agccggctct catcatttgc acgttttcaa gtccaggaat cgttgcaagc 3626161 attctttgct gtacgtcttc tggaagactt gtagataaac cttggacata gacttcctgt 3626221 gtatttctgc cttccggctc aaggaagatt tggtgacgcg gtttatcatt aaaacggaca 3626281 actttgtctt caatggatgg gcagtatctt gggcccgtac ctttgatcat accggaatac 3626341 atcggtgaac ggtgcaggtt gctgtcaata atctcatgtg tctcagggct tgtatatgtc 3626401 agccagcaag ggagctgatc tgtgatatat tccactgttt catatgagaa agcgcgaggc 3626461 acatcgtcac caggctgaat ttccgttttg ctgtaatcaa tcgtgtcgct tttaacgcga 3626521 ggcggcgtac ctgttttaaa acgaacaagg tcaaaaccga gttcctccaa atgctcagaa 3626581 agcttaatag aaggctgctg gttattcggg ccgcttgagt aagacagatc gccaagaatg 3626641 atacgtcctc ttaaatatgt ccctgtcgtc atgacaactg ctttcgcacg ataatgtgcg 3626701 cctgtttgtg taataacgcc tcggcattcg ccgtcttcaa cgatcagccg ctccacaatt 3626761 ccttgcagca atgttaagtt tggttctttt tcaagcgtat ttttcatttc gtgctgatat 3626821 tggaatttgt ctgcttgcgc acgcaatgca cgaaccgcag gaccttttcc tgtattcagc 3626881 attctcattt gaatatgtgt tttatcgatg tttcttccca tttctccgcc gagcgcgtca 3626941 atttcgcgga cgacaatccc ttttgcgggg ccgccgacag acggattaca tggcataaat 3627001 gcaaccatat ctaggttgat ggtcaagaca agcgttttgg cgccttggcg tgcagatgcg 3627061 agggcagcct caacaccggc atgcccggcg ccaatcacaa tcacatcgta ttggcctgct 3627121 tcatacccca tgattctagt tcctccttta attattttcc taaacagaat tgagaaaaga 3627181 gctgatcaat taagctttcg tggacagaat ctccaatgat ttcccctaaa agctcccagc 3627241 atcttgtaag gtcaatttgc accatgtcga tcgggacatc ctgttcgatg ccgctaagcg 3627301 catcttcaat ggcgcgtttt gcttgctgta aaatagtgat gtgacgtgtg ttgctgacat 3627361 aagtcagatc accgctttca atggcacccg tgtagaacag tgattgaatc gcttcttcca 3627421 gatcattgat gccttcctct tttaaaagag atgtcgtaac aactggacgt ccattggcaa 3627481 gctcacggac acgttcagtg tcaatcttcg gctcaaggtc agtcttattc aaaatcacga 3627541 taacatccat gccctcaacg gcttcaaaaa gcttcacgtc ttcttcagaa agctcttcac 3627601 tataattaag cacaagtaaa atcaggtccg cttcctttag gacctggcga gaacgttcaa 3627661 caccgattcg ctcaacaata tcctctgttt cacgaatacc tgctgtatca accagacgaa 3627721 gcggaacgcc ccttacattc acgtattcct caatcacatc ccgtgtcgtt ccgggaatat 3627781 cggttacaat ggcttttgcc tcatgaacga ggctgttcag aagagatgat tttcctacgt 3627841 ttggccggcc gataatgacg gtagaaagac cttcacgcaa gatttttcct tgctcagaag 3627901 tcctcagcag cgtctcaatt tcctttttca cggcggttgc cttttcgact aaaatctgat 3627961 gcgtcatttc ctctacatca tcatactccg gataatcaat attcacctca acatgggcca 3628021 gtgtttctaa aatctcactg cgcaaacggc gcaccaaagc agaaagacgc ccttccattt 3628081 gattcatagc aacgttcatt gcccggtccg ttttcgctct gattaagtcc ataaccgctt 3628141 ccgcctgtga aagatcgatt cggccgttta aaaacgcacg tttcgtaaat tcaccaggct 3628201 ctgccagtct cgctccctct ctcaatgcaa gctgaagcac ttggttcaca gtcacaattc 3628261 ccccgtgaca gttaatctcg atgacatctt ctcgtgtaaa agttctcggc gcttttaaca 3628321 ctgataccat tacttcctca acgacacgat ccgaaggtct gtctacgata tgaccataat 3628381 gaatcgtatg tgattcgacc gagctgagtg ttttcccctt cggtccctta taaattttat 3628441 ctgcgatttg aatggcttct ggtccgctca accgtacaat cgcaatcgcg ccttctccca 3628501 tcggtgtgga aattgccgca attgtatcca tgttgttcac ctctctttac ttatacttca 3628561 tctatataaa aaaattttta ttatgccaaa actaaaagat aacatagttt ggttcgaagt 3628621 ggaagatttg ttatccacag aaatagaaat tcgtccctta ttactttaac ttatccacat 3628681 gtgaataaca attaatttta tttcctgaac ttccttttta tcaacaggat acacctaaaa 3628741 agaaaaaact taaacggcaa aaccttgata ttactaggaa aagtagattt ttcggataca 3628801 aaaaaaccga aatccaattt ttatcggact tcggttttat gctatctttt atgggaaata 3628861 acgagatgac gattttcgcc ttcacccatt gaatatgttt tgatctggtg gtttgcatat 3628921 ccagaaagag tatcgtgaat aatttttctt tcgctggacg gcatgggctc aagctggatg 3628981 gattttttcg ttttcaaaac ctggtcagca agcttgatgg ccagctggct cagtgtttct 3629041 tttcttttca aacgatagtt ttctgcatcc accgtcacat ttttatattg gcctggataa 3629101 cggttaaggg caagctgtgt caaagtttca agggcgttta aagtttgtcc tcttttccca 3629161 atcaacaatg ctgccttttc acctgttata tgatatctca ctgtcttttt gctttcttga 3629221 acagtcacat cagacttccc ggcaatggct tcggcaatcg tttgaagata taacttcgct 3629281 tgctgaatcg gatcaatctt ttcaaccagc tttacgatcg caggcttttt accgaaaata 3629341 ccgagaaacc ctttgtttcc ctcttcaata acagtaattt ctaccttatc cttcgttaat 3629401 cccaactctt gcaatccgga ctgtactgct tcatcgacat ttcgccctgc agcagtcaca 3629461 ttcctcactt tttctttcct ccggcttttt gcggctcagg atttttttta atatcaggtc 3629521 ctttaatgag gaaagtttgc gcaatcataa acaagttacc aactacccaa taaagagaaa 3629581 gagccgccgg gaagttgatc gcaaatacga taatcataat tggcataatc caaagcatca 3629641 tcgccatttg cggattttgc tgcgcattgc cagccatcat cagtttttgc tgaacaaatg 3629701 tagcgacacc ggcaacgata ggaagaatat agtaaggatc tttttctcct aagtcaaacc 3629761 ataagaagct atgctctgaa atcgcctggg ttctcatgat cgcatgatag aatccaatta 3629821 aaatcggcat ctggatcaaa atcgggaaac atcccgccaa tggattgaca ccatgctttt 3629881 ggaataaagc cattgtttcc tgttgaagct tttgctgcgt tttttgatcc tttgagctgt 3629941 atttttcttt aagcttttgc atttccggct gtaaagcctg catcgctttc gaacttctca 3630001 gctgcttaat catcagcggt aaaattaata aacgaattaa aatggtaact agaataattg 3630061 aaagcccgta gttatctccc gtcaatttcg ctacatacgt aatgagctca gacaatggat 3630121 atactacgta cttgtcccag aaatgcggac tatctgcagt gatcggctct ttcacactcg 3630181 agcatccagc caaaagcatg aatacgccaa ccatacttaa tagcaaccct attctccttt 3630241 tcaacaacat ttcctcctat aattaatctt tacactcttt tattgcaaag catacttgta 3630301 tgtattttag catctttcag ttttaaatgg tgtctttttc tgatcaacca gaaaggaagc 3630361 gcttttaaaa gttgtaagaa agcagtggtg atgcctactt tgacgaagat ttcttatata 3630421 atgaagactt tctgaataga tgctgcagac tttttttcgt ttcctcatat gtcagctggc 3630481 tcgccggttt tctggcaata atgatgtaat ccttttcctt cagtctctct ttctcttcaa 3630541 gaaaggcctg ccgaatcaaa cgtttgatcc gatttcgcat cacagcattg ccaatttttt 3630601 tgctgacgga aagcccgaca cgcagttcat cattttcagg ctgatcaagc gtatataaga 3630661 caaactggcg gtttgcaact gatgtcccat gtttaaacac tttttgaaaa tcttcatttt 3630721 tctttaaacg atttcgcttc ttcaaatgac tcactccgat actggctggc agaaactttt 3630781 aaaatttatt atgaacatga gatgcatctg aaccaggaag catgccccgg ttcattacgc 3630841 atcacatcta tcttttccca taacgtgaaa aaagaccact gacattattc agtggcctaa 3630901 gctgataata cttttctgcc tttgcggcga cggcgtgcta aaactagacg accgtttttt 3630961 gaactcatac ggcttctgaa gccatgaact ttgctgcgtt tacggttatt cggttggaat 3631021 gttcttttca tttatgacac ctccctcgag gaatagctgt taaagacagt cttacttatt 3631081 atatttgcgt tacctattca ttgtcaactt cactagtgct tttatttctt gcaaccataa 3631141 taggatacca taccttttca actttcgaaa ccttattttt tagattcctt aattttacgg 3631201 aaaaaagaca aattcaaaca atttgcccct aaaatcacgc atgtggatat ctttttcggc 3631261 tttttttagt atccacagag gttatcgaca acattttcac attaccaacc cctgtggaca 3631321 aggttttttc aacaggttgt ccgctttgtg gataagattg tgacaaccat tgcaagctct 3631381 cgtttatttt ggtattatat ttgtgtttta actcttgatt actaatccta cctttcctct 3631441 ttatccacaa agtgtggata agttgtggat tgatttcaca cagcttgtgt agaaggttgt 3631501 ccacaagttg tgaaatttgt cgaaaagcta tttatctact atattatatg ttttcaacat 3631561 ttaatgtgta cgaatggtaa gcgccatttg ctcttttttt gtgttctata acagagaaag 3631621 acgccatttt ctaagaaaag gagggacgtg ccggaag //